Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA000812-TA|BGIBMGA000812-PA|IPR001478|PDZ/DHR/GLGF
(657 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
AL353639-4|CAI41238.1| 2042|Homo sapiens multiple PDZ domain pro... 293 2e-78
AL353639-3|CAI41239.1| 2070|Homo sapiens multiple PDZ domain pro... 293 2e-78
AL162386-2|CAH71899.1| 2070|Homo sapiens multiple PDZ domain pro... 293 2e-78
AL162386-1|CAH71900.1| 2042|Homo sapiens multiple PDZ domain pro... 293 2e-78
AL161449-5|CAI40492.1| 2042|Homo sapiens multiple PDZ domain pro... 293 2e-78
AL161449-4|CAI40493.1| 2070|Homo sapiens multiple PDZ domain pro... 293 2e-78
AF093419-1|AAC61870.1| 2042|Homo sapiens multi PDZ domain protei... 293 2e-78
AB210041-1|BAE06123.1| 2045|Homo sapiens MPDZ variant protein pr... 293 2e-78
AL590374-4|CAH70420.1| 1801|Homo sapiens InaD-like (Drosophila) ... 126 3e-28
AL590374-3|CAH70418.1| 1582|Homo sapiens InaD-like (Drosophila) ... 126 3e-28
AL449143-2|CAI15925.1| 1801|Homo sapiens InaD-like (Drosophila) ... 126 3e-28
AL449143-1|CAI15923.1| 1582|Homo sapiens InaD-like (Drosophila) ... 126 3e-28
AL353802-3|CAI22262.1| 1801|Homo sapiens InaD-like (Drosophila) ... 126 3e-28
AL353802-2|CAI22260.1| 1582|Homo sapiens InaD-like (Drosophila) ... 126 3e-28
AL136458-3|CAI21737.1| 1801|Homo sapiens InaD-like (Drosophila) ... 126 3e-28
AL136458-2|CAI21734.1| 1582|Homo sapiens InaD-like (Drosophila) ... 126 3e-28
AJ224748-1|CAA12113.1| 1582|Homo sapiens Inadl protein. 126 3e-28
AJ224747-1|CAA12112.1| 1552|Homo sapiens Inadl protein. 126 3e-28
AJ001306-1|CAA04666.1| 1524|Homo sapiens PDZ domain protein prot... 126 3e-28
AF397170-1|AAM28433.1| 1801|Homo sapiens Pals1-associated tight ... 126 3e-28
AB044807-1|BAB19683.1| 1134|Homo sapiens PDZ domain protein 3' v... 114 1e-24
AK126776-1|BAC86685.1| 749|Homo sapiens protein ( Homo sapiens ... 87 2e-16
AK123038-1|BAC85520.1| 1284|Homo sapiens protein ( Homo sapiens ... 82 5e-15
U13897-1|AAA50599.1| 904|Homo sapiens homolog of Drosophila dis... 80 3e-14
U13896-1|AAA50598.1| 926|Homo sapiens homolog of Drosophila dis... 80 3e-14
AB209536-1|BAD92773.1| 687|Homo sapiens Presynaptic protein SAP... 80 3e-14
U49089-1|AAB61453.1| 817|Homo sapiens neuroendocrine-dlg protein. 79 4e-14
BC093866-1|AAH93866.1| 817|Homo sapiens discs, large homolog 3 ... 79 4e-14
BC093864-1|AAH93864.1| 817|Homo sapiens discs, large homolog 3 ... 79 4e-14
AL139398-3|CAI41021.1| 849|Homo sapiens discs, large homolog 3 ... 79 4e-14
AL139398-2|CAI41022.1| 817|Homo sapiens discs, large homolog 3 ... 79 4e-14
AB209328-1|BAD92565.1| 917|Homo sapiens synapse-associated prot... 79 4e-14
X80289-1|CAA56563.1| 2466|Homo sapiens protein-tyrosine-phosphat... 77 1e-13
X79676-1|CAA56124.1| 1267|Homo sapiens tyrosine phosphatase prot... 77 1e-13
D21211-1|BAA04752.1| 2294|Homo sapiens protein tyrosine phosphat... 77 1e-13
D21210-1|BAA04751.1| 2466|Homo sapiens protein tyrosine phosphat... 77 1e-13
D21209-1|BAA04750.1| 2485|Homo sapiens protein tyrosine phosphat... 77 1e-13
BC039610-1|AAH39610.1| 604|Homo sapiens PTPN13 protein protein. 77 1e-13
AF233323-1|AAF63474.1| 499|Homo sapiens Fas-associated phosphat... 77 1e-13
AB208904-1|BAD92141.1| 2434|Homo sapiens protein tyrosine phosph... 77 1e-13
BC130449-1|AAI30450.1| 1253|Homo sapiens PPP1R9A protein protein. 77 3e-13
AB033048-1|BAA86536.1| 742|Homo sapiens KIAA1222 protein protein. 77 3e-13
AF038563-1|AAC05370.1| 1455|Homo sapiens membrane associated gua... 76 5e-13
U83192-1|AAC52113.1| 767|Homo sapiens post-synaptic density pro... 75 1e-12
AF156495-1|AAD56173.1| 767|Homo sapiens post-synaptic density 9... 75 1e-12
BC071566-1|AAH71566.1| 1340|Homo sapiens PARD3 protein protein. 74 2e-12
AL450337-8|CAI15041.1| 988|Homo sapiens par-3 partitioning defe... 74 2e-12
AL450337-7|CAI15042.1| 1001|Homo sapiens par-3 partitioning defe... 74 2e-12
AL450337-6|CAI15038.1| 1244|Homo sapiens par-3 partitioning defe... 74 2e-12
AL450337-5|CAI15037.1| 1319|Homo sapiens par-3 partitioning defe... 74 2e-12
AL450337-4|CAI15040.1| 1353|Homo sapiens par-3 partitioning defe... 74 2e-12
AL450337-3|CAI15039.1| 1356|Homo sapiens par-3 partitioning defe... 74 2e-12
AL450337-2|CAI15035.1| 1296|Homo sapiens par-3 partitioning defe... 74 2e-12
AL450337-1|CAI15036.1| 1310|Homo sapiens par-3 partitioning defe... 74 2e-12
AL392123-8|CAI17334.1| 1001|Homo sapiens par-3 partitioning defe... 74 2e-12
AL392123-7|CAI17333.1| 988|Homo sapiens par-3 partitioning defe... 74 2e-12
AL392123-6|CAI17330.1| 1296|Homo sapiens par-3 partitioning defe... 74 2e-12
AL392123-5|CAI17329.1| 1310|Homo sapiens par-3 partitioning defe... 74 2e-12
AL392123-4|CAI17328.1| 1244|Homo sapiens par-3 partitioning defe... 74 2e-12
AL392123-3|CAI17327.1| 1319|Homo sapiens par-3 partitioning defe... 74 2e-12
AL392123-2|CAI17332.1| 1353|Homo sapiens par-3 partitioning defe... 74 2e-12
AL392123-1|CAI17331.1| 1356|Homo sapiens par-3 partitioning defe... 74 2e-12
AL390766-8|CAI17310.1| 988|Homo sapiens par-3 partitioning defe... 74 2e-12
AL390766-7|CAI17311.1| 1001|Homo sapiens par-3 partitioning defe... 74 2e-12
AL390766-6|CAI17307.1| 1296|Homo sapiens par-3 partitioning defe... 74 2e-12
AL390766-5|CAI17306.1| 1310|Homo sapiens par-3 partitioning defe... 74 2e-12
AL390766-4|CAI17305.1| 1244|Homo sapiens par-3 partitioning defe... 74 2e-12
AL390766-3|CAI17304.1| 1319|Homo sapiens par-3 partitioning defe... 74 2e-12
AL390766-2|CAI17309.1| 1353|Homo sapiens par-3 partitioning defe... 74 2e-12
AL390766-1|CAI17308.1| 1356|Homo sapiens par-3 partitioning defe... 74 2e-12
AL360233-8|CAH71168.1| 1001|Homo sapiens par-3 partitioning defe... 74 2e-12
AL360233-7|CAH71167.1| 988|Homo sapiens par-3 partitioning defe... 74 2e-12
AL360233-6|CAH71161.1| 1310|Homo sapiens par-3 partitioning defe... 74 2e-12
AL360233-5|CAH71163.1| 1244|Homo sapiens par-3 partitioning defe... 74 2e-12
AL360233-4|CAH71162.1| 1319|Homo sapiens par-3 partitioning defe... 74 2e-12
AL360233-3|CAH71166.1| 1353|Homo sapiens par-3 partitioning defe... 74 2e-12
AL360233-2|CAH71165.1| 1356|Homo sapiens par-3 partitioning defe... 74 2e-12
AL360233-1|CAH71164.1| 1296|Homo sapiens par-3 partitioning defe... 74 2e-12
AL160409-6|CAH73527.1| 1296|Homo sapiens par-3 partitioning defe... 74 2e-12
AL160409-5|CAH73526.1| 1310|Homo sapiens par-3 partitioning defe... 74 2e-12
AL160409-4|CAH73525.1| 1244|Homo sapiens par-3 partitioning defe... 74 2e-12
AL160409-3|CAH73524.1| 1319|Homo sapiens par-3 partitioning defe... 74 2e-12
AL160409-2|CAH73529.1| 1353|Homo sapiens par-3 partitioning defe... 74 2e-12
AL160409-1|CAH73528.1| 1356|Homo sapiens par-3 partitioning defe... 74 2e-12
AL138768-8|CAI16991.1| 988|Homo sapiens par-3 partitioning defe... 74 2e-12
AL138768-7|CAI16992.1| 1001|Homo sapiens par-3 partitioning defe... 74 2e-12
AL138768-6|CAI16985.1| 1310|Homo sapiens par-3 partitioning defe... 74 2e-12
AL138768-5|CAI16987.1| 1244|Homo sapiens par-3 partitioning defe... 74 2e-12
AL138768-4|CAI16986.1| 1319|Homo sapiens par-3 partitioning defe... 74 2e-12
AL138768-3|CAI16989.1| 1353|Homo sapiens par-3 partitioning defe... 74 2e-12
AL138768-2|CAI16988.1| 1356|Homo sapiens par-3 partitioning defe... 74 2e-12
AL138768-1|CAI16990.1| 1296|Homo sapiens par-3 partitioning defe... 74 2e-12
AK027735-1|BAB55330.1| 865|Homo sapiens protein ( Homo sapiens ... 74 2e-12
AF467006-1|AAL76046.1| 1310|Homo sapiens partitioning-defective ... 74 2e-12
AF467005-1|AAL76045.1| 1244|Homo sapiens partitioning-defective ... 74 2e-12
AF467004-1|AAL76044.1| 1319|Homo sapiens partitioning-defective ... 74 2e-12
AF467003-1|AAL76043.1| 1353|Homo sapiens partitioning-defective ... 74 2e-12
AF467002-1|AAL76042.1| 1356|Homo sapiens partitioning-defective ... 74 2e-12
AF454059-1|AAN75699.1| 747|Homo sapiens SE2-5T2 protein protein. 74 2e-12
AF454058-1|AAN75698.1| 943|Homo sapiens SE2-5L16 protein protein. 74 2e-12
AF454057-1|AAN75697.1| 819|Homo sapiens SE2-5LT1 protein protein. 74 2e-12
AF332593-1|AAK69193.1| 1273|Homo sapiens atypical PKC isotype-sp... 74 2e-12
AF332592-1|AAK69192.1| 988|Homo sapiens atypical PKC isotype-sp... 74 2e-12
AF252293-1|AAF71530.1| 1266|Homo sapiens partitioning-defective ... 74 2e-12
AF196186-1|AAK27892.1| 1031|Homo sapiens atypical PKC isotype-sp... 74 2e-12
AF196185-1|AAK27891.1| 1353|Homo sapiens atypical PKC isotype-sp... 74 2e-12
AB073671-1|BAC54037.1| 1244|Homo sapiens PAR3 protein. 74 2e-12
AL353639-1|CAI41236.1| 611|Homo sapiens multiple PDZ domain pro... 73 2e-12
AL161449-1|CAI40490.1| 611|Homo sapiens multiple PDZ domain pro... 73 2e-12
AB002298-1|BAA20760.2| 2847|Homo sapiens KIAA0300 protein. 73 4e-12
AB014605-1|BAA31680.2| 1483|Homo sapiens KIAA0705 protein protein. 71 1e-11
U12128-1|AAB60339.1| 2490|Homo sapiens protein tyrosine phosphat... 70 3e-11
L34583-1|AAC41755.1| 610|Homo sapiens tyrosine phosphatase prot... 70 3e-11
AC105413-1|AAY40972.1| 1305|Homo sapiens unknown protein. 70 3e-11
U32376-1|AAB04949.1| 870|Homo sapiens channel associated protei... 69 5e-11
AB209252-1|BAD92489.1| 555|Homo sapiens chapsyn-110 variant pro... 69 5e-11
AK127150-1|BAC86854.1| 552|Homo sapiens protein ( Homo sapiens ... 68 9e-11
AL139398-4|CAI41023.1| 512|Homo sapiens discs, large homolog 3 ... 68 1e-10
AB033058-1|BAA86546.1| 520|Homo sapiens KIAA1232 protein protein. 68 1e-10
BC040533-1|AAH40533.1| 549|Homo sapiens DLG4 protein protein. 67 2e-10
BC027618-1|AAH27618.1| 207|Homo sapiens lin-7 homolog B (C. ele... 66 4e-10
AY358744-1|AAQ89104.1| 207|Homo sapiens LIN-7B protein. 66 4e-10
AL353639-2|CAI41237.1| 763|Homo sapiens multiple PDZ domain pro... 66 4e-10
AL161449-2|CAI40491.1| 763|Homo sapiens multiple PDZ domain pro... 66 4e-10
AF311862-1|AAG34117.1| 207|Homo sapiens Lin-7b protein. 66 4e-10
AF401656-1|AAK94066.1| 1462|Homo sapiens MAGI-1C beta protein. 66 5e-10
AJ401189-1|CAC37685.1| 817|Homo sapiens neurabin II protein pro... 65 6e-10
AF338650-1|AAK07661.1| 2641|Homo sapiens PDZ domain-containing p... 65 9e-10
BC122561-1|AAI22562.1| 233|Homo sapiens lin-7 homolog A (C. ele... 64 1e-09
BC118609-1|AAI18610.1| 233|Homo sapiens lin-7 homolog A (C. ele... 64 1e-09
BC099921-1|AAH99921.1| 233|Homo sapiens lin-7 homolog A (C. ele... 64 1e-09
AF173081-1|AAD48500.1| 233|Homo sapiens LIN-7 homolog 1 protein. 64 1e-09
AF087693-1|AAC78481.1| 233|Homo sapiens veli 1 protein. 64 1e-09
AF028826-1|AAB84251.1| 202|Homo sapiens Tax interaction protein... 64 1e-09
AK223156-1|BAD96876.1| 197|Homo sapiens lin-7 homolog C variant... 64 2e-09
BC053907-1|AAH53907.1| 197|Homo sapiens lin-7 homolog C (C. ele... 63 3e-09
AK002077-1|BAA92072.1| 197|Homo sapiens protein ( Homo sapiens ... 63 3e-09
U80754-1|AAC04844.1| 677|Homo sapiens membrane associated guany... 63 3e-09
AF401655-1|AAK94065.1| 1160|Homo sapiens MAGI-1A protein. 63 3e-09
AF401654-1|AAK94064.1| 1287|Homo sapiens MAGI-1B alpha beta prot... 63 3e-09
AB010894-1|BAA32002.1| 1256|Homo sapiens BAI1-associated protein... 63 3e-09
CR407680-1|CAG28608.1| 233|Homo sapiens LIN7A protein. 62 5e-09
AK098775-1|BAC05409.1| 517|Homo sapiens protein ( Homo sapiens ... 62 6e-09
AJ001319-1|CAA04680.1| 453|Homo sapiens multi PDZ domain protei... 62 6e-09
BC016162-1|AAH16162.1| 314|Homo sapiens PPP1R9B protein protein. 62 8e-09
BC130409-1|AAI30410.1| 1125|Homo sapiens membrane associated gua... 60 3e-08
AL390759-4|CAH74143.1| 1125|Homo sapiens membrane associated gua... 60 3e-08
AL390759-3|CAH74142.1| 1150|Homo sapiens membrane associated gua... 60 3e-08
AL390759-2|CAH74141.1| 1481|Homo sapiens membrane associated gua... 60 3e-08
AL389921-3|CAH71508.1| 1150|Homo sapiens membrane associated gua... 60 3e-08
AL389921-2|CAH71509.1| 1125|Homo sapiens membrane associated gua... 60 3e-08
AL389921-1|CAH71507.1| 1481|Homo sapiens membrane associated gua... 60 3e-08
AL365225-3|CAH70945.1| 1150|Homo sapiens membrane associated gua... 60 3e-08
AL365225-2|CAH70946.1| 1125|Homo sapiens membrane associated gua... 60 3e-08
AL365225-1|CAH70944.1| 1481|Homo sapiens membrane associated gua... 60 3e-08
AL133517-10|CAI22555.1| 1125|Homo sapiens membrane associated gu... 60 3e-08
AL133517-9|CAI22554.1| 1150|Homo sapiens membrane associated gua... 60 3e-08
AL133517-8|CAI22553.1| 1481|Homo sapiens membrane associated gua... 60 3e-08
AF213259-1|AAG43837.1| 1125|Homo sapiens membrane-associated gua... 60 3e-08
AB046854-1|BAB13460.1| 874|Homo sapiens KIAA1634 protein protein. 60 3e-08
AL590374-2|CAH70416.1| 199|Homo sapiens InaD-like (Drosophila) ... 59 4e-08
AL353802-1|CAI22258.1| 199|Homo sapiens InaD-like (Drosophila) ... 59 4e-08
AL136458-1|CAI21733.1| 199|Homo sapiens InaD-like (Drosophila) ... 59 4e-08
AL392123-9|CAI17335.1| 179|Homo sapiens par-3 partitioning defe... 59 6e-08
AF177228-1|AAG33676.1| 667|Homo sapiens CTCL tumor antigen se2-... 59 6e-08
AF257238-1|AAG24545.1| 1150|Homo sapiens membrane-associated gua... 58 7e-08
U68138-1|AAB07736.1| 321|Homo sapiens PSD-95 protein. 58 1e-07
AF028825-1|AAB84250.1| 296|Homo sapiens Tax interaction protein... 58 1e-07
BC021135-1|AAH21135.1| 346|Homo sapiens INADL protein protein. 58 1e-07
AL353639-5|CAI41240.1| 353|Homo sapiens multiple PDZ domain pro... 56 3e-07
AK057965-1|BAB71623.1| 624|Homo sapiens protein ( Homo sapiens ... 56 5e-07
AF466152-1|AAL79827.1| 1136|Homo sapiens partitioning-defective ... 56 5e-07
AF428250-1|AAL30664.1| 1205|Homo sapiens partitioning-defective ... 56 5e-07
AB092439-1|BAC54285.1| 1205|Homo sapiens PAR3 beta alternatively... 56 5e-07
AB073472-1|BAC54035.1| 1104|Homo sapiens PAR3 beta protein. 56 5e-07
BC115394-1|AAI15395.1| 1076|Homo sapiens glutamate receptor inte... 55 9e-07
BC115393-1|AAI15394.1| 1076|Homo sapiens glutamate receptor inte... 55 9e-07
AJ133439-1|CAB39895.1| 849|Homo sapiens GRIP1 protein protein. 55 9e-07
BC015560-1|AAH15560.1| 320|Homo sapiens DLG1 protein protein. 54 1e-06
AL161449-7|CAI40494.1| 335|Homo sapiens multiple PDZ domain pro... 54 1e-06
AK056157-1|BAB71106.1| 545|Homo sapiens protein ( Homo sapiens ... 54 1e-06
AF428251-1|AAL30665.1| 1143|Homo sapiens partitioning-defective ... 54 1e-06
AC011750-1|AAY14757.1| 346|Homo sapiens unknown protein. 54 1e-06
AC006043-1|AAD15413.2| 333|Homo sapiens unknown protein. 54 1e-06
AB029018-1|BAA83047.1| 1098|Homo sapiens KIAA1095 protein protein. 54 1e-06
AK131530-1|BAD18668.1| 1331|Homo sapiens protein ( Homo sapiens ... 54 2e-06
AK124565-1|BAC85888.1| 1163|Homo sapiens protein ( Homo sapiens ... 54 2e-06
AB051506-1|BAB21810.2| 1050|Homo sapiens KIAA1719 protein protein. 54 2e-06
U02478-1|AAC50059.1| 1612|Homo sapiens AF-6 protein. 54 2e-06
BC040272-1|AAH40272.1| 454|Homo sapiens IL16 protein protein. 54 2e-06
AY324389-1|AAQ86961.1| 1332|Homo sapiens neural interleukin 16 p... 54 2e-06
AL731868-7|CAI40830.1| 1501|Homo sapiens myeloid/lymphoid or mix... 54 2e-06
AL731868-3|CAI40826.1| 1612|Homo sapiens myeloid/lymphoid or mix... 54 2e-06
AL731868-2|CAI40825.1| 1665|Homo sapiens myeloid/lymphoid or mix... 54 2e-06
AL731868-1|CAI40824.1| 1824|Homo sapiens myeloid/lymphoid or mix... 54 2e-06
AL161973-1|CAB82312.1| 1410|Homo sapiens hypothetical protein pr... 54 2e-06
AL049698-5|CAI42816.1| 1501|Homo sapiens myeloid/lymphoid or mix... 54 2e-06
AL049698-3|CAI42814.1| 1612|Homo sapiens myeloid/lymphoid or mix... 54 2e-06
AL049698-2|CAI42813.1| 1665|Homo sapiens myeloid/lymphoid or mix... 54 2e-06
AL049698-1|CAI42812.1| 1824|Homo sapiens myeloid/lymphoid or mix... 54 2e-06
AL009178-3|CAI20902.1| 1612|Homo sapiens myeloid/lymphoid or mix... 54 2e-06
AL009178-2|CAI20901.1| 1665|Homo sapiens myeloid/lymphoid or mix... 54 2e-06
AL009178-1|CAI20900.1| 1824|Homo sapiens myeloid/lymphoid or mix... 54 2e-06
AB209420-1|BAD92657.1| 1639|Homo sapiens Afadin variant protein. 54 2e-06
D63481-1|BAA09768.3| 1630|Homo sapiens KIAA0147 protein protein. 53 3e-06
BC044627-1|AAH44627.1| 682|Homo sapiens SCRIB protein protein. 53 3e-06
BC014632-1|AAH14632.2| 832|Homo sapiens SCRIB protein protein. 53 3e-06
AY062238-1|AAL38976.1| 1630|Homo sapiens scribble protein. 53 3e-06
AF271734-1|AAP88018.1| 1601|Homo sapiens SCRIB1 variant N1 protein. 53 3e-06
AF240677-1|AAP88017.1| 1630|Homo sapiens CRIB1 protein. 53 3e-06
AK024507-1|BAB15797.1| 331|Homo sapiens FLJ00117 protein protein. 53 4e-06
BC126311-1|AAI26312.1| 1075|Homo sapiens hypothetical protein FL... 52 5e-06
BC117317-1|AAI17318.1| 1075|Homo sapiens hypothetical protein FL... 52 5e-06
BC029054-1|AAH29054.1| 511|Homo sapiens PDZK7 protein protein. 52 5e-06
BC004919-1|AAH04919.2| 371|Homo sapiens FLJ10324 protein protein. 52 5e-06
AL133215-20|CAI10934.1| 517|Homo sapiens novel protein protein. 52 5e-06
AK026862-1|BAB15577.1| 517|Homo sapiens protein ( Homo sapiens ... 52 5e-06
AK001186-1|BAA91543.1| 654|Homo sapiens protein ( Homo sapiens ... 52 5e-06
AK000997-1|BAA91459.1| 580|Homo sapiens protein ( Homo sapiens ... 52 5e-06
AC092610-2|AAS07560.1| 383|Homo sapiens unknown protein. 52 5e-06
AC092610-1|AAS07559.1| 654|Homo sapiens unknown protein. 52 5e-06
AB058752-1|BAB47478.1| 1114|Homo sapiens KIAA1849 protein protein. 52 5e-06
U82108-1|AAB53042.1| 326|Homo sapiens SIP-1 protein. 52 6e-06
BC106001-1|AAI06002.1| 337|Homo sapiens SLC9A3R2 protein protein. 52 6e-06
BC069014-1|AAH69014.1| 372|Homo sapiens SLC9A3R2 protein protein. 52 6e-06
BC014513-1|AAH14513.2| 374|Homo sapiens SLC9A3R2 protein protein. 52 6e-06
AF035771-1|AAC52090.1| 337|Homo sapiens Na+/H+ exchanger regula... 52 6e-06
AF004900-1|AAC63061.1| 337|Homo sapiens E3KARP protein. 52 6e-06
AC005600-1|AAC34208.1| 337|Homo sapiens Na+/H+ exchanger regula... 52 6e-06
AC004808-1|AAC23438.1| 434|Homo sapiens unknown protein. 52 6e-06
AB016243-1|BAA33216.1| 337|Homo sapiens regulatory factor 2 of ... 52 6e-06
U82972-1|AAB58261.1| 631|Homo sapiens interleukin-16 protein. 52 9e-06
S81601-1|AAB36371.2| 374|Homo sapiens prIL-16 protein. 52 9e-06
M90391-1|AAD04636.1| 631|Homo sapiens putative IL-16 protein pr... 52 9e-06
BX005072-4|CAI23643.1| 261|Homo sapiens PDZ domain containing 5... 52 9e-06
BC110798-1|AAI10799.1| 320|Homo sapiens FRMPD2 related 1 protein. 52 9e-06
BC073954-1|AAH73954.1| 320|Homo sapiens FERM and PDZ domain con... 52 9e-06
BC072395-1|AAH72395.1| 320|Homo sapiens FRMPD2 related 1 protein. 52 9e-06
BC071635-1|AAH71635.1| 320|Homo sapiens FRMPD2 related 2 protein. 52 9e-06
BC063590-1|AAH63590.1| 649|Homo sapiens SCRIB protein protein. 52 9e-06
BC050362-1|AAH50362.1| 576|Homo sapiens Unknown (protein for IM... 52 9e-06
BC031614-1|AAH31614.1| 261|Homo sapiens FERM and PDZ domain con... 52 9e-06
AY497901-1|AAR89904.1| 631|Homo sapiens interleukin 16 (lymphoc... 52 9e-06
AY491519-1|AAS79660.1| 261|Homo sapiens PDZ domain-containing p... 52 9e-06
AL450334-6|CAI15688.1| 223|Homo sapiens PDZ domain containing 5... 52 9e-06
AL450334-5|CAI15687.1| 261|Homo sapiens PDZ domain containing 5... 52 9e-06
AK222512-1|BAD96232.1| 677|Homo sapiens Hypothetical protein FL... 52 9e-06
AK126222-1|BAC86494.1| 824|Homo sapiens protein ( Homo sapiens ... 52 9e-06
AF077011-1|AAD15990.1| 631|Homo sapiens interleukin 16 protein. 52 9e-06
BC007704-1|AAH07704.1| 145|Homo sapiens synaptojanin 2 binding ... 51 1e-05
AY534623-1|AAT01566.1| 145|Homo sapiens activin receptor intera... 51 1e-05
AJ003029-1|CAB92969.1| 539|Homo sapiens syntrophin 5 protein. 51 1e-05
U40572-1|AAC50449.1| 540|Homo sapiens beta2-syntrophin protein. 51 1e-05
U31466-1|AAB49040.1| 1433|Homo sapiens nitric oxide synthase pro... 51 1e-05
U17327-1|AAA62405.1| 1434|Homo sapiens neuronal nitric oxide syn... 51 1e-05
U17326-1|AAB60654.1| 1554|Homo sapiens neuronal nitric oxide syn... 51 1e-05
L02881-1|AAA36376.1| 1433|Homo sapiens nitric oxide synthase pro... 51 1e-05
D16408-1|BAA03895.1| 1434|Homo sapiens nitric oxide synthase pro... 51 1e-05
BC048215-1|AAH48215.1| 540|Homo sapiens syntrophin, beta 2 (dys... 51 1e-05
AY445095-1|AAR07069.1| 1434|Homo sapiens nitric oxide synthase 1... 51 1e-05
AF243385-1|AAK15149.1| 267|Homo sapiens beta-2 syntrophin protein. 51 1e-05
AK025340-1|BAB15115.1| 275|Homo sapiens protein ( Homo sapiens ... 50 2e-05
Z50150-1|CAA90511.1| 450|Homo sapiens tyrosine kinase activator... 50 3e-05
AL138895-4|CAI17247.1| 345|Homo sapiens deafness, autosomal rec... 50 3e-05
AL138895-3|CAI17246.1| 907|Homo sapiens deafness, autosomal rec... 50 3e-05
AB040959-1|BAA96050.1| 963|Homo sapiens KIAA1526 protein protein. 50 3e-05
AB011399-3|BAA32485.1| 1611|Homo sapiens AF-6 protein. 50 3e-05
AB011399-2|BAA32484.1| 1816|Homo sapiens AF-6 protein. 50 3e-05
AB011399-1|BAA32483.1| 1743|Homo sapiens AF-6 protein. 50 3e-05
BC132785-1|AAI32786.1| 630|Homo sapiens MPP4 protein protein. 50 3e-05
BC108907-1|AAI08908.2| 917|Homo sapiens TJP3 protein protein. 50 3e-05
BC108906-1|AAI08907.1| 938|Homo sapiens TJP3 protein protein. 50 3e-05
AK002133-1|BAA92098.1| 145|Homo sapiens protein ( Homo sapiens ... 50 3e-05
AF316032-1|AAK71862.1| 637|Homo sapiens membrane protein palmit... 50 3e-05
AC007279-2|AAY15057.1| 637|Homo sapiens unknown protein. 50 3e-05
AC005954-1|AAC72274.1| 952|Homo sapiens ZO-3 [Homo sapiens] pro... 50 3e-05
AB053302-1|BAB69012.1| 593|Homo sapiens ALS2CR5 protein. 50 3e-05
AB014460-3|BAA32696.1| 199|Homo sapiens solute carrier family 9... 50 3e-05
U75651-1|AAB84228.1| 716|Homo sapiens dishevelled 3 protein. 49 6e-05
D86963-1|BAA13199.2| 725|Homo sapiens KIAA0208 protein. 49 6e-05
BC034737-1|AAH34737.1| 632|Homo sapiens ligand of numb-protein ... 49 6e-05
BC032459-1|AAH32459.1| 716|Homo sapiens dishevelled, dsh homolo... 49 6e-05
BC022983-1|AAH22983.1| 728|Homo sapiens LNX1 protein protein. 49 6e-05
BC018289-1|AAH18289.1| 608|Homo sapiens Unknown (protein for IM... 49 6e-05
AY358326-1|AAQ88692.1| 632|Homo sapiens LNX protein. 49 6e-05
AL110278-1|CAB53713.1| 548|Homo sapiens hypothetical protein pr... 49 6e-05
AK056823-1|BAB71291.1| 728|Homo sapiens protein ( Homo sapiens ... 49 6e-05
AF237782-1|AAK15039.1| 632|Homo sapiens multi-PDZ-domain-contai... 49 6e-05
AF006013-1|AAB65244.1| 716|Homo sapiens dishevelled 3 protein. 49 6e-05
BT009822-1|AAP88824.1| 736|Homo sapiens dishevelled, dsh homolo... 48 8e-05
BC114943-1|AAI14944.1| 342|Homo sapiens MAGIX protein protein. 48 8e-05
BC014844-1|AAH14844.1| 736|Homo sapiens dishevelled, dsh homolo... 48 8e-05
AK056190-1|BAB71117.1| 345|Homo sapiens protein ( Homo sapiens ... 48 8e-05
AF006012-1|AAB65243.1| 736|Homo sapiens dishevelled 2 protein. 48 8e-05
U49262-1|AAB47447.1| 716|Homo sapiens dishevelled protein. 48 1e-04
BC036755-1|AAH36755.1| 690|Homo sapiens ligand of numb-protein ... 47 2e-04
AL138699-1|CAH73446.1| 690|Homo sapiens ligand of numb-protein ... 47 2e-04
Z85999-4|CAI43172.1| 454|Homo sapiens golgi associated PDZ and ... 46 3e-04
Z85999-3|CAI43173.1| 462|Homo sapiens golgi associated PDZ and ... 46 3e-04
L31529-1|AAA81523.1| 538|Homo sapiens beta1-syntrophin protein. 46 3e-04
L04953-1|AAA61307.1| 708|Homo sapiens x11 protein protein. 46 3e-04
BC101824-1|AAI01825.1| 528|Homo sapiens sorting nexin family me... 46 3e-04
BC101822-1|AAI01823.1| 528|Homo sapiens sorting nexin family me... 46 3e-04
BC101000-1|AAI01001.1| 528|Homo sapiens sorting nexin family me... 46 3e-04
BC100999-1|AAI01000.1| 528|Homo sapiens sorting nexin family me... 46 3e-04
BC100998-1|AAI00999.1| 528|Homo sapiens sorting nexin family me... 46 3e-04
BC098573-1|AAH98573.1| 538|Homo sapiens syntrophin, beta 1 (dys... 46 3e-04
BC009553-1|AAH09553.1| 454|Homo sapiens golgi associated PDZ an... 46 3e-04
AY033606-1|AAK57733.1| 454|Homo sapiens fused in glioblastoma p... 46 3e-04
AL589939-2|CAH70199.1| 462|Homo sapiens golgi associated PDZ an... 46 3e-04
AL589939-1|CAH70198.1| 454|Homo sapiens golgi associated PDZ an... 46 3e-04
AL589765-2|CAI17165.1| 541|Homo sapiens sorting nexin family me... 46 3e-04
AL589765-1|CAI17164.1| 528|Homo sapiens sorting nexin family me... 46 3e-04
AL391335-2|CAH73502.1| 541|Homo sapiens sorting nexin family me... 46 3e-04
AL391335-1|CAH73501.1| 528|Homo sapiens sorting nexin family me... 46 3e-04
AL355140-1|CAI15443.1| 837|Homo sapiens amyloid beta (A4) precu... 46 3e-04
AL353693-1|CAH74104.1| 837|Homo sapiens amyloid beta (A4) precu... 46 3e-04
AF450008-1|AAL47160.1| 454|Homo sapiens CFTR-associated ligand ... 46 3e-04
AF287894-1|AAG00572.1| 462|Homo sapiens PIST protein. 46 3e-04
AF047347-1|AAC39766.1| 837|Homo sapiens adaptor protein X11alph... 46 3e-04
AF029106-1|AAC05304.1| 837|Homo sapiens Mint1 protein. 46 3e-04
AF028828-1|AAB84253.1| 288|Homo sapiens Tax interaction protein... 46 3e-04
AB007957-1|BAE16986.1| 523|Homo sapiens KIAA0488 protein. 46 3e-04
BC017225-1|AAH17225.1| 531|Homo sapiens DVL1 protein protein. 46 4e-04
AL139287-16|CAI23185.1| 670|Homo sapiens dishevelled, dsh homol... 46 4e-04
AL139287-15|CAI23187.1| 695|Homo sapiens dishevelled, dsh homol... 46 4e-04
AK128686-1|BAC87571.1| 137|Homo sapiens protein ( Homo sapiens ... 46 4e-04
AF006011-1|AAB65242.1| 670|Homo sapiens dishevelled 1 protein. 46 4e-04
AB043635-1|BAA96236.2| 277|Homo sapiens 16-5-5 protein. 46 6e-04
U40571-1|AAC50448.1| 505|Homo sapiens alpha1-syntrophin protein. 45 7e-04
S81737-1|AAB36398.1| 505|Homo sapiens alpha 1 syntrophin protein. 45 7e-04
BC053350-1|AAH53350.1| 358|Homo sapiens solute carrier family 9... 45 7e-04
BC049220-1|AAH49220.1| 428|Homo sapiens SLC9A3R1 protein protein. 45 7e-04
BC026215-1|AAH26215.1| 505|Homo sapiens syntrophin, alpha 1 (dy... 45 7e-04
BC011777-1|AAH11777.1| 358|Homo sapiens solute carrier family 9... 45 7e-04
BC003361-1|AAH03361.1| 358|Homo sapiens solute carrier family 9... 45 7e-04
BC001443-1|AAH01443.1| 358|Homo sapiens solute carrier family 9... 45 7e-04
AL355392-7|CAC15884.1| 505|Homo sapiens syntrophin, alpha 1 (dy... 45 7e-04
AF036241-1|AAC04572.1| 358|Homo sapiens Na+/H+ exchange regulat... 45 7e-04
AF015926-1|AAC52084.1| 358|Homo sapiens ezrin-radixin-moesin bi... 45 7e-04
BC038105-1|AAH38105.1| 576|Homo sapiens MPP7 protein protein. 45 0.001
AL391423-2|CAI17345.1| 576|Homo sapiens novel protein protein. 45 0.001
AL390866-2|CAI12708.1| 576|Homo sapiens novel protein protein. 45 0.001
AL355501-2|CAI13641.1| 576|Homo sapiens novel protein protein. 45 0.001
AK074145-1|BAB84971.1| 174|Homo sapiens FLJ00218 protein protein. 45 0.001
BC128989-1|AAI28990.1| 821|Homo sapiens LRRC7 protein protein. 44 0.001
BC104829-1|AAI04830.1| 517|Homo sapiens syntrophin, gamma 1 pro... 44 0.001
BC093746-1|AAH93746.2| 778|Homo sapiens PDZ domain containing R... 44 0.001
BC093744-1|AAH93744.1| 778|Homo sapiens PDZ domain containing R... 44 0.001
BC075072-1|AAH75072.1| 517|Homo sapiens syntrophin, gamma 1 pro... 44 0.001
BC060797-1|AAH60797.1| 376|Homo sapiens PARD6G protein protein. 44 0.001
AL391728-2|CAH73692.1| 1495|Homo sapiens leucine rich repeat con... 44 0.001
AL391728-1|CAH73691.1| 1537|Homo sapiens leucine rich repeat con... 44 0.001
AL359412-2|CAH74019.1| 1495|Homo sapiens leucine rich repeat con... 44 0.001
AL359412-1|CAH74018.1| 1537|Homo sapiens leucine rich repeat con... 44 0.001
AL158840-2|CAH70975.1| 1495|Homo sapiens leucine rich repeat con... 44 0.001
AL158840-1|CAH70974.1| 1537|Homo sapiens leucine rich repeat con... 44 0.001
AL157948-2|CAI22426.1| 1495|Homo sapiens leucine rich repeat con... 44 0.001
AL157948-1|CAI22425.1| 1537|Homo sapiens leucine rich repeat con... 44 0.001
AL117353-1|CAI23423.1| 1495|Homo sapiens leucine rich repeat con... 44 0.001
AK074573-1|BAC11068.1| 320|Homo sapiens protein ( Homo sapiens ... 44 0.001
AJ003030-1|CAB92968.1| 480|Homo sapiens syntrophin 4 protein. 44 0.001
AF434715-1|AAL28133.1| 1537|Homo sapiens densin-180 protein. 44 0.001
AB044556-1|BAB40757.1| 376|Homo sapiens PAR-6 gamma protein. 44 0.001
AB037786-1|BAA92603.1| 831|Homo sapiens KIAA1365 protein protein. 44 0.001
AB011131-1|BAA25485.1| 1212|Homo sapiens KIAA0559 protein protein. 44 0.001
U46461-1|AAC50682.1| 670|Homo sapiens cytoplasmic phosphoprotei... 44 0.002
AK131554-1|BAD18688.1| 776|Homo sapiens protein ( Homo sapiens ... 44 0.002
U48252-1|AAC72246.1| 457|Homo sapiens protein kinase C-binding ... 44 0.002
BC060847-1|AAH60847.1| 372|Homo sapiens PARD6B protein protein. 44 0.002
AL031680-1|CAB44747.3| 372|Homo sapiens par-6 partitioning defe... 44 0.002
AK131208-1|BAD18399.1| 602|Homo sapiens protein ( Homo sapiens ... 44 0.002
AF053412-1|AAC12732.1| 130|Homo sapiens interleukin-16 protein. 44 0.002
AB053303-1|BAB69013.1| 266|Homo sapiens ALS2CR5 protein. 44 0.002
AB044555-1|BAB40756.1| 372|Homo sapiens PAR-6 beta protein. 44 0.002
L27476-1|AAA61300.1| 1116|Homo sapiens X104 protein. 43 0.003
BC126464-1|AAI26465.1| 1371|Homo sapiens erbb2 interacting prote... 43 0.003
BC117277-1|AAI17278.1| 775|Homo sapiens PDZD4 protein protein. 43 0.003
BC115015-1|AAI15016.1| 1367|Homo sapiens ERBB2IP protein protein. 43 0.003
BC027592-1|AAH27592.1| 1190|Homo sapiens tight junction protein ... 43 0.003
BC015626-1|AAH15626.1| 345|Homo sapiens par-6 partitioning defe... 43 0.003
AL358113-5|CAH70870.1| 161|Homo sapiens tight junction protein ... 43 0.003
AL358113-3|CAH70868.1| 1190|Homo sapiens tight junction protein ... 43 0.003
AL358113-2|CAM13389.1| 1043|Homo sapiens tight junction protein ... 43 0.003
AL358113-1|CAH70867.1| 993|Homo sapiens tight junction protein ... 43 0.003
AK091444-1|BAC03666.1| 765|Homo sapiens protein ( Homo sapiens ... 43 0.003
AJ277095-1|CAB85490.1| 346|Homo sapiens PAR-6 protein protein. 43 0.003
AF489824-1|AAM28524.1| 993|Homo sapiens tight junction protein ... 43 0.003
AF276423-1|AAK69431.1| 1412|Homo sapiens densin-180-like protein... 43 0.003
AF265565-1|AAF75548.1| 345|Homo sapiens PAR6 protein. 43 0.003
AF263744-1|AAF77048.1| 1371|Homo sapiens erbb2-interacting prote... 43 0.003
AF252292-1|AAF71529.1| 345|Homo sapiens PAR6C protein. 43 0.003
AF177533-4|AAD56219.2| 1020|Homo sapiens tight junction protein ... 43 0.003
AF177533-3|AAC02527.2| 1167|Homo sapiens tight junction protein ... 43 0.003
AF177533-2|AAD56218.2| 1043|Homo sapiens tight junction protein ... 43 0.003
AF177533-1|AAD20387.2| 1190|Homo sapiens tight junction protein ... 43 0.003
AF083892-1|AAC33121.1| 166|Homo sapiens tight junction protein ... 43 0.003
AF028827-1|AAB84252.1| 231|Homo sapiens Tax interaction protein... 43 0.003
AB103478-1|BAD16631.1| 769|Homo sapiens PDZ domain containing 4... 43 0.003
AB043634-1|BAA96235.1| 346|Homo sapiens PAR-6 protein. 43 0.003
AB041642-1|BAB16105.1| 345|Homo sapiens PAR-6 protein. 43 0.003
AB040877-1|BAA95968.1| 416|Homo sapiens KIAA1444 protein protein. 43 0.003
AB033051-1|BAA86539.2| 1371|Homo sapiens KIAA1225 protein protein. 43 0.003
AK026417-1|BAB15479.1| 409|Homo sapiens protein ( Homo sapiens ... 43 0.004
U37707-1|AAB36964.1| 585|Homo sapiens dlg3 protein. 42 0.005
BC056865-1|AAH56865.1| 585|Homo sapiens MPP3 protein protein. 42 0.005
BC047017-1|AAH47017.1| 370|Homo sapiens MPP3 protein protein. 42 0.005
BC016057-1|AAH16057.1| 533|Homo sapiens USH1C protein protein. 42 0.005
BC006518-1|AAH06518.1| 519|Homo sapiens PDZ domain containing 1... 42 0.005
BC006496-1|AAH06496.1| 519|Homo sapiens PDZ domain containing 1... 42 0.005
AM050145-1|CAJ18315.1| 315|Homo sapiens membrane protein palmit... 42 0.005
AM050144-1|CAJ18313.1| 585|Homo sapiens membrane protein palmit... 42 0.005
AL390725-5|CAI13716.1| 519|Homo sapiens PDZ domain containing 1... 42 0.005
AL390725-4|CAI13715.1| 264|Homo sapiens PDZ domain containing 1... 42 0.005
AF039700-1|AAC18049.1| 652|Homo sapiens antigen NY-CO-38 protein. 42 0.005
AF039699-1|AAC18048.1| 403|Homo sapiens antigen NY-CO-37 protein. 42 0.005
AB018687-1|BAA81740.1| 552|Homo sapiens autoimmune enteropathy-... 42 0.005
AB006955-1|BAA81739.1| 521|Homo sapiens AIE-75 protein. 42 0.005
BC115012-1|AAI15013.1| 1371|Homo sapiens erbb2 interacting prote... 42 0.007
BC025743-1|AAH25743.1| 330|Homo sapiens MPP3 protein protein. 42 0.007
AK024422-1|BAB15712.1| 394|Homo sapiens FLJ00011 protein protein. 42 0.007
CR456550-1|CAG30436.1| 415|Homo sapiens PRKCABP protein. 42 0.009
BC125116-1|AAI25117.1| 531|Homo sapiens STXBP4 protein protein. 42 0.009
BC117695-1|AAI17696.1| 574|Homo sapiens DLG5 protein protein. 42 0.009
BC017561-1|AAH17561.1| 415|Homo sapiens protein interacting wit... 42 0.009
AY705392-1|AAU10527.1| 921|Homo sapiens calcium/calmodulin-depe... 42 0.009
AY190519-1|AAO38848.1| 1692|Homo sapiens Rab3A-interacting molec... 42 0.009
AL627402-4|CAH71237.1| 909|Homo sapiens calcium/calmodulin-depe... 42 0.009
AL627402-3|CAH71240.1| 926|Homo sapiens calcium/calmodulin-depe... 42 0.009
AL627402-2|CAH71239.1| 921|Homo sapiens calcium/calmodulin-depe... 42 0.009
AL603754-5|CAI41635.1| 926|Homo sapiens calcium/calmodulin-depe... 42 0.009
AL603754-4|CAI41636.1| 921|Homo sapiens calcium/calmodulin-depe... 42 0.009
AL603754-2|CAI41634.1| 909|Homo sapiens calcium/calmodulin-depe... 42 0.009
AL590011-1|CAI16961.1| 1039|Homo sapiens regulating synaptic mem... 42 0.009
AL450306-3|CAI17324.2| 1919|Homo sapiens discs, large homolog 5 ... 42 0.009
AL450306-2|CAI17323.1| 880|Homo sapiens discs, large homolog 5 ... 42 0.009
AL445256-1|CAI39598.1| 1039|Homo sapiens regulating synaptic mem... 42 0.009
AL445239-6|CAI41093.1| 926|Homo sapiens calcium/calmodulin-depe... 42 0.009
AL445239-5|CAI41094.1| 921|Homo sapiens calcium/calmodulin-depe... 42 0.009
AL445239-3|CAI41092.1| 909|Homo sapiens calcium/calmodulin-depe... 42 0.009
AL391421-2|CAI12104.2| 1919|Homo sapiens discs, large homolog 5 ... 42 0.009
AL391421-1|CAI12103.1| 880|Homo sapiens discs, large homolog 5 ... 42 0.009
AL390056-1|CAI21554.1| 1039|Homo sapiens regulating synaptic mem... 42 0.009
AL353691-6|CAI42245.1| 926|Homo sapiens calcium/calmodulin-depe... 42 0.009
AL353691-5|CAI42246.1| 921|Homo sapiens calcium/calmodulin-depe... 42 0.009
AL353691-3|CAI42244.1| 909|Homo sapiens calcium/calmodulin-depe... 42 0.009
AL161449-8|CAI40495.1| 228|Homo sapiens multiple PDZ domain pro... 42 0.009
AL158144-4|CAI42763.1| 926|Homo sapiens calcium/calmodulin-depe... 42 0.009
AL158144-3|CAI42764.1| 921|Homo sapiens calcium/calmodulin-depe... 42 0.009
AL158144-1|CAI42762.1| 909|Homo sapiens calcium/calmodulin-depe... 42 0.009
AL049654-1|CAB41082.1| 415|Homo sapiens hypothetical protein pr... 42 0.009
AL034373-1|CAI20558.1| 1039|Homo sapiens regulating synaptic mem... 42 0.009
AL031587-6|CAB37478.1| 415|Homo sapiens protein ( Human DNA seq... 42 0.009
AK122865-1|BAC85511.1| 553|Homo sapiens ma isoform. protein. 42 0.009
AF352034-1|AAL83938.1| 1809|Homo sapiens DLG5 protein. 42 0.009
AF352033-1|AAL83937.1| 1809|Homo sapiens DLG5 protein. 42 0.009
AF262404-1|AAF72666.1| 754|Homo sapiens calcium/calmodulin-depe... 42 0.009
AF231710-1|AAF97502.1| 415|Homo sapiens PICK1 protein protein. 42 0.009
AF083893-1|AAC33122.1| 96|Homo sapiens tight junction protein ... 42 0.009
AF032119-1|AAB88125.1| 921|Homo sapiens hCASK protein. 42 0.009
AB208859-1|BAD92096.1| 917|Homo sapiens calcium/calmodulin-depe... 42 0.009
AB091676-1|BAC65420.1| 1764|Homo sapiens discs large protein lp-... 42 0.009
AB051866-1|BAB87242.1| 1470|Homo sapiens RIM long form protein. 42 0.009
AB045726-1|BAB87121.1| 1028|Homo sapiens RIM short form protein. 42 0.009
AB026491-1|BAA89294.1| 415|Homo sapiens PICK1 protein. 42 0.009
AB011155-1|BAA25509.2| 1952|Homo sapiens KIAA0583 protein protein. 42 0.009
AB002338-1|BAA20798.1| 1053|Homo sapiens KIAA0340 protein. 42 0.009
BC108289-1|AAI08290.1| 423|Homo sapiens PCLO protein protein. 41 0.012
AL358113-4|CAH70869.1| 101|Homo sapiens tight junction protein ... 41 0.012
U61843-1|AAC61295.1| 674|Homo sapiens discs large protein P-dlg... 41 0.016
BC073996-1|AAH73996.1| 845|Homo sapiens DLG5 protein protein. 41 0.016
AK027292-1|BAB55020.1| 548|Homo sapiens protein ( Homo sapiens ... 41 0.016
U79255-1|AAB50203.1| 218|Homo sapiens X11 protein protein. 40 0.021
BC117311-1|AAI17312.1| 898|Homo sapiens CASK protein protein. 40 0.021
BC082986-1|AAH82986.1| 737|Homo sapiens APBA2 protein protein. 40 0.021
AL627402-6|CAH71241.1| 590|Homo sapiens calcium/calmodulin-depe... 40 0.021
AL627402-5|CAH71238.1| 897|Homo sapiens calcium/calmodulin-depe... 40 0.021
AL603754-6|CAI41638.1| 590|Homo sapiens calcium/calmodulin-depe... 40 0.021
AL603754-3|CAI41637.1| 897|Homo sapiens calcium/calmodulin-depe... 40 0.021
AL603754-1|CAI41633.1| 518|Homo sapiens calcium/calmodulin-depe... 40 0.021
AL445239-7|CAI41096.1| 590|Homo sapiens calcium/calmodulin-depe... 40 0.021
AL445239-4|CAI41095.1| 897|Homo sapiens calcium/calmodulin-depe... 40 0.021
AL445239-1|CAI41090.1| 518|Homo sapiens calcium/calmodulin-depe... 40 0.021
AL353691-7|CAI42248.1| 590|Homo sapiens calcium/calmodulin-depe... 40 0.021
AL353691-4|CAI42247.1| 897|Homo sapiens calcium/calmodulin-depe... 40 0.021
AL158144-5|CAI42766.1| 590|Homo sapiens calcium/calmodulin-depe... 40 0.021
AL158144-2|CAI42765.1| 897|Homo sapiens calcium/calmodulin-depe... 40 0.021
AK222640-1|BAD96360.1| 415|Homo sapiens protein kinase C, alpha... 40 0.021
AF262405-1|AAF72667.1| 871|Homo sapiens calcium/calmodulin-depe... 40 0.021
AF035582-1|AAB88198.1| 897|Homo sapiens CASK protein. 40 0.021
AF029108-1|AAC05306.1| 218|Homo sapiens Mint2 protein. 40 0.021
AB209281-1|BAD92518.1| 752|Homo sapiens amyloid beta A4 precurs... 40 0.021
AB039327-1|BAB12252.2| 518|Homo sapiens calcium/calmodulin-depe... 40 0.021
AB014719-1|BAA34734.1| 749|Homo sapiens XllL protein. 40 0.021
BC057394-1|AAH57394.1| 1562|Homo sapiens Rho guanine nucleotide ... 40 0.028
AY830839-1|AAW52510.1| 2434|Homo sapiens serine/threonine protei... 40 0.028
AL356104-3|CAH72940.1| 1522|Homo sapiens Rho guanine nucleotide ... 40 0.028
AL356104-2|CAH72939.1| 1562|Homo sapiens Rho guanine nucleotide ... 40 0.028
AL157713-2|CAH70127.1| 1522|Homo sapiens Rho guanine nucleotide ... 40 0.028
AL157713-1|CAH70128.1| 1562|Homo sapiens Rho guanine nucleotide ... 40 0.028
>AL353639-4|CAI41238.1| 2042|Homo sapiens multiple PDZ domain
protein protein.
Length = 2042
Score = 293 bits (718), Expect = 2e-78
Identities = 201/479 (41%), Positives = 275/479 (57%), Gaps = 58/479 (12%)
Query: 178 SVSPTITITVPVELP-----EIEIIHVDLNKNVYGLGITVAGYVCEKE-ELSGIFVKSII 231
S SPT T + V+ E E V+L KNV GLGIT+AGY+ +K+ E SGIFVKSI
Sbjct: 352 SSSPTSTPELRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSIT 411
Query: 232 EGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHL 291
+ S+ E G+I+I D+II VDG +L +N Q+VE+LR+TG +V L L R RG K E
Sbjct: 412 KSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMR--RGMKQEA- 468
Query: 292 QLAIFNEERXXXXXXXXXXLSWFPVPSQLENSITEIEPEPESNTTIDSSVLEVGDLQEPT 351
E LS PV + + E + E ++T ++++L PT
Sbjct: 469 ------ELMSREDVTKDADLS--PVNASIIKENYE-KDEDFLSSTRNTNIL-------PT 512
Query: 352 QEE----LDQRFDEILAVDKED--IVKKWKEEIGSDKEILVAEIKKLE---GLGISLEGT 402
+EE L +EI K++ ++ KW+ +G + EI+VA + K GLGISLE T
Sbjct: 513 EEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEAT 572
Query: 403 VDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP 462
V HH+IRSVLP+GPVG G L +GDELLEVN L G H +VVNILK+LP
Sbjct: 573 VG---------HHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELP 623
Query: 463 DRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTSSTA 522
V +VC R ++ P D S L ++ K D S+
Sbjct: 624 IEVTMVCCRRTVP----PTTQSELD----------SLDLCDIELTEKPHVDLGEFIGSSE 669
Query: 523 TLTNHSEQSKKSRSLECVSG-LAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIV 581
T + +S E V LAMW++ + L K +GLGFSILDYQDP+DP TVI+
Sbjct: 670 TEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPASTVII 729
Query: 582 VRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPLP 640
+RSLVPGG+AEK+G + PGDR+M VN V+++N++L++AV+ALKGAP GTV++G+A+PLP
Sbjct: 730 IRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLP 788
Score = 114 bits (275), Expect = 8e-25
Identities = 49/86 (56%), Positives = 68/86 (79%)
Query: 7 WAQVEVVELTNDGNGLGFNLVGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLR 66
W +E +EL NDG+GLGF ++GG++TGV++K +LPGGVAD+ RL SGDH+L++G +L
Sbjct: 252 WQHMETIELVNDGSGLGFGIIGGKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLA 311
Query: 67 GFTSEQVAAVLRQAGPVVRLLVARPA 92
G +SEQVA VLRQ G V+L++AR A
Sbjct: 312 GMSSEQVAQVLRQCGNRVKLMIARGA 337
Score = 111 bits (267), Expect = 8e-24
Identities = 118/438 (26%), Positives = 197/438 (44%), Gaps = 55/438 (12%)
Query: 220 EELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
E + GIF+K ++E S A ++G +K DRI+EVDG+ L D S+ Q+VE +R G V ++
Sbjct: 1180 EVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMV 1239
Query: 280 ERYLRGPKFEHLQLAIFNEERXXXXXXXXXXLSWFPVPSQLENSITEIEPEPESNTTI-- 337
+ + P+ L + N + + S +E EPE ++
Sbjct: 1240 QSIINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADKAPSQSESEPEKAPLCSVPP 1299
Query: 338 --DSSVLEVGDLQEPTQEELDQRFDEILAVDKED-IVKKWK---EEIGS-DKEILVAEIK 390
S+ E+G + TQ + + VDKED WK E G+ E+ + E++
Sbjct: 1300 PPPSAFAEMG--SDHTQSSASKISQD---VDKEDEFGYSWKNIRERYGTLTGELHMIELE 1354
Query: 391 K-LEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K GLG+SL G D R +I + P+G G G L DELLE+N L+G
Sbjct: 1355 KGHSGLGLSLAGNKD-----RSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGR 1409
Query: 450 THSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVK 509
+H +I+K P +V+++ RN + VN + G + S S N L
Sbjct: 1410 SHQNASSIIKCAPSKVKIIFIRN------KDAVNQMAVCPGNAVEPLPSNSEN----LQN 1459
Query: 510 AQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDY 569
+++ ++ TS A K + LE L K GLG +I +
Sbjct: 1460 KETEPTVTTSDAAV---DLSSFKNVQHLE----------------LPKDQGGLGIAISE- 1499
Query: 570 QDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRG 629
+D + + ++++SL GVA +G + GD++++V+ + +++ + LK A +
Sbjct: 1500 EDTL----SGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTA-KM 1554
Query: 630 TVKVGIARPLPPQDSSKS 647
TVK+ I P + S
Sbjct: 1555 TVKLTIHAENPDSQAVPS 1572
Score = 68.9 bits (161), Expect = 5e-11
Identities = 72/272 (26%), Positives = 115/272 (42%), Gaps = 26/272 (9%)
Query: 13 VELTNDGNGLGFNLVGG------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLR 66
VELT + GLG + G +G+ +K + + D R+Q GD ++ V NL+
Sbjct: 378 VELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQ 437
Query: 67 GFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVPTKILADPELLDRHLIET 126
GFT++Q VLR G V L + R A + TK AD ++ +I+
Sbjct: 438 GFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDV----TKD-ADLSPVNASIIKE 492
Query: 127 GYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQKIPDHPIVCDSVSPTITIT 186
Y D + NI E +++A + I D QK + + I
Sbjct: 493 NYEKDEDFLSSTRNTNIL-PTEEEGYPLLSAEIEEIED-AQK--QEAALLTKWQRIMGIN 548
Query: 187 VPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKIND 246
EI + HV GLGI++ V F++S++ SGK+ D
Sbjct: 549 Y-----EIVVAHVSKFSENSGLGISLEATVGHH------FIRSVLPEGPVGHSGKLFSGD 597
Query: 247 RIIEVDGISLADKSNPQSVEILRNTGISVHLV 278
++EV+GI+L +++ V IL+ I V +V
Sbjct: 598 ELLEVNGITLLGENHQDVVNILKELPIEVTMV 629
Score = 66.9 bits (156), Expect = 2e-10
Identities = 74/285 (25%), Positives = 125/285 (43%), Gaps = 20/285 (7%)
Query: 13 VELTNDGNGLGFNLVGGRST---GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFT 69
+E++ GLG ++VGG T ++I V G A KD RL +GD +L+V ++LR T
Sbjct: 1630 IEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKAT 1689
Query: 70 SEQVAAVLRQAGPVVRLLVARP---------ADPATALRAPQPGTALVPTKI--LADPEL 118
++ VLRQ VRL + R D T +PG L + + D +
Sbjct: 1690 HDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGKRNDTGV 1749
Query: 119 LDRHLIETGYG-AVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQKIPDHPIVC- 176
+++ G A L Q +NG++ T AA+ + I
Sbjct: 1750 FVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKCSLGTVTLEVGRIKAG 1809
Query: 177 DSVSPTITITVPVEL--PEIEIIH-VDLNKN-VYGLGITVAGYVCEKEELSGIFVKSIIE 232
S S ++ + EI+ + V++ K LGI++AG V IF+ +
Sbjct: 1810 SSTSESLESSSKKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHP 1869
Query: 233 GSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHL 277
A Q+ K+++ DRI+ + G S ++ Q+V +L+N S+ +
Sbjct: 1870 TGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEM 1914
Score = 59.3 bits (137), Expect = 4e-08
Identities = 67/285 (23%), Positives = 120/285 (42%), Gaps = 29/285 (10%)
Query: 379 GSDKEILVAEI-KKLEGLGISLEGTVDVEGGQELRPHH-YIRSVLPDGPVGLQGVLNAGD 436
G + E E+ K ++GLGI++ G + G ++L P +++S+ V G + GD
Sbjct: 370 GEESETFDVELTKNVQGLGITIAGYI---GDKKLEPSGIFVKSITKSSAVEHDGRIQIGD 426
Query: 437 ELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGP----RPVVNLASDREGFE 492
+++ V+ L G T+ + V +L+ V L R + R V +D
Sbjct: 427 QIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVN 486
Query: 493 ARKIISGSLNNLTTLVKAQSDTSI---NTSSTATLTNHSEQSKKSRSLECVSGLAMWQ-- 547
A II + + + +T+I L+ E+ + ++ E L WQ
Sbjct: 487 A-SIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAAL-LTKWQRI 544
Query: 548 ---SKEDIVMLVKA---DQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGD 601
+ E +V V + GLG S+ + V + +RS++P G +G++ GD
Sbjct: 545 MGINYEIVVAHVSKFSENSGLGISL---EATVGHH----FIRSVLPEGPVGHSGKLFSGD 597
Query: 602 RVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPLPPQDSSK 646
++ VNG+++ V LK P V R +PP S+
Sbjct: 598 ELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSE 642
Score = 59.3 bits (137), Expect = 4e-08
Identities = 58/206 (28%), Positives = 95/206 (46%), Gaps = 23/206 (11%)
Query: 8 AQVEVVELTNDGNGLGFNL------VGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVG 61
A ++ +EL GLGF++ + ST ++I+ ++PGG+A+KD RL GD ++ V
Sbjct: 696 AGIQHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVN 755
Query: 62 SVNLRGFTSEQVAAVLRQA-GPVVRLLVAR--PADPATALRAPQPGTALVPTKI-----L 113
VNL + E+ L+ A VR+ VA+ P P + + + L P L
Sbjct: 756 DVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSPEEGYVSAKEDSFLYPPHSCEEAGL 815
Query: 114 ADPELL--DRHLIETGYGAVYDLSQCYSDYN-INGQNGETETSIVAAAVSVIGDN---PQ 167
AD L D L+ T + D S S Y+ N T+ SI++ S GD
Sbjct: 816 ADKPLFRADLALVGTNDADLVDESTFESPYSPENDSIYSTQASILSLHGSSCGDGLNYGS 875
Query: 168 KIPDHP---IVCDSVSPTITITVPVE 190
+P P ++ +S P + + + +E
Sbjct: 876 SLPSSPPKDVIENSCDPVLDLHMSLE 901
Score = 57.2 bits (132), Expect = 2e-07
Identities = 63/278 (22%), Positives = 119/278 (42%), Gaps = 26/278 (9%)
Query: 377 EIGSDKEILVAEIKKLEG-LGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAG 435
++ S K + E+ K +G LGI++ + G I+S+ G G L G
Sbjct: 1474 DLSSFKNVQHLELPKDQGGLGIAISEEDTLSGV-------IIKSLTEHGVAATDGRLKVG 1526
Query: 436 DELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARK 495
D++L V++ + G + +++LK V+L + DS P A+ E
Sbjct: 1527 DQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGE------ 1580
Query: 496 IISGSLNNLTTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVML 555
N+ +L+ QS + ++ N S S + + + E + +
Sbjct: 1581 ----KKNSSQSLMVPQS----GSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEI 1632
Query: 556 VKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNAT 615
K GLG SI+ D + I++ + G A K+G + GD+++ VNG+ ++ AT
Sbjct: 1633 SKGRTGLGLSIVGGSDTLLG---AIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKAT 1689
Query: 616 LDQAVQALKGAPRGTVKVGIARPLPPQDSSKSKGTINV 653
D+A+ L+ P+ V++ + R P + T+ +
Sbjct: 1690 HDEAINVLRQTPQ-RVRLTLYRDEAPYKEEEVCDTLTI 1726
Score = 54.0 bits (124), Expect = 2e-06
Identities = 32/91 (35%), Positives = 51/91 (56%), Gaps = 6/91 (6%)
Query: 557 KADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATL 616
K +GLG SI+ + N T + V +V GG+A+ +G + GD+++ VNG ++NAT
Sbjct: 1731 KPGKGLGLSIVGKR-----NDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNAT- 1784
Query: 617 DQAVQALKGAPRGTVKVGIARPLPPQDSSKS 647
+AV AL GTV + + R +S+S
Sbjct: 1785 QEAVAALLKCSLGTVTLEVGRIKAGSSTSES 1815
Score = 52.4 bits (120), Expect = 5e-06
Identities = 28/85 (32%), Positives = 46/85 (54%), Gaps = 5/85 (5%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDHVLQVGSV 63
Q + + L +GLGF++VGG + + +K V G A +D RL+ GD ++ V
Sbjct: 1956 QCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQ 2015
Query: 64 NLRGFTSEQVAAVLRQAGPVVRLLV 88
+L G T E+ A+L++ V L+V
Sbjct: 2016 SLEGVTHEEAVAILKRTKGTVTLMV 2040
Score = 52.0 bits (119), Expect = 6e-06
Identities = 43/170 (25%), Positives = 82/170 (48%), Gaps = 17/170 (10%)
Query: 463 DRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTSSTA 522
DR+ +C ++ VNL + G ++++G +++ + Q + + ++ S
Sbjct: 1883 DRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGG--DVSVVTGHQQEPASSSLSFT 1940
Query: 523 TLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTV-IV 581
LT+ S +C S + L + GLGFSI+ P+G + I
Sbjct: 1941 GLTSSSIFQDDLGPPQCKS-----------ITLERGPDGLGFSIVGGYG--SPHGDLPIY 1987
Query: 582 VRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTV 631
V+++ G A ++G + GD++++VNG S++ T ++AV LK +GTV
Sbjct: 1988 VKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILK-RTKGTV 2036
Score = 50.4 bits (115), Expect = 2e-05
Identities = 28/76 (36%), Positives = 45/76 (59%), Gaps = 1/76 (1%)
Query: 207 GLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADK-SNPQSV 265
GLG +V G E GIFV+ I EGS A + G++K D+I+ ++G +L ++ Q++
Sbjct: 147 GLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAI 206
Query: 266 EILRNTGISVHLVLER 281
IL+ +V LV+ R
Sbjct: 207 SILQKAKDTVQLVIAR 222
Score = 50.4 bits (115), Expect = 2e-05
Identities = 39/122 (31%), Positives = 61/122 (50%), Gaps = 12/122 (9%)
Query: 163 GDNPQKIPDHPIVCDSVSPTITITV---PVELPEIEIIHVDLNKNVYGLGITVAGYVCEK 219
G PQ + PIV S S TI+ PV +E I +L + GLG + G
Sbjct: 223 GSLPQLVS--PIVSRSPSAASTISAHSNPVHWQHMETI--ELVNDGSGLGFGIIG----- 273
Query: 220 EELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
+ +G+ VK+I+ G A+Q G++ D I+++ LA S+ Q ++LR G V L++
Sbjct: 274 GKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMI 333
Query: 280 ER 281
R
Sbjct: 334 AR 335
Score = 50.4 bits (115), Expect = 2e-05
Identities = 31/110 (28%), Positives = 53/110 (48%), Gaps = 8/110 (7%)
Query: 528 SEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVP 587
S + ++ S WQ E I LV GLGF I + T ++V++++P
Sbjct: 234 SRSPSAASTISAHSNPVHWQHMETIE-LVNDGSGLGFGI------IGGKATGVIVKTILP 286
Query: 588 GGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIAR 637
GGVA+++G + GD ++ + + + +Q Q L+ VK+ IAR
Sbjct: 287 GGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQC-GNRVKLMIAR 335
Score = 50.4 bits (115), Expect = 2e-05
Identities = 27/94 (28%), Positives = 52/94 (55%), Gaps = 1/94 (1%)
Query: 177 DSVSPTITITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSG-IFVKSIIEGSS 235
D+ T + P+ + E I H++L K GLG ++ Y + S I ++S++ G
Sbjct: 679 DAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGI 738
Query: 236 AEQSGKIKINDRIIEVDGISLADKSNPQSVEILR 269
AE+ G++ DR++ V+ ++L + S ++VE L+
Sbjct: 739 AEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALK 772
Score = 50.0 bits (114), Expect = 3e-05
Identities = 67/297 (22%), Positives = 129/297 (43%), Gaps = 29/297 (9%)
Query: 5 TEWAQVEVVELTND-GNGLGFNLVGGRSTG-----------VVIKYVLPGGVADKDRRLQ 52
+ W Q VEL + LG ++VGGR G + IK+VL A K+ L+
Sbjct: 1144 SNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLK 1203
Query: 53 SGDHVLQVGSVNLRGFTSEQVAAVLRQAG-PV---VRLLVARP--ADPATALRAPQPGTA 106
GD +++V ++LR + EQ +R+AG PV V+ ++ RP + + L P
Sbjct: 1204 PGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYN 1263
Query: 107 LVPTKILADPELLDRHLIETGYGAVYDLSQ-CYSDYNINGQNGETETSIVAAAVSVIGDN 165
T AD ++ + + + + C E + ++ S I +
Sbjct: 1264 FSSTNPFADSLQINADKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQD 1323
Query: 166 PQKIPDHPIVCDSVSPTI-TITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSG 224
K + ++ T+T + + E+E H L G+++AG ++ +S
Sbjct: 1324 VDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGL-------GLSLAGNK-DRSRMS- 1374
Query: 225 IFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
+F+ I +A + G+++I D ++E++G L +S+ + I++ V ++ R
Sbjct: 1375 VFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIR 1431
Score = 50.0 bits (114), Expect = 3e-05
Identities = 28/104 (26%), Positives = 54/104 (51%), Gaps = 4/104 (3%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTGVVIKYVL---PGGVADKDRRLQSGDHVLQVGSVNL 65
++ ++EL +GLG +L G + + +++ P G A KD RLQ D +L++ L
Sbjct: 1347 ELHMIELEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQIL 1406
Query: 66 RGFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVP 109
G + + +++++ A V+++ R D + A PG A+ P
Sbjct: 1407 YGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQM-AVCPGNAVEP 1449
Score = 50.0 bits (114), Expect = 3e-05
Identities = 29/101 (28%), Positives = 57/101 (56%), Gaps = 6/101 (5%)
Query: 181 PTITIT-VPVELPEIEII-HVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQ 238
PT+T + V+L + + H++L K+ GLGI ++ E++ LSG+ +KS+ E A
Sbjct: 1464 PTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAIS----EEDTLSGVIIKSLTEHGVAAT 1519
Query: 239 SGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
G++K+ D+I+ VD + + + +L+ ++V L +
Sbjct: 1520 DGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTI 1560
Score = 48.8 bits (111), Expect = 6e-05
Identities = 36/125 (28%), Positives = 58/125 (46%), Gaps = 5/125 (4%)
Query: 503 NLTTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDI-VMLVKADQG 561
N L+ A+ T+ TA S + L + + E V L K QG
Sbjct: 327 NRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQKGEESETFDVELTKNVQG 386
Query: 562 LGFSILDY--QDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQA 619
LG +I Y ++P+G I V+S+ E +G I GD++++V+G ++Q T QA
Sbjct: 387 LGITIAGYIGDKKLEPSG--IFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQA 444
Query: 620 VQALK 624
V+ L+
Sbjct: 445 VEVLR 449
Score = 47.6 bits (108), Expect = 1e-04
Identities = 30/106 (28%), Positives = 54/106 (50%), Gaps = 4/106 (3%)
Query: 178 SVSPTITITVPVELPEIEIIH--VDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSS 235
S +P I + P P I ++++K GLG+++ G L I + + E +
Sbjct: 1607 SSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGG--SDTLLGAIIIHEVYEEGA 1664
Query: 236 AEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
A + G++ D+I+EV+GI L ++ +++ +LR T V L L R
Sbjct: 1665 ACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYR 1710
Score = 47.2 bits (107), Expect = 2e-04
Identities = 20/64 (31%), Positives = 39/64 (60%)
Query: 417 IRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDS 476
++++LP G G L +GD +L++ + L G++ +V +L+Q +RV+L+ AR +I+
Sbjct: 281 VKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARGAIEE 340
Query: 477 GPRP 480
P
Sbjct: 341 RTAP 344
Score = 46.4 bits (105), Expect = 3e-04
Identities = 35/138 (25%), Positives = 69/138 (50%), Gaps = 3/138 (2%)
Query: 143 INGQNGETETSIVAAA-VSVIGDNPQKIPDHPIVCDSVSPTITITVPVELPEIEIIHVDL 201
+ +G E +VA VSV+ + Q+ + ++ + + P+ + I ++
Sbjct: 1905 LKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKSITLER 1964
Query: 202 NKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSN 261
+ G I V GY +L I+VK++ +A + G++K D+II V+G SL ++
Sbjct: 1965 GPDGLGFSI-VGGYGSPHGDLP-IYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTH 2022
Query: 262 PQSVEILRNTGISVHLVL 279
++V IL+ T +V L++
Sbjct: 2023 EEAVAILKRTKGTVTLMV 2040
Score = 46.0 bits (104), Expect = 4e-04
Identities = 31/107 (28%), Positives = 58/107 (54%), Gaps = 5/107 (4%)
Query: 538 ECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTV-IVVRSLVPGGVAEKNGE 596
+ + +A + E +L GLGFS++ + + G + I V+ + G VA ++G
Sbjct: 124 QLIKNMAQGRHVEVFELLKPPSGGLGFSVVGLRS--ENRGELGIFVQEIQEGSVAHRDGR 181
Query: 597 ISPGDRVMSVNGVSI-QNATLDQAVQALKGAPRGTVKVGIARPLPPQ 642
+ D+++++NG ++ Q T QA+ L+ A + TV++ IAR PQ
Sbjct: 182 LKETDQILAINGQALDQTITHQQAISILQKA-KDTVQLVIARGSLPQ 227
Score = 44.0 bits (99), Expect = 0.002
Identities = 27/85 (31%), Positives = 46/85 (54%), Gaps = 1/85 (1%)
Query: 5 TEWAQVEVVELTNDGNGLGFNLVGGRS-TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSV 63
+ + V+ +EL D GLG + + +GV+IK + GVA D RL+ GD +L V
Sbjct: 1476 SSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDE 1535
Query: 64 NLRGFTSEQVAAVLRQAGPVVRLLV 88
+ G+ E+ ++L+ A V+L +
Sbjct: 1536 IVVGYPIEKFISLLKTAKMTVKLTI 1560
Score = 43.6 bits (98), Expect = 0.002
Identities = 27/76 (35%), Positives = 38/76 (50%), Gaps = 3/76 (3%)
Query: 393 EGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHS 452
+GLG S+ G G P Y+++V G G L GD+++ VN L G+TH
Sbjct: 1967 DGLGFSIVGGYGSPHGD--LPI-YVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHE 2023
Query: 453 EVVNILKQLPDRVRLV 468
E V ILK+ V L+
Sbjct: 2024 EAVAILKRTKGTVTLM 2039
Score = 42.3 bits (95), Expect = 0.005
Identities = 29/97 (29%), Positives = 50/97 (51%), Gaps = 6/97 (6%)
Query: 529 EQSKKSRSLECVS-GLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVP 587
EQS + + ECV +S E + + K + LG ++ +D G ++VRS++
Sbjct: 984 EQSSLACNAECVMLQNVSKESFERTINIAKGNSSLGMTVSANKD-----GLGMIVRSIIH 1038
Query: 588 GGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
GG ++G I+ GD ++S+N S + T QA L+
Sbjct: 1039 GGAISRDGRIAIGDCILSINEESTISVTNAQARAMLR 1075
Score = 37.9 bits (84), Expect = 0.11
Identities = 27/91 (29%), Positives = 45/91 (49%), Gaps = 4/91 (4%)
Query: 394 GLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRL-HGLTHS 452
GLG S+ G G EL +++ + G L D++L +N L +TH
Sbjct: 147 GLGFSVVGLRSENRG-ELGI--FVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQ 203
Query: 453 EVVNILKQLPDRVRLVCARNSIDSGPRPVVN 483
+ ++IL++ D V+LV AR S+ P+V+
Sbjct: 204 QAISILQKAKDTVQLVIARGSLPQLVSPIVS 234
Score = 37.5 bits (83), Expect = 0.15
Identities = 31/137 (22%), Positives = 58/137 (42%), Gaps = 4/137 (2%)
Query: 199 VDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLAD 258
+++ K LG+TV+ K+ L G+ V+SII G + + G+I I D I+ ++ S
Sbjct: 1009 INIAKGNSSLGMTVSA---NKDGL-GMIVRSIIHGGAISRDGRIAIGDCILSINEESTIS 1064
Query: 259 KSNPQSVEILRNTGISVHLVLERYLRGPKFEHLQLAIFNEERXXXXXXXXXXLSWFPVPS 318
+N Q+ +LR + + Y+ E ++++ + + +P
Sbjct: 1065 VTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDIPE 1124
Query: 319 QLENSITEIEPEPESNT 335
E E E NT
Sbjct: 1125 LPEREEGEGEESELQNT 1141
Score = 36.7 bits (81), Expect = 0.26
Identities = 21/62 (33%), Positives = 36/62 (58%), Gaps = 2/62 (3%)
Query: 575 PNGTV-IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKV 633
P G V I + + P GVA + ++ GDR++++ G S + T QAV LK A G++++
Sbjct: 1856 PLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNA-SGSIEM 1914
Query: 634 GI 635
+
Sbjct: 1915 QV 1916
Score = 35.9 bits (79), Expect = 0.45
Identities = 23/80 (28%), Positives = 35/80 (43%), Gaps = 3/80 (3%)
Query: 17 NDGNGLGFNLVGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAV 76
N G G+ G I+ VLP G +L SGD +L+V + L G + V +
Sbjct: 562 NSGLGISLEATVGHH---FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNI 618
Query: 77 LRQAGPVVRLLVARPADPAT 96
L++ V ++ R P T
Sbjct: 619 LKELPIEVTMVCCRRTVPPT 638
Score = 35.9 bits (79), Expect = 0.45
Identities = 21/79 (26%), Positives = 42/79 (53%), Gaps = 4/79 (5%)
Query: 207 GLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVE 266
GLG+++ G K +G+FV I++G A+ G++ D+I+ V+G + + +
Sbjct: 1735 GLGLSIVG----KRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAA 1790
Query: 267 ILRNTGISVHLVLERYLRG 285
+L+ + +V L + R G
Sbjct: 1791 LLKCSLGTVTLEVGRIKAG 1809
Score = 33.9 bits (74), Expect = 1.8
Identities = 23/97 (23%), Positives = 45/97 (46%), Gaps = 6/97 (6%)
Query: 3 LSTEWAQVEVVELTNDG-NGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDH 56
L++E + VE+ + LG ++ GG + + I + P GVA + ++L+ GD
Sbjct: 1825 LASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDR 1884
Query: 57 VLQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVARPAD 93
++ + + G T Q +L+ A + + V D
Sbjct: 1885 IVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGD 1921
Score = 32.7 bits (71), Expect = 4.2
Identities = 23/82 (28%), Positives = 37/82 (45%), Gaps = 5/82 (6%)
Query: 388 EIKK--LEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYR 445
E+KK + LGIS+ G V G +I + P G L GD ++ +
Sbjct: 1836 EMKKGPTDSLGISIAGGVGSPLGDV---PIFIAMMHPTGVAAQTQKLRVGDRIVTICGTS 1892
Query: 446 LHGLTHSEVVNILKQLPDRVRL 467
G+TH++ VN+LK + +
Sbjct: 1893 TEGMTHTQAVNLLKNASGSIEM 1914
>AL353639-3|CAI41239.1| 2070|Homo sapiens multiple PDZ domain
protein protein.
Length = 2070
Score = 293 bits (718), Expect = 2e-78
Identities = 201/479 (41%), Positives = 275/479 (57%), Gaps = 58/479 (12%)
Query: 178 SVSPTITITVPVELP-----EIEIIHVDLNKNVYGLGITVAGYVCEKE-ELSGIFVKSII 231
S SPT T + V+ E E V+L KNV GLGIT+AGY+ +K+ E SGIFVKSI
Sbjct: 352 SSSPTSTPELRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSIT 411
Query: 232 EGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHL 291
+ S+ E G+I+I D+II VDG +L +N Q+VE+LR+TG +V L L R RG K E
Sbjct: 412 KSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMR--RGMKQEA- 468
Query: 292 QLAIFNEERXXXXXXXXXXLSWFPVPSQLENSITEIEPEPESNTTIDSSVLEVGDLQEPT 351
E LS PV + + E + E ++T ++++L PT
Sbjct: 469 ------ELMSREDVTKDADLS--PVNASIIKENYE-KDEDFLSSTRNTNIL-------PT 512
Query: 352 QEE----LDQRFDEILAVDKED--IVKKWKEEIGSDKEILVAEIKKLE---GLGISLEGT 402
+EE L +EI K++ ++ KW+ +G + EI+VA + K GLGISLE T
Sbjct: 513 EEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEAT 572
Query: 403 VDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP 462
V HH+IRSVLP+GPVG G L +GDELLEVN L G H +VVNILK+LP
Sbjct: 573 VG---------HHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELP 623
Query: 463 DRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTSSTA 522
V +VC R ++ P D S L ++ K D S+
Sbjct: 624 IEVTMVCCRRTVP----PTTQSELD----------SLDLCDIELTEKPHVDLGEFIGSSE 669
Query: 523 TLTNHSEQSKKSRSLECVSG-LAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIV 581
T + +S E V LAMW++ + L K +GLGFSILDYQDP+DP TVI+
Sbjct: 670 TEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPASTVII 729
Query: 582 VRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPLP 640
+RSLVPGG+AEK+G + PGDR+M VN V+++N++L++AV+ALKGAP GTV++G+A+PLP
Sbjct: 730 IRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLP 788
Score = 114 bits (275), Expect = 8e-25
Identities = 49/86 (56%), Positives = 68/86 (79%)
Query: 7 WAQVEVVELTNDGNGLGFNLVGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLR 66
W +E +EL NDG+GLGF ++GG++TGV++K +LPGGVAD+ RL SGDH+L++G +L
Sbjct: 252 WQHMETIELVNDGSGLGFGIIGGKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLA 311
Query: 67 GFTSEQVAAVLRQAGPVVRLLVARPA 92
G +SEQVA VLRQ G V+L++AR A
Sbjct: 312 GMSSEQVAQVLRQCGNRVKLMIARGA 337
Score = 111 bits (267), Expect = 8e-24
Identities = 118/438 (26%), Positives = 197/438 (44%), Gaps = 55/438 (12%)
Query: 220 EELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
E + GIF+K ++E S A ++G +K DRI+EVDG+ L D S+ Q+VE +R G V ++
Sbjct: 1180 EVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMV 1239
Query: 280 ERYLRGPKFEHLQLAIFNEERXXXXXXXXXXLSWFPVPSQLENSITEIEPEPESNTTI-- 337
+ + P+ L + N + + S +E EPE ++
Sbjct: 1240 QSIINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADKAPSQSESEPEKAPLCSVPP 1299
Query: 338 --DSSVLEVGDLQEPTQEELDQRFDEILAVDKED-IVKKWK---EEIGS-DKEILVAEIK 390
S+ E+G + TQ + + VDKED WK E G+ E+ + E++
Sbjct: 1300 PPPSAFAEMG--SDHTQSSASKISQD---VDKEDEFGYSWKNIRERYGTLTGELHMIELE 1354
Query: 391 K-LEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K GLG+SL G D R +I + P+G G G L DELLE+N L+G
Sbjct: 1355 KGHSGLGLSLAGNKD-----RSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGR 1409
Query: 450 THSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVK 509
+H +I+K P +V+++ RN + VN + G + S S N L
Sbjct: 1410 SHQNASSIIKCAPSKVKIIFIRN------KDAVNQMAVCPGNAVEPLPSNSEN----LQN 1459
Query: 510 AQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDY 569
+++ ++ TS A K + LE L K GLG +I +
Sbjct: 1460 KETEPTVTTSDAAV---DLSSFKNVQHLE----------------LPKDQGGLGIAISE- 1499
Query: 570 QDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRG 629
+D + + ++++SL GVA +G + GD++++V+ + +++ + LK A +
Sbjct: 1500 EDTL----SGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTA-KM 1554
Query: 630 TVKVGIARPLPPQDSSKS 647
TVK+ I P + S
Sbjct: 1555 TVKLTIHAENPDSQAVPS 1572
Score = 68.9 bits (161), Expect = 5e-11
Identities = 72/272 (26%), Positives = 115/272 (42%), Gaps = 26/272 (9%)
Query: 13 VELTNDGNGLGFNLVGG------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLR 66
VELT + GLG + G +G+ +K + + D R+Q GD ++ V NL+
Sbjct: 378 VELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQ 437
Query: 67 GFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVPTKILADPELLDRHLIET 126
GFT++Q VLR G V L + R A + TK AD ++ +I+
Sbjct: 438 GFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDV----TKD-ADLSPVNASIIKE 492
Query: 127 GYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQKIPDHPIVCDSVSPTITIT 186
Y D + NI E +++A + I D QK + + I
Sbjct: 493 NYEKDEDFLSSTRNTNIL-PTEEEGYPLLSAEIEEIED-AQK--QEAALLTKWQRIMGIN 548
Query: 187 VPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKIND 246
EI + HV GLGI++ V F++S++ SGK+ D
Sbjct: 549 Y-----EIVVAHVSKFSENSGLGISLEATVGHH------FIRSVLPEGPVGHSGKLFSGD 597
Query: 247 RIIEVDGISLADKSNPQSVEILRNTGISVHLV 278
++EV+GI+L +++ V IL+ I V +V
Sbjct: 598 ELLEVNGITLLGENHQDVVNILKELPIEVTMV 629
Score = 62.1 bits (144), Expect = 6e-09
Identities = 36/85 (42%), Positives = 50/85 (58%), Gaps = 2/85 (2%)
Query: 19 GNGLGFNLVGGRS-TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAVL 77
G GLG ++VG R+ TGV + ++ GG+AD D RL GD +L V ++R T E VAA+L
Sbjct: 1733 GKGLGLSIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALL 1792
Query: 78 RQAGPVVRLLVAR-PADPATALRAP 101
+ + V L V R A P + R P
Sbjct: 1793 KCSLGTVTLEVGRIKAGPFHSERRP 1817
Score = 59.3 bits (137), Expect = 4e-08
Identities = 67/285 (23%), Positives = 120/285 (42%), Gaps = 29/285 (10%)
Query: 379 GSDKEILVAEI-KKLEGLGISLEGTVDVEGGQELRPHH-YIRSVLPDGPVGLQGVLNAGD 436
G + E E+ K ++GLGI++ G + G ++L P +++S+ V G + GD
Sbjct: 370 GEESETFDVELTKNVQGLGITIAGYI---GDKKLEPSGIFVKSITKSSAVEHDGRIQIGD 426
Query: 437 ELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGP----RPVVNLASDREGFE 492
+++ V+ L G T+ + V +L+ V L R + R V +D
Sbjct: 427 QIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVN 486
Query: 493 ARKIISGSLNNLTTLVKAQSDTSI---NTSSTATLTNHSEQSKKSRSLECVSGLAMWQ-- 547
A II + + + +T+I L+ E+ + ++ E L WQ
Sbjct: 487 A-SIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAAL-LTKWQRI 544
Query: 548 ---SKEDIVMLVKA---DQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGD 601
+ E +V V + GLG S+ + V + +RS++P G +G++ GD
Sbjct: 545 MGINYEIVVAHVSKFSENSGLGISL---EATVGHH----FIRSVLPEGPVGHSGKLFSGD 597
Query: 602 RVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPLPPQDSSK 646
++ VNG+++ V LK P V R +PP S+
Sbjct: 598 ELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSE 642
Score = 59.3 bits (137), Expect = 4e-08
Identities = 58/206 (28%), Positives = 95/206 (46%), Gaps = 23/206 (11%)
Query: 8 AQVEVVELTNDGNGLGFNL------VGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVG 61
A ++ +EL GLGF++ + ST ++I+ ++PGG+A+KD RL GD ++ V
Sbjct: 696 AGIQHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVN 755
Query: 62 SVNLRGFTSEQVAAVLRQA-GPVVRLLVAR--PADPATALRAPQPGTALVPTKI-----L 113
VNL + E+ L+ A VR+ VA+ P P + + + L P L
Sbjct: 756 DVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSPEEGYVSAKEDSFLYPPHSCEEAGL 815
Query: 114 ADPELL--DRHLIETGYGAVYDLSQCYSDYN-INGQNGETETSIVAAAVSVIGDN---PQ 167
AD L D L+ T + D S S Y+ N T+ SI++ S GD
Sbjct: 816 ADKPLFRADLALVGTNDADLVDESTFESPYSPENDSIYSTQASILSLHGSSCGDGLNYGS 875
Query: 168 KIPDHP---IVCDSVSPTITITVPVE 190
+P P ++ +S P + + + +E
Sbjct: 876 SLPSSPPKDVIENSCDPVLDLHMSLE 901
Score = 57.6 bits (133), Expect = 1e-07
Identities = 32/85 (37%), Positives = 47/85 (55%), Gaps = 3/85 (3%)
Query: 13 VELTNDGNGLGFNLVGGRST---GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFT 69
+E++ GLG ++VGG T ++I V G A KD RL +GD +L+V ++LR T
Sbjct: 1630 IEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKAT 1689
Query: 70 SEQVAAVLRQAGPVVRLLVARPADP 94
++ VLRQ VRL + R P
Sbjct: 1690 HDEAINVLRQTPQRVRLTLYRDEAP 1714
Score = 57.2 bits (132), Expect = 2e-07
Identities = 63/278 (22%), Positives = 119/278 (42%), Gaps = 26/278 (9%)
Query: 377 EIGSDKEILVAEIKKLEG-LGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAG 435
++ S K + E+ K +G LGI++ + G I+S+ G G L G
Sbjct: 1474 DLSSFKNVQHLELPKDQGGLGIAISEEDTLSGV-------IIKSLTEHGVAATDGRLKVG 1526
Query: 436 DELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARK 495
D++L V++ + G + +++LK V+L + DS P A+ E
Sbjct: 1527 DQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGE------ 1580
Query: 496 IISGSLNNLTTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVML 555
N+ +L+ QS + ++ N S S + + + E + +
Sbjct: 1581 ----KKNSSQSLMVPQS----GSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEI 1632
Query: 556 VKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNAT 615
K GLG SI+ D + I++ + G A K+G + GD+++ VNG+ ++ AT
Sbjct: 1633 SKGRTGLGLSIVGGSDTLLG---AIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKAT 1689
Query: 616 LDQAVQALKGAPRGTVKVGIARPLPPQDSSKSKGTINV 653
D+A+ L+ P+ V++ + R P + T+ +
Sbjct: 1690 HDEAINVLRQTPQ-RVRLTLYRDEAPYKEEEVCDTLTI 1726
Score = 54.8 bits (126), Expect = 9e-07
Identities = 68/263 (25%), Positives = 113/263 (42%), Gaps = 34/263 (12%)
Query: 374 WKEEIGSDKEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLN 433
+KEE D + + K +GLG+S+ G + G ++ ++ G G L
Sbjct: 1715 YKEEEVCDTLTIELQKKPGKGLGLSIVGKRNDTGV-------FVSDIVKGGIADADGRLM 1767
Query: 434 AGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEA 493
GD++L VN + T V +LK V L R I +GP S+R ++
Sbjct: 1768 QGDQILMVNGEDVRNATQEAVAALLKCSLGTVTLEVGR--IKAGP-----FHSERRPSQS 1820
Query: 494 RKIISGSLNNLTTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIV 553
++ GSL++ T S ++T + SKK+ + GL + K+
Sbjct: 1821 SQVSEGSLSSFT----------FPLSGSSTSESLESSSKKNALASEIQGLRTVEMKKG-- 1868
Query: 554 MLVKADQGLGFSILDYQDPVDPNGTV-IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
LG SI P G V I + + P GVA + ++ GDR++++ G S +
Sbjct: 1869 ----PTDSLGISIAGGVG--SPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTE 1922
Query: 613 NATLDQAVQALKGAPRGTVKVGI 635
T QAV LK A G++++ +
Sbjct: 1923 GMTHTQAVNLLKNA-SGSIEMQV 1944
Score = 53.2 bits (122), Expect = 3e-06
Identities = 30/81 (37%), Positives = 47/81 (58%), Gaps = 6/81 (7%)
Query: 557 KADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATL 616
K +GLG SI+ + N T + V +V GG+A+ +G + GD+++ VNG ++NAT
Sbjct: 1731 KPGKGLGLSIVGKR-----NDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNAT- 1784
Query: 617 DQAVQALKGAPRGTVKVGIAR 637
+AV AL GTV + + R
Sbjct: 1785 QEAVAALLKCSLGTVTLEVGR 1805
Score = 52.4 bits (120), Expect = 5e-06
Identities = 28/85 (32%), Positives = 46/85 (54%), Gaps = 5/85 (5%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDHVLQVGSV 63
Q + + L +GLGF++VGG + + +K V G A +D RL+ GD ++ V
Sbjct: 1984 QCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQ 2043
Query: 64 NLRGFTSEQVAAVLRQAGPVVRLLV 88
+L G T E+ A+L++ V L+V
Sbjct: 2044 SLEGVTHEEAVAILKRTKGTVTLMV 2068
Score = 52.0 bits (119), Expect = 6e-06
Identities = 43/170 (25%), Positives = 82/170 (48%), Gaps = 17/170 (10%)
Query: 463 DRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTSSTA 522
DR+ +C ++ VNL + G ++++G +++ + Q + + ++ S
Sbjct: 1911 DRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGG--DVSVVTGHQQEPASSSLSFT 1968
Query: 523 TLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTV-IV 581
LT+ S +C S + L + GLGFSI+ P+G + I
Sbjct: 1969 GLTSSSIFQDDLGPPQCKS-----------ITLERGPDGLGFSIVGGYG--SPHGDLPIY 2015
Query: 582 VRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTV 631
V+++ G A ++G + GD++++VNG S++ T ++AV LK +GTV
Sbjct: 2016 VKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILK-RTKGTV 2064
Score = 50.4 bits (115), Expect = 2e-05
Identities = 28/76 (36%), Positives = 45/76 (59%), Gaps = 1/76 (1%)
Query: 207 GLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADK-SNPQSV 265
GLG +V G E GIFV+ I EGS A + G++K D+I+ ++G +L ++ Q++
Sbjct: 147 GLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAI 206
Query: 266 EILRNTGISVHLVLER 281
IL+ +V LV+ R
Sbjct: 207 SILQKAKDTVQLVIAR 222
Score = 50.4 bits (115), Expect = 2e-05
Identities = 39/122 (31%), Positives = 61/122 (50%), Gaps = 12/122 (9%)
Query: 163 GDNPQKIPDHPIVCDSVSPTITITV---PVELPEIEIIHVDLNKNVYGLGITVAGYVCEK 219
G PQ + PIV S S TI+ PV +E I +L + GLG + G
Sbjct: 223 GSLPQLVS--PIVSRSPSAASTISAHSNPVHWQHMETI--ELVNDGSGLGFGIIG----- 273
Query: 220 EELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
+ +G+ VK+I+ G A+Q G++ D I+++ LA S+ Q ++LR G V L++
Sbjct: 274 GKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMI 333
Query: 280 ER 281
R
Sbjct: 334 AR 335
Score = 50.4 bits (115), Expect = 2e-05
Identities = 31/110 (28%), Positives = 53/110 (48%), Gaps = 8/110 (7%)
Query: 528 SEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVP 587
S + ++ S WQ E I LV GLGF I + T ++V++++P
Sbjct: 234 SRSPSAASTISAHSNPVHWQHMETIE-LVNDGSGLGFGI------IGGKATGVIVKTILP 286
Query: 588 GGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIAR 637
GGVA+++G + GD ++ + + + +Q Q L+ VK+ IAR
Sbjct: 287 GGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQC-GNRVKLMIAR 335
Score = 50.4 bits (115), Expect = 2e-05
Identities = 27/94 (28%), Positives = 52/94 (55%), Gaps = 1/94 (1%)
Query: 177 DSVSPTITITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSG-IFVKSIIEGSS 235
D+ T + P+ + E I H++L K GLG ++ Y + S I ++S++ G
Sbjct: 679 DAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGI 738
Query: 236 AEQSGKIKINDRIIEVDGISLADKSNPQSVEILR 269
AE+ G++ DR++ V+ ++L + S ++VE L+
Sbjct: 739 AEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALK 772
Score = 50.0 bits (114), Expect = 3e-05
Identities = 67/297 (22%), Positives = 129/297 (43%), Gaps = 29/297 (9%)
Query: 5 TEWAQVEVVELTND-GNGLGFNLVGGRSTG-----------VVIKYVLPGGVADKDRRLQ 52
+ W Q VEL + LG ++VGGR G + IK+VL A K+ L+
Sbjct: 1144 SNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLK 1203
Query: 53 SGDHVLQVGSVNLRGFTSEQVAAVLRQAG-PV---VRLLVARP--ADPATALRAPQPGTA 106
GD +++V ++LR + EQ +R+AG PV V+ ++ RP + + L P
Sbjct: 1204 PGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYN 1263
Query: 107 LVPTKILADPELLDRHLIETGYGAVYDLSQ-CYSDYNINGQNGETETSIVAAAVSVIGDN 165
T AD ++ + + + + C E + ++ S I +
Sbjct: 1264 FSSTNPFADSLQINADKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQD 1323
Query: 166 PQKIPDHPIVCDSVSPTI-TITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSG 224
K + ++ T+T + + E+E H L G+++AG ++ +S
Sbjct: 1324 VDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGL-------GLSLAGNK-DRSRMS- 1374
Query: 225 IFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
+F+ I +A + G+++I D ++E++G L +S+ + I++ V ++ R
Sbjct: 1375 VFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIR 1431
Score = 50.0 bits (114), Expect = 3e-05
Identities = 28/104 (26%), Positives = 54/104 (51%), Gaps = 4/104 (3%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTGVVIKYVL---PGGVADKDRRLQSGDHVLQVGSVNL 65
++ ++EL +GLG +L G + + +++ P G A KD RLQ D +L++ L
Sbjct: 1347 ELHMIELEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQIL 1406
Query: 66 RGFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVP 109
G + + +++++ A V+++ R D + A PG A+ P
Sbjct: 1407 YGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQM-AVCPGNAVEP 1449
Score = 50.0 bits (114), Expect = 3e-05
Identities = 29/101 (28%), Positives = 57/101 (56%), Gaps = 6/101 (5%)
Query: 181 PTITIT-VPVELPEIEII-HVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQ 238
PT+T + V+L + + H++L K+ GLGI ++ E++ LSG+ +KS+ E A
Sbjct: 1464 PTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAIS----EEDTLSGVIIKSLTEHGVAAT 1519
Query: 239 SGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
G++K+ D+I+ VD + + + +L+ ++V L +
Sbjct: 1520 DGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTI 1560
Score = 48.8 bits (111), Expect = 6e-05
Identities = 36/125 (28%), Positives = 58/125 (46%), Gaps = 5/125 (4%)
Query: 503 NLTTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDI-VMLVKADQG 561
N L+ A+ T+ TA S + L + + E V L K QG
Sbjct: 327 NRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQKGEESETFDVELTKNVQG 386
Query: 562 LGFSILDY--QDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQA 619
LG +I Y ++P+G I V+S+ E +G I GD++++V+G ++Q T QA
Sbjct: 387 LGITIAGYIGDKKLEPSG--IFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQA 444
Query: 620 VQALK 624
V+ L+
Sbjct: 445 VEVLR 449
Score = 47.6 bits (108), Expect = 1e-04
Identities = 30/106 (28%), Positives = 54/106 (50%), Gaps = 4/106 (3%)
Query: 178 SVSPTITITVPVELPEIEIIH--VDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSS 235
S +P I + P P I ++++K GLG+++ G L I + + E +
Sbjct: 1607 SSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGG--SDTLLGAIIIHEVYEEGA 1664
Query: 236 AEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
A + G++ D+I+EV+GI L ++ +++ +LR T V L L R
Sbjct: 1665 ACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYR 1710
Score = 47.2 bits (107), Expect = 2e-04
Identities = 20/64 (31%), Positives = 39/64 (60%)
Query: 417 IRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDS 476
++++LP G G L +GD +L++ + L G++ +V +L+Q +RV+L+ AR +I+
Sbjct: 281 VKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARGAIEE 340
Query: 477 GPRP 480
P
Sbjct: 341 RTAP 344
Score = 46.4 bits (105), Expect = 3e-04
Identities = 35/138 (25%), Positives = 69/138 (50%), Gaps = 3/138 (2%)
Query: 143 INGQNGETETSIVAAA-VSVIGDNPQKIPDHPIVCDSVSPTITITVPVELPEIEIIHVDL 201
+ +G E +VA VSV+ + Q+ + ++ + + P+ + I ++
Sbjct: 1933 LKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKSITLER 1992
Query: 202 NKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSN 261
+ G I V GY +L I+VK++ +A + G++K D+II V+G SL ++
Sbjct: 1993 GPDGLGFSI-VGGYGSPHGDLP-IYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTH 2050
Query: 262 PQSVEILRNTGISVHLVL 279
++V IL+ T +V L++
Sbjct: 2051 EEAVAILKRTKGTVTLMV 2068
Score = 46.0 bits (104), Expect = 4e-04
Identities = 31/107 (28%), Positives = 58/107 (54%), Gaps = 5/107 (4%)
Query: 538 ECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTV-IVVRSLVPGGVAEKNGE 596
+ + +A + E +L GLGFS++ + + G + I V+ + G VA ++G
Sbjct: 124 QLIKNMAQGRHVEVFELLKPPSGGLGFSVVGLRS--ENRGELGIFVQEIQEGSVAHRDGR 181
Query: 597 ISPGDRVMSVNGVSI-QNATLDQAVQALKGAPRGTVKVGIARPLPPQ 642
+ D+++++NG ++ Q T QA+ L+ A + TV++ IAR PQ
Sbjct: 182 LKETDQILAINGQALDQTITHQQAISILQKA-KDTVQLVIARGSLPQ 227
Score = 44.0 bits (99), Expect = 0.002
Identities = 27/85 (31%), Positives = 46/85 (54%), Gaps = 1/85 (1%)
Query: 5 TEWAQVEVVELTNDGNGLGFNLVGGRS-TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSV 63
+ + V+ +EL D GLG + + +GV+IK + GVA D RL+ GD +L V
Sbjct: 1476 SSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDE 1535
Query: 64 NLRGFTSEQVAAVLRQAGPVVRLLV 88
+ G+ E+ ++L+ A V+L +
Sbjct: 1536 IVVGYPIEKFISLLKTAKMTVKLTI 1560
Score = 43.6 bits (98), Expect = 0.002
Identities = 27/76 (35%), Positives = 38/76 (50%), Gaps = 3/76 (3%)
Query: 393 EGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHS 452
+GLG S+ G G P Y+++V G G L GD+++ VN L G+TH
Sbjct: 1995 DGLGFSIVGGYGSPHGD--LPI-YVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHE 2051
Query: 453 EVVNILKQLPDRVRLV 468
E V ILK+ V L+
Sbjct: 2052 EAVAILKRTKGTVTLM 2067
Score = 42.3 bits (95), Expect = 0.005
Identities = 29/97 (29%), Positives = 50/97 (51%), Gaps = 6/97 (6%)
Query: 529 EQSKKSRSLECVS-GLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVP 587
EQS + + ECV +S E + + K + LG ++ +D G ++VRS++
Sbjct: 984 EQSSLACNAECVMLQNVSKESFERTINIAKGNSSLGMTVSANKD-----GLGMIVRSIIH 1038
Query: 588 GGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
GG ++G I+ GD ++S+N S + T QA L+
Sbjct: 1039 GGAISRDGRIAIGDCILSINEESTISVTNAQARAMLR 1075
Score = 39.1 bits (87), Expect = 0.049
Identities = 21/70 (30%), Positives = 38/70 (54%)
Query: 208 LGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEI 267
LGI++AG V IF+ + A Q+ K+++ DRI+ + G S ++ Q+V +
Sbjct: 1873 LGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNL 1932
Query: 268 LRNTGISVHL 277
L+N S+ +
Sbjct: 1933 LKNASGSIEM 1942
Score = 38.7 bits (86), Expect = 0.064
Identities = 22/80 (27%), Positives = 43/80 (53%), Gaps = 4/80 (5%)
Query: 207 GLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVE 266
GLG+++ G K +G+FV I++G A+ G++ D+I+ V+G + + +
Sbjct: 1735 GLGLSIVG----KRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAA 1790
Query: 267 ILRNTGISVHLVLERYLRGP 286
+L+ + +V L + R GP
Sbjct: 1791 LLKCSLGTVTLEVGRIKAGP 1810
Score = 37.9 bits (84), Expect = 0.11
Identities = 27/91 (29%), Positives = 45/91 (49%), Gaps = 4/91 (4%)
Query: 394 GLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRL-HGLTHS 452
GLG S+ G G EL +++ + G L D++L +N L +TH
Sbjct: 147 GLGFSVVGLRSENRG-ELGI--FVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQ 203
Query: 453 EVVNILKQLPDRVRLVCARNSIDSGPRPVVN 483
+ ++IL++ D V+LV AR S+ P+V+
Sbjct: 204 QAISILQKAKDTVQLVIARGSLPQLVSPIVS 234
Score = 37.5 bits (83), Expect = 0.15
Identities = 31/137 (22%), Positives = 58/137 (42%), Gaps = 4/137 (2%)
Query: 199 VDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLAD 258
+++ K LG+TV+ K+ L G+ V+SII G + + G+I I D I+ ++ S
Sbjct: 1009 INIAKGNSSLGMTVSA---NKDGL-GMIVRSIIHGGAISRDGRIAIGDCILSINEESTIS 1064
Query: 259 KSNPQSVEILRNTGISVHLVLERYLRGPKFEHLQLAIFNEERXXXXXXXXXXLSWFPVPS 318
+N Q+ +LR + + Y+ E ++++ + + +P
Sbjct: 1065 VTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDIPE 1124
Query: 319 QLENSITEIEPEPESNT 335
E E E NT
Sbjct: 1125 LPEREEGEGEESELQNT 1141
Score = 35.9 bits (79), Expect = 0.45
Identities = 23/80 (28%), Positives = 35/80 (43%), Gaps = 3/80 (3%)
Query: 17 NDGNGLGFNLVGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAV 76
N G G+ G I+ VLP G +L SGD +L+V + L G + V +
Sbjct: 562 NSGLGISLEATVGHH---FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNI 618
Query: 77 LRQAGPVVRLLVARPADPAT 96
L++ V ++ R P T
Sbjct: 619 LKELPIEVTMVCCRRTVPPT 638
Score = 33.9 bits (74), Expect = 1.8
Identities = 23/97 (23%), Positives = 45/97 (46%), Gaps = 6/97 (6%)
Query: 3 LSTEWAQVEVVELTNDG-NGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDH 56
L++E + VE+ + LG ++ GG + + I + P GVA + ++L+ GD
Sbjct: 1853 LASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDR 1912
Query: 57 VLQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVARPAD 93
++ + + G T Q +L+ A + + V D
Sbjct: 1913 IVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGD 1949
>AL162386-2|CAH71899.1| 2070|Homo sapiens multiple PDZ domain
protein protein.
Length = 2070
Score = 293 bits (718), Expect = 2e-78
Identities = 201/479 (41%), Positives = 275/479 (57%), Gaps = 58/479 (12%)
Query: 178 SVSPTITITVPVELP-----EIEIIHVDLNKNVYGLGITVAGYVCEKE-ELSGIFVKSII 231
S SPT T + V+ E E V+L KNV GLGIT+AGY+ +K+ E SGIFVKSI
Sbjct: 352 SSSPTSTPELRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSIT 411
Query: 232 EGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHL 291
+ S+ E G+I+I D+II VDG +L +N Q+VE+LR+TG +V L L R RG K E
Sbjct: 412 KSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMR--RGMKQEA- 468
Query: 292 QLAIFNEERXXXXXXXXXXLSWFPVPSQLENSITEIEPEPESNTTIDSSVLEVGDLQEPT 351
E LS PV + + E + E ++T ++++L PT
Sbjct: 469 ------ELMSREDVTKDADLS--PVNASIIKENYE-KDEDFLSSTRNTNIL-------PT 512
Query: 352 QEE----LDQRFDEILAVDKED--IVKKWKEEIGSDKEILVAEIKKLE---GLGISLEGT 402
+EE L +EI K++ ++ KW+ +G + EI+VA + K GLGISLE T
Sbjct: 513 EEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEAT 572
Query: 403 VDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP 462
V HH+IRSVLP+GPVG G L +GDELLEVN L G H +VVNILK+LP
Sbjct: 573 VG---------HHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELP 623
Query: 463 DRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTSSTA 522
V +VC R ++ P D S L ++ K D S+
Sbjct: 624 IEVTMVCCRRTVP----PTTQSELD----------SLDLCDIELTEKPHVDLGEFIGSSE 669
Query: 523 TLTNHSEQSKKSRSLECVSG-LAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIV 581
T + +S E V LAMW++ + L K +GLGFSILDYQDP+DP TVI+
Sbjct: 670 TEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPASTVII 729
Query: 582 VRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPLP 640
+RSLVPGG+AEK+G + PGDR+M VN V+++N++L++AV+ALKGAP GTV++G+A+PLP
Sbjct: 730 IRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLP 788
Score = 114 bits (275), Expect = 8e-25
Identities = 49/86 (56%), Positives = 68/86 (79%)
Query: 7 WAQVEVVELTNDGNGLGFNLVGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLR 66
W +E +EL NDG+GLGF ++GG++TGV++K +LPGGVAD+ RL SGDH+L++G +L
Sbjct: 252 WQHMETIELVNDGSGLGFGIIGGKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLA 311
Query: 67 GFTSEQVAAVLRQAGPVVRLLVARPA 92
G +SEQVA VLRQ G V+L++AR A
Sbjct: 312 GMSSEQVAQVLRQCGNRVKLMIARGA 337
Score = 111 bits (267), Expect = 8e-24
Identities = 118/438 (26%), Positives = 197/438 (44%), Gaps = 55/438 (12%)
Query: 220 EELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
E + GIF+K ++E S A ++G +K DRI+EVDG+ L D S+ Q+VE +R G V ++
Sbjct: 1180 EVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMV 1239
Query: 280 ERYLRGPKFEHLQLAIFNEERXXXXXXXXXXLSWFPVPSQLENSITEIEPEPESNTTI-- 337
+ + P+ L + N + + S +E EPE ++
Sbjct: 1240 QSIINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADKAPSQSESEPEKAPLCSVPP 1299
Query: 338 --DSSVLEVGDLQEPTQEELDQRFDEILAVDKED-IVKKWK---EEIGS-DKEILVAEIK 390
S+ E+G + TQ + + VDKED WK E G+ E+ + E++
Sbjct: 1300 PPPSAFAEMG--SDHTQSSASKISQD---VDKEDEFGYSWKNIRERYGTLTGELHMIELE 1354
Query: 391 K-LEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K GLG+SL G D R +I + P+G G G L DELLE+N L+G
Sbjct: 1355 KGHSGLGLSLAGNKD-----RSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGR 1409
Query: 450 THSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVK 509
+H +I+K P +V+++ RN + VN + G + S S N L
Sbjct: 1410 SHQNASSIIKCAPSKVKIIFIRN------KDAVNQMAVCPGNAVEPLPSNSEN----LQN 1459
Query: 510 AQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDY 569
+++ ++ TS A K + LE L K GLG +I +
Sbjct: 1460 KETEPTVTTSDAAV---DLSSFKNVQHLE----------------LPKDQGGLGIAISE- 1499
Query: 570 QDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRG 629
+D + + ++++SL GVA +G + GD++++V+ + +++ + LK A +
Sbjct: 1500 EDTL----SGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTA-KM 1554
Query: 630 TVKVGIARPLPPQDSSKS 647
TVK+ I P + S
Sbjct: 1555 TVKLTIHAENPDSQAVPS 1572
Score = 68.9 bits (161), Expect = 5e-11
Identities = 72/272 (26%), Positives = 115/272 (42%), Gaps = 26/272 (9%)
Query: 13 VELTNDGNGLGFNLVGG------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLR 66
VELT + GLG + G +G+ +K + + D R+Q GD ++ V NL+
Sbjct: 378 VELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQ 437
Query: 67 GFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVPTKILADPELLDRHLIET 126
GFT++Q VLR G V L + R A + TK AD ++ +I+
Sbjct: 438 GFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDV----TKD-ADLSPVNASIIKE 492
Query: 127 GYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQKIPDHPIVCDSVSPTITIT 186
Y D + NI E +++A + I D QK + + I
Sbjct: 493 NYEKDEDFLSSTRNTNIL-PTEEEGYPLLSAEIEEIED-AQK--QEAALLTKWQRIMGIN 548
Query: 187 VPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKIND 246
EI + HV GLGI++ V F++S++ SGK+ D
Sbjct: 549 Y-----EIVVAHVSKFSENSGLGISLEATVGHH------FIRSVLPEGPVGHSGKLFSGD 597
Query: 247 RIIEVDGISLADKSNPQSVEILRNTGISVHLV 278
++EV+GI+L +++ V IL+ I V +V
Sbjct: 598 ELLEVNGITLLGENHQDVVNILKELPIEVTMV 629
Score = 62.1 bits (144), Expect = 6e-09
Identities = 36/85 (42%), Positives = 50/85 (58%), Gaps = 2/85 (2%)
Query: 19 GNGLGFNLVGGRS-TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAVL 77
G GLG ++VG R+ TGV + ++ GG+AD D RL GD +L V ++R T E VAA+L
Sbjct: 1733 GKGLGLSIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALL 1792
Query: 78 RQAGPVVRLLVAR-PADPATALRAP 101
+ + V L V R A P + R P
Sbjct: 1793 KCSLGTVTLEVGRIKAGPFHSERRP 1817
Score = 59.3 bits (137), Expect = 4e-08
Identities = 67/285 (23%), Positives = 120/285 (42%), Gaps = 29/285 (10%)
Query: 379 GSDKEILVAEI-KKLEGLGISLEGTVDVEGGQELRPHH-YIRSVLPDGPVGLQGVLNAGD 436
G + E E+ K ++GLGI++ G + G ++L P +++S+ V G + GD
Sbjct: 370 GEESETFDVELTKNVQGLGITIAGYI---GDKKLEPSGIFVKSITKSSAVEHDGRIQIGD 426
Query: 437 ELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGP----RPVVNLASDREGFE 492
+++ V+ L G T+ + V +L+ V L R + R V +D
Sbjct: 427 QIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVN 486
Query: 493 ARKIISGSLNNLTTLVKAQSDTSI---NTSSTATLTNHSEQSKKSRSLECVSGLAMWQ-- 547
A II + + + +T+I L+ E+ + ++ E L WQ
Sbjct: 487 A-SIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAAL-LTKWQRI 544
Query: 548 ---SKEDIVMLVKA---DQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGD 601
+ E +V V + GLG S+ + V + +RS++P G +G++ GD
Sbjct: 545 MGINYEIVVAHVSKFSENSGLGISL---EATVGHH----FIRSVLPEGPVGHSGKLFSGD 597
Query: 602 RVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPLPPQDSSK 646
++ VNG+++ V LK P V R +PP S+
Sbjct: 598 ELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSE 642
Score = 59.3 bits (137), Expect = 4e-08
Identities = 58/206 (28%), Positives = 95/206 (46%), Gaps = 23/206 (11%)
Query: 8 AQVEVVELTNDGNGLGFNL------VGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVG 61
A ++ +EL GLGF++ + ST ++I+ ++PGG+A+KD RL GD ++ V
Sbjct: 696 AGIQHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVN 755
Query: 62 SVNLRGFTSEQVAAVLRQA-GPVVRLLVAR--PADPATALRAPQPGTALVPTKI-----L 113
VNL + E+ L+ A VR+ VA+ P P + + + L P L
Sbjct: 756 DVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSPEEGYVSAKEDSFLYPPHSCEEAGL 815
Query: 114 ADPELL--DRHLIETGYGAVYDLSQCYSDYN-INGQNGETETSIVAAAVSVIGDN---PQ 167
AD L D L+ T + D S S Y+ N T+ SI++ S GD
Sbjct: 816 ADKPLFRADLALVGTNDADLVDESTFESPYSPENDSIYSTQASILSLHGSSCGDGLNYGS 875
Query: 168 KIPDHP---IVCDSVSPTITITVPVE 190
+P P ++ +S P + + + +E
Sbjct: 876 SLPSSPPKDVIENSCDPVLDLHMSLE 901
Score = 57.6 bits (133), Expect = 1e-07
Identities = 32/85 (37%), Positives = 47/85 (55%), Gaps = 3/85 (3%)
Query: 13 VELTNDGNGLGFNLVGGRST---GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFT 69
+E++ GLG ++VGG T ++I V G A KD RL +GD +L+V ++LR T
Sbjct: 1630 IEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKAT 1689
Query: 70 SEQVAAVLRQAGPVVRLLVARPADP 94
++ VLRQ VRL + R P
Sbjct: 1690 HDEAINVLRQTPQRVRLTLYRDEAP 1714
Score = 57.2 bits (132), Expect = 2e-07
Identities = 63/278 (22%), Positives = 119/278 (42%), Gaps = 26/278 (9%)
Query: 377 EIGSDKEILVAEIKKLEG-LGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAG 435
++ S K + E+ K +G LGI++ + G I+S+ G G L G
Sbjct: 1474 DLSSFKNVQHLELPKDQGGLGIAISEEDTLSGV-------IIKSLTEHGVAATDGRLKVG 1526
Query: 436 DELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARK 495
D++L V++ + G + +++LK V+L + DS P A+ E
Sbjct: 1527 DQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGE------ 1580
Query: 496 IISGSLNNLTTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVML 555
N+ +L+ QS + ++ N S S + + + E + +
Sbjct: 1581 ----KKNSSQSLMVPQS----GSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEI 1632
Query: 556 VKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNAT 615
K GLG SI+ D + I++ + G A K+G + GD+++ VNG+ ++ AT
Sbjct: 1633 SKGRTGLGLSIVGGSDTLLG---AIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKAT 1689
Query: 616 LDQAVQALKGAPRGTVKVGIARPLPPQDSSKSKGTINV 653
D+A+ L+ P+ V++ + R P + T+ +
Sbjct: 1690 HDEAINVLRQTPQ-RVRLTLYRDEAPYKEEEVCDTLTI 1726
Score = 54.8 bits (126), Expect = 9e-07
Identities = 68/263 (25%), Positives = 113/263 (42%), Gaps = 34/263 (12%)
Query: 374 WKEEIGSDKEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLN 433
+KEE D + + K +GLG+S+ G + G ++ ++ G G L
Sbjct: 1715 YKEEEVCDTLTIELQKKPGKGLGLSIVGKRNDTGV-------FVSDIVKGGIADADGRLM 1767
Query: 434 AGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEA 493
GD++L VN + T V +LK V L R I +GP S+R ++
Sbjct: 1768 QGDQILMVNGEDVRNATQEAVAALLKCSLGTVTLEVGR--IKAGP-----FHSERRPSQS 1820
Query: 494 RKIISGSLNNLTTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIV 553
++ GSL++ T S ++T + SKK+ + GL + K+
Sbjct: 1821 SQVSEGSLSSFT----------FPLSGSSTSESLESSSKKNALASEIQGLRTVEMKKG-- 1868
Query: 554 MLVKADQGLGFSILDYQDPVDPNGTV-IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
LG SI P G V I + + P GVA + ++ GDR++++ G S +
Sbjct: 1869 ----PTDSLGISIAGGVG--SPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTE 1922
Query: 613 NATLDQAVQALKGAPRGTVKVGI 635
T QAV LK A G++++ +
Sbjct: 1923 GMTHTQAVNLLKNA-SGSIEMQV 1944
Score = 53.2 bits (122), Expect = 3e-06
Identities = 30/81 (37%), Positives = 47/81 (58%), Gaps = 6/81 (7%)
Query: 557 KADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATL 616
K +GLG SI+ + N T + V +V GG+A+ +G + GD+++ VNG ++NAT
Sbjct: 1731 KPGKGLGLSIVGKR-----NDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNAT- 1784
Query: 617 DQAVQALKGAPRGTVKVGIAR 637
+AV AL GTV + + R
Sbjct: 1785 QEAVAALLKCSLGTVTLEVGR 1805
Score = 52.4 bits (120), Expect = 5e-06
Identities = 28/85 (32%), Positives = 46/85 (54%), Gaps = 5/85 (5%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDHVLQVGSV 63
Q + + L +GLGF++VGG + + +K V G A +D RL+ GD ++ V
Sbjct: 1984 QCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQ 2043
Query: 64 NLRGFTSEQVAAVLRQAGPVVRLLV 88
+L G T E+ A+L++ V L+V
Sbjct: 2044 SLEGVTHEEAVAILKRTKGTVTLMV 2068
Score = 52.0 bits (119), Expect = 6e-06
Identities = 43/170 (25%), Positives = 82/170 (48%), Gaps = 17/170 (10%)
Query: 463 DRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTSSTA 522
DR+ +C ++ VNL + G ++++G +++ + Q + + ++ S
Sbjct: 1911 DRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGG--DVSVVTGHQQEPASSSLSFT 1968
Query: 523 TLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTV-IV 581
LT+ S +C S + L + GLGFSI+ P+G + I
Sbjct: 1969 GLTSSSIFQDDLGPPQCKS-----------ITLERGPDGLGFSIVGGYG--SPHGDLPIY 2015
Query: 582 VRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTV 631
V+++ G A ++G + GD++++VNG S++ T ++AV LK +GTV
Sbjct: 2016 VKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILK-RTKGTV 2064
Score = 50.4 bits (115), Expect = 2e-05
Identities = 28/76 (36%), Positives = 45/76 (59%), Gaps = 1/76 (1%)
Query: 207 GLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADK-SNPQSV 265
GLG +V G E GIFV+ I EGS A + G++K D+I+ ++G +L ++ Q++
Sbjct: 147 GLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAI 206
Query: 266 EILRNTGISVHLVLER 281
IL+ +V LV+ R
Sbjct: 207 SILQKAKDTVQLVIAR 222
Score = 50.4 bits (115), Expect = 2e-05
Identities = 39/122 (31%), Positives = 61/122 (50%), Gaps = 12/122 (9%)
Query: 163 GDNPQKIPDHPIVCDSVSPTITITV---PVELPEIEIIHVDLNKNVYGLGITVAGYVCEK 219
G PQ + PIV S S TI+ PV +E I +L + GLG + G
Sbjct: 223 GSLPQLVS--PIVSRSPSAASTISAHSNPVHWQHMETI--ELVNDGSGLGFGIIG----- 273
Query: 220 EELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
+ +G+ VK+I+ G A+Q G++ D I+++ LA S+ Q ++LR G V L++
Sbjct: 274 GKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMI 333
Query: 280 ER 281
R
Sbjct: 334 AR 335
Score = 50.4 bits (115), Expect = 2e-05
Identities = 31/110 (28%), Positives = 53/110 (48%), Gaps = 8/110 (7%)
Query: 528 SEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVP 587
S + ++ S WQ E I LV GLGF I + T ++V++++P
Sbjct: 234 SRSPSAASTISAHSNPVHWQHMETIE-LVNDGSGLGFGI------IGGKATGVIVKTILP 286
Query: 588 GGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIAR 637
GGVA+++G + GD ++ + + + +Q Q L+ VK+ IAR
Sbjct: 287 GGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQC-GNRVKLMIAR 335
Score = 50.4 bits (115), Expect = 2e-05
Identities = 27/94 (28%), Positives = 52/94 (55%), Gaps = 1/94 (1%)
Query: 177 DSVSPTITITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSG-IFVKSIIEGSS 235
D+ T + P+ + E I H++L K GLG ++ Y + S I ++S++ G
Sbjct: 679 DAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGI 738
Query: 236 AEQSGKIKINDRIIEVDGISLADKSNPQSVEILR 269
AE+ G++ DR++ V+ ++L + S ++VE L+
Sbjct: 739 AEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALK 772
Score = 50.0 bits (114), Expect = 3e-05
Identities = 67/297 (22%), Positives = 129/297 (43%), Gaps = 29/297 (9%)
Query: 5 TEWAQVEVVELTND-GNGLGFNLVGGRSTG-----------VVIKYVLPGGVADKDRRLQ 52
+ W Q VEL + LG ++VGGR G + IK+VL A K+ L+
Sbjct: 1144 SNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLK 1203
Query: 53 SGDHVLQVGSVNLRGFTSEQVAAVLRQAG-PV---VRLLVARP--ADPATALRAPQPGTA 106
GD +++V ++LR + EQ +R+AG PV V+ ++ RP + + L P
Sbjct: 1204 PGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYN 1263
Query: 107 LVPTKILADPELLDRHLIETGYGAVYDLSQ-CYSDYNINGQNGETETSIVAAAVSVIGDN 165
T AD ++ + + + + C E + ++ S I +
Sbjct: 1264 FSSTNPFADSLQINADKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQD 1323
Query: 166 PQKIPDHPIVCDSVSPTI-TITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSG 224
K + ++ T+T + + E+E H L G+++AG ++ +S
Sbjct: 1324 VDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGL-------GLSLAGNK-DRSRMS- 1374
Query: 225 IFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
+F+ I +A + G+++I D ++E++G L +S+ + I++ V ++ R
Sbjct: 1375 VFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIR 1431
Score = 50.0 bits (114), Expect = 3e-05
Identities = 28/104 (26%), Positives = 54/104 (51%), Gaps = 4/104 (3%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTGVVIKYVL---PGGVADKDRRLQSGDHVLQVGSVNL 65
++ ++EL +GLG +L G + + +++ P G A KD RLQ D +L++ L
Sbjct: 1347 ELHMIELEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQIL 1406
Query: 66 RGFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVP 109
G + + +++++ A V+++ R D + A PG A+ P
Sbjct: 1407 YGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQM-AVCPGNAVEP 1449
Score = 50.0 bits (114), Expect = 3e-05
Identities = 29/101 (28%), Positives = 57/101 (56%), Gaps = 6/101 (5%)
Query: 181 PTITIT-VPVELPEIEII-HVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQ 238
PT+T + V+L + + H++L K+ GLGI ++ E++ LSG+ +KS+ E A
Sbjct: 1464 PTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAIS----EEDTLSGVIIKSLTEHGVAAT 1519
Query: 239 SGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
G++K+ D+I+ VD + + + +L+ ++V L +
Sbjct: 1520 DGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTI 1560
Score = 48.8 bits (111), Expect = 6e-05
Identities = 36/125 (28%), Positives = 58/125 (46%), Gaps = 5/125 (4%)
Query: 503 NLTTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDI-VMLVKADQG 561
N L+ A+ T+ TA S + L + + E V L K QG
Sbjct: 327 NRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQKGEESETFDVELTKNVQG 386
Query: 562 LGFSILDY--QDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQA 619
LG +I Y ++P+G I V+S+ E +G I GD++++V+G ++Q T QA
Sbjct: 387 LGITIAGYIGDKKLEPSG--IFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQA 444
Query: 620 VQALK 624
V+ L+
Sbjct: 445 VEVLR 449
Score = 47.6 bits (108), Expect = 1e-04
Identities = 30/106 (28%), Positives = 54/106 (50%), Gaps = 4/106 (3%)
Query: 178 SVSPTITITVPVELPEIEIIH--VDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSS 235
S +P I + P P I ++++K GLG+++ G L I + + E +
Sbjct: 1607 SSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGG--SDTLLGAIIIHEVYEEGA 1664
Query: 236 AEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
A + G++ D+I+EV+GI L ++ +++ +LR T V L L R
Sbjct: 1665 ACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYR 1710
Score = 47.2 bits (107), Expect = 2e-04
Identities = 20/64 (31%), Positives = 39/64 (60%)
Query: 417 IRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDS 476
++++LP G G L +GD +L++ + L G++ +V +L+Q +RV+L+ AR +I+
Sbjct: 281 VKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARGAIEE 340
Query: 477 GPRP 480
P
Sbjct: 341 RTAP 344
Score = 46.4 bits (105), Expect = 3e-04
Identities = 35/138 (25%), Positives = 69/138 (50%), Gaps = 3/138 (2%)
Query: 143 INGQNGETETSIVAAA-VSVIGDNPQKIPDHPIVCDSVSPTITITVPVELPEIEIIHVDL 201
+ +G E +VA VSV+ + Q+ + ++ + + P+ + I ++
Sbjct: 1933 LKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKSITLER 1992
Query: 202 NKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSN 261
+ G I V GY +L I+VK++ +A + G++K D+II V+G SL ++
Sbjct: 1993 GPDGLGFSI-VGGYGSPHGDLP-IYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTH 2050
Query: 262 PQSVEILRNTGISVHLVL 279
++V IL+ T +V L++
Sbjct: 2051 EEAVAILKRTKGTVTLMV 2068
Score = 46.0 bits (104), Expect = 4e-04
Identities = 31/107 (28%), Positives = 58/107 (54%), Gaps = 5/107 (4%)
Query: 538 ECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTV-IVVRSLVPGGVAEKNGE 596
+ + +A + E +L GLGFS++ + + G + I V+ + G VA ++G
Sbjct: 124 QLIKNMAQGRHVEVFELLKPPSGGLGFSVVGLRS--ENRGELGIFVQEIQEGSVAHRDGR 181
Query: 597 ISPGDRVMSVNGVSI-QNATLDQAVQALKGAPRGTVKVGIARPLPPQ 642
+ D+++++NG ++ Q T QA+ L+ A + TV++ IAR PQ
Sbjct: 182 LKETDQILAINGQALDQTITHQQAISILQKA-KDTVQLVIARGSLPQ 227
Score = 44.0 bits (99), Expect = 0.002
Identities = 27/85 (31%), Positives = 46/85 (54%), Gaps = 1/85 (1%)
Query: 5 TEWAQVEVVELTNDGNGLGFNLVGGRS-TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSV 63
+ + V+ +EL D GLG + + +GV+IK + GVA D RL+ GD +L V
Sbjct: 1476 SSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDE 1535
Query: 64 NLRGFTSEQVAAVLRQAGPVVRLLV 88
+ G+ E+ ++L+ A V+L +
Sbjct: 1536 IVVGYPIEKFISLLKTAKMTVKLTI 1560
Score = 43.6 bits (98), Expect = 0.002
Identities = 27/76 (35%), Positives = 38/76 (50%), Gaps = 3/76 (3%)
Query: 393 EGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHS 452
+GLG S+ G G P Y+++V G G L GD+++ VN L G+TH
Sbjct: 1995 DGLGFSIVGGYGSPHGD--LPI-YVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHE 2051
Query: 453 EVVNILKQLPDRVRLV 468
E V ILK+ V L+
Sbjct: 2052 EAVAILKRTKGTVTLM 2067
Score = 42.3 bits (95), Expect = 0.005
Identities = 29/97 (29%), Positives = 50/97 (51%), Gaps = 6/97 (6%)
Query: 529 EQSKKSRSLECVS-GLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVP 587
EQS + + ECV +S E + + K + LG ++ +D G ++VRS++
Sbjct: 984 EQSSLACNAECVMLQNVSKESFERTINIAKGNSSLGMTVSANKD-----GLGMIVRSIIH 1038
Query: 588 GGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
GG ++G I+ GD ++S+N S + T QA L+
Sbjct: 1039 GGAISRDGRIAIGDCILSINEESTISVTNAQARAMLR 1075
Score = 39.1 bits (87), Expect = 0.049
Identities = 21/70 (30%), Positives = 38/70 (54%)
Query: 208 LGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEI 267
LGI++AG V IF+ + A Q+ K+++ DRI+ + G S ++ Q+V +
Sbjct: 1873 LGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNL 1932
Query: 268 LRNTGISVHL 277
L+N S+ +
Sbjct: 1933 LKNASGSIEM 1942
Score = 38.7 bits (86), Expect = 0.064
Identities = 22/80 (27%), Positives = 43/80 (53%), Gaps = 4/80 (5%)
Query: 207 GLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVE 266
GLG+++ G K +G+FV I++G A+ G++ D+I+ V+G + + +
Sbjct: 1735 GLGLSIVG----KRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAA 1790
Query: 267 ILRNTGISVHLVLERYLRGP 286
+L+ + +V L + R GP
Sbjct: 1791 LLKCSLGTVTLEVGRIKAGP 1810
Score = 37.9 bits (84), Expect = 0.11
Identities = 27/91 (29%), Positives = 45/91 (49%), Gaps = 4/91 (4%)
Query: 394 GLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRL-HGLTHS 452
GLG S+ G G EL +++ + G L D++L +N L +TH
Sbjct: 147 GLGFSVVGLRSENRG-ELGI--FVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQ 203
Query: 453 EVVNILKQLPDRVRLVCARNSIDSGPRPVVN 483
+ ++IL++ D V+LV AR S+ P+V+
Sbjct: 204 QAISILQKAKDTVQLVIARGSLPQLVSPIVS 234
Score = 37.5 bits (83), Expect = 0.15
Identities = 31/137 (22%), Positives = 58/137 (42%), Gaps = 4/137 (2%)
Query: 199 VDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLAD 258
+++ K LG+TV+ K+ L G+ V+SII G + + G+I I D I+ ++ S
Sbjct: 1009 INIAKGNSSLGMTVSA---NKDGL-GMIVRSIIHGGAISRDGRIAIGDCILSINEESTIS 1064
Query: 259 KSNPQSVEILRNTGISVHLVLERYLRGPKFEHLQLAIFNEERXXXXXXXXXXLSWFPVPS 318
+N Q+ +LR + + Y+ E ++++ + + +P
Sbjct: 1065 VTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDIPE 1124
Query: 319 QLENSITEIEPEPESNT 335
E E E NT
Sbjct: 1125 LPEREEGEGEESELQNT 1141
Score = 35.9 bits (79), Expect = 0.45
Identities = 23/80 (28%), Positives = 35/80 (43%), Gaps = 3/80 (3%)
Query: 17 NDGNGLGFNLVGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAV 76
N G G+ G I+ VLP G +L SGD +L+V + L G + V +
Sbjct: 562 NSGLGISLEATVGHH---FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNI 618
Query: 77 LRQAGPVVRLLVARPADPAT 96
L++ V ++ R P T
Sbjct: 619 LKELPIEVTMVCCRRTVPPT 638
Score = 33.9 bits (74), Expect = 1.8
Identities = 23/97 (23%), Positives = 45/97 (46%), Gaps = 6/97 (6%)
Query: 3 LSTEWAQVEVVELTNDG-NGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDH 56
L++E + VE+ + LG ++ GG + + I + P GVA + ++L+ GD
Sbjct: 1853 LASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDR 1912
Query: 57 VLQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVARPAD 93
++ + + G T Q +L+ A + + V D
Sbjct: 1913 IVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGD 1949
>AL162386-1|CAH71900.1| 2042|Homo sapiens multiple PDZ domain
protein protein.
Length = 2042
Score = 293 bits (718), Expect = 2e-78
Identities = 201/479 (41%), Positives = 275/479 (57%), Gaps = 58/479 (12%)
Query: 178 SVSPTITITVPVELP-----EIEIIHVDLNKNVYGLGITVAGYVCEKE-ELSGIFVKSII 231
S SPT T + V+ E E V+L KNV GLGIT+AGY+ +K+ E SGIFVKSI
Sbjct: 352 SSSPTSTPELRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSIT 411
Query: 232 EGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHL 291
+ S+ E G+I+I D+II VDG +L +N Q+VE+LR+TG +V L L R RG K E
Sbjct: 412 KSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMR--RGMKQEA- 468
Query: 292 QLAIFNEERXXXXXXXXXXLSWFPVPSQLENSITEIEPEPESNTTIDSSVLEVGDLQEPT 351
E LS PV + + E + E ++T ++++L PT
Sbjct: 469 ------ELMSREDVTKDADLS--PVNASIIKENYE-KDEDFLSSTRNTNIL-------PT 512
Query: 352 QEE----LDQRFDEILAVDKED--IVKKWKEEIGSDKEILVAEIKKLE---GLGISLEGT 402
+EE L +EI K++ ++ KW+ +G + EI+VA + K GLGISLE T
Sbjct: 513 EEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEAT 572
Query: 403 VDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP 462
V HH+IRSVLP+GPVG G L +GDELLEVN L G H +VVNILK+LP
Sbjct: 573 VG---------HHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELP 623
Query: 463 DRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTSSTA 522
V +VC R ++ P D S L ++ K D S+
Sbjct: 624 IEVTMVCCRRTVP----PTTQSELD----------SLDLCDIELTEKPHVDLGEFIGSSE 669
Query: 523 TLTNHSEQSKKSRSLECVSG-LAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIV 581
T + +S E V LAMW++ + L K +GLGFSILDYQDP+DP TVI+
Sbjct: 670 TEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPASTVII 729
Query: 582 VRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPLP 640
+RSLVPGG+AEK+G + PGDR+M VN V+++N++L++AV+ALKGAP GTV++G+A+PLP
Sbjct: 730 IRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLP 788
Score = 114 bits (275), Expect = 8e-25
Identities = 49/86 (56%), Positives = 68/86 (79%)
Query: 7 WAQVEVVELTNDGNGLGFNLVGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLR 66
W +E +EL NDG+GLGF ++GG++TGV++K +LPGGVAD+ RL SGDH+L++G +L
Sbjct: 252 WQHMETIELVNDGSGLGFGIIGGKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLA 311
Query: 67 GFTSEQVAAVLRQAGPVVRLLVARPA 92
G +SEQVA VLRQ G V+L++AR A
Sbjct: 312 GMSSEQVAQVLRQCGNRVKLMIARGA 337
Score = 111 bits (267), Expect = 8e-24
Identities = 118/438 (26%), Positives = 197/438 (44%), Gaps = 55/438 (12%)
Query: 220 EELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
E + GIF+K ++E S A ++G +K DRI+EVDG+ L D S+ Q+VE +R G V ++
Sbjct: 1180 EVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMV 1239
Query: 280 ERYLRGPKFEHLQLAIFNEERXXXXXXXXXXLSWFPVPSQLENSITEIEPEPESNTTI-- 337
+ + P+ L + N + + S +E EPE ++
Sbjct: 1240 QSIINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADKAPSQSESEPEKAPLCSVPP 1299
Query: 338 --DSSVLEVGDLQEPTQEELDQRFDEILAVDKED-IVKKWK---EEIGS-DKEILVAEIK 390
S+ E+G + TQ + + VDKED WK E G+ E+ + E++
Sbjct: 1300 PPPSAFAEMG--SDHTQSSASKISQD---VDKEDEFGYSWKNIRERYGTLTGELHMIELE 1354
Query: 391 K-LEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K GLG+SL G D R +I + P+G G G L DELLE+N L+G
Sbjct: 1355 KGHSGLGLSLAGNKD-----RSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGR 1409
Query: 450 THSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVK 509
+H +I+K P +V+++ RN + VN + G + S S N L
Sbjct: 1410 SHQNASSIIKCAPSKVKIIFIRN------KDAVNQMAVCPGNAVEPLPSNSEN----LQN 1459
Query: 510 AQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDY 569
+++ ++ TS A K + LE L K GLG +I +
Sbjct: 1460 KETEPTVTTSDAAV---DLSSFKNVQHLE----------------LPKDQGGLGIAISE- 1499
Query: 570 QDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRG 629
+D + + ++++SL GVA +G + GD++++V+ + +++ + LK A +
Sbjct: 1500 EDTL----SGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTA-KM 1554
Query: 630 TVKVGIARPLPPQDSSKS 647
TVK+ I P + S
Sbjct: 1555 TVKLTIHAENPDSQAVPS 1572
Score = 68.9 bits (161), Expect = 5e-11
Identities = 72/272 (26%), Positives = 115/272 (42%), Gaps = 26/272 (9%)
Query: 13 VELTNDGNGLGFNLVGG------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLR 66
VELT + GLG + G +G+ +K + + D R+Q GD ++ V NL+
Sbjct: 378 VELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQ 437
Query: 67 GFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVPTKILADPELLDRHLIET 126
GFT++Q VLR G V L + R A + TK AD ++ +I+
Sbjct: 438 GFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDV----TKD-ADLSPVNASIIKE 492
Query: 127 GYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQKIPDHPIVCDSVSPTITIT 186
Y D + NI E +++A + I D QK + + I
Sbjct: 493 NYEKDEDFLSSTRNTNIL-PTEEEGYPLLSAEIEEIED-AQK--QEAALLTKWQRIMGIN 548
Query: 187 VPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKIND 246
EI + HV GLGI++ V F++S++ SGK+ D
Sbjct: 549 Y-----EIVVAHVSKFSENSGLGISLEATVGHH------FIRSVLPEGPVGHSGKLFSGD 597
Query: 247 RIIEVDGISLADKSNPQSVEILRNTGISVHLV 278
++EV+GI+L +++ V IL+ I V +V
Sbjct: 598 ELLEVNGITLLGENHQDVVNILKELPIEVTMV 629
Score = 66.9 bits (156), Expect = 2e-10
Identities = 74/285 (25%), Positives = 125/285 (43%), Gaps = 20/285 (7%)
Query: 13 VELTNDGNGLGFNLVGGRST---GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFT 69
+E++ GLG ++VGG T ++I V G A KD RL +GD +L+V ++LR T
Sbjct: 1630 IEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKAT 1689
Query: 70 SEQVAAVLRQAGPVVRLLVARP---------ADPATALRAPQPGTALVPTKI--LADPEL 118
++ VLRQ VRL + R D T +PG L + + D +
Sbjct: 1690 HDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGKRNDTGV 1749
Query: 119 LDRHLIETGYG-AVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQKIPDHPIVC- 176
+++ G A L Q +NG++ T AA+ + I
Sbjct: 1750 FVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKCSLGTVTLEVGRIKAG 1809
Query: 177 DSVSPTITITVPVEL--PEIEIIH-VDLNKN-VYGLGITVAGYVCEKEELSGIFVKSIIE 232
S S ++ + EI+ + V++ K LGI++AG V IF+ +
Sbjct: 1810 SSTSESLESSSKKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHP 1869
Query: 233 GSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHL 277
A Q+ K+++ DRI+ + G S ++ Q+V +L+N S+ +
Sbjct: 1870 TGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEM 1914
Score = 59.3 bits (137), Expect = 4e-08
Identities = 67/285 (23%), Positives = 120/285 (42%), Gaps = 29/285 (10%)
Query: 379 GSDKEILVAEI-KKLEGLGISLEGTVDVEGGQELRPHH-YIRSVLPDGPVGLQGVLNAGD 436
G + E E+ K ++GLGI++ G + G ++L P +++S+ V G + GD
Sbjct: 370 GEESETFDVELTKNVQGLGITIAGYI---GDKKLEPSGIFVKSITKSSAVEHDGRIQIGD 426
Query: 437 ELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGP----RPVVNLASDREGFE 492
+++ V+ L G T+ + V +L+ V L R + R V +D
Sbjct: 427 QIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVN 486
Query: 493 ARKIISGSLNNLTTLVKAQSDTSI---NTSSTATLTNHSEQSKKSRSLECVSGLAMWQ-- 547
A II + + + +T+I L+ E+ + ++ E L WQ
Sbjct: 487 A-SIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAAL-LTKWQRI 544
Query: 548 ---SKEDIVMLVKA---DQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGD 601
+ E +V V + GLG S+ + V + +RS++P G +G++ GD
Sbjct: 545 MGINYEIVVAHVSKFSENSGLGISL---EATVGHH----FIRSVLPEGPVGHSGKLFSGD 597
Query: 602 RVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPLPPQDSSK 646
++ VNG+++ V LK P V R +PP S+
Sbjct: 598 ELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSE 642
Score = 59.3 bits (137), Expect = 4e-08
Identities = 58/206 (28%), Positives = 95/206 (46%), Gaps = 23/206 (11%)
Query: 8 AQVEVVELTNDGNGLGFNL------VGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVG 61
A ++ +EL GLGF++ + ST ++I+ ++PGG+A+KD RL GD ++ V
Sbjct: 696 AGIQHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVN 755
Query: 62 SVNLRGFTSEQVAAVLRQA-GPVVRLLVAR--PADPATALRAPQPGTALVPTKI-----L 113
VNL + E+ L+ A VR+ VA+ P P + + + L P L
Sbjct: 756 DVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSPEEGYVSAKEDSFLYPPHSCEEAGL 815
Query: 114 ADPELL--DRHLIETGYGAVYDLSQCYSDYN-INGQNGETETSIVAAAVSVIGDN---PQ 167
AD L D L+ T + D S S Y+ N T+ SI++ S GD
Sbjct: 816 ADKPLFRADLALVGTNDADLVDESTFESPYSPENDSIYSTQASILSLHGSSCGDGLNYGS 875
Query: 168 KIPDHP---IVCDSVSPTITITVPVE 190
+P P ++ +S P + + + +E
Sbjct: 876 SLPSSPPKDVIENSCDPVLDLHMSLE 901
Score = 57.2 bits (132), Expect = 2e-07
Identities = 63/278 (22%), Positives = 119/278 (42%), Gaps = 26/278 (9%)
Query: 377 EIGSDKEILVAEIKKLEG-LGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAG 435
++ S K + E+ K +G LGI++ + G I+S+ G G L G
Sbjct: 1474 DLSSFKNVQHLELPKDQGGLGIAISEEDTLSGV-------IIKSLTEHGVAATDGRLKVG 1526
Query: 436 DELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARK 495
D++L V++ + G + +++LK V+L + DS P A+ E
Sbjct: 1527 DQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGE------ 1580
Query: 496 IISGSLNNLTTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVML 555
N+ +L+ QS + ++ N S S + + + E + +
Sbjct: 1581 ----KKNSSQSLMVPQS----GSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEI 1632
Query: 556 VKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNAT 615
K GLG SI+ D + I++ + G A K+G + GD+++ VNG+ ++ AT
Sbjct: 1633 SKGRTGLGLSIVGGSDTLLG---AIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKAT 1689
Query: 616 LDQAVQALKGAPRGTVKVGIARPLPPQDSSKSKGTINV 653
D+A+ L+ P+ V++ + R P + T+ +
Sbjct: 1690 HDEAINVLRQTPQ-RVRLTLYRDEAPYKEEEVCDTLTI 1726
Score = 54.0 bits (124), Expect = 2e-06
Identities = 32/91 (35%), Positives = 51/91 (56%), Gaps = 6/91 (6%)
Query: 557 KADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATL 616
K +GLG SI+ + N T + V +V GG+A+ +G + GD+++ VNG ++NAT
Sbjct: 1731 KPGKGLGLSIVGKR-----NDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNAT- 1784
Query: 617 DQAVQALKGAPRGTVKVGIARPLPPQDSSKS 647
+AV AL GTV + + R +S+S
Sbjct: 1785 QEAVAALLKCSLGTVTLEVGRIKAGSSTSES 1815
Score = 52.4 bits (120), Expect = 5e-06
Identities = 28/85 (32%), Positives = 46/85 (54%), Gaps = 5/85 (5%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDHVLQVGSV 63
Q + + L +GLGF++VGG + + +K V G A +D RL+ GD ++ V
Sbjct: 1956 QCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQ 2015
Query: 64 NLRGFTSEQVAAVLRQAGPVVRLLV 88
+L G T E+ A+L++ V L+V
Sbjct: 2016 SLEGVTHEEAVAILKRTKGTVTLMV 2040
Score = 52.0 bits (119), Expect = 6e-06
Identities = 43/170 (25%), Positives = 82/170 (48%), Gaps = 17/170 (10%)
Query: 463 DRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTSSTA 522
DR+ +C ++ VNL + G ++++G +++ + Q + + ++ S
Sbjct: 1883 DRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGG--DVSVVTGHQQEPASSSLSFT 1940
Query: 523 TLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTV-IV 581
LT+ S +C S + L + GLGFSI+ P+G + I
Sbjct: 1941 GLTSSSIFQDDLGPPQCKS-----------ITLERGPDGLGFSIVGGYG--SPHGDLPIY 1987
Query: 582 VRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTV 631
V+++ G A ++G + GD++++VNG S++ T ++AV LK +GTV
Sbjct: 1988 VKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILK-RTKGTV 2036
Score = 50.4 bits (115), Expect = 2e-05
Identities = 28/76 (36%), Positives = 45/76 (59%), Gaps = 1/76 (1%)
Query: 207 GLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADK-SNPQSV 265
GLG +V G E GIFV+ I EGS A + G++K D+I+ ++G +L ++ Q++
Sbjct: 147 GLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAI 206
Query: 266 EILRNTGISVHLVLER 281
IL+ +V LV+ R
Sbjct: 207 SILQKAKDTVQLVIAR 222
Score = 50.4 bits (115), Expect = 2e-05
Identities = 39/122 (31%), Positives = 61/122 (50%), Gaps = 12/122 (9%)
Query: 163 GDNPQKIPDHPIVCDSVSPTITITV---PVELPEIEIIHVDLNKNVYGLGITVAGYVCEK 219
G PQ + PIV S S TI+ PV +E I +L + GLG + G
Sbjct: 223 GSLPQLVS--PIVSRSPSAASTISAHSNPVHWQHMETI--ELVNDGSGLGFGIIG----- 273
Query: 220 EELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
+ +G+ VK+I+ G A+Q G++ D I+++ LA S+ Q ++LR G V L++
Sbjct: 274 GKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMI 333
Query: 280 ER 281
R
Sbjct: 334 AR 335
Score = 50.4 bits (115), Expect = 2e-05
Identities = 31/110 (28%), Positives = 53/110 (48%), Gaps = 8/110 (7%)
Query: 528 SEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVP 587
S + ++ S WQ E I LV GLGF I + T ++V++++P
Sbjct: 234 SRSPSAASTISAHSNPVHWQHMETIE-LVNDGSGLGFGI------IGGKATGVIVKTILP 286
Query: 588 GGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIAR 637
GGVA+++G + GD ++ + + + +Q Q L+ VK+ IAR
Sbjct: 287 GGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQC-GNRVKLMIAR 335
Score = 50.4 bits (115), Expect = 2e-05
Identities = 27/94 (28%), Positives = 52/94 (55%), Gaps = 1/94 (1%)
Query: 177 DSVSPTITITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSG-IFVKSIIEGSS 235
D+ T + P+ + E I H++L K GLG ++ Y + S I ++S++ G
Sbjct: 679 DAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGI 738
Query: 236 AEQSGKIKINDRIIEVDGISLADKSNPQSVEILR 269
AE+ G++ DR++ V+ ++L + S ++VE L+
Sbjct: 739 AEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALK 772
Score = 50.0 bits (114), Expect = 3e-05
Identities = 67/297 (22%), Positives = 129/297 (43%), Gaps = 29/297 (9%)
Query: 5 TEWAQVEVVELTND-GNGLGFNLVGGRSTG-----------VVIKYVLPGGVADKDRRLQ 52
+ W Q VEL + LG ++VGGR G + IK+VL A K+ L+
Sbjct: 1144 SNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLK 1203
Query: 53 SGDHVLQVGSVNLRGFTSEQVAAVLRQAG-PV---VRLLVARP--ADPATALRAPQPGTA 106
GD +++V ++LR + EQ +R+AG PV V+ ++ RP + + L P
Sbjct: 1204 PGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYN 1263
Query: 107 LVPTKILADPELLDRHLIETGYGAVYDLSQ-CYSDYNINGQNGETETSIVAAAVSVIGDN 165
T AD ++ + + + + C E + ++ S I +
Sbjct: 1264 FSSTNPFADSLQINADKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQD 1323
Query: 166 PQKIPDHPIVCDSVSPTI-TITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSG 224
K + ++ T+T + + E+E H L G+++AG ++ +S
Sbjct: 1324 VDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGL-------GLSLAGNK-DRSRMS- 1374
Query: 225 IFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
+F+ I +A + G+++I D ++E++G L +S+ + I++ V ++ R
Sbjct: 1375 VFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIR 1431
Score = 50.0 bits (114), Expect = 3e-05
Identities = 28/104 (26%), Positives = 54/104 (51%), Gaps = 4/104 (3%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTGVVIKYVL---PGGVADKDRRLQSGDHVLQVGSVNL 65
++ ++EL +GLG +L G + + +++ P G A KD RLQ D +L++ L
Sbjct: 1347 ELHMIELEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQIL 1406
Query: 66 RGFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVP 109
G + + +++++ A V+++ R D + A PG A+ P
Sbjct: 1407 YGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQM-AVCPGNAVEP 1449
Score = 50.0 bits (114), Expect = 3e-05
Identities = 29/101 (28%), Positives = 57/101 (56%), Gaps = 6/101 (5%)
Query: 181 PTITIT-VPVELPEIEII-HVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQ 238
PT+T + V+L + + H++L K+ GLGI ++ E++ LSG+ +KS+ E A
Sbjct: 1464 PTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAIS----EEDTLSGVIIKSLTEHGVAAT 1519
Query: 239 SGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
G++K+ D+I+ VD + + + +L+ ++V L +
Sbjct: 1520 DGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTI 1560
Score = 48.8 bits (111), Expect = 6e-05
Identities = 36/125 (28%), Positives = 58/125 (46%), Gaps = 5/125 (4%)
Query: 503 NLTTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDI-VMLVKADQG 561
N L+ A+ T+ TA S + L + + E V L K QG
Sbjct: 327 NRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQKGEESETFDVELTKNVQG 386
Query: 562 LGFSILDY--QDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQA 619
LG +I Y ++P+G I V+S+ E +G I GD++++V+G ++Q T QA
Sbjct: 387 LGITIAGYIGDKKLEPSG--IFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQA 444
Query: 620 VQALK 624
V+ L+
Sbjct: 445 VEVLR 449
Score = 47.6 bits (108), Expect = 1e-04
Identities = 30/106 (28%), Positives = 54/106 (50%), Gaps = 4/106 (3%)
Query: 178 SVSPTITITVPVELPEIEIIH--VDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSS 235
S +P I + P P I ++++K GLG+++ G L I + + E +
Sbjct: 1607 SSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGG--SDTLLGAIIIHEVYEEGA 1664
Query: 236 AEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
A + G++ D+I+EV+GI L ++ +++ +LR T V L L R
Sbjct: 1665 ACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYR 1710
Score = 47.2 bits (107), Expect = 2e-04
Identities = 20/64 (31%), Positives = 39/64 (60%)
Query: 417 IRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDS 476
++++LP G G L +GD +L++ + L G++ +V +L+Q +RV+L+ AR +I+
Sbjct: 281 VKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARGAIEE 340
Query: 477 GPRP 480
P
Sbjct: 341 RTAP 344
Score = 46.4 bits (105), Expect = 3e-04
Identities = 35/138 (25%), Positives = 69/138 (50%), Gaps = 3/138 (2%)
Query: 143 INGQNGETETSIVAAA-VSVIGDNPQKIPDHPIVCDSVSPTITITVPVELPEIEIIHVDL 201
+ +G E +VA VSV+ + Q+ + ++ + + P+ + I ++
Sbjct: 1905 LKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKSITLER 1964
Query: 202 NKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSN 261
+ G I V GY +L I+VK++ +A + G++K D+II V+G SL ++
Sbjct: 1965 GPDGLGFSI-VGGYGSPHGDLP-IYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTH 2022
Query: 262 PQSVEILRNTGISVHLVL 279
++V IL+ T +V L++
Sbjct: 2023 EEAVAILKRTKGTVTLMV 2040
Score = 46.0 bits (104), Expect = 4e-04
Identities = 31/107 (28%), Positives = 58/107 (54%), Gaps = 5/107 (4%)
Query: 538 ECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTV-IVVRSLVPGGVAEKNGE 596
+ + +A + E +L GLGFS++ + + G + I V+ + G VA ++G
Sbjct: 124 QLIKNMAQGRHVEVFELLKPPSGGLGFSVVGLRS--ENRGELGIFVQEIQEGSVAHRDGR 181
Query: 597 ISPGDRVMSVNGVSI-QNATLDQAVQALKGAPRGTVKVGIARPLPPQ 642
+ D+++++NG ++ Q T QA+ L+ A + TV++ IAR PQ
Sbjct: 182 LKETDQILAINGQALDQTITHQQAISILQKA-KDTVQLVIARGSLPQ 227
Score = 44.0 bits (99), Expect = 0.002
Identities = 27/85 (31%), Positives = 46/85 (54%), Gaps = 1/85 (1%)
Query: 5 TEWAQVEVVELTNDGNGLGFNLVGGRS-TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSV 63
+ + V+ +EL D GLG + + +GV+IK + GVA D RL+ GD +L V
Sbjct: 1476 SSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDE 1535
Query: 64 NLRGFTSEQVAAVLRQAGPVVRLLV 88
+ G+ E+ ++L+ A V+L +
Sbjct: 1536 IVVGYPIEKFISLLKTAKMTVKLTI 1560
Score = 43.6 bits (98), Expect = 0.002
Identities = 27/76 (35%), Positives = 38/76 (50%), Gaps = 3/76 (3%)
Query: 393 EGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHS 452
+GLG S+ G G P Y+++V G G L GD+++ VN L G+TH
Sbjct: 1967 DGLGFSIVGGYGSPHGD--LPI-YVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHE 2023
Query: 453 EVVNILKQLPDRVRLV 468
E V ILK+ V L+
Sbjct: 2024 EAVAILKRTKGTVTLM 2039
Score = 42.3 bits (95), Expect = 0.005
Identities = 29/97 (29%), Positives = 50/97 (51%), Gaps = 6/97 (6%)
Query: 529 EQSKKSRSLECVS-GLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVP 587
EQS + + ECV +S E + + K + LG ++ +D G ++VRS++
Sbjct: 984 EQSSLACNAECVMLQNVSKESFERTINIAKGNSSLGMTVSANKD-----GLGMIVRSIIH 1038
Query: 588 GGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
GG ++G I+ GD ++S+N S + T QA L+
Sbjct: 1039 GGAISRDGRIAIGDCILSINEESTISVTNAQARAMLR 1075
Score = 37.9 bits (84), Expect = 0.11
Identities = 27/91 (29%), Positives = 45/91 (49%), Gaps = 4/91 (4%)
Query: 394 GLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRL-HGLTHS 452
GLG S+ G G EL +++ + G L D++L +N L +TH
Sbjct: 147 GLGFSVVGLRSENRG-ELGI--FVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQ 203
Query: 453 EVVNILKQLPDRVRLVCARNSIDSGPRPVVN 483
+ ++IL++ D V+LV AR S+ P+V+
Sbjct: 204 QAISILQKAKDTVQLVIARGSLPQLVSPIVS 234
Score = 37.5 bits (83), Expect = 0.15
Identities = 31/137 (22%), Positives = 58/137 (42%), Gaps = 4/137 (2%)
Query: 199 VDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLAD 258
+++ K LG+TV+ K+ L G+ V+SII G + + G+I I D I+ ++ S
Sbjct: 1009 INIAKGNSSLGMTVSA---NKDGL-GMIVRSIIHGGAISRDGRIAIGDCILSINEESTIS 1064
Query: 259 KSNPQSVEILRNTGISVHLVLERYLRGPKFEHLQLAIFNEERXXXXXXXXXXLSWFPVPS 318
+N Q+ +LR + + Y+ E ++++ + + +P
Sbjct: 1065 VTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDIPE 1124
Query: 319 QLENSITEIEPEPESNT 335
E E E NT
Sbjct: 1125 LPEREEGEGEESELQNT 1141
Score = 36.7 bits (81), Expect = 0.26
Identities = 21/62 (33%), Positives = 36/62 (58%), Gaps = 2/62 (3%)
Query: 575 PNGTV-IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKV 633
P G V I + + P GVA + ++ GDR++++ G S + T QAV LK A G++++
Sbjct: 1856 PLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNA-SGSIEM 1914
Query: 634 GI 635
+
Sbjct: 1915 QV 1916
Score = 35.9 bits (79), Expect = 0.45
Identities = 23/80 (28%), Positives = 35/80 (43%), Gaps = 3/80 (3%)
Query: 17 NDGNGLGFNLVGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAV 76
N G G+ G I+ VLP G +L SGD +L+V + L G + V +
Sbjct: 562 NSGLGISLEATVGHH---FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNI 618
Query: 77 LRQAGPVVRLLVARPADPAT 96
L++ V ++ R P T
Sbjct: 619 LKELPIEVTMVCCRRTVPPT 638
Score = 35.9 bits (79), Expect = 0.45
Identities = 21/79 (26%), Positives = 42/79 (53%), Gaps = 4/79 (5%)
Query: 207 GLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVE 266
GLG+++ G K +G+FV I++G A+ G++ D+I+ V+G + + +
Sbjct: 1735 GLGLSIVG----KRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAA 1790
Query: 267 ILRNTGISVHLVLERYLRG 285
+L+ + +V L + R G
Sbjct: 1791 LLKCSLGTVTLEVGRIKAG 1809
Score = 33.9 bits (74), Expect = 1.8
Identities = 23/97 (23%), Positives = 45/97 (46%), Gaps = 6/97 (6%)
Query: 3 LSTEWAQVEVVELTNDG-NGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDH 56
L++E + VE+ + LG ++ GG + + I + P GVA + ++L+ GD
Sbjct: 1825 LASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDR 1884
Query: 57 VLQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVARPAD 93
++ + + G T Q +L+ A + + V D
Sbjct: 1885 IVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGD 1921
Score = 32.7 bits (71), Expect = 4.2
Identities = 23/82 (28%), Positives = 37/82 (45%), Gaps = 5/82 (6%)
Query: 388 EIKK--LEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYR 445
E+KK + LGIS+ G V G +I + P G L GD ++ +
Sbjct: 1836 EMKKGPTDSLGISIAGGVGSPLGDV---PIFIAMMHPTGVAAQTQKLRVGDRIVTICGTS 1892
Query: 446 LHGLTHSEVVNILKQLPDRVRL 467
G+TH++ VN+LK + +
Sbjct: 1893 TEGMTHTQAVNLLKNASGSIEM 1914
>AL161449-5|CAI40492.1| 2042|Homo sapiens multiple PDZ domain
protein protein.
Length = 2042
Score = 293 bits (718), Expect = 2e-78
Identities = 201/479 (41%), Positives = 275/479 (57%), Gaps = 58/479 (12%)
Query: 178 SVSPTITITVPVELP-----EIEIIHVDLNKNVYGLGITVAGYVCEKE-ELSGIFVKSII 231
S SPT T + V+ E E V+L KNV GLGIT+AGY+ +K+ E SGIFVKSI
Sbjct: 352 SSSPTSTPELRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSIT 411
Query: 232 EGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHL 291
+ S+ E G+I+I D+II VDG +L +N Q+VE+LR+TG +V L L R RG K E
Sbjct: 412 KSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMR--RGMKQEA- 468
Query: 292 QLAIFNEERXXXXXXXXXXLSWFPVPSQLENSITEIEPEPESNTTIDSSVLEVGDLQEPT 351
E LS PV + + E + E ++T ++++L PT
Sbjct: 469 ------ELMSREDVTKDADLS--PVNASIIKENYE-KDEDFLSSTRNTNIL-------PT 512
Query: 352 QEE----LDQRFDEILAVDKED--IVKKWKEEIGSDKEILVAEIKKLE---GLGISLEGT 402
+EE L +EI K++ ++ KW+ +G + EI+VA + K GLGISLE T
Sbjct: 513 EEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEAT 572
Query: 403 VDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP 462
V HH+IRSVLP+GPVG G L +GDELLEVN L G H +VVNILK+LP
Sbjct: 573 VG---------HHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELP 623
Query: 463 DRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTSSTA 522
V +VC R ++ P D S L ++ K D S+
Sbjct: 624 IEVTMVCCRRTVP----PTTQSELD----------SLDLCDIELTEKPHVDLGEFIGSSE 669
Query: 523 TLTNHSEQSKKSRSLECVSG-LAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIV 581
T + +S E V LAMW++ + L K +GLGFSILDYQDP+DP TVI+
Sbjct: 670 TEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPASTVII 729
Query: 582 VRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPLP 640
+RSLVPGG+AEK+G + PGDR+M VN V+++N++L++AV+ALKGAP GTV++G+A+PLP
Sbjct: 730 IRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLP 788
Score = 114 bits (275), Expect = 8e-25
Identities = 49/86 (56%), Positives = 68/86 (79%)
Query: 7 WAQVEVVELTNDGNGLGFNLVGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLR 66
W +E +EL NDG+GLGF ++GG++TGV++K +LPGGVAD+ RL SGDH+L++G +L
Sbjct: 252 WQHMETIELVNDGSGLGFGIIGGKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLA 311
Query: 67 GFTSEQVAAVLRQAGPVVRLLVARPA 92
G +SEQVA VLRQ G V+L++AR A
Sbjct: 312 GMSSEQVAQVLRQCGNRVKLMIARGA 337
Score = 111 bits (267), Expect = 8e-24
Identities = 118/438 (26%), Positives = 197/438 (44%), Gaps = 55/438 (12%)
Query: 220 EELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
E + GIF+K ++E S A ++G +K DRI+EVDG+ L D S+ Q+VE +R G V ++
Sbjct: 1180 EVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMV 1239
Query: 280 ERYLRGPKFEHLQLAIFNEERXXXXXXXXXXLSWFPVPSQLENSITEIEPEPESNTTI-- 337
+ + P+ L + N + + S +E EPE ++
Sbjct: 1240 QSIINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADKAPSQSESEPEKAPLCSVPP 1299
Query: 338 --DSSVLEVGDLQEPTQEELDQRFDEILAVDKED-IVKKWK---EEIGS-DKEILVAEIK 390
S+ E+G + TQ + + VDKED WK E G+ E+ + E++
Sbjct: 1300 PPPSAFAEMG--SDHTQSSASKISQD---VDKEDEFGYSWKNIRERYGTLTGELHMIELE 1354
Query: 391 K-LEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K GLG+SL G D R +I + P+G G G L DELLE+N L+G
Sbjct: 1355 KGHSGLGLSLAGNKD-----RSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGR 1409
Query: 450 THSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVK 509
+H +I+K P +V+++ RN + VN + G + S S N L
Sbjct: 1410 SHQNASSIIKCAPSKVKIIFIRN------KDAVNQMAVCPGNAVEPLPSNSEN----LQN 1459
Query: 510 AQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDY 569
+++ ++ TS A K + LE L K GLG +I +
Sbjct: 1460 KETEPTVTTSDAAV---DLSSFKNVQHLE----------------LPKDQGGLGIAISE- 1499
Query: 570 QDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRG 629
+D + + ++++SL GVA +G + GD++++V+ + +++ + LK A +
Sbjct: 1500 EDTL----SGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTA-KM 1554
Query: 630 TVKVGIARPLPPQDSSKS 647
TVK+ I P + S
Sbjct: 1555 TVKLTIHAENPDSQAVPS 1572
Score = 68.9 bits (161), Expect = 5e-11
Identities = 72/272 (26%), Positives = 115/272 (42%), Gaps = 26/272 (9%)
Query: 13 VELTNDGNGLGFNLVGG------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLR 66
VELT + GLG + G +G+ +K + + D R+Q GD ++ V NL+
Sbjct: 378 VELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQ 437
Query: 67 GFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVPTKILADPELLDRHLIET 126
GFT++Q VLR G V L + R A + TK AD ++ +I+
Sbjct: 438 GFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDV----TKD-ADLSPVNASIIKE 492
Query: 127 GYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQKIPDHPIVCDSVSPTITIT 186
Y D + NI E +++A + I D QK + + I
Sbjct: 493 NYEKDEDFLSSTRNTNIL-PTEEEGYPLLSAEIEEIED-AQK--QEAALLTKWQRIMGIN 548
Query: 187 VPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKIND 246
EI + HV GLGI++ V F++S++ SGK+ D
Sbjct: 549 Y-----EIVVAHVSKFSENSGLGISLEATVGHH------FIRSVLPEGPVGHSGKLFSGD 597
Query: 247 RIIEVDGISLADKSNPQSVEILRNTGISVHLV 278
++EV+GI+L +++ V IL+ I V +V
Sbjct: 598 ELLEVNGITLLGENHQDVVNILKELPIEVTMV 629
Score = 66.9 bits (156), Expect = 2e-10
Identities = 74/285 (25%), Positives = 125/285 (43%), Gaps = 20/285 (7%)
Query: 13 VELTNDGNGLGFNLVGGRST---GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFT 69
+E++ GLG ++VGG T ++I V G A KD RL +GD +L+V ++LR T
Sbjct: 1630 IEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKAT 1689
Query: 70 SEQVAAVLRQAGPVVRLLVARP---------ADPATALRAPQPGTALVPTKI--LADPEL 118
++ VLRQ VRL + R D T +PG L + + D +
Sbjct: 1690 HDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGKRNDTGV 1749
Query: 119 LDRHLIETGYG-AVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQKIPDHPIVC- 176
+++ G A L Q +NG++ T AA+ + I
Sbjct: 1750 FVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKCSLGTVTLEVGRIKAG 1809
Query: 177 DSVSPTITITVPVEL--PEIEIIH-VDLNKN-VYGLGITVAGYVCEKEELSGIFVKSIIE 232
S S ++ + EI+ + V++ K LGI++AG V IF+ +
Sbjct: 1810 SSTSESLESSSKKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHP 1869
Query: 233 GSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHL 277
A Q+ K+++ DRI+ + G S ++ Q+V +L+N S+ +
Sbjct: 1870 TGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEM 1914
Score = 59.3 bits (137), Expect = 4e-08
Identities = 67/285 (23%), Positives = 120/285 (42%), Gaps = 29/285 (10%)
Query: 379 GSDKEILVAEI-KKLEGLGISLEGTVDVEGGQELRPHH-YIRSVLPDGPVGLQGVLNAGD 436
G + E E+ K ++GLGI++ G + G ++L P +++S+ V G + GD
Sbjct: 370 GEESETFDVELTKNVQGLGITIAGYI---GDKKLEPSGIFVKSITKSSAVEHDGRIQIGD 426
Query: 437 ELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGP----RPVVNLASDREGFE 492
+++ V+ L G T+ + V +L+ V L R + R V +D
Sbjct: 427 QIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVN 486
Query: 493 ARKIISGSLNNLTTLVKAQSDTSI---NTSSTATLTNHSEQSKKSRSLECVSGLAMWQ-- 547
A II + + + +T+I L+ E+ + ++ E L WQ
Sbjct: 487 A-SIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAAL-LTKWQRI 544
Query: 548 ---SKEDIVMLVKA---DQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGD 601
+ E +V V + GLG S+ + V + +RS++P G +G++ GD
Sbjct: 545 MGINYEIVVAHVSKFSENSGLGISL---EATVGHH----FIRSVLPEGPVGHSGKLFSGD 597
Query: 602 RVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPLPPQDSSK 646
++ VNG+++ V LK P V R +PP S+
Sbjct: 598 ELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSE 642
Score = 59.3 bits (137), Expect = 4e-08
Identities = 58/206 (28%), Positives = 95/206 (46%), Gaps = 23/206 (11%)
Query: 8 AQVEVVELTNDGNGLGFNL------VGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVG 61
A ++ +EL GLGF++ + ST ++I+ ++PGG+A+KD RL GD ++ V
Sbjct: 696 AGIQHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVN 755
Query: 62 SVNLRGFTSEQVAAVLRQA-GPVVRLLVAR--PADPATALRAPQPGTALVPTKI-----L 113
VNL + E+ L+ A VR+ VA+ P P + + + L P L
Sbjct: 756 DVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSPEEGYVSAKEDSFLYPPHSCEEAGL 815
Query: 114 ADPELL--DRHLIETGYGAVYDLSQCYSDYN-INGQNGETETSIVAAAVSVIGDN---PQ 167
AD L D L+ T + D S S Y+ N T+ SI++ S GD
Sbjct: 816 ADKPLFRADLALVGTNDADLVDESTFESPYSPENDSIYSTQASILSLHGSSCGDGLNYGS 875
Query: 168 KIPDHP---IVCDSVSPTITITVPVE 190
+P P ++ +S P + + + +E
Sbjct: 876 SLPSSPPKDVIENSCDPVLDLHMSLE 901
Score = 57.2 bits (132), Expect = 2e-07
Identities = 63/278 (22%), Positives = 119/278 (42%), Gaps = 26/278 (9%)
Query: 377 EIGSDKEILVAEIKKLEG-LGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAG 435
++ S K + E+ K +G LGI++ + G I+S+ G G L G
Sbjct: 1474 DLSSFKNVQHLELPKDQGGLGIAISEEDTLSGV-------IIKSLTEHGVAATDGRLKVG 1526
Query: 436 DELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARK 495
D++L V++ + G + +++LK V+L + DS P A+ E
Sbjct: 1527 DQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGE------ 1580
Query: 496 IISGSLNNLTTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVML 555
N+ +L+ QS + ++ N S S + + + E + +
Sbjct: 1581 ----KKNSSQSLMVPQS----GSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEI 1632
Query: 556 VKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNAT 615
K GLG SI+ D + I++ + G A K+G + GD+++ VNG+ ++ AT
Sbjct: 1633 SKGRTGLGLSIVGGSDTLLG---AIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKAT 1689
Query: 616 LDQAVQALKGAPRGTVKVGIARPLPPQDSSKSKGTINV 653
D+A+ L+ P+ V++ + R P + T+ +
Sbjct: 1690 HDEAINVLRQTPQ-RVRLTLYRDEAPYKEEEVCDTLTI 1726
Score = 54.0 bits (124), Expect = 2e-06
Identities = 32/91 (35%), Positives = 51/91 (56%), Gaps = 6/91 (6%)
Query: 557 KADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATL 616
K +GLG SI+ + N T + V +V GG+A+ +G + GD+++ VNG ++NAT
Sbjct: 1731 KPGKGLGLSIVGKR-----NDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNAT- 1784
Query: 617 DQAVQALKGAPRGTVKVGIARPLPPQDSSKS 647
+AV AL GTV + + R +S+S
Sbjct: 1785 QEAVAALLKCSLGTVTLEVGRIKAGSSTSES 1815
Score = 52.4 bits (120), Expect = 5e-06
Identities = 28/85 (32%), Positives = 46/85 (54%), Gaps = 5/85 (5%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDHVLQVGSV 63
Q + + L +GLGF++VGG + + +K V G A +D RL+ GD ++ V
Sbjct: 1956 QCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQ 2015
Query: 64 NLRGFTSEQVAAVLRQAGPVVRLLV 88
+L G T E+ A+L++ V L+V
Sbjct: 2016 SLEGVTHEEAVAILKRTKGTVTLMV 2040
Score = 52.0 bits (119), Expect = 6e-06
Identities = 43/170 (25%), Positives = 82/170 (48%), Gaps = 17/170 (10%)
Query: 463 DRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTSSTA 522
DR+ +C ++ VNL + G ++++G +++ + Q + + ++ S
Sbjct: 1883 DRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGG--DVSVVTGHQQEPASSSLSFT 1940
Query: 523 TLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTV-IV 581
LT+ S +C S + L + GLGFSI+ P+G + I
Sbjct: 1941 GLTSSSIFQDDLGPPQCKS-----------ITLERGPDGLGFSIVGGYG--SPHGDLPIY 1987
Query: 582 VRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTV 631
V+++ G A ++G + GD++++VNG S++ T ++AV LK +GTV
Sbjct: 1988 VKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILK-RTKGTV 2036
Score = 50.4 bits (115), Expect = 2e-05
Identities = 28/76 (36%), Positives = 45/76 (59%), Gaps = 1/76 (1%)
Query: 207 GLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADK-SNPQSV 265
GLG +V G E GIFV+ I EGS A + G++K D+I+ ++G +L ++ Q++
Sbjct: 147 GLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAI 206
Query: 266 EILRNTGISVHLVLER 281
IL+ +V LV+ R
Sbjct: 207 SILQKAKDTVQLVIAR 222
Score = 50.4 bits (115), Expect = 2e-05
Identities = 39/122 (31%), Positives = 61/122 (50%), Gaps = 12/122 (9%)
Query: 163 GDNPQKIPDHPIVCDSVSPTITITV---PVELPEIEIIHVDLNKNVYGLGITVAGYVCEK 219
G PQ + PIV S S TI+ PV +E I +L + GLG + G
Sbjct: 223 GSLPQLVS--PIVSRSPSAASTISAHSNPVHWQHMETI--ELVNDGSGLGFGIIG----- 273
Query: 220 EELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
+ +G+ VK+I+ G A+Q G++ D I+++ LA S+ Q ++LR G V L++
Sbjct: 274 GKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMI 333
Query: 280 ER 281
R
Sbjct: 334 AR 335
Score = 50.4 bits (115), Expect = 2e-05
Identities = 31/110 (28%), Positives = 53/110 (48%), Gaps = 8/110 (7%)
Query: 528 SEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVP 587
S + ++ S WQ E I LV GLGF I + T ++V++++P
Sbjct: 234 SRSPSAASTISAHSNPVHWQHMETIE-LVNDGSGLGFGI------IGGKATGVIVKTILP 286
Query: 588 GGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIAR 637
GGVA+++G + GD ++ + + + +Q Q L+ VK+ IAR
Sbjct: 287 GGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQC-GNRVKLMIAR 335
Score = 50.4 bits (115), Expect = 2e-05
Identities = 27/94 (28%), Positives = 52/94 (55%), Gaps = 1/94 (1%)
Query: 177 DSVSPTITITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSG-IFVKSIIEGSS 235
D+ T + P+ + E I H++L K GLG ++ Y + S I ++S++ G
Sbjct: 679 DAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGI 738
Query: 236 AEQSGKIKINDRIIEVDGISLADKSNPQSVEILR 269
AE+ G++ DR++ V+ ++L + S ++VE L+
Sbjct: 739 AEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALK 772
Score = 50.0 bits (114), Expect = 3e-05
Identities = 67/297 (22%), Positives = 129/297 (43%), Gaps = 29/297 (9%)
Query: 5 TEWAQVEVVELTND-GNGLGFNLVGGRSTG-----------VVIKYVLPGGVADKDRRLQ 52
+ W Q VEL + LG ++VGGR G + IK+VL A K+ L+
Sbjct: 1144 SNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLK 1203
Query: 53 SGDHVLQVGSVNLRGFTSEQVAAVLRQAG-PV---VRLLVARP--ADPATALRAPQPGTA 106
GD +++V ++LR + EQ +R+AG PV V+ ++ RP + + L P
Sbjct: 1204 PGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYN 1263
Query: 107 LVPTKILADPELLDRHLIETGYGAVYDLSQ-CYSDYNINGQNGETETSIVAAAVSVIGDN 165
T AD ++ + + + + C E + ++ S I +
Sbjct: 1264 FSSTNPFADSLQINADKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQD 1323
Query: 166 PQKIPDHPIVCDSVSPTI-TITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSG 224
K + ++ T+T + + E+E H L G+++AG ++ +S
Sbjct: 1324 VDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGL-------GLSLAGNK-DRSRMS- 1374
Query: 225 IFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
+F+ I +A + G+++I D ++E++G L +S+ + I++ V ++ R
Sbjct: 1375 VFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIR 1431
Score = 50.0 bits (114), Expect = 3e-05
Identities = 28/104 (26%), Positives = 54/104 (51%), Gaps = 4/104 (3%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTGVVIKYVL---PGGVADKDRRLQSGDHVLQVGSVNL 65
++ ++EL +GLG +L G + + +++ P G A KD RLQ D +L++ L
Sbjct: 1347 ELHMIELEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQIL 1406
Query: 66 RGFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVP 109
G + + +++++ A V+++ R D + A PG A+ P
Sbjct: 1407 YGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQM-AVCPGNAVEP 1449
Score = 50.0 bits (114), Expect = 3e-05
Identities = 29/101 (28%), Positives = 57/101 (56%), Gaps = 6/101 (5%)
Query: 181 PTITIT-VPVELPEIEII-HVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQ 238
PT+T + V+L + + H++L K+ GLGI ++ E++ LSG+ +KS+ E A
Sbjct: 1464 PTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAIS----EEDTLSGVIIKSLTEHGVAAT 1519
Query: 239 SGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
G++K+ D+I+ VD + + + +L+ ++V L +
Sbjct: 1520 DGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTI 1560
Score = 48.8 bits (111), Expect = 6e-05
Identities = 36/125 (28%), Positives = 58/125 (46%), Gaps = 5/125 (4%)
Query: 503 NLTTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDI-VMLVKADQG 561
N L+ A+ T+ TA S + L + + E V L K QG
Sbjct: 327 NRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQKGEESETFDVELTKNVQG 386
Query: 562 LGFSILDY--QDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQA 619
LG +I Y ++P+G I V+S+ E +G I GD++++V+G ++Q T QA
Sbjct: 387 LGITIAGYIGDKKLEPSG--IFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQA 444
Query: 620 VQALK 624
V+ L+
Sbjct: 445 VEVLR 449
Score = 47.6 bits (108), Expect = 1e-04
Identities = 30/106 (28%), Positives = 54/106 (50%), Gaps = 4/106 (3%)
Query: 178 SVSPTITITVPVELPEIEIIH--VDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSS 235
S +P I + P P I ++++K GLG+++ G L I + + E +
Sbjct: 1607 SSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGG--SDTLLGAIIIHEVYEEGA 1664
Query: 236 AEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
A + G++ D+I+EV+GI L ++ +++ +LR T V L L R
Sbjct: 1665 ACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYR 1710
Score = 47.2 bits (107), Expect = 2e-04
Identities = 20/64 (31%), Positives = 39/64 (60%)
Query: 417 IRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDS 476
++++LP G G L +GD +L++ + L G++ +V +L+Q +RV+L+ AR +I+
Sbjct: 281 VKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARGAIEE 340
Query: 477 GPRP 480
P
Sbjct: 341 RTAP 344
Score = 46.4 bits (105), Expect = 3e-04
Identities = 35/138 (25%), Positives = 69/138 (50%), Gaps = 3/138 (2%)
Query: 143 INGQNGETETSIVAAA-VSVIGDNPQKIPDHPIVCDSVSPTITITVPVELPEIEIIHVDL 201
+ +G E +VA VSV+ + Q+ + ++ + + P+ + I ++
Sbjct: 1905 LKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKSITLER 1964
Query: 202 NKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSN 261
+ G I V GY +L I+VK++ +A + G++K D+II V+G SL ++
Sbjct: 1965 GPDGLGFSI-VGGYGSPHGDLP-IYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTH 2022
Query: 262 PQSVEILRNTGISVHLVL 279
++V IL+ T +V L++
Sbjct: 2023 EEAVAILKRTKGTVTLMV 2040
Score = 46.0 bits (104), Expect = 4e-04
Identities = 31/107 (28%), Positives = 58/107 (54%), Gaps = 5/107 (4%)
Query: 538 ECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTV-IVVRSLVPGGVAEKNGE 596
+ + +A + E +L GLGFS++ + + G + I V+ + G VA ++G
Sbjct: 124 QLIKNMAQGRHVEVFELLKPPSGGLGFSVVGLRS--ENRGELGIFVQEIQEGSVAHRDGR 181
Query: 597 ISPGDRVMSVNGVSI-QNATLDQAVQALKGAPRGTVKVGIARPLPPQ 642
+ D+++++NG ++ Q T QA+ L+ A + TV++ IAR PQ
Sbjct: 182 LKETDQILAINGQALDQTITHQQAISILQKA-KDTVQLVIARGSLPQ 227
Score = 44.0 bits (99), Expect = 0.002
Identities = 27/85 (31%), Positives = 46/85 (54%), Gaps = 1/85 (1%)
Query: 5 TEWAQVEVVELTNDGNGLGFNLVGGRS-TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSV 63
+ + V+ +EL D GLG + + +GV+IK + GVA D RL+ GD +L V
Sbjct: 1476 SSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDE 1535
Query: 64 NLRGFTSEQVAAVLRQAGPVVRLLV 88
+ G+ E+ ++L+ A V+L +
Sbjct: 1536 IVVGYPIEKFISLLKTAKMTVKLTI 1560
Score = 43.6 bits (98), Expect = 0.002
Identities = 27/76 (35%), Positives = 38/76 (50%), Gaps = 3/76 (3%)
Query: 393 EGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHS 452
+GLG S+ G G P Y+++V G G L GD+++ VN L G+TH
Sbjct: 1967 DGLGFSIVGGYGSPHGD--LPI-YVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHE 2023
Query: 453 EVVNILKQLPDRVRLV 468
E V ILK+ V L+
Sbjct: 2024 EAVAILKRTKGTVTLM 2039
Score = 42.3 bits (95), Expect = 0.005
Identities = 29/97 (29%), Positives = 50/97 (51%), Gaps = 6/97 (6%)
Query: 529 EQSKKSRSLECVS-GLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVP 587
EQS + + ECV +S E + + K + LG ++ +D G ++VRS++
Sbjct: 984 EQSSLACNAECVMLQNVSKESFERTINIAKGNSSLGMTVSANKD-----GLGMIVRSIIH 1038
Query: 588 GGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
GG ++G I+ GD ++S+N S + T QA L+
Sbjct: 1039 GGAISRDGRIAIGDCILSINEESTISVTNAQARAMLR 1075
Score = 37.9 bits (84), Expect = 0.11
Identities = 27/91 (29%), Positives = 45/91 (49%), Gaps = 4/91 (4%)
Query: 394 GLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRL-HGLTHS 452
GLG S+ G G EL +++ + G L D++L +N L +TH
Sbjct: 147 GLGFSVVGLRSENRG-ELGI--FVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQ 203
Query: 453 EVVNILKQLPDRVRLVCARNSIDSGPRPVVN 483
+ ++IL++ D V+LV AR S+ P+V+
Sbjct: 204 QAISILQKAKDTVQLVIARGSLPQLVSPIVS 234
Score = 37.5 bits (83), Expect = 0.15
Identities = 31/137 (22%), Positives = 58/137 (42%), Gaps = 4/137 (2%)
Query: 199 VDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLAD 258
+++ K LG+TV+ K+ L G+ V+SII G + + G+I I D I+ ++ S
Sbjct: 1009 INIAKGNSSLGMTVSA---NKDGL-GMIVRSIIHGGAISRDGRIAIGDCILSINEESTIS 1064
Query: 259 KSNPQSVEILRNTGISVHLVLERYLRGPKFEHLQLAIFNEERXXXXXXXXXXLSWFPVPS 318
+N Q+ +LR + + Y+ E ++++ + + +P
Sbjct: 1065 VTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDIPE 1124
Query: 319 QLENSITEIEPEPESNT 335
E E E NT
Sbjct: 1125 LPEREEGEGEESELQNT 1141
Score = 36.7 bits (81), Expect = 0.26
Identities = 21/62 (33%), Positives = 36/62 (58%), Gaps = 2/62 (3%)
Query: 575 PNGTV-IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKV 633
P G V I + + P GVA + ++ GDR++++ G S + T QAV LK A G++++
Sbjct: 1856 PLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNA-SGSIEM 1914
Query: 634 GI 635
+
Sbjct: 1915 QV 1916
Score = 35.9 bits (79), Expect = 0.45
Identities = 23/80 (28%), Positives = 35/80 (43%), Gaps = 3/80 (3%)
Query: 17 NDGNGLGFNLVGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAV 76
N G G+ G I+ VLP G +L SGD +L+V + L G + V +
Sbjct: 562 NSGLGISLEATVGHH---FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNI 618
Query: 77 LRQAGPVVRLLVARPADPAT 96
L++ V ++ R P T
Sbjct: 619 LKELPIEVTMVCCRRTVPPT 638
Score = 35.9 bits (79), Expect = 0.45
Identities = 21/79 (26%), Positives = 42/79 (53%), Gaps = 4/79 (5%)
Query: 207 GLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVE 266
GLG+++ G K +G+FV I++G A+ G++ D+I+ V+G + + +
Sbjct: 1735 GLGLSIVG----KRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAA 1790
Query: 267 ILRNTGISVHLVLERYLRG 285
+L+ + +V L + R G
Sbjct: 1791 LLKCSLGTVTLEVGRIKAG 1809
Score = 33.9 bits (74), Expect = 1.8
Identities = 23/97 (23%), Positives = 45/97 (46%), Gaps = 6/97 (6%)
Query: 3 LSTEWAQVEVVELTNDG-NGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDH 56
L++E + VE+ + LG ++ GG + + I + P GVA + ++L+ GD
Sbjct: 1825 LASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDR 1884
Query: 57 VLQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVARPAD 93
++ + + G T Q +L+ A + + V D
Sbjct: 1885 IVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGD 1921
Score = 32.7 bits (71), Expect = 4.2
Identities = 23/82 (28%), Positives = 37/82 (45%), Gaps = 5/82 (6%)
Query: 388 EIKK--LEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYR 445
E+KK + LGIS+ G V G +I + P G L GD ++ +
Sbjct: 1836 EMKKGPTDSLGISIAGGVGSPLGDV---PIFIAMMHPTGVAAQTQKLRVGDRIVTICGTS 1892
Query: 446 LHGLTHSEVVNILKQLPDRVRL 467
G+TH++ VN+LK + +
Sbjct: 1893 TEGMTHTQAVNLLKNASGSIEM 1914
>AL161449-4|CAI40493.1| 2070|Homo sapiens multiple PDZ domain
protein protein.
Length = 2070
Score = 293 bits (718), Expect = 2e-78
Identities = 201/479 (41%), Positives = 275/479 (57%), Gaps = 58/479 (12%)
Query: 178 SVSPTITITVPVELP-----EIEIIHVDLNKNVYGLGITVAGYVCEKE-ELSGIFVKSII 231
S SPT T + V+ E E V+L KNV GLGIT+AGY+ +K+ E SGIFVKSI
Sbjct: 352 SSSPTSTPELRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSIT 411
Query: 232 EGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHL 291
+ S+ E G+I+I D+II VDG +L +N Q+VE+LR+TG +V L L R RG K E
Sbjct: 412 KSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMR--RGMKQEA- 468
Query: 292 QLAIFNEERXXXXXXXXXXLSWFPVPSQLENSITEIEPEPESNTTIDSSVLEVGDLQEPT 351
E LS PV + + E + E ++T ++++L PT
Sbjct: 469 ------ELMSREDVTKDADLS--PVNASIIKENYE-KDEDFLSSTRNTNIL-------PT 512
Query: 352 QEE----LDQRFDEILAVDKED--IVKKWKEEIGSDKEILVAEIKKLE---GLGISLEGT 402
+EE L +EI K++ ++ KW+ +G + EI+VA + K GLGISLE T
Sbjct: 513 EEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEAT 572
Query: 403 VDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP 462
V HH+IRSVLP+GPVG G L +GDELLEVN L G H +VVNILK+LP
Sbjct: 573 VG---------HHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELP 623
Query: 463 DRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTSSTA 522
V +VC R ++ P D S L ++ K D S+
Sbjct: 624 IEVTMVCCRRTVP----PTTQSELD----------SLDLCDIELTEKPHVDLGEFIGSSE 669
Query: 523 TLTNHSEQSKKSRSLECVSG-LAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIV 581
T + +S E V LAMW++ + L K +GLGFSILDYQDP+DP TVI+
Sbjct: 670 TEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPASTVII 729
Query: 582 VRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPLP 640
+RSLVPGG+AEK+G + PGDR+M VN V+++N++L++AV+ALKGAP GTV++G+A+PLP
Sbjct: 730 IRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLP 788
Score = 114 bits (275), Expect = 8e-25
Identities = 49/86 (56%), Positives = 68/86 (79%)
Query: 7 WAQVEVVELTNDGNGLGFNLVGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLR 66
W +E +EL NDG+GLGF ++GG++TGV++K +LPGGVAD+ RL SGDH+L++G +L
Sbjct: 252 WQHMETIELVNDGSGLGFGIIGGKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLA 311
Query: 67 GFTSEQVAAVLRQAGPVVRLLVARPA 92
G +SEQVA VLRQ G V+L++AR A
Sbjct: 312 GMSSEQVAQVLRQCGNRVKLMIARGA 337
Score = 111 bits (267), Expect = 8e-24
Identities = 118/438 (26%), Positives = 197/438 (44%), Gaps = 55/438 (12%)
Query: 220 EELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
E + GIF+K ++E S A ++G +K DRI+EVDG+ L D S+ Q+VE +R G V ++
Sbjct: 1180 EVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMV 1239
Query: 280 ERYLRGPKFEHLQLAIFNEERXXXXXXXXXXLSWFPVPSQLENSITEIEPEPESNTTI-- 337
+ + P+ L + N + + S +E EPE ++
Sbjct: 1240 QSIINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADKAPSQSESEPEKAPLCSVPP 1299
Query: 338 --DSSVLEVGDLQEPTQEELDQRFDEILAVDKED-IVKKWK---EEIGS-DKEILVAEIK 390
S+ E+G + TQ + + VDKED WK E G+ E+ + E++
Sbjct: 1300 PPPSAFAEMG--SDHTQSSASKISQD---VDKEDEFGYSWKNIRERYGTLTGELHMIELE 1354
Query: 391 K-LEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K GLG+SL G D R +I + P+G G G L DELLE+N L+G
Sbjct: 1355 KGHSGLGLSLAGNKD-----RSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGR 1409
Query: 450 THSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVK 509
+H +I+K P +V+++ RN + VN + G + S S N L
Sbjct: 1410 SHQNASSIIKCAPSKVKIIFIRN------KDAVNQMAVCPGNAVEPLPSNSEN----LQN 1459
Query: 510 AQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDY 569
+++ ++ TS A K + LE L K GLG +I +
Sbjct: 1460 KETEPTVTTSDAAV---DLSSFKNVQHLE----------------LPKDQGGLGIAISE- 1499
Query: 570 QDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRG 629
+D + + ++++SL GVA +G + GD++++V+ + +++ + LK A +
Sbjct: 1500 EDTL----SGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTA-KM 1554
Query: 630 TVKVGIARPLPPQDSSKS 647
TVK+ I P + S
Sbjct: 1555 TVKLTIHAENPDSQAVPS 1572
Score = 68.9 bits (161), Expect = 5e-11
Identities = 72/272 (26%), Positives = 115/272 (42%), Gaps = 26/272 (9%)
Query: 13 VELTNDGNGLGFNLVGG------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLR 66
VELT + GLG + G +G+ +K + + D R+Q GD ++ V NL+
Sbjct: 378 VELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQ 437
Query: 67 GFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVPTKILADPELLDRHLIET 126
GFT++Q VLR G V L + R A + TK AD ++ +I+
Sbjct: 438 GFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDV----TKD-ADLSPVNASIIKE 492
Query: 127 GYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQKIPDHPIVCDSVSPTITIT 186
Y D + NI E +++A + I D QK + + I
Sbjct: 493 NYEKDEDFLSSTRNTNIL-PTEEEGYPLLSAEIEEIED-AQK--QEAALLTKWQRIMGIN 548
Query: 187 VPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKIND 246
EI + HV GLGI++ V F++S++ SGK+ D
Sbjct: 549 Y-----EIVVAHVSKFSENSGLGISLEATVGHH------FIRSVLPEGPVGHSGKLFSGD 597
Query: 247 RIIEVDGISLADKSNPQSVEILRNTGISVHLV 278
++EV+GI+L +++ V IL+ I V +V
Sbjct: 598 ELLEVNGITLLGENHQDVVNILKELPIEVTMV 629
Score = 62.1 bits (144), Expect = 6e-09
Identities = 36/85 (42%), Positives = 50/85 (58%), Gaps = 2/85 (2%)
Query: 19 GNGLGFNLVGGRS-TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAVL 77
G GLG ++VG R+ TGV + ++ GG+AD D RL GD +L V ++R T E VAA+L
Sbjct: 1733 GKGLGLSIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALL 1792
Query: 78 RQAGPVVRLLVAR-PADPATALRAP 101
+ + V L V R A P + R P
Sbjct: 1793 KCSLGTVTLEVGRIKAGPFHSERRP 1817
Score = 59.3 bits (137), Expect = 4e-08
Identities = 67/285 (23%), Positives = 120/285 (42%), Gaps = 29/285 (10%)
Query: 379 GSDKEILVAEI-KKLEGLGISLEGTVDVEGGQELRPHH-YIRSVLPDGPVGLQGVLNAGD 436
G + E E+ K ++GLGI++ G + G ++L P +++S+ V G + GD
Sbjct: 370 GEESETFDVELTKNVQGLGITIAGYI---GDKKLEPSGIFVKSITKSSAVEHDGRIQIGD 426
Query: 437 ELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGP----RPVVNLASDREGFE 492
+++ V+ L G T+ + V +L+ V L R + R V +D
Sbjct: 427 QIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVN 486
Query: 493 ARKIISGSLNNLTTLVKAQSDTSI---NTSSTATLTNHSEQSKKSRSLECVSGLAMWQ-- 547
A II + + + +T+I L+ E+ + ++ E L WQ
Sbjct: 487 A-SIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAAL-LTKWQRI 544
Query: 548 ---SKEDIVMLVKA---DQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGD 601
+ E +V V + GLG S+ + V + +RS++P G +G++ GD
Sbjct: 545 MGINYEIVVAHVSKFSENSGLGISL---EATVGHH----FIRSVLPEGPVGHSGKLFSGD 597
Query: 602 RVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPLPPQDSSK 646
++ VNG+++ V LK P V R +PP S+
Sbjct: 598 ELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSE 642
Score = 59.3 bits (137), Expect = 4e-08
Identities = 58/206 (28%), Positives = 95/206 (46%), Gaps = 23/206 (11%)
Query: 8 AQVEVVELTNDGNGLGFNL------VGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVG 61
A ++ +EL GLGF++ + ST ++I+ ++PGG+A+KD RL GD ++ V
Sbjct: 696 AGIQHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVN 755
Query: 62 SVNLRGFTSEQVAAVLRQA-GPVVRLLVAR--PADPATALRAPQPGTALVPTKI-----L 113
VNL + E+ L+ A VR+ VA+ P P + + + L P L
Sbjct: 756 DVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSPEEGYVSAKEDSFLYPPHSCEEAGL 815
Query: 114 ADPELL--DRHLIETGYGAVYDLSQCYSDYN-INGQNGETETSIVAAAVSVIGDN---PQ 167
AD L D L+ T + D S S Y+ N T+ SI++ S GD
Sbjct: 816 ADKPLFRADLALVGTNDADLVDESTFESPYSPENDSIYSTQASILSLHGSSCGDGLNYGS 875
Query: 168 KIPDHP---IVCDSVSPTITITVPVE 190
+P P ++ +S P + + + +E
Sbjct: 876 SLPSSPPKDVIENSCDPVLDLHMSLE 901
Score = 57.6 bits (133), Expect = 1e-07
Identities = 32/85 (37%), Positives = 47/85 (55%), Gaps = 3/85 (3%)
Query: 13 VELTNDGNGLGFNLVGGRST---GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFT 69
+E++ GLG ++VGG T ++I V G A KD RL +GD +L+V ++LR T
Sbjct: 1630 IEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKAT 1689
Query: 70 SEQVAAVLRQAGPVVRLLVARPADP 94
++ VLRQ VRL + R P
Sbjct: 1690 HDEAINVLRQTPQRVRLTLYRDEAP 1714
Score = 57.2 bits (132), Expect = 2e-07
Identities = 63/278 (22%), Positives = 119/278 (42%), Gaps = 26/278 (9%)
Query: 377 EIGSDKEILVAEIKKLEG-LGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAG 435
++ S K + E+ K +G LGI++ + G I+S+ G G L G
Sbjct: 1474 DLSSFKNVQHLELPKDQGGLGIAISEEDTLSGV-------IIKSLTEHGVAATDGRLKVG 1526
Query: 436 DELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARK 495
D++L V++ + G + +++LK V+L + DS P A+ E
Sbjct: 1527 DQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGE------ 1580
Query: 496 IISGSLNNLTTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVML 555
N+ +L+ QS + ++ N S S + + + E + +
Sbjct: 1581 ----KKNSSQSLMVPQS----GSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEI 1632
Query: 556 VKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNAT 615
K GLG SI+ D + I++ + G A K+G + GD+++ VNG+ ++ AT
Sbjct: 1633 SKGRTGLGLSIVGGSDTLLG---AIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKAT 1689
Query: 616 LDQAVQALKGAPRGTVKVGIARPLPPQDSSKSKGTINV 653
D+A+ L+ P+ V++ + R P + T+ +
Sbjct: 1690 HDEAINVLRQTPQ-RVRLTLYRDEAPYKEEEVCDTLTI 1726
Score = 54.8 bits (126), Expect = 9e-07
Identities = 68/263 (25%), Positives = 113/263 (42%), Gaps = 34/263 (12%)
Query: 374 WKEEIGSDKEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLN 433
+KEE D + + K +GLG+S+ G + G ++ ++ G G L
Sbjct: 1715 YKEEEVCDTLTIELQKKPGKGLGLSIVGKRNDTGV-------FVSDIVKGGIADADGRLM 1767
Query: 434 AGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEA 493
GD++L VN + T V +LK V L R I +GP S+R ++
Sbjct: 1768 QGDQILMVNGEDVRNATQEAVAALLKCSLGTVTLEVGR--IKAGP-----FHSERRPSQS 1820
Query: 494 RKIISGSLNNLTTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIV 553
++ GSL++ T S ++T + SKK+ + GL + K+
Sbjct: 1821 SQVSEGSLSSFT----------FPLSGSSTSESLESSSKKNALASEIQGLRTVEMKKG-- 1868
Query: 554 MLVKADQGLGFSILDYQDPVDPNGTV-IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
LG SI P G V I + + P GVA + ++ GDR++++ G S +
Sbjct: 1869 ----PTDSLGISIAGGVG--SPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTE 1922
Query: 613 NATLDQAVQALKGAPRGTVKVGI 635
T QAV LK A G++++ +
Sbjct: 1923 GMTHTQAVNLLKNA-SGSIEMQV 1944
Score = 53.2 bits (122), Expect = 3e-06
Identities = 30/81 (37%), Positives = 47/81 (58%), Gaps = 6/81 (7%)
Query: 557 KADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATL 616
K +GLG SI+ + N T + V +V GG+A+ +G + GD+++ VNG ++NAT
Sbjct: 1731 KPGKGLGLSIVGKR-----NDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNAT- 1784
Query: 617 DQAVQALKGAPRGTVKVGIAR 637
+AV AL GTV + + R
Sbjct: 1785 QEAVAALLKCSLGTVTLEVGR 1805
Score = 52.4 bits (120), Expect = 5e-06
Identities = 28/85 (32%), Positives = 46/85 (54%), Gaps = 5/85 (5%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDHVLQVGSV 63
Q + + L +GLGF++VGG + + +K V G A +D RL+ GD ++ V
Sbjct: 1984 QCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQ 2043
Query: 64 NLRGFTSEQVAAVLRQAGPVVRLLV 88
+L G T E+ A+L++ V L+V
Sbjct: 2044 SLEGVTHEEAVAILKRTKGTVTLMV 2068
Score = 52.0 bits (119), Expect = 6e-06
Identities = 43/170 (25%), Positives = 82/170 (48%), Gaps = 17/170 (10%)
Query: 463 DRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTSSTA 522
DR+ +C ++ VNL + G ++++G +++ + Q + + ++ S
Sbjct: 1911 DRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGG--DVSVVTGHQQEPASSSLSFT 1968
Query: 523 TLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTV-IV 581
LT+ S +C S + L + GLGFSI+ P+G + I
Sbjct: 1969 GLTSSSIFQDDLGPPQCKS-----------ITLERGPDGLGFSIVGGYG--SPHGDLPIY 2015
Query: 582 VRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTV 631
V+++ G A ++G + GD++++VNG S++ T ++AV LK +GTV
Sbjct: 2016 VKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILK-RTKGTV 2064
Score = 50.4 bits (115), Expect = 2e-05
Identities = 28/76 (36%), Positives = 45/76 (59%), Gaps = 1/76 (1%)
Query: 207 GLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADK-SNPQSV 265
GLG +V G E GIFV+ I EGS A + G++K D+I+ ++G +L ++ Q++
Sbjct: 147 GLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAI 206
Query: 266 EILRNTGISVHLVLER 281
IL+ +V LV+ R
Sbjct: 207 SILQKAKDTVQLVIAR 222
Score = 50.4 bits (115), Expect = 2e-05
Identities = 39/122 (31%), Positives = 61/122 (50%), Gaps = 12/122 (9%)
Query: 163 GDNPQKIPDHPIVCDSVSPTITITV---PVELPEIEIIHVDLNKNVYGLGITVAGYVCEK 219
G PQ + PIV S S TI+ PV +E I +L + GLG + G
Sbjct: 223 GSLPQLVS--PIVSRSPSAASTISAHSNPVHWQHMETI--ELVNDGSGLGFGIIG----- 273
Query: 220 EELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
+ +G+ VK+I+ G A+Q G++ D I+++ LA S+ Q ++LR G V L++
Sbjct: 274 GKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMI 333
Query: 280 ER 281
R
Sbjct: 334 AR 335
Score = 50.4 bits (115), Expect = 2e-05
Identities = 31/110 (28%), Positives = 53/110 (48%), Gaps = 8/110 (7%)
Query: 528 SEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVP 587
S + ++ S WQ E I LV GLGF I + T ++V++++P
Sbjct: 234 SRSPSAASTISAHSNPVHWQHMETIE-LVNDGSGLGFGI------IGGKATGVIVKTILP 286
Query: 588 GGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIAR 637
GGVA+++G + GD ++ + + + +Q Q L+ VK+ IAR
Sbjct: 287 GGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQC-GNRVKLMIAR 335
Score = 50.4 bits (115), Expect = 2e-05
Identities = 27/94 (28%), Positives = 52/94 (55%), Gaps = 1/94 (1%)
Query: 177 DSVSPTITITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSG-IFVKSIIEGSS 235
D+ T + P+ + E I H++L K GLG ++ Y + S I ++S++ G
Sbjct: 679 DAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGI 738
Query: 236 AEQSGKIKINDRIIEVDGISLADKSNPQSVEILR 269
AE+ G++ DR++ V+ ++L + S ++VE L+
Sbjct: 739 AEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALK 772
Score = 50.0 bits (114), Expect = 3e-05
Identities = 67/297 (22%), Positives = 129/297 (43%), Gaps = 29/297 (9%)
Query: 5 TEWAQVEVVELTND-GNGLGFNLVGGRSTG-----------VVIKYVLPGGVADKDRRLQ 52
+ W Q VEL + LG ++VGGR G + IK+VL A K+ L+
Sbjct: 1144 SNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLK 1203
Query: 53 SGDHVLQVGSVNLRGFTSEQVAAVLRQAG-PV---VRLLVARP--ADPATALRAPQPGTA 106
GD +++V ++LR + EQ +R+AG PV V+ ++ RP + + L P
Sbjct: 1204 PGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYN 1263
Query: 107 LVPTKILADPELLDRHLIETGYGAVYDLSQ-CYSDYNINGQNGETETSIVAAAVSVIGDN 165
T AD ++ + + + + C E + ++ S I +
Sbjct: 1264 FSSTNPFADSLQINADKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQD 1323
Query: 166 PQKIPDHPIVCDSVSPTI-TITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSG 224
K + ++ T+T + + E+E H L G+++AG ++ +S
Sbjct: 1324 VDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGL-------GLSLAGNK-DRSRMS- 1374
Query: 225 IFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
+F+ I +A + G+++I D ++E++G L +S+ + I++ V ++ R
Sbjct: 1375 VFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIR 1431
Score = 50.0 bits (114), Expect = 3e-05
Identities = 28/104 (26%), Positives = 54/104 (51%), Gaps = 4/104 (3%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTGVVIKYVL---PGGVADKDRRLQSGDHVLQVGSVNL 65
++ ++EL +GLG +L G + + +++ P G A KD RLQ D +L++ L
Sbjct: 1347 ELHMIELEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQIL 1406
Query: 66 RGFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVP 109
G + + +++++ A V+++ R D + A PG A+ P
Sbjct: 1407 YGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQM-AVCPGNAVEP 1449
Score = 50.0 bits (114), Expect = 3e-05
Identities = 29/101 (28%), Positives = 57/101 (56%), Gaps = 6/101 (5%)
Query: 181 PTITIT-VPVELPEIEII-HVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQ 238
PT+T + V+L + + H++L K+ GLGI ++ E++ LSG+ +KS+ E A
Sbjct: 1464 PTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAIS----EEDTLSGVIIKSLTEHGVAAT 1519
Query: 239 SGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
G++K+ D+I+ VD + + + +L+ ++V L +
Sbjct: 1520 DGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTI 1560
Score = 48.8 bits (111), Expect = 6e-05
Identities = 36/125 (28%), Positives = 58/125 (46%), Gaps = 5/125 (4%)
Query: 503 NLTTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDI-VMLVKADQG 561
N L+ A+ T+ TA S + L + + E V L K QG
Sbjct: 327 NRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQKGEESETFDVELTKNVQG 386
Query: 562 LGFSILDY--QDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQA 619
LG +I Y ++P+G I V+S+ E +G I GD++++V+G ++Q T QA
Sbjct: 387 LGITIAGYIGDKKLEPSG--IFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQA 444
Query: 620 VQALK 624
V+ L+
Sbjct: 445 VEVLR 449
Score = 47.6 bits (108), Expect = 1e-04
Identities = 30/106 (28%), Positives = 54/106 (50%), Gaps = 4/106 (3%)
Query: 178 SVSPTITITVPVELPEIEIIH--VDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSS 235
S +P I + P P I ++++K GLG+++ G L I + + E +
Sbjct: 1607 SSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGG--SDTLLGAIIIHEVYEEGA 1664
Query: 236 AEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
A + G++ D+I+EV+GI L ++ +++ +LR T V L L R
Sbjct: 1665 ACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYR 1710
Score = 47.2 bits (107), Expect = 2e-04
Identities = 20/64 (31%), Positives = 39/64 (60%)
Query: 417 IRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDS 476
++++LP G G L +GD +L++ + L G++ +V +L+Q +RV+L+ AR +I+
Sbjct: 281 VKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARGAIEE 340
Query: 477 GPRP 480
P
Sbjct: 341 RTAP 344
Score = 46.4 bits (105), Expect = 3e-04
Identities = 35/138 (25%), Positives = 69/138 (50%), Gaps = 3/138 (2%)
Query: 143 INGQNGETETSIVAAA-VSVIGDNPQKIPDHPIVCDSVSPTITITVPVELPEIEIIHVDL 201
+ +G E +VA VSV+ + Q+ + ++ + + P+ + I ++
Sbjct: 1933 LKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKSITLER 1992
Query: 202 NKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSN 261
+ G I V GY +L I+VK++ +A + G++K D+II V+G SL ++
Sbjct: 1993 GPDGLGFSI-VGGYGSPHGDLP-IYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTH 2050
Query: 262 PQSVEILRNTGISVHLVL 279
++V IL+ T +V L++
Sbjct: 2051 EEAVAILKRTKGTVTLMV 2068
Score = 46.0 bits (104), Expect = 4e-04
Identities = 31/107 (28%), Positives = 58/107 (54%), Gaps = 5/107 (4%)
Query: 538 ECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTV-IVVRSLVPGGVAEKNGE 596
+ + +A + E +L GLGFS++ + + G + I V+ + G VA ++G
Sbjct: 124 QLIKNMAQGRHVEVFELLKPPSGGLGFSVVGLRS--ENRGELGIFVQEIQEGSVAHRDGR 181
Query: 597 ISPGDRVMSVNGVSI-QNATLDQAVQALKGAPRGTVKVGIARPLPPQ 642
+ D+++++NG ++ Q T QA+ L+ A + TV++ IAR PQ
Sbjct: 182 LKETDQILAINGQALDQTITHQQAISILQKA-KDTVQLVIARGSLPQ 227
Score = 44.0 bits (99), Expect = 0.002
Identities = 27/85 (31%), Positives = 46/85 (54%), Gaps = 1/85 (1%)
Query: 5 TEWAQVEVVELTNDGNGLGFNLVGGRS-TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSV 63
+ + V+ +EL D GLG + + +GV+IK + GVA D RL+ GD +L V
Sbjct: 1476 SSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDE 1535
Query: 64 NLRGFTSEQVAAVLRQAGPVVRLLV 88
+ G+ E+ ++L+ A V+L +
Sbjct: 1536 IVVGYPIEKFISLLKTAKMTVKLTI 1560
Score = 43.6 bits (98), Expect = 0.002
Identities = 27/76 (35%), Positives = 38/76 (50%), Gaps = 3/76 (3%)
Query: 393 EGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHS 452
+GLG S+ G G P Y+++V G G L GD+++ VN L G+TH
Sbjct: 1995 DGLGFSIVGGYGSPHGD--LPI-YVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHE 2051
Query: 453 EVVNILKQLPDRVRLV 468
E V ILK+ V L+
Sbjct: 2052 EAVAILKRTKGTVTLM 2067
Score = 42.3 bits (95), Expect = 0.005
Identities = 29/97 (29%), Positives = 50/97 (51%), Gaps = 6/97 (6%)
Query: 529 EQSKKSRSLECVS-GLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVP 587
EQS + + ECV +S E + + K + LG ++ +D G ++VRS++
Sbjct: 984 EQSSLACNAECVMLQNVSKESFERTINIAKGNSSLGMTVSANKD-----GLGMIVRSIIH 1038
Query: 588 GGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
GG ++G I+ GD ++S+N S + T QA L+
Sbjct: 1039 GGAISRDGRIAIGDCILSINEESTISVTNAQARAMLR 1075
Score = 39.1 bits (87), Expect = 0.049
Identities = 21/70 (30%), Positives = 38/70 (54%)
Query: 208 LGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEI 267
LGI++AG V IF+ + A Q+ K+++ DRI+ + G S ++ Q+V +
Sbjct: 1873 LGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNL 1932
Query: 268 LRNTGISVHL 277
L+N S+ +
Sbjct: 1933 LKNASGSIEM 1942
Score = 38.7 bits (86), Expect = 0.064
Identities = 22/80 (27%), Positives = 43/80 (53%), Gaps = 4/80 (5%)
Query: 207 GLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVE 266
GLG+++ G K +G+FV I++G A+ G++ D+I+ V+G + + +
Sbjct: 1735 GLGLSIVG----KRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAA 1790
Query: 267 ILRNTGISVHLVLERYLRGP 286
+L+ + +V L + R GP
Sbjct: 1791 LLKCSLGTVTLEVGRIKAGP 1810
Score = 37.9 bits (84), Expect = 0.11
Identities = 27/91 (29%), Positives = 45/91 (49%), Gaps = 4/91 (4%)
Query: 394 GLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRL-HGLTHS 452
GLG S+ G G EL +++ + G L D++L +N L +TH
Sbjct: 147 GLGFSVVGLRSENRG-ELGI--FVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQ 203
Query: 453 EVVNILKQLPDRVRLVCARNSIDSGPRPVVN 483
+ ++IL++ D V+LV AR S+ P+V+
Sbjct: 204 QAISILQKAKDTVQLVIARGSLPQLVSPIVS 234
Score = 37.5 bits (83), Expect = 0.15
Identities = 31/137 (22%), Positives = 58/137 (42%), Gaps = 4/137 (2%)
Query: 199 VDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLAD 258
+++ K LG+TV+ K+ L G+ V+SII G + + G+I I D I+ ++ S
Sbjct: 1009 INIAKGNSSLGMTVSA---NKDGL-GMIVRSIIHGGAISRDGRIAIGDCILSINEESTIS 1064
Query: 259 KSNPQSVEILRNTGISVHLVLERYLRGPKFEHLQLAIFNEERXXXXXXXXXXLSWFPVPS 318
+N Q+ +LR + + Y+ E ++++ + + +P
Sbjct: 1065 VTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDIPE 1124
Query: 319 QLENSITEIEPEPESNT 335
E E E NT
Sbjct: 1125 LPEREEGEGEESELQNT 1141
Score = 35.9 bits (79), Expect = 0.45
Identities = 23/80 (28%), Positives = 35/80 (43%), Gaps = 3/80 (3%)
Query: 17 NDGNGLGFNLVGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAV 76
N G G+ G I+ VLP G +L SGD +L+V + L G + V +
Sbjct: 562 NSGLGISLEATVGHH---FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNI 618
Query: 77 LRQAGPVVRLLVARPADPAT 96
L++ V ++ R P T
Sbjct: 619 LKELPIEVTMVCCRRTVPPT 638
Score = 33.9 bits (74), Expect = 1.8
Identities = 23/97 (23%), Positives = 45/97 (46%), Gaps = 6/97 (6%)
Query: 3 LSTEWAQVEVVELTNDG-NGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDH 56
L++E + VE+ + LG ++ GG + + I + P GVA + ++L+ GD
Sbjct: 1853 LASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDR 1912
Query: 57 VLQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVARPAD 93
++ + + G T Q +L+ A + + V D
Sbjct: 1913 IVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGD 1949
>AF093419-1|AAC61870.1| 2042|Homo sapiens multi PDZ domain protein
MUPP1 protein.
Length = 2042
Score = 293 bits (718), Expect = 2e-78
Identities = 201/479 (41%), Positives = 275/479 (57%), Gaps = 58/479 (12%)
Query: 178 SVSPTITITVPVELP-----EIEIIHVDLNKNVYGLGITVAGYVCEKE-ELSGIFVKSII 231
S SPT T + V+ E E V+L KNV GLGIT+AGY+ +K+ E SGIFVKSI
Sbjct: 352 SSSPTSTPELRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSIT 411
Query: 232 EGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHL 291
+ S+ E G+I+I D+II VDG +L +N Q+VE+LR+TG +V L L R RG K E
Sbjct: 412 KSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMR--RGMKQEA- 468
Query: 292 QLAIFNEERXXXXXXXXXXLSWFPVPSQLENSITEIEPEPESNTTIDSSVLEVGDLQEPT 351
E LS PV + + E + E ++T ++++L PT
Sbjct: 469 ------ELMSREDVTKDADLS--PVNASIIKENYE-KDEDFLSSTRNTNIL-------PT 512
Query: 352 QEE----LDQRFDEILAVDKED--IVKKWKEEIGSDKEILVAEIKKLE---GLGISLEGT 402
+EE L +EI K++ ++ KW+ +G + EI+VA + K GLGISLE T
Sbjct: 513 EEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEAT 572
Query: 403 VDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP 462
V HH+IRSVLP+GPVG G L +GDELLEVN L G H +VVNILK+LP
Sbjct: 573 VG---------HHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELP 623
Query: 463 DRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTSSTA 522
V +VC R ++ P D S L ++ K D S+
Sbjct: 624 IEVTMVCCRRTVP----PTTQSELD----------SLDLCDIELTEKPHVDLGEFIGSSE 669
Query: 523 TLTNHSEQSKKSRSLECVSG-LAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIV 581
T + +S E V LAMW++ + L K +GLGFSILDYQDP+DP TVI+
Sbjct: 670 TEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPASTVII 729
Query: 582 VRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPLP 640
+RSLVPGG+AEK+G + PGDR+M VN V+++N++L++AV+ALKGAP GTV++G+A+PLP
Sbjct: 730 IRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLP 788
Score = 114 bits (275), Expect = 8e-25
Identities = 49/86 (56%), Positives = 68/86 (79%)
Query: 7 WAQVEVVELTNDGNGLGFNLVGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLR 66
W +E +EL NDG+GLGF ++GG++TGV++K +LPGGVAD+ RL SGDH+L++G +L
Sbjct: 252 WQHMETIELVNDGSGLGFGIIGGKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLA 311
Query: 67 GFTSEQVAAVLRQAGPVVRLLVARPA 92
G +SEQVA VLRQ G V+L++AR A
Sbjct: 312 GMSSEQVAQVLRQCGNRVKLMIARGA 337
Score = 111 bits (267), Expect = 8e-24
Identities = 118/438 (26%), Positives = 197/438 (44%), Gaps = 55/438 (12%)
Query: 220 EELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
E + GIF+K ++E S A ++G +K DRI+EVDG+ L D S+ Q+VE +R G V ++
Sbjct: 1180 EVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMV 1239
Query: 280 ERYLRGPKFEHLQLAIFNEERXXXXXXXXXXLSWFPVPSQLENSITEIEPEPESNTTI-- 337
+ + P+ L + N + + S +E EPE ++
Sbjct: 1240 QSIINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADKAPSQSESEPEKAPLCSVPP 1299
Query: 338 --DSSVLEVGDLQEPTQEELDQRFDEILAVDKED-IVKKWK---EEIGS-DKEILVAEIK 390
S+ E+G + TQ + + VDKED WK E G+ E+ + E++
Sbjct: 1300 PPPSAFAEMG--SDHTQSSASKISQD---VDKEDEFGYSWKNIRERYGTLTGELHMIELE 1354
Query: 391 K-LEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K GLG+SL G D R +I + P+G G G L DELLE+N L+G
Sbjct: 1355 KGHSGLGLSLAGNKD-----RSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGR 1409
Query: 450 THSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVK 509
+H +I+K P +V+++ RN + VN + G + S S N L
Sbjct: 1410 SHQNASSIIKCAPSKVKIIFIRN------KDAVNQMAVCPGNAVEPLPSNSEN----LQN 1459
Query: 510 AQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDY 569
+++ ++ TS A K + LE L K GLG +I +
Sbjct: 1460 KETEPTVTTSDAAV---DLSSFKNVQHLE----------------LPKDQGGLGIAISE- 1499
Query: 570 QDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRG 629
+D + + ++++SL GVA +G + GD++++V+ + +++ + LK A +
Sbjct: 1500 EDTL----SGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTA-KM 1554
Query: 630 TVKVGIARPLPPQDSSKS 647
TVK+ I P + S
Sbjct: 1555 TVKLTIHAENPDSQAVPS 1572
Score = 68.9 bits (161), Expect = 5e-11
Identities = 72/272 (26%), Positives = 115/272 (42%), Gaps = 26/272 (9%)
Query: 13 VELTNDGNGLGFNLVGG------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLR 66
VELT + GLG + G +G+ +K + + D R+Q GD ++ V NL+
Sbjct: 378 VELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQ 437
Query: 67 GFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVPTKILADPELLDRHLIET 126
GFT++Q VLR G V L + R A + TK AD ++ +I+
Sbjct: 438 GFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDV----TKD-ADLSPVNASIIKE 492
Query: 127 GYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQKIPDHPIVCDSVSPTITIT 186
Y D + NI E +++A + I D QK + + I
Sbjct: 493 NYEKDEDFLSSTRNTNIL-PTEEEGYPLLSAEIEEIED-AQK--QEAALLTKWQRIMGIN 548
Query: 187 VPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKIND 246
EI + HV GLGI++ V F++S++ SGK+ D
Sbjct: 549 Y-----EIVVAHVSKFSENSGLGISLEATVGHH------FIRSVLPEGPVGHSGKLFSGD 597
Query: 247 RIIEVDGISLADKSNPQSVEILRNTGISVHLV 278
++EV+GI+L +++ V IL+ I V +V
Sbjct: 598 ELLEVNGITLLGENHQDVVNILKELPIEVTMV 629
Score = 66.9 bits (156), Expect = 2e-10
Identities = 74/285 (25%), Positives = 125/285 (43%), Gaps = 20/285 (7%)
Query: 13 VELTNDGNGLGFNLVGGRST---GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFT 69
+E++ GLG ++VGG T ++I V G A KD RL +GD +L+V ++LR T
Sbjct: 1630 IEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKAT 1689
Query: 70 SEQVAAVLRQAGPVVRLLVARP---------ADPATALRAPQPGTALVPTKI--LADPEL 118
++ VLRQ VRL + R D T +PG L + + D +
Sbjct: 1690 HDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGKRNDTGV 1749
Query: 119 LDRHLIETGYG-AVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQKIPDHPIVC- 176
+++ G A L Q +NG++ T AA+ + I
Sbjct: 1750 FVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKCSLGTVTLEVGRIKAG 1809
Query: 177 DSVSPTITITVPVEL--PEIEIIH-VDLNKN-VYGLGITVAGYVCEKEELSGIFVKSIIE 232
S S ++ + EI+ + V++ K LGI++AG V IF+ +
Sbjct: 1810 SSTSESLESSSKKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHP 1869
Query: 233 GSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHL 277
A Q+ K+++ DRI+ + G S ++ Q+V +L+N S+ +
Sbjct: 1870 TGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEM 1914
Score = 59.3 bits (137), Expect = 4e-08
Identities = 67/285 (23%), Positives = 120/285 (42%), Gaps = 29/285 (10%)
Query: 379 GSDKEILVAEI-KKLEGLGISLEGTVDVEGGQELRPHH-YIRSVLPDGPVGLQGVLNAGD 436
G + E E+ K ++GLGI++ G + G ++L P +++S+ V G + GD
Sbjct: 370 GEESETFDVELTKNVQGLGITIAGYI---GDKKLEPSGIFVKSITKSSAVEHDGRIQIGD 426
Query: 437 ELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGP----RPVVNLASDREGFE 492
+++ V+ L G T+ + V +L+ V L R + R V +D
Sbjct: 427 QIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVN 486
Query: 493 ARKIISGSLNNLTTLVKAQSDTSI---NTSSTATLTNHSEQSKKSRSLECVSGLAMWQ-- 547
A II + + + +T+I L+ E+ + ++ E L WQ
Sbjct: 487 A-SIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAAL-LTKWQRI 544
Query: 548 ---SKEDIVMLVKA---DQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGD 601
+ E +V V + GLG S+ + V + +RS++P G +G++ GD
Sbjct: 545 MGINYEIVVAHVSKFSENSGLGISL---EATVGHH----FIRSVLPEGPVGHSGKLFSGD 597
Query: 602 RVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPLPPQDSSK 646
++ VNG+++ V LK P V R +PP S+
Sbjct: 598 ELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSE 642
Score = 59.3 bits (137), Expect = 4e-08
Identities = 58/206 (28%), Positives = 95/206 (46%), Gaps = 23/206 (11%)
Query: 8 AQVEVVELTNDGNGLGFNL------VGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVG 61
A ++ +EL GLGF++ + ST ++I+ ++PGG+A+KD RL GD ++ V
Sbjct: 696 AGIQHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVN 755
Query: 62 SVNLRGFTSEQVAAVLRQA-GPVVRLLVAR--PADPATALRAPQPGTALVPTKI-----L 113
VNL + E+ L+ A VR+ VA+ P P + + + L P L
Sbjct: 756 DVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSPEEGYVSAKEDSFLYPPHSCEEAGL 815
Query: 114 ADPELL--DRHLIETGYGAVYDLSQCYSDYN-INGQNGETETSIVAAAVSVIGDN---PQ 167
AD L D L+ T + D S S Y+ N T+ SI++ S GD
Sbjct: 816 ADKPLFRADLALVGTNDADLVDESTFESPYSPENDSIYSTQASILSLHGSSCGDGLNYGS 875
Query: 168 KIPDHP---IVCDSVSPTITITVPVE 190
+P P ++ +S P + + + +E
Sbjct: 876 SLPSSPPKDVIENSCDPVLDLHMSLE 901
Score = 57.2 bits (132), Expect = 2e-07
Identities = 63/278 (22%), Positives = 119/278 (42%), Gaps = 26/278 (9%)
Query: 377 EIGSDKEILVAEIKKLEG-LGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAG 435
++ S K + E+ K +G LGI++ + G I+S+ G G L G
Sbjct: 1474 DLSSFKNVQHLELPKDQGGLGIAISEEDTLSGV-------IIKSLTEHGVAATDGRLKVG 1526
Query: 436 DELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARK 495
D++L V++ + G + +++LK V+L + DS P A+ E
Sbjct: 1527 DQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGE------ 1580
Query: 496 IISGSLNNLTTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVML 555
N+ +L+ QS + ++ N S S + + + E + +
Sbjct: 1581 ----KKNSSQSLMVPQS----GSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEI 1632
Query: 556 VKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNAT 615
K GLG SI+ D + I++ + G A K+G + GD+++ VNG+ ++ AT
Sbjct: 1633 SKGRTGLGLSIVGGSDTLLG---AIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKAT 1689
Query: 616 LDQAVQALKGAPRGTVKVGIARPLPPQDSSKSKGTINV 653
D+A+ L+ P+ V++ + R P + T+ +
Sbjct: 1690 HDEAINVLRQTPQ-RVRLTLYRDEAPYKEEEVCDTLTI 1726
Score = 54.0 bits (124), Expect = 2e-06
Identities = 32/91 (35%), Positives = 51/91 (56%), Gaps = 6/91 (6%)
Query: 557 KADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATL 616
K +GLG SI+ + N T + V +V GG+A+ +G + GD+++ VNG ++NAT
Sbjct: 1731 KPGKGLGLSIVGKR-----NDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNAT- 1784
Query: 617 DQAVQALKGAPRGTVKVGIARPLPPQDSSKS 647
+AV AL GTV + + R +S+S
Sbjct: 1785 QEAVAALLKCSLGTVTLEVGRIKAGSSTSES 1815
Score = 52.4 bits (120), Expect = 5e-06
Identities = 28/85 (32%), Positives = 46/85 (54%), Gaps = 5/85 (5%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDHVLQVGSV 63
Q + + L +GLGF++VGG + + +K V G A +D RL+ GD ++ V
Sbjct: 1956 QCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQ 2015
Query: 64 NLRGFTSEQVAAVLRQAGPVVRLLV 88
+L G T E+ A+L++ V L+V
Sbjct: 2016 SLEGVTHEEAVAILKRTKGTVTLMV 2040
Score = 52.0 bits (119), Expect = 6e-06
Identities = 43/170 (25%), Positives = 82/170 (48%), Gaps = 17/170 (10%)
Query: 463 DRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTSSTA 522
DR+ +C ++ VNL + G ++++G +++ + Q + + ++ S
Sbjct: 1883 DRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGG--DVSVVTGHQQEPASSSLSFT 1940
Query: 523 TLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTV-IV 581
LT+ S +C S + L + GLGFSI+ P+G + I
Sbjct: 1941 GLTSSSIFQDDLGPPQCKS-----------ITLERGPDGLGFSIVGGYG--SPHGDLPIY 1987
Query: 582 VRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTV 631
V+++ G A ++G + GD++++VNG S++ T ++AV LK +GTV
Sbjct: 1988 VKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILK-RTKGTV 2036
Score = 50.4 bits (115), Expect = 2e-05
Identities = 28/76 (36%), Positives = 45/76 (59%), Gaps = 1/76 (1%)
Query: 207 GLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADK-SNPQSV 265
GLG +V G E GIFV+ I EGS A + G++K D+I+ ++G +L ++ Q++
Sbjct: 147 GLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAI 206
Query: 266 EILRNTGISVHLVLER 281
IL+ +V LV+ R
Sbjct: 207 SILQKAKDTVQLVIAR 222
Score = 50.4 bits (115), Expect = 2e-05
Identities = 39/122 (31%), Positives = 61/122 (50%), Gaps = 12/122 (9%)
Query: 163 GDNPQKIPDHPIVCDSVSPTITITV---PVELPEIEIIHVDLNKNVYGLGITVAGYVCEK 219
G PQ + PIV S S TI+ PV +E I +L + GLG + G
Sbjct: 223 GSLPQLVS--PIVSRSPSAASTISAHSNPVHWQHMETI--ELVNDGSGLGFGIIG----- 273
Query: 220 EELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
+ +G+ VK+I+ G A+Q G++ D I+++ LA S+ Q ++LR G V L++
Sbjct: 274 GKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMI 333
Query: 280 ER 281
R
Sbjct: 334 AR 335
Score = 50.4 bits (115), Expect = 2e-05
Identities = 31/110 (28%), Positives = 53/110 (48%), Gaps = 8/110 (7%)
Query: 528 SEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVP 587
S + ++ S WQ E I LV GLGF I + T ++V++++P
Sbjct: 234 SRSPSAASTISAHSNPVHWQHMETIE-LVNDGSGLGFGI------IGGKATGVIVKTILP 286
Query: 588 GGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIAR 637
GGVA+++G + GD ++ + + + +Q Q L+ VK+ IAR
Sbjct: 287 GGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQC-GNRVKLMIAR 335
Score = 50.4 bits (115), Expect = 2e-05
Identities = 27/94 (28%), Positives = 52/94 (55%), Gaps = 1/94 (1%)
Query: 177 DSVSPTITITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSG-IFVKSIIEGSS 235
D+ T + P+ + E I H++L K GLG ++ Y + S I ++S++ G
Sbjct: 679 DAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGI 738
Query: 236 AEQSGKIKINDRIIEVDGISLADKSNPQSVEILR 269
AE+ G++ DR++ V+ ++L + S ++VE L+
Sbjct: 739 AEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALK 772
Score = 50.0 bits (114), Expect = 3e-05
Identities = 67/297 (22%), Positives = 129/297 (43%), Gaps = 29/297 (9%)
Query: 5 TEWAQVEVVELTND-GNGLGFNLVGGRSTG-----------VVIKYVLPGGVADKDRRLQ 52
+ W Q VEL + LG ++VGGR G + IK+VL A K+ L+
Sbjct: 1144 SNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLK 1203
Query: 53 SGDHVLQVGSVNLRGFTSEQVAAVLRQAG-PV---VRLLVARP--ADPATALRAPQPGTA 106
GD +++V ++LR + EQ +R+AG PV V+ ++ RP + + L P
Sbjct: 1204 PGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYN 1263
Query: 107 LVPTKILADPELLDRHLIETGYGAVYDLSQ-CYSDYNINGQNGETETSIVAAAVSVIGDN 165
T AD ++ + + + + C E + ++ S I +
Sbjct: 1264 FSSTNPFADSLQINADKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQD 1323
Query: 166 PQKIPDHPIVCDSVSPTI-TITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSG 224
K + ++ T+T + + E+E H L G+++AG ++ +S
Sbjct: 1324 VDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGL-------GLSLAGNK-DRSRMS- 1374
Query: 225 IFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
+F+ I +A + G+++I D ++E++G L +S+ + I++ V ++ R
Sbjct: 1375 VFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIR 1431
Score = 50.0 bits (114), Expect = 3e-05
Identities = 28/104 (26%), Positives = 54/104 (51%), Gaps = 4/104 (3%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTGVVIKYVL---PGGVADKDRRLQSGDHVLQVGSVNL 65
++ ++EL +GLG +L G + + +++ P G A KD RLQ D +L++ L
Sbjct: 1347 ELHMIELEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQIL 1406
Query: 66 RGFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVP 109
G + + +++++ A V+++ R D + A PG A+ P
Sbjct: 1407 YGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQM-AVCPGNAVEP 1449
Score = 50.0 bits (114), Expect = 3e-05
Identities = 29/101 (28%), Positives = 57/101 (56%), Gaps = 6/101 (5%)
Query: 181 PTITIT-VPVELPEIEII-HVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQ 238
PT+T + V+L + + H++L K+ GLGI ++ E++ LSG+ +KS+ E A
Sbjct: 1464 PTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAIS----EEDTLSGVIIKSLTEHGVAAT 1519
Query: 239 SGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
G++K+ D+I+ VD + + + +L+ ++V L +
Sbjct: 1520 DGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTI 1560
Score = 48.8 bits (111), Expect = 6e-05
Identities = 36/125 (28%), Positives = 58/125 (46%), Gaps = 5/125 (4%)
Query: 503 NLTTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDI-VMLVKADQG 561
N L+ A+ T+ TA S + L + + E V L K QG
Sbjct: 327 NRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQKGEESETFDVELTKNVQG 386
Query: 562 LGFSILDY--QDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQA 619
LG +I Y ++P+G I V+S+ E +G I GD++++V+G ++Q T QA
Sbjct: 387 LGITIAGYIGDKKLEPSG--IFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQA 444
Query: 620 VQALK 624
V+ L+
Sbjct: 445 VEVLR 449
Score = 47.6 bits (108), Expect = 1e-04
Identities = 30/106 (28%), Positives = 54/106 (50%), Gaps = 4/106 (3%)
Query: 178 SVSPTITITVPVELPEIEIIH--VDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSS 235
S +P I + P P I ++++K GLG+++ G L I + + E +
Sbjct: 1607 SSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGG--SDTLLGAIIIHEVYEEGA 1664
Query: 236 AEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
A + G++ D+I+EV+GI L ++ +++ +LR T V L L R
Sbjct: 1665 ACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYR 1710
Score = 47.2 bits (107), Expect = 2e-04
Identities = 20/64 (31%), Positives = 39/64 (60%)
Query: 417 IRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDS 476
++++LP G G L +GD +L++ + L G++ +V +L+Q +RV+L+ AR +I+
Sbjct: 281 VKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARGAIEE 340
Query: 477 GPRP 480
P
Sbjct: 341 RTAP 344
Score = 46.4 bits (105), Expect = 3e-04
Identities = 35/138 (25%), Positives = 69/138 (50%), Gaps = 3/138 (2%)
Query: 143 INGQNGETETSIVAAA-VSVIGDNPQKIPDHPIVCDSVSPTITITVPVELPEIEIIHVDL 201
+ +G E +VA VSV+ + Q+ + ++ + + P+ + I ++
Sbjct: 1905 LKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKSITLER 1964
Query: 202 NKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSN 261
+ G I V GY +L I+VK++ +A + G++K D+II V+G SL ++
Sbjct: 1965 GPDGLGFSI-VGGYGSPHGDLP-IYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTH 2022
Query: 262 PQSVEILRNTGISVHLVL 279
++V IL+ T +V L++
Sbjct: 2023 EEAVAILKRTKGTVTLMV 2040
Score = 46.0 bits (104), Expect = 4e-04
Identities = 31/107 (28%), Positives = 58/107 (54%), Gaps = 5/107 (4%)
Query: 538 ECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTV-IVVRSLVPGGVAEKNGE 596
+ + +A + E +L GLGFS++ + + G + I V+ + G VA ++G
Sbjct: 124 QLIKNMAQGRHVEVFELLKPPSGGLGFSVVGLRS--ENRGELGIFVQEIQEGSVAHRDGR 181
Query: 597 ISPGDRVMSVNGVSI-QNATLDQAVQALKGAPRGTVKVGIARPLPPQ 642
+ D+++++NG ++ Q T QA+ L+ A + TV++ IAR PQ
Sbjct: 182 LKETDQILAINGQALDQTITHQQAISILQKA-KDTVQLVIARGSLPQ 227
Score = 44.0 bits (99), Expect = 0.002
Identities = 27/85 (31%), Positives = 46/85 (54%), Gaps = 1/85 (1%)
Query: 5 TEWAQVEVVELTNDGNGLGFNLVGGRS-TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSV 63
+ + V+ +EL D GLG + + +GV+IK + GVA D RL+ GD +L V
Sbjct: 1476 SSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDE 1535
Query: 64 NLRGFTSEQVAAVLRQAGPVVRLLV 88
+ G+ E+ ++L+ A V+L +
Sbjct: 1536 IVVGYPIEKFISLLKTAKMTVKLTI 1560
Score = 43.6 bits (98), Expect = 0.002
Identities = 27/76 (35%), Positives = 38/76 (50%), Gaps = 3/76 (3%)
Query: 393 EGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHS 452
+GLG S+ G G P Y+++V G G L GD+++ VN L G+TH
Sbjct: 1967 DGLGFSIVGGYGSPHGD--LPI-YVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHE 2023
Query: 453 EVVNILKQLPDRVRLV 468
E V ILK+ V L+
Sbjct: 2024 EAVAILKRTKGTVTLM 2039
Score = 42.3 bits (95), Expect = 0.005
Identities = 29/97 (29%), Positives = 50/97 (51%), Gaps = 6/97 (6%)
Query: 529 EQSKKSRSLECVS-GLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVP 587
EQS + + ECV +S E + + K + LG ++ +D G ++VRS++
Sbjct: 984 EQSSLACNAECVMLQNVSKESFERTINIAKGNSSLGMTVSANKD-----GLGMIVRSIIH 1038
Query: 588 GGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
GG ++G I+ GD ++S+N S + T QA L+
Sbjct: 1039 GGAISRDGRIAIGDCILSINEESTISVTNAQARAMLR 1075
Score = 37.9 bits (84), Expect = 0.11
Identities = 27/91 (29%), Positives = 45/91 (49%), Gaps = 4/91 (4%)
Query: 394 GLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRL-HGLTHS 452
GLG S+ G G EL +++ + G L D++L +N L +TH
Sbjct: 147 GLGFSVVGLRSENRG-ELGI--FVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQ 203
Query: 453 EVVNILKQLPDRVRLVCARNSIDSGPRPVVN 483
+ ++IL++ D V+LV AR S+ P+V+
Sbjct: 204 QAISILQKAKDTVQLVIARGSLPQLVSPIVS 234
Score = 37.5 bits (83), Expect = 0.15
Identities = 31/137 (22%), Positives = 58/137 (42%), Gaps = 4/137 (2%)
Query: 199 VDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLAD 258
+++ K LG+TV+ K+ L G+ V+SII G + + G+I I D I+ ++ S
Sbjct: 1009 INIAKGNSSLGMTVSA---NKDGL-GMIVRSIIHGGAISRDGRIAIGDCILSINEESTIS 1064
Query: 259 KSNPQSVEILRNTGISVHLVLERYLRGPKFEHLQLAIFNEERXXXXXXXXXXLSWFPVPS 318
+N Q+ +LR + + Y+ E ++++ + + +P
Sbjct: 1065 VTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDIPE 1124
Query: 319 QLENSITEIEPEPESNT 335
E E E NT
Sbjct: 1125 LPEREEGEGEESELQNT 1141
Score = 36.7 bits (81), Expect = 0.26
Identities = 21/62 (33%), Positives = 36/62 (58%), Gaps = 2/62 (3%)
Query: 575 PNGTV-IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKV 633
P G V I + + P GVA + ++ GDR++++ G S + T QAV LK A G++++
Sbjct: 1856 PLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNA-SGSIEM 1914
Query: 634 GI 635
+
Sbjct: 1915 QV 1916
Score = 35.9 bits (79), Expect = 0.45
Identities = 23/80 (28%), Positives = 35/80 (43%), Gaps = 3/80 (3%)
Query: 17 NDGNGLGFNLVGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAV 76
N G G+ G I+ VLP G +L SGD +L+V + L G + V +
Sbjct: 562 NSGLGISLEATVGHH---FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNI 618
Query: 77 LRQAGPVVRLLVARPADPAT 96
L++ V ++ R P T
Sbjct: 619 LKELPIEVTMVCCRRTVPPT 638
Score = 35.9 bits (79), Expect = 0.45
Identities = 21/79 (26%), Positives = 42/79 (53%), Gaps = 4/79 (5%)
Query: 207 GLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVE 266
GLG+++ G K +G+FV I++G A+ G++ D+I+ V+G + + +
Sbjct: 1735 GLGLSIVG----KRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAA 1790
Query: 267 ILRNTGISVHLVLERYLRG 285
+L+ + +V L + R G
Sbjct: 1791 LLKCSLGTVTLEVGRIKAG 1809
Score = 33.9 bits (74), Expect = 1.8
Identities = 23/97 (23%), Positives = 45/97 (46%), Gaps = 6/97 (6%)
Query: 3 LSTEWAQVEVVELTNDG-NGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDH 56
L++E + VE+ + LG ++ GG + + I + P GVA + ++L+ GD
Sbjct: 1825 LASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDR 1884
Query: 57 VLQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVARPAD 93
++ + + G T Q +L+ A + + V D
Sbjct: 1885 IVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGD 1921
Score = 32.7 bits (71), Expect = 4.2
Identities = 23/82 (28%), Positives = 37/82 (45%), Gaps = 5/82 (6%)
Query: 388 EIKK--LEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYR 445
E+KK + LGIS+ G V G +I + P G L GD ++ +
Sbjct: 1836 EMKKGPTDSLGISIAGGVGSPLGDV---PIFIAMMHPTGVAAQTQKLRVGDRIVTICGTS 1892
Query: 446 LHGLTHSEVVNILKQLPDRVRL 467
G+TH++ VN+LK + +
Sbjct: 1893 TEGMTHTQAVNLLKNASGSIEM 1914
>AB210041-1|BAE06123.1| 2045|Homo sapiens MPDZ variant protein
protein.
Length = 2045
Score = 293 bits (718), Expect = 2e-78
Identities = 201/479 (41%), Positives = 275/479 (57%), Gaps = 58/479 (12%)
Query: 178 SVSPTITITVPVELP-----EIEIIHVDLNKNVYGLGITVAGYVCEKE-ELSGIFVKSII 231
S SPT T + V+ E E V+L KNV GLGIT+AGY+ +K+ E SGIFVKSI
Sbjct: 356 SSSPTSTPELRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSIT 415
Query: 232 EGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHL 291
+ S+ E G+I+I D+II VDG +L +N Q+VE+LR+TG +V L L R RG K E
Sbjct: 416 KSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMR--RGMKQEA- 472
Query: 292 QLAIFNEERXXXXXXXXXXLSWFPVPSQLENSITEIEPEPESNTTIDSSVLEVGDLQEPT 351
E LS PV + + E + E ++T ++++L PT
Sbjct: 473 ------ELMSREDVTKDADLS--PVNASIIKENYE-KDEDFLSSTRNTNIL-------PT 516
Query: 352 QEE----LDQRFDEILAVDKED--IVKKWKEEIGSDKEILVAEIKKLE---GLGISLEGT 402
+EE L +EI K++ ++ KW+ +G + EI+VA + K GLGISLE T
Sbjct: 517 EEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEAT 576
Query: 403 VDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP 462
V HH+IRSVLP+GPVG G L +GDELLEVN L G H +VVNILK+LP
Sbjct: 577 VG---------HHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELP 627
Query: 463 DRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTSSTA 522
V +VC R ++ P D S L ++ K D S+
Sbjct: 628 IEVTMVCCRRTVP----PTTQSELD----------SLDLCDIELTEKPHVDLGEFIGSSE 673
Query: 523 TLTNHSEQSKKSRSLECVSG-LAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIV 581
T + +S E V LAMW++ + L K +GLGFSILDYQDP+DP TVI+
Sbjct: 674 TEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPASTVII 733
Query: 582 VRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPLP 640
+RSLVPGG+AEK+G + PGDR+M VN V+++N++L++AV+ALKGAP GTV++G+A+PLP
Sbjct: 734 IRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLP 792
Score = 114 bits (275), Expect = 8e-25
Identities = 49/86 (56%), Positives = 68/86 (79%)
Query: 7 WAQVEVVELTNDGNGLGFNLVGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLR 66
W +E +EL NDG+GLGF ++GG++TGV++K +LPGGVAD+ RL SGDH+L++G +L
Sbjct: 256 WQHMETIELVNDGSGLGFGIIGGKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLA 315
Query: 67 GFTSEQVAAVLRQAGPVVRLLVARPA 92
G +SEQVA VLRQ G V+L++AR A
Sbjct: 316 GMSSEQVAQVLRQCGNRVKLMIARGA 341
Score = 111 bits (267), Expect = 8e-24
Identities = 118/438 (26%), Positives = 197/438 (44%), Gaps = 55/438 (12%)
Query: 220 EELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
E + GIF+K ++E S A ++G +K DRI+EVDG+ L D S+ Q+VE +R G V ++
Sbjct: 1184 EVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMV 1243
Query: 280 ERYLRGPKFEHLQLAIFNEERXXXXXXXXXXLSWFPVPSQLENSITEIEPEPESNTTI-- 337
+ + P+ L + N + + S +E EPE ++
Sbjct: 1244 QSIINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADKAPSQSESEPEKAPLCSVPP 1303
Query: 338 --DSSVLEVGDLQEPTQEELDQRFDEILAVDKED-IVKKWK---EEIGS-DKEILVAEIK 390
S+ E+G + TQ + + VDKED WK E G+ E+ + E++
Sbjct: 1304 PPPSAFAEMG--SDHTQSSASKISQD---VDKEDEFGYSWKNIRERYGTLTGELHMIELE 1358
Query: 391 K-LEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K GLG+SL G D R +I + P+G G G L DELLE+N L+G
Sbjct: 1359 KGHSGLGLSLAGNKD-----RSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGR 1413
Query: 450 THSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVK 509
+H +I+K P +V+++ RN + VN + G + S S N L
Sbjct: 1414 SHQNASSIIKCAPSKVKIIFIRN------KDAVNQMAVCPGNAVEPLPSNSEN----LQN 1463
Query: 510 AQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDY 569
+++ ++ TS A K + LE L K GLG +I +
Sbjct: 1464 KETEPTVTTSDAAV---DLSSFKNVQHLE----------------LPKDQGGLGIAISE- 1503
Query: 570 QDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRG 629
+D + + ++++SL GVA +G + GD++++V+ + +++ + LK A +
Sbjct: 1504 EDTL----SGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTA-KM 1558
Query: 630 TVKVGIARPLPPQDSSKS 647
TVK+ I P + S
Sbjct: 1559 TVKLTIHAENPDSQAVPS 1576
Score = 75.8 bits (178), Expect = 5e-13
Identities = 74/284 (26%), Positives = 127/284 (44%), Gaps = 19/284 (6%)
Query: 13 VELTNDGNGLGFNLVGGRST---GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFT 69
+E++ GLG ++VGG T ++I V G A KD RL +GD +L+V ++LR T
Sbjct: 1634 IEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKAT 1693
Query: 70 SEQVAAVLRQAGPVVRLLVARP---------ADPATALRAPQPGTALVPTKI--LADPEL 118
++ VLRQ VRL + R D T +PG L + + D +
Sbjct: 1694 HDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGKRNDTGV 1753
Query: 119 LDRHLIETGYG-AVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQKIPDHPIVCD 177
+++ G A L Q +NG++ T AA+ + + P+
Sbjct: 1754 FVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVSEGSLSSFTFPLSGS 1813
Query: 178 SVSPTITITVPVE--LPEIEIIH-VDLNKN-VYGLGITVAGYVCEKEELSGIFVKSIIEG 233
S S ++ + EI+ + V++ K LGI++AG V IF+ +
Sbjct: 1814 STSESLESSSKKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPT 1873
Query: 234 SSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHL 277
A Q+ K+++ DRI+ + G S ++ Q+V +L+N S+ +
Sbjct: 1874 GVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEM 1917
Score = 68.9 bits (161), Expect = 5e-11
Identities = 72/272 (26%), Positives = 115/272 (42%), Gaps = 26/272 (9%)
Query: 13 VELTNDGNGLGFNLVGG------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLR 66
VELT + GLG + G +G+ +K + + D R+Q GD ++ V NL+
Sbjct: 382 VELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQ 441
Query: 67 GFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVPTKILADPELLDRHLIET 126
GFT++Q VLR G V L + R A + TK AD ++ +I+
Sbjct: 442 GFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDV----TKD-ADLSPVNASIIKE 496
Query: 127 GYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQKIPDHPIVCDSVSPTITIT 186
Y D + NI E +++A + I D QK + + I
Sbjct: 497 NYEKDEDFLSSTRNTNIL-PTEEEGYPLLSAEIEEIED-AQK--QEAALLTKWQRIMGIN 552
Query: 187 VPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKIND 246
EI + HV GLGI++ V F++S++ SGK+ D
Sbjct: 553 Y-----EIVVAHVSKFSENSGLGISLEATVGHH------FIRSVLPEGPVGHSGKLFSGD 601
Query: 247 RIIEVDGISLADKSNPQSVEILRNTGISVHLV 278
++EV+GI+L +++ V IL+ I V +V
Sbjct: 602 ELLEVNGITLLGENHQDVVNILKELPIEVTMV 633
Score = 59.3 bits (137), Expect = 4e-08
Identities = 67/285 (23%), Positives = 120/285 (42%), Gaps = 29/285 (10%)
Query: 379 GSDKEILVAEI-KKLEGLGISLEGTVDVEGGQELRPHH-YIRSVLPDGPVGLQGVLNAGD 436
G + E E+ K ++GLGI++ G + G ++L P +++S+ V G + GD
Sbjct: 374 GEESETFDVELTKNVQGLGITIAGYI---GDKKLEPSGIFVKSITKSSAVEHDGRIQIGD 430
Query: 437 ELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGP----RPVVNLASDREGFE 492
+++ V+ L G T+ + V +L+ V L R + R V +D
Sbjct: 431 QIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVN 490
Query: 493 ARKIISGSLNNLTTLVKAQSDTSI---NTSSTATLTNHSEQSKKSRSLECVSGLAMWQ-- 547
A II + + + +T+I L+ E+ + ++ E L WQ
Sbjct: 491 A-SIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAAL-LTKWQRI 548
Query: 548 ---SKEDIVMLVKA---DQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGD 601
+ E +V V + GLG S+ + V + +RS++P G +G++ GD
Sbjct: 549 MGINYEIVVAHVSKFSENSGLGISL---EATVGHH----FIRSVLPEGPVGHSGKLFSGD 601
Query: 602 RVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPLPPQDSSK 646
++ VNG+++ V LK P V R +PP S+
Sbjct: 602 ELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSE 646
Score = 59.3 bits (137), Expect = 4e-08
Identities = 58/206 (28%), Positives = 95/206 (46%), Gaps = 23/206 (11%)
Query: 8 AQVEVVELTNDGNGLGFNL------VGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVG 61
A ++ +EL GLGF++ + ST ++I+ ++PGG+A+KD RL GD ++ V
Sbjct: 700 AGIQHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVN 759
Query: 62 SVNLRGFTSEQVAAVLRQA-GPVVRLLVAR--PADPATALRAPQPGTALVPTKI-----L 113
VNL + E+ L+ A VR+ VA+ P P + + + L P L
Sbjct: 760 DVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSPEEGYVSAKEDSFLYPPHSCEEAGL 819
Query: 114 ADPELL--DRHLIETGYGAVYDLSQCYSDYN-INGQNGETETSIVAAAVSVIGDN---PQ 167
AD L D L+ T + D S S Y+ N T+ SI++ S GD
Sbjct: 820 ADKPLFRADLALVGTNDADLVDESTFESPYSPENDSIYSTQASILSLHGSSCGDGLNYGS 879
Query: 168 KIPDHP---IVCDSVSPTITITVPVE 190
+P P ++ +S P + + + +E
Sbjct: 880 SLPSSPPKDVIENSCDPVLDLHMSLE 905
Score = 57.2 bits (132), Expect = 2e-07
Identities = 63/278 (22%), Positives = 119/278 (42%), Gaps = 26/278 (9%)
Query: 377 EIGSDKEILVAEIKKLEG-LGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAG 435
++ S K + E+ K +G LGI++ + G I+S+ G G L G
Sbjct: 1478 DLSSFKNVQHLELPKDQGGLGIAISEEDTLSGV-------IIKSLTEHGVAATDGRLKVG 1530
Query: 436 DELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARK 495
D++L V++ + G + +++LK V+L + DS P A+ E
Sbjct: 1531 DQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGE------ 1584
Query: 496 IISGSLNNLTTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVML 555
N+ +L+ QS + ++ N S S + + + E + +
Sbjct: 1585 ----KKNSSQSLMVPQS----GSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEI 1636
Query: 556 VKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNAT 615
K GLG SI+ D + I++ + G A K+G + GD+++ VNG+ ++ AT
Sbjct: 1637 SKGRTGLGLSIVGGSDTLLG---AIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKAT 1693
Query: 616 LDQAVQALKGAPRGTVKVGIARPLPPQDSSKSKGTINV 653
D+A+ L+ P+ V++ + R P + T+ +
Sbjct: 1694 HDEAINVLRQTPQ-RVRLTLYRDEAPYKEEEVCDTLTI 1730
Score = 52.4 bits (120), Expect = 5e-06
Identities = 28/85 (32%), Positives = 46/85 (54%), Gaps = 5/85 (5%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDHVLQVGSV 63
Q + + L +GLGF++VGG + + +K V G A +D RL+ GD ++ V
Sbjct: 1959 QCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQ 2018
Query: 64 NLRGFTSEQVAAVLRQAGPVVRLLV 88
+L G T E+ A+L++ V L+V
Sbjct: 2019 SLEGVTHEEAVAILKRTKGTVTLMV 2043
Score = 52.0 bits (119), Expect = 6e-06
Identities = 43/170 (25%), Positives = 82/170 (48%), Gaps = 17/170 (10%)
Query: 463 DRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTSSTA 522
DR+ +C ++ VNL + G ++++G +++ + Q + + ++ S
Sbjct: 1886 DRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGG--DVSVVTGHQQEPASSSLSFT 1943
Query: 523 TLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTV-IV 581
LT+ S +C S + L + GLGFSI+ P+G + I
Sbjct: 1944 GLTSSSIFQDDLGPPQCKS-----------ITLERGPDGLGFSIVGGYG--SPHGDLPIY 1990
Query: 582 VRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTV 631
V+++ G A ++G + GD++++VNG S++ T ++AV LK +GTV
Sbjct: 1991 VKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILK-RTKGTV 2039
Score = 50.4 bits (115), Expect = 2e-05
Identities = 28/76 (36%), Positives = 45/76 (59%), Gaps = 1/76 (1%)
Query: 207 GLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADK-SNPQSV 265
GLG +V G E GIFV+ I EGS A + G++K D+I+ ++G +L ++ Q++
Sbjct: 151 GLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAI 210
Query: 266 EILRNTGISVHLVLER 281
IL+ +V LV+ R
Sbjct: 211 SILQKAKDTVQLVIAR 226
Score = 50.4 bits (115), Expect = 2e-05
Identities = 39/122 (31%), Positives = 61/122 (50%), Gaps = 12/122 (9%)
Query: 163 GDNPQKIPDHPIVCDSVSPTITITV---PVELPEIEIIHVDLNKNVYGLGITVAGYVCEK 219
G PQ + PIV S S TI+ PV +E I +L + GLG + G
Sbjct: 227 GSLPQLVS--PIVSRSPSAASTISAHSNPVHWQHMETI--ELVNDGSGLGFGIIG----- 277
Query: 220 EELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
+ +G+ VK+I+ G A+Q G++ D I+++ LA S+ Q ++LR G V L++
Sbjct: 278 GKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMI 337
Query: 280 ER 281
R
Sbjct: 338 AR 339
Score = 50.4 bits (115), Expect = 2e-05
Identities = 31/110 (28%), Positives = 53/110 (48%), Gaps = 8/110 (7%)
Query: 528 SEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVP 587
S + ++ S WQ E I LV GLGF I + T ++V++++P
Sbjct: 238 SRSPSAASTISAHSNPVHWQHMETIE-LVNDGSGLGFGI------IGGKATGVIVKTILP 290
Query: 588 GGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIAR 637
GGVA+++G + GD ++ + + + +Q Q L+ VK+ IAR
Sbjct: 291 GGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQC-GNRVKLMIAR 339
Score = 50.4 bits (115), Expect = 2e-05
Identities = 27/94 (28%), Positives = 52/94 (55%), Gaps = 1/94 (1%)
Query: 177 DSVSPTITITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSG-IFVKSIIEGSS 235
D+ T + P+ + E I H++L K GLG ++ Y + S I ++S++ G
Sbjct: 683 DAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGI 742
Query: 236 AEQSGKIKINDRIIEVDGISLADKSNPQSVEILR 269
AE+ G++ DR++ V+ ++L + S ++VE L+
Sbjct: 743 AEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALK 776
Score = 50.4 bits (115), Expect = 2e-05
Identities = 31/91 (34%), Positives = 50/91 (54%), Gaps = 7/91 (7%)
Query: 557 KADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATL 616
K +GLG SI+ + N T + V +V GG+A+ +G + GD+++ VNG ++NAT
Sbjct: 1735 KPGKGLGLSIVGKR-----NDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNAT- 1788
Query: 617 DQAVQALKGAPRGTVKVGIARPLPPQDSSKS 647
+AV AL G++ PL +S+S
Sbjct: 1789 QEAVAALLKVSEGSLS-SFTFPLSGSSTSES 1818
Score = 50.0 bits (114), Expect = 3e-05
Identities = 67/297 (22%), Positives = 129/297 (43%), Gaps = 29/297 (9%)
Query: 5 TEWAQVEVVELTND-GNGLGFNLVGGRSTG-----------VVIKYVLPGGVADKDRRLQ 52
+ W Q VEL + LG ++VGGR G + IK+VL A K+ L+
Sbjct: 1148 SNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLK 1207
Query: 53 SGDHVLQVGSVNLRGFTSEQVAAVLRQAG-PV---VRLLVARP--ADPATALRAPQPGTA 106
GD +++V ++LR + EQ +R+AG PV V+ ++ RP + + L P
Sbjct: 1208 PGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYN 1267
Query: 107 LVPTKILADPELLDRHLIETGYGAVYDLSQ-CYSDYNINGQNGETETSIVAAAVSVIGDN 165
T AD ++ + + + + C E + ++ S I +
Sbjct: 1268 FSSTNPFADSLQINADKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQD 1327
Query: 166 PQKIPDHPIVCDSVSPTI-TITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSG 224
K + ++ T+T + + E+E H L G+++AG ++ +S
Sbjct: 1328 VDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGL-------GLSLAGNK-DRSRMS- 1378
Query: 225 IFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
+F+ I +A + G+++I D ++E++G L +S+ + I++ V ++ R
Sbjct: 1379 VFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIR 1435
Score = 50.0 bits (114), Expect = 3e-05
Identities = 28/104 (26%), Positives = 54/104 (51%), Gaps = 4/104 (3%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTGVVIKYVL---PGGVADKDRRLQSGDHVLQVGSVNL 65
++ ++EL +GLG +L G + + +++ P G A KD RLQ D +L++ L
Sbjct: 1351 ELHMIELEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQIL 1410
Query: 66 RGFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVP 109
G + + +++++ A V+++ R D + A PG A+ P
Sbjct: 1411 YGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQM-AVCPGNAVEP 1453
Score = 50.0 bits (114), Expect = 3e-05
Identities = 29/101 (28%), Positives = 57/101 (56%), Gaps = 6/101 (5%)
Query: 181 PTITIT-VPVELPEIEII-HVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQ 238
PT+T + V+L + + H++L K+ GLGI ++ E++ LSG+ +KS+ E A
Sbjct: 1468 PTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAIS----EEDTLSGVIIKSLTEHGVAAT 1523
Query: 239 SGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
G++K+ D+I+ VD + + + +L+ ++V L +
Sbjct: 1524 DGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTI 1564
Score = 48.8 bits (111), Expect = 6e-05
Identities = 36/125 (28%), Positives = 58/125 (46%), Gaps = 5/125 (4%)
Query: 503 NLTTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDI-VMLVKADQG 561
N L+ A+ T+ TA S + L + + E V L K QG
Sbjct: 331 NRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQKGEESETFDVELTKNVQG 390
Query: 562 LGFSILDY--QDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQA 619
LG +I Y ++P+G I V+S+ E +G I GD++++V+G ++Q T QA
Sbjct: 391 LGITIAGYIGDKKLEPSG--IFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQA 448
Query: 620 VQALK 624
V+ L+
Sbjct: 449 VEVLR 453
Score = 47.6 bits (108), Expect = 1e-04
Identities = 30/106 (28%), Positives = 54/106 (50%), Gaps = 4/106 (3%)
Query: 178 SVSPTITITVPVELPEIEIIH--VDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSS 235
S +P I + P P I ++++K GLG+++ G L I + + E +
Sbjct: 1611 SSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGG--SDTLLGAIIIHEVYEEGA 1668
Query: 236 AEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
A + G++ D+I+EV+GI L ++ +++ +LR T V L L R
Sbjct: 1669 ACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYR 1714
Score = 47.2 bits (107), Expect = 2e-04
Identities = 20/64 (31%), Positives = 39/64 (60%)
Query: 417 IRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDS 476
++++LP G G L +GD +L++ + L G++ +V +L+Q +RV+L+ AR +I+
Sbjct: 285 VKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARGAIEE 344
Query: 477 GPRP 480
P
Sbjct: 345 RTAP 348
Score = 46.4 bits (105), Expect = 3e-04
Identities = 35/138 (25%), Positives = 69/138 (50%), Gaps = 3/138 (2%)
Query: 143 INGQNGETETSIVAAA-VSVIGDNPQKIPDHPIVCDSVSPTITITVPVELPEIEIIHVDL 201
+ +G E +VA VSV+ + Q+ + ++ + + P+ + I ++
Sbjct: 1908 LKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKSITLER 1967
Query: 202 NKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSN 261
+ G I V GY +L I+VK++ +A + G++K D+II V+G SL ++
Sbjct: 1968 GPDGLGFSI-VGGYGSPHGDLP-IYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTH 2025
Query: 262 PQSVEILRNTGISVHLVL 279
++V IL+ T +V L++
Sbjct: 2026 EEAVAILKRTKGTVTLMV 2043
Score = 46.0 bits (104), Expect = 4e-04
Identities = 31/107 (28%), Positives = 58/107 (54%), Gaps = 5/107 (4%)
Query: 538 ECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTV-IVVRSLVPGGVAEKNGE 596
+ + +A + E +L GLGFS++ + + G + I V+ + G VA ++G
Sbjct: 128 QLIKNMAQGRHVEVFELLKPPSGGLGFSVVGLRS--ENRGELGIFVQEIQEGSVAHRDGR 185
Query: 597 ISPGDRVMSVNGVSI-QNATLDQAVQALKGAPRGTVKVGIARPLPPQ 642
+ D+++++NG ++ Q T QA+ L+ A + TV++ IAR PQ
Sbjct: 186 LKETDQILAINGQALDQTITHQQAISILQKA-KDTVQLVIARGSLPQ 231
Score = 44.0 bits (99), Expect = 0.002
Identities = 27/85 (31%), Positives = 46/85 (54%), Gaps = 1/85 (1%)
Query: 5 TEWAQVEVVELTNDGNGLGFNLVGGRS-TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSV 63
+ + V+ +EL D GLG + + +GV+IK + GVA D RL+ GD +L V
Sbjct: 1480 SSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDE 1539
Query: 64 NLRGFTSEQVAAVLRQAGPVVRLLV 88
+ G+ E+ ++L+ A V+L +
Sbjct: 1540 IVVGYPIEKFISLLKTAKMTVKLTI 1564
Score = 43.6 bits (98), Expect = 0.002
Identities = 27/76 (35%), Positives = 38/76 (50%), Gaps = 3/76 (3%)
Query: 393 EGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHS 452
+GLG S+ G G P Y+++V G G L GD+++ VN L G+TH
Sbjct: 1970 DGLGFSIVGGYGSPHGD--LPI-YVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHE 2026
Query: 453 EVVNILKQLPDRVRLV 468
E V ILK+ V L+
Sbjct: 2027 EAVAILKRTKGTVTLM 2042
Score = 42.3 bits (95), Expect = 0.005
Identities = 29/97 (29%), Positives = 50/97 (51%), Gaps = 6/97 (6%)
Query: 529 EQSKKSRSLECVS-GLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVP 587
EQS + + ECV +S E + + K + LG ++ +D G ++VRS++
Sbjct: 988 EQSSLACNAECVMLQNVSKESFERTINIAKGNSSLGMTVSANKD-----GLGMIVRSIIH 1042
Query: 588 GGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
GG ++G I+ GD ++S+N S + T QA L+
Sbjct: 1043 GGAISRDGRIAIGDCILSINEESTISVTNAQARAMLR 1079
Score = 37.9 bits (84), Expect = 0.11
Identities = 27/91 (29%), Positives = 45/91 (49%), Gaps = 4/91 (4%)
Query: 394 GLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRL-HGLTHS 452
GLG S+ G G EL +++ + G L D++L +N L +TH
Sbjct: 151 GLGFSVVGLRSENRG-ELGI--FVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQ 207
Query: 453 EVVNILKQLPDRVRLVCARNSIDSGPRPVVN 483
+ ++IL++ D V+LV AR S+ P+V+
Sbjct: 208 QAISILQKAKDTVQLVIARGSLPQLVSPIVS 238
Score = 37.5 bits (83), Expect = 0.15
Identities = 31/137 (22%), Positives = 58/137 (42%), Gaps = 4/137 (2%)
Query: 199 VDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLAD 258
+++ K LG+TV+ K+ L G+ V+SII G + + G+I I D I+ ++ S
Sbjct: 1013 INIAKGNSSLGMTVSA---NKDGL-GMIVRSIIHGGAISRDGRIAIGDCILSINEESTIS 1068
Query: 259 KSNPQSVEILRNTGISVHLVLERYLRGPKFEHLQLAIFNEERXXXXXXXXXXLSWFPVPS 318
+N Q+ +LR + + Y+ E ++++ + + +P
Sbjct: 1069 VTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDIPE 1128
Query: 319 QLENSITEIEPEPESNT 335
E E E NT
Sbjct: 1129 LPEREEGEGEESELQNT 1145
Score = 37.5 bits (83), Expect = 0.15
Identities = 36/125 (28%), Positives = 59/125 (47%), Gaps = 8/125 (6%)
Query: 516 INTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQG----LGFSILDYQD 571
++ S ++ T S S SLE S S+ + V+ +G LG SI
Sbjct: 1798 VSEGSLSSFTFPLSGSSTSESLESSSKKNALASEIQGLRTVEMKKGPTDSLGISIAGGVG 1857
Query: 572 PVDPNGTV-IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGT 630
P G V I + + P GVA + ++ GDR++++ G S + T QAV LK A G+
Sbjct: 1858 --SPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNA-SGS 1914
Query: 631 VKVGI 635
+++ +
Sbjct: 1915 IEMQV 1919
Score = 35.9 bits (79), Expect = 0.45
Identities = 23/80 (28%), Positives = 35/80 (43%), Gaps = 3/80 (3%)
Query: 17 NDGNGLGFNLVGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAV 76
N G G+ G I+ VLP G +L SGD +L+V + L G + V +
Sbjct: 566 NSGLGISLEATVGHH---FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNI 622
Query: 77 LRQAGPVVRLLVARPADPAT 96
L++ V ++ R P T
Sbjct: 623 LKELPIEVTMVCCRRTVPPT 642
Score = 33.9 bits (74), Expect = 1.8
Identities = 23/97 (23%), Positives = 45/97 (46%), Gaps = 6/97 (6%)
Query: 3 LSTEWAQVEVVELTNDG-NGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDH 56
L++E + VE+ + LG ++ GG + + I + P GVA + ++L+ GD
Sbjct: 1828 LASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDR 1887
Query: 57 VLQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVARPAD 93
++ + + G T Q +L+ A + + V D
Sbjct: 1888 IVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGD 1924
Score = 32.7 bits (71), Expect = 4.2
Identities = 23/82 (28%), Positives = 37/82 (45%), Gaps = 5/82 (6%)
Query: 388 EIKK--LEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYR 445
E+KK + LGIS+ G V G +I + P G L GD ++ +
Sbjct: 1839 EMKKGPTDSLGISIAGGVGSPLGDV---PIFIAMMHPTGVAAQTQKLRVGDRIVTICGTS 1895
Query: 446 LHGLTHSEVVNILKQLPDRVRL 467
G+TH++ VN+LK + +
Sbjct: 1896 TEGMTHTQAVNLLKNASGSIEM 1917
>AL590374-4|CAH70420.1| 1801|Homo sapiens InaD-like (Drosophila)
protein.
Length = 1801
Score = 126 bits (303), Expect = 3e-28
Identities = 99/316 (31%), Positives = 152/316 (48%), Gaps = 25/316 (7%)
Query: 178 SVSPTITITVPVELPEI------------EIIHVDL-NKNVYGLGITVAGYVCEKE--EL 222
SV+P +PV LP + E +V+L K+ LGI + GYV E
Sbjct: 333 SVTPPAPAALPVALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEA 392
Query: 223 SGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLERY 282
SGI+VKSII GS+A +G I++ND+I+ VDG+++ +N VE+LRN G VHL L R
Sbjct: 393 SGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRR 452
Query: 283 LRGPKFEHLQLAIFNEERXXXXXXXXXXLSW-FPVPSQLENSITEIEPEPESNTTIDSSV 341
L+ L+ + ++ EI+ ++ +
Sbjct: 453 KTSSSTSPLEPPSDRGTVVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQA 512
Query: 342 LE-VGDLQEPTQEELDQRFDEILAVDKEDIVKKWKEEIGSDKEI-LVAEIKKLEGLGISL 399
LE + + + + EL R++ +L D E +V +I D E+ +++ + L + +
Sbjct: 513 LEKLEKVPDSPENELKSRWENLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGV 572
Query: 400 EGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILK 459
E VD G HHYI S++ GPV G+L DELLEVN +L+G + E V+ LK
Sbjct: 573 E--VDSFDG-----HHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLK 625
Query: 460 QLPDRVRLVCARNSID 475
++P LVC R D
Sbjct: 626 EVPPPFTLVCCRRLFD 641
Score = 125 bits (302), Expect = 4e-28
Identities = 57/106 (53%), Positives = 78/106 (73%), Gaps = 2/106 (1%)
Query: 7 WAQVEVVELTNDGNGLGFNLVGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLR 66
W VE VEL NDG+GLGF +VGG+++GVV++ ++PGG+AD+D RLQ+GDH+L++G N++
Sbjct: 243 WGHVEEVELINDGSGLGFGIVGGKTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQ 302
Query: 67 GFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVPTKI 112
G TSEQVA VLR G VR+LVAR DPA + P A +P +
Sbjct: 303 GMTSEQVAQVLRNCGNSVRMLVAR--DPAGDISVTPPAPAALPVAL 346
Score = 114 bits (274), Expect = 1e-24
Identities = 55/105 (52%), Positives = 74/105 (70%)
Query: 543 LAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDR 602
LA+W + IV LVK +GLGFSILDYQDP+DP +VIV+RSLV GVAE++G + PGDR
Sbjct: 677 LALWSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDR 736
Query: 603 VMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPLPPQDSSKS 647
++SVN + N +L +AV+ LK P G V +GI +PL + +S
Sbjct: 737 LVSVNEYCLDNTSLAEAVEILKAVPPGLVHLGICKPLVEDNEEES 781
Score = 89.4 bits (212), Expect = 3e-17
Identities = 72/275 (26%), Positives = 127/275 (46%), Gaps = 29/275 (10%)
Query: 198 HVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLA 257
+V L ++ G G TV + EEL GIF+K ++E S A ++ +K D+I+EV G+ L
Sbjct: 1076 NVSLGISIVG-GQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQ 1134
Query: 258 DKSNPQSVEILRNTGISVHLVLERYLRGPKFEHLQLAIFNEERXXXXXXXXXXLSWFPVP 317
+ S+ ++VE ++N G V +++ P+ I N
Sbjct: 1135 NASHSEAVEAIKNAGNPVVFIVQSLSSTPR------VIPNVHNKANKITGN--------- 1179
Query: 318 SQLENSITEIEPEPESNTTIDSSVLEVGDLQEPTQEELDQRFDEILAVDKEDIVKKWKEE 377
+N T+ + E T +++ + ++ D+ +E D++ +++ +
Sbjct: 1180 ---QNQDTQEKKEKRQGTA--PPPMKLPPPYKALTDDSDENEEEDAFTDQK--IRQRYAD 1232
Query: 378 IGSDKEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDE 437
+ + I+ E K GLG+SL G D R ++ + P+GP G + GDE
Sbjct: 1233 LPGELHIIELE-KDKNGLGLSLAGNKD-----RSRMSIFVVGINPEGPAAADGRMRIGDE 1286
Query: 438 LLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARN 472
LLE+N L+G +H I+K P +V+LV RN
Sbjct: 1287 LLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRN 1321
Score = 72.5 bits (170), Expect = 4e-12
Identities = 64/287 (22%), Positives = 134/287 (46%), Gaps = 18/287 (6%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTGVVIKYVL---PGGVADKDRRLQSGDHVLQVGSVNL 65
++ ++EL D NGLG +L G + + +V+ P G A D R++ GD +L++ + L
Sbjct: 1236 ELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQIL 1295
Query: 66 RGFTSEQVAAVLRQAGPVVRLLVARPADPATALRA---PQPGTALVPTKILADPELLDRH 122
G + + +A+++ A V+L+ R D + P P ++ + + E +
Sbjct: 1296 YGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSE 1355
Query: 123 ---LIETGYGAVYDLSQC-YSDYNINGQNGETETSIVAAAVSVIGDNPQKIPDHPIV-CD 177
+E G + + + + Q T+ S + + + + D
Sbjct: 1356 EDGSVEVGIKQLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYG 1415
Query: 178 SVSPTITI---TVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGS 234
+++ T P+ +P E+I ++++K GLG+++ G + L+ I + + E
Sbjct: 1416 GFQAPLSVDPATCPI-VPGQEMI-IEISKGRSGLGLSIVGG--KDTPLNAIVIHEVYEEG 1471
Query: 235 SAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
+A + G++ D+I+EV+G+ L + S+ +++ LR T V LV+ R
Sbjct: 1472 AAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYR 1518
Score = 71.3 bits (167), Expect = 1e-11
Identities = 80/291 (27%), Positives = 126/291 (43%), Gaps = 37/291 (12%)
Query: 13 VELTN-DGNGLGFNLVG-------GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
VEL DG LG +VG G ++G+ +K ++PG A + +Q D ++ V VN
Sbjct: 366 VELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVN 425
Query: 65 LRGFTSEQVAAVLRQAGPVVRL-LVARPADPATA-LRAPQP-GTALVPTKILADPELLDR 121
++GF + V VLR AG VV L LV R +T+ L P GT + P K P L
Sbjct: 426 IQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLK---PPALFLT 482
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIG--DNPQKIPDHP------ 173
+ET + N++G++ E + I I + +K+PD P
Sbjct: 483 GAVET-------------ETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKS 529
Query: 174 IVCDSVSPTITITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSG-IFVKSIIE 232
+ + P + V +I +L K L I E + G ++ SI+
Sbjct: 530 RWENLLGPDYEVMVATLDTQI-ADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVS 588
Query: 233 GSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLERYL 283
G + G ++ D ++EV+G+ L KS ++V L+ LV R L
Sbjct: 589 GGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRL 639
Score = 59.3 bits (137), Expect = 4e-08
Identities = 65/245 (26%), Positives = 109/245 (44%), Gaps = 24/245 (9%)
Query: 395 LGISLEGTVDV----EGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLT 450
LGIS+ G V + G+EL+ +I+ VL D P G L GD++LEV+ L +
Sbjct: 1079 LGISIVGGQTVIKRLKNGEELKGI-FIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNAS 1137
Query: 451 HSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKA 510
HSE V +K + V + S+ S PR + N+ + +A K I+G+ N T K
Sbjct: 1138 HSEAVEAIKNAGNPVVFIV--QSLSSTPRVIPNVHN-----KANK-ITGNQNQDTQEKKE 1189
Query: 511 QSDTSINTSST-----ATLTNHSEQSKKSRSL---ECVSGLAMWQSKEDIVMLVKADQGL 562
+ + LT+ S+++++ + + A + I+ L K GL
Sbjct: 1190 KRQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGL 1249
Query: 563 GFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQA 622
G S+ + D + I V + P G A +G + GD ++ +N + + A
Sbjct: 1250 GLSLAGNK---DRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAI 1306
Query: 623 LKGAP 627
+K AP
Sbjct: 1307 IKTAP 1311
Score = 57.6 bits (133), Expect = 1e-07
Identities = 30/73 (41%), Positives = 45/73 (61%), Gaps = 1/73 (1%)
Query: 19 GNGLGFNLVGGRS-TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAVL 77
G GLG ++VG R+ +GV I ++ GG AD D RL GD +L V ++R + E VA +L
Sbjct: 1541 GRGLGLSIVGKRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATIL 1600
Query: 78 RQAGPVVRLLVAR 90
+ A +V+L + R
Sbjct: 1601 KCAQGLVQLEIGR 1613
Score = 55.2 bits (127), Expect = 7e-07
Identities = 30/92 (32%), Positives = 52/92 (56%), Gaps = 8/92 (8%)
Query: 546 WQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMS 605
W E+ V L+ GLGF I V + +VVR++VPGG+A+++G + GD ++
Sbjct: 243 WGHVEE-VELINDGSGLGFGI------VGGKTSGVVVRTIVPGGLADRDGRLQTGDHILK 295
Query: 606 VNGVSIQNATLDQAVQALKGAPRGTVKVGIAR 637
+ G ++Q T +Q Q L+ +V++ +AR
Sbjct: 296 IGGTNVQGMTSEQVAQVLRNC-GNSVRMLVAR 326
Score = 52.4 bits (120), Expect = 5e-06
Identities = 31/89 (34%), Positives = 51/89 (57%), Gaps = 7/89 (7%)
Query: 9 QVEVVELTNDGNG-LGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDHVLQVGS 62
Q+E +++ G LGF++V RS + +K V PG VAD+D+RL+ D +L +
Sbjct: 131 QIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINH 190
Query: 63 VNL-RGFTSEQVAAVLRQAGPVVRLLVAR 90
L + + +Q A+L+Q +RL+VAR
Sbjct: 191 TPLDQNISHQQAIALLQQTTGSLRLIVAR 219
Score = 51.6 bits (118), Expect = 9e-06
Identities = 29/81 (35%), Positives = 49/81 (60%), Gaps = 6/81 (7%)
Query: 557 KADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATL 616
KA +GLG SI+ + NG+ + + +V GG A+ +G + GD+++SVNG ++NA+
Sbjct: 1539 KAGRGLGLSIVGKR-----NGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQ 1593
Query: 617 DQAVQALKGAPRGTVKVGIAR 637
+ LK A +G V++ I R
Sbjct: 1594 ETVATILKCA-QGLVQLEIGR 1613
Score = 50.8 bits (116), Expect = 1e-05
Identities = 26/81 (32%), Positives = 50/81 (61%), Gaps = 5/81 (6%)
Query: 549 KEDIVMLVKADQGLGFSILDYQD-PVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVN 607
+E I+ + K GLG SI+ +D P++ IV+ + G A ++G + GD+++ VN
Sbjct: 1434 QEMIIEISKGRSGLGLSIVGGKDTPLN----AIVIHEVYEEGAAARDGRLWAGDQILEVN 1489
Query: 608 GVSIQNATLDQAVQALKGAPR 628
GV ++N++ ++A+ AL+ P+
Sbjct: 1490 GVDLRNSSHEEAITALRQTPQ 1510
Score = 50.4 bits (115), Expect = 2e-05
Identities = 31/91 (34%), Positives = 46/91 (50%), Gaps = 5/91 (5%)
Query: 382 KEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEV 441
+E+++ K GLG+S+ G D + I V +G G L AGD++LEV
Sbjct: 1434 QEMIIEISKGRSGLGLSIVGGKDTPLNAIV-----IHEVYEEGAAARDGRLWAGDQILEV 1488
Query: 442 NEYRLHGLTHSEVVNILKQLPDRVRLVCARN 472
N L +H E + L+Q P +VRLV R+
Sbjct: 1489 NGVDLRNSSHEEAITALRQTPQKVRLVVYRD 1519
Score = 50.0 bits (114), Expect = 3e-05
Identities = 43/173 (24%), Positives = 75/173 (43%), Gaps = 13/173 (7%)
Query: 194 IEIIHVDLNKNV-YGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVD 252
+EI VDL K GLG+++ G K SG+F+ I++G +A+ G++ D+I+ V+
Sbjct: 1529 LEIFPVDLQKKAGRGLGLSIVG----KRNGSGVFISDIVKGGAADLDGRLIQGDQILSVN 1584
Query: 253 GISLADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHLQLAIFNEERXXXXXXXXXXLS 312
G + + S IL+ V L + R LR + + N + S
Sbjct: 1585 GEDMRNASQETVATILKCAQGLVQLEIGR-LRAGSWTSARTTSQNSQGSQQSAHSSCHPS 1643
Query: 313 WFPVPSQLENSITEIEPEPESNTTIDSSVLEVGDLQEPTQEELDQRFDEILAV 365
+ PV + L+N + + D S G EP E+++ + L +
Sbjct: 1644 FAPVITGLQNLV-------GTKRVSDPSQKNSGTDMEPRTVEINRELSDALGI 1689
Score = 49.6 bits (113), Expect = 3e-05
Identities = 26/96 (27%), Positives = 54/96 (56%), Gaps = 5/96 (5%)
Query: 186 TVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKIN 245
T+P + + V+L + GLG + G + SG+ V++I+ G A++ G+++
Sbjct: 236 TLPETVCWGHVEEVELINDGSGLGFGIVG-----GKTSGVVVRTIVPGGLADRDGRLQTG 290
Query: 246 DRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
D I+++ G ++ ++ Q ++LRN G SV +++ R
Sbjct: 291 DHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVAR 326
Score = 46.0 bits (104), Expect = 4e-04
Identities = 27/76 (35%), Positives = 41/76 (53%), Gaps = 2/76 (2%)
Query: 553 VMLVKAD-QGLGFSILDYQDPVDPN-GTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVS 610
V LV+ D Q LG I+ Y + I V+S++PG A NG I D++++V+GV+
Sbjct: 366 VELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVN 425
Query: 611 IQNATLDQAVQALKGA 626
IQ V+ L+ A
Sbjct: 426 IQGFANHDVVEVLRNA 441
Score = 45.6 bits (103), Expect = 6e-04
Identities = 35/111 (31%), Positives = 50/111 (45%), Gaps = 7/111 (6%)
Query: 352 QEELDQRFDEILAVDKEDIVKKWKEEIGSDKEILVAEIKKLEGLGISLEGTVDVEGGQEL 411
+ E+D D D + + W E+ +V +K +GLG S+ D
Sbjct: 658 ETEVDHNMDVNTEEDDDGELALWSPEVK-----IVELVKDCKGLGFSILDYQDPL--DPT 710
Query: 412 RPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP 462
R IRS++ DG G L GD L+ VNEY L + +E V ILK +P
Sbjct: 711 RSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAVP 761
Score = 44.4 bits (100), Expect = 0.001
Identities = 58/257 (22%), Positives = 99/257 (38%), Gaps = 24/257 (9%)
Query: 393 EGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHS 452
+ LGI + G V E Y++S++P G + D+++ V+ + G +
Sbjct: 374 QSLGIRIVGYVGTSHTGEASGI-YVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANH 432
Query: 453 EVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARK----IISGSLNNLTTL- 507
+VV +L+ V L R S P+ + E K ++G++ T +
Sbjct: 433 DVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLKPPALFLTGAVETETNVD 492
Query: 508 -----VKAQSDTSINTSSTA-----TLTNHSEQSKKSR-------SLECVSGLAMWQSKE 550
+K + DT N + A + + E KSR E + Q +
Sbjct: 493 GEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDYEVMVATLDTQIAD 552
Query: 551 DIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVS 610
D L K + L L VD + S+V GG + G + P D ++ VNG+
Sbjct: 553 D-AELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQ 611
Query: 611 IQNATLDQAVQALKGAP 627
+ + +AV LK P
Sbjct: 612 LYGKSRREAVSFLKEVP 628
Score = 43.6 bits (98), Expect = 0.002
Identities = 32/123 (26%), Positives = 59/123 (47%), Gaps = 6/123 (4%)
Query: 509 KAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILD 568
KA + T + +S AT T + ++ E + W + + + + LG SI+
Sbjct: 1027 KASAYTGMLSSRYATDTCELPEREEGEGEE-TPNFSHWGPPRIVEIFREPNVSLGISIVG 1085
Query: 569 YQDPVD--PNGTV---IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQAL 623
Q + NG I ++ ++ A K + GD+++ V+GV +QNA+ +AV+A+
Sbjct: 1086 GQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAI 1145
Query: 624 KGA 626
K A
Sbjct: 1146 KNA 1148
Score = 41.9 bits (94), Expect = 0.007
Identities = 25/89 (28%), Positives = 50/89 (56%), Gaps = 2/89 (2%)
Query: 195 EIIHVDLNK-NVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDG 253
+I ++D+ + + GLG +V + IFVK + GS A++ ++K ND+I+ ++
Sbjct: 131 QIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINH 190
Query: 254 ISLADK-SNPQSVEILRNTGISVHLVLER 281
L S+ Q++ +L+ T S+ L++ R
Sbjct: 191 TPLDQNISHQQAIALLQQTTGSLRLIVAR 219
Score = 41.5 bits (93), Expect = 0.009
Identities = 26/79 (32%), Positives = 46/79 (58%), Gaps = 3/79 (3%)
Query: 192 PEIEIIHVDLNKNVYGLGITVAGYVCEKEEL-SGIFVKSIIEGSSAEQSGKIKINDRIIE 250
PE++I V+L K+ GLG ++ Y + S I ++S++ AE+SG + DR++
Sbjct: 682 PEVKI--VELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVS 739
Query: 251 VDGISLADKSNPQSVEILR 269
V+ L + S ++VEIL+
Sbjct: 740 VNEYCLDNTSLAEAVEILK 758
Score = 40.3 bits (90), Expect = 0.021
Identities = 16/56 (28%), Positives = 32/56 (57%)
Query: 417 IRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARN 472
+R+++P G G L GD +L++ + G+T +V +L+ + VR++ AR+
Sbjct: 272 VRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARD 327
Score = 39.1 bits (87), Expect = 0.049
Identities = 32/111 (28%), Positives = 52/111 (46%), Gaps = 6/111 (5%)
Query: 379 GSDKEILVAEIKK--LEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGD 436
G+D E EI + + LGIS+ G G +I + G L GD
Sbjct: 1669 GTDMEPRTVEINRELSDALGISIAGG---RGSPLGDIPVFIAMIQASGVAARTQKLKVGD 1725
Query: 437 ELLEVNEYRLHGLTHSEVVNILKQLPDRVRL-VCARNSIDSGPRPVVNLAS 486
++ +N L GL+H++VVN+LK R+ L V A +I + + N+++
Sbjct: 1726 RIVSINGQPLDGLSHADVVNLLKNAYGRIILQVVADTNISAIAAQLENMST 1776
Score = 38.3 bits (85), Expect = 0.085
Identities = 25/93 (26%), Positives = 49/93 (52%), Gaps = 8/93 (8%)
Query: 7 WA-QVEVVELTNDGNGLGFNLVGGRS------TGVVIKYVLPGGVADKDRRLQSGDHVLQ 59
W+ +V++VEL D GLGF+++ + + +VI+ ++ GVA++ L GD ++
Sbjct: 680 WSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVS 739
Query: 60 VGSVNLRGFTSEQVAAVLRQAGP-VVRLLVARP 91
V L + + +L+ P +V L + +P
Sbjct: 740 VNEYCLDNTSLAEAVEILKAVPPGLVHLGICKP 772
Score = 37.1 bits (82), Expect = 0.20
Identities = 53/245 (21%), Positives = 94/245 (38%), Gaps = 25/245 (10%)
Query: 383 EILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVN 442
EI +++K G G+ L V G + +I ++ G L G L GD++L VN
Sbjct: 1530 EIFPVDLQKKAGRGLGLS-IVGKRNGSGV----FISDIVKGGAADLDGRLIQGDQILSVN 1584
Query: 443 EYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLN 502
+ + V ILK V+L R + +G S + S
Sbjct: 1585 GEDMRNASQETVATILKCAQGLVQLEIGR--LRAGSWTSARTTSQNSQGSQQSAHSSCHP 1642
Query: 503 NLTTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGL 562
+ ++ N T +++ S+++ SG M + + + L
Sbjct: 1643 SFAPVITGLQ----NLVGTKRVSDPSQKN---------SGTDM--EPRTVEINRELSDAL 1687
Query: 563 GFSILDYQDPVDPNGTV-IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQ 621
G SI + P G + + + + GVA + ++ GDR++S+NG + + V
Sbjct: 1688 GISIAGGRG--SPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVN 1745
Query: 622 ALKGA 626
LK A
Sbjct: 1746 LLKNA 1750
Score = 35.5 bits (78), Expect = 0.60
Identities = 21/73 (28%), Positives = 39/73 (53%), Gaps = 1/73 (1%)
Query: 199 VDLNKNVY-GLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLA 257
V++N+ + LGI++AG +F+ I A ++ K+K+ DRI+ ++G L
Sbjct: 1677 VEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLD 1736
Query: 258 DKSNPQSVEILRN 270
S+ V +L+N
Sbjct: 1737 GLSHADVVNLLKN 1749
Score = 34.7 bits (76), Expect = 1.0
Identities = 23/84 (27%), Positives = 43/84 (51%), Gaps = 7/84 (8%)
Query: 13 VELTND-GNGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLR 66
VE+ + + LG ++ GGR + V I + GVA + ++L+ GD ++ + L
Sbjct: 1677 VEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLD 1736
Query: 67 GFTSEQVAAVLRQA-GPVVRLLVA 89
G + V +L+ A G ++ +VA
Sbjct: 1737 GLSHADVVNLLKNAYGRIILQVVA 1760
>AL590374-3|CAH70418.1| 1582|Homo sapiens InaD-like (Drosophila)
protein.
Length = 1582
Score = 126 bits (303), Expect = 3e-28
Identities = 99/316 (31%), Positives = 152/316 (48%), Gaps = 25/316 (7%)
Query: 178 SVSPTITITVPVELPEI------------EIIHVDL-NKNVYGLGITVAGYVCEKE--EL 222
SV+P +PV LP + E +V+L K+ LGI + GYV E
Sbjct: 333 SVTPPAPAALPVALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEA 392
Query: 223 SGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLERY 282
SGI+VKSII GS+A +G I++ND+I+ VDG+++ +N VE+LRN G VHL L R
Sbjct: 393 SGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRR 452
Query: 283 LRGPKFEHLQLAIFNEERXXXXXXXXXXLSW-FPVPSQLENSITEIEPEPESNTTIDSSV 341
L+ L+ + ++ EI+ ++ +
Sbjct: 453 KTSSSTSPLEPPSDRGTVVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQA 512
Query: 342 LE-VGDLQEPTQEELDQRFDEILAVDKEDIVKKWKEEIGSDKEI-LVAEIKKLEGLGISL 399
LE + + + + EL R++ +L D E +V +I D E+ +++ + L + +
Sbjct: 513 LEKLEKVPDSPENELKSRWENLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGV 572
Query: 400 EGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILK 459
E VD G HHYI S++ GPV G+L DELLEVN +L+G + E V+ LK
Sbjct: 573 E--VDSFDG-----HHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLK 625
Query: 460 QLPDRVRLVCARNSID 475
++P LVC R D
Sbjct: 626 EVPPPFTLVCCRRLFD 641
Score = 125 bits (302), Expect = 4e-28
Identities = 57/106 (53%), Positives = 78/106 (73%), Gaps = 2/106 (1%)
Query: 7 WAQVEVVELTNDGNGLGFNLVGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLR 66
W VE VEL NDG+GLGF +VGG+++GVV++ ++PGG+AD+D RLQ+GDH+L++G N++
Sbjct: 243 WGHVEEVELINDGSGLGFGIVGGKTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQ 302
Query: 67 GFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVPTKI 112
G TSEQVA VLR G VR+LVAR DPA + P A +P +
Sbjct: 303 GMTSEQVAQVLRNCGNSVRMLVAR--DPAGDISVTPPAPAALPVAL 346
Score = 114 bits (274), Expect = 1e-24
Identities = 55/105 (52%), Positives = 74/105 (70%)
Query: 543 LAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDR 602
LA+W + IV LVK +GLGFSILDYQDP+DP +VIV+RSLV GVAE++G + PGDR
Sbjct: 677 LALWSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDR 736
Query: 603 VMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPLPPQDSSKS 647
++SVN + N +L +AV+ LK P G V +GI +PL + +S
Sbjct: 737 LVSVNEYCLDNTSLAEAVEILKAVPPGLVHLGICKPLVEDNEEES 781
Score = 89.4 bits (212), Expect = 3e-17
Identities = 72/275 (26%), Positives = 127/275 (46%), Gaps = 29/275 (10%)
Query: 198 HVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLA 257
+V L ++ G G TV + EEL GIF+K ++E S A ++ +K D+I+EV G+ L
Sbjct: 1076 NVSLGISIVG-GQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQ 1134
Query: 258 DKSNPQSVEILRNTGISVHLVLERYLRGPKFEHLQLAIFNEERXXXXXXXXXXLSWFPVP 317
+ S+ ++VE ++N G V +++ P+ I N
Sbjct: 1135 NASHSEAVEAIKNAGNPVVFIVQSLSSTPR------VIPNVHNKANKITGN--------- 1179
Query: 318 SQLENSITEIEPEPESNTTIDSSVLEVGDLQEPTQEELDQRFDEILAVDKEDIVKKWKEE 377
+N T+ + E T +++ + ++ D+ +E D++ +++ +
Sbjct: 1180 ---QNQDTQEKKEKRQGTA--PPPMKLPPPYKALTDDSDENEEEDAFTDQK--IRQRYAD 1232
Query: 378 IGSDKEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDE 437
+ + I+ E K GLG+SL G D R ++ + P+GP G + GDE
Sbjct: 1233 LPGELHIIELE-KDKNGLGLSLAGNKD-----RSRMSIFVVGINPEGPAAADGRMRIGDE 1286
Query: 438 LLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARN 472
LLE+N L+G +H I+K P +V+LV RN
Sbjct: 1287 LLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRN 1321
Score = 71.3 bits (167), Expect = 1e-11
Identities = 80/291 (27%), Positives = 126/291 (43%), Gaps = 37/291 (12%)
Query: 13 VELTN-DGNGLGFNLVG-------GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
VEL DG LG +VG G ++G+ +K ++PG A + +Q D ++ V VN
Sbjct: 366 VELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVN 425
Query: 65 LRGFTSEQVAAVLRQAGPVVRL-LVARPADPATA-LRAPQP-GTALVPTKILADPELLDR 121
++GF + V VLR AG VV L LV R +T+ L P GT + P K P L
Sbjct: 426 IQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLK---PPALFLT 482
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIG--DNPQKIPDHP------ 173
+ET + N++G++ E + I I + +K+PD P
Sbjct: 483 GAVET-------------ETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKS 529
Query: 174 IVCDSVSPTITITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSG-IFVKSIIE 232
+ + P + V +I +L K L I E + G ++ SI+
Sbjct: 530 RWENLLGPDYEVMVATLDTQI-ADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVS 588
Query: 233 GSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLERYL 283
G + G ++ D ++EV+G+ L KS ++V L+ LV R L
Sbjct: 589 GGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRL 639
Score = 59.3 bits (137), Expect = 4e-08
Identities = 65/245 (26%), Positives = 109/245 (44%), Gaps = 24/245 (9%)
Query: 395 LGISLEGTVDV----EGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLT 450
LGIS+ G V + G+EL+ +I+ VL D P G L GD++LEV+ L +
Sbjct: 1079 LGISIVGGQTVIKRLKNGEELKGI-FIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNAS 1137
Query: 451 HSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKA 510
HSE V +K + V + S+ S PR + N+ + +A K I+G+ N T K
Sbjct: 1138 HSEAVEAIKNAGNPVVFIV--QSLSSTPRVIPNVHN-----KANK-ITGNQNQDTQEKKE 1189
Query: 511 QSDTSINTSST-----ATLTNHSEQSKKSRSL---ECVSGLAMWQSKEDIVMLVKADQGL 562
+ + LT+ S+++++ + + A + I+ L K GL
Sbjct: 1190 KRQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGL 1249
Query: 563 GFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQA 622
G S+ + D + I V + P G A +G + GD ++ +N + + A
Sbjct: 1250 GLSLAGNK---DRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAI 1306
Query: 623 LKGAP 627
+K AP
Sbjct: 1307 IKTAP 1311
Score = 55.2 bits (127), Expect = 7e-07
Identities = 30/92 (32%), Positives = 52/92 (56%), Gaps = 8/92 (8%)
Query: 546 WQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMS 605
W E+ V L+ GLGF I V + +VVR++VPGG+A+++G + GD ++
Sbjct: 243 WGHVEE-VELINDGSGLGFGI------VGGKTSGVVVRTIVPGGLADRDGRLQTGDHILK 295
Query: 606 VNGVSIQNATLDQAVQALKGAPRGTVKVGIAR 637
+ G ++Q T +Q Q L+ +V++ +AR
Sbjct: 296 IGGTNVQGMTSEQVAQVLRNC-GNSVRMLVAR 326
Score = 52.4 bits (120), Expect = 5e-06
Identities = 31/89 (34%), Positives = 51/89 (57%), Gaps = 7/89 (7%)
Query: 9 QVEVVELTNDGNG-LGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDHVLQVGS 62
Q+E +++ G LGF++V RS + +K V PG VAD+D+RL+ D +L +
Sbjct: 131 QIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINH 190
Query: 63 VNL-RGFTSEQVAAVLRQAGPVVRLLVAR 90
L + + +Q A+L+Q +RL+VAR
Sbjct: 191 TPLDQNISHQQAIALLQQTTGSLRLIVAR 219
Score = 51.2 bits (117), Expect = 1e-05
Identities = 30/108 (27%), Positives = 56/108 (51%), Gaps = 4/108 (3%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTGVVIKYVL---PGGVADKDRRLQSGDHVLQVGSVNL 65
++ ++EL D NGLG +L G + + +V+ P G A D R++ GD +L++ + L
Sbjct: 1236 ELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQIL 1295
Query: 66 RGFTSEQVAAVLRQAGPVVRLLVARPADPATALR-APQPGTALVPTKI 112
G + + +A+++ A V+L+ R D + P P + P+ I
Sbjct: 1296 YGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSI 1343
Score = 49.6 bits (113), Expect = 3e-05
Identities = 26/96 (27%), Positives = 54/96 (56%), Gaps = 5/96 (5%)
Query: 186 TVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKIN 245
T+P + + V+L + GLG + G + SG+ V++I+ G A++ G+++
Sbjct: 236 TLPETVCWGHVEEVELINDGSGLGFGIVG-----GKTSGVVVRTIVPGGLADRDGRLQTG 290
Query: 246 DRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
D I+++ G ++ ++ Q ++LRN G SV +++ R
Sbjct: 291 DHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVAR 326
Score = 46.4 bits (105), Expect = 3e-04
Identities = 23/56 (41%), Positives = 31/56 (55%)
Query: 417 IRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARN 472
I V +G G L AGD++LEVN L +H E + L+Q P +VRLV R+
Sbjct: 1494 IHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRD 1549
Score = 46.0 bits (104), Expect = 4e-04
Identities = 27/76 (35%), Positives = 41/76 (53%), Gaps = 2/76 (2%)
Query: 553 VMLVKAD-QGLGFSILDYQDPVDPN-GTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVS 610
V LV+ D Q LG I+ Y + I V+S++PG A NG I D++++V+GV+
Sbjct: 366 VELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVN 425
Query: 611 IQNATLDQAVQALKGA 626
IQ V+ L+ A
Sbjct: 426 IQGFANHDVVEVLRNA 441
Score = 45.6 bits (103), Expect = 6e-04
Identities = 35/111 (31%), Positives = 50/111 (45%), Gaps = 7/111 (6%)
Query: 352 QEELDQRFDEILAVDKEDIVKKWKEEIGSDKEILVAEIKKLEGLGISLEGTVDVEGGQEL 411
+ E+D D D + + W E+ +V +K +GLG S+ D
Sbjct: 658 ETEVDHNMDVNTEEDDDGELALWSPEVK-----IVELVKDCKGLGFSILDYQDPL--DPT 710
Query: 412 RPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP 462
R IRS++ DG G L GD L+ VNEY L + +E V ILK +P
Sbjct: 711 RSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAVP 761
Score = 45.6 bits (103), Expect = 6e-04
Identities = 24/57 (42%), Positives = 33/57 (57%)
Query: 34 VVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVAR 90
+VI V G A +D RL +GD +L+V V+LR + E+ LRQ VRL+V R
Sbjct: 1492 IVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYR 1548
Score = 44.4 bits (100), Expect = 0.001
Identities = 58/257 (22%), Positives = 99/257 (38%), Gaps = 24/257 (9%)
Query: 393 EGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHS 452
+ LGI + G V E Y++S++P G + D+++ V+ + G +
Sbjct: 374 QSLGIRIVGYVGTSHTGEASGI-YVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANH 432
Query: 453 EVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARK----IISGSLNNLTTL- 507
+VV +L+ V L R S P+ + E K ++G++ T +
Sbjct: 433 DVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLKPPALFLTGAVETETNVD 492
Query: 508 -----VKAQSDTSINTSSTA-----TLTNHSEQSKKSR-------SLECVSGLAMWQSKE 550
+K + DT N + A + + E KSR E + Q +
Sbjct: 493 GEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDYEVMVATLDTQIAD 552
Query: 551 DIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVS 610
D L K + L L VD + S+V GG + G + P D ++ VNG+
Sbjct: 553 D-AELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQ 611
Query: 611 IQNATLDQAVQALKGAP 627
+ + +AV LK P
Sbjct: 612 LYGKSRREAVSFLKEVP 628
Score = 43.6 bits (98), Expect = 0.002
Identities = 32/123 (26%), Positives = 59/123 (47%), Gaps = 6/123 (4%)
Query: 509 KAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILD 568
KA + T + +S AT T + ++ E + W + + + + LG SI+
Sbjct: 1027 KASAYTGMLSSRYATDTCELPEREEGEGEE-TPNFSHWGPPRIVEIFREPNVSLGISIVG 1085
Query: 569 YQDPVD--PNGTV---IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQAL 623
Q + NG I ++ ++ A K + GD+++ V+GV +QNA+ +AV+A+
Sbjct: 1086 GQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAI 1145
Query: 624 KGA 626
K A
Sbjct: 1146 KNA 1148
Score = 43.6 bits (98), Expect = 0.002
Identities = 21/66 (31%), Positives = 38/66 (57%)
Query: 216 VCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISV 275
V E E + I + + E +A + G++ D+I+EV+G+ L + S+ +++ LR T V
Sbjct: 1483 VTEVEGQNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKV 1542
Query: 276 HLVLER 281
LV+ R
Sbjct: 1543 RLVVYR 1548
Score = 42.7 bits (96), Expect = 0.004
Identities = 16/49 (32%), Positives = 33/49 (67%)
Query: 580 IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPR 628
IV+ + G A ++G + GD+++ VNGV ++N++ ++A+ AL+ P+
Sbjct: 1492 IVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQ 1540
Score = 41.9 bits (94), Expect = 0.007
Identities = 25/89 (28%), Positives = 50/89 (56%), Gaps = 2/89 (2%)
Query: 195 EIIHVDLNK-NVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDG 253
+I ++D+ + + GLG +V + IFVK + GS A++ ++K ND+I+ ++
Sbjct: 131 QIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINH 190
Query: 254 ISLADK-SNPQSVEILRNTGISVHLVLER 281
L S+ Q++ +L+ T S+ L++ R
Sbjct: 191 TPLDQNISHQQAIALLQQTTGSLRLIVAR 219
Score = 41.5 bits (93), Expect = 0.009
Identities = 26/79 (32%), Positives = 46/79 (58%), Gaps = 3/79 (3%)
Query: 192 PEIEIIHVDLNKNVYGLGITVAGYVCEKEEL-SGIFVKSIIEGSSAEQSGKIKINDRIIE 250
PE++I V+L K+ GLG ++ Y + S I ++S++ AE+SG + DR++
Sbjct: 682 PEVKI--VELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVS 739
Query: 251 VDGISLADKSNPQSVEILR 269
V+ L + S ++VEIL+
Sbjct: 740 VNEYCLDNTSLAEAVEILK 758
Score = 40.3 bits (90), Expect = 0.021
Identities = 16/56 (28%), Positives = 32/56 (57%)
Query: 417 IRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARN 472
+R+++P G G L GD +L++ + G+T +V +L+ + VR++ AR+
Sbjct: 272 VRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARD 327
Score = 39.5 bits (88), Expect = 0.037
Identities = 25/87 (28%), Positives = 47/87 (54%), Gaps = 2/87 (2%)
Query: 195 EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGI 254
E+ ++L K+ GLG+++AG ++ +S IFV I A G+++I D ++E++
Sbjct: 1236 ELHIIELEKDKNGLGLSLAGNK-DRSRMS-IFVVGINPEGPAAADGRMRIGDELLEINNQ 1293
Query: 255 SLADKSNPQSVEILRNTGISVHLVLER 281
L +S+ + I++ V LV R
Sbjct: 1294 ILYGRSHQNASAIIKTAPSKVKLVFIR 1320
Score = 38.3 bits (85), Expect = 0.085
Identities = 25/93 (26%), Positives = 49/93 (52%), Gaps = 8/93 (8%)
Query: 7 WA-QVEVVELTNDGNGLGFNLVGGRS------TGVVIKYVLPGGVADKDRRLQSGDHVLQ 59
W+ +V++VEL D GLGF+++ + + +VI+ ++ GVA++ L GD ++
Sbjct: 680 WSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVS 739
Query: 60 VGSVNLRGFTSEQVAAVLRQAGP-VVRLLVARP 91
V L + + +L+ P +V L + +P
Sbjct: 740 VNEYCLDNTSLAEAVEILKAVPPGLVHLGICKP 772
>AL449143-2|CAI15925.1| 1801|Homo sapiens InaD-like (Drosophila)
protein.
Length = 1801
Score = 126 bits (303), Expect = 3e-28
Identities = 99/316 (31%), Positives = 152/316 (48%), Gaps = 25/316 (7%)
Query: 178 SVSPTITITVPVELPEI------------EIIHVDL-NKNVYGLGITVAGYVCEKE--EL 222
SV+P +PV LP + E +V+L K+ LGI + GYV E
Sbjct: 333 SVTPPAPAALPVALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEA 392
Query: 223 SGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLERY 282
SGI+VKSII GS+A +G I++ND+I+ VDG+++ +N VE+LRN G VHL L R
Sbjct: 393 SGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRR 452
Query: 283 LRGPKFEHLQLAIFNEERXXXXXXXXXXLSW-FPVPSQLENSITEIEPEPESNTTIDSSV 341
L+ L+ + ++ EI+ ++ +
Sbjct: 453 KTSSSTSPLEPPSDRGTVVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQA 512
Query: 342 LE-VGDLQEPTQEELDQRFDEILAVDKEDIVKKWKEEIGSDKEI-LVAEIKKLEGLGISL 399
LE + + + + EL R++ +L D E +V +I D E+ +++ + L + +
Sbjct: 513 LEKLEKVPDSPENELKSRWENLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGV 572
Query: 400 EGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILK 459
E VD G HHYI S++ GPV G+L DELLEVN +L+G + E V+ LK
Sbjct: 573 E--VDSFDG-----HHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLK 625
Query: 460 QLPDRVRLVCARNSID 475
++P LVC R D
Sbjct: 626 EVPPPFTLVCCRRLFD 641
Score = 125 bits (302), Expect = 4e-28
Identities = 57/106 (53%), Positives = 78/106 (73%), Gaps = 2/106 (1%)
Query: 7 WAQVEVVELTNDGNGLGFNLVGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLR 66
W VE VEL NDG+GLGF +VGG+++GVV++ ++PGG+AD+D RLQ+GDH+L++G N++
Sbjct: 243 WGHVEEVELINDGSGLGFGIVGGKTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQ 302
Query: 67 GFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVPTKI 112
G TSEQVA VLR G VR+LVAR DPA + P A +P +
Sbjct: 303 GMTSEQVAQVLRNCGNSVRMLVAR--DPAGDISVTPPAPAALPVAL 346
Score = 114 bits (274), Expect = 1e-24
Identities = 55/105 (52%), Positives = 74/105 (70%)
Query: 543 LAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDR 602
LA+W + IV LVK +GLGFSILDYQDP+DP +VIV+RSLV GVAE++G + PGDR
Sbjct: 677 LALWSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDR 736
Query: 603 VMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPLPPQDSSKS 647
++SVN + N +L +AV+ LK P G V +GI +PL + +S
Sbjct: 737 LVSVNEYCLDNTSLAEAVEILKAVPPGLVHLGICKPLVEDNEEES 781
Score = 89.4 bits (212), Expect = 3e-17
Identities = 72/275 (26%), Positives = 127/275 (46%), Gaps = 29/275 (10%)
Query: 198 HVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLA 257
+V L ++ G G TV + EEL GIF+K ++E S A ++ +K D+I+EV G+ L
Sbjct: 1076 NVSLGISIVG-GQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQ 1134
Query: 258 DKSNPQSVEILRNTGISVHLVLERYLRGPKFEHLQLAIFNEERXXXXXXXXXXLSWFPVP 317
+ S+ ++VE ++N G V +++ P+ I N
Sbjct: 1135 NASHSEAVEAIKNAGNPVVFIVQSLSSTPR------VIPNVHNKANKITGN--------- 1179
Query: 318 SQLENSITEIEPEPESNTTIDSSVLEVGDLQEPTQEELDQRFDEILAVDKEDIVKKWKEE 377
+N T+ + E T +++ + ++ D+ +E D++ +++ +
Sbjct: 1180 ---QNQDTQEKKEKRQGTA--PPPMKLPPPYKALTDDSDENEEEDAFTDQK--IRQRYAD 1232
Query: 378 IGSDKEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDE 437
+ + I+ E K GLG+SL G D R ++ + P+GP G + GDE
Sbjct: 1233 LPGELHIIELE-KDKNGLGLSLAGNKD-----RSRMSIFVVGINPEGPAAADGRMRIGDE 1286
Query: 438 LLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARN 472
LLE+N L+G +H I+K P +V+LV RN
Sbjct: 1287 LLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRN 1321
Score = 72.5 bits (170), Expect = 4e-12
Identities = 64/287 (22%), Positives = 134/287 (46%), Gaps = 18/287 (6%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTGVVIKYVL---PGGVADKDRRLQSGDHVLQVGSVNL 65
++ ++EL D NGLG +L G + + +V+ P G A D R++ GD +L++ + L
Sbjct: 1236 ELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQIL 1295
Query: 66 RGFTSEQVAAVLRQAGPVVRLLVARPADPATALRA---PQPGTALVPTKILADPELLDRH 122
G + + +A+++ A V+L+ R D + P P ++ + + E +
Sbjct: 1296 YGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSE 1355
Query: 123 ---LIETGYGAVYDLSQC-YSDYNINGQNGETETSIVAAAVSVIGDNPQKIPDHPIV-CD 177
+E G + + + + Q T+ S + + + + D
Sbjct: 1356 EDGSVEVGIKQLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYG 1415
Query: 178 SVSPTITI---TVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGS 234
+++ T P+ +P E+I ++++K GLG+++ G + L+ I + + E
Sbjct: 1416 GFQAPLSVDPATCPI-VPGQEMI-IEISKGRSGLGLSIVGG--KDTPLNAIVIHEVYEEG 1471
Query: 235 SAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
+A + G++ D+I+EV+G+ L + S+ +++ LR T V LV+ R
Sbjct: 1472 AAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYR 1518
Score = 71.3 bits (167), Expect = 1e-11
Identities = 80/291 (27%), Positives = 126/291 (43%), Gaps = 37/291 (12%)
Query: 13 VELTN-DGNGLGFNLVG-------GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
VEL DG LG +VG G ++G+ +K ++PG A + +Q D ++ V VN
Sbjct: 366 VELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVN 425
Query: 65 LRGFTSEQVAAVLRQAGPVVRL-LVARPADPATA-LRAPQP-GTALVPTKILADPELLDR 121
++GF + V VLR AG VV L LV R +T+ L P GT + P K P L
Sbjct: 426 IQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLK---PPALFLT 482
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIG--DNPQKIPDHP------ 173
+ET + N++G++ E + I I + +K+PD P
Sbjct: 483 GAVET-------------ETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKS 529
Query: 174 IVCDSVSPTITITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSG-IFVKSIIE 232
+ + P + V +I +L K L I E + G ++ SI+
Sbjct: 530 RWENLLGPDYEVMVATLDTQI-ADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVS 588
Query: 233 GSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLERYL 283
G + G ++ D ++EV+G+ L KS ++V L+ LV R L
Sbjct: 589 GGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRL 639
Score = 59.3 bits (137), Expect = 4e-08
Identities = 65/245 (26%), Positives = 109/245 (44%), Gaps = 24/245 (9%)
Query: 395 LGISLEGTVDV----EGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLT 450
LGIS+ G V + G+EL+ +I+ VL D P G L GD++LEV+ L +
Sbjct: 1079 LGISIVGGQTVIKRLKNGEELKGI-FIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNAS 1137
Query: 451 HSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKA 510
HSE V +K + V + S+ S PR + N+ + +A K I+G+ N T K
Sbjct: 1138 HSEAVEAIKNAGNPVVFIV--QSLSSTPRVIPNVHN-----KANK-ITGNQNQDTQEKKE 1189
Query: 511 QSDTSINTSST-----ATLTNHSEQSKKSRSL---ECVSGLAMWQSKEDIVMLVKADQGL 562
+ + LT+ S+++++ + + A + I+ L K GL
Sbjct: 1190 KRQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGL 1249
Query: 563 GFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQA 622
G S+ + D + I V + P G A +G + GD ++ +N + + A
Sbjct: 1250 GLSLAGNK---DRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAI 1306
Query: 623 LKGAP 627
+K AP
Sbjct: 1307 IKTAP 1311
Score = 57.6 bits (133), Expect = 1e-07
Identities = 30/73 (41%), Positives = 45/73 (61%), Gaps = 1/73 (1%)
Query: 19 GNGLGFNLVGGRS-TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAVL 77
G GLG ++VG R+ +GV I ++ GG AD D RL GD +L V ++R + E VA +L
Sbjct: 1541 GRGLGLSIVGKRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATIL 1600
Query: 78 RQAGPVVRLLVAR 90
+ A +V+L + R
Sbjct: 1601 KCAQGLVQLEIGR 1613
Score = 55.2 bits (127), Expect = 7e-07
Identities = 30/92 (32%), Positives = 52/92 (56%), Gaps = 8/92 (8%)
Query: 546 WQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMS 605
W E+ V L+ GLGF I V + +VVR++VPGG+A+++G + GD ++
Sbjct: 243 WGHVEE-VELINDGSGLGFGI------VGGKTSGVVVRTIVPGGLADRDGRLQTGDHILK 295
Query: 606 VNGVSIQNATLDQAVQALKGAPRGTVKVGIAR 637
+ G ++Q T +Q Q L+ +V++ +AR
Sbjct: 296 IGGTNVQGMTSEQVAQVLRNC-GNSVRMLVAR 326
Score = 52.4 bits (120), Expect = 5e-06
Identities = 31/89 (34%), Positives = 51/89 (57%), Gaps = 7/89 (7%)
Query: 9 QVEVVELTNDGNG-LGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDHVLQVGS 62
Q+E +++ G LGF++V RS + +K V PG VAD+D+RL+ D +L +
Sbjct: 131 QIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINH 190
Query: 63 VNL-RGFTSEQVAAVLRQAGPVVRLLVAR 90
L + + +Q A+L+Q +RL+VAR
Sbjct: 191 TPLDQNISHQQAIALLQQTTGSLRLIVAR 219
Score = 51.6 bits (118), Expect = 9e-06
Identities = 29/81 (35%), Positives = 49/81 (60%), Gaps = 6/81 (7%)
Query: 557 KADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATL 616
KA +GLG SI+ + NG+ + + +V GG A+ +G + GD+++SVNG ++NA+
Sbjct: 1539 KAGRGLGLSIVGKR-----NGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQ 1593
Query: 617 DQAVQALKGAPRGTVKVGIAR 637
+ LK A +G V++ I R
Sbjct: 1594 ETVATILKCA-QGLVQLEIGR 1613
Score = 50.8 bits (116), Expect = 1e-05
Identities = 26/81 (32%), Positives = 50/81 (61%), Gaps = 5/81 (6%)
Query: 549 KEDIVMLVKADQGLGFSILDYQD-PVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVN 607
+E I+ + K GLG SI+ +D P++ IV+ + G A ++G + GD+++ VN
Sbjct: 1434 QEMIIEISKGRSGLGLSIVGGKDTPLN----AIVIHEVYEEGAAARDGRLWAGDQILEVN 1489
Query: 608 GVSIQNATLDQAVQALKGAPR 628
GV ++N++ ++A+ AL+ P+
Sbjct: 1490 GVDLRNSSHEEAITALRQTPQ 1510
Score = 50.4 bits (115), Expect = 2e-05
Identities = 31/91 (34%), Positives = 46/91 (50%), Gaps = 5/91 (5%)
Query: 382 KEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEV 441
+E+++ K GLG+S+ G D + I V +G G L AGD++LEV
Sbjct: 1434 QEMIIEISKGRSGLGLSIVGGKDTPLNAIV-----IHEVYEEGAAARDGRLWAGDQILEV 1488
Query: 442 NEYRLHGLTHSEVVNILKQLPDRVRLVCARN 472
N L +H E + L+Q P +VRLV R+
Sbjct: 1489 NGVDLRNSSHEEAITALRQTPQKVRLVVYRD 1519
Score = 50.0 bits (114), Expect = 3e-05
Identities = 43/173 (24%), Positives = 75/173 (43%), Gaps = 13/173 (7%)
Query: 194 IEIIHVDLNKNV-YGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVD 252
+EI VDL K GLG+++ G K SG+F+ I++G +A+ G++ D+I+ V+
Sbjct: 1529 LEIFPVDLQKKAGRGLGLSIVG----KRNGSGVFISDIVKGGAADLDGRLIQGDQILSVN 1584
Query: 253 GISLADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHLQLAIFNEERXXXXXXXXXXLS 312
G + + S IL+ V L + R LR + + N + S
Sbjct: 1585 GEDMRNASQETVATILKCAQGLVQLEIGR-LRAGSWTSARTTSQNSQGSQQSAHSSCHPS 1643
Query: 313 WFPVPSQLENSITEIEPEPESNTTIDSSVLEVGDLQEPTQEELDQRFDEILAV 365
+ PV + L+N + + D S G EP E+++ + L +
Sbjct: 1644 FAPVITGLQNLV-------GTKRVSDPSQKNSGTDMEPRTVEINRELSDALGI 1689
Score = 49.6 bits (113), Expect = 3e-05
Identities = 26/96 (27%), Positives = 54/96 (56%), Gaps = 5/96 (5%)
Query: 186 TVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKIN 245
T+P + + V+L + GLG + G + SG+ V++I+ G A++ G+++
Sbjct: 236 TLPETVCWGHVEEVELINDGSGLGFGIVG-----GKTSGVVVRTIVPGGLADRDGRLQTG 290
Query: 246 DRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
D I+++ G ++ ++ Q ++LRN G SV +++ R
Sbjct: 291 DHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVAR 326
Score = 46.0 bits (104), Expect = 4e-04
Identities = 27/76 (35%), Positives = 41/76 (53%), Gaps = 2/76 (2%)
Query: 553 VMLVKAD-QGLGFSILDYQDPVDPN-GTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVS 610
V LV+ D Q LG I+ Y + I V+S++PG A NG I D++++V+GV+
Sbjct: 366 VELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVN 425
Query: 611 IQNATLDQAVQALKGA 626
IQ V+ L+ A
Sbjct: 426 IQGFANHDVVEVLRNA 441
Score = 45.6 bits (103), Expect = 6e-04
Identities = 35/111 (31%), Positives = 50/111 (45%), Gaps = 7/111 (6%)
Query: 352 QEELDQRFDEILAVDKEDIVKKWKEEIGSDKEILVAEIKKLEGLGISLEGTVDVEGGQEL 411
+ E+D D D + + W E+ +V +K +GLG S+ D
Sbjct: 658 ETEVDHNMDVNTEEDDDGELALWSPEVK-----IVELVKDCKGLGFSILDYQDPL--DPT 710
Query: 412 RPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP 462
R IRS++ DG G L GD L+ VNEY L + +E V ILK +P
Sbjct: 711 RSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAVP 761
Score = 44.4 bits (100), Expect = 0.001
Identities = 58/257 (22%), Positives = 99/257 (38%), Gaps = 24/257 (9%)
Query: 393 EGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHS 452
+ LGI + G V E Y++S++P G + D+++ V+ + G +
Sbjct: 374 QSLGIRIVGYVGTSHTGEASGI-YVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANH 432
Query: 453 EVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARK----IISGSLNNLTTL- 507
+VV +L+ V L R S P+ + E K ++G++ T +
Sbjct: 433 DVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLKPPALFLTGAVETETNVD 492
Query: 508 -----VKAQSDTSINTSSTA-----TLTNHSEQSKKSR-------SLECVSGLAMWQSKE 550
+K + DT N + A + + E KSR E + Q +
Sbjct: 493 GEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDYEVMVATLDTQIAD 552
Query: 551 DIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVS 610
D L K + L L VD + S+V GG + G + P D ++ VNG+
Sbjct: 553 D-AELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQ 611
Query: 611 IQNATLDQAVQALKGAP 627
+ + +AV LK P
Sbjct: 612 LYGKSRREAVSFLKEVP 628
Score = 43.6 bits (98), Expect = 0.002
Identities = 32/123 (26%), Positives = 59/123 (47%), Gaps = 6/123 (4%)
Query: 509 KAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILD 568
KA + T + +S AT T + ++ E + W + + + + LG SI+
Sbjct: 1027 KASAYTGMLSSRYATDTCELPEREEGEGEE-TPNFSHWGPPRIVEIFREPNVSLGISIVG 1085
Query: 569 YQDPVD--PNGTV---IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQAL 623
Q + NG I ++ ++ A K + GD+++ V+GV +QNA+ +AV+A+
Sbjct: 1086 GQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAI 1145
Query: 624 KGA 626
K A
Sbjct: 1146 KNA 1148
Score = 41.9 bits (94), Expect = 0.007
Identities = 25/89 (28%), Positives = 50/89 (56%), Gaps = 2/89 (2%)
Query: 195 EIIHVDLNK-NVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDG 253
+I ++D+ + + GLG +V + IFVK + GS A++ ++K ND+I+ ++
Sbjct: 131 QIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINH 190
Query: 254 ISLADK-SNPQSVEILRNTGISVHLVLER 281
L S+ Q++ +L+ T S+ L++ R
Sbjct: 191 TPLDQNISHQQAIALLQQTTGSLRLIVAR 219
Score = 41.5 bits (93), Expect = 0.009
Identities = 26/79 (32%), Positives = 46/79 (58%), Gaps = 3/79 (3%)
Query: 192 PEIEIIHVDLNKNVYGLGITVAGYVCEKEEL-SGIFVKSIIEGSSAEQSGKIKINDRIIE 250
PE++I V+L K+ GLG ++ Y + S I ++S++ AE+SG + DR++
Sbjct: 682 PEVKI--VELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVS 739
Query: 251 VDGISLADKSNPQSVEILR 269
V+ L + S ++VEIL+
Sbjct: 740 VNEYCLDNTSLAEAVEILK 758
Score = 40.3 bits (90), Expect = 0.021
Identities = 16/56 (28%), Positives = 32/56 (57%)
Query: 417 IRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARN 472
+R+++P G G L GD +L++ + G+T +V +L+ + VR++ AR+
Sbjct: 272 VRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARD 327
Score = 39.1 bits (87), Expect = 0.049
Identities = 32/111 (28%), Positives = 52/111 (46%), Gaps = 6/111 (5%)
Query: 379 GSDKEILVAEIKK--LEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGD 436
G+D E EI + + LGIS+ G G +I + G L GD
Sbjct: 1669 GTDMEPRTVEINRELSDALGISIAGG---RGSPLGDIPVFIAMIQASGVAARTQKLKVGD 1725
Query: 437 ELLEVNEYRLHGLTHSEVVNILKQLPDRVRL-VCARNSIDSGPRPVVNLAS 486
++ +N L GL+H++VVN+LK R+ L V A +I + + N+++
Sbjct: 1726 RIVSINGQPLDGLSHADVVNLLKNAYGRIILQVVADTNISAIAAQLENMST 1776
Score = 38.3 bits (85), Expect = 0.085
Identities = 25/93 (26%), Positives = 49/93 (52%), Gaps = 8/93 (8%)
Query: 7 WA-QVEVVELTNDGNGLGFNLVGGRS------TGVVIKYVLPGGVADKDRRLQSGDHVLQ 59
W+ +V++VEL D GLGF+++ + + +VI+ ++ GVA++ L GD ++
Sbjct: 680 WSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVS 739
Query: 60 VGSVNLRGFTSEQVAAVLRQAGP-VVRLLVARP 91
V L + + +L+ P +V L + +P
Sbjct: 740 VNEYCLDNTSLAEAVEILKAVPPGLVHLGICKP 772
Score = 37.1 bits (82), Expect = 0.20
Identities = 53/245 (21%), Positives = 94/245 (38%), Gaps = 25/245 (10%)
Query: 383 EILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVN 442
EI +++K G G+ L V G + +I ++ G L G L GD++L VN
Sbjct: 1530 EIFPVDLQKKAGRGLGLS-IVGKRNGSGV----FISDIVKGGAADLDGRLIQGDQILSVN 1584
Query: 443 EYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLN 502
+ + V ILK V+L R + +G S + S
Sbjct: 1585 GEDMRNASQETVATILKCAQGLVQLEIGR--LRAGSWTSARTTSQNSQGSQQSAHSSCHP 1642
Query: 503 NLTTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGL 562
+ ++ N T +++ S+++ SG M + + + L
Sbjct: 1643 SFAPVITGLQ----NLVGTKRVSDPSQKN---------SGTDM--EPRTVEINRELSDAL 1687
Query: 563 GFSILDYQDPVDPNGTV-IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQ 621
G SI + P G + + + + GVA + ++ GDR++S+NG + + V
Sbjct: 1688 GISIAGGRG--SPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVN 1745
Query: 622 ALKGA 626
LK A
Sbjct: 1746 LLKNA 1750
Score = 35.5 bits (78), Expect = 0.60
Identities = 21/73 (28%), Positives = 39/73 (53%), Gaps = 1/73 (1%)
Query: 199 VDLNKNVY-GLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLA 257
V++N+ + LGI++AG +F+ I A ++ K+K+ DRI+ ++G L
Sbjct: 1677 VEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLD 1736
Query: 258 DKSNPQSVEILRN 270
S+ V +L+N
Sbjct: 1737 GLSHADVVNLLKN 1749
Score = 34.7 bits (76), Expect = 1.0
Identities = 23/84 (27%), Positives = 43/84 (51%), Gaps = 7/84 (8%)
Query: 13 VELTND-GNGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLR 66
VE+ + + LG ++ GGR + V I + GVA + ++L+ GD ++ + L
Sbjct: 1677 VEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLD 1736
Query: 67 GFTSEQVAAVLRQA-GPVVRLLVA 89
G + V +L+ A G ++ +VA
Sbjct: 1737 GLSHADVVNLLKNAYGRIILQVVA 1760
>AL449143-1|CAI15923.1| 1582|Homo sapiens InaD-like (Drosophila)
protein.
Length = 1582
Score = 126 bits (303), Expect = 3e-28
Identities = 99/316 (31%), Positives = 152/316 (48%), Gaps = 25/316 (7%)
Query: 178 SVSPTITITVPVELPEI------------EIIHVDL-NKNVYGLGITVAGYVCEKE--EL 222
SV+P +PV LP + E +V+L K+ LGI + GYV E
Sbjct: 333 SVTPPAPAALPVALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEA 392
Query: 223 SGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLERY 282
SGI+VKSII GS+A +G I++ND+I+ VDG+++ +N VE+LRN G VHL L R
Sbjct: 393 SGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRR 452
Query: 283 LRGPKFEHLQLAIFNEERXXXXXXXXXXLSW-FPVPSQLENSITEIEPEPESNTTIDSSV 341
L+ L+ + ++ EI+ ++ +
Sbjct: 453 KTSSSTSPLEPPSDRGTVVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQA 512
Query: 342 LE-VGDLQEPTQEELDQRFDEILAVDKEDIVKKWKEEIGSDKEI-LVAEIKKLEGLGISL 399
LE + + + + EL R++ +L D E +V +I D E+ +++ + L + +
Sbjct: 513 LEKLEKVPDSPENELKSRWENLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGV 572
Query: 400 EGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILK 459
E VD G HHYI S++ GPV G+L DELLEVN +L+G + E V+ LK
Sbjct: 573 E--VDSFDG-----HHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLK 625
Query: 460 QLPDRVRLVCARNSID 475
++P LVC R D
Sbjct: 626 EVPPPFTLVCCRRLFD 641
Score = 125 bits (302), Expect = 4e-28
Identities = 57/106 (53%), Positives = 78/106 (73%), Gaps = 2/106 (1%)
Query: 7 WAQVEVVELTNDGNGLGFNLVGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLR 66
W VE VEL NDG+GLGF +VGG+++GVV++ ++PGG+AD+D RLQ+GDH+L++G N++
Sbjct: 243 WGHVEEVELINDGSGLGFGIVGGKTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQ 302
Query: 67 GFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVPTKI 112
G TSEQVA VLR G VR+LVAR DPA + P A +P +
Sbjct: 303 GMTSEQVAQVLRNCGNSVRMLVAR--DPAGDISVTPPAPAALPVAL 346
Score = 114 bits (274), Expect = 1e-24
Identities = 55/105 (52%), Positives = 74/105 (70%)
Query: 543 LAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDR 602
LA+W + IV LVK +GLGFSILDYQDP+DP +VIV+RSLV GVAE++G + PGDR
Sbjct: 677 LALWSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDR 736
Query: 603 VMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPLPPQDSSKS 647
++SVN + N +L +AV+ LK P G V +GI +PL + +S
Sbjct: 737 LVSVNEYCLDNTSLAEAVEILKAVPPGLVHLGICKPLVEDNEEES 781
Score = 89.4 bits (212), Expect = 3e-17
Identities = 72/275 (26%), Positives = 127/275 (46%), Gaps = 29/275 (10%)
Query: 198 HVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLA 257
+V L ++ G G TV + EEL GIF+K ++E S A ++ +K D+I+EV G+ L
Sbjct: 1076 NVSLGISIVG-GQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQ 1134
Query: 258 DKSNPQSVEILRNTGISVHLVLERYLRGPKFEHLQLAIFNEERXXXXXXXXXXLSWFPVP 317
+ S+ ++VE ++N G V +++ P+ I N
Sbjct: 1135 NASHSEAVEAIKNAGNPVVFIVQSLSSTPR------VIPNVHNKANKITGN--------- 1179
Query: 318 SQLENSITEIEPEPESNTTIDSSVLEVGDLQEPTQEELDQRFDEILAVDKEDIVKKWKEE 377
+N T+ + E T +++ + ++ D+ +E D++ +++ +
Sbjct: 1180 ---QNQDTQEKKEKRQGTA--PPPMKLPPPYKALTDDSDENEEEDAFTDQK--IRQRYAD 1232
Query: 378 IGSDKEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDE 437
+ + I+ E K GLG+SL G D R ++ + P+GP G + GDE
Sbjct: 1233 LPGELHIIELE-KDKNGLGLSLAGNKD-----RSRMSIFVVGINPEGPAAADGRMRIGDE 1286
Query: 438 LLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARN 472
LLE+N L+G +H I+K P +V+LV RN
Sbjct: 1287 LLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRN 1321
Score = 71.3 bits (167), Expect = 1e-11
Identities = 80/291 (27%), Positives = 126/291 (43%), Gaps = 37/291 (12%)
Query: 13 VELTN-DGNGLGFNLVG-------GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
VEL DG LG +VG G ++G+ +K ++PG A + +Q D ++ V VN
Sbjct: 366 VELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVN 425
Query: 65 LRGFTSEQVAAVLRQAGPVVRL-LVARPADPATA-LRAPQP-GTALVPTKILADPELLDR 121
++GF + V VLR AG VV L LV R +T+ L P GT + P K P L
Sbjct: 426 IQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLK---PPALFLT 482
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIG--DNPQKIPDHP------ 173
+ET + N++G++ E + I I + +K+PD P
Sbjct: 483 GAVET-------------ETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKS 529
Query: 174 IVCDSVSPTITITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSG-IFVKSIIE 232
+ + P + V +I +L K L I E + G ++ SI+
Sbjct: 530 RWENLLGPDYEVMVATLDTQI-ADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVS 588
Query: 233 GSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLERYL 283
G + G ++ D ++EV+G+ L KS ++V L+ LV R L
Sbjct: 589 GGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRL 639
Score = 59.3 bits (137), Expect = 4e-08
Identities = 65/245 (26%), Positives = 109/245 (44%), Gaps = 24/245 (9%)
Query: 395 LGISLEGTVDV----EGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLT 450
LGIS+ G V + G+EL+ +I+ VL D P G L GD++LEV+ L +
Sbjct: 1079 LGISIVGGQTVIKRLKNGEELKGI-FIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNAS 1137
Query: 451 HSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKA 510
HSE V +K + V + S+ S PR + N+ + +A K I+G+ N T K
Sbjct: 1138 HSEAVEAIKNAGNPVVFIV--QSLSSTPRVIPNVHN-----KANK-ITGNQNQDTQEKKE 1189
Query: 511 QSDTSINTSST-----ATLTNHSEQSKKSRSL---ECVSGLAMWQSKEDIVMLVKADQGL 562
+ + LT+ S+++++ + + A + I+ L K GL
Sbjct: 1190 KRQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGL 1249
Query: 563 GFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQA 622
G S+ + D + I V + P G A +G + GD ++ +N + + A
Sbjct: 1250 GLSLAGNK---DRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAI 1306
Query: 623 LKGAP 627
+K AP
Sbjct: 1307 IKTAP 1311
Score = 55.2 bits (127), Expect = 7e-07
Identities = 30/92 (32%), Positives = 52/92 (56%), Gaps = 8/92 (8%)
Query: 546 WQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMS 605
W E+ V L+ GLGF I V + +VVR++VPGG+A+++G + GD ++
Sbjct: 243 WGHVEE-VELINDGSGLGFGI------VGGKTSGVVVRTIVPGGLADRDGRLQTGDHILK 295
Query: 606 VNGVSIQNATLDQAVQALKGAPRGTVKVGIAR 637
+ G ++Q T +Q Q L+ +V++ +AR
Sbjct: 296 IGGTNVQGMTSEQVAQVLRNC-GNSVRMLVAR 326
Score = 52.4 bits (120), Expect = 5e-06
Identities = 31/89 (34%), Positives = 51/89 (57%), Gaps = 7/89 (7%)
Query: 9 QVEVVELTNDGNG-LGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDHVLQVGS 62
Q+E +++ G LGF++V RS + +K V PG VAD+D+RL+ D +L +
Sbjct: 131 QIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINH 190
Query: 63 VNL-RGFTSEQVAAVLRQAGPVVRLLVAR 90
L + + +Q A+L+Q +RL+VAR
Sbjct: 191 TPLDQNISHQQAIALLQQTTGSLRLIVAR 219
Score = 51.2 bits (117), Expect = 1e-05
Identities = 30/108 (27%), Positives = 56/108 (51%), Gaps = 4/108 (3%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTGVVIKYVL---PGGVADKDRRLQSGDHVLQVGSVNL 65
++ ++EL D NGLG +L G + + +V+ P G A D R++ GD +L++ + L
Sbjct: 1236 ELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQIL 1295
Query: 66 RGFTSEQVAAVLRQAGPVVRLLVARPADPATALR-APQPGTALVPTKI 112
G + + +A+++ A V+L+ R D + P P + P+ I
Sbjct: 1296 YGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSI 1343
Score = 49.6 bits (113), Expect = 3e-05
Identities = 26/96 (27%), Positives = 54/96 (56%), Gaps = 5/96 (5%)
Query: 186 TVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKIN 245
T+P + + V+L + GLG + G + SG+ V++I+ G A++ G+++
Sbjct: 236 TLPETVCWGHVEEVELINDGSGLGFGIVG-----GKTSGVVVRTIVPGGLADRDGRLQTG 290
Query: 246 DRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
D I+++ G ++ ++ Q ++LRN G SV +++ R
Sbjct: 291 DHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVAR 326
Score = 46.4 bits (105), Expect = 3e-04
Identities = 23/56 (41%), Positives = 31/56 (55%)
Query: 417 IRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARN 472
I V +G G L AGD++LEVN L +H E + L+Q P +VRLV R+
Sbjct: 1494 IHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRD 1549
Score = 46.0 bits (104), Expect = 4e-04
Identities = 27/76 (35%), Positives = 41/76 (53%), Gaps = 2/76 (2%)
Query: 553 VMLVKAD-QGLGFSILDYQDPVDPN-GTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVS 610
V LV+ D Q LG I+ Y + I V+S++PG A NG I D++++V+GV+
Sbjct: 366 VELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVN 425
Query: 611 IQNATLDQAVQALKGA 626
IQ V+ L+ A
Sbjct: 426 IQGFANHDVVEVLRNA 441
Score = 45.6 bits (103), Expect = 6e-04
Identities = 35/111 (31%), Positives = 50/111 (45%), Gaps = 7/111 (6%)
Query: 352 QEELDQRFDEILAVDKEDIVKKWKEEIGSDKEILVAEIKKLEGLGISLEGTVDVEGGQEL 411
+ E+D D D + + W E+ +V +K +GLG S+ D
Sbjct: 658 ETEVDHNMDVNTEEDDDGELALWSPEVK-----IVELVKDCKGLGFSILDYQDPL--DPT 710
Query: 412 RPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP 462
R IRS++ DG G L GD L+ VNEY L + +E V ILK +P
Sbjct: 711 RSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAVP 761
Score = 45.6 bits (103), Expect = 6e-04
Identities = 24/57 (42%), Positives = 33/57 (57%)
Query: 34 VVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVAR 90
+VI V G A +D RL +GD +L+V V+LR + E+ LRQ VRL+V R
Sbjct: 1492 IVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYR 1548
Score = 44.4 bits (100), Expect = 0.001
Identities = 58/257 (22%), Positives = 99/257 (38%), Gaps = 24/257 (9%)
Query: 393 EGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHS 452
+ LGI + G V E Y++S++P G + D+++ V+ + G +
Sbjct: 374 QSLGIRIVGYVGTSHTGEASGI-YVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANH 432
Query: 453 EVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARK----IISGSLNNLTTL- 507
+VV +L+ V L R S P+ + E K ++G++ T +
Sbjct: 433 DVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLKPPALFLTGAVETETNVD 492
Query: 508 -----VKAQSDTSINTSSTA-----TLTNHSEQSKKSR-------SLECVSGLAMWQSKE 550
+K + DT N + A + + E KSR E + Q +
Sbjct: 493 GEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDYEVMVATLDTQIAD 552
Query: 551 DIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVS 610
D L K + L L VD + S+V GG + G + P D ++ VNG+
Sbjct: 553 D-AELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQ 611
Query: 611 IQNATLDQAVQALKGAP 627
+ + +AV LK P
Sbjct: 612 LYGKSRREAVSFLKEVP 628
Score = 43.6 bits (98), Expect = 0.002
Identities = 32/123 (26%), Positives = 59/123 (47%), Gaps = 6/123 (4%)
Query: 509 KAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILD 568
KA + T + +S AT T + ++ E + W + + + + LG SI+
Sbjct: 1027 KASAYTGMLSSRYATDTCELPEREEGEGEE-TPNFSHWGPPRIVEIFREPNVSLGISIVG 1085
Query: 569 YQDPVD--PNGTV---IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQAL 623
Q + NG I ++ ++ A K + GD+++ V+GV +QNA+ +AV+A+
Sbjct: 1086 GQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAI 1145
Query: 624 KGA 626
K A
Sbjct: 1146 KNA 1148
Score = 43.6 bits (98), Expect = 0.002
Identities = 21/66 (31%), Positives = 38/66 (57%)
Query: 216 VCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISV 275
V E E + I + + E +A + G++ D+I+EV+G+ L + S+ +++ LR T V
Sbjct: 1483 VTEVEGQNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKV 1542
Query: 276 HLVLER 281
LV+ R
Sbjct: 1543 RLVVYR 1548
Score = 42.7 bits (96), Expect = 0.004
Identities = 16/49 (32%), Positives = 33/49 (67%)
Query: 580 IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPR 628
IV+ + G A ++G + GD+++ VNGV ++N++ ++A+ AL+ P+
Sbjct: 1492 IVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQ 1540
Score = 41.9 bits (94), Expect = 0.007
Identities = 25/89 (28%), Positives = 50/89 (56%), Gaps = 2/89 (2%)
Query: 195 EIIHVDLNK-NVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDG 253
+I ++D+ + + GLG +V + IFVK + GS A++ ++K ND+I+ ++
Sbjct: 131 QIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINH 190
Query: 254 ISLADK-SNPQSVEILRNTGISVHLVLER 281
L S+ Q++ +L+ T S+ L++ R
Sbjct: 191 TPLDQNISHQQAIALLQQTTGSLRLIVAR 219
Score = 41.5 bits (93), Expect = 0.009
Identities = 26/79 (32%), Positives = 46/79 (58%), Gaps = 3/79 (3%)
Query: 192 PEIEIIHVDLNKNVYGLGITVAGYVCEKEEL-SGIFVKSIIEGSSAEQSGKIKINDRIIE 250
PE++I V+L K+ GLG ++ Y + S I ++S++ AE+SG + DR++
Sbjct: 682 PEVKI--VELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVS 739
Query: 251 VDGISLADKSNPQSVEILR 269
V+ L + S ++VEIL+
Sbjct: 740 VNEYCLDNTSLAEAVEILK 758
Score = 40.3 bits (90), Expect = 0.021
Identities = 16/56 (28%), Positives = 32/56 (57%)
Query: 417 IRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARN 472
+R+++P G G L GD +L++ + G+T +V +L+ + VR++ AR+
Sbjct: 272 VRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARD 327
Score = 39.5 bits (88), Expect = 0.037
Identities = 25/87 (28%), Positives = 47/87 (54%), Gaps = 2/87 (2%)
Query: 195 EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGI 254
E+ ++L K+ GLG+++AG ++ +S IFV I A G+++I D ++E++
Sbjct: 1236 ELHIIELEKDKNGLGLSLAGNK-DRSRMS-IFVVGINPEGPAAADGRMRIGDELLEINNQ 1293
Query: 255 SLADKSNPQSVEILRNTGISVHLVLER 281
L +S+ + I++ V LV R
Sbjct: 1294 ILYGRSHQNASAIIKTAPSKVKLVFIR 1320
Score = 38.3 bits (85), Expect = 0.085
Identities = 25/93 (26%), Positives = 49/93 (52%), Gaps = 8/93 (8%)
Query: 7 WA-QVEVVELTNDGNGLGFNLVGGRS------TGVVIKYVLPGGVADKDRRLQSGDHVLQ 59
W+ +V++VEL D GLGF+++ + + +VI+ ++ GVA++ L GD ++
Sbjct: 680 WSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVS 739
Query: 60 VGSVNLRGFTSEQVAAVLRQAGP-VVRLLVARP 91
V L + + +L+ P +V L + +P
Sbjct: 740 VNEYCLDNTSLAEAVEILKAVPPGLVHLGICKP 772
>AL353802-3|CAI22262.1| 1801|Homo sapiens InaD-like (Drosophila)
protein.
Length = 1801
Score = 126 bits (303), Expect = 3e-28
Identities = 99/316 (31%), Positives = 152/316 (48%), Gaps = 25/316 (7%)
Query: 178 SVSPTITITVPVELPEI------------EIIHVDL-NKNVYGLGITVAGYVCEKE--EL 222
SV+P +PV LP + E +V+L K+ LGI + GYV E
Sbjct: 333 SVTPPAPAALPVALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEA 392
Query: 223 SGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLERY 282
SGI+VKSII GS+A +G I++ND+I+ VDG+++ +N VE+LRN G VHL L R
Sbjct: 393 SGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRR 452
Query: 283 LRGPKFEHLQLAIFNEERXXXXXXXXXXLSW-FPVPSQLENSITEIEPEPESNTTIDSSV 341
L+ L+ + ++ EI+ ++ +
Sbjct: 453 KTSSSTSPLEPPSDRGTVVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQA 512
Query: 342 LE-VGDLQEPTQEELDQRFDEILAVDKEDIVKKWKEEIGSDKEI-LVAEIKKLEGLGISL 399
LE + + + + EL R++ +L D E +V +I D E+ +++ + L + +
Sbjct: 513 LEKLEKVPDSPENELKSRWENLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGV 572
Query: 400 EGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILK 459
E VD G HHYI S++ GPV G+L DELLEVN +L+G + E V+ LK
Sbjct: 573 E--VDSFDG-----HHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLK 625
Query: 460 QLPDRVRLVCARNSID 475
++P LVC R D
Sbjct: 626 EVPPPFTLVCCRRLFD 641
Score = 125 bits (302), Expect = 4e-28
Identities = 57/106 (53%), Positives = 78/106 (73%), Gaps = 2/106 (1%)
Query: 7 WAQVEVVELTNDGNGLGFNLVGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLR 66
W VE VEL NDG+GLGF +VGG+++GVV++ ++PGG+AD+D RLQ+GDH+L++G N++
Sbjct: 243 WGHVEEVELINDGSGLGFGIVGGKTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQ 302
Query: 67 GFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVPTKI 112
G TSEQVA VLR G VR+LVAR DPA + P A +P +
Sbjct: 303 GMTSEQVAQVLRNCGNSVRMLVAR--DPAGDISVTPPAPAALPVAL 346
Score = 114 bits (274), Expect = 1e-24
Identities = 55/105 (52%), Positives = 74/105 (70%)
Query: 543 LAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDR 602
LA+W + IV LVK +GLGFSILDYQDP+DP +VIV+RSLV GVAE++G + PGDR
Sbjct: 677 LALWSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDR 736
Query: 603 VMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPLPPQDSSKS 647
++SVN + N +L +AV+ LK P G V +GI +PL + +S
Sbjct: 737 LVSVNEYCLDNTSLAEAVEILKAVPPGLVHLGICKPLVEDNEEES 781
Score = 89.4 bits (212), Expect = 3e-17
Identities = 72/275 (26%), Positives = 127/275 (46%), Gaps = 29/275 (10%)
Query: 198 HVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLA 257
+V L ++ G G TV + EEL GIF+K ++E S A ++ +K D+I+EV G+ L
Sbjct: 1076 NVSLGISIVG-GQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQ 1134
Query: 258 DKSNPQSVEILRNTGISVHLVLERYLRGPKFEHLQLAIFNEERXXXXXXXXXXLSWFPVP 317
+ S+ ++VE ++N G V +++ P+ I N
Sbjct: 1135 NASHSEAVEAIKNAGNPVVFIVQSLSSTPR------VIPNVHNKANKITGN--------- 1179
Query: 318 SQLENSITEIEPEPESNTTIDSSVLEVGDLQEPTQEELDQRFDEILAVDKEDIVKKWKEE 377
+N T+ + E T +++ + ++ D+ +E D++ +++ +
Sbjct: 1180 ---QNQDTQEKKEKRQGTA--PPPMKLPPPYKALTDDSDENEEEDAFTDQK--IRQRYAD 1232
Query: 378 IGSDKEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDE 437
+ + I+ E K GLG+SL G D R ++ + P+GP G + GDE
Sbjct: 1233 LPGELHIIELE-KDKNGLGLSLAGNKD-----RSRMSIFVVGINPEGPAAADGRMRIGDE 1286
Query: 438 LLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARN 472
LLE+N L+G +H I+K P +V+LV RN
Sbjct: 1287 LLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRN 1321
Score = 72.5 bits (170), Expect = 4e-12
Identities = 64/287 (22%), Positives = 134/287 (46%), Gaps = 18/287 (6%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTGVVIKYVL---PGGVADKDRRLQSGDHVLQVGSVNL 65
++ ++EL D NGLG +L G + + +V+ P G A D R++ GD +L++ + L
Sbjct: 1236 ELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQIL 1295
Query: 66 RGFTSEQVAAVLRQAGPVVRLLVARPADPATALRA---PQPGTALVPTKILADPELLDRH 122
G + + +A+++ A V+L+ R D + P P ++ + + E +
Sbjct: 1296 YGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSE 1355
Query: 123 ---LIETGYGAVYDLSQC-YSDYNINGQNGETETSIVAAAVSVIGDNPQKIPDHPIV-CD 177
+E G + + + + Q T+ S + + + + D
Sbjct: 1356 EDGSVEVGIKQLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYG 1415
Query: 178 SVSPTITI---TVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGS 234
+++ T P+ +P E+I ++++K GLG+++ G + L+ I + + E
Sbjct: 1416 GFQAPLSVDPATCPI-VPGQEMI-IEISKGRSGLGLSIVGG--KDTPLNAIVIHEVYEEG 1471
Query: 235 SAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
+A + G++ D+I+EV+G+ L + S+ +++ LR T V LV+ R
Sbjct: 1472 AAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYR 1518
Score = 71.3 bits (167), Expect = 1e-11
Identities = 80/291 (27%), Positives = 126/291 (43%), Gaps = 37/291 (12%)
Query: 13 VELTN-DGNGLGFNLVG-------GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
VEL DG LG +VG G ++G+ +K ++PG A + +Q D ++ V VN
Sbjct: 366 VELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVN 425
Query: 65 LRGFTSEQVAAVLRQAGPVVRL-LVARPADPATA-LRAPQP-GTALVPTKILADPELLDR 121
++GF + V VLR AG VV L LV R +T+ L P GT + P K P L
Sbjct: 426 IQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLK---PPALFLT 482
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIG--DNPQKIPDHP------ 173
+ET + N++G++ E + I I + +K+PD P
Sbjct: 483 GAVET-------------ETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKS 529
Query: 174 IVCDSVSPTITITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSG-IFVKSIIE 232
+ + P + V +I +L K L I E + G ++ SI+
Sbjct: 530 RWENLLGPDYEVMVATLDTQI-ADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVS 588
Query: 233 GSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLERYL 283
G + G ++ D ++EV+G+ L KS ++V L+ LV R L
Sbjct: 589 GGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRL 639
Score = 59.3 bits (137), Expect = 4e-08
Identities = 65/245 (26%), Positives = 109/245 (44%), Gaps = 24/245 (9%)
Query: 395 LGISLEGTVDV----EGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLT 450
LGIS+ G V + G+EL+ +I+ VL D P G L GD++LEV+ L +
Sbjct: 1079 LGISIVGGQTVIKRLKNGEELKGI-FIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNAS 1137
Query: 451 HSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKA 510
HSE V +K + V + S+ S PR + N+ + +A K I+G+ N T K
Sbjct: 1138 HSEAVEAIKNAGNPVVFIV--QSLSSTPRVIPNVHN-----KANK-ITGNQNQDTQEKKE 1189
Query: 511 QSDTSINTSST-----ATLTNHSEQSKKSRSL---ECVSGLAMWQSKEDIVMLVKADQGL 562
+ + LT+ S+++++ + + A + I+ L K GL
Sbjct: 1190 KRQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGL 1249
Query: 563 GFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQA 622
G S+ + D + I V + P G A +G + GD ++ +N + + A
Sbjct: 1250 GLSLAGNK---DRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAI 1306
Query: 623 LKGAP 627
+K AP
Sbjct: 1307 IKTAP 1311
Score = 57.6 bits (133), Expect = 1e-07
Identities = 30/73 (41%), Positives = 45/73 (61%), Gaps = 1/73 (1%)
Query: 19 GNGLGFNLVGGRS-TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAVL 77
G GLG ++VG R+ +GV I ++ GG AD D RL GD +L V ++R + E VA +L
Sbjct: 1541 GRGLGLSIVGKRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATIL 1600
Query: 78 RQAGPVVRLLVAR 90
+ A +V+L + R
Sbjct: 1601 KCAQGLVQLEIGR 1613
Score = 55.2 bits (127), Expect = 7e-07
Identities = 30/92 (32%), Positives = 52/92 (56%), Gaps = 8/92 (8%)
Query: 546 WQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMS 605
W E+ V L+ GLGF I V + +VVR++VPGG+A+++G + GD ++
Sbjct: 243 WGHVEE-VELINDGSGLGFGI------VGGKTSGVVVRTIVPGGLADRDGRLQTGDHILK 295
Query: 606 VNGVSIQNATLDQAVQALKGAPRGTVKVGIAR 637
+ G ++Q T +Q Q L+ +V++ +AR
Sbjct: 296 IGGTNVQGMTSEQVAQVLRNC-GNSVRMLVAR 326
Score = 52.4 bits (120), Expect = 5e-06
Identities = 31/89 (34%), Positives = 51/89 (57%), Gaps = 7/89 (7%)
Query: 9 QVEVVELTNDGNG-LGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDHVLQVGS 62
Q+E +++ G LGF++V RS + +K V PG VAD+D+RL+ D +L +
Sbjct: 131 QIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINH 190
Query: 63 VNL-RGFTSEQVAAVLRQAGPVVRLLVAR 90
L + + +Q A+L+Q +RL+VAR
Sbjct: 191 TPLDQNISHQQAIALLQQTTGSLRLIVAR 219
Score = 51.6 bits (118), Expect = 9e-06
Identities = 29/81 (35%), Positives = 49/81 (60%), Gaps = 6/81 (7%)
Query: 557 KADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATL 616
KA +GLG SI+ + NG+ + + +V GG A+ +G + GD+++SVNG ++NA+
Sbjct: 1539 KAGRGLGLSIVGKR-----NGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQ 1593
Query: 617 DQAVQALKGAPRGTVKVGIAR 637
+ LK A +G V++ I R
Sbjct: 1594 ETVATILKCA-QGLVQLEIGR 1613
Score = 50.8 bits (116), Expect = 1e-05
Identities = 26/81 (32%), Positives = 50/81 (61%), Gaps = 5/81 (6%)
Query: 549 KEDIVMLVKADQGLGFSILDYQD-PVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVN 607
+E I+ + K GLG SI+ +D P++ IV+ + G A ++G + GD+++ VN
Sbjct: 1434 QEMIIEISKGRSGLGLSIVGGKDTPLN----AIVIHEVYEEGAAARDGRLWAGDQILEVN 1489
Query: 608 GVSIQNATLDQAVQALKGAPR 628
GV ++N++ ++A+ AL+ P+
Sbjct: 1490 GVDLRNSSHEEAITALRQTPQ 1510
Score = 50.4 bits (115), Expect = 2e-05
Identities = 31/91 (34%), Positives = 46/91 (50%), Gaps = 5/91 (5%)
Query: 382 KEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEV 441
+E+++ K GLG+S+ G D + I V +G G L AGD++LEV
Sbjct: 1434 QEMIIEISKGRSGLGLSIVGGKDTPLNAIV-----IHEVYEEGAAARDGRLWAGDQILEV 1488
Query: 442 NEYRLHGLTHSEVVNILKQLPDRVRLVCARN 472
N L +H E + L+Q P +VRLV R+
Sbjct: 1489 NGVDLRNSSHEEAITALRQTPQKVRLVVYRD 1519
Score = 50.0 bits (114), Expect = 3e-05
Identities = 43/173 (24%), Positives = 75/173 (43%), Gaps = 13/173 (7%)
Query: 194 IEIIHVDLNKNV-YGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVD 252
+EI VDL K GLG+++ G K SG+F+ I++G +A+ G++ D+I+ V+
Sbjct: 1529 LEIFPVDLQKKAGRGLGLSIVG----KRNGSGVFISDIVKGGAADLDGRLIQGDQILSVN 1584
Query: 253 GISLADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHLQLAIFNEERXXXXXXXXXXLS 312
G + + S IL+ V L + R LR + + N + S
Sbjct: 1585 GEDMRNASQETVATILKCAQGLVQLEIGR-LRAGSWTSARTTSQNSQGSQQSAHSSCHPS 1643
Query: 313 WFPVPSQLENSITEIEPEPESNTTIDSSVLEVGDLQEPTQEELDQRFDEILAV 365
+ PV + L+N + + D S G EP E+++ + L +
Sbjct: 1644 FAPVITGLQNLV-------GTKRVSDPSQKNSGTDMEPRTVEINRELSDALGI 1689
Score = 49.6 bits (113), Expect = 3e-05
Identities = 26/96 (27%), Positives = 54/96 (56%), Gaps = 5/96 (5%)
Query: 186 TVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKIN 245
T+P + + V+L + GLG + G + SG+ V++I+ G A++ G+++
Sbjct: 236 TLPETVCWGHVEEVELINDGSGLGFGIVG-----GKTSGVVVRTIVPGGLADRDGRLQTG 290
Query: 246 DRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
D I+++ G ++ ++ Q ++LRN G SV +++ R
Sbjct: 291 DHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVAR 326
Score = 46.0 bits (104), Expect = 4e-04
Identities = 27/76 (35%), Positives = 41/76 (53%), Gaps = 2/76 (2%)
Query: 553 VMLVKAD-QGLGFSILDYQDPVDPN-GTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVS 610
V LV+ D Q LG I+ Y + I V+S++PG A NG I D++++V+GV+
Sbjct: 366 VELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVN 425
Query: 611 IQNATLDQAVQALKGA 626
IQ V+ L+ A
Sbjct: 426 IQGFANHDVVEVLRNA 441
Score = 45.6 bits (103), Expect = 6e-04
Identities = 35/111 (31%), Positives = 50/111 (45%), Gaps = 7/111 (6%)
Query: 352 QEELDQRFDEILAVDKEDIVKKWKEEIGSDKEILVAEIKKLEGLGISLEGTVDVEGGQEL 411
+ E+D D D + + W E+ +V +K +GLG S+ D
Sbjct: 658 ETEVDHNMDVNTEEDDDGELALWSPEVK-----IVELVKDCKGLGFSILDYQDPL--DPT 710
Query: 412 RPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP 462
R IRS++ DG G L GD L+ VNEY L + +E V ILK +P
Sbjct: 711 RSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAVP 761
Score = 44.4 bits (100), Expect = 0.001
Identities = 58/257 (22%), Positives = 99/257 (38%), Gaps = 24/257 (9%)
Query: 393 EGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHS 452
+ LGI + G V E Y++S++P G + D+++ V+ + G +
Sbjct: 374 QSLGIRIVGYVGTSHTGEASGI-YVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANH 432
Query: 453 EVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARK----IISGSLNNLTTL- 507
+VV +L+ V L R S P+ + E K ++G++ T +
Sbjct: 433 DVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLKPPALFLTGAVETETNVD 492
Query: 508 -----VKAQSDTSINTSSTA-----TLTNHSEQSKKSR-------SLECVSGLAMWQSKE 550
+K + DT N + A + + E KSR E + Q +
Sbjct: 493 GEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDYEVMVATLDTQIAD 552
Query: 551 DIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVS 610
D L K + L L VD + S+V GG + G + P D ++ VNG+
Sbjct: 553 D-AELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQ 611
Query: 611 IQNATLDQAVQALKGAP 627
+ + +AV LK P
Sbjct: 612 LYGKSRREAVSFLKEVP 628
Score = 43.6 bits (98), Expect = 0.002
Identities = 32/123 (26%), Positives = 59/123 (47%), Gaps = 6/123 (4%)
Query: 509 KAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILD 568
KA + T + +S AT T + ++ E + W + + + + LG SI+
Sbjct: 1027 KASAYTGMLSSRYATDTCELPEREEGEGEE-TPNFSHWGPPRIVEIFREPNVSLGISIVG 1085
Query: 569 YQDPVD--PNGTV---IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQAL 623
Q + NG I ++ ++ A K + GD+++ V+GV +QNA+ +AV+A+
Sbjct: 1086 GQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAI 1145
Query: 624 KGA 626
K A
Sbjct: 1146 KNA 1148
Score = 41.9 bits (94), Expect = 0.007
Identities = 25/89 (28%), Positives = 50/89 (56%), Gaps = 2/89 (2%)
Query: 195 EIIHVDLNK-NVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDG 253
+I ++D+ + + GLG +V + IFVK + GS A++ ++K ND+I+ ++
Sbjct: 131 QIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINH 190
Query: 254 ISLADK-SNPQSVEILRNTGISVHLVLER 281
L S+ Q++ +L+ T S+ L++ R
Sbjct: 191 TPLDQNISHQQAIALLQQTTGSLRLIVAR 219
Score = 41.5 bits (93), Expect = 0.009
Identities = 26/79 (32%), Positives = 46/79 (58%), Gaps = 3/79 (3%)
Query: 192 PEIEIIHVDLNKNVYGLGITVAGYVCEKEEL-SGIFVKSIIEGSSAEQSGKIKINDRIIE 250
PE++I V+L K+ GLG ++ Y + S I ++S++ AE+SG + DR++
Sbjct: 682 PEVKI--VELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVS 739
Query: 251 VDGISLADKSNPQSVEILR 269
V+ L + S ++VEIL+
Sbjct: 740 VNEYCLDNTSLAEAVEILK 758
Score = 40.3 bits (90), Expect = 0.021
Identities = 16/56 (28%), Positives = 32/56 (57%)
Query: 417 IRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARN 472
+R+++P G G L GD +L++ + G+T +V +L+ + VR++ AR+
Sbjct: 272 VRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARD 327
Score = 39.1 bits (87), Expect = 0.049
Identities = 32/111 (28%), Positives = 52/111 (46%), Gaps = 6/111 (5%)
Query: 379 GSDKEILVAEIKK--LEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGD 436
G+D E EI + + LGIS+ G G +I + G L GD
Sbjct: 1669 GTDMEPRTVEINRELSDALGISIAGG---RGSPLGDIPVFIAMIQASGVAARTQKLKVGD 1725
Query: 437 ELLEVNEYRLHGLTHSEVVNILKQLPDRVRL-VCARNSIDSGPRPVVNLAS 486
++ +N L GL+H++VVN+LK R+ L V A +I + + N+++
Sbjct: 1726 RIVSINGQPLDGLSHADVVNLLKNAYGRIILQVVADTNISAIAAQLENMST 1776
Score = 38.3 bits (85), Expect = 0.085
Identities = 25/93 (26%), Positives = 49/93 (52%), Gaps = 8/93 (8%)
Query: 7 WA-QVEVVELTNDGNGLGFNLVGGRS------TGVVIKYVLPGGVADKDRRLQSGDHVLQ 59
W+ +V++VEL D GLGF+++ + + +VI+ ++ GVA++ L GD ++
Sbjct: 680 WSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVS 739
Query: 60 VGSVNLRGFTSEQVAAVLRQAGP-VVRLLVARP 91
V L + + +L+ P +V L + +P
Sbjct: 740 VNEYCLDNTSLAEAVEILKAVPPGLVHLGICKP 772
Score = 37.1 bits (82), Expect = 0.20
Identities = 53/245 (21%), Positives = 94/245 (38%), Gaps = 25/245 (10%)
Query: 383 EILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVN 442
EI +++K G G+ L V G + +I ++ G L G L GD++L VN
Sbjct: 1530 EIFPVDLQKKAGRGLGLS-IVGKRNGSGV----FISDIVKGGAADLDGRLIQGDQILSVN 1584
Query: 443 EYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLN 502
+ + V ILK V+L R + +G S + S
Sbjct: 1585 GEDMRNASQETVATILKCAQGLVQLEIGR--LRAGSWTSARTTSQNSQGSQQSAHSSCHP 1642
Query: 503 NLTTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGL 562
+ ++ N T +++ S+++ SG M + + + L
Sbjct: 1643 SFAPVITGLQ----NLVGTKRVSDPSQKN---------SGTDM--EPRTVEINRELSDAL 1687
Query: 563 GFSILDYQDPVDPNGTV-IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQ 621
G SI + P G + + + + GVA + ++ GDR++S+NG + + V
Sbjct: 1688 GISIAGGRG--SPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVN 1745
Query: 622 ALKGA 626
LK A
Sbjct: 1746 LLKNA 1750
Score = 35.5 bits (78), Expect = 0.60
Identities = 21/73 (28%), Positives = 39/73 (53%), Gaps = 1/73 (1%)
Query: 199 VDLNKNVY-GLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLA 257
V++N+ + LGI++AG +F+ I A ++ K+K+ DRI+ ++G L
Sbjct: 1677 VEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLD 1736
Query: 258 DKSNPQSVEILRN 270
S+ V +L+N
Sbjct: 1737 GLSHADVVNLLKN 1749
Score = 34.7 bits (76), Expect = 1.0
Identities = 23/84 (27%), Positives = 43/84 (51%), Gaps = 7/84 (8%)
Query: 13 VELTND-GNGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLR 66
VE+ + + LG ++ GGR + V I + GVA + ++L+ GD ++ + L
Sbjct: 1677 VEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLD 1736
Query: 67 GFTSEQVAAVLRQA-GPVVRLLVA 89
G + V +L+ A G ++ +VA
Sbjct: 1737 GLSHADVVNLLKNAYGRIILQVVA 1760
>AL353802-2|CAI22260.1| 1582|Homo sapiens InaD-like (Drosophila)
protein.
Length = 1582
Score = 126 bits (303), Expect = 3e-28
Identities = 99/316 (31%), Positives = 152/316 (48%), Gaps = 25/316 (7%)
Query: 178 SVSPTITITVPVELPEI------------EIIHVDL-NKNVYGLGITVAGYVCEKE--EL 222
SV+P +PV LP + E +V+L K+ LGI + GYV E
Sbjct: 333 SVTPPAPAALPVALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEA 392
Query: 223 SGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLERY 282
SGI+VKSII GS+A +G I++ND+I+ VDG+++ +N VE+LRN G VHL L R
Sbjct: 393 SGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRR 452
Query: 283 LRGPKFEHLQLAIFNEERXXXXXXXXXXLSW-FPVPSQLENSITEIEPEPESNTTIDSSV 341
L+ L+ + ++ EI+ ++ +
Sbjct: 453 KTSSSTSPLEPPSDRGTVVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQA 512
Query: 342 LE-VGDLQEPTQEELDQRFDEILAVDKEDIVKKWKEEIGSDKEI-LVAEIKKLEGLGISL 399
LE + + + + EL R++ +L D E +V +I D E+ +++ + L + +
Sbjct: 513 LEKLEKVPDSPENELKSRWENLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGV 572
Query: 400 EGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILK 459
E VD G HHYI S++ GPV G+L DELLEVN +L+G + E V+ LK
Sbjct: 573 E--VDSFDG-----HHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLK 625
Query: 460 QLPDRVRLVCARNSID 475
++P LVC R D
Sbjct: 626 EVPPPFTLVCCRRLFD 641
Score = 125 bits (302), Expect = 4e-28
Identities = 57/106 (53%), Positives = 78/106 (73%), Gaps = 2/106 (1%)
Query: 7 WAQVEVVELTNDGNGLGFNLVGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLR 66
W VE VEL NDG+GLGF +VGG+++GVV++ ++PGG+AD+D RLQ+GDH+L++G N++
Sbjct: 243 WGHVEEVELINDGSGLGFGIVGGKTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQ 302
Query: 67 GFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVPTKI 112
G TSEQVA VLR G VR+LVAR DPA + P A +P +
Sbjct: 303 GMTSEQVAQVLRNCGNSVRMLVAR--DPAGDISVTPPAPAALPVAL 346
Score = 114 bits (274), Expect = 1e-24
Identities = 55/105 (52%), Positives = 74/105 (70%)
Query: 543 LAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDR 602
LA+W + IV LVK +GLGFSILDYQDP+DP +VIV+RSLV GVAE++G + PGDR
Sbjct: 677 LALWSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDR 736
Query: 603 VMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPLPPQDSSKS 647
++SVN + N +L +AV+ LK P G V +GI +PL + +S
Sbjct: 737 LVSVNEYCLDNTSLAEAVEILKAVPPGLVHLGICKPLVEDNEEES 781
Score = 89.4 bits (212), Expect = 3e-17
Identities = 72/275 (26%), Positives = 127/275 (46%), Gaps = 29/275 (10%)
Query: 198 HVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLA 257
+V L ++ G G TV + EEL GIF+K ++E S A ++ +K D+I+EV G+ L
Sbjct: 1076 NVSLGISIVG-GQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQ 1134
Query: 258 DKSNPQSVEILRNTGISVHLVLERYLRGPKFEHLQLAIFNEERXXXXXXXXXXLSWFPVP 317
+ S+ ++VE ++N G V +++ P+ I N
Sbjct: 1135 NASHSEAVEAIKNAGNPVVFIVQSLSSTPR------VIPNVHNKANKITGN--------- 1179
Query: 318 SQLENSITEIEPEPESNTTIDSSVLEVGDLQEPTQEELDQRFDEILAVDKEDIVKKWKEE 377
+N T+ + E T +++ + ++ D+ +E D++ +++ +
Sbjct: 1180 ---QNQDTQEKKEKRQGTA--PPPMKLPPPYKALTDDSDENEEEDAFTDQK--IRQRYAD 1232
Query: 378 IGSDKEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDE 437
+ + I+ E K GLG+SL G D R ++ + P+GP G + GDE
Sbjct: 1233 LPGELHIIELE-KDKNGLGLSLAGNKD-----RSRMSIFVVGINPEGPAAADGRMRIGDE 1286
Query: 438 LLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARN 472
LLE+N L+G +H I+K P +V+LV RN
Sbjct: 1287 LLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRN 1321
Score = 71.3 bits (167), Expect = 1e-11
Identities = 80/291 (27%), Positives = 126/291 (43%), Gaps = 37/291 (12%)
Query: 13 VELTN-DGNGLGFNLVG-------GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
VEL DG LG +VG G ++G+ +K ++PG A + +Q D ++ V VN
Sbjct: 366 VELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVN 425
Query: 65 LRGFTSEQVAAVLRQAGPVVRL-LVARPADPATA-LRAPQP-GTALVPTKILADPELLDR 121
++GF + V VLR AG VV L LV R +T+ L P GT + P K P L
Sbjct: 426 IQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLK---PPALFLT 482
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIG--DNPQKIPDHP------ 173
+ET + N++G++ E + I I + +K+PD P
Sbjct: 483 GAVET-------------ETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKS 529
Query: 174 IVCDSVSPTITITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSG-IFVKSIIE 232
+ + P + V +I +L K L I E + G ++ SI+
Sbjct: 530 RWENLLGPDYEVMVATLDTQI-ADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVS 588
Query: 233 GSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLERYL 283
G + G ++ D ++EV+G+ L KS ++V L+ LV R L
Sbjct: 589 GGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRL 639
Score = 59.3 bits (137), Expect = 4e-08
Identities = 65/245 (26%), Positives = 109/245 (44%), Gaps = 24/245 (9%)
Query: 395 LGISLEGTVDV----EGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLT 450
LGIS+ G V + G+EL+ +I+ VL D P G L GD++LEV+ L +
Sbjct: 1079 LGISIVGGQTVIKRLKNGEELKGI-FIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNAS 1137
Query: 451 HSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKA 510
HSE V +K + V + S+ S PR + N+ + +A K I+G+ N T K
Sbjct: 1138 HSEAVEAIKNAGNPVVFIV--QSLSSTPRVIPNVHN-----KANK-ITGNQNQDTQEKKE 1189
Query: 511 QSDTSINTSST-----ATLTNHSEQSKKSRSL---ECVSGLAMWQSKEDIVMLVKADQGL 562
+ + LT+ S+++++ + + A + I+ L K GL
Sbjct: 1190 KRQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGL 1249
Query: 563 GFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQA 622
G S+ + D + I V + P G A +G + GD ++ +N + + A
Sbjct: 1250 GLSLAGNK---DRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAI 1306
Query: 623 LKGAP 627
+K AP
Sbjct: 1307 IKTAP 1311
Score = 55.2 bits (127), Expect = 7e-07
Identities = 30/92 (32%), Positives = 52/92 (56%), Gaps = 8/92 (8%)
Query: 546 WQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMS 605
W E+ V L+ GLGF I V + +VVR++VPGG+A+++G + GD ++
Sbjct: 243 WGHVEE-VELINDGSGLGFGI------VGGKTSGVVVRTIVPGGLADRDGRLQTGDHILK 295
Query: 606 VNGVSIQNATLDQAVQALKGAPRGTVKVGIAR 637
+ G ++Q T +Q Q L+ +V++ +AR
Sbjct: 296 IGGTNVQGMTSEQVAQVLRNC-GNSVRMLVAR 326
Score = 52.4 bits (120), Expect = 5e-06
Identities = 31/89 (34%), Positives = 51/89 (57%), Gaps = 7/89 (7%)
Query: 9 QVEVVELTNDGNG-LGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDHVLQVGS 62
Q+E +++ G LGF++V RS + +K V PG VAD+D+RL+ D +L +
Sbjct: 131 QIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINH 190
Query: 63 VNL-RGFTSEQVAAVLRQAGPVVRLLVAR 90
L + + +Q A+L+Q +RL+VAR
Sbjct: 191 TPLDQNISHQQAIALLQQTTGSLRLIVAR 219
Score = 51.2 bits (117), Expect = 1e-05
Identities = 30/108 (27%), Positives = 56/108 (51%), Gaps = 4/108 (3%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTGVVIKYVL---PGGVADKDRRLQSGDHVLQVGSVNL 65
++ ++EL D NGLG +L G + + +V+ P G A D R++ GD +L++ + L
Sbjct: 1236 ELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQIL 1295
Query: 66 RGFTSEQVAAVLRQAGPVVRLLVARPADPATALR-APQPGTALVPTKI 112
G + + +A+++ A V+L+ R D + P P + P+ I
Sbjct: 1296 YGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSI 1343
Score = 49.6 bits (113), Expect = 3e-05
Identities = 26/96 (27%), Positives = 54/96 (56%), Gaps = 5/96 (5%)
Query: 186 TVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKIN 245
T+P + + V+L + GLG + G + SG+ V++I+ G A++ G+++
Sbjct: 236 TLPETVCWGHVEEVELINDGSGLGFGIVG-----GKTSGVVVRTIVPGGLADRDGRLQTG 290
Query: 246 DRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
D I+++ G ++ ++ Q ++LRN G SV +++ R
Sbjct: 291 DHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVAR 326
Score = 46.4 bits (105), Expect = 3e-04
Identities = 23/56 (41%), Positives = 31/56 (55%)
Query: 417 IRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARN 472
I V +G G L AGD++LEVN L +H E + L+Q P +VRLV R+
Sbjct: 1494 IHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRD 1549
Score = 46.0 bits (104), Expect = 4e-04
Identities = 27/76 (35%), Positives = 41/76 (53%), Gaps = 2/76 (2%)
Query: 553 VMLVKAD-QGLGFSILDYQDPVDPN-GTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVS 610
V LV+ D Q LG I+ Y + I V+S++PG A NG I D++++V+GV+
Sbjct: 366 VELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVN 425
Query: 611 IQNATLDQAVQALKGA 626
IQ V+ L+ A
Sbjct: 426 IQGFANHDVVEVLRNA 441
Score = 45.6 bits (103), Expect = 6e-04
Identities = 35/111 (31%), Positives = 50/111 (45%), Gaps = 7/111 (6%)
Query: 352 QEELDQRFDEILAVDKEDIVKKWKEEIGSDKEILVAEIKKLEGLGISLEGTVDVEGGQEL 411
+ E+D D D + + W E+ +V +K +GLG S+ D
Sbjct: 658 ETEVDHNMDVNTEEDDDGELALWSPEVK-----IVELVKDCKGLGFSILDYQDPL--DPT 710
Query: 412 RPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP 462
R IRS++ DG G L GD L+ VNEY L + +E V ILK +P
Sbjct: 711 RSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAVP 761
Score = 45.6 bits (103), Expect = 6e-04
Identities = 24/57 (42%), Positives = 33/57 (57%)
Query: 34 VVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVAR 90
+VI V G A +D RL +GD +L+V V+LR + E+ LRQ VRL+V R
Sbjct: 1492 IVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYR 1548
Score = 44.4 bits (100), Expect = 0.001
Identities = 58/257 (22%), Positives = 99/257 (38%), Gaps = 24/257 (9%)
Query: 393 EGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHS 452
+ LGI + G V E Y++S++P G + D+++ V+ + G +
Sbjct: 374 QSLGIRIVGYVGTSHTGEASGI-YVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANH 432
Query: 453 EVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARK----IISGSLNNLTTL- 507
+VV +L+ V L R S P+ + E K ++G++ T +
Sbjct: 433 DVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLKPPALFLTGAVETETNVD 492
Query: 508 -----VKAQSDTSINTSSTA-----TLTNHSEQSKKSR-------SLECVSGLAMWQSKE 550
+K + DT N + A + + E KSR E + Q +
Sbjct: 493 GEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDYEVMVATLDTQIAD 552
Query: 551 DIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVS 610
D L K + L L VD + S+V GG + G + P D ++ VNG+
Sbjct: 553 D-AELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQ 611
Query: 611 IQNATLDQAVQALKGAP 627
+ + +AV LK P
Sbjct: 612 LYGKSRREAVSFLKEVP 628
Score = 43.6 bits (98), Expect = 0.002
Identities = 32/123 (26%), Positives = 59/123 (47%), Gaps = 6/123 (4%)
Query: 509 KAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILD 568
KA + T + +S AT T + ++ E + W + + + + LG SI+
Sbjct: 1027 KASAYTGMLSSRYATDTCELPEREEGEGEE-TPNFSHWGPPRIVEIFREPNVSLGISIVG 1085
Query: 569 YQDPVD--PNGTV---IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQAL 623
Q + NG I ++ ++ A K + GD+++ V+GV +QNA+ +AV+A+
Sbjct: 1086 GQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAI 1145
Query: 624 KGA 626
K A
Sbjct: 1146 KNA 1148
Score = 43.6 bits (98), Expect = 0.002
Identities = 21/66 (31%), Positives = 38/66 (57%)
Query: 216 VCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISV 275
V E E + I + + E +A + G++ D+I+EV+G+ L + S+ +++ LR T V
Sbjct: 1483 VTEVEGQNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKV 1542
Query: 276 HLVLER 281
LV+ R
Sbjct: 1543 RLVVYR 1548
Score = 42.7 bits (96), Expect = 0.004
Identities = 16/49 (32%), Positives = 33/49 (67%)
Query: 580 IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPR 628
IV+ + G A ++G + GD+++ VNGV ++N++ ++A+ AL+ P+
Sbjct: 1492 IVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQ 1540
Score = 41.9 bits (94), Expect = 0.007
Identities = 25/89 (28%), Positives = 50/89 (56%), Gaps = 2/89 (2%)
Query: 195 EIIHVDLNK-NVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDG 253
+I ++D+ + + GLG +V + IFVK + GS A++ ++K ND+I+ ++
Sbjct: 131 QIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINH 190
Query: 254 ISLADK-SNPQSVEILRNTGISVHLVLER 281
L S+ Q++ +L+ T S+ L++ R
Sbjct: 191 TPLDQNISHQQAIALLQQTTGSLRLIVAR 219
Score = 41.5 bits (93), Expect = 0.009
Identities = 26/79 (32%), Positives = 46/79 (58%), Gaps = 3/79 (3%)
Query: 192 PEIEIIHVDLNKNVYGLGITVAGYVCEKEEL-SGIFVKSIIEGSSAEQSGKIKINDRIIE 250
PE++I V+L K+ GLG ++ Y + S I ++S++ AE+SG + DR++
Sbjct: 682 PEVKI--VELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVS 739
Query: 251 VDGISLADKSNPQSVEILR 269
V+ L + S ++VEIL+
Sbjct: 740 VNEYCLDNTSLAEAVEILK 758
Score = 40.3 bits (90), Expect = 0.021
Identities = 16/56 (28%), Positives = 32/56 (57%)
Query: 417 IRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARN 472
+R+++P G G L GD +L++ + G+T +V +L+ + VR++ AR+
Sbjct: 272 VRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARD 327
Score = 39.5 bits (88), Expect = 0.037
Identities = 25/87 (28%), Positives = 47/87 (54%), Gaps = 2/87 (2%)
Query: 195 EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGI 254
E+ ++L K+ GLG+++AG ++ +S IFV I A G+++I D ++E++
Sbjct: 1236 ELHIIELEKDKNGLGLSLAGNK-DRSRMS-IFVVGINPEGPAAADGRMRIGDELLEINNQ 1293
Query: 255 SLADKSNPQSVEILRNTGISVHLVLER 281
L +S+ + I++ V LV R
Sbjct: 1294 ILYGRSHQNASAIIKTAPSKVKLVFIR 1320
Score = 38.3 bits (85), Expect = 0.085
Identities = 25/93 (26%), Positives = 49/93 (52%), Gaps = 8/93 (8%)
Query: 7 WA-QVEVVELTNDGNGLGFNLVGGRS------TGVVIKYVLPGGVADKDRRLQSGDHVLQ 59
W+ +V++VEL D GLGF+++ + + +VI+ ++ GVA++ L GD ++
Sbjct: 680 WSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVS 739
Query: 60 VGSVNLRGFTSEQVAAVLRQAGP-VVRLLVARP 91
V L + + +L+ P +V L + +P
Sbjct: 740 VNEYCLDNTSLAEAVEILKAVPPGLVHLGICKP 772
>AL136458-3|CAI21737.1| 1801|Homo sapiens InaD-like (Drosophila)
protein.
Length = 1801
Score = 126 bits (303), Expect = 3e-28
Identities = 99/316 (31%), Positives = 152/316 (48%), Gaps = 25/316 (7%)
Query: 178 SVSPTITITVPVELPEI------------EIIHVDL-NKNVYGLGITVAGYVCEKE--EL 222
SV+P +PV LP + E +V+L K+ LGI + GYV E
Sbjct: 333 SVTPPAPAALPVALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEA 392
Query: 223 SGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLERY 282
SGI+VKSII GS+A +G I++ND+I+ VDG+++ +N VE+LRN G VHL L R
Sbjct: 393 SGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRR 452
Query: 283 LRGPKFEHLQLAIFNEERXXXXXXXXXXLSW-FPVPSQLENSITEIEPEPESNTTIDSSV 341
L+ L+ + ++ EI+ ++ +
Sbjct: 453 KTSSSTSPLEPPSDRGTVVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQA 512
Query: 342 LE-VGDLQEPTQEELDQRFDEILAVDKEDIVKKWKEEIGSDKEI-LVAEIKKLEGLGISL 399
LE + + + + EL R++ +L D E +V +I D E+ +++ + L + +
Sbjct: 513 LEKLEKVPDSPENELKSRWENLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGV 572
Query: 400 EGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILK 459
E VD G HHYI S++ GPV G+L DELLEVN +L+G + E V+ LK
Sbjct: 573 E--VDSFDG-----HHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLK 625
Query: 460 QLPDRVRLVCARNSID 475
++P LVC R D
Sbjct: 626 EVPPPFTLVCCRRLFD 641
Score = 125 bits (302), Expect = 4e-28
Identities = 57/106 (53%), Positives = 78/106 (73%), Gaps = 2/106 (1%)
Query: 7 WAQVEVVELTNDGNGLGFNLVGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLR 66
W VE VEL NDG+GLGF +VGG+++GVV++ ++PGG+AD+D RLQ+GDH+L++G N++
Sbjct: 243 WGHVEEVELINDGSGLGFGIVGGKTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQ 302
Query: 67 GFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVPTKI 112
G TSEQVA VLR G VR+LVAR DPA + P A +P +
Sbjct: 303 GMTSEQVAQVLRNCGNSVRMLVAR--DPAGDISVTPPAPAALPVAL 346
Score = 114 bits (274), Expect = 1e-24
Identities = 55/105 (52%), Positives = 74/105 (70%)
Query: 543 LAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDR 602
LA+W + IV LVK +GLGFSILDYQDP+DP +VIV+RSLV GVAE++G + PGDR
Sbjct: 677 LALWSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDR 736
Query: 603 VMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPLPPQDSSKS 647
++SVN + N +L +AV+ LK P G V +GI +PL + +S
Sbjct: 737 LVSVNEYCLDNTSLAEAVEILKAVPPGLVHLGICKPLVEDNEEES 781
Score = 89.4 bits (212), Expect = 3e-17
Identities = 72/275 (26%), Positives = 127/275 (46%), Gaps = 29/275 (10%)
Query: 198 HVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLA 257
+V L ++ G G TV + EEL GIF+K ++E S A ++ +K D+I+EV G+ L
Sbjct: 1076 NVSLGISIVG-GQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQ 1134
Query: 258 DKSNPQSVEILRNTGISVHLVLERYLRGPKFEHLQLAIFNEERXXXXXXXXXXLSWFPVP 317
+ S+ ++VE ++N G V +++ P+ I N
Sbjct: 1135 NASHSEAVEAIKNAGNPVVFIVQSLSSTPR------VIPNVHNKANKITGN--------- 1179
Query: 318 SQLENSITEIEPEPESNTTIDSSVLEVGDLQEPTQEELDQRFDEILAVDKEDIVKKWKEE 377
+N T+ + E T +++ + ++ D+ +E D++ +++ +
Sbjct: 1180 ---QNQDTQEKKEKRQGTA--PPPMKLPPPYKALTDDSDENEEEDAFTDQK--IRQRYAD 1232
Query: 378 IGSDKEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDE 437
+ + I+ E K GLG+SL G D R ++ + P+GP G + GDE
Sbjct: 1233 LPGELHIIELE-KDKNGLGLSLAGNKD-----RSRMSIFVVGINPEGPAAADGRMRIGDE 1286
Query: 438 LLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARN 472
LLE+N L+G +H I+K P +V+LV RN
Sbjct: 1287 LLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRN 1321
Score = 72.5 bits (170), Expect = 4e-12
Identities = 64/287 (22%), Positives = 134/287 (46%), Gaps = 18/287 (6%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTGVVIKYVL---PGGVADKDRRLQSGDHVLQVGSVNL 65
++ ++EL D NGLG +L G + + +V+ P G A D R++ GD +L++ + L
Sbjct: 1236 ELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQIL 1295
Query: 66 RGFTSEQVAAVLRQAGPVVRLLVARPADPATALRA---PQPGTALVPTKILADPELLDRH 122
G + + +A+++ A V+L+ R D + P P ++ + + E +
Sbjct: 1296 YGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSE 1355
Query: 123 ---LIETGYGAVYDLSQC-YSDYNINGQNGETETSIVAAAVSVIGDNPQKIPDHPIV-CD 177
+E G + + + + Q T+ S + + + + D
Sbjct: 1356 EDGSVEVGIKQLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYG 1415
Query: 178 SVSPTITI---TVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGS 234
+++ T P+ +P E+I ++++K GLG+++ G + L+ I + + E
Sbjct: 1416 GFQAPLSVDPATCPI-VPGQEMI-IEISKGRSGLGLSIVGG--KDTPLNAIVIHEVYEEG 1471
Query: 235 SAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
+A + G++ D+I+EV+G+ L + S+ +++ LR T V LV+ R
Sbjct: 1472 AAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYR 1518
Score = 71.3 bits (167), Expect = 1e-11
Identities = 80/291 (27%), Positives = 126/291 (43%), Gaps = 37/291 (12%)
Query: 13 VELTN-DGNGLGFNLVG-------GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
VEL DG LG +VG G ++G+ +K ++PG A + +Q D ++ V VN
Sbjct: 366 VELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVN 425
Query: 65 LRGFTSEQVAAVLRQAGPVVRL-LVARPADPATA-LRAPQP-GTALVPTKILADPELLDR 121
++GF + V VLR AG VV L LV R +T+ L P GT + P K P L
Sbjct: 426 IQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLK---PPALFLT 482
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIG--DNPQKIPDHP------ 173
+ET + N++G++ E + I I + +K+PD P
Sbjct: 483 GAVET-------------ETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKS 529
Query: 174 IVCDSVSPTITITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSG-IFVKSIIE 232
+ + P + V +I +L K L I E + G ++ SI+
Sbjct: 530 RWENLLGPDYEVMVATLDTQI-ADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVS 588
Query: 233 GSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLERYL 283
G + G ++ D ++EV+G+ L KS ++V L+ LV R L
Sbjct: 589 GGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRL 639
Score = 59.3 bits (137), Expect = 4e-08
Identities = 65/245 (26%), Positives = 109/245 (44%), Gaps = 24/245 (9%)
Query: 395 LGISLEGTVDV----EGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLT 450
LGIS+ G V + G+EL+ +I+ VL D P G L GD++LEV+ L +
Sbjct: 1079 LGISIVGGQTVIKRLKNGEELKGI-FIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNAS 1137
Query: 451 HSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKA 510
HSE V +K + V + S+ S PR + N+ + +A K I+G+ N T K
Sbjct: 1138 HSEAVEAIKNAGNPVVFIV--QSLSSTPRVIPNVHN-----KANK-ITGNQNQDTQEKKE 1189
Query: 511 QSDTSINTSST-----ATLTNHSEQSKKSRSL---ECVSGLAMWQSKEDIVMLVKADQGL 562
+ + LT+ S+++++ + + A + I+ L K GL
Sbjct: 1190 KRQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGL 1249
Query: 563 GFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQA 622
G S+ + D + I V + P G A +G + GD ++ +N + + A
Sbjct: 1250 GLSLAGNK---DRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAI 1306
Query: 623 LKGAP 627
+K AP
Sbjct: 1307 IKTAP 1311
Score = 57.6 bits (133), Expect = 1e-07
Identities = 30/73 (41%), Positives = 45/73 (61%), Gaps = 1/73 (1%)
Query: 19 GNGLGFNLVGGRS-TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAVL 77
G GLG ++VG R+ +GV I ++ GG AD D RL GD +L V ++R + E VA +L
Sbjct: 1541 GRGLGLSIVGKRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATIL 1600
Query: 78 RQAGPVVRLLVAR 90
+ A +V+L + R
Sbjct: 1601 KCAQGLVQLEIGR 1613
Score = 55.2 bits (127), Expect = 7e-07
Identities = 30/92 (32%), Positives = 52/92 (56%), Gaps = 8/92 (8%)
Query: 546 WQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMS 605
W E+ V L+ GLGF I V + +VVR++VPGG+A+++G + GD ++
Sbjct: 243 WGHVEE-VELINDGSGLGFGI------VGGKTSGVVVRTIVPGGLADRDGRLQTGDHILK 295
Query: 606 VNGVSIQNATLDQAVQALKGAPRGTVKVGIAR 637
+ G ++Q T +Q Q L+ +V++ +AR
Sbjct: 296 IGGTNVQGMTSEQVAQVLRNC-GNSVRMLVAR 326
Score = 52.4 bits (120), Expect = 5e-06
Identities = 31/89 (34%), Positives = 51/89 (57%), Gaps = 7/89 (7%)
Query: 9 QVEVVELTNDGNG-LGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDHVLQVGS 62
Q+E +++ G LGF++V RS + +K V PG VAD+D+RL+ D +L +
Sbjct: 131 QIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINH 190
Query: 63 VNL-RGFTSEQVAAVLRQAGPVVRLLVAR 90
L + + +Q A+L+Q +RL+VAR
Sbjct: 191 TPLDQNISHQQAIALLQQTTGSLRLIVAR 219
Score = 51.6 bits (118), Expect = 9e-06
Identities = 29/81 (35%), Positives = 49/81 (60%), Gaps = 6/81 (7%)
Query: 557 KADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATL 616
KA +GLG SI+ + NG+ + + +V GG A+ +G + GD+++SVNG ++NA+
Sbjct: 1539 KAGRGLGLSIVGKR-----NGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQ 1593
Query: 617 DQAVQALKGAPRGTVKVGIAR 637
+ LK A +G V++ I R
Sbjct: 1594 ETVATILKCA-QGLVQLEIGR 1613
Score = 50.8 bits (116), Expect = 1e-05
Identities = 26/81 (32%), Positives = 50/81 (61%), Gaps = 5/81 (6%)
Query: 549 KEDIVMLVKADQGLGFSILDYQD-PVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVN 607
+E I+ + K GLG SI+ +D P++ IV+ + G A ++G + GD+++ VN
Sbjct: 1434 QEMIIEISKGRSGLGLSIVGGKDTPLN----AIVIHEVYEEGAAARDGRLWAGDQILEVN 1489
Query: 608 GVSIQNATLDQAVQALKGAPR 628
GV ++N++ ++A+ AL+ P+
Sbjct: 1490 GVDLRNSSHEEAITALRQTPQ 1510
Score = 50.4 bits (115), Expect = 2e-05
Identities = 31/91 (34%), Positives = 46/91 (50%), Gaps = 5/91 (5%)
Query: 382 KEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEV 441
+E+++ K GLG+S+ G D + I V +G G L AGD++LEV
Sbjct: 1434 QEMIIEISKGRSGLGLSIVGGKDTPLNAIV-----IHEVYEEGAAARDGRLWAGDQILEV 1488
Query: 442 NEYRLHGLTHSEVVNILKQLPDRVRLVCARN 472
N L +H E + L+Q P +VRLV R+
Sbjct: 1489 NGVDLRNSSHEEAITALRQTPQKVRLVVYRD 1519
Score = 50.0 bits (114), Expect = 3e-05
Identities = 43/173 (24%), Positives = 75/173 (43%), Gaps = 13/173 (7%)
Query: 194 IEIIHVDLNKNV-YGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVD 252
+EI VDL K GLG+++ G K SG+F+ I++G +A+ G++ D+I+ V+
Sbjct: 1529 LEIFPVDLQKKAGRGLGLSIVG----KRNGSGVFISDIVKGGAADLDGRLIQGDQILSVN 1584
Query: 253 GISLADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHLQLAIFNEERXXXXXXXXXXLS 312
G + + S IL+ V L + R LR + + N + S
Sbjct: 1585 GEDMRNASQETVATILKCAQGLVQLEIGR-LRAGSWTSARTTSQNSQGSQQSAHSSCHPS 1643
Query: 313 WFPVPSQLENSITEIEPEPESNTTIDSSVLEVGDLQEPTQEELDQRFDEILAV 365
+ PV + L+N + + D S G EP E+++ + L +
Sbjct: 1644 FAPVITGLQNLV-------GTKRVSDPSQKNSGTDMEPRTVEINRELSDALGI 1689
Score = 49.6 bits (113), Expect = 3e-05
Identities = 26/96 (27%), Positives = 54/96 (56%), Gaps = 5/96 (5%)
Query: 186 TVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKIN 245
T+P + + V+L + GLG + G + SG+ V++I+ G A++ G+++
Sbjct: 236 TLPETVCWGHVEEVELINDGSGLGFGIVG-----GKTSGVVVRTIVPGGLADRDGRLQTG 290
Query: 246 DRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
D I+++ G ++ ++ Q ++LRN G SV +++ R
Sbjct: 291 DHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVAR 326
Score = 46.0 bits (104), Expect = 4e-04
Identities = 27/76 (35%), Positives = 41/76 (53%), Gaps = 2/76 (2%)
Query: 553 VMLVKAD-QGLGFSILDYQDPVDPN-GTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVS 610
V LV+ D Q LG I+ Y + I V+S++PG A NG I D++++V+GV+
Sbjct: 366 VELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVN 425
Query: 611 IQNATLDQAVQALKGA 626
IQ V+ L+ A
Sbjct: 426 IQGFANHDVVEVLRNA 441
Score = 45.6 bits (103), Expect = 6e-04
Identities = 35/111 (31%), Positives = 50/111 (45%), Gaps = 7/111 (6%)
Query: 352 QEELDQRFDEILAVDKEDIVKKWKEEIGSDKEILVAEIKKLEGLGISLEGTVDVEGGQEL 411
+ E+D D D + + W E+ +V +K +GLG S+ D
Sbjct: 658 ETEVDHNMDVNTEEDDDGELALWSPEVK-----IVELVKDCKGLGFSILDYQDPL--DPT 710
Query: 412 RPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP 462
R IRS++ DG G L GD L+ VNEY L + +E V ILK +P
Sbjct: 711 RSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAVP 761
Score = 44.4 bits (100), Expect = 0.001
Identities = 58/257 (22%), Positives = 99/257 (38%), Gaps = 24/257 (9%)
Query: 393 EGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHS 452
+ LGI + G V E Y++S++P G + D+++ V+ + G +
Sbjct: 374 QSLGIRIVGYVGTSHTGEASGI-YVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANH 432
Query: 453 EVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARK----IISGSLNNLTTL- 507
+VV +L+ V L R S P+ + E K ++G++ T +
Sbjct: 433 DVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLKPPALFLTGAVETETNVD 492
Query: 508 -----VKAQSDTSINTSSTA-----TLTNHSEQSKKSR-------SLECVSGLAMWQSKE 550
+K + DT N + A + + E KSR E + Q +
Sbjct: 493 GEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDYEVMVATLDTQIAD 552
Query: 551 DIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVS 610
D L K + L L VD + S+V GG + G + P D ++ VNG+
Sbjct: 553 D-AELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQ 611
Query: 611 IQNATLDQAVQALKGAP 627
+ + +AV LK P
Sbjct: 612 LYGKSRREAVSFLKEVP 628
Score = 43.6 bits (98), Expect = 0.002
Identities = 32/123 (26%), Positives = 59/123 (47%), Gaps = 6/123 (4%)
Query: 509 KAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILD 568
KA + T + +S AT T + ++ E + W + + + + LG SI+
Sbjct: 1027 KASAYTGMLSSRYATDTCELPEREEGEGEE-TPNFSHWGPPRIVEIFREPNVSLGISIVG 1085
Query: 569 YQDPVD--PNGTV---IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQAL 623
Q + NG I ++ ++ A K + GD+++ V+GV +QNA+ +AV+A+
Sbjct: 1086 GQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAI 1145
Query: 624 KGA 626
K A
Sbjct: 1146 KNA 1148
Score = 41.9 bits (94), Expect = 0.007
Identities = 25/89 (28%), Positives = 50/89 (56%), Gaps = 2/89 (2%)
Query: 195 EIIHVDLNK-NVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDG 253
+I ++D+ + + GLG +V + IFVK + GS A++ ++K ND+I+ ++
Sbjct: 131 QIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINH 190
Query: 254 ISLADK-SNPQSVEILRNTGISVHLVLER 281
L S+ Q++ +L+ T S+ L++ R
Sbjct: 191 TPLDQNISHQQAIALLQQTTGSLRLIVAR 219
Score = 41.5 bits (93), Expect = 0.009
Identities = 26/79 (32%), Positives = 46/79 (58%), Gaps = 3/79 (3%)
Query: 192 PEIEIIHVDLNKNVYGLGITVAGYVCEKEEL-SGIFVKSIIEGSSAEQSGKIKINDRIIE 250
PE++I V+L K+ GLG ++ Y + S I ++S++ AE+SG + DR++
Sbjct: 682 PEVKI--VELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVS 739
Query: 251 VDGISLADKSNPQSVEILR 269
V+ L + S ++VEIL+
Sbjct: 740 VNEYCLDNTSLAEAVEILK 758
Score = 40.3 bits (90), Expect = 0.021
Identities = 16/56 (28%), Positives = 32/56 (57%)
Query: 417 IRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARN 472
+R+++P G G L GD +L++ + G+T +V +L+ + VR++ AR+
Sbjct: 272 VRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARD 327
Score = 39.1 bits (87), Expect = 0.049
Identities = 32/111 (28%), Positives = 52/111 (46%), Gaps = 6/111 (5%)
Query: 379 GSDKEILVAEIKK--LEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGD 436
G+D E EI + + LGIS+ G G +I + G L GD
Sbjct: 1669 GTDMEPRTVEINRELSDALGISIAGG---RGSPLGDIPVFIAMIQASGVAARTQKLKVGD 1725
Query: 437 ELLEVNEYRLHGLTHSEVVNILKQLPDRVRL-VCARNSIDSGPRPVVNLAS 486
++ +N L GL+H++VVN+LK R+ L V A +I + + N+++
Sbjct: 1726 RIVSINGQPLDGLSHADVVNLLKNAYGRIILQVVADTNISAIAAQLENMST 1776
Score = 38.3 bits (85), Expect = 0.085
Identities = 25/93 (26%), Positives = 49/93 (52%), Gaps = 8/93 (8%)
Query: 7 WA-QVEVVELTNDGNGLGFNLVGGRS------TGVVIKYVLPGGVADKDRRLQSGDHVLQ 59
W+ +V++VEL D GLGF+++ + + +VI+ ++ GVA++ L GD ++
Sbjct: 680 WSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVS 739
Query: 60 VGSVNLRGFTSEQVAAVLRQAGP-VVRLLVARP 91
V L + + +L+ P +V L + +P
Sbjct: 740 VNEYCLDNTSLAEAVEILKAVPPGLVHLGICKP 772
Score = 37.1 bits (82), Expect = 0.20
Identities = 53/245 (21%), Positives = 94/245 (38%), Gaps = 25/245 (10%)
Query: 383 EILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVN 442
EI +++K G G+ L V G + +I ++ G L G L GD++L VN
Sbjct: 1530 EIFPVDLQKKAGRGLGLS-IVGKRNGSGV----FISDIVKGGAADLDGRLIQGDQILSVN 1584
Query: 443 EYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLN 502
+ + V ILK V+L R + +G S + S
Sbjct: 1585 GEDMRNASQETVATILKCAQGLVQLEIGR--LRAGSWTSARTTSQNSQGSQQSAHSSCHP 1642
Query: 503 NLTTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGL 562
+ ++ N T +++ S+++ SG M + + + L
Sbjct: 1643 SFAPVITGLQ----NLVGTKRVSDPSQKN---------SGTDM--EPRTVEINRELSDAL 1687
Query: 563 GFSILDYQDPVDPNGTV-IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQ 621
G SI + P G + + + + GVA + ++ GDR++S+NG + + V
Sbjct: 1688 GISIAGGRG--SPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVN 1745
Query: 622 ALKGA 626
LK A
Sbjct: 1746 LLKNA 1750
Score = 35.5 bits (78), Expect = 0.60
Identities = 21/73 (28%), Positives = 39/73 (53%), Gaps = 1/73 (1%)
Query: 199 VDLNKNVY-GLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLA 257
V++N+ + LGI++AG +F+ I A ++ K+K+ DRI+ ++G L
Sbjct: 1677 VEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLD 1736
Query: 258 DKSNPQSVEILRN 270
S+ V +L+N
Sbjct: 1737 GLSHADVVNLLKN 1749
Score = 34.7 bits (76), Expect = 1.0
Identities = 23/84 (27%), Positives = 43/84 (51%), Gaps = 7/84 (8%)
Query: 13 VELTND-GNGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLR 66
VE+ + + LG ++ GGR + V I + GVA + ++L+ GD ++ + L
Sbjct: 1677 VEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLD 1736
Query: 67 GFTSEQVAAVLRQA-GPVVRLLVA 89
G + V +L+ A G ++ +VA
Sbjct: 1737 GLSHADVVNLLKNAYGRIILQVVA 1760
>AL136458-2|CAI21734.1| 1582|Homo sapiens InaD-like (Drosophila)
protein.
Length = 1582
Score = 126 bits (303), Expect = 3e-28
Identities = 99/316 (31%), Positives = 152/316 (48%), Gaps = 25/316 (7%)
Query: 178 SVSPTITITVPVELPEI------------EIIHVDL-NKNVYGLGITVAGYVCEKE--EL 222
SV+P +PV LP + E +V+L K+ LGI + GYV E
Sbjct: 333 SVTPPAPAALPVALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEA 392
Query: 223 SGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLERY 282
SGI+VKSII GS+A +G I++ND+I+ VDG+++ +N VE+LRN G VHL L R
Sbjct: 393 SGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRR 452
Query: 283 LRGPKFEHLQLAIFNEERXXXXXXXXXXLSW-FPVPSQLENSITEIEPEPESNTTIDSSV 341
L+ L+ + ++ EI+ ++ +
Sbjct: 453 KTSSSTSPLEPPSDRGTVVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQA 512
Query: 342 LE-VGDLQEPTQEELDQRFDEILAVDKEDIVKKWKEEIGSDKEI-LVAEIKKLEGLGISL 399
LE + + + + EL R++ +L D E +V +I D E+ +++ + L + +
Sbjct: 513 LEKLEKVPDSPENELKSRWENLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGV 572
Query: 400 EGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILK 459
E VD G HHYI S++ GPV G+L DELLEVN +L+G + E V+ LK
Sbjct: 573 E--VDSFDG-----HHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLK 625
Query: 460 QLPDRVRLVCARNSID 475
++P LVC R D
Sbjct: 626 EVPPPFTLVCCRRLFD 641
Score = 125 bits (302), Expect = 4e-28
Identities = 57/106 (53%), Positives = 78/106 (73%), Gaps = 2/106 (1%)
Query: 7 WAQVEVVELTNDGNGLGFNLVGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLR 66
W VE VEL NDG+GLGF +VGG+++GVV++ ++PGG+AD+D RLQ+GDH+L++G N++
Sbjct: 243 WGHVEEVELINDGSGLGFGIVGGKTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQ 302
Query: 67 GFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVPTKI 112
G TSEQVA VLR G VR+LVAR DPA + P A +P +
Sbjct: 303 GMTSEQVAQVLRNCGNSVRMLVAR--DPAGDISVTPPAPAALPVAL 346
Score = 114 bits (274), Expect = 1e-24
Identities = 55/105 (52%), Positives = 74/105 (70%)
Query: 543 LAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDR 602
LA+W + IV LVK +GLGFSILDYQDP+DP +VIV+RSLV GVAE++G + PGDR
Sbjct: 677 LALWSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDR 736
Query: 603 VMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPLPPQDSSKS 647
++SVN + N +L +AV+ LK P G V +GI +PL + +S
Sbjct: 737 LVSVNEYCLDNTSLAEAVEILKAVPPGLVHLGICKPLVEDNEEES 781
Score = 89.4 bits (212), Expect = 3e-17
Identities = 72/275 (26%), Positives = 127/275 (46%), Gaps = 29/275 (10%)
Query: 198 HVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLA 257
+V L ++ G G TV + EEL GIF+K ++E S A ++ +K D+I+EV G+ L
Sbjct: 1076 NVSLGISIVG-GQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQ 1134
Query: 258 DKSNPQSVEILRNTGISVHLVLERYLRGPKFEHLQLAIFNEERXXXXXXXXXXLSWFPVP 317
+ S+ ++VE ++N G V +++ P+ I N
Sbjct: 1135 NASHSEAVEAIKNAGNPVVFIVQSLSSTPR------VIPNVHNKANKITGN--------- 1179
Query: 318 SQLENSITEIEPEPESNTTIDSSVLEVGDLQEPTQEELDQRFDEILAVDKEDIVKKWKEE 377
+N T+ + E T +++ + ++ D+ +E D++ +++ +
Sbjct: 1180 ---QNQDTQEKKEKRQGTA--PPPMKLPPPYKALTDDSDENEEEDAFTDQK--IRQRYAD 1232
Query: 378 IGSDKEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDE 437
+ + I+ E K GLG+SL G D R ++ + P+GP G + GDE
Sbjct: 1233 LPGELHIIELE-KDKNGLGLSLAGNKD-----RSRMSIFVVGINPEGPAAADGRMRIGDE 1286
Query: 438 LLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARN 472
LLE+N L+G +H I+K P +V+LV RN
Sbjct: 1287 LLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRN 1321
Score = 71.3 bits (167), Expect = 1e-11
Identities = 80/291 (27%), Positives = 126/291 (43%), Gaps = 37/291 (12%)
Query: 13 VELTN-DGNGLGFNLVG-------GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
VEL DG LG +VG G ++G+ +K ++PG A + +Q D ++ V VN
Sbjct: 366 VELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVN 425
Query: 65 LRGFTSEQVAAVLRQAGPVVRL-LVARPADPATA-LRAPQP-GTALVPTKILADPELLDR 121
++GF + V VLR AG VV L LV R +T+ L P GT + P K P L
Sbjct: 426 IQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLK---PPALFLT 482
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIG--DNPQKIPDHP------ 173
+ET + N++G++ E + I I + +K+PD P
Sbjct: 483 GAVET-------------ETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKS 529
Query: 174 IVCDSVSPTITITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSG-IFVKSIIE 232
+ + P + V +I +L K L I E + G ++ SI+
Sbjct: 530 RWENLLGPDYEVMVATLDTQI-ADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVS 588
Query: 233 GSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLERYL 283
G + G ++ D ++EV+G+ L KS ++V L+ LV R L
Sbjct: 589 GGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRL 639
Score = 59.3 bits (137), Expect = 4e-08
Identities = 65/245 (26%), Positives = 109/245 (44%), Gaps = 24/245 (9%)
Query: 395 LGISLEGTVDV----EGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLT 450
LGIS+ G V + G+EL+ +I+ VL D P G L GD++LEV+ L +
Sbjct: 1079 LGISIVGGQTVIKRLKNGEELKGI-FIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNAS 1137
Query: 451 HSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKA 510
HSE V +K + V + S+ S PR + N+ + +A K I+G+ N T K
Sbjct: 1138 HSEAVEAIKNAGNPVVFIV--QSLSSTPRVIPNVHN-----KANK-ITGNQNQDTQEKKE 1189
Query: 511 QSDTSINTSST-----ATLTNHSEQSKKSRSL---ECVSGLAMWQSKEDIVMLVKADQGL 562
+ + LT+ S+++++ + + A + I+ L K GL
Sbjct: 1190 KRQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGL 1249
Query: 563 GFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQA 622
G S+ + D + I V + P G A +G + GD ++ +N + + A
Sbjct: 1250 GLSLAGNK---DRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAI 1306
Query: 623 LKGAP 627
+K AP
Sbjct: 1307 IKTAP 1311
Score = 55.2 bits (127), Expect = 7e-07
Identities = 30/92 (32%), Positives = 52/92 (56%), Gaps = 8/92 (8%)
Query: 546 WQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMS 605
W E+ V L+ GLGF I V + +VVR++VPGG+A+++G + GD ++
Sbjct: 243 WGHVEE-VELINDGSGLGFGI------VGGKTSGVVVRTIVPGGLADRDGRLQTGDHILK 295
Query: 606 VNGVSIQNATLDQAVQALKGAPRGTVKVGIAR 637
+ G ++Q T +Q Q L+ +V++ +AR
Sbjct: 296 IGGTNVQGMTSEQVAQVLRNC-GNSVRMLVAR 326
Score = 52.4 bits (120), Expect = 5e-06
Identities = 31/89 (34%), Positives = 51/89 (57%), Gaps = 7/89 (7%)
Query: 9 QVEVVELTNDGNG-LGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDHVLQVGS 62
Q+E +++ G LGF++V RS + +K V PG VAD+D+RL+ D +L +
Sbjct: 131 QIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINH 190
Query: 63 VNL-RGFTSEQVAAVLRQAGPVVRLLVAR 90
L + + +Q A+L+Q +RL+VAR
Sbjct: 191 TPLDQNISHQQAIALLQQTTGSLRLIVAR 219
Score = 51.2 bits (117), Expect = 1e-05
Identities = 30/108 (27%), Positives = 56/108 (51%), Gaps = 4/108 (3%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTGVVIKYVL---PGGVADKDRRLQSGDHVLQVGSVNL 65
++ ++EL D NGLG +L G + + +V+ P G A D R++ GD +L++ + L
Sbjct: 1236 ELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQIL 1295
Query: 66 RGFTSEQVAAVLRQAGPVVRLLVARPADPATALR-APQPGTALVPTKI 112
G + + +A+++ A V+L+ R D + P P + P+ I
Sbjct: 1296 YGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSI 1343
Score = 49.6 bits (113), Expect = 3e-05
Identities = 26/96 (27%), Positives = 54/96 (56%), Gaps = 5/96 (5%)
Query: 186 TVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKIN 245
T+P + + V+L + GLG + G + SG+ V++I+ G A++ G+++
Sbjct: 236 TLPETVCWGHVEEVELINDGSGLGFGIVG-----GKTSGVVVRTIVPGGLADRDGRLQTG 290
Query: 246 DRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
D I+++ G ++ ++ Q ++LRN G SV +++ R
Sbjct: 291 DHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVAR 326
Score = 46.4 bits (105), Expect = 3e-04
Identities = 23/56 (41%), Positives = 31/56 (55%)
Query: 417 IRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARN 472
I V +G G L AGD++LEVN L +H E + L+Q P +VRLV R+
Sbjct: 1494 IHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRD 1549
Score = 46.0 bits (104), Expect = 4e-04
Identities = 27/76 (35%), Positives = 41/76 (53%), Gaps = 2/76 (2%)
Query: 553 VMLVKAD-QGLGFSILDYQDPVDPN-GTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVS 610
V LV+ D Q LG I+ Y + I V+S++PG A NG I D++++V+GV+
Sbjct: 366 VELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVN 425
Query: 611 IQNATLDQAVQALKGA 626
IQ V+ L+ A
Sbjct: 426 IQGFANHDVVEVLRNA 441
Score = 45.6 bits (103), Expect = 6e-04
Identities = 35/111 (31%), Positives = 50/111 (45%), Gaps = 7/111 (6%)
Query: 352 QEELDQRFDEILAVDKEDIVKKWKEEIGSDKEILVAEIKKLEGLGISLEGTVDVEGGQEL 411
+ E+D D D + + W E+ +V +K +GLG S+ D
Sbjct: 658 ETEVDHNMDVNTEEDDDGELALWSPEVK-----IVELVKDCKGLGFSILDYQDPL--DPT 710
Query: 412 RPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP 462
R IRS++ DG G L GD L+ VNEY L + +E V ILK +P
Sbjct: 711 RSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAVP 761
Score = 45.6 bits (103), Expect = 6e-04
Identities = 24/57 (42%), Positives = 33/57 (57%)
Query: 34 VVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVAR 90
+VI V G A +D RL +GD +L+V V+LR + E+ LRQ VRL+V R
Sbjct: 1492 IVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYR 1548
Score = 44.4 bits (100), Expect = 0.001
Identities = 58/257 (22%), Positives = 99/257 (38%), Gaps = 24/257 (9%)
Query: 393 EGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHS 452
+ LGI + G V E Y++S++P G + D+++ V+ + G +
Sbjct: 374 QSLGIRIVGYVGTSHTGEASGI-YVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANH 432
Query: 453 EVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARK----IISGSLNNLTTL- 507
+VV +L+ V L R S P+ + E K ++G++ T +
Sbjct: 433 DVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLKPPALFLTGAVETETNVD 492
Query: 508 -----VKAQSDTSINTSSTA-----TLTNHSEQSKKSR-------SLECVSGLAMWQSKE 550
+K + DT N + A + + E KSR E + Q +
Sbjct: 493 GEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDYEVMVATLDTQIAD 552
Query: 551 DIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVS 610
D L K + L L VD + S+V GG + G + P D ++ VNG+
Sbjct: 553 D-AELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQ 611
Query: 611 IQNATLDQAVQALKGAP 627
+ + +AV LK P
Sbjct: 612 LYGKSRREAVSFLKEVP 628
Score = 43.6 bits (98), Expect = 0.002
Identities = 32/123 (26%), Positives = 59/123 (47%), Gaps = 6/123 (4%)
Query: 509 KAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILD 568
KA + T + +S AT T + ++ E + W + + + + LG SI+
Sbjct: 1027 KASAYTGMLSSRYATDTCELPEREEGEGEE-TPNFSHWGPPRIVEIFREPNVSLGISIVG 1085
Query: 569 YQDPVD--PNGTV---IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQAL 623
Q + NG I ++ ++ A K + GD+++ V+GV +QNA+ +AV+A+
Sbjct: 1086 GQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAI 1145
Query: 624 KGA 626
K A
Sbjct: 1146 KNA 1148
Score = 43.6 bits (98), Expect = 0.002
Identities = 21/66 (31%), Positives = 38/66 (57%)
Query: 216 VCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISV 275
V E E + I + + E +A + G++ D+I+EV+G+ L + S+ +++ LR T V
Sbjct: 1483 VTEVEGQNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKV 1542
Query: 276 HLVLER 281
LV+ R
Sbjct: 1543 RLVVYR 1548
Score = 42.7 bits (96), Expect = 0.004
Identities = 16/49 (32%), Positives = 33/49 (67%)
Query: 580 IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPR 628
IV+ + G A ++G + GD+++ VNGV ++N++ ++A+ AL+ P+
Sbjct: 1492 IVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQ 1540
Score = 41.9 bits (94), Expect = 0.007
Identities = 25/89 (28%), Positives = 50/89 (56%), Gaps = 2/89 (2%)
Query: 195 EIIHVDLNK-NVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDG 253
+I ++D+ + + GLG +V + IFVK + GS A++ ++K ND+I+ ++
Sbjct: 131 QIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINH 190
Query: 254 ISLADK-SNPQSVEILRNTGISVHLVLER 281
L S+ Q++ +L+ T S+ L++ R
Sbjct: 191 TPLDQNISHQQAIALLQQTTGSLRLIVAR 219
Score = 41.5 bits (93), Expect = 0.009
Identities = 26/79 (32%), Positives = 46/79 (58%), Gaps = 3/79 (3%)
Query: 192 PEIEIIHVDLNKNVYGLGITVAGYVCEKEEL-SGIFVKSIIEGSSAEQSGKIKINDRIIE 250
PE++I V+L K+ GLG ++ Y + S I ++S++ AE+SG + DR++
Sbjct: 682 PEVKI--VELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVS 739
Query: 251 VDGISLADKSNPQSVEILR 269
V+ L + S ++VEIL+
Sbjct: 740 VNEYCLDNTSLAEAVEILK 758
Score = 40.3 bits (90), Expect = 0.021
Identities = 16/56 (28%), Positives = 32/56 (57%)
Query: 417 IRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARN 472
+R+++P G G L GD +L++ + G+T +V +L+ + VR++ AR+
Sbjct: 272 VRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARD 327
Score = 39.5 bits (88), Expect = 0.037
Identities = 25/87 (28%), Positives = 47/87 (54%), Gaps = 2/87 (2%)
Query: 195 EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGI 254
E+ ++L K+ GLG+++AG ++ +S IFV I A G+++I D ++E++
Sbjct: 1236 ELHIIELEKDKNGLGLSLAGNK-DRSRMS-IFVVGINPEGPAAADGRMRIGDELLEINNQ 1293
Query: 255 SLADKSNPQSVEILRNTGISVHLVLER 281
L +S+ + I++ V LV R
Sbjct: 1294 ILYGRSHQNASAIIKTAPSKVKLVFIR 1320
Score = 38.3 bits (85), Expect = 0.085
Identities = 25/93 (26%), Positives = 49/93 (52%), Gaps = 8/93 (8%)
Query: 7 WA-QVEVVELTNDGNGLGFNLVGGRS------TGVVIKYVLPGGVADKDRRLQSGDHVLQ 59
W+ +V++VEL D GLGF+++ + + +VI+ ++ GVA++ L GD ++
Sbjct: 680 WSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVS 739
Query: 60 VGSVNLRGFTSEQVAAVLRQAGP-VVRLLVARP 91
V L + + +L+ P +V L + +P
Sbjct: 740 VNEYCLDNTSLAEAVEILKAVPPGLVHLGICKP 772
>AJ224748-1|CAA12113.1| 1582|Homo sapiens Inadl protein.
Length = 1582
Score = 126 bits (303), Expect = 3e-28
Identities = 99/316 (31%), Positives = 152/316 (48%), Gaps = 25/316 (7%)
Query: 178 SVSPTITITVPVELPEI------------EIIHVDL-NKNVYGLGITVAGYVCEKE--EL 222
SV+P +PV LP + E +V+L K+ LGI + GYV E
Sbjct: 333 SVTPPAPAALPVALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEA 392
Query: 223 SGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLERY 282
SGI+VKSII GS+A +G I++ND+I+ VDG+++ +N VE+LRN G VHL L R
Sbjct: 393 SGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRR 452
Query: 283 LRGPKFEHLQLAIFNEERXXXXXXXXXXLSW-FPVPSQLENSITEIEPEPESNTTIDSSV 341
L+ L+ + ++ EI+ ++ +
Sbjct: 453 KTSSSTSPLEPPSDRGTVVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQA 512
Query: 342 LE-VGDLQEPTQEELDQRFDEILAVDKEDIVKKWKEEIGSDKEI-LVAEIKKLEGLGISL 399
LE + + + + EL R++ +L D E +V +I D E+ +++ + L + +
Sbjct: 513 LEKLEKVPDSPENELKSRWENLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGV 572
Query: 400 EGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILK 459
E VD G HHYI S++ GPV G+L DELLEVN +L+G + E V+ LK
Sbjct: 573 E--VDSFDG-----HHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLK 625
Query: 460 QLPDRVRLVCARNSID 475
++P LVC R D
Sbjct: 626 EVPPPFTLVCCRRLFD 641
Score = 125 bits (302), Expect = 4e-28
Identities = 57/106 (53%), Positives = 78/106 (73%), Gaps = 2/106 (1%)
Query: 7 WAQVEVVELTNDGNGLGFNLVGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLR 66
W VE VEL NDG+GLGF +VGG+++GVV++ ++PGG+AD+D RLQ+GDH+L++G N++
Sbjct: 243 WGHVEEVELINDGSGLGFGIVGGKTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQ 302
Query: 67 GFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVPTKI 112
G TSEQVA VLR G VR+LVAR DPA + P A +P +
Sbjct: 303 GMTSEQVAQVLRNCGNSVRMLVAR--DPAGDISVTPPAPAALPVAL 346
Score = 114 bits (274), Expect = 1e-24
Identities = 55/105 (52%), Positives = 74/105 (70%)
Query: 543 LAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDR 602
LA+W + IV LVK +GLGFSILDYQDP+DP +VIV+RSLV GVAE++G + PGDR
Sbjct: 677 LALWSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDR 736
Query: 603 VMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPLPPQDSSKS 647
++SVN + N +L +AV+ LK P G V +GI +PL + +S
Sbjct: 737 LVSVNEYRLDNTSLAEAVEILKAVPPGLVHLGICKPLVEDNEEES 781
Score = 89.4 bits (212), Expect = 3e-17
Identities = 72/275 (26%), Positives = 127/275 (46%), Gaps = 29/275 (10%)
Query: 198 HVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLA 257
+V L ++ G G TV + EEL GIF+K ++E S A ++ +K D+I+EV G+ L
Sbjct: 1076 NVSLGISIVG-GQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQ 1134
Query: 258 DKSNPQSVEILRNTGISVHLVLERYLRGPKFEHLQLAIFNEERXXXXXXXXXXLSWFPVP 317
+ S+ ++VE ++N G V +++ P+ I N
Sbjct: 1135 NASHSEAVEAIKNAGNPVVFIVQSLSSTPR------VIPNVHNKANKITGN--------- 1179
Query: 318 SQLENSITEIEPEPESNTTIDSSVLEVGDLQEPTQEELDQRFDEILAVDKEDIVKKWKEE 377
+N T+ + E T +++ + ++ D+ +E D++ +++ +
Sbjct: 1180 ---QNQDTQEKKEKRQGTA--PPPMKLPPPYKALTDDSDENEEEDAFTDQK--IRQRYAD 1232
Query: 378 IGSDKEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDE 437
+ + I+ E K GLG+SL G D R ++ + P+GP G + GDE
Sbjct: 1233 LPGELHIIELE-KDKNGLGLSLAGNKD-----RSRMSIFVVGINPEGPAAADGRMRIGDE 1286
Query: 438 LLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARN 472
LLE+N L+G +H I+K P +V+LV RN
Sbjct: 1287 LLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRN 1321
Score = 71.3 bits (167), Expect = 1e-11
Identities = 80/291 (27%), Positives = 126/291 (43%), Gaps = 37/291 (12%)
Query: 13 VELTN-DGNGLGFNLVG-------GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
VEL DG LG +VG G ++G+ +K ++PG A + +Q D ++ V VN
Sbjct: 366 VELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVN 425
Query: 65 LRGFTSEQVAAVLRQAGPVVRL-LVARPADPATA-LRAPQP-GTALVPTKILADPELLDR 121
++GF + V VLR AG VV L LV R +T+ L P GT + P K P L
Sbjct: 426 IQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLK---PPALFLT 482
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIG--DNPQKIPDHP------ 173
+ET + N++G++ E + I I + +K+PD P
Sbjct: 483 GAVET-------------ETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKS 529
Query: 174 IVCDSVSPTITITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSG-IFVKSIIE 232
+ + P + V +I +L K L I E + G ++ SI+
Sbjct: 530 RWENLLGPDYEVMVATLDTQI-ADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVS 588
Query: 233 GSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLERYL 283
G + G ++ D ++EV+G+ L KS ++V L+ LV R L
Sbjct: 589 GGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRL 639
Score = 59.3 bits (137), Expect = 4e-08
Identities = 65/245 (26%), Positives = 109/245 (44%), Gaps = 24/245 (9%)
Query: 395 LGISLEGTVDV----EGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLT 450
LGIS+ G V + G+EL+ +I+ VL D P G L GD++LEV+ L +
Sbjct: 1079 LGISIVGGQTVIKRLKNGEELKGI-FIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNAS 1137
Query: 451 HSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKA 510
HSE V +K + V + S+ S PR + N+ + +A K I+G+ N T K
Sbjct: 1138 HSEAVEAIKNAGNPVVFIV--QSLSSTPRVIPNVHN-----KANK-ITGNQNQDTQEKKE 1189
Query: 511 QSDTSINTSST-----ATLTNHSEQSKKSRSL---ECVSGLAMWQSKEDIVMLVKADQGL 562
+ + LT+ S+++++ + + A + I+ L K GL
Sbjct: 1190 KRQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGL 1249
Query: 563 GFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQA 622
G S+ + D + I V + P G A +G + GD ++ +N + + A
Sbjct: 1250 GLSLAGNK---DRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAI 1306
Query: 623 LKGAP 627
+K AP
Sbjct: 1307 IKTAP 1311
Score = 55.2 bits (127), Expect = 7e-07
Identities = 30/92 (32%), Positives = 52/92 (56%), Gaps = 8/92 (8%)
Query: 546 WQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMS 605
W E+ V L+ GLGF I V + +VVR++VPGG+A+++G + GD ++
Sbjct: 243 WGHVEE-VELINDGSGLGFGI------VGGKTSGVVVRTIVPGGLADRDGRLQTGDHILK 295
Query: 606 VNGVSIQNATLDQAVQALKGAPRGTVKVGIAR 637
+ G ++Q T +Q Q L+ +V++ +AR
Sbjct: 296 IGGTNVQGMTSEQVAQVLRNC-GNSVRMLVAR 326
Score = 52.4 bits (120), Expect = 5e-06
Identities = 31/89 (34%), Positives = 51/89 (57%), Gaps = 7/89 (7%)
Query: 9 QVEVVELTNDGNG-LGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDHVLQVGS 62
Q+E +++ G LGF++V RS + +K V PG VAD+D+RL+ D +L +
Sbjct: 131 QIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINH 190
Query: 63 VNL-RGFTSEQVAAVLRQAGPVVRLLVAR 90
L + + +Q A+L+Q +RL+VAR
Sbjct: 191 TPLDQNISHQQAIALLQQTTGSLRLIVAR 219
Score = 51.2 bits (117), Expect = 1e-05
Identities = 30/108 (27%), Positives = 56/108 (51%), Gaps = 4/108 (3%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTGVVIKYVL---PGGVADKDRRLQSGDHVLQVGSVNL 65
++ ++EL D NGLG +L G + + +V+ P G A D R++ GD +L++ + L
Sbjct: 1236 ELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQIL 1295
Query: 66 RGFTSEQVAAVLRQAGPVVRLLVARPADPATALR-APQPGTALVPTKI 112
G + + +A+++ A V+L+ R D + P P + P+ I
Sbjct: 1296 YGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSI 1343
Score = 49.6 bits (113), Expect = 3e-05
Identities = 26/96 (27%), Positives = 54/96 (56%), Gaps = 5/96 (5%)
Query: 186 TVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKIN 245
T+P + + V+L + GLG + G + SG+ V++I+ G A++ G+++
Sbjct: 236 TLPETVCWGHVEEVELINDGSGLGFGIVG-----GKTSGVVVRTIVPGGLADRDGRLQTG 290
Query: 246 DRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
D I+++ G ++ ++ Q ++LRN G SV +++ R
Sbjct: 291 DHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVAR 326
Score = 48.8 bits (111), Expect = 6e-05
Identities = 36/111 (32%), Positives = 51/111 (45%), Gaps = 7/111 (6%)
Query: 352 QEELDQRFDEILAVDKEDIVKKWKEEIGSDKEILVAEIKKLEGLGISLEGTVDVEGGQEL 411
+ E+D D D + + W E+ +V +K +GLG S+ D
Sbjct: 658 ETEVDHNMDVNTEEDDDGELALWSPEVK-----IVELVKDCKGLGFSILDYQDPL--DPT 710
Query: 412 RPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP 462
R IRS++ DG G L GD L+ VNEYRL + +E V ILK +P
Sbjct: 711 RSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYRLDNTSLAEAVEILKAVP 761
Score = 46.4 bits (105), Expect = 3e-04
Identities = 23/56 (41%), Positives = 31/56 (55%)
Query: 417 IRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARN 472
I V +G G L AGD++LEVN L +H E + L+Q P +VRLV R+
Sbjct: 1494 IHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRD 1549
Score = 46.0 bits (104), Expect = 4e-04
Identities = 27/76 (35%), Positives = 41/76 (53%), Gaps = 2/76 (2%)
Query: 553 VMLVKAD-QGLGFSILDYQDPVDPN-GTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVS 610
V LV+ D Q LG I+ Y + I V+S++PG A NG I D++++V+GV+
Sbjct: 366 VELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVN 425
Query: 611 IQNATLDQAVQALKGA 626
IQ V+ L+ A
Sbjct: 426 IQGFANHDVVEVLRNA 441
Score = 45.6 bits (103), Expect = 6e-04
Identities = 24/57 (42%), Positives = 33/57 (57%)
Query: 34 VVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVAR 90
+VI V G A +D RL +GD +L+V V+LR + E+ LRQ VRL+V R
Sbjct: 1492 IVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYR 1548
Score = 44.4 bits (100), Expect = 0.001
Identities = 58/257 (22%), Positives = 99/257 (38%), Gaps = 24/257 (9%)
Query: 393 EGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHS 452
+ LGI + G V E Y++S++P G + D+++ V+ + G +
Sbjct: 374 QSLGIRIVGYVGTSHTGEASGI-YVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANH 432
Query: 453 EVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARK----IISGSLNNLTTL- 507
+VV +L+ V L R S P+ + E K ++G++ T +
Sbjct: 433 DVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLKPPALFLTGAVETETNVD 492
Query: 508 -----VKAQSDTSINTSSTA-----TLTNHSEQSKKSR-------SLECVSGLAMWQSKE 550
+K + DT N + A + + E KSR E + Q +
Sbjct: 493 GEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDYEVMVATLDTQIAD 552
Query: 551 DIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVS 610
D L K + L L VD + S+V GG + G + P D ++ VNG+
Sbjct: 553 D-AELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQ 611
Query: 611 IQNATLDQAVQALKGAP 627
+ + +AV LK P
Sbjct: 612 LYGKSRREAVSFLKEVP 628
Score = 43.6 bits (98), Expect = 0.002
Identities = 32/123 (26%), Positives = 59/123 (47%), Gaps = 6/123 (4%)
Query: 509 KAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILD 568
KA + T + +S AT T + ++ E + W + + + + LG SI+
Sbjct: 1027 KASAYTGMLSSRYATDTCELPEREEGEGEE-TPNFSHWGPPRIVEIFREPNVSLGISIVG 1085
Query: 569 YQDPVD--PNGTV---IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQAL 623
Q + NG I ++ ++ A K + GD+++ V+GV +QNA+ +AV+A+
Sbjct: 1086 GQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAI 1145
Query: 624 KGA 626
K A
Sbjct: 1146 KNA 1148
Score = 43.6 bits (98), Expect = 0.002
Identities = 21/66 (31%), Positives = 38/66 (57%)
Query: 216 VCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISV 275
V E E + I + + E +A + G++ D+I+EV+G+ L + S+ +++ LR T V
Sbjct: 1483 VTEVEGQNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKV 1542
Query: 276 HLVLER 281
LV+ R
Sbjct: 1543 RLVVYR 1548
Score = 42.7 bits (96), Expect = 0.004
Identities = 16/49 (32%), Positives = 33/49 (67%)
Query: 580 IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPR 628
IV+ + G A ++G + GD+++ VNGV ++N++ ++A+ AL+ P+
Sbjct: 1492 IVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQ 1540
Score = 41.9 bits (94), Expect = 0.007
Identities = 25/89 (28%), Positives = 50/89 (56%), Gaps = 2/89 (2%)
Query: 195 EIIHVDLNK-NVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDG 253
+I ++D+ + + GLG +V + IFVK + GS A++ ++K ND+I+ ++
Sbjct: 131 QIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINH 190
Query: 254 ISLADK-SNPQSVEILRNTGISVHLVLER 281
L S+ Q++ +L+ T S+ L++ R
Sbjct: 191 TPLDQNISHQQAIALLQQTTGSLRLIVAR 219
Score = 41.5 bits (93), Expect = 0.009
Identities = 26/79 (32%), Positives = 46/79 (58%), Gaps = 3/79 (3%)
Query: 192 PEIEIIHVDLNKNVYGLGITVAGYVCEKEEL-SGIFVKSIIEGSSAEQSGKIKINDRIIE 250
PE++I V+L K+ GLG ++ Y + S I ++S++ AE+SG + DR++
Sbjct: 682 PEVKI--VELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVS 739
Query: 251 VDGISLADKSNPQSVEILR 269
V+ L + S ++VEIL+
Sbjct: 740 VNEYRLDNTSLAEAVEILK 758
Score = 40.3 bits (90), Expect = 0.021
Identities = 16/56 (28%), Positives = 32/56 (57%)
Query: 417 IRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARN 472
+R+++P G G L GD +L++ + G+T +V +L+ + VR++ AR+
Sbjct: 272 VRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARD 327
Score = 39.5 bits (88), Expect = 0.037
Identities = 25/93 (26%), Positives = 49/93 (52%), Gaps = 8/93 (8%)
Query: 7 WA-QVEVVELTNDGNGLGFNLVGGRS------TGVVIKYVLPGGVADKDRRLQSGDHVLQ 59
W+ +V++VEL D GLGF+++ + + +VI+ ++ GVA++ L GD ++
Sbjct: 680 WSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVS 739
Query: 60 VGSVNLRGFTSEQVAAVLRQAGP-VVRLLVARP 91
V L + + +L+ P +V L + +P
Sbjct: 740 VNEYRLDNTSLAEAVEILKAVPPGLVHLGICKP 772
Score = 39.5 bits (88), Expect = 0.037
Identities = 25/87 (28%), Positives = 47/87 (54%), Gaps = 2/87 (2%)
Query: 195 EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGI 254
E+ ++L K+ GLG+++AG ++ +S IFV I A G+++I D ++E++
Sbjct: 1236 ELHIIELEKDKNGLGLSLAGNK-DRSRMS-IFVVGINPEGPAAADGRMRIGDELLEINNQ 1293
Query: 255 SLADKSNPQSVEILRNTGISVHLVLER 281
L +S+ + I++ V LV R
Sbjct: 1294 ILYGRSHQNASAIIKTAPSKVKLVFIR 1320
>AJ224747-1|CAA12112.1| 1552|Homo sapiens Inadl protein.
Length = 1552
Score = 126 bits (303), Expect = 3e-28
Identities = 99/316 (31%), Positives = 152/316 (48%), Gaps = 25/316 (7%)
Query: 178 SVSPTITITVPVELPEI------------EIIHVDL-NKNVYGLGITVAGYVCEKE--EL 222
SV+P +PV LP + E +V+L K+ LGI + GYV E
Sbjct: 333 SVTPPAPAALPVALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEA 392
Query: 223 SGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLERY 282
SGI+VKSII GS+A +G I++ND+I+ VDG+++ +N VE+LRN G VHL L R
Sbjct: 393 SGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRR 452
Query: 283 LRGPKFEHLQLAIFNEERXXXXXXXXXXLSW-FPVPSQLENSITEIEPEPESNTTIDSSV 341
L+ L+ + ++ EI+ ++ +
Sbjct: 453 KTSSSTSPLEPPSDRGTVVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQA 512
Query: 342 LE-VGDLQEPTQEELDQRFDEILAVDKEDIVKKWKEEIGSDKEI-LVAEIKKLEGLGISL 399
LE + + + + EL R++ +L D E +V +I D E+ +++ + L + +
Sbjct: 513 LEKLEKVPDSPENELKSRWENLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGV 572
Query: 400 EGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILK 459
E VD G HHYI S++ GPV G+L DELLEVN +L+G + E V+ LK
Sbjct: 573 E--VDSFDG-----HHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLK 625
Query: 460 QLPDRVRLVCARNSID 475
++P LVC R D
Sbjct: 626 EVPPPFTLVCCRRLFD 641
Score = 125 bits (302), Expect = 4e-28
Identities = 57/106 (53%), Positives = 78/106 (73%), Gaps = 2/106 (1%)
Query: 7 WAQVEVVELTNDGNGLGFNLVGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLR 66
W VE VEL NDG+GLGF +VGG+++GVV++ ++PGG+AD+D RLQ+GDH+L++G N++
Sbjct: 243 WGHVEEVELINDGSGLGFGIVGGKTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQ 302
Query: 67 GFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVPTKI 112
G TSEQVA VLR G VR+LVAR DPA + P A +P +
Sbjct: 303 GMTSEQVAQVLRNCGNSVRMLVAR--DPAGDISVTPPAPAALPVAL 346
Score = 114 bits (274), Expect = 1e-24
Identities = 55/105 (52%), Positives = 74/105 (70%)
Query: 543 LAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDR 602
LA+W + IV LVK +GLGFSILDYQDP+DP +VIV+RSLV GVAE++G + PGDR
Sbjct: 677 LALWSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDR 736
Query: 603 VMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPLPPQDSSKS 647
++SVN + N +L +AV+ LK P G V +GI +PL + +S
Sbjct: 737 LVSVNEYRLDNTSLAEAVEILKAVPPGLVHLGICKPLVEDNEEES 781
Score = 89.4 bits (212), Expect = 3e-17
Identities = 72/275 (26%), Positives = 127/275 (46%), Gaps = 29/275 (10%)
Query: 198 HVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLA 257
+V L ++ G G TV + EEL GIF+K ++E S A ++ +K D+I+EV G+ L
Sbjct: 1076 NVSLGISIVG-GQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQ 1134
Query: 258 DKSNPQSVEILRNTGISVHLVLERYLRGPKFEHLQLAIFNEERXXXXXXXXXXLSWFPVP 317
+ S+ ++VE ++N G V +++ P+ I N
Sbjct: 1135 NASHSEAVEAIKNAGNPVVFIVQSLSSTPR------VIPNVHNKANKITGN--------- 1179
Query: 318 SQLENSITEIEPEPESNTTIDSSVLEVGDLQEPTQEELDQRFDEILAVDKEDIVKKWKEE 377
+N T+ + E T +++ + ++ D+ +E D++ +++ +
Sbjct: 1180 ---QNQDTQEKKEKRQGTA--PPPMKLPPPYKALTDDSDENEEEDAFTDQK--IRQRYAD 1232
Query: 378 IGSDKEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDE 437
+ + I+ E K GLG+SL G D R ++ + P+GP G + GDE
Sbjct: 1233 LPGELHIIELE-KDKNGLGLSLAGNKD-----RSRMSIFVVGINPEGPAAADGRMRIGDE 1286
Query: 438 LLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARN 472
LLE+N L+G +H I+K P +V+LV RN
Sbjct: 1287 LLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRN 1321
Score = 72.1 bits (169), Expect = 6e-12
Identities = 64/287 (22%), Positives = 134/287 (46%), Gaps = 18/287 (6%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTGVVIKYVL---PGGVADKDRRLQSGDHVLQVGSVNL 65
++ ++EL D NGLG +L G + + +V+ P G A D R++ GD +L++ + L
Sbjct: 1236 ELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQIL 1295
Query: 66 RGFTSEQVAAVLRQAGPVVRLLVARPADPATALRA---PQPGTALVPTKILADPELLDRH 122
G + + +A+++ A V+L+ R D + P P ++ + + E +
Sbjct: 1296 YGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSE 1355
Query: 123 ---LIETGYGAVYDLSQC-YSDYNINGQNGETETSIVAAAVSVIGDNPQKIPDHPIV-CD 177
+E G + + + + Q T+ S + + + + D
Sbjct: 1356 EDGSLEVGIKQLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYG 1415
Query: 178 SVSPTITI---TVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGS 234
+++ T P+ +P E+I ++++K GLG+++ G + L+ I + + E
Sbjct: 1416 GFQAPLSVDPATCPI-VPGQEMI-IEISKGRSGLGLSIVGG--KDTPLNAIVIHEVYEEG 1471
Query: 235 SAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
+A + G++ D+I+EV+G+ L + S+ +++ LR T V LV+ R
Sbjct: 1472 AAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYR 1518
Score = 71.3 bits (167), Expect = 1e-11
Identities = 80/291 (27%), Positives = 126/291 (43%), Gaps = 37/291 (12%)
Query: 13 VELTN-DGNGLGFNLVG-------GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
VEL DG LG +VG G ++G+ +K ++PG A + +Q D ++ V VN
Sbjct: 366 VELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVN 425
Query: 65 LRGFTSEQVAAVLRQAGPVVRL-LVARPADPATA-LRAPQP-GTALVPTKILADPELLDR 121
++GF + V VLR AG VV L LV R +T+ L P GT + P K P L
Sbjct: 426 IQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLK---PPALFLT 482
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIG--DNPQKIPDHP------ 173
+ET + N++G++ E + I I + +K+PD P
Sbjct: 483 GAVET-------------ETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKS 529
Query: 174 IVCDSVSPTITITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSG-IFVKSIIE 232
+ + P + V +I +L K L I E + G ++ SI+
Sbjct: 530 RWENLLGPDYEVMVATLDTQI-ADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVS 588
Query: 233 GSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLERYL 283
G + G ++ D ++EV+G+ L KS ++V L+ LV R L
Sbjct: 589 GGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRL 639
Score = 59.3 bits (137), Expect = 4e-08
Identities = 65/245 (26%), Positives = 109/245 (44%), Gaps = 24/245 (9%)
Query: 395 LGISLEGTVDV----EGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLT 450
LGIS+ G V + G+EL+ +I+ VL D P G L GD++LEV+ L +
Sbjct: 1079 LGISIVGGQTVIKRLKNGEELKGI-FIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNAS 1137
Query: 451 HSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKA 510
HSE V +K + V + S+ S PR + N+ + +A K I+G+ N T K
Sbjct: 1138 HSEAVEAIKNAGNPVVFIV--QSLSSTPRVIPNVHN-----KANK-ITGNQNQDTQEKKE 1189
Query: 511 QSDTSINTSST-----ATLTNHSEQSKKSRSL---ECVSGLAMWQSKEDIVMLVKADQGL 562
+ + LT+ S+++++ + + A + I+ L K GL
Sbjct: 1190 KRQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGL 1249
Query: 563 GFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQA 622
G S+ + D + I V + P G A +G + GD ++ +N + + A
Sbjct: 1250 GLSLAGNK---DRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAI 1306
Query: 623 LKGAP 627
+K AP
Sbjct: 1307 IKTAP 1311
Score = 55.2 bits (127), Expect = 7e-07
Identities = 30/92 (32%), Positives = 52/92 (56%), Gaps = 8/92 (8%)
Query: 546 WQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMS 605
W E+ V L+ GLGF I V + +VVR++VPGG+A+++G + GD ++
Sbjct: 243 WGHVEE-VELINDGSGLGFGI------VGGKTSGVVVRTIVPGGLADRDGRLQTGDHILK 295
Query: 606 VNGVSIQNATLDQAVQALKGAPRGTVKVGIAR 637
+ G ++Q T +Q Q L+ +V++ +AR
Sbjct: 296 IGGTNVQGMTSEQVAQVLRNC-GNSVRMLVAR 326
Score = 52.4 bits (120), Expect = 5e-06
Identities = 31/89 (34%), Positives = 51/89 (57%), Gaps = 7/89 (7%)
Query: 9 QVEVVELTNDGNG-LGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDHVLQVGS 62
Q+E +++ G LGF++V RS + +K V PG VAD+D+RL+ D +L +
Sbjct: 131 QIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINH 190
Query: 63 VNL-RGFTSEQVAAVLRQAGPVVRLLVAR 90
L + + +Q A+L+Q +RL+VAR
Sbjct: 191 TPLDQNISHQQAIALLQQTTGSLRLIVAR 219
Score = 50.8 bits (116), Expect = 1e-05
Identities = 26/81 (32%), Positives = 50/81 (61%), Gaps = 5/81 (6%)
Query: 549 KEDIVMLVKADQGLGFSILDYQD-PVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVN 607
+E I+ + K GLG SI+ +D P++ IV+ + G A ++G + GD+++ VN
Sbjct: 1434 QEMIIEISKGRSGLGLSIVGGKDTPLN----AIVIHEVYEEGAAARDGRLWAGDQILEVN 1489
Query: 608 GVSIQNATLDQAVQALKGAPR 628
GV ++N++ ++A+ AL+ P+
Sbjct: 1490 GVDLRNSSHEEAITALRQTPQ 1510
Score = 50.4 bits (115), Expect = 2e-05
Identities = 31/91 (34%), Positives = 46/91 (50%), Gaps = 5/91 (5%)
Query: 382 KEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEV 441
+E+++ K GLG+S+ G D + I V +G G L AGD++LEV
Sbjct: 1434 QEMIIEISKGRSGLGLSIVGGKDTPLNAIV-----IHEVYEEGAAARDGRLWAGDQILEV 1488
Query: 442 NEYRLHGLTHSEVVNILKQLPDRVRLVCARN 472
N L +H E + L+Q P +VRLV R+
Sbjct: 1489 NGVDLRNSSHEEAITALRQTPQKVRLVVYRD 1519
Score = 49.6 bits (113), Expect = 3e-05
Identities = 26/96 (27%), Positives = 54/96 (56%), Gaps = 5/96 (5%)
Query: 186 TVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKIN 245
T+P + + V+L + GLG + G + SG+ V++I+ G A++ G+++
Sbjct: 236 TLPETVCWGHVEEVELINDGSGLGFGIVG-----GKTSGVVVRTIVPGGLADRDGRLQTG 290
Query: 246 DRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
D I+++ G ++ ++ Q ++LRN G SV +++ R
Sbjct: 291 DHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVAR 326
Score = 48.8 bits (111), Expect = 6e-05
Identities = 36/111 (32%), Positives = 51/111 (45%), Gaps = 7/111 (6%)
Query: 352 QEELDQRFDEILAVDKEDIVKKWKEEIGSDKEILVAEIKKLEGLGISLEGTVDVEGGQEL 411
+ E+D D D + + W E+ +V +K +GLG S+ D
Sbjct: 658 ETEVDHNMDVNTEEDDDGELALWSPEVK-----IVELVKDCKGLGFSILDYQDPL--DPT 710
Query: 412 RPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP 462
R IRS++ DG G L GD L+ VNEYRL + +E V ILK +P
Sbjct: 711 RSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYRLDNTSLAEAVEILKAVP 761
Score = 46.0 bits (104), Expect = 4e-04
Identities = 27/76 (35%), Positives = 41/76 (53%), Gaps = 2/76 (2%)
Query: 553 VMLVKAD-QGLGFSILDYQDPVDPN-GTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVS 610
V LV+ D Q LG I+ Y + I V+S++PG A NG I D++++V+GV+
Sbjct: 366 VELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVN 425
Query: 611 IQNATLDQAVQALKGA 626
IQ V+ L+ A
Sbjct: 426 IQGFANHDVVEVLRNA 441
Score = 44.4 bits (100), Expect = 0.001
Identities = 58/257 (22%), Positives = 99/257 (38%), Gaps = 24/257 (9%)
Query: 393 EGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHS 452
+ LGI + G V E Y++S++P G + D+++ V+ + G +
Sbjct: 374 QSLGIRIVGYVGTSHTGEASGI-YVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANH 432
Query: 453 EVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARK----IISGSLNNLTTL- 507
+VV +L+ V L R S P+ + E K ++G++ T +
Sbjct: 433 DVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLKPPALFLTGAVETETNVD 492
Query: 508 -----VKAQSDTSINTSSTA-----TLTNHSEQSKKSR-------SLECVSGLAMWQSKE 550
+K + DT N + A + + E KSR E + Q +
Sbjct: 493 GEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDYEVMVATLDTQIAD 552
Query: 551 DIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVS 610
D L K + L L VD + S+V GG + G + P D ++ VNG+
Sbjct: 553 D-AELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQ 611
Query: 611 IQNATLDQAVQALKGAP 627
+ + +AV LK P
Sbjct: 612 LYGKSRREAVSFLKEVP 628
Score = 43.6 bits (98), Expect = 0.002
Identities = 32/123 (26%), Positives = 59/123 (47%), Gaps = 6/123 (4%)
Query: 509 KAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILD 568
KA + T + +S AT T + ++ E + W + + + + LG SI+
Sbjct: 1027 KASAYTGMLSSRYATDTCELPEREEGEGEE-TPNFSHWGPPRIVEIFREPNVSLGISIVG 1085
Query: 569 YQDPVD--PNGTV---IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQAL 623
Q + NG I ++ ++ A K + GD+++ V+GV +QNA+ +AV+A+
Sbjct: 1086 GQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAI 1145
Query: 624 KGA 626
K A
Sbjct: 1146 KNA 1148
Score = 41.9 bits (94), Expect = 0.007
Identities = 25/89 (28%), Positives = 50/89 (56%), Gaps = 2/89 (2%)
Query: 195 EIIHVDLNK-NVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDG 253
+I ++D+ + + GLG +V + IFVK + GS A++ ++K ND+I+ ++
Sbjct: 131 QIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINH 190
Query: 254 ISLADK-SNPQSVEILRNTGISVHLVLER 281
L S+ Q++ +L+ T S+ L++ R
Sbjct: 191 TPLDQNISHQQAIALLQQTTGSLRLIVAR 219
Score = 41.5 bits (93), Expect = 0.009
Identities = 26/79 (32%), Positives = 46/79 (58%), Gaps = 3/79 (3%)
Query: 192 PEIEIIHVDLNKNVYGLGITVAGYVCEKEEL-SGIFVKSIIEGSSAEQSGKIKINDRIIE 250
PE++I V+L K+ GLG ++ Y + S I ++S++ AE+SG + DR++
Sbjct: 682 PEVKI--VELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVS 739
Query: 251 VDGISLADKSNPQSVEILR 269
V+ L + S ++VEIL+
Sbjct: 740 VNEYRLDNTSLAEAVEILK 758
Score = 40.3 bits (90), Expect = 0.021
Identities = 16/56 (28%), Positives = 32/56 (57%)
Query: 417 IRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARN 472
+R+++P G G L GD +L++ + G+T +V +L+ + VR++ AR+
Sbjct: 272 VRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARD 327
Score = 39.5 bits (88), Expect = 0.037
Identities = 25/93 (26%), Positives = 49/93 (52%), Gaps = 8/93 (8%)
Query: 7 WA-QVEVVELTNDGNGLGFNLVGGRS------TGVVIKYVLPGGVADKDRRLQSGDHVLQ 59
W+ +V++VEL D GLGF+++ + + +VI+ ++ GVA++ L GD ++
Sbjct: 680 WSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVS 739
Query: 60 VGSVNLRGFTSEQVAAVLRQAGP-VVRLLVARP 91
V L + + +L+ P +V L + +P
Sbjct: 740 VNEYRLDNTSLAEAVEILKAVPPGLVHLGICKP 772
>AJ001306-1|CAA04666.1| 1524|Homo sapiens PDZ domain protein
protein.
Length = 1524
Score = 126 bits (303), Expect = 3e-28
Identities = 99/316 (31%), Positives = 152/316 (48%), Gaps = 25/316 (7%)
Query: 178 SVSPTITITVPVELPEI------------EIIHVDL-NKNVYGLGITVAGYVCEKE--EL 222
SV+P +PV LP + E +V+L K+ LGI + GYV E
Sbjct: 333 SVTPPAPAALPVALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEA 392
Query: 223 SGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLERY 282
SGI+VKSII GS+A +G I++ND+I+ VDG+++ +N VE+LRN G VHL L R
Sbjct: 393 SGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRR 452
Query: 283 LRGPKFEHLQLAIFNEERXXXXXXXXXXLSW-FPVPSQLENSITEIEPEPESNTTIDSSV 341
L+ L+ + ++ EI+ ++ +
Sbjct: 453 KTSSSTSPLEPPSDRGTVVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQA 512
Query: 342 LE-VGDLQEPTQEELDQRFDEILAVDKEDIVKKWKEEIGSDKEI-LVAEIKKLEGLGISL 399
LE + + + + EL R++ +L D E +V +I D E+ +++ + L + +
Sbjct: 513 LEKLEKVPDSPENELKSRWENLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGV 572
Query: 400 EGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILK 459
E VD G HHYI S++ GPV G+L DELLEVN +L+G + E V+ LK
Sbjct: 573 E--VDSFDG-----HHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLK 625
Query: 460 QLPDRVRLVCARNSID 475
++P LVC R D
Sbjct: 626 EVPPPFTLVCCRRLFD 641
Score = 125 bits (302), Expect = 4e-28
Identities = 57/106 (53%), Positives = 78/106 (73%), Gaps = 2/106 (1%)
Query: 7 WAQVEVVELTNDGNGLGFNLVGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLR 66
W VE VEL NDG+GLGF +VGG+++GVV++ ++PGG+AD+D RLQ+GDH+L++G N++
Sbjct: 243 WGHVEEVELINDGSGLGFGIVGGKTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQ 302
Query: 67 GFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVPTKI 112
G TSEQVA VLR G VR+LVAR DPA + P A +P +
Sbjct: 303 GMTSEQVAQVLRNCGNSVRMLVAR--DPAGDISVTPPAPAALPVAL 346
Score = 114 bits (274), Expect = 1e-24
Identities = 55/105 (52%), Positives = 74/105 (70%)
Query: 543 LAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDR 602
LA+W + IV LVK +GLGFSILDYQDP+DP +VIV+RSLV GVAE++G + PGDR
Sbjct: 677 LALWSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDR 736
Query: 603 VMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPLPPQDSSKS 647
++SVN + N +L +AV+ LK P G V +GI +PL + +S
Sbjct: 737 LVSVNEYRLDNTSLAEAVEILKAVPPGLVHLGICKPLVEDNEEES 781
Score = 91.5 bits (217), Expect = 9e-18
Identities = 102/439 (23%), Positives = 185/439 (42%), Gaps = 40/439 (9%)
Query: 198 HVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLA 257
+V L ++ G G TV + EEL GIF+K ++E S A ++ +K D+I+EV G+ L
Sbjct: 1076 NVSLGISIVG-GQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQ 1134
Query: 258 DKSNPQSVEILRNTGISVHLVLERYLRGPKFEHLQLAIFNEERXXXXXXXXXXLSWFPVP 317
+ S+ ++VE ++N G V +++ P+ I N
Sbjct: 1135 NASHSEAVEAIKNAGNPVVFIVQSLSSTPR------VIPNVHNKANKITGN--------- 1179
Query: 318 SQLENSITEIEPEPESNTTIDSSVLEVGDLQEPTQEELDQRFDEILAVDKEDIVKKWKEE 377
+N T+ + E T +++ + ++ D+ +E D++ +++ +
Sbjct: 1180 ---QNQDTQEKKEKRQGTA--PPPMKLPPPYKALTDDSDENEEEDAFTDQK--IRQRYAD 1232
Query: 378 IGSDKEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDE 437
+ + I+ E K GLG+SL G D R ++ + P+GP G ++ GDE
Sbjct: 1233 LPGELHIIELE-KDKNGLGLSLAGNKD-----RSRMSIFVVGINPEGPAAADGRMHIGDE 1286
Query: 438 LLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARN-------SIDSGPRPVVNLASDREG 490
LLE+N L+G +H I+K P +V+LV RN ++ P P + +S +
Sbjct: 1287 LLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQ 1346
Query: 491 FEARKIISGSLNNLTTLVKAQSDTSINTSSTATLTNHSEQSKKS-RSLECVSGLAMWQSK 549
I S +L +K ++ + + + +K S S E A
Sbjct: 1347 SGTEPISSEEDGSLEVGIKQLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHS 1406
Query: 550 EDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGV 609
D S+ P+ P +I+ S G+ I G VNGV
Sbjct: 1407 TDADFTGYGGFQAPLSVDPATCPIVPGQEMIIEISKRRSGLGL---SIVGGKDTPLVNGV 1463
Query: 610 SIQNATLDQAVQALKGAPR 628
++N++ ++A+ AL+ P+
Sbjct: 1464 DLRNSSHEEAITALRQTPQ 1482
Score = 71.3 bits (167), Expect = 1e-11
Identities = 80/291 (27%), Positives = 126/291 (43%), Gaps = 37/291 (12%)
Query: 13 VELTN-DGNGLGFNLVG-------GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
VEL DG LG +VG G ++G+ +K ++PG A + +Q D ++ V VN
Sbjct: 366 VELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVN 425
Query: 65 LRGFTSEQVAAVLRQAGPVVRL-LVARPADPATA-LRAPQP-GTALVPTKILADPELLDR 121
++GF + V VLR AG VV L LV R +T+ L P GT + P K P L
Sbjct: 426 IQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLK---PPALFLT 482
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIG--DNPQKIPDHP------ 173
+ET + N++G++ E + I I + +K+PD P
Sbjct: 483 GAVET-------------ETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKS 529
Query: 174 IVCDSVSPTITITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSG-IFVKSIIE 232
+ + P + V +I +L K L I E + G ++ SI+
Sbjct: 530 RWENLLGPDYEVMVATLDTQI-ADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVS 588
Query: 233 GSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLERYL 283
G + G ++ D ++EV+G+ L KS ++V L+ LV R L
Sbjct: 589 GGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRL 639
Score = 55.2 bits (127), Expect = 7e-07
Identities = 30/92 (32%), Positives = 52/92 (56%), Gaps = 8/92 (8%)
Query: 546 WQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMS 605
W E+ V L+ GLGF I V + +VVR++VPGG+A+++G + GD ++
Sbjct: 243 WGHVEE-VELINDGSGLGFGI------VGGKTSGVVVRTIVPGGLADRDGRLQTGDHILK 295
Query: 606 VNGVSIQNATLDQAVQALKGAPRGTVKVGIAR 637
+ G ++Q T +Q Q L+ +V++ +AR
Sbjct: 296 IGGTNVQGMTSEQVAQVLRNC-GNSVRMLVAR 326
Score = 52.4 bits (120), Expect = 5e-06
Identities = 31/89 (34%), Positives = 51/89 (57%), Gaps = 7/89 (7%)
Query: 9 QVEVVELTNDGNG-LGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDHVLQVGS 62
Q+E +++ G LGF++V RS + +K V PG VAD+D+RL+ D +L +
Sbjct: 131 QIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINH 190
Query: 63 VNL-RGFTSEQVAAVLRQAGPVVRLLVAR 90
L + + +Q A+L+Q +RL+VAR
Sbjct: 191 TPLDQNISHQQAIALLQQTTGSLRLIVAR 219
Score = 50.8 bits (116), Expect = 1e-05
Identities = 30/108 (27%), Positives = 55/108 (50%), Gaps = 4/108 (3%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTGVVIKYVL---PGGVADKDRRLQSGDHVLQVGSVNL 65
++ ++EL D NGLG +L G + + +V+ P G A D R+ GD +L++ + L
Sbjct: 1236 ELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMHIGDELLEINNQIL 1295
Query: 66 RGFTSEQVAAVLRQAGPVVRLLVARPADPATALR-APQPGTALVPTKI 112
G + + +A+++ A V+L+ R D + P P + P+ I
Sbjct: 1296 YGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSI 1343
Score = 49.6 bits (113), Expect = 3e-05
Identities = 26/96 (27%), Positives = 54/96 (56%), Gaps = 5/96 (5%)
Query: 186 TVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKIN 245
T+P + + V+L + GLG + G + SG+ V++I+ G A++ G+++
Sbjct: 236 TLPETVCWGHVEEVELINDGSGLGFGIVG-----GKTSGVVVRTIVPGGLADRDGRLQTG 290
Query: 246 DRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
D I+++ G ++ ++ Q ++LRN G SV +++ R
Sbjct: 291 DHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVAR 326
Score = 48.8 bits (111), Expect = 6e-05
Identities = 36/111 (32%), Positives = 51/111 (45%), Gaps = 7/111 (6%)
Query: 352 QEELDQRFDEILAVDKEDIVKKWKEEIGSDKEILVAEIKKLEGLGISLEGTVDVEGGQEL 411
+ E+D D D + + W E+ +V +K +GLG S+ D
Sbjct: 658 ETEVDHNMDVNTEEDDDGELALWSPEVK-----IVELVKDCKGLGFSILDYQDPL--DPT 710
Query: 412 RPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP 462
R IRS++ DG G L GD L+ VNEYRL + +E V ILK +P
Sbjct: 711 RSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYRLDNTSLAEAVEILKAVP 761
Score = 46.0 bits (104), Expect = 4e-04
Identities = 27/76 (35%), Positives = 41/76 (53%), Gaps = 2/76 (2%)
Query: 553 VMLVKAD-QGLGFSILDYQDPVDPN-GTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVS 610
V LV+ D Q LG I+ Y + I V+S++PG A NG I D++++V+GV+
Sbjct: 366 VELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVN 425
Query: 611 IQNATLDQAVQALKGA 626
IQ V+ L+ A
Sbjct: 426 IQGFANHDVVEVLRNA 441
Score = 45.2 bits (102), Expect = 7e-04
Identities = 72/285 (25%), Positives = 114/285 (40%), Gaps = 36/285 (12%)
Query: 195 EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGI 254
E+ ++L K+ GLG+++AG ++ +S IFV I A G++ I D ++E++
Sbjct: 1236 ELHIIELEKDKNGLGLSLAGNK-DRSRMS-IFVVGINPEGPAAADGRMHIGDELLEINNQ 1293
Query: 255 SLADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHLQLAIFNEERXXXXXXXXXXLSWF 314
L +S+ + I++ V LV R NE+ ++ F
Sbjct: 1294 ILYGRSHQNASAIIKTAPSKVKLVFIR---------------NED-----AVNQMAVTPF 1333
Query: 315 PVPSQLENSITEIEPEPESNTTIDSSVLEVGDLQEPTQEELDQRFDEILAVDKEDIVKKW 374
PVPS +SI E + E ++ + LEVG Q P E ++ V
Sbjct: 1334 PVPSSSPSSI-EDQSGTEPISSEEDGSLEVGIKQLPESESFKLAVSQMKQQKYPTKVSFS 1392
Query: 375 KEEI----GSDKEILVAEIKKLEGLGISLE---GTVDVEGGQELRPHHYIRSVLPDGPVG 427
+EI S A+ G L T + GQE+ I +G
Sbjct: 1393 SQEIPLAPASSYHSTDADFTGYGGFQAPLSVDPATCPIVPGQEM----IIEISKRRSGLG 1448
Query: 428 LQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARN 472
L V G + VN L +H E + L+Q P +VRLV R+
Sbjct: 1449 LSIV--GGKDTPLVNGVDLRNSSHEEAITALRQTPQKVRLVVYRD 1491
Score = 44.4 bits (100), Expect = 0.001
Identities = 58/257 (22%), Positives = 99/257 (38%), Gaps = 24/257 (9%)
Query: 393 EGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHS 452
+ LGI + G V E Y++S++P G + D+++ V+ + G +
Sbjct: 374 QSLGIRIVGYVGTSHTGEASGI-YVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANH 432
Query: 453 EVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARK----IISGSLNNLTTL- 507
+VV +L+ V L R S P+ + E K ++G++ T +
Sbjct: 433 DVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLKPPALFLTGAVETETNVD 492
Query: 508 -----VKAQSDTSINTSSTA-----TLTNHSEQSKKSR-------SLECVSGLAMWQSKE 550
+K + DT N + A + + E KSR E + Q +
Sbjct: 493 GEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDYEVMVATLDTQIAD 552
Query: 551 DIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVS 610
D L K + L L VD + S+V GG + G + P D ++ VNG+
Sbjct: 553 D-AELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQ 611
Query: 611 IQNATLDQAVQALKGAP 627
+ + +AV LK P
Sbjct: 612 LYGKSRREAVSFLKEVP 628
Score = 43.6 bits (98), Expect = 0.002
Identities = 32/123 (26%), Positives = 59/123 (47%), Gaps = 6/123 (4%)
Query: 509 KAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILD 568
KA + T + +S AT T + ++ E + W + + + + LG SI+
Sbjct: 1027 KASAYTGMLSSRYATDTCELPEREEGEGEE-TPNFSHWGPPRIVEIFREPNVSLGISIVG 1085
Query: 569 YQDPVD--PNGTV---IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQAL 623
Q + NG I ++ ++ A K + GD+++ V+GV +QNA+ +AV+A+
Sbjct: 1086 GQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAI 1145
Query: 624 KGA 626
K A
Sbjct: 1146 KNA 1148
Score = 41.9 bits (94), Expect = 0.007
Identities = 25/89 (28%), Positives = 50/89 (56%), Gaps = 2/89 (2%)
Query: 195 EIIHVDLNK-NVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDG 253
+I ++D+ + + GLG +V + IFVK + GS A++ ++K ND+I+ ++
Sbjct: 131 QIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINH 190
Query: 254 ISLADK-SNPQSVEILRNTGISVHLVLER 281
L S+ Q++ +L+ T S+ L++ R
Sbjct: 191 TPLDQNISHQQAIALLQQTTGSLRLIVAR 219
Score = 41.5 bits (93), Expect = 0.009
Identities = 26/79 (32%), Positives = 46/79 (58%), Gaps = 3/79 (3%)
Query: 192 PEIEIIHVDLNKNVYGLGITVAGYVCEKEEL-SGIFVKSIIEGSSAEQSGKIKINDRIIE 250
PE++I V+L K+ GLG ++ Y + S I ++S++ AE+SG + DR++
Sbjct: 682 PEVKI--VELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVS 739
Query: 251 VDGISLADKSNPQSVEILR 269
V+ L + S ++VEIL+
Sbjct: 740 VNEYRLDNTSLAEAVEILK 758
Score = 40.3 bits (90), Expect = 0.021
Identities = 16/56 (28%), Positives = 32/56 (57%)
Query: 417 IRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARN 472
+R+++P G G L GD +L++ + G+T +V +L+ + VR++ AR+
Sbjct: 272 VRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARD 327
Score = 39.5 bits (88), Expect = 0.037
Identities = 25/93 (26%), Positives = 49/93 (52%), Gaps = 8/93 (8%)
Query: 7 WA-QVEVVELTNDGNGLGFNLVGGRS------TGVVIKYVLPGGVADKDRRLQSGDHVLQ 59
W+ +V++VEL D GLGF+++ + + +VI+ ++ GVA++ L GD ++
Sbjct: 680 WSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVS 739
Query: 60 VGSVNLRGFTSEQVAAVLRQAGP-VVRLLVARP 91
V L + + +L+ P +V L + +P
Sbjct: 740 VNEYRLDNTSLAEAVEILKAVPPGLVHLGICKP 772
>AF397170-1|AAM28433.1| 1801|Homo sapiens Pals1-associated tight
junction protein protein.
Length = 1801
Score = 126 bits (303), Expect = 3e-28
Identities = 99/316 (31%), Positives = 152/316 (48%), Gaps = 25/316 (7%)
Query: 178 SVSPTITITVPVELPEI------------EIIHVDL-NKNVYGLGITVAGYVCEKE--EL 222
SV+P +PV LP + E +V+L K+ LGI + GYV E
Sbjct: 333 SVTPPAPAALPVALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEA 392
Query: 223 SGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLERY 282
SGI+VKSII GS+A +G I++ND+I+ VDG+++ +N VE+LRN G VHL L R
Sbjct: 393 SGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRR 452
Query: 283 LRGPKFEHLQLAIFNEERXXXXXXXXXXLSW-FPVPSQLENSITEIEPEPESNTTIDSSV 341
L+ L+ + ++ EI+ ++ +
Sbjct: 453 KTSSSTSPLEPPSDRGTVVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQA 512
Query: 342 LE-VGDLQEPTQEELDQRFDEILAVDKEDIVKKWKEEIGSDKEI-LVAEIKKLEGLGISL 399
LE + + + + EL R++ +L D E +V +I D E+ +++ + L + +
Sbjct: 513 LEKLEKVPDSPENELKSRWENLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGV 572
Query: 400 EGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILK 459
E VD G HHYI S++ GPV G+L DELLEVN +L+G + E V+ LK
Sbjct: 573 E--VDSFDG-----HHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLK 625
Query: 460 QLPDRVRLVCARNSID 475
++P LVC R D
Sbjct: 626 EVPPPFTLVCCRRLFD 641
Score = 125 bits (302), Expect = 4e-28
Identities = 57/106 (53%), Positives = 78/106 (73%), Gaps = 2/106 (1%)
Query: 7 WAQVEVVELTNDGNGLGFNLVGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLR 66
W VE VEL NDG+GLGF +VGG+++GVV++ ++PGG+AD+D RLQ+GDH+L++G N++
Sbjct: 243 WGHVEEVELINDGSGLGFGIVGGKTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQ 302
Query: 67 GFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVPTKI 112
G TSEQVA VLR G VR+LVAR DPA + P A +P +
Sbjct: 303 GMTSEQVAQVLRNCGNSVRMLVAR--DPAGDISVTPPAPAALPVAL 346
Score = 114 bits (274), Expect = 1e-24
Identities = 55/105 (52%), Positives = 74/105 (70%)
Query: 543 LAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDR 602
LA+W + IV LVK +GLGFSILDYQDP+DP +VIV+RSLV GVAE++G + PGDR
Sbjct: 677 LALWSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDR 736
Query: 603 VMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPLPPQDSSKS 647
++SVN + N +L +AV+ LK P G V +GI +PL + +S
Sbjct: 737 LVSVNEYCLDNTSLAEAVEILKAVPPGLVHLGICKPLVEDNEEES 781
Score = 89.8 bits (213), Expect = 3e-17
Identities = 72/275 (26%), Positives = 127/275 (46%), Gaps = 29/275 (10%)
Query: 198 HVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLA 257
+V L ++ G G TV + EEL GIF+K ++E S A ++ +K D+I+EV G+ L
Sbjct: 1076 NVSLGISIVG-GQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQ 1134
Query: 258 DKSNPQSVEILRNTGISVHLVLERYLRGPKFEHLQLAIFNEERXXXXXXXXXXLSWFPVP 317
+ S+ ++VE ++N G V +++ P+ I N
Sbjct: 1135 NASHSEAVEAIKNAGNPVVFIVQSLSSTPR------VIPNVHNKANKITSN--------- 1179
Query: 318 SQLENSITEIEPEPESNTTIDSSVLEVGDLQEPTQEELDQRFDEILAVDKEDIVKKWKEE 377
+N T+ + E T +++ + ++ D+ +E D++ +++ +
Sbjct: 1180 ---QNQDTQEKKEKRQGTA--PPPMKLPPPYKALTDDSDENEEEDAFTDQK--IRQRYAD 1232
Query: 378 IGSDKEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDE 437
+ + I+ E K GLG+SL G D R ++ + P+GP G + GDE
Sbjct: 1233 LPGELHIIELE-KDKNGLGLSLAGNKD-----RSRMSIFVVGINPEGPAAADGRMRIGDE 1286
Query: 438 LLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARN 472
LLE+N L+G +H I+K P +V+LV RN
Sbjct: 1287 LLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRN 1321
Score = 72.5 bits (170), Expect = 4e-12
Identities = 64/287 (22%), Positives = 134/287 (46%), Gaps = 18/287 (6%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTGVVIKYVL---PGGVADKDRRLQSGDHVLQVGSVNL 65
++ ++EL D NGLG +L G + + +V+ P G A D R++ GD +L++ + L
Sbjct: 1236 ELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQIL 1295
Query: 66 RGFTSEQVAAVLRQAGPVVRLLVARPADPATALRA---PQPGTALVPTKILADPELLDRH 122
G + + +A+++ A V+L+ R D + P P ++ + + E +
Sbjct: 1296 YGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSE 1355
Query: 123 ---LIETGYGAVYDLSQC-YSDYNINGQNGETETSIVAAAVSVIGDNPQKIPDHPIV-CD 177
+E G + + + + Q T+ S + + + + D
Sbjct: 1356 EDGSVEVGIKQLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYG 1415
Query: 178 SVSPTITI---TVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGS 234
+++ T P+ +P E+I ++++K GLG+++ G + L+ I + + E
Sbjct: 1416 GFQAPLSVDPATCPI-VPGQEMI-IEISKGRSGLGLSIVGG--KDTPLNAIVIHEVYEEG 1471
Query: 235 SAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
+A + G++ D+I+EV+G+ L + S+ +++ LR T V LV+ R
Sbjct: 1472 AAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYR 1518
Score = 71.3 bits (167), Expect = 1e-11
Identities = 80/291 (27%), Positives = 126/291 (43%), Gaps = 37/291 (12%)
Query: 13 VELTN-DGNGLGFNLVG-------GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
VEL DG LG +VG G ++G+ +K ++PG A + +Q D ++ V VN
Sbjct: 366 VELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVN 425
Query: 65 LRGFTSEQVAAVLRQAGPVVRL-LVARPADPATA-LRAPQP-GTALVPTKILADPELLDR 121
++GF + V VLR AG VV L LV R +T+ L P GT + P K P L
Sbjct: 426 IQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLK---PPALFLT 482
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIG--DNPQKIPDHP------ 173
+ET + N++G++ E + I I + +K+PD P
Sbjct: 483 GAVET-------------ETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKS 529
Query: 174 IVCDSVSPTITITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSG-IFVKSIIE 232
+ + P + V +I +L K L I E + G ++ SI+
Sbjct: 530 RWENLLGPDYEVMVATLDTQI-ADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVS 588
Query: 233 GSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLERYL 283
G + G ++ D ++EV+G+ L KS ++V L+ LV R L
Sbjct: 589 GGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRL 639
Score = 60.1 bits (139), Expect = 2e-08
Identities = 63/244 (25%), Positives = 107/244 (43%), Gaps = 22/244 (9%)
Query: 395 LGISLEGTVDV----EGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLT 450
LGIS+ G V + G+EL+ +I+ VL D P G L GD++LEV+ L +
Sbjct: 1079 LGISIVGGQTVIKRLKNGEELKGI-FIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNAS 1137
Query: 451 HSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKA 510
HSE V +K + V + S+ S PR + N+ + +A KI S + +
Sbjct: 1138 HSEAVEAIKNAGNPVVFIV--QSLSSTPRVIPNVHN-----KANKITSNQNQDTQEKKEK 1190
Query: 511 QSDTSINTSST----ATLTNHSEQSKKSRSL---ECVSGLAMWQSKEDIVMLVKADQGLG 563
+ T+ LT+ S+++++ + + A + I+ L K GLG
Sbjct: 1191 RQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGLG 1250
Query: 564 FSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQAL 623
S+ + D + I V + P G A +G + GD ++ +N + + A +
Sbjct: 1251 LSLAGNK---DRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAII 1307
Query: 624 KGAP 627
K AP
Sbjct: 1308 KTAP 1311
Score = 57.6 bits (133), Expect = 1e-07
Identities = 30/73 (41%), Positives = 45/73 (61%), Gaps = 1/73 (1%)
Query: 19 GNGLGFNLVGGRS-TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAVL 77
G GLG ++VG R+ +GV I ++ GG AD D RL GD +L V ++R + E VA +L
Sbjct: 1541 GRGLGLSIVGKRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATIL 1600
Query: 78 RQAGPVVRLLVAR 90
+ A +V+L + R
Sbjct: 1601 KCAQGLVQLEIGR 1613
Score = 55.2 bits (127), Expect = 7e-07
Identities = 30/92 (32%), Positives = 52/92 (56%), Gaps = 8/92 (8%)
Query: 546 WQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMS 605
W E+ V L+ GLGF I V + +VVR++VPGG+A+++G + GD ++
Sbjct: 243 WGHVEE-VELINDGSGLGFGI------VGGKTSGVVVRTIVPGGLADRDGRLQTGDHILK 295
Query: 606 VNGVSIQNATLDQAVQALKGAPRGTVKVGIAR 637
+ G ++Q T +Q Q L+ +V++ +AR
Sbjct: 296 IGGTNVQGMTSEQVAQVLRNC-GNSVRMLVAR 326
Score = 52.4 bits (120), Expect = 5e-06
Identities = 31/89 (34%), Positives = 51/89 (57%), Gaps = 7/89 (7%)
Query: 9 QVEVVELTNDGNG-LGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDHVLQVGS 62
Q+E +++ G LGF++V RS + +K V PG VAD+D+RL+ D +L +
Sbjct: 131 QIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINH 190
Query: 63 VNL-RGFTSEQVAAVLRQAGPVVRLLVAR 90
L + + +Q A+L+Q +RL+VAR
Sbjct: 191 TPLDQNISHQQAIALLQQTTGSLRLIVAR 219
Score = 51.6 bits (118), Expect = 9e-06
Identities = 29/81 (35%), Positives = 49/81 (60%), Gaps = 6/81 (7%)
Query: 557 KADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATL 616
KA +GLG SI+ + NG+ + + +V GG A+ +G + GD+++SVNG ++NA+
Sbjct: 1539 KAGRGLGLSIVGKR-----NGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQ 1593
Query: 617 DQAVQALKGAPRGTVKVGIAR 637
+ LK A +G V++ I R
Sbjct: 1594 ETVATILKCA-QGLVQLEIGR 1613
Score = 50.8 bits (116), Expect = 1e-05
Identities = 26/81 (32%), Positives = 50/81 (61%), Gaps = 5/81 (6%)
Query: 549 KEDIVMLVKADQGLGFSILDYQD-PVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVN 607
+E I+ + K GLG SI+ +D P++ IV+ + G A ++G + GD+++ VN
Sbjct: 1434 QEMIIEISKGRSGLGLSIVGGKDTPLN----AIVIHEVYEEGAAARDGRLWAGDQILEVN 1489
Query: 608 GVSIQNATLDQAVQALKGAPR 628
GV ++N++ ++A+ AL+ P+
Sbjct: 1490 GVDLRNSSHEEAITALRQTPQ 1510
Score = 50.4 bits (115), Expect = 2e-05
Identities = 31/91 (34%), Positives = 46/91 (50%), Gaps = 5/91 (5%)
Query: 382 KEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEV 441
+E+++ K GLG+S+ G D + I V +G G L AGD++LEV
Sbjct: 1434 QEMIIEISKGRSGLGLSIVGGKDTPLNAIV-----IHEVYEEGAAARDGRLWAGDQILEV 1488
Query: 442 NEYRLHGLTHSEVVNILKQLPDRVRLVCARN 472
N L +H E + L+Q P +VRLV R+
Sbjct: 1489 NGVDLRNSSHEEAITALRQTPQKVRLVVYRD 1519
Score = 50.0 bits (114), Expect = 3e-05
Identities = 43/173 (24%), Positives = 75/173 (43%), Gaps = 13/173 (7%)
Query: 194 IEIIHVDLNKNV-YGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVD 252
+EI VDL K GLG+++ G K SG+F+ I++G +A+ G++ D+I+ V+
Sbjct: 1529 LEIFPVDLQKKAGRGLGLSIVG----KRNGSGVFISDIVKGGAADLDGRLIQGDQILSVN 1584
Query: 253 GISLADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHLQLAIFNEERXXXXXXXXXXLS 312
G + + S IL+ V L + R LR + + N + S
Sbjct: 1585 GEDMRNASQETVATILKCAQGLVQLEIGR-LRAGSWTSARTTSQNSQGSQQSAHSSCHPS 1643
Query: 313 WFPVPSQLENSITEIEPEPESNTTIDSSVLEVGDLQEPTQEELDQRFDEILAV 365
+ PV + L+N + + D S G EP E+++ + L +
Sbjct: 1644 FAPVITGLQNLV-------GTKRVSDPSQKNSGTDMEPRTVEINRELSDALGI 1689
Score = 49.6 bits (113), Expect = 3e-05
Identities = 26/96 (27%), Positives = 54/96 (56%), Gaps = 5/96 (5%)
Query: 186 TVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKIN 245
T+P + + V+L + GLG + G + SG+ V++I+ G A++ G+++
Sbjct: 236 TLPETVCWGHVEEVELINDGSGLGFGIVG-----GKTSGVVVRTIVPGGLADRDGRLQTG 290
Query: 246 DRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
D I+++ G ++ ++ Q ++LRN G SV +++ R
Sbjct: 291 DHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVAR 326
Score = 46.0 bits (104), Expect = 4e-04
Identities = 27/76 (35%), Positives = 41/76 (53%), Gaps = 2/76 (2%)
Query: 553 VMLVKAD-QGLGFSILDYQDPVDPN-GTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVS 610
V LV+ D Q LG I+ Y + I V+S++PG A NG I D++++V+GV+
Sbjct: 366 VELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVN 425
Query: 611 IQNATLDQAVQALKGA 626
IQ V+ L+ A
Sbjct: 426 IQGFANHDVVEVLRNA 441
Score = 45.6 bits (103), Expect = 6e-04
Identities = 35/111 (31%), Positives = 50/111 (45%), Gaps = 7/111 (6%)
Query: 352 QEELDQRFDEILAVDKEDIVKKWKEEIGSDKEILVAEIKKLEGLGISLEGTVDVEGGQEL 411
+ E+D D D + + W E+ +V +K +GLG S+ D
Sbjct: 658 ETEVDHNMDVNTEEDDDGELALWSPEVK-----IVELVKDCKGLGFSILDYQDPL--DPT 710
Query: 412 RPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP 462
R IRS++ DG G L GD L+ VNEY L + +E V ILK +P
Sbjct: 711 RSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAVP 761
Score = 44.4 bits (100), Expect = 0.001
Identities = 58/257 (22%), Positives = 99/257 (38%), Gaps = 24/257 (9%)
Query: 393 EGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHS 452
+ LGI + G V E Y++S++P G + D+++ V+ + G +
Sbjct: 374 QSLGIRIVGYVGTSHTGEASGI-YVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANH 432
Query: 453 EVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARK----IISGSLNNLTTL- 507
+VV +L+ V L R S P+ + E K ++G++ T +
Sbjct: 433 DVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLKPPALFLTGAVETETNVD 492
Query: 508 -----VKAQSDTSINTSSTA-----TLTNHSEQSKKSR-------SLECVSGLAMWQSKE 550
+K + DT N + A + + E KSR E + Q +
Sbjct: 493 GEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDYEVMVATLDTQIAD 552
Query: 551 DIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVS 610
D L K + L L VD + S+V GG + G + P D ++ VNG+
Sbjct: 553 D-AELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQ 611
Query: 611 IQNATLDQAVQALKGAP 627
+ + +AV LK P
Sbjct: 612 LYGKSRREAVSFLKEVP 628
Score = 44.4 bits (100), Expect = 0.001
Identities = 39/157 (24%), Positives = 71/157 (45%), Gaps = 11/157 (7%)
Query: 509 KAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILD 568
KA + T + +S AT T + ++ E + W + + + + LG SI+
Sbjct: 1027 KASAYTGMLSSRYATDTCELPEREEGEGEE-TPNFSHWGPPRIVEIFREPNVSLGISIVG 1085
Query: 569 YQDPVD--PNGTV---IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQAL 623
Q + NG I ++ ++ A K + GD+++ V+GV +QNA+ +AV+A+
Sbjct: 1086 GQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAI 1145
Query: 624 KGAPRGTVKV-----GIARPLPPQDSSKSKGTINVNK 655
K A V + R +P + +K T N N+
Sbjct: 1146 KNAGNPVVFIVQSLSSTPRVIPNVHNKANKITSNQNQ 1182
Score = 41.9 bits (94), Expect = 0.007
Identities = 25/89 (28%), Positives = 50/89 (56%), Gaps = 2/89 (2%)
Query: 195 EIIHVDLNK-NVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDG 253
+I ++D+ + + GLG +V + IFVK + GS A++ ++K ND+I+ ++
Sbjct: 131 QIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINH 190
Query: 254 ISLADK-SNPQSVEILRNTGISVHLVLER 281
L S+ Q++ +L+ T S+ L++ R
Sbjct: 191 TPLDQNISHQQAIALLQQTTGSLRLIVAR 219
Score = 41.5 bits (93), Expect = 0.009
Identities = 26/79 (32%), Positives = 46/79 (58%), Gaps = 3/79 (3%)
Query: 192 PEIEIIHVDLNKNVYGLGITVAGYVCEKEEL-SGIFVKSIIEGSSAEQSGKIKINDRIIE 250
PE++I V+L K+ GLG ++ Y + S I ++S++ AE+SG + DR++
Sbjct: 682 PEVKI--VELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVS 739
Query: 251 VDGISLADKSNPQSVEILR 269
V+ L + S ++VEIL+
Sbjct: 740 VNEYCLDNTSLAEAVEILK 758
Score = 40.3 bits (90), Expect = 0.021
Identities = 16/56 (28%), Positives = 32/56 (57%)
Query: 417 IRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARN 472
+R+++P G G L GD +L++ + G+T +V +L+ + VR++ AR+
Sbjct: 272 VRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARD 327
Score = 39.1 bits (87), Expect = 0.049
Identities = 32/111 (28%), Positives = 52/111 (46%), Gaps = 6/111 (5%)
Query: 379 GSDKEILVAEIKK--LEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGD 436
G+D E EI + + LGIS+ G G +I + G L GD
Sbjct: 1669 GTDMEPRTVEINRELSDALGISIAGG---RGSPIGDIPVFIAMIQASGVAARTQKLKVGD 1725
Query: 437 ELLEVNEYRLHGLTHSEVVNILKQLPDRVRL-VCARNSIDSGPRPVVNLAS 486
++ +N L GL+H++VVN+LK R+ L V A +I + + N+++
Sbjct: 1726 RIVSINGQPLDGLSHADVVNLLKNAYGRIILQVVADTNISAIAAQLENMST 1776
Score = 38.3 bits (85), Expect = 0.085
Identities = 25/93 (26%), Positives = 49/93 (52%), Gaps = 8/93 (8%)
Query: 7 WA-QVEVVELTNDGNGLGFNLVGGRS------TGVVIKYVLPGGVADKDRRLQSGDHVLQ 59
W+ +V++VEL D GLGF+++ + + +VI+ ++ GVA++ L GD ++
Sbjct: 680 WSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVS 739
Query: 60 VGSVNLRGFTSEQVAAVLRQAGP-VVRLLVARP 91
V L + + +L+ P +V L + +P
Sbjct: 740 VNEYCLDNTSLAEAVEILKAVPPGLVHLGICKP 772
Score = 37.1 bits (82), Expect = 0.20
Identities = 53/245 (21%), Positives = 94/245 (38%), Gaps = 25/245 (10%)
Query: 383 EILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVN 442
EI +++K G G+ L V G + +I ++ G L G L GD++L VN
Sbjct: 1530 EIFPVDLQKKAGRGLGLS-IVGKRNGSGV----FISDIVKGGAADLDGRLIQGDQILSVN 1584
Query: 443 EYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLN 502
+ + V ILK V+L R + +G S + S
Sbjct: 1585 GEDMRNASQETVATILKCAQGLVQLEIGR--LRAGSWTSARTTSQNSQGSQQSAHSSCHP 1642
Query: 503 NLTTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGL 562
+ ++ N T +++ S+++ SG M + + + L
Sbjct: 1643 SFAPVITGLQ----NLVGTKRVSDPSQKN---------SGTDM--EPRTVEINRELSDAL 1687
Query: 563 GFSILDYQDPVDPNGTV-IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQ 621
G SI + P G + + + + GVA + ++ GDR++S+NG + + V
Sbjct: 1688 GISIAGGRG--SPIGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVN 1745
Query: 622 ALKGA 626
LK A
Sbjct: 1746 LLKNA 1750
Score = 35.5 bits (78), Expect = 0.60
Identities = 21/73 (28%), Positives = 39/73 (53%), Gaps = 1/73 (1%)
Query: 199 VDLNKNVY-GLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLA 257
V++N+ + LGI++AG +F+ I A ++ K+K+ DRI+ ++G L
Sbjct: 1677 VEINRELSDALGISIAGGRGSPIGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLD 1736
Query: 258 DKSNPQSVEILRN 270
S+ V +L+N
Sbjct: 1737 GLSHADVVNLLKN 1749
Score = 34.7 bits (76), Expect = 1.0
Identities = 23/84 (27%), Positives = 43/84 (51%), Gaps = 7/84 (8%)
Query: 13 VELTND-GNGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLR 66
VE+ + + LG ++ GGR + V I + GVA + ++L+ GD ++ + L
Sbjct: 1677 VEINRELSDALGISIAGGRGSPIGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLD 1736
Query: 67 GFTSEQVAAVLRQA-GPVVRLLVA 89
G + V +L+ A G ++ +VA
Sbjct: 1737 GLSHADVVNLLKNAYGRIILQVVA 1760
>AB044807-1|BAB19683.1| 1134|Homo sapiens PDZ domain protein 3'
variant 4 protein.
Length = 1134
Score = 114 bits (274), Expect = 1e-24
Identities = 55/105 (52%), Positives = 74/105 (70%)
Query: 543 LAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDR 602
LA+W + IV LVK +GLGFSILDYQDP+DP +VIV+RSLV GVAE++G + PGDR
Sbjct: 136 LALWSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDR 195
Query: 603 VMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPLPPQDSSKS 647
++SVN + N +L +AV+ LK P G V +GI +PL + +S
Sbjct: 196 LVSVNEYCLDNTSLAEAVEILKAVPPGLVHLGICKPLVEDNEEES 240
Score = 89.8 bits (213), Expect = 3e-17
Identities = 72/275 (26%), Positives = 128/275 (46%), Gaps = 29/275 (10%)
Query: 198 HVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLA 257
+V L ++ G G TV + EEL GIF+K ++E S A ++ +K D+I+EV G+ L
Sbjct: 535 NVSLGISIVG-GQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQ 593
Query: 258 DKSNPQSVEILRNTGISVHLVLERYLRGPKFEHLQLAIFNEERXXXXXXXXXXLSWFPVP 317
+ S+ ++VE ++N G V +++ P+ I N
Sbjct: 594 NASHSEAVEAIKNAGNPVVFIVQSLSSTPR------VIPNVHNKANKITGN--------- 638
Query: 318 SQLENSITEIEPEPESNTTIDSSVLEVGDLQEPTQEELDQRFDEILAVDKEDIVKKWKEE 377
+N T+ + E T +++ + ++ D+ +E D++ +++ +
Sbjct: 639 ---QNQDTQEKKEKRQGTA--PPPMKLPPPYKALTDDSDENEEEDAFTDQK--IRQRYAD 691
Query: 378 IGSDKEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDE 437
+ + I+ E K GLG+SL G D R ++ + P+GP G ++ GDE
Sbjct: 692 LPGELHIIELE-KDKNGLGLSLAGNKD-----RSRMSIFVVGINPEGPAAADGRMHIGDE 745
Query: 438 LLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARN 472
LLE+N L+G +H I+K P +V+LV RN
Sbjct: 746 LLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRN 780
Score = 71.7 bits (168), Expect = 7e-12
Identities = 64/287 (22%), Positives = 133/287 (46%), Gaps = 18/287 (6%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTGVVIKYVL---PGGVADKDRRLQSGDHVLQVGSVNL 65
++ ++EL D NGLG +L G + + +V+ P G A D R+ GD +L++ + L
Sbjct: 695 ELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMHIGDELLEINNQIL 754
Query: 66 RGFTSEQVAAVLRQAGPVVRLLVARPADPATALRA---PQPGTALVPTKILADPELLDRH 122
G + + +A+++ A V+L+ R D + P P ++ + + E +
Sbjct: 755 YGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSE 814
Query: 123 ---LIETGYGAVYDLSQC-YSDYNINGQNGETETSIVAAAVSVIGDNPQKIPDHPIV-CD 177
+E G + + + + Q T+ S + + + + D
Sbjct: 815 EDGSLEVGIKQLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYG 874
Query: 178 SVSPTITI---TVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGS 234
+++ T P+ +P E+I ++++K GLG+++ G + L+ I + + E
Sbjct: 875 GFQAPLSVDPATCPI-VPGQEMI-IEISKGRSGLGLSIVGG--KDTPLNAIVIHEVYEEG 930
Query: 235 SAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
+A + G++ D+I+EV+G+ L + S+ +++ LR T V LV+ R
Sbjct: 931 AAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYR 977
Score = 62.5 bits (145), Expect = 5e-09
Identities = 29/62 (46%), Positives = 38/62 (61%)
Query: 414 HHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNS 473
HHYI S++ GPV G+L DELLEVN +L+G + E V+ LK++P LVC R
Sbjct: 39 HHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRL 98
Query: 474 ID 475
D
Sbjct: 99 FD 100
Score = 59.3 bits (137), Expect = 4e-08
Identities = 65/245 (26%), Positives = 109/245 (44%), Gaps = 24/245 (9%)
Query: 395 LGISLEGTVDV----EGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLT 450
LGIS+ G V + G+EL+ +I+ VL D P G L GD++LEV+ L +
Sbjct: 538 LGISIVGGQTVIKRLKNGEELKGI-FIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNAS 596
Query: 451 HSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKA 510
HSE V +K + V + S+ S PR + N+ + +A K I+G+ N T K
Sbjct: 597 HSEAVEAIKNAGNPVVFIV--QSLSSTPRVIPNVHN-----KANK-ITGNQNQDTQEKKE 648
Query: 511 QSDTSINTSST-----ATLTNHSEQSKKSRSL---ECVSGLAMWQSKEDIVMLVKADQGL 562
+ + LT+ S+++++ + + A + I+ L K GL
Sbjct: 649 KRQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGL 708
Query: 563 GFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQA 622
G S+ + D + I V + P G A +G + GD ++ +N + + A
Sbjct: 709 GLSLAGNK---DRSRMSIFVVGINPEGPAAADGRMHIGDELLEINNQILYGRSHQNASAI 765
Query: 623 LKGAP 627
+K AP
Sbjct: 766 IKTAP 770
Score = 57.6 bits (133), Expect = 1e-07
Identities = 30/73 (41%), Positives = 45/73 (61%), Gaps = 1/73 (1%)
Query: 19 GNGLGFNLVGGRS-TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAVL 77
G GLG ++VG R+ +GV I ++ GG AD D RL GD +L V ++R + E VA +L
Sbjct: 1000 GRGLGLSIVGKRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATIL 1059
Query: 78 RQAGPVVRLLVAR 90
+ A +V+L + R
Sbjct: 1060 KCAQGLVQLEIGR 1072
Score = 51.6 bits (118), Expect = 9e-06
Identities = 29/81 (35%), Positives = 49/81 (60%), Gaps = 6/81 (7%)
Query: 557 KADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATL 616
KA +GLG SI+ + NG+ + + +V GG A+ +G + GD+++SVNG ++NA+
Sbjct: 998 KAGRGLGLSIVGKR-----NGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQ 1052
Query: 617 DQAVQALKGAPRGTVKVGIAR 637
+ LK A +G V++ I R
Sbjct: 1053 ETVATILKCA-QGLVQLEIGR 1072
Score = 50.8 bits (116), Expect = 1e-05
Identities = 26/81 (32%), Positives = 50/81 (61%), Gaps = 5/81 (6%)
Query: 549 KEDIVMLVKADQGLGFSILDYQD-PVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVN 607
+E I+ + K GLG SI+ +D P++ IV+ + G A ++G + GD+++ VN
Sbjct: 893 QEMIIEISKGRSGLGLSIVGGKDTPLN----AIVIHEVYEEGAAARDGRLWAGDQILEVN 948
Query: 608 GVSIQNATLDQAVQALKGAPR 628
GV ++N++ ++A+ AL+ P+
Sbjct: 949 GVDLRNSSHEEAITALRQTPQ 969
Score = 50.4 bits (115), Expect = 2e-05
Identities = 31/91 (34%), Positives = 46/91 (50%), Gaps = 5/91 (5%)
Query: 382 KEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEV 441
+E+++ K GLG+S+ G D + I V +G G L AGD++LEV
Sbjct: 893 QEMIIEISKGRSGLGLSIVGGKDTPLNAIV-----IHEVYEEGAAARDGRLWAGDQILEV 947
Query: 442 NEYRLHGLTHSEVVNILKQLPDRVRLVCARN 472
N L +H E + L+Q P +VRLV R+
Sbjct: 948 NGVDLRNSSHEEAITALRQTPQKVRLVVYRD 978
Score = 46.4 bits (105), Expect = 3e-04
Identities = 29/93 (31%), Positives = 48/93 (51%), Gaps = 5/93 (5%)
Query: 194 IEIIHVDLNKNV-YGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVD 252
+EI VDL K GLG+++ G K SG+F+ I++G +A+ G++ D+I+ V+
Sbjct: 988 LEIFPVDLQKKAGRGLGLSIVG----KRNGSGVFISDIVKGGAADLDGRLIQGDQILSVN 1043
Query: 253 GISLADKSNPQSVEILRNTGISVHLVLERYLRG 285
G + + S IL+ V L + R G
Sbjct: 1044 GEDMRNASQETVATILKCAQGLVQLEIGRLRAG 1076
Score = 45.6 bits (103), Expect = 6e-04
Identities = 35/111 (31%), Positives = 50/111 (45%), Gaps = 7/111 (6%)
Query: 352 QEELDQRFDEILAVDKEDIVKKWKEEIGSDKEILVAEIKKLEGLGISLEGTVDVEGGQEL 411
+ E+D D D + + W E+ +V +K +GLG S+ D
Sbjct: 117 ETEVDHNMDVNTEEDDDGELALWSPEVK-----IVELVKDCKGLGFSILDYQDPL--DPT 169
Query: 412 RPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP 462
R IRS++ DG G L GD L+ VNEY L + +E V ILK +P
Sbjct: 170 RSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAVP 220
Score = 43.6 bits (98), Expect = 0.002
Identities = 32/123 (26%), Positives = 59/123 (47%), Gaps = 6/123 (4%)
Query: 509 KAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILD 568
KA + T + +S AT T + ++ E + W + + + + LG SI+
Sbjct: 486 KASAYTGMLSSRYATDTCELPEREEGEGEE-TPNFSHWGPPRIVEIFREPNVSLGISIVG 544
Query: 569 YQDPVD--PNGTV---IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQAL 623
Q + NG I ++ ++ A K + GD+++ V+GV +QNA+ +AV+A+
Sbjct: 545 GQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAI 604
Query: 624 KGA 626
K A
Sbjct: 605 KNA 607
Score = 41.5 bits (93), Expect = 0.009
Identities = 26/79 (32%), Positives = 46/79 (58%), Gaps = 3/79 (3%)
Query: 192 PEIEIIHVDLNKNVYGLGITVAGYVCEKEEL-SGIFVKSIIEGSSAEQSGKIKINDRIIE 250
PE++I V+L K+ GLG ++ Y + S I ++S++ AE+SG + DR++
Sbjct: 141 PEVKI--VELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVS 198
Query: 251 VDGISLADKSNPQSVEILR 269
V+ L + S ++VEIL+
Sbjct: 199 VNEYCLDNTSLAEAVEILK 217
Score = 38.3 bits (85), Expect = 0.085
Identities = 25/93 (26%), Positives = 49/93 (52%), Gaps = 8/93 (8%)
Query: 7 WA-QVEVVELTNDGNGLGFNLVGGRS------TGVVIKYVLPGGVADKDRRLQSGDHVLQ 59
W+ +V++VEL D GLGF+++ + + +VI+ ++ GVA++ L GD ++
Sbjct: 139 WSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVS 198
Query: 60 VGSVNLRGFTSEQVAAVLRQAGP-VVRLLVARP 91
V L + + +L+ P +V L + +P
Sbjct: 199 VNEYCLDNTSLAEAVEILKAVPPGLVHLGICKP 231
Score = 33.9 bits (74), Expect = 1.8
Identities = 17/58 (29%), Positives = 30/58 (51%)
Query: 226 FVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLERYL 283
++ SI+ G + G ++ D ++EV+G+ L KS ++V L+ LV R L
Sbjct: 41 YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRL 98
Score = 33.9 bits (74), Expect = 1.8
Identities = 15/46 (32%), Positives = 25/46 (54%)
Query: 582 VRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAP 627
+ S+V GG + G + P D ++ VNG+ + + +AV LK P
Sbjct: 42 ISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVP 87
Score = 32.7 bits (71), Expect = 4.2
Identities = 25/89 (28%), Positives = 38/89 (42%), Gaps = 5/89 (5%)
Query: 383 EILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVN 442
EI +++K G G+ L V G + +I ++ G L G L GD++L VN
Sbjct: 989 EIFPVDLQKKAGRGLGLS-IVGKRNGSGV----FISDIVKGGAADLDGRLIQGDQILSVN 1043
Query: 443 EYRLHGLTHSEVVNILKQLPDRVRLVCAR 471
+ + V ILK V+L R
Sbjct: 1044 GEDMRNASQETVATILKCAQGLVQLEIGR 1072
>AK126776-1|BAC86685.1| 749|Homo sapiens protein ( Homo sapiens
cDNA FLJ44824 fis, clone BRACE3046491, highly similar
to Channel associated protein of synapse-110. ).
Length = 749
Score = 87.0 bits (206), Expect = 2e-16
Identities = 83/282 (29%), Positives = 129/282 (45%), Gaps = 26/282 (9%)
Query: 386 VAEIKKLEG---LGISLEGTVDVEGGQELRPHH--YIRSVLPDGPVGLQGVLNAGDELLE 440
V EIK +G LG S+ G V G Q + + Y+ ++ G G L GD LL
Sbjct: 140 VVEIKLFKGPKGLGFSIAGGV---GNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLM 196
Query: 441 VNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSI-----DSGPRPVVNLASDREGFEARK 495
VN Y L +TH E V ILK + V L + + GP + + S
Sbjct: 197 VNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLS 256
Query: 496 IISGSLNNLTTLVKAQ----SDTSINTSSTATLTNHSEQSKKSRSLECVSGLAM-WQSKE 550
+G+L T+L S + T+HS+ S +R A+ + +
Sbjct: 257 GNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEGEP 316
Query: 551 DIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVS 610
V+L K GLGF+I+ +D G I V ++ GG A+ +GE+ GD+++SVNG+
Sbjct: 317 RKVVLHKGSTGLGFNIVGGED-----GEGIFVSFILAGGPADLSGELQRGDQILSVNGID 371
Query: 611 IQNATLDQAVQALKGAPRGTVKVGIARPLPPQDSSKSKGTIN 652
++ A+ +QA ALKGA + V I P+D ++ + I+
Sbjct: 372 LRGASHEQAAAALKGAGQ---TVTIIAQYQPEDYARFEAKIH 410
Score = 81.8 bits (193), Expect = 7e-15
Identities = 78/286 (27%), Positives = 126/286 (44%), Gaps = 50/286 (17%)
Query: 13 VELTNDGNGLGFNLVGG-------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
++L GLGF++ GG + + ++ GG A KD RLQ GD +L V + +L
Sbjct: 143 IKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSL 202
Query: 66 RGFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVPTKILADPELLDRHLIE 125
T E+ A+L+ VV L V +P T + T P++
Sbjct: 203 EEVTHEEAVAILKNTSEVVYLKVGKP-------------TTIYMTDPYGPPDI------- 242
Query: 126 TGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQKIPDHPIVCDSVS----- 180
+ S ++ ++G NG E +S +P IP H +V D +
Sbjct: 243 -----THSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSP--IPKHMLVDDDYTSHSQH 295
Query: 181 ------PTITITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGS 234
P++T+ V L E E V L+K GLG + G E+ GIFV I+ G
Sbjct: 296 STATRQPSMTLQRAVSL-EGEPRKVVLHKGSTGLGFNIVG----GEDGEGIFVSFILAGG 350
Query: 235 SAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLE 280
A+ SG+++ D+I+ V+GI L S+ Q+ L+ G +V ++ +
Sbjct: 351 PADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQ 396
Score = 68.9 bits (161), Expect = 5e-11
Identities = 36/85 (42%), Positives = 49/85 (57%), Gaps = 2/85 (2%)
Query: 13 VELTNDGNGLGFNLVGGRS-TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSE 71
V L GLGFN+VGG G+ + ++L GG AD LQ GD +L V ++LRG + E
Sbjct: 319 VVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHE 378
Query: 72 QVAAVLRQAGPVVRLLVA-RPADPA 95
Q AA L+ AG V ++ +P D A
Sbjct: 379 QAAAALKGAGQTVTIIAQYQPEDYA 403
Score = 55.2 bits (127), Expect = 7e-07
Identities = 31/99 (31%), Positives = 55/99 (55%), Gaps = 4/99 (4%)
Query: 187 VPVELPEIE--IIHVDLNKNVYGLGITVAGYVCEKE--ELSGIFVKSIIEGSSAEQSGKI 242
+PV EIE + L + GLG ++AG + GIF+ II G +A + G++
Sbjct: 34 IPVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRL 93
Query: 243 KINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
++ND I+ V+ + +++ S+ ++VE L+ G V L + R
Sbjct: 94 RVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRR 132
Score = 55.2 bits (127), Expect = 7e-07
Identities = 29/89 (32%), Positives = 48/89 (53%), Gaps = 7/89 (7%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRST-------GVVIKYVLPGGVADKDRRLQSGDHVLQVG 61
+ E + L +GLGF++ GG G+ I ++PGG A +D RL+ D +L+V
Sbjct: 44 EFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVN 103
Query: 62 SVNLRGFTSEQVAAVLRQAGPVVRLLVAR 90
V++ + + L++AG +VRL V R
Sbjct: 104 EVDVSEVSHSKAVEALKEAGSIVRLYVRR 132
Score = 55.2 bits (127), Expect = 7e-07
Identities = 28/85 (32%), Positives = 54/85 (63%), Gaps = 4/85 (4%)
Query: 196 IIHVDLNKNVYGLGITVAGYVCEKEELSG---IFVKSIIEGSSAEQSGKIKINDRIIEVD 252
++ + L K GLG ++AG V + + G I+V II+G +A++ G++++ DR++ V+
Sbjct: 140 VVEIKLFKGPKGLGFSIAGGV-GNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVN 198
Query: 253 GISLADKSNPQSVEILRNTGISVHL 277
SL + ++ ++V IL+NT V+L
Sbjct: 199 NYSLEEVTHEEAVAILKNTSEVVYL 223
Score = 47.2 bits (107), Expect = 2e-04
Identities = 29/88 (32%), Positives = 47/88 (53%), Gaps = 2/88 (2%)
Query: 540 VSGLAMWQSKEDIVMLVKADQGLGFSILDYQD-PVDPNGTVIVVRSLVPGGVAEKNGEIS 598
V+G + E+I L + + GLGFSI D P + I + ++PGG A ++G +
Sbjct: 36 VNGTEIEYEFEEIT-LERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLR 94
Query: 599 PGDRVMSVNGVSIQNATLDQAVQALKGA 626
D ++ VN V + + +AV+ALK A
Sbjct: 95 VNDCILRVNEVDVSEVSHSKAVEALKEA 122
Score = 41.5 bits (93), Expect = 0.009
Identities = 27/79 (34%), Positives = 38/79 (48%), Gaps = 3/79 (3%)
Query: 394 GLGISLEGTVDVEG-GQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHS 452
GLG S+ G D G + P +I ++P G G L D +L VNE + ++HS
Sbjct: 56 GLGFSIAGGTDNPHIGDD--PGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHS 113
Query: 453 EVVNILKQLPDRVRLVCAR 471
+ V LK+ VRL R
Sbjct: 114 KAVEALKEAGSIVRLYVRR 132
>AK123038-1|BAC85520.1| 1284|Homo sapiens protein ( Homo sapiens cDNA
FLJ41043 fis, clone NT2RP7000359, weakly similar to
PROTEIN-TYROSINE PHOSPHATASE D1 (EC 3.1.3.48). ).
Length = 1284
Score = 82.2 bits (194), Expect = 5e-15
Identities = 70/238 (29%), Positives = 107/238 (44%), Gaps = 12/238 (5%)
Query: 413 PHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARN 472
P +I S++P GP + G ++L +N L G T + V +++ PD + L+ +++
Sbjct: 776 PGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSPDNIELIISQS 835
Query: 473 SIDSGPRPVVNL-ASDREGFEARKIIS----GSLNNLTTLVKAQSDT--SINTSSTATLT 525
G P + G + I+S GSL++ T ++ S
Sbjct: 836 KGVGGNNPDEEKNGTANSGVSSTDILSFGYQGSLSSHTQDQDRNTEELDMAGVQSLVPRL 895
Query: 526 NH--SEQSKKSRSLECVSGLAMWQSKED-IVMLVKADQGLGFSILDYQDPVDPNGTVIVV 582
H S K C + E V LVK D LGFS+ + P G I V
Sbjct: 896 RHQLSFLPLKGAGSSCPPSPPEISAGEIYFVELVKEDGTLGFSVTGGINTSVPYGG-IYV 954
Query: 583 RSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPLP 640
+S+VPGG A K G+I GDR++ V+GV + T QAVQ LKG P ++ + R +P
Sbjct: 955 KSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLKG-PGQVARLVLERRVP 1011
Score = 80.6 bits (190), Expect = 2e-14
Identities = 67/256 (26%), Positives = 118/256 (46%), Gaps = 21/256 (8%)
Query: 28 GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAVLRQAGPVVRLL 87
G G+ I ++PGG A+K + ++ G +L + ++L GFT +++ + + L+
Sbjct: 772 GQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSPDNIELI 831
Query: 88 VARPADPATALRAPQPGTALVPTKILADPELLDRHLIETGYGAVYDLSQCYSDYNINGQN 147
+++ + + P T A+ + ++ GY LS D Q+
Sbjct: 832 ISQ----SKGVGGNNPDEEKNGT---ANSGVSSTDILSFGYQG--SLSSHTQD-----QD 877
Query: 148 GETETSIVAAAVSVIGDNPQKIPDHPI--VCDSVSPTITITVPVELPEIEIIHVDLNKNV 205
TE +A S++ ++ P+ S P+ P E+ EI V+L K
Sbjct: 878 RNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPS-----PPEISAGEIYFVELVKED 932
Query: 206 YGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSV 265
LG +V G + GI+VKSI+ G A + G+I DR+++VDG+ L ++ Q+V
Sbjct: 933 GTLGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAV 992
Query: 266 EILRNTGISVHLVLER 281
+ L+ G LVLER
Sbjct: 993 QCLKGPGQVARLVLER 1008
Score = 60.5 bits (140), Expect = 2e-08
Identities = 33/93 (35%), Positives = 52/93 (55%), Gaps = 5/93 (5%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRST-----GVVIKYVLPGGVADKDRRLQSGDHVLQVGSV 63
++ VEL + LGF++ GG +T G+ +K ++PGG A K+ ++ GD +LQV V
Sbjct: 922 EIYFVELVKEDGTLGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGV 981
Query: 64 NLRGFTSEQVAAVLRQAGPVVRLLVARPADPAT 96
L G T +Q L+ G V RL++ R +T
Sbjct: 982 ILCGLTHKQAVQCLKGPGQVARLVLERRVPRST 1014
Score = 51.6 bits (118), Expect = 9e-06
Identities = 30/90 (33%), Positives = 49/90 (54%), Gaps = 3/90 (3%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPN--GTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVS 610
V L K GLGFS + + + ++ ++ L PG AE+NG I+ GD +++VNG S
Sbjct: 1055 VKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 1114
Query: 611 IQNATLDQAVQALKGAPRGTVKVGIARPLP 640
+ + + L+GAP+ V + + RP P
Sbjct: 1115 TEGLIFQEVLHLLRGAPQ-EVTLLLCRPPP 1143
Score = 50.0 bits (114), Expect = 3e-05
Identities = 27/83 (32%), Positives = 49/83 (59%), Gaps = 7/83 (8%)
Query: 549 KEDIVMLVKAD--QGLGFSILD--YQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVM 604
+E + + +K D +G GF I + Y DP I + S++PGG AEK I PG +++
Sbjct: 746 REIVRVTLKRDPHRGFGFVINEGEYSGQADPG---IFISSIIPGGPAEKAKTIKPGGQIL 802
Query: 605 SVNGVSIQNATLDQAVQALKGAP 627
++N +S++ T + AV+ ++ +P
Sbjct: 803 ALNHISLEGFTFNMAVRMIQNSP 825
Score = 41.5 bits (93), Expect = 0.009
Identities = 25/91 (27%), Positives = 49/91 (53%), Gaps = 1/91 (1%)
Query: 192 PEIEIIHVDLNKNVY-GLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIE 250
P EI+ V L ++ + G G + + GIF+ SII G AE++ IK +I+
Sbjct: 744 PGREIVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILA 803
Query: 251 VDGISLADKSNPQSVEILRNTGISVHLVLER 281
++ ISL + +V +++N+ ++ L++ +
Sbjct: 804 LNHISLEGFTFNMAVRMIQNSPDNIELIISQ 834
Score = 41.5 bits (93), Expect = 0.009
Identities = 29/87 (33%), Positives = 45/87 (51%), Gaps = 8/87 (9%)
Query: 13 VELTNDGNGLGFNLVGG--------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V+L + NGLGF+ V +S V IK + PG A+++ + +GD +L V +
Sbjct: 1055 VKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 1114
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARP 91
G ++V +LR A V LL+ RP
Sbjct: 1115 TEGLIFQEVLHLLRGAPQEVTLLLCRP 1141
Score = 33.5 bits (73), Expect = 2.4
Identities = 28/88 (31%), Positives = 40/88 (45%), Gaps = 7/88 (7%)
Query: 199 VDLNKNVYGLGITVAGYVCEKEELSG-----IFVKSIIEGSSAEQSGKIKINDRIIEVDG 253
V L KN GLG + EKE S + +K + G AE++G I D I+ V+G
Sbjct: 1055 VKLKKNANGLGFSFVQM--EKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNG 1112
Query: 254 ISLADKSNPQSVEILRNTGISVHLVLER 281
S + + +LR V L+L R
Sbjct: 1113 RSTEGLIFQEVLHLLRGAPQEVTLLLCR 1140
>U13897-1|AAA50599.1| 904|Homo sapiens homolog of Drosophila discs
large protein, isoform 1 protein.
Length = 904
Score = 79.8 bits (188), Expect = 3e-14
Identities = 79/261 (30%), Positives = 119/261 (45%), Gaps = 29/261 (11%)
Query: 380 SDKEILVAEIKKLEGLGISLEGTVDVEGGQELRPHH--YIRSVLPDGPVGLQGVLNAGDE 437
S+K + + IK +GLG S+ G V G Q + + Y+ ++ G G L GD+
Sbjct: 314 SEKIMEIKLIKGPKGLGFSIAGGV---GNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDK 370
Query: 438 LLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKII 497
LL VN L +TH E V LK D V L A+ P +D G+ I
Sbjct: 371 LLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAK--------PTSMYMND--GYAPPDIT 420
Query: 498 SGSLNNLTTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVK 557
+ S + V S +S + A+ +S SK V G + V+L +
Sbjct: 421 NSSSQPVDNHV---SPSSFLGQTPASPARYSPVSK------AVLGDDEITREPRKVVLHR 471
Query: 558 ADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLD 617
GLGF+I+ +D G I + ++ GG A+ +GE+ GDR++SVN V ++ A+ +
Sbjct: 472 GSTGLGFNIVGGED-----GEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHE 526
Query: 618 QAVQALKGAPRGTVKVGIARP 638
QA ALK A + V RP
Sbjct: 527 QAAAALKNAGQAVTIVAQYRP 547
Score = 66.9 bits (156), Expect = 2e-10
Identities = 35/83 (42%), Positives = 48/83 (57%), Gaps = 2/83 (2%)
Query: 13 VELTNDGNGLGFNLVGGRS-TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSE 71
V L GLGFN+VGG G+ I ++L GG AD L+ GD ++ V SV+LR + E
Sbjct: 467 VVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHE 526
Query: 72 QVAAVLRQAGPVVRLLVA-RPAD 93
Q AA L+ AG V ++ RP +
Sbjct: 527 QAAAALKNAGQAVTIVAQYRPEE 549
Score = 56.0 bits (129), Expect = 4e-07
Identities = 30/89 (33%), Positives = 48/89 (53%), Gaps = 7/89 (7%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRS-------TGVVIKYVLPGGVADKDRRLQSGDHVLQVG 61
+ E + L +GLGF++ GG + + I ++ GG A +D RL+ D +LQV
Sbjct: 221 EYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILQVN 280
Query: 62 SVNLRGFTSEQVAAVLRQAGPVVRLLVAR 90
V++R T + L++AG +VRL V R
Sbjct: 281 EVDVRDVTHSKAVEALKEAGSIVRLYVKR 309
Score = 54.8 bits (126), Expect = 9e-07
Identities = 28/91 (30%), Positives = 52/91 (57%), Gaps = 2/91 (2%)
Query: 193 EIEIIHVDLNKNVYGLGITVAGYVCEKE--ELSGIFVKSIIEGSSAEQSGKIKINDRIIE 250
+ E + L + GLG ++AG + S IF+ II G +A Q G++++ND I++
Sbjct: 219 DYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILQ 278
Query: 251 VDGISLADKSNPQSVEILRNTGISVHLVLER 281
V+ + + D ++ ++VE L+ G V L ++R
Sbjct: 279 VNEVDVRDVTHSKAVEALKEAGSIVRLYVKR 309
Score = 54.0 bits (124), Expect = 2e-06
Identities = 29/86 (33%), Positives = 53/86 (61%), Gaps = 4/86 (4%)
Query: 195 EIIHVDLNKNVYGLGITVAGYVCEKEELSG---IFVKSIIEGSSAEQSGKIKINDRIIEV 251
+I+ + L K GLG ++AG V + + G I+V IIEG +A + GK++I D+++ V
Sbjct: 316 KIMEIKLIKGPKGLGFSIAGGV-GNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAV 374
Query: 252 DGISLADKSNPQSVEILRNTGISVHL 277
+ + L + ++ ++V L+NT V+L
Sbjct: 375 NNVCLEEVTHEEAVTALKNTSDFVYL 400
Score = 50.8 bits (116), Expect = 1e-05
Identities = 28/82 (34%), Positives = 46/82 (56%), Gaps = 4/82 (4%)
Query: 199 VDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLAD 258
V L++ GLG + G E+ GIF+ I+ G A+ SG+++ DRII V+ + L
Sbjct: 467 VVLHRGSTGLGFNIVG----GEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRA 522
Query: 259 KSNPQSVEILRNTGISVHLVLE 280
S+ Q+ L+N G +V +V +
Sbjct: 523 ASHEQAAAALKNAGQAVTIVAQ 544
Score = 49.6 bits (113), Expect = 3e-05
Identities = 28/86 (32%), Positives = 42/86 (48%), Gaps = 7/86 (8%)
Query: 13 VELTNDGNGLGFNLVGG-------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
++L GLGF++ GG + + ++ GG A KD +LQ GD +L V +V L
Sbjct: 320 IKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCL 379
Query: 66 RGFTSEQVAAVLRQAGPVVRLLVARP 91
T E+ L+ V L VA+P
Sbjct: 380 EEVTHEEAVTALKNTSDFVYLKVAKP 405
Score = 47.6 bits (108), Expect = 1e-04
Identities = 25/75 (33%), Positives = 43/75 (57%), Gaps = 1/75 (1%)
Query: 553 VMLVKADQGLGFSILDYQD-PVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSI 611
+ L + + GLGFSI D P + + I + ++ GG A ++G + D ++ VN V +
Sbjct: 225 ITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILQVNEVDV 284
Query: 612 QNATLDQAVQALKGA 626
++ T +AV+ALK A
Sbjct: 285 RDVTHSKAVEALKEA 299
Score = 39.1 bits (87), Expect = 0.049
Identities = 26/79 (32%), Positives = 37/79 (46%), Gaps = 3/79 (3%)
Query: 394 GLGISLEGTVDVEG-GQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHS 452
GLG S+ G D G + +I ++ G G L D +L+VNE + +THS
Sbjct: 233 GLGFSIAGGTDNPHIGDD--SSIFITKIITGGAAAQDGRLRVNDCILQVNEVDVRDVTHS 290
Query: 453 EVVNILKQLPDRVRLVCAR 471
+ V LK+ VRL R
Sbjct: 291 KAVEALKEAGSIVRLYVKR 309
>U13896-1|AAA50598.1| 926|Homo sapiens homolog of Drosophila discs
large protein, isoform 2 protein.
Length = 926
Score = 79.8 bits (188), Expect = 3e-14
Identities = 79/261 (30%), Positives = 119/261 (45%), Gaps = 29/261 (11%)
Query: 380 SDKEILVAEIKKLEGLGISLEGTVDVEGGQELRPHH--YIRSVLPDGPVGLQGVLNAGDE 437
S+K + + IK +GLG S+ G V G Q + + Y+ ++ G G L GD+
Sbjct: 314 SEKIMEIKLIKGPKGLGFSIAGGV---GNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDK 370
Query: 438 LLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKII 497
LL VN L +TH E V LK D V L A+ P +D G+ I
Sbjct: 371 LLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAK--------PTSMYMND--GYAPPDIT 420
Query: 498 SGSLNNLTTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVK 557
+ S + V S +S + A+ +S SK V G + V+L +
Sbjct: 421 NSSSQPVDNHV---SPSSFLGQTPASPARYSPVSK------AVLGDDEITREPRKVVLHR 471
Query: 558 ADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLD 617
GLGF+I+ +D G I + ++ GG A+ +GE+ GDR++SVN V ++ A+ +
Sbjct: 472 GSTGLGFNIVGGED-----GEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHE 526
Query: 618 QAVQALKGAPRGTVKVGIARP 638
QA ALK A + V RP
Sbjct: 527 QAAAALKNAGQAVTIVAQYRP 547
Score = 66.9 bits (156), Expect = 2e-10
Identities = 35/83 (42%), Positives = 48/83 (57%), Gaps = 2/83 (2%)
Query: 13 VELTNDGNGLGFNLVGGRS-TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSE 71
V L GLGFN+VGG G+ I ++L GG AD L+ GD ++ V SV+LR + E
Sbjct: 467 VVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHE 526
Query: 72 QVAAVLRQAGPVVRLLVA-RPAD 93
Q AA L+ AG V ++ RP +
Sbjct: 527 QAAAALKNAGQAVTIVAQYRPEE 549
Score = 56.0 bits (129), Expect = 4e-07
Identities = 30/89 (33%), Positives = 48/89 (53%), Gaps = 7/89 (7%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRS-------TGVVIKYVLPGGVADKDRRLQSGDHVLQVG 61
+ E + L +GLGF++ GG + + I ++ GG A +D RL+ D +LQV
Sbjct: 221 EYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILQVN 280
Query: 62 SVNLRGFTSEQVAAVLRQAGPVVRLLVAR 90
V++R T + L++AG +VRL V R
Sbjct: 281 EVDVRDVTHSKAVEALKEAGSIVRLYVKR 309
Score = 54.8 bits (126), Expect = 9e-07
Identities = 28/91 (30%), Positives = 52/91 (57%), Gaps = 2/91 (2%)
Query: 193 EIEIIHVDLNKNVYGLGITVAGYVCEKE--ELSGIFVKSIIEGSSAEQSGKIKINDRIIE 250
+ E + L + GLG ++AG + S IF+ II G +A Q G++++ND I++
Sbjct: 219 DYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILQ 278
Query: 251 VDGISLADKSNPQSVEILRNTGISVHLVLER 281
V+ + + D ++ ++VE L+ G V L ++R
Sbjct: 279 VNEVDVRDVTHSKAVEALKEAGSIVRLYVKR 309
Score = 54.0 bits (124), Expect = 2e-06
Identities = 29/86 (33%), Positives = 53/86 (61%), Gaps = 4/86 (4%)
Query: 195 EIIHVDLNKNVYGLGITVAGYVCEKEELSG---IFVKSIIEGSSAEQSGKIKINDRIIEV 251
+I+ + L K GLG ++AG V + + G I+V IIEG +A + GK++I D+++ V
Sbjct: 316 KIMEIKLIKGPKGLGFSIAGGV-GNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAV 374
Query: 252 DGISLADKSNPQSVEILRNTGISVHL 277
+ + L + ++ ++V L+NT V+L
Sbjct: 375 NNVCLEEVTHEEAVTALKNTSDFVYL 400
Score = 50.8 bits (116), Expect = 1e-05
Identities = 28/82 (34%), Positives = 46/82 (56%), Gaps = 4/82 (4%)
Query: 199 VDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLAD 258
V L++ GLG + G E+ GIF+ I+ G A+ SG+++ DRII V+ + L
Sbjct: 467 VVLHRGSTGLGFNIVG----GEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRA 522
Query: 259 KSNPQSVEILRNTGISVHLVLE 280
S+ Q+ L+N G +V +V +
Sbjct: 523 ASHEQAAAALKNAGQAVTIVAQ 544
Score = 49.6 bits (113), Expect = 3e-05
Identities = 28/86 (32%), Positives = 42/86 (48%), Gaps = 7/86 (8%)
Query: 13 VELTNDGNGLGFNLVGG-------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
++L GLGF++ GG + + ++ GG A KD +LQ GD +L V +V L
Sbjct: 320 IKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCL 379
Query: 66 RGFTSEQVAAVLRQAGPVVRLLVARP 91
T E+ L+ V L VA+P
Sbjct: 380 EEVTHEEAVTALKNTSDFVYLKVAKP 405
Score = 47.6 bits (108), Expect = 1e-04
Identities = 25/75 (33%), Positives = 43/75 (57%), Gaps = 1/75 (1%)
Query: 553 VMLVKADQGLGFSILDYQD-PVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSI 611
+ L + + GLGFSI D P + + I + ++ GG A ++G + D ++ VN V +
Sbjct: 225 ITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILQVNEVDV 284
Query: 612 QNATLDQAVQALKGA 626
++ T +AV+ALK A
Sbjct: 285 RDVTHSKAVEALKEA 299
Score = 39.1 bits (87), Expect = 0.049
Identities = 26/79 (32%), Positives = 37/79 (46%), Gaps = 3/79 (3%)
Query: 394 GLGISLEGTVDVEG-GQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHS 452
GLG S+ G D G + +I ++ G G L D +L+VNE + +THS
Sbjct: 233 GLGFSIAGGTDNPHIGDD--SSIFITKIITGGAAAQDGRLRVNDCILQVNEVDVRDVTHS 290
Query: 453 EVVNILKQLPDRVRLVCAR 471
+ V LK+ VRL R
Sbjct: 291 KAVEALKEAGSIVRLYVKR 309
>AB209536-1|BAD92773.1| 687|Homo sapiens Presynaptic protein SAP97
variant protein.
Length = 687
Score = 79.8 bits (188), Expect = 3e-14
Identities = 79/261 (30%), Positives = 119/261 (45%), Gaps = 29/261 (11%)
Query: 380 SDKEILVAEIKKLEGLGISLEGTVDVEGGQELRPHH--YIRSVLPDGPVGLQGVLNAGDE 437
S+K + + IK +GLG S+ G V G Q + + Y+ ++ G G L GD+
Sbjct: 85 SEKIMEIKLIKGPKGLGFSIAGGV---GNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDK 141
Query: 438 LLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKII 497
LL VN L +TH E V LK D V L A+ P +D G+ I
Sbjct: 142 LLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAK--------PTSMYMND--GYAPPDIT 191
Query: 498 SGSLNNLTTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVK 557
+ S + V S +S + A+ +S SK V G + V+L +
Sbjct: 192 NSSSQPVDNHV---SPSSFLGQTPASPARYSPVSK------AVLGDDEITREPRKVVLHR 242
Query: 558 ADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLD 617
GLGF+I+ +D G I + ++ GG A+ +GE+ GDR++SVN V ++ A+ +
Sbjct: 243 GSTGLGFNIVGGED-----GEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHE 297
Query: 618 QAVQALKGAPRGTVKVGIARP 638
QA ALK A + V RP
Sbjct: 298 QAAAALKNAGQAVTIVAQYRP 318
Score = 66.9 bits (156), Expect = 2e-10
Identities = 35/83 (42%), Positives = 48/83 (57%), Gaps = 2/83 (2%)
Query: 13 VELTNDGNGLGFNLVGGRS-TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSE 71
V L GLGFN+VGG G+ I ++L GG AD L+ GD ++ V SV+LR + E
Sbjct: 238 VVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHE 297
Query: 72 QVAAVLRQAGPVVRLLVA-RPAD 93
Q AA L+ AG V ++ RP +
Sbjct: 298 QAAAALKNAGQAVTIVAQYRPEE 320
Score = 54.0 bits (124), Expect = 2e-06
Identities = 29/86 (33%), Positives = 53/86 (61%), Gaps = 4/86 (4%)
Query: 195 EIIHVDLNKNVYGLGITVAGYVCEKEELSG---IFVKSIIEGSSAEQSGKIKINDRIIEV 251
+I+ + L K GLG ++AG V + + G I+V IIEG +A + GK++I D+++ V
Sbjct: 87 KIMEIKLIKGPKGLGFSIAGGV-GNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAV 145
Query: 252 DGISLADKSNPQSVEILRNTGISVHL 277
+ + L + ++ ++V L+NT V+L
Sbjct: 146 NNVCLEEVTHEEAVTALKNTSDFVYL 171
Score = 52.0 bits (119), Expect = 6e-06
Identities = 26/77 (33%), Positives = 46/77 (59%), Gaps = 2/77 (2%)
Query: 207 GLGITVAGYVCEKE--ELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQS 264
GLG ++AG + S IF+ II G +A Q G++++ND I+ V+ + + D ++ ++
Sbjct: 4 GLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKA 63
Query: 265 VEILRNTGISVHLVLER 281
VE L+ G V L ++R
Sbjct: 64 VEALKEAGSIVRLYVKR 80
Score = 51.2 bits (117), Expect = 1e-05
Identities = 27/78 (34%), Positives = 44/78 (56%), Gaps = 7/78 (8%)
Query: 20 NGLGFNLVGGRS-------TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQ 72
+GLGF++ GG + + I ++ GG A +D RL+ D +L+V V++R T +
Sbjct: 3 SGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSK 62
Query: 73 VAAVLRQAGPVVRLLVAR 90
L++AG +VRL V R
Sbjct: 63 AVEALKEAGSIVRLYVKR 80
Score = 50.8 bits (116), Expect = 1e-05
Identities = 28/82 (34%), Positives = 46/82 (56%), Gaps = 4/82 (4%)
Query: 199 VDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLAD 258
V L++ GLG + G E+ GIF+ I+ G A+ SG+++ DRII V+ + L
Sbjct: 238 VVLHRGSTGLGFNIVG----GEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRA 293
Query: 259 KSNPQSVEILRNTGISVHLVLE 280
S+ Q+ L+N G +V +V +
Sbjct: 294 ASHEQAAAALKNAGQAVTIVAQ 315
Score = 49.6 bits (113), Expect = 3e-05
Identities = 28/86 (32%), Positives = 42/86 (48%), Gaps = 7/86 (8%)
Query: 13 VELTNDGNGLGFNLVGG-------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
++L GLGF++ GG + + ++ GG A KD +LQ GD +L V +V L
Sbjct: 91 IKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCL 150
Query: 66 RGFTSEQVAAVLRQAGPVVRLLVARP 91
T E+ L+ V L VA+P
Sbjct: 151 EEVTHEEAVTALKNTSDFVYLKVAKP 176
Score = 44.8 bits (101), Expect = 0.001
Identities = 24/69 (34%), Positives = 40/69 (57%), Gaps = 1/69 (1%)
Query: 559 DQGLGFSILDYQD-PVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLD 617
+ GLGFSI D P + + I + ++ GG A ++G + D ++ VN V +++ T
Sbjct: 2 NSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHS 61
Query: 618 QAVQALKGA 626
+AV+ALK A
Sbjct: 62 KAVEALKEA 70
Score = 38.3 bits (85), Expect = 0.085
Identities = 26/79 (32%), Positives = 36/79 (45%), Gaps = 3/79 (3%)
Query: 394 GLGISLEGTVDVEG-GQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHS 452
GLG S+ G D G + +I ++ G G L D +L VNE + +THS
Sbjct: 4 GLGFSIAGGTDNPHIGDD--SSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHS 61
Query: 453 EVVNILKQLPDRVRLVCAR 471
+ V LK+ VRL R
Sbjct: 62 KAVEALKEAGSIVRLYVKR 80
>U49089-1|AAB61453.1| 817|Homo sapiens neuroendocrine-dlg protein.
Length = 817
Score = 79.4 bits (187), Expect = 4e-14
Identities = 77/254 (30%), Positives = 113/254 (44%), Gaps = 20/254 (7%)
Query: 389 IKKLEGLGISLEGTVDVEGGQELRPHH--YIRSVLPDGPVGLQGVLNAGDELLEVNEYRL 446
+K +GLG S+ G + G Q + + YI ++ G G L GD LL VN L
Sbjct: 230 LKGPKGLGFSIAGGI---GNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNL 286
Query: 447 HGLTHSEVVNILKQLPDRVRLVCAR-NSIDSGPRPVV-NLASDREGFEARKIISGSLNNL 504
+ H E V LK D V L A+ S+ + AS I S +L
Sbjct: 287 QDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNS--SL 344
Query: 505 TTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGF 564
L +S S T +S + + E + + ++L K GLGF
Sbjct: 345 GYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFT------REPRKIILHKGSTGLGF 398
Query: 565 SILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
+I+ +D G I V ++ GG A+ +GE+ GDR++SVNGV+++NAT +QA ALK
Sbjct: 399 NIVGGED-----GEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALK 453
Query: 625 GAPRGTVKVGIARP 638
A + V RP
Sbjct: 454 RAGQSVTIVAQYRP 467
Score = 67.7 bits (158), Expect = 1e-10
Identities = 35/81 (43%), Positives = 47/81 (58%), Gaps = 2/81 (2%)
Query: 15 LTNDGNGLGFNLVGGRS-TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQV 73
L GLGFN+VGG G+ + ++L GG AD L+ GD +L V VNLR T EQ
Sbjct: 389 LHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQA 448
Query: 74 AAVLRQAGPVVRLLVA-RPAD 93
AA L++AG V ++ RP +
Sbjct: 449 AAALKRAGQSVTIVAQYRPEE 469
Score = 56.8 bits (131), Expect = 2e-07
Identities = 33/91 (36%), Positives = 46/91 (50%), Gaps = 7/91 (7%)
Query: 11 EVVELTNDGNGLGFNLVGGRST-------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSV 63
E + L +GLGF++ GG G+ I ++PGG A D RL D VL+V V
Sbjct: 130 EEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEV 189
Query: 64 NLRGFTSEQVAAVLRQAGPVVRLLVARPADP 94
+ + L++AGPVVRL+V R P
Sbjct: 190 EVSEVVHSRAVEALKEAGPVVRLVVRRRQPP 220
Score = 56.8 bits (131), Expect = 2e-07
Identities = 33/101 (32%), Positives = 59/101 (58%), Gaps = 5/101 (4%)
Query: 181 PTITITVPVELPEIE-IIHVDLNKNVYGLGITVAGYVCEKEELSG---IFVKSIIEGSSA 236
P + + V P E I+ V+L K GLG ++AG + + + G I++ IIEG +A
Sbjct: 208 PVVRLVVRRRQPPPETIMEVNLLKGPKGLGFSIAGGI-GNQHIPGDNSIYITKIIEGGAA 266
Query: 237 EQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHL 277
++ G+++I DR++ V+ +L D + ++V L+NT V+L
Sbjct: 267 QKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYL 307
Score = 54.0 bits (124), Expect = 2e-06
Identities = 32/97 (32%), Positives = 52/97 (53%), Gaps = 2/97 (2%)
Query: 549 KEDIVMLVKADQGLGFSILDYQD-PVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVN 607
K + ++L + + GLGFSI D P P+ I + ++PGG A +G + D V+ VN
Sbjct: 128 KYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVN 187
Query: 608 GVSIQNATLDQAVQALKGAPRGTVKVGIARPLPPQDS 644
V + +AV+ALK A V++ + R PP ++
Sbjct: 188 EVEVSEVVHSRAVEALKEA-GPVVRLVVRRRQPPPET 223
Score = 54.0 bits (124), Expect = 2e-06
Identities = 31/86 (36%), Positives = 43/86 (50%), Gaps = 7/86 (8%)
Query: 13 VELTNDGNGLGFNLVGG-------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L GLGF++ GG + I ++ GG A KD RLQ GD +L V + NL
Sbjct: 227 VNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNL 286
Query: 66 RGFTSEQVAAVLRQAGPVVRLLVARP 91
+ E+ A L+ +V L VA+P
Sbjct: 287 QDVRHEEAVASLKNTSDMVYLKVAKP 312
Score = 53.2 bits (122), Expect = 3e-06
Identities = 29/87 (33%), Positives = 50/87 (57%), Gaps = 2/87 (2%)
Query: 553 VMLVKADQGLGFSILD-YQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSI 611
V L+K +GLGFSI + P I + ++ GG A+K+G + GDR+++VN ++
Sbjct: 227 VNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNL 286
Query: 612 QNATLDQAVQALKGAPRGTVKVGIARP 638
Q+ ++AV +LK V + +A+P
Sbjct: 287 QDVRHEEAVASLKNT-SDMVYLKVAKP 312
Score = 52.8 bits (121), Expect = 4e-06
Identities = 28/80 (35%), Positives = 47/80 (58%), Gaps = 4/80 (5%)
Query: 201 LNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKS 260
L+K GLG + G E+ GIFV I+ G A+ SG+++ DRI+ V+G++L + +
Sbjct: 389 LHKGSTGLGFNIVG----GEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNAT 444
Query: 261 NPQSVEILRNTGISVHLVLE 280
+ Q+ L+ G SV +V +
Sbjct: 445 HEQAAAALKRAGQSVTIVAQ 464
Score = 50.8 bits (116), Expect = 1e-05
Identities = 41/136 (30%), Positives = 59/136 (43%), Gaps = 7/136 (5%)
Query: 372 KKWKEEI-GSDKEILVAEI---KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVG 427
+ W E++ GSD EI + GLG S+ G +D + P +I ++P G
Sbjct: 114 RDWYEQVNGSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPD-DPGIFITKIIPGGAAA 172
Query: 428 LQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASD 487
+ G L D +L VNE + + HS V LK+ VRLV R VNL
Sbjct: 173 MDGRLGVNDCVLRVNEVEVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKG 232
Query: 488 REGFEARKIISGSLNN 503
+G I+G + N
Sbjct: 233 PKGLGFS--IAGGIGN 246
Score = 49.2 bits (112), Expect = 5e-05
Identities = 25/83 (30%), Positives = 47/83 (56%), Gaps = 2/83 (2%)
Query: 201 LNKNVYGLGITVAGYVCEKE--ELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLAD 258
L + GLG ++AG + + GIF+ II G +A G++ +ND ++ V+ + +++
Sbjct: 134 LERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVEVSE 193
Query: 259 KSNPQSVEILRNTGISVHLVLER 281
+ ++VE L+ G V LV+ R
Sbjct: 194 VVHSRAVEALKEAGPVVRLVVRR 216
>BC093866-1|AAH93866.1| 817|Homo sapiens discs, large homolog 3
(neuroendocrine-dlg, Drosophila) protein.
Length = 817
Score = 79.4 bits (187), Expect = 4e-14
Identities = 77/254 (30%), Positives = 113/254 (44%), Gaps = 20/254 (7%)
Query: 389 IKKLEGLGISLEGTVDVEGGQELRPHH--YIRSVLPDGPVGLQGVLNAGDELLEVNEYRL 446
+K +GLG S+ G + G Q + + YI ++ G G L GD LL VN L
Sbjct: 230 LKGPKGLGFSIAGGI---GNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNL 286
Query: 447 HGLTHSEVVNILKQLPDRVRLVCAR-NSIDSGPRPVV-NLASDREGFEARKIISGSLNNL 504
+ H E V LK D V L A+ S+ + AS I S +L
Sbjct: 287 QDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNS--SL 344
Query: 505 TTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGF 564
L +S S T +S + + E + + ++L K GLGF
Sbjct: 345 GYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFT------REPRKIILHKGSTGLGF 398
Query: 565 SILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
+I+ +D G I V ++ GG A+ +GE+ GDR++SVNGV+++NAT +QA ALK
Sbjct: 399 NIVGGED-----GEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALK 453
Query: 625 GAPRGTVKVGIARP 638
A + V RP
Sbjct: 454 RAGQSVTIVAQYRP 467
Score = 67.7 bits (158), Expect = 1e-10
Identities = 35/81 (43%), Positives = 47/81 (58%), Gaps = 2/81 (2%)
Query: 15 LTNDGNGLGFNLVGGRS-TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQV 73
L GLGFN+VGG G+ + ++L GG AD L+ GD +L V VNLR T EQ
Sbjct: 389 LHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQA 448
Query: 74 AAVLRQAGPVVRLLVA-RPAD 93
AA L++AG V ++ RP +
Sbjct: 449 AAALKRAGQSVTIVAQYRPEE 469
Score = 57.2 bits (132), Expect = 2e-07
Identities = 33/91 (36%), Positives = 47/91 (51%), Gaps = 7/91 (7%)
Query: 11 EVVELTNDGNGLGFNLVGGRST-------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSV 63
E + L +GLGF++ GG G+ I ++PGG A D RL D VL+V V
Sbjct: 130 EEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEV 189
Query: 64 NLRGFTSEQVAAVLRQAGPVVRLLVARPADP 94
++ + L++AGPVVRL+V R P
Sbjct: 190 DVSEVVHSRAVEALKEAGPVVRLVVRRRQPP 220
Score = 56.8 bits (131), Expect = 2e-07
Identities = 33/101 (32%), Positives = 59/101 (58%), Gaps = 5/101 (4%)
Query: 181 PTITITVPVELPEIE-IIHVDLNKNVYGLGITVAGYVCEKEELSG---IFVKSIIEGSSA 236
P + + V P E I+ V+L K GLG ++AG + + + G I++ IIEG +A
Sbjct: 208 PVVRLVVRRRQPPPETIMEVNLLKGPKGLGFSIAGGI-GNQHIPGDNSIYITKIIEGGAA 266
Query: 237 EQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHL 277
++ G+++I DR++ V+ +L D + ++V L+NT V+L
Sbjct: 267 QKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYL 307
Score = 54.0 bits (124), Expect = 2e-06
Identities = 32/97 (32%), Positives = 52/97 (53%), Gaps = 2/97 (2%)
Query: 549 KEDIVMLVKADQGLGFSILDYQD-PVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVN 607
K + ++L + + GLGFSI D P P+ I + ++PGG A +G + D V+ VN
Sbjct: 128 KYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVN 187
Query: 608 GVSIQNATLDQAVQALKGAPRGTVKVGIARPLPPQDS 644
V + +AV+ALK A V++ + R PP ++
Sbjct: 188 EVDVSEVVHSRAVEALKEA-GPVVRLVVRRRQPPPET 223
Score = 54.0 bits (124), Expect = 2e-06
Identities = 31/86 (36%), Positives = 43/86 (50%), Gaps = 7/86 (8%)
Query: 13 VELTNDGNGLGFNLVGG-------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L GLGF++ GG + I ++ GG A KD RLQ GD +L V + NL
Sbjct: 227 VNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNL 286
Query: 66 RGFTSEQVAAVLRQAGPVVRLLVARP 91
+ E+ A L+ +V L VA+P
Sbjct: 287 QDVRHEEAVASLKNTSDMVYLKVAKP 312
Score = 53.2 bits (122), Expect = 3e-06
Identities = 29/87 (33%), Positives = 50/87 (57%), Gaps = 2/87 (2%)
Query: 553 VMLVKADQGLGFSILD-YQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSI 611
V L+K +GLGFSI + P I + ++ GG A+K+G + GDR+++VN ++
Sbjct: 227 VNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNL 286
Query: 612 QNATLDQAVQALKGAPRGTVKVGIARP 638
Q+ ++AV +LK V + +A+P
Sbjct: 287 QDVRHEEAVASLKNT-SDMVYLKVAKP 312
Score = 52.8 bits (121), Expect = 4e-06
Identities = 28/80 (35%), Positives = 47/80 (58%), Gaps = 4/80 (5%)
Query: 201 LNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKS 260
L+K GLG + G E+ GIFV I+ G A+ SG+++ DRI+ V+G++L + +
Sbjct: 389 LHKGSTGLGFNIVG----GEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNAT 444
Query: 261 NPQSVEILRNTGISVHLVLE 280
+ Q+ L+ G SV +V +
Sbjct: 445 HEQAAAALKRAGQSVTIVAQ 464
Score = 50.0 bits (114), Expect = 3e-05
Identities = 41/136 (30%), Positives = 59/136 (43%), Gaps = 7/136 (5%)
Query: 372 KKWKEEI-GSDKEILVAEI---KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVG 427
+ W E++ GSD EI + GLG S+ G +D + P +I ++P G
Sbjct: 114 RDWYEQVNGSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPD-DPGIFITKIIPGGAAA 172
Query: 428 LQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASD 487
+ G L D +L VNE + + HS V LK+ VRLV R VNL
Sbjct: 173 MDGRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKG 232
Query: 488 REGFEARKIISGSLNN 503
+G I+G + N
Sbjct: 233 PKGLGFS--IAGGIGN 246
Score = 49.2 bits (112), Expect = 5e-05
Identities = 25/83 (30%), Positives = 47/83 (56%), Gaps = 2/83 (2%)
Query: 201 LNKNVYGLGITVAGYVCEKE--ELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLAD 258
L + GLG ++AG + + GIF+ II G +A G++ +ND ++ V+ + +++
Sbjct: 134 LERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSE 193
Query: 259 KSNPQSVEILRNTGISVHLVLER 281
+ ++VE L+ G V LV+ R
Sbjct: 194 VVHSRAVEALKEAGPVVRLVVRR 216
>BC093864-1|AAH93864.1| 817|Homo sapiens discs, large homolog 3
(neuroendocrine-dlg, Drosophila) protein.
Length = 817
Score = 79.4 bits (187), Expect = 4e-14
Identities = 77/254 (30%), Positives = 113/254 (44%), Gaps = 20/254 (7%)
Query: 389 IKKLEGLGISLEGTVDVEGGQELRPHH--YIRSVLPDGPVGLQGVLNAGDELLEVNEYRL 446
+K +GLG S+ G + G Q + + YI ++ G G L GD LL VN L
Sbjct: 230 LKGPKGLGFSIAGGI---GNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNL 286
Query: 447 HGLTHSEVVNILKQLPDRVRLVCAR-NSIDSGPRPVV-NLASDREGFEARKIISGSLNNL 504
+ H E V LK D V L A+ S+ + AS I S +L
Sbjct: 287 QDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNS--SL 344
Query: 505 TTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGF 564
L +S S T +S + + E + + ++L K GLGF
Sbjct: 345 GYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFT------REPRKIILHKGSTGLGF 398
Query: 565 SILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
+I+ +D G I V ++ GG A+ +GE+ GDR++SVNGV+++NAT +QA ALK
Sbjct: 399 NIVGGED-----GEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALK 453
Query: 625 GAPRGTVKVGIARP 638
A + V RP
Sbjct: 454 RAGQSVTIVAQYRP 467
Score = 67.7 bits (158), Expect = 1e-10
Identities = 35/81 (43%), Positives = 47/81 (58%), Gaps = 2/81 (2%)
Query: 15 LTNDGNGLGFNLVGGRS-TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQV 73
L GLGFN+VGG G+ + ++L GG AD L+ GD +L V VNLR T EQ
Sbjct: 389 LHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQA 448
Query: 74 AAVLRQAGPVVRLLVA-RPAD 93
AA L++AG V ++ RP +
Sbjct: 449 AAALKRAGQSVTIVAQYRPEE 469
Score = 57.2 bits (132), Expect = 2e-07
Identities = 33/91 (36%), Positives = 47/91 (51%), Gaps = 7/91 (7%)
Query: 11 EVVELTNDGNGLGFNLVGGRST-------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSV 63
E + L +GLGF++ GG G+ I ++PGG A D RL D VL+V V
Sbjct: 130 EEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEV 189
Query: 64 NLRGFTSEQVAAVLRQAGPVVRLLVARPADP 94
++ + L++AGPVVRL+V R P
Sbjct: 190 DVSEVVHSRAVEALKEAGPVVRLVVRRRQPP 220
Score = 56.8 bits (131), Expect = 2e-07
Identities = 33/101 (32%), Positives = 59/101 (58%), Gaps = 5/101 (4%)
Query: 181 PTITITVPVELPEIE-IIHVDLNKNVYGLGITVAGYVCEKEELSG---IFVKSIIEGSSA 236
P + + V P E I+ V+L K GLG ++AG + + + G I++ IIEG +A
Sbjct: 208 PVVRLVVRRRQPPPETIMEVNLLKGPKGLGFSIAGGI-GNQHIPGDNSIYITKIIEGGAA 266
Query: 237 EQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHL 277
++ G+++I DR++ V+ +L D + ++V L+NT V+L
Sbjct: 267 QKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYL 307
Score = 54.0 bits (124), Expect = 2e-06
Identities = 32/97 (32%), Positives = 52/97 (53%), Gaps = 2/97 (2%)
Query: 549 KEDIVMLVKADQGLGFSILDYQD-PVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVN 607
K + ++L + + GLGFSI D P P+ I + ++PGG A +G + D V+ VN
Sbjct: 128 KYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVN 187
Query: 608 GVSIQNATLDQAVQALKGAPRGTVKVGIARPLPPQDS 644
V + +AV+ALK A V++ + R PP ++
Sbjct: 188 EVDVSEVVHSRAVEALKEA-GPVVRLVVRRRQPPPET 223
Score = 54.0 bits (124), Expect = 2e-06
Identities = 31/86 (36%), Positives = 43/86 (50%), Gaps = 7/86 (8%)
Query: 13 VELTNDGNGLGFNLVGG-------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L GLGF++ GG + I ++ GG A KD RLQ GD +L V + NL
Sbjct: 227 VNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNL 286
Query: 66 RGFTSEQVAAVLRQAGPVVRLLVARP 91
+ E+ A L+ +V L VA+P
Sbjct: 287 QDVRHEEAVASLKNTSDMVYLKVAKP 312
Score = 53.2 bits (122), Expect = 3e-06
Identities = 29/87 (33%), Positives = 50/87 (57%), Gaps = 2/87 (2%)
Query: 553 VMLVKADQGLGFSILD-YQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSI 611
V L+K +GLGFSI + P I + ++ GG A+K+G + GDR+++VN ++
Sbjct: 227 VNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNL 286
Query: 612 QNATLDQAVQALKGAPRGTVKVGIARP 638
Q+ ++AV +LK V + +A+P
Sbjct: 287 QDVRHEEAVASLKNT-SDMVYLKVAKP 312
Score = 52.8 bits (121), Expect = 4e-06
Identities = 28/80 (35%), Positives = 47/80 (58%), Gaps = 4/80 (5%)
Query: 201 LNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKS 260
L+K GLG + G E+ GIFV I+ G A+ SG+++ DRI+ V+G++L + +
Sbjct: 389 LHKGSTGLGFNIVG----GEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNAT 444
Query: 261 NPQSVEILRNTGISVHLVLE 280
+ Q+ L+ G SV +V +
Sbjct: 445 HEQAAAALKRAGQSVTIVAQ 464
Score = 50.0 bits (114), Expect = 3e-05
Identities = 41/136 (30%), Positives = 59/136 (43%), Gaps = 7/136 (5%)
Query: 372 KKWKEEI-GSDKEILVAEI---KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVG 427
+ W E++ GSD EI + GLG S+ G +D + P +I ++P G
Sbjct: 114 RDWYEQVNGSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPD-DPGIFITKIIPGGAAA 172
Query: 428 LQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASD 487
+ G L D +L VNE + + HS V LK+ VRLV R VNL
Sbjct: 173 MDGRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKG 232
Query: 488 REGFEARKIISGSLNN 503
+G I+G + N
Sbjct: 233 PKGLGFS--IAGGIGN 246
Score = 49.2 bits (112), Expect = 5e-05
Identities = 25/83 (30%), Positives = 47/83 (56%), Gaps = 2/83 (2%)
Query: 201 LNKNVYGLGITVAGYVCEKE--ELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLAD 258
L + GLG ++AG + + GIF+ II G +A G++ +ND ++ V+ + +++
Sbjct: 134 LERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSE 193
Query: 259 KSNPQSVEILRNTGISVHLVLER 281
+ ++VE L+ G V LV+ R
Sbjct: 194 VVHSRAVEALKEAGPVVRLVVRR 216
>AL139398-3|CAI41021.1| 849|Homo sapiens discs, large homolog 3
(neuroendocrine-dlg, Drosophila) protein.
Length = 849
Score = 79.4 bits (187), Expect = 4e-14
Identities = 77/254 (30%), Positives = 113/254 (44%), Gaps = 20/254 (7%)
Query: 389 IKKLEGLGISLEGTVDVEGGQELRPHH--YIRSVLPDGPVGLQGVLNAGDELLEVNEYRL 446
+K +GLG S+ G + G Q + + YI ++ G G L GD LL VN L
Sbjct: 248 LKGPKGLGFSIAGGI---GNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNL 304
Query: 447 HGLTHSEVVNILKQLPDRVRLVCAR-NSIDSGPRPVV-NLASDREGFEARKIISGSLNNL 504
+ H E V LK D V L A+ S+ + AS I S +L
Sbjct: 305 QDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNS--SL 362
Query: 505 TTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGF 564
L +S S T +S + + E + + ++L K GLGF
Sbjct: 363 GYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFT------REPRKIILHKGSTGLGF 416
Query: 565 SILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
+I+ +D G I V ++ GG A+ +GE+ GDR++SVNGV+++NAT +QA ALK
Sbjct: 417 NIVGGED-----GEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALK 471
Query: 625 GAPRGTVKVGIARP 638
A + V RP
Sbjct: 472 RAGQSVTIVAQYRP 485
Score = 67.7 bits (158), Expect = 1e-10
Identities = 35/81 (43%), Positives = 47/81 (58%), Gaps = 2/81 (2%)
Query: 15 LTNDGNGLGFNLVGGRS-TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQV 73
L GLGFN+VGG G+ + ++L GG AD L+ GD +L V VNLR T EQ
Sbjct: 407 LHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQA 466
Query: 74 AAVLRQAGPVVRLLVA-RPAD 93
AA L++AG V ++ RP +
Sbjct: 467 AAALKRAGQSVTIVAQYRPEE 487
Score = 57.2 bits (132), Expect = 2e-07
Identities = 33/91 (36%), Positives = 47/91 (51%), Gaps = 7/91 (7%)
Query: 11 EVVELTNDGNGLGFNLVGGRST-------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSV 63
E + L +GLGF++ GG G+ I ++PGG A D RL D VL+V V
Sbjct: 148 EEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEV 207
Query: 64 NLRGFTSEQVAAVLRQAGPVVRLLVARPADP 94
++ + L++AGPVVRL+V R P
Sbjct: 208 DVSEVVHSRAVEALKEAGPVVRLVVRRRQPP 238
Score = 56.8 bits (131), Expect = 2e-07
Identities = 33/101 (32%), Positives = 59/101 (58%), Gaps = 5/101 (4%)
Query: 181 PTITITVPVELPEIE-IIHVDLNKNVYGLGITVAGYVCEKEELSG---IFVKSIIEGSSA 236
P + + V P E I+ V+L K GLG ++AG + + + G I++ IIEG +A
Sbjct: 226 PVVRLVVRRRQPPPETIMEVNLLKGPKGLGFSIAGGI-GNQHIPGDNSIYITKIIEGGAA 284
Query: 237 EQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHL 277
++ G+++I DR++ V+ +L D + ++V L+NT V+L
Sbjct: 285 QKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYL 325
Score = 54.4 bits (125), Expect = 1e-06
Identities = 38/124 (30%), Positives = 62/124 (50%), Gaps = 6/124 (4%)
Query: 522 ATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQD-PVDPNGTVI 580
A L + E K S S+ G+ ++ ++L + + GLGFSI D P P+ I
Sbjct: 123 APLLVNPETLKHSLSVNGSDGMFKYEE----IVLERGNSGLGFSIAGGIDNPHVPDDPGI 178
Query: 581 VVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPLP 640
+ ++PGG A +G + D V+ VN V + +AV+ALK A V++ + R P
Sbjct: 179 FITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSRAVEALKEA-GPVVRLVVRRRQP 237
Query: 641 PQDS 644
P ++
Sbjct: 238 PPET 241
Score = 54.0 bits (124), Expect = 2e-06
Identities = 31/86 (36%), Positives = 43/86 (50%), Gaps = 7/86 (8%)
Query: 13 VELTNDGNGLGFNLVGG-------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L GLGF++ GG + I ++ GG A KD RLQ GD +L V + NL
Sbjct: 245 VNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNL 304
Query: 66 RGFTSEQVAAVLRQAGPVVRLLVARP 91
+ E+ A L+ +V L VA+P
Sbjct: 305 QDVRHEEAVASLKNTSDMVYLKVAKP 330
Score = 53.2 bits (122), Expect = 3e-06
Identities = 29/87 (33%), Positives = 50/87 (57%), Gaps = 2/87 (2%)
Query: 553 VMLVKADQGLGFSILD-YQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSI 611
V L+K +GLGFSI + P I + ++ GG A+K+G + GDR+++VN ++
Sbjct: 245 VNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNL 304
Query: 612 QNATLDQAVQALKGAPRGTVKVGIARP 638
Q+ ++AV +LK V + +A+P
Sbjct: 305 QDVRHEEAVASLKNT-SDMVYLKVAKP 330
Score = 52.8 bits (121), Expect = 4e-06
Identities = 28/80 (35%), Positives = 47/80 (58%), Gaps = 4/80 (5%)
Query: 201 LNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKS 260
L+K GLG + G E+ GIFV I+ G A+ SG+++ DRI+ V+G++L + +
Sbjct: 407 LHKGSTGLGFNIVG----GEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNAT 462
Query: 261 NPQSVEILRNTGISVHLVLE 280
+ Q+ L+ G SV +V +
Sbjct: 463 HEQAAAALKRAGQSVTIVAQ 482
Score = 49.2 bits (112), Expect = 5e-05
Identities = 25/83 (30%), Positives = 47/83 (56%), Gaps = 2/83 (2%)
Query: 201 LNKNVYGLGITVAGYVCEKE--ELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLAD 258
L + GLG ++AG + + GIF+ II G +A G++ +ND ++ V+ + +++
Sbjct: 152 LERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSE 211
Query: 259 KSNPQSVEILRNTGISVHLVLER 281
+ ++VE L+ G V LV+ R
Sbjct: 212 VVHSRAVEALKEAGPVVRLVVRR 234
Score = 46.8 bits (106), Expect = 2e-04
Identities = 34/110 (30%), Positives = 48/110 (43%), Gaps = 3/110 (2%)
Query: 394 GLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSE 453
GLG S+ G +D + P +I ++P G + G L D +L VNE + + HS
Sbjct: 158 GLGFSIAGGIDNPHVPD-DPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSR 216
Query: 454 VVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNN 503
V LK+ VRLV R VNL +G I+G + N
Sbjct: 217 AVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKGPKGLGFS--IAGGIGN 264
>AL139398-2|CAI41022.1| 817|Homo sapiens discs, large homolog 3
(neuroendocrine-dlg, Drosophila) protein.
Length = 817
Score = 79.4 bits (187), Expect = 4e-14
Identities = 77/254 (30%), Positives = 113/254 (44%), Gaps = 20/254 (7%)
Query: 389 IKKLEGLGISLEGTVDVEGGQELRPHH--YIRSVLPDGPVGLQGVLNAGDELLEVNEYRL 446
+K +GLG S+ G + G Q + + YI ++ G G L GD LL VN L
Sbjct: 230 LKGPKGLGFSIAGGI---GNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNL 286
Query: 447 HGLTHSEVVNILKQLPDRVRLVCAR-NSIDSGPRPVV-NLASDREGFEARKIISGSLNNL 504
+ H E V LK D V L A+ S+ + AS I S +L
Sbjct: 287 QDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNS--SL 344
Query: 505 TTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGF 564
L +S S T +S + + E + + ++L K GLGF
Sbjct: 345 GYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFT------REPRKIILHKGSTGLGF 398
Query: 565 SILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
+I+ +D G I V ++ GG A+ +GE+ GDR++SVNGV+++NAT +QA ALK
Sbjct: 399 NIVGGED-----GEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALK 453
Query: 625 GAPRGTVKVGIARP 638
A + V RP
Sbjct: 454 RAGQSVTIVAQYRP 467
Score = 67.7 bits (158), Expect = 1e-10
Identities = 35/81 (43%), Positives = 47/81 (58%), Gaps = 2/81 (2%)
Query: 15 LTNDGNGLGFNLVGGRS-TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQV 73
L GLGFN+VGG G+ + ++L GG AD L+ GD +L V VNLR T EQ
Sbjct: 389 LHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQA 448
Query: 74 AAVLRQAGPVVRLLVA-RPAD 93
AA L++AG V ++ RP +
Sbjct: 449 AAALKRAGQSVTIVAQYRPEE 469
Score = 57.2 bits (132), Expect = 2e-07
Identities = 33/91 (36%), Positives = 47/91 (51%), Gaps = 7/91 (7%)
Query: 11 EVVELTNDGNGLGFNLVGGRST-------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSV 63
E + L +GLGF++ GG G+ I ++PGG A D RL D VL+V V
Sbjct: 130 EEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEV 189
Query: 64 NLRGFTSEQVAAVLRQAGPVVRLLVARPADP 94
++ + L++AGPVVRL+V R P
Sbjct: 190 DVSEVVHSRAVEALKEAGPVVRLVVRRRQPP 220
Score = 56.8 bits (131), Expect = 2e-07
Identities = 33/101 (32%), Positives = 59/101 (58%), Gaps = 5/101 (4%)
Query: 181 PTITITVPVELPEIE-IIHVDLNKNVYGLGITVAGYVCEKEELSG---IFVKSIIEGSSA 236
P + + V P E I+ V+L K GLG ++AG + + + G I++ IIEG +A
Sbjct: 208 PVVRLVVRRRQPPPETIMEVNLLKGPKGLGFSIAGGI-GNQHIPGDNSIYITKIIEGGAA 266
Query: 237 EQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHL 277
++ G+++I DR++ V+ +L D + ++V L+NT V+L
Sbjct: 267 QKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYL 307
Score = 54.0 bits (124), Expect = 2e-06
Identities = 32/97 (32%), Positives = 52/97 (53%), Gaps = 2/97 (2%)
Query: 549 KEDIVMLVKADQGLGFSILDYQD-PVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVN 607
K + ++L + + GLGFSI D P P+ I + ++PGG A +G + D V+ VN
Sbjct: 128 KYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVN 187
Query: 608 GVSIQNATLDQAVQALKGAPRGTVKVGIARPLPPQDS 644
V + +AV+ALK A V++ + R PP ++
Sbjct: 188 EVDVSEVVHSRAVEALKEA-GPVVRLVVRRRQPPPET 223
Score = 54.0 bits (124), Expect = 2e-06
Identities = 31/86 (36%), Positives = 43/86 (50%), Gaps = 7/86 (8%)
Query: 13 VELTNDGNGLGFNLVGG-------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L GLGF++ GG + I ++ GG A KD RLQ GD +L V + NL
Sbjct: 227 VNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNL 286
Query: 66 RGFTSEQVAAVLRQAGPVVRLLVARP 91
+ E+ A L+ +V L VA+P
Sbjct: 287 QDVRHEEAVASLKNTSDMVYLKVAKP 312
Score = 53.2 bits (122), Expect = 3e-06
Identities = 29/87 (33%), Positives = 50/87 (57%), Gaps = 2/87 (2%)
Query: 553 VMLVKADQGLGFSILD-YQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSI 611
V L+K +GLGFSI + P I + ++ GG A+K+G + GDR+++VN ++
Sbjct: 227 VNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNL 286
Query: 612 QNATLDQAVQALKGAPRGTVKVGIARP 638
Q+ ++AV +LK V + +A+P
Sbjct: 287 QDVRHEEAVASLKNT-SDMVYLKVAKP 312
Score = 52.8 bits (121), Expect = 4e-06
Identities = 28/80 (35%), Positives = 47/80 (58%), Gaps = 4/80 (5%)
Query: 201 LNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKS 260
L+K GLG + G E+ GIFV I+ G A+ SG+++ DRI+ V+G++L + +
Sbjct: 389 LHKGSTGLGFNIVG----GEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNAT 444
Query: 261 NPQSVEILRNTGISVHLVLE 280
+ Q+ L+ G SV +V +
Sbjct: 445 HEQAAAALKRAGQSVTIVAQ 464
Score = 50.0 bits (114), Expect = 3e-05
Identities = 41/136 (30%), Positives = 59/136 (43%), Gaps = 7/136 (5%)
Query: 372 KKWKEEI-GSDKEILVAEI---KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVG 427
+ W E++ GSD EI + GLG S+ G +D + P +I ++P G
Sbjct: 114 RDWYEQVNGSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPD-DPGIFITKIIPGGAAA 172
Query: 428 LQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASD 487
+ G L D +L VNE + + HS V LK+ VRLV R VNL
Sbjct: 173 MDGRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKG 232
Query: 488 REGFEARKIISGSLNN 503
+G I+G + N
Sbjct: 233 PKGLGFS--IAGGIGN 246
Score = 49.2 bits (112), Expect = 5e-05
Identities = 25/83 (30%), Positives = 47/83 (56%), Gaps = 2/83 (2%)
Query: 201 LNKNVYGLGITVAGYVCEKE--ELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLAD 258
L + GLG ++AG + + GIF+ II G +A G++ +ND ++ V+ + +++
Sbjct: 134 LERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSE 193
Query: 259 KSNPQSVEILRNTGISVHLVLER 281
+ ++VE L+ G V LV+ R
Sbjct: 194 VVHSRAVEALKEAGPVVRLVVRR 216
>AB209328-1|BAD92565.1| 917|Homo sapiens synapse-associated protein
102 variant protein.
Length = 917
Score = 79.4 bits (187), Expect = 4e-14
Identities = 77/254 (30%), Positives = 113/254 (44%), Gaps = 20/254 (7%)
Query: 389 IKKLEGLGISLEGTVDVEGGQELRPHH--YIRSVLPDGPVGLQGVLNAGDELLEVNEYRL 446
+K +GLG S+ G + G Q + + YI ++ G G L GD LL VN L
Sbjct: 330 LKGPKGLGFSIAGGI---GNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNL 386
Query: 447 HGLTHSEVVNILKQLPDRVRLVCAR-NSIDSGPRPVV-NLASDREGFEARKIISGSLNNL 504
+ H E V LK D V L A+ S+ + AS I S +L
Sbjct: 387 QDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNS--SL 444
Query: 505 TTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGF 564
L +S S T +S + + E + + ++L K GLGF
Sbjct: 445 GYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFT------REPRKIILHKGSTGLGF 498
Query: 565 SILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
+I+ +D G I V ++ GG A+ +GE+ GDR++SVNGV+++NAT +QA ALK
Sbjct: 499 NIVGGED-----GEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALK 553
Query: 625 GAPRGTVKVGIARP 638
A + V RP
Sbjct: 554 RAGQSVTIVAQYRP 567
Score = 67.7 bits (158), Expect = 1e-10
Identities = 35/81 (43%), Positives = 47/81 (58%), Gaps = 2/81 (2%)
Query: 15 LTNDGNGLGFNLVGGRS-TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQV 73
L GLGFN+VGG G+ + ++L GG AD L+ GD +L V VNLR T EQ
Sbjct: 489 LHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQA 548
Query: 74 AAVLRQAGPVVRLLVA-RPAD 93
AA L++AG V ++ RP +
Sbjct: 549 AAALKRAGQSVTIVAQYRPEE 569
Score = 57.2 bits (132), Expect = 2e-07
Identities = 33/91 (36%), Positives = 47/91 (51%), Gaps = 7/91 (7%)
Query: 11 EVVELTNDGNGLGFNLVGGRST-------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSV 63
E + L +GLGF++ GG G+ I ++PGG A D RL D VL+V V
Sbjct: 230 EEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEV 289
Query: 64 NLRGFTSEQVAAVLRQAGPVVRLLVARPADP 94
++ + L++AGPVVRL+V R P
Sbjct: 290 DVSEVVHSRAVEALKEAGPVVRLVVRRRQPP 320
Score = 56.8 bits (131), Expect = 2e-07
Identities = 33/101 (32%), Positives = 59/101 (58%), Gaps = 5/101 (4%)
Query: 181 PTITITVPVELPEIE-IIHVDLNKNVYGLGITVAGYVCEKEELSG---IFVKSIIEGSSA 236
P + + V P E I+ V+L K GLG ++AG + + + G I++ IIEG +A
Sbjct: 308 PVVRLVVRRRQPPPETIMEVNLLKGPKGLGFSIAGGI-GNQHIPGDNSIYITKIIEGGAA 366
Query: 237 EQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHL 277
++ G+++I DR++ V+ +L D + ++V L+NT V+L
Sbjct: 367 QKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYL 407
Score = 54.0 bits (124), Expect = 2e-06
Identities = 32/97 (32%), Positives = 52/97 (53%), Gaps = 2/97 (2%)
Query: 549 KEDIVMLVKADQGLGFSILDYQD-PVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVN 607
K + ++L + + GLGFSI D P P+ I + ++PGG A +G + D V+ VN
Sbjct: 228 KYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVN 287
Query: 608 GVSIQNATLDQAVQALKGAPRGTVKVGIARPLPPQDS 644
V + +AV+ALK A V++ + R PP ++
Sbjct: 288 EVDVSEVVHSRAVEALKEA-GPVVRLVVRRRQPPPET 323
Score = 54.0 bits (124), Expect = 2e-06
Identities = 31/86 (36%), Positives = 43/86 (50%), Gaps = 7/86 (8%)
Query: 13 VELTNDGNGLGFNLVGG-------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L GLGF++ GG + I ++ GG A KD RLQ GD +L V + NL
Sbjct: 327 VNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNL 386
Query: 66 RGFTSEQVAAVLRQAGPVVRLLVARP 91
+ E+ A L+ +V L VA+P
Sbjct: 387 QDVRHEEAVASLKNTSDMVYLKVAKP 412
Score = 53.2 bits (122), Expect = 3e-06
Identities = 29/87 (33%), Positives = 50/87 (57%), Gaps = 2/87 (2%)
Query: 553 VMLVKADQGLGFSILD-YQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSI 611
V L+K +GLGFSI + P I + ++ GG A+K+G + GDR+++VN ++
Sbjct: 327 VNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNL 386
Query: 612 QNATLDQAVQALKGAPRGTVKVGIARP 638
Q+ ++AV +LK V + +A+P
Sbjct: 387 QDVRHEEAVASLKNT-SDMVYLKVAKP 412
Score = 52.8 bits (121), Expect = 4e-06
Identities = 28/80 (35%), Positives = 47/80 (58%), Gaps = 4/80 (5%)
Query: 201 LNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKS 260
L+K GLG + G E+ GIFV I+ G A+ SG+++ DRI+ V+G++L + +
Sbjct: 489 LHKGSTGLGFNIVG----GEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNAT 544
Query: 261 NPQSVEILRNTGISVHLVLE 280
+ Q+ L+ G SV +V +
Sbjct: 545 HEQAAAALKRAGQSVTIVAQ 564
Score = 50.0 bits (114), Expect = 3e-05
Identities = 41/136 (30%), Positives = 59/136 (43%), Gaps = 7/136 (5%)
Query: 372 KKWKEEI-GSDKEILVAEI---KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVG 427
+ W E++ GSD EI + GLG S+ G +D + P +I ++P G
Sbjct: 214 RDWYEQVNGSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPD-DPGIFITKIIPGGAAA 272
Query: 428 LQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASD 487
+ G L D +L VNE + + HS V LK+ VRLV R VNL
Sbjct: 273 MDGRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKG 332
Query: 488 REGFEARKIISGSLNN 503
+G I+G + N
Sbjct: 333 PKGLGFS--IAGGIGN 346
Score = 49.2 bits (112), Expect = 5e-05
Identities = 25/83 (30%), Positives = 47/83 (56%), Gaps = 2/83 (2%)
Query: 201 LNKNVYGLGITVAGYVCEKE--ELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLAD 258
L + GLG ++AG + + GIF+ II G +A G++ +ND ++ V+ + +++
Sbjct: 234 LERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSE 293
Query: 259 KSNPQSVEILRNTGISVHLVLER 281
+ ++VE L+ G V LV+ R
Sbjct: 294 VVHSRAVEALKEAGPVVRLVVRR 316
>X80289-1|CAA56563.1| 2466|Homo sapiens protein-tyrosine-phosphatase
protein.
Length = 2466
Score = 77.4 bits (182), Expect = 1e-13
Identities = 41/97 (42%), Positives = 59/97 (60%)
Query: 195 EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGI 254
+I V+L KN LGI+V G V GI+VK++I +AE G+I DR++ V+G+
Sbjct: 1346 DIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGV 1405
Query: 255 SLADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHL 291
SL ++ Q+VE LRNTG VHL+LE+ EH+
Sbjct: 1406 SLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHV 1442
Score = 68.5 bits (160), Expect = 7e-11
Identities = 36/94 (38%), Positives = 50/94 (53%), Gaps = 5/94 (5%)
Query: 13 VELTNDGNGLGFNLVGGRST-----GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
VEL + N LG ++ GG +T G+ +K V+P G A+ D R+ GD VL V V+L G
Sbjct: 1350 VELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEG 1409
Query: 68 FTSEQVAAVLRQAGPVVRLLVARPADPATALRAP 101
T +Q LR G VV LL+ + P + P
Sbjct: 1410 ATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVP 1443
Score = 58.8 bits (136), Expect = 6e-08
Identities = 35/122 (28%), Positives = 57/122 (46%), Gaps = 3/122 (2%)
Query: 372 KKWKEEIGSDKEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGV 431
K+W ++EI + +KK G+ + + E L +I SV P GP G
Sbjct: 1060 KRWSIVSSPEREITLVNLKKDAKYGLGFQ-IIGGEKMGRLDLGIFISSVAPGGPADFHGC 1118
Query: 432 LNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCA--RNSIDSGPRPVVNLASDRE 489
L GD L+ VN L G++H + IL+ P+ V LV + + I P V+L ++ +
Sbjct: 1119 LKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMK 1178
Query: 490 GF 491
+
Sbjct: 1179 NY 1180
Score = 57.6 bits (133), Expect = 1e-07
Identities = 31/72 (43%), Positives = 45/72 (62%), Gaps = 1/72 (1%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
V L K D LG S+ + +G I V++++P G AE +G I GDRV++VNGVS++
Sbjct: 1350 VELAKNDNSLGISVTGGVNTSVRHGG-IYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLE 1408
Query: 613 NATLDQAVQALK 624
AT QAV+ L+
Sbjct: 1409 GATHKQAVETLR 1420
Score = 57.6 bits (133), Expect = 1e-07
Identities = 61/242 (25%), Positives = 100/242 (41%), Gaps = 35/242 (14%)
Query: 403 VDVEGGQELRPHH---YIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILK 459
+ V GG H Y+++V+P G G ++ GD +L VN L G TH + V L+
Sbjct: 1361 ISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLR 1420
Query: 460 QLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTS 519
V L+ ++ G P + + + +S K + T +
Sbjct: 1421 NTGQVVHLL-----LEKGQSPT---SKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDY 1472
Query: 520 STATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTV 579
S T N E S SGL S+ED ++ P N ++
Sbjct: 1473 SFVTEENTFEVKLFKNS----SGLGFSFSREDNLI-----------------PEQINASI 1511
Query: 580 IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKG-APRGTVKVGIARP 638
+ V+ L G A ++G+I GD ++ VNG S++ + + + AL+G AP V + + RP
Sbjct: 1512 VRVKKLFAGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPE--VFLLLCRP 1569
Query: 639 LP 640
P
Sbjct: 1570 PP 1571
Score = 56.4 bits (130), Expect = 3e-07
Identities = 35/94 (37%), Positives = 51/94 (54%), Gaps = 1/94 (1%)
Query: 189 VELPEIEIIHVDLNKNV-YGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDR 247
V PE EI V+L K+ YGLG + G GIF+ S+ G A+ G +K DR
Sbjct: 1065 VSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADFHGCLKPGDR 1124
Query: 248 IIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
+I V+ +SL S+ ++EIL+N V LV+ +
Sbjct: 1125 LISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQ 1158
Score = 54.8 bits (126), Expect = 9e-07
Identities = 31/98 (31%), Positives = 52/98 (53%), Gaps = 6/98 (6%)
Query: 2 VLSTEWAQVEVVELTNDGN-GLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGD 55
++S+ ++ +V L D GLGF ++GG G + I V PGG AD L+ GD
Sbjct: 1064 IVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADFHGCLKPGD 1123
Query: 56 HVLQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVARPAD 93
++ V SV+L G + +L+ A V L++++P +
Sbjct: 1124 RLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKE 1161
Score = 51.2 bits (117), Expect = 1e-05
Identities = 29/81 (35%), Positives = 47/81 (58%), Gaps = 2/81 (2%)
Query: 558 ADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLD 617
A GLGF I+ + + I + S+ PGG A+ +G + PGDR++SVN VS++ +
Sbjct: 1081 AKYGLGFQIIG-GEKMGRLDLGIFISSVAPGGPADFHGCLKPGDRLISVNSVSLEGVSHH 1139
Query: 618 QAVQALKGAPRGTVKVGIARP 638
A++ L+ AP V I++P
Sbjct: 1140 AAIEILQNAPEDVTLV-ISQP 1159
Score = 48.0 bits (109), Expect = 1e-04
Identities = 32/92 (34%), Positives = 46/92 (50%), Gaps = 3/92 (3%)
Query: 193 EIEIIHVDLNKNVYGLGITVA---GYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRII 249
E V L KN GLG + + + E+ S + VK + G A +SGKI + D I+
Sbjct: 1477 EENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFAGQPAAESGKIDVGDVIL 1536
Query: 250 EVDGISLADKSNPQSVEILRNTGISVHLVLER 281
+V+G SL S + + LR T V L+L R
Sbjct: 1537 KVNGASLKGLSQQEVISALRGTAPEVFLLLCR 1568
Score = 47.6 bits (108), Expect = 1e-04
Identities = 42/144 (29%), Positives = 72/144 (50%), Gaps = 15/144 (10%)
Query: 328 EPEPESNTTIDSSVLEVGDLQEPTQEELDQRFDEILAVDKEDIVKKWKEEIGSDKEILVA 387
+P+ ES ++ + + EPT++E L D E+ ++ ++ E+ E+L+
Sbjct: 1720 QPQSESASSSSMDKYHIHHISEPTRQENWTP----LKNDLENHLEDFELEV----ELLIT 1771
Query: 388 EIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLH 447
IK + SL TV +G Q + Y+ V+ D P G L GD L++VN+ +
Sbjct: 1772 LIKSEKA---SLGFTV-TKGNQRIGC--YVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVT 1824
Query: 448 GLTHSEVVNILKQLPDRVRLVCAR 471
+TH++ VN+L+ VRLV R
Sbjct: 1825 NMTHTDAVNLLRAASKTVRLVIGR 1848
Score = 42.3 bits (95), Expect = 0.005
Identities = 32/104 (30%), Positives = 54/104 (51%), Gaps = 12/104 (11%)
Query: 13 VELTNDGNGLGF------NLVGGRSTGVVI--KYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V+L + +GLGF NL+ + ++ K + G A + ++ GD +L+V +
Sbjct: 1483 VKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFAGQPAAESGKIDVGDVILKVNGAS 1542
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALV 108
L+G + ++V + LR P V LL+ RP P L P+ TAL+
Sbjct: 1543 LKGLSQQEVISALRGTAPEVFLLLCRP--PPGVL--PEIDTALL 1582
Score = 41.5 bits (93), Expect = 0.009
Identities = 26/99 (26%), Positives = 50/99 (50%), Gaps = 5/99 (5%)
Query: 193 EIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVD 252
E+E++ + LG TV + + G +V +I+ A+ G++K DR+I+V+
Sbjct: 1765 EVELLITLIKSEKASLGFTVT----KGNQRIGCYVHDVIQ-DPAKSDGRLKPGDRLIKVN 1819
Query: 253 GISLADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHL 291
+ + ++ +V +LR +V LV+ R L P+ L
Sbjct: 1820 DTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELPRIPML 1858
Score = 37.9 bits (84), Expect = 0.11
Identities = 19/49 (38%), Positives = 29/49 (59%), Gaps = 1/49 (2%)
Query: 591 AEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPL 639
A+ +G + PGDR++ VN + N T AV L+ A + TV++ I R L
Sbjct: 1803 AKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASK-TVRLVIGRVL 1850
Score = 35.5 bits (78), Expect = 0.60
Identities = 29/96 (30%), Positives = 43/96 (44%), Gaps = 4/96 (4%)
Query: 551 DIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVS 610
DI + ++ LGFS+ D + V+ + + P VA G + D + VNGVS
Sbjct: 1864 DITLTCNKEE-LGFSLCGGHDSLYQ---VVYISDINPRSVAAIEGNLQLLDVIHYVNGVS 1919
Query: 611 IQNATLDQAVQALKGAPRGTVKVGIARPLPPQDSSK 646
Q TL++ +AL + V LP SSK
Sbjct: 1920 TQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSK 1955
Score = 35.1 bits (77), Expect = 0.79
Identities = 21/70 (30%), Positives = 34/70 (48%), Gaps = 2/70 (2%)
Query: 22 LGFNLV-GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAVLRQA 80
LGF + G + G + V+ A D RL+ GD +++V ++ T +LR A
Sbjct: 1780 LGFTVTKGNQRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAA 1838
Query: 81 GPVVRLLVAR 90
VRL++ R
Sbjct: 1839 SKTVRLVIGR 1848
Score = 34.3 bits (75), Expect = 1.4
Identities = 29/99 (29%), Positives = 46/99 (46%), Gaps = 9/99 (9%)
Query: 13 VELTNDGNGLGFNLVGGRSTGVVIKYVL---PGGVADKDRRLQSGDHVLQVGSVNLRGFT 69
+ LT + LGF+L GG + + Y+ P VA + LQ D + V V+ +G T
Sbjct: 1865 ITLTCNKEELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMT 1924
Query: 70 SEQVAAVLRQAGPVVRLLVAR------PADPATALRAPQ 102
E+V L + P + L R P+ +A+ AP+
Sbjct: 1925 LEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPK 1963
Score = 33.5 bits (73), Expect = 2.4
Identities = 22/82 (26%), Positives = 36/82 (43%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K GLG S ++ Q ++ + P G ++ GD +L+VN L GL
Sbjct: 1487 KNSSGLGFSFSREDNLIPEQINASIVRVKKLFAGQPAAESGKIDVGDVILKVNGASLKGL 1546
Query: 450 THSEVVNILKQLPDRVRLVCAR 471
+ EV++ L+ V L+ R
Sbjct: 1547 SQQEVISALRGTAPEVFLLLCR 1568
>X79676-1|CAA56124.1| 1267|Homo sapiens tyrosine phosphatase
protein.
Length = 1267
Score = 77.4 bits (182), Expect = 1e-13
Identities = 41/97 (42%), Positives = 59/97 (60%)
Query: 195 EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGI 254
+I V+L KN LGI+V G V GI+VK++I +AE G+I DR++ V+G+
Sbjct: 149 DIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGV 208
Query: 255 SLADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHL 291
SL ++ Q+VE LRNTG VHL+LE+ EH+
Sbjct: 209 SLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHV 245
Score = 68.5 bits (160), Expect = 7e-11
Identities = 36/94 (38%), Positives = 50/94 (53%), Gaps = 5/94 (5%)
Query: 13 VELTNDGNGLGFNLVGGRST-----GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
VEL + N LG ++ GG +T G+ +K V+P G A+ D R+ GD VL V V+L G
Sbjct: 153 VELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEG 212
Query: 68 FTSEQVAAVLRQAGPVVRLLVARPADPATALRAP 101
T +Q LR G VV LL+ + P + P
Sbjct: 213 ATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVP 246
Score = 60.9 bits (141), Expect = 1e-08
Identities = 62/242 (25%), Positives = 101/242 (41%), Gaps = 35/242 (14%)
Query: 403 VDVEGGQELRPHH---YIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILK 459
+ V GG H Y+++V+P G G ++ GD +L VN L G TH + V L+
Sbjct: 164 ISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLR 223
Query: 460 QLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTS 519
V L+ ++ G P + + + +S K + T +
Sbjct: 224 NTGQVVHLL-----LEKGQSPT---SKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDY 275
Query: 520 STATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTV 579
S T N E S SGL S+ED ++ P N ++
Sbjct: 276 SFVTEENTFEVKLFKNS----SGLGFSFSREDNLI-----------------PEQINASI 314
Query: 580 IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKG-APRGTVKVGIARP 638
+ V+ L PG A ++G+I GD ++ VNG S++ + + + AL+G AP V + + RP
Sbjct: 315 VRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPE--VFLLLCRP 372
Query: 639 LP 640
P
Sbjct: 373 PP 374
Score = 57.6 bits (133), Expect = 1e-07
Identities = 31/72 (43%), Positives = 45/72 (62%), Gaps = 1/72 (1%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
V L K D LG S+ + +G I V++++P G AE +G I GDRV++VNGVS++
Sbjct: 153 VELAKNDNSLGISVTGGVNTSVRHGG-IYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLE 211
Query: 613 NATLDQAVQALK 624
AT QAV+ L+
Sbjct: 212 GATHKQAVETLR 223
Score = 48.0 bits (109), Expect = 1e-04
Identities = 32/92 (34%), Positives = 46/92 (50%), Gaps = 3/92 (3%)
Query: 193 EIEIIHVDLNKNVYGLGITVA---GYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRII 249
E V L KN GLG + + + E+ S + VK + G A +SGKI + D I+
Sbjct: 280 EENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVIL 339
Query: 250 EVDGISLADKSNPQSVEILRNTGISVHLVLER 281
+V+G SL S + + LR T V L+L R
Sbjct: 340 KVNGASLKGLSQQEVISALRGTAPEVFLLLCR 371
Score = 45.6 bits (103), Expect = 6e-04
Identities = 33/104 (31%), Positives = 55/104 (52%), Gaps = 12/104 (11%)
Query: 13 VELTNDGNGLGF------NLVGGRSTGVVI--KYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V+L + +GLGF NL+ + ++ K + PG A + ++ GD +L+V +
Sbjct: 286 VKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGAS 345
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALV 108
L+G + ++V + LR P V LL+ RP P L P+ TAL+
Sbjct: 346 LKGLSQQEVISALRGTAPEVFLLLCRP--PPGVL--PEIDTALL 385
Score = 45.6 bits (103), Expect = 6e-04
Identities = 43/144 (29%), Positives = 73/144 (50%), Gaps = 16/144 (11%)
Query: 328 EPEPESNTTIDSSVLEVGDLQEPTQEELDQRFDEILAVDKEDIVKKWKEEIGSDKEILVA 387
+P+ ES ++ + + EPT++E L D E+ ++ ++ E+ E+L+
Sbjct: 523 QPQSESASSSSMDKYHIHHISEPTRQENWTP----LKNDLENHLEDFELEV----ELLIT 574
Query: 388 EIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLH 447
IK +G SL TV +G Q + Y+ V+ D P G L GD L++VN+ +
Sbjct: 575 LIKSEKG---SLGFTV-TKGNQRIGC--YVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVT 627
Query: 448 GLTHSEVVNILKQLPDRVRLVCAR 471
+TH++ VN+L+ VRLV R
Sbjct: 628 NMTHTDAVNLLRG-SKTVRLVIGR 650
Score = 39.1 bits (87), Expect = 0.049
Identities = 25/92 (27%), Positives = 46/92 (50%), Gaps = 7/92 (7%)
Query: 550 EDIVMLVKADQG-LGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNG 608
E ++ L+K+++G LGF++ + V ++ A+ +G + PGDR++ VN
Sbjct: 570 ELLITLIKSEKGSLGFTVTKGNQRIG-----CYVHDVIQDP-AKSDGRLKPGDRLIKVND 623
Query: 609 VSIQNATLDQAVQALKGAPRGTVKVGIARPLP 640
+ N T AV L+G+ + +G LP
Sbjct: 624 TDVTNMTHTDAVNLLRGSKTVRLVIGRVLELP 655
Score = 38.3 bits (85), Expect = 0.085
Identities = 26/99 (26%), Positives = 51/99 (51%), Gaps = 6/99 (6%)
Query: 193 EIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVD 252
E+E++ + LG TV + + G +V +I+ A+ G++K DR+I+V+
Sbjct: 568 EVELLITLIKSEKGSLGFTVT----KGNQRIGCYVHDVIQ-DPAKSDGRLKPGDRLIKVN 622
Query: 253 GISLADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHL 291
+ + ++ +V +LR + +V LV+ R L P+ L
Sbjct: 623 DTDVTNMTHTDAVNLLRGSK-TVRLVIGRVLELPRIPML 660
Score = 36.7 bits (81), Expect = 0.26
Identities = 23/82 (28%), Positives = 37/82 (45%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K GLG S ++ Q ++ + P P G ++ GD +L+VN L GL
Sbjct: 290 KNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGL 349
Query: 450 THSEVVNILKQLPDRVRLVCAR 471
+ EV++ L+ V L+ R
Sbjct: 350 SQQEVISALRGTAPEVFLLLCR 371
Score = 35.5 bits (78), Expect = 0.60
Identities = 29/96 (30%), Positives = 43/96 (44%), Gaps = 4/96 (4%)
Query: 551 DIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVS 610
DI + ++ LGFS+ D + V+ + + P VA G + D + VNGVS
Sbjct: 666 DITLTCNKEE-LGFSLCGGHDSLYQ---VVYISDINPRSVAAIEGNLQLLDVIHYVNGVS 721
Query: 611 IQNATLDQAVQALKGAPRGTVKVGIARPLPPQDSSK 646
Q TL++ +AL + V LP SSK
Sbjct: 722 TQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSK 757
Score = 34.3 bits (75), Expect = 1.4
Identities = 29/99 (29%), Positives = 46/99 (46%), Gaps = 9/99 (9%)
Query: 13 VELTNDGNGLGFNLVGGRSTGVVIKYVL---PGGVADKDRRLQSGDHVLQVGSVNLRGFT 69
+ LT + LGF+L GG + + Y+ P VA + LQ D + V V+ +G T
Sbjct: 667 ITLTCNKEELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMT 726
Query: 70 SEQVAAVLRQAGPVVRLLVAR------PADPATALRAPQ 102
E+V L + P + L R P+ +A+ AP+
Sbjct: 727 LEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPK 765
>D21211-1|BAA04752.1| 2294|Homo sapiens protein tyrosine phosphatase
type 3 protein.
Length = 2294
Score = 77.4 bits (182), Expect = 1e-13
Identities = 41/97 (42%), Positives = 59/97 (60%)
Query: 195 EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGI 254
+I V+L KN LGI+V G V GI+VK++I +AE G+I DR++ V+G+
Sbjct: 1174 DIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGV 1233
Query: 255 SLADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHL 291
SL ++ Q+VE LRNTG VHL+LE+ EH+
Sbjct: 1234 SLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHV 1270
Score = 68.5 bits (160), Expect = 7e-11
Identities = 36/94 (38%), Positives = 50/94 (53%), Gaps = 5/94 (5%)
Query: 13 VELTNDGNGLGFNLVGGRST-----GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
VEL + N LG ++ GG +T G+ +K V+P G A+ D R+ GD VL V V+L G
Sbjct: 1178 VELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEG 1237
Query: 68 FTSEQVAAVLRQAGPVVRLLVARPADPATALRAP 101
T +Q LR G VV LL+ + P + P
Sbjct: 1238 ATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVP 1271
Score = 64.5 bits (150), Expect = 1e-09
Identities = 44/160 (27%), Positives = 73/160 (45%), Gaps = 3/160 (1%)
Query: 334 NTTIDSSVLEVGDLQEPTQEELDQRFDEILAVDKEDIVKKWKEEIGSDKEILVAEIKKLE 393
N+ I +L + Q Q ++ R A D + + K+W ++EI + +KK
Sbjct: 850 NSKICQYLLHLCSYQHKFQLQMRARQSNQDAQDIDVLHKRWSIVSSPEREITLVNLKKDA 909
Query: 394 GLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSE 453
G+ + + E L +I SV P GP L G L GD L+ VN L G++H
Sbjct: 910 KYGLGFQ-IIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHA 968
Query: 454 VVNILKQLPDRVRLVCA--RNSIDSGPRPVVNLASDREGF 491
+ IL+ P+ V LV + + I P V+L ++ + +
Sbjct: 969 AIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNY 1008
Score = 60.9 bits (141), Expect = 1e-08
Identities = 62/242 (25%), Positives = 101/242 (41%), Gaps = 35/242 (14%)
Query: 403 VDVEGGQELRPHH---YIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILK 459
+ V GG H Y+++V+P G G ++ GD +L VN L G TH + V L+
Sbjct: 1189 ISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLR 1248
Query: 460 QLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTS 519
V L+ ++ G P + + + +S K + T +
Sbjct: 1249 NTGQVVHLL-----LEKGQSPT---SKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDY 1300
Query: 520 STATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTV 579
S T N E S SGL S+ED ++ P N ++
Sbjct: 1301 SFVTEENTFEVKLFKNS----SGLGFSFSREDNLI-----------------PEQINASI 1339
Query: 580 IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKG-APRGTVKVGIARP 638
+ V+ L PG A ++G+I GD ++ VNG S++ + + + AL+G AP V + + RP
Sbjct: 1340 VRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPE--VFLLLCRP 1397
Query: 639 LP 640
P
Sbjct: 1398 PP 1399
Score = 58.0 bits (134), Expect = 1e-07
Identities = 32/98 (32%), Positives = 53/98 (54%), Gaps = 6/98 (6%)
Query: 2 VLSTEWAQVEVVELTNDGN-GLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGD 55
++S+ ++ +V L D GLGF ++GG G + I V PGG AD D L+ GD
Sbjct: 892 IVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGD 951
Query: 56 HVLQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVARPAD 93
++ V SV+L G + +L+ A V L++++P +
Sbjct: 952 RLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKE 989
Score = 57.6 bits (133), Expect = 1e-07
Identities = 31/72 (43%), Positives = 45/72 (62%), Gaps = 1/72 (1%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
V L K D LG S+ + +G I V++++P G AE +G I GDRV++VNGVS++
Sbjct: 1178 VELAKNDNSLGISVTGGVNTSVRHGG-IYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLE 1236
Query: 613 NATLDQAVQALK 624
AT QAV+ L+
Sbjct: 1237 GATHKQAVETLR 1248
Score = 57.2 bits (132), Expect = 2e-07
Identities = 35/94 (37%), Positives = 51/94 (54%), Gaps = 1/94 (1%)
Query: 189 VELPEIEIIHVDLNKNV-YGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDR 247
V PE EI V+L K+ YGLG + G GIF+ S+ G A+ G +K DR
Sbjct: 893 VSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDR 952
Query: 248 IIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
+I V+ +SL S+ ++EIL+N V LV+ +
Sbjct: 953 LISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQ 986
Score = 51.6 bits (118), Expect = 9e-06
Identities = 29/81 (35%), Positives = 47/81 (58%), Gaps = 2/81 (2%)
Query: 558 ADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLD 617
A GLGF I+ + + I + S+ PGG A+ +G + PGDR++SVN VS++ +
Sbjct: 909 AKYGLGFQIIG-GEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHH 967
Query: 618 QAVQALKGAPRGTVKVGIARP 638
A++ L+ AP V I++P
Sbjct: 968 AAIEILQNAPEDVTLV-ISQP 987
Score = 50.0 bits (114), Expect = 3e-05
Identities = 43/144 (29%), Positives = 73/144 (50%), Gaps = 15/144 (10%)
Query: 328 EPEPESNTTIDSSVLEVGDLQEPTQEELDQRFDEILAVDKEDIVKKWKEEIGSDKEILVA 387
+P+ ES ++ + + EPT++E L D E+ ++ ++ E+ E+L+
Sbjct: 1548 QPQSESASSSSMDKYHIHHISEPTRQENWTP----LKNDLENHLEDFELEV----ELLIT 1599
Query: 388 EIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLH 447
IK +G SL TV +G Q + Y+ V+ D P G L GD L++VN+ +
Sbjct: 1600 LIKSEKG---SLGFTV-TKGNQRIGC--YVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVT 1652
Query: 448 GLTHSEVVNILKQLPDRVRLVCAR 471
+TH++ VN+L+ VRLV R
Sbjct: 1653 NMTHTDAVNLLRAASKTVRLVIGR 1676
Score = 48.0 bits (109), Expect = 1e-04
Identities = 32/92 (34%), Positives = 46/92 (50%), Gaps = 3/92 (3%)
Query: 193 EIEIIHVDLNKNVYGLGITVA---GYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRII 249
E V L KN GLG + + + E+ S + VK + G A +SGKI + D I+
Sbjct: 1305 EENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVIL 1364
Query: 250 EVDGISLADKSNPQSVEILRNTGISVHLVLER 281
+V+G SL S + + LR T V L+L R
Sbjct: 1365 KVNGASLKGLSQQEVISALRGTAPEVFLLLCR 1396
Score = 45.6 bits (103), Expect = 6e-04
Identities = 33/104 (31%), Positives = 55/104 (52%), Gaps = 12/104 (11%)
Query: 13 VELTNDGNGLGF------NLVGGRSTGVVI--KYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V+L + +GLGF NL+ + ++ K + PG A + ++ GD +L+V +
Sbjct: 1311 VKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGAS 1370
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALV 108
L+G + ++V + LR P V LL+ RP P L P+ TAL+
Sbjct: 1371 LKGLSQQEVISALRGTAPEVFLLLCRP--PPGVL--PEIDTALL 1410
Score = 41.1 bits (92), Expect = 0.012
Identities = 26/99 (26%), Positives = 50/99 (50%), Gaps = 5/99 (5%)
Query: 193 EIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVD 252
E+E++ + LG TV + + G +V +I+ A+ G++K DR+I+V+
Sbjct: 1593 EVELLITLIKSEKGSLGFTVT----KGNQRIGCYVHDVIQ-DPAKSDGRLKPGDRLIKVN 1647
Query: 253 GISLADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHL 291
+ + ++ +V +LR +V LV+ R L P+ L
Sbjct: 1648 DTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELPRIPML 1686
Score = 39.1 bits (87), Expect = 0.049
Identities = 27/91 (29%), Positives = 48/91 (52%), Gaps = 8/91 (8%)
Query: 550 EDIVMLVKADQG-LGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNG 608
E ++ L+K+++G LGF++ + V ++ A+ +G + PGDR++ VN
Sbjct: 1595 ELLITLIKSEKGSLGFTVTKGNQRIG-----CYVHDVIQDP-AKSDGRLKPGDRLIKVND 1648
Query: 609 VSIQNATLDQAVQALKGAPRGTVKVGIARPL 639
+ N T AV L+ A + TV++ I R L
Sbjct: 1649 TDVTNMTHTDAVNLLRAASK-TVRLVIGRVL 1678
Score = 36.7 bits (81), Expect = 0.26
Identities = 23/82 (28%), Positives = 37/82 (45%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K GLG S ++ Q ++ + P P G ++ GD +L+VN L GL
Sbjct: 1315 KNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGL 1374
Query: 450 THSEVVNILKQLPDRVRLVCAR 471
+ EV++ L+ V L+ R
Sbjct: 1375 SQQEVISALRGTAPEVFLLLCR 1396
Score = 35.9 bits (79), Expect = 0.45
Identities = 21/77 (27%), Positives = 37/77 (48%), Gaps = 2/77 (2%)
Query: 15 LTNDGNGLGFNLV-GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQV 73
+ ++ LGF + G + G + V+ A D RL+ GD +++V ++ T
Sbjct: 1601 IKSEKGSLGFTVTKGNQRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTNMTHTDA 1659
Query: 74 AAVLRQAGPVVRLLVAR 90
+LR A VRL++ R
Sbjct: 1660 VNLLRAASKTVRLVIGR 1676
Score = 35.5 bits (78), Expect = 0.60
Identities = 29/96 (30%), Positives = 43/96 (44%), Gaps = 4/96 (4%)
Query: 551 DIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVS 610
DI + ++ LGFS+ D + V+ + + P VA G + D + VNGVS
Sbjct: 1692 DITLTCNKEE-LGFSLCGGHDSLYQ---VVYISDINPRSVAAIEGNLQLLDVIHYVNGVS 1747
Query: 611 IQNATLDQAVQALKGAPRGTVKVGIARPLPPQDSSK 646
Q TL++ +AL + V LP SSK
Sbjct: 1748 TQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSK 1783
Score = 34.3 bits (75), Expect = 1.4
Identities = 29/99 (29%), Positives = 46/99 (46%), Gaps = 9/99 (9%)
Query: 13 VELTNDGNGLGFNLVGGRSTGVVIKYVL---PGGVADKDRRLQSGDHVLQVGSVNLRGFT 69
+ LT + LGF+L GG + + Y+ P VA + LQ D + V V+ +G T
Sbjct: 1693 ITLTCNKEELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMT 1752
Query: 70 SEQVAAVLRQAGPVVRLLVAR------PADPATALRAPQ 102
E+V L + P + L R P+ +A+ AP+
Sbjct: 1753 LEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPK 1791
>D21210-1|BAA04751.1| 2466|Homo sapiens protein tyrosine phosphatase
type 2 protein.
Length = 2466
Score = 77.4 bits (182), Expect = 1e-13
Identities = 41/97 (42%), Positives = 59/97 (60%)
Query: 195 EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGI 254
+I V+L KN LGI+V G V GI+VK++I +AE G+I DR++ V+G+
Sbjct: 1346 DIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGV 1405
Query: 255 SLADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHL 291
SL ++ Q+VE LRNTG VHL+LE+ EH+
Sbjct: 1406 SLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHV 1442
Score = 68.5 bits (160), Expect = 7e-11
Identities = 36/94 (38%), Positives = 50/94 (53%), Gaps = 5/94 (5%)
Query: 13 VELTNDGNGLGFNLVGGRST-----GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
VEL + N LG ++ GG +T G+ +K V+P G A+ D R+ GD VL V V+L G
Sbjct: 1350 VELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEG 1409
Query: 68 FTSEQVAAVLRQAGPVVRLLVARPADPATALRAP 101
T +Q LR G VV LL+ + P + P
Sbjct: 1410 ATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVP 1443
Score = 60.9 bits (141), Expect = 1e-08
Identities = 62/242 (25%), Positives = 101/242 (41%), Gaps = 35/242 (14%)
Query: 403 VDVEGGQELRPHH---YIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILK 459
+ V GG H Y+++V+P G G ++ GD +L VN L G TH + V L+
Sbjct: 1361 ISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLR 1420
Query: 460 QLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTS 519
V L+ ++ G P + + + +S K + T +
Sbjct: 1421 NTGQVVHLL-----LEKGQSPT---SKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDY 1472
Query: 520 STATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTV 579
S T N E S SGL S+ED ++ P N ++
Sbjct: 1473 SFVTEENTFEVKLFKNS----SGLGFSFSREDNLI-----------------PEQINASI 1511
Query: 580 IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKG-APRGTVKVGIARP 638
+ V+ L PG A ++G+I GD ++ VNG S++ + + + AL+G AP V + + RP
Sbjct: 1512 VRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPE--VFLLLCRP 1569
Query: 639 LP 640
P
Sbjct: 1570 PP 1571
Score = 60.5 bits (140), Expect = 2e-08
Identities = 36/122 (29%), Positives = 58/122 (47%), Gaps = 3/122 (2%)
Query: 372 KKWKEEIGSDKEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGV 431
K+W ++EI + +KK G+ + + E L +I SV P GP L G
Sbjct: 1060 KRWSIVSSPEREITLVNLKKDAKYGLGFQ-IIGGEKMGRLDLGIFISSVAPGGPADLDGC 1118
Query: 432 LNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCA--RNSIDSGPRPVVNLASDRE 489
L GD L+ VN L G++H + IL+ P+ V LV + + I P V+L ++ +
Sbjct: 1119 LKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMK 1178
Query: 490 GF 491
+
Sbjct: 1179 NY 1180
Score = 58.0 bits (134), Expect = 1e-07
Identities = 32/98 (32%), Positives = 53/98 (54%), Gaps = 6/98 (6%)
Query: 2 VLSTEWAQVEVVELTNDGN-GLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGD 55
++S+ ++ +V L D GLGF ++GG G + I V PGG AD D L+ GD
Sbjct: 1064 IVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGD 1123
Query: 56 HVLQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVARPAD 93
++ V SV+L G + +L+ A V L++++P +
Sbjct: 1124 RLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKE 1161
Score = 57.6 bits (133), Expect = 1e-07
Identities = 31/72 (43%), Positives = 45/72 (62%), Gaps = 1/72 (1%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
V L K D LG S+ + +G I V++++P G AE +G I GDRV++VNGVS++
Sbjct: 1350 VELAKNDNSLGISVTGGVNTSVRHGG-IYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLE 1408
Query: 613 NATLDQAVQALK 624
AT QAV+ L+
Sbjct: 1409 GATHKQAVETLR 1420
Score = 57.2 bits (132), Expect = 2e-07
Identities = 35/94 (37%), Positives = 51/94 (54%), Gaps = 1/94 (1%)
Query: 189 VELPEIEIIHVDLNKNV-YGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDR 247
V PE EI V+L K+ YGLG + G GIF+ S+ G A+ G +K DR
Sbjct: 1065 VSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDR 1124
Query: 248 IIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
+I V+ +SL S+ ++EIL+N V LV+ +
Sbjct: 1125 LISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQ 1158
Score = 51.6 bits (118), Expect = 9e-06
Identities = 29/81 (35%), Positives = 47/81 (58%), Gaps = 2/81 (2%)
Query: 558 ADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLD 617
A GLGF I+ + + I + S+ PGG A+ +G + PGDR++SVN VS++ +
Sbjct: 1081 AKYGLGFQIIG-GEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHH 1139
Query: 618 QAVQALKGAPRGTVKVGIARP 638
A++ L+ AP V I++P
Sbjct: 1140 AAIEILQNAPEDVTLV-ISQP 1159
Score = 50.0 bits (114), Expect = 3e-05
Identities = 43/144 (29%), Positives = 73/144 (50%), Gaps = 15/144 (10%)
Query: 328 EPEPESNTTIDSSVLEVGDLQEPTQEELDQRFDEILAVDKEDIVKKWKEEIGSDKEILVA 387
+P+ ES ++ + + EPT++E L D E+ ++ ++ E+ E+L+
Sbjct: 1720 QPQSESASSSSMDKYHIHHISEPTRQENWTP----LKNDLENHLEDFELEV----ELLIT 1771
Query: 388 EIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLH 447
IK +G SL TV +G Q + Y+ V+ D P G L GD L++VN+ +
Sbjct: 1772 LIKSEKG---SLGFTV-TKGNQRIGC--YVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVT 1824
Query: 448 GLTHSEVVNILKQLPDRVRLVCAR 471
+TH++ VN+L+ VRLV R
Sbjct: 1825 NMTHTDAVNLLRAASKTVRLVIGR 1848
Score = 48.0 bits (109), Expect = 1e-04
Identities = 32/92 (34%), Positives = 46/92 (50%), Gaps = 3/92 (3%)
Query: 193 EIEIIHVDLNKNVYGLGITVA---GYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRII 249
E V L KN GLG + + + E+ S + VK + G A +SGKI + D I+
Sbjct: 1477 EENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVIL 1536
Query: 250 EVDGISLADKSNPQSVEILRNTGISVHLVLER 281
+V+G SL S + + LR T V L+L R
Sbjct: 1537 KVNGASLKGLSQQEVISALRGTAPEVFLLLCR 1568
Score = 45.6 bits (103), Expect = 6e-04
Identities = 33/104 (31%), Positives = 55/104 (52%), Gaps = 12/104 (11%)
Query: 13 VELTNDGNGLGF------NLVGGRSTGVVI--KYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V+L + +GLGF NL+ + ++ K + PG A + ++ GD +L+V +
Sbjct: 1483 VKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGAS 1542
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALV 108
L+G + ++V + LR P V LL+ RP P L P+ TAL+
Sbjct: 1543 LKGLSQQEVISALRGTAPEVFLLLCRP--PPGVL--PEIDTALL 1582
Score = 41.1 bits (92), Expect = 0.012
Identities = 26/99 (26%), Positives = 50/99 (50%), Gaps = 5/99 (5%)
Query: 193 EIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVD 252
E+E++ + LG TV + + G +V +I+ A+ G++K DR+I+V+
Sbjct: 1765 EVELLITLIKSEKGSLGFTVT----KGNQRIGCYVHDVIQ-DPAKSDGRLKPGDRLIKVN 1819
Query: 253 GISLADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHL 291
+ + ++ +V +LR +V LV+ R L P+ L
Sbjct: 1820 DTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELPRIPML 1858
Score = 39.1 bits (87), Expect = 0.049
Identities = 27/91 (29%), Positives = 48/91 (52%), Gaps = 8/91 (8%)
Query: 550 EDIVMLVKADQG-LGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNG 608
E ++ L+K+++G LGF++ + V ++ A+ +G + PGDR++ VN
Sbjct: 1767 ELLITLIKSEKGSLGFTVTKGNQRIG-----CYVHDVIQDP-AKSDGRLKPGDRLIKVND 1820
Query: 609 VSIQNATLDQAVQALKGAPRGTVKVGIARPL 639
+ N T AV L+ A + TV++ I R L
Sbjct: 1821 TDVTNMTHTDAVNLLRAASK-TVRLVIGRVL 1850
Score = 36.7 bits (81), Expect = 0.26
Identities = 23/82 (28%), Positives = 37/82 (45%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K GLG S ++ Q ++ + P P G ++ GD +L+VN L GL
Sbjct: 1487 KNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGL 1546
Query: 450 THSEVVNILKQLPDRVRLVCAR 471
+ EV++ L+ V L+ R
Sbjct: 1547 SQQEVISALRGTAPEVFLLLCR 1568
Score = 35.9 bits (79), Expect = 0.45
Identities = 21/77 (27%), Positives = 37/77 (48%), Gaps = 2/77 (2%)
Query: 15 LTNDGNGLGFNLV-GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQV 73
+ ++ LGF + G + G + V+ A D RL+ GD +++V ++ T
Sbjct: 1773 IKSEKGSLGFTVTKGNQRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTNMTHTDA 1831
Query: 74 AAVLRQAGPVVRLLVAR 90
+LR A VRL++ R
Sbjct: 1832 VNLLRAASKTVRLVIGR 1848
Score = 35.5 bits (78), Expect = 0.60
Identities = 29/96 (30%), Positives = 43/96 (44%), Gaps = 4/96 (4%)
Query: 551 DIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVS 610
DI + ++ LGFS+ D + V+ + + P VA G + D + VNGVS
Sbjct: 1864 DITLTCNKEE-LGFSLCGGHDSLYQ---VVYISDINPRSVAAIEGNLQLLDVIHYVNGVS 1919
Query: 611 IQNATLDQAVQALKGAPRGTVKVGIARPLPPQDSSK 646
Q TL++ +AL + V LP SSK
Sbjct: 1920 TQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSK 1955
Score = 34.3 bits (75), Expect = 1.4
Identities = 29/99 (29%), Positives = 46/99 (46%), Gaps = 9/99 (9%)
Query: 13 VELTNDGNGLGFNLVGGRSTGVVIKYVL---PGGVADKDRRLQSGDHVLQVGSVNLRGFT 69
+ LT + LGF+L GG + + Y+ P VA + LQ D + V V+ +G T
Sbjct: 1865 ITLTCNKEELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMT 1924
Query: 70 SEQVAAVLRQAGPVVRLLVAR------PADPATALRAPQ 102
E+V L + P + L R P+ +A+ AP+
Sbjct: 1925 LEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPK 1963
>D21209-1|BAA04750.1| 2485|Homo sapiens protein tyrosine phosphatase
type 1 protein.
Length = 2485
Score = 77.4 bits (182), Expect = 1e-13
Identities = 41/97 (42%), Positives = 59/97 (60%)
Query: 195 EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGI 254
+I V+L KN LGI+V G V GI+VK++I +AE G+I DR++ V+G+
Sbjct: 1365 DIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGV 1424
Query: 255 SLADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHL 291
SL ++ Q+VE LRNTG VHL+LE+ EH+
Sbjct: 1425 SLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHV 1461
Score = 68.5 bits (160), Expect = 7e-11
Identities = 36/94 (38%), Positives = 50/94 (53%), Gaps = 5/94 (5%)
Query: 13 VELTNDGNGLGFNLVGGRST-----GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
VEL + N LG ++ GG +T G+ +K V+P G A+ D R+ GD VL V V+L G
Sbjct: 1369 VELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEG 1428
Query: 68 FTSEQVAAVLRQAGPVVRLLVARPADPATALRAP 101
T +Q LR G VV LL+ + P + P
Sbjct: 1429 ATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVP 1462
Score = 61.3 bits (142), Expect = 1e-08
Identities = 42/167 (25%), Positives = 74/167 (44%), Gaps = 5/167 (2%)
Query: 329 PEPESNTTIDSSVLEVGD--LQEPTQEELDQRFDEILAVDKEDIVKKWKEEIGSDKEILV 386
PE + + SS+ + G + T ++ + + + K+W ++EI +
Sbjct: 1034 PERRKHESDSSSIEDPGQAYVLGMTMHSSGNSSSQVPLKENDVLHKRWSIVSSPEREITL 1093
Query: 387 AEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRL 446
+KK G+ + + E L +I SV P GP L G L GD L+ VN L
Sbjct: 1094 VNLKKDAKYGLGFQ-IIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSL 1152
Query: 447 HGLTHSEVVNILKQLPDRVRLVCA--RNSIDSGPRPVVNLASDREGF 491
G++H + IL+ P+ V LV + + I P V+L ++ + +
Sbjct: 1153 EGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNY 1199
Score = 60.9 bits (141), Expect = 1e-08
Identities = 62/242 (25%), Positives = 101/242 (41%), Gaps = 35/242 (14%)
Query: 403 VDVEGGQELRPHH---YIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILK 459
+ V GG H Y+++V+P G G ++ GD +L VN L G TH + V L+
Sbjct: 1380 ISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLR 1439
Query: 460 QLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTS 519
V L+ ++ G P + + + +S K + T +
Sbjct: 1440 NTGQVVHLL-----LEKGQSPT---SKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDY 1491
Query: 520 STATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTV 579
S T N E S SGL S+ED ++ P N ++
Sbjct: 1492 SFVTEENTFEVKLFKNS----SGLGFSFSREDNLI-----------------PEQINASI 1530
Query: 580 IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKG-APRGTVKVGIARP 638
+ V+ L PG A ++G+I GD ++ VNG S++ + + + AL+G AP V + + RP
Sbjct: 1531 VRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPE--VFLLLCRP 1588
Query: 639 LP 640
P
Sbjct: 1589 PP 1590
Score = 58.0 bits (134), Expect = 1e-07
Identities = 32/98 (32%), Positives = 53/98 (54%), Gaps = 6/98 (6%)
Query: 2 VLSTEWAQVEVVELTNDGN-GLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGD 55
++S+ ++ +V L D GLGF ++GG G + I V PGG AD D L+ GD
Sbjct: 1083 IVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGD 1142
Query: 56 HVLQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVARPAD 93
++ V SV+L G + +L+ A V L++++P +
Sbjct: 1143 RLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKE 1180
Score = 57.6 bits (133), Expect = 1e-07
Identities = 31/72 (43%), Positives = 45/72 (62%), Gaps = 1/72 (1%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
V L K D LG S+ + +G I V++++P G AE +G I GDRV++VNGVS++
Sbjct: 1369 VELAKNDNSLGISVTGGVNTSVRHGG-IYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLE 1427
Query: 613 NATLDQAVQALK 624
AT QAV+ L+
Sbjct: 1428 GATHKQAVETLR 1439
Score = 57.2 bits (132), Expect = 2e-07
Identities = 35/94 (37%), Positives = 51/94 (54%), Gaps = 1/94 (1%)
Query: 189 VELPEIEIIHVDLNKNV-YGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDR 247
V PE EI V+L K+ YGLG + G GIF+ S+ G A+ G +K DR
Sbjct: 1084 VSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDR 1143
Query: 248 IIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
+I V+ +SL S+ ++EIL+N V LV+ +
Sbjct: 1144 LISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQ 1177
Score = 51.6 bits (118), Expect = 9e-06
Identities = 29/81 (35%), Positives = 47/81 (58%), Gaps = 2/81 (2%)
Query: 558 ADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLD 617
A GLGF I+ + + I + S+ PGG A+ +G + PGDR++SVN VS++ +
Sbjct: 1100 AKYGLGFQIIG-GEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHH 1158
Query: 618 QAVQALKGAPRGTVKVGIARP 638
A++ L+ AP V I++P
Sbjct: 1159 AAIEILQNAPEDVTLV-ISQP 1178
Score = 50.0 bits (114), Expect = 3e-05
Identities = 43/144 (29%), Positives = 73/144 (50%), Gaps = 15/144 (10%)
Query: 328 EPEPESNTTIDSSVLEVGDLQEPTQEELDQRFDEILAVDKEDIVKKWKEEIGSDKEILVA 387
+P+ ES ++ + + EPT++E L D E+ ++ ++ E+ E+L+
Sbjct: 1739 QPQSESASSSSMDKYHIHHISEPTRQENWTP----LKNDLENHLEDFELEV----ELLIT 1790
Query: 388 EIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLH 447
IK +G SL TV +G Q + Y+ V+ D P G L GD L++VN+ +
Sbjct: 1791 LIKSEKG---SLGFTV-TKGNQRIGC--YVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVT 1843
Query: 448 GLTHSEVVNILKQLPDRVRLVCAR 471
+TH++ VN+L+ VRLV R
Sbjct: 1844 NMTHTDAVNLLRAASKTVRLVIGR 1867
Score = 48.0 bits (109), Expect = 1e-04
Identities = 32/92 (34%), Positives = 46/92 (50%), Gaps = 3/92 (3%)
Query: 193 EIEIIHVDLNKNVYGLGITVA---GYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRII 249
E V L KN GLG + + + E+ S + VK + G A +SGKI + D I+
Sbjct: 1496 EENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVIL 1555
Query: 250 EVDGISLADKSNPQSVEILRNTGISVHLVLER 281
+V+G SL S + + LR T V L+L R
Sbjct: 1556 KVNGASLKGLSQQEVISALRGTAPEVFLLLCR 1587
Score = 45.6 bits (103), Expect = 6e-04
Identities = 33/104 (31%), Positives = 55/104 (52%), Gaps = 12/104 (11%)
Query: 13 VELTNDGNGLGF------NLVGGRSTGVVI--KYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V+L + +GLGF NL+ + ++ K + PG A + ++ GD +L+V +
Sbjct: 1502 VKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGAS 1561
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALV 108
L+G + ++V + LR P V LL+ RP P L P+ TAL+
Sbjct: 1562 LKGLSQQEVISALRGTAPEVFLLLCRP--PPGVL--PEIDTALL 1601
Score = 41.1 bits (92), Expect = 0.012
Identities = 26/99 (26%), Positives = 50/99 (50%), Gaps = 5/99 (5%)
Query: 193 EIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVD 252
E+E++ + LG TV + + G +V +I+ A+ G++K DR+I+V+
Sbjct: 1784 EVELLITLIKSEKGSLGFTVT----KGNQRIGCYVHDVIQ-DPAKSDGRLKPGDRLIKVN 1838
Query: 253 GISLADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHL 291
+ + ++ +V +LR +V LV+ R L P+ L
Sbjct: 1839 DTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELPRIPML 1877
Score = 39.1 bits (87), Expect = 0.049
Identities = 27/91 (29%), Positives = 48/91 (52%), Gaps = 8/91 (8%)
Query: 550 EDIVMLVKADQG-LGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNG 608
E ++ L+K+++G LGF++ + V ++ A+ +G + PGDR++ VN
Sbjct: 1786 ELLITLIKSEKGSLGFTVTKGNQRIG-----CYVHDVIQDP-AKSDGRLKPGDRLIKVND 1839
Query: 609 VSIQNATLDQAVQALKGAPRGTVKVGIARPL 639
+ N T AV L+ A + TV++ I R L
Sbjct: 1840 TDVTNMTHTDAVNLLRAASK-TVRLVIGRVL 1869
Score = 36.7 bits (81), Expect = 0.26
Identities = 23/82 (28%), Positives = 37/82 (45%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K GLG S ++ Q ++ + P P G ++ GD +L+VN L GL
Sbjct: 1506 KNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGL 1565
Query: 450 THSEVVNILKQLPDRVRLVCAR 471
+ EV++ L+ V L+ R
Sbjct: 1566 SQQEVISALRGTAPEVFLLLCR 1587
Score = 35.9 bits (79), Expect = 0.45
Identities = 21/77 (27%), Positives = 37/77 (48%), Gaps = 2/77 (2%)
Query: 15 LTNDGNGLGFNLV-GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQV 73
+ ++ LGF + G + G + V+ A D RL+ GD +++V ++ T
Sbjct: 1792 IKSEKGSLGFTVTKGNQRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTNMTHTDA 1850
Query: 74 AAVLRQAGPVVRLLVAR 90
+LR A VRL++ R
Sbjct: 1851 VNLLRAASKTVRLVIGR 1867
Score = 35.5 bits (78), Expect = 0.60
Identities = 29/96 (30%), Positives = 43/96 (44%), Gaps = 4/96 (4%)
Query: 551 DIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVS 610
DI + ++ LGFS+ D + V+ + + P VA G + D + VNGVS
Sbjct: 1883 DITLTCNKEE-LGFSLCGGHDSLYQ---VVYISDINPRSVAAIEGNLQLLDVIHYVNGVS 1938
Query: 611 IQNATLDQAVQALKGAPRGTVKVGIARPLPPQDSSK 646
Q TL++ +AL + V LP SSK
Sbjct: 1939 TQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSK 1974
Score = 34.3 bits (75), Expect = 1.4
Identities = 29/99 (29%), Positives = 46/99 (46%), Gaps = 9/99 (9%)
Query: 13 VELTNDGNGLGFNLVGGRSTGVVIKYVL---PGGVADKDRRLQSGDHVLQVGSVNLRGFT 69
+ LT + LGF+L GG + + Y+ P VA + LQ D + V V+ +G T
Sbjct: 1884 ITLTCNKEELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMT 1943
Query: 70 SEQVAAVLRQAGPVVRLLVAR------PADPATALRAPQ 102
E+V L + P + L R P+ +A+ AP+
Sbjct: 1944 LEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPK 1982
>BC039610-1|AAH39610.1| 604|Homo sapiens PTPN13 protein protein.
Length = 604
Score = 77.4 bits (182), Expect = 1e-13
Identities = 41/97 (42%), Positives = 59/97 (60%)
Query: 195 EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGI 254
+I V+L KN LGI+V G V GI+VK++I +AE G+I DR++ V+G+
Sbjct: 43 DIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGV 102
Query: 255 SLADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHL 291
SL ++ Q+VE LRNTG VHL+LE+ EH+
Sbjct: 103 SLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHV 139
Score = 68.5 bits (160), Expect = 7e-11
Identities = 36/94 (38%), Positives = 50/94 (53%), Gaps = 5/94 (5%)
Query: 13 VELTNDGNGLGFNLVGGRST-----GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
VEL + N LG ++ GG +T G+ +K V+P G A+ D R+ GD VL V V+L G
Sbjct: 47 VELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEG 106
Query: 68 FTSEQVAAVLRQAGPVVRLLVARPADPATALRAP 101
T +Q LR G VV LL+ + P + P
Sbjct: 107 ATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVP 140
Score = 60.9 bits (141), Expect = 1e-08
Identities = 62/242 (25%), Positives = 101/242 (41%), Gaps = 35/242 (14%)
Query: 403 VDVEGGQELRPHH---YIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILK 459
+ V GG H Y+++V+P G G ++ GD +L VN L G TH + V L+
Sbjct: 58 ISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLR 117
Query: 460 QLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTS 519
V L+ ++ G P + + + +S K + T +
Sbjct: 118 NTGQVVHLL-----LEKGQSPT---SKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDY 169
Query: 520 STATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTV 579
S T N E S SGL S+ED ++ P N ++
Sbjct: 170 SFVTEENTFEVKLFKNS----SGLGFSFSREDNLI-----------------PEQINASI 208
Query: 580 IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKG-APRGTVKVGIARP 638
+ V+ L PG A ++G+I GD ++ VNG S++ + + + AL+G AP V + + RP
Sbjct: 209 VRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPE--VFLLLCRP 266
Query: 639 LP 640
P
Sbjct: 267 PP 268
Score = 57.6 bits (133), Expect = 1e-07
Identities = 31/72 (43%), Positives = 45/72 (62%), Gaps = 1/72 (1%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
V L K D LG S+ + +G I V++++P G AE +G I GDRV++VNGVS++
Sbjct: 47 VELAKNDNSLGISVTGGVNTSVRHGG-IYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLE 105
Query: 613 NATLDQAVQALK 624
AT QAV+ L+
Sbjct: 106 GATHKQAVETLR 117
Score = 50.0 bits (114), Expect = 3e-05
Identities = 43/144 (29%), Positives = 73/144 (50%), Gaps = 15/144 (10%)
Query: 328 EPEPESNTTIDSSVLEVGDLQEPTQEELDQRFDEILAVDKEDIVKKWKEEIGSDKEILVA 387
+P+ ES ++ + + EPT++E L D E+ ++ ++ E+ E+L+
Sbjct: 417 QPQSESASSSSMDKYHIHHISEPTRQENWTP----LKNDLENHLEDFELEV----ELLIT 468
Query: 388 EIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLH 447
IK +G SL TV +G Q + Y+ V+ D P G L GD L++VN+ +
Sbjct: 469 LIKSEKG---SLGFTV-TKGNQRIGC--YVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVT 521
Query: 448 GLTHSEVVNILKQLPDRVRLVCAR 471
+TH++ VN+L+ VRLV R
Sbjct: 522 NMTHTDAVNLLRAASKTVRLVIGR 545
Score = 48.0 bits (109), Expect = 1e-04
Identities = 32/92 (34%), Positives = 46/92 (50%), Gaps = 3/92 (3%)
Query: 193 EIEIIHVDLNKNVYGLGITVA---GYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRII 249
E V L KN GLG + + + E+ S + VK + G A +SGKI + D I+
Sbjct: 174 EENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVIL 233
Query: 250 EVDGISLADKSNPQSVEILRNTGISVHLVLER 281
+V+G SL S + + LR T V L+L R
Sbjct: 234 KVNGASLKGLSQQEVISALRGTAPEVFLLLCR 265
Score = 45.6 bits (103), Expect = 6e-04
Identities = 33/104 (31%), Positives = 55/104 (52%), Gaps = 12/104 (11%)
Query: 13 VELTNDGNGLGF------NLVGGRSTGVVI--KYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V+L + +GLGF NL+ + ++ K + PG A + ++ GD +L+V +
Sbjct: 180 VKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGAS 239
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALV 108
L+G + ++V + LR P V LL+ RP P L P+ TAL+
Sbjct: 240 LKGLSQQEVISALRGTAPEVFLLLCRP--PPGVL--PEIDTALL 279
Score = 41.1 bits (92), Expect = 0.012
Identities = 26/99 (26%), Positives = 50/99 (50%), Gaps = 5/99 (5%)
Query: 193 EIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVD 252
E+E++ + LG TV + + G +V +I+ A+ G++K DR+I+V+
Sbjct: 462 EVELLITLIKSEKGSLGFTVT----KGNQRIGCYVHDVIQ-DPAKSDGRLKPGDRLIKVN 516
Query: 253 GISLADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHL 291
+ + ++ +V +LR +V LV+ R L P+ L
Sbjct: 517 DTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELPRIPML 555
Score = 39.1 bits (87), Expect = 0.049
Identities = 27/91 (29%), Positives = 48/91 (52%), Gaps = 8/91 (8%)
Query: 550 EDIVMLVKADQG-LGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNG 608
E ++ L+K+++G LGF++ + V ++ A+ +G + PGDR++ VN
Sbjct: 464 ELLITLIKSEKGSLGFTVTKGNQRIG-----CYVHDVIQDP-AKSDGRLKPGDRLIKVND 517
Query: 609 VSIQNATLDQAVQALKGAPRGTVKVGIARPL 639
+ N T AV L+ A + TV++ I R L
Sbjct: 518 TDVTNMTHTDAVNLLRAASK-TVRLVIGRVL 547
Score = 36.7 bits (81), Expect = 0.26
Identities = 23/82 (28%), Positives = 37/82 (45%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K GLG S ++ Q ++ + P P G ++ GD +L+VN L GL
Sbjct: 184 KNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGL 243
Query: 450 THSEVVNILKQLPDRVRLVCAR 471
+ EV++ L+ V L+ R
Sbjct: 244 SQQEVISALRGTAPEVFLLLCR 265
Score = 35.9 bits (79), Expect = 0.45
Identities = 21/77 (27%), Positives = 37/77 (48%), Gaps = 2/77 (2%)
Query: 15 LTNDGNGLGFNLV-GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQV 73
+ ++ LGF + G + G + V+ A D RL+ GD +++V ++ T
Sbjct: 470 IKSEKGSLGFTVTKGNQRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTNMTHTDA 528
Query: 74 AAVLRQAGPVVRLLVAR 90
+LR A VRL++ R
Sbjct: 529 VNLLRAASKTVRLVIGR 545
>AF233323-1|AAF63474.1| 499|Homo sapiens Fas-associated
phosphatase-1 protein.
Length = 499
Score = 77.4 bits (182), Expect = 1e-13
Identities = 41/97 (42%), Positives = 59/97 (60%)
Query: 195 EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGI 254
+I V+L KN LGI+V G V GI+VK++I +AE G+I DR++ V+G+
Sbjct: 43 DIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGV 102
Query: 255 SLADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHL 291
SL ++ Q+VE LRNTG VHL+LE+ EH+
Sbjct: 103 SLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHV 139
Score = 68.5 bits (160), Expect = 7e-11
Identities = 36/94 (38%), Positives = 50/94 (53%), Gaps = 5/94 (5%)
Query: 13 VELTNDGNGLGFNLVGGRST-----GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
VEL + N LG ++ GG +T G+ +K V+P G A+ D R+ GD VL V V+L G
Sbjct: 47 VELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEG 106
Query: 68 FTSEQVAAVLRQAGPVVRLLVARPADPATALRAP 101
T +Q LR G VV LL+ + P + P
Sbjct: 107 ATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVP 140
Score = 60.9 bits (141), Expect = 1e-08
Identities = 62/242 (25%), Positives = 101/242 (41%), Gaps = 35/242 (14%)
Query: 403 VDVEGGQELRPHH---YIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILK 459
+ V GG H Y+++V+P G G ++ GD +L VN L G TH + V L+
Sbjct: 58 ISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLR 117
Query: 460 QLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTS 519
V L+ ++ G P + + + +S K + T +
Sbjct: 118 NTGQVVHLL-----LEKGQSPT---SKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDY 169
Query: 520 STATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTV 579
S T N E S SGL S+ED ++ P N ++
Sbjct: 170 SFVTEENTFEVKLFKNS----SGLGFSFSREDNLI-----------------PEQINASI 208
Query: 580 IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKG-APRGTVKVGIARP 638
+ V+ L PG A ++G+I GD ++ VNG S++ + + + AL+G AP V + + RP
Sbjct: 209 VRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPE--VFLLLCRP 266
Query: 639 LP 640
P
Sbjct: 267 PP 268
Score = 57.6 bits (133), Expect = 1e-07
Identities = 31/72 (43%), Positives = 45/72 (62%), Gaps = 1/72 (1%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
V L K D LG S+ + +G I V++++P G AE +G I GDRV++VNGVS++
Sbjct: 47 VELAKNDNSLGISVTGGVNTSVRHGG-IYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLE 105
Query: 613 NATLDQAVQALK 624
AT QAV+ L+
Sbjct: 106 GATHKQAVETLR 117
Score = 48.0 bits (109), Expect = 1e-04
Identities = 32/92 (34%), Positives = 46/92 (50%), Gaps = 3/92 (3%)
Query: 193 EIEIIHVDLNKNVYGLGITVA---GYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRII 249
E V L KN GLG + + + E+ S + VK + G A +SGKI + D I+
Sbjct: 174 EENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVIL 233
Query: 250 EVDGISLADKSNPQSVEILRNTGISVHLVLER 281
+V+G SL S + + LR T V L+L R
Sbjct: 234 KVNGASLKGLSQQEVISALRGTAPEVFLLLCR 265
Score = 45.6 bits (103), Expect = 6e-04
Identities = 33/104 (31%), Positives = 55/104 (52%), Gaps = 12/104 (11%)
Query: 13 VELTNDGNGLGF------NLVGGRSTGVVI--KYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V+L + +GLGF NL+ + ++ K + PG A + ++ GD +L+V +
Sbjct: 180 VKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGAS 239
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALV 108
L+G + ++V + LR P V LL+ RP P L P+ TAL+
Sbjct: 240 LKGLSQQEVISALRGTAPEVFLLLCRP--PPGVL--PEIDTALL 279
Score = 36.7 bits (81), Expect = 0.26
Identities = 23/82 (28%), Positives = 37/82 (45%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K GLG S ++ Q ++ + P P G ++ GD +L+VN L GL
Sbjct: 184 KNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGL 243
Query: 450 THSEVVNILKQLPDRVRLVCAR 471
+ EV++ L+ V L+ R
Sbjct: 244 SQQEVISALRGTAPEVFLLLCR 265
>AB208904-1|BAD92141.1| 2434|Homo sapiens protein tyrosine
phosphatase, non-receptor type 13 isoform 2 variant
protein.
Length = 2434
Score = 77.4 bits (182), Expect = 1e-13
Identities = 43/98 (43%), Positives = 62/98 (63%), Gaps = 2/98 (2%)
Query: 195 EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGI 254
+I V+L KN LGI+V G V GI+VK++I +AE G+I DR++ V+G+
Sbjct: 1314 DIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGV 1373
Query: 255 SLADKSNPQSVEILRNTGISVHLVLERYLRGPKF-EHL 291
SL ++ Q+VE LRNTG VHL+LE+ + P F EH+
Sbjct: 1374 SLEGATHKQAVETLRNTGQVVHLLLEKG-QSPTFKEHV 1410
Score = 67.3 bits (157), Expect = 2e-10
Identities = 36/94 (38%), Positives = 49/94 (52%), Gaps = 5/94 (5%)
Query: 13 VELTNDGNGLGFNLVGGRST-----GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
VEL + N LG ++ GG +T G+ +K V+P G A+ D R+ GD VL V V+L G
Sbjct: 1318 VELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEG 1377
Query: 68 FTSEQVAAVLRQAGPVVRLLVARPADPATALRAP 101
T +Q LR G VV LL+ + P P
Sbjct: 1378 ATHKQAVETLRNTGQVVHLLLEKGQSPTFKEHVP 1411
Score = 60.5 bits (140), Expect = 2e-08
Identities = 36/122 (29%), Positives = 58/122 (47%), Gaps = 3/122 (2%)
Query: 372 KKWKEEIGSDKEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGV 431
K+W ++EI + +KK G+ + + E L +I SV P GP L G
Sbjct: 1028 KRWSIVSSPEREITLVNLKKDAKYGLGFQ-IIGGEKMGRLDLGIFISSVAPGGPADLDGC 1086
Query: 432 LNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCA--RNSIDSGPRPVVNLASDRE 489
L GD L+ VN L G++H + IL+ P+ V LV + + I P V+L ++ +
Sbjct: 1087 LKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMK 1146
Query: 490 GF 491
+
Sbjct: 1147 NY 1148
Score = 60.1 bits (139), Expect = 2e-08
Identities = 62/242 (25%), Positives = 100/242 (41%), Gaps = 35/242 (14%)
Query: 403 VDVEGGQELRPHH---YIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILK 459
+ V GG H Y+++V+P G G ++ GD +L VN L G TH + V L+
Sbjct: 1329 ISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLR 1388
Query: 460 QLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTS 519
V L+ ++ G P + + +S K + T +
Sbjct: 1389 NTGQVVHLL-----LEKGQSPTF---KEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDY 1440
Query: 520 STATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTV 579
S T N E S SGL S+ED ++ P N ++
Sbjct: 1441 SFVTEENTFEVKLFKNS----SGLGFSFSREDNLI-----------------PEQINASI 1479
Query: 580 IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKG-APRGTVKVGIARP 638
+ V+ L PG A ++G+I GD ++ VNG S++ + + + AL+G AP V + + RP
Sbjct: 1480 VRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPE--VFLLLCRP 1537
Query: 639 LP 640
P
Sbjct: 1538 PP 1539
Score = 58.0 bits (134), Expect = 1e-07
Identities = 32/98 (32%), Positives = 53/98 (54%), Gaps = 6/98 (6%)
Query: 2 VLSTEWAQVEVVELTNDGN-GLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGD 55
++S+ ++ +V L D GLGF ++GG G + I V PGG AD D L+ GD
Sbjct: 1032 IVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGD 1091
Query: 56 HVLQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVARPAD 93
++ V SV+L G + +L+ A V L++++P +
Sbjct: 1092 RLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKE 1129
Score = 57.6 bits (133), Expect = 1e-07
Identities = 31/72 (43%), Positives = 45/72 (62%), Gaps = 1/72 (1%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
V L K D LG S+ + +G I V++++P G AE +G I GDRV++VNGVS++
Sbjct: 1318 VELAKNDNSLGISVTGGVNTSVRHGG-IYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLE 1376
Query: 613 NATLDQAVQALK 624
AT QAV+ L+
Sbjct: 1377 GATHKQAVETLR 1388
Score = 57.2 bits (132), Expect = 2e-07
Identities = 35/94 (37%), Positives = 51/94 (54%), Gaps = 1/94 (1%)
Query: 189 VELPEIEIIHVDLNKNV-YGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDR 247
V PE EI V+L K+ YGLG + G GIF+ S+ G A+ G +K DR
Sbjct: 1033 VSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDR 1092
Query: 248 IIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
+I V+ +SL S+ ++EIL+N V LV+ +
Sbjct: 1093 LISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQ 1126
Score = 51.6 bits (118), Expect = 9e-06
Identities = 29/81 (35%), Positives = 47/81 (58%), Gaps = 2/81 (2%)
Query: 558 ADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLD 617
A GLGF I+ + + I + S+ PGG A+ +G + PGDR++SVN VS++ +
Sbjct: 1049 AKYGLGFQIIG-GEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHH 1107
Query: 618 QAVQALKGAPRGTVKVGIARP 638
A++ L+ AP V I++P
Sbjct: 1108 AAIEILQNAPEDVTLV-ISQP 1127
Score = 50.0 bits (114), Expect = 3e-05
Identities = 43/144 (29%), Positives = 73/144 (50%), Gaps = 15/144 (10%)
Query: 328 EPEPESNTTIDSSVLEVGDLQEPTQEELDQRFDEILAVDKEDIVKKWKEEIGSDKEILVA 387
+P+ ES ++ + + EPT++E L D E+ ++ ++ E+ E+L+
Sbjct: 1688 QPQSESASSSSMDKYHIHHISEPTRQENWTP----LKNDLENHLEDFELEV----ELLIT 1739
Query: 388 EIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLH 447
IK +G SL TV +G Q + Y+ V+ D P G L GD L++VN+ +
Sbjct: 1740 LIKSEKG---SLGFTV-TKGNQRIGC--YVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVT 1792
Query: 448 GLTHSEVVNILKQLPDRVRLVCAR 471
+TH++ VN+L+ VRLV R
Sbjct: 1793 NMTHTDAVNLLRAASKTVRLVIGR 1816
Score = 48.0 bits (109), Expect = 1e-04
Identities = 32/92 (34%), Positives = 46/92 (50%), Gaps = 3/92 (3%)
Query: 193 EIEIIHVDLNKNVYGLGITVA---GYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRII 249
E V L KN GLG + + + E+ S + VK + G A +SGKI + D I+
Sbjct: 1445 EENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVIL 1504
Query: 250 EVDGISLADKSNPQSVEILRNTGISVHLVLER 281
+V+G SL S + + LR T V L+L R
Sbjct: 1505 KVNGASLKGLSQQEVISALRGTAPEVFLLLCR 1536
Score = 45.6 bits (103), Expect = 6e-04
Identities = 33/104 (31%), Positives = 55/104 (52%), Gaps = 12/104 (11%)
Query: 13 VELTNDGNGLGF------NLVGGRSTGVVI--KYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V+L + +GLGF NL+ + ++ K + PG A + ++ GD +L+V +
Sbjct: 1451 VKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGAS 1510
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALV 108
L+G + ++V + LR P V LL+ RP P L P+ TAL+
Sbjct: 1511 LKGLSQQEVISALRGTAPEVFLLLCRP--PPGVL--PEIDTALL 1550
Score = 41.1 bits (92), Expect = 0.012
Identities = 26/99 (26%), Positives = 50/99 (50%), Gaps = 5/99 (5%)
Query: 193 EIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVD 252
E+E++ + LG TV + + G +V +I+ A+ G++K DR+I+V+
Sbjct: 1733 EVELLITLIKSEKGSLGFTVT----KGNQRIGCYVHDVIQ-DPAKSDGRLKPGDRLIKVN 1787
Query: 253 GISLADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHL 291
+ + ++ +V +LR +V LV+ R L P+ L
Sbjct: 1788 DTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELPRIPML 1826
Score = 39.1 bits (87), Expect = 0.049
Identities = 27/91 (29%), Positives = 48/91 (52%), Gaps = 8/91 (8%)
Query: 550 EDIVMLVKADQG-LGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNG 608
E ++ L+K+++G LGF++ + V ++ A+ +G + PGDR++ VN
Sbjct: 1735 ELLITLIKSEKGSLGFTVTKGNQRIG-----CYVHDVIQDP-AKSDGRLKPGDRLIKVND 1788
Query: 609 VSIQNATLDQAVQALKGAPRGTVKVGIARPL 639
+ N T AV L+ A + TV++ I R L
Sbjct: 1789 TDVTNMTHTDAVNLLRAASK-TVRLVIGRVL 1818
Score = 36.7 bits (81), Expect = 0.26
Identities = 23/82 (28%), Positives = 37/82 (45%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K GLG S ++ Q ++ + P P G ++ GD +L+VN L GL
Sbjct: 1455 KNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGL 1514
Query: 450 THSEVVNILKQLPDRVRLVCAR 471
+ EV++ L+ V L+ R
Sbjct: 1515 SQQEVISALRGTAPEVFLLLCR 1536
Score = 35.9 bits (79), Expect = 0.45
Identities = 21/77 (27%), Positives = 37/77 (48%), Gaps = 2/77 (2%)
Query: 15 LTNDGNGLGFNLV-GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQV 73
+ ++ LGF + G + G + V+ A D RL+ GD +++V ++ T
Sbjct: 1741 IKSEKGSLGFTVTKGNQRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTNMTHTDA 1799
Query: 74 AAVLRQAGPVVRLLVAR 90
+LR A VRL++ R
Sbjct: 1800 VNLLRAASKTVRLVIGR 1816
Score = 35.5 bits (78), Expect = 0.60
Identities = 29/96 (30%), Positives = 43/96 (44%), Gaps = 4/96 (4%)
Query: 551 DIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVS 610
DI + ++ LGFS+ D + V+ + + P VA G + D + VNGVS
Sbjct: 1832 DITLTCNKEE-LGFSLCGGHDSLYQ---VVYISDINPRSVAAIEGNLQLLDVIHYVNGVS 1887
Query: 611 IQNATLDQAVQALKGAPRGTVKVGIARPLPPQDSSK 646
Q TL++ +AL + V LP SSK
Sbjct: 1888 TQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSK 1923
Score = 34.3 bits (75), Expect = 1.4
Identities = 29/99 (29%), Positives = 46/99 (46%), Gaps = 9/99 (9%)
Query: 13 VELTNDGNGLGFNLVGGRSTGVVIKYVL---PGGVADKDRRLQSGDHVLQVGSVNLRGFT 69
+ LT + LGF+L GG + + Y+ P VA + LQ D + V V+ +G T
Sbjct: 1833 ITLTCNKEELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMT 1892
Query: 70 SEQVAAVLRQAGPVVRLLVAR------PADPATALRAPQ 102
E+V L + P + L R P+ +A+ AP+
Sbjct: 1893 LEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPK 1931
>BC130449-1|AAI30450.1| 1253|Homo sapiens PPP1R9A protein protein.
Length = 1253
Score = 76.6 bits (180), Expect = 3e-13
Identities = 61/222 (27%), Positives = 106/222 (47%), Gaps = 11/222 (4%)
Query: 177 DSVSPTITITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKE---ELSGIFVKSIIEG 233
D V+ + + + ++E+ V+L K+ GLGI++ G + E GIFVK++ EG
Sbjct: 483 DPVAASAEYELEKRVEKLELFPVELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEG 542
Query: 234 SSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHLQL 293
+A++ G+I++ND+I+EVDGISL + + +LRNT +V V+ R G E QL
Sbjct: 543 GAAQRDGRIQVNDQIVEVDGISLVGVTQNFAATVLRNTKGNVRFVIGREKPGQVSEVAQL 602
Query: 294 --AIFNEERXXXXXXXXXXLSWFPVPSQLENSITEIEPEPESNTTIDSSVLEVGDLQEPT 351
+ER + + T+ E E E + S + + + P
Sbjct: 603 ISQTLEQERRQRELLEQHYAQYDADDDETGEYATD-EEEDEVGPVLPGSDMAIEVFELPE 661
Query: 352 QEELDQRFDEILAVDKEDIVKKWKEEIGSDKEILVAEIKKLE 393
E++ + +D + K+K E+ + AEI+KL+
Sbjct: 662 NEDMFSPSE----LDTSKLSHKFK-ELQIKHAVTEAEIQKLK 698
Score = 52.0 bits (119), Expect = 6e-06
Identities = 29/86 (33%), Positives = 44/86 (51%), Gaps = 8/86 (9%)
Query: 13 VELTNDGNGLGFNLVGG--------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
VEL D +GLG +++G G+ +K V GG A +D R+Q D +++V ++
Sbjct: 505 VELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEVDGIS 564
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVAR 90
L G T A VLR VR ++ R
Sbjct: 565 LVGVTQNFAATVLRNTKGNVRFVIGR 590
Score = 46.8 bits (106), Expect = 2e-04
Identities = 30/94 (31%), Positives = 48/94 (51%), Gaps = 3/94 (3%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPN--GTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVS 610
V L K + GLG SI+ D I V+++ GG A+++G I D+++ V+G+S
Sbjct: 505 VELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEVDGIS 564
Query: 611 IQNATLDQAVQALKGAPRGTVKVGIARPLPPQDS 644
+ T + A L+ +G V+ I R P Q S
Sbjct: 565 LVGVTQNFAATVLRNT-KGNVRFVIGREKPGQVS 597
>AB033048-1|BAA86536.1| 742|Homo sapiens KIAA1222 protein protein.
Length = 742
Score = 76.6 bits (180), Expect = 3e-13
Identities = 61/222 (27%), Positives = 106/222 (47%), Gaps = 11/222 (4%)
Query: 177 DSVSPTITITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKE---ELSGIFVKSIIEG 233
D V+ + + + ++E+ V+L K+ GLGI++ G + E GIFVK++ EG
Sbjct: 127 DPVAASAEYELEKRVEKLELFPVELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEG 186
Query: 234 SSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHLQL 293
+A++ G+I++ND+I+EVDGISL + + +LRNT +V V+ R G E QL
Sbjct: 187 GAAQRDGRIQVNDQIVEVDGISLVGVTQNFAATVLRNTKGNVRFVIGREKPGQVSEVAQL 246
Query: 294 --AIFNEERXXXXXXXXXXLSWFPVPSQLENSITEIEPEPESNTTIDSSVLEVGDLQEPT 351
+ER + + T+ E E E + S + + + P
Sbjct: 247 ISQTLEQERRQRELLEQHYAQYDADDDETGEYATD-EEEDEVGPVLPGSDMAIEVFELPE 305
Query: 352 QEELDQRFDEILAVDKEDIVKKWKEEIGSDKEILVAEIKKLE 393
E++ + +D + K+K E+ + AEI+KL+
Sbjct: 306 NEDMFSPSE----LDTSKLSHKFK-ELQIKHAVTEAEIQKLK 342
Score = 52.0 bits (119), Expect = 6e-06
Identities = 29/86 (33%), Positives = 44/86 (51%), Gaps = 8/86 (9%)
Query: 13 VELTNDGNGLGFNLVGG--------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
VEL D +GLG +++G G+ +K V GG A +D R+Q D +++V ++
Sbjct: 149 VELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEVDGIS 208
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVAR 90
L G T A VLR VR ++ R
Sbjct: 209 LVGVTQNFAATVLRNTKGNVRFVIGR 234
Score = 46.8 bits (106), Expect = 2e-04
Identities = 30/94 (31%), Positives = 48/94 (51%), Gaps = 3/94 (3%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPN--GTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVS 610
V L K + GLG SI+ D I V+++ GG A+++G I D+++ V+G+S
Sbjct: 149 VELEKDEDGLGISIIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEVDGIS 208
Query: 611 IQNATLDQAVQALKGAPRGTVKVGIARPLPPQDS 644
+ T + A L+ +G V+ I R P Q S
Sbjct: 209 LVGVTQNFAATVLRNT-KGNVRFVIGREKPGQVS 241
>AF038563-1|AAC05370.1| 1455|Homo sapiens membrane associated
guanylate kinase 2 protein.
Length = 1455
Score = 75.8 bits (178), Expect = 5e-13
Identities = 147/631 (23%), Positives = 263/631 (41%), Gaps = 80/631 (12%)
Query: 15 LTNDGNGLGFNLVGGRSTG--VVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQ 72
L G GF ++GG + +K V+P G A +D ++++GD ++ + V + G T
Sbjct: 429 LKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHAD 488
Query: 73 VAAVLRQA--GPVVRLLVAR----PADPATALRAPQPGTALV--PTKILADPELLDRHLI 124
V + + G V L++ R P DP + P A++ P ++ + RH
Sbjct: 489 VVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVN----GRHNY 544
Query: 125 ETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQKIPDHPIVCDSVSPTIT 184
ET + SQ D I + + S+ + G P + D D+VS +
Sbjct: 545 ETYLEYISRTSQSVPD--ITDRPPHSLHSMPTDG-QLDGTYPPPVHD-----DNVSMASS 596
Query: 185 ITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKI 244
EL + I+ K G G T+A + +G VK I++ G +
Sbjct: 597 GATQAELMTLTIV-----KGAQGFGFTIA------DSPTGQRVKQILDIQGCP--GLCE- 642
Query: 245 NDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHLQLAIFNEERXXXX 304
D I+E++ ++ + S+ + V+IL++ I L + RG F + +R
Sbjct: 643 GDLIVEINQQNVQNLSHTEVVDILKDCPIGSETSLIIH-RGGFFSPWKTPKPIMDRWENQ 701
Query: 305 XXXXXXLSWFPVPSQLENSITEIEPEPESNTTIDSSVLEVGDLQEPTQEELDQRFDEILA 364
LS +P L P ++ DS+ E D ++P EL ++ I
Sbjct: 702 GSPQTSLSAPAIPQNLP-----FPPALHRSSFPDST--EAFDPRKPDPYELYEKSRAIYE 754
Query: 365 VDKEDIVKKWK---EEIGSDKEILVAEIKKLE-GLGISLEGTVDVEGGQELRPHHYIRSV 420
++ + + + G D + L ++++E G G + G E GQ + I +V
Sbjct: 755 -SRQQVPPRTSFRMDSSGPDYKELDVHLRRMESGFGFRILG--GDEPGQPI----LIGAV 807
Query: 421 LPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP--DRVRLVCARNSIDSGP 478
+ G G L+ GDEL+ V+ + G TH V++++ +V L R + G
Sbjct: 808 IAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGE 867
Query: 479 RPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLE 538
N S GS++ T +SD + T+S NH+ S + E
Sbjct: 868 PCPENGRSP-----------GSVS--THHSSPRSDYATYTNS-----NHAAPSSNASPPE 909
Query: 539 CVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIV---VRSLVPGGVAEKNG 595
+ ++ S D+V+ K ++G GF I+ + + T+ V + ++ G A++
Sbjct: 910 GFASHSLQTS--DVVIHRKENEGFGFVIISSLNRPESGSTITVXHKIGRIIDGSPADRCA 967
Query: 596 EISPGDRVMSVNGVSIQNATLDQAVQALKGA 626
++ GDR+++VNG SI N V+ +K A
Sbjct: 968 KLKVGDRILAVNGQSIINMPHADIVKLIKDA 998
Score = 62.5 bits (145), Expect = 5e-09
Identities = 111/487 (22%), Positives = 206/487 (42%), Gaps = 60/487 (12%)
Query: 201 LNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKS 260
L K+ G G T+ G E +E + VKS+I A Q GK++ D I+ ++ + + +
Sbjct: 429 LKKSNMGFGFTIIGGD-EPDEF--LQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHT 485
Query: 261 NPQSVEILRNT--GISVHLVLERYLRGPKFEHLQLAIFNEERXXXXXXXXXXLSWFPVPS 318
+ V++ ++ G SV+LVL R P F+ E + P P
Sbjct: 486 HADVVKLFQSVPIGQSVNLVLCRGYPLP---------FDPEDPANSMVPPLAIMERPPPV 536
Query: 319 QLENSITEIEPEPESNTTIDSSVLEVGDLQEPTQEEL--DQRFDEILAVDKEDIVKKWKE 376
+ N E E + SV ++ D + + D + D D
Sbjct: 537 MV-NGRHNYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMAS 595
Query: 377 EIGSDKEILVAEIKK-LEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAG 435
+ E++ I K +G G ++ D GQ ++ I+ G G+ G
Sbjct: 596 SGATQAELMTLTIVKGAQGFGFTI---ADSPTGQRVKQILDIQ--------GCPGLCE-G 643
Query: 436 DELLEVNEYRLHGLTHSEVVNILKQLP--DRVRLVCARNSIDSG---PRPVVNLASDREG 490
D ++E+N+ + L+H+EVV+ILK P L+ R S P+P+++ + +G
Sbjct: 644 DLIVEINQQNVQNLSHTEVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMD-RWENQG 702
Query: 491 FEARKIISGSLNNLTTLVKAQSDTSINTSSTA---TLTNHSEQSKKSRSL----ECV--- 540
+ + ++ A +S S+ A + E +KSR++ + V
Sbjct: 703 SPQTSLSAPAIPQNLPFPPALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPR 762
Query: 541 SGLAMWQS----KEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGE 596
+ M S KE V L + + G GF IL +P P I++ +++ G A+++G
Sbjct: 763 TSFRMDSSGPDYKELDVHLRRMESGFGFRILGGDEPGQP----ILIGAVIAMGSADRDGR 818
Query: 597 ISPGDRVMSVNGVSIQNATLDQAVQALKGAPR-GTVKVGIARPL-----PPQDSSKSKGT 650
+ PGD ++ V+G+ + T + + A R G V + + R + P ++ +S G+
Sbjct: 819 LHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGS 878
Query: 651 INVNKAS 657
++ + +S
Sbjct: 879 VSTHHSS 885
Score = 52.0 bits (119), Expect = 6e-06
Identities = 24/89 (26%), Positives = 53/89 (59%), Gaps = 3/89 (3%)
Query: 193 EIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVD 252
+ + VD+ K G G ++ G +E ++V + E A ++G++++ D+IIE++
Sbjct: 1142 DFDYFTVDMEKGAKGFGFSIRG---GREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEIN 1198
Query: 253 GISLADKSNPQSVEILRNTGISVHLVLER 281
G S D ++ +++E++++ G V L+L+R
Sbjct: 1199 GESTRDMTHARAIELIKSGGRRVRLLLKR 1227
Score = 47.6 bits (108), Expect = 1e-04
Identities = 20/69 (28%), Positives = 37/69 (53%)
Query: 405 VEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDR 464
+ GG+E + Y+ + DGP G + GD+++E+N +TH+ + ++K R
Sbjct: 1161 IRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKSGGRR 1220
Query: 465 VRLVCARNS 473
VRL+ R +
Sbjct: 1221 VRLLLKRGT 1229
Score = 42.7 bits (96), Expect = 0.004
Identities = 18/48 (37%), Positives = 34/48 (70%)
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHL 277
II+GS A++ K+K+ DRI+ V+G S+ + + V+++++ G+SV L
Sbjct: 957 IIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTL 1004
Score = 41.5 bits (93), Expect = 0.009
Identities = 25/94 (26%), Positives = 45/94 (47%), Gaps = 4/94 (4%)
Query: 13 VELTNDGNGLGFNLVGGRSTGVVIKYVL---PGGVADKDRRLQSGDHVLQVGSVNLRGFT 69
V++ G GF++ GGR + + YVL G A ++ R++ GD ++++ + R T
Sbjct: 1148 VDMEKGAKGFGFSIRGGREYKMDL-YVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMT 1206
Query: 70 SEQVAAVLRQAGPVVRLLVARPADPATALRAPQP 103
+ +++ G VRLL+ R P P
Sbjct: 1207 HARAIELIKSGGRRVRLLLKRGTGQVPQYDEPAP 1240
Score = 40.7 bits (91), Expect = 0.016
Identities = 23/70 (32%), Positives = 36/70 (51%), Gaps = 2/70 (2%)
Query: 13 VELTNDGNGLGFNLVGGRSTG--VVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTS 70
V L +G GF ++GG G ++I V+ G AD+D RL GD ++ V + + G T
Sbjct: 779 VHLRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTH 838
Query: 71 EQVAAVLRQA 80
V ++ A
Sbjct: 839 RYVIDLMHHA 848
Score = 39.1 bits (87), Expect = 0.049
Identities = 30/95 (31%), Positives = 47/95 (49%), Gaps = 5/95 (5%)
Query: 395 LGISLEGTV--DVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELL-EVNEYRLHGLTH 451
+G + EG + +++GG E Y+ V P G +ELL EVNE + GLT
Sbjct: 20 IGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKLVSEELLLEVNETPVAGLTI 79
Query: 452 SEVVNILKQLPDRVRLVCARNS--IDSGPRPVVNL 484
+V+ ++K D +RL C + +D R +NL
Sbjct: 80 RDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNL 114
Score = 35.5 bits (78), Expect = 0.60
Identities = 23/77 (29%), Positives = 41/77 (53%), Gaps = 6/77 (7%)
Query: 553 VMLVKADQGLGFSILDYQD-PVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSI 611
V + K +G GFSI ++ +D + V L G A +NG + GD+++ +NG S
Sbjct: 1148 VDMEKGAKGFGFSIRGGREYKMD-----LYVLRLAEDGPAIRNGRMRVGDQIIEINGEST 1202
Query: 612 QNATLDQAVQALKGAPR 628
++ T +A++ +K R
Sbjct: 1203 RDMTHARAIELIKSGGR 1219
>U83192-1|AAC52113.1| 767|Homo sapiens post-synaptic density
protein 95 protein.
Length = 767
Score = 74.5 bits (175), Expect = 1e-12
Identities = 72/275 (26%), Positives = 125/275 (45%), Gaps = 26/275 (9%)
Query: 380 SDKEILVAEIKKLEGLGISLEGTVDVEGGQELRPHH--YIRSVLPDGPVGLQGVLNAGDE 437
++K + + IK +GLG S+ G V G Q + + Y+ ++ G G L GD+
Sbjct: 198 AEKVMEIKLIKGPKGLGFSIAGGV---GNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDK 254
Query: 438 LLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKII 497
+L VN L + H + V LK D V L A+ P SD + I
Sbjct: 255 ILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAK--------PSNAYLSD--SYAPPDIT 304
Query: 498 SGSLNNLTTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVK 557
+ +L + S + + T T+ S ++ L + + +++ +
Sbjct: 305 TSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRR---IVIHR 361
Query: 558 ADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLD 617
GLGF+I+ +D G I + ++ GG A+ +GE+ GD+++SVNGV ++NA+ +
Sbjct: 362 GSTGLGFNIVGGED-----GEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHE 416
Query: 618 QAVQALKGAPRGTVKVGIARPLPPQDSSKSKGTIN 652
QA ALK A + V I P++ S+ + I+
Sbjct: 417 QAAIALKNAGQ---TVTIIAQYKPEEYSRFEAKIH 448
Score = 62.9 bits (146), Expect = 3e-09
Identities = 30/68 (44%), Positives = 41/68 (60%), Gaps = 1/68 (1%)
Query: 21 GLGFNLVGGRS-TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAVLRQ 79
GLGFN+VGG G+ I ++L GG AD L+ GD +L V V+LR + EQ A L+
Sbjct: 365 GLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKN 424
Query: 80 AGPVVRLL 87
AG V ++
Sbjct: 425 AGQTVTII 432
Score = 58.0 bits (134), Expect = 1e-07
Identities = 32/94 (34%), Positives = 48/94 (51%), Gaps = 7/94 (7%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRST-------GVVIKYVLPGGVADKDRRLQSGDHVLQVG 61
+ E + L +GLGF++ GG + I ++PGG A +D RL+ D +L V
Sbjct: 105 EYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVN 164
Query: 62 SVNLRGFTSEQVAAVLRQAGPVVRLLVARPADPA 95
V++R T L++AG +VRL V R PA
Sbjct: 165 EVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPA 198
Score = 54.8 bits (126), Expect = 9e-07
Identities = 32/92 (34%), Positives = 46/92 (50%), Gaps = 7/92 (7%)
Query: 9 QVEVVELTNDGNGLGFNLVGG-------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVG 61
+V ++L GLGF++ GG + + ++ GG A KD RLQ GD +L V
Sbjct: 200 KVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVN 259
Query: 62 SVNLRGFTSEQVAAVLRQAGPVVRLLVARPAD 93
SV L E A L+ VV L VA+P++
Sbjct: 260 SVGLEDVMHEDAVAALKNTYDVVYLKVAKPSN 291
Score = 53.6 bits (123), Expect = 2e-06
Identities = 30/89 (33%), Positives = 52/89 (58%), Gaps = 4/89 (4%)
Query: 192 PEIEIIHVDLNKNVYGLGITVAGYVCEKEELSG---IFVKSIIEGSSAEQSGKIKINDRI 248
P +++ + L K GLG ++AG V + + G I+V IIEG +A + G+++I D+I
Sbjct: 197 PAEKVMEIKLIKGPKGLGFSIAGGV-GNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKI 255
Query: 249 IEVDGISLADKSNPQSVEILRNTGISVHL 277
+ V+ + L D + +V L+NT V+L
Sbjct: 256 LAVNSVGLEDVMHEDAVAALKNTYDVVYL 284
Score = 52.0 bits (119), Expect = 6e-06
Identities = 30/92 (32%), Positives = 49/92 (53%), Gaps = 2/92 (2%)
Query: 553 VMLVKADQGLGFSILDYQD-PVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSI 611
+ L + + GLGFSI D P + I + ++PGG A ++G + D ++ VN V +
Sbjct: 109 ITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDV 168
Query: 612 QNATLDQAVQALKGAPRGTVKVGIARPLPPQD 643
+ T AV+ALK A V++ + R PP +
Sbjct: 169 REVTHSAAVEALKEA-GSIVRLYVMRRKPPAE 199
Score = 51.2 bits (117), Expect = 1e-05
Identities = 32/111 (28%), Positives = 57/111 (51%), Gaps = 1/111 (0%)
Query: 171 DHPIVCDSVSPTITITVPVELPEIEIIHVDLNKNVYGLGITVAGY-VCEKEELSGIFVKS 229
D+P SP V +L E I + + V G T G+ + E+ GIF+
Sbjct: 324 DYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISF 383
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLE 280
I+ G A+ SG+++ D+I+ V+G+ L + S+ Q+ L+N G +V ++ +
Sbjct: 384 ILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQ 434
Score = 50.0 bits (114), Expect = 3e-05
Identities = 27/91 (29%), Positives = 49/91 (53%), Gaps = 2/91 (2%)
Query: 193 EIEIIHVDLNKNVYGLGITVAGYVCEKE--ELSGIFVKSIIEGSSAEQSGKIKINDRIIE 250
E+E + L + GLG ++AG + IF+ II G +A Q G++++ND I+
Sbjct: 103 EMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILF 162
Query: 251 VDGISLADKSNPQSVEILRNTGISVHLVLER 281
V+ + + + ++ +VE L+ G V L + R
Sbjct: 163 VNEVDVREVTHSAAVEALKEAGSIVRLYVMR 193
Score = 44.0 bits (99), Expect = 0.002
Identities = 28/79 (35%), Positives = 37/79 (46%), Gaps = 3/79 (3%)
Query: 394 GLGISLEGTVDVEG-GQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHS 452
GLG S+ G D G + P +I ++P G G L D +L VNE + +THS
Sbjct: 117 GLGFSIAGGTDNPHIGDD--PSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHS 174
Query: 453 EVVNILKQLPDRVRLVCAR 471
V LK+ VRL R
Sbjct: 175 AAVEALKEAGSIVRLYVMR 193
>AF156495-1|AAD56173.1| 767|Homo sapiens post-synaptic density 95
protein.
Length = 767
Score = 74.5 bits (175), Expect = 1e-12
Identities = 72/275 (26%), Positives = 125/275 (45%), Gaps = 26/275 (9%)
Query: 380 SDKEILVAEIKKLEGLGISLEGTVDVEGGQELRPHH--YIRSVLPDGPVGLQGVLNAGDE 437
++K + + IK +GLG S+ G V G Q + + Y+ ++ G G L GD+
Sbjct: 198 AEKVMEIKLIKGPKGLGFSIAGGV---GNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDK 254
Query: 438 LLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKII 497
+L VN L + H + V LK D V L A+ P SD + I
Sbjct: 255 ILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAK--------PSNAYLSD--SYAPPDIT 304
Query: 498 SGSLNNLTTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVK 557
+ +L + S + + T T+ S ++ L + + +++ +
Sbjct: 305 TSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRR---IVIHR 361
Query: 558 ADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLD 617
GLGF+I+ +D G I + ++ GG A+ +GE+ GD+++SVNGV ++NA+ +
Sbjct: 362 GSTGLGFNIVGGED-----GEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHE 416
Query: 618 QAVQALKGAPRGTVKVGIARPLPPQDSSKSKGTIN 652
QA ALK A + V I P++ S+ + I+
Sbjct: 417 QAAIALKNAGQ---TVTIIAQYKPEEYSRFEAKIH 448
Score = 62.9 bits (146), Expect = 3e-09
Identities = 30/68 (44%), Positives = 41/68 (60%), Gaps = 1/68 (1%)
Query: 21 GLGFNLVGGRS-TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAVLRQ 79
GLGFN+VGG G+ I ++L GG AD L+ GD +L V V+LR + EQ A L+
Sbjct: 365 GLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKN 424
Query: 80 AGPVVRLL 87
AG V ++
Sbjct: 425 AGQTVTII 432
Score = 58.0 bits (134), Expect = 1e-07
Identities = 32/94 (34%), Positives = 48/94 (51%), Gaps = 7/94 (7%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRST-------GVVIKYVLPGGVADKDRRLQSGDHVLQVG 61
+ E + L +GLGF++ GG + I ++PGG A +D RL+ D +L V
Sbjct: 105 EYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVN 164
Query: 62 SVNLRGFTSEQVAAVLRQAGPVVRLLVARPADPA 95
V++R T L++AG +VRL V R PA
Sbjct: 165 EVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPA 198
Score = 54.8 bits (126), Expect = 9e-07
Identities = 32/92 (34%), Positives = 46/92 (50%), Gaps = 7/92 (7%)
Query: 9 QVEVVELTNDGNGLGFNLVGG-------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVG 61
+V ++L GLGF++ GG + + ++ GG A KD RLQ GD +L V
Sbjct: 200 KVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVN 259
Query: 62 SVNLRGFTSEQVAAVLRQAGPVVRLLVARPAD 93
SV L E A L+ VV L VA+P++
Sbjct: 260 SVGLEDVMHEDAVAALKNTYDVVYLKVAKPSN 291
Score = 53.6 bits (123), Expect = 2e-06
Identities = 30/89 (33%), Positives = 52/89 (58%), Gaps = 4/89 (4%)
Query: 192 PEIEIIHVDLNKNVYGLGITVAGYVCEKEELSG---IFVKSIIEGSSAEQSGKIKINDRI 248
P +++ + L K GLG ++AG V + + G I+V IIEG +A + G+++I D+I
Sbjct: 197 PAEKVMEIKLIKGPKGLGFSIAGGV-GNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKI 255
Query: 249 IEVDGISLADKSNPQSVEILRNTGISVHL 277
+ V+ + L D + +V L+NT V+L
Sbjct: 256 LAVNSVGLEDVMHEDAVAALKNTYDVVYL 284
Score = 52.0 bits (119), Expect = 6e-06
Identities = 30/92 (32%), Positives = 49/92 (53%), Gaps = 2/92 (2%)
Query: 553 VMLVKADQGLGFSILDYQD-PVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSI 611
+ L + + GLGFSI D P + I + ++PGG A ++G + D ++ VN V +
Sbjct: 109 ITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDV 168
Query: 612 QNATLDQAVQALKGAPRGTVKVGIARPLPPQD 643
+ T AV+ALK A V++ + R PP +
Sbjct: 169 REVTHSAAVEALKEA-GSIVRLYVMRRKPPAE 199
Score = 51.2 bits (117), Expect = 1e-05
Identities = 32/111 (28%), Positives = 57/111 (51%), Gaps = 1/111 (0%)
Query: 171 DHPIVCDSVSPTITITVPVELPEIEIIHVDLNKNVYGLGITVAGY-VCEKEELSGIFVKS 229
D+P SP V +L E I + + V G T G+ + E+ GIF+
Sbjct: 324 DYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISF 383
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLE 280
I+ G A+ SG+++ D+I+ V+G+ L + S+ Q+ L+N G +V ++ +
Sbjct: 384 ILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQ 434
Score = 50.0 bits (114), Expect = 3e-05
Identities = 27/91 (29%), Positives = 49/91 (53%), Gaps = 2/91 (2%)
Query: 193 EIEIIHVDLNKNVYGLGITVAGYVCEKE--ELSGIFVKSIIEGSSAEQSGKIKINDRIIE 250
E+E + L + GLG ++AG + IF+ II G +A Q G++++ND I+
Sbjct: 103 EMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILF 162
Query: 251 VDGISLADKSNPQSVEILRNTGISVHLVLER 281
V+ + + + ++ +VE L+ G V L + R
Sbjct: 163 VNEVDVREVTHSAAVEALKEAGSIVRLYVMR 193
Score = 44.0 bits (99), Expect = 0.002
Identities = 28/79 (35%), Positives = 37/79 (46%), Gaps = 3/79 (3%)
Query: 394 GLGISLEGTVDVEG-GQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHS 452
GLG S+ G D G + P +I ++P G G L D +L VNE + +THS
Sbjct: 117 GLGFSIAGGTDNPHIGDD--PSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHS 174
Query: 453 EVVNILKQLPDRVRLVCAR 471
V LK+ VRL R
Sbjct: 175 AAVEALKEAGSIVRLYVMR 193
>BC071566-1|AAH71566.1| 1340|Homo sapiens PARD3 protein protein.
Length = 1340
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 272 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 332 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 391
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 392 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 442
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 443 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 502
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 503 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 534
Score = 60.1 bits (139), Expect = 2e-08
Identities = 37/102 (36%), Positives = 57/102 (55%), Gaps = 3/102 (2%)
Query: 172 HPIVCDSVSPTITITVPVELPEIEIIHVDLNKN-VYGLGITVAGYVCEKEELS-GIFVKS 229
HP + I +T P E V LN + GLG++V G ++ GIFVKS
Sbjct: 552 HPRELKAEDEDIVLT-PDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKS 610
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
II G +A + G++++ND++I V+G SL K+N ++E LR +
Sbjct: 611 IINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRS 652
Score = 51.6 bits (118), Expect = 9e-06
Identities = 31/88 (35%), Positives = 50/88 (56%), Gaps = 7/88 (7%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 462 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPAD 93
+ E+V ++LR + V LLV R D
Sbjct: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQED 549
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 462 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 521 GKSQEEVVSLLRSTKMEGTVSLLVFR 546
Score = 48.4 bits (110), Expect = 8e-05
Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 16/131 (12%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 578 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 637
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 638 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 697
Query: 117 ELLDRHLIETG 127
E H + +G
Sbjct: 698 ERRISHSLYSG 708
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 587 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 646
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 647 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 682
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 466 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 522
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 523 SQEEVVSLLR 532
>AL450337-8|CAI15041.1| 988|Homo sapiens par-3 partitioning
defective 3 homolog (C. elegans) protein.
Length = 988
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 272 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 332 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 391
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 392 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 442
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 443 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 502
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 503 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 534
Score = 60.1 bits (139), Expect = 2e-08
Identities = 37/102 (36%), Positives = 57/102 (55%), Gaps = 3/102 (2%)
Query: 172 HPIVCDSVSPTITITVPVELPEIEIIHVDLNKN-VYGLGITVAGYVCEKEELS-GIFVKS 229
HP + I +T P E V LN + GLG++V G ++ GIFVKS
Sbjct: 552 HPRELKAEDEDIVLT-PDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKS 610
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
II G +A + G++++ND++I V+G SL K+N ++E LR +
Sbjct: 611 IINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRS 652
Score = 51.6 bits (118), Expect = 9e-06
Identities = 31/88 (35%), Positives = 50/88 (56%), Gaps = 7/88 (7%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 462 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPAD 93
+ E+V ++LR + V LLV R D
Sbjct: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQED 549
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 462 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 521 GKSQEEVVSLLRSTKMEGTVSLLVFR 546
Score = 48.4 bits (110), Expect = 8e-05
Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 16/131 (12%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 578 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 637
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 638 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 697
Query: 117 ELLDRHLIETG 127
E H + +G
Sbjct: 698 ERRISHSLYSG 708
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 587 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 646
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 647 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 682
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 466 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 522
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 523 SQEEVVSLLR 532
>AL450337-7|CAI15042.1| 1001|Homo sapiens par-3 partitioning
defective 3 homolog (C. elegans) protein.
Length = 1001
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 272 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 332 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 391
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 392 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 442
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 443 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 502
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 503 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 534
Score = 58.8 bits (136), Expect = 6e-08
Identities = 28/66 (42%), Positives = 45/66 (68%), Gaps = 1/66 (1%)
Query: 207 GLGITVAGYVCEKEELS-GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSV 265
GLG++V G ++ GIFVKSII G +A + G++++ND++I V+G SL K+N ++
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 266 EILRNT 271
E LR +
Sbjct: 660 ETLRRS 665
Score = 52.4 bits (120), Expect = 5e-06
Identities = 37/114 (32%), Positives = 60/114 (52%), Gaps = 10/114 (8%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 462 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPADP--ATALRAPQPGTALVPTKILADPE 117
+ E+V ++LR + V LLV R D L A +P +P + A+ E
Sbjct: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNA-EPSQMQIPKETKAEDE 574
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 462 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 521 GKSQEEVVSLLRSTKMEGTVSLLVFR 546
Score = 48.4 bits (110), Expect = 8e-05
Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 16/131 (12%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 591 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 650
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 651 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 710
Query: 117 ELLDRHLIETG 127
E H + +G
Sbjct: 711 ERRISHSLYSG 721
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 660 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 695
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 466 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 522
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 523 SQEEVVSLLR 532
>AL450337-6|CAI15038.1| 1244|Homo sapiens par-3 partitioning
defective 3 homolog (C. elegans) protein.
Length = 1244
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 228 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 287
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 288 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 347
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 348 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 398
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 399 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 458
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 459 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 490
Score = 60.1 bits (139), Expect = 2e-08
Identities = 37/102 (36%), Positives = 57/102 (55%), Gaps = 3/102 (2%)
Query: 172 HPIVCDSVSPTITITVPVELPEIEIIHVDLNKN-VYGLGITVAGYVCEKEELS-GIFVKS 229
HP + I +T P E V LN + GLG++V G ++ GIFVKS
Sbjct: 508 HPRELKAEDEDIVLT-PDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKS 566
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
II G +A + G++++ND++I V+G SL K+N ++E LR +
Sbjct: 567 IINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRS 608
Score = 51.6 bits (118), Expect = 9e-06
Identities = 31/88 (35%), Positives = 50/88 (56%), Gaps = 7/88 (7%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 418 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 477
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPAD 93
+ E+V ++LR + V LLV R D
Sbjct: 478 KSQEEVVSLLRSTKMEGTVSLLVFRQED 505
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 418 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 476
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 477 GKSQEEVVSLLRSTKMEGTVSLLVFR 502
Score = 48.4 bits (110), Expect = 8e-05
Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 16/131 (12%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 534 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 593
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 594 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 653
Query: 117 ELLDRHLIETG 127
E H + +G
Sbjct: 654 ERRISHSLYSG 664
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 543 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 602
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 603 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 638
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 422 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 478
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 479 SQEEVVSLLR 488
>AL450337-5|CAI15037.1| 1319|Homo sapiens par-3 partitioning
defective 3 homolog (C. elegans) protein.
Length = 1319
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 272 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 332 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 391
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 392 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 442
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 443 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 502
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 503 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 534
Score = 58.8 bits (136), Expect = 6e-08
Identities = 28/66 (42%), Positives = 45/66 (68%), Gaps = 1/66 (1%)
Query: 207 GLGITVAGYVCEKEELS-GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSV 265
GLG++V G ++ GIFVKSII G +A + G++++ND++I V+G SL K+N ++
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 266 EILRNT 271
E LR +
Sbjct: 660 ETLRRS 665
Score = 52.4 bits (120), Expect = 5e-06
Identities = 37/114 (32%), Positives = 60/114 (52%), Gaps = 10/114 (8%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 462 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPADP--ATALRAPQPGTALVPTKILADPE 117
+ E+V ++LR + V LLV R D L A +P +P + A+ E
Sbjct: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNA-EPSQMQIPKETKAEDE 574
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 462 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 521 GKSQEEVVSLLRSTKMEGTVSLLVFR 546
Score = 48.8 bits (111), Expect = 6e-05
Identities = 45/158 (28%), Positives = 75/158 (47%), Gaps = 17/158 (10%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 591 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 650
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 651 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 710
Query: 117 ELLDRHLIETGY-GAVYDLSQCYSDYNINGQNGETETS 153
E H + +G G S+ + I G++G+ + S
Sbjct: 711 ERRISHSLYSGIEGLDESPSRNAALSRIMGESGKYQLS 748
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 660 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 695
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 466 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 522
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 523 SQEEVVSLLR 532
>AL450337-4|CAI15040.1| 1353|Homo sapiens par-3 partitioning
defective 3 homolog (C. elegans) protein.
Length = 1353
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 272 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 332 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 391
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 392 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 442
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 443 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 502
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 503 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 534
Score = 58.8 bits (136), Expect = 6e-08
Identities = 28/66 (42%), Positives = 45/66 (68%), Gaps = 1/66 (1%)
Query: 207 GLGITVAGYVCEKEELS-GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSV 265
GLG++V G ++ GIFVKSII G +A + G++++ND++I V+G SL K+N ++
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 266 EILRNT 271
E LR +
Sbjct: 660 ETLRRS 665
Score = 52.4 bits (120), Expect = 5e-06
Identities = 37/114 (32%), Positives = 60/114 (52%), Gaps = 10/114 (8%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 462 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPADP--ATALRAPQPGTALVPTKILADPE 117
+ E+V ++LR + V LLV R D L A +P +P + A+ E
Sbjct: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNA-EPSQMQIPKETKAEDE 574
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 462 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 521 GKSQEEVVSLLRSTKMEGTVSLLVFR 546
Score = 48.4 bits (110), Expect = 8e-05
Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 16/131 (12%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 591 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 650
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 651 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 710
Query: 117 ELLDRHLIETG 127
E H + +G
Sbjct: 711 ERRISHSLYSG 721
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 660 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 695
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 466 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 522
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 523 SQEEVVSLLR 532
>AL450337-3|CAI15039.1| 1356|Homo sapiens par-3 partitioning
defective 3 homolog (C. elegans) protein.
Length = 1356
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 272 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 332 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 391
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 392 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 442
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 443 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 502
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 503 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 534
Score = 58.8 bits (136), Expect = 6e-08
Identities = 28/66 (42%), Positives = 45/66 (68%), Gaps = 1/66 (1%)
Query: 207 GLGITVAGYVCEKEELS-GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSV 265
GLG++V G ++ GIFVKSII G +A + G++++ND++I V+G SL K+N ++
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 266 EILRNT 271
E LR +
Sbjct: 660 ETLRRS 665
Score = 52.4 bits (120), Expect = 5e-06
Identities = 37/114 (32%), Positives = 60/114 (52%), Gaps = 10/114 (8%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 462 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPADP--ATALRAPQPGTALVPTKILADPE 117
+ E+V ++LR + V LLV R D L A +P +P + A+ E
Sbjct: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNA-EPSQMQIPKETKAEDE 574
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 462 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 521 GKSQEEVVSLLRSTKMEGTVSLLVFR 546
Score = 48.8 bits (111), Expect = 6e-05
Identities = 45/158 (28%), Positives = 75/158 (47%), Gaps = 17/158 (10%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 591 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 650
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 651 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 710
Query: 117 ELLDRHLIETGY-GAVYDLSQCYSDYNINGQNGETETS 153
E H + +G G S+ + I G++G+ + S
Sbjct: 711 ERRISHSLYSGIEGLDESPSRNAALSRIMGESGKYQLS 748
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 660 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 695
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 466 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 522
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 523 SQEEVVSLLR 532
>AL450337-2|CAI15035.1| 1296|Homo sapiens par-3 partitioning
defective 3 homolog (C. elegans) protein.
Length = 1296
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 228 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 287
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 288 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 347
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 348 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 398
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 399 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 458
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 459 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 490
Score = 60.1 bits (139), Expect = 2e-08
Identities = 37/102 (36%), Positives = 57/102 (55%), Gaps = 3/102 (2%)
Query: 172 HPIVCDSVSPTITITVPVELPEIEIIHVDLNKN-VYGLGITVAGYVCEKEELS-GIFVKS 229
HP + I +T P E V LN + GLG++V G ++ GIFVKS
Sbjct: 508 HPRELKAEDEDIVLT-PDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKS 566
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
II G +A + G++++ND++I V+G SL K+N ++E LR +
Sbjct: 567 IINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRS 608
Score = 51.6 bits (118), Expect = 9e-06
Identities = 31/88 (35%), Positives = 50/88 (56%), Gaps = 7/88 (7%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 418 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 477
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPAD 93
+ E+V ++LR + V LLV R D
Sbjct: 478 KSQEEVVSLLRSTKMEGTVSLLVFRQED 505
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 418 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 476
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 477 GKSQEEVVSLLRSTKMEGTVSLLVFR 502
Score = 48.4 bits (110), Expect = 8e-05
Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 16/131 (12%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 534 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 593
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 594 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 653
Query: 117 ELLDRHLIETG 127
E H + +G
Sbjct: 654 ERRISHSLYSG 664
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 543 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 602
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 603 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 638
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 422 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 478
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 479 SQEEVVSLLR 488
>AL450337-1|CAI15036.1| 1310|Homo sapiens par-3 partitioning
defective 3 homolog (C. elegans) protein.
Length = 1310
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 272 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 332 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 391
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 392 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 442
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 443 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 502
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 503 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 534
Score = 60.1 bits (139), Expect = 2e-08
Identities = 37/102 (36%), Positives = 57/102 (55%), Gaps = 3/102 (2%)
Query: 172 HPIVCDSVSPTITITVPVELPEIEIIHVDLNKN-VYGLGITVAGYVCEKEELS-GIFVKS 229
HP + I +T P E V LN + GLG++V G ++ GIFVKS
Sbjct: 552 HPRELKAEDEDIVLT-PDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKS 610
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
II G +A + G++++ND++I V+G SL K+N ++E LR +
Sbjct: 611 IINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRS 652
Score = 51.6 bits (118), Expect = 9e-06
Identities = 31/88 (35%), Positives = 50/88 (56%), Gaps = 7/88 (7%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 462 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPAD 93
+ E+V ++LR + V LLV R D
Sbjct: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQED 549
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 462 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 521 GKSQEEVVSLLRSTKMEGTVSLLVFR 546
Score = 48.4 bits (110), Expect = 8e-05
Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 16/131 (12%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 578 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 637
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 638 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 697
Query: 117 ELLDRHLIETG 127
E H + +G
Sbjct: 698 ERRISHSLYSG 708
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 587 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 646
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 647 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 682
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 466 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 522
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 523 SQEEVVSLLR 532
>AL392123-8|CAI17334.1| 1001|Homo sapiens par-3 partitioning
defective 3 homolog (C. elegans) protein.
Length = 1001
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 272 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 332 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 391
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 392 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 442
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 443 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 502
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 503 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 534
Score = 58.8 bits (136), Expect = 6e-08
Identities = 28/66 (42%), Positives = 45/66 (68%), Gaps = 1/66 (1%)
Query: 207 GLGITVAGYVCEKEELS-GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSV 265
GLG++V G ++ GIFVKSII G +A + G++++ND++I V+G SL K+N ++
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 266 EILRNT 271
E LR +
Sbjct: 660 ETLRRS 665
Score = 52.4 bits (120), Expect = 5e-06
Identities = 37/114 (32%), Positives = 60/114 (52%), Gaps = 10/114 (8%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 462 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPADP--ATALRAPQPGTALVPTKILADPE 117
+ E+V ++LR + V LLV R D L A +P +P + A+ E
Sbjct: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNA-EPSQMQIPKETKAEDE 574
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 462 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 521 GKSQEEVVSLLRSTKMEGTVSLLVFR 546
Score = 48.4 bits (110), Expect = 8e-05
Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 16/131 (12%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 591 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 650
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 651 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 710
Query: 117 ELLDRHLIETG 127
E H + +G
Sbjct: 711 ERRISHSLYSG 721
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 660 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 695
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 466 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 522
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 523 SQEEVVSLLR 532
>AL392123-7|CAI17333.1| 988|Homo sapiens par-3 partitioning
defective 3 homolog (C. elegans) protein.
Length = 988
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 272 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 332 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 391
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 392 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 442
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 443 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 502
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 503 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 534
Score = 60.1 bits (139), Expect = 2e-08
Identities = 37/102 (36%), Positives = 57/102 (55%), Gaps = 3/102 (2%)
Query: 172 HPIVCDSVSPTITITVPVELPEIEIIHVDLNKN-VYGLGITVAGYVCEKEELS-GIFVKS 229
HP + I +T P E V LN + GLG++V G ++ GIFVKS
Sbjct: 552 HPRELKAEDEDIVLT-PDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKS 610
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
II G +A + G++++ND++I V+G SL K+N ++E LR +
Sbjct: 611 IINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRS 652
Score = 51.6 bits (118), Expect = 9e-06
Identities = 31/88 (35%), Positives = 50/88 (56%), Gaps = 7/88 (7%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 462 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPAD 93
+ E+V ++LR + V LLV R D
Sbjct: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQED 549
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 462 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 521 GKSQEEVVSLLRSTKMEGTVSLLVFR 546
Score = 48.4 bits (110), Expect = 8e-05
Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 16/131 (12%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 578 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 637
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 638 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 697
Query: 117 ELLDRHLIETG 127
E H + +G
Sbjct: 698 ERRISHSLYSG 708
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 587 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 646
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 647 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 682
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 466 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 522
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 523 SQEEVVSLLR 532
>AL392123-6|CAI17330.1| 1296|Homo sapiens par-3 partitioning
defective 3 homolog (C. elegans) protein.
Length = 1296
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 228 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 287
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 288 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 347
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 348 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 398
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 399 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 458
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 459 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 490
Score = 60.1 bits (139), Expect = 2e-08
Identities = 37/102 (36%), Positives = 57/102 (55%), Gaps = 3/102 (2%)
Query: 172 HPIVCDSVSPTITITVPVELPEIEIIHVDLNKN-VYGLGITVAGYVCEKEELS-GIFVKS 229
HP + I +T P E V LN + GLG++V G ++ GIFVKS
Sbjct: 508 HPRELKAEDEDIVLT-PDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKS 566
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
II G +A + G++++ND++I V+G SL K+N ++E LR +
Sbjct: 567 IINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRS 608
Score = 51.6 bits (118), Expect = 9e-06
Identities = 31/88 (35%), Positives = 50/88 (56%), Gaps = 7/88 (7%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 418 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 477
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPAD 93
+ E+V ++LR + V LLV R D
Sbjct: 478 KSQEEVVSLLRSTKMEGTVSLLVFRQED 505
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 418 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 476
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 477 GKSQEEVVSLLRSTKMEGTVSLLVFR 502
Score = 48.4 bits (110), Expect = 8e-05
Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 16/131 (12%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 534 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 593
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 594 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 653
Query: 117 ELLDRHLIETG 127
E H + +G
Sbjct: 654 ERRISHSLYSG 664
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 543 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 602
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 603 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 638
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 422 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 478
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 479 SQEEVVSLLR 488
>AL392123-5|CAI17329.1| 1310|Homo sapiens par-3 partitioning
defective 3 homolog (C. elegans) protein.
Length = 1310
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 272 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 332 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 391
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 392 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 442
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 443 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 502
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 503 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 534
Score = 60.1 bits (139), Expect = 2e-08
Identities = 37/102 (36%), Positives = 57/102 (55%), Gaps = 3/102 (2%)
Query: 172 HPIVCDSVSPTITITVPVELPEIEIIHVDLNKN-VYGLGITVAGYVCEKEELS-GIFVKS 229
HP + I +T P E V LN + GLG++V G ++ GIFVKS
Sbjct: 552 HPRELKAEDEDIVLT-PDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKS 610
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
II G +A + G++++ND++I V+G SL K+N ++E LR +
Sbjct: 611 IINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRS 652
Score = 51.6 bits (118), Expect = 9e-06
Identities = 31/88 (35%), Positives = 50/88 (56%), Gaps = 7/88 (7%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 462 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPAD 93
+ E+V ++LR + V LLV R D
Sbjct: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQED 549
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 462 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 521 GKSQEEVVSLLRSTKMEGTVSLLVFR 546
Score = 48.4 bits (110), Expect = 8e-05
Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 16/131 (12%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 578 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 637
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 638 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 697
Query: 117 ELLDRHLIETG 127
E H + +G
Sbjct: 698 ERRISHSLYSG 708
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 587 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 646
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 647 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 682
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 466 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 522
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 523 SQEEVVSLLR 532
>AL392123-4|CAI17328.1| 1244|Homo sapiens par-3 partitioning
defective 3 homolog (C. elegans) protein.
Length = 1244
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 228 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 287
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 288 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 347
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 348 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 398
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 399 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 458
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 459 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 490
Score = 60.1 bits (139), Expect = 2e-08
Identities = 37/102 (36%), Positives = 57/102 (55%), Gaps = 3/102 (2%)
Query: 172 HPIVCDSVSPTITITVPVELPEIEIIHVDLNKN-VYGLGITVAGYVCEKEELS-GIFVKS 229
HP + I +T P E V LN + GLG++V G ++ GIFVKS
Sbjct: 508 HPRELKAEDEDIVLT-PDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKS 566
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
II G +A + G++++ND++I V+G SL K+N ++E LR +
Sbjct: 567 IINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRS 608
Score = 51.6 bits (118), Expect = 9e-06
Identities = 31/88 (35%), Positives = 50/88 (56%), Gaps = 7/88 (7%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 418 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 477
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPAD 93
+ E+V ++LR + V LLV R D
Sbjct: 478 KSQEEVVSLLRSTKMEGTVSLLVFRQED 505
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 418 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 476
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 477 GKSQEEVVSLLRSTKMEGTVSLLVFR 502
Score = 48.4 bits (110), Expect = 8e-05
Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 16/131 (12%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 534 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 593
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 594 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 653
Query: 117 ELLDRHLIETG 127
E H + +G
Sbjct: 654 ERRISHSLYSG 664
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 543 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 602
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 603 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 638
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 422 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 478
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 479 SQEEVVSLLR 488
>AL392123-3|CAI17327.1| 1319|Homo sapiens par-3 partitioning
defective 3 homolog (C. elegans) protein.
Length = 1319
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 272 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 332 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 391
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 392 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 442
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 443 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 502
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 503 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 534
Score = 58.8 bits (136), Expect = 6e-08
Identities = 28/66 (42%), Positives = 45/66 (68%), Gaps = 1/66 (1%)
Query: 207 GLGITVAGYVCEKEELS-GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSV 265
GLG++V G ++ GIFVKSII G +A + G++++ND++I V+G SL K+N ++
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 266 EILRNT 271
E LR +
Sbjct: 660 ETLRRS 665
Score = 52.4 bits (120), Expect = 5e-06
Identities = 37/114 (32%), Positives = 60/114 (52%), Gaps = 10/114 (8%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 462 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPADP--ATALRAPQPGTALVPTKILADPE 117
+ E+V ++LR + V LLV R D L A +P +P + A+ E
Sbjct: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNA-EPSQMQIPKETKAEDE 574
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 462 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 521 GKSQEEVVSLLRSTKMEGTVSLLVFR 546
Score = 48.8 bits (111), Expect = 6e-05
Identities = 45/158 (28%), Positives = 75/158 (47%), Gaps = 17/158 (10%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 591 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 650
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 651 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 710
Query: 117 ELLDRHLIETGY-GAVYDLSQCYSDYNINGQNGETETS 153
E H + +G G S+ + I G++G+ + S
Sbjct: 711 ERRISHSLYSGIEGLDESPSRNAALSRIMGESGKYQLS 748
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 660 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 695
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 466 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 522
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 523 SQEEVVSLLR 532
>AL392123-2|CAI17332.1| 1353|Homo sapiens par-3 partitioning
defective 3 homolog (C. elegans) protein.
Length = 1353
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 272 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 332 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 391
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 392 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 442
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 443 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 502
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 503 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 534
Score = 58.8 bits (136), Expect = 6e-08
Identities = 28/66 (42%), Positives = 45/66 (68%), Gaps = 1/66 (1%)
Query: 207 GLGITVAGYVCEKEELS-GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSV 265
GLG++V G ++ GIFVKSII G +A + G++++ND++I V+G SL K+N ++
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 266 EILRNT 271
E LR +
Sbjct: 660 ETLRRS 665
Score = 52.4 bits (120), Expect = 5e-06
Identities = 37/114 (32%), Positives = 60/114 (52%), Gaps = 10/114 (8%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 462 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPADP--ATALRAPQPGTALVPTKILADPE 117
+ E+V ++LR + V LLV R D L A +P +P + A+ E
Sbjct: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNA-EPSQMQIPKETKAEDE 574
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 462 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 521 GKSQEEVVSLLRSTKMEGTVSLLVFR 546
Score = 48.4 bits (110), Expect = 8e-05
Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 16/131 (12%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 591 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 650
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 651 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 710
Query: 117 ELLDRHLIETG 127
E H + +G
Sbjct: 711 ERRISHSLYSG 721
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 660 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 695
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 466 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 522
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 523 SQEEVVSLLR 532
>AL392123-1|CAI17331.1| 1356|Homo sapiens par-3 partitioning
defective 3 homolog (C. elegans) protein.
Length = 1356
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 272 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 332 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 391
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 392 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 442
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 443 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 502
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 503 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 534
Score = 58.8 bits (136), Expect = 6e-08
Identities = 28/66 (42%), Positives = 45/66 (68%), Gaps = 1/66 (1%)
Query: 207 GLGITVAGYVCEKEELS-GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSV 265
GLG++V G ++ GIFVKSII G +A + G++++ND++I V+G SL K+N ++
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 266 EILRNT 271
E LR +
Sbjct: 660 ETLRRS 665
Score = 52.4 bits (120), Expect = 5e-06
Identities = 37/114 (32%), Positives = 60/114 (52%), Gaps = 10/114 (8%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 462 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPADP--ATALRAPQPGTALVPTKILADPE 117
+ E+V ++LR + V LLV R D L A +P +P + A+ E
Sbjct: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNA-EPSQMQIPKETKAEDE 574
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 462 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 521 GKSQEEVVSLLRSTKMEGTVSLLVFR 546
Score = 48.8 bits (111), Expect = 6e-05
Identities = 45/158 (28%), Positives = 75/158 (47%), Gaps = 17/158 (10%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 591 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 650
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 651 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 710
Query: 117 ELLDRHLIETGY-GAVYDLSQCYSDYNINGQNGETETS 153
E H + +G G S+ + I G++G+ + S
Sbjct: 711 ERRISHSLYSGIEGLDESPSRNAALSRIMGESGKYQLS 748
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 660 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 695
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 466 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 522
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 523 SQEEVVSLLR 532
>AL390766-8|CAI17310.1| 988|Homo sapiens par-3 partitioning
defective 3 homolog (C. elegans) protein.
Length = 988
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 272 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 332 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 391
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 392 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 442
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 443 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 502
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 503 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 534
Score = 60.1 bits (139), Expect = 2e-08
Identities = 37/102 (36%), Positives = 57/102 (55%), Gaps = 3/102 (2%)
Query: 172 HPIVCDSVSPTITITVPVELPEIEIIHVDLNKN-VYGLGITVAGYVCEKEELS-GIFVKS 229
HP + I +T P E V LN + GLG++V G ++ GIFVKS
Sbjct: 552 HPRELKAEDEDIVLT-PDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKS 610
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
II G +A + G++++ND++I V+G SL K+N ++E LR +
Sbjct: 611 IINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRS 652
Score = 51.6 bits (118), Expect = 9e-06
Identities = 31/88 (35%), Positives = 50/88 (56%), Gaps = 7/88 (7%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 462 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPAD 93
+ E+V ++LR + V LLV R D
Sbjct: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQED 549
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 462 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 521 GKSQEEVVSLLRSTKMEGTVSLLVFR 546
Score = 48.4 bits (110), Expect = 8e-05
Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 16/131 (12%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 578 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 637
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 638 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 697
Query: 117 ELLDRHLIETG 127
E H + +G
Sbjct: 698 ERRISHSLYSG 708
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 587 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 646
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 647 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 682
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 466 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 522
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 523 SQEEVVSLLR 532
>AL390766-7|CAI17311.1| 1001|Homo sapiens par-3 partitioning
defective 3 homolog (C. elegans) protein.
Length = 1001
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 272 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 332 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 391
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 392 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 442
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 443 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 502
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 503 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 534
Score = 58.8 bits (136), Expect = 6e-08
Identities = 28/66 (42%), Positives = 45/66 (68%), Gaps = 1/66 (1%)
Query: 207 GLGITVAGYVCEKEELS-GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSV 265
GLG++V G ++ GIFVKSII G +A + G++++ND++I V+G SL K+N ++
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 266 EILRNT 271
E LR +
Sbjct: 660 ETLRRS 665
Score = 52.4 bits (120), Expect = 5e-06
Identities = 37/114 (32%), Positives = 60/114 (52%), Gaps = 10/114 (8%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 462 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPADP--ATALRAPQPGTALVPTKILADPE 117
+ E+V ++LR + V LLV R D L A +P +P + A+ E
Sbjct: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNA-EPSQMQIPKETKAEDE 574
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 462 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 521 GKSQEEVVSLLRSTKMEGTVSLLVFR 546
Score = 48.4 bits (110), Expect = 8e-05
Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 16/131 (12%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 591 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 650
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 651 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 710
Query: 117 ELLDRHLIETG 127
E H + +G
Sbjct: 711 ERRISHSLYSG 721
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 660 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 695
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 466 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 522
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 523 SQEEVVSLLR 532
>AL390766-6|CAI17307.1| 1296|Homo sapiens par-3 partitioning
defective 3 homolog (C. elegans) protein.
Length = 1296
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 228 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 287
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 288 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 347
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 348 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 398
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 399 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 458
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 459 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 490
Score = 60.1 bits (139), Expect = 2e-08
Identities = 37/102 (36%), Positives = 57/102 (55%), Gaps = 3/102 (2%)
Query: 172 HPIVCDSVSPTITITVPVELPEIEIIHVDLNKN-VYGLGITVAGYVCEKEELS-GIFVKS 229
HP + I +T P E V LN + GLG++V G ++ GIFVKS
Sbjct: 508 HPRELKAEDEDIVLT-PDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKS 566
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
II G +A + G++++ND++I V+G SL K+N ++E LR +
Sbjct: 567 IINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRS 608
Score = 51.6 bits (118), Expect = 9e-06
Identities = 31/88 (35%), Positives = 50/88 (56%), Gaps = 7/88 (7%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 418 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 477
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPAD 93
+ E+V ++LR + V LLV R D
Sbjct: 478 KSQEEVVSLLRSTKMEGTVSLLVFRQED 505
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 418 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 476
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 477 GKSQEEVVSLLRSTKMEGTVSLLVFR 502
Score = 48.4 bits (110), Expect = 8e-05
Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 16/131 (12%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 534 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 593
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 594 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 653
Query: 117 ELLDRHLIETG 127
E H + +G
Sbjct: 654 ERRISHSLYSG 664
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 543 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 602
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 603 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 638
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 422 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 478
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 479 SQEEVVSLLR 488
>AL390766-5|CAI17306.1| 1310|Homo sapiens par-3 partitioning
defective 3 homolog (C. elegans) protein.
Length = 1310
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 272 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 332 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 391
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 392 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 442
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 443 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 502
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 503 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 534
Score = 60.1 bits (139), Expect = 2e-08
Identities = 37/102 (36%), Positives = 57/102 (55%), Gaps = 3/102 (2%)
Query: 172 HPIVCDSVSPTITITVPVELPEIEIIHVDLNKN-VYGLGITVAGYVCEKEELS-GIFVKS 229
HP + I +T P E V LN + GLG++V G ++ GIFVKS
Sbjct: 552 HPRELKAEDEDIVLT-PDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKS 610
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
II G +A + G++++ND++I V+G SL K+N ++E LR +
Sbjct: 611 IINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRS 652
Score = 51.6 bits (118), Expect = 9e-06
Identities = 31/88 (35%), Positives = 50/88 (56%), Gaps = 7/88 (7%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 462 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPAD 93
+ E+V ++LR + V LLV R D
Sbjct: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQED 549
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 462 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 521 GKSQEEVVSLLRSTKMEGTVSLLVFR 546
Score = 48.4 bits (110), Expect = 8e-05
Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 16/131 (12%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 578 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 637
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 638 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 697
Query: 117 ELLDRHLIETG 127
E H + +G
Sbjct: 698 ERRISHSLYSG 708
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 587 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 646
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 647 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 682
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 466 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 522
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 523 SQEEVVSLLR 532
>AL390766-4|CAI17305.1| 1244|Homo sapiens par-3 partitioning
defective 3 homolog (C. elegans) protein.
Length = 1244
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 228 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 287
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 288 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 347
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 348 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 398
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 399 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 458
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 459 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 490
Score = 60.1 bits (139), Expect = 2e-08
Identities = 37/102 (36%), Positives = 57/102 (55%), Gaps = 3/102 (2%)
Query: 172 HPIVCDSVSPTITITVPVELPEIEIIHVDLNKN-VYGLGITVAGYVCEKEELS-GIFVKS 229
HP + I +T P E V LN + GLG++V G ++ GIFVKS
Sbjct: 508 HPRELKAEDEDIVLT-PDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKS 566
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
II G +A + G++++ND++I V+G SL K+N ++E LR +
Sbjct: 567 IINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRS 608
Score = 51.6 bits (118), Expect = 9e-06
Identities = 31/88 (35%), Positives = 50/88 (56%), Gaps = 7/88 (7%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 418 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 477
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPAD 93
+ E+V ++LR + V LLV R D
Sbjct: 478 KSQEEVVSLLRSTKMEGTVSLLVFRQED 505
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 418 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 476
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 477 GKSQEEVVSLLRSTKMEGTVSLLVFR 502
Score = 48.4 bits (110), Expect = 8e-05
Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 16/131 (12%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 534 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 593
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 594 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 653
Query: 117 ELLDRHLIETG 127
E H + +G
Sbjct: 654 ERRISHSLYSG 664
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 543 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 602
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 603 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 638
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 422 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 478
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 479 SQEEVVSLLR 488
>AL390766-3|CAI17304.1| 1319|Homo sapiens par-3 partitioning
defective 3 homolog (C. elegans) protein.
Length = 1319
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 272 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 332 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 391
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 392 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 442
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 443 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 502
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 503 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 534
Score = 58.8 bits (136), Expect = 6e-08
Identities = 28/66 (42%), Positives = 45/66 (68%), Gaps = 1/66 (1%)
Query: 207 GLGITVAGYVCEKEELS-GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSV 265
GLG++V G ++ GIFVKSII G +A + G++++ND++I V+G SL K+N ++
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 266 EILRNT 271
E LR +
Sbjct: 660 ETLRRS 665
Score = 52.4 bits (120), Expect = 5e-06
Identities = 37/114 (32%), Positives = 60/114 (52%), Gaps = 10/114 (8%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 462 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPADP--ATALRAPQPGTALVPTKILADPE 117
+ E+V ++LR + V LLV R D L A +P +P + A+ E
Sbjct: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNA-EPSQMQIPKETKAEDE 574
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 462 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 521 GKSQEEVVSLLRSTKMEGTVSLLVFR 546
Score = 48.8 bits (111), Expect = 6e-05
Identities = 45/158 (28%), Positives = 75/158 (47%), Gaps = 17/158 (10%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 591 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 650
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 651 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 710
Query: 117 ELLDRHLIETGY-GAVYDLSQCYSDYNINGQNGETETS 153
E H + +G G S+ + I G++G+ + S
Sbjct: 711 ERRISHSLYSGIEGLDESPSRNAALSRIMGESGKYQLS 748
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 660 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 695
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 466 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 522
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 523 SQEEVVSLLR 532
>AL390766-2|CAI17309.1| 1353|Homo sapiens par-3 partitioning
defective 3 homolog (C. elegans) protein.
Length = 1353
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 272 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 332 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 391
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 392 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 442
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 443 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 502
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 503 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 534
Score = 58.8 bits (136), Expect = 6e-08
Identities = 28/66 (42%), Positives = 45/66 (68%), Gaps = 1/66 (1%)
Query: 207 GLGITVAGYVCEKEELS-GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSV 265
GLG++V G ++ GIFVKSII G +A + G++++ND++I V+G SL K+N ++
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 266 EILRNT 271
E LR +
Sbjct: 660 ETLRRS 665
Score = 52.4 bits (120), Expect = 5e-06
Identities = 37/114 (32%), Positives = 60/114 (52%), Gaps = 10/114 (8%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 462 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPADP--ATALRAPQPGTALVPTKILADPE 117
+ E+V ++LR + V LLV R D L A +P +P + A+ E
Sbjct: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNA-EPSQMQIPKETKAEDE 574
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 462 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 521 GKSQEEVVSLLRSTKMEGTVSLLVFR 546
Score = 48.4 bits (110), Expect = 8e-05
Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 16/131 (12%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 591 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 650
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 651 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 710
Query: 117 ELLDRHLIETG 127
E H + +G
Sbjct: 711 ERRISHSLYSG 721
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 660 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 695
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 466 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 522
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 523 SQEEVVSLLR 532
>AL390766-1|CAI17308.1| 1356|Homo sapiens par-3 partitioning
defective 3 homolog (C. elegans) protein.
Length = 1356
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 272 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 332 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 391
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 392 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 442
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 443 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 502
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 503 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 534
Score = 58.8 bits (136), Expect = 6e-08
Identities = 28/66 (42%), Positives = 45/66 (68%), Gaps = 1/66 (1%)
Query: 207 GLGITVAGYVCEKEELS-GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSV 265
GLG++V G ++ GIFVKSII G +A + G++++ND++I V+G SL K+N ++
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 266 EILRNT 271
E LR +
Sbjct: 660 ETLRRS 665
Score = 52.4 bits (120), Expect = 5e-06
Identities = 37/114 (32%), Positives = 60/114 (52%), Gaps = 10/114 (8%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 462 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPADP--ATALRAPQPGTALVPTKILADPE 117
+ E+V ++LR + V LLV R D L A +P +P + A+ E
Sbjct: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNA-EPSQMQIPKETKAEDE 574
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 462 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 521 GKSQEEVVSLLRSTKMEGTVSLLVFR 546
Score = 48.8 bits (111), Expect = 6e-05
Identities = 45/158 (28%), Positives = 75/158 (47%), Gaps = 17/158 (10%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 591 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 650
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 651 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 710
Query: 117 ELLDRHLIETGY-GAVYDLSQCYSDYNINGQNGETETS 153
E H + +G G S+ + I G++G+ + S
Sbjct: 711 ERRISHSLYSGIEGLDESPSRNAALSRIMGESGKYQLS 748
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 660 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 695
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 466 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 522
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 523 SQEEVVSLLR 532
>AL360233-8|CAH71168.1| 1001|Homo sapiens par-3 partitioning
defective 3 homolog (C. elegans) protein.
Length = 1001
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 272 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 332 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 391
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 392 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 442
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 443 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 502
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 503 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 534
Score = 58.8 bits (136), Expect = 6e-08
Identities = 28/66 (42%), Positives = 45/66 (68%), Gaps = 1/66 (1%)
Query: 207 GLGITVAGYVCEKEELS-GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSV 265
GLG++V G ++ GIFVKSII G +A + G++++ND++I V+G SL K+N ++
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 266 EILRNT 271
E LR +
Sbjct: 660 ETLRRS 665
Score = 52.4 bits (120), Expect = 5e-06
Identities = 37/114 (32%), Positives = 60/114 (52%), Gaps = 10/114 (8%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 462 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPADP--ATALRAPQPGTALVPTKILADPE 117
+ E+V ++LR + V LLV R D L A +P +P + A+ E
Sbjct: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNA-EPSQMQIPKETKAEDE 574
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 462 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 521 GKSQEEVVSLLRSTKMEGTVSLLVFR 546
Score = 48.4 bits (110), Expect = 8e-05
Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 16/131 (12%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 591 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 650
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 651 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 710
Query: 117 ELLDRHLIETG 127
E H + +G
Sbjct: 711 ERRISHSLYSG 721
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 660 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 695
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 466 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 522
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 523 SQEEVVSLLR 532
>AL360233-7|CAH71167.1| 988|Homo sapiens par-3 partitioning
defective 3 homolog (C. elegans) protein.
Length = 988
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 272 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 332 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 391
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 392 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 442
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 443 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 502
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 503 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 534
Score = 60.1 bits (139), Expect = 2e-08
Identities = 37/102 (36%), Positives = 57/102 (55%), Gaps = 3/102 (2%)
Query: 172 HPIVCDSVSPTITITVPVELPEIEIIHVDLNKN-VYGLGITVAGYVCEKEELS-GIFVKS 229
HP + I +T P E V LN + GLG++V G ++ GIFVKS
Sbjct: 552 HPRELKAEDEDIVLT-PDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKS 610
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
II G +A + G++++ND++I V+G SL K+N ++E LR +
Sbjct: 611 IINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRS 652
Score = 51.6 bits (118), Expect = 9e-06
Identities = 31/88 (35%), Positives = 50/88 (56%), Gaps = 7/88 (7%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 462 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPAD 93
+ E+V ++LR + V LLV R D
Sbjct: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQED 549
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 462 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 521 GKSQEEVVSLLRSTKMEGTVSLLVFR 546
Score = 48.4 bits (110), Expect = 8e-05
Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 16/131 (12%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 578 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 637
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 638 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 697
Query: 117 ELLDRHLIETG 127
E H + +G
Sbjct: 698 ERRISHSLYSG 708
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 587 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 646
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 647 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 682
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 466 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 522
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 523 SQEEVVSLLR 532
>AL360233-6|CAH71161.1| 1310|Homo sapiens par-3 partitioning
defective 3 homolog (C. elegans) protein.
Length = 1310
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 272 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 332 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 391
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 392 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 442
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 443 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 502
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 503 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 534
Score = 60.1 bits (139), Expect = 2e-08
Identities = 37/102 (36%), Positives = 57/102 (55%), Gaps = 3/102 (2%)
Query: 172 HPIVCDSVSPTITITVPVELPEIEIIHVDLNKN-VYGLGITVAGYVCEKEELS-GIFVKS 229
HP + I +T P E V LN + GLG++V G ++ GIFVKS
Sbjct: 552 HPRELKAEDEDIVLT-PDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKS 610
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
II G +A + G++++ND++I V+G SL K+N ++E LR +
Sbjct: 611 IINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRS 652
Score = 51.6 bits (118), Expect = 9e-06
Identities = 31/88 (35%), Positives = 50/88 (56%), Gaps = 7/88 (7%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 462 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPAD 93
+ E+V ++LR + V LLV R D
Sbjct: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQED 549
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 462 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 521 GKSQEEVVSLLRSTKMEGTVSLLVFR 546
Score = 48.4 bits (110), Expect = 8e-05
Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 16/131 (12%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 578 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 637
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 638 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 697
Query: 117 ELLDRHLIETG 127
E H + +G
Sbjct: 698 ERRISHSLYSG 708
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 587 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 646
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 647 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 682
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 466 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 522
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 523 SQEEVVSLLR 532
>AL360233-5|CAH71163.1| 1244|Homo sapiens par-3 partitioning
defective 3 homolog (C. elegans) protein.
Length = 1244
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 228 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 287
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 288 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 347
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 348 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 398
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 399 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 458
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 459 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 490
Score = 60.1 bits (139), Expect = 2e-08
Identities = 37/102 (36%), Positives = 57/102 (55%), Gaps = 3/102 (2%)
Query: 172 HPIVCDSVSPTITITVPVELPEIEIIHVDLNKN-VYGLGITVAGYVCEKEELS-GIFVKS 229
HP + I +T P E V LN + GLG++V G ++ GIFVKS
Sbjct: 508 HPRELKAEDEDIVLT-PDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKS 566
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
II G +A + G++++ND++I V+G SL K+N ++E LR +
Sbjct: 567 IINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRS 608
Score = 51.6 bits (118), Expect = 9e-06
Identities = 31/88 (35%), Positives = 50/88 (56%), Gaps = 7/88 (7%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 418 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 477
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPAD 93
+ E+V ++LR + V LLV R D
Sbjct: 478 KSQEEVVSLLRSTKMEGTVSLLVFRQED 505
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 418 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 476
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 477 GKSQEEVVSLLRSTKMEGTVSLLVFR 502
Score = 48.4 bits (110), Expect = 8e-05
Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 16/131 (12%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 534 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 593
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 594 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 653
Query: 117 ELLDRHLIETG 127
E H + +G
Sbjct: 654 ERRISHSLYSG 664
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 543 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 602
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 603 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 638
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 422 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 478
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 479 SQEEVVSLLR 488
>AL360233-4|CAH71162.1| 1319|Homo sapiens par-3 partitioning
defective 3 homolog (C. elegans) protein.
Length = 1319
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 272 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 332 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 391
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 392 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 442
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 443 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 502
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 503 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 534
Score = 58.8 bits (136), Expect = 6e-08
Identities = 28/66 (42%), Positives = 45/66 (68%), Gaps = 1/66 (1%)
Query: 207 GLGITVAGYVCEKEELS-GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSV 265
GLG++V G ++ GIFVKSII G +A + G++++ND++I V+G SL K+N ++
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 266 EILRNT 271
E LR +
Sbjct: 660 ETLRRS 665
Score = 52.4 bits (120), Expect = 5e-06
Identities = 37/114 (32%), Positives = 60/114 (52%), Gaps = 10/114 (8%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 462 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPADP--ATALRAPQPGTALVPTKILADPE 117
+ E+V ++LR + V LLV R D L A +P +P + A+ E
Sbjct: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNA-EPSQMQIPKETKAEDE 574
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 462 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 521 GKSQEEVVSLLRSTKMEGTVSLLVFR 546
Score = 48.8 bits (111), Expect = 6e-05
Identities = 45/158 (28%), Positives = 75/158 (47%), Gaps = 17/158 (10%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 591 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 650
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 651 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 710
Query: 117 ELLDRHLIETGY-GAVYDLSQCYSDYNINGQNGETETS 153
E H + +G G S+ + I G++G+ + S
Sbjct: 711 ERRISHSLYSGIEGLDESPSRNAALSRIMGESGKYQLS 748
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 660 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 695
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 466 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 522
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 523 SQEEVVSLLR 532
>AL360233-3|CAH71166.1| 1353|Homo sapiens par-3 partitioning
defective 3 homolog (C. elegans) protein.
Length = 1353
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 272 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 332 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 391
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 392 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 442
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 443 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 502
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 503 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 534
Score = 58.8 bits (136), Expect = 6e-08
Identities = 28/66 (42%), Positives = 45/66 (68%), Gaps = 1/66 (1%)
Query: 207 GLGITVAGYVCEKEELS-GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSV 265
GLG++V G ++ GIFVKSII G +A + G++++ND++I V+G SL K+N ++
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 266 EILRNT 271
E LR +
Sbjct: 660 ETLRRS 665
Score = 52.4 bits (120), Expect = 5e-06
Identities = 37/114 (32%), Positives = 60/114 (52%), Gaps = 10/114 (8%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 462 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPADP--ATALRAPQPGTALVPTKILADPE 117
+ E+V ++LR + V LLV R D L A +P +P + A+ E
Sbjct: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNA-EPSQMQIPKETKAEDE 574
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 462 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 521 GKSQEEVVSLLRSTKMEGTVSLLVFR 546
Score = 48.4 bits (110), Expect = 8e-05
Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 16/131 (12%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 591 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 650
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 651 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 710
Query: 117 ELLDRHLIETG 127
E H + +G
Sbjct: 711 ERRISHSLYSG 721
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 660 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 695
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 466 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 522
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 523 SQEEVVSLLR 532
>AL360233-2|CAH71165.1| 1356|Homo sapiens par-3 partitioning
defective 3 homolog (C. elegans) protein.
Length = 1356
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 272 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 332 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 391
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 392 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 442
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 443 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 502
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 503 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 534
Score = 58.8 bits (136), Expect = 6e-08
Identities = 28/66 (42%), Positives = 45/66 (68%), Gaps = 1/66 (1%)
Query: 207 GLGITVAGYVCEKEELS-GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSV 265
GLG++V G ++ GIFVKSII G +A + G++++ND++I V+G SL K+N ++
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 266 EILRNT 271
E LR +
Sbjct: 660 ETLRRS 665
Score = 52.4 bits (120), Expect = 5e-06
Identities = 37/114 (32%), Positives = 60/114 (52%), Gaps = 10/114 (8%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 462 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPADP--ATALRAPQPGTALVPTKILADPE 117
+ E+V ++LR + V LLV R D L A +P +P + A+ E
Sbjct: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNA-EPSQMQIPKETKAEDE 574
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 462 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 521 GKSQEEVVSLLRSTKMEGTVSLLVFR 546
Score = 48.8 bits (111), Expect = 6e-05
Identities = 45/158 (28%), Positives = 75/158 (47%), Gaps = 17/158 (10%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 591 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 650
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 651 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 710
Query: 117 ELLDRHLIETGY-GAVYDLSQCYSDYNINGQNGETETS 153
E H + +G G S+ + I G++G+ + S
Sbjct: 711 ERRISHSLYSGIEGLDESPSRNAALSRIMGESGKYQLS 748
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 660 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 695
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 466 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 522
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 523 SQEEVVSLLR 532
>AL360233-1|CAH71164.1| 1296|Homo sapiens par-3 partitioning
defective 3 homolog (C. elegans) protein.
Length = 1296
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 228 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 287
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 288 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 347
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 348 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 398
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 399 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 458
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 459 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 490
Score = 60.1 bits (139), Expect = 2e-08
Identities = 37/102 (36%), Positives = 57/102 (55%), Gaps = 3/102 (2%)
Query: 172 HPIVCDSVSPTITITVPVELPEIEIIHVDLNKN-VYGLGITVAGYVCEKEELS-GIFVKS 229
HP + I +T P E V LN + GLG++V G ++ GIFVKS
Sbjct: 508 HPRELKAEDEDIVLT-PDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKS 566
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
II G +A + G++++ND++I V+G SL K+N ++E LR +
Sbjct: 567 IINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRS 608
Score = 51.6 bits (118), Expect = 9e-06
Identities = 31/88 (35%), Positives = 50/88 (56%), Gaps = 7/88 (7%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 418 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 477
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPAD 93
+ E+V ++LR + V LLV R D
Sbjct: 478 KSQEEVVSLLRSTKMEGTVSLLVFRQED 505
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 418 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 476
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 477 GKSQEEVVSLLRSTKMEGTVSLLVFR 502
Score = 48.4 bits (110), Expect = 8e-05
Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 16/131 (12%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 534 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 593
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 594 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 653
Query: 117 ELLDRHLIETG 127
E H + +G
Sbjct: 654 ERRISHSLYSG 664
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 543 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 602
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 603 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 638
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 422 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 478
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 479 SQEEVVSLLR 488
>AL160409-6|CAH73527.1| 1296|Homo sapiens par-3 partitioning
defective 3 homolog (C. elegans) protein.
Length = 1296
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 228 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 287
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 288 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 347
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 348 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 398
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 399 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 458
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 459 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 490
Score = 60.1 bits (139), Expect = 2e-08
Identities = 37/102 (36%), Positives = 57/102 (55%), Gaps = 3/102 (2%)
Query: 172 HPIVCDSVSPTITITVPVELPEIEIIHVDLNKN-VYGLGITVAGYVCEKEELS-GIFVKS 229
HP + I +T P E V LN + GLG++V G ++ GIFVKS
Sbjct: 508 HPRELKAEDEDIVLT-PDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKS 566
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
II G +A + G++++ND++I V+G SL K+N ++E LR +
Sbjct: 567 IINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRS 608
Score = 51.6 bits (118), Expect = 9e-06
Identities = 31/88 (35%), Positives = 50/88 (56%), Gaps = 7/88 (7%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 418 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 477
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPAD 93
+ E+V ++LR + V LLV R D
Sbjct: 478 KSQEEVVSLLRSTKMEGTVSLLVFRQED 505
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 418 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 476
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 477 GKSQEEVVSLLRSTKMEGTVSLLVFR 502
Score = 48.4 bits (110), Expect = 8e-05
Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 16/131 (12%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 534 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 593
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 594 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 653
Query: 117 ELLDRHLIETG 127
E H + +G
Sbjct: 654 ERRISHSLYSG 664
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 543 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 602
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 603 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 638
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 422 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 478
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 479 SQEEVVSLLR 488
>AL160409-5|CAH73526.1| 1310|Homo sapiens par-3 partitioning
defective 3 homolog (C. elegans) protein.
Length = 1310
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 272 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 332 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 391
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 392 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 442
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 443 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 502
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 503 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 534
Score = 60.1 bits (139), Expect = 2e-08
Identities = 37/102 (36%), Positives = 57/102 (55%), Gaps = 3/102 (2%)
Query: 172 HPIVCDSVSPTITITVPVELPEIEIIHVDLNKN-VYGLGITVAGYVCEKEELS-GIFVKS 229
HP + I +T P E V LN + GLG++V G ++ GIFVKS
Sbjct: 552 HPRELKAEDEDIVLT-PDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKS 610
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
II G +A + G++++ND++I V+G SL K+N ++E LR +
Sbjct: 611 IINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRS 652
Score = 51.6 bits (118), Expect = 9e-06
Identities = 31/88 (35%), Positives = 50/88 (56%), Gaps = 7/88 (7%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 462 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPAD 93
+ E+V ++LR + V LLV R D
Sbjct: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQED 549
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 462 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 521 GKSQEEVVSLLRSTKMEGTVSLLVFR 546
Score = 48.4 bits (110), Expect = 8e-05
Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 16/131 (12%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 578 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 637
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 638 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 697
Query: 117 ELLDRHLIETG 127
E H + +G
Sbjct: 698 ERRISHSLYSG 708
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 587 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 646
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 647 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 682
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 466 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 522
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 523 SQEEVVSLLR 532
>AL160409-4|CAH73525.1| 1244|Homo sapiens par-3 partitioning
defective 3 homolog (C. elegans) protein.
Length = 1244
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 228 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 287
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 288 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 347
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 348 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 398
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 399 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 458
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 459 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 490
Score = 60.1 bits (139), Expect = 2e-08
Identities = 37/102 (36%), Positives = 57/102 (55%), Gaps = 3/102 (2%)
Query: 172 HPIVCDSVSPTITITVPVELPEIEIIHVDLNKN-VYGLGITVAGYVCEKEELS-GIFVKS 229
HP + I +T P E V LN + GLG++V G ++ GIFVKS
Sbjct: 508 HPRELKAEDEDIVLT-PDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKS 566
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
II G +A + G++++ND++I V+G SL K+N ++E LR +
Sbjct: 567 IINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRS 608
Score = 51.6 bits (118), Expect = 9e-06
Identities = 31/88 (35%), Positives = 50/88 (56%), Gaps = 7/88 (7%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 418 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 477
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPAD 93
+ E+V ++LR + V LLV R D
Sbjct: 478 KSQEEVVSLLRSTKMEGTVSLLVFRQED 505
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 418 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 476
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 477 GKSQEEVVSLLRSTKMEGTVSLLVFR 502
Score = 48.4 bits (110), Expect = 8e-05
Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 16/131 (12%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 534 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 593
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 594 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 653
Query: 117 ELLDRHLIETG 127
E H + +G
Sbjct: 654 ERRISHSLYSG 664
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 543 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 602
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 603 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 638
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 422 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 478
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 479 SQEEVVSLLR 488
>AL160409-3|CAH73524.1| 1319|Homo sapiens par-3 partitioning
defective 3 homolog (C. elegans) protein.
Length = 1319
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 272 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 332 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 391
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 392 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 442
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 443 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 502
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 503 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 534
Score = 58.8 bits (136), Expect = 6e-08
Identities = 28/66 (42%), Positives = 45/66 (68%), Gaps = 1/66 (1%)
Query: 207 GLGITVAGYVCEKEELS-GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSV 265
GLG++V G ++ GIFVKSII G +A + G++++ND++I V+G SL K+N ++
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 266 EILRNT 271
E LR +
Sbjct: 660 ETLRRS 665
Score = 52.4 bits (120), Expect = 5e-06
Identities = 37/114 (32%), Positives = 60/114 (52%), Gaps = 10/114 (8%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 462 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPADP--ATALRAPQPGTALVPTKILADPE 117
+ E+V ++LR + V LLV R D L A +P +P + A+ E
Sbjct: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNA-EPSQMQIPKETKAEDE 574
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 462 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 521 GKSQEEVVSLLRSTKMEGTVSLLVFR 546
Score = 48.8 bits (111), Expect = 6e-05
Identities = 45/158 (28%), Positives = 75/158 (47%), Gaps = 17/158 (10%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 591 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 650
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 651 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 710
Query: 117 ELLDRHLIETGY-GAVYDLSQCYSDYNINGQNGETETS 153
E H + +G G S+ + I G++G+ + S
Sbjct: 711 ERRISHSLYSGIEGLDESPSRNAALSRIMGESGKYQLS 748
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 660 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 695
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 466 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 522
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 523 SQEEVVSLLR 532
>AL160409-2|CAH73529.1| 1353|Homo sapiens par-3 partitioning
defective 3 homolog (C. elegans) protein.
Length = 1353
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 272 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 332 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 391
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 392 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 442
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 443 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 502
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 503 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 534
Score = 58.8 bits (136), Expect = 6e-08
Identities = 28/66 (42%), Positives = 45/66 (68%), Gaps = 1/66 (1%)
Query: 207 GLGITVAGYVCEKEELS-GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSV 265
GLG++V G ++ GIFVKSII G +A + G++++ND++I V+G SL K+N ++
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 266 EILRNT 271
E LR +
Sbjct: 660 ETLRRS 665
Score = 52.4 bits (120), Expect = 5e-06
Identities = 37/114 (32%), Positives = 60/114 (52%), Gaps = 10/114 (8%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 462 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPADP--ATALRAPQPGTALVPTKILADPE 117
+ E+V ++LR + V LLV R D L A +P +P + A+ E
Sbjct: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNA-EPSQMQIPKETKAEDE 574
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 462 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 521 GKSQEEVVSLLRSTKMEGTVSLLVFR 546
Score = 48.4 bits (110), Expect = 8e-05
Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 16/131 (12%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 591 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 650
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 651 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 710
Query: 117 ELLDRHLIETG 127
E H + +G
Sbjct: 711 ERRISHSLYSG 721
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 660 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 695
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 466 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 522
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 523 SQEEVVSLLR 532
>AL160409-1|CAH73528.1| 1356|Homo sapiens par-3 partitioning
defective 3 homolog (C. elegans) protein.
Length = 1356
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 272 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 332 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 391
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 392 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 442
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 443 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 502
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 503 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 534
Score = 58.8 bits (136), Expect = 6e-08
Identities = 28/66 (42%), Positives = 45/66 (68%), Gaps = 1/66 (1%)
Query: 207 GLGITVAGYVCEKEELS-GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSV 265
GLG++V G ++ GIFVKSII G +A + G++++ND++I V+G SL K+N ++
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 266 EILRNT 271
E LR +
Sbjct: 660 ETLRRS 665
Score = 52.4 bits (120), Expect = 5e-06
Identities = 37/114 (32%), Positives = 60/114 (52%), Gaps = 10/114 (8%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 462 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPADP--ATALRAPQPGTALVPTKILADPE 117
+ E+V ++LR + V LLV R D L A +P +P + A+ E
Sbjct: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNA-EPSQMQIPKETKAEDE 574
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 462 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 521 GKSQEEVVSLLRSTKMEGTVSLLVFR 546
Score = 48.8 bits (111), Expect = 6e-05
Identities = 45/158 (28%), Positives = 75/158 (47%), Gaps = 17/158 (10%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 591 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 650
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 651 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 710
Query: 117 ELLDRHLIETGY-GAVYDLSQCYSDYNINGQNGETETS 153
E H + +G G S+ + I G++G+ + S
Sbjct: 711 ERRISHSLYSGIEGLDESPSRNAALSRIMGESGKYQLS 748
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 660 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 695
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 466 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 522
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 523 SQEEVVSLLR 532
>AL138768-8|CAI16991.1| 988|Homo sapiens par-3 partitioning
defective 3 homolog (C. elegans) protein.
Length = 988
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 272 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 332 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 391
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 392 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 442
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 443 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 502
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 503 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 534
Score = 60.1 bits (139), Expect = 2e-08
Identities = 37/102 (36%), Positives = 57/102 (55%), Gaps = 3/102 (2%)
Query: 172 HPIVCDSVSPTITITVPVELPEIEIIHVDLNKN-VYGLGITVAGYVCEKEELS-GIFVKS 229
HP + I +T P E V LN + GLG++V G ++ GIFVKS
Sbjct: 552 HPRELKAEDEDIVLT-PDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKS 610
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
II G +A + G++++ND++I V+G SL K+N ++E LR +
Sbjct: 611 IINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRS 652
Score = 51.6 bits (118), Expect = 9e-06
Identities = 31/88 (35%), Positives = 50/88 (56%), Gaps = 7/88 (7%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 462 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPAD 93
+ E+V ++LR + V LLV R D
Sbjct: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQED 549
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 462 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 521 GKSQEEVVSLLRSTKMEGTVSLLVFR 546
Score = 48.4 bits (110), Expect = 8e-05
Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 16/131 (12%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 578 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 637
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 638 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 697
Query: 117 ELLDRHLIETG 127
E H + +G
Sbjct: 698 ERRISHSLYSG 708
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 587 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 646
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 647 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 682
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 466 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 522
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 523 SQEEVVSLLR 532
>AL138768-7|CAI16992.1| 1001|Homo sapiens par-3 partitioning
defective 3 homolog (C. elegans) protein.
Length = 1001
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 272 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 332 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 391
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 392 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 442
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 443 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 502
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 503 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 534
Score = 58.8 bits (136), Expect = 6e-08
Identities = 28/66 (42%), Positives = 45/66 (68%), Gaps = 1/66 (1%)
Query: 207 GLGITVAGYVCEKEELS-GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSV 265
GLG++V G ++ GIFVKSII G +A + G++++ND++I V+G SL K+N ++
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 266 EILRNT 271
E LR +
Sbjct: 660 ETLRRS 665
Score = 52.4 bits (120), Expect = 5e-06
Identities = 37/114 (32%), Positives = 60/114 (52%), Gaps = 10/114 (8%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 462 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPADP--ATALRAPQPGTALVPTKILADPE 117
+ E+V ++LR + V LLV R D L A +P +P + A+ E
Sbjct: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNA-EPSQMQIPKETKAEDE 574
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 462 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 521 GKSQEEVVSLLRSTKMEGTVSLLVFR 546
Score = 48.4 bits (110), Expect = 8e-05
Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 16/131 (12%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 591 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 650
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 651 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 710
Query: 117 ELLDRHLIETG 127
E H + +G
Sbjct: 711 ERRISHSLYSG 721
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 660 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 695
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 466 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 522
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 523 SQEEVVSLLR 532
>AL138768-6|CAI16985.1| 1310|Homo sapiens par-3 partitioning
defective 3 homolog (C. elegans) protein.
Length = 1310
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 272 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 332 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 391
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 392 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 442
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 443 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 502
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 503 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 534
Score = 60.1 bits (139), Expect = 2e-08
Identities = 37/102 (36%), Positives = 57/102 (55%), Gaps = 3/102 (2%)
Query: 172 HPIVCDSVSPTITITVPVELPEIEIIHVDLNKN-VYGLGITVAGYVCEKEELS-GIFVKS 229
HP + I +T P E V LN + GLG++V G ++ GIFVKS
Sbjct: 552 HPRELKAEDEDIVLT-PDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKS 610
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
II G +A + G++++ND++I V+G SL K+N ++E LR +
Sbjct: 611 IINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRS 652
Score = 51.6 bits (118), Expect = 9e-06
Identities = 31/88 (35%), Positives = 50/88 (56%), Gaps = 7/88 (7%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 462 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPAD 93
+ E+V ++LR + V LLV R D
Sbjct: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQED 549
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 462 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 521 GKSQEEVVSLLRSTKMEGTVSLLVFR 546
Score = 48.4 bits (110), Expect = 8e-05
Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 16/131 (12%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 578 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 637
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 638 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 697
Query: 117 ELLDRHLIETG 127
E H + +G
Sbjct: 698 ERRISHSLYSG 708
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 587 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 646
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 647 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 682
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 466 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 522
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 523 SQEEVVSLLR 532
>AL138768-5|CAI16987.1| 1244|Homo sapiens par-3 partitioning
defective 3 homolog (C. elegans) protein.
Length = 1244
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 228 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 287
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 288 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 347
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 348 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 398
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 399 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 458
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 459 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 490
Score = 60.1 bits (139), Expect = 2e-08
Identities = 37/102 (36%), Positives = 57/102 (55%), Gaps = 3/102 (2%)
Query: 172 HPIVCDSVSPTITITVPVELPEIEIIHVDLNKN-VYGLGITVAGYVCEKEELS-GIFVKS 229
HP + I +T P E V LN + GLG++V G ++ GIFVKS
Sbjct: 508 HPRELKAEDEDIVLT-PDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKS 566
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
II G +A + G++++ND++I V+G SL K+N ++E LR +
Sbjct: 567 IINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRS 608
Score = 51.6 bits (118), Expect = 9e-06
Identities = 31/88 (35%), Positives = 50/88 (56%), Gaps = 7/88 (7%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 418 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 477
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPAD 93
+ E+V ++LR + V LLV R D
Sbjct: 478 KSQEEVVSLLRSTKMEGTVSLLVFRQED 505
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 418 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 476
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 477 GKSQEEVVSLLRSTKMEGTVSLLVFR 502
Score = 48.4 bits (110), Expect = 8e-05
Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 16/131 (12%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 534 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 593
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 594 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 653
Query: 117 ELLDRHLIETG 127
E H + +G
Sbjct: 654 ERRISHSLYSG 664
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 543 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 602
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 603 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 638
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 422 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 478
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 479 SQEEVVSLLR 488
>AL138768-4|CAI16986.1| 1319|Homo sapiens par-3 partitioning
defective 3 homolog (C. elegans) protein.
Length = 1319
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 272 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 332 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 391
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 392 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 442
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 443 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 502
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 503 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 534
Score = 58.8 bits (136), Expect = 6e-08
Identities = 28/66 (42%), Positives = 45/66 (68%), Gaps = 1/66 (1%)
Query: 207 GLGITVAGYVCEKEELS-GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSV 265
GLG++V G ++ GIFVKSII G +A + G++++ND++I V+G SL K+N ++
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 266 EILRNT 271
E LR +
Sbjct: 660 ETLRRS 665
Score = 52.4 bits (120), Expect = 5e-06
Identities = 37/114 (32%), Positives = 60/114 (52%), Gaps = 10/114 (8%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 462 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPADP--ATALRAPQPGTALVPTKILADPE 117
+ E+V ++LR + V LLV R D L A +P +P + A+ E
Sbjct: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNA-EPSQMQIPKETKAEDE 574
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 462 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 521 GKSQEEVVSLLRSTKMEGTVSLLVFR 546
Score = 48.8 bits (111), Expect = 6e-05
Identities = 45/158 (28%), Positives = 75/158 (47%), Gaps = 17/158 (10%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 591 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 650
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 651 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 710
Query: 117 ELLDRHLIETGY-GAVYDLSQCYSDYNINGQNGETETS 153
E H + +G G S+ + I G++G+ + S
Sbjct: 711 ERRISHSLYSGIEGLDESPSRNAALSRIMGESGKYQLS 748
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 660 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 695
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 466 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 522
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 523 SQEEVVSLLR 532
>AL138768-3|CAI16989.1| 1353|Homo sapiens par-3 partitioning
defective 3 homolog (C. elegans) protein.
Length = 1353
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 272 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 332 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 391
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 392 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 442
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 443 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 502
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 503 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 534
Score = 58.8 bits (136), Expect = 6e-08
Identities = 28/66 (42%), Positives = 45/66 (68%), Gaps = 1/66 (1%)
Query: 207 GLGITVAGYVCEKEELS-GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSV 265
GLG++V G ++ GIFVKSII G +A + G++++ND++I V+G SL K+N ++
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 266 EILRNT 271
E LR +
Sbjct: 660 ETLRRS 665
Score = 52.4 bits (120), Expect = 5e-06
Identities = 37/114 (32%), Positives = 60/114 (52%), Gaps = 10/114 (8%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 462 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPADP--ATALRAPQPGTALVPTKILADPE 117
+ E+V ++LR + V LLV R D L A +P +P + A+ E
Sbjct: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNA-EPSQMQIPKETKAEDE 574
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 462 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 521 GKSQEEVVSLLRSTKMEGTVSLLVFR 546
Score = 48.4 bits (110), Expect = 8e-05
Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 16/131 (12%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 591 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 650
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 651 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 710
Query: 117 ELLDRHLIETG 127
E H + +G
Sbjct: 711 ERRISHSLYSG 721
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 660 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 695
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 466 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 522
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 523 SQEEVVSLLR 532
>AL138768-2|CAI16988.1| 1356|Homo sapiens par-3 partitioning
defective 3 homolog (C. elegans) protein.
Length = 1356
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 272 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 332 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 391
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 392 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 442
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 443 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 502
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 503 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 534
Score = 58.8 bits (136), Expect = 6e-08
Identities = 28/66 (42%), Positives = 45/66 (68%), Gaps = 1/66 (1%)
Query: 207 GLGITVAGYVCEKEELS-GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSV 265
GLG++V G ++ GIFVKSII G +A + G++++ND++I V+G SL K+N ++
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 266 EILRNT 271
E LR +
Sbjct: 660 ETLRRS 665
Score = 52.4 bits (120), Expect = 5e-06
Identities = 37/114 (32%), Positives = 60/114 (52%), Gaps = 10/114 (8%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 462 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPADP--ATALRAPQPGTALVPTKILADPE 117
+ E+V ++LR + V LLV R D L A +P +P + A+ E
Sbjct: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNA-EPSQMQIPKETKAEDE 574
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 462 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 521 GKSQEEVVSLLRSTKMEGTVSLLVFR 546
Score = 48.8 bits (111), Expect = 6e-05
Identities = 45/158 (28%), Positives = 75/158 (47%), Gaps = 17/158 (10%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 591 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 650
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 651 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 710
Query: 117 ELLDRHLIETGY-GAVYDLSQCYSDYNINGQNGETETS 153
E H + +G G S+ + I G++G+ + S
Sbjct: 711 ERRISHSLYSGIEGLDESPSRNAALSRIMGESGKYQLS 748
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 660 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 695
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 466 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 522
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 523 SQEEVVSLLR 532
>AL138768-1|CAI16990.1| 1296|Homo sapiens par-3 partitioning
defective 3 homolog (C. elegans) protein.
Length = 1296
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 228 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 287
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 288 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 347
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 348 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 398
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 399 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 458
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 459 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 490
Score = 60.1 bits (139), Expect = 2e-08
Identities = 37/102 (36%), Positives = 57/102 (55%), Gaps = 3/102 (2%)
Query: 172 HPIVCDSVSPTITITVPVELPEIEIIHVDLNKN-VYGLGITVAGYVCEKEELS-GIFVKS 229
HP + I +T P E V LN + GLG++V G ++ GIFVKS
Sbjct: 508 HPRELKAEDEDIVLT-PDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKS 566
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
II G +A + G++++ND++I V+G SL K+N ++E LR +
Sbjct: 567 IINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRS 608
Score = 51.6 bits (118), Expect = 9e-06
Identities = 31/88 (35%), Positives = 50/88 (56%), Gaps = 7/88 (7%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 418 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 477
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPAD 93
+ E+V ++LR + V LLV R D
Sbjct: 478 KSQEEVVSLLRSTKMEGTVSLLVFRQED 505
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 418 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 476
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 477 GKSQEEVVSLLRSTKMEGTVSLLVFR 502
Score = 48.4 bits (110), Expect = 8e-05
Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 16/131 (12%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 534 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 593
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 594 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 653
Query: 117 ELLDRHLIETG 127
E H + +G
Sbjct: 654 ERRISHSLYSG 664
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 543 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 602
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 603 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 638
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 422 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 478
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 479 SQEEVVSLLR 488
>AK027735-1|BAB55330.1| 865|Homo sapiens protein ( Homo sapiens
cDNA FLJ14829 fis, clone OVARC1000945, moderately
similar to Rattus norvegicus mRNA for atypical PKC
specific binding protein. ).
Length = 865
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 137 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 196
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 197 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 256
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 257 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 307
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 308 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 367
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 368 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 399
Score = 58.8 bits (136), Expect = 6e-08
Identities = 28/66 (42%), Positives = 45/66 (68%), Gaps = 1/66 (1%)
Query: 207 GLGITVAGYVCEKEELS-GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSV 265
GLG++V G ++ GIFVKSII G +A + G++++ND++I V+G SL K+N ++
Sbjct: 465 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 524
Query: 266 EILRNT 271
E LR +
Sbjct: 525 ETLRRS 530
Score = 52.4 bits (120), Expect = 5e-06
Identities = 37/114 (32%), Positives = 60/114 (52%), Gaps = 10/114 (8%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 327 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 386
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPADP--ATALRAPQPGTALVPTKILADPE 117
+ E+V ++LR + V LLV R D L A +P +P + A+ E
Sbjct: 387 KSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNA-EPSQMQIPKETKAEDE 439
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 327 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 385
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 386 GKSQEEVVSLLRSTKMEGTVSLLVFR 411
Score = 48.8 bits (111), Expect = 6e-05
Identities = 39/131 (29%), Positives = 64/131 (48%), Gaps = 16/131 (12%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L++ G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 456 VPLSDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 515
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 516 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 575
Query: 117 ELLDRHLIETG 127
E H + +G
Sbjct: 576 ERRISHSLYSG 586
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 465 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 524
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 525 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 560
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 331 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 387
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 388 SQEEVVSLLR 397
>AF467006-1|AAL76046.1| 1310|Homo sapiens partitioning-defective 3
protein splice variant f protein.
Length = 1310
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 272 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 332 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 391
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 392 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 442
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 443 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 502
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 503 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 534
Score = 60.1 bits (139), Expect = 2e-08
Identities = 37/102 (36%), Positives = 57/102 (55%), Gaps = 3/102 (2%)
Query: 172 HPIVCDSVSPTITITVPVELPEIEIIHVDLNKN-VYGLGITVAGYVCEKEELS-GIFVKS 229
HP + I +T P E V LN + GLG++V G ++ GIFVKS
Sbjct: 552 HPRELKAEDEDIVLT-PDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKS 610
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
II G +A + G++++ND++I V+G SL K+N ++E LR +
Sbjct: 611 IINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRS 652
Score = 51.6 bits (118), Expect = 9e-06
Identities = 31/88 (35%), Positives = 50/88 (56%), Gaps = 7/88 (7%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 462 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPAD 93
+ E+V ++LR + V LLV R D
Sbjct: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQED 549
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 462 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 521 GKSQEEVVSLLRSTKMEGTVSLLVFR 546
Score = 48.4 bits (110), Expect = 8e-05
Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 16/131 (12%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 578 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 637
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 638 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 697
Query: 117 ELLDRHLIETG 127
E H + +G
Sbjct: 698 ERRISHSLYSG 708
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 587 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 646
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 647 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 682
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 466 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 522
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 523 SQEEVVSLLR 532
>AF467005-1|AAL76045.1| 1244|Homo sapiens partitioning-defective 3
protein splice variant e protein.
Length = 1244
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 228 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 287
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 288 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 347
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 348 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 398
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 399 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 458
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 459 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 490
Score = 60.1 bits (139), Expect = 2e-08
Identities = 37/102 (36%), Positives = 57/102 (55%), Gaps = 3/102 (2%)
Query: 172 HPIVCDSVSPTITITVPVELPEIEIIHVDLNKN-VYGLGITVAGYVCEKEELS-GIFVKS 229
HP + I +T P E V LN + GLG++V G ++ GIFVKS
Sbjct: 508 HPRELKAEDEDIVLT-PDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKS 566
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
II G +A + G++++ND++I V+G SL K+N ++E LR +
Sbjct: 567 IINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRS 608
Score = 51.6 bits (118), Expect = 9e-06
Identities = 31/88 (35%), Positives = 50/88 (56%), Gaps = 7/88 (7%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 418 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 477
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPAD 93
+ E+V ++LR + V LLV R D
Sbjct: 478 KSQEEVVSLLRSTKMEGTVSLLVFRQED 505
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 418 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 476
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 477 GKSQEEVVSLLRSTKMEGTVSLLVFR 502
Score = 48.4 bits (110), Expect = 8e-05
Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 16/131 (12%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 534 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 593
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 594 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 653
Query: 117 ELLDRHLIETG 127
E H + +G
Sbjct: 654 ERRISHSLYSG 664
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 543 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 602
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 603 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 638
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 422 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 478
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 479 SQEEVVSLLR 488
>AF467004-1|AAL76044.1| 1319|Homo sapiens partitioning-defective 3
protein splice variant d protein.
Length = 1319
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 272 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 332 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 391
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 392 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 442
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 443 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 502
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 503 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 534
Score = 58.8 bits (136), Expect = 6e-08
Identities = 28/66 (42%), Positives = 45/66 (68%), Gaps = 1/66 (1%)
Query: 207 GLGITVAGYVCEKEELS-GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSV 265
GLG++V G ++ GIFVKSII G +A + G++++ND++I V+G SL K+N ++
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 266 EILRNT 271
E LR +
Sbjct: 660 ETLRRS 665
Score = 52.4 bits (120), Expect = 5e-06
Identities = 37/114 (32%), Positives = 60/114 (52%), Gaps = 10/114 (8%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 462 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPADP--ATALRAPQPGTALVPTKILADPE 117
+ E+V ++LR + V LLV R D L A +P +P + A+ E
Sbjct: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNA-EPSQMQIPKETKAEDE 574
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 462 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 521 GKSQEEVVSLLRSTKMEGTVSLLVFR 546
Score = 48.8 bits (111), Expect = 6e-05
Identities = 45/158 (28%), Positives = 75/158 (47%), Gaps = 17/158 (10%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 591 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 650
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 651 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 710
Query: 117 ELLDRHLIETGY-GAVYDLSQCYSDYNINGQNGETETS 153
E H + +G G S+ + I G++G+ + S
Sbjct: 711 ERRISHSLYSGIEGLDESPSRNAALSRIMGESGKYQLS 748
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 660 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 695
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 466 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 522
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 523 SQEEVVSLLR 532
>AF467003-1|AAL76043.1| 1353|Homo sapiens partitioning-defective 3
protein splice variant b protein.
Length = 1353
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 272 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 332 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 391
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 392 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 442
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 443 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 502
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 503 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 534
Score = 58.8 bits (136), Expect = 6e-08
Identities = 28/66 (42%), Positives = 45/66 (68%), Gaps = 1/66 (1%)
Query: 207 GLGITVAGYVCEKEELS-GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSV 265
GLG++V G ++ GIFVKSII G +A + G++++ND++I V+G SL K+N ++
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 266 EILRNT 271
E LR +
Sbjct: 660 ETLRRS 665
Score = 52.4 bits (120), Expect = 5e-06
Identities = 37/114 (32%), Positives = 60/114 (52%), Gaps = 10/114 (8%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 462 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPADP--ATALRAPQPGTALVPTKILADPE 117
+ E+V ++LR + V LLV R D L A +P +P + A+ E
Sbjct: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNA-EPSQMQIPKETKAEDE 574
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 462 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 521 GKSQEEVVSLLRSTKMEGTVSLLVFR 546
Score = 48.4 bits (110), Expect = 8e-05
Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 16/131 (12%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 591 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 650
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 651 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 710
Query: 117 ELLDRHLIETG 127
E H + +G
Sbjct: 711 ERRISHSLYSG 721
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 660 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 695
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 466 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 522
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 523 SQEEVVSLLR 532
>AF467002-1|AAL76042.1| 1356|Homo sapiens partitioning-defective 3
protein splice variant a protein.
Length = 1356
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 272 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 332 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 391
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 392 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 442
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 443 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 502
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 503 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 534
Score = 58.8 bits (136), Expect = 6e-08
Identities = 28/66 (42%), Positives = 45/66 (68%), Gaps = 1/66 (1%)
Query: 207 GLGITVAGYVCEKEELS-GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSV 265
GLG++V G ++ GIFVKSII G +A + G++++ND++I V+G SL K+N ++
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 266 EILRNT 271
E LR +
Sbjct: 660 ETLRRS 665
Score = 52.4 bits (120), Expect = 5e-06
Identities = 37/114 (32%), Positives = 60/114 (52%), Gaps = 10/114 (8%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 462 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPADP--ATALRAPQPGTALVPTKILADPE 117
+ E+V ++LR + V LLV R D L A +P +P + A+ E
Sbjct: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNA-EPSQMQIPKETKAEDE 574
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 462 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 521 GKSQEEVVSLLRSTKMEGTVSLLVFR 546
Score = 48.8 bits (111), Expect = 6e-05
Identities = 45/158 (28%), Positives = 75/158 (47%), Gaps = 17/158 (10%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 591 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 650
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 651 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 710
Query: 117 ELLDRHLIETGY-GAVYDLSQCYSDYNINGQNGETETS 153
E H + +G G S+ + I G++G+ + S
Sbjct: 711 ERRISHSLYSGIEGLDESPSRNAALSRIMGESGKYQLS 748
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 660 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 695
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 466 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 522
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 523 SQEEVVSLLR 532
>AF454059-1|AAN75699.1| 747|Homo sapiens SE2-5T2 protein protein.
Length = 747
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 2 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINEGD 61
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 62 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 121
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 122 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 172
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 173 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 232
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 233 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 264
Score = 60.1 bits (139), Expect = 2e-08
Identities = 37/102 (36%), Positives = 57/102 (55%), Gaps = 3/102 (2%)
Query: 172 HPIVCDSVSPTITITVPVELPEIEIIHVDLNKN-VYGLGITVAGYVCEKEELS-GIFVKS 229
HP + I +T P E V LN + GLG++V G ++ GIFVKS
Sbjct: 282 HPRELKAEDEDIVLT-PDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKS 340
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
II G +A + G++++ND++I V+G SL K+N ++E LR +
Sbjct: 341 IINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRS 382
Score = 51.6 bits (118), Expect = 9e-06
Identities = 31/88 (35%), Positives = 50/88 (56%), Gaps = 7/88 (7%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 192 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 251
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPAD 93
+ E+V ++LR + V LLV R D
Sbjct: 252 KSQEEVVSLLRSTKMEGTVSLLVFRQED 279
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 192 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 250
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 251 GKSQEEVVSLLRSTKMEGTVSLLVFR 276
Score = 48.4 bits (110), Expect = 8e-05
Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 16/131 (12%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 308 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 367
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 368 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 427
Query: 117 ELLDRHLIETG 127
E H + +G
Sbjct: 428 ERRISHSLYSG 438
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 317 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 376
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 377 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 412
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 196 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 252
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 253 SQEEVVSLLR 262
>AF454058-1|AAN75698.1| 943|Homo sapiens SE2-5L16 protein protein.
Length = 943
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 228 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 287
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 288 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 347
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 348 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 398
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 399 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 458
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 459 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 490
Score = 60.1 bits (139), Expect = 2e-08
Identities = 37/102 (36%), Positives = 57/102 (55%), Gaps = 3/102 (2%)
Query: 172 HPIVCDSVSPTITITVPVELPEIEIIHVDLNKN-VYGLGITVAGYVCEKEELS-GIFVKS 229
HP + I +T P E V LN + GLG++V G ++ GIFVKS
Sbjct: 508 HPRELKAEDEDIVLT-PDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKS 566
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
II G +A + G++++ND++I V+G SL K+N ++E LR +
Sbjct: 567 IINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRS 608
Score = 51.6 bits (118), Expect = 9e-06
Identities = 31/88 (35%), Positives = 50/88 (56%), Gaps = 7/88 (7%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 418 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 477
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPAD 93
+ E+V ++LR + V LLV R D
Sbjct: 478 KSQEEVVSLLRSTKMEGTVSLLVFRQED 505
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 418 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 476
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 477 GKSQEEVVSLLRSTKMEGTVSLLVFR 502
Score = 48.8 bits (111), Expect = 6e-05
Identities = 45/158 (28%), Positives = 75/158 (47%), Gaps = 17/158 (10%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 534 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 593
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 594 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 653
Query: 117 ELLDRHLIETGY-GAVYDLSQCYSDYNINGQNGETETS 153
E H + +G G S+ + I G++G+ + S
Sbjct: 654 ERRISHSLYSGIEGLDESPSRNAALSRIMGESGKYQLS 691
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 543 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 602
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 603 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 638
Score = 44.8 bits (101), Expect = 0.001
Identities = 32/92 (34%), Positives = 45/92 (48%), Gaps = 5/92 (5%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 422 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 478
Query: 450 THSEVVNILK--QLPDRVRLVCARNSIDSGPR 479
+ EVV++L+ ++ V L+ R PR
Sbjct: 479 SQEEVVSLLRSTKMEGTVSLLVFRQEDTFHPR 510
>AF454057-1|AAN75697.1| 819|Homo sapiens SE2-5LT1 protein protein.
Length = 819
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 93 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 152
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 153 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 212
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 213 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 263
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 264 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 323
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 324 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 355
Score = 58.8 bits (136), Expect = 6e-08
Identities = 28/66 (42%), Positives = 45/66 (68%), Gaps = 1/66 (1%)
Query: 207 GLGITVAGYVCEKEELS-GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSV 265
GLG++V G ++ GIFVKSII G +A + G++++ND++I V+G SL K+N ++
Sbjct: 421 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 480
Query: 266 EILRNT 271
E LR +
Sbjct: 481 ETLRRS 486
Score = 52.4 bits (120), Expect = 5e-06
Identities = 37/114 (32%), Positives = 60/114 (52%), Gaps = 10/114 (8%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 283 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 342
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPADP--ATALRAPQPGTALVPTKILADPE 117
+ E+V ++LR + V LLV R D L A +P +P + A+ E
Sbjct: 343 KSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNA-EPSQMQIPKETKAEDE 395
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 283 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 341
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 342 GKSQEEVVSLLRSTKMEGTVSLLVFR 367
Score = 48.4 bits (110), Expect = 8e-05
Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 16/131 (12%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 412 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 471
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 472 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 531
Query: 117 ELLDRHLIETG 127
E H + +G
Sbjct: 532 ERRISHSLYSG 542
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 421 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 480
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 481 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 516
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 287 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 343
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 344 SQEEVVSLLR 353
>AF332593-1|AAK69193.1| 1273|Homo sapiens atypical PKC
isotype-specific interacting protein long variant b
protein.
Length = 1273
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 272 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 332 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 391
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 392 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 442
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 443 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 502
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 503 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 534
Score = 60.1 bits (139), Expect = 2e-08
Identities = 37/102 (36%), Positives = 57/102 (55%), Gaps = 3/102 (2%)
Query: 172 HPIVCDSVSPTITITVPVELPEIEIIHVDLNKN-VYGLGITVAGYVCEKEELS-GIFVKS 229
HP + I +T P E V LN + GLG++V G ++ GIFVKS
Sbjct: 552 HPRELKAEDEDIVLT-PDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKS 610
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
II G +A + G++++ND++I V+G SL K+N ++E LR +
Sbjct: 611 IINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRS 652
Score = 51.6 bits (118), Expect = 9e-06
Identities = 31/88 (35%), Positives = 50/88 (56%), Gaps = 7/88 (7%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 462 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPAD 93
+ E+V ++LR + V LLV R D
Sbjct: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQED 549
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 462 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 521 GKSQEEVVSLLRSTKMEGTVSLLVFR 546
Score = 48.4 bits (110), Expect = 8e-05
Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 16/131 (12%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 578 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 637
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 638 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 697
Query: 117 ELLDRHLIETG 127
E H + +G
Sbjct: 698 ERRISHSLYSG 708
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 587 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 646
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 647 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 682
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 466 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 522
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 523 SQEEVVSLLR 532
>AF332592-1|AAK69192.1| 988|Homo sapiens atypical PKC
isotype-specific interacting protein short variant b
protein.
Length = 988
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 272 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 332 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 391
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 392 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 442
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 443 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 502
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 503 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 534
Score = 60.1 bits (139), Expect = 2e-08
Identities = 37/102 (36%), Positives = 57/102 (55%), Gaps = 3/102 (2%)
Query: 172 HPIVCDSVSPTITITVPVELPEIEIIHVDLNKN-VYGLGITVAGYVCEKEELS-GIFVKS 229
HP + I +T P E V LN + GLG++V G ++ GIFVKS
Sbjct: 552 HPRELKAEDEDIVLT-PDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKS 610
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
II G +A + G++++ND++I V+G SL K+N ++E LR +
Sbjct: 611 IINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRS 652
Score = 51.6 bits (118), Expect = 9e-06
Identities = 31/88 (35%), Positives = 50/88 (56%), Gaps = 7/88 (7%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 462 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPAD 93
+ E+V ++LR + V LLV R D
Sbjct: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQED 549
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 462 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 521 GKSQEEVVSLLRSTKMEGTVSLLVFR 546
Score = 48.4 bits (110), Expect = 8e-05
Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 16/131 (12%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 578 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 637
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 638 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 697
Query: 117 ELLDRHLIETG 127
E H + +G
Sbjct: 698 ERRISHSLYSG 708
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 587 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 646
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 647 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 682
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 466 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 522
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 523 SQEEVVSLLR 532
>AF252293-1|AAF71530.1| 1266|Homo sapiens partitioning-defective 3
splice variant c protein.
Length = 1266
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 228 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 287
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 288 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 347
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 348 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 398
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 399 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 458
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 459 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 490
Score = 60.1 bits (139), Expect = 2e-08
Identities = 37/102 (36%), Positives = 57/102 (55%), Gaps = 3/102 (2%)
Query: 172 HPIVCDSVSPTITITVPVELPEIEIIHVDLNKN-VYGLGITVAGYVCEKEELS-GIFVKS 229
HP + I +T P E V LN + GLG++V G ++ GIFVKS
Sbjct: 508 HPRELKAEDEDIVLT-PDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKS 566
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
II G +A + G++++ND++I V+G SL K+N ++E LR +
Sbjct: 567 IINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRS 608
Score = 51.6 bits (118), Expect = 9e-06
Identities = 31/88 (35%), Positives = 50/88 (56%), Gaps = 7/88 (7%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 418 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 477
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPAD 93
+ E+V ++LR + V LLV R D
Sbjct: 478 KSQEEVVSLLRSTKMEGTVSLLVFRQED 505
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 418 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 476
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 477 GKSQEEVVSLLRSTKMEGTVSLLVFR 502
Score = 48.4 bits (110), Expect = 8e-05
Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 16/131 (12%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 534 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 593
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 594 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 653
Query: 117 ELLDRHLIETG 127
E H + +G
Sbjct: 654 ERRISHSLYSG 664
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 543 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 602
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 603 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 638
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 422 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 478
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 479 SQEEVVSLLR 488
>AF196186-1|AAK27892.1| 1031|Homo sapiens atypical PKC
isotype-specific interacting protein short variant
protein.
Length = 1031
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 272 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 332 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 391
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 392 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 442
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 443 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 502
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 503 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 534
Score = 58.8 bits (136), Expect = 6e-08
Identities = 28/66 (42%), Positives = 45/66 (68%), Gaps = 1/66 (1%)
Query: 207 GLGITVAGYVCEKEELS-GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSV 265
GLG++V G ++ GIFVKSII G +A + G++++ND++I V+G SL K+N ++
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 266 EILRNT 271
E LR +
Sbjct: 660 ETLRRS 665
Score = 52.4 bits (120), Expect = 5e-06
Identities = 37/114 (32%), Positives = 60/114 (52%), Gaps = 10/114 (8%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 462 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPADP--ATALRAPQPGTALVPTKILADPE 117
+ E+V ++LR + V LLV R D L A +P +P + A+ E
Sbjct: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNA-EPSQMQIPKETKAEDE 574
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 462 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 521 GKSQEEVVSLLRSTKMEGTVSLLVFR 546
Score = 48.4 bits (110), Expect = 8e-05
Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 16/131 (12%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 591 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 650
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 651 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 710
Query: 117 ELLDRHLIETG 127
E H + +G
Sbjct: 711 ERRISHSLYSG 721
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 660 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 695
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 466 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 522
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 523 SQEEVVSLLR 532
>AF196185-1|AAK27891.1| 1353|Homo sapiens atypical PKC
isotype-specific interacting protein long variant
protein.
Length = 1353
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 272 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 332 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 391
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 392 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 442
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 443 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 502
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 503 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 534
Score = 58.8 bits (136), Expect = 6e-08
Identities = 28/66 (42%), Positives = 45/66 (68%), Gaps = 1/66 (1%)
Query: 207 GLGITVAGYVCEKEELS-GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSV 265
GLG++V G ++ GIFVKSII G +A + G++++ND++I V+G SL K+N ++
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 266 EILRNT 271
E LR +
Sbjct: 660 ETLRRS 665
Score = 52.4 bits (120), Expect = 5e-06
Identities = 37/114 (32%), Positives = 60/114 (52%), Gaps = 10/114 (8%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 462 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPADP--ATALRAPQPGTALVPTKILADPE 117
+ E+V ++LR + V LLV R D L A +P +P + A+ E
Sbjct: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNA-EPSQMQIPKETKAEDE 574
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 462 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 521 GKSQEEVVSLLRSTKMEGTVSLLVFR 546
Score = 48.4 bits (110), Expect = 8e-05
Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 16/131 (12%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 591 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 650
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 651 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 710
Query: 117 ELLDRHLIETG 127
E H + +G
Sbjct: 711 ERRISHSLYSG 721
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 660 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 695
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 466 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 522
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 523 SQEEVVSLLR 532
>AB073671-1|BAC54037.1| 1244|Homo sapiens PAR3 protein.
Length = 1244
Score = 73.7 bits (173), Expect = 2e-12
Identities = 67/272 (24%), Positives = 126/272 (46%), Gaps = 19/272 (6%)
Query: 10 VEVVELTNDGNGLGFNLV-----GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V++VE+ NDG LG ++V GGR+ G+++K + GG A+ + + D ++++ +
Sbjct: 228 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 287
Query: 65 LRGFTSEQVAAVLRQA--GPVVRLLVARPADPATALRAPQPG-TALVPTKILADPELLDR 121
LR EQ + RQA P++ V A+ + Q ++ D + +D
Sbjct: 288 LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 347
Query: 122 HLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQ-KIPDHPIVCDSVS 180
+ + A Q N + ++ + + +A +P K P P
Sbjct: 348 RSVNS---AGLHTVQRAPRLNHPPEQIDSHSRLPHSA------HPSGKPPSAPASAPQNV 398
Query: 181 PTITITVPVELPEI-EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQS 239
+ T++ +I + +++ L K GLG ++ + I+VK+I+ +A Q
Sbjct: 399 FSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQD 458
Query: 240 GKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
G++K DR+IEV+G+ L KS + V +LR+T
Sbjct: 459 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 490
Score = 60.1 bits (139), Expect = 2e-08
Identities = 37/102 (36%), Positives = 57/102 (55%), Gaps = 3/102 (2%)
Query: 172 HPIVCDSVSPTITITVPVELPEIEIIHVDLNKN-VYGLGITVAGYVCEKEELS-GIFVKS 229
HP + I +T P E V LN + GLG++V G ++ GIFVKS
Sbjct: 508 HPRELKAEDEDIVLT-PDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKS 566
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
II G +A + G++++ND++I V+G SL K+N ++E LR +
Sbjct: 567 IINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRS 608
Score = 51.6 bits (118), Expect = 9e-06
Identities = 31/88 (35%), Positives = 50/88 (56%), Gaps = 7/88 (7%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 418 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 477
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPAD 93
+ E+V ++LR + V LLV R D
Sbjct: 478 KSQEEVVSLLRSTKMEGTVSLLVFRQED 505
Score = 51.2 bits (117), Expect = 1e-05
Identities = 28/86 (32%), Positives = 47/86 (54%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GLGFSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 418 IQLKKGTEGLGFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 476
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 477 GKSQEEVVSLLRSTKMEGTVSLLVFR 502
Score = 48.4 bits (110), Expect = 8e-05
Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 16/131 (12%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 534 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 593
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 594 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 653
Query: 117 ELLDRHLIETG 127
E H + +G
Sbjct: 654 ERRISHSLYSG 664
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 543 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 602
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 603 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 638
Score = 44.4 bits (100), Expect = 0.001
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGLG S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 422 KGTEGLGFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 478
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 479 SQEEVVSLLR 488
>AL353639-1|CAI41236.1| 611|Homo sapiens multiple PDZ domain
protein protein.
Length = 611
Score = 73.3 bits (172), Expect = 2e-12
Identities = 115/491 (23%), Positives = 199/491 (40%), Gaps = 74/491 (15%)
Query: 181 PTITIT-VPVELPEIEII-HVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQ 238
PT+T + V+L + + H++L K+ GLGI ++ E++ LSG+ +KS+ E A
Sbjct: 33 PTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAIS----EEDTLSGVIIKSLTEHGVAAT 88
Query: 239 SGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHLQLAIFNE 298
G++K+ D+I+ VD + + + +L+ ++V L + + +
Sbjct: 89 DGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASG 148
Query: 299 ERXXXXXXXXXXLSWFPVPSQLENSITEIEPE------------PESNTTIDSSVLEVG- 345
E+ S P P + N+ P P TTI+ S G
Sbjct: 149 EKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGL 208
Query: 346 ----------------DLQEPTQEE----LDQRFDEILAVDKEDIVKKWKEEIGSDKEIL 385
DL++ T +E L Q + D +EE+ D +
Sbjct: 209 GLSIVGGSDTLLVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEV-CDTLTI 267
Query: 386 VAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYR 445
+ K +GLG+S+ G + G ++ ++ G G L GD++L VN
Sbjct: 268 ELQKKPGKGLGLSIVGKRNDTG-------VFVSDIVKGGIADADGRLMQGDQILMVNGED 320
Query: 446 LHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLT 505
+ T V +LK V L R I +GP S+R ++ ++ GSL++ T
Sbjct: 321 VRNATQEAVAALLKCSLGTVTLEVGR--IKAGP-----FHSERRPSQSSQVSEGSLSSFT 373
Query: 506 TLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFS 565
S ++T + SKK+ + GL + K+ LG S
Sbjct: 374 ----------FPLSGSSTSESLESSSKKNALASEIQGLRTVEMKKG------PTDSLGIS 417
Query: 566 ILDYQDPVDPNGTV-IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
I P G V I + + P GVA + ++ GDR++++ G S + T QAV LK
Sbjct: 418 IAG--GVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLK 475
Query: 625 GAPRGTVKVGI 635
A G++++ +
Sbjct: 476 NA-SGSIEMQV 485
Score = 62.1 bits (144), Expect = 6e-09
Identities = 36/85 (42%), Positives = 50/85 (58%), Gaps = 2/85 (2%)
Query: 19 GNGLGFNLVGGRS-TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAVL 77
G GLG ++VG R+ TGV + ++ GG+AD D RL GD +L V ++R T E VAA+L
Sbjct: 274 GKGLGLSIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALL 333
Query: 78 RQAGPVVRLLVAR-PADPATALRAP 101
+ + V L V R A P + R P
Sbjct: 334 KCSLGTVTLEVGRIKAGPFHSERRP 358
Score = 55.6 bits (128), Expect = 5e-07
Identities = 77/312 (24%), Positives = 144/312 (46%), Gaps = 35/312 (11%)
Query: 5 TEWAQVEVVELTNDGNGLGFNLVGGRS-TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSV 63
+ + V+ +EL D GLG + + +GV+IK + GVA D RL+ GD +L V
Sbjct: 45 SSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDE 104
Query: 64 NLRGFTSEQVAAVLRQAGPVVRLLV--------ARP--ADPATALRAPQPGTALVPTKIL 113
+ G+ E+ ++L+ A V+L + A P A A+ + + +VP
Sbjct: 105 IVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSLMVPQSGS 164
Query: 114 ADPELLDRHLIETGYGAVY--DLSQC----YSDYNINGQNGET--ETSIVAAAVSVI--G 163
+PE + R+ + A++ D + C + I G T SIV + +++ G
Sbjct: 165 PEPESI-RNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLVNG 223
Query: 164 DNPQKIP-DHPI-VCDSVSPTITITV-----PVELPEI-EIIHVDLNKNV-YGLGITVAG 214
+ +K D I V + +T+ P + E+ + + ++L K GLG+++ G
Sbjct: 224 IDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVG 283
Query: 215 YVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGIS 274
K +G+FV I++G A+ G++ D+I+ V+G + + + +L+ + +
Sbjct: 284 ----KRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKCSLGT 339
Query: 275 VHLVLERYLRGP 286
V L + R GP
Sbjct: 340 VTLEVGRIKAGP 351
Score = 53.2 bits (122), Expect = 3e-06
Identities = 30/81 (37%), Positives = 47/81 (58%), Gaps = 6/81 (7%)
Query: 557 KADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATL 616
K +GLG SI+ + N T + V +V GG+A+ +G + GD+++ VNG ++NAT
Sbjct: 272 KPGKGLGLSIVGKR-----NDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNAT- 325
Query: 617 DQAVQALKGAPRGTVKVGIAR 637
+AV AL GTV + + R
Sbjct: 326 QEAVAALLKCSLGTVTLEVGR 346
Score = 52.4 bits (120), Expect = 5e-06
Identities = 28/85 (32%), Positives = 46/85 (54%), Gaps = 5/85 (5%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDHVLQVGSV 63
Q + + L +GLGF++VGG + + +K V G A +D RL+ GD ++ V
Sbjct: 525 QCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQ 584
Query: 64 NLRGFTSEQVAAVLRQAGPVVRLLV 88
+L G T E+ A+L++ V L+V
Sbjct: 585 SLEGVTHEEAVAILKRTKGTVTLMV 609
Score = 52.0 bits (119), Expect = 6e-06
Identities = 43/170 (25%), Positives = 82/170 (48%), Gaps = 17/170 (10%)
Query: 463 DRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTSSTA 522
DR+ +C ++ VNL + G ++++G +++ + Q + + ++ S
Sbjct: 452 DRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGG--DVSVVTGHQQEPASSSLSFT 509
Query: 523 TLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTV-IV 581
LT+ S +C S + L + GLGFSI+ P+G + I
Sbjct: 510 GLTSSSIFQDDLGPPQCKS-----------ITLERGPDGLGFSIVGGYG--SPHGDLPIY 556
Query: 582 VRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTV 631
V+++ G A ++G + GD++++VNG S++ T ++AV LK +GTV
Sbjct: 557 VKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILK-RTKGTV 605
Score = 46.4 bits (105), Expect = 3e-04
Identities = 35/138 (25%), Positives = 69/138 (50%), Gaps = 3/138 (2%)
Query: 143 INGQNGETETSIVAAA-VSVIGDNPQKIPDHPIVCDSVSPTITITVPVELPEIEIIHVDL 201
+ +G E +VA VSV+ + Q+ + ++ + + P+ + I ++
Sbjct: 474 LKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKSITLER 533
Query: 202 NKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSN 261
+ G I V GY +L I+VK++ +A + G++K D+II V+G SL ++
Sbjct: 534 GPDGLGFSI-VGGYGSPHGDLP-IYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTH 591
Query: 262 PQSVEILRNTGISVHLVL 279
++V IL+ T +V L++
Sbjct: 592 EEAVAILKRTKGTVTLMV 609
Score = 43.6 bits (98), Expect = 0.002
Identities = 27/76 (35%), Positives = 38/76 (50%), Gaps = 3/76 (3%)
Query: 393 EGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHS 452
+GLG S+ G G P Y+++V G G L GD+++ VN L G+TH
Sbjct: 536 DGLGFSIVGGYGSPHGD--LPI-YVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHE 592
Query: 453 EVVNILKQLPDRVRLV 468
E V ILK+ V L+
Sbjct: 593 EAVAILKRTKGTVTLM 608
Score = 34.7 bits (76), Expect = 1.0
Identities = 25/93 (26%), Positives = 48/93 (51%), Gaps = 6/93 (6%)
Query: 555 LVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNA 614
L K GLG +I + +D + ++++SL GVA +G + GD++++V+ +
Sbjct: 55 LPKDQGGLGIAISE-EDTLSG----VIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGY 109
Query: 615 TLDQAVQALKGAPRGTVKVGIARPLPPQDSSKS 647
+++ + LK A + TVK+ I P + S
Sbjct: 110 PIEKFISLLKTA-KMTVKLTIHAENPDSQAVPS 141
Score = 33.9 bits (74), Expect = 1.8
Identities = 23/97 (23%), Positives = 45/97 (46%), Gaps = 6/97 (6%)
Query: 3 LSTEWAQVEVVELTNDG-NGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDH 56
L++E + VE+ + LG ++ GG + + I + P GVA + ++L+ GD
Sbjct: 394 LASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDR 453
Query: 57 VLQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVARPAD 93
++ + + G T Q +L+ A + + V D
Sbjct: 454 IVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGD 490
>AL161449-1|CAI40490.1| 611|Homo sapiens multiple PDZ domain
protein protein.
Length = 611
Score = 73.3 bits (172), Expect = 2e-12
Identities = 115/491 (23%), Positives = 199/491 (40%), Gaps = 74/491 (15%)
Query: 181 PTITIT-VPVELPEIEII-HVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQ 238
PT+T + V+L + + H++L K+ GLGI ++ E++ LSG+ +KS+ E A
Sbjct: 33 PTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAIS----EEDTLSGVIIKSLTEHGVAAT 88
Query: 239 SGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHLQLAIFNE 298
G++K+ D+I+ VD + + + +L+ ++V L + + +
Sbjct: 89 DGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASG 148
Query: 299 ERXXXXXXXXXXLSWFPVPSQLENSITEIEPE------------PESNTTIDSSVLEVG- 345
E+ S P P + N+ P P TTI+ S G
Sbjct: 149 EKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGL 208
Query: 346 ----------------DLQEPTQEE----LDQRFDEILAVDKEDIVKKWKEEIGSDKEIL 385
DL++ T +E L Q + D +EE+ D +
Sbjct: 209 GLSIVGGSDTLLVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEV-CDTLTI 267
Query: 386 VAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYR 445
+ K +GLG+S+ G + G ++ ++ G G L GD++L VN
Sbjct: 268 ELQKKPGKGLGLSIVGKRNDTG-------VFVSDIVKGGIADADGRLMQGDQILMVNGED 320
Query: 446 LHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLT 505
+ T V +LK V L R I +GP S+R ++ ++ GSL++ T
Sbjct: 321 VRNATQEAVAALLKCSLGTVTLEVGR--IKAGP-----FHSERRPSQSSQVSEGSLSSFT 373
Query: 506 TLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFS 565
S ++T + SKK+ + GL + K+ LG S
Sbjct: 374 ----------FPLSGSSTSESLESSSKKNALASEIQGLRTVEMKKG------PTDSLGIS 417
Query: 566 ILDYQDPVDPNGTV-IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
I P G V I + + P GVA + ++ GDR++++ G S + T QAV LK
Sbjct: 418 IAG--GVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLK 475
Query: 625 GAPRGTVKVGI 635
A G++++ +
Sbjct: 476 NA-SGSIEMQV 485
Score = 62.1 bits (144), Expect = 6e-09
Identities = 36/85 (42%), Positives = 50/85 (58%), Gaps = 2/85 (2%)
Query: 19 GNGLGFNLVGGRS-TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAVL 77
G GLG ++VG R+ TGV + ++ GG+AD D RL GD +L V ++R T E VAA+L
Sbjct: 274 GKGLGLSIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALL 333
Query: 78 RQAGPVVRLLVAR-PADPATALRAP 101
+ + V L V R A P + R P
Sbjct: 334 KCSLGTVTLEVGRIKAGPFHSERRP 358
Score = 55.6 bits (128), Expect = 5e-07
Identities = 77/312 (24%), Positives = 144/312 (46%), Gaps = 35/312 (11%)
Query: 5 TEWAQVEVVELTNDGNGLGFNLVGGRS-TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSV 63
+ + V+ +EL D GLG + + +GV+IK + GVA D RL+ GD +L V
Sbjct: 45 SSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDE 104
Query: 64 NLRGFTSEQVAAVLRQAGPVVRLLV--------ARP--ADPATALRAPQPGTALVPTKIL 113
+ G+ E+ ++L+ A V+L + A P A A+ + + +VP
Sbjct: 105 IVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSLMVPQSGS 164
Query: 114 ADPELLDRHLIETGYGAVY--DLSQC----YSDYNINGQNGET--ETSIVAAAVSVI--G 163
+PE + R+ + A++ D + C + I G T SIV + +++ G
Sbjct: 165 PEPESI-RNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLVNG 223
Query: 164 DNPQKIP-DHPI-VCDSVSPTITITV-----PVELPEI-EIIHVDLNKNV-YGLGITVAG 214
+ +K D I V + +T+ P + E+ + + ++L K GLG+++ G
Sbjct: 224 IDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVG 283
Query: 215 YVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGIS 274
K +G+FV I++G A+ G++ D+I+ V+G + + + +L+ + +
Sbjct: 284 ----KRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKCSLGT 339
Query: 275 VHLVLERYLRGP 286
V L + R GP
Sbjct: 340 VTLEVGRIKAGP 351
Score = 53.2 bits (122), Expect = 3e-06
Identities = 30/81 (37%), Positives = 47/81 (58%), Gaps = 6/81 (7%)
Query: 557 KADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATL 616
K +GLG SI+ + N T + V +V GG+A+ +G + GD+++ VNG ++NAT
Sbjct: 272 KPGKGLGLSIVGKR-----NDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNAT- 325
Query: 617 DQAVQALKGAPRGTVKVGIAR 637
+AV AL GTV + + R
Sbjct: 326 QEAVAALLKCSLGTVTLEVGR 346
Score = 52.4 bits (120), Expect = 5e-06
Identities = 28/85 (32%), Positives = 46/85 (54%), Gaps = 5/85 (5%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDHVLQVGSV 63
Q + + L +GLGF++VGG + + +K V G A +D RL+ GD ++ V
Sbjct: 525 QCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQ 584
Query: 64 NLRGFTSEQVAAVLRQAGPVVRLLV 88
+L G T E+ A+L++ V L+V
Sbjct: 585 SLEGVTHEEAVAILKRTKGTVTLMV 609
Score = 52.0 bits (119), Expect = 6e-06
Identities = 43/170 (25%), Positives = 82/170 (48%), Gaps = 17/170 (10%)
Query: 463 DRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTSSTA 522
DR+ +C ++ VNL + G ++++G +++ + Q + + ++ S
Sbjct: 452 DRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGG--DVSVVTGHQQEPASSSLSFT 509
Query: 523 TLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTV-IV 581
LT+ S +C S + L + GLGFSI+ P+G + I
Sbjct: 510 GLTSSSIFQDDLGPPQCKS-----------ITLERGPDGLGFSIVGGYG--SPHGDLPIY 556
Query: 582 VRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTV 631
V+++ G A ++G + GD++++VNG S++ T ++AV LK +GTV
Sbjct: 557 VKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILK-RTKGTV 605
Score = 46.4 bits (105), Expect = 3e-04
Identities = 35/138 (25%), Positives = 69/138 (50%), Gaps = 3/138 (2%)
Query: 143 INGQNGETETSIVAAA-VSVIGDNPQKIPDHPIVCDSVSPTITITVPVELPEIEIIHVDL 201
+ +G E +VA VSV+ + Q+ + ++ + + P+ + I ++
Sbjct: 474 LKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKSITLER 533
Query: 202 NKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSN 261
+ G I V GY +L I+VK++ +A + G++K D+II V+G SL ++
Sbjct: 534 GPDGLGFSI-VGGYGSPHGDLP-IYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTH 591
Query: 262 PQSVEILRNTGISVHLVL 279
++V IL+ T +V L++
Sbjct: 592 EEAVAILKRTKGTVTLMV 609
Score = 43.6 bits (98), Expect = 0.002
Identities = 27/76 (35%), Positives = 38/76 (50%), Gaps = 3/76 (3%)
Query: 393 EGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHS 452
+GLG S+ G G P Y+++V G G L GD+++ VN L G+TH
Sbjct: 536 DGLGFSIVGGYGSPHGD--LPI-YVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHE 592
Query: 453 EVVNILKQLPDRVRLV 468
E V ILK+ V L+
Sbjct: 593 EAVAILKRTKGTVTLM 608
Score = 34.7 bits (76), Expect = 1.0
Identities = 25/93 (26%), Positives = 48/93 (51%), Gaps = 6/93 (6%)
Query: 555 LVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNA 614
L K GLG +I + +D + ++++SL GVA +G + GD++++V+ +
Sbjct: 55 LPKDQGGLGIAISE-EDTLSG----VIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGY 109
Query: 615 TLDQAVQALKGAPRGTVKVGIARPLPPQDSSKS 647
+++ + LK A + TVK+ I P + S
Sbjct: 110 PIEKFISLLKTA-KMTVKLTIHAENPDSQAVPS 141
Score = 33.9 bits (74), Expect = 1.8
Identities = 23/97 (23%), Positives = 45/97 (46%), Gaps = 6/97 (6%)
Query: 3 LSTEWAQVEVVELTNDG-NGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDH 56
L++E + VE+ + LG ++ GG + + I + P GVA + ++L+ GD
Sbjct: 394 LASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDR 453
Query: 57 VLQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVARPAD 93
++ + + G T Q +L+ A + + V D
Sbjct: 454 IVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGD 490
>AB002298-1|BAA20760.2| 2847|Homo sapiens KIAA0300 protein.
Length = 2847
Score = 72.5 bits (170), Expect = 4e-12
Identities = 70/261 (26%), Positives = 113/261 (43%), Gaps = 35/261 (13%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
+K +GLG S+ G D GQ +++++ P+G G L GDE+L+VN + GL
Sbjct: 600 EKGKGLGFSIAGGRDCIRGQM---GIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGL 656
Query: 450 THSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVK 509
T E ++ KQ+ + ++ R K++S SL +T
Sbjct: 657 TFQEAIHTFKQIRSGLFVLTVRT----------------------KLVSPSLTPCSTPTH 694
Query: 510 AQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQ----GLGFS 565
S N +++ + S SL G K+ IVM V ++ GLG
Sbjct: 695 MSRSASPNFNTSGGASAGGSDEGSSSSL----GRKTPGPKDRIVMEVTLNKEPRVGLGIG 750
Query: 566 ILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKG 625
P G I + SL PG VA+ +S GD+++ VN V++++A L + L
Sbjct: 751 ACCLALENSPPG--IYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSK 808
Query: 626 APRGTVKVGIARPLPPQDSSK 646
P G V++ I R P+ S +
Sbjct: 809 CPPGPVRLVIGRHPNPKVSEQ 829
Score = 55.2 bits (127), Expect = 7e-07
Identities = 33/98 (33%), Positives = 52/98 (53%), Gaps = 5/98 (5%)
Query: 6 EWAQVEVVELTNDGNGLGFNLVGGRST-----GVVIKYVLPGGVADKDRRLQSGDHVLQV 60
E ++ +EL + +GLG + GGR + +V+ V GG A +D RL GD +L +
Sbjct: 336 EVGRIWKMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVI 395
Query: 61 GSVNLRGFTSEQVAAVLRQAGPVVRLLVARPADPATAL 98
L G + E+ A+LR A +V+L+VA + A L
Sbjct: 396 NGHLLVGLSHEEAVAILRSATGMVQLVVASKENSAEDL 433
Score = 52.0 bits (119), Expect = 6e-06
Identities = 25/77 (32%), Positives = 41/77 (53%), Gaps = 5/77 (6%)
Query: 19 GNGLGFNLVGGRST-----GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQV 73
G GLGF++ GGR G+ +K + P G A +D RL+ GD +L V + ++G T ++
Sbjct: 602 GKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEA 661
Query: 74 AAVLRQAGPVVRLLVAR 90
+Q + +L R
Sbjct: 662 IHTFKQIRSGLFVLTVR 678
Score = 50.0 bits (114), Expect = 3e-05
Identities = 36/112 (32%), Positives = 59/112 (52%), Gaps = 9/112 (8%)
Query: 519 SSTATLTNHSEQSKKSRSLECVSGLAMWQ----SKEDIVMLVKAD-QGLGFSILDYQDPV 573
SS+A+ H + K +RSL + W+ S I+ L K +GLGFSI +D +
Sbjct: 558 SSSASQEYHIVK-KSTRSLSTTQVESPWRLIRPSVISIIGLYKEKGKGLGFSIAGGRDCI 616
Query: 574 DPNGTV-IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
G + I V+++ P G A ++G + GD ++ VNG+ I+ T +A+ K
Sbjct: 617 --RGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFK 666
Score = 48.4 bits (110), Expect = 8e-05
Identities = 37/109 (33%), Positives = 50/109 (45%), Gaps = 7/109 (6%)
Query: 373 KWKEEIGSDKEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVL 432
K + E D +V K+ GLG S+ G DVE + + H V G +G +
Sbjct: 2619 KAQSENEEDVCFIVLNRKEGSGLGFSVAGGTDVEP-KSITVHR----VFSQGAASQEGTM 2673
Query: 433 NAGDELLEVNEYRLHGLTHSEVVNILKQLP-DRVRLVCARNSIDSGPRP 480
N GD LL VN L GL H V+ +L Q + LV + +D PRP
Sbjct: 2674 NRGDFLLSVNGASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQ-PRP 2721
Score = 48.0 bits (109), Expect = 1e-04
Identities = 33/97 (34%), Positives = 54/97 (55%), Gaps = 7/97 (7%)
Query: 375 KEEIGSDKEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQ-GVLN 433
+EE+G ++ + +K+ +GLGI + G G + PH + + + +G + G L+
Sbjct: 334 REEVGRIWKMEL--LKESDGLGIQVSGG----RGSKRSPHAIVVTQVKEGGAAHRDGRLS 387
Query: 434 AGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCA 470
GDELL +N + L GL+H E V IL+ V+LV A
Sbjct: 388 LGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVVA 424
Score = 46.4 bits (105), Expect = 3e-04
Identities = 26/81 (32%), Positives = 44/81 (54%)
Query: 199 VDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLAD 258
++L K GLGI V+G K I V + EG +A + G++ + D ++ ++G L
Sbjct: 343 MELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVG 402
Query: 259 KSNPQSVEILRNTGISVHLVL 279
S+ ++V ILR+ V LV+
Sbjct: 403 LSHEEAVAILRSATGMVQLVV 423
Score = 46.0 bits (104), Expect = 4e-04
Identities = 24/63 (38%), Positives = 36/63 (57%), Gaps = 1/63 (1%)
Query: 33 GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAVLRQAGP-VVRLLVARP 91
G+ I + PG VA + L GD +L+V SVN+R +V A+L + P VRL++ R
Sbjct: 762 GIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRLVIGRH 821
Query: 92 ADP 94
+P
Sbjct: 822 PNP 824
Score = 46.0 bits (104), Expect = 4e-04
Identities = 29/81 (35%), Positives = 42/81 (51%), Gaps = 5/81 (6%)
Query: 384 ILVAEIKKLEGLGISLEG-TVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVN 442
+ V +K GLG+SL+G V G L I+ V G G++ AGDE+L +N
Sbjct: 2757 LCVEVLKTSAGLGLSLDGGKSSVTGDGPL----VIKRVYKGGAAEQAGIIEAGDEILAIN 2812
Query: 443 EYRLHGLTHSEVVNILKQLPD 463
L GL H + NI+K +P+
Sbjct: 2813 GKPLVGLMHFDAWNIMKSVPE 2833
Score = 45.6 bits (103), Expect = 6e-04
Identities = 30/107 (28%), Positives = 53/107 (49%), Gaps = 1/107 (0%)
Query: 531 SKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGV 590
S+K+ LE G ++ V ++K GLG S+ + V +G +++ R + GG
Sbjct: 2737 SRKTIPLEPGIGRSVAVHDALCVEVLKTSAGLGLSLDGGKSSVTGDGPLVIKR-VYKGGA 2795
Query: 591 AEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIAR 637
AE+ G I GD ++++NG + A +K P G V++ I +
Sbjct: 2796 AEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPEGPVQLLIRK 2842
Score = 41.5 bits (93), Expect = 0.009
Identities = 21/51 (41%), Positives = 34/51 (66%), Gaps = 2/51 (3%)
Query: 207 GLGITVAG-YVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISL 256
GLG ++AG C + ++ GIFVK+I SA + G++K D I++V+GI +
Sbjct: 604 GLGFSIAGGRDCIRGQM-GIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPI 653
Score = 40.3 bits (90), Expect = 0.021
Identities = 21/66 (31%), Positives = 32/66 (48%), Gaps = 3/66 (4%)
Query: 18 DGNGLGFNLVGGRST---GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVA 74
+G+GLGF++ GG + + V G A ++ + GD +L V +L G V
Sbjct: 2637 EGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNVL 2696
Query: 75 AVLRQA 80
VL QA
Sbjct: 2697 KVLHQA 2702
Score = 37.9 bits (84), Expect = 0.11
Identities = 24/82 (29%), Positives = 43/82 (52%), Gaps = 2/82 (2%)
Query: 555 LVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNA 614
L+K GLG + + + IVV + GG A ++G +S GD ++ +NG +
Sbjct: 345 LLKESDGLGIQVSGGRGS-KRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGL 403
Query: 615 TLDQAVQALKGAPRGTVKVGIA 636
+ ++AV L+ A G V++ +A
Sbjct: 404 SHEEAVAILRSA-TGMVQLVVA 424
Score = 37.5 bits (83), Expect = 0.15
Identities = 27/82 (32%), Positives = 42/82 (51%), Gaps = 7/82 (8%)
Query: 13 VELTNDGNGLGFNLVGGRS--TG---VVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
VE+ GLG +L GG+S TG +VIK V GG A++ +++GD +L + L G
Sbjct: 2759 VEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVG 2818
Query: 68 FTSEQVAAVLRQA--GPVVRLL 87
+++ GPV L+
Sbjct: 2819 LMHFDAWNIMKSVPEGPVQLLI 2840
Score = 33.1 bits (72), Expect = 3.2
Identities = 19/62 (30%), Positives = 32/62 (51%), Gaps = 2/62 (3%)
Query: 196 IIHVDLNKNV-YGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGI 254
++ V LNK GLGI E GI++ S+ GS A+ + D+I+EV+ +
Sbjct: 734 VMEVTLNKEPRVGLGIGACCLALENSP-PGIYIHSLAPGSVAKMESNLSRGDQILEVNSV 792
Query: 255 SL 256
++
Sbjct: 793 NV 794
Score = 31.9 bits (69), Expect = 7.4
Identities = 23/77 (29%), Positives = 38/77 (49%), Gaps = 3/77 (3%)
Query: 193 EIEIIHVDLN-KNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEV 251
E ++ + LN K GLG +VAG E I V + +A Q G + D ++ V
Sbjct: 2625 EEDVCFIVLNRKEGSGLGFSVAGGT--DVEPKSITVHRVFSQGAASQEGTMNRGDFLLSV 2682
Query: 252 DGISLADKSNPQSVEIL 268
+G SLA ++ +++L
Sbjct: 2683 NGASLAGLAHGNVLKVL 2699
>AB014605-1|BAA31680.2| 1483|Homo sapiens KIAA0705 protein protein.
Length = 1483
Score = 70.9 bits (166), Expect = 1e-11
Identities = 148/628 (23%), Positives = 260/628 (41%), Gaps = 88/628 (14%)
Query: 15 LTNDGNGLGFNLVGGRSTG--VVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQ 72
L G GF ++GG + +K V+P G A +D ++++GD ++ + V + G T
Sbjct: 471 LKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHAD 530
Query: 73 VAAVLRQA--GPVVRLLVAR----PADPATALRAPQPGTALV--PTKILADPELLDRHLI 124
V + + G V L++ R P DP + P A++ P ++ + RH
Sbjct: 531 VVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVN----GRHNY 586
Query: 125 ETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQKIPDHPIVCDSVSPTIT 184
ET + SQ D I + + S+ + G P + D D+VS +
Sbjct: 587 ETYLEYISRTSQSVPD--ITDRPPHSLHSMPTDG-QLDGTYPPPVHD-----DNVSMASS 638
Query: 185 ITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKI 244
EL + I+ K G G T+A + +G VK I++ G +
Sbjct: 639 GATQAELMTLTIV-----KGAQGFGFTIA------DSPTGQRVKQILDIQGCP--GLCE- 684
Query: 245 NDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHLQLAIFNEERXXXX 304
D I+E++ ++ + S+ + V+IL++ I L + RG F + +R
Sbjct: 685 GDLIVEINQQNVQNLSHTEVVDILKDCPIGSETSLIIH-RGGFFSPWKTPKPIMDRWENQ 743
Query: 305 XXXXXXLSWFPVPSQLENSITEIEPEPESNTTIDSSVLEVGDLQEPTQEELDQRFDEILA 364
LS +P L P ++ DS+ E D ++P EL ++ I
Sbjct: 744 GSPQTSLSAPAIPQNLP-----FPPALHRSSFPDST--EAFDPRKPDPYELYEKSRAIYE 796
Query: 365 VDKEDIVKKWKEEIGSDKEILVAEIKKLE-GLGISLEGTVDVEGGQELRPHHYIRSVLPD 423
+ D +KE L ++++E G G + G E GQ + I +V+
Sbjct: 797 SRRPD----YKE--------LDVHLRRMESGFGFRILG--GDEPGQPI----LIGAVIAM 838
Query: 424 GPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP--DRVRLVCARNSIDSGPRPV 481
G G L+ GDEL+ V+ + G TH V++++ +V L R + G
Sbjct: 839 GSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCP 898
Query: 482 VNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVS 541
N S GS++ T +SD + T+S NH+ S + E +
Sbjct: 899 ENGRSP-----------GSVS--THHSSPRSDYATYTNS-----NHAAPSSNASPPEGFA 940
Query: 542 GLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIV---VRSLVPGGVAEKNGEIS 598
++ S D+V+ K ++G GF I+ + + T+ V + ++ G A++ ++
Sbjct: 941 SHSLQTS--DVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLK 998
Query: 599 PGDRVMSVNGVSIQNATLDQAVQALKGA 626
GDR+++VNG SI N V+ +K A
Sbjct: 999 VGDRILAVNGQSIINMPHADIVKLIKDA 1026
Score = 69.7 bits (163), Expect = 3e-11
Identities = 104/473 (21%), Positives = 196/473 (41%), Gaps = 46/473 (9%)
Query: 201 LNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKS 260
L K+ G G T+ G E +E + VKS+I A Q GK++ D I+ ++ + + +
Sbjct: 471 LKKSNMGFGFTIIGGD-EPDEF--LQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHT 527
Query: 261 NPQSVEILRNT--GISVHLVLERYLRGPKFEHLQLAIFNEERXXXXXXXXXXLSWFPVPS 318
+ V++ ++ G SV+LVL R P F+ E + P P
Sbjct: 528 HADVVKLFQSVPIGQSVNLVLCRGYPLP---------FDPEDPANSMVPPLAIMERPPPV 578
Query: 319 QLENSITEIEPEPESNTTIDSSVLEVGDLQEPTQEEL--DQRFDEILAVDKEDIVKKWKE 376
+ N E E + SV ++ D + + D + D D
Sbjct: 579 MV-NGRHNYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMAS 637
Query: 377 EIGSDKEILVAEIKK-LEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAG 435
+ E++ I K +G G ++ D GQ ++ I+ G G+ G
Sbjct: 638 SGATQAELMTLTIVKGAQGFGFTI---ADSPTGQRVKQILDIQ--------GCPGLCE-G 685
Query: 436 DELLEVNEYRLHGLTHSEVVNILKQLP--DRVRLVCARNSIDS---GPRPVVNLASDREG 490
D ++E+N+ + L+H+EVV+ILK P L+ R S P+P+++ + +G
Sbjct: 686 DLIVEINQQNVQNLSHTEVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMD-RWENQG 744
Query: 491 FEARKIISGSLNNLTTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKE 550
+ + ++ A +S S+ A + + + KE
Sbjct: 745 SPQTSLSAPAIPQNLPFPPALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRRPDYKE 804
Query: 551 DIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVS 610
V L + + G GF IL +P P I++ +++ G A+++G + PGD ++ V+G+
Sbjct: 805 LDVHLRRMESGFGFRILGGDEPGQP----ILIGAVIAMGSADRDGRLHPGDELVYVDGIP 860
Query: 611 IQNATLDQAVQALKGAPR-GTVKVGIARPL-----PPQDSSKSKGTINVNKAS 657
+ T + + A R G V + + R + P ++ +S G+++ + +S
Sbjct: 861 VAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSS 913
Score = 52.0 bits (119), Expect = 6e-06
Identities = 24/89 (26%), Positives = 53/89 (59%), Gaps = 3/89 (3%)
Query: 193 EIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVD 252
+ + VD+ K G G ++ G +E ++V + E A ++G++++ D+IIE++
Sbjct: 1170 DFDYFTVDMEKGAKGFGFSIRG---GREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEIN 1226
Query: 253 GISLADKSNPQSVEILRNTGISVHLVLER 281
G S D ++ +++E++++ G V L+L+R
Sbjct: 1227 GESTRDMTHARAIELIKSGGRRVRLLLKR 1255
Score = 47.6 bits (108), Expect = 1e-04
Identities = 20/69 (28%), Positives = 37/69 (53%)
Query: 405 VEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDR 464
+ GG+E + Y+ + DGP G + GD+++E+N +TH+ + ++K R
Sbjct: 1189 IRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKSGGRR 1248
Query: 465 VRLVCARNS 473
VRL+ R +
Sbjct: 1249 VRLLLKRGT 1257
Score = 42.7 bits (96), Expect = 0.004
Identities = 18/48 (37%), Positives = 34/48 (70%)
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHL 277
II+GS A++ K+K+ DRI+ V+G S+ + + V+++++ G+SV L
Sbjct: 985 IIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTL 1032
Score = 41.5 bits (93), Expect = 0.009
Identities = 25/94 (26%), Positives = 45/94 (47%), Gaps = 4/94 (4%)
Query: 13 VELTNDGNGLGFNLVGGRSTGVVIKYVL---PGGVADKDRRLQSGDHVLQVGSVNLRGFT 69
V++ G GF++ GGR + + YVL G A ++ R++ GD ++++ + R T
Sbjct: 1176 VDMEKGAKGFGFSIRGGREYKMDL-YVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMT 1234
Query: 70 SEQVAAVLRQAGPVVRLLVARPADPATALRAPQP 103
+ +++ G VRLL+ R P P
Sbjct: 1235 HARAIELIKSGGRRVRLLLKRGTGQVPEYDEPAP 1268
Score = 40.7 bits (91), Expect = 0.016
Identities = 23/70 (32%), Positives = 36/70 (51%), Gaps = 2/70 (2%)
Query: 13 VELTNDGNGLGFNLVGGRSTG--VVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTS 70
V L +G GF ++GG G ++I V+ G AD+D RL GD ++ V + + G T
Sbjct: 807 VHLRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTH 866
Query: 71 EQVAAVLRQA 80
V ++ A
Sbjct: 867 RYVIDLMHHA 876
Score = 39.1 bits (87), Expect = 0.049
Identities = 30/95 (31%), Positives = 47/95 (49%), Gaps = 5/95 (5%)
Query: 395 LGISLEGTV--DVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELL-EVNEYRLHGLTH 451
+G + EG + +++GG E Y+ V P G +ELL EVNE + GLT
Sbjct: 62 IGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKLVSEELLLEVNETPVAGLTI 121
Query: 452 SEVVNILKQLPDRVRLVCARNS--IDSGPRPVVNL 484
+V+ ++K D +RL C + +D R +NL
Sbjct: 122 RDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNL 156
Score = 35.5 bits (78), Expect = 0.60
Identities = 23/77 (29%), Positives = 41/77 (53%), Gaps = 6/77 (7%)
Query: 553 VMLVKADQGLGFSILDYQD-PVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSI 611
V + K +G GFSI ++ +D + V L G A +NG + GD+++ +NG S
Sbjct: 1176 VDMEKGAKGFGFSIRGGREYKMD-----LYVLRLAEDGPAIRNGRMRVGDQIIEINGEST 1230
Query: 612 QNATLDQAVQALKGAPR 628
++ T +A++ +K R
Sbjct: 1231 RDMTHARAIELIKSGGR 1247
>U12128-1|AAB60339.1| 2490|Homo sapiens protein tyrosine phosphatase
1E protein.
Length = 2490
Score = 69.7 bits (163), Expect = 3e-11
Identities = 41/102 (40%), Positives = 59/102 (57%), Gaps = 5/102 (4%)
Query: 195 EIIHVDLNKNVYGLGITVA-----GYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRII 249
+I V+L KN LGI+V G V GI+VK++I +AE G+I DR++
Sbjct: 1365 DIFEVELAKNDNSLGISVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVL 1424
Query: 250 EVDGISLADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHL 291
V+G+SL ++ Q+VE LRNTG VHL+LE+ EH+
Sbjct: 1425 AVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHV 1466
Score = 63.3 bits (147), Expect = 3e-09
Identities = 69/263 (26%), Positives = 112/263 (42%), Gaps = 37/263 (14%)
Query: 383 EILVAEIKKLEG-LGISLEGTVDVEGGQELRPHH---YIRSVLPDGPVGLQGVLNAGDEL 438
+I E+ K + LGIS+ D +GG H Y+++V+P G G ++ GD +
Sbjct: 1365 DIFEVELAKNDNSLGISVTVLFD-KGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRV 1423
Query: 439 LEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKIIS 498
L VN L G TH + V L+ V L+ ++ G P + + + +S
Sbjct: 1424 LAVNGVSLEGATHKQAVETLRNTGQVVHLL-----LEKGQSPT---SKEHVPVTPQCTLS 1475
Query: 499 GSLNNLTTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKA 558
K + T + S T N E S SGL S+ED ++
Sbjct: 1476 DQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNS----SGLGFSFSREDNLI---- 1527
Query: 559 DQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQ 618
P N +++ V+ L PG A ++G+I GD ++ VNG S++ + +
Sbjct: 1528 -------------PEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQE 1574
Query: 619 AVQALKG-APRGTVKVGIARPLP 640
+ AL+G AP V + + RP P
Sbjct: 1575 VISALRGTAPE--VFLLLCRPPP 1595
Score = 61.3 bits (142), Expect = 1e-08
Identities = 42/167 (25%), Positives = 74/167 (44%), Gaps = 5/167 (2%)
Query: 329 PEPESNTTIDSSVLEVGD--LQEPTQEELDQRFDEILAVDKEDIVKKWKEEIGSDKEILV 386
PE + + SS+ + G + T ++ + + + K+W ++EI +
Sbjct: 1034 PERRKHESDSSSIEDPGQAYVLGMTMHSSGNSSSQVPLKENDVLHKRWSIVSSPEREITL 1093
Query: 387 AEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRL 446
+KK G+ + + E L +I SV P GP L G L GD L+ VN L
Sbjct: 1094 VNLKKDAKYGLGFQ-IIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSL 1152
Query: 447 HGLTHSEVVNILKQLPDRVRLVCA--RNSIDSGPRPVVNLASDREGF 491
G++H + IL+ P+ V LV + + I P V+L ++ + +
Sbjct: 1153 EGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNY 1199
Score = 60.9 bits (141), Expect = 1e-08
Identities = 36/99 (36%), Positives = 50/99 (50%), Gaps = 10/99 (10%)
Query: 13 VELTNDGNGLGFNLV-----GGRST-----GVVIKYVLPGGVADKDRRLQSGDHVLQVGS 62
VEL + N LG ++ GG +T G+ +K V+P G A+ D R+ GD VL V
Sbjct: 1369 VELAKNDNSLGISVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNG 1428
Query: 63 VNLRGFTSEQVAAVLRQAGPVVRLLVARPADPATALRAP 101
V+L G T +Q LR G VV LL+ + P + P
Sbjct: 1429 VSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVP 1467
Score = 58.0 bits (134), Expect = 1e-07
Identities = 32/98 (32%), Positives = 53/98 (54%), Gaps = 6/98 (6%)
Query: 2 VLSTEWAQVEVVELTNDGN-GLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGD 55
++S+ ++ +V L D GLGF ++GG G + I V PGG AD D L+ GD
Sbjct: 1083 IVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGD 1142
Query: 56 HVLQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVARPAD 93
++ V SV+L G + +L+ A V L++++P +
Sbjct: 1143 RLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKE 1180
Score = 57.2 bits (132), Expect = 2e-07
Identities = 35/94 (37%), Positives = 51/94 (54%), Gaps = 1/94 (1%)
Query: 189 VELPEIEIIHVDLNKNV-YGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDR 247
V PE EI V+L K+ YGLG + G GIF+ S+ G A+ G +K DR
Sbjct: 1084 VSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDR 1143
Query: 248 IIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
+I V+ +SL S+ ++EIL+N V LV+ +
Sbjct: 1144 LISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQ 1177
Score = 51.6 bits (118), Expect = 9e-06
Identities = 29/81 (35%), Positives = 47/81 (58%), Gaps = 2/81 (2%)
Query: 558 ADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLD 617
A GLGF I+ + + I + S+ PGG A+ +G + PGDR++SVN VS++ +
Sbjct: 1100 AKYGLGFQIIG-GEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHH 1158
Query: 618 QAVQALKGAPRGTVKVGIARP 638
A++ L+ AP V I++P
Sbjct: 1159 AAIEILQNAPEDVTLV-ISQP 1178
Score = 50.0 bits (114), Expect = 3e-05
Identities = 43/144 (29%), Positives = 73/144 (50%), Gaps = 15/144 (10%)
Query: 328 EPEPESNTTIDSSVLEVGDLQEPTQEELDQRFDEILAVDKEDIVKKWKEEIGSDKEILVA 387
+P+ ES ++ + + EPT++E L D E+ ++ ++ E+ E+L+
Sbjct: 1744 QPQSESASSSSMDKYHIHHISEPTRQENWTP----LKNDLENHLEDFELEV----ELLIT 1795
Query: 388 EIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLH 447
IK +G SL TV +G Q + Y+ V+ D P G L GD L++VN+ +
Sbjct: 1796 LIKSEKG---SLGFTV-TKGNQRIGC--YVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVT 1848
Query: 448 GLTHSEVVNILKQLPDRVRLVCAR 471
+TH++ VN+L+ VRLV R
Sbjct: 1849 NMTHTDAVNLLRAASKTVRLVIGR 1872
Score = 48.0 bits (109), Expect = 1e-04
Identities = 32/92 (34%), Positives = 46/92 (50%), Gaps = 3/92 (3%)
Query: 193 EIEIIHVDLNKNVYGLGITVA---GYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRII 249
E V L KN GLG + + + E+ S + VK + G A +SGKI + D I+
Sbjct: 1501 EENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVIL 1560
Query: 250 EVDGISLADKSNPQSVEILRNTGISVHLVLER 281
+V+G SL S + + LR T V L+L R
Sbjct: 1561 KVNGASLKGLSQQEVISALRGTAPEVFLLLCR 1592
Score = 45.6 bits (103), Expect = 6e-04
Identities = 33/104 (31%), Positives = 55/104 (52%), Gaps = 12/104 (11%)
Query: 13 VELTNDGNGLGF------NLVGGRSTGVVI--KYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V+L + +GLGF NL+ + ++ K + PG A + ++ GD +L+V +
Sbjct: 1507 VKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGAS 1566
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALV 108
L+G + ++V + LR P V LL+ RP P L P+ TAL+
Sbjct: 1567 LKGLSQQEVISALRGTAPEVFLLLCRP--PPGVL--PEIDTALL 1606
Score = 41.1 bits (92), Expect = 0.012
Identities = 26/99 (26%), Positives = 50/99 (50%), Gaps = 5/99 (5%)
Query: 193 EIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVD 252
E+E++ + LG TV + + G +V +I+ A+ G++K DR+I+V+
Sbjct: 1789 EVELLITLIKSEKGSLGFTVT----KGNQRIGCYVHDVIQ-DPAKSDGRLKPGDRLIKVN 1843
Query: 253 GISLADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHL 291
+ + ++ +V +LR +V LV+ R L P+ L
Sbjct: 1844 DTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELPRIPML 1882
Score = 39.1 bits (87), Expect = 0.049
Identities = 27/91 (29%), Positives = 48/91 (52%), Gaps = 8/91 (8%)
Query: 550 EDIVMLVKADQG-LGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNG 608
E ++ L+K+++G LGF++ + V ++ A+ +G + PGDR++ VN
Sbjct: 1791 ELLITLIKSEKGSLGFTVTKGNQRIG-----CYVHDVIQDP-AKSDGRLKPGDRLIKVND 1844
Query: 609 VSIQNATLDQAVQALKGAPRGTVKVGIARPL 639
+ N T AV L+ A + TV++ I R L
Sbjct: 1845 TDVTNMTHTDAVNLLRAASK-TVRLVIGRVL 1874
Score = 35.9 bits (79), Expect = 0.45
Identities = 21/77 (27%), Positives = 37/77 (48%), Gaps = 2/77 (2%)
Query: 15 LTNDGNGLGFNLV-GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQV 73
+ ++ LGF + G + G + V+ A D RL+ GD +++V ++ T
Sbjct: 1797 IKSEKGSLGFTVTKGNQRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTNMTHTDA 1855
Query: 74 AAVLRQAGPVVRLLVAR 90
+LR A VRL++ R
Sbjct: 1856 VNLLRAASKTVRLVIGR 1872
Score = 35.5 bits (78), Expect = 0.60
Identities = 29/96 (30%), Positives = 43/96 (44%), Gaps = 4/96 (4%)
Query: 551 DIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVS 610
DI + ++ LGFS+ D + V+ + + P VA G + D + VNGVS
Sbjct: 1888 DITLTCNKEE-LGFSLCGGHDSLYQ---VVYISDINPRSVAAIEGNLQLLDVIHYVNGVS 1943
Query: 611 IQNATLDQAVQALKGAPRGTVKVGIARPLPPQDSSK 646
Q TL++ +AL + V LP SSK
Sbjct: 1944 TQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSK 1979
Score = 34.3 bits (75), Expect = 1.4
Identities = 29/99 (29%), Positives = 46/99 (46%), Gaps = 9/99 (9%)
Query: 13 VELTNDGNGLGFNLVGGRSTGVVIKYVL---PGGVADKDRRLQSGDHVLQVGSVNLRGFT 69
+ LT + LGF+L GG + + Y+ P VA + LQ D + V V+ +G T
Sbjct: 1889 ITLTCNKEELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMT 1948
Query: 70 SEQVAAVLRQAGPVVRLLVAR------PADPATALRAPQ 102
E+V L + P + L R P+ +A+ AP+
Sbjct: 1949 LEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPK 1987
>L34583-1|AAC41755.1| 610|Homo sapiens tyrosine phosphatase
protein.
Length = 610
Score = 69.7 bits (163), Expect = 3e-11
Identities = 41/102 (40%), Positives = 59/102 (57%), Gaps = 5/102 (4%)
Query: 195 EIIHVDLNKNVYGLGITVA-----GYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRII 249
+I V+L KN LGI+V G V GI+VK++I +AE G+I DR++
Sbjct: 87 DIFEVELAKNDNSLGISVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVL 146
Query: 250 EVDGISLADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHL 291
V+G+SL ++ Q+VE LRNTG VHL+LE+ EH+
Sbjct: 147 AVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHV 188
Score = 63.3 bits (147), Expect = 3e-09
Identities = 69/263 (26%), Positives = 112/263 (42%), Gaps = 37/263 (14%)
Query: 383 EILVAEIKKLEG-LGISLEGTVDVEGGQELRPHH---YIRSVLPDGPVGLQGVLNAGDEL 438
+I E+ K + LGIS+ D +GG H Y+++V+P G G ++ GD +
Sbjct: 87 DIFEVELAKNDNSLGISVTVLFD-KGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRV 145
Query: 439 LEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKIIS 498
L VN L G TH + V L+ V L+ ++ G P + + + +S
Sbjct: 146 LAVNGVSLEGATHKQAVETLRNTGQVVHLL-----LEKGQSPT---SKEHVPVTPQCTLS 197
Query: 499 GSLNNLTTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKA 558
K + T + S T N E S SGL S+ED ++
Sbjct: 198 DQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNS----SGLGFSFSREDNLI---- 249
Query: 559 DQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQ 618
P N +++ V+ L PG A ++G+I GD ++ VNG S++ + +
Sbjct: 250 -------------PEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQE 296
Query: 619 AVQALKG-APRGTVKVGIARPLP 640
+ AL+G AP V + + RP P
Sbjct: 297 VISALRGTAPE--VFLLLCRPPP 317
Score = 60.9 bits (141), Expect = 1e-08
Identities = 36/99 (36%), Positives = 50/99 (50%), Gaps = 10/99 (10%)
Query: 13 VELTNDGNGLGFNLV-----GGRST-----GVVIKYVLPGGVADKDRRLQSGDHVLQVGS 62
VEL + N LG ++ GG +T G+ +K V+P G A+ D R+ GD VL V
Sbjct: 91 VELAKNDNSLGISVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNG 150
Query: 63 VNLRGFTSEQVAAVLRQAGPVVRLLVARPADPATALRAP 101
V+L G T +Q LR G VV LL+ + P + P
Sbjct: 151 VSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVP 189
Score = 50.0 bits (114), Expect = 3e-05
Identities = 43/144 (29%), Positives = 73/144 (50%), Gaps = 15/144 (10%)
Query: 328 EPEPESNTTIDSSVLEVGDLQEPTQEELDQRFDEILAVDKEDIVKKWKEEIGSDKEILVA 387
+P+ ES ++ + + EPT++E L D E+ ++ ++ E+ E+L+
Sbjct: 466 QPQSESASSSSMDKYHIHHISEPTRQENWTP----LKNDLENHLEDFELEV----ELLIT 517
Query: 388 EIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLH 447
IK +G SL TV +G Q + Y+ V+ D P G L GD L++VN+ +
Sbjct: 518 LIKSEKG---SLGFTV-TKGNQRIGC--YVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVT 570
Query: 448 GLTHSEVVNILKQLPDRVRLVCAR 471
+TH++ VN+L+ VRLV R
Sbjct: 571 NMTHTDAVNLLRAASKTVRLVIGR 594
Score = 48.0 bits (109), Expect = 1e-04
Identities = 32/92 (34%), Positives = 46/92 (50%), Gaps = 3/92 (3%)
Query: 193 EIEIIHVDLNKNVYGLGITVA---GYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRII 249
E V L KN GLG + + + E+ S + VK + G A +SGKI + D I+
Sbjct: 223 EENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVIL 282
Query: 250 EVDGISLADKSNPQSVEILRNTGISVHLVLER 281
+V+G SL S + + LR T V L+L R
Sbjct: 283 KVNGASLKGLSQQEVISALRGTAPEVFLLLCR 314
Score = 45.6 bits (103), Expect = 6e-04
Identities = 33/104 (31%), Positives = 55/104 (52%), Gaps = 12/104 (11%)
Query: 13 VELTNDGNGLGF------NLVGGRSTGVVI--KYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V+L + +GLGF NL+ + ++ K + PG A + ++ GD +L+V +
Sbjct: 229 VKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGAS 288
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALV 108
L+G + ++V + LR P V LL+ RP P L P+ TAL+
Sbjct: 289 LKGLSQQEVISALRGTAPEVFLLLCRP--PPGVL--PEIDTALL 328
Score = 41.1 bits (92), Expect = 0.012
Identities = 26/99 (26%), Positives = 50/99 (50%), Gaps = 5/99 (5%)
Query: 193 EIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVD 252
E+E++ + LG TV + + G +V +I+ A+ G++K DR+I+V+
Sbjct: 511 EVELLITLIKSEKGSLGFTVT----KGNQRIGCYVHDVIQ-DPAKSDGRLKPGDRLIKVN 565
Query: 253 GISLADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHL 291
+ + ++ +V +LR +V LV+ R L P+ L
Sbjct: 566 DTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELPRIPML 604
Score = 39.1 bits (87), Expect = 0.049
Identities = 27/91 (29%), Positives = 48/91 (52%), Gaps = 8/91 (8%)
Query: 550 EDIVMLVKADQG-LGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNG 608
E ++ L+K+++G LGF++ + V ++ A+ +G + PGDR++ VN
Sbjct: 513 ELLITLIKSEKGSLGFTVTKGNQRIG-----CYVHDVIQDP-AKSDGRLKPGDRLIKVND 566
Query: 609 VSIQNATLDQAVQALKGAPRGTVKVGIARPL 639
+ N T AV L+ A + TV++ I R L
Sbjct: 567 TDVTNMTHTDAVNLLRAASK-TVRLVIGRVL 596
Score = 35.9 bits (79), Expect = 0.45
Identities = 21/77 (27%), Positives = 37/77 (48%), Gaps = 2/77 (2%)
Query: 15 LTNDGNGLGFNLV-GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQV 73
+ ++ LGF + G + G + V+ A D RL+ GD +++V ++ T
Sbjct: 519 IKSEKGSLGFTVTKGNQRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTNMTHTDA 577
Query: 74 AAVLRQAGPVVRLLVAR 90
+LR A VRL++ R
Sbjct: 578 VNLLRAASKTVRLVIGR 594
>AC105413-1|AAY40972.1| 1305|Homo sapiens unknown protein.
Length = 1305
Score = 69.7 bits (163), Expect = 3e-11
Identities = 41/102 (40%), Positives = 59/102 (57%), Gaps = 5/102 (4%)
Query: 195 EIIHVDLNKNVYGLGITVA-----GYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRII 249
+I V+L KN LGI+V G V GI+VK++I +AE G+I DR++
Sbjct: 180 DIFEVELAKNDNSLGISVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVL 239
Query: 250 EVDGISLADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHL 291
V+G+SL ++ Q+VE LRNTG VHL+LE+ EH+
Sbjct: 240 AVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHV 281
Score = 63.3 bits (147), Expect = 3e-09
Identities = 69/263 (26%), Positives = 112/263 (42%), Gaps = 37/263 (14%)
Query: 383 EILVAEIKKLEG-LGISLEGTVDVEGGQELRPHH---YIRSVLPDGPVGLQGVLNAGDEL 438
+I E+ K + LGIS+ D +GG H Y+++V+P G G ++ GD +
Sbjct: 180 DIFEVELAKNDNSLGISVTVLFD-KGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRV 238
Query: 439 LEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKIIS 498
L VN L G TH + V L+ V L+ ++ G P + + + +S
Sbjct: 239 LAVNGVSLEGATHKQAVETLRNTGQVVHLL-----LEKGQSPT---SKEHVPVTPQCTLS 290
Query: 499 GSLNNLTTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKA 558
K + T + S T N E S SGL S+ED ++
Sbjct: 291 DQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNS----SGLGFSFSREDNLI---- 342
Query: 559 DQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQ 618
P N +++ V+ L PG A ++G+I GD ++ VNG S++ + +
Sbjct: 343 -------------PEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQE 389
Query: 619 AVQALKG-APRGTVKVGIARPLP 640
+ AL+G AP V + + RP P
Sbjct: 390 VISALRGTAPE--VFLLLCRPPP 410
Score = 60.9 bits (141), Expect = 1e-08
Identities = 36/99 (36%), Positives = 50/99 (50%), Gaps = 10/99 (10%)
Query: 13 VELTNDGNGLGFNLV-----GGRST-----GVVIKYVLPGGVADKDRRLQSGDHVLQVGS 62
VEL + N LG ++ GG +T G+ +K V+P G A+ D R+ GD VL V
Sbjct: 184 VELAKNDNSLGISVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNG 243
Query: 63 VNLRGFTSEQVAAVLRQAGPVVRLLVARPADPATALRAP 101
V+L G T +Q LR G VV LL+ + P + P
Sbjct: 244 VSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVP 282
Score = 50.0 bits (114), Expect = 3e-05
Identities = 43/144 (29%), Positives = 73/144 (50%), Gaps = 15/144 (10%)
Query: 328 EPEPESNTTIDSSVLEVGDLQEPTQEELDQRFDEILAVDKEDIVKKWKEEIGSDKEILVA 387
+P+ ES ++ + + EPT++E L D E+ ++ ++ E+ E+L+
Sbjct: 559 QPQSESASSSSMDKYHIHHISEPTRQENWTP----LKNDLENHLEDFELEV----ELLIT 610
Query: 388 EIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLH 447
IK +G SL TV +G Q + Y+ V+ D P G L GD L++VN+ +
Sbjct: 611 LIKSEKG---SLGFTV-TKGNQRIGC--YVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVT 663
Query: 448 GLTHSEVVNILKQLPDRVRLVCAR 471
+TH++ VN+L+ VRLV R
Sbjct: 664 NMTHTDAVNLLRAASKTVRLVIGR 687
Score = 48.0 bits (109), Expect = 1e-04
Identities = 32/92 (34%), Positives = 46/92 (50%), Gaps = 3/92 (3%)
Query: 193 EIEIIHVDLNKNVYGLGITVA---GYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRII 249
E V L KN GLG + + + E+ S + VK + G A +SGKI + D I+
Sbjct: 316 EENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVIL 375
Query: 250 EVDGISLADKSNPQSVEILRNTGISVHLVLER 281
+V+G SL S + + LR T V L+L R
Sbjct: 376 KVNGASLKGLSQQEVISALRGTAPEVFLLLCR 407
Score = 45.6 bits (103), Expect = 6e-04
Identities = 33/104 (31%), Positives = 55/104 (52%), Gaps = 12/104 (11%)
Query: 13 VELTNDGNGLGF------NLVGGRSTGVVI--KYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V+L + +GLGF NL+ + ++ K + PG A + ++ GD +L+V +
Sbjct: 322 VKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGAS 381
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALV 108
L+G + ++V + LR P V LL+ RP P L P+ TAL+
Sbjct: 382 LKGLSQQEVISALRGTAPEVFLLLCRP--PPGVL--PEIDTALL 421
Score = 41.1 bits (92), Expect = 0.012
Identities = 26/99 (26%), Positives = 50/99 (50%), Gaps = 5/99 (5%)
Query: 193 EIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVD 252
E+E++ + LG TV + + G +V +I+ A+ G++K DR+I+V+
Sbjct: 604 EVELLITLIKSEKGSLGFTVT----KGNQRIGCYVHDVIQ-DPAKSDGRLKPGDRLIKVN 658
Query: 253 GISLADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHL 291
+ + ++ +V +LR +V LV+ R L P+ L
Sbjct: 659 DTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELPRIPML 697
Score = 39.1 bits (87), Expect = 0.049
Identities = 27/91 (29%), Positives = 48/91 (52%), Gaps = 8/91 (8%)
Query: 550 EDIVMLVKADQG-LGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNG 608
E ++ L+K+++G LGF++ + V ++ A+ +G + PGDR++ VN
Sbjct: 606 ELLITLIKSEKGSLGFTVTKGNQRIG-----CYVHDVIQDP-AKSDGRLKPGDRLIKVND 659
Query: 609 VSIQNATLDQAVQALKGAPRGTVKVGIARPL 639
+ N T AV L+ A + TV++ I R L
Sbjct: 660 TDVTNMTHTDAVNLLRAASK-TVRLVIGRVL 689
Score = 35.9 bits (79), Expect = 0.45
Identities = 21/77 (27%), Positives = 37/77 (48%), Gaps = 2/77 (2%)
Query: 15 LTNDGNGLGFNLV-GGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQV 73
+ ++ LGF + G + G + V+ A D RL+ GD +++V ++ T
Sbjct: 612 IKSEKGSLGFTVTKGNQRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTNMTHTDA 670
Query: 74 AAVLRQAGPVVRLLVAR 90
+LR A VRL++ R
Sbjct: 671 VNLLRAASKTVRLVIGR 687
Score = 35.5 bits (78), Expect = 0.60
Identities = 29/96 (30%), Positives = 43/96 (44%), Gaps = 4/96 (4%)
Query: 551 DIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVS 610
DI + ++ LGFS+ D + V+ + + P VA G + D + VNGVS
Sbjct: 703 DITLTCNKEE-LGFSLCGGHDSLYQ---VVYISDINPRSVAAIEGNLQLLDVIHYVNGVS 758
Query: 611 IQNATLDQAVQALKGAPRGTVKVGIARPLPPQDSSK 646
Q TL++ +AL + V LP SSK
Sbjct: 759 TQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSK 794
Score = 34.3 bits (75), Expect = 1.4
Identities = 29/99 (29%), Positives = 46/99 (46%), Gaps = 9/99 (9%)
Query: 13 VELTNDGNGLGFNLVGGRSTGVVIKYVL---PGGVADKDRRLQSGDHVLQVGSVNLRGFT 69
+ LT + LGF+L GG + + Y+ P VA + LQ D + V V+ +G T
Sbjct: 704 ITLTCNKEELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMT 763
Query: 70 SEQVAAVLRQAGPVVRLLVAR------PADPATALRAPQ 102
E+V L + P + L R P+ +A+ AP+
Sbjct: 764 LEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPK 802
>U32376-1|AAB04949.1| 870|Homo sapiens channel associated protein
of synapse protein.
Length = 870
Score = 68.9 bits (161), Expect = 5e-11
Identities = 36/85 (42%), Positives = 49/85 (57%), Gaps = 2/85 (2%)
Query: 13 VELTNDGNGLGFNLVGGRS-TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSE 71
V L GLGFN+VGG G+ + ++L GG AD LQ GD +L V ++LRG + E
Sbjct: 422 VVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHE 481
Query: 72 QVAAVLRQAGPVVRLLVA-RPADPA 95
Q AA L+ AG V ++ +P D A
Sbjct: 482 QAAAALKGAGQTVTIIAQYQPEDYA 506
Score = 63.7 bits (148), Expect = 2e-09
Identities = 42/130 (32%), Positives = 72/130 (55%), Gaps = 9/130 (6%)
Query: 524 LTNHSEQSKKSRSLECVSGLAM-WQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVV 582
+T+HS+ S +R A+ + + V+L K GLGF+I+ +D G I V
Sbjct: 392 MTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGED-----GEGIFV 446
Query: 583 RSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPLPPQ 642
++ GG A+ +GE+ GD+++SVNG+ ++ A+ +QA ALKGA + V I P+
Sbjct: 447 SFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQ---TVTIIAQYQPE 503
Query: 643 DSSKSKGTIN 652
D ++ + I+
Sbjct: 504 DYARFEAKIH 513
Score = 55.2 bits (127), Expect = 7e-07
Identities = 34/120 (28%), Positives = 63/120 (52%), Gaps = 4/120 (3%)
Query: 165 NPQKIPDHPIVCDSVS-PTITITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKE--E 221
+P K PI+ ++ + TI E+ E E + L + GLG ++AG +
Sbjct: 65 SPLKASPAPIIVNTDTLDTIPYVNGTEI-EYEFEEITLERGNSGLGFSIAGGTDNPHIGD 123
Query: 222 LSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
GIF+ II G +A + G++++ND I+ V+ + +++ S+ ++VE L+ G L + R
Sbjct: 124 DPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIARLYVRR 183
Score = 55.2 bits (127), Expect = 7e-07
Identities = 28/85 (32%), Positives = 54/85 (63%), Gaps = 4/85 (4%)
Query: 196 IIHVDLNKNVYGLGITVAGYVCEKEELSG---IFVKSIIEGSSAEQSGKIKINDRIIEVD 252
++ + L K GLG ++AG V + + G I+V II+G +A++ G++++ DR++ V+
Sbjct: 191 VVEIKLFKGPKGLGFSIAGGV-GNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVN 249
Query: 253 GISLADKSNPQSVEILRNTGISVHL 277
SL + ++ ++V IL+NT V+L
Sbjct: 250 NYSLEEVTHEEAVAILKNTSEVVYL 274
Score = 53.6 bits (123), Expect = 2e-06
Identities = 28/89 (31%), Positives = 47/89 (52%), Gaps = 7/89 (7%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRST-------GVVIKYVLPGGVADKDRRLQSGDHVLQVG 61
+ E + L +GLGF++ GG G+ I ++PGG A +D RL+ D +L+V
Sbjct: 95 EFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVN 154
Query: 62 SVNLRGFTSEQVAAVLRQAGPVVRLLVAR 90
V++ + + L++AG + RL V R
Sbjct: 155 EVDVSEVSHSKAVEALKEAGSIARLYVRR 183
Score = 53.6 bits (123), Expect = 2e-06
Identities = 29/86 (33%), Positives = 43/86 (50%), Gaps = 7/86 (8%)
Query: 13 VELTNDGNGLGFNLVGG-------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
++L GLGF++ GG + + ++ GG A KD RLQ GD +L V + +L
Sbjct: 194 IKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSL 253
Query: 66 RGFTSEQVAAVLRQAGPVVRLLVARP 91
T E+ A+L+ VV L V P
Sbjct: 254 EEVTHEEAVAILKNTSEVVYLKVGNP 279
Score = 52.8 bits (121), Expect = 4e-06
Identities = 34/100 (34%), Positives = 55/100 (55%), Gaps = 5/100 (5%)
Query: 181 PTITITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSG 240
P++T+ V L E E V L+K GLG + G E+ GIFV I+ G A+ SG
Sbjct: 405 PSMTLQRAVSL-EGEPRKVVLHKGSTGLGFNIVG----GEDGEGIFVSFILAGGPADLSG 459
Query: 241 KIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLE 280
+++ D+I+ V+GI L S+ Q+ L+ G +V ++ +
Sbjct: 460 ELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQ 499
Score = 52.4 bits (120), Expect = 5e-06
Identities = 30/84 (35%), Positives = 45/84 (53%), Gaps = 2/84 (2%)
Query: 553 VMLVKADQGLGFSILD-YQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSI 611
+ L K +GLGFSI + P I V ++ GG A+K+G + GDR++ VN S+
Sbjct: 194 IKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSL 253
Query: 612 QNATLDQAVQALKGAPRGT-VKVG 634
+ T ++AV LK +KVG
Sbjct: 254 EEVTHEEAVAILKNTSEVVYLKVG 277
Score = 47.2 bits (107), Expect = 2e-04
Identities = 29/88 (32%), Positives = 47/88 (53%), Gaps = 2/88 (2%)
Query: 540 VSGLAMWQSKEDIVMLVKADQGLGFSILDYQD-PVDPNGTVIVVRSLVPGGVAEKNGEIS 598
V+G + E+I L + + GLGFSI D P + I + ++PGG A ++G +
Sbjct: 87 VNGTEIEYEFEEIT-LERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLR 145
Query: 599 PGDRVMSVNGVSIQNATLDQAVQALKGA 626
D ++ VN V + + +AV+ALK A
Sbjct: 146 VNDCILRVNEVDVSEVSHSKAVEALKEA 173
Score = 46.4 bits (105), Expect = 3e-04
Identities = 33/87 (37%), Positives = 42/87 (48%), Gaps = 8/87 (9%)
Query: 386 VAEIKKLEG---LGISLEGTVDVEGGQELRPHH--YIRSVLPDGPVGLQGVLNAGDELLE 440
V EIK +G LG S+ G V G Q + + Y+ ++ G G L GD LL
Sbjct: 191 VVEIKLFKGPKGLGFSIAGGV---GNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLM 247
Query: 441 VNEYRLHGLTHSEVVNILKQLPDRVRL 467
VN Y L +TH E V ILK + V L
Sbjct: 248 VNNYSLEEVTHEEAVAILKNTSEVVYL 274
Score = 40.7 bits (91), Expect = 0.016
Identities = 24/75 (32%), Positives = 35/75 (46%), Gaps = 7/75 (9%)
Query: 394 GLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSE 453
GLG ++ G D EG ++ +L GP L G L GD++L VN L G +H +
Sbjct: 430 GLGFNIVGGEDGEG-------IFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQ 482
Query: 454 VVNILKQLPDRVRLV 468
LK V ++
Sbjct: 483 AAAALKGAGQTVTII 497
Score = 39.9 bits (89), Expect = 0.028
Identities = 26/79 (32%), Positives = 37/79 (46%), Gaps = 3/79 (3%)
Query: 394 GLGISLEGTVDVEG-GQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHS 452
GLG S+ G D G + P +I ++P G G L D +L VNE + ++HS
Sbjct: 107 GLGFSIAGGTDNPHIGDD--PGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHS 164
Query: 453 EVVNILKQLPDRVRLVCAR 471
+ V LK+ RL R
Sbjct: 165 KAVEALKEAGSIARLYVRR 183
>AB209252-1|BAD92489.1| 555|Homo sapiens chapsyn-110 variant
protein.
Length = 555
Score = 68.9 bits (161), Expect = 5e-11
Identities = 36/85 (42%), Positives = 49/85 (57%), Gaps = 2/85 (2%)
Query: 13 VELTNDGNGLGFNLVGGRS-TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSE 71
V L GLGFN+VGG G+ + ++L GG AD LQ GD +L V ++LRG + E
Sbjct: 435 VVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHE 494
Query: 72 QVAAVLRQAGPVVRLLVA-RPADPA 95
Q AA L+ AG V ++ +P D A
Sbjct: 495 QAAAALKGAGQTVTIIAQYQPEDYA 519
Score = 63.7 bits (148), Expect = 2e-09
Identities = 42/130 (32%), Positives = 72/130 (55%), Gaps = 9/130 (6%)
Query: 524 LTNHSEQSKKSRSLECVSGLAM-WQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVV 582
+T+HS+ S +R A+ + + V+L K GLGF+I+ +D G I V
Sbjct: 405 MTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGED-----GEGIFV 459
Query: 583 RSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPLPPQ 642
++ GG A+ +GE+ GD+++SVNG+ ++ A+ +QA ALKGA + V I P+
Sbjct: 460 SFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQ---TVTIIAQYQPE 516
Query: 643 DSSKSKGTIN 652
D ++ + I+
Sbjct: 517 DYARFEAKIH 526
Score = 56.8 bits (131), Expect = 2e-07
Identities = 35/120 (29%), Positives = 64/120 (53%), Gaps = 4/120 (3%)
Query: 165 NPQKIPDHPIVCDSVS-PTITITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKE--E 221
+P K PI+ ++ + TI E+ E E + L + GLG ++AG +
Sbjct: 78 SPLKASPAPIIVNTDTLDTIPYVNGTEI-EYEFEEITLERGNSGLGFSIAGGTDNPHIGD 136
Query: 222 LSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
GIF+ II G +A + G++++ND I+ V+ + +++ S+ ++VE L+ G V L + R
Sbjct: 137 DPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRR 196
Score = 55.2 bits (127), Expect = 7e-07
Identities = 29/89 (32%), Positives = 48/89 (53%), Gaps = 7/89 (7%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRST-------GVVIKYVLPGGVADKDRRLQSGDHVLQVG 61
+ E + L +GLGF++ GG G+ I ++PGG A +D RL+ D +L+V
Sbjct: 108 EFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVN 167
Query: 62 SVNLRGFTSEQVAAVLRQAGPVVRLLVAR 90
V++ + + L++AG +VRL V R
Sbjct: 168 EVDVSEVSHSKAVEALKEAGSIVRLYVRR 196
Score = 55.2 bits (127), Expect = 7e-07
Identities = 28/85 (32%), Positives = 54/85 (63%), Gaps = 4/85 (4%)
Query: 196 IIHVDLNKNVYGLGITVAGYVCEKEELSG---IFVKSIIEGSSAEQSGKIKINDRIIEVD 252
++ + L K GLG ++AG V + + G I+V II+G +A++ G++++ DR++ V+
Sbjct: 204 VVEIKLFKGPKGLGFSIAGGV-GNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVN 262
Query: 253 GISLADKSNPQSVEILRNTGISVHL 277
SL + ++ ++V IL+NT V+L
Sbjct: 263 NYSLEEVTHEEAVAILKNTSEVVYL 287
Score = 54.4 bits (125), Expect = 1e-06
Identities = 29/86 (33%), Positives = 44/86 (51%), Gaps = 7/86 (8%)
Query: 13 VELTNDGNGLGFNLVGG-------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
++L GLGF++ GG + + ++ GG A KD RLQ GD +L V + +L
Sbjct: 207 IKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSL 266
Query: 66 RGFTSEQVAAVLRQAGPVVRLLVARP 91
T E+ A+L+ VV L V +P
Sbjct: 267 EEVTHEEAVAILKNTSEVVYLKVGKP 292
Score = 52.8 bits (121), Expect = 4e-06
Identities = 34/100 (34%), Positives = 55/100 (55%), Gaps = 5/100 (5%)
Query: 181 PTITITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSG 240
P++T+ V L E E V L+K GLG + G E+ GIFV I+ G A+ SG
Sbjct: 418 PSMTLQRAVSL-EGEPRKVVLHKGSTGLGFNIVG----GEDGEGIFVSFILAGGPADLSG 472
Query: 241 KIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLE 280
+++ D+I+ V+GI L S+ Q+ L+ G +V ++ +
Sbjct: 473 ELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQ 512
Score = 52.4 bits (120), Expect = 5e-06
Identities = 30/84 (35%), Positives = 45/84 (53%), Gaps = 2/84 (2%)
Query: 553 VMLVKADQGLGFSILD-YQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSI 611
+ L K +GLGFSI + P I V ++ GG A+K+G + GDR++ VN S+
Sbjct: 207 IKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSL 266
Query: 612 QNATLDQAVQALKGAPRGT-VKVG 634
+ T ++AV LK +KVG
Sbjct: 267 EEVTHEEAVAILKNTSEVVYLKVG 290
Score = 47.2 bits (107), Expect = 2e-04
Identities = 29/88 (32%), Positives = 47/88 (53%), Gaps = 2/88 (2%)
Query: 540 VSGLAMWQSKEDIVMLVKADQGLGFSILDYQD-PVDPNGTVIVVRSLVPGGVAEKNGEIS 598
V+G + E+I L + + GLGFSI D P + I + ++PGG A ++G +
Sbjct: 100 VNGTEIEYEFEEIT-LERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLR 158
Query: 599 PGDRVMSVNGVSIQNATLDQAVQALKGA 626
D ++ VN V + + +AV+ALK A
Sbjct: 159 VNDCILRVNEVDVSEVSHSKAVEALKEA 186
Score = 46.4 bits (105), Expect = 3e-04
Identities = 33/87 (37%), Positives = 42/87 (48%), Gaps = 8/87 (9%)
Query: 386 VAEIKKLEG---LGISLEGTVDVEGGQELRPHH--YIRSVLPDGPVGLQGVLNAGDELLE 440
V EIK +G LG S+ G V G Q + + Y+ ++ G G L GD LL
Sbjct: 204 VVEIKLFKGPKGLGFSIAGGV---GNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLM 260
Query: 441 VNEYRLHGLTHSEVVNILKQLPDRVRL 467
VN Y L +TH E V ILK + V L
Sbjct: 261 VNNYSLEEVTHEEAVAILKNTSEVVYL 287
Score = 41.5 bits (93), Expect = 0.009
Identities = 27/79 (34%), Positives = 38/79 (48%), Gaps = 3/79 (3%)
Query: 394 GLGISLEGTVDVEG-GQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHS 452
GLG S+ G D G + P +I ++P G G L D +L VNE + ++HS
Sbjct: 120 GLGFSIAGGTDNPHIGDD--PGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHS 177
Query: 453 EVVNILKQLPDRVRLVCAR 471
+ V LK+ VRL R
Sbjct: 178 KAVEALKEAGSIVRLYVRR 196
Score = 40.7 bits (91), Expect = 0.016
Identities = 24/75 (32%), Positives = 35/75 (46%), Gaps = 7/75 (9%)
Query: 394 GLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSE 453
GLG ++ G D EG ++ +L GP L G L GD++L VN L G +H +
Sbjct: 443 GLGFNIVGGEDGEG-------IFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQ 495
Query: 454 VVNILKQLPDRVRLV 468
LK V ++
Sbjct: 496 AAAALKGAGQTVTII 510
>AK127150-1|BAC86854.1| 552|Homo sapiens protein ( Homo sapiens
cDNA FLJ45207 fis, clone BRCAN2010665, highly similar
to Channel associated protein of synapse-110. ).
Length = 552
Score = 68.1 bits (159), Expect = 9e-11
Identities = 33/76 (43%), Positives = 45/76 (59%), Gaps = 1/76 (1%)
Query: 13 VELTNDGNGLGFNLVGGRS-TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSE 71
V L GLGFN+VGG G+ + ++L GG AD LQ GD +L V ++LRG + E
Sbjct: 461 VVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHE 520
Query: 72 QVAAVLRQAGPVVRLL 87
Q AA L+ AG V ++
Sbjct: 521 QAAAALKGAGQTVTII 536
Score = 62.5 bits (145), Expect = 5e-09
Identities = 37/104 (35%), Positives = 61/104 (58%), Gaps = 6/104 (5%)
Query: 524 LTNHSEQSKKSRSLECVSGLAM-WQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVV 582
+T+HS+ S +R A+ + + V+L K GLGF+I+ +D G I V
Sbjct: 431 MTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGED-----GEGIFV 485
Query: 583 RSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGA 626
++ GG A+ +GE+ GD+++SVNG+ ++ A+ +QA ALKGA
Sbjct: 486 SFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGA 529
Score = 55.6 bits (128), Expect = 5e-07
Identities = 34/120 (28%), Positives = 64/120 (53%), Gaps = 4/120 (3%)
Query: 165 NPQKIPDHPIVCDSVS-PTITITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKE--E 221
+P + PI+ ++ + TI E+ E E + L + GLG ++AG +
Sbjct: 104 SPAQASPAPIIVNTDTLDTIPYVNGTEI-EYEFEEITLERGNSGLGFSIAGGTDNPHIGD 162
Query: 222 LSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
GIF+ II G +A + G++++ND I+ V+ + +++ S+ ++VE L+ G V L + R
Sbjct: 163 DPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRR 222
Score = 55.2 bits (127), Expect = 7e-07
Identities = 29/89 (32%), Positives = 48/89 (53%), Gaps = 7/89 (7%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRST-------GVVIKYVLPGGVADKDRRLQSGDHVLQVG 61
+ E + L +GLGF++ GG G+ I ++PGG A +D RL+ D +L+V
Sbjct: 134 EFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVN 193
Query: 62 SVNLRGFTSEQVAAVLRQAGPVVRLLVAR 90
V++ + + L++AG +VRL V R
Sbjct: 194 EVDVSEVSHSKAVEALKEAGSIVRLYVRR 222
Score = 55.2 bits (127), Expect = 7e-07
Identities = 28/85 (32%), Positives = 54/85 (63%), Gaps = 4/85 (4%)
Query: 196 IIHVDLNKNVYGLGITVAGYVCEKEELSG---IFVKSIIEGSSAEQSGKIKINDRIIEVD 252
++ + L K GLG ++AG V + + G I+V II+G +A++ G++++ DR++ V+
Sbjct: 230 VVEIKLFKGPKGLGFSIAGGV-GNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVN 288
Query: 253 GISLADKSNPQSVEILRNTGISVHL 277
SL + ++ ++V IL+NT V+L
Sbjct: 289 NYSLEEVTHEEAVAILKNTSEVVYL 313
Score = 54.4 bits (125), Expect = 1e-06
Identities = 29/86 (33%), Positives = 44/86 (51%), Gaps = 7/86 (8%)
Query: 13 VELTNDGNGLGFNLVGG-------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
++L GLGF++ GG + + ++ GG A KD RLQ GD +L V + +L
Sbjct: 233 IKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSL 292
Query: 66 RGFTSEQVAAVLRQAGPVVRLLVARP 91
T E+ A+L+ VV L V +P
Sbjct: 293 EEVTHEEAVAILKNTSEVVYLKVGKP 318
Score = 53.2 bits (122), Expect = 3e-06
Identities = 38/116 (32%), Positives = 61/116 (52%), Gaps = 7/116 (6%)
Query: 181 PTITITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSG 240
P++T+ V L E E V L+K GLG + G E+ GIFV I+ G A+ SG
Sbjct: 444 PSMTLQRAVSL-EGEPRKVVLHKGSTGLGFNIVG----GEDGEGIFVSFILAGGPADLSG 498
Query: 241 KIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHLQLAIF 296
+++ D+I+ V+GI L S+ Q+ L+ G +V ++ + G L+L +F
Sbjct: 499 ELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEGQ--SELKLIMF 552
Score = 52.4 bits (120), Expect = 5e-06
Identities = 30/84 (35%), Positives = 45/84 (53%), Gaps = 2/84 (2%)
Query: 553 VMLVKADQGLGFSILD-YQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSI 611
+ L K +GLGFSI + P I V ++ GG A+K+G + GDR++ VN S+
Sbjct: 233 IKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSL 292
Query: 612 QNATLDQAVQALKGAPRGT-VKVG 634
+ T ++AV LK +KVG
Sbjct: 293 EEVTHEEAVAILKNTSEVVYLKVG 316
Score = 47.2 bits (107), Expect = 2e-04
Identities = 29/88 (32%), Positives = 47/88 (53%), Gaps = 2/88 (2%)
Query: 540 VSGLAMWQSKEDIVMLVKADQGLGFSILDYQD-PVDPNGTVIVVRSLVPGGVAEKNGEIS 598
V+G + E+I L + + GLGFSI D P + I + ++PGG A ++G +
Sbjct: 126 VNGTEIEYEFEEIT-LERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLR 184
Query: 599 PGDRVMSVNGVSIQNATLDQAVQALKGA 626
D ++ VN V + + +AV+ALK A
Sbjct: 185 VNDCILRVNEVDVSEVSHSKAVEALKEA 212
Score = 46.4 bits (105), Expect = 3e-04
Identities = 33/87 (37%), Positives = 42/87 (48%), Gaps = 8/87 (9%)
Query: 386 VAEIKKLEG---LGISLEGTVDVEGGQELRPHH--YIRSVLPDGPVGLQGVLNAGDELLE 440
V EIK +G LG S+ G V G Q + + Y+ ++ G G L GD LL
Sbjct: 230 VVEIKLFKGPKGLGFSIAGGV---GNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLM 286
Query: 441 VNEYRLHGLTHSEVVNILKQLPDRVRL 467
VN Y L +TH E V ILK + V L
Sbjct: 287 VNNYSLEEVTHEEAVAILKNTSEVVYL 313
Score = 41.5 bits (93), Expect = 0.009
Identities = 27/79 (34%), Positives = 38/79 (48%), Gaps = 3/79 (3%)
Query: 394 GLGISLEGTVDVEG-GQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHS 452
GLG S+ G D G + P +I ++P G G L D +L VNE + ++HS
Sbjct: 146 GLGFSIAGGTDNPHIGDD--PGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHS 203
Query: 453 EVVNILKQLPDRVRLVCAR 471
+ V LK+ VRL R
Sbjct: 204 KAVEALKEAGSIVRLYVRR 222
Score = 40.7 bits (91), Expect = 0.016
Identities = 24/75 (32%), Positives = 35/75 (46%), Gaps = 7/75 (9%)
Query: 394 GLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSE 453
GLG ++ G D EG ++ +L GP L G L GD++L VN L G +H +
Sbjct: 469 GLGFNIVGGEDGEG-------IFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQ 521
Query: 454 VVNILKQLPDRVRLV 468
LK V ++
Sbjct: 522 AAAALKGAGQTVTII 536
>AL139398-4|CAI41023.1| 512|Homo sapiens discs, large homolog 3
(neuroendocrine-dlg, Drosophila) protein.
Length = 512
Score = 67.7 bits (158), Expect = 1e-10
Identities = 35/81 (43%), Positives = 47/81 (58%), Gaps = 2/81 (2%)
Query: 15 LTNDGNGLGFNLVGGRS-TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQV 73
L GLGFN+VGG G+ + ++L GG AD L+ GD +L V VNLR T EQ
Sbjct: 52 LHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQA 111
Query: 74 AAVLRQAGPVVRLLVA-RPAD 93
AA L++AG V ++ RP +
Sbjct: 112 AAALKRAGQSVTIVAQYRPEE 132
Score = 64.1 bits (149), Expect = 1e-09
Identities = 36/86 (41%), Positives = 53/86 (61%), Gaps = 5/86 (5%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
++L K GLGF+I+ +D G I V ++ GG A+ +GE+ GDR++SVNGV+++
Sbjct: 50 IILHKGSTGLGFNIVGGED-----GEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLR 104
Query: 613 NATLDQAVQALKGAPRGTVKVGIARP 638
NAT +QA ALK A + V RP
Sbjct: 105 NATHEQAAAALKRAGQSVTIVAQYRP 130
Score = 52.8 bits (121), Expect = 4e-06
Identities = 28/80 (35%), Positives = 47/80 (58%), Gaps = 4/80 (5%)
Query: 201 LNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKS 260
L+K GLG + G E+ GIFV I+ G A+ SG+++ DRI+ V+G++L + +
Sbjct: 52 LHKGSTGLGFNIVG----GEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNAT 107
Query: 261 NPQSVEILRNTGISVHLVLE 280
+ Q+ L+ G SV +V +
Sbjct: 108 HEQAAAALKRAGQSVTIVAQ 127
Score = 41.5 bits (93), Expect = 0.009
Identities = 25/75 (33%), Positives = 34/75 (45%), Gaps = 7/75 (9%)
Query: 394 GLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSE 453
GLG ++ G D EG ++ +L GP L G L GD +L VN L TH +
Sbjct: 58 GLGFNIVGGEDGEG-------IFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQ 110
Query: 454 VVNILKQLPDRVRLV 468
LK+ V +V
Sbjct: 111 AAAALKRAGQSVTIV 125
>AB033058-1|BAA86546.1| 520|Homo sapiens KIAA1232 protein protein.
Length = 520
Score = 67.7 bits (158), Expect = 1e-10
Identities = 35/81 (43%), Positives = 47/81 (58%), Gaps = 2/81 (2%)
Query: 15 LTNDGNGLGFNLVGGRS-TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQV 73
L GLGFN+VGG G+ + ++L GG AD L+ GD +L V VNLR T EQ
Sbjct: 60 LHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQA 119
Query: 74 AAVLRQAGPVVRLLVA-RPAD 93
AA L++AG V ++ RP +
Sbjct: 120 AAALKRAGQSVTIVAQYRPEE 140
Score = 64.1 bits (149), Expect = 1e-09
Identities = 36/86 (41%), Positives = 53/86 (61%), Gaps = 5/86 (5%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
++L K GLGF+I+ +D G I V ++ GG A+ +GE+ GDR++SVNGV+++
Sbjct: 58 IILHKGSTGLGFNIVGGED-----GEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLR 112
Query: 613 NATLDQAVQALKGAPRGTVKVGIARP 638
NAT +QA ALK A + V RP
Sbjct: 113 NATHEQAAAALKRAGQSVTIVAQYRP 138
Score = 52.8 bits (121), Expect = 4e-06
Identities = 28/80 (35%), Positives = 47/80 (58%), Gaps = 4/80 (5%)
Query: 201 LNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKS 260
L+K GLG + G E+ GIFV I+ G A+ SG+++ DRI+ V+G++L + +
Sbjct: 60 LHKGSTGLGFNIVG----GEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNAT 115
Query: 261 NPQSVEILRNTGISVHLVLE 280
+ Q+ L+ G SV +V +
Sbjct: 116 HEQAAAALKRAGQSVTIVAQ 135
Score = 41.5 bits (93), Expect = 0.009
Identities = 25/75 (33%), Positives = 34/75 (45%), Gaps = 7/75 (9%)
Query: 394 GLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSE 453
GLG ++ G D EG ++ +L GP L G L GD +L VN L TH +
Sbjct: 66 GLGFNIVGGEDGEG-------IFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQ 118
Query: 454 VVNILKQLPDRVRLV 468
LK+ V +V
Sbjct: 119 AAAALKRAGQSVTIV 133
>BC040533-1|AAH40533.1| 549|Homo sapiens DLG4 protein protein.
Length = 549
Score = 67.3 bits (157), Expect = 2e-10
Identities = 61/237 (25%), Positives = 106/237 (44%), Gaps = 21/237 (8%)
Query: 416 YIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSID 475
Y+ ++ G G L GD++L VN L + H + V LK D V L A+
Sbjct: 15 YVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAK---- 70
Query: 476 SGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTSSTATLTNHSEQSKKSR 535
P SD + I + +L + S + + T T+ S ++
Sbjct: 71 ----PSNAYLSD--SYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAK 124
Query: 536 SLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNG 595
L + + +++ + GLGF+I+ +D G I + ++ GG A+ +G
Sbjct: 125 DLLGEEDIPREPRR---IVIHRGSTGLGFNIVGGED-----GEGIFISFILAGGPADLSG 176
Query: 596 EISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPLPPQDSSKSKGTIN 652
E+ GD+++SVNGV ++NA+ +QA ALK A + V I P++ S+ + I+
Sbjct: 177 ELRKGDQILSVNGVDLRNASHEQAAIALKNAGQ---TVTIIAQYKPEEYSRFEAKIH 230
Score = 62.9 bits (146), Expect = 3e-09
Identities = 30/68 (44%), Positives = 41/68 (60%), Gaps = 1/68 (1%)
Query: 21 GLGFNLVGGRS-TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAVLRQ 79
GLGFN+VGG G+ I ++L GG AD L+ GD +L V V+LR + EQ A L+
Sbjct: 147 GLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKN 206
Query: 80 AGPVVRLL 87
AG V ++
Sbjct: 207 AGQTVTII 214
Score = 51.2 bits (117), Expect = 1e-05
Identities = 32/111 (28%), Positives = 57/111 (51%), Gaps = 1/111 (0%)
Query: 171 DHPIVCDSVSPTITITVPVELPEIEIIHVDLNKNVYGLGITVAGY-VCEKEELSGIFVKS 229
D+P SP V +L E I + + V G T G+ + E+ GIF+
Sbjct: 106 DYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISF 165
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLE 280
I+ G A+ SG+++ D+I+ V+G+ L + S+ Q+ L+N G +V ++ +
Sbjct: 166 ILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQ 216
Score = 49.6 bits (113), Expect = 3e-05
Identities = 29/73 (39%), Positives = 40/73 (54%), Gaps = 1/73 (1%)
Query: 21 GLGFNLVGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAVLRQA 80
G+G + G ++ V K ++ GG A KD RLQ GD +L V SV L E A L+
Sbjct: 2 GVGNQHIPGDNSIYVTK-IIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNT 60
Query: 81 GPVVRLLVARPAD 93
VV L VA+P++
Sbjct: 61 YDVVYLKVAKPSN 73
Score = 44.8 bits (101), Expect = 0.001
Identities = 21/64 (32%), Positives = 36/64 (56%), Gaps = 1/64 (1%)
Query: 575 PNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVG 634
P I V ++ GG A K+G + GD++++VN V +++ + AV ALK V +
Sbjct: 9 PGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNT-YDVVYLK 67
Query: 635 IARP 638
+A+P
Sbjct: 68 VAKP 71
Score = 44.4 bits (100), Expect = 0.001
Identities = 20/55 (36%), Positives = 35/55 (63%)
Query: 223 SGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHL 277
+ I+V IIEG +A + G+++I D+I+ V+ + L D + +V L+NT V+L
Sbjct: 12 NSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYL 66
Score = 39.1 bits (87), Expect = 0.049
Identities = 24/75 (32%), Positives = 34/75 (45%), Gaps = 7/75 (9%)
Query: 394 GLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSE 453
GLG ++ G D EG +I +L GP L G L GD++L VN L +H +
Sbjct: 147 GLGFNIVGGEDGEG-------IFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQ 199
Query: 454 VVNILKQLPDRVRLV 468
LK V ++
Sbjct: 200 AAIALKNAGQTVTII 214
>BC027618-1|AAH27618.1| 207|Homo sapiens lin-7 homolog B (C.
elegans) protein.
Length = 207
Score = 66.1 bits (154), Expect = 4e-10
Identities = 33/82 (40%), Positives = 57/82 (69%), Gaps = 5/82 (6%)
Query: 552 IVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSI 611
+V L K D+GLGF+I+ ++ P I + ++PGGVA+++G + GD+++SVNGVS+
Sbjct: 93 VVELPKTDEGLGFNIMGGKEQNSP----IYISRVIPGGVADRHGGLKRGDQLLSVNGVSV 148
Query: 612 QNATLDQAVQALKGAPRGTVKV 633
+ ++AV+ LK A +G+VK+
Sbjct: 149 EGEQHEKAVELLKAA-QGSVKL 169
Score = 62.1 bits (144), Expect = 6e-09
Identities = 33/83 (39%), Positives = 50/83 (60%), Gaps = 2/83 (2%)
Query: 8 AQVEVVELTNDGNGLGFNLVGGR--STGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
A VVEL GLGFN++GG+ ++ + I V+PGGVAD+ L+ GD +L V V++
Sbjct: 89 AHPRVVELPKTDEGLGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSV 148
Query: 66 RGFTSEQVAAVLRQAGPVVRLLV 88
G E+ +L+ A V+L+V
Sbjct: 149 EGEQHEKAVELLKAAQGSVKLVV 171
Score = 50.8 bits (116), Expect = 1e-05
Identities = 29/84 (34%), Positives = 51/84 (60%), Gaps = 4/84 (4%)
Query: 199 VDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLAD 258
V+L K GLG + G KE+ S I++ +I G A++ G +K D+++ V+G+S+
Sbjct: 94 VELPKTDEGLGFNIMG---GKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEG 150
Query: 259 KSNPQSVEILRNTGISVHLVLERY 282
+ + ++VE+L+ SV LV+ RY
Sbjct: 151 EQHEKAVELLKAAQGSVKLVV-RY 173
Score = 47.2 bits (107), Expect = 2e-04
Identities = 31/84 (36%), Positives = 41/84 (48%), Gaps = 7/84 (8%)
Query: 386 VAEIKKL-EGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEY 444
V E+ K EGLG + + GG+E YI V+P G G L GD+LL VN
Sbjct: 93 VVELPKTDEGLGFN------IMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGV 146
Query: 445 RLHGLTHSEVVNILKQLPDRVRLV 468
+ G H + V +LK V+LV
Sbjct: 147 SVEGEQHEKAVELLKAAQGSVKLV 170
>AY358744-1|AAQ89104.1| 207|Homo sapiens LIN-7B protein.
Length = 207
Score = 66.1 bits (154), Expect = 4e-10
Identities = 33/82 (40%), Positives = 57/82 (69%), Gaps = 5/82 (6%)
Query: 552 IVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSI 611
+V L K D+GLGF+I+ ++ P I + ++PGGVA+++G + GD+++SVNGVS+
Sbjct: 93 VVELPKTDEGLGFNIMGGKEQNSP----IYISRVIPGGVADRHGGLKRGDQLLSVNGVSV 148
Query: 612 QNATLDQAVQALKGAPRGTVKV 633
+ ++AV+ LK A +G+VK+
Sbjct: 149 EGEQHEKAVELLKAA-QGSVKL 169
Score = 62.1 bits (144), Expect = 6e-09
Identities = 33/83 (39%), Positives = 50/83 (60%), Gaps = 2/83 (2%)
Query: 8 AQVEVVELTNDGNGLGFNLVGGR--STGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
A VVEL GLGFN++GG+ ++ + I V+PGGVAD+ L+ GD +L V V++
Sbjct: 89 AHPRVVELPKTDEGLGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSV 148
Query: 66 RGFTSEQVAAVLRQAGPVVRLLV 88
G E+ +L+ A V+L+V
Sbjct: 149 EGEQHEKAVELLKAAQGSVKLVV 171
Score = 50.8 bits (116), Expect = 1e-05
Identities = 29/84 (34%), Positives = 51/84 (60%), Gaps = 4/84 (4%)
Query: 199 VDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLAD 258
V+L K GLG + G KE+ S I++ +I G A++ G +K D+++ V+G+S+
Sbjct: 94 VELPKTDEGLGFNIMG---GKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEG 150
Query: 259 KSNPQSVEILRNTGISVHLVLERY 282
+ + ++VE+L+ SV LV+ RY
Sbjct: 151 EQHEKAVELLKAAQGSVKLVV-RY 173
Score = 47.2 bits (107), Expect = 2e-04
Identities = 31/84 (36%), Positives = 41/84 (48%), Gaps = 7/84 (8%)
Query: 386 VAEIKKL-EGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEY 444
V E+ K EGLG + + GG+E YI V+P G G L GD+LL VN
Sbjct: 93 VVELPKTDEGLGFN------IMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGV 146
Query: 445 RLHGLTHSEVVNILKQLPDRVRLV 468
+ G H + V +LK V+LV
Sbjct: 147 SVEGEQHEKAVELLKAAQGSVKLV 170
>AL353639-2|CAI41237.1| 763|Homo sapiens multiple PDZ domain
protein protein.
Length = 763
Score = 66.1 bits (154), Expect = 4e-10
Identities = 79/289 (27%), Positives = 130/289 (44%), Gaps = 46/289 (15%)
Query: 365 VDKED-IVKKWK---EEIGS-DKEILVAEIKK-LEGLGISLEGTVDVEGGQELRPHHYIR 418
VDKED WK E G+ E+ + E++K GLG+SL G D R +I
Sbjct: 17 VDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGLGLSLAGNKD-----RSRMSVFIV 71
Query: 419 SVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGP 478
+ P+G G G L DELLE+N L+G +H +I+K P +V+++ RN
Sbjct: 72 GIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRN------ 125
Query: 479 RPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLE 538
+ VN + G + S S N L +++ ++ TS A K + LE
Sbjct: 126 KDAVNQMAVCPGNAVEPLPSNSEN----LQNKETEPTVTTSDAAV---DLSSFKNVQHLE 178
Query: 539 CVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEIS 598
L K GLG +I + +D + + ++++SL GVA +G +
Sbjct: 179 ----------------LPKDQGGLGIAISE-EDTL----SGVIIKSLTEHGVAATDGRLK 217
Query: 599 PGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPLPPQDSSKS 647
GD++++V+ + +++ + LK A + TVK+ I P + S
Sbjct: 218 VGDQILAVDDEIVVGYPIEKFISLLKTA-KMTVKLTIHAENPDSQAVPS 265
Score = 62.1 bits (144), Expect = 6e-09
Identities = 36/85 (42%), Positives = 50/85 (58%), Gaps = 2/85 (2%)
Query: 19 GNGLGFNLVGGRS-TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAVL 77
G GLG ++VG R+ TGV + ++ GG+AD D RL GD +L V ++R T E VAA+L
Sbjct: 426 GKGLGLSIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALL 485
Query: 78 RQAGPVVRLLVAR-PADPATALRAP 101
+ + V L V R A P + R P
Sbjct: 486 KCSLGTVTLEVGRIKAGPFHSERRP 510
Score = 57.6 bits (133), Expect = 1e-07
Identities = 32/85 (37%), Positives = 47/85 (55%), Gaps = 3/85 (3%)
Query: 13 VELTNDGNGLGFNLVGGRST---GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFT 69
+E++ GLG ++VGG T ++I V G A KD RL +GD +L+V ++LR T
Sbjct: 323 IEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKAT 382
Query: 70 SEQVAAVLRQAGPVVRLLVARPADP 94
++ VLRQ VRL + R P
Sbjct: 383 HDEAINVLRQTPQRVRLTLYRDEAP 407
Score = 57.2 bits (132), Expect = 2e-07
Identities = 63/278 (22%), Positives = 119/278 (42%), Gaps = 26/278 (9%)
Query: 377 EIGSDKEILVAEIKKLEG-LGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAG 435
++ S K + E+ K +G LGI++ + G I+S+ G G L G
Sbjct: 167 DLSSFKNVQHLELPKDQGGLGIAISEEDTLSGV-------IIKSLTEHGVAATDGRLKVG 219
Query: 436 DELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARK 495
D++L V++ + G + +++LK V+L + DS P A+ E
Sbjct: 220 DQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGE------ 273
Query: 496 IISGSLNNLTTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVML 555
N+ +L+ QS + ++ N S S + + + E + +
Sbjct: 274 ----KKNSSQSLMVPQS----GSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEI 325
Query: 556 VKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNAT 615
K GLG SI+ D + I++ + G A K+G + GD+++ VNG+ ++ AT
Sbjct: 326 SKGRTGLGLSIVGGSDTLLG---AIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKAT 382
Query: 616 LDQAVQALKGAPRGTVKVGIARPLPPQDSSKSKGTINV 653
D+A+ L+ P+ V++ + R P + T+ +
Sbjct: 383 HDEAINVLRQTPQ-RVRLTLYRDEAPYKEEEVCDTLTI 419
Score = 54.8 bits (126), Expect = 9e-07
Identities = 68/263 (25%), Positives = 113/263 (42%), Gaps = 34/263 (12%)
Query: 374 WKEEIGSDKEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLN 433
+KEE D + + K +GLG+S+ G + G ++ ++ G G L
Sbjct: 408 YKEEEVCDTLTIELQKKPGKGLGLSIVGKRNDTGV-------FVSDIVKGGIADADGRLM 460
Query: 434 AGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEA 493
GD++L VN + T V +LK V L R I +GP S+R ++
Sbjct: 461 QGDQILMVNGEDVRNATQEAVAALLKCSLGTVTLEVGR--IKAGP-----FHSERRPSQS 513
Query: 494 RKIISGSLNNLTTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIV 553
++ GSL++ T S ++T + SKK+ + GL + K+
Sbjct: 514 SQVSEGSLSSFT----------FPLSGSSTSESLESSSKKNALASEIQGLRTVEMKKG-- 561
Query: 554 MLVKADQGLGFSILDYQDPVDPNGTV-IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
LG SI P G V I + + P GVA + ++ GDR++++ G S +
Sbjct: 562 ----PTDSLGISIAGGVG--SPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTE 615
Query: 613 NATLDQAVQALKGAPRGTVKVGI 635
T QAV LK A G++++ +
Sbjct: 616 GMTHTQAVNLLKNA-SGSIEMQV 637
Score = 53.2 bits (122), Expect = 3e-06
Identities = 30/81 (37%), Positives = 47/81 (58%), Gaps = 6/81 (7%)
Query: 557 KADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATL 616
K +GLG SI+ + N T + V +V GG+A+ +G + GD+++ VNG ++NAT
Sbjct: 424 KPGKGLGLSIVGKR-----NDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNAT- 477
Query: 617 DQAVQALKGAPRGTVKVGIAR 637
+AV AL GTV + + R
Sbjct: 478 QEAVAALLKCSLGTVTLEVGR 498
Score = 52.4 bits (120), Expect = 5e-06
Identities = 28/85 (32%), Positives = 46/85 (54%), Gaps = 5/85 (5%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDHVLQVGSV 63
Q + + L +GLGF++VGG + + +K V G A +D RL+ GD ++ V
Sbjct: 677 QCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQ 736
Query: 64 NLRGFTSEQVAAVLRQAGPVVRLLV 88
+L G T E+ A+L++ V L+V
Sbjct: 737 SLEGVTHEEAVAILKRTKGTVTLMV 761
Score = 52.0 bits (119), Expect = 6e-06
Identities = 43/170 (25%), Positives = 82/170 (48%), Gaps = 17/170 (10%)
Query: 463 DRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTSSTA 522
DR+ +C ++ VNL + G ++++G +++ + Q + + ++ S
Sbjct: 604 DRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGG--DVSVVTGHQQEPASSSLSFT 661
Query: 523 TLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTV-IV 581
LT+ S +C S + L + GLGFSI+ P+G + I
Sbjct: 662 GLTSSSIFQDDLGPPQCKS-----------ITLERGPDGLGFSIVGGYG--SPHGDLPIY 708
Query: 582 VRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTV 631
V+++ G A ++G + GD++++VNG S++ T ++AV LK +GTV
Sbjct: 709 VKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILK-RTKGTV 757
Score = 50.0 bits (114), Expect = 3e-05
Identities = 28/104 (26%), Positives = 54/104 (51%), Gaps = 4/104 (3%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTGVVIKYVL---PGGVADKDRRLQSGDHVLQVGSVNL 65
++ ++EL +GLG +L G + + +++ P G A KD RLQ D +L++ L
Sbjct: 40 ELHMIELEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQIL 99
Query: 66 RGFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVP 109
G + + +++++ A V+++ R D + A PG A+ P
Sbjct: 100 YGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQM-AVCPGNAVEP 142
Score = 50.0 bits (114), Expect = 3e-05
Identities = 29/101 (28%), Positives = 57/101 (56%), Gaps = 6/101 (5%)
Query: 181 PTITIT-VPVELPEIEII-HVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQ 238
PT+T + V+L + + H++L K+ GLGI ++ E++ LSG+ +KS+ E A
Sbjct: 157 PTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAIS----EEDTLSGVIIKSLTEHGVAAT 212
Query: 239 SGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
G++K+ D+I+ VD + + + +L+ ++V L +
Sbjct: 213 DGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTI 253
Score = 47.6 bits (108), Expect = 1e-04
Identities = 30/106 (28%), Positives = 54/106 (50%), Gaps = 4/106 (3%)
Query: 178 SVSPTITITVPVELPEIEIIH--VDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSS 235
S +P I + P P I ++++K GLG+++ G L I + + E +
Sbjct: 300 SSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGG--SDTLLGAIIIHEVYEEGA 357
Query: 236 AEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
A + G++ D+I+EV+GI L ++ +++ +LR T V L L R
Sbjct: 358 ACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYR 403
Score = 46.4 bits (105), Expect = 3e-04
Identities = 35/138 (25%), Positives = 69/138 (50%), Gaps = 3/138 (2%)
Query: 143 INGQNGETETSIVAAA-VSVIGDNPQKIPDHPIVCDSVSPTITITVPVELPEIEIIHVDL 201
+ +G E +VA VSV+ + Q+ + ++ + + P+ + I ++
Sbjct: 626 LKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKSITLER 685
Query: 202 NKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSN 261
+ G I V GY +L I+VK++ +A + G++K D+II V+G SL ++
Sbjct: 686 GPDGLGFSI-VGGYGSPHGDLP-IYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTH 743
Query: 262 PQSVEILRNTGISVHLVL 279
++V IL+ T +V L++
Sbjct: 744 EEAVAILKRTKGTVTLMV 761
Score = 44.0 bits (99), Expect = 0.002
Identities = 27/85 (31%), Positives = 46/85 (54%), Gaps = 1/85 (1%)
Query: 5 TEWAQVEVVELTNDGNGLGFNLVGGRS-TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSV 63
+ + V+ +EL D GLG + + +GV+IK + GVA D RL+ GD +L V
Sbjct: 169 SSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDE 228
Query: 64 NLRGFTSEQVAAVLRQAGPVVRLLV 88
+ G+ E+ ++L+ A V+L +
Sbjct: 229 IVVGYPIEKFISLLKTAKMTVKLTI 253
Score = 43.6 bits (98), Expect = 0.002
Identities = 27/76 (35%), Positives = 38/76 (50%), Gaps = 3/76 (3%)
Query: 393 EGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHS 452
+GLG S+ G G P Y+++V G G L GD+++ VN L G+TH
Sbjct: 688 DGLGFSIVGGYGSPHGD--LPI-YVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHE 744
Query: 453 EVVNILKQLPDRVRLV 468
E V ILK+ V L+
Sbjct: 745 EAVAILKRTKGTVTLM 760
Score = 39.1 bits (87), Expect = 0.049
Identities = 21/70 (30%), Positives = 38/70 (54%)
Query: 208 LGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEI 267
LGI++AG V IF+ + A Q+ K+++ DRI+ + G S ++ Q+V +
Sbjct: 566 LGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNL 625
Query: 268 LRNTGISVHL 277
L+N S+ +
Sbjct: 626 LKNASGSIEM 635
Score = 38.7 bits (86), Expect = 0.064
Identities = 22/80 (27%), Positives = 43/80 (53%), Gaps = 4/80 (5%)
Query: 207 GLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVE 266
GLG+++ G K +G+FV I++G A+ G++ D+I+ V+G + + +
Sbjct: 428 GLGLSIVG----KRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAA 483
Query: 267 ILRNTGISVHLVLERYLRGP 286
+L+ + +V L + R GP
Sbjct: 484 LLKCSLGTVTLEVGRIKAGP 503
Score = 33.9 bits (74), Expect = 1.8
Identities = 23/97 (23%), Positives = 45/97 (46%), Gaps = 6/97 (6%)
Query: 3 LSTEWAQVEVVELTNDG-NGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDH 56
L++E + VE+ + LG ++ GG + + I + P GVA + ++L+ GD
Sbjct: 546 LASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDR 605
Query: 57 VLQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVARPAD 93
++ + + G T Q +L+ A + + V D
Sbjct: 606 IVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGD 642
>AL161449-2|CAI40491.1| 763|Homo sapiens multiple PDZ domain
protein protein.
Length = 763
Score = 66.1 bits (154), Expect = 4e-10
Identities = 79/289 (27%), Positives = 130/289 (44%), Gaps = 46/289 (15%)
Query: 365 VDKED-IVKKWK---EEIGS-DKEILVAEIKK-LEGLGISLEGTVDVEGGQELRPHHYIR 418
VDKED WK E G+ E+ + E++K GLG+SL G D R +I
Sbjct: 17 VDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGLGLSLAGNKD-----RSRMSVFIV 71
Query: 419 SVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGP 478
+ P+G G G L DELLE+N L+G +H +I+K P +V+++ RN
Sbjct: 72 GIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRN------ 125
Query: 479 RPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLE 538
+ VN + G + S S N L +++ ++ TS A K + LE
Sbjct: 126 KDAVNQMAVCPGNAVEPLPSNSEN----LQNKETEPTVTTSDAAV---DLSSFKNVQHLE 178
Query: 539 CVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEIS 598
L K GLG +I + +D + + ++++SL GVA +G +
Sbjct: 179 ----------------LPKDQGGLGIAISE-EDTL----SGVIIKSLTEHGVAATDGRLK 217
Query: 599 PGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPLPPQDSSKS 647
GD++++V+ + +++ + LK A + TVK+ I P + S
Sbjct: 218 VGDQILAVDDEIVVGYPIEKFISLLKTA-KMTVKLTIHAENPDSQAVPS 265
Score = 62.1 bits (144), Expect = 6e-09
Identities = 36/85 (42%), Positives = 50/85 (58%), Gaps = 2/85 (2%)
Query: 19 GNGLGFNLVGGRS-TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAVL 77
G GLG ++VG R+ TGV + ++ GG+AD D RL GD +L V ++R T E VAA+L
Sbjct: 426 GKGLGLSIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALL 485
Query: 78 RQAGPVVRLLVAR-PADPATALRAP 101
+ + V L V R A P + R P
Sbjct: 486 KCSLGTVTLEVGRIKAGPFHSERRP 510
Score = 57.6 bits (133), Expect = 1e-07
Identities = 32/85 (37%), Positives = 47/85 (55%), Gaps = 3/85 (3%)
Query: 13 VELTNDGNGLGFNLVGGRST---GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFT 69
+E++ GLG ++VGG T ++I V G A KD RL +GD +L+V ++LR T
Sbjct: 323 IEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKAT 382
Query: 70 SEQVAAVLRQAGPVVRLLVARPADP 94
++ VLRQ VRL + R P
Sbjct: 383 HDEAINVLRQTPQRVRLTLYRDEAP 407
Score = 57.2 bits (132), Expect = 2e-07
Identities = 63/278 (22%), Positives = 119/278 (42%), Gaps = 26/278 (9%)
Query: 377 EIGSDKEILVAEIKKLEG-LGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAG 435
++ S K + E+ K +G LGI++ + G I+S+ G G L G
Sbjct: 167 DLSSFKNVQHLELPKDQGGLGIAISEEDTLSGV-------IIKSLTEHGVAATDGRLKVG 219
Query: 436 DELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARK 495
D++L V++ + G + +++LK V+L + DS P A+ E
Sbjct: 220 DQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGE------ 273
Query: 496 IISGSLNNLTTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVML 555
N+ +L+ QS + ++ N S S + + + E + +
Sbjct: 274 ----KKNSSQSLMVPQS----GSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEI 325
Query: 556 VKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNAT 615
K GLG SI+ D + I++ + G A K+G + GD+++ VNG+ ++ AT
Sbjct: 326 SKGRTGLGLSIVGGSDTLLG---AIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKAT 382
Query: 616 LDQAVQALKGAPRGTVKVGIARPLPPQDSSKSKGTINV 653
D+A+ L+ P+ V++ + R P + T+ +
Sbjct: 383 HDEAINVLRQTPQ-RVRLTLYRDEAPYKEEEVCDTLTI 419
Score = 54.8 bits (126), Expect = 9e-07
Identities = 68/263 (25%), Positives = 113/263 (42%), Gaps = 34/263 (12%)
Query: 374 WKEEIGSDKEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLN 433
+KEE D + + K +GLG+S+ G + G ++ ++ G G L
Sbjct: 408 YKEEEVCDTLTIELQKKPGKGLGLSIVGKRNDTGV-------FVSDIVKGGIADADGRLM 460
Query: 434 AGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEA 493
GD++L VN + T V +LK V L R I +GP S+R ++
Sbjct: 461 QGDQILMVNGEDVRNATQEAVAALLKCSLGTVTLEVGR--IKAGP-----FHSERRPSQS 513
Query: 494 RKIISGSLNNLTTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIV 553
++ GSL++ T S ++T + SKK+ + GL + K+
Sbjct: 514 SQVSEGSLSSFT----------FPLSGSSTSESLESSSKKNALASEIQGLRTVEMKKG-- 561
Query: 554 MLVKADQGLGFSILDYQDPVDPNGTV-IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
LG SI P G V I + + P GVA + ++ GDR++++ G S +
Sbjct: 562 ----PTDSLGISIAGGVG--SPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTE 615
Query: 613 NATLDQAVQALKGAPRGTVKVGI 635
T QAV LK A G++++ +
Sbjct: 616 GMTHTQAVNLLKNA-SGSIEMQV 637
Score = 53.2 bits (122), Expect = 3e-06
Identities = 30/81 (37%), Positives = 47/81 (58%), Gaps = 6/81 (7%)
Query: 557 KADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATL 616
K +GLG SI+ + N T + V +V GG+A+ +G + GD+++ VNG ++NAT
Sbjct: 424 KPGKGLGLSIVGKR-----NDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNAT- 477
Query: 617 DQAVQALKGAPRGTVKVGIAR 637
+AV AL GTV + + R
Sbjct: 478 QEAVAALLKCSLGTVTLEVGR 498
Score = 52.4 bits (120), Expect = 5e-06
Identities = 28/85 (32%), Positives = 46/85 (54%), Gaps = 5/85 (5%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDHVLQVGSV 63
Q + + L +GLGF++VGG + + +K V G A +D RL+ GD ++ V
Sbjct: 677 QCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQ 736
Query: 64 NLRGFTSEQVAAVLRQAGPVVRLLV 88
+L G T E+ A+L++ V L+V
Sbjct: 737 SLEGVTHEEAVAILKRTKGTVTLMV 761
Score = 52.0 bits (119), Expect = 6e-06
Identities = 43/170 (25%), Positives = 82/170 (48%), Gaps = 17/170 (10%)
Query: 463 DRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTSSTA 522
DR+ +C ++ VNL + G ++++G +++ + Q + + ++ S
Sbjct: 604 DRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGG--DVSVVTGHQQEPASSSLSFT 661
Query: 523 TLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTV-IV 581
LT+ S +C S + L + GLGFSI+ P+G + I
Sbjct: 662 GLTSSSIFQDDLGPPQCKS-----------ITLERGPDGLGFSIVGGYG--SPHGDLPIY 708
Query: 582 VRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTV 631
V+++ G A ++G + GD++++VNG S++ T ++AV LK +GTV
Sbjct: 709 VKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILK-RTKGTV 757
Score = 50.0 bits (114), Expect = 3e-05
Identities = 28/104 (26%), Positives = 54/104 (51%), Gaps = 4/104 (3%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTGVVIKYVL---PGGVADKDRRLQSGDHVLQVGSVNL 65
++ ++EL +GLG +L G + + +++ P G A KD RLQ D +L++ L
Sbjct: 40 ELHMIELEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQIL 99
Query: 66 RGFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVP 109
G + + +++++ A V+++ R D + A PG A+ P
Sbjct: 100 YGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQM-AVCPGNAVEP 142
Score = 50.0 bits (114), Expect = 3e-05
Identities = 29/101 (28%), Positives = 57/101 (56%), Gaps = 6/101 (5%)
Query: 181 PTITIT-VPVELPEIEII-HVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQ 238
PT+T + V+L + + H++L K+ GLGI ++ E++ LSG+ +KS+ E A
Sbjct: 157 PTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAIS----EEDTLSGVIIKSLTEHGVAAT 212
Query: 239 SGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
G++K+ D+I+ VD + + + +L+ ++V L +
Sbjct: 213 DGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTI 253
Score = 47.6 bits (108), Expect = 1e-04
Identities = 30/106 (28%), Positives = 54/106 (50%), Gaps = 4/106 (3%)
Query: 178 SVSPTITITVPVELPEIEIIH--VDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSS 235
S +P I + P P I ++++K GLG+++ G L I + + E +
Sbjct: 300 SSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGG--SDTLLGAIIIHEVYEEGA 357
Query: 236 AEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
A + G++ D+I+EV+GI L ++ +++ +LR T V L L R
Sbjct: 358 ACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYR 403
Score = 46.4 bits (105), Expect = 3e-04
Identities = 35/138 (25%), Positives = 69/138 (50%), Gaps = 3/138 (2%)
Query: 143 INGQNGETETSIVAAA-VSVIGDNPQKIPDHPIVCDSVSPTITITVPVELPEIEIIHVDL 201
+ +G E +VA VSV+ + Q+ + ++ + + P+ + I ++
Sbjct: 626 LKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKSITLER 685
Query: 202 NKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSN 261
+ G I V GY +L I+VK++ +A + G++K D+II V+G SL ++
Sbjct: 686 GPDGLGFSI-VGGYGSPHGDLP-IYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTH 743
Query: 262 PQSVEILRNTGISVHLVL 279
++V IL+ T +V L++
Sbjct: 744 EEAVAILKRTKGTVTLMV 761
Score = 44.0 bits (99), Expect = 0.002
Identities = 27/85 (31%), Positives = 46/85 (54%), Gaps = 1/85 (1%)
Query: 5 TEWAQVEVVELTNDGNGLGFNLVGGRS-TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSV 63
+ + V+ +EL D GLG + + +GV+IK + GVA D RL+ GD +L V
Sbjct: 169 SSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDE 228
Query: 64 NLRGFTSEQVAAVLRQAGPVVRLLV 88
+ G+ E+ ++L+ A V+L +
Sbjct: 229 IVVGYPIEKFISLLKTAKMTVKLTI 253
Score = 43.6 bits (98), Expect = 0.002
Identities = 27/76 (35%), Positives = 38/76 (50%), Gaps = 3/76 (3%)
Query: 393 EGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHS 452
+GLG S+ G G P Y+++V G G L GD+++ VN L G+TH
Sbjct: 688 DGLGFSIVGGYGSPHGD--LPI-YVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHE 744
Query: 453 EVVNILKQLPDRVRLV 468
E V ILK+ V L+
Sbjct: 745 EAVAILKRTKGTVTLM 760
Score = 39.1 bits (87), Expect = 0.049
Identities = 21/70 (30%), Positives = 38/70 (54%)
Query: 208 LGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEI 267
LGI++AG V IF+ + A Q+ K+++ DRI+ + G S ++ Q+V +
Sbjct: 566 LGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNL 625
Query: 268 LRNTGISVHL 277
L+N S+ +
Sbjct: 626 LKNASGSIEM 635
Score = 38.7 bits (86), Expect = 0.064
Identities = 22/80 (27%), Positives = 43/80 (53%), Gaps = 4/80 (5%)
Query: 207 GLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVE 266
GLG+++ G K +G+FV I++G A+ G++ D+I+ V+G + + +
Sbjct: 428 GLGLSIVG----KRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAA 483
Query: 267 ILRNTGISVHLVLERYLRGP 286
+L+ + +V L + R GP
Sbjct: 484 LLKCSLGTVTLEVGRIKAGP 503
Score = 33.9 bits (74), Expect = 1.8
Identities = 23/97 (23%), Positives = 45/97 (46%), Gaps = 6/97 (6%)
Query: 3 LSTEWAQVEVVELTNDG-NGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDH 56
L++E + VE+ + LG ++ GG + + I + P GVA + ++L+ GD
Sbjct: 546 LASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDR 605
Query: 57 VLQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVARPAD 93
++ + + G T Q +L+ A + + V D
Sbjct: 606 IVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGD 642
>AF311862-1|AAG34117.1| 207|Homo sapiens Lin-7b protein.
Length = 207
Score = 66.1 bits (154), Expect = 4e-10
Identities = 33/82 (40%), Positives = 57/82 (69%), Gaps = 5/82 (6%)
Query: 552 IVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSI 611
+V L K D+GLGF+I+ ++ P I + ++PGGVA+++G + GD+++SVNGVS+
Sbjct: 93 VVELPKTDEGLGFNIMGGKEQNSP----IYISRVIPGGVADRHGGLKRGDQLLSVNGVSV 148
Query: 612 QNATLDQAVQALKGAPRGTVKV 633
+ ++AV+ LK A +G+VK+
Sbjct: 149 EGEQHEKAVELLKAA-QGSVKL 169
Score = 62.1 bits (144), Expect = 6e-09
Identities = 33/83 (39%), Positives = 50/83 (60%), Gaps = 2/83 (2%)
Query: 8 AQVEVVELTNDGNGLGFNLVGGR--STGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
A VVEL GLGFN++GG+ ++ + I V+PGGVAD+ L+ GD +L V V++
Sbjct: 89 AHPRVVELPKTDEGLGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSV 148
Query: 66 RGFTSEQVAAVLRQAGPVVRLLV 88
G E+ +L+ A V+L+V
Sbjct: 149 EGEQHEKAVELLKAAQGSVKLVV 171
Score = 50.8 bits (116), Expect = 1e-05
Identities = 29/84 (34%), Positives = 51/84 (60%), Gaps = 4/84 (4%)
Query: 199 VDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLAD 258
V+L K GLG + G KE+ S I++ +I G A++ G +K D+++ V+G+S+
Sbjct: 94 VELPKTDEGLGFNIMG---GKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEG 150
Query: 259 KSNPQSVEILRNTGISVHLVLERY 282
+ + ++VE+L+ SV LV+ RY
Sbjct: 151 EQHEKAVELLKAAQGSVKLVV-RY 173
Score = 47.2 bits (107), Expect = 2e-04
Identities = 31/84 (36%), Positives = 41/84 (48%), Gaps = 7/84 (8%)
Query: 386 VAEIKKL-EGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEY 444
V E+ K EGLG + + GG+E YI V+P G G L GD+LL VN
Sbjct: 93 VVELPKTDEGLGFN------IMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGV 146
Query: 445 RLHGLTHSEVVNILKQLPDRVRLV 468
+ G H + V +LK V+LV
Sbjct: 147 SVEGEQHEKAVELLKAAQGSVKLV 170
>AF401656-1|AAK94066.1| 1462|Homo sapiens MAGI-1C beta protein.
Length = 1462
Score = 65.7 bits (153), Expect = 5e-10
Identities = 150/668 (22%), Positives = 262/668 (39%), Gaps = 89/668 (13%)
Query: 14 ELTNDGNGLGFNLVGGRSTG--VVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSE 71
+L G GF +VGG + IK ++ G A D ++++GD ++ V + G T
Sbjct: 474 KLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHA 533
Query: 72 QVAAVLRQA--GPVVRLLVAR----PADPATALRAPQPGTALVPTKILADPELLDRHLIE 125
QV + + G V L + R P DP P T+LV + + D E + + E
Sbjct: 534 QVVKIFQSIPIGASVDLELCRGYPLPFDP------DDPNTSLVTSVAILDKEPIIVNGQE 587
Query: 126 TGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQKIPDHPIVCDSVSPTITI 185
T YD +S G+ + + ++ V ++ P+ D+VS +I
Sbjct: 588 T-----YDSPASHSSKT--GKVNGMKDARPSSPADVASNSSHGYPN-----DTVSLASSI 635
Query: 186 TVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKIN 245
EL + I+ K G G T+A + G VK I++ +K
Sbjct: 636 ATQPELITVHIV-----KGPMGFGFTIA----DSPGGGGQRVKQIVDSPRCRG---LKEG 683
Query: 246 DRIIEVDGISLADKSNPQSVEILRNT--GISVHLVLERY-----LRGPKFEHLQLAIFNE 298
D I+EV+ ++ ++ Q V++L G V L+++R + PK + L+ +
Sbjct: 684 DLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERK--DS 741
Query: 299 ERXXXXXXXXXXLSWFPVPSQLENSITEIEP-EPESNTTIDSSVLEVGDLQEPTQEELDQ 357
+ PS + E P E ++ DSS + D + +
Sbjct: 742 QNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSM 801
Query: 358 RFDEILAVDKEDIVKKWKEEIGSDKEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYI 417
+ + ++DI W++E G IL GG E YI
Sbjct: 802 YENRLPDYQEQDIFL-WRKETGFGFRIL---------------------GGNEPGEPIYI 839
Query: 418 RSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDR--VRLVCARNSID 475
++P G G L +GDEL+ V+ + G +H VV +++Q + V L R +
Sbjct: 840 GHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVF 899
Query: 476 SGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTSSTATLTNHSEQSKKSR 535
+ P+ + S + + T +Q+ S+NT S+ + + S
Sbjct: 900 AVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQN--SLNTVSSGSGSTSGIGSGGGG 957
Query: 536 SLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPN---GTVIV-----VRSLVP 587
VS + D+ + ++G GF I+ + G V + ++
Sbjct: 958 GSGVVSTVVQ---PYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIE 1014
Query: 588 GGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPLPPQDSSKS 647
G A++ G++ GDR+++VNG SI N + V +K A TV + R +P +SS +
Sbjct: 1015 GSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEA-GNTVTL---RIIPGDESSNA 1070
Query: 648 KGTINVNK 655
N K
Sbjct: 1071 TLLTNAEK 1078
Score = 62.9 bits (146), Expect = 3e-09
Identities = 100/458 (21%), Positives = 186/458 (40%), Gaps = 46/458 (10%)
Query: 195 EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGI 254
+ IH L K+ G G TV G E +E + +KS++ A GK++ D I+ V+
Sbjct: 469 KFIHTKLRKSSRGFGFTVVGGD-EPDEF--LQIKSLVLDGPAALDGKMETGDVIVSVNDT 525
Query: 255 SLADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHLQLAIFNEERXXXXXXXXXXLSWF 314
+ ++ Q V+I ++ I + LE RG L ++ L
Sbjct: 526 CVLGHTHAQVVKIFQSIPIGASVDLE-LCRG-----YPLPFDPDDPNTSLVTSVAILDKE 579
Query: 315 PVPSQLENSITEIEPEPESNTTIDSSVLEVGDLQEPTQEELDQRFDEILAVDKEDIVKKW 374
P+ + N E P S+++ V + D + + ++ D +
Sbjct: 580 PI---IVNG-QETYDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASS- 634
Query: 375 KEEIGSDKEILVAEIKKLE-GLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLN 433
I + E++ I K G G ++ D GG R ++ ++ D P +G L
Sbjct: 635 ---IATQPELITVHIVKGPMGFGFTI---ADSPGGGGQR----VKQIV-DSP-RCRG-LK 681
Query: 434 AGDELLEVNEYRLHGLTHSEVVNILKQLP--DRVRLVCARNSIDSGPRPVVNLASDREGF 491
GD ++EVN+ + LTH++VV++L + P V L+ R + + + +R+
Sbjct: 682 EGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDS 741
Query: 492 EARKIISGSLNNLTTLVKAQSDTSI------NTSSTATLTNHSEQSKKSRSLECVSGLAM 545
+ S S + T + + T+ S Q K +M
Sbjct: 742 QNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSM 801
Query: 546 WQSK-----EDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPG 600
++++ E + L + + G GF IL +P +P I + +VP G A+ +G + G
Sbjct: 802 YENRLPDYQEQDIFLWRKETGFGFRILGGNEPGEP----IYIGHIVPLGAADTDGRLRSG 857
Query: 601 DRVMSVNGVSIQNATLDQAVQAL-KGAPRGTVKVGIAR 637
D ++ V+G + + VQ + + A +G V + + R
Sbjct: 858 DELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRR 895
Score = 50.0 bits (114), Expect = 3e-05
Identities = 26/94 (27%), Positives = 51/94 (54%), Gaps = 3/94 (3%)
Query: 188 PVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDR 247
P E + V+L + G G ++ G +E ++V + E AE+ GK++I D
Sbjct: 1113 PQATQEQDFYTVELERGAKGFGFSLRG---GREYNMDLYVLRLAEDGPAERCGKMRIGDE 1169
Query: 248 IIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
I+E++G + + + +++E+++N G V L L+R
Sbjct: 1170 ILEINGETTKNMKHSRAIELIKNGGRRVRLFLKR 1203
Score = 50.0 bits (114), Expect = 3e-05
Identities = 33/111 (29%), Positives = 52/111 (46%), Gaps = 10/111 (9%)
Query: 381 DKEILVAEIKK-LEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELL 439
+++ E+++ +G G SL G G+E Y+ + DGP G + GDE+L
Sbjct: 1118 EQDFYTVELERGAKGFGFSLRG------GREYNMDLYVLRLAEDGPAERCGKMRIGDEIL 1171
Query: 440 EVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREG 490
E+N + HS + ++K RVRL R G P + +SDR G
Sbjct: 1172 EINGETTKNMKHSRAIELIKNGGRRVRLFLKRG---DGSVPEYDPSSDRHG 1219
Score = 48.0 bits (109), Expect = 1e-04
Identities = 33/105 (31%), Positives = 52/105 (49%), Gaps = 7/105 (6%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTG--VVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLR 66
Q + + L G GF ++GG G + I +++P G AD D RL+SGD ++ V +
Sbjct: 810 QEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVI 869
Query: 67 GFTSEQVAAVLRQAGPV--VRLLVARP---ADPATALRAPQPGTA 106
G + + V +++QA V L V R A P T P P ++
Sbjct: 870 GKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASS 914
Score = 47.6 bits (108), Expect = 1e-04
Identities = 42/172 (24%), Positives = 78/172 (45%), Gaps = 10/172 (5%)
Query: 463 DRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGS-LNNLTTLVKAQSDTSINTSST 521
DR+ V + + +VNL + +II G +N T L A+ +I T+ T
Sbjct: 1028 DRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHT 1087
Query: 522 ATL-----TNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPN 576
+ T ++ + K+ E + A + V L + +G GFS+ ++ N
Sbjct: 1088 PSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREY---N 1144
Query: 577 GTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPR 628
+ V+R L G AE+ G++ GD ++ +NG + +N +A++ +K R
Sbjct: 1145 MDLYVLR-LAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGR 1195
Score = 44.8 bits (101), Expect = 0.001
Identities = 34/134 (25%), Positives = 60/134 (44%), Gaps = 11/134 (8%)
Query: 4 STEWAQVEVVELTNDGNGLGFNLVGGRSTGVVIKYVL---PGGVADKDRRLQSGDHVLQV 60
+T+ VEL G GF+L GGR + + YVL G A++ +++ GD +L++
Sbjct: 1115 ATQEQDFYTVELERGAKGFGFSLRGGREYNMDL-YVLRLAEDGPAERCGKMRIGDEILEI 1173
Query: 61 GSVNLRGFTSEQVAAVLRQAGPVVRLLVAR------PADPATALRAPQPGTALVPTKILA 114
+ + +++ G VRL + R DP++ P G VP ++ A
Sbjct: 1174 NGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYDPSSDRHGPATGPQGVP-EVRA 1232
Query: 115 DPELLDRHLIETGY 128
P+ +E+ Y
Sbjct: 1233 GPDRRQHPSLESSY 1246
>AJ401189-1|CAC37685.1| 817|Homo sapiens neurabin II protein
protein.
Length = 817
Score = 65.3 bits (152), Expect = 6e-10
Identities = 33/98 (33%), Positives = 57/98 (58%), Gaps = 3/98 (3%)
Query: 177 DSVSPTITITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKE---ELSGIFVKSIIEG 233
D ++ + + + +E+ V+L K+ GLGI++ G + E GIFVK++ EG
Sbjct: 473 DPMAASAEYELEKRVERLELFPVELEKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEG 532
Query: 234 SSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
+A + G+I++ND ++EVDG SL + + +LRNT
Sbjct: 533 GAAHRDGRIQVNDLLVEVDGTSLVGVTQSFAASVLRNT 570
Score = 45.6 bits (103), Expect = 6e-04
Identities = 28/81 (34%), Positives = 40/81 (49%), Gaps = 8/81 (9%)
Query: 13 VELTNDGNGLGFNLVGG--------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
VEL D GLG +++G G+ +K V GG A +D R+Q D +++V +
Sbjct: 495 VELEKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTS 554
Query: 65 LRGFTSEQVAAVLRQAGPVVR 85
L G T A+VLR VR
Sbjct: 555 LVGVTQSFAASVLRNTKGRVR 575
Score = 41.9 bits (94), Expect = 0.007
Identities = 38/143 (26%), Positives = 68/143 (47%), Gaps = 9/143 (6%)
Query: 328 EPEPESNTTIDSSVLEVGDLQEPTQEELDQRFDEI--LAVDKEDIVKKWKEEIGSDKEIL 385
E +P + I S + + E+ D+R +++ +A E ++K E + E+
Sbjct: 438 EEDPAPSRKIHFSTAPIQVFSTYSNEDYDRRNEDVDPMAASAEYELEKRVERL----ELF 493
Query: 386 VAEIKK-LEGLGISLEGT-VDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNE 443
E++K EGLGIS+ G + G E + ++++V G G + D L+EV+
Sbjct: 494 PVELEKDSEGLGISIIGMGAGADMGLE-KLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDG 552
Query: 444 YRLHGLTHSEVVNILKQLPDRVR 466
L G+T S ++L+ RVR
Sbjct: 553 TSLVGVTQSFAASVLRNTKGRVR 575
Score = 39.1 bits (87), Expect = 0.049
Identities = 29/91 (31%), Positives = 41/91 (45%), Gaps = 5/91 (5%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPN--GTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVS 610
V L K +GLG SI+ D I V+++ GG A ++G I D ++ V+G S
Sbjct: 495 VELEKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTS 554
Query: 611 IQNATLDQAVQAL---KGAPRGTVKVGIARP 638
+ T A L KG R +G RP
Sbjct: 555 LVGVTQSFAASVLRNTKGRVRCRFMIGRERP 585
>AF338650-1|AAK07661.1| 2641|Homo sapiens PDZ domain-containing
protein AIPC protein.
Length = 2641
Score = 64.9 bits (151), Expect = 9e-10
Identities = 66/244 (27%), Positives = 105/244 (43%), Gaps = 39/244 (15%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
+K +GLG S+ G D GQ +++++ P+G G L GDE+L+VN + GL
Sbjct: 412 EKGKGLGFSIAGGRDCIRGQM---GIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGL 468
Query: 450 THSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLN--NLTTL 507
T E ++ KQ+ + ++ R K++S SL + T
Sbjct: 469 TFQEAIHTFKQIRSGLFVLTVRT----------------------KLVSPSLTPCSTPTH 506
Query: 508 VKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQ----GLG 563
+ + + NTS A+ E S S G K+ IVM V ++ GLG
Sbjct: 507 MSRSASPNFNTSGGASAGGSDEGSSSS------LGRKTPGPKDRIVMEVTLNKEPRVGLG 560
Query: 564 FSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQAL 623
P G I + SL PG VA+ +S GD+++ VN V++++A L + L
Sbjct: 561 IGACCLALENSPPG--IYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAIL 618
Query: 624 KGAP 627
P
Sbjct: 619 SKCP 622
Score = 52.0 bits (119), Expect = 6e-06
Identities = 25/77 (32%), Positives = 41/77 (53%), Gaps = 5/77 (6%)
Query: 19 GNGLGFNLVGGRST-----GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQV 73
G GLGF++ GGR G+ +K + P G A +D RL+ GD +L V + ++G T ++
Sbjct: 414 GKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEA 473
Query: 74 AAVLRQAGPVVRLLVAR 90
+Q + +L R
Sbjct: 474 IHTFKQIRSGLFVLTVR 490
Score = 48.8 bits (111), Expect = 6e-05
Identities = 32/99 (32%), Positives = 52/99 (52%), Gaps = 8/99 (8%)
Query: 532 KKSRSLECVSGLAMWQ----SKEDIVMLVKAD-QGLGFSILDYQDPVDPNGTV-IVVRSL 585
K +RSL + W+ S I+ L K +GLGFSI +D + G + I V+++
Sbjct: 382 KSTRSLSTTQVESPWRLIRPSVISIIGLYKEKGKGLGFSIAGGRDCI--RGQMGIFVKTI 439
Query: 586 VPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
P G A ++G + GD ++ VNG+ I+ T +A+ K
Sbjct: 440 FPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFK 478
Score = 48.4 bits (110), Expect = 8e-05
Identities = 37/109 (33%), Positives = 50/109 (45%), Gaps = 7/109 (6%)
Query: 373 KWKEEIGSDKEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVL 432
K + E D +V K+ GLG S+ G DVE + + H V G +G +
Sbjct: 2413 KAQSENEEDVCFIVLNRKEGSGLGFSVAGGTDVEP-KSITVHR----VFSQGAASQEGTM 2467
Query: 433 NAGDELLEVNEYRLHGLTHSEVVNILKQLP-DRVRLVCARNSIDSGPRP 480
N GD LL VN L GL H V+ +L Q + LV + +D PRP
Sbjct: 2468 NRGDFLLSVNGASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQ-PRP 2515
Score = 46.0 bits (104), Expect = 4e-04
Identities = 29/81 (35%), Positives = 42/81 (51%), Gaps = 5/81 (6%)
Query: 384 ILVAEIKKLEGLGISLEG-TVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVN 442
+ V +K GLG+SL+G V G L I+ V G G++ AGDE+L +N
Sbjct: 2551 LCVEVLKTSAGLGLSLDGGKSSVTGDGPL----VIKRVYKGGAAEQAGIIEAGDEILAIN 2606
Query: 443 EYRLHGLTHSEVVNILKQLPD 463
L GL H + NI+K +P+
Sbjct: 2607 GKPLVGLMHFDAWNIMKSVPE 2627
Score = 45.6 bits (103), Expect = 6e-04
Identities = 30/107 (28%), Positives = 53/107 (49%), Gaps = 1/107 (0%)
Query: 531 SKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGV 590
S+K+ LE G ++ V ++K GLG S+ + V +G +++ R + GG
Sbjct: 2531 SRKTIPLEPGIGRSVAVHDALCVEVLKTSAGLGLSLDGGKSSVTGDGPLVIKR-VYKGGA 2589
Query: 591 AEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIAR 637
AE+ G I GD ++++NG + A +K P G V++ I +
Sbjct: 2590 AEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPEGPVQLLIRK 2636
Score = 41.5 bits (93), Expect = 0.009
Identities = 21/51 (41%), Positives = 34/51 (66%), Gaps = 2/51 (3%)
Query: 207 GLGITVAG-YVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISL 256
GLG ++AG C + ++ GIFVK+I SA + G++K D I++V+GI +
Sbjct: 416 GLGFSIAGGRDCIRGQM-GIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPI 465
Score = 40.3 bits (90), Expect = 0.021
Identities = 21/66 (31%), Positives = 32/66 (48%), Gaps = 3/66 (4%)
Query: 18 DGNGLGFNLVGGRST---GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVA 74
+G+GLGF++ GG + + V G A ++ + GD +L V +L G V
Sbjct: 2431 EGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNVL 2490
Query: 75 AVLRQA 80
VL QA
Sbjct: 2491 KVLHQA 2496
Score = 39.1 bits (87), Expect = 0.049
Identities = 34/123 (27%), Positives = 54/123 (43%), Gaps = 9/123 (7%)
Query: 33 GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAVLRQAGPV----VRLLV 88
G+ I + PG VA + L GD +L+V SVN+R +V A+L + PV + ++
Sbjct: 574 GIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKC-PVSEQEMDEVI 632
Query: 89 ARPA--DPATALRAPQPGTALVPTKILADPELLDRHLIETGYGAVYDLSQCYSDYNINGQ 146
AR + A +P GT L + L+ E +D+ SD+ + G
Sbjct: 633 ARSTYQESKEANSSPGLGTPLKSPSLAKKDSLISES--ELSQYFAHDVPGPLSDFMVAGS 690
Query: 147 NGE 149
E
Sbjct: 691 EDE 693
Score = 37.5 bits (83), Expect = 0.15
Identities = 27/82 (32%), Positives = 42/82 (51%), Gaps = 7/82 (8%)
Query: 13 VELTNDGNGLGFNLVGGRS--TG---VVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
VE+ GLG +L GG+S TG +VIK V GG A++ +++GD +L + L G
Sbjct: 2553 VEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVG 2612
Query: 68 FTSEQVAAVLRQA--GPVVRLL 87
+++ GPV L+
Sbjct: 2613 LMHFDAWNIMKSVPEGPVQLLI 2634
Score = 33.1 bits (72), Expect = 3.2
Identities = 19/62 (30%), Positives = 32/62 (51%), Gaps = 2/62 (3%)
Query: 196 IIHVDLNKNV-YGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGI 254
++ V LNK GLGI E GI++ S+ GS A+ + D+I+EV+ +
Sbjct: 546 VMEVTLNKEPRVGLGIGACCLALENSP-PGIYIHSLAPGSVAKMESNLSRGDQILEVNSV 604
Query: 255 SL 256
++
Sbjct: 605 NV 606
Score = 31.9 bits (69), Expect = 7.4
Identities = 23/77 (29%), Positives = 38/77 (49%), Gaps = 3/77 (3%)
Query: 193 EIEIIHVDLN-KNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEV 251
E ++ + LN K GLG +VAG E I V + +A Q G + D ++ V
Sbjct: 2419 EEDVCFIVLNRKEGSGLGFSVAGGT--DVEPKSITVHRVFSQGAASQEGTMNRGDFLLSV 2476
Query: 252 DGISLADKSNPQSVEIL 268
+G SLA ++ +++L
Sbjct: 2477 NGASLAGLAHGNVLKVL 2493
>BC122561-1|AAI22562.1| 233|Homo sapiens lin-7 homolog A (C.
elegans) protein.
Length = 233
Score = 64.5 bits (150), Expect = 1e-09
Identities = 32/82 (39%), Positives = 56/82 (68%), Gaps = 5/82 (6%)
Query: 552 IVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSI 611
+V L K D+GLGF+++ ++ P I + ++PGGVAE++G + GD+++SVNGVS+
Sbjct: 108 VVELPKTDEGLGFNVMGGKEQNSP----IYISRIIPGGVAERHGGLKRGDQLLSVNGVSV 163
Query: 612 QNATLDQAVQALKGAPRGTVKV 633
+ ++AV+ LK A + +VK+
Sbjct: 164 EGEHHEKAVELLKAA-KDSVKL 184
Score = 58.8 bits (136), Expect = 6e-08
Identities = 30/79 (37%), Positives = 49/79 (62%), Gaps = 2/79 (2%)
Query: 12 VVELTNDGNGLGFNLVGGR--STGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFT 69
VVEL GLGFN++GG+ ++ + I ++PGGVA++ L+ GD +L V V++ G
Sbjct: 108 VVELPKTDEGLGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEH 167
Query: 70 SEQVAAVLRQAGPVVRLLV 88
E+ +L+ A V+L+V
Sbjct: 168 HEKAVELLKAAKDSVKLVV 186
Score = 52.8 bits (121), Expect = 4e-06
Identities = 32/84 (38%), Positives = 51/84 (60%), Gaps = 4/84 (4%)
Query: 199 VDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLAD 258
V+L K GLG V G KE+ S I++ II G AE+ G +K D+++ V+G+S+
Sbjct: 109 VELPKTDEGLGFNVMG---GKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEG 165
Query: 259 KSNPQSVEILRNTGISVHLVLERY 282
+ + ++VE+L+ SV LV+ RY
Sbjct: 166 EHHEKAVELLKAAKDSVKLVV-RY 188
Score = 49.2 bits (112), Expect = 5e-05
Identities = 32/84 (38%), Positives = 42/84 (50%), Gaps = 7/84 (8%)
Query: 386 VAEIKKL-EGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEY 444
V E+ K EGLG + V GG+E YI ++P G G L GD+LL VN
Sbjct: 108 VVELPKTDEGLGFN------VMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGV 161
Query: 445 RLHGLTHSEVVNILKQLPDRVRLV 468
+ G H + V +LK D V+LV
Sbjct: 162 SVEGEHHEKAVELLKAAKDSVKLV 185
>BC118609-1|AAI18610.1| 233|Homo sapiens lin-7 homolog A (C.
elegans) protein.
Length = 233
Score = 64.5 bits (150), Expect = 1e-09
Identities = 32/82 (39%), Positives = 56/82 (68%), Gaps = 5/82 (6%)
Query: 552 IVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSI 611
+V L K D+GLGF+++ ++ P I + ++PGGVAE++G + GD+++SVNGVS+
Sbjct: 108 VVELPKTDEGLGFNVMGGKEQNSP----IYISRIIPGGVAERHGGLKRGDQLLSVNGVSV 163
Query: 612 QNATLDQAVQALKGAPRGTVKV 633
+ ++AV+ LK A + +VK+
Sbjct: 164 EGEHHEKAVELLKAA-KDSVKL 184
Score = 58.8 bits (136), Expect = 6e-08
Identities = 30/79 (37%), Positives = 49/79 (62%), Gaps = 2/79 (2%)
Query: 12 VVELTNDGNGLGFNLVGGR--STGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFT 69
VVEL GLGFN++GG+ ++ + I ++PGGVA++ L+ GD +L V V++ G
Sbjct: 108 VVELPKTDEGLGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEH 167
Query: 70 SEQVAAVLRQAGPVVRLLV 88
E+ +L+ A V+L+V
Sbjct: 168 HEKAVELLKAAKDSVKLVV 186
Score = 52.8 bits (121), Expect = 4e-06
Identities = 32/84 (38%), Positives = 51/84 (60%), Gaps = 4/84 (4%)
Query: 199 VDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLAD 258
V+L K GLG V G KE+ S I++ II G AE+ G +K D+++ V+G+S+
Sbjct: 109 VELPKTDEGLGFNVMG---GKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEG 165
Query: 259 KSNPQSVEILRNTGISVHLVLERY 282
+ + ++VE+L+ SV LV+ RY
Sbjct: 166 EHHEKAVELLKAAKDSVKLVV-RY 188
Score = 49.2 bits (112), Expect = 5e-05
Identities = 32/84 (38%), Positives = 42/84 (50%), Gaps = 7/84 (8%)
Query: 386 VAEIKKL-EGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEY 444
V E+ K EGLG + V GG+E YI ++P G G L GD+LL VN
Sbjct: 108 VVELPKTDEGLGFN------VMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGV 161
Query: 445 RLHGLTHSEVVNILKQLPDRVRLV 468
+ G H + V +LK D V+LV
Sbjct: 162 SVEGEHHEKAVELLKAAKDSVKLV 185
>BC099921-1|AAH99921.1| 233|Homo sapiens lin-7 homolog A (C.
elegans) protein.
Length = 233
Score = 64.5 bits (150), Expect = 1e-09
Identities = 32/82 (39%), Positives = 56/82 (68%), Gaps = 5/82 (6%)
Query: 552 IVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSI 611
+V L K D+GLGF+++ ++ P I + ++PGGVAE++G + GD+++SVNGVS+
Sbjct: 108 VVELPKTDEGLGFNVMGGKEQNSP----IYISRIIPGGVAERHGGLKRGDQLLSVNGVSV 163
Query: 612 QNATLDQAVQALKGAPRGTVKV 633
+ ++AV+ LK A + +VK+
Sbjct: 164 EGEHHEKAVELLKAA-KDSVKL 184
Score = 58.8 bits (136), Expect = 6e-08
Identities = 30/79 (37%), Positives = 49/79 (62%), Gaps = 2/79 (2%)
Query: 12 VVELTNDGNGLGFNLVGGR--STGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFT 69
VVEL GLGFN++GG+ ++ + I ++PGGVA++ L+ GD +L V V++ G
Sbjct: 108 VVELPKTDEGLGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEH 167
Query: 70 SEQVAAVLRQAGPVVRLLV 88
E+ +L+ A V+L+V
Sbjct: 168 HEKAVELLKAAKDSVKLVV 186
Score = 52.8 bits (121), Expect = 4e-06
Identities = 32/84 (38%), Positives = 51/84 (60%), Gaps = 4/84 (4%)
Query: 199 VDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLAD 258
V+L K GLG V G KE+ S I++ II G AE+ G +K D+++ V+G+S+
Sbjct: 109 VELPKTDEGLGFNVMG---GKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEG 165
Query: 259 KSNPQSVEILRNTGISVHLVLERY 282
+ + ++VE+L+ SV LV+ RY
Sbjct: 166 EHHEKAVELLKAAKDSVKLVV-RY 188
Score = 49.2 bits (112), Expect = 5e-05
Identities = 32/84 (38%), Positives = 42/84 (50%), Gaps = 7/84 (8%)
Query: 386 VAEIKKL-EGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEY 444
V E+ K EGLG + V GG+E YI ++P G G L GD+LL VN
Sbjct: 108 VVELPKTDEGLGFN------VMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGV 161
Query: 445 RLHGLTHSEVVNILKQLPDRVRLV 468
+ G H + V +LK D V+LV
Sbjct: 162 SVEGEHHEKAVELLKAAKDSVKLV 185
>AF173081-1|AAD48500.1| 233|Homo sapiens LIN-7 homolog 1 protein.
Length = 233
Score = 64.5 bits (150), Expect = 1e-09
Identities = 32/82 (39%), Positives = 56/82 (68%), Gaps = 5/82 (6%)
Query: 552 IVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSI 611
+V L K D+GLGF+++ ++ P I + ++PGGVAE++G + GD+++SVNGVS+
Sbjct: 108 VVELPKTDEGLGFNVMGGKEQNSP----IYISRIIPGGVAERHGGLKRGDQLLSVNGVSV 163
Query: 612 QNATLDQAVQALKGAPRGTVKV 633
+ ++AV+ LK A + +VK+
Sbjct: 164 EGEHHEKAVELLKAA-KDSVKL 184
Score = 58.8 bits (136), Expect = 6e-08
Identities = 30/79 (37%), Positives = 49/79 (62%), Gaps = 2/79 (2%)
Query: 12 VVELTNDGNGLGFNLVGGR--STGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFT 69
VVEL GLGFN++GG+ ++ + I ++PGGVA++ L+ GD +L V V++ G
Sbjct: 108 VVELPKTDEGLGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEH 167
Query: 70 SEQVAAVLRQAGPVVRLLV 88
E+ +L+ A V+L+V
Sbjct: 168 HEKAVELLKAAKDSVKLVV 186
Score = 52.8 bits (121), Expect = 4e-06
Identities = 32/84 (38%), Positives = 51/84 (60%), Gaps = 4/84 (4%)
Query: 199 VDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLAD 258
V+L K GLG V G KE+ S I++ II G AE+ G +K D+++ V+G+S+
Sbjct: 109 VELPKTDEGLGFNVMG---GKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEG 165
Query: 259 KSNPQSVEILRNTGISVHLVLERY 282
+ + ++VE+L+ SV LV+ RY
Sbjct: 166 EHHEKAVELLKAAKDSVKLVV-RY 188
Score = 49.2 bits (112), Expect = 5e-05
Identities = 32/84 (38%), Positives = 42/84 (50%), Gaps = 7/84 (8%)
Query: 386 VAEIKKL-EGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEY 444
V E+ K EGLG + V GG+E YI ++P G G L GD+LL VN
Sbjct: 108 VVELPKTDEGLGFN------VMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGV 161
Query: 445 RLHGLTHSEVVNILKQLPDRVRLV 468
+ G H + V +LK D V+LV
Sbjct: 162 SVEGEHHEKAVELLKAAKDSVKLV 185
>AF087693-1|AAC78481.1| 233|Homo sapiens veli 1 protein.
Length = 233
Score = 64.5 bits (150), Expect = 1e-09
Identities = 32/82 (39%), Positives = 56/82 (68%), Gaps = 5/82 (6%)
Query: 552 IVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSI 611
+V L K D+GLGF+++ ++ P I + ++PGGVAE++G + GD+++SVNGVS+
Sbjct: 108 VVELPKTDEGLGFNVMGGKEQNSP----IYISRIIPGGVAERHGGLKRGDQLLSVNGVSV 163
Query: 612 QNATLDQAVQALKGAPRGTVKV 633
+ ++AV+ LK A + +VK+
Sbjct: 164 EGEHHEKAVELLKAA-KDSVKL 184
Score = 58.8 bits (136), Expect = 6e-08
Identities = 30/79 (37%), Positives = 49/79 (62%), Gaps = 2/79 (2%)
Query: 12 VVELTNDGNGLGFNLVGGR--STGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFT 69
VVEL GLGFN++GG+ ++ + I ++PGGVA++ L+ GD +L V V++ G
Sbjct: 108 VVELPKTDEGLGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEH 167
Query: 70 SEQVAAVLRQAGPVVRLLV 88
E+ +L+ A V+L+V
Sbjct: 168 HEKAVELLKAAKDSVKLVV 186
Score = 52.8 bits (121), Expect = 4e-06
Identities = 32/84 (38%), Positives = 51/84 (60%), Gaps = 4/84 (4%)
Query: 199 VDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLAD 258
V+L K GLG V G KE+ S I++ II G AE+ G +K D+++ V+G+S+
Sbjct: 109 VELPKTDEGLGFNVMG---GKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEG 165
Query: 259 KSNPQSVEILRNTGISVHLVLERY 282
+ + ++VE+L+ SV LV+ RY
Sbjct: 166 EHHEKAVELLKAAKDSVKLVV-RY 188
Score = 49.2 bits (112), Expect = 5e-05
Identities = 32/84 (38%), Positives = 42/84 (50%), Gaps = 7/84 (8%)
Query: 386 VAEIKKL-EGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEY 444
V E+ K EGLG + V GG+E YI ++P G G L GD+LL VN
Sbjct: 108 VVELPKTDEGLGFN------VMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGV 161
Query: 445 RLHGLTHSEVVNILKQLPDRVRLV 468
+ G H + V +LK D V+LV
Sbjct: 162 SVEGEHHEKAVELLKAAKDSVKLV 185
>AF028826-1|AAB84251.1| 202|Homo sapiens Tax interaction protein 33
protein.
Length = 202
Score = 64.5 bits (150), Expect = 1e-09
Identities = 32/82 (39%), Positives = 56/82 (68%), Gaps = 5/82 (6%)
Query: 552 IVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSI 611
+V L K D+GLGF+++ ++ P I + ++PGGVAE++G + GD+++SVNGVS+
Sbjct: 77 VVELPKTDEGLGFNVMGGKEQNSP----IYISRIIPGGVAERHGGLKRGDQLLSVNGVSV 132
Query: 612 QNATLDQAVQALKGAPRGTVKV 633
+ ++AV+ LK A + +VK+
Sbjct: 133 EGEHHEKAVELLKAA-KDSVKL 153
Score = 58.8 bits (136), Expect = 6e-08
Identities = 30/79 (37%), Positives = 49/79 (62%), Gaps = 2/79 (2%)
Query: 12 VVELTNDGNGLGFNLVGGR--STGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFT 69
VVEL GLGFN++GG+ ++ + I ++PGGVA++ L+ GD +L V V++ G
Sbjct: 77 VVELPKTDEGLGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEH 136
Query: 70 SEQVAAVLRQAGPVVRLLV 88
E+ +L+ A V+L+V
Sbjct: 137 HEKAVELLKAAKDSVKLVV 155
Score = 52.8 bits (121), Expect = 4e-06
Identities = 32/84 (38%), Positives = 51/84 (60%), Gaps = 4/84 (4%)
Query: 199 VDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLAD 258
V+L K GLG V G KE+ S I++ II G AE+ G +K D+++ V+G+S+
Sbjct: 78 VELPKTDEGLGFNVMG---GKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEG 134
Query: 259 KSNPQSVEILRNTGISVHLVLERY 282
+ + ++VE+L+ SV LV+ RY
Sbjct: 135 EHHEKAVELLKAAKDSVKLVV-RY 157
Score = 49.2 bits (112), Expect = 5e-05
Identities = 32/84 (38%), Positives = 42/84 (50%), Gaps = 7/84 (8%)
Query: 386 VAEIKKL-EGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEY 444
V E+ K EGLG + V GG+E YI ++P G G L GD+LL VN
Sbjct: 77 VVELPKTDEGLGFN------VMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGV 130
Query: 445 RLHGLTHSEVVNILKQLPDRVRLV 468
+ G H + V +LK D V+LV
Sbjct: 131 SVEGEHHEKAVELLKAAKDSVKLV 154
>AK223156-1|BAD96876.1| 197|Homo sapiens lin-7 homolog C variant
protein.
Length = 197
Score = 63.7 bits (148), Expect = 2e-09
Identities = 31/82 (37%), Positives = 56/82 (68%), Gaps = 5/82 (6%)
Query: 552 IVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSI 611
+V L K ++GLGF+I+ ++ P I + ++PGG+A+++G + GD+++SVNGVS+
Sbjct: 93 VVELPKTEEGLGFNIMGGKEQNSP----IYISRIIPGGIADRHGGLKRGDQLLSVNGVSV 148
Query: 612 QNATLDQAVQALKGAPRGTVKV 633
+ ++AV+ LK A +G VK+
Sbjct: 149 EGEHHEKAVELLKAA-QGNVKL 169
Score = 59.3 bits (137), Expect = 4e-08
Identities = 30/79 (37%), Positives = 49/79 (62%), Gaps = 2/79 (2%)
Query: 12 VVELTNDGNGLGFNLVGGR--STGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFT 69
VVEL GLGFN++GG+ ++ + I ++PGG+AD+ L+ GD +L V V++ G
Sbjct: 93 VVELPKTEEGLGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEH 152
Query: 70 SEQVAAVLRQAGPVVRLLV 88
E+ +L+ A V+L+V
Sbjct: 153 HEKAVELLKAAQGNVKLVV 171
Score = 50.0 bits (114), Expect = 3e-05
Identities = 29/84 (34%), Positives = 51/84 (60%), Gaps = 4/84 (4%)
Query: 199 VDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLAD 258
V+L K GLG + G KE+ S I++ II G A++ G +K D+++ V+G+S+
Sbjct: 94 VELPKTEEGLGFNIMG---GKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEG 150
Query: 259 KSNPQSVEILRNTGISVHLVLERY 282
+ + ++VE+L+ +V LV+ RY
Sbjct: 151 EHHEKAVELLKAAQGNVKLVV-RY 173
Score = 46.4 bits (105), Expect = 3e-04
Identities = 30/84 (35%), Positives = 41/84 (48%), Gaps = 7/84 (8%)
Query: 386 VAEIKKLE-GLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEY 444
V E+ K E GLG + + GG+E YI ++P G G L GD+LL VN
Sbjct: 93 VVELPKTEEGLGFN------IMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGV 146
Query: 445 RLHGLTHSEVVNILKQLPDRVRLV 468
+ G H + V +LK V+LV
Sbjct: 147 SVEGEHHEKAVELLKAAQGNVKLV 170
>BC053907-1|AAH53907.1| 197|Homo sapiens lin-7 homolog C (C.
elegans) protein.
Length = 197
Score = 63.3 bits (147), Expect = 3e-09
Identities = 31/82 (37%), Positives = 56/82 (68%), Gaps = 5/82 (6%)
Query: 552 IVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSI 611
+V L K ++GLGF+I+ ++ P I + ++PGG+A+++G + GD+++SVNGVS+
Sbjct: 93 VVELPKTEEGLGFNIMGGKEQNSP----IYISRIIPGGIADRHGGLKRGDQLLSVNGVSV 148
Query: 612 QNATLDQAVQALKGAPRGTVKV 633
+ ++AV+ LK A +G VK+
Sbjct: 149 EGEHHEKAVELLKAA-QGKVKL 169
Score = 59.7 bits (138), Expect = 3e-08
Identities = 30/79 (37%), Positives = 49/79 (62%), Gaps = 2/79 (2%)
Query: 12 VVELTNDGNGLGFNLVGGR--STGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFT 69
VVEL GLGFN++GG+ ++ + I ++PGG+AD+ L+ GD +L V V++ G
Sbjct: 93 VVELPKTEEGLGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEH 152
Query: 70 SEQVAAVLRQAGPVVRLLV 88
E+ +L+ A V+L+V
Sbjct: 153 HEKAVELLKAAQGKVKLVV 171
Score = 49.6 bits (113), Expect = 3e-05
Identities = 29/84 (34%), Positives = 50/84 (59%), Gaps = 4/84 (4%)
Query: 199 VDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLAD 258
V+L K GLG + G KE+ S I++ II G A++ G +K D+++ V+G+S+
Sbjct: 94 VELPKTEEGLGFNIMG---GKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEG 150
Query: 259 KSNPQSVEILRNTGISVHLVLERY 282
+ + ++VE+L+ V LV+ RY
Sbjct: 151 EHHEKAVELLKAAQGKVKLVV-RY 173
Score = 47.2 bits (107), Expect = 2e-04
Identities = 30/84 (35%), Positives = 42/84 (50%), Gaps = 7/84 (8%)
Query: 386 VAEIKKLE-GLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEY 444
V E+ K E GLG + + GG+E YI ++P G G L GD+LL VN
Sbjct: 93 VVELPKTEEGLGFN------IMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGV 146
Query: 445 RLHGLTHSEVVNILKQLPDRVRLV 468
+ G H + V +LK +V+LV
Sbjct: 147 SVEGEHHEKAVELLKAAQGKVKLV 170
>AK002077-1|BAA92072.1| 197|Homo sapiens protein ( Homo sapiens
cDNA FLJ11215 fis, clone PLACE1008000, weakly similar to
CHANNEL ASSOCIATED PROTEIN OF SYNAPSE-110. ).
Length = 197
Score = 63.3 bits (147), Expect = 3e-09
Identities = 31/82 (37%), Positives = 56/82 (68%), Gaps = 5/82 (6%)
Query: 552 IVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSI 611
+V L K ++GLGF+I+ ++ P I + ++PGG+A+++G + GD+++SVNGVS+
Sbjct: 93 VVELPKTEEGLGFNIMGGKEQNSP----IYISRIIPGGIADRHGGLKRGDQLLSVNGVSV 148
Query: 612 QNATLDQAVQALKGAPRGTVKV 633
+ ++AV+ LK A +G VK+
Sbjct: 149 EGEHHEKAVELLKAA-QGKVKL 169
Score = 59.7 bits (138), Expect = 3e-08
Identities = 30/79 (37%), Positives = 49/79 (62%), Gaps = 2/79 (2%)
Query: 12 VVELTNDGNGLGFNLVGGR--STGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFT 69
VVEL GLGFN++GG+ ++ + I ++PGG+AD+ L+ GD +L V V++ G
Sbjct: 93 VVELPKTEEGLGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEH 152
Query: 70 SEQVAAVLRQAGPVVRLLV 88
E+ +L+ A V+L+V
Sbjct: 153 HEKAVELLKAAQGKVKLVV 171
Score = 49.6 bits (113), Expect = 3e-05
Identities = 29/84 (34%), Positives = 50/84 (59%), Gaps = 4/84 (4%)
Query: 199 VDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLAD 258
V+L K GLG + G KE+ S I++ II G A++ G +K D+++ V+G+S+
Sbjct: 94 VELPKTEEGLGFNIMG---GKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEG 150
Query: 259 KSNPQSVEILRNTGISVHLVLERY 282
+ + ++VE+L+ V LV+ RY
Sbjct: 151 EHHEKAVELLKAAQGKVKLVV-RY 173
Score = 47.2 bits (107), Expect = 2e-04
Identities = 30/84 (35%), Positives = 42/84 (50%), Gaps = 7/84 (8%)
Query: 386 VAEIKKLE-GLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEY 444
V E+ K E GLG + + GG+E YI ++P G G L GD+LL VN
Sbjct: 93 VVELPKTEEGLGFN------IMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGV 146
Query: 445 RLHGLTHSEVVNILKQLPDRVRLV 468
+ G H + V +LK +V+LV
Sbjct: 147 SVEGEHHEKAVELLKAAQGKVKLV 170
>U80754-1|AAC04844.1| 677|Homo sapiens membrane associated
guanylate kinase 1 protein.
Length = 677
Score = 62.9 bits (146), Expect = 3e-09
Identities = 69/258 (26%), Positives = 115/258 (44%), Gaps = 23/258 (8%)
Query: 405 VEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDR 464
V GG E I+S++ DGP L G + GD ++ VN+ + G TH++VV I + +P
Sbjct: 337 VVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIG 396
Query: 465 VRL---VCARNSIDSGP-RPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDT-SIN-- 517
+ +C + P P +L + + II + S T +N
Sbjct: 397 ASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVNGM 456
Query: 518 ----TSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPV 573
SS A + ++S + ++ S +A Q + V +VK G GF+I D
Sbjct: 457 KDARPSSPADVASNSSHGYPNDTVSLASSIAT-QPELITVHIVKGPMGFGFTIAD----- 510
Query: 574 DPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGT-VK 632
P G V+ +V + + + GD ++ VN ++Q T +Q V L P+G+ V
Sbjct: 511 SPGGGGQRVKQIVD---SPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVT 567
Query: 633 VGIAR-PLP-PQDSSKSK 648
+ + R LP P+ S KS+
Sbjct: 568 LLVQRGGLPVPKKSPKSQ 585
Score = 41.9 bits (94), Expect = 0.007
Identities = 63/269 (23%), Positives = 113/269 (42%), Gaps = 28/269 (10%)
Query: 195 EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGI 254
+ IH L K+ G G TV G E +E + +KS++ A GK++ D I+ V+
Sbjct: 320 KFIHTKLRKSSRGFGFTVVGGD-EPDEF--LQIKSLVLDGPAALDGKMETGDVIVSVNDT 376
Query: 255 SLADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHLQLAIFNEERXXXXXXXXXXLSWF 314
+ ++ Q V+I ++ I + LE RG L ++ L
Sbjct: 377 CVLGHTHAQVVKIFQSIPIGASVDLE-LCRG-----YPLPFDPDDPNTSLVTSVAILDKE 430
Query: 315 PVPSQLENSITEIEPEPESNTTIDSSVLEVGDLQEPTQEELDQRFDEILAVDKEDIVKKW 374
P+ + N E P S+++ V + D + + ++ D +
Sbjct: 431 PI---IVNG-QETYDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLA--- 483
Query: 375 KEEIGSDKEILVAEI-KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLN 433
I + E++ I K G G ++ D GG R ++ ++ D P +G L
Sbjct: 484 -SSIATQPELITVHIVKGPMGFGFTI---ADSPGGGGQR----VKQIV-DSP-RCRG-LK 532
Query: 434 AGDELLEVNEYRLHGLTHSEVVNILKQLP 462
GD ++EVN+ + LTH++VV++L + P
Sbjct: 533 EGDLIVEVNKKNVQALTHNQVVDMLVECP 561
Score = 41.5 bits (93), Expect = 0.009
Identities = 30/98 (30%), Positives = 52/98 (53%), Gaps = 9/98 (9%)
Query: 555 LVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNA 614
L K+ +G GF+++ +P + + ++SLV G A +G++ GD ++SVN +
Sbjct: 326 LRKSSRGFGFTVVGGDEPDE----FLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGH 381
Query: 615 TLDQAVQALKGAPRG-TVKVGIAR--PLP--PQDSSKS 647
T Q V+ + P G +V + + R PLP P D + S
Sbjct: 382 THAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTS 419
>AF401655-1|AAK94065.1| 1160|Homo sapiens MAGI-1A protein.
Length = 1160
Score = 62.9 bits (146), Expect = 3e-09
Identities = 100/458 (21%), Positives = 186/458 (40%), Gaps = 46/458 (10%)
Query: 195 EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGI 254
+ IH L K+ G G TV G E +E + +KS++ A GK++ D I+ V+
Sbjct: 469 KFIHTKLRKSSRGFGFTVVGGD-EPDEF--LQIKSLVLDGPAALDGKMETGDVIVSVNDT 525
Query: 255 SLADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHLQLAIFNEERXXXXXXXXXXLSWF 314
+ ++ Q V+I ++ I + LE RG L ++ L
Sbjct: 526 CVLGHTHAQVVKIFQSIPIGASVDLE-LCRG-----YPLPFDPDDPNTSLVTSVAILDKE 579
Query: 315 PVPSQLENSITEIEPEPESNTTIDSSVLEVGDLQEPTQEELDQRFDEILAVDKEDIVKKW 374
P+ + N E P S+++ V + D + + ++ D +
Sbjct: 580 PI---IVNG-QETYDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASS- 634
Query: 375 KEEIGSDKEILVAEIKKLE-GLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLN 433
I + E++ I K G G ++ D GG R ++ ++ D P +G L
Sbjct: 635 ---IATQPELITVHIVKGPMGFGFTI---ADSPGGGGQR----VKQIV-DSP-RCRG-LK 681
Query: 434 AGDELLEVNEYRLHGLTHSEVVNILKQLP--DRVRLVCARNSIDSGPRPVVNLASDREGF 491
GD ++EVN+ + LTH++VV++L + P V L+ R + + + +R+
Sbjct: 682 EGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDS 741
Query: 492 EARKIISGSLNNLTTLVKAQSDTSI------NTSSTATLTNHSEQSKKSRSLECVSGLAM 545
+ S S + T + + T+ S Q K +M
Sbjct: 742 QNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSM 801
Query: 546 WQSK-----EDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPG 600
++++ E + L + + G GF IL +P +P I + +VP G A+ +G + G
Sbjct: 802 YENRLPDYQEQDIFLWRKETGFGFRILGGNEPGEP----IYIGHIVPLGAADTDGRLRSG 857
Query: 601 DRVMSVNGVSIQNATLDQAVQAL-KGAPRGTVKVGIAR 637
D ++ V+G + + VQ + + A +G V + + R
Sbjct: 858 DELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRR 895
Score = 62.9 bits (146), Expect = 3e-09
Identities = 69/258 (26%), Positives = 115/258 (44%), Gaps = 23/258 (8%)
Query: 405 VEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDR 464
V GG E I+S++ DGP L G + GD ++ VN+ + G TH++VV I + +P
Sbjct: 486 VVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIG 545
Query: 465 VRL---VCARNSIDSGP-RPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDT-SIN-- 517
+ +C + P P +L + + II + S T +N
Sbjct: 546 ASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVNGM 605
Query: 518 ----TSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPV 573
SS A + ++S + ++ S +A Q + V +VK G GF+I D
Sbjct: 606 KDARPSSPADVASNSSHGYPNDTVSLASSIAT-QPELITVHIVKGPMGFGFTIAD----- 659
Query: 574 DPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGT-VK 632
P G V+ +V + + + GD ++ VN ++Q T +Q V L P+G+ V
Sbjct: 660 SPGGGGQRVKQIVD---SPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVT 716
Query: 633 VGIAR-PLP-PQDSSKSK 648
+ + R LP P+ S KS+
Sbjct: 717 LLVQRGGLPVPKKSPKSQ 734
Score = 50.0 bits (114), Expect = 3e-05
Identities = 26/94 (27%), Positives = 51/94 (54%), Gaps = 3/94 (3%)
Query: 188 PVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDR 247
P E + V+L + G G ++ G +E ++V + E AE+ GK++I D
Sbjct: 1046 PQATQEQDFYTVELERGAKGFGFSLRG---GREYNMDLYVLRLAEDGPAERCGKMRIGDE 1102
Query: 248 IIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
I+E++G + + + +++E+++N G V L L+R
Sbjct: 1103 ILEINGETTKNMKHSRAIELIKNGGRRVRLFLKR 1136
Score = 48.4 bits (110), Expect = 8e-05
Identities = 121/530 (22%), Positives = 206/530 (38%), Gaps = 82/530 (15%)
Query: 14 ELTNDGNGLGFNLVGGRSTG--VVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSE 71
+L G GF +VGG + IK ++ G A D ++++GD ++ V + G T
Sbjct: 474 KLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHA 533
Query: 72 QVAAVLRQA--GPVVRLLVAR----PADPATALRAPQPGTALVPTKILADPELLDRHLIE 125
QV + + G V L + R P DP P T+LV + + D E + + E
Sbjct: 534 QVVKIFQSIPIGASVDLELCRGYPLPFDP------DDPNTSLVTSVAILDKEPIIVNGQE 587
Query: 126 TGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQKIPDHPIVCDSVSPTITI 185
T YD +S G+ + + ++ V ++ P+ D+VS +I
Sbjct: 588 T-----YDSPASHSSKT--GKVNGMKDARPSSPADVASNSSHGYPN-----DTVSLASSI 635
Query: 186 TVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKIN 245
EL + I+ K G G T+A + G VK I++ +K
Sbjct: 636 ATQPELITVHIV-----KGPMGFGFTIA----DSPGGGGQRVKQIVDSPRCRG---LKEG 683
Query: 246 DRIIEVDGISLADKSNPQSVEILRNT--GISVHLVLERY-----LRGPKFEHLQLAIFNE 298
D I+EV+ ++ ++ Q V++L G V L+++R + PK + L+ +
Sbjct: 684 DLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERK--DS 741
Query: 299 ERXXXXXXXXXXLSWFPVPSQLENSITEIEP-EPESNTTIDSSVLEVGDLQEPTQEELDQ 357
+ PS + E P E ++ DSS + D + +
Sbjct: 742 QNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSM 801
Query: 358 RFDEILAVDKEDIVKKWKEEIGSDKEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYI 417
+ + ++DI W++E G IL GG E YI
Sbjct: 802 YENRLPDYQEQDIFL-WRKETGFGFRIL---------------------GGNEPGEPIYI 839
Query: 418 RSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDR--VRLVCARNSID 475
++P G G L +GDEL+ V+ + G +H VV +++Q + V L R +
Sbjct: 840 GHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVF 899
Query: 476 SGPR---PVVNLASDREG-------FEARKIISGSLNNLTTLVKAQSDTS 515
+ P+ V + AS E ++ GS N+L T+ TS
Sbjct: 900 AVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTS 949
Score = 48.0 bits (109), Expect = 1e-04
Identities = 33/105 (31%), Positives = 52/105 (49%), Gaps = 7/105 (6%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTG--VVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLR 66
Q + + L G GF ++GG G + I +++P G AD D RL+SGD ++ V +
Sbjct: 810 QEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVI 869
Query: 67 GFTSEQVAAVLRQAGPV--VRLLVARP---ADPATALRAPQPGTA 106
G + + V +++QA V L V R A P T P P ++
Sbjct: 870 GKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASS 914
Score = 45.6 bits (103), Expect = 6e-04
Identities = 27/92 (29%), Positives = 44/92 (47%), Gaps = 7/92 (7%)
Query: 381 DKEILVAEIKK-LEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELL 439
+++ E+++ +G G SL G G+E Y+ + DGP G + GDE+L
Sbjct: 1051 EQDFYTVELERGAKGFGFSLRG------GREYNMDLYVLRLAEDGPAERCGKMRIGDEIL 1104
Query: 440 EVNEYRLHGLTHSEVVNILKQLPDRVRLVCAR 471
E+N + HS + ++K RVRL R
Sbjct: 1105 EINGETTKNMKHSRAIELIKNGGRRVRLFLKR 1136
Score = 41.5 bits (93), Expect = 0.009
Identities = 30/98 (30%), Positives = 52/98 (53%), Gaps = 9/98 (9%)
Query: 555 LVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNA 614
L K+ +G GF+++ +P + + ++SLV G A +G++ GD ++SVN +
Sbjct: 475 LRKSSRGFGFTVVGGDEPDE----FLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGH 530
Query: 615 TLDQAVQALKGAPRG-TVKVGIAR--PLP--PQDSSKS 647
T Q V+ + P G +V + + R PLP P D + S
Sbjct: 531 THAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTS 568
Score = 41.5 bits (93), Expect = 0.009
Identities = 33/132 (25%), Positives = 63/132 (47%), Gaps = 9/132 (6%)
Query: 502 NNLTTLVKAQSDTSINTSSTATL-----TNHSEQSKKSRSLECVSGLAMWQSKEDIVMLV 556
+N T L A+ +I T+ T + T ++ + K+ E + A + V L
Sbjct: 1001 SNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELE 1060
Query: 557 KADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATL 616
+ +G GFS+ ++ N + V+R L G AE+ G++ GD ++ +NG + +N
Sbjct: 1061 RGAKGFGFSLRGGREY---NMDLYVLR-LAEDGPAERCGKMRIGDEILEINGETTKNMKH 1116
Query: 617 DQAVQALKGAPR 628
+A++ +K R
Sbjct: 1117 SRAIELIKNGGR 1128
Score = 39.5 bits (88), Expect = 0.037
Identities = 24/90 (26%), Positives = 43/90 (47%), Gaps = 4/90 (4%)
Query: 4 STEWAQVEVVELTNDGNGLGFNLVGGRSTGVVIKYVL---PGGVADKDRRLQSGDHVLQV 60
+T+ VEL G GF+L GGR + + YVL G A++ +++ GD +L++
Sbjct: 1048 ATQEQDFYTVELERGAKGFGFSLRGGREYNMDL-YVLRLAEDGPAERCGKMRIGDEILEI 1106
Query: 61 GSVNLRGFTSEQVAAVLRQAGPVVRLLVAR 90
+ + +++ G VRL + R
Sbjct: 1107 NGETTKNMKHSRAIELIKNGGRRVRLFLKR 1136
>AF401654-1|AAK94064.1| 1287|Homo sapiens MAGI-1B alpha beta
protein.
Length = 1287
Score = 62.9 bits (146), Expect = 3e-09
Identities = 69/258 (26%), Positives = 115/258 (44%), Gaps = 23/258 (8%)
Query: 405 VEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDR 464
V GG E I+S++ DGP L G + GD ++ VN+ + G TH++VV I + +P
Sbjct: 486 VVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIG 545
Query: 465 VRL---VCARNSIDSGP-RPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDT-SIN-- 517
+ +C + P P +L + + II + S T +N
Sbjct: 546 ASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVNGM 605
Query: 518 ----TSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPV 573
SS A + ++S + ++ S +A Q + V +VK G GF+I D
Sbjct: 606 KDARPSSPADVASNSSHGYPNDTVSLASSIAT-QPELITVHIVKGPMGFGFTIAD----- 659
Query: 574 DPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGT-VK 632
P G V+ +V + + + GD ++ VN ++Q T +Q V L P+G+ V
Sbjct: 660 SPGGGGQRVKQIVD---SPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVT 716
Query: 633 VGIAR-PLP-PQDSSKSK 648
+ + R LP P+ S KS+
Sbjct: 717 LLVQRGGLPVPKKSPKSQ 734
Score = 53.6 bits (123), Expect = 2e-06
Identities = 63/259 (24%), Positives = 109/259 (42%), Gaps = 19/259 (7%)
Query: 407 GGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDR-- 464
GG E YI ++P G G L +GDEL+ V+ + G +H VV +++Q +
Sbjct: 857 GGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGH 916
Query: 465 VRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTSSTATL 524
V L R + + P+ + S + + T +Q+ S+NT S+ +
Sbjct: 917 VNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQN--SLNTVSSGSG 974
Query: 525 TNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPN---GTVIV 581
+ S VS + D+ + ++G GF I+ + G V
Sbjct: 975 STSGIGSGGGGGSGVVSTVVQ---PYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACV 1031
Query: 582 -----VRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIA 636
+ ++ G A++ G++ GDR+++VNG SI N + V +K A TV +
Sbjct: 1032 AMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEA-GNTVTL--- 1087
Query: 637 RPLPPQDSSKSKGTINVNK 655
R +P +SS + N K
Sbjct: 1088 RIIPGDESSNATLLTNAEK 1106
Score = 50.0 bits (114), Expect = 3e-05
Identities = 26/94 (27%), Positives = 51/94 (54%), Gaps = 3/94 (3%)
Query: 188 PVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDR 247
P E + V+L + G G ++ G +E ++V + E AE+ GK++I D
Sbjct: 1141 PQATQEQDFYTVELERGAKGFGFSLRG---GREYNMDLYVLRLAEDGPAERCGKMRIGDE 1197
Query: 248 IIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
I+E++G + + + +++E+++N G V L L+R
Sbjct: 1198 ILEINGETTKNMKHSRAIELIKNGGRRVRLFLKR 1231
Score = 48.0 bits (109), Expect = 1e-04
Identities = 33/105 (31%), Positives = 52/105 (49%), Gaps = 7/105 (6%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTG--VVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLR 66
Q + + L G GF ++GG G + I +++P G AD D RL+SGD ++ V +
Sbjct: 838 QEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVI 897
Query: 67 GFTSEQVAAVLRQAGPV--VRLLVARP---ADPATALRAPQPGTA 106
G + + V +++QA V L V R A P T P P ++
Sbjct: 898 GKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASS 942
Score = 48.0 bits (109), Expect = 1e-04
Identities = 21/48 (43%), Positives = 34/48 (70%)
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHL 277
IIEGS A++ GK+K+ DRI+ V+G S+ +KS+ V +++ G +V L
Sbjct: 1040 IIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTL 1087
Score = 47.6 bits (108), Expect = 1e-04
Identities = 42/172 (24%), Positives = 78/172 (45%), Gaps = 10/172 (5%)
Query: 463 DRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGS-LNNLTTLVKAQSDTSINTSST 521
DR+ V + + +VNL + +II G +N T L A+ +I T+ T
Sbjct: 1056 DRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHT 1115
Query: 522 ATL-----TNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPN 576
+ T ++ + K+ E + A + V L + +G GFS+ ++ N
Sbjct: 1116 PSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREY---N 1172
Query: 577 GTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPR 628
+ V+R L G AE+ G++ GD ++ +NG + +N +A++ +K R
Sbjct: 1173 MDLYVLR-LAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGR 1223
Score = 45.6 bits (103), Expect = 6e-04
Identities = 27/92 (29%), Positives = 44/92 (47%), Gaps = 7/92 (7%)
Query: 381 DKEILVAEIKK-LEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELL 439
+++ E+++ +G G SL G G+E Y+ + DGP G + GDE+L
Sbjct: 1146 EQDFYTVELERGAKGFGFSLRG------GREYNMDLYVLRLAEDGPAERCGKMRIGDEIL 1199
Query: 440 EVNEYRLHGLTHSEVVNILKQLPDRVRLVCAR 471
E+N + HS + ++K RVRL R
Sbjct: 1200 EINGETTKNMKHSRAIELIKNGGRRVRLFLKR 1231
Score = 41.9 bits (94), Expect = 0.007
Identities = 63/269 (23%), Positives = 113/269 (42%), Gaps = 28/269 (10%)
Query: 195 EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGI 254
+ IH L K+ G G TV G E +E + +KS++ A GK++ D I+ V+
Sbjct: 469 KFIHTKLRKSSRGFGFTVVGGD-EPDEF--LQIKSLVLDGPAALDGKMETGDVIVSVNDT 525
Query: 255 SLADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHLQLAIFNEERXXXXXXXXXXLSWF 314
+ ++ Q V+I ++ I + LE RG L ++ L
Sbjct: 526 CVLGHTHAQVVKIFQSIPIGASVDLE-LCRG-----YPLPFDPDDPNTSLVTSVAILDKE 579
Query: 315 PVPSQLENSITEIEPEPESNTTIDSSVLEVGDLQEPTQEELDQRFDEILAVDKEDIVKKW 374
P+ + N E P S+++ V + D + + ++ D +
Sbjct: 580 PI---IVNG-QETYDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLA--- 632
Query: 375 KEEIGSDKEILVAEI-KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLN 433
I + E++ I K G G ++ D GG R ++ ++ D P +G L
Sbjct: 633 -SSIATQPELITVHIVKGPMGFGFTI---ADSPGGGGQR----VKQIV-DSP-RCRG-LK 681
Query: 434 AGDELLEVNEYRLHGLTHSEVVNILKQLP 462
GD ++EVN+ + LTH++VV++L + P
Sbjct: 682 EGDLIVEVNKKNVQALTHNQVVDMLVECP 710
Score = 41.9 bits (94), Expect = 0.007
Identities = 25/90 (27%), Positives = 46/90 (51%), Gaps = 5/90 (5%)
Query: 549 KEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNG 608
+E + L + + G GF IL +P +P I + +VP G A+ +G + GD ++ V+G
Sbjct: 838 QEQDIFLWRKETGFGFRILGGNEPGEP----IYIGHIVPLGAADTDGRLRSGDELICVDG 893
Query: 609 VSIQNATLDQAVQAL-KGAPRGTVKVGIAR 637
+ + VQ + + A +G V + + R
Sbjct: 894 TPVIGKSHQLVVQLMQQAAKQGHVNLTVRR 923
Score = 41.5 bits (93), Expect = 0.009
Identities = 30/98 (30%), Positives = 52/98 (53%), Gaps = 9/98 (9%)
Query: 555 LVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNA 614
L K+ +G GF+++ +P + + ++SLV G A +G++ GD ++SVN +
Sbjct: 475 LRKSSRGFGFTVVGGDEPDE----FLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGH 530
Query: 615 TLDQAVQALKGAPRG-TVKVGIAR--PLP--PQDSSKS 647
T Q V+ + P G +V + + R PLP P D + S
Sbjct: 531 THAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTS 568
Score = 39.5 bits (88), Expect = 0.037
Identities = 24/90 (26%), Positives = 43/90 (47%), Gaps = 4/90 (4%)
Query: 4 STEWAQVEVVELTNDGNGLGFNLVGGRSTGVVIKYVL---PGGVADKDRRLQSGDHVLQV 60
+T+ VEL G GF+L GGR + + YVL G A++ +++ GD +L++
Sbjct: 1143 ATQEQDFYTVELERGAKGFGFSLRGGREYNMDL-YVLRLAEDGPAERCGKMRIGDEILEI 1201
Query: 61 GSVNLRGFTSEQVAAVLRQAGPVVRLLVAR 90
+ + +++ G VRL + R
Sbjct: 1202 NGETTKNMKHSRAIELIKNGGRRVRLFLKR 1231
>AB010894-1|BAA32002.1| 1256|Homo sapiens BAI1-associated protein 1
protein.
Length = 1256
Score = 62.9 bits (146), Expect = 3e-09
Identities = 69/258 (26%), Positives = 115/258 (44%), Gaps = 23/258 (8%)
Query: 405 VEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDR 464
V GG E I+S++ DGP L G + GD ++ VN+ + G TH++VV I + +P
Sbjct: 486 VVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIG 545
Query: 465 VRL---VCARNSIDSGP-RPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDT-SIN-- 517
+ +C + P P +L + + II + S T +N
Sbjct: 546 ASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVNGM 605
Query: 518 ----TSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPV 573
SS A + ++S + ++ S +A Q + V +VK G GF+I D
Sbjct: 606 KDARPSSPADVASNSSHGYPNDTVSLASSIAT-QPELITVHIVKGPMGFGFTIAD----- 659
Query: 574 DPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGT-VK 632
P G V+ +V + + + GD ++ VN ++Q T +Q V L P+G+ V
Sbjct: 660 SPGGGGQRVKQIVD---SPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVT 716
Query: 633 VGIAR-PLP-PQDSSKSK 648
+ + R LP P+ S KS+
Sbjct: 717 LLVQRGGLPVPKKSPKSQ 734
Score = 52.8 bits (121), Expect = 4e-06
Identities = 63/260 (24%), Positives = 107/260 (41%), Gaps = 20/260 (7%)
Query: 407 GGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDR-- 464
GG E YI ++P G G L +GDEL+ V+ + G +H VV +++Q +
Sbjct: 857 GGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGH 916
Query: 465 VRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTSSTATL 524
V L R + + P+ + S + + T S S+NT S+ +
Sbjct: 917 VNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRT--PQGSQNSLNTVSSGSG 974
Query: 525 TNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPN----GTVI 580
+ S VS + D+ + ++G GF I+ + G
Sbjct: 975 STSGIGSGGGGGSGVVSTVV---QPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFAGNAC 1031
Query: 581 V-----VRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGI 635
V + ++ G A++ G++ GDR+++VNG SI N + V +K A TV +
Sbjct: 1032 VAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEA-GNTVTL-- 1088
Query: 636 ARPLPPQDSSKSKGTINVNK 655
R +P +SS + N K
Sbjct: 1089 -RIIPGDESSNATLLTNAEK 1107
Score = 50.0 bits (114), Expect = 3e-05
Identities = 26/94 (27%), Positives = 51/94 (54%), Gaps = 3/94 (3%)
Query: 188 PVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDR 247
P E + V+L + G G ++ G +E ++V + E AE+ GK++I D
Sbjct: 1142 PQATQEQDFYTVELERGAKGFGFSLRG---GREYNMDLYVLRLAEDGPAERCGKMRIGDE 1198
Query: 248 IIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
I+E++G + + + +++E+++N G V L L+R
Sbjct: 1199 ILEINGETTKNMKHSRAIELIKNGGRRVRLFLKR 1232
Score = 48.8 bits (111), Expect = 6e-05
Identities = 26/69 (37%), Positives = 40/69 (57%), Gaps = 3/69 (4%)
Query: 209 GITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEIL 268
G T AG C + IIEGS A++ GK+K+ DRI+ V+G S+ +KS+ V ++
Sbjct: 1023 GTTFAGNACVAMPHK---IGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLI 1079
Query: 269 RNTGISVHL 277
+ G +V L
Sbjct: 1080 KEAGNTVTL 1088
Score = 48.0 bits (109), Expect = 1e-04
Identities = 33/105 (31%), Positives = 52/105 (49%), Gaps = 7/105 (6%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTG--VVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLR 66
Q + + L G GF ++GG G + I +++P G AD D RL+SGD ++ V +
Sbjct: 838 QEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVI 897
Query: 67 GFTSEQVAAVLRQAGPV--VRLLVARP---ADPATALRAPQPGTA 106
G + + V +++QA V L V R A P T P P ++
Sbjct: 898 GKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASS 942
Score = 47.6 bits (108), Expect = 1e-04
Identities = 42/172 (24%), Positives = 78/172 (45%), Gaps = 10/172 (5%)
Query: 463 DRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGS-LNNLTTLVKAQSDTSINTSST 521
DR+ V + + +VNL + +II G +N T L A+ +I T+ T
Sbjct: 1057 DRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHT 1116
Query: 522 ATL-----TNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPN 576
+ T ++ + K+ E + A + V L + +G GFS+ ++ N
Sbjct: 1117 PSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREY---N 1173
Query: 577 GTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPR 628
+ V+R L G AE+ G++ GD ++ +NG + +N +A++ +K R
Sbjct: 1174 MDLYVLR-LAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGR 1224
Score = 45.6 bits (103), Expect = 6e-04
Identities = 27/92 (29%), Positives = 44/92 (47%), Gaps = 7/92 (7%)
Query: 381 DKEILVAEIKK-LEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELL 439
+++ E+++ +G G SL G G+E Y+ + DGP G + GDE+L
Sbjct: 1147 EQDFYTVELERGAKGFGFSLRG------GREYNMDLYVLRLAEDGPAERCGKMRIGDEIL 1200
Query: 440 EVNEYRLHGLTHSEVVNILKQLPDRVRLVCAR 471
E+N + HS + ++K RVRL R
Sbjct: 1201 EINGETTKNMKHSRAIELIKNGGRRVRLFLKR 1232
Score = 41.9 bits (94), Expect = 0.007
Identities = 63/269 (23%), Positives = 113/269 (42%), Gaps = 28/269 (10%)
Query: 195 EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGI 254
+ IH L K+ G G TV G E +E + +KS++ A GK++ D I+ V+
Sbjct: 469 KFIHTKLRKSSRGFGFTVVGGD-EPDEF--LQIKSLVLDGPAALDGKMETGDVIVSVNDT 525
Query: 255 SLADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHLQLAIFNEERXXXXXXXXXXLSWF 314
+ ++ Q V+I ++ I + LE RG L ++ L
Sbjct: 526 CVLGHTHAQVVKIFQSIPIGASVDLE-LCRG-----YPLPFDPDDPNTSLVTSVAILDKE 579
Query: 315 PVPSQLENSITEIEPEPESNTTIDSSVLEVGDLQEPTQEELDQRFDEILAVDKEDIVKKW 374
P+ + N E P S+++ V + D + + ++ D +
Sbjct: 580 PI---IVNG-QETYDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLA--- 632
Query: 375 KEEIGSDKEILVAEI-KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLN 433
I + E++ I K G G ++ D GG R ++ ++ D P +G L
Sbjct: 633 -SSIATQPELITVHIVKGPMGFGFTI---ADSPGGGGQR----VKQIV-DSP-RCRG-LK 681
Query: 434 AGDELLEVNEYRLHGLTHSEVVNILKQLP 462
GD ++EVN+ + LTH++VV++L + P
Sbjct: 682 EGDLIVEVNKKNVQALTHNQVVDMLVECP 710
Score = 41.5 bits (93), Expect = 0.009
Identities = 30/98 (30%), Positives = 52/98 (53%), Gaps = 9/98 (9%)
Query: 555 LVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNA 614
L K+ +G GF+++ +P + + ++SLV G A +G++ GD ++SVN +
Sbjct: 475 LRKSSRGFGFTVVGGDEPDE----FLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGH 530
Query: 615 TLDQAVQALKGAPRG-TVKVGIAR--PLP--PQDSSKS 647
T Q V+ + P G +V + + R PLP P D + S
Sbjct: 531 THAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTS 568
Score = 39.5 bits (88), Expect = 0.037
Identities = 24/90 (26%), Positives = 43/90 (47%), Gaps = 4/90 (4%)
Query: 4 STEWAQVEVVELTNDGNGLGFNLVGGRSTGVVIKYVL---PGGVADKDRRLQSGDHVLQV 60
+T+ VEL G GF+L GGR + + YVL G A++ +++ GD +L++
Sbjct: 1144 ATQEQDFYTVELERGAKGFGFSLRGGREYNMDL-YVLRLAEDGPAERCGKMRIGDEILEI 1202
Query: 61 GSVNLRGFTSEQVAAVLRQAGPVVRLLVAR 90
+ + +++ G VRL + R
Sbjct: 1203 NGETTKNMKHSRAIELIKNGGRRVRLFLKR 1232
>CR407680-1|CAG28608.1| 233|Homo sapiens LIN7A protein.
Length = 233
Score = 62.5 bits (145), Expect = 5e-09
Identities = 31/82 (37%), Positives = 55/82 (67%), Gaps = 5/82 (6%)
Query: 552 IVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSI 611
+V L K D+GLGF+++ ++ P I + ++PGGVAE++G + GD+++ VNGVS+
Sbjct: 108 VVELPKTDEGLGFNVMGGKEQNSP----IYISRIIPGGVAERHGGLKRGDQLLPVNGVSV 163
Query: 612 QNATLDQAVQALKGAPRGTVKV 633
+ ++AV+ LK A + +VK+
Sbjct: 164 EGEHHEKAVELLKAA-KDSVKL 184
Score = 58.4 bits (135), Expect = 7e-08
Identities = 30/79 (37%), Positives = 49/79 (62%), Gaps = 2/79 (2%)
Query: 12 VVELTNDGNGLGFNLVGGR--STGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFT 69
VVEL GLGFN++GG+ ++ + I ++PGGVA++ L+ GD +L V V++ G
Sbjct: 108 VVELPKTDEGLGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLPVNGVSVEGEH 167
Query: 70 SEQVAAVLRQAGPVVRLLV 88
E+ +L+ A V+L+V
Sbjct: 168 HEKAVELLKAAKDSVKLVV 186
Score = 52.4 bits (120), Expect = 5e-06
Identities = 32/84 (38%), Positives = 51/84 (60%), Gaps = 4/84 (4%)
Query: 199 VDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLAD 258
V+L K GLG V G KE+ S I++ II G AE+ G +K D+++ V+G+S+
Sbjct: 109 VELPKTDEGLGFNVMG---GKEQNSPIYISRIIPGGVAERHGGLKRGDQLLPVNGVSVEG 165
Query: 259 KSNPQSVEILRNTGISVHLVLERY 282
+ + ++VE+L+ SV LV+ RY
Sbjct: 166 EHHEKAVELLKAAKDSVKLVV-RY 188
Score = 48.8 bits (111), Expect = 6e-05
Identities = 32/84 (38%), Positives = 42/84 (50%), Gaps = 7/84 (8%)
Query: 386 VAEIKKL-EGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEY 444
V E+ K EGLG + V GG+E YI ++P G G L GD+LL VN
Sbjct: 108 VVELPKTDEGLGFN------VMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLPVNGV 161
Query: 445 RLHGLTHSEVVNILKQLPDRVRLV 468
+ G H + V +LK D V+LV
Sbjct: 162 SVEGEHHEKAVELLKAAKDSVKLV 185
>AK098775-1|BAC05409.1| 517|Homo sapiens protein ( Homo sapiens
cDNA FLJ25909 fis, clone CBR04667, highly similar to
Homo sapiens multi PDZ domain protein MUPP1 (MUPP1)
mRNA. ).
Length = 517
Score = 62.1 bits (144), Expect = 6e-09
Identities = 36/85 (42%), Positives = 50/85 (58%), Gaps = 2/85 (2%)
Query: 19 GNGLGFNLVGGRS-TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAVL 77
G GLG ++VG R+ TGV + ++ GG+AD D RL GD +L V ++R T E VAA+L
Sbjct: 180 GKGLGLSIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALL 239
Query: 78 RQAGPVVRLLVAR-PADPATALRAP 101
+ + V L V R A P + R P
Sbjct: 240 KCSLGTVTLEVGRIKAGPFHSERRP 264
Score = 57.6 bits (133), Expect = 1e-07
Identities = 32/85 (37%), Positives = 47/85 (55%), Gaps = 3/85 (3%)
Query: 13 VELTNDGNGLGFNLVGGRST---GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFT 69
+E++ GLG ++VGG T ++I V G A KD RL +GD +L+V ++LR T
Sbjct: 77 IEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKAT 136
Query: 70 SEQVAAVLRQAGPVVRLLVARPADP 94
++ VLRQ VRL + R P
Sbjct: 137 HDEAINVLRQTPQRVRLTLYRDEAP 161
Score = 54.8 bits (126), Expect = 9e-07
Identities = 68/263 (25%), Positives = 113/263 (42%), Gaps = 34/263 (12%)
Query: 374 WKEEIGSDKEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLN 433
+KEE D + + K +GLG+S+ G + G ++ ++ G G L
Sbjct: 162 YKEEEVCDTLTIELQKKPGKGLGLSIVGKRNDTGV-------FVSDIVKGGIADADGRLM 214
Query: 434 AGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEA 493
GD++L VN + T V +LK V L R I +GP S+R ++
Sbjct: 215 QGDQILMVNGEDVRNATQEAVAALLKCSLGTVTLEVGR--IKAGP-----FHSERRPSQS 267
Query: 494 RKIISGSLNNLTTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIV 553
++ GSL++ T S ++T + SKK+ + GL + K+
Sbjct: 268 SQVSEGSLSSFT----------FPLSGSSTSESLESSSKKNALASEIQGLRTVEMKKG-- 315
Query: 554 MLVKADQGLGFSILDYQDPVDPNGTV-IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
LG SI P G V I + + P GVA + ++ GDR++++ G S +
Sbjct: 316 ----PTDSLGISIAGGVG--SPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTE 369
Query: 613 NATLDQAVQALKGAPRGTVKVGI 635
T QAV LK A G++++ +
Sbjct: 370 GMTHTQAVNLLKNA-SGSIEMQV 391
Score = 53.2 bits (122), Expect = 3e-06
Identities = 32/79 (40%), Positives = 42/79 (53%), Gaps = 5/79 (6%)
Query: 394 GLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSE 453
GLG+S+ G D G + I V +G G L AGD++LEVN L TH E
Sbjct: 85 GLGLSIVGGSDTLLGAII-----IHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDE 139
Query: 454 VVNILKQLPDRVRLVCARN 472
+N+L+Q P RVRL R+
Sbjct: 140 AINVLRQTPQRVRLTLYRD 158
Score = 53.2 bits (122), Expect = 3e-06
Identities = 30/81 (37%), Positives = 47/81 (58%), Gaps = 6/81 (7%)
Query: 557 KADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATL 616
K +GLG SI+ + N T + V +V GG+A+ +G + GD+++ VNG ++NAT
Sbjct: 178 KPGKGLGLSIVGKR-----NDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNAT- 231
Query: 617 DQAVQALKGAPRGTVKVGIAR 637
+AV AL GTV + + R
Sbjct: 232 QEAVAALLKCSLGTVTLEVGR 252
Score = 52.4 bits (120), Expect = 5e-06
Identities = 28/85 (32%), Positives = 46/85 (54%), Gaps = 5/85 (5%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDHVLQVGSV 63
Q + + L +GLGF++VGG + + +K V G A +D RL+ GD ++ V
Sbjct: 431 QCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQ 490
Query: 64 NLRGFTSEQVAAVLRQAGPVVRLLV 88
+L G T E+ A+L++ V L+V
Sbjct: 491 SLEGVTHEEAVAILKRTKGTVTLMV 515
Score = 52.0 bits (119), Expect = 6e-06
Identities = 43/170 (25%), Positives = 82/170 (48%), Gaps = 17/170 (10%)
Query: 463 DRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTSSTA 522
DR+ +C ++ VNL + G ++++G +++ + Q + + ++ S
Sbjct: 358 DRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGG--DVSVVTGHQQEPASSSLSFT 415
Query: 523 TLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTV-IV 581
LT+ S +C S + L + GLGFSI+ P+G + I
Sbjct: 416 GLTSSSIFQDDLGPPQCKS-----------ITLERGPDGLGFSIVGGYG--SPHGDLPIY 462
Query: 582 VRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTV 631
V+++ G A ++G + GD++++VNG S++ T ++AV LK +GTV
Sbjct: 463 VKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILK-RTKGTV 511
Score = 48.8 bits (111), Expect = 6e-05
Identities = 28/104 (26%), Positives = 53/104 (50%), Gaps = 4/104 (3%)
Query: 550 EDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGV 609
E + + K GLG SI+ D + I++ + G A K+G + GD+++ VNG+
Sbjct: 74 ETTIEISKGRTGLGLSIVGGSDTLLG---AIIIHEVYEEGAACKDGRLWAGDQILEVNGI 130
Query: 610 SIQNATLDQAVQALKGAPRGTVKVGIARPLPPQDSSKSKGTINV 653
++ AT D+A+ L+ P+ V++ + R P + T+ +
Sbjct: 131 DLRKATHDEAINVLRQTPQ-RVRLTLYRDEAPYKEEEVCDTLTI 173
Score = 47.6 bits (108), Expect = 1e-04
Identities = 30/106 (28%), Positives = 54/106 (50%), Gaps = 4/106 (3%)
Query: 178 SVSPTITITVPVELPEIEIIH--VDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSS 235
S +P I + P P I ++++K GLG+++ G L I + + E +
Sbjct: 54 SSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGG--SDTLLGAIIIHEVYEEGA 111
Query: 236 AEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
A + G++ D+I+EV+GI L ++ +++ +LR T V L L R
Sbjct: 112 ACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYR 157
Score = 46.4 bits (105), Expect = 3e-04
Identities = 35/138 (25%), Positives = 69/138 (50%), Gaps = 3/138 (2%)
Query: 143 INGQNGETETSIVAAA-VSVIGDNPQKIPDHPIVCDSVSPTITITVPVELPEIEIIHVDL 201
+ +G E +VA VSV+ + Q+ + ++ + + P+ + I ++
Sbjct: 380 LKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKSITLER 439
Query: 202 NKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSN 261
+ G I V GY +L I+VK++ +A + G++K D+II V+G SL ++
Sbjct: 440 GPDGLGFSI-VGGYGSPHGDLP-IYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTH 497
Query: 262 PQSVEILRNTGISVHLVL 279
++V IL+ T +V L++
Sbjct: 498 EEAVAILKRTKGTVTLMV 515
Score = 43.6 bits (98), Expect = 0.002
Identities = 27/76 (35%), Positives = 38/76 (50%), Gaps = 3/76 (3%)
Query: 393 EGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHS 452
+GLG S+ G G P Y+++V G G L GD+++ VN L G+TH
Sbjct: 442 DGLGFSIVGGYGSPHGD--LPI-YVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHE 498
Query: 453 EVVNILKQLPDRVRLV 468
E V ILK+ V L+
Sbjct: 499 EAVAILKRTKGTVTLM 514
Score = 39.1 bits (87), Expect = 0.049
Identities = 21/70 (30%), Positives = 38/70 (54%)
Query: 208 LGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEI 267
LGI++AG V IF+ + A Q+ K+++ DRI+ + G S ++ Q+V +
Sbjct: 320 LGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNL 379
Query: 268 LRNTGISVHL 277
L+N S+ +
Sbjct: 380 LKNASGSIEM 389
Score = 38.7 bits (86), Expect = 0.064
Identities = 22/80 (27%), Positives = 43/80 (53%), Gaps = 4/80 (5%)
Query: 207 GLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVE 266
GLG+++ G K +G+FV I++G A+ G++ D+I+ V+G + + +
Sbjct: 182 GLGLSIVG----KRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAA 237
Query: 267 ILRNTGISVHLVLERYLRGP 286
+L+ + +V L + R GP
Sbjct: 238 LLKCSLGTVTLEVGRIKAGP 257
Score = 33.9 bits (74), Expect = 1.8
Identities = 23/97 (23%), Positives = 45/97 (46%), Gaps = 6/97 (6%)
Query: 3 LSTEWAQVEVVELTNDG-NGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDH 56
L++E + VE+ + LG ++ GG + + I + P GVA + ++L+ GD
Sbjct: 300 LASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDR 359
Query: 57 VLQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVARPAD 93
++ + + G T Q +L+ A + + V D
Sbjct: 360 IVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGD 396
>AJ001319-1|CAA04680.1| 453|Homo sapiens multi PDZ domain protein 1
protein.
Length = 453
Score = 62.1 bits (144), Expect = 6e-09
Identities = 36/85 (42%), Positives = 50/85 (58%), Gaps = 2/85 (2%)
Query: 19 GNGLGFNLVGGRS-TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAVL 77
G GLG ++VG R+ TGV + ++ GG+AD D RL GD +L V ++R T E VAA+L
Sbjct: 116 GKGLGLSIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALL 175
Query: 78 RQAGPVVRLLVAR-PADPATALRAP 101
+ + V L V R A P + R P
Sbjct: 176 KCSLGTVTLEVGRIKAGPFHSERRP 200
Score = 57.6 bits (133), Expect = 1e-07
Identities = 32/85 (37%), Positives = 47/85 (55%), Gaps = 3/85 (3%)
Query: 13 VELTNDGNGLGFNLVGGRST---GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFT 69
+E++ GLG ++VGG T ++I V G A KD RL +GD +L+V ++LR T
Sbjct: 13 IEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKAT 72
Query: 70 SEQVAAVLRQAGPVVRLLVARPADP 94
++ VLRQ VRL + R P
Sbjct: 73 HDEAINVLRQTPQRVRLTLYRDEAP 97
Score = 54.8 bits (126), Expect = 9e-07
Identities = 68/263 (25%), Positives = 113/263 (42%), Gaps = 34/263 (12%)
Query: 374 WKEEIGSDKEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLN 433
+KEE D + + K +GLG+S+ G + G ++ ++ G G L
Sbjct: 98 YKEEEVCDTLTIELQKKPGKGLGLSIVGKRNDTGV-------FVSDIVKGGIADADGRLM 150
Query: 434 AGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEA 493
GD++L VN + T V +LK V L R I +GP S+R ++
Sbjct: 151 QGDQILMVNGEDVRNATQEAVAALLKCSLGTVTLEVGR--IKAGP-----FHSERRPSQS 203
Query: 494 RKIISGSLNNLTTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIV 553
++ GSL++ T S ++T + SKK+ + GL + K+
Sbjct: 204 SQVSEGSLSSFT----------FPLSGSSTSESLESSSKKNALASEIQGLRTVEMKKG-- 251
Query: 554 MLVKADQGLGFSILDYQDPVDPNGTV-IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
LG SI P G V I + + P GVA + ++ GDR++++ G S +
Sbjct: 252 ----PTDSLGISIAGGVG--SPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTE 305
Query: 613 NATLDQAVQALKGAPRGTVKVGI 635
T QAV LK A G++++ +
Sbjct: 306 GMTHTQAVNLLKNA-SGSIEMQV 327
Score = 53.2 bits (122), Expect = 3e-06
Identities = 32/79 (40%), Positives = 42/79 (53%), Gaps = 5/79 (6%)
Query: 394 GLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSE 453
GLG+S+ G D G + I V +G G L AGD++LEVN L TH E
Sbjct: 21 GLGLSIVGGSDTLLGAII-----IHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDE 75
Query: 454 VVNILKQLPDRVRLVCARN 472
+N+L+Q P RVRL R+
Sbjct: 76 AINVLRQTPQRVRLTLYRD 94
Score = 53.2 bits (122), Expect = 3e-06
Identities = 30/81 (37%), Positives = 47/81 (58%), Gaps = 6/81 (7%)
Query: 557 KADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATL 616
K +GLG SI+ + N T + V +V GG+A+ +G + GD+++ VNG ++NAT
Sbjct: 114 KPGKGLGLSIVGKR-----NDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNAT- 167
Query: 617 DQAVQALKGAPRGTVKVGIAR 637
+AV AL GTV + + R
Sbjct: 168 QEAVAALLKCSLGTVTLEVGR 188
Score = 52.4 bits (120), Expect = 5e-06
Identities = 28/85 (32%), Positives = 46/85 (54%), Gaps = 5/85 (5%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDHVLQVGSV 63
Q + + L +GLGF++VGG + + +K V G A +D RL+ GD ++ V
Sbjct: 367 QCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQ 426
Query: 64 NLRGFTSEQVAAVLRQAGPVVRLLV 88
+L G T E+ A+L++ V L+V
Sbjct: 427 SLEGVTHEEAVAILKRTKGTVTLMV 451
Score = 52.0 bits (119), Expect = 6e-06
Identities = 43/170 (25%), Positives = 82/170 (48%), Gaps = 17/170 (10%)
Query: 463 DRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTSSTA 522
DR+ +C ++ VNL + G ++++G +++ + Q + + ++ S
Sbjct: 294 DRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGG--DVSVVTGHQQEPASSSLSFT 351
Query: 523 TLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTV-IV 581
LT+ S +C S + L + GLGFSI+ P+G + I
Sbjct: 352 GLTSSSIFQDDLGPPQCKS-----------ITLERGPDGLGFSIVGGYG--SPHGDLPIY 398
Query: 582 VRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTV 631
V+++ G A ++G + GD++++VNG S++ T ++AV LK +GTV
Sbjct: 399 VKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILK-RTKGTV 447
Score = 48.8 bits (111), Expect = 6e-05
Identities = 28/104 (26%), Positives = 53/104 (50%), Gaps = 4/104 (3%)
Query: 550 EDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGV 609
E + + K GLG SI+ D + I++ + G A K+G + GD+++ VNG+
Sbjct: 10 ETTIEISKGRTGLGLSIVGGSDTLLG---AIIIHEVYEEGAACKDGRLWAGDQILEVNGI 66
Query: 610 SIQNATLDQAVQALKGAPRGTVKVGIARPLPPQDSSKSKGTINV 653
++ AT D+A+ L+ P+ V++ + R P + T+ +
Sbjct: 67 DLRKATHDEAINVLRQTPQ-RVRLTLYRDEAPYKEEEVCDTLTI 109
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 52/96 (54%), Gaps = 4/96 (4%)
Query: 186 TVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKIN 245
T P+ +P E ++++K GLG+++ G L I + + E +A + G++
Sbjct: 2 TCPI-IPGCETT-IEISKGRTGLGLSIVGG--SDTLLGAIIIHEVYEEGAACKDGRLWAG 57
Query: 246 DRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
D+I+EV+GI L ++ +++ +LR T V L L R
Sbjct: 58 DQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYR 93
Score = 46.4 bits (105), Expect = 3e-04
Identities = 35/138 (25%), Positives = 69/138 (50%), Gaps = 3/138 (2%)
Query: 143 INGQNGETETSIVAAA-VSVIGDNPQKIPDHPIVCDSVSPTITITVPVELPEIEIIHVDL 201
+ +G E +VA VSV+ + Q+ + ++ + + P+ + I ++
Sbjct: 316 LKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKSITLER 375
Query: 202 NKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSN 261
+ G I V GY +L I+VK++ +A + G++K D+II V+G SL ++
Sbjct: 376 GPDGLGFSI-VGGYGSPHGDLP-IYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTH 433
Query: 262 PQSVEILRNTGISVHLVL 279
++V IL+ T +V L++
Sbjct: 434 EEAVAILKRTKGTVTLMV 451
Score = 43.6 bits (98), Expect = 0.002
Identities = 27/76 (35%), Positives = 38/76 (50%), Gaps = 3/76 (3%)
Query: 393 EGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHS 452
+GLG S+ G G P Y+++V G G L GD+++ VN L G+TH
Sbjct: 378 DGLGFSIVGGYGSPHGD--LPI-YVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHE 434
Query: 453 EVVNILKQLPDRVRLV 468
E V ILK+ V L+
Sbjct: 435 EAVAILKRTKGTVTLM 450
Score = 39.1 bits (87), Expect = 0.049
Identities = 21/70 (30%), Positives = 38/70 (54%)
Query: 208 LGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEI 267
LGI++AG V IF+ + A Q+ K+++ DRI+ + G S ++ Q+V +
Sbjct: 256 LGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNL 315
Query: 268 LRNTGISVHL 277
L+N S+ +
Sbjct: 316 LKNASGSIEM 325
Score = 38.7 bits (86), Expect = 0.064
Identities = 22/80 (27%), Positives = 43/80 (53%), Gaps = 4/80 (5%)
Query: 207 GLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVE 266
GLG+++ G K +G+FV I++G A+ G++ D+I+ V+G + + +
Sbjct: 118 GLGLSIVG----KRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAA 173
Query: 267 ILRNTGISVHLVLERYLRGP 286
+L+ + +V L + R GP
Sbjct: 174 LLKCSLGTVTLEVGRIKAGP 193
Score = 33.9 bits (74), Expect = 1.8
Identities = 23/97 (23%), Positives = 45/97 (46%), Gaps = 6/97 (6%)
Query: 3 LSTEWAQVEVVELTNDG-NGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDH 56
L++E + VE+ + LG ++ GG + + I + P GVA + ++L+ GD
Sbjct: 236 LASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDR 295
Query: 57 VLQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVARPAD 93
++ + + G T Q +L+ A + + V D
Sbjct: 296 IVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGD 332
>BC016162-1|AAH16162.1| 314|Homo sapiens PPP1R9B protein protein.
Length = 314
Score = 61.7 bits (143), Expect = 8e-09
Identities = 34/90 (37%), Positives = 52/90 (57%), Gaps = 3/90 (3%)
Query: 207 GLGITVAGYVCEKE---ELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQ 263
GLGI++ G + E GIFVK++ EG +A + G+I++ND ++EVDG SL +
Sbjct: 2 GLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTSLVGVTQSF 61
Query: 264 SVEILRNTGISVHLVLERYLRGPKFEHLQL 293
+ +LRNT V ++ R G + E QL
Sbjct: 62 AASVLRNTKGRVRFMIGRERPGEQSEVAQL 91
Score = 45.2 bits (102), Expect = 7e-04
Identities = 25/72 (34%), Positives = 38/72 (52%), Gaps = 1/72 (1%)
Query: 19 GNGLGFNLVGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAVLR 78
G G G ++ G G+ +K V GG A +D R+Q D +++V +L G T A+VLR
Sbjct: 9 GMGAGADM-GLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTSLVGVTQSFAASVLR 67
Query: 79 QAGPVVRLLVAR 90
VR ++ R
Sbjct: 68 NTKGRVRFMIGR 79
Score = 39.5 bits (88), Expect = 0.037
Identities = 26/87 (29%), Positives = 41/87 (47%), Gaps = 3/87 (3%)
Query: 560 QGLGFSILDYQDPVDPN--GTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLD 617
+GLG SI+ D I V+++ GG A ++G I D ++ V+G S+ T
Sbjct: 1 EGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTSLVGVTQS 60
Query: 618 QAVQALKGAPRGTVKVGIARPLPPQDS 644
A L+ +G V+ I R P + S
Sbjct: 61 FAASVLRNT-KGRVRFMIGRERPGEQS 86
Score = 36.7 bits (81), Expect = 0.26
Identities = 25/80 (31%), Positives = 40/80 (50%), Gaps = 2/80 (2%)
Query: 393 EGLGISLEGT-VDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTH 451
EGLGIS+ G + G E + ++++V G G + D L+EV+ L G+T
Sbjct: 1 EGLGISIIGMGAGADMGLE-KLGIFVKTVTEGGAAHRDGRIQVNDLLVEVDGTSLVGVTQ 59
Query: 452 SEVVNILKQLPDRVRLVCAR 471
S ++L+ RVR + R
Sbjct: 60 SFAASVLRNTKGRVRFMIGR 79
>BC130409-1|AAI30410.1| 1125|Homo sapiens membrane associated
guanylate kinase, WW and PDZ domain containing 3
protein.
Length = 1125
Score = 59.7 bits (138), Expect = 3e-08
Identities = 63/247 (25%), Positives = 103/247 (41%), Gaps = 20/247 (8%)
Query: 412 RPHHY--IRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP--DRVRL 467
RP + +++VL DGP G + GD ++++N + G TH++VV + + +P V L
Sbjct: 429 RPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNL 488
Query: 468 VCARN--SIDSGPRPVVNLASDREGFEARKIISG-SLNNLTTLVKAQSDTSINTSSTATL 524
R D PVV++ + + + G + N N S TL
Sbjct: 489 TLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQDFKPGAMVLEQNGKSGHTL 548
Query: 525 TNHSEQSKKSRSLECVSGLAMWQSKEDIVM--LVKADQGLGFSILDYQDPVDPNGTVIVV 582
T S + VS + S+ ++V L+K +G GF+I D P +I+
Sbjct: 549 TGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAIAD--SPTGQKVKMILD 606
Query: 583 RSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGT-VKVGIARPLPP 641
G + GD + + ++QN T Q V+ LK P G V + I R PP
Sbjct: 607 SQWCQG--------LQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPP 658
Query: 642 QDSSKSK 648
+ +K
Sbjct: 659 SPTKTAK 665
Score = 58.0 bits (134), Expect = 1e-07
Identities = 49/214 (22%), Positives = 92/214 (42%), Gaps = 8/214 (3%)
Query: 415 HYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSI 474
H I V+ P G L GD + VN + L+H +V ++K V L
Sbjct: 880 HKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEE 939
Query: 475 DSGPRPVVNLASDREGFEARKIISGSLNNL---TTLVKAQSDTSINTSSTATLTNHSEQS 531
GP N A + R + N++ + ++ + ++TS + ++H +
Sbjct: 940 HHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLA 999
Query: 532 KKSRSLECVSGLAMWQSKEDI-VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGV 590
+ ++ V G Q+ V L + +G GFS+ + + N + ++R L G
Sbjct: 1000 QPDTAVISVVGSRHNQNLGCYPVELERGPRGFGFSL---RGGKEYNMGLFILR-LAEDGP 1055
Query: 591 AEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
A K+G I GD+++ +NG Q T +A++ ++
Sbjct: 1056 AIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQ 1089
Score = 53.2 bits (122), Expect = 3e-06
Identities = 62/227 (27%), Positives = 103/227 (45%), Gaps = 26/227 (11%)
Query: 432 LNAGDELLEVNEYRLHGLTHSEVVNILKQLP--DRVRLVCARNSIDSGPRPVVNLASDRE 489
L GD + E+ + LTH +VV +LKQ P V L+ R S P + +D+
Sbjct: 613 LQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPS-PTKTAKMKTDK- 670
Query: 490 GFEARKIISGSLNNLTTLVKAQSD--TSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQ 547
K +GSL + + SI S + L + SE KS++L
Sbjct: 671 -----KENAGSLEAINEPIPQPMPFPPSIIRSGSPKL-DPSEVYLKSKTLYEDKPP---N 721
Query: 548 SKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVN 607
+K+ V L K + G GF +L P D + I + +++P G AEK+G + D +M ++
Sbjct: 722 TKDLDVFLRKQESGFGFRVLGGDGP-DQS---IYIGAIIPLGAAEKDGRLRAADELMCID 777
Query: 608 GVSIQNATLDQAVQALKGAPR-GTVKVGIARPL------PPQDSSKS 647
G+ ++ + Q + + A R G V + + R + P DSS++
Sbjct: 778 GIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQA 824
Score = 47.6 bits (108), Expect = 1e-04
Identities = 25/80 (31%), Positives = 42/80 (52%)
Query: 547 QSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSV 606
Q D+V+ K ++G GF IL ++ P + ++ G A++ G++ GD + +V
Sbjct: 847 QEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAV 906
Query: 607 NGVSIQNATLDQAVQALKGA 626
NG SI + D VQ +K A
Sbjct: 907 NGQSIVELSHDNIVQLIKDA 926
Score = 47.2 bits (107), Expect = 2e-04
Identities = 59/275 (21%), Positives = 112/275 (40%), Gaps = 32/275 (11%)
Query: 11 EVVELTNDGNGLGFNLVGGRST---GVV---IKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
+VV + G GF ++ ++ GV+ I V+ G AD+ +L+ GDH+ V +
Sbjct: 851 DVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQS 910
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVPTKILADPELLDRHLI 124
+ + + + +++ AG V L V + P GT P L R
Sbjct: 911 IVELSHDNIVQLIKDAGVTVTLTVIAEEEH----HGPPSGT----NSARQSPALQHR--- 959
Query: 125 ETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQKIPDHPIVCDSVSPTIT 184
+ Q +++ I G E I V DH + + I+
Sbjct: 960 --------PMGQSQANH-IPGDRSALEGEI---GKDVSTSYRHSWSDHKHLAQPDTAVIS 1007
Query: 185 ITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKI 244
+ + V+L + G G ++ G KE G+F+ + E A + G+I +
Sbjct: 1008 VVGSRHNQNLGCYPVELERGPRGFGFSLRG---GKEYNMGLFILRLAEDGPAIKDGRIHV 1064
Query: 245 NDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
D+I+E++G ++ +++E+++ G V L+L
Sbjct: 1065 GDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLL 1099
Score = 45.2 bits (102), Expect = 7e-04
Identities = 21/59 (35%), Positives = 38/59 (64%), Gaps = 2/59 (3%)
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHL--VLERYLRGP 286
+IEGS A++ GK+K+ D I V+G S+ + S+ V+++++ G++V L + E GP
Sbjct: 885 VIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGP 943
Score = 42.7 bits (96), Expect = 0.004
Identities = 29/81 (35%), Positives = 42/81 (51%), Gaps = 3/81 (3%)
Query: 13 VELTNDGNGLGFNLVGGR--STGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTS 70
VEL G GF+L GG+ + G+ I + G A KD R+ GD ++++ +G T
Sbjct: 1022 VELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITH 1081
Query: 71 EQVAAVLRQAGPVVRLLVARP 91
+ A L QAG LL+ RP
Sbjct: 1082 TR-AIELIQAGGNKVLLLLRP 1101
Score = 40.3 bits (90), Expect = 0.021
Identities = 17/64 (26%), Positives = 36/64 (56%)
Query: 405 VEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDR 464
+ GG+E +I + DGP G ++ GD+++E+N G+TH+ + +++ ++
Sbjct: 1035 LRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNK 1094
Query: 465 VRLV 468
V L+
Sbjct: 1095 VLLL 1098
Score = 39.5 bits (88), Expect = 0.037
Identities = 20/70 (28%), Positives = 39/70 (55%), Gaps = 2/70 (2%)
Query: 13 VELTNDGNGLGFNLVGGRST--GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTS 70
V L +G GF ++GG + I ++P G A+KD RL++ D ++ + + ++G +
Sbjct: 727 VFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSH 786
Query: 71 EQVAAVLRQA 80
+QV ++ A
Sbjct: 787 KQVLDLMTTA 796
Score = 31.9 bits (69), Expect = 7.4
Identities = 25/89 (28%), Positives = 40/89 (44%), Gaps = 6/89 (6%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGF 68
++ + L G GF + TG +K +L + LQ GD + ++ N++
Sbjct: 575 ELVTIPLIKGPKGFGF-AIADSPTGQKVKMILDSQWC---QGLQKGDIIKEIYHQNVQNL 630
Query: 69 TSEQVAAVLRQ--AGPVVRLLVARPADPA 95
T QV VL+Q G V LL+ R P+
Sbjct: 631 THLQVVEVLKQFPVGADVPLLILRGGPPS 659
Score = 31.5 bits (68), Expect = 9.7
Identities = 16/54 (29%), Positives = 29/54 (53%)
Query: 405 VEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNIL 458
V GG YI +++P G G L A DEL+ ++ + G +H +V++++
Sbjct: 740 VLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLM 793
>AL390759-4|CAH74143.1| 1125|Homo sapiens membrane associated
guanylate kinase, WW and PDZ domain containing 3
protein.
Length = 1125
Score = 59.7 bits (138), Expect = 3e-08
Identities = 63/247 (25%), Positives = 103/247 (41%), Gaps = 20/247 (8%)
Query: 412 RPHHY--IRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP--DRVRL 467
RP + +++VL DGP G + GD ++++N + G TH++VV + + +P V L
Sbjct: 429 RPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNL 488
Query: 468 VCARN--SIDSGPRPVVNLASDREGFEARKIISG-SLNNLTTLVKAQSDTSINTSSTATL 524
R D PVV++ + + + G + N N S TL
Sbjct: 489 TLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQDFKPGAMVLEQNGKSGHTL 548
Query: 525 TNHSEQSKKSRSLECVSGLAMWQSKEDIVM--LVKADQGLGFSILDYQDPVDPNGTVIVV 582
T S + VS + S+ ++V L+K +G GF+I D P +I+
Sbjct: 549 TGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAIAD--SPTGQKVKMILD 606
Query: 583 RSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGT-VKVGIARPLPP 641
G + GD + + ++QN T Q V+ LK P G V + I R PP
Sbjct: 607 SQWCQG--------LQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPP 658
Query: 642 QDSSKSK 648
+ +K
Sbjct: 659 SPTKTAK 665
Score = 58.0 bits (134), Expect = 1e-07
Identities = 49/214 (22%), Positives = 92/214 (42%), Gaps = 8/214 (3%)
Query: 415 HYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSI 474
H I V+ P G L GD + VN + L+H +V ++K V L
Sbjct: 880 HKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEE 939
Query: 475 DSGPRPVVNLASDREGFEARKIISGSLNNL---TTLVKAQSDTSINTSSTATLTNHSEQS 531
GP N A + R + N++ + ++ + ++TS + ++H +
Sbjct: 940 HHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLA 999
Query: 532 KKSRSLECVSGLAMWQSKEDI-VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGV 590
+ ++ V G Q+ V L + +G GFS+ + + N + ++R L G
Sbjct: 1000 QPDTAVISVVGSRHNQNLGCYPVELERGPRGFGFSL---RGGKEYNMGLFILR-LAEDGP 1055
Query: 591 AEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
A K+G I GD+++ +NG Q T +A++ ++
Sbjct: 1056 AIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQ 1089
Score = 53.2 bits (122), Expect = 3e-06
Identities = 62/227 (27%), Positives = 103/227 (45%), Gaps = 26/227 (11%)
Query: 432 LNAGDELLEVNEYRLHGLTHSEVVNILKQLP--DRVRLVCARNSIDSGPRPVVNLASDRE 489
L GD + E+ + LTH +VV +LKQ P V L+ R S P + +D+
Sbjct: 613 LQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPS-PTKTAKMKTDK- 670
Query: 490 GFEARKIISGSLNNLTTLVKAQSD--TSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQ 547
K +GSL + + SI S + L + SE KS++L
Sbjct: 671 -----KENAGSLEAINEPIPQPMPFPPSIIRSGSPKL-DPSEVYLKSKTLYEDKPP---N 721
Query: 548 SKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVN 607
+K+ V L K + G GF +L P D + I + +++P G AEK+G + D +M ++
Sbjct: 722 TKDLDVFLRKQESGFGFRVLGGDGP-DQS---IYIGAIIPLGAAEKDGRLRAADELMCID 777
Query: 608 GVSIQNATLDQAVQALKGAPR-GTVKVGIARPL------PPQDSSKS 647
G+ ++ + Q + + A R G V + + R + P DSS++
Sbjct: 778 GIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQA 824
Score = 47.6 bits (108), Expect = 1e-04
Identities = 25/80 (31%), Positives = 42/80 (52%)
Query: 547 QSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSV 606
Q D+V+ K ++G GF IL ++ P + ++ G A++ G++ GD + +V
Sbjct: 847 QEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAV 906
Query: 607 NGVSIQNATLDQAVQALKGA 626
NG SI + D VQ +K A
Sbjct: 907 NGQSIVELSHDNIVQLIKDA 926
Score = 47.2 bits (107), Expect = 2e-04
Identities = 59/275 (21%), Positives = 112/275 (40%), Gaps = 32/275 (11%)
Query: 11 EVVELTNDGNGLGFNLVGGRST---GVV---IKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
+VV + G GF ++ ++ GV+ I V+ G AD+ +L+ GDH+ V +
Sbjct: 851 DVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQS 910
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVPTKILADPELLDRHLI 124
+ + + + +++ AG V L V + P GT P L R
Sbjct: 911 IVELSHDNIVQLIKDAGVTVTLTVIAEEEH----HGPPSGT----NSARQSPALQHR--- 959
Query: 125 ETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQKIPDHPIVCDSVSPTIT 184
+ Q +++ I G E I V DH + + I+
Sbjct: 960 --------PMGQSQANH-IPGDRSALEGEI---GKDVSTSYRHSWSDHKHLAQPDTAVIS 1007
Query: 185 ITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKI 244
+ + V+L + G G ++ G KE G+F+ + E A + G+I +
Sbjct: 1008 VVGSRHNQNLGCYPVELERGPRGFGFSLRG---GKEYNMGLFILRLAEDGPAIKDGRIHV 1064
Query: 245 NDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
D+I+E++G ++ +++E+++ G V L+L
Sbjct: 1065 GDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLL 1099
Score = 45.2 bits (102), Expect = 7e-04
Identities = 21/59 (35%), Positives = 38/59 (64%), Gaps = 2/59 (3%)
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHL--VLERYLRGP 286
+IEGS A++ GK+K+ D I V+G S+ + S+ V+++++ G++V L + E GP
Sbjct: 885 VIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGP 943
Score = 42.7 bits (96), Expect = 0.004
Identities = 29/81 (35%), Positives = 42/81 (51%), Gaps = 3/81 (3%)
Query: 13 VELTNDGNGLGFNLVGGR--STGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTS 70
VEL G GF+L GG+ + G+ I + G A KD R+ GD ++++ +G T
Sbjct: 1022 VELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITH 1081
Query: 71 EQVAAVLRQAGPVVRLLVARP 91
+ A L QAG LL+ RP
Sbjct: 1082 TR-AIELIQAGGNKVLLLLRP 1101
Score = 40.3 bits (90), Expect = 0.021
Identities = 17/64 (26%), Positives = 36/64 (56%)
Query: 405 VEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDR 464
+ GG+E +I + DGP G ++ GD+++E+N G+TH+ + +++ ++
Sbjct: 1035 LRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNK 1094
Query: 465 VRLV 468
V L+
Sbjct: 1095 VLLL 1098
Score = 39.5 bits (88), Expect = 0.037
Identities = 20/70 (28%), Positives = 39/70 (55%), Gaps = 2/70 (2%)
Query: 13 VELTNDGNGLGFNLVGGRST--GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTS 70
V L +G GF ++GG + I ++P G A+KD RL++ D ++ + + ++G +
Sbjct: 727 VFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSH 786
Query: 71 EQVAAVLRQA 80
+QV ++ A
Sbjct: 787 KQVLDLMTTA 796
Score = 31.9 bits (69), Expect = 7.4
Identities = 25/89 (28%), Positives = 40/89 (44%), Gaps = 6/89 (6%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGF 68
++ + L G GF + TG +K +L + LQ GD + ++ N++
Sbjct: 575 ELVTIPLIKGPKGFGF-AIADSPTGQKVKMILDSQWC---QGLQKGDIIKEIYHQNVQNL 630
Query: 69 TSEQVAAVLRQ--AGPVVRLLVARPADPA 95
T QV VL+Q G V LL+ R P+
Sbjct: 631 THLQVVEVLKQFPVGADVPLLILRGGPPS 659
Score = 31.5 bits (68), Expect = 9.7
Identities = 16/54 (29%), Positives = 29/54 (53%)
Query: 405 VEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNIL 458
V GG YI +++P G G L A DEL+ ++ + G +H +V++++
Sbjct: 740 VLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLM 793
>AL390759-3|CAH74142.1| 1150|Homo sapiens membrane associated
guanylate kinase, WW and PDZ domain containing 3
protein.
Length = 1150
Score = 59.7 bits (138), Expect = 3e-08
Identities = 63/247 (25%), Positives = 103/247 (41%), Gaps = 20/247 (8%)
Query: 412 RPHHY--IRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP--DRVRL 467
RP + +++VL DGP G + GD ++++N + G TH++VV + + +P V L
Sbjct: 454 RPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNL 513
Query: 468 VCARN--SIDSGPRPVVNLASDREGFEARKIISG-SLNNLTTLVKAQSDTSINTSSTATL 524
R D PVV++ + + + G + N N S TL
Sbjct: 514 TLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQDFKPGAMVLEQNGKSGHTL 573
Query: 525 TNHSEQSKKSRSLECVSGLAMWQSKEDIVM--LVKADQGLGFSILDYQDPVDPNGTVIVV 582
T S + VS + S+ ++V L+K +G GF+I D P +I+
Sbjct: 574 TGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAIAD--SPTGQKVKMILD 631
Query: 583 RSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGT-VKVGIARPLPP 641
G + GD + + ++QN T Q V+ LK P G V + I R PP
Sbjct: 632 SQWCQG--------LQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPP 683
Query: 642 QDSSKSK 648
+ +K
Sbjct: 684 SPTKTAK 690
Score = 58.0 bits (134), Expect = 1e-07
Identities = 49/214 (22%), Positives = 92/214 (42%), Gaps = 8/214 (3%)
Query: 415 HYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSI 474
H I V+ P G L GD + VN + L+H +V ++K V L
Sbjct: 905 HKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEE 964
Query: 475 DSGPRPVVNLASDREGFEARKIISGSLNNL---TTLVKAQSDTSINTSSTATLTNHSEQS 531
GP N A + R + N++ + ++ + ++TS + ++H +
Sbjct: 965 HHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLA 1024
Query: 532 KKSRSLECVSGLAMWQSKEDI-VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGV 590
+ ++ V G Q+ V L + +G GFS+ + + N + ++R L G
Sbjct: 1025 QPDTAVISVVGSRHNQNLGCYPVELERGPRGFGFSL---RGGKEYNMGLFILR-LAEDGP 1080
Query: 591 AEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
A K+G I GD+++ +NG Q T +A++ ++
Sbjct: 1081 AIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQ 1114
Score = 53.2 bits (122), Expect = 3e-06
Identities = 62/227 (27%), Positives = 103/227 (45%), Gaps = 26/227 (11%)
Query: 432 LNAGDELLEVNEYRLHGLTHSEVVNILKQLP--DRVRLVCARNSIDSGPRPVVNLASDRE 489
L GD + E+ + LTH +VV +LKQ P V L+ R S P + +D+
Sbjct: 638 LQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPS-PTKTAKMKTDK- 695
Query: 490 GFEARKIISGSLNNLTTLVKAQSD--TSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQ 547
K +GSL + + SI S + L + SE KS++L
Sbjct: 696 -----KENAGSLEAINEPIPQPMPFPPSIIRSGSPKL-DPSEVYLKSKTLYEDKPP---N 746
Query: 548 SKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVN 607
+K+ V L K + G GF +L P D + I + +++P G AEK+G + D +M ++
Sbjct: 747 TKDLDVFLRKQESGFGFRVLGGDGP-DQS---IYIGAIIPLGAAEKDGRLRAADELMCID 802
Query: 608 GVSIQNATLDQAVQALKGAPR-GTVKVGIARPL------PPQDSSKS 647
G+ ++ + Q + + A R G V + + R + P DSS++
Sbjct: 803 GIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQA 849
Score = 47.6 bits (108), Expect = 1e-04
Identities = 25/80 (31%), Positives = 42/80 (52%)
Query: 547 QSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSV 606
Q D+V+ K ++G GF IL ++ P + ++ G A++ G++ GD + +V
Sbjct: 872 QEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAV 931
Query: 607 NGVSIQNATLDQAVQALKGA 626
NG SI + D VQ +K A
Sbjct: 932 NGQSIVELSHDNIVQLIKDA 951
Score = 47.2 bits (107), Expect = 2e-04
Identities = 59/275 (21%), Positives = 112/275 (40%), Gaps = 32/275 (11%)
Query: 11 EVVELTNDGNGLGFNLVGGRST---GVV---IKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
+VV + G GF ++ ++ GV+ I V+ G AD+ +L+ GDH+ V +
Sbjct: 876 DVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQS 935
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVPTKILADPELLDRHLI 124
+ + + + +++ AG V L V + P GT P L R
Sbjct: 936 IVELSHDNIVQLIKDAGVTVTLTVIAEEEH----HGPPSGT----NSARQSPALQHR--- 984
Query: 125 ETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQKIPDHPIVCDSVSPTIT 184
+ Q +++ I G E I V DH + + I+
Sbjct: 985 --------PMGQSQANH-IPGDRSALEGEI---GKDVSTSYRHSWSDHKHLAQPDTAVIS 1032
Query: 185 ITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKI 244
+ + V+L + G G ++ G KE G+F+ + E A + G+I +
Sbjct: 1033 VVGSRHNQNLGCYPVELERGPRGFGFSLRG---GKEYNMGLFILRLAEDGPAIKDGRIHV 1089
Query: 245 NDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
D+I+E++G ++ +++E+++ G V L+L
Sbjct: 1090 GDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLL 1124
Score = 45.2 bits (102), Expect = 7e-04
Identities = 21/59 (35%), Positives = 38/59 (64%), Gaps = 2/59 (3%)
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHL--VLERYLRGP 286
+IEGS A++ GK+K+ D I V+G S+ + S+ V+++++ G++V L + E GP
Sbjct: 910 VIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGP 968
Score = 42.7 bits (96), Expect = 0.004
Identities = 29/81 (35%), Positives = 42/81 (51%), Gaps = 3/81 (3%)
Query: 13 VELTNDGNGLGFNLVGGR--STGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTS 70
VEL G GF+L GG+ + G+ I + G A KD R+ GD ++++ +G T
Sbjct: 1047 VELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITH 1106
Query: 71 EQVAAVLRQAGPVVRLLVARP 91
+ A L QAG LL+ RP
Sbjct: 1107 TR-AIELIQAGGNKVLLLLRP 1126
Score = 40.3 bits (90), Expect = 0.021
Identities = 17/64 (26%), Positives = 36/64 (56%)
Query: 405 VEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDR 464
+ GG+E +I + DGP G ++ GD+++E+N G+TH+ + +++ ++
Sbjct: 1060 LRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNK 1119
Query: 465 VRLV 468
V L+
Sbjct: 1120 VLLL 1123
Score = 39.5 bits (88), Expect = 0.037
Identities = 20/70 (28%), Positives = 39/70 (55%), Gaps = 2/70 (2%)
Query: 13 VELTNDGNGLGFNLVGGRST--GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTS 70
V L +G GF ++GG + I ++P G A+KD RL++ D ++ + + ++G +
Sbjct: 752 VFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSH 811
Query: 71 EQVAAVLRQA 80
+QV ++ A
Sbjct: 812 KQVLDLMTTA 821
Score = 31.9 bits (69), Expect = 7.4
Identities = 25/89 (28%), Positives = 40/89 (44%), Gaps = 6/89 (6%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGF 68
++ + L G GF + TG +K +L + LQ GD + ++ N++
Sbjct: 600 ELVTIPLIKGPKGFGF-AIADSPTGQKVKMILDSQWC---QGLQKGDIIKEIYHQNVQNL 655
Query: 69 TSEQVAAVLRQ--AGPVVRLLVARPADPA 95
T QV VL+Q G V LL+ R P+
Sbjct: 656 THLQVVEVLKQFPVGADVPLLILRGGPPS 684
Score = 31.5 bits (68), Expect = 9.7
Identities = 16/54 (29%), Positives = 29/54 (53%)
Query: 405 VEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNIL 458
V GG YI +++P G G L A DEL+ ++ + G +H +V++++
Sbjct: 765 VLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLM 818
>AL390759-2|CAH74141.1| 1481|Homo sapiens membrane associated
guanylate kinase, WW and PDZ domain containing 3
protein.
Length = 1481
Score = 59.7 bits (138), Expect = 3e-08
Identities = 63/247 (25%), Positives = 103/247 (41%), Gaps = 20/247 (8%)
Query: 412 RPHHY--IRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP--DRVRL 467
RP + +++VL DGP G + GD ++++N + G TH++VV + + +P V L
Sbjct: 429 RPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNL 488
Query: 468 VCARN--SIDSGPRPVVNLASDREGFEARKIISG-SLNNLTTLVKAQSDTSINTSSTATL 524
R D PVV++ + + + G + N N S TL
Sbjct: 489 TLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQDFKPGAMVLEQNGKSGHTL 548
Query: 525 TNHSEQSKKSRSLECVSGLAMWQSKEDIVM--LVKADQGLGFSILDYQDPVDPNGTVIVV 582
T S + VS + S+ ++V L+K +G GF+I D P +I+
Sbjct: 549 TGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAIAD--SPTGQKVKMILD 606
Query: 583 RSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGT-VKVGIARPLPP 641
G + GD + + ++QN T Q V+ LK P G V + I R PP
Sbjct: 607 SQWCQG--------LQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPP 658
Query: 642 QDSSKSK 648
+ +K
Sbjct: 659 SPTKTAK 665
Score = 58.0 bits (134), Expect = 1e-07
Identities = 49/214 (22%), Positives = 92/214 (42%), Gaps = 8/214 (3%)
Query: 415 HYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSI 474
H I V+ P G L GD + VN + L+H +V ++K V L
Sbjct: 880 HKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEE 939
Query: 475 DSGPRPVVNLASDREGFEARKIISGSLNNL---TTLVKAQSDTSINTSSTATLTNHSEQS 531
GP N A + R + N++ + ++ + ++TS + ++H +
Sbjct: 940 HHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLA 999
Query: 532 KKSRSLECVSGLAMWQSKEDI-VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGV 590
+ ++ V G Q+ V L + +G GFS+ + + N + ++R L G
Sbjct: 1000 QPDTAVISVVGSRHNQNLGCYPVELERGPRGFGFSL---RGGKEYNMGLFILR-LAEDGP 1055
Query: 591 AEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
A K+G I GD+++ +NG Q T +A++ ++
Sbjct: 1056 AIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQ 1089
Score = 53.2 bits (122), Expect = 3e-06
Identities = 62/227 (27%), Positives = 103/227 (45%), Gaps = 26/227 (11%)
Query: 432 LNAGDELLEVNEYRLHGLTHSEVVNILKQLP--DRVRLVCARNSIDSGPRPVVNLASDRE 489
L GD + E+ + LTH +VV +LKQ P V L+ R S P + +D+
Sbjct: 613 LQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPS-PTKTAKMKTDK- 670
Query: 490 GFEARKIISGSLNNLTTLVKAQSD--TSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQ 547
K +GSL + + SI S + L + SE KS++L
Sbjct: 671 -----KENAGSLEAINEPIPQPMPFPPSIIRSGSPKL-DPSEVYLKSKTLYEDKPP---N 721
Query: 548 SKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVN 607
+K+ V L K + G GF +L P D + I + +++P G AEK+G + D +M ++
Sbjct: 722 TKDLDVFLRKQESGFGFRVLGGDGP-DQS---IYIGAIIPLGAAEKDGRLRAADELMCID 777
Query: 608 GVSIQNATLDQAVQALKGAPR-GTVKVGIARPL------PPQDSSKS 647
G+ ++ + Q + + A R G V + + R + P DSS++
Sbjct: 778 GIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQA 824
Score = 47.6 bits (108), Expect = 1e-04
Identities = 25/80 (31%), Positives = 42/80 (52%)
Query: 547 QSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSV 606
Q D+V+ K ++G GF IL ++ P + ++ G A++ G++ GD + +V
Sbjct: 847 QEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAV 906
Query: 607 NGVSIQNATLDQAVQALKGA 626
NG SI + D VQ +K A
Sbjct: 907 NGQSIVELSHDNIVQLIKDA 926
Score = 47.2 bits (107), Expect = 2e-04
Identities = 59/275 (21%), Positives = 112/275 (40%), Gaps = 32/275 (11%)
Query: 11 EVVELTNDGNGLGFNLVGGRST---GVV---IKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
+VV + G GF ++ ++ GV+ I V+ G AD+ +L+ GDH+ V +
Sbjct: 851 DVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQS 910
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVPTKILADPELLDRHLI 124
+ + + + +++ AG V L V + P GT P L R
Sbjct: 911 IVELSHDNIVQLIKDAGVTVTLTVIAEEEH----HGPPSGT----NSARQSPALQHR--- 959
Query: 125 ETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQKIPDHPIVCDSVSPTIT 184
+ Q +++ I G E I V DH + + I+
Sbjct: 960 --------PMGQSQANH-IPGDRSALEGEI---GKDVSTSYRHSWSDHKHLAQPDTAVIS 1007
Query: 185 ITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKI 244
+ + V+L + G G ++ G KE G+F+ + E A + G+I +
Sbjct: 1008 VVGSRHNQNLGCYPVELERGPRGFGFSLRG---GKEYNMGLFILRLAEDGPAIKDGRIHV 1064
Query: 245 NDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
D+I+E++G ++ +++E+++ G V L+L
Sbjct: 1065 GDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLL 1099
Score = 45.2 bits (102), Expect = 7e-04
Identities = 21/59 (35%), Positives = 38/59 (64%), Gaps = 2/59 (3%)
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHL--VLERYLRGP 286
+IEGS A++ GK+K+ D I V+G S+ + S+ V+++++ G++V L + E GP
Sbjct: 885 VIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGP 943
Score = 42.7 bits (96), Expect = 0.004
Identities = 29/81 (35%), Positives = 42/81 (51%), Gaps = 3/81 (3%)
Query: 13 VELTNDGNGLGFNLVGGR--STGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTS 70
VEL G GF+L GG+ + G+ I + G A KD R+ GD ++++ +G T
Sbjct: 1022 VELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITH 1081
Query: 71 EQVAAVLRQAGPVVRLLVARP 91
+ A L QAG LL+ RP
Sbjct: 1082 TR-AIELIQAGGNKVLLLLRP 1101
Score = 40.3 bits (90), Expect = 0.021
Identities = 17/64 (26%), Positives = 36/64 (56%)
Query: 405 VEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDR 464
+ GG+E +I + DGP G ++ GD+++E+N G+TH+ + +++ ++
Sbjct: 1035 LRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNK 1094
Query: 465 VRLV 468
V L+
Sbjct: 1095 VLLL 1098
Score = 39.5 bits (88), Expect = 0.037
Identities = 20/70 (28%), Positives = 39/70 (55%), Gaps = 2/70 (2%)
Query: 13 VELTNDGNGLGFNLVGGRST--GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTS 70
V L +G GF ++GG + I ++P G A+KD RL++ D ++ + + ++G +
Sbjct: 727 VFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSH 786
Query: 71 EQVAAVLRQA 80
+QV ++ A
Sbjct: 787 KQVLDLMTTA 796
Score = 31.9 bits (69), Expect = 7.4
Identities = 25/89 (28%), Positives = 40/89 (44%), Gaps = 6/89 (6%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGF 68
++ + L G GF + TG +K +L + LQ GD + ++ N++
Sbjct: 575 ELVTIPLIKGPKGFGF-AIADSPTGQKVKMILDSQWC---QGLQKGDIIKEIYHQNVQNL 630
Query: 69 TSEQVAAVLRQ--AGPVVRLLVARPADPA 95
T QV VL+Q G V LL+ R P+
Sbjct: 631 THLQVVEVLKQFPVGADVPLLILRGGPPS 659
Score = 31.5 bits (68), Expect = 9.7
Identities = 16/54 (29%), Positives = 29/54 (53%)
Query: 405 VEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNIL 458
V GG YI +++P G G L A DEL+ ++ + G +H +V++++
Sbjct: 740 VLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLM 793
>AL389921-3|CAH71508.1| 1150|Homo sapiens membrane associated
guanylate kinase, WW and PDZ domain containing 3
protein.
Length = 1150
Score = 59.7 bits (138), Expect = 3e-08
Identities = 63/247 (25%), Positives = 103/247 (41%), Gaps = 20/247 (8%)
Query: 412 RPHHY--IRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP--DRVRL 467
RP + +++VL DGP G + GD ++++N + G TH++VV + + +P V L
Sbjct: 454 RPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNL 513
Query: 468 VCARN--SIDSGPRPVVNLASDREGFEARKIISG-SLNNLTTLVKAQSDTSINTSSTATL 524
R D PVV++ + + + G + N N S TL
Sbjct: 514 TLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQDFKPGAMVLEQNGKSGHTL 573
Query: 525 TNHSEQSKKSRSLECVSGLAMWQSKEDIVM--LVKADQGLGFSILDYQDPVDPNGTVIVV 582
T S + VS + S+ ++V L+K +G GF+I D P +I+
Sbjct: 574 TGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAIAD--SPTGQKVKMILD 631
Query: 583 RSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGT-VKVGIARPLPP 641
G + GD + + ++QN T Q V+ LK P G V + I R PP
Sbjct: 632 SQWCQG--------LQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPP 683
Query: 642 QDSSKSK 648
+ +K
Sbjct: 684 SPTKTAK 690
Score = 58.0 bits (134), Expect = 1e-07
Identities = 49/214 (22%), Positives = 92/214 (42%), Gaps = 8/214 (3%)
Query: 415 HYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSI 474
H I V+ P G L GD + VN + L+H +V ++K V L
Sbjct: 905 HKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEE 964
Query: 475 DSGPRPVVNLASDREGFEARKIISGSLNNL---TTLVKAQSDTSINTSSTATLTNHSEQS 531
GP N A + R + N++ + ++ + ++TS + ++H +
Sbjct: 965 HHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLA 1024
Query: 532 KKSRSLECVSGLAMWQSKEDI-VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGV 590
+ ++ V G Q+ V L + +G GFS+ + + N + ++R L G
Sbjct: 1025 QPDTAVISVVGSRHNQNLGCYPVELERGPRGFGFSL---RGGKEYNMGLFILR-LAEDGP 1080
Query: 591 AEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
A K+G I GD+++ +NG Q T +A++ ++
Sbjct: 1081 AIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQ 1114
Score = 53.2 bits (122), Expect = 3e-06
Identities = 62/227 (27%), Positives = 103/227 (45%), Gaps = 26/227 (11%)
Query: 432 LNAGDELLEVNEYRLHGLTHSEVVNILKQLP--DRVRLVCARNSIDSGPRPVVNLASDRE 489
L GD + E+ + LTH +VV +LKQ P V L+ R S P + +D+
Sbjct: 638 LQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPS-PTKTAKMKTDK- 695
Query: 490 GFEARKIISGSLNNLTTLVKAQSD--TSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQ 547
K +GSL + + SI S + L + SE KS++L
Sbjct: 696 -----KENAGSLEAINEPIPQPMPFPPSIIRSGSPKL-DPSEVYLKSKTLYEDKPP---N 746
Query: 548 SKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVN 607
+K+ V L K + G GF +L P D + I + +++P G AEK+G + D +M ++
Sbjct: 747 TKDLDVFLRKQESGFGFRVLGGDGP-DQS---IYIGAIIPLGAAEKDGRLRAADELMCID 802
Query: 608 GVSIQNATLDQAVQALKGAPR-GTVKVGIARPL------PPQDSSKS 647
G+ ++ + Q + + A R G V + + R + P DSS++
Sbjct: 803 GIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQA 849
Score = 47.6 bits (108), Expect = 1e-04
Identities = 25/80 (31%), Positives = 42/80 (52%)
Query: 547 QSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSV 606
Q D+V+ K ++G GF IL ++ P + ++ G A++ G++ GD + +V
Sbjct: 872 QEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAV 931
Query: 607 NGVSIQNATLDQAVQALKGA 626
NG SI + D VQ +K A
Sbjct: 932 NGQSIVELSHDNIVQLIKDA 951
Score = 47.2 bits (107), Expect = 2e-04
Identities = 59/275 (21%), Positives = 112/275 (40%), Gaps = 32/275 (11%)
Query: 11 EVVELTNDGNGLGFNLVGGRST---GVV---IKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
+VV + G GF ++ ++ GV+ I V+ G AD+ +L+ GDH+ V +
Sbjct: 876 DVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQS 935
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVPTKILADPELLDRHLI 124
+ + + + +++ AG V L V + P GT P L R
Sbjct: 936 IVELSHDNIVQLIKDAGVTVTLTVIAEEEH----HGPPSGT----NSARQSPALQHR--- 984
Query: 125 ETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQKIPDHPIVCDSVSPTIT 184
+ Q +++ I G E I V DH + + I+
Sbjct: 985 --------PMGQSQANH-IPGDRSALEGEI---GKDVSTSYRHSWSDHKHLAQPDTAVIS 1032
Query: 185 ITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKI 244
+ + V+L + G G ++ G KE G+F+ + E A + G+I +
Sbjct: 1033 VVGSRHNQNLGCYPVELERGPRGFGFSLRG---GKEYNMGLFILRLAEDGPAIKDGRIHV 1089
Query: 245 NDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
D+I+E++G ++ +++E+++ G V L+L
Sbjct: 1090 GDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLL 1124
Score = 45.2 bits (102), Expect = 7e-04
Identities = 21/59 (35%), Positives = 38/59 (64%), Gaps = 2/59 (3%)
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHL--VLERYLRGP 286
+IEGS A++ GK+K+ D I V+G S+ + S+ V+++++ G++V L + E GP
Sbjct: 910 VIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGP 968
Score = 42.7 bits (96), Expect = 0.004
Identities = 29/81 (35%), Positives = 42/81 (51%), Gaps = 3/81 (3%)
Query: 13 VELTNDGNGLGFNLVGGR--STGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTS 70
VEL G GF+L GG+ + G+ I + G A KD R+ GD ++++ +G T
Sbjct: 1047 VELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITH 1106
Query: 71 EQVAAVLRQAGPVVRLLVARP 91
+ A L QAG LL+ RP
Sbjct: 1107 TR-AIELIQAGGNKVLLLLRP 1126
Score = 40.3 bits (90), Expect = 0.021
Identities = 17/64 (26%), Positives = 36/64 (56%)
Query: 405 VEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDR 464
+ GG+E +I + DGP G ++ GD+++E+N G+TH+ + +++ ++
Sbjct: 1060 LRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNK 1119
Query: 465 VRLV 468
V L+
Sbjct: 1120 VLLL 1123
Score = 39.5 bits (88), Expect = 0.037
Identities = 20/70 (28%), Positives = 39/70 (55%), Gaps = 2/70 (2%)
Query: 13 VELTNDGNGLGFNLVGGRST--GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTS 70
V L +G GF ++GG + I ++P G A+KD RL++ D ++ + + ++G +
Sbjct: 752 VFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSH 811
Query: 71 EQVAAVLRQA 80
+QV ++ A
Sbjct: 812 KQVLDLMTTA 821
Score = 31.9 bits (69), Expect = 7.4
Identities = 25/89 (28%), Positives = 40/89 (44%), Gaps = 6/89 (6%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGF 68
++ + L G GF + TG +K +L + LQ GD + ++ N++
Sbjct: 600 ELVTIPLIKGPKGFGF-AIADSPTGQKVKMILDSQWC---QGLQKGDIIKEIYHQNVQNL 655
Query: 69 TSEQVAAVLRQ--AGPVVRLLVARPADPA 95
T QV VL+Q G V LL+ R P+
Sbjct: 656 THLQVVEVLKQFPVGADVPLLILRGGPPS 684
Score = 31.5 bits (68), Expect = 9.7
Identities = 16/54 (29%), Positives = 29/54 (53%)
Query: 405 VEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNIL 458
V GG YI +++P G G L A DEL+ ++ + G +H +V++++
Sbjct: 765 VLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLM 818
>AL389921-2|CAH71509.1| 1125|Homo sapiens membrane associated
guanylate kinase, WW and PDZ domain containing 3
protein.
Length = 1125
Score = 59.7 bits (138), Expect = 3e-08
Identities = 63/247 (25%), Positives = 103/247 (41%), Gaps = 20/247 (8%)
Query: 412 RPHHY--IRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP--DRVRL 467
RP + +++VL DGP G + GD ++++N + G TH++VV + + +P V L
Sbjct: 429 RPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNL 488
Query: 468 VCARN--SIDSGPRPVVNLASDREGFEARKIISG-SLNNLTTLVKAQSDTSINTSSTATL 524
R D PVV++ + + + G + N N S TL
Sbjct: 489 TLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQDFKPGAMVLEQNGKSGHTL 548
Query: 525 TNHSEQSKKSRSLECVSGLAMWQSKEDIVM--LVKADQGLGFSILDYQDPVDPNGTVIVV 582
T S + VS + S+ ++V L+K +G GF+I D P +I+
Sbjct: 549 TGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAIAD--SPTGQKVKMILD 606
Query: 583 RSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGT-VKVGIARPLPP 641
G + GD + + ++QN T Q V+ LK P G V + I R PP
Sbjct: 607 SQWCQG--------LQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPP 658
Query: 642 QDSSKSK 648
+ +K
Sbjct: 659 SPTKTAK 665
Score = 58.0 bits (134), Expect = 1e-07
Identities = 49/214 (22%), Positives = 92/214 (42%), Gaps = 8/214 (3%)
Query: 415 HYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSI 474
H I V+ P G L GD + VN + L+H +V ++K V L
Sbjct: 880 HKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEE 939
Query: 475 DSGPRPVVNLASDREGFEARKIISGSLNNL---TTLVKAQSDTSINTSSTATLTNHSEQS 531
GP N A + R + N++ + ++ + ++TS + ++H +
Sbjct: 940 HHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLA 999
Query: 532 KKSRSLECVSGLAMWQSKEDI-VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGV 590
+ ++ V G Q+ V L + +G GFS+ + + N + ++R L G
Sbjct: 1000 QPDTAVISVVGSRHNQNLGCYPVELERGPRGFGFSL---RGGKEYNMGLFILR-LAEDGP 1055
Query: 591 AEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
A K+G I GD+++ +NG Q T +A++ ++
Sbjct: 1056 AIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQ 1089
Score = 53.2 bits (122), Expect = 3e-06
Identities = 62/227 (27%), Positives = 103/227 (45%), Gaps = 26/227 (11%)
Query: 432 LNAGDELLEVNEYRLHGLTHSEVVNILKQLP--DRVRLVCARNSIDSGPRPVVNLASDRE 489
L GD + E+ + LTH +VV +LKQ P V L+ R S P + +D+
Sbjct: 613 LQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPS-PTKTAKMKTDK- 670
Query: 490 GFEARKIISGSLNNLTTLVKAQSD--TSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQ 547
K +GSL + + SI S + L + SE KS++L
Sbjct: 671 -----KENAGSLEAINEPIPQPMPFPPSIIRSGSPKL-DPSEVYLKSKTLYEDKPP---N 721
Query: 548 SKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVN 607
+K+ V L K + G GF +L P D + I + +++P G AEK+G + D +M ++
Sbjct: 722 TKDLDVFLRKQESGFGFRVLGGDGP-DQS---IYIGAIIPLGAAEKDGRLRAADELMCID 777
Query: 608 GVSIQNATLDQAVQALKGAPR-GTVKVGIARPL------PPQDSSKS 647
G+ ++ + Q + + A R G V + + R + P DSS++
Sbjct: 778 GIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQA 824
Score = 47.6 bits (108), Expect = 1e-04
Identities = 25/80 (31%), Positives = 42/80 (52%)
Query: 547 QSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSV 606
Q D+V+ K ++G GF IL ++ P + ++ G A++ G++ GD + +V
Sbjct: 847 QEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAV 906
Query: 607 NGVSIQNATLDQAVQALKGA 626
NG SI + D VQ +K A
Sbjct: 907 NGQSIVELSHDNIVQLIKDA 926
Score = 47.2 bits (107), Expect = 2e-04
Identities = 59/275 (21%), Positives = 112/275 (40%), Gaps = 32/275 (11%)
Query: 11 EVVELTNDGNGLGFNLVGGRST---GVV---IKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
+VV + G GF ++ ++ GV+ I V+ G AD+ +L+ GDH+ V +
Sbjct: 851 DVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQS 910
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVPTKILADPELLDRHLI 124
+ + + + +++ AG V L V + P GT P L R
Sbjct: 911 IVELSHDNIVQLIKDAGVTVTLTVIAEEEH----HGPPSGT----NSARQSPALQHR--- 959
Query: 125 ETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQKIPDHPIVCDSVSPTIT 184
+ Q +++ I G E I V DH + + I+
Sbjct: 960 --------PMGQSQANH-IPGDRSALEGEI---GKDVSTSYRHSWSDHKHLAQPDTAVIS 1007
Query: 185 ITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKI 244
+ + V+L + G G ++ G KE G+F+ + E A + G+I +
Sbjct: 1008 VVGSRHNQNLGCYPVELERGPRGFGFSLRG---GKEYNMGLFILRLAEDGPAIKDGRIHV 1064
Query: 245 NDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
D+I+E++G ++ +++E+++ G V L+L
Sbjct: 1065 GDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLL 1099
Score = 45.2 bits (102), Expect = 7e-04
Identities = 21/59 (35%), Positives = 38/59 (64%), Gaps = 2/59 (3%)
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHL--VLERYLRGP 286
+IEGS A++ GK+K+ D I V+G S+ + S+ V+++++ G++V L + E GP
Sbjct: 885 VIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGP 943
Score = 42.7 bits (96), Expect = 0.004
Identities = 29/81 (35%), Positives = 42/81 (51%), Gaps = 3/81 (3%)
Query: 13 VELTNDGNGLGFNLVGGR--STGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTS 70
VEL G GF+L GG+ + G+ I + G A KD R+ GD ++++ +G T
Sbjct: 1022 VELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITH 1081
Query: 71 EQVAAVLRQAGPVVRLLVARP 91
+ A L QAG LL+ RP
Sbjct: 1082 TR-AIELIQAGGNKVLLLLRP 1101
Score = 40.3 bits (90), Expect = 0.021
Identities = 17/64 (26%), Positives = 36/64 (56%)
Query: 405 VEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDR 464
+ GG+E +I + DGP G ++ GD+++E+N G+TH+ + +++ ++
Sbjct: 1035 LRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNK 1094
Query: 465 VRLV 468
V L+
Sbjct: 1095 VLLL 1098
Score = 39.5 bits (88), Expect = 0.037
Identities = 20/70 (28%), Positives = 39/70 (55%), Gaps = 2/70 (2%)
Query: 13 VELTNDGNGLGFNLVGGRST--GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTS 70
V L +G GF ++GG + I ++P G A+KD RL++ D ++ + + ++G +
Sbjct: 727 VFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSH 786
Query: 71 EQVAAVLRQA 80
+QV ++ A
Sbjct: 787 KQVLDLMTTA 796
Score = 31.9 bits (69), Expect = 7.4
Identities = 25/89 (28%), Positives = 40/89 (44%), Gaps = 6/89 (6%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGF 68
++ + L G GF + TG +K +L + LQ GD + ++ N++
Sbjct: 575 ELVTIPLIKGPKGFGF-AIADSPTGQKVKMILDSQWC---QGLQKGDIIKEIYHQNVQNL 630
Query: 69 TSEQVAAVLRQ--AGPVVRLLVARPADPA 95
T QV VL+Q G V LL+ R P+
Sbjct: 631 THLQVVEVLKQFPVGADVPLLILRGGPPS 659
Score = 31.5 bits (68), Expect = 9.7
Identities = 16/54 (29%), Positives = 29/54 (53%)
Query: 405 VEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNIL 458
V GG YI +++P G G L A DEL+ ++ + G +H +V++++
Sbjct: 740 VLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLM 793
>AL389921-1|CAH71507.1| 1481|Homo sapiens membrane associated
guanylate kinase, WW and PDZ domain containing 3
protein.
Length = 1481
Score = 59.7 bits (138), Expect = 3e-08
Identities = 63/247 (25%), Positives = 103/247 (41%), Gaps = 20/247 (8%)
Query: 412 RPHHY--IRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP--DRVRL 467
RP + +++VL DGP G + GD ++++N + G TH++VV + + +P V L
Sbjct: 429 RPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNL 488
Query: 468 VCARN--SIDSGPRPVVNLASDREGFEARKIISG-SLNNLTTLVKAQSDTSINTSSTATL 524
R D PVV++ + + + G + N N S TL
Sbjct: 489 TLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQDFKPGAMVLEQNGKSGHTL 548
Query: 525 TNHSEQSKKSRSLECVSGLAMWQSKEDIVM--LVKADQGLGFSILDYQDPVDPNGTVIVV 582
T S + VS + S+ ++V L+K +G GF+I D P +I+
Sbjct: 549 TGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAIAD--SPTGQKVKMILD 606
Query: 583 RSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGT-VKVGIARPLPP 641
G + GD + + ++QN T Q V+ LK P G V + I R PP
Sbjct: 607 SQWCQG--------LQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPP 658
Query: 642 QDSSKSK 648
+ +K
Sbjct: 659 SPTKTAK 665
Score = 58.0 bits (134), Expect = 1e-07
Identities = 49/214 (22%), Positives = 92/214 (42%), Gaps = 8/214 (3%)
Query: 415 HYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSI 474
H I V+ P G L GD + VN + L+H +V ++K V L
Sbjct: 880 HKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEE 939
Query: 475 DSGPRPVVNLASDREGFEARKIISGSLNNL---TTLVKAQSDTSINTSSTATLTNHSEQS 531
GP N A + R + N++ + ++ + ++TS + ++H +
Sbjct: 940 HHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLA 999
Query: 532 KKSRSLECVSGLAMWQSKEDI-VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGV 590
+ ++ V G Q+ V L + +G GFS+ + + N + ++R L G
Sbjct: 1000 QPDTAVISVVGSRHNQNLGCYPVELERGPRGFGFSL---RGGKEYNMGLFILR-LAEDGP 1055
Query: 591 AEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
A K+G I GD+++ +NG Q T +A++ ++
Sbjct: 1056 AIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQ 1089
Score = 53.2 bits (122), Expect = 3e-06
Identities = 62/227 (27%), Positives = 103/227 (45%), Gaps = 26/227 (11%)
Query: 432 LNAGDELLEVNEYRLHGLTHSEVVNILKQLP--DRVRLVCARNSIDSGPRPVVNLASDRE 489
L GD + E+ + LTH +VV +LKQ P V L+ R S P + +D+
Sbjct: 613 LQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPS-PTKTAKMKTDK- 670
Query: 490 GFEARKIISGSLNNLTTLVKAQSD--TSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQ 547
K +GSL + + SI S + L + SE KS++L
Sbjct: 671 -----KENAGSLEAINEPIPQPMPFPPSIIRSGSPKL-DPSEVYLKSKTLYEDKPP---N 721
Query: 548 SKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVN 607
+K+ V L K + G GF +L P D + I + +++P G AEK+G + D +M ++
Sbjct: 722 TKDLDVFLRKQESGFGFRVLGGDGP-DQS---IYIGAIIPLGAAEKDGRLRAADELMCID 777
Query: 608 GVSIQNATLDQAVQALKGAPR-GTVKVGIARPL------PPQDSSKS 647
G+ ++ + Q + + A R G V + + R + P DSS++
Sbjct: 778 GIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQA 824
Score = 47.6 bits (108), Expect = 1e-04
Identities = 25/80 (31%), Positives = 42/80 (52%)
Query: 547 QSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSV 606
Q D+V+ K ++G GF IL ++ P + ++ G A++ G++ GD + +V
Sbjct: 847 QEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAV 906
Query: 607 NGVSIQNATLDQAVQALKGA 626
NG SI + D VQ +K A
Sbjct: 907 NGQSIVELSHDNIVQLIKDA 926
Score = 47.2 bits (107), Expect = 2e-04
Identities = 59/275 (21%), Positives = 112/275 (40%), Gaps = 32/275 (11%)
Query: 11 EVVELTNDGNGLGFNLVGGRST---GVV---IKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
+VV + G GF ++ ++ GV+ I V+ G AD+ +L+ GDH+ V +
Sbjct: 851 DVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQS 910
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVPTKILADPELLDRHLI 124
+ + + + +++ AG V L V + P GT P L R
Sbjct: 911 IVELSHDNIVQLIKDAGVTVTLTVIAEEEH----HGPPSGT----NSARQSPALQHR--- 959
Query: 125 ETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQKIPDHPIVCDSVSPTIT 184
+ Q +++ I G E I V DH + + I+
Sbjct: 960 --------PMGQSQANH-IPGDRSALEGEI---GKDVSTSYRHSWSDHKHLAQPDTAVIS 1007
Query: 185 ITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKI 244
+ + V+L + G G ++ G KE G+F+ + E A + G+I +
Sbjct: 1008 VVGSRHNQNLGCYPVELERGPRGFGFSLRG---GKEYNMGLFILRLAEDGPAIKDGRIHV 1064
Query: 245 NDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
D+I+E++G ++ +++E+++ G V L+L
Sbjct: 1065 GDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLL 1099
Score = 45.2 bits (102), Expect = 7e-04
Identities = 21/59 (35%), Positives = 38/59 (64%), Gaps = 2/59 (3%)
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHL--VLERYLRGP 286
+IEGS A++ GK+K+ D I V+G S+ + S+ V+++++ G++V L + E GP
Sbjct: 885 VIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGP 943
Score = 42.7 bits (96), Expect = 0.004
Identities = 29/81 (35%), Positives = 42/81 (51%), Gaps = 3/81 (3%)
Query: 13 VELTNDGNGLGFNLVGGR--STGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTS 70
VEL G GF+L GG+ + G+ I + G A KD R+ GD ++++ +G T
Sbjct: 1022 VELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITH 1081
Query: 71 EQVAAVLRQAGPVVRLLVARP 91
+ A L QAG LL+ RP
Sbjct: 1082 TR-AIELIQAGGNKVLLLLRP 1101
Score = 40.3 bits (90), Expect = 0.021
Identities = 17/64 (26%), Positives = 36/64 (56%)
Query: 405 VEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDR 464
+ GG+E +I + DGP G ++ GD+++E+N G+TH+ + +++ ++
Sbjct: 1035 LRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNK 1094
Query: 465 VRLV 468
V L+
Sbjct: 1095 VLLL 1098
Score = 39.5 bits (88), Expect = 0.037
Identities = 20/70 (28%), Positives = 39/70 (55%), Gaps = 2/70 (2%)
Query: 13 VELTNDGNGLGFNLVGGRST--GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTS 70
V L +G GF ++GG + I ++P G A+KD RL++ D ++ + + ++G +
Sbjct: 727 VFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSH 786
Query: 71 EQVAAVLRQA 80
+QV ++ A
Sbjct: 787 KQVLDLMTTA 796
Score = 31.9 bits (69), Expect = 7.4
Identities = 25/89 (28%), Positives = 40/89 (44%), Gaps = 6/89 (6%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGF 68
++ + L G GF + TG +K +L + LQ GD + ++ N++
Sbjct: 575 ELVTIPLIKGPKGFGF-AIADSPTGQKVKMILDSQWC---QGLQKGDIIKEIYHQNVQNL 630
Query: 69 TSEQVAAVLRQ--AGPVVRLLVARPADPA 95
T QV VL+Q G V LL+ R P+
Sbjct: 631 THLQVVEVLKQFPVGADVPLLILRGGPPS 659
Score = 31.5 bits (68), Expect = 9.7
Identities = 16/54 (29%), Positives = 29/54 (53%)
Query: 405 VEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNIL 458
V GG YI +++P G G L A DEL+ ++ + G +H +V++++
Sbjct: 740 VLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLM 793
>AL365225-3|CAH70945.1| 1150|Homo sapiens membrane associated
guanylate kinase, WW and PDZ domain containing 3
protein.
Length = 1150
Score = 59.7 bits (138), Expect = 3e-08
Identities = 63/247 (25%), Positives = 103/247 (41%), Gaps = 20/247 (8%)
Query: 412 RPHHY--IRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP--DRVRL 467
RP + +++VL DGP G + GD ++++N + G TH++VV + + +P V L
Sbjct: 454 RPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNL 513
Query: 468 VCARN--SIDSGPRPVVNLASDREGFEARKIISG-SLNNLTTLVKAQSDTSINTSSTATL 524
R D PVV++ + + + G + N N S TL
Sbjct: 514 TLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQDFKPGAMVLEQNGKSGHTL 573
Query: 525 TNHSEQSKKSRSLECVSGLAMWQSKEDIVM--LVKADQGLGFSILDYQDPVDPNGTVIVV 582
T S + VS + S+ ++V L+K +G GF+I D P +I+
Sbjct: 574 TGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAIAD--SPTGQKVKMILD 631
Query: 583 RSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGT-VKVGIARPLPP 641
G + GD + + ++QN T Q V+ LK P G V + I R PP
Sbjct: 632 SQWCQG--------LQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPP 683
Query: 642 QDSSKSK 648
+ +K
Sbjct: 684 SPTKTAK 690
Score = 58.0 bits (134), Expect = 1e-07
Identities = 49/214 (22%), Positives = 92/214 (42%), Gaps = 8/214 (3%)
Query: 415 HYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSI 474
H I V+ P G L GD + VN + L+H +V ++K V L
Sbjct: 905 HKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEE 964
Query: 475 DSGPRPVVNLASDREGFEARKIISGSLNNL---TTLVKAQSDTSINTSSTATLTNHSEQS 531
GP N A + R + N++ + ++ + ++TS + ++H +
Sbjct: 965 HHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLA 1024
Query: 532 KKSRSLECVSGLAMWQSKEDI-VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGV 590
+ ++ V G Q+ V L + +G GFS+ + + N + ++R L G
Sbjct: 1025 QPDTAVISVVGSRHNQNLGCYPVELERGPRGFGFSL---RGGKEYNMGLFILR-LAEDGP 1080
Query: 591 AEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
A K+G I GD+++ +NG Q T +A++ ++
Sbjct: 1081 AIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQ 1114
Score = 53.2 bits (122), Expect = 3e-06
Identities = 62/227 (27%), Positives = 103/227 (45%), Gaps = 26/227 (11%)
Query: 432 LNAGDELLEVNEYRLHGLTHSEVVNILKQLP--DRVRLVCARNSIDSGPRPVVNLASDRE 489
L GD + E+ + LTH +VV +LKQ P V L+ R S P + +D+
Sbjct: 638 LQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPS-PTKTAKMKTDK- 695
Query: 490 GFEARKIISGSLNNLTTLVKAQSD--TSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQ 547
K +GSL + + SI S + L + SE KS++L
Sbjct: 696 -----KENAGSLEAINEPIPQPMPFPPSIIRSGSPKL-DPSEVYLKSKTLYEDKPP---N 746
Query: 548 SKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVN 607
+K+ V L K + G GF +L P D + I + +++P G AEK+G + D +M ++
Sbjct: 747 TKDLDVFLRKQESGFGFRVLGGDGP-DQS---IYIGAIIPLGAAEKDGRLRAADELMCID 802
Query: 608 GVSIQNATLDQAVQALKGAPR-GTVKVGIARPL------PPQDSSKS 647
G+ ++ + Q + + A R G V + + R + P DSS++
Sbjct: 803 GIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQA 849
Score = 47.6 bits (108), Expect = 1e-04
Identities = 25/80 (31%), Positives = 42/80 (52%)
Query: 547 QSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSV 606
Q D+V+ K ++G GF IL ++ P + ++ G A++ G++ GD + +V
Sbjct: 872 QEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAV 931
Query: 607 NGVSIQNATLDQAVQALKGA 626
NG SI + D VQ +K A
Sbjct: 932 NGQSIVELSHDNIVQLIKDA 951
Score = 47.2 bits (107), Expect = 2e-04
Identities = 59/275 (21%), Positives = 112/275 (40%), Gaps = 32/275 (11%)
Query: 11 EVVELTNDGNGLGFNLVGGRST---GVV---IKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
+VV + G GF ++ ++ GV+ I V+ G AD+ +L+ GDH+ V +
Sbjct: 876 DVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQS 935
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVPTKILADPELLDRHLI 124
+ + + + +++ AG V L V + P GT P L R
Sbjct: 936 IVELSHDNIVQLIKDAGVTVTLTVIAEEEH----HGPPSGT----NSARQSPALQHR--- 984
Query: 125 ETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQKIPDHPIVCDSVSPTIT 184
+ Q +++ I G E I V DH + + I+
Sbjct: 985 --------PMGQSQANH-IPGDRSALEGEI---GKDVSTSYRHSWSDHKHLAQPDTAVIS 1032
Query: 185 ITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKI 244
+ + V+L + G G ++ G KE G+F+ + E A + G+I +
Sbjct: 1033 VVGSRHNQNLGCYPVELERGPRGFGFSLRG---GKEYNMGLFILRLAEDGPAIKDGRIHV 1089
Query: 245 NDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
D+I+E++G ++ +++E+++ G V L+L
Sbjct: 1090 GDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLL 1124
Score = 45.2 bits (102), Expect = 7e-04
Identities = 21/59 (35%), Positives = 38/59 (64%), Gaps = 2/59 (3%)
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHL--VLERYLRGP 286
+IEGS A++ GK+K+ D I V+G S+ + S+ V+++++ G++V L + E GP
Sbjct: 910 VIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGP 968
Score = 42.7 bits (96), Expect = 0.004
Identities = 29/81 (35%), Positives = 42/81 (51%), Gaps = 3/81 (3%)
Query: 13 VELTNDGNGLGFNLVGGR--STGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTS 70
VEL G GF+L GG+ + G+ I + G A KD R+ GD ++++ +G T
Sbjct: 1047 VELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITH 1106
Query: 71 EQVAAVLRQAGPVVRLLVARP 91
+ A L QAG LL+ RP
Sbjct: 1107 TR-AIELIQAGGNKVLLLLRP 1126
Score = 40.3 bits (90), Expect = 0.021
Identities = 17/64 (26%), Positives = 36/64 (56%)
Query: 405 VEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDR 464
+ GG+E +I + DGP G ++ GD+++E+N G+TH+ + +++ ++
Sbjct: 1060 LRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNK 1119
Query: 465 VRLV 468
V L+
Sbjct: 1120 VLLL 1123
Score = 39.5 bits (88), Expect = 0.037
Identities = 20/70 (28%), Positives = 39/70 (55%), Gaps = 2/70 (2%)
Query: 13 VELTNDGNGLGFNLVGGRST--GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTS 70
V L +G GF ++GG + I ++P G A+KD RL++ D ++ + + ++G +
Sbjct: 752 VFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSH 811
Query: 71 EQVAAVLRQA 80
+QV ++ A
Sbjct: 812 KQVLDLMTTA 821
Score = 31.9 bits (69), Expect = 7.4
Identities = 25/89 (28%), Positives = 40/89 (44%), Gaps = 6/89 (6%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGF 68
++ + L G GF + TG +K +L + LQ GD + ++ N++
Sbjct: 600 ELVTIPLIKGPKGFGF-AIADSPTGQKVKMILDSQWC---QGLQKGDIIKEIYHQNVQNL 655
Query: 69 TSEQVAAVLRQ--AGPVVRLLVARPADPA 95
T QV VL+Q G V LL+ R P+
Sbjct: 656 THLQVVEVLKQFPVGADVPLLILRGGPPS 684
Score = 31.5 bits (68), Expect = 9.7
Identities = 16/54 (29%), Positives = 29/54 (53%)
Query: 405 VEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNIL 458
V GG YI +++P G G L A DEL+ ++ + G +H +V++++
Sbjct: 765 VLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLM 818
>AL365225-2|CAH70946.1| 1125|Homo sapiens membrane associated
guanylate kinase, WW and PDZ domain containing 3
protein.
Length = 1125
Score = 59.7 bits (138), Expect = 3e-08
Identities = 63/247 (25%), Positives = 103/247 (41%), Gaps = 20/247 (8%)
Query: 412 RPHHY--IRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP--DRVRL 467
RP + +++VL DGP G + GD ++++N + G TH++VV + + +P V L
Sbjct: 429 RPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNL 488
Query: 468 VCARN--SIDSGPRPVVNLASDREGFEARKIISG-SLNNLTTLVKAQSDTSINTSSTATL 524
R D PVV++ + + + G + N N S TL
Sbjct: 489 TLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQDFKPGAMVLEQNGKSGHTL 548
Query: 525 TNHSEQSKKSRSLECVSGLAMWQSKEDIVM--LVKADQGLGFSILDYQDPVDPNGTVIVV 582
T S + VS + S+ ++V L+K +G GF+I D P +I+
Sbjct: 549 TGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAIAD--SPTGQKVKMILD 606
Query: 583 RSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGT-VKVGIARPLPP 641
G + GD + + ++QN T Q V+ LK P G V + I R PP
Sbjct: 607 SQWCQG--------LQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPP 658
Query: 642 QDSSKSK 648
+ +K
Sbjct: 659 SPTKTAK 665
Score = 58.0 bits (134), Expect = 1e-07
Identities = 49/214 (22%), Positives = 92/214 (42%), Gaps = 8/214 (3%)
Query: 415 HYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSI 474
H I V+ P G L GD + VN + L+H +V ++K V L
Sbjct: 880 HKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEE 939
Query: 475 DSGPRPVVNLASDREGFEARKIISGSLNNL---TTLVKAQSDTSINTSSTATLTNHSEQS 531
GP N A + R + N++ + ++ + ++TS + ++H +
Sbjct: 940 HHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLA 999
Query: 532 KKSRSLECVSGLAMWQSKEDI-VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGV 590
+ ++ V G Q+ V L + +G GFS+ + + N + ++R L G
Sbjct: 1000 QPDTAVISVVGSRHNQNLGCYPVELERGPRGFGFSL---RGGKEYNMGLFILR-LAEDGP 1055
Query: 591 AEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
A K+G I GD+++ +NG Q T +A++ ++
Sbjct: 1056 AIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQ 1089
Score = 53.2 bits (122), Expect = 3e-06
Identities = 62/227 (27%), Positives = 103/227 (45%), Gaps = 26/227 (11%)
Query: 432 LNAGDELLEVNEYRLHGLTHSEVVNILKQLP--DRVRLVCARNSIDSGPRPVVNLASDRE 489
L GD + E+ + LTH +VV +LKQ P V L+ R S P + +D+
Sbjct: 613 LQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPS-PTKTAKMKTDK- 670
Query: 490 GFEARKIISGSLNNLTTLVKAQSD--TSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQ 547
K +GSL + + SI S + L + SE KS++L
Sbjct: 671 -----KENAGSLEAINEPIPQPMPFPPSIIRSGSPKL-DPSEVYLKSKTLYEDKPP---N 721
Query: 548 SKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVN 607
+K+ V L K + G GF +L P D + I + +++P G AEK+G + D +M ++
Sbjct: 722 TKDLDVFLRKQESGFGFRVLGGDGP-DQS---IYIGAIIPLGAAEKDGRLRAADELMCID 777
Query: 608 GVSIQNATLDQAVQALKGAPR-GTVKVGIARPL------PPQDSSKS 647
G+ ++ + Q + + A R G V + + R + P DSS++
Sbjct: 778 GIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQA 824
Score = 47.6 bits (108), Expect = 1e-04
Identities = 25/80 (31%), Positives = 42/80 (52%)
Query: 547 QSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSV 606
Q D+V+ K ++G GF IL ++ P + ++ G A++ G++ GD + +V
Sbjct: 847 QEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAV 906
Query: 607 NGVSIQNATLDQAVQALKGA 626
NG SI + D VQ +K A
Sbjct: 907 NGQSIVELSHDNIVQLIKDA 926
Score = 47.2 bits (107), Expect = 2e-04
Identities = 59/275 (21%), Positives = 112/275 (40%), Gaps = 32/275 (11%)
Query: 11 EVVELTNDGNGLGFNLVGGRST---GVV---IKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
+VV + G GF ++ ++ GV+ I V+ G AD+ +L+ GDH+ V +
Sbjct: 851 DVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQS 910
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVPTKILADPELLDRHLI 124
+ + + + +++ AG V L V + P GT P L R
Sbjct: 911 IVELSHDNIVQLIKDAGVTVTLTVIAEEEH----HGPPSGT----NSARQSPALQHR--- 959
Query: 125 ETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQKIPDHPIVCDSVSPTIT 184
+ Q +++ I G E I V DH + + I+
Sbjct: 960 --------PMGQSQANH-IPGDRSALEGEI---GKDVSTSYRHSWSDHKHLAQPDTAVIS 1007
Query: 185 ITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKI 244
+ + V+L + G G ++ G KE G+F+ + E A + G+I +
Sbjct: 1008 VVGSRHNQNLGCYPVELERGPRGFGFSLRG---GKEYNMGLFILRLAEDGPAIKDGRIHV 1064
Query: 245 NDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
D+I+E++G ++ +++E+++ G V L+L
Sbjct: 1065 GDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLL 1099
Score = 45.2 bits (102), Expect = 7e-04
Identities = 21/59 (35%), Positives = 38/59 (64%), Gaps = 2/59 (3%)
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHL--VLERYLRGP 286
+IEGS A++ GK+K+ D I V+G S+ + S+ V+++++ G++V L + E GP
Sbjct: 885 VIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGP 943
Score = 42.7 bits (96), Expect = 0.004
Identities = 29/81 (35%), Positives = 42/81 (51%), Gaps = 3/81 (3%)
Query: 13 VELTNDGNGLGFNLVGGR--STGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTS 70
VEL G GF+L GG+ + G+ I + G A KD R+ GD ++++ +G T
Sbjct: 1022 VELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITH 1081
Query: 71 EQVAAVLRQAGPVVRLLVARP 91
+ A L QAG LL+ RP
Sbjct: 1082 TR-AIELIQAGGNKVLLLLRP 1101
Score = 40.3 bits (90), Expect = 0.021
Identities = 17/64 (26%), Positives = 36/64 (56%)
Query: 405 VEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDR 464
+ GG+E +I + DGP G ++ GD+++E+N G+TH+ + +++ ++
Sbjct: 1035 LRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNK 1094
Query: 465 VRLV 468
V L+
Sbjct: 1095 VLLL 1098
Score = 39.5 bits (88), Expect = 0.037
Identities = 20/70 (28%), Positives = 39/70 (55%), Gaps = 2/70 (2%)
Query: 13 VELTNDGNGLGFNLVGGRST--GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTS 70
V L +G GF ++GG + I ++P G A+KD RL++ D ++ + + ++G +
Sbjct: 727 VFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSH 786
Query: 71 EQVAAVLRQA 80
+QV ++ A
Sbjct: 787 KQVLDLMTTA 796
Score = 31.9 bits (69), Expect = 7.4
Identities = 25/89 (28%), Positives = 40/89 (44%), Gaps = 6/89 (6%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGF 68
++ + L G GF + TG +K +L + LQ GD + ++ N++
Sbjct: 575 ELVTIPLIKGPKGFGF-AIADSPTGQKVKMILDSQWC---QGLQKGDIIKEIYHQNVQNL 630
Query: 69 TSEQVAAVLRQ--AGPVVRLLVARPADPA 95
T QV VL+Q G V LL+ R P+
Sbjct: 631 THLQVVEVLKQFPVGADVPLLILRGGPPS 659
Score = 31.5 bits (68), Expect = 9.7
Identities = 16/54 (29%), Positives = 29/54 (53%)
Query: 405 VEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNIL 458
V GG YI +++P G G L A DEL+ ++ + G +H +V++++
Sbjct: 740 VLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLM 793
>AL365225-1|CAH70944.1| 1481|Homo sapiens membrane associated
guanylate kinase, WW and PDZ domain containing 3
protein.
Length = 1481
Score = 59.7 bits (138), Expect = 3e-08
Identities = 63/247 (25%), Positives = 103/247 (41%), Gaps = 20/247 (8%)
Query: 412 RPHHY--IRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP--DRVRL 467
RP + +++VL DGP G + GD ++++N + G TH++VV + + +P V L
Sbjct: 429 RPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNL 488
Query: 468 VCARN--SIDSGPRPVVNLASDREGFEARKIISG-SLNNLTTLVKAQSDTSINTSSTATL 524
R D PVV++ + + + G + N N S TL
Sbjct: 489 TLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQDFKPGAMVLEQNGKSGHTL 548
Query: 525 TNHSEQSKKSRSLECVSGLAMWQSKEDIVM--LVKADQGLGFSILDYQDPVDPNGTVIVV 582
T S + VS + S+ ++V L+K +G GF+I D P +I+
Sbjct: 549 TGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAIAD--SPTGQKVKMILD 606
Query: 583 RSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGT-VKVGIARPLPP 641
G + GD + + ++QN T Q V+ LK P G V + I R PP
Sbjct: 607 SQWCQG--------LQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPP 658
Query: 642 QDSSKSK 648
+ +K
Sbjct: 659 SPTKTAK 665
Score = 58.0 bits (134), Expect = 1e-07
Identities = 49/214 (22%), Positives = 92/214 (42%), Gaps = 8/214 (3%)
Query: 415 HYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSI 474
H I V+ P G L GD + VN + L+H +V ++K V L
Sbjct: 880 HKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEE 939
Query: 475 DSGPRPVVNLASDREGFEARKIISGSLNNL---TTLVKAQSDTSINTSSTATLTNHSEQS 531
GP N A + R + N++ + ++ + ++TS + ++H +
Sbjct: 940 HHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLA 999
Query: 532 KKSRSLECVSGLAMWQSKEDI-VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGV 590
+ ++ V G Q+ V L + +G GFS+ + + N + ++R L G
Sbjct: 1000 QPDTAVISVVGSRHNQNLGCYPVELERGPRGFGFSL---RGGKEYNMGLFILR-LAEDGP 1055
Query: 591 AEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
A K+G I GD+++ +NG Q T +A++ ++
Sbjct: 1056 AIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQ 1089
Score = 53.2 bits (122), Expect = 3e-06
Identities = 62/227 (27%), Positives = 103/227 (45%), Gaps = 26/227 (11%)
Query: 432 LNAGDELLEVNEYRLHGLTHSEVVNILKQLP--DRVRLVCARNSIDSGPRPVVNLASDRE 489
L GD + E+ + LTH +VV +LKQ P V L+ R S P + +D+
Sbjct: 613 LQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPS-PTKTAKMKTDK- 670
Query: 490 GFEARKIISGSLNNLTTLVKAQSD--TSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQ 547
K +GSL + + SI S + L + SE KS++L
Sbjct: 671 -----KENAGSLEAINEPIPQPMPFPPSIIRSGSPKL-DPSEVYLKSKTLYEDKPP---N 721
Query: 548 SKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVN 607
+K+ V L K + G GF +L P D + I + +++P G AEK+G + D +M ++
Sbjct: 722 TKDLDVFLRKQESGFGFRVLGGDGP-DQS---IYIGAIIPLGAAEKDGRLRAADELMCID 777
Query: 608 GVSIQNATLDQAVQALKGAPR-GTVKVGIARPL------PPQDSSKS 647
G+ ++ + Q + + A R G V + + R + P DSS++
Sbjct: 778 GIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQA 824
Score = 47.6 bits (108), Expect = 1e-04
Identities = 25/80 (31%), Positives = 42/80 (52%)
Query: 547 QSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSV 606
Q D+V+ K ++G GF IL ++ P + ++ G A++ G++ GD + +V
Sbjct: 847 QEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAV 906
Query: 607 NGVSIQNATLDQAVQALKGA 626
NG SI + D VQ +K A
Sbjct: 907 NGQSIVELSHDNIVQLIKDA 926
Score = 47.2 bits (107), Expect = 2e-04
Identities = 59/275 (21%), Positives = 112/275 (40%), Gaps = 32/275 (11%)
Query: 11 EVVELTNDGNGLGFNLVGGRST---GVV---IKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
+VV + G GF ++ ++ GV+ I V+ G AD+ +L+ GDH+ V +
Sbjct: 851 DVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQS 910
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVPTKILADPELLDRHLI 124
+ + + + +++ AG V L V + P GT P L R
Sbjct: 911 IVELSHDNIVQLIKDAGVTVTLTVIAEEEH----HGPPSGT----NSARQSPALQHR--- 959
Query: 125 ETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQKIPDHPIVCDSVSPTIT 184
+ Q +++ I G E I V DH + + I+
Sbjct: 960 --------PMGQSQANH-IPGDRSALEGEI---GKDVSTSYRHSWSDHKHLAQPDTAVIS 1007
Query: 185 ITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKI 244
+ + V+L + G G ++ G KE G+F+ + E A + G+I +
Sbjct: 1008 VVGSRHNQNLGCYPVELERGPRGFGFSLRG---GKEYNMGLFILRLAEDGPAIKDGRIHV 1064
Query: 245 NDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
D+I+E++G ++ +++E+++ G V L+L
Sbjct: 1065 GDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLL 1099
Score = 45.2 bits (102), Expect = 7e-04
Identities = 21/59 (35%), Positives = 38/59 (64%), Gaps = 2/59 (3%)
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHL--VLERYLRGP 286
+IEGS A++ GK+K+ D I V+G S+ + S+ V+++++ G++V L + E GP
Sbjct: 885 VIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGP 943
Score = 42.7 bits (96), Expect = 0.004
Identities = 29/81 (35%), Positives = 42/81 (51%), Gaps = 3/81 (3%)
Query: 13 VELTNDGNGLGFNLVGGR--STGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTS 70
VEL G GF+L GG+ + G+ I + G A KD R+ GD ++++ +G T
Sbjct: 1022 VELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITH 1081
Query: 71 EQVAAVLRQAGPVVRLLVARP 91
+ A L QAG LL+ RP
Sbjct: 1082 TR-AIELIQAGGNKVLLLLRP 1101
Score = 40.3 bits (90), Expect = 0.021
Identities = 17/64 (26%), Positives = 36/64 (56%)
Query: 405 VEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDR 464
+ GG+E +I + DGP G ++ GD+++E+N G+TH+ + +++ ++
Sbjct: 1035 LRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNK 1094
Query: 465 VRLV 468
V L+
Sbjct: 1095 VLLL 1098
Score = 39.5 bits (88), Expect = 0.037
Identities = 20/70 (28%), Positives = 39/70 (55%), Gaps = 2/70 (2%)
Query: 13 VELTNDGNGLGFNLVGGRST--GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTS 70
V L +G GF ++GG + I ++P G A+KD RL++ D ++ + + ++G +
Sbjct: 727 VFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSH 786
Query: 71 EQVAAVLRQA 80
+QV ++ A
Sbjct: 787 KQVLDLMTTA 796
Score = 31.9 bits (69), Expect = 7.4
Identities = 25/89 (28%), Positives = 40/89 (44%), Gaps = 6/89 (6%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGF 68
++ + L G GF + TG +K +L + LQ GD + ++ N++
Sbjct: 575 ELVTIPLIKGPKGFGF-AIADSPTGQKVKMILDSQWC---QGLQKGDIIKEIYHQNVQNL 630
Query: 69 TSEQVAAVLRQ--AGPVVRLLVARPADPA 95
T QV VL+Q G V LL+ R P+
Sbjct: 631 THLQVVEVLKQFPVGADVPLLILRGGPPS 659
Score = 31.5 bits (68), Expect = 9.7
Identities = 16/54 (29%), Positives = 29/54 (53%)
Query: 405 VEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNIL 458
V GG YI +++P G G L A DEL+ ++ + G +H +V++++
Sbjct: 740 VLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLM 793
>AL133517-10|CAI22555.1| 1125|Homo sapiens membrane associated
guanylate kinase, WW and PDZ domain containing 3
protein.
Length = 1125
Score = 59.7 bits (138), Expect = 3e-08
Identities = 63/247 (25%), Positives = 103/247 (41%), Gaps = 20/247 (8%)
Query: 412 RPHHY--IRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP--DRVRL 467
RP + +++VL DGP G + GD ++++N + G TH++VV + + +P V L
Sbjct: 429 RPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNL 488
Query: 468 VCARN--SIDSGPRPVVNLASDREGFEARKIISG-SLNNLTTLVKAQSDTSINTSSTATL 524
R D PVV++ + + + G + N N S TL
Sbjct: 489 TLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQDFKPGAMVLEQNGKSGHTL 548
Query: 525 TNHSEQSKKSRSLECVSGLAMWQSKEDIVM--LVKADQGLGFSILDYQDPVDPNGTVIVV 582
T S + VS + S+ ++V L+K +G GF+I D P +I+
Sbjct: 549 TGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAIAD--SPTGQKVKMILD 606
Query: 583 RSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGT-VKVGIARPLPP 641
G + GD + + ++QN T Q V+ LK P G V + I R PP
Sbjct: 607 SQWCQG--------LQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPP 658
Query: 642 QDSSKSK 648
+ +K
Sbjct: 659 SPTKTAK 665
Score = 58.0 bits (134), Expect = 1e-07
Identities = 49/214 (22%), Positives = 92/214 (42%), Gaps = 8/214 (3%)
Query: 415 HYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSI 474
H I V+ P G L GD + VN + L+H +V ++K V L
Sbjct: 880 HKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEE 939
Query: 475 DSGPRPVVNLASDREGFEARKIISGSLNNL---TTLVKAQSDTSINTSSTATLTNHSEQS 531
GP N A + R + N++ + ++ + ++TS + ++H +
Sbjct: 940 HHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLA 999
Query: 532 KKSRSLECVSGLAMWQSKEDI-VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGV 590
+ ++ V G Q+ V L + +G GFS+ + + N + ++R L G
Sbjct: 1000 QPDTAVISVVGSRHNQNLGCYPVELERGPRGFGFSL---RGGKEYNMGLFILR-LAEDGP 1055
Query: 591 AEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
A K+G I GD+++ +NG Q T +A++ ++
Sbjct: 1056 AIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQ 1089
Score = 53.2 bits (122), Expect = 3e-06
Identities = 62/227 (27%), Positives = 103/227 (45%), Gaps = 26/227 (11%)
Query: 432 LNAGDELLEVNEYRLHGLTHSEVVNILKQLP--DRVRLVCARNSIDSGPRPVVNLASDRE 489
L GD + E+ + LTH +VV +LKQ P V L+ R S P + +D+
Sbjct: 613 LQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPS-PTKTAKMKTDK- 670
Query: 490 GFEARKIISGSLNNLTTLVKAQSD--TSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQ 547
K +GSL + + SI S + L + SE KS++L
Sbjct: 671 -----KENAGSLEAINEPIPQPMPFPPSIIRSGSPKL-DPSEVYLKSKTLYEDKPP---N 721
Query: 548 SKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVN 607
+K+ V L K + G GF +L P D + I + +++P G AEK+G + D +M ++
Sbjct: 722 TKDLDVFLRKQESGFGFRVLGGDGP-DQS---IYIGAIIPLGAAEKDGRLRAADELMCID 777
Query: 608 GVSIQNATLDQAVQALKGAPR-GTVKVGIARPL------PPQDSSKS 647
G+ ++ + Q + + A R G V + + R + P DSS++
Sbjct: 778 GIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQA 824
Score = 47.6 bits (108), Expect = 1e-04
Identities = 25/80 (31%), Positives = 42/80 (52%)
Query: 547 QSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSV 606
Q D+V+ K ++G GF IL ++ P + ++ G A++ G++ GD + +V
Sbjct: 847 QEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAV 906
Query: 607 NGVSIQNATLDQAVQALKGA 626
NG SI + D VQ +K A
Sbjct: 907 NGQSIVELSHDNIVQLIKDA 926
Score = 47.2 bits (107), Expect = 2e-04
Identities = 59/275 (21%), Positives = 112/275 (40%), Gaps = 32/275 (11%)
Query: 11 EVVELTNDGNGLGFNLVGGRST---GVV---IKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
+VV + G GF ++ ++ GV+ I V+ G AD+ +L+ GDH+ V +
Sbjct: 851 DVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQS 910
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVPTKILADPELLDRHLI 124
+ + + + +++ AG V L V + P GT P L R
Sbjct: 911 IVELSHDNIVQLIKDAGVTVTLTVIAEEEH----HGPPSGT----NSARQSPALQHR--- 959
Query: 125 ETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQKIPDHPIVCDSVSPTIT 184
+ Q +++ I G E I V DH + + I+
Sbjct: 960 --------PMGQSQANH-IPGDRSALEGEI---GKDVSTSYRHSWSDHKHLAQPDTAVIS 1007
Query: 185 ITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKI 244
+ + V+L + G G ++ G KE G+F+ + E A + G+I +
Sbjct: 1008 VVGSRHNQNLGCYPVELERGPRGFGFSLRG---GKEYNMGLFILRLAEDGPAIKDGRIHV 1064
Query: 245 NDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
D+I+E++G ++ +++E+++ G V L+L
Sbjct: 1065 GDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLL 1099
Score = 45.2 bits (102), Expect = 7e-04
Identities = 21/59 (35%), Positives = 38/59 (64%), Gaps = 2/59 (3%)
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHL--VLERYLRGP 286
+IEGS A++ GK+K+ D I V+G S+ + S+ V+++++ G++V L + E GP
Sbjct: 885 VIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGP 943
Score = 42.7 bits (96), Expect = 0.004
Identities = 29/81 (35%), Positives = 42/81 (51%), Gaps = 3/81 (3%)
Query: 13 VELTNDGNGLGFNLVGGR--STGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTS 70
VEL G GF+L GG+ + G+ I + G A KD R+ GD ++++ +G T
Sbjct: 1022 VELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITH 1081
Query: 71 EQVAAVLRQAGPVVRLLVARP 91
+ A L QAG LL+ RP
Sbjct: 1082 TR-AIELIQAGGNKVLLLLRP 1101
Score = 40.3 bits (90), Expect = 0.021
Identities = 17/64 (26%), Positives = 36/64 (56%)
Query: 405 VEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDR 464
+ GG+E +I + DGP G ++ GD+++E+N G+TH+ + +++ ++
Sbjct: 1035 LRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNK 1094
Query: 465 VRLV 468
V L+
Sbjct: 1095 VLLL 1098
Score = 39.5 bits (88), Expect = 0.037
Identities = 20/70 (28%), Positives = 39/70 (55%), Gaps = 2/70 (2%)
Query: 13 VELTNDGNGLGFNLVGGRST--GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTS 70
V L +G GF ++GG + I ++P G A+KD RL++ D ++ + + ++G +
Sbjct: 727 VFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSH 786
Query: 71 EQVAAVLRQA 80
+QV ++ A
Sbjct: 787 KQVLDLMTTA 796
Score = 31.9 bits (69), Expect = 7.4
Identities = 25/89 (28%), Positives = 40/89 (44%), Gaps = 6/89 (6%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGF 68
++ + L G GF + TG +K +L + LQ GD + ++ N++
Sbjct: 575 ELVTIPLIKGPKGFGF-AIADSPTGQKVKMILDSQWC---QGLQKGDIIKEIYHQNVQNL 630
Query: 69 TSEQVAAVLRQ--AGPVVRLLVARPADPA 95
T QV VL+Q G V LL+ R P+
Sbjct: 631 THLQVVEVLKQFPVGADVPLLILRGGPPS 659
Score = 31.5 bits (68), Expect = 9.7
Identities = 16/54 (29%), Positives = 29/54 (53%)
Query: 405 VEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNIL 458
V GG YI +++P G G L A DEL+ ++ + G +H +V++++
Sbjct: 740 VLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLM 793
>AL133517-9|CAI22554.1| 1150|Homo sapiens membrane associated
guanylate kinase, WW and PDZ domain containing 3
protein.
Length = 1150
Score = 59.7 bits (138), Expect = 3e-08
Identities = 63/247 (25%), Positives = 103/247 (41%), Gaps = 20/247 (8%)
Query: 412 RPHHY--IRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP--DRVRL 467
RP + +++VL DGP G + GD ++++N + G TH++VV + + +P V L
Sbjct: 454 RPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNL 513
Query: 468 VCARN--SIDSGPRPVVNLASDREGFEARKIISG-SLNNLTTLVKAQSDTSINTSSTATL 524
R D PVV++ + + + G + N N S TL
Sbjct: 514 TLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQDFKPGAMVLEQNGKSGHTL 573
Query: 525 TNHSEQSKKSRSLECVSGLAMWQSKEDIVM--LVKADQGLGFSILDYQDPVDPNGTVIVV 582
T S + VS + S+ ++V L+K +G GF+I D P +I+
Sbjct: 574 TGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAIAD--SPTGQKVKMILD 631
Query: 583 RSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGT-VKVGIARPLPP 641
G + GD + + ++QN T Q V+ LK P G V + I R PP
Sbjct: 632 SQWCQG--------LQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPP 683
Query: 642 QDSSKSK 648
+ +K
Sbjct: 684 SPTKTAK 690
Score = 58.0 bits (134), Expect = 1e-07
Identities = 49/214 (22%), Positives = 92/214 (42%), Gaps = 8/214 (3%)
Query: 415 HYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSI 474
H I V+ P G L GD + VN + L+H +V ++K V L
Sbjct: 905 HKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEE 964
Query: 475 DSGPRPVVNLASDREGFEARKIISGSLNNL---TTLVKAQSDTSINTSSTATLTNHSEQS 531
GP N A + R + N++ + ++ + ++TS + ++H +
Sbjct: 965 HHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLA 1024
Query: 532 KKSRSLECVSGLAMWQSKEDI-VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGV 590
+ ++ V G Q+ V L + +G GFS+ + + N + ++R L G
Sbjct: 1025 QPDTAVISVVGSRHNQNLGCYPVELERGPRGFGFSL---RGGKEYNMGLFILR-LAEDGP 1080
Query: 591 AEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
A K+G I GD+++ +NG Q T +A++ ++
Sbjct: 1081 AIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQ 1114
Score = 53.2 bits (122), Expect = 3e-06
Identities = 62/227 (27%), Positives = 103/227 (45%), Gaps = 26/227 (11%)
Query: 432 LNAGDELLEVNEYRLHGLTHSEVVNILKQLP--DRVRLVCARNSIDSGPRPVVNLASDRE 489
L GD + E+ + LTH +VV +LKQ P V L+ R S P + +D+
Sbjct: 638 LQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPS-PTKTAKMKTDK- 695
Query: 490 GFEARKIISGSLNNLTTLVKAQSD--TSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQ 547
K +GSL + + SI S + L + SE KS++L
Sbjct: 696 -----KENAGSLEAINEPIPQPMPFPPSIIRSGSPKL-DPSEVYLKSKTLYEDKPP---N 746
Query: 548 SKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVN 607
+K+ V L K + G GF +L P D + I + +++P G AEK+G + D +M ++
Sbjct: 747 TKDLDVFLRKQESGFGFRVLGGDGP-DQS---IYIGAIIPLGAAEKDGRLRAADELMCID 802
Query: 608 GVSIQNATLDQAVQALKGAPR-GTVKVGIARPL------PPQDSSKS 647
G+ ++ + Q + + A R G V + + R + P DSS++
Sbjct: 803 GIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQA 849
Score = 47.6 bits (108), Expect = 1e-04
Identities = 25/80 (31%), Positives = 42/80 (52%)
Query: 547 QSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSV 606
Q D+V+ K ++G GF IL ++ P + ++ G A++ G++ GD + +V
Sbjct: 872 QEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAV 931
Query: 607 NGVSIQNATLDQAVQALKGA 626
NG SI + D VQ +K A
Sbjct: 932 NGQSIVELSHDNIVQLIKDA 951
Score = 47.2 bits (107), Expect = 2e-04
Identities = 59/275 (21%), Positives = 112/275 (40%), Gaps = 32/275 (11%)
Query: 11 EVVELTNDGNGLGFNLVGGRST---GVV---IKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
+VV + G GF ++ ++ GV+ I V+ G AD+ +L+ GDH+ V +
Sbjct: 876 DVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQS 935
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVPTKILADPELLDRHLI 124
+ + + + +++ AG V L V + P GT P L R
Sbjct: 936 IVELSHDNIVQLIKDAGVTVTLTVIAEEEH----HGPPSGT----NSARQSPALQHR--- 984
Query: 125 ETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQKIPDHPIVCDSVSPTIT 184
+ Q +++ I G E I V DH + + I+
Sbjct: 985 --------PMGQSQANH-IPGDRSALEGEI---GKDVSTSYRHSWSDHKHLAQPDTAVIS 1032
Query: 185 ITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKI 244
+ + V+L + G G ++ G KE G+F+ + E A + G+I +
Sbjct: 1033 VVGSRHNQNLGCYPVELERGPRGFGFSLRG---GKEYNMGLFILRLAEDGPAIKDGRIHV 1089
Query: 245 NDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
D+I+E++G ++ +++E+++ G V L+L
Sbjct: 1090 GDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLL 1124
Score = 45.2 bits (102), Expect = 7e-04
Identities = 21/59 (35%), Positives = 38/59 (64%), Gaps = 2/59 (3%)
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHL--VLERYLRGP 286
+IEGS A++ GK+K+ D I V+G S+ + S+ V+++++ G++V L + E GP
Sbjct: 910 VIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGP 968
Score = 42.7 bits (96), Expect = 0.004
Identities = 29/81 (35%), Positives = 42/81 (51%), Gaps = 3/81 (3%)
Query: 13 VELTNDGNGLGFNLVGGR--STGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTS 70
VEL G GF+L GG+ + G+ I + G A KD R+ GD ++++ +G T
Sbjct: 1047 VELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITH 1106
Query: 71 EQVAAVLRQAGPVVRLLVARP 91
+ A L QAG LL+ RP
Sbjct: 1107 TR-AIELIQAGGNKVLLLLRP 1126
Score = 40.3 bits (90), Expect = 0.021
Identities = 17/64 (26%), Positives = 36/64 (56%)
Query: 405 VEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDR 464
+ GG+E +I + DGP G ++ GD+++E+N G+TH+ + +++ ++
Sbjct: 1060 LRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNK 1119
Query: 465 VRLV 468
V L+
Sbjct: 1120 VLLL 1123
Score = 39.5 bits (88), Expect = 0.037
Identities = 20/70 (28%), Positives = 39/70 (55%), Gaps = 2/70 (2%)
Query: 13 VELTNDGNGLGFNLVGGRST--GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTS 70
V L +G GF ++GG + I ++P G A+KD RL++ D ++ + + ++G +
Sbjct: 752 VFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSH 811
Query: 71 EQVAAVLRQA 80
+QV ++ A
Sbjct: 812 KQVLDLMTTA 821
Score = 31.9 bits (69), Expect = 7.4
Identities = 25/89 (28%), Positives = 40/89 (44%), Gaps = 6/89 (6%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGF 68
++ + L G GF + TG +K +L + LQ GD + ++ N++
Sbjct: 600 ELVTIPLIKGPKGFGF-AIADSPTGQKVKMILDSQWC---QGLQKGDIIKEIYHQNVQNL 655
Query: 69 TSEQVAAVLRQ--AGPVVRLLVARPADPA 95
T QV VL+Q G V LL+ R P+
Sbjct: 656 THLQVVEVLKQFPVGADVPLLILRGGPPS 684
Score = 31.5 bits (68), Expect = 9.7
Identities = 16/54 (29%), Positives = 29/54 (53%)
Query: 405 VEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNIL 458
V GG YI +++P G G L A DEL+ ++ + G +H +V++++
Sbjct: 765 VLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLM 818
>AL133517-8|CAI22553.1| 1481|Homo sapiens membrane associated
guanylate kinase, WW and PDZ domain containing 3
protein.
Length = 1481
Score = 59.7 bits (138), Expect = 3e-08
Identities = 63/247 (25%), Positives = 103/247 (41%), Gaps = 20/247 (8%)
Query: 412 RPHHY--IRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP--DRVRL 467
RP + +++VL DGP G + GD ++++N + G TH++VV + + +P V L
Sbjct: 429 RPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNL 488
Query: 468 VCARN--SIDSGPRPVVNLASDREGFEARKIISG-SLNNLTTLVKAQSDTSINTSSTATL 524
R D PVV++ + + + G + N N S TL
Sbjct: 489 TLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQDFKPGAMVLEQNGKSGHTL 548
Query: 525 TNHSEQSKKSRSLECVSGLAMWQSKEDIVM--LVKADQGLGFSILDYQDPVDPNGTVIVV 582
T S + VS + S+ ++V L+K +G GF+I D P +I+
Sbjct: 549 TGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAIAD--SPTGQKVKMILD 606
Query: 583 RSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGT-VKVGIARPLPP 641
G + GD + + ++QN T Q V+ LK P G V + I R PP
Sbjct: 607 SQWCQG--------LQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPP 658
Query: 642 QDSSKSK 648
+ +K
Sbjct: 659 SPTKTAK 665
Score = 58.0 bits (134), Expect = 1e-07
Identities = 49/214 (22%), Positives = 92/214 (42%), Gaps = 8/214 (3%)
Query: 415 HYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSI 474
H I V+ P G L GD + VN + L+H +V ++K V L
Sbjct: 880 HKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEE 939
Query: 475 DSGPRPVVNLASDREGFEARKIISGSLNNL---TTLVKAQSDTSINTSSTATLTNHSEQS 531
GP N A + R + N++ + ++ + ++TS + ++H +
Sbjct: 940 HHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLA 999
Query: 532 KKSRSLECVSGLAMWQSKEDI-VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGV 590
+ ++ V G Q+ V L + +G GFS+ + + N + ++R L G
Sbjct: 1000 QPDTAVISVVGSRHNQNLGCYPVELERGPRGFGFSL---RGGKEYNMGLFILR-LAEDGP 1055
Query: 591 AEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
A K+G I GD+++ +NG Q T +A++ ++
Sbjct: 1056 AIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQ 1089
Score = 53.2 bits (122), Expect = 3e-06
Identities = 62/227 (27%), Positives = 103/227 (45%), Gaps = 26/227 (11%)
Query: 432 LNAGDELLEVNEYRLHGLTHSEVVNILKQLP--DRVRLVCARNSIDSGPRPVVNLASDRE 489
L GD + E+ + LTH +VV +LKQ P V L+ R S P + +D+
Sbjct: 613 LQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPS-PTKTAKMKTDK- 670
Query: 490 GFEARKIISGSLNNLTTLVKAQSD--TSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQ 547
K +GSL + + SI S + L + SE KS++L
Sbjct: 671 -----KENAGSLEAINEPIPQPMPFPPSIIRSGSPKL-DPSEVYLKSKTLYEDKPP---N 721
Query: 548 SKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVN 607
+K+ V L K + G GF +L P D + I + +++P G AEK+G + D +M ++
Sbjct: 722 TKDLDVFLRKQESGFGFRVLGGDGP-DQS---IYIGAIIPLGAAEKDGRLRAADELMCID 777
Query: 608 GVSIQNATLDQAVQALKGAPR-GTVKVGIARPL------PPQDSSKS 647
G+ ++ + Q + + A R G V + + R + P DSS++
Sbjct: 778 GIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQA 824
Score = 47.6 bits (108), Expect = 1e-04
Identities = 25/80 (31%), Positives = 42/80 (52%)
Query: 547 QSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSV 606
Q D+V+ K ++G GF IL ++ P + ++ G A++ G++ GD + +V
Sbjct: 847 QEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAV 906
Query: 607 NGVSIQNATLDQAVQALKGA 626
NG SI + D VQ +K A
Sbjct: 907 NGQSIVELSHDNIVQLIKDA 926
Score = 47.2 bits (107), Expect = 2e-04
Identities = 59/275 (21%), Positives = 112/275 (40%), Gaps = 32/275 (11%)
Query: 11 EVVELTNDGNGLGFNLVGGRST---GVV---IKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
+VV + G GF ++ ++ GV+ I V+ G AD+ +L+ GDH+ V +
Sbjct: 851 DVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQS 910
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVPTKILADPELLDRHLI 124
+ + + + +++ AG V L V + P GT P L R
Sbjct: 911 IVELSHDNIVQLIKDAGVTVTLTVIAEEEH----HGPPSGT----NSARQSPALQHR--- 959
Query: 125 ETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQKIPDHPIVCDSVSPTIT 184
+ Q +++ I G E I V DH + + I+
Sbjct: 960 --------PMGQSQANH-IPGDRSALEGEI---GKDVSTSYRHSWSDHKHLAQPDTAVIS 1007
Query: 185 ITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKI 244
+ + V+L + G G ++ G KE G+F+ + E A + G+I +
Sbjct: 1008 VVGSRHNQNLGCYPVELERGPRGFGFSLRG---GKEYNMGLFILRLAEDGPAIKDGRIHV 1064
Query: 245 NDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
D+I+E++G ++ +++E+++ G V L+L
Sbjct: 1065 GDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLL 1099
Score = 45.2 bits (102), Expect = 7e-04
Identities = 21/59 (35%), Positives = 38/59 (64%), Gaps = 2/59 (3%)
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHL--VLERYLRGP 286
+IEGS A++ GK+K+ D I V+G S+ + S+ V+++++ G++V L + E GP
Sbjct: 885 VIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGP 943
Score = 42.7 bits (96), Expect = 0.004
Identities = 29/81 (35%), Positives = 42/81 (51%), Gaps = 3/81 (3%)
Query: 13 VELTNDGNGLGFNLVGGR--STGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTS 70
VEL G GF+L GG+ + G+ I + G A KD R+ GD ++++ +G T
Sbjct: 1022 VELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITH 1081
Query: 71 EQVAAVLRQAGPVVRLLVARP 91
+ A L QAG LL+ RP
Sbjct: 1082 TR-AIELIQAGGNKVLLLLRP 1101
Score = 40.3 bits (90), Expect = 0.021
Identities = 17/64 (26%), Positives = 36/64 (56%)
Query: 405 VEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDR 464
+ GG+E +I + DGP G ++ GD+++E+N G+TH+ + +++ ++
Sbjct: 1035 LRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNK 1094
Query: 465 VRLV 468
V L+
Sbjct: 1095 VLLL 1098
Score = 39.5 bits (88), Expect = 0.037
Identities = 20/70 (28%), Positives = 39/70 (55%), Gaps = 2/70 (2%)
Query: 13 VELTNDGNGLGFNLVGGRST--GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTS 70
V L +G GF ++GG + I ++P G A+KD RL++ D ++ + + ++G +
Sbjct: 727 VFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSH 786
Query: 71 EQVAAVLRQA 80
+QV ++ A
Sbjct: 787 KQVLDLMTTA 796
Score = 31.9 bits (69), Expect = 7.4
Identities = 25/89 (28%), Positives = 40/89 (44%), Gaps = 6/89 (6%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGF 68
++ + L G GF + TG +K +L + LQ GD + ++ N++
Sbjct: 575 ELVTIPLIKGPKGFGF-AIADSPTGQKVKMILDSQWC---QGLQKGDIIKEIYHQNVQNL 630
Query: 69 TSEQVAAVLRQ--AGPVVRLLVARPADPA 95
T QV VL+Q G V LL+ R P+
Sbjct: 631 THLQVVEVLKQFPVGADVPLLILRGGPPS 659
Score = 31.5 bits (68), Expect = 9.7
Identities = 16/54 (29%), Positives = 29/54 (53%)
Query: 405 VEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNIL 458
V GG YI +++P G G L A DEL+ ++ + G +H +V++++
Sbjct: 740 VLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLM 793
>AF213259-1|AAG43837.1| 1125|Homo sapiens membrane-associated
guanylate kinase-related MAGI-3 protein.
Length = 1125
Score = 59.7 bits (138), Expect = 3e-08
Identities = 63/247 (25%), Positives = 103/247 (41%), Gaps = 20/247 (8%)
Query: 412 RPHHY--IRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP--DRVRL 467
RP + +++VL DGP G + GD ++++N + G TH++VV + + +P V L
Sbjct: 429 RPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNL 488
Query: 468 VCARN--SIDSGPRPVVNLASDREGFEARKIISG-SLNNLTTLVKAQSDTSINTSSTATL 524
R D PVV++ + + + G + N N S TL
Sbjct: 489 TLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQDFKPGAMVLEQNGKSGHTL 548
Query: 525 TNHSEQSKKSRSLECVSGLAMWQSKEDIVM--LVKADQGLGFSILDYQDPVDPNGTVIVV 582
T S + VS + S+ ++V L+K +G GF+I D P +I+
Sbjct: 549 TGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAIAD--SPTGQKVKMILD 606
Query: 583 RSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGT-VKVGIARPLPP 641
G + GD + + ++QN T Q V+ LK P G V + I R PP
Sbjct: 607 SQWCQG--------LQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPP 658
Query: 642 QDSSKSK 648
+ +K
Sbjct: 659 SPTKTAK 665
Score = 57.2 bits (132), Expect = 2e-07
Identities = 49/214 (22%), Positives = 91/214 (42%), Gaps = 8/214 (3%)
Query: 415 HYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSI 474
H I V+ P G L GD + VN + L+H +V ++K V L
Sbjct: 880 HKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEE 939
Query: 475 DSGPRPVVNLASDREGFEARKIISGSLNNL---TTLVKAQSDTSINTSSTATLTNHSEQS 531
GP N A + R + N++ + ++ + ++TS + +H +
Sbjct: 940 HHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWPDHKHLA 999
Query: 532 KKSRSLECVSGLAMWQSKEDI-VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGV 590
+ ++ V G Q+ V L + +G GFS+ + + N + ++R L G
Sbjct: 1000 QPDTAVISVVGSRHNQNLGCYPVELERGPRGFGFSL---RGGKEYNMGLFILR-LAEDGP 1055
Query: 591 AEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
A K+G I GD+++ +NG Q T +A++ ++
Sbjct: 1056 AIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQ 1089
Score = 55.6 bits (128), Expect = 5e-07
Identities = 63/227 (27%), Positives = 103/227 (45%), Gaps = 26/227 (11%)
Query: 432 LNAGDELLEVNEYRLHGLTHSEVVNILKQLP--DRVRLVCARNSIDSGPRPVVNLASDRE 489
L GD + E+ + LTH +VV +LKQ P V L+ R S P + +D+
Sbjct: 613 LQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPS-PTKTAKMKTDK- 670
Query: 490 GFEARKIISGSLNNLTTLVKAQSD--TSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQ 547
K +GSL + + SI S + L + SE KS++L
Sbjct: 671 -----KENAGSLEAINEPIPQPMPFPPSIIRSGSPKL-DPSEVYLKSKTLYEDKPP---N 721
Query: 548 SKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVN 607
+K+ V L K + G GF +L P D + I + +++P G AEK+G + D +M V+
Sbjct: 722 TKDLDVFLRKQESGFGFRVLGGDGP-DQS---IYIGAIIPLGAAEKDGRLRAADELMCVD 777
Query: 608 GVSIQNATLDQAVQAL-KGAPRGTVKVGIARPL------PPQDSSKS 647
G+ ++ + Q + + AP G V + + R + P DSS++
Sbjct: 778 GIPVKGKSHKQVLDLMTTAAPNGHVLLTVRRKIFYGEKQPEDDSSQA 824
Score = 50.4 bits (115), Expect = 2e-05
Identities = 60/275 (21%), Positives = 113/275 (41%), Gaps = 32/275 (11%)
Query: 11 EVVELTNDGNGLGFNLVGGRST---GVV---IKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
+VV + G GF ++ ++ GV+ I V+ G AD+ +L+ GDH+ V +
Sbjct: 851 DVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQS 910
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVPTKILADPELLDRHLI 124
+ + + + +++ AG V L V + P GT P L R
Sbjct: 911 IVELSHDNIVQLIKDAGVTVTLTVIAEEEH----HGPPSGT----NSARQSPALQHR--- 959
Query: 125 ETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQKIPDHPIVCDSVSPTIT 184
+ Q +++ I G E I V PDH + + I+
Sbjct: 960 --------PMGQSQANH-IPGDRSALEGEI---GKDVSTSYRHSWPDHKHLAQPDTAVIS 1007
Query: 185 ITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKI 244
+ + V+L + G G ++ G KE G+F+ + E A + G+I +
Sbjct: 1008 VVGSRHNQNLGCYPVELERGPRGFGFSLRG---GKEYNMGLFILRLAEDGPAIKDGRIHV 1064
Query: 245 NDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
D+I+E++G ++ +++E+++ G V L+L
Sbjct: 1065 GDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLL 1099
Score = 47.6 bits (108), Expect = 1e-04
Identities = 25/80 (31%), Positives = 42/80 (52%)
Query: 547 QSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSV 606
Q D+V+ K ++G GF IL ++ P + ++ G A++ G++ GD + +V
Sbjct: 847 QEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAV 906
Query: 607 NGVSIQNATLDQAVQALKGA 626
NG SI + D VQ +K A
Sbjct: 907 NGQSIVELSHDNIVQLIKDA 926
Score = 45.2 bits (102), Expect = 7e-04
Identities = 21/59 (35%), Positives = 38/59 (64%), Gaps = 2/59 (3%)
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHL--VLERYLRGP 286
+IEGS A++ GK+K+ D I V+G S+ + S+ V+++++ G++V L + E GP
Sbjct: 885 VIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGP 943
Score = 42.7 bits (96), Expect = 0.004
Identities = 22/72 (30%), Positives = 40/72 (55%), Gaps = 2/72 (2%)
Query: 13 VELTNDGNGLGFNLVGGRST--GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTS 70
V L +G GF ++GG + I ++P G A+KD RL++ D ++ V + ++G +
Sbjct: 727 VFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCVDGIPVKGKSH 786
Query: 71 EQVAAVLRQAGP 82
+QV ++ A P
Sbjct: 787 KQVLDLMTTAAP 798
Score = 42.7 bits (96), Expect = 0.004
Identities = 29/81 (35%), Positives = 42/81 (51%), Gaps = 3/81 (3%)
Query: 13 VELTNDGNGLGFNLVGGR--STGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTS 70
VEL G GF+L GG+ + G+ I + G A KD R+ GD ++++ +G T
Sbjct: 1022 VELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITH 1081
Query: 71 EQVAAVLRQAGPVVRLLVARP 91
+ A L QAG LL+ RP
Sbjct: 1082 TR-AIELIQAGGNKVLLLLRP 1101
Score = 40.3 bits (90), Expect = 0.021
Identities = 17/64 (26%), Positives = 36/64 (56%)
Query: 405 VEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDR 464
+ GG+E +I + DGP G ++ GD+++E+N G+TH+ + +++ ++
Sbjct: 1035 LRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNK 1094
Query: 465 VRLV 468
V L+
Sbjct: 1095 VLLL 1098
Score = 32.3 bits (70), Expect = 5.6
Identities = 22/76 (28%), Positives = 37/76 (48%), Gaps = 1/76 (1%)
Query: 405 VEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNIL-KQLPD 463
V GG YI +++P G G L A DEL+ V+ + G +H +V++++ P+
Sbjct: 740 VLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCVDGIPVKGKSHKQVLDLMTTAAPN 799
Query: 464 RVRLVCARNSIDSGPR 479
L+ R I G +
Sbjct: 800 GHVLLTVRRKIFYGEK 815
Score = 31.9 bits (69), Expect = 7.4
Identities = 25/89 (28%), Positives = 40/89 (44%), Gaps = 6/89 (6%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGF 68
++ + L G GF + TG +K +L + LQ GD + ++ N++
Sbjct: 575 ELVTIPLIKGPKGFGF-AIADSPTGQKVKMILDSQWC---QGLQKGDIIKEIYHQNVQNL 630
Query: 69 TSEQVAAVLRQ--AGPVVRLLVARPADPA 95
T QV VL+Q G V LL+ R P+
Sbjct: 631 THLQVVEVLKQFPVGADVPLLILRGGPPS 659
>AB046854-1|BAB13460.1| 874|Homo sapiens KIAA1634 protein protein.
Length = 874
Score = 59.7 bits (138), Expect = 3e-08
Identities = 63/247 (25%), Positives = 103/247 (41%), Gaps = 20/247 (8%)
Query: 412 RPHHY--IRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP--DRVRL 467
RP + +++VL DGP G + GD ++++N + G TH++VV + + +P V L
Sbjct: 178 RPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNL 237
Query: 468 VCARN--SIDSGPRPVVNLASDREGFEARKIISG-SLNNLTTLVKAQSDTSINTSSTATL 524
R D PVV++ + + + G + N N S TL
Sbjct: 238 TLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQDFKPGAMVLEQNGKSGHTL 297
Query: 525 TNHSEQSKKSRSLECVSGLAMWQSKEDIVM--LVKADQGLGFSILDYQDPVDPNGTVIVV 582
T S + VS + S+ ++V L+K +G GF+I D P +I+
Sbjct: 298 TGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAIAD--SPTGQKVKMILD 355
Query: 583 RSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGT-VKVGIARPLPP 641
G + GD + + ++QN T Q V+ LK P G V + I R PP
Sbjct: 356 SQWCQG--------LQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPP 407
Query: 642 QDSSKSK 648
+ +K
Sbjct: 408 SPTKTAK 414
Score = 58.0 bits (134), Expect = 1e-07
Identities = 49/214 (22%), Positives = 92/214 (42%), Gaps = 8/214 (3%)
Query: 415 HYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSI 474
H I V+ P G L GD + VN + L+H +V ++K V L
Sbjct: 629 HKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEE 688
Query: 475 DSGPRPVVNLASDREGFEARKIISGSLNNL---TTLVKAQSDTSINTSSTATLTNHSEQS 531
GP N A + R + N++ + ++ + ++TS + ++H +
Sbjct: 689 HHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLA 748
Query: 532 KKSRSLECVSGLAMWQSKEDI-VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGV 590
+ ++ V G Q+ V L + +G GFS+ + + N + ++R L G
Sbjct: 749 QPDTAVISVVGSRHNQNLGCYPVELERGPRGFGFSL---RGGKEYNMGLFILR-LAEDGP 804
Query: 591 AEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
A K+G I GD+++ +NG Q T +A++ ++
Sbjct: 805 AIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQ 838
Score = 53.2 bits (122), Expect = 3e-06
Identities = 62/227 (27%), Positives = 103/227 (45%), Gaps = 26/227 (11%)
Query: 432 LNAGDELLEVNEYRLHGLTHSEVVNILKQLP--DRVRLVCARNSIDSGPRPVVNLASDRE 489
L GD + E+ + LTH +VV +LKQ P V L+ R S P + +D+
Sbjct: 362 LQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPS-PTKTAKMKTDK- 419
Query: 490 GFEARKIISGSLNNLTTLVKAQSD--TSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQ 547
K +GSL + + SI S + L + SE KS++L
Sbjct: 420 -----KENAGSLEAINEPIPQPMPFPPSIIRSGSPKL-DPSEVYLKSKTLYEDKPP---N 470
Query: 548 SKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVN 607
+K+ V L K + G GF +L P D + I + +++P G AEK+G + D +M ++
Sbjct: 471 TKDLDVFLRKQESGFGFRVLGGDGP-DQS---IYIGAIIPLGAAEKDGRLRAADELMCID 526
Query: 608 GVSIQNATLDQAVQALKGAPR-GTVKVGIARPL------PPQDSSKS 647
G+ ++ + Q + + A R G V + + R + P DSS++
Sbjct: 527 GIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQA 573
Score = 47.6 bits (108), Expect = 1e-04
Identities = 25/80 (31%), Positives = 42/80 (52%)
Query: 547 QSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSV 606
Q D+V+ K ++G GF IL ++ P + ++ G A++ G++ GD + +V
Sbjct: 596 QEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAV 655
Query: 607 NGVSIQNATLDQAVQALKGA 626
NG SI + D VQ +K A
Sbjct: 656 NGQSIVELSHDNIVQLIKDA 675
Score = 47.2 bits (107), Expect = 2e-04
Identities = 59/275 (21%), Positives = 112/275 (40%), Gaps = 32/275 (11%)
Query: 11 EVVELTNDGNGLGFNLVGGRST---GVV---IKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
+VV + G GF ++ ++ GV+ I V+ G AD+ +L+ GDH+ V +
Sbjct: 600 DVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQS 659
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVPTKILADPELLDRHLI 124
+ + + + +++ AG V L V + P GT P L R
Sbjct: 660 IVELSHDNIVQLIKDAGVTVTLTVIAEEEH----HGPPSGT----NSARQSPALQHR--- 708
Query: 125 ETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQKIPDHPIVCDSVSPTIT 184
+ Q +++ I G E I V DH + + I+
Sbjct: 709 --------PMGQSQANH-IPGDRSALEGEI---GKDVSTSYRHSWSDHKHLAQPDTAVIS 756
Query: 185 ITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKI 244
+ + V+L + G G ++ G KE G+F+ + E A + G+I +
Sbjct: 757 VVGSRHNQNLGCYPVELERGPRGFGFSLRG---GKEYNMGLFILRLAEDGPAIKDGRIHV 813
Query: 245 NDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
D+I+E++G ++ +++E+++ G V L+L
Sbjct: 814 GDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLL 848
Score = 45.2 bits (102), Expect = 7e-04
Identities = 21/59 (35%), Positives = 38/59 (64%), Gaps = 2/59 (3%)
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHL--VLERYLRGP 286
+IEGS A++ GK+K+ D I V+G S+ + S+ V+++++ G++V L + E GP
Sbjct: 634 VIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGP 692
Score = 42.7 bits (96), Expect = 0.004
Identities = 29/81 (35%), Positives = 42/81 (51%), Gaps = 3/81 (3%)
Query: 13 VELTNDGNGLGFNLVGGR--STGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTS 70
VEL G GF+L GG+ + G+ I + G A KD R+ GD ++++ +G T
Sbjct: 771 VELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITH 830
Query: 71 EQVAAVLRQAGPVVRLLVARP 91
+ A L QAG LL+ RP
Sbjct: 831 TR-AIELIQAGGNKVLLLLRP 850
Score = 40.3 bits (90), Expect = 0.021
Identities = 17/64 (26%), Positives = 36/64 (56%)
Query: 405 VEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDR 464
+ GG+E +I + DGP G ++ GD+++E+N G+TH+ + +++ ++
Sbjct: 784 LRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNK 843
Query: 465 VRLV 468
V L+
Sbjct: 844 VLLL 847
Score = 39.5 bits (88), Expect = 0.037
Identities = 20/70 (28%), Positives = 39/70 (55%), Gaps = 2/70 (2%)
Query: 13 VELTNDGNGLGFNLVGGRST--GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTS 70
V L +G GF ++GG + I ++P G A+KD RL++ D ++ + + ++G +
Sbjct: 476 VFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSH 535
Query: 71 EQVAAVLRQA 80
+QV ++ A
Sbjct: 536 KQVLDLMTTA 545
Score = 31.9 bits (69), Expect = 7.4
Identities = 25/89 (28%), Positives = 40/89 (44%), Gaps = 6/89 (6%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGF 68
++ + L G GF + TG +K +L + LQ GD + ++ N++
Sbjct: 324 ELVTIPLIKGPKGFGF-AIADSPTGQKVKMILDSQWC---QGLQKGDIIKEIYHQNVQNL 379
Query: 69 TSEQVAAVLRQ--AGPVVRLLVARPADPA 95
T QV VL+Q G V LL+ R P+
Sbjct: 380 THLQVVEVLKQFPVGADVPLLILRGGPPS 408
Score = 31.5 bits (68), Expect = 9.7
Identities = 16/54 (29%), Positives = 29/54 (53%)
Query: 405 VEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNIL 458
V GG YI +++P G G L A DEL+ ++ + G +H +V++++
Sbjct: 489 VLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLM 542
>AL590374-2|CAH70416.1| 199|Homo sapiens InaD-like (Drosophila)
protein.
Length = 199
Score = 59.3 bits (137), Expect = 4e-08
Identities = 33/91 (36%), Positives = 49/91 (53%), Gaps = 6/91 (6%)
Query: 383 EILVAEIKK-LEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEV 441
E+ + E++K GLG+SL G D R ++ + P+GP G + GDELLE+
Sbjct: 20 ELHIIELEKDKNGLGLSLAGNKD-----RSRMSIFVVGINPEGPAAADGRMRIGDELLEI 74
Query: 442 NEYRLHGLTHSEVVNILKQLPDRVRLVCARN 472
N L+G +H I+K P +V+LV RN
Sbjct: 75 NNQILYGRSHQNASAIIKTAPSKVKLVFIRN 105
Score = 51.2 bits (117), Expect = 1e-05
Identities = 30/108 (27%), Positives = 56/108 (51%), Gaps = 4/108 (3%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTGVVIKYVL---PGGVADKDRRLQSGDHVLQVGSVNL 65
++ ++EL D NGLG +L G + + +V+ P G A D R++ GD +L++ + L
Sbjct: 20 ELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQIL 79
Query: 66 RGFTSEQVAAVLRQAGPVVRLLVARPADPATALR-APQPGTALVPTKI 112
G + + +A+++ A V+L+ R D + P P + P+ I
Sbjct: 80 YGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSI 127
Score = 39.5 bits (88), Expect = 0.037
Identities = 25/87 (28%), Positives = 47/87 (54%), Gaps = 2/87 (2%)
Query: 195 EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGI 254
E+ ++L K+ GLG+++AG ++ +S IFV I A G+++I D ++E++
Sbjct: 20 ELHIIELEKDKNGLGLSLAGNK-DRSRMS-IFVVGINPEGPAAADGRMRIGDELLEINNQ 77
Query: 255 SLADKSNPQSVEILRNTGISVHLVLER 281
L +S+ + I++ V LV R
Sbjct: 78 ILYGRSHQNASAIIKTAPSKVKLVFIR 104
>AL353802-1|CAI22258.1| 199|Homo sapiens InaD-like (Drosophila)
protein.
Length = 199
Score = 59.3 bits (137), Expect = 4e-08
Identities = 33/91 (36%), Positives = 49/91 (53%), Gaps = 6/91 (6%)
Query: 383 EILVAEIKK-LEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEV 441
E+ + E++K GLG+SL G D R ++ + P+GP G + GDELLE+
Sbjct: 20 ELHIIELEKDKNGLGLSLAGNKD-----RSRMSIFVVGINPEGPAAADGRMRIGDELLEI 74
Query: 442 NEYRLHGLTHSEVVNILKQLPDRVRLVCARN 472
N L+G +H I+K P +V+LV RN
Sbjct: 75 NNQILYGRSHQNASAIIKTAPSKVKLVFIRN 105
Score = 51.2 bits (117), Expect = 1e-05
Identities = 30/108 (27%), Positives = 56/108 (51%), Gaps = 4/108 (3%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTGVVIKYVL---PGGVADKDRRLQSGDHVLQVGSVNL 65
++ ++EL D NGLG +L G + + +V+ P G A D R++ GD +L++ + L
Sbjct: 20 ELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQIL 79
Query: 66 RGFTSEQVAAVLRQAGPVVRLLVARPADPATALR-APQPGTALVPTKI 112
G + + +A+++ A V+L+ R D + P P + P+ I
Sbjct: 80 YGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSI 127
Score = 39.5 bits (88), Expect = 0.037
Identities = 25/87 (28%), Positives = 47/87 (54%), Gaps = 2/87 (2%)
Query: 195 EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGI 254
E+ ++L K+ GLG+++AG ++ +S IFV I A G+++I D ++E++
Sbjct: 20 ELHIIELEKDKNGLGLSLAGNK-DRSRMS-IFVVGINPEGPAAADGRMRIGDELLEINNQ 77
Query: 255 SLADKSNPQSVEILRNTGISVHLVLER 281
L +S+ + I++ V LV R
Sbjct: 78 ILYGRSHQNASAIIKTAPSKVKLVFIR 104
>AL136458-1|CAI21733.1| 199|Homo sapiens InaD-like (Drosophila)
protein.
Length = 199
Score = 59.3 bits (137), Expect = 4e-08
Identities = 33/91 (36%), Positives = 49/91 (53%), Gaps = 6/91 (6%)
Query: 383 EILVAEIKK-LEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEV 441
E+ + E++K GLG+SL G D R ++ + P+GP G + GDELLE+
Sbjct: 20 ELHIIELEKDKNGLGLSLAGNKD-----RSRMSIFVVGINPEGPAAADGRMRIGDELLEI 74
Query: 442 NEYRLHGLTHSEVVNILKQLPDRVRLVCARN 472
N L+G +H I+K P +V+LV RN
Sbjct: 75 NNQILYGRSHQNASAIIKTAPSKVKLVFIRN 105
Score = 51.2 bits (117), Expect = 1e-05
Identities = 30/108 (27%), Positives = 56/108 (51%), Gaps = 4/108 (3%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTGVVIKYVL---PGGVADKDRRLQSGDHVLQVGSVNL 65
++ ++EL D NGLG +L G + + +V+ P G A D R++ GD +L++ + L
Sbjct: 20 ELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQIL 79
Query: 66 RGFTSEQVAAVLRQAGPVVRLLVARPADPATALR-APQPGTALVPTKI 112
G + + +A+++ A V+L+ R D + P P + P+ I
Sbjct: 80 YGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSI 127
Score = 39.5 bits (88), Expect = 0.037
Identities = 25/87 (28%), Positives = 47/87 (54%), Gaps = 2/87 (2%)
Query: 195 EIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGI 254
E+ ++L K+ GLG+++AG ++ +S IFV I A G+++I D ++E++
Sbjct: 20 ELHIIELEKDKNGLGLSLAGNK-DRSRMS-IFVVGINPEGPAAADGRMRIGDELLEINNQ 77
Query: 255 SLADKSNPQSVEILRNTGISVHLVLER 281
L +S+ + I++ V LV R
Sbjct: 78 ILYGRSHQNASAIIKTAPSKVKLVFIR 104
>AL392123-9|CAI17335.1| 179|Homo sapiens par-3 partitioning
defective 3 homolog (C. elegans) protein.
Length = 179
Score = 58.8 bits (136), Expect = 6e-08
Identities = 28/66 (42%), Positives = 45/66 (68%), Gaps = 1/66 (1%)
Query: 207 GLGITVAGYVCEKEELS-GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSV 265
GLG++V G ++ GIFVKSII G +A + G++++ND++I V+G SL K+N ++
Sbjct: 38 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 97
Query: 266 EILRNT 271
E LR +
Sbjct: 98 ETLRRS 103
Score = 48.4 bits (110), Expect = 8e-05
Identities = 39/131 (29%), Positives = 63/131 (48%), Gaps = 16/131 (12%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 29 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 88
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 89 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 148
Query: 117 ELLDRHLIETG 127
E H + +G
Sbjct: 149 ERRISHSLYSG 159
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 38 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 97
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 98 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 133
>AF177228-1|AAG33676.1| 667|Homo sapiens CTCL tumor antigen se2-5
protein.
Length = 667
Score = 58.8 bits (136), Expect = 6e-08
Identities = 28/66 (42%), Positives = 45/66 (68%), Gaps = 1/66 (1%)
Query: 207 GLGITVAGYVCEKEELS-GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSV 265
GLG++V G ++ GIFVKSII G +A + G++++ND++I V+G SL K+N ++
Sbjct: 288 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 347
Query: 266 EILRNT 271
E LR +
Sbjct: 348 ETLRRS 353
Score = 51.2 bits (117), Expect = 1e-05
Identities = 25/75 (33%), Positives = 43/75 (57%)
Query: 197 IHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISL 256
+++ L K GL ++ + I+VK+I+ +A Q G++K DR+IEV+G+ L
Sbjct: 148 LNIQLKKGTEGLEFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDL 207
Query: 257 ADKSNPQSVEILRNT 271
KS + V +LR+T
Sbjct: 208 VGKSQEEVVSLLRST 222
Score = 49.2 bits (112), Expect = 5e-05
Identities = 36/114 (31%), Positives = 59/114 (51%), Gaps = 10/114 (8%)
Query: 13 VELTNDGNGLGFNLVG-----GRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GL F++ G S + +K +LP G A +D RL++GD +++V V+L G
Sbjct: 150 IQLKKGTEGLEFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 209
Query: 68 FTSEQVAAVLR--QAGPVVRLLVARPADP--ATALRAPQPGTALVPTKILADPE 117
+ E+V ++LR + V LLV R D L A +P +P + A+ E
Sbjct: 210 KSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNA-EPSQMQIPKETKAEDE 262
Score = 48.8 bits (111), Expect = 6e-05
Identities = 45/158 (28%), Positives = 75/158 (47%), Gaps = 17/158 (10%)
Query: 13 VELTNDGN-GLGFNLVGGRST------GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
V L + G+ GLG ++ G RS G+ +K ++ GG A KD RL+ D ++ V +L
Sbjct: 279 VPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESL 338
Query: 66 RGFTSEQVAAVLRQA-------GPVVRLLVARPADPATALRAP--QPGTALVPTKILADP 116
G T++ LR++ +++L+VAR L++P PG L L D
Sbjct: 339 LGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDDR 398
Query: 117 ELLDRHLIETGY-GAVYDLSQCYSDYNINGQNGETETS 153
E H + +G G S+ + I G++G+ + S
Sbjct: 399 ERRISHSLYSGIEGLDESPSRNAALSRIMGESGKYQLS 436
Score = 48.0 bits (109), Expect = 1e-04
Identities = 27/86 (31%), Positives = 46/86 (53%), Gaps = 2/86 (2%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
+ L K +GL FSI +D I V++++P G A ++G + GDR++ VNGV +
Sbjct: 150 IQLKKGTEGLEFSITS-RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 208
Query: 613 NATLDQAVQALKGAP-RGTVKVGIAR 637
+ ++ V L+ GTV + + R
Sbjct: 209 GKSQEEVVSLLRSTKMEGTVSLLVFR 234
Score = 46.8 bits (106), Expect = 2e-04
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 6/96 (6%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + + I V+S++ GG A K+G + D++++VNG S+ T A+
Sbjct: 288 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 347
Query: 621 QALK------GAPRGTVKVGIARPLPPQDSSKSKGT 650
+ L+ G RG +++ +AR + + KS G+
Sbjct: 348 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 383
Score = 41.1 bits (92), Expect = 0.012
Identities = 26/70 (37%), Positives = 36/70 (51%), Gaps = 3/70 (4%)
Query: 390 KKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
K EGL S+ GG Y++++LP G G L AGD L+EVN L G
Sbjct: 154 KGTEGLEFSITSRDVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 210
Query: 450 THSEVVNILK 459
+ EVV++L+
Sbjct: 211 SQEEVVSLLR 220
>AF257238-1|AAG24545.1| 1150|Homo sapiens membrane-associated
guanylate kinase MAGI3 protein.
Length = 1150
Score = 58.4 bits (135), Expect = 7e-08
Identities = 49/214 (22%), Positives = 93/214 (43%), Gaps = 8/214 (3%)
Query: 415 HYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSI 474
H I V+ P G L GD + VN + L+H+ +V ++K V L
Sbjct: 905 HKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHANIVQLIKDAGVTVTLTVIAEEE 964
Query: 475 DSGPRPVVNLASDREGFEARKIISGSLNNL---TTLVKAQSDTSINTSSTATLTNHSEQS 531
GP N A + R + N++ + ++ + ++TS + ++H +
Sbjct: 965 HHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLA 1024
Query: 532 KKSRSLECVSGLAMWQSKEDI-VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGV 590
+ ++ V G Q+ V L + +G GFS+ + + N + ++R L G
Sbjct: 1025 QPDTAVISVVGSRHNQNLGCYPVELERGPRGFGFSL---RGGKEYNMGLFILR-LAEDGP 1080
Query: 591 AEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
A K+G I GD+++ +NG Q T +A++ ++
Sbjct: 1081 AIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQ 1114
Score = 54.8 bits (126), Expect = 9e-07
Identities = 64/250 (25%), Positives = 110/250 (44%), Gaps = 26/250 (10%)
Query: 412 RPHHY--IRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP--DRVRL 467
RP + +++VL DGP G + GD ++++N + G TH++VV + + +P V L
Sbjct: 454 RPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVFGHTHADVVQMFQLVPVNQYVNL 513
Query: 468 VCARN--SIDSGPRPVVNLASDREGFEARKIISGS--LN----NLTTLVKAQSDTSINTS 519
R D PVV++ + + + G +N +V Q+ S +TS
Sbjct: 514 TLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQDFKPGAMVLEQNGKSGHTS 573
Query: 520 STATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTV 579
+ L S+ S++ S+ SG + Q + + L+K +G GF+I D P +
Sbjct: 574 TGDGLNGPSDASEQRVSM-ASSGSS--QPELVTIPLIKGPKGFGFAIAD--SPTGQKVKM 628
Query: 580 IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGT-VKVGIARP 638
I+ G + D + + ++QN T Q V+ LK P G V + I R
Sbjct: 629 ILDSQWCQG--------LQKEDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRG 680
Query: 639 LPPQDSSKSK 648
PP + +K
Sbjct: 681 GPPSTTKTAK 690
Score = 48.8 bits (111), Expect = 6e-05
Identities = 59/225 (26%), Positives = 99/225 (44%), Gaps = 22/225 (9%)
Query: 432 LNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGF 491
L D + E+ + LTH +VV +LKQ P V + GP A +
Sbjct: 638 LQKEDIIKEIYHQNVQNLTHLQVVEVLKQFP--VGADVPLLILRGGPPSTTKTAKMKTD- 694
Query: 492 EARKIISGSLNNLTTLVKAQSD--TSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSK 549
+K +GSL + + SI S + L + SE KS++L +K
Sbjct: 695 --KKENAGSLEAINEPIPQPMPFPPSIIRSGSPKL-DPSEVYLKSKTLYEDKPP---NTK 748
Query: 550 EDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGV 609
+ V L K + G GF +L P D + I + +++P G AEK+G + D +M ++G+
Sbjct: 749 DLDVFLRKQESGFGFRVLGGDGP-DQS---IYIGAIIPLGAAEKDGRLRAADELMCIDGI 804
Query: 610 SIQNATLDQAVQALKGAPR-GTVKVGIARPL------PPQDSSKS 647
++ + Q + + A R G V + + R + P DSS++
Sbjct: 805 PVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQA 849
Score = 46.0 bits (104), Expect = 4e-04
Identities = 59/275 (21%), Positives = 111/275 (40%), Gaps = 32/275 (11%)
Query: 11 EVVELTNDGNGLGFNLVGGRST---GVV---IKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
+VV + G GF ++ ++ GV+ I V+ G AD+ +L+ GDH+ V +
Sbjct: 876 DVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQS 935
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVPTKILADPELLDRHLI 124
+ + + +++ AG V L V + P GT P L R
Sbjct: 936 IVELSHANIVQLIKDAGVTVTLTVIAEEEH----HGPPSGT----NSARQSPALQHR--- 984
Query: 125 ETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQKIPDHPIVCDSVSPTIT 184
+ Q +++ I G E I V DH + + I+
Sbjct: 985 --------PMGQSQANH-IPGDRSALEGEI---GKDVSTSYRHSWSDHKHLAQPDTAVIS 1032
Query: 185 ITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKI 244
+ + V+L + G G ++ G KE G+F+ + E A + G+I +
Sbjct: 1033 VVGSRHNQNLGCYPVELERGPRGFGFSLRG---GKEYNMGLFILRLAEDGPAIKDGRIHV 1089
Query: 245 NDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
D+I+E++G ++ +++E+++ G V L+L
Sbjct: 1090 GDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLL 1124
Score = 45.2 bits (102), Expect = 7e-04
Identities = 21/59 (35%), Positives = 38/59 (64%), Gaps = 2/59 (3%)
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHL--VLERYLRGP 286
+IEGS A++ GK+K+ D I V+G S+ + S+ V+++++ G++V L + E GP
Sbjct: 910 VIEGSPADRCGKLKVGDHISAVNGQSIVELSHANIVQLIKDAGVTVTLTVIAEEEHHGP 968
Score = 44.4 bits (100), Expect = 0.001
Identities = 24/80 (30%), Positives = 41/80 (51%)
Query: 547 QSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSV 606
Q D+V+ K ++G GF IL ++ P + ++ G A++ G++ GD + +V
Sbjct: 872 QEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAV 931
Query: 607 NGVSIQNATLDQAVQALKGA 626
NG SI + VQ +K A
Sbjct: 932 NGQSIVELSHANIVQLIKDA 951
Score = 42.7 bits (96), Expect = 0.004
Identities = 29/81 (35%), Positives = 42/81 (51%), Gaps = 3/81 (3%)
Query: 13 VELTNDGNGLGFNLVGGR--STGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTS 70
VEL G GF+L GG+ + G+ I + G A KD R+ GD ++++ +G T
Sbjct: 1047 VELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITH 1106
Query: 71 EQVAAVLRQAGPVVRLLVARP 91
+ A L QAG LL+ RP
Sbjct: 1107 TR-AIELIQAGGNKVLLLLRP 1126
Score = 40.3 bits (90), Expect = 0.021
Identities = 17/64 (26%), Positives = 36/64 (56%)
Query: 405 VEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDR 464
+ GG+E +I + DGP G ++ GD+++E+N G+TH+ + +++ ++
Sbjct: 1060 LRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNK 1119
Query: 465 VRLV 468
V L+
Sbjct: 1120 VLLL 1123
Score = 39.5 bits (88), Expect = 0.037
Identities = 20/70 (28%), Positives = 39/70 (55%), Gaps = 2/70 (2%)
Query: 13 VELTNDGNGLGFNLVGGRST--GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTS 70
V L +G GF ++GG + I ++P G A+KD RL++ D ++ + + ++G +
Sbjct: 752 VFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSH 811
Query: 71 EQVAAVLRQA 80
+QV ++ A
Sbjct: 812 KQVLDLMTTA 821
Score = 31.5 bits (68), Expect = 9.7
Identities = 16/54 (29%), Positives = 29/54 (53%)
Query: 405 VEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNIL 458
V GG YI +++P G G L A DEL+ ++ + G +H +V++++
Sbjct: 765 VLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLM 818
>U68138-1|AAB07736.1| 321|Homo sapiens PSD-95 protein.
Length = 321
Score = 58.0 bits (134), Expect = 1e-07
Identities = 32/94 (34%), Positives = 48/94 (51%), Gaps = 7/94 (7%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRST-------GVVIKYVLPGGVADKDRRLQSGDHVLQVG 61
+ E + L +GLGF++ GG + I ++PGG A +D RL+ D +L V
Sbjct: 25 EYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVN 84
Query: 62 SVNLRGFTSEQVAAVLRQAGPVVRLLVARPADPA 95
V++R T L++AG +VRL V R PA
Sbjct: 85 EVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPA 118
Score = 54.8 bits (126), Expect = 9e-07
Identities = 32/92 (34%), Positives = 46/92 (50%), Gaps = 7/92 (7%)
Query: 9 QVEVVELTNDGNGLGFNLVGG-------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVG 61
+V ++L GLGF++ GG + + ++ GG A KD RLQ GD +L V
Sbjct: 120 KVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVN 179
Query: 62 SVNLRGFTSEQVAAVLRQAGPVVRLLVARPAD 93
SV L E A L+ VV L VA+P++
Sbjct: 180 SVGLEDVMHEDAVAALKNTYDVVYLKVAKPSN 211
Score = 53.6 bits (123), Expect = 2e-06
Identities = 30/89 (33%), Positives = 52/89 (58%), Gaps = 4/89 (4%)
Query: 192 PEIEIIHVDLNKNVYGLGITVAGYVCEKEELSG---IFVKSIIEGSSAEQSGKIKINDRI 248
P +++ + L K GLG ++AG V + + G I+V IIEG +A + G+++I D+I
Sbjct: 117 PAEKVMEIKLIKGPKGLGFSIAGGV-GNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKI 175
Query: 249 IEVDGISLADKSNPQSVEILRNTGISVHL 277
+ V+ + L D + +V L+NT V+L
Sbjct: 176 LAVNSVGLEDVMHEDAVAALKNTYDVVYL 204
Score = 53.6 bits (123), Expect = 2e-06
Identities = 29/87 (33%), Positives = 48/87 (55%), Gaps = 2/87 (2%)
Query: 553 VMLVKADQGLGFSILD-YQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSI 611
+ L+K +GLGFSI + P I V ++ GG A K+G + GD++++VN V +
Sbjct: 124 IKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGL 183
Query: 612 QNATLDQAVQALKGAPRGTVKVGIARP 638
++ + AV ALK V + +A+P
Sbjct: 184 EDVMHEDAVAALKNT-YDVVYLKVAKP 209
Score = 52.0 bits (119), Expect = 6e-06
Identities = 30/92 (32%), Positives = 49/92 (53%), Gaps = 2/92 (2%)
Query: 553 VMLVKADQGLGFSILDYQD-PVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSI 611
+ L + + GLGFSI D P + I + ++PGG A ++G + D ++ VN V +
Sbjct: 29 ITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDV 88
Query: 612 QNATLDQAVQALKGAPRGTVKVGIARPLPPQD 643
+ T AV+ALK A V++ + R PP +
Sbjct: 89 REVTHSAAVEALKEA-GSIVRLYVMRRKPPAE 119
Score = 50.0 bits (114), Expect = 3e-05
Identities = 27/91 (29%), Positives = 49/91 (53%), Gaps = 2/91 (2%)
Query: 193 EIEIIHVDLNKNVYGLGITVAGYVCEKE--ELSGIFVKSIIEGSSAEQSGKIKINDRIIE 250
E+E + L + GLG ++AG + IF+ II G +A Q G++++ND I+
Sbjct: 23 EMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILF 82
Query: 251 VDGISLADKSNPQSVEILRNTGISVHLVLER 281
V+ + + + ++ +VE L+ G V L + R
Sbjct: 83 VNEVDVREVTHSAAVEALKEAGSIVRLYVMR 113
Score = 44.0 bits (99), Expect = 0.002
Identities = 28/79 (35%), Positives = 37/79 (46%), Gaps = 3/79 (3%)
Query: 394 GLGISLEGTVDVEG-GQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHS 452
GLG S+ G D G + P +I ++P G G L D +L VNE + +THS
Sbjct: 37 GLGFSIAGGTDNPHIGDD--PSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHS 94
Query: 453 EVVNILKQLPDRVRLVCAR 471
V LK+ VRL R
Sbjct: 95 AAVEALKEAGSIVRLYVMR 113
Score = 34.7 bits (76), Expect = 1.0
Identities = 16/33 (48%), Positives = 21/33 (63%), Gaps = 1/33 (3%)
Query: 21 GLGFNLVGGR-STGVVIKYVLPGGVADKDRRLQ 52
GLGFN+VGG G+ I ++L GG AD L+
Sbjct: 285 GLGFNIVGGEDGEGIFISFILAGGPADLSGELR 317
>AF028825-1|AAB84250.1| 296|Homo sapiens Tax interaction protein 15
protein.
Length = 296
Score = 58.0 bits (134), Expect = 1e-07
Identities = 32/94 (34%), Positives = 48/94 (51%), Gaps = 7/94 (7%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRST-------GVVIKYVLPGGVADKDRRLQSGDHVLQVG 61
+ E + L +GLGF++ GG + I ++PGG A +D RL+ D +L V
Sbjct: 59 EYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVN 118
Query: 62 SVNLRGFTSEQVAAVLRQAGPVVRLLVARPADPA 95
V++R T L++AG +VRL V R PA
Sbjct: 119 EVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPA 152
Score = 56.0 bits (129), Expect = 4e-07
Identities = 40/122 (32%), Positives = 57/122 (46%), Gaps = 11/122 (9%)
Query: 9 QVEVVELTNDGNGLGFNLVGG-------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVG 61
+V ++L GLGF++ GG + + ++ GG A KD RLQ GD +L V
Sbjct: 154 KVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVN 213
Query: 62 SVNLRGFTSEQVAAVLRQAGPVVRLLVARPADP--ATALRAPQPGTALVP--TKILADPE 117
SV L E A L+ VV L VA+P++ + + P T P TK+ DP
Sbjct: 214 SVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTCESPSNTKVPHDPS 273
Query: 118 LL 119
L
Sbjct: 274 RL 275
Score = 53.6 bits (123), Expect = 2e-06
Identities = 30/89 (33%), Positives = 52/89 (58%), Gaps = 4/89 (4%)
Query: 192 PEIEIIHVDLNKNVYGLGITVAGYVCEKEELSG---IFVKSIIEGSSAEQSGKIKINDRI 248
P +++ + L K GLG ++AG V + + G I+V IIEG +A + G+++I D+I
Sbjct: 151 PAEKVMEIKLIKGPKGLGFSIAGGV-GNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKI 209
Query: 249 IEVDGISLADKSNPQSVEILRNTGISVHL 277
+ V+ + L D + +V L+NT V+L
Sbjct: 210 LAVNSVGLEDVMHEDAVAALKNTYDVVYL 238
Score = 53.6 bits (123), Expect = 2e-06
Identities = 29/87 (33%), Positives = 48/87 (55%), Gaps = 2/87 (2%)
Query: 553 VMLVKADQGLGFSILD-YQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSI 611
+ L+K +GLGFSI + P I V ++ GG A K+G + GD++++VN V +
Sbjct: 158 IKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGL 217
Query: 612 QNATLDQAVQALKGAPRGTVKVGIARP 638
++ + AV ALK V + +A+P
Sbjct: 218 EDVMHEDAVAALKNT-YDVVYLKVAKP 243
Score = 52.0 bits (119), Expect = 6e-06
Identities = 30/92 (32%), Positives = 49/92 (53%), Gaps = 2/92 (2%)
Query: 553 VMLVKADQGLGFSILDYQD-PVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSI 611
+ L + + GLGFSI D P + I + ++PGG A ++G + D ++ VN V +
Sbjct: 63 ITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDV 122
Query: 612 QNATLDQAVQALKGAPRGTVKVGIARPLPPQD 643
+ T AV+ALK A V++ + R PP +
Sbjct: 123 REVTHSAAVEALKEA-GSIVRLYVMRRKPPAE 153
Score = 50.0 bits (114), Expect = 3e-05
Identities = 27/91 (29%), Positives = 49/91 (53%), Gaps = 2/91 (2%)
Query: 193 EIEIIHVDLNKNVYGLGITVAGYVCEKE--ELSGIFVKSIIEGSSAEQSGKIKINDRIIE 250
E+E + L + GLG ++AG + IF+ II G +A Q G++++ND I+
Sbjct: 57 EMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILF 116
Query: 251 VDGISLADKSNPQSVEILRNTGISVHLVLER 281
V+ + + + ++ +VE L+ G V L + R
Sbjct: 117 VNEVDVREVTHSAAVEALKEAGSIVRLYVMR 147
Score = 44.0 bits (99), Expect = 0.002
Identities = 28/79 (35%), Positives = 37/79 (46%), Gaps = 3/79 (3%)
Query: 394 GLGISLEGTVDVEG-GQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHS 452
GLG S+ G D G + P +I ++P G G L D +L VNE + +THS
Sbjct: 71 GLGFSIAGGTDNPHIGDD--PSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHS 128
Query: 453 EVVNILKQLPDRVRLVCAR 471
V LK+ VRL R
Sbjct: 129 AAVEALKEAGSIVRLYVMR 147
>BC021135-1|AAH21135.1| 346|Homo sapiens INADL protein protein.
Length = 346
Score = 57.6 bits (133), Expect = 1e-07
Identities = 30/73 (41%), Positives = 45/73 (61%), Gaps = 1/73 (1%)
Query: 19 GNGLGFNLVGGRS-TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAVL 77
G GLG ++VG R+ +GV I ++ GG AD D RL GD +L V ++R + E VA +L
Sbjct: 86 GRGLGLSIVGKRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATIL 145
Query: 78 RQAGPVVRLLVAR 90
+ A +V+L + R
Sbjct: 146 KCAQGLVQLEIGR 158
Score = 51.6 bits (118), Expect = 9e-06
Identities = 29/81 (35%), Positives = 49/81 (60%), Gaps = 6/81 (7%)
Query: 557 KADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATL 616
KA +GLG SI+ + NG+ + + +V GG A+ +G + GD+++SVNG ++NA+
Sbjct: 84 KAGRGLGLSIVGKR-----NGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQ 138
Query: 617 DQAVQALKGAPRGTVKVGIAR 637
+ LK A +G V++ I R
Sbjct: 139 ETVATILKCA-QGLVQLEIGR 158
Score = 50.0 bits (114), Expect = 3e-05
Identities = 43/173 (24%), Positives = 75/173 (43%), Gaps = 13/173 (7%)
Query: 194 IEIIHVDLNKNV-YGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVD 252
+EI VDL K GLG+++ G K SG+F+ I++G +A+ G++ D+I+ V+
Sbjct: 74 LEIFPVDLQKKAGRGLGLSIVG----KRNGSGVFISDIVKGGAADLDGRLIQGDQILSVN 129
Query: 253 GISLADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHLQLAIFNEERXXXXXXXXXXLS 312
G + + S IL+ V L + R LR + + N + S
Sbjct: 130 GEDMRNASQETVATILKCAQGLVQLEIGR-LRAGSWTSARTTSQNSQGSQQSAHSSCHPS 188
Query: 313 WFPVPSQLENSITEIEPEPESNTTIDSSVLEVGDLQEPTQEELDQRFDEILAV 365
+ PV + L+N + + D S G EP E+++ + L +
Sbjct: 189 FAPVITGLQNLV-------GTKRVSDPSQKNSGTDMEPRTVEINRELSDALGI 234
Score = 46.4 bits (105), Expect = 3e-04
Identities = 23/56 (41%), Positives = 31/56 (55%)
Query: 417 IRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARN 472
I V +G G L AGD++LEVN L +H E + L+Q P +VRLV R+
Sbjct: 9 IHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRD 64
Score = 45.6 bits (103), Expect = 6e-04
Identities = 24/57 (42%), Positives = 33/57 (57%)
Query: 34 VVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVAR 90
+VI V G A +D RL +GD +L+V V+LR + E+ LRQ VRL+V R
Sbjct: 7 IVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYR 63
Score = 42.7 bits (96), Expect = 0.004
Identities = 16/49 (32%), Positives = 33/49 (67%)
Query: 580 IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPR 628
IV+ + G A ++G + GD+++ VNGV ++N++ ++A+ AL+ P+
Sbjct: 7 IVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQ 55
Score = 42.3 bits (95), Expect = 0.005
Identities = 19/60 (31%), Positives = 36/60 (60%)
Query: 222 LSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
L+ I + + E +A + G++ D+I+EV+G+ L + S+ +++ LR T V LV+ R
Sbjct: 4 LNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYR 63
Score = 39.1 bits (87), Expect = 0.049
Identities = 32/111 (28%), Positives = 52/111 (46%), Gaps = 6/111 (5%)
Query: 379 GSDKEILVAEIKK--LEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGD 436
G+D E EI + + LGIS+ G G +I + G L GD
Sbjct: 214 GTDMEPRTVEINRELSDALGISIAGG---RGSPLGDIPVFIAMIQASGVAARTQKLKVGD 270
Query: 437 ELLEVNEYRLHGLTHSEVVNILKQLPDRVRL-VCARNSIDSGPRPVVNLAS 486
++ +N L GL+H++VVN+LK R+ L V A +I + + N+++
Sbjct: 271 RIVSINGQPLDGLSHADVVNLLKNAYGRIILQVVADTNISAIAAQLENMST 321
Score = 37.1 bits (82), Expect = 0.20
Identities = 53/245 (21%), Positives = 94/245 (38%), Gaps = 25/245 (10%)
Query: 383 EILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVN 442
EI +++K G G+ L V G + +I ++ G L G L GD++L VN
Sbjct: 75 EIFPVDLQKKAGRGLGLS-IVGKRNGSGV----FISDIVKGGAADLDGRLIQGDQILSVN 129
Query: 443 EYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLN 502
+ + V ILK V+L R + +G S + S
Sbjct: 130 GEDMRNASQETVATILKCAQGLVQLEIGR--LRAGSWTSARTTSQNSQGSQQSAHSSCHP 187
Query: 503 NLTTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGL 562
+ ++ N T +++ S+++ SG M + + + L
Sbjct: 188 SFAPVITGLQ----NLVGTKRVSDPSQKN---------SGTDM--EPRTVEINRELSDAL 232
Query: 563 GFSILDYQDPVDPNGTV-IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQ 621
G SI + P G + + + + GVA + ++ GDR++S+NG + + V
Sbjct: 233 GISIAGGRG--SPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVN 290
Query: 622 ALKGA 626
LK A
Sbjct: 291 LLKNA 295
Score = 35.5 bits (78), Expect = 0.60
Identities = 21/73 (28%), Positives = 39/73 (53%), Gaps = 1/73 (1%)
Query: 199 VDLNKNVY-GLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLA 257
V++N+ + LGI++AG +F+ I A ++ K+K+ DRI+ ++G L
Sbjct: 222 VEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLD 281
Query: 258 DKSNPQSVEILRN 270
S+ V +L+N
Sbjct: 282 GLSHADVVNLLKN 294
Score = 34.7 bits (76), Expect = 1.0
Identities = 23/84 (27%), Positives = 43/84 (51%), Gaps = 7/84 (8%)
Query: 13 VELTND-GNGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLR 66
VE+ + + LG ++ GGR + V I + GVA + ++L+ GD ++ + L
Sbjct: 222 VEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLD 281
Query: 67 GFTSEQVAAVLRQA-GPVVRLLVA 89
G + V +L+ A G ++ +VA
Sbjct: 282 GLSHADVVNLLKNAYGRIILQVVA 305
>AL353639-5|CAI41240.1| 353|Homo sapiens multiple PDZ domain
protein protein.
Length = 353
Score = 56.4 bits (130), Expect = 3e-07
Identities = 41/114 (35%), Positives = 59/114 (51%), Gaps = 11/114 (9%)
Query: 365 VDKED-IVKKWK---EEIGS-DKEILVAEIKK-LEGLGISLEGTVDVEGGQELRPHHYIR 418
VDKED WK E G+ E+ + E++K GLG+SL G D R +I
Sbjct: 191 VDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGLGLSLAGNKD-----RSRMSVFIV 245
Query: 419 SVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARN 472
+ P+G G G L DELLE+N L+G +H +I+K P +V+++ RN
Sbjct: 246 GIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRN 299
Score = 50.0 bits (114), Expect = 3e-05
Identities = 28/104 (26%), Positives = 54/104 (51%), Gaps = 4/104 (3%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTGVVIKYVL---PGGVADKDRRLQSGDHVLQVGSVNL 65
++ ++EL +GLG +L G + + +++ P G A KD RLQ D +L++ L
Sbjct: 214 ELHMIELEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQIL 273
Query: 66 RGFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVP 109
G + + +++++ A V+++ R D + A PG A+ P
Sbjct: 274 YGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQM-AVCPGNAVEP 316
Score = 34.3 bits (75), Expect = 1.4
Identities = 14/31 (45%), Positives = 22/31 (70%)
Query: 220 EELSGIFVKSIIEGSSAEQSGKIKINDRIIE 250
E + GIF+K ++E S A ++G +K DRI+E
Sbjct: 117 EVMRGIFIKHVLEDSPAGKNGTLKPGDRIVE 147
Score = 33.9 bits (74), Expect = 1.8
Identities = 21/76 (27%), Positives = 36/76 (47%), Gaps = 3/76 (3%)
Query: 552 IVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSI 611
++ L K GLG S+ +D +V +V + P G A K+G + D ++ +NG +
Sbjct: 217 MIELEKGHSGLGLSLAGNKDR--SRMSVFIV-GIDPNGAAGKDGRLQIADELLEINGQIL 273
Query: 612 QNATLDQAVQALKGAP 627
+ A +K AP
Sbjct: 274 YGRSHQNASSIIKCAP 289
>AK057965-1|BAB71623.1| 624|Homo sapiens protein ( Homo sapiens
cDNA FLJ25236 fis, clone STM02096. ).
Length = 624
Score = 55.6 bits (128), Expect = 5e-07
Identities = 27/66 (40%), Positives = 45/66 (68%), Gaps = 1/66 (1%)
Query: 207 GLGITVAGYVCEKEELS-GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSV 265
GLG+++ G + GIF+KSII G +A + G++++ND++I V+G SL KSN +++
Sbjct: 231 GLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAM 290
Query: 266 EILRNT 271
E LR +
Sbjct: 291 ETLRRS 296
Score = 54.4 bits (125), Expect = 1e-06
Identities = 32/85 (37%), Positives = 49/85 (57%), Gaps = 7/85 (8%)
Query: 13 VELTNDGNGLGFNLVGGRST-----GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF +V S+ + +K +LP G A KD RLQSGD +L+V ++ G
Sbjct: 107 IDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTG 166
Query: 68 FTSEQVAAVLR--QAGPVVRLLVAR 90
T E++ A+LR + G L++AR
Sbjct: 167 RTQEELVAMLRSTKQGETASLVIAR 191
Score = 54.0 bits (124), Expect = 2e-06
Identities = 32/106 (30%), Positives = 57/106 (53%), Gaps = 3/106 (2%)
Query: 534 SRSLECVSGLAMWQSKEDI-VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAE 592
S SL + G ++ + I + L K +GLGF+++ + G + V ++++P G A
Sbjct: 87 SPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFV-KNILPKGAAI 145
Query: 593 KNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRG-TVKVGIAR 637
K+G + GDR++ VNG + T ++ V L+ +G T + IAR
Sbjct: 146 KDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIAR 191
Score = 50.0 bits (114), Expect = 3e-05
Identities = 30/87 (34%), Positives = 48/87 (55%), Gaps = 2/87 (2%)
Query: 197 IHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISL 256
I +DL K GLG TV IFVK+I+ +A + G+++ DRI+EV+G +
Sbjct: 105 IKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDV 164
Query: 257 ADKSNPQSVEILRNT--GISVHLVLER 281
++ + V +LR+T G + LV+ R
Sbjct: 165 TGRTQEELVAMLRSTKQGETASLVIAR 191
Score = 38.3 bits (85), Expect = 0.085
Identities = 26/99 (26%), Positives = 49/99 (49%), Gaps = 7/99 (7%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + I ++S++ GG A K+G + D++++VNG S+ + +A+
Sbjct: 231 GLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAM 290
Query: 621 QALK------GAPRGTVK-VGIARPLPPQDSSKSKGTIN 652
+ L+ G RG ++ V + RP P + G +
Sbjct: 291 ETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAECGAFS 329
Score = 37.1 bits (82), Expect = 0.20
Identities = 22/67 (32%), Positives = 36/67 (53%), Gaps = 2/67 (2%)
Query: 394 GLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSE 453
GLG+SL+G E G +L +I+S++ G G L D+L+ VN L G ++ E
Sbjct: 231 GLGVSLKGNKSRETGTDL--GIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHE 288
Query: 454 VVNILKQ 460
+ L++
Sbjct: 289 AMETLRR 295
Score = 36.7 bits (81), Expect = 0.26
Identities = 22/66 (33%), Positives = 34/66 (51%), Gaps = 2/66 (3%)
Query: 416 YIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP--DRVRLVCARNS 473
+++++LP G G L +GD +LEVN + G T E+V +L+ + LV AR
Sbjct: 134 FVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQE 193
Query: 474 IDSGPR 479
PR
Sbjct: 194 GHFLPR 199
>AF466152-1|AAL79827.1| 1136|Homo sapiens partitioning-defective
3-like protein splice variant c protein.
Length = 1136
Score = 55.6 bits (128), Expect = 5e-07
Identities = 27/66 (40%), Positives = 45/66 (68%), Gaps = 1/66 (1%)
Query: 207 GLGITVAGYVCEKEELS-GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSV 265
GLG+++ G + GIF+KSII G +A + G++++ND++I V+G SL KSN +++
Sbjct: 508 GLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAM 567
Query: 266 EILRNT 271
E LR +
Sbjct: 568 ETLRRS 573
Score = 54.4 bits (125), Expect = 1e-06
Identities = 32/85 (37%), Positives = 49/85 (57%), Gaps = 7/85 (8%)
Query: 13 VELTNDGNGLGFNLVGGRST-----GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF +V S+ + +K +LP G A KD RLQSGD +L+V ++ G
Sbjct: 384 IDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTG 443
Query: 68 FTSEQVAAVLR--QAGPVVRLLVAR 90
T E++ A+LR + G L++AR
Sbjct: 444 RTQEELVAMLRSTKQGETASLVIAR 468
Score = 54.0 bits (124), Expect = 2e-06
Identities = 32/106 (30%), Positives = 57/106 (53%), Gaps = 3/106 (2%)
Query: 534 SRSLECVSGLAMWQSKEDI-VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAE 592
S SL + G ++ + I + L K +GLGF+++ + G + V ++++P G A
Sbjct: 364 SPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFV-KNILPKGAAI 422
Query: 593 KNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRG-TVKVGIAR 637
K+G + GDR++ VNG + T ++ V L+ +G T + IAR
Sbjct: 423 KDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIAR 468
Score = 50.0 bits (114), Expect = 3e-05
Identities = 30/87 (34%), Positives = 48/87 (55%), Gaps = 2/87 (2%)
Query: 197 IHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISL 256
I +DL K GLG TV IFVK+I+ +A + G+++ DRI+EV+G +
Sbjct: 382 IKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDV 441
Query: 257 ADKSNPQSVEILRNT--GISVHLVLER 281
++ + V +LR+T G + LV+ R
Sbjct: 442 TGRTQEELVAMLRSTKQGETASLVIAR 468
Score = 38.3 bits (85), Expect = 0.085
Identities = 26/99 (26%), Positives = 49/99 (49%), Gaps = 7/99 (7%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + I ++S++ GG A K+G + D++++VNG S+ + +A+
Sbjct: 508 GLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAM 567
Query: 621 QALK------GAPRGTVK-VGIARPLPPQDSSKSKGTIN 652
+ L+ G RG ++ V + RP P + G +
Sbjct: 568 ETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAECGAFS 606
Score = 37.1 bits (82), Expect = 0.20
Identities = 22/67 (32%), Positives = 36/67 (53%), Gaps = 2/67 (2%)
Query: 394 GLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSE 453
GLG+SL+G E G +L +I+S++ G G L D+L+ VN L G ++ E
Sbjct: 508 GLGVSLKGNKSRETGTDL--GIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHE 565
Query: 454 VVNILKQ 460
+ L++
Sbjct: 566 AMETLRR 572
Score = 36.7 bits (81), Expect = 0.26
Identities = 22/66 (33%), Positives = 34/66 (51%), Gaps = 2/66 (3%)
Query: 416 YIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP--DRVRLVCARNS 473
+++++LP G G L +GD +LEVN + G T E+V +L+ + LV AR
Sbjct: 411 FVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQE 470
Query: 474 IDSGPR 479
PR
Sbjct: 471 GHFLPR 476
Score = 35.5 bits (78), Expect = 0.60
Identities = 24/120 (20%), Positives = 56/120 (46%), Gaps = 1/120 (0%)
Query: 161 VIGDNPQKIPDHPIVCDSVSPTITITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKE 220
V+ D+ Q + D ++ + +T + V+++ LGI V +
Sbjct: 166 VVPDSTQNLEDREVLNGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLS 225
Query: 221 -ELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
+ G+F++ I + S +++ G N+ I++++ + L DK+ Q+ ++ R S ++L
Sbjct: 226 GRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLL 285
>AF428250-1|AAL30664.1| 1205|Homo sapiens partitioning-defective
3-like protein splice variant a protein.
Length = 1205
Score = 55.6 bits (128), Expect = 5e-07
Identities = 27/66 (40%), Positives = 45/66 (68%), Gaps = 1/66 (1%)
Query: 207 GLGITVAGYVCEKEELS-GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSV 265
GLG+++ G + GIF+KSII G +A + G++++ND++I V+G SL KSN +++
Sbjct: 508 GLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAM 567
Query: 266 EILRNT 271
E LR +
Sbjct: 568 ETLRRS 573
Score = 54.4 bits (125), Expect = 1e-06
Identities = 32/85 (37%), Positives = 49/85 (57%), Gaps = 7/85 (8%)
Query: 13 VELTNDGNGLGFNLVGGRST-----GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF +V S+ + +K +LP G A KD RLQSGD +L+V ++ G
Sbjct: 384 IDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTG 443
Query: 68 FTSEQVAAVLR--QAGPVVRLLVAR 90
T E++ A+LR + G L++AR
Sbjct: 444 RTQEELVAMLRSTKQGETASLVIAR 468
Score = 54.0 bits (124), Expect = 2e-06
Identities = 32/106 (30%), Positives = 57/106 (53%), Gaps = 3/106 (2%)
Query: 534 SRSLECVSGLAMWQSKEDI-VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAE 592
S SL + G ++ + I + L K +GLGF+++ + G + V ++++P G A
Sbjct: 364 SPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFV-KNILPKGAAI 422
Query: 593 KNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRG-TVKVGIAR 637
K+G + GDR++ VNG + T ++ V L+ +G T + IAR
Sbjct: 423 KDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIAR 468
Score = 50.0 bits (114), Expect = 3e-05
Identities = 30/87 (34%), Positives = 48/87 (55%), Gaps = 2/87 (2%)
Query: 197 IHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISL 256
I +DL K GLG TV IFVK+I+ +A + G+++ DRI+EV+G +
Sbjct: 382 IKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDV 441
Query: 257 ADKSNPQSVEILRNT--GISVHLVLER 281
++ + V +LR+T G + LV+ R
Sbjct: 442 TGRTQEELVAMLRSTKQGETASLVIAR 468
Score = 38.3 bits (85), Expect = 0.085
Identities = 26/99 (26%), Positives = 49/99 (49%), Gaps = 7/99 (7%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + I ++S++ GG A K+G + D++++VNG S+ + +A+
Sbjct: 508 GLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAM 567
Query: 621 QALK------GAPRGTVK-VGIARPLPPQDSSKSKGTIN 652
+ L+ G RG ++ V + RP P + G +
Sbjct: 568 ETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAECGAFS 606
Score = 37.1 bits (82), Expect = 0.20
Identities = 22/67 (32%), Positives = 36/67 (53%), Gaps = 2/67 (2%)
Query: 394 GLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSE 453
GLG+SL+G E G +L +I+S++ G G L D+L+ VN L G ++ E
Sbjct: 508 GLGVSLKGNKSRETGTDL--GIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHE 565
Query: 454 VVNILKQ 460
+ L++
Sbjct: 566 AMETLRR 572
Score = 36.7 bits (81), Expect = 0.26
Identities = 22/66 (33%), Positives = 34/66 (51%), Gaps = 2/66 (3%)
Query: 416 YIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP--DRVRLVCARNS 473
+++++LP G G L +GD +LEVN + G T E+V +L+ + LV AR
Sbjct: 411 FVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQE 470
Query: 474 IDSGPR 479
PR
Sbjct: 471 GHFLPR 476
Score = 35.5 bits (78), Expect = 0.60
Identities = 24/120 (20%), Positives = 56/120 (46%), Gaps = 1/120 (0%)
Query: 161 VIGDNPQKIPDHPIVCDSVSPTITITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKE 220
V+ D+ Q + D ++ + +T + V+++ LGI V +
Sbjct: 166 VVPDSTQNLEDREVLNGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLS 225
Query: 221 -ELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
+ G+F++ I + S +++ G N+ I++++ + L DK+ Q+ ++ R S ++L
Sbjct: 226 GRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLL 285
>AB092439-1|BAC54285.1| 1205|Homo sapiens PAR3 beta alternatively
spliced form protein.
Length = 1205
Score = 55.6 bits (128), Expect = 5e-07
Identities = 27/66 (40%), Positives = 45/66 (68%), Gaps = 1/66 (1%)
Query: 207 GLGITVAGYVCEKEELS-GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSV 265
GLG+++ G + GIF+KSII G +A + G++++ND++I V+G SL KSN +++
Sbjct: 508 GLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAM 567
Query: 266 EILRNT 271
E LR +
Sbjct: 568 ETLRRS 573
Score = 54.4 bits (125), Expect = 1e-06
Identities = 32/85 (37%), Positives = 49/85 (57%), Gaps = 7/85 (8%)
Query: 13 VELTNDGNGLGFNLVGGRST-----GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF +V S+ + +K +LP G A KD RLQSGD +L+V ++ G
Sbjct: 384 IDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTG 443
Query: 68 FTSEQVAAVLR--QAGPVVRLLVAR 90
T E++ A+LR + G L++AR
Sbjct: 444 RTQEELVAMLRSTKQGETASLVIAR 468
Score = 54.0 bits (124), Expect = 2e-06
Identities = 32/106 (30%), Positives = 57/106 (53%), Gaps = 3/106 (2%)
Query: 534 SRSLECVSGLAMWQSKEDI-VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAE 592
S SL + G ++ + I + L K +GLGF+++ + G + V ++++P G A
Sbjct: 364 SPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFV-KNILPKGAAI 422
Query: 593 KNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRG-TVKVGIAR 637
K+G + GDR++ VNG + T ++ V L+ +G T + IAR
Sbjct: 423 KDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIAR 468
Score = 50.0 bits (114), Expect = 3e-05
Identities = 30/87 (34%), Positives = 48/87 (55%), Gaps = 2/87 (2%)
Query: 197 IHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISL 256
I +DL K GLG TV IFVK+I+ +A + G+++ DRI+EV+G +
Sbjct: 382 IKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDV 441
Query: 257 ADKSNPQSVEILRNT--GISVHLVLER 281
++ + V +LR+T G + LV+ R
Sbjct: 442 TGRTQEELVAMLRSTKQGETASLVIAR 468
Score = 38.3 bits (85), Expect = 0.085
Identities = 26/99 (26%), Positives = 49/99 (49%), Gaps = 7/99 (7%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + I ++S++ GG A K+G + D++++VNG S+ + +A+
Sbjct: 508 GLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAM 567
Query: 621 QALK------GAPRGTVK-VGIARPLPPQDSSKSKGTIN 652
+ L+ G RG ++ V + RP P + G +
Sbjct: 568 ETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAECGAFS 606
Score = 37.1 bits (82), Expect = 0.20
Identities = 22/67 (32%), Positives = 36/67 (53%), Gaps = 2/67 (2%)
Query: 394 GLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSE 453
GLG+SL+G E G +L +I+S++ G G L D+L+ VN L G ++ E
Sbjct: 508 GLGVSLKGNKSRETGTDL--GIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHE 565
Query: 454 VVNILKQ 460
+ L++
Sbjct: 566 AMETLRR 572
Score = 36.7 bits (81), Expect = 0.26
Identities = 22/66 (33%), Positives = 34/66 (51%), Gaps = 2/66 (3%)
Query: 416 YIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP--DRVRLVCARNS 473
+++++LP G G L +GD +LEVN + G T E+V +L+ + LV AR
Sbjct: 411 FVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQE 470
Query: 474 IDSGPR 479
PR
Sbjct: 471 GHFLPR 476
Score = 35.5 bits (78), Expect = 0.60
Identities = 24/120 (20%), Positives = 56/120 (46%), Gaps = 1/120 (0%)
Query: 161 VIGDNPQKIPDHPIVCDSVSPTITITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKE 220
V+ D+ Q + D ++ + +T + V+++ LGI V +
Sbjct: 166 VVPDSTQNLEDREVLNGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLS 225
Query: 221 -ELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
+ G+F++ I + S +++ G N+ I++++ + L DK+ Q+ ++ R S ++L
Sbjct: 226 GRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLL 285
>AB073472-1|BAC54035.1| 1104|Homo sapiens PAR3 beta protein.
Length = 1104
Score = 55.6 bits (128), Expect = 5e-07
Identities = 27/66 (40%), Positives = 45/66 (68%), Gaps = 1/66 (1%)
Query: 207 GLGITVAGYVCEKEELS-GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSV 265
GLG+++ G + GIF+KSII G +A + G++++ND++I V+G SL KSN +++
Sbjct: 508 GLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAM 567
Query: 266 EILRNT 271
E LR +
Sbjct: 568 ETLRRS 573
Score = 54.4 bits (125), Expect = 1e-06
Identities = 32/85 (37%), Positives = 49/85 (57%), Gaps = 7/85 (8%)
Query: 13 VELTNDGNGLGFNLVGGRST-----GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF +V S+ + +K +LP G A KD RLQSGD +L+V ++ G
Sbjct: 384 IDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTG 443
Query: 68 FTSEQVAAVLR--QAGPVVRLLVAR 90
T E++ A+LR + G L++AR
Sbjct: 444 RTQEELVAMLRSTKQGETASLVIAR 468
Score = 54.0 bits (124), Expect = 2e-06
Identities = 32/106 (30%), Positives = 57/106 (53%), Gaps = 3/106 (2%)
Query: 534 SRSLECVSGLAMWQSKEDI-VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAE 592
S SL + G ++ + I + L K +GLGF+++ + G + V ++++P G A
Sbjct: 364 SPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFV-KNILPKGAAI 422
Query: 593 KNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRG-TVKVGIAR 637
K+G + GDR++ VNG + T ++ V L+ +G T + IAR
Sbjct: 423 KDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIAR 468
Score = 50.0 bits (114), Expect = 3e-05
Identities = 30/87 (34%), Positives = 48/87 (55%), Gaps = 2/87 (2%)
Query: 197 IHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISL 256
I +DL K GLG TV IFVK+I+ +A + G+++ DRI+EV+G +
Sbjct: 382 IKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDV 441
Query: 257 ADKSNPQSVEILRNT--GISVHLVLER 281
++ + V +LR+T G + LV+ R
Sbjct: 442 TGRTQEELVAMLRSTKQGETASLVIAR 468
Score = 38.3 bits (85), Expect = 0.085
Identities = 26/99 (26%), Positives = 49/99 (49%), Gaps = 7/99 (7%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLG S+ + I ++S++ GG A K+G + D++++VNG S+ + +A+
Sbjct: 508 GLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAM 567
Query: 621 QALK------GAPRGTVK-VGIARPLPPQDSSKSKGTIN 652
+ L+ G RG ++ V + RP P + G +
Sbjct: 568 ETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAECGAFS 606
Score = 37.1 bits (82), Expect = 0.20
Identities = 22/67 (32%), Positives = 36/67 (53%), Gaps = 2/67 (2%)
Query: 394 GLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSE 453
GLG+SL+G E G +L +I+S++ G G L D+L+ VN L G ++ E
Sbjct: 508 GLGVSLKGNKSRETGTDL--GIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHE 565
Query: 454 VVNILKQ 460
+ L++
Sbjct: 566 AMETLRR 572
Score = 36.7 bits (81), Expect = 0.26
Identities = 22/66 (33%), Positives = 34/66 (51%), Gaps = 2/66 (3%)
Query: 416 YIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP--DRVRLVCARNS 473
+++++LP G G L +GD +LEVN + G T E+V +L+ + LV AR
Sbjct: 411 FVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQE 470
Query: 474 IDSGPR 479
PR
Sbjct: 471 GHFLPR 476
Score = 35.5 bits (78), Expect = 0.60
Identities = 24/120 (20%), Positives = 56/120 (46%), Gaps = 1/120 (0%)
Query: 161 VIGDNPQKIPDHPIVCDSVSPTITITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKE 220
V+ D+ Q + D ++ + +T + V+++ LGI V +
Sbjct: 166 VVPDSTQNLEDREVLNGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLS 225
Query: 221 -ELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
+ G+F++ I + S +++ G N+ I++++ + L DK+ Q+ ++ R S ++L
Sbjct: 226 GRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLL 285
>BC115394-1|AAI15395.1| 1076|Homo sapiens glutamate receptor
interacting protein 1 protein.
Length = 1076
Score = 54.8 bits (126), Expect = 9e-07
Identities = 72/277 (25%), Positives = 120/277 (43%), Gaps = 21/277 (7%)
Query: 205 VYGLGITVAGYVCEKEELSGIFVKSIIEGSS-AEQSGKIKINDRIIEVDGISLADKSNPQ 263
V G GI + G V E LS + S IE S AE+ G ++I DR++ ++GI D + +
Sbjct: 428 VTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEE 487
Query: 264 SVEILRNTGISVHLVLERYLRGPKFEHLQLAIFNEERXXXXXXXXXXLSWFPVPSQLENS 323
+ ++LR++ I+ + LE + F+ + P S+
Sbjct: 488 ASQLLRDSSITSKVTLEIEFDVAESVIPSSGTFHVKLPKKHNVELGITISSP-SSRKPGD 546
Query: 324 ITEIEPEPESNTTIDSSVLEVGD-LQEPTQEELD--QRFDEILAVDK-EDIVKK--WKEE 377
I + + + LE+GD L LD D + + + ED+VK K+E
Sbjct: 547 PLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIRKDE 606
Query: 378 IGSDKE------ILVAEIKKLEG-LGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQG 430
SD++ I E+K+ G LGI++ GT +E I S+ G G
Sbjct: 607 DNSDEQESSGAIIYTVELKRYGGPLGITISGT------EEPFDPIIISSLTKGGLAERTG 660
Query: 431 VLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRL 467
++ GD +L +N L G SE +++L+ + V L
Sbjct: 661 AIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTL 697
Score = 53.6 bits (123), Expect = 2e-06
Identities = 30/87 (34%), Positives = 49/87 (56%), Gaps = 5/87 (5%)
Query: 562 LGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQ 621
LG +I ++P DP I++ SL GG+AE+ G I GDR++++N S++ L +A+
Sbjct: 631 LGITISGTEEPFDP----IIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIH 686
Query: 622 ALKGAPRGTVKVGIARPLPPQDSSKSK 648
L+ A TV + I + Q +S K
Sbjct: 687 LLQMAGE-TVTLKIKKQTDAQSASSPK 712
Score = 52.8 bits (121), Expect = 4e-06
Identities = 30/82 (36%), Positives = 44/82 (53%), Gaps = 6/82 (7%)
Query: 13 VELTNDGNGLGFNLVGG------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLR 66
V L +GN GF + GG +S VVI V PGG AD++ ++ GD +L V + L
Sbjct: 153 VTLHKEGNTFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIRLL 212
Query: 67 GFTSEQVAAVLRQAGPVVRLLV 88
G T + ++L+Q G LL+
Sbjct: 213 GTTHAEAMSILKQCGQEAALLI 234
Score = 46.0 bits (104), Expect = 4e-04
Identities = 48/202 (23%), Positives = 86/202 (42%), Gaps = 8/202 (3%)
Query: 430 GVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRL-VCARNSIDSGPRPVVNLASDR 488
G L+ GD +L ++ + T +E L D+V+L + + + + A
Sbjct: 293 GALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQTRLALKGPDHAALVS 352
Query: 489 EGFEARKIISGSLN--NLTTLVKAQSDTSIN-TSSTATLTNHSEQSKKSRSLECVSGLAM 545
F + + SL+ N+ TL ++ TS T L +S S + V
Sbjct: 353 SSFSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFKSSLSLASSTVGLAGQ 412
Query: 546 WQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVI---VVRSLVPGGVAEKNGEISPGDR 602
E +++ AD GF I Q V T+ ++ + AE+ G + GDR
Sbjct: 413 VVHTETTEVVLTADPVTGFGI-QLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDR 471
Query: 603 VMSVNGVSIQNATLDQAVQALK 624
VM++NG+ +++T ++A Q L+
Sbjct: 472 VMAINGIPTEDSTFEEASQLLR 493
Score = 45.2 bits (102), Expect = 7e-04
Identities = 22/52 (42%), Positives = 29/52 (55%)
Query: 417 IRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLV 468
I V P GP +G + GD LL V+ RL G TH+E ++ILKQ L+
Sbjct: 182 ITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALL 233
Score = 44.0 bits (99), Expect = 0.002
Identities = 18/45 (40%), Positives = 30/45 (66%)
Query: 580 IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
+V+ + PGG A++ G I PGDR++SV+G+ + T +A+ LK
Sbjct: 180 VVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILK 224
Score = 43.6 bits (98), Expect = 0.002
Identities = 25/92 (27%), Positives = 44/92 (47%), Gaps = 2/92 (2%)
Query: 8 AQVEVVELTNDGNGLGFNLVGGRST--GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
A + VEL G LG + G ++I + GG+A++ + GD +L + S +L
Sbjct: 617 AIIYTVELKRYGGPLGITISGTEEPFDPIIISSLTKGGLAERTGAIHIGDRILAINSSSL 676
Query: 66 RGFTSEQVAAVLRQAGPVVRLLVARPADPATA 97
+G + +L+ AG V L + + D +A
Sbjct: 677 KGKPLSEAIHLLQMAGETVTLKIKKQTDAQSA 708
Score = 43.2 bits (97), Expect = 0.003
Identities = 28/113 (24%), Positives = 52/113 (46%), Gaps = 10/113 (8%)
Query: 178 SVSPTITITVPVELPEIEI---------IHVDLNKNVYGLGITVAGYVCEKEELSG-IFV 227
+V + + V ELP + + + V L+K G + G + S + +
Sbjct: 123 NVGERVVLEVEYELPPVSVQGSSVIFRTVEVTLHKEGNTFGFVIRGGAHDDRNKSRPVVI 182
Query: 228 KSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLE 280
+ G A++ G IK DR++ VDGI L ++ +++ IL+ G L++E
Sbjct: 183 TCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIE 235
Score = 42.7 bits (96), Expect = 0.004
Identities = 20/75 (26%), Positives = 40/75 (53%), Gaps = 1/75 (1%)
Query: 577 GTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIA 636
G +V+ + G VA + G + GD++++++ + + N +++ AVQ L+ VK+ I
Sbjct: 545 GDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQC-EDLVKLKIR 603
Query: 637 RPLPPQDSSKSKGTI 651
+ D +S G I
Sbjct: 604 KDEDNSDEQESSGAI 618
Score = 39.1 bits (87), Expect = 0.049
Identities = 33/110 (30%), Positives = 56/110 (50%), Gaps = 15/110 (13%)
Query: 360 DEILAVDKEDIVKKWKEEIGSDKEILVAEIKKLEG--LGISLEGTVDVEGGQELRPHHYI 417
D LAV ++ I +++K GS V E+ K EG LG+++ G +D +G +P +
Sbjct: 34 DGALAVRRQSIPEEFK---GST----VVELMKKEGTTLGLTVSGGIDKDG----KPR--V 80
Query: 418 RSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRL 467
++ G L+ GD + VN L H E++++LK + +RV L
Sbjct: 81 SNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVVL 130
Score = 39.1 bits (87), Expect = 0.049
Identities = 25/88 (28%), Positives = 43/88 (48%), Gaps = 3/88 (3%)
Query: 12 VVELTN-DGNGLGFNLVGG--RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGF 68
VVEL +G LG + GG + + + GG+A + +L GD++ V +NL F
Sbjct: 53 VVELMKKEGTTLGLTVSGGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAKF 112
Query: 69 TSEQVAAVLRQAGPVVRLLVARPADPAT 96
+++ ++L+ G V L V P +
Sbjct: 113 RHDEIISLLKNVGERVVLEVEYELPPVS 140
Score = 37.5 bits (83), Expect = 0.15
Identities = 26/95 (27%), Positives = 52/95 (54%), Gaps = 4/95 (4%)
Query: 186 TVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKIN 245
++P E ++ + + K LG+TV+G + +K+ V ++ +G A +S ++ +
Sbjct: 43 SIPEEFKGSTVVEL-MKKEGTTLGLTVSGGI-DKDGKPR--VSNLRQGGIAARSDQLDVG 98
Query: 246 DRIIEVDGISLADKSNPQSVEILRNTGISVHLVLE 280
D I V+GI+LA + + + +L+N G V L +E
Sbjct: 99 DYIKAVNGINLAKFRHDEIISLLKNVGERVVLEVE 133
Score = 37.5 bits (83), Expect = 0.15
Identities = 16/48 (33%), Positives = 29/48 (60%)
Query: 576 NGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQAL 623
N VIV+ + +A++ G + GD ++S++G S++ TL +A Q L
Sbjct: 274 NKQVIVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFL 321
Score = 35.1 bits (77), Expect = 0.79
Identities = 17/60 (28%), Positives = 32/60 (53%), Gaps = 1/60 (1%)
Query: 582 VRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPLPP 641
V +L GG+A ++ ++ GD + +VNG+++ D+ + LK V + + LPP
Sbjct: 80 VSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVV-LEVEYELPP 138
Score = 34.7 bits (76), Expect = 1.0
Identities = 20/61 (32%), Positives = 33/61 (54%), Gaps = 1/61 (1%)
Query: 416 YIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSID 475
Y++++ P GP L G L D LL+VN R VV ++ + +++ LV +RN +
Sbjct: 978 YVKNIRPAGPGDLGG-LKPYDRLLQVNHVRTRDFDCCLVVPLIAESGNKLDLVISRNPLA 1036
Query: 476 S 476
S
Sbjct: 1037 S 1037
>BC115393-1|AAI15394.1| 1076|Homo sapiens glutamate receptor
interacting protein 1 protein.
Length = 1076
Score = 54.8 bits (126), Expect = 9e-07
Identities = 72/277 (25%), Positives = 120/277 (43%), Gaps = 21/277 (7%)
Query: 205 VYGLGITVAGYVCEKEELSGIFVKSIIEGSS-AEQSGKIKINDRIIEVDGISLADKSNPQ 263
V G GI + G V E LS + S IE S AE+ G ++I DR++ ++GI D + +
Sbjct: 428 VTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEE 487
Query: 264 SVEILRNTGISVHLVLERYLRGPKFEHLQLAIFNEERXXXXXXXXXXLSWFPVPSQLENS 323
+ ++LR++ I+ + LE + F+ + P S+
Sbjct: 488 ASQLLRDSSITSKVTLEIEFDVAESVIPSSGTFHVKLPKKHNVELGITISSP-SSRKPGD 546
Query: 324 ITEIEPEPESNTTIDSSVLEVGD-LQEPTQEELD--QRFDEILAVDK-EDIVKK--WKEE 377
I + + + LE+GD L LD D + + + ED+VK K+E
Sbjct: 547 PLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIRKDE 606
Query: 378 IGSDKE------ILVAEIKKLEG-LGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQG 430
SD++ I E+K+ G LGI++ GT +E I S+ G G
Sbjct: 607 DNSDEQESSGAIIYTVELKRYGGPLGITISGT------EEPFDPIIISSLTKGGLAERTG 660
Query: 431 VLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRL 467
++ GD +L +N L G SE +++L+ + V L
Sbjct: 661 AIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTL 697
Score = 53.6 bits (123), Expect = 2e-06
Identities = 30/87 (34%), Positives = 49/87 (56%), Gaps = 5/87 (5%)
Query: 562 LGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQ 621
LG +I ++P DP I++ SL GG+AE+ G I GDR++++N S++ L +A+
Sbjct: 631 LGITISGTEEPFDP----IIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIH 686
Query: 622 ALKGAPRGTVKVGIARPLPPQDSSKSK 648
L+ A TV + I + Q +S K
Sbjct: 687 LLQMAGE-TVTLKIKKQTDAQSASSPK 712
Score = 52.8 bits (121), Expect = 4e-06
Identities = 30/82 (36%), Positives = 44/82 (53%), Gaps = 6/82 (7%)
Query: 13 VELTNDGNGLGFNLVGG------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLR 66
V L +GN GF + GG +S VVI V PGG AD++ ++ GD +L V + L
Sbjct: 153 VTLHKEGNTFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIRLL 212
Query: 67 GFTSEQVAAVLRQAGPVVRLLV 88
G T + ++L+Q G LL+
Sbjct: 213 GTTHAEAMSILKQCGQEAALLI 234
Score = 46.0 bits (104), Expect = 4e-04
Identities = 48/202 (23%), Positives = 86/202 (42%), Gaps = 8/202 (3%)
Query: 430 GVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRL-VCARNSIDSGPRPVVNLASDR 488
G L+ GD +L ++ + T +E L D+V+L + + + + A
Sbjct: 293 GALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQTRLALKGPDHAALVS 352
Query: 489 EGFEARKIISGSLN--NLTTLVKAQSDTSIN-TSSTATLTNHSEQSKKSRSLECVSGLAM 545
F + + SL+ N+ TL ++ TS T L +S S + V
Sbjct: 353 SSFSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFKSSLSLASSTVGLAGQ 412
Query: 546 WQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVI---VVRSLVPGGVAEKNGEISPGDR 602
E +++ AD GF I Q V T+ ++ + AE+ G + GDR
Sbjct: 413 VVHTETTEVVLTADPVTGFGI-QLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDR 471
Query: 603 VMSVNGVSIQNATLDQAVQALK 624
VM++NG+ +++T ++A Q L+
Sbjct: 472 VMAINGIPTEDSTFEEASQLLR 493
Score = 45.2 bits (102), Expect = 7e-04
Identities = 22/52 (42%), Positives = 29/52 (55%)
Query: 417 IRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLV 468
I V P GP +G + GD LL V+ RL G TH+E ++ILKQ L+
Sbjct: 182 ITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALL 233
Score = 44.0 bits (99), Expect = 0.002
Identities = 18/45 (40%), Positives = 30/45 (66%)
Query: 580 IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
+V+ + PGG A++ G I PGDR++SV+G+ + T +A+ LK
Sbjct: 180 VVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILK 224
Score = 43.6 bits (98), Expect = 0.002
Identities = 25/92 (27%), Positives = 44/92 (47%), Gaps = 2/92 (2%)
Query: 8 AQVEVVELTNDGNGLGFNLVGGRST--GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
A + VEL G LG + G ++I + GG+A++ + GD +L + S +L
Sbjct: 617 AIIYTVELKRYGGPLGITISGTEEPFDPIIISSLTKGGLAERTGAIHIGDRILAINSSSL 676
Query: 66 RGFTSEQVAAVLRQAGPVVRLLVARPADPATA 97
+G + +L+ AG V L + + D +A
Sbjct: 677 KGKPLSEAIHLLQMAGETVTLKIKKQTDAQSA 708
Score = 43.2 bits (97), Expect = 0.003
Identities = 28/113 (24%), Positives = 52/113 (46%), Gaps = 10/113 (8%)
Query: 178 SVSPTITITVPVELPEIEI---------IHVDLNKNVYGLGITVAGYVCEKEELSG-IFV 227
+V + + V ELP + + + V L+K G + G + S + +
Sbjct: 123 NVGERVVLEVEYELPPVSVQGSSVIFRTVEVTLHKEGNTFGFVIRGGAHDDRNKSRPVVI 182
Query: 228 KSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLE 280
+ G A++ G IK DR++ VDGI L ++ +++ IL+ G L++E
Sbjct: 183 TCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIE 235
Score = 42.7 bits (96), Expect = 0.004
Identities = 20/75 (26%), Positives = 40/75 (53%), Gaps = 1/75 (1%)
Query: 577 GTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIA 636
G +V+ + G VA + G + GD++++++ + + N +++ AVQ L+ VK+ I
Sbjct: 545 GDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQC-EDLVKLKIR 603
Query: 637 RPLPPQDSSKSKGTI 651
+ D +S G I
Sbjct: 604 KDEDNSDEQESSGAI 618
Score = 39.1 bits (87), Expect = 0.049
Identities = 33/110 (30%), Positives = 56/110 (50%), Gaps = 15/110 (13%)
Query: 360 DEILAVDKEDIVKKWKEEIGSDKEILVAEIKKLEG--LGISLEGTVDVEGGQELRPHHYI 417
D LAV ++ I +++K GS V E+ K EG LG+++ G +D +G +P +
Sbjct: 34 DGALAVRRQSIPEEFK---GST----VVELMKKEGTTLGLTVSGGIDKDG----KPR--V 80
Query: 418 RSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRL 467
++ G L+ GD + VN L H E++++LK + +RV L
Sbjct: 81 SNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVVL 130
Score = 39.1 bits (87), Expect = 0.049
Identities = 25/88 (28%), Positives = 43/88 (48%), Gaps = 3/88 (3%)
Query: 12 VVELTN-DGNGLGFNLVGG--RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGF 68
VVEL +G LG + GG + + + GG+A + +L GD++ V +NL F
Sbjct: 53 VVELMKKEGTTLGLTVSGGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAKF 112
Query: 69 TSEQVAAVLRQAGPVVRLLVARPADPAT 96
+++ ++L+ G V L V P +
Sbjct: 113 RHDEIISLLKNVGERVVLEVEYELPPVS 140
Score = 37.5 bits (83), Expect = 0.15
Identities = 26/95 (27%), Positives = 52/95 (54%), Gaps = 4/95 (4%)
Query: 186 TVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKIN 245
++P E ++ + + K LG+TV+G + +K+ V ++ +G A +S ++ +
Sbjct: 43 SIPEEFKGSTVVEL-MKKEGTTLGLTVSGGI-DKDGKPR--VSNLRQGGIAARSDQLDVG 98
Query: 246 DRIIEVDGISLADKSNPQSVEILRNTGISVHLVLE 280
D I V+GI+LA + + + +L+N G V L +E
Sbjct: 99 DYIKAVNGINLAKFRHDEIISLLKNVGERVVLEVE 133
Score = 37.5 bits (83), Expect = 0.15
Identities = 16/48 (33%), Positives = 29/48 (60%)
Query: 576 NGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQAL 623
N VIV+ + +A++ G + GD ++S++G S++ TL +A Q L
Sbjct: 274 NKQVIVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFL 321
Score = 35.1 bits (77), Expect = 0.79
Identities = 17/60 (28%), Positives = 32/60 (53%), Gaps = 1/60 (1%)
Query: 582 VRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPLPP 641
V +L GG+A ++ ++ GD + +VNG+++ D+ + LK V + + LPP
Sbjct: 80 VSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVV-LEVEYELPP 138
Score = 34.7 bits (76), Expect = 1.0
Identities = 20/61 (32%), Positives = 33/61 (54%), Gaps = 1/61 (1%)
Query: 416 YIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSID 475
Y++++ P GP L G L D LL+VN R VV ++ + +++ LV +RN +
Sbjct: 978 YVKNIRPAGPGDLGG-LKPYDRLLQVNHVRTRDFDCCLVVPLIAESGNKLDLVISRNPLA 1036
Query: 476 S 476
S
Sbjct: 1037 S 1037
>AJ133439-1|CAB39895.1| 849|Homo sapiens GRIP1 protein protein.
Length = 849
Score = 54.8 bits (126), Expect = 9e-07
Identities = 72/277 (25%), Positives = 120/277 (43%), Gaps = 21/277 (7%)
Query: 205 VYGLGITVAGYVCEKEELSGIFVKSIIEGSS-AEQSGKIKINDRIIEVDGISLADKSNPQ 263
V G GI + G V E LS + S IE S AE+ G ++I DR++ ++GI D + +
Sbjct: 216 VTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEE 275
Query: 264 SVEILRNTGISVHLVLERYLRGPKFEHLQLAIFNEERXXXXXXXXXXLSWFPVPSQLENS 323
+ ++LR++ I+ + LE + F+ + P S+
Sbjct: 276 ASQLLRDSSITSKVTLEIEFDVAESVIPSSGTFHVKLPKKHNVELGITISSP-SSRKPGD 334
Query: 324 ITEIEPEPESNTTIDSSVLEVGD-LQEPTQEELD--QRFDEILAVDK-EDIVKK--WKEE 377
I + + + LE+GD L LD D + + + ED+VK K+E
Sbjct: 335 PLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIRKDE 394
Query: 378 IGSDKE------ILVAEIKKLEG-LGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQG 430
SD++ I E+K+ G LGI++ GT +E I S+ G G
Sbjct: 395 DNSDEQESSGAIIYTVELKRYGGPLGITISGT------EEPFDPIIISSLTKGGLAERTG 448
Query: 431 VLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRL 467
++ GD +L +N L G SE +++L+ + V L
Sbjct: 449 AIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTL 485
Score = 53.6 bits (123), Expect = 2e-06
Identities = 30/87 (34%), Positives = 49/87 (56%), Gaps = 5/87 (5%)
Query: 562 LGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQ 621
LG +I ++P DP I++ SL GG+AE+ G I GDR++++N S++ L +A+
Sbjct: 419 LGITISGTEEPFDP----IIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIH 474
Query: 622 ALKGAPRGTVKVGIARPLPPQDSSKSK 648
L+ A TV + I + Q +S K
Sbjct: 475 LLQMAGE-TVTLKIKKQTDAQSASSPK 500
Score = 43.6 bits (98), Expect = 0.002
Identities = 25/92 (27%), Positives = 44/92 (47%), Gaps = 2/92 (2%)
Query: 8 AQVEVVELTNDGNGLGFNLVGGRST--GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
A + VEL G LG + G ++I + GG+A++ + GD +L + S +L
Sbjct: 405 AIIYTVELKRYGGPLGITISGTEEPFDPIIISSLTKGGLAERTGAIHIGDRILAINSSSL 464
Query: 66 RGFTSEQVAAVLRQAGPVVRLLVARPADPATA 97
+G + +L+ AG V L + + D +A
Sbjct: 465 KGKPLSEAIHLLQMAGETVTLKIKKQTDAQSA 496
Score = 42.7 bits (96), Expect = 0.004
Identities = 20/75 (26%), Positives = 40/75 (53%), Gaps = 1/75 (1%)
Query: 577 GTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIA 636
G +V+ + G VA + G + GD++++++ + + N +++ AVQ L+ VK+ I
Sbjct: 333 GDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQC-EDLVKLKIR 391
Query: 637 RPLPPQDSSKSKGTI 651
+ D +S G I
Sbjct: 392 KDEDNSDEQESSGAI 406
Score = 37.5 bits (83), Expect = 0.15
Identities = 16/48 (33%), Positives = 29/48 (60%)
Query: 576 NGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQAL 623
N VIV+ + +A++ G + GD ++S++G S++ TL +A Q L
Sbjct: 10 NKQVIVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFL 57
Score = 37.1 bits (82), Expect = 0.20
Identities = 54/222 (24%), Positives = 90/222 (40%), Gaps = 14/222 (6%)
Query: 410 ELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRL-HGLTHSEVVNILKQLPDRVRLV 468
E+ PHH R L GP ++ + D L + + H H+ + PD R+
Sbjct: 67 EILPHHQTRLALK-GPDHVK--IQRSDRQLTWDSWASNHSSLHTNH-HYNTYHPDHCRVP 122
Query: 469 CARNSIDSGPRPVVNLASDREGFEARKIISGSLN--NLTTLVKAQSDTSIN-TSSTATLT 525
+ P P A F + + SL+ N+ TL ++ TS T L
Sbjct: 123 AL--TFPKAPPPNSPPALVSSSFSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLK 180
Query: 526 NHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVI---VV 582
+S S + V E +++ AD GF I Q V T+ ++
Sbjct: 181 KKDFKSSLSLASSTVGLAGQVVHTETTEVVLTADPVTGFGI-QLQGSVFATETLSSPPLI 239
Query: 583 RSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
+ AE+ G + GDRVM++NG+ +++T ++A Q L+
Sbjct: 240 SYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQLLR 281
Score = 34.7 bits (76), Expect = 1.0
Identities = 20/61 (32%), Positives = 33/61 (54%), Gaps = 1/61 (1%)
Query: 416 YIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSID 475
Y++++ P GP L G L D LL+VN R VV ++ + +++ LV +RN +
Sbjct: 751 YVKNIRPAGPGDLGG-LKPYDRLLQVNHVRTRDFDCCLVVPLIAESGNKLDLVISRNPLA 809
Query: 476 S 476
S
Sbjct: 810 S 810
>BC015560-1|AAH15560.1| 320|Homo sapiens DLG1 protein protein.
Length = 320
Score = 54.4 bits (125), Expect = 1e-06
Identities = 29/89 (32%), Positives = 48/89 (53%), Gaps = 7/89 (7%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRS-------TGVVIKYVLPGGVADKDRRLQSGDHVLQVG 61
+ E + L +GLGF++ GG + + I ++ GG A +D RL+ D +L+V
Sbjct: 221 EYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVN 280
Query: 62 SVNLRGFTSEQVAAVLRQAGPVVRLLVAR 90
V++R T + L++AG +VRL V R
Sbjct: 281 EVDVRDVTHSKAVEALKEAGSIVRLYVKR 309
Score = 54.0 bits (124), Expect = 2e-06
Identities = 28/91 (30%), Positives = 51/91 (56%), Gaps = 2/91 (2%)
Query: 193 EIEIIHVDLNKNVYGLGITVAGYVCEKE--ELSGIFVKSIIEGSSAEQSGKIKINDRIIE 250
+ E + L + GLG ++AG + S IF+ II G +A Q G++++ND I+
Sbjct: 219 DYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILR 278
Query: 251 VDGISLADKSNPQSVEILRNTGISVHLVLER 281
V+ + + D ++ ++VE L+ G V L ++R
Sbjct: 279 VNEVDVRDVTHSKAVEALKEAGSIVRLYVKR 309
Score = 51.2 bits (117), Expect = 1e-05
Identities = 30/97 (30%), Positives = 52/97 (53%), Gaps = 2/97 (2%)
Query: 553 VMLVKADQGLGFSILDYQD-PVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSI 611
+ L + + GLGFSI D P + + I + ++ GG A ++G + D ++ VN V +
Sbjct: 225 ITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDV 284
Query: 612 QNATLDQAVQALKGAPRGTVKVGIARPLPPQDSSKSK 648
++ T +AV+ALK A V++ + R P + K K
Sbjct: 285 RDVTHSKAVEALKEA-GSIVRLYVKRRKPVSEKKKKK 320
Score = 38.3 bits (85), Expect = 0.085
Identities = 26/79 (32%), Positives = 36/79 (45%), Gaps = 3/79 (3%)
Query: 394 GLGISLEGTVDVEG-GQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHS 452
GLG S+ G D G + +I ++ G G L D +L VNE + +THS
Sbjct: 233 GLGFSIAGGTDNPHIGDD--SSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHS 290
Query: 453 EVVNILKQLPDRVRLVCAR 471
+ V LK+ VRL R
Sbjct: 291 KAVEALKEAGSIVRLYVKR 309
>AL161449-7|CAI40494.1| 335|Homo sapiens multiple PDZ domain
protein protein.
Length = 335
Score = 54.4 bits (125), Expect = 1e-06
Identities = 32/81 (39%), Positives = 44/81 (54%), Gaps = 1/81 (1%)
Query: 22 LGFNLVGGRSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAVLRQAG 81
L F +V TGV + ++ GG+AD D RL GD +L V ++R T E VAA+L+ +
Sbjct: 2 LKFKIVCRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKCSL 61
Query: 82 PVVRLLVAR-PADPATALRAP 101
V L V R A P + R P
Sbjct: 62 GTVTLEVGRIKAGPFHSERRP 82
Score = 52.4 bits (120), Expect = 5e-06
Identities = 28/85 (32%), Positives = 46/85 (54%), Gaps = 5/85 (5%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDHVLQVGSV 63
Q + + L +GLGF++VGG + + +K V G A +D RL+ GD ++ V
Sbjct: 249 QCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQ 308
Query: 64 NLRGFTSEQVAAVLRQAGPVVRLLV 88
+L G T E+ A+L++ V L+V
Sbjct: 309 SLEGVTHEEAVAILKRTKGTVTLMV 333
Score = 52.0 bits (119), Expect = 6e-06
Identities = 43/170 (25%), Positives = 82/170 (48%), Gaps = 17/170 (10%)
Query: 463 DRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTSSTA 522
DR+ +C ++ VNL + G ++++G +++ + Q + + ++ S
Sbjct: 176 DRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGG--DVSVVTGHQQEPASSSLSFT 233
Query: 523 TLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTV-IV 581
LT+ S +C S + L + GLGFSI+ P+G + I
Sbjct: 234 GLTSSSIFQDDLGPPQCKS-----------ITLERGPDGLGFSIVGGYG--SPHGDLPIY 280
Query: 582 VRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTV 631
V+++ G A ++G + GD++++VNG S++ T ++AV LK +GTV
Sbjct: 281 VKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILK-RTKGTV 329
Score = 50.4 bits (115), Expect = 2e-05
Identities = 57/221 (25%), Positives = 95/221 (42%), Gaps = 27/221 (12%)
Query: 416 YIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSID 475
++ ++ G G L GD++L VN + T V +LK V L R I
Sbjct: 15 FVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKCSLGTVTLEVGR--IK 72
Query: 476 SGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTSSTATLTNHSEQSKKSR 535
+GP S+R ++ ++ GSL++ T S ++T + SKK+
Sbjct: 73 AGP-----FHSERRPSQSSQVSEGSLSSFT----------FPLSGSSTSESLESSSKKNA 117
Query: 536 SLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTV-IVVRSLVPGGVAEKN 594
+ GL + K+ LG SI P G V I + + P GVA +
Sbjct: 118 LASEIQGLRTVEMKKG------PTDSLGISIAGGVG--SPLGDVPIFIAMMHPTGVAAQT 169
Query: 595 GEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGI 635
++ GDR++++ G S + T QAV LK A G++++ +
Sbjct: 170 QKLRVGDRIVTICGTSTEGMTHTQAVNLLKNA-SGSIEMQV 209
Score = 50.0 bits (114), Expect = 3e-05
Identities = 24/62 (38%), Positives = 38/62 (61%), Gaps = 1/62 (1%)
Query: 576 NGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGI 635
N T + V +V GG+A+ +G + GD+++ VNG ++NAT +AV AL GTV + +
Sbjct: 10 NDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNAT-QEAVAALLKCSLGTVTLEV 68
Query: 636 AR 637
R
Sbjct: 69 GR 70
Score = 46.4 bits (105), Expect = 3e-04
Identities = 35/138 (25%), Positives = 69/138 (50%), Gaps = 3/138 (2%)
Query: 143 INGQNGETETSIVAAA-VSVIGDNPQKIPDHPIVCDSVSPTITITVPVELPEIEIIHVDL 201
+ +G E +VA VSV+ + Q+ + ++ + + P+ + I ++
Sbjct: 198 LKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKSITLER 257
Query: 202 NKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSN 261
+ G I V GY +L I+VK++ +A + G++K D+II V+G SL ++
Sbjct: 258 GPDGLGFSI-VGGYGSPHGDLP-IYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTH 315
Query: 262 PQSVEILRNTGISVHLVL 279
++V IL+ T +V L++
Sbjct: 316 EEAVAILKRTKGTVTLMV 333
Score = 43.6 bits (98), Expect = 0.002
Identities = 27/76 (35%), Positives = 38/76 (50%), Gaps = 3/76 (3%)
Query: 393 EGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHS 452
+GLG S+ G G P Y+++V G G L GD+++ VN L G+TH
Sbjct: 260 DGLGFSIVGGYGSPHGD--LPI-YVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHE 316
Query: 453 EVVNILKQLPDRVRLV 468
E V ILK+ V L+
Sbjct: 317 EAVAILKRTKGTVTLM 332
Score = 39.1 bits (87), Expect = 0.049
Identities = 21/70 (30%), Positives = 38/70 (54%)
Query: 208 LGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEI 267
LGI++AG V IF+ + A Q+ K+++ DRI+ + G S ++ Q+V +
Sbjct: 138 LGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNL 197
Query: 268 LRNTGISVHL 277
L+N S+ +
Sbjct: 198 LKNASGSIEM 207
Score = 34.7 bits (76), Expect = 1.0
Identities = 19/71 (26%), Positives = 38/71 (53%), Gaps = 2/71 (2%)
Query: 216 VCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISV 275
VC + +G+FV I++G A+ G++ D+I+ V+G + + + +L+ + +V
Sbjct: 7 VCRND--TGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKCSLGTV 64
Query: 276 HLVLERYLRGP 286
L + R GP
Sbjct: 65 TLEVGRIKAGP 75
Score = 33.9 bits (74), Expect = 1.8
Identities = 23/97 (23%), Positives = 45/97 (46%), Gaps = 6/97 (6%)
Query: 3 LSTEWAQVEVVELTNDG-NGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDH 56
L++E + VE+ + LG ++ GG + + I + P GVA + ++L+ GD
Sbjct: 118 LASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDR 177
Query: 57 VLQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVARPAD 93
++ + + G T Q +L+ A + + V D
Sbjct: 178 IVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGD 214
>AK056157-1|BAB71106.1| 545|Homo sapiens protein ( Homo sapiens
cDNA FLJ31595 fis, clone NT2RI2002517, weakly similar to
Homo sapiens PAR3 mRNA. ).
Length = 545
Score = 54.4 bits (125), Expect = 1e-06
Identities = 32/85 (37%), Positives = 49/85 (57%), Gaps = 7/85 (8%)
Query: 13 VELTNDGNGLGFNLVGGRST-----GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF +V S+ + +K +LP G A KD RLQSGD +L+V ++ G
Sbjct: 384 IDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTG 443
Query: 68 FTSEQVAAVLR--QAGPVVRLLVAR 90
T E++ A+LR + G L++AR
Sbjct: 444 RTQEELVAMLRSTKQGETASLVIAR 468
Score = 54.0 bits (124), Expect = 2e-06
Identities = 32/106 (30%), Positives = 57/106 (53%), Gaps = 3/106 (2%)
Query: 534 SRSLECVSGLAMWQSKEDI-VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAE 592
S SL + G ++ + I + L K +GLGF+++ + G + V ++++P G A
Sbjct: 364 SPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFV-KNILPKGAAI 422
Query: 593 KNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRG-TVKVGIAR 637
K+G + GDR++ VNG + T ++ V L+ +G T + IAR
Sbjct: 423 KDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIAR 468
Score = 50.0 bits (114), Expect = 3e-05
Identities = 30/87 (34%), Positives = 48/87 (55%), Gaps = 2/87 (2%)
Query: 197 IHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISL 256
I +DL K GLG TV IFVK+I+ +A + G+++ DRI+EV+G +
Sbjct: 382 IKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDV 441
Query: 257 ADKSNPQSVEILRNT--GISVHLVLER 281
++ + V +LR+T G + LV+ R
Sbjct: 442 TGRTQEELVAMLRSTKQGETASLVIAR 468
Score = 36.7 bits (81), Expect = 0.26
Identities = 22/66 (33%), Positives = 34/66 (51%), Gaps = 2/66 (3%)
Query: 416 YIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP--DRVRLVCARNS 473
+++++LP G G L +GD +LEVN + G T E+V +L+ + LV AR
Sbjct: 411 FVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQE 470
Query: 474 IDSGPR 479
PR
Sbjct: 471 GHFLPR 476
Score = 35.9 bits (79), Expect = 0.45
Identities = 24/120 (20%), Positives = 56/120 (46%), Gaps = 1/120 (0%)
Query: 161 VIGDNPQKIPDHPIVCDSVSPTITITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKE 220
V+ D+ Q + D ++ + +T + V+++ LGI V +
Sbjct: 166 VVPDSTQNLEDREVLNGVQTELLTSPKTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLS 225
Query: 221 -ELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
+ G+F++ I + S +++ G N+ I++++ + L DK+ Q+ ++ R S ++L
Sbjct: 226 GRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLL 285
>AF428251-1|AAL30665.1| 1143|Homo sapiens partitioning-defective
3-like protein splice variant b protein.
Length = 1143
Score = 54.4 bits (125), Expect = 1e-06
Identities = 32/85 (37%), Positives = 49/85 (57%), Gaps = 7/85 (8%)
Query: 13 VELTNDGNGLGFNLVGGRST-----GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF +V S+ + +K +LP G A KD RLQSGD +L+V ++ G
Sbjct: 384 IDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTG 443
Query: 68 FTSEQVAAVLR--QAGPVVRLLVAR 90
T E++ A+LR + G L++AR
Sbjct: 444 RTQEELVAMLRSTKQGETASLVIAR 468
Score = 54.0 bits (124), Expect = 2e-06
Identities = 32/106 (30%), Positives = 57/106 (53%), Gaps = 3/106 (2%)
Query: 534 SRSLECVSGLAMWQSKEDI-VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAE 592
S SL + G ++ + I + L K +GLGF+++ + G + V ++++P G A
Sbjct: 364 SPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFV-KNILPKGAAI 422
Query: 593 KNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRG-TVKVGIAR 637
K+G + GDR++ VNG + T ++ V L+ +G T + IAR
Sbjct: 423 KDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIAR 468
Score = 50.0 bits (114), Expect = 3e-05
Identities = 30/87 (34%), Positives = 48/87 (55%), Gaps = 2/87 (2%)
Query: 197 IHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISL 256
I +DL K GLG TV IFVK+I+ +A + G+++ DRI+EV+G +
Sbjct: 382 IKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDV 441
Query: 257 ADKSNPQSVEILRNT--GISVHLVLER 281
++ + V +LR+T G + LV+ R
Sbjct: 442 TGRTQEELVAMLRSTKQGETASLVIAR 468
Score = 36.7 bits (81), Expect = 0.26
Identities = 22/66 (33%), Positives = 34/66 (51%), Gaps = 2/66 (3%)
Query: 416 YIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP--DRVRLVCARNS 473
+++++LP G G L +GD +LEVN + G T E+V +L+ + LV AR
Sbjct: 411 FVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQE 470
Query: 474 IDSGPR 479
PR
Sbjct: 471 GHFLPR 476
Score = 35.9 bits (79), Expect = 0.45
Identities = 15/35 (42%), Positives = 26/35 (74%)
Query: 237 EQSGKIKINDRIIEVDGISLADKSNPQSVEILRNT 271
E G++++ND++I V+G SL KSN +++E LR +
Sbjct: 477 ELDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRS 511
Score = 35.5 bits (78), Expect = 0.60
Identities = 24/120 (20%), Positives = 56/120 (46%), Gaps = 1/120 (0%)
Query: 161 VIGDNPQKIPDHPIVCDSVSPTITITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKE 220
V+ D+ Q + D ++ + +T + V+++ LGI V +
Sbjct: 166 VVPDSTQNLEDREVLNGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLS 225
Query: 221 -ELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
+ G+F++ I + S +++ G N+ I++++ + L DK+ Q+ ++ R S ++L
Sbjct: 226 GRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLL 285
>AC011750-1|AAY14757.1| 346|Homo sapiens unknown protein.
Length = 346
Score = 54.4 bits (125), Expect = 1e-06
Identities = 32/85 (37%), Positives = 49/85 (57%), Gaps = 7/85 (8%)
Query: 13 VELTNDGNGLGFNLVGGRST-----GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRG 67
++L GLGF +V S+ + +K +LP G A KD RLQSGD +L+V ++ G
Sbjct: 252 IDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTG 311
Query: 68 FTSEQVAAVLR--QAGPVVRLLVAR 90
T E++ A+LR + G L++AR
Sbjct: 312 RTQEELVAMLRSTKQGETASLVIAR 336
Score = 54.0 bits (124), Expect = 2e-06
Identities = 32/106 (30%), Positives = 57/106 (53%), Gaps = 3/106 (2%)
Query: 534 SRSLECVSGLAMWQSKEDI-VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAE 592
S SL + G ++ + I + L K +GLGF+++ + G + V ++++P G A
Sbjct: 232 SPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFV-KNILPKGAAI 290
Query: 593 KNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRG-TVKVGIAR 637
K+G + GDR++ VNG + T ++ V L+ +G T + IAR
Sbjct: 291 KDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIAR 336
Score = 50.0 bits (114), Expect = 3e-05
Identities = 30/87 (34%), Positives = 48/87 (55%), Gaps = 2/87 (2%)
Query: 197 IHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISL 256
I +DL K GLG TV IFVK+I+ +A + G+++ DRI+EV+G +
Sbjct: 250 IKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDV 309
Query: 257 ADKSNPQSVEILRNT--GISVHLVLER 281
++ + V +LR+T G + LV+ R
Sbjct: 310 TGRTQEELVAMLRSTKQGETASLVIAR 336
Score = 36.7 bits (81), Expect = 0.26
Identities = 22/66 (33%), Positives = 34/66 (51%), Gaps = 2/66 (3%)
Query: 416 YIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP--DRVRLVCARNS 473
+++++LP G G L +GD +LEVN + G T E+V +L+ + LV AR
Sbjct: 279 FVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQE 338
Query: 474 IDSGPR 479
PR
Sbjct: 339 GHFLPR 344
Score = 35.5 bits (78), Expect = 0.60
Identities = 24/120 (20%), Positives = 56/120 (46%), Gaps = 1/120 (0%)
Query: 161 VIGDNPQKIPDHPIVCDSVSPTITITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKE 220
V+ D+ Q + D ++ + +T + V+++ LGI V +
Sbjct: 34 VVPDSTQNLEDREVLNGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLS 93
Query: 221 -ELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVL 279
+ G+F++ I + S +++ G N+ I++++ + L DK+ Q+ ++ R S ++L
Sbjct: 94 GRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLL 153
>AC006043-1|AAD15413.2| 333|Homo sapiens unknown protein.
Length = 333
Score = 54.4 bits (125), Expect = 1e-06
Identities = 60/242 (24%), Positives = 99/242 (40%), Gaps = 28/242 (11%)
Query: 407 GGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP--DR 464
GG E ++SV+PDGP G + GD ++ +NE + G TH++VV + + +P
Sbjct: 93 GGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQSVPIGQS 152
Query: 465 VRLV-CARNSIDSGPRPVVNLASDREGFEAR--KIISGSLNNLTTLVKAQSDTSINTSST 521
V LV C + P N R ++ +N T ++ S TS +
Sbjct: 153 VNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETYLEYISRTSQSVPDI 212
Query: 522 ATLTNHSEQSKKSRSL-----------ECVSGLAMWQSKEDIVML--VKADQGLGFSILD 568
HS S + + VS + ++ +++ L VK QG GF+I D
Sbjct: 213 TDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQAELMTLTIVKGAQGFGFTIAD 272
Query: 569 YQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPR 628
P I+ PG + GD ++ +N ++QN + + V LK P
Sbjct: 273 --SPTGQRVKQILDIQGCPG--------LCEGDLIVEINQQNVQNLSHTEVVDILKDCPI 322
Query: 629 GT 630
G+
Sbjct: 323 GS 324
Score = 44.8 bits (101), Expect = 0.001
Identities = 29/98 (29%), Positives = 54/98 (55%), Gaps = 9/98 (9%)
Query: 555 LVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNA 614
L K++ G GF+I+ +P + + V+S++P G A ++G++ GD ++ +N V +
Sbjct: 80 LKKSNMGFGFTIIGGDEPDE----FLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGH 135
Query: 615 TLDQAVQALKGAPRG-TVKVGIAR--PLP--PQDSSKS 647
T V+ + P G +V + + R PLP P+D + S
Sbjct: 136 THADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANS 173
Score = 44.4 bits (100), Expect = 0.001
Identities = 65/279 (23%), Positives = 119/279 (42%), Gaps = 38/279 (13%)
Query: 15 LTNDGNGLGFNLVGGRSTG--VVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQ 72
L G GF ++GG + +K V+P G A +D ++++GD ++ + V + G T
Sbjct: 80 LKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHAD 139
Query: 73 VAAVLRQA--GPVVRLLVAR----PADPATALRAPQPGTALV--PTKILADPELLDRHLI 124
V + + G V L++ R P DP + P A++ P ++ + RH
Sbjct: 140 VVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVN----GRHNY 195
Query: 125 ETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQKIPDHPIVCDSVSPTIT 184
ET + SQ D I + + S+ + G P + D D+VS +
Sbjct: 196 ETYLEYISRTSQSVPD--ITDRPPHSLHSMPTDG-QLDGTYPPPVHD-----DNVSMASS 247
Query: 185 ITVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKI 244
EL + I+ K G G T+A + +G VK I++ + +
Sbjct: 248 GATQAELMTLTIV-----KGAQGFGFTIA------DSPTGQRVKQILD---IQGCPGLCE 293
Query: 245 NDRIIEVDGISLADKSNPQSVEILRN--TGISVHLVLER 281
D I+E++ ++ + S+ + V+IL++ G L++ R
Sbjct: 294 GDLIVEINQQNVQNLSHTEVVDILKDCPIGSETSLIIHR 332
>AB029018-1|BAA83047.1| 1098|Homo sapiens KIAA1095 protein protein.
Length = 1098
Score = 54.4 bits (125), Expect = 1e-06
Identities = 65/261 (24%), Positives = 117/261 (44%), Gaps = 47/261 (18%)
Query: 15 LTNDGNGLGFNLVGGR----------STGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
L D LGFN++GGR S G+ + ++ G A K+ LQ D +++V +
Sbjct: 284 LHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNGRD 343
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVPTKILADPELLDRHLI 124
L T +Q + A + + V R R P+ TK+ P + L+
Sbjct: 344 LSRATHDQAVEAFKTAKEPIVVQVLR--------RTPR-------TKMFTPPS--ESQLV 386
Query: 125 ETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQKIPD-HPIVCDSVSPTI 183
+TG + +I ++ T + + + V+ +P +P+ HP + P
Sbjct: 387 DTG-----------TQTDITFEHIMALTKMSSPSPPVL--DPYLLPEEHPSAHEYYDPND 433
Query: 184 ---TITVPVELPEIEIIHVDLNK--NVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQ 238
I ++ E+E+ VDL + + LG+TV Y + E+ GI++ I S A +
Sbjct: 434 YIGDIHQEMDREELELEEVDLYRMNSQDKLGLTVC-YRTDDEDDIGIYISEIDPNSIAAK 492
Query: 239 SGKIKINDRIIEVDGISLADK 259
G+I+ DRII+++GI + ++
Sbjct: 493 DGRIREGDRIIQINGIEVQNR 513
Score = 52.4 bits (120), Expect = 5e-06
Identities = 47/230 (20%), Positives = 91/230 (39%), Gaps = 15/230 (6%)
Query: 416 YIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLVCARNSID 475
++ ++ GP +G L D ++EVN L TH + V K + + + R +
Sbjct: 314 FVSKIVDSGPAAKEGGLQIHDRIIEVNGRDLSRATHDQAVEAFKTAKEPIVVQVLRRT-- 371
Query: 476 SGPRP-VVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTSSTATLTNHSEQSKKS 534
PR + S+ + + + ++ L K S + H +
Sbjct: 372 --PRTKMFTPPSESQLVDTGTQTDITFEHIMALTKMSSPSPPVLDPYLLPEEHPSAHEYY 429
Query: 535 RSLECVSGLAMWQSKEDIVM------LVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPG 588
+ + + +E++ + + + LG ++ D D G I + + P
Sbjct: 430 DPNDYIGDIHQEMDREELELEEVDLYRMNSQDKLGLTVCYRTDDEDDIG--IYISEIDPN 487
Query: 589 GVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIARP 638
+A K+G I GDR++ +NG+ +QN ++AV L + IARP
Sbjct: 488 SIAAKDGRIREGDRIIQINGIEVQNR--EEAVALLTSEENKNFSLLIARP 535
Score = 47.6 bits (108), Expect = 1e-04
Identities = 32/99 (32%), Positives = 51/99 (51%), Gaps = 6/99 (6%)
Query: 547 QSKEDIVMLVKADQG-LGFSILDYQDPVD----PNGTVIVVRSLVPGGVAEKNGEISPGD 601
+ + + +++ D G LGF+I+ + VD + I V +V G A K G + D
Sbjct: 275 EETKSLTLVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHD 334
Query: 602 RVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPLP 640
R++ VNG + AT DQAV+A K A + + V + R P
Sbjct: 335 RIIEVNGRDLSRATHDQAVEAFKTA-KEPIVVQVLRRTP 372
Score = 42.3 bits (95), Expect = 0.005
Identities = 19/46 (41%), Positives = 31/46 (67%)
Query: 224 GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILR 269
GIFV I++ A + G ++I+DRIIEV+G L+ ++ Q+VE +
Sbjct: 312 GIFVSKIVDSGPAAKEGGLQIHDRIIEVNGRDLSRATHDQAVEAFK 357
>AK131530-1|BAD18668.1| 1331|Homo sapiens protein ( Homo sapiens
cDNA FLJ16759 fis, clone BRACE3046450, highly similar
to Interleukin-16 precursor. ).
Length = 1331
Score = 54.0 bits (124), Expect = 2e-06
Identities = 58/254 (22%), Positives = 106/254 (41%), Gaps = 30/254 (11%)
Query: 393 EGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHS 452
+GLG S+ G D G Y++++ G G L GDE+LE+N + GLTH
Sbjct: 225 KGLGFSIVGGKDSIYGPI---GIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQ 281
Query: 453 EVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQS 512
+ + KQ + + R + + P +L+ + SL++ T + K S
Sbjct: 282 DALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPP---------LCRSLSSSTCITKDSS 332
Query: 513 DTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDP 572
++ + S T +K + ++ ++ + +A GLG + P
Sbjct: 333 SFALESPSAPIST-----AKPN-----------YRIMVEVSLQKEAGVGLGIGLCSV--P 374
Query: 573 VDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVK 632
+ I V +L PG VA +G + GD ++ ++ + TL++ L G V
Sbjct: 375 YFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVP 434
Query: 633 VGIARPLPPQDSSK 646
+ ++R PQ S +
Sbjct: 435 IIVSRHPDPQVSEQ 448
Score = 52.0 bits (119), Expect = 6e-06
Identities = 37/120 (30%), Positives = 59/120 (49%), Gaps = 5/120 (4%)
Query: 525 TNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPV-DPNGTVIVVR 583
T+ +S + L SG +IV++ +GLGFSI+ +D + P G I V+
Sbjct: 190 TSRPTRSLSTAQLVQPSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYGPIG--IYVK 247
Query: 584 SLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRG--TVKVGIARPLPP 641
++ GG A +G + GD ++ +NG S+ T A+Q K A +G T+ V PP
Sbjct: 248 TIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPP 307
Score = 52.0 bits (119), Expect = 6e-06
Identities = 26/84 (30%), Positives = 43/84 (51%), Gaps = 5/84 (5%)
Query: 12 VVELTNDGNGLGFNLVGGRST-----GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLR 66
+V + GLGF++VGG+ + G+ +K + GG A D RLQ GD +L++ ++
Sbjct: 217 IVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMA 276
Query: 67 GFTSEQVAAVLRQAGPVVRLLVAR 90
G T + +QA + L R
Sbjct: 277 GLTHQDALQKFKQAKKGLLTLTVR 300
Score = 51.6 bits (118), Expect = 9e-06
Identities = 28/81 (34%), Positives = 44/81 (54%), Gaps = 4/81 (4%)
Query: 18 DGNGLGFNLVGG---RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVA 74
+G GLGF+L GG + + + V P G+A ++ +Q G+ VL + +L+G T
Sbjct: 1120 EGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDAL 1179
Query: 75 AVLRQA-GPVVRLLVARPADP 94
A+LRQA P ++V R P
Sbjct: 1180 AILRQAREPRQAVIVTRKLTP 1200
Score = 49.2 bits (112), Expect = 5e-05
Identities = 45/165 (27%), Positives = 76/165 (46%), Gaps = 13/165 (7%)
Query: 325 TEIEPEPESNTTIDSSVLEVGD--LQEPTQEELDQRFDEILAVDKEDIVKKWKEEIGSDK 382
TE E + + D S L+ G + + EEL + +E+ +D+ + K+ G
Sbjct: 1058 TEGLTEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATL----KQLDGIHV 1113
Query: 383 EILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVN 442
IL E + GLG SL G D+E + + H V P+G +G + G+E+L +N
Sbjct: 1114 TILHKE--EGAGLGFSLAGGADLEN-KVITVHR----VFPNGLASQEGTIQKGNEVLSIN 1166
Query: 443 EYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASD 487
L G TH + + IL+Q + + V + P +N ++D
Sbjct: 1167 GKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTD 1211
Score = 48.0 bits (109), Expect = 1e-04
Identities = 28/82 (34%), Positives = 41/82 (50%), Gaps = 3/82 (3%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLGFS+ D VI V + P G+A + G I G+ V+S+NG S++ T A+
Sbjct: 1123 GLGFSLAG---GADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDAL 1179
Query: 621 QALKGAPRGTVKVGIARPLPPQ 642
L+ A V + R L P+
Sbjct: 1180 AILRQAREPRQAVIVTRKLTPE 1201
Score = 44.4 bits (100), Expect = 0.001
Identities = 29/112 (25%), Positives = 51/112 (45%), Gaps = 1/112 (0%)
Query: 526 NHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSL 585
N S S S S + ++ V L K GLGFS+ + + + + + R +
Sbjct: 1207 NSSTDSAASASAASDVSVESTEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINR-I 1265
Query: 586 VPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIAR 637
G +E++ + PGD ++ + G ++Q T +A +K P G V + I R
Sbjct: 1266 FKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRR 1317
Score = 40.7 bits (91), Expect = 0.016
Identities = 28/89 (31%), Positives = 45/89 (50%), Gaps = 8/89 (8%)
Query: 2 VLSTEWAQVEVVELTNDGNGLGFNLVGGRST-----GVVIKYVLPGGVADKDRRLQSGDH 56
V STE A V V L GLGF+L GG+ + + I + G +++ +Q GD
Sbjct: 1224 VESTE-ATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDE 1282
Query: 57 VLQVGSVNLRGFTSEQVAAVLRQA--GPV 83
+LQ+G ++G T + +++ GPV
Sbjct: 1283 ILQLGGTAMQGLTRFEAWNIIKALPDGPV 1311
Score = 40.3 bits (90), Expect = 0.021
Identities = 30/89 (33%), Positives = 43/89 (48%), Gaps = 6/89 (6%)
Query: 390 KKLEGLGISLEGTV-DVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHG 448
K GLG SLEG + G + L + + + +Q GDE+L++ + G
Sbjct: 1238 KMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQ----PGDEILQLGGTAMQG 1293
Query: 449 LTHSEVVNILKQLPD-RVRLVCARNSIDS 476
LT E NI+K LPD V +V R S+ S
Sbjct: 1294 LTRFEAWNIIKALPDGPVTIVIRRKSLQS 1322
Score = 39.1 bits (87), Expect = 0.049
Identities = 27/90 (30%), Positives = 42/90 (46%), Gaps = 5/90 (5%)
Query: 10 VEVVELTNDGNGLGFNLVGGRS----TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
VEV G GLG L +G+ + + PG VA D RL+ GD ++++ +
Sbjct: 354 VEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPV 413
Query: 66 RGFTSEQVAAVLRQAGP-VVRLLVARPADP 94
T +V +L P V ++V+R DP
Sbjct: 414 HCLTLNEVYTILSHCDPGPVPIIVSRHPDP 443
Score = 37.5 bits (83), Expect = 0.15
Identities = 18/60 (30%), Positives = 35/60 (58%)
Query: 207 GLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVE 266
GLG ++ G GI+VK+I G +A G+++ D I+E++G S+A ++ +++
Sbjct: 226 GLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQ 285
Score = 33.9 bits (74), Expect = 1.8
Identities = 20/57 (35%), Positives = 32/57 (56%), Gaps = 2/57 (3%)
Query: 196 IIHVDLNKNV-YGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEV 251
++ V L K GLGI + V + +SGIFV ++ GS A G+++ D I+E+
Sbjct: 353 MVEVSLQKEAGVGLGIGLCS-VPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEI 408
>AK124565-1|BAC85888.1| 1163|Homo sapiens protein ( Homo sapiens
cDNA FLJ42574 fis, clone BRACE3008137, highly similar
to Interleukin-16 precursor. ).
Length = 1163
Score = 54.0 bits (124), Expect = 2e-06
Identities = 58/254 (22%), Positives = 106/254 (41%), Gaps = 30/254 (11%)
Query: 393 EGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHS 452
+GLG S+ G D G Y++++ G G L GDE+LE+N + GLTH
Sbjct: 57 KGLGFSIVGGKDSIYGPI---GIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQ 113
Query: 453 EVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQS 512
+ + KQ + + R + + P +L+ + SL++ T + K S
Sbjct: 114 DALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPP---------LCRSLSSSTCITKDSS 164
Query: 513 DTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDP 572
++ + S T +K + ++ ++ + +A GLG + P
Sbjct: 165 SFALESPSAPIST-----AKPN-----------YRIMVEVSLQKEAGVGLGIGLCSV--P 206
Query: 573 VDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVK 632
+ I V +L PG VA +G + GD ++ ++ + TL++ L G V
Sbjct: 207 YFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVP 266
Query: 633 VGIARPLPPQDSSK 646
+ ++R PQ S +
Sbjct: 267 IIVSRHPDPQVSEQ 280
Score = 52.0 bits (119), Expect = 6e-06
Identities = 37/120 (30%), Positives = 59/120 (49%), Gaps = 5/120 (4%)
Query: 525 TNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPV-DPNGTVIVVR 583
T+ +S + L SG +IV++ +GLGFSI+ +D + P G I V+
Sbjct: 22 TSRPTRSLSTAQLVQPSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYGPIG--IYVK 79
Query: 584 SLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRG--TVKVGIARPLPP 641
++ GG A +G + GD ++ +NG S+ T A+Q K A +G T+ V PP
Sbjct: 80 TIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPP 139
Score = 52.0 bits (119), Expect = 6e-06
Identities = 26/84 (30%), Positives = 43/84 (51%), Gaps = 5/84 (5%)
Query: 12 VVELTNDGNGLGFNLVGGRST-----GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLR 66
+V + GLGF++VGG+ + G+ +K + GG A D RLQ GD +L++ ++
Sbjct: 49 IVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMA 108
Query: 67 GFTSEQVAAVLRQAGPVVRLLVAR 90
G T + +QA + L R
Sbjct: 109 GLTHQDALQKFKQAKKGLLTLTVR 132
Score = 51.6 bits (118), Expect = 9e-06
Identities = 28/81 (34%), Positives = 44/81 (54%), Gaps = 4/81 (4%)
Query: 18 DGNGLGFNLVGG---RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVA 74
+G GLGF+L GG + + + V P G+A ++ +Q G+ VL + +L+G T
Sbjct: 952 EGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDAL 1011
Query: 75 AVLRQA-GPVVRLLVARPADP 94
A+LRQA P ++V R P
Sbjct: 1012 AILRQAREPRQAVIVTRKLTP 1032
Score = 49.2 bits (112), Expect = 5e-05
Identities = 45/165 (27%), Positives = 76/165 (46%), Gaps = 13/165 (7%)
Query: 325 TEIEPEPESNTTIDSSVLEVGD--LQEPTQEELDQRFDEILAVDKEDIVKKWKEEIGSDK 382
TE E + + D S L+ G + + EEL + +E+ +D+ + K+ G
Sbjct: 890 TEGLTEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATL----KQLDGIHV 945
Query: 383 EILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVN 442
IL E + GLG SL G D+E + + H V P+G +G + G+E+L +N
Sbjct: 946 TILHKE--EGAGLGFSLAGGADLEN-KVITVHR----VFPNGLASQEGTIQKGNEVLSIN 998
Query: 443 EYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASD 487
L G TH + + IL+Q + + V + P +N ++D
Sbjct: 999 GKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTD 1043
Score = 48.0 bits (109), Expect = 1e-04
Identities = 28/82 (34%), Positives = 41/82 (50%), Gaps = 3/82 (3%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLGFS+ D VI V + P G+A + G I G+ V+S+NG S++ T A+
Sbjct: 955 GLGFSLAG---GADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDAL 1011
Query: 621 QALKGAPRGTVKVGIARPLPPQ 642
L+ A V + R L P+
Sbjct: 1012 AILRQAREPRQAVIVTRKLTPE 1033
Score = 44.4 bits (100), Expect = 0.001
Identities = 29/112 (25%), Positives = 51/112 (45%), Gaps = 1/112 (0%)
Query: 526 NHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSL 585
N S S S S + ++ V L K GLGFS+ + + + + + R +
Sbjct: 1039 NSSTDSAASASAASDVSVESTEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINR-I 1097
Query: 586 VPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIAR 637
G +E++ + PGD ++ + G ++Q T +A +K P G V + I R
Sbjct: 1098 FKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRR 1149
Score = 40.7 bits (91), Expect = 0.016
Identities = 28/89 (31%), Positives = 45/89 (50%), Gaps = 8/89 (8%)
Query: 2 VLSTEWAQVEVVELTNDGNGLGFNLVGGRST-----GVVIKYVLPGGVADKDRRLQSGDH 56
V STE A V V L GLGF+L GG+ + + I + G +++ +Q GD
Sbjct: 1056 VESTE-ATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDE 1114
Query: 57 VLQVGSVNLRGFTSEQVAAVLRQA--GPV 83
+LQ+G ++G T + +++ GPV
Sbjct: 1115 ILQLGGTAMQGLTRFEAWNIIKALPDGPV 1143
Score = 40.3 bits (90), Expect = 0.021
Identities = 30/89 (33%), Positives = 43/89 (48%), Gaps = 6/89 (6%)
Query: 390 KKLEGLGISLEGTV-DVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHG 448
K GLG SLEG + G + L + + + +Q GDE+L++ + G
Sbjct: 1070 KMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQ----PGDEILQLGGTAMQG 1125
Query: 449 LTHSEVVNILKQLPD-RVRLVCARNSIDS 476
LT E NI+K LPD V +V R S+ S
Sbjct: 1126 LTRFEAWNIIKALPDGPVTIVIRRKSLQS 1154
Score = 39.1 bits (87), Expect = 0.049
Identities = 27/90 (30%), Positives = 42/90 (46%), Gaps = 5/90 (5%)
Query: 10 VEVVELTNDGNGLGFNLVGGRS----TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
VEV G GLG L +G+ + + PG VA D RL+ GD ++++ +
Sbjct: 186 VEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPV 245
Query: 66 RGFTSEQVAAVLRQAGP-VVRLLVARPADP 94
T +V +L P V ++V+R DP
Sbjct: 246 HCLTLNEVYTILSHCDPGPVPIIVSRHPDP 275
Score = 37.5 bits (83), Expect = 0.15
Identities = 18/60 (30%), Positives = 35/60 (58%)
Query: 207 GLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVE 266
GLG ++ G GI+VK+I G +A G+++ D I+E++G S+A ++ +++
Sbjct: 58 GLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQ 117
Score = 33.9 bits (74), Expect = 1.8
Identities = 20/57 (35%), Positives = 32/57 (56%), Gaps = 2/57 (3%)
Query: 196 IIHVDLNKNV-YGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEV 251
++ V L K GLGI + V + +SGIFV ++ GS A G+++ D I+E+
Sbjct: 185 MVEVSLQKEAGVGLGIGLCS-VPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEI 240
>AB051506-1|BAB21810.2| 1050|Homo sapiens KIAA1719 protein protein.
Length = 1050
Score = 54.0 bits (124), Expect = 2e-06
Identities = 66/303 (21%), Positives = 125/303 (41%), Gaps = 43/303 (14%)
Query: 10 VEVVELTNDGNGLGFNLVGGRSTGVV-IKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGF 68
VE+V+ G+ R+ V+ I + P V D+ L GDH+L + ++
Sbjct: 256 VEIVKTPGSALGISLTTTSLRNKSVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHC 315
Query: 69 TSEQVAAVLRQAGPVVRLLV------ARPADPATALR------------------APQPG 104
+ + +L VRL + RP P+ A++ +P+PG
Sbjct: 316 SLLEATKLLASISEKVRLEILPVPQSQRPLRPSEAVKVQRSEQLHRWDPCVPSCHSPRPG 375
Query: 105 TALVPTKILADPELLDRHLIETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGD 164
+PT + R L T + + L+ +S N + S + + +G
Sbjct: 376 HCRMPTWATPAGQDQSRSLSSTPFSSP-TLNHAFS---CNNPSTLPRGSQPMSPRTTMGR 431
Query: 165 NPQKIPDHPIVCDSVSPTITITVPVELPEIEIIHVDLNKNVY------GLGITVAGYVCE 218
Q+ +H S T+ P +I+H + + V G G+ + G +
Sbjct: 432 RRQRRREHKSSLSLASSTVG-------PGGQIVHTETTEVVLCGDPLSGFGLQLQGGIFA 484
Query: 219 KEELSGIFVKSIIE-GSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHL 277
E LS + IE S AE+ G +++ DR++ ++GI+ D + ++ ++LR+ ++ +
Sbjct: 485 TETLSSPPLVCFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEEANQLLRDAALAHKV 544
Query: 278 VLE 280
VLE
Sbjct: 545 VLE 547
Score = 52.8 bits (121), Expect = 4e-06
Identities = 31/97 (31%), Positives = 52/97 (53%), Gaps = 7/97 (7%)
Query: 562 LGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQ 621
LG +I ++P DP IV+ L G+AE+ G I GDR++++N VS++ L +A+
Sbjct: 673 LGITISGTEEPFDP----IVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSEAIH 728
Query: 622 ALKGAPRGT---VKVGIARPLPPQDSSKSKGTINVNK 655
L+ A +K + RPL P+ S T + ++
Sbjct: 729 LLQVAGETVTLKIKKQLDRPLLPRKSGSLSETSDADE 765
Score = 50.4 bits (115), Expect = 2e-05
Identities = 35/98 (35%), Positives = 45/98 (45%), Gaps = 7/98 (7%)
Query: 13 VELTNDGNGLGFNLVGG------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLR 66
V L +GN GF L GG +S +V+ YV PGG AD++ L+ GD +L V + L
Sbjct: 156 VSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLH 215
Query: 67 GFTSEQVAAVLRQAGPVVRLLVARP-ADPATALRAPQP 103
G + A LRQ V A P T A P
Sbjct: 216 GASHATALATLRQCSHEALFQVEYDVATPDTVANASGP 253
Score = 47.6 bits (108), Expect = 1e-04
Identities = 63/291 (21%), Positives = 119/291 (40%), Gaps = 20/291 (6%)
Query: 11 EVVELTNDGNGLGFNLVGG------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
EVV + +G G L GG S+ ++ ++ P A++ LQ GD VL + +
Sbjct: 463 EVVLCGDPLSGFGLQLQGGIFATETLSSPPLVCFIEPDSPAERCGLLQVGDRVLSINGIA 522
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQPGTALVPTKILADPEL-LDRHL 123
T E+ +LR A ++++ D A ++ P GT V EL +
Sbjct: 523 TEDGTMEEANQLLRDAALAHKVVLEVEFDVAESV-IPSSGTFHVKLPKKRSVELGITISS 581
Query: 124 IETGYGAVYDLSQCYSDYNINGQNGETETSIVAAAVSVIGDNPQKIPDHPIVCDSVSPTI 183
G +S ++ + G E A+ I + + D + +
Sbjct: 582 ASRKRGEPLIISDIKKG-SVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCEDLV 640
Query: 184 TITVPV------ELPEIEIIHVDLNKNVYG--LGITVAGYVCEKEELSGIFVKSIIEGSS 235
+ + EL + + YG LGIT++G +E I + + +
Sbjct: 641 KLKIRKDEDNSDELETTGAVSYTVELKRYGGPLGITISG---TEEPFDPIVISGLTKRGL 697
Query: 236 AEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLERYLRGP 286
AE++G I + DRI+ ++ +SL + +++ +L+ G +V L +++ L P
Sbjct: 698 AERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQVAGETVTLKIKKQLDRP 748
Score = 44.8 bits (101), Expect = 0.001
Identities = 29/86 (33%), Positives = 45/86 (52%), Gaps = 8/86 (9%)
Query: 384 ILVAEIKKLEG--LGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEV 441
I V E+ K EG LG+++ G D +G +P + ++ P G +LN GD + V
Sbjct: 53 ITVVELIKKEGSTLGLTISGGTDKDG----KPR--VSNLRPGGLAARSDLLNIGDYIRSV 106
Query: 442 NEYRLHGLTHSEVVNILKQLPDRVRL 467
N L L H E++ +LK + +RV L
Sbjct: 107 NGIHLTRLRHDEIITLLKNVGERVVL 132
Score = 43.6 bits (98), Expect = 0.002
Identities = 18/76 (23%), Positives = 41/76 (53%), Gaps = 1/76 (1%)
Query: 577 GTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIA 636
G +++ + G VA + G + PGD++++++ + + N ++ AVQ L+ VK+ I
Sbjct: 587 GEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQC-EDLVKLKIR 645
Query: 637 RPLPPQDSSKSKGTIN 652
+ D ++ G ++
Sbjct: 646 KDEDNSDELETTGAVS 661
Score = 43.2 bits (97), Expect = 0.003
Identities = 31/84 (36%), Positives = 43/84 (51%), Gaps = 3/84 (3%)
Query: 23 GFNLVGGR-STGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAVLRQAG 81
GF++ G GV + V P G A + LQ D VLQV V R F +L +AG
Sbjct: 961 GFSVSDGLLEKGVYVHTVRPDGPAHRGG-LQPFDRVLQVNHVRTRDFDCCLAVPLLAEAG 1019
Query: 82 PVVRLLVARPADPATALRAPQ-PG 104
V+ L+++R A + RAP+ PG
Sbjct: 1020 DVLELIISRKPHTAHSSRAPRSPG 1043
Score = 41.9 bits (94), Expect = 0.007
Identities = 27/79 (34%), Positives = 38/79 (48%), Gaps = 2/79 (2%)
Query: 382 KEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEV 441
K + V+ K+ G L G E G + RP + V P GP +G L GD LL V
Sbjct: 152 KTVDVSLYKEGNSFGFVLRGGAH-EDGHKSRPL-VLTYVRPGGPADREGSLKVGDRLLSV 209
Query: 442 NEYRLHGLTHSEVVNILKQ 460
+ LHG +H+ + L+Q
Sbjct: 210 DGIPLHGASHATALATLRQ 228
Score = 40.3 bits (90), Expect = 0.021
Identities = 33/131 (25%), Positives = 58/131 (44%), Gaps = 5/131 (3%)
Query: 500 SLNNLTTLVKAQSDTSINTSSTATLTNHSEQSKKSRSLECVS----GLAMWQSKEDIVML 555
S NN +TL + S T+ E K S SL + G + ++V+
Sbjct: 409 SCNNPSTLPRGSQPMSPRTTMGRRRQRRREH-KSSLSLASSTVGPGGQIVHTETTEVVLC 467
Query: 556 VKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNAT 615
G G + + + +V + P AE+ G + GDRV+S+NG++ ++ T
Sbjct: 468 GDPLSGFGLQLQGGIFATETLSSPPLVCFIEPDSPAERCGLLQVGDRVLSINGIATEDGT 527
Query: 616 LDQAVQALKGA 626
+++A Q L+ A
Sbjct: 528 MEEANQLLRDA 538
Score = 39.9 bits (89), Expect = 0.028
Identities = 26/93 (27%), Positives = 43/93 (46%), Gaps = 2/93 (2%)
Query: 3 LSTEWAQVEVVELTNDGNGLGFNLVGGRST--GVVIKYVLPGGVADKDRRLQSGDHVLQV 60
L T A VEL G LG + G +VI + G+A++ + GD +L +
Sbjct: 654 LETTGAVSYTVELKRYGGPLGITISGTEEPFDPIVISGLTKRGLAERTGAIHVGDRILAI 713
Query: 61 GSVNLRGFTSEQVAAVLRQAGPVVRLLVARPAD 93
+V+L+G + +L+ AG V L + + D
Sbjct: 714 NNVSLKGRPLSEAIHLLQVAGETVTLKIKKQLD 746
Score = 38.7 bits (86), Expect = 0.064
Identities = 26/100 (26%), Positives = 46/100 (46%), Gaps = 3/100 (3%)
Query: 6 EWAQVEVVELTN-DGNGLGFNLVGG--RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGS 62
E+ + VVEL +G+ LG + GG + + + PGG+A + L GD++ V
Sbjct: 49 EFRGITVVELIKKEGSTLGLTISGGTDKDGKPRVSNLRPGGLAARSDLLNIGDYIRSVNG 108
Query: 63 VNLRGFTSEQVAAVLRQAGPVVRLLVARPADPATALRAPQ 102
++L +++ +L+ G V L V P P+
Sbjct: 109 IHLTRLRHDEIITLLKNVGERVVLEVEYELPPPAPENNPR 148
Score = 38.7 bits (86), Expect = 0.064
Identities = 22/77 (28%), Positives = 37/77 (48%)
Query: 548 SKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVN 607
SK V L K GF + +V+ + PGG A++ G + GDR++SV+
Sbjct: 151 SKTVDVSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVD 210
Query: 608 GVSIQNATLDQAVQALK 624
G+ + A+ A+ L+
Sbjct: 211 GIPLHGASHATALATLR 227
Score = 36.7 bits (81), Expect = 0.26
Identities = 22/74 (29%), Positives = 35/74 (47%), Gaps = 1/74 (1%)
Query: 197 IHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIE-GSSAEQSGKIKINDRIIEVDGIS 255
+ V L K G + G E S V + + G A++ G +K+ DR++ VDGI
Sbjct: 154 VDVSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIP 213
Query: 256 LADKSNPQSVEILR 269
L S+ ++ LR
Sbjct: 214 LHGASHATALATLR 227
Score = 35.9 bits (79), Expect = 0.45
Identities = 19/60 (31%), Positives = 32/60 (53%), Gaps = 1/60 (1%)
Query: 582 VRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPLPP 641
V +L PGG+A ++ ++ GD + SVNG+ + D+ + LK V + + LPP
Sbjct: 82 VSNLRPGGLAARSDLLNIGDYIRSVNGIHLTRLRHDEIITLLKNVGERVV-LEVEYELPP 140
Score = 35.5 bits (78), Expect = 0.60
Identities = 29/105 (27%), Positives = 52/105 (49%), Gaps = 4/105 (3%)
Query: 186 TVPVELPEIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKIN 245
++P E I ++ + + K LG+T++G +K+ V ++ G A +S + I
Sbjct: 45 SIPEEFRGITVVEL-IKKEGSTLGLTISGGT-DKDGKPR--VSNLRPGGLAARSDLLNIG 100
Query: 246 DRIIEVDGISLADKSNPQSVEILRNTGISVHLVLERYLRGPKFEH 290
D I V+GI L + + + +L+N G V L +E L P E+
Sbjct: 101 DYIRSVNGIHLTRLRHDEIITLLKNVGERVVLEVEYELPPPAPEN 145
Score = 34.3 bits (75), Expect = 1.4
Identities = 23/80 (28%), Positives = 37/80 (46%), Gaps = 1/80 (1%)
Query: 398 SLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQ-GVLNAGDELLEVNEYRLHGLTHSEVVN 456
S+E + + R I S + G V + G L GD+LL ++ RL + V
Sbjct: 572 SVELGITISSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQ 631
Query: 457 ILKQLPDRVRLVCARNSIDS 476
IL+Q D V+L ++ +S
Sbjct: 632 ILRQCEDLVKLKIRKDEDNS 651
>U02478-1|AAC50059.1| 1612|Homo sapiens AF-6 protein.
Length = 1612
Score = 53.6 bits (123), Expect = 2e-06
Identities = 28/85 (32%), Positives = 49/85 (57%), Gaps = 1/85 (1%)
Query: 193 EIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVD 252
E EII V L K G+G+++ ++ GI+VKS+++G +A+ G++ D+++ VD
Sbjct: 988 EPEIITVTLKKQ-NGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVD 1046
Query: 253 GISLADKSNPQSVEILRNTGISVHL 277
G SL S ++ E++ T V L
Sbjct: 1047 GRSLVGLSQERAAELMTRTSSVVTL 1071
Score = 52.8 bits (121), Expect = 4e-06
Identities = 34/103 (33%), Positives = 53/103 (51%), Gaps = 10/103 (9%)
Query: 11 EVVELT-NDGNGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
E++ +T NG+G ++V + G + +K V+ GG AD D RL +GD +L V +
Sbjct: 990 EIITVTLKKQNGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGRS 1049
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARPA----DPATALRAPQP 103
L G + E+ A ++ + VV L VA+ AT L P P
Sbjct: 1050 LVGLSQERAAELMTRTSSVVTLEVAKQGAIYHGLATLLNQPSP 1092
Score = 48.8 bits (111), Expect = 6e-05
Identities = 35/123 (28%), Positives = 60/123 (48%), Gaps = 11/123 (8%)
Query: 376 EEIGSDKEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAG 435
+ + + EI+ +KK G+G+S+ V +G + + Y++SV+ G + G L AG
Sbjct: 983 QPLRKEPEIITVTLKKQNGMGLSI---VAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAG 1039
Query: 436 DELLEVNEYRLHGLTHSEVVNILKQLPDRVRL-VCARNSIDSG-------PRPVVNLASD 487
D+LL V+ L GL+ ++ + V L V + +I G P P++ SD
Sbjct: 1040 DQLLSVDGRSLVGLSQERAAELMTRTSSVVTLEVAKQGAIYHGLATLLNQPSPMMQRISD 1099
Query: 488 REG 490
R G
Sbjct: 1100 RRG 1102
Score = 41.9 bits (94), Expect = 0.007
Identities = 22/74 (29%), Positives = 44/74 (59%), Gaps = 1/74 (1%)
Query: 550 EDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGV 609
E I + +K G+G SI+ + + I V+S+V GG A+ +G ++ GD+++SV+G
Sbjct: 990 EIITVTLKKQNGMGLSIVAAKG-AGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGR 1048
Query: 610 SIQNATLDQAVQAL 623
S+ + ++A + +
Sbjct: 1049 SLVGLSQERAAELM 1062
>BC040272-1|AAH40272.1| 454|Homo sapiens IL16 protein protein.
Length = 454
Score = 53.6 bits (123), Expect = 2e-06
Identities = 57/250 (22%), Positives = 104/250 (41%), Gaps = 30/250 (12%)
Query: 393 EGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHS 452
+GLG S+ G D G Y++++ G G L GDE+LE+N + GLTH
Sbjct: 225 KGLGFSIVGGKDSIYGPI---GIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQ 281
Query: 453 EVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQS 512
+ + KQ + + R + + P +L+ + SL++ T + K S
Sbjct: 282 DALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPP---------LCRSLSSSTCITKDSS 332
Query: 513 DTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDP 572
++ + S T +K + ++ ++ + +A GLG + P
Sbjct: 333 SFALESPSAPIST-----AKPN-----------YRIMVEVSLQKEAGVGLGIGLCSV--P 374
Query: 573 VDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVK 632
+ I V +L PG VA +G + GD ++ ++ + TL++ L G V
Sbjct: 375 YFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVS 434
Query: 633 VGIARPLPPQ 642
+ ++R PQ
Sbjct: 435 IIVSRHPDPQ 444
Score = 52.0 bits (119), Expect = 6e-06
Identities = 37/120 (30%), Positives = 59/120 (49%), Gaps = 5/120 (4%)
Query: 525 TNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPV-DPNGTVIVVR 583
T+ +S + L SG +IV++ +GLGFSI+ +D + P G I V+
Sbjct: 190 TSRPTRSLSTAQLVQPSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYGPIG--IYVK 247
Query: 584 SLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRG--TVKVGIARPLPP 641
++ GG A +G + GD ++ +NG S+ T A+Q K A +G T+ V PP
Sbjct: 248 TIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPP 307
Score = 52.0 bits (119), Expect = 6e-06
Identities = 26/84 (30%), Positives = 43/84 (51%), Gaps = 5/84 (5%)
Query: 12 VVELTNDGNGLGFNLVGGRST-----GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLR 66
+V + GLGF++VGG+ + G+ +K + GG A D RLQ GD +L++ ++
Sbjct: 217 IVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMA 276
Query: 67 GFTSEQVAAVLRQAGPVVRLLVAR 90
G T + +QA + L R
Sbjct: 277 GLTHQDALQKFKQAKKGLLTLTVR 300
Score = 39.5 bits (88), Expect = 0.037
Identities = 27/90 (30%), Positives = 42/90 (46%), Gaps = 5/90 (5%)
Query: 10 VEVVELTNDGNGLGFNLVGGRS----TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
VEV G GLG L +G+ + + PG VA D RL+ GD ++++ +
Sbjct: 354 VEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPV 413
Query: 66 RGFTSEQVAAVLRQAGP-VVRLLVARPADP 94
T +V +L P V ++V+R DP
Sbjct: 414 HCLTLNEVYTILSHCDPGPVSIIVSRHPDP 443
Score = 37.5 bits (83), Expect = 0.15
Identities = 18/60 (30%), Positives = 35/60 (58%)
Query: 207 GLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVE 266
GLG ++ G GI+VK+I G +A G+++ D I+E++G S+A ++ +++
Sbjct: 226 GLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQ 285
Score = 33.9 bits (74), Expect = 1.8
Identities = 20/57 (35%), Positives = 32/57 (56%), Gaps = 2/57 (3%)
Query: 196 IIHVDLNKNV-YGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEV 251
++ V L K GLGI + V + +SGIFV ++ GS A G+++ D I+E+
Sbjct: 353 MVEVSLQKEAGVGLGIGLCS-VPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEI 408
>AY324389-1|AAQ86961.1| 1332|Homo sapiens neural interleukin 16
precursor protein protein.
Length = 1332
Score = 53.6 bits (123), Expect = 2e-06
Identities = 58/254 (22%), Positives = 106/254 (41%), Gaps = 30/254 (11%)
Query: 393 EGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHS 452
+GLG S+ G D G Y++++ G G L GDE+LE+N + GLTH
Sbjct: 225 KGLGFSIVGGKDSIYGPI---GIYVKTIFAGGAAAADGRLQEGDEILELNGGSMAGLTHQ 281
Query: 453 EVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQS 512
+ + KQ + + R + + P +L+ + SL++ T + K S
Sbjct: 282 DALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPP---------LCRSLSSSTCITKDSS 332
Query: 513 DTSINTSSTATLTNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDP 572
++ + S T +K + ++ ++ + +A GLG + P
Sbjct: 333 SFALESPSAPIST-----AKPN-----------YRIMVEVSLQKEAGVGLGIGLCSV--P 374
Query: 573 VDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVK 632
+ I V +L PG VA +G + GD ++ ++ + TL++ L G V
Sbjct: 375 YFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVP 434
Query: 633 VGIARPLPPQDSSK 646
+ ++R PQ S +
Sbjct: 435 IIVSRHPDPQVSEQ 448
Score = 51.6 bits (118), Expect = 9e-06
Identities = 37/120 (30%), Positives = 59/120 (49%), Gaps = 5/120 (4%)
Query: 525 TNHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPV-DPNGTVIVVR 583
T+ +S + L SG +IV++ +GLGFSI+ +D + P G I V+
Sbjct: 190 TSRPTRSLSTAQLVQPSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYGPIG--IYVK 247
Query: 584 SLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRG--TVKVGIARPLPP 641
++ GG A +G + GD ++ +NG S+ T A+Q K A +G T+ V PP
Sbjct: 248 TIFAGGAAAADGRLQEGDEILELNGGSMAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPP 307
Score = 51.6 bits (118), Expect = 9e-06
Identities = 26/84 (30%), Positives = 43/84 (51%), Gaps = 5/84 (5%)
Query: 12 VVELTNDGNGLGFNLVGGRST-----GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLR 66
+V + GLGF++VGG+ + G+ +K + GG A D RLQ GD +L++ ++
Sbjct: 217 IVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGGSMA 276
Query: 67 GFTSEQVAAVLRQAGPVVRLLVAR 90
G T + +QA + L R
Sbjct: 277 GLTHQDALQKFKQAKKGLLTLTVR 300
Score = 51.6 bits (118), Expect = 9e-06
Identities = 28/81 (34%), Positives = 44/81 (54%), Gaps = 4/81 (4%)
Query: 18 DGNGLGFNLVGG---RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVA 74
+G GLGF+L GG + + + V P G+A ++ +Q G+ VL + +L+G T
Sbjct: 1120 EGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDAL 1179
Query: 75 AVLRQA-GPVVRLLVARPADP 94
A+LRQA P ++V R P
Sbjct: 1180 AILRQAREPRQAVIVTRKLTP 1200
Score = 49.2 bits (112), Expect = 5e-05
Identities = 45/165 (27%), Positives = 76/165 (46%), Gaps = 13/165 (7%)
Query: 325 TEIEPEPESNTTIDSSVLEVGD--LQEPTQEELDQRFDEILAVDKEDIVKKWKEEIGSDK 382
TE E + + D S L+ G + + EEL + +E+ +D+ + K+ G
Sbjct: 1058 TEGLTEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATL----KQLDGIHV 1113
Query: 383 EILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVN 442
IL E + GLG SL G D+E + + H V P+G +G + G+E+L +N
Sbjct: 1114 TILHKE--EGAGLGFSLAGGADLEN-KVITVHR----VFPNGLASQEGTIQKGNEVLSIN 1166
Query: 443 EYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASD 487
L G TH + + IL+Q + + V + P +N ++D
Sbjct: 1167 GKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTD 1211
Score = 48.0 bits (109), Expect = 1e-04
Identities = 28/82 (34%), Positives = 41/82 (50%), Gaps = 3/82 (3%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLGFS+ D VI V + P G+A + G I G+ V+S+NG S++ T A+
Sbjct: 1123 GLGFSLAG---GADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDAL 1179
Query: 621 QALKGAPRGTVKVGIARPLPPQ 642
L+ A V + R L P+
Sbjct: 1180 AILRQAREPRQAVIVTRKLTPE 1201
Score = 43.6 bits (98), Expect = 0.002
Identities = 24/85 (28%), Positives = 43/85 (50%), Gaps = 1/85 (1%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
V L K GLGFS+ + + + + + R + G +E++ + PGD ++ + G ++Q
Sbjct: 1235 VTLEKMSAGLGFSLEGGKGSLHGDKPLTINR-IFKGAASEQSETVQPGDEILQLGGTAMQ 1293
Query: 613 NATLDQAVQALKGAPRGTVKVGIAR 637
T +A +K P G V + I R
Sbjct: 1294 GLTRFEAWNIIKALPDGPVTIVIRR 1318
Score = 41.5 bits (93), Expect = 0.009
Identities = 27/89 (30%), Positives = 44/89 (49%), Gaps = 7/89 (7%)
Query: 2 VLSTEWAQVEVVELTNDGNGLGFNLVGGRST-----GVVIKYVLPGGVADKDRRLQSGDH 56
V ST A V V L GLGF+L GG+ + + I + G +++ +Q GD
Sbjct: 1224 VESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDE 1283
Query: 57 VLQVGSVNLRGFTSEQVAAVLRQA--GPV 83
+LQ+G ++G T + +++ GPV
Sbjct: 1284 ILQLGGTAMQGLTRFEAWNIIKALPDGPV 1312
Score = 40.7 bits (91), Expect = 0.016
Identities = 31/103 (30%), Positives = 50/103 (48%), Gaps = 7/103 (6%)
Query: 377 EIGSDKEILVAEIKKLE-GLGISLEGTV-DVEGGQELRPHHYIRSVLPDGPVGLQGVLNA 434
E ++ + ++K+ GLG SLEG + G + L + + + +Q
Sbjct: 1225 ESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQ----P 1280
Query: 435 GDELLEVNEYRLHGLTHSEVVNILKQLPD-RVRLVCARNSIDS 476
GDE+L++ + GLT E NI+K LPD V +V R S+ S
Sbjct: 1281 GDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQS 1323
Score = 39.1 bits (87), Expect = 0.049
Identities = 27/90 (30%), Positives = 42/90 (46%), Gaps = 5/90 (5%)
Query: 10 VEVVELTNDGNGLGFNLVGGRS----TGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNL 65
VEV G GLG L +G+ + + PG VA D RL+ GD ++++ +
Sbjct: 354 VEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPV 413
Query: 66 RGFTSEQVAAVLRQAGP-VVRLLVARPADP 94
T +V +L P V ++V+R DP
Sbjct: 414 HCLTLNEVYTILSHCDPGPVPIIVSRHPDP 443
Score = 37.1 bits (82), Expect = 0.20
Identities = 18/60 (30%), Positives = 35/60 (58%)
Query: 207 GLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVE 266
GLG ++ G GI+VK+I G +A G+++ D I+E++G S+A ++ +++
Sbjct: 226 GLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGGSMAGLTHQDALQ 285
Score = 33.9 bits (74), Expect = 1.8
Identities = 20/57 (35%), Positives = 32/57 (56%), Gaps = 2/57 (3%)
Query: 196 IIHVDLNKNV-YGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEV 251
++ V L K GLGI + V + +SGIFV ++ GS A G+++ D I+E+
Sbjct: 353 MVEVSLQKEAGVGLGIGLCS-VPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEI 408
>AL731868-7|CAI40830.1| 1501|Homo sapiens myeloid/lymphoid or
mixed-lineage leukemia (trithorax homolog, Drosophila);
tra protein.
Length = 1501
Score = 53.6 bits (123), Expect = 2e-06
Identities = 28/85 (32%), Positives = 49/85 (57%), Gaps = 1/85 (1%)
Query: 193 EIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVD 252
E EII V L K G+G+++ ++ GI+VKS+++G +A+ G++ D+++ VD
Sbjct: 670 EPEIITVTLKKQ-NGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVD 728
Query: 253 GISLADKSNPQSVEILRNTGISVHL 277
G SL S ++ E++ T V L
Sbjct: 729 GRSLVGLSQERAAELMTRTSSVVTL 753
Score = 52.8 bits (121), Expect = 4e-06
Identities = 34/103 (33%), Positives = 53/103 (51%), Gaps = 10/103 (9%)
Query: 11 EVVELT-NDGNGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
E++ +T NG+G ++V + G + +K V+ GG AD D RL +GD +L V +
Sbjct: 672 EIITVTLKKQNGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGRS 731
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARPA----DPATALRAPQP 103
L G + E+ A ++ + VV L VA+ AT L P P
Sbjct: 732 LVGLSQERAAELMTRTSSVVTLEVAKQGAIYHGLATLLNQPSP 774
Score = 48.8 bits (111), Expect = 6e-05
Identities = 35/123 (28%), Positives = 60/123 (48%), Gaps = 11/123 (8%)
Query: 376 EEIGSDKEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAG 435
+ + + EI+ +KK G+G+S+ V +G + + Y++SV+ G + G L AG
Sbjct: 665 QPLRKEPEIITVTLKKQNGMGLSI---VAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAG 721
Query: 436 DELLEVNEYRLHGLTHSEVVNILKQLPDRVRL-VCARNSIDSG-------PRPVVNLASD 487
D+LL V+ L GL+ ++ + V L V + +I G P P++ SD
Sbjct: 722 DQLLSVDGRSLVGLSQERAAELMTRTSSVVTLEVAKQGAIYHGLATLLNQPSPMMQRISD 781
Query: 488 REG 490
R G
Sbjct: 782 RRG 784
Score = 41.9 bits (94), Expect = 0.007
Identities = 22/74 (29%), Positives = 44/74 (59%), Gaps = 1/74 (1%)
Query: 550 EDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGV 609
E I + +K G+G SI+ + + I V+S+V GG A+ +G ++ GD+++SV+G
Sbjct: 672 EIITVTLKKQNGMGLSIVAAKG-AGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGR 730
Query: 610 SIQNATLDQAVQAL 623
S+ + ++A + +
Sbjct: 731 SLVGLSQERAAELM 744
>AL731868-3|CAI40826.1| 1612|Homo sapiens myeloid/lymphoid or
mixed-lineage leukemia (trithorax homolog, Drosophila);
tra protein.
Length = 1612
Score = 53.6 bits (123), Expect = 2e-06
Identities = 28/85 (32%), Positives = 49/85 (57%), Gaps = 1/85 (1%)
Query: 193 EIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVD 252
E EII V L K G+G+++ ++ GI+VKS+++G +A+ G++ D+++ VD
Sbjct: 988 EPEIITVTLKKQ-NGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVD 1046
Query: 253 GISLADKSNPQSVEILRNTGISVHL 277
G SL S ++ E++ T V L
Sbjct: 1047 GRSLVGLSQERAAELMTRTSSVVTL 1071
Score = 52.8 bits (121), Expect = 4e-06
Identities = 34/103 (33%), Positives = 53/103 (51%), Gaps = 10/103 (9%)
Query: 11 EVVELT-NDGNGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
E++ +T NG+G ++V + G + +K V+ GG AD D RL +GD +L V +
Sbjct: 990 EIITVTLKKQNGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGRS 1049
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARPA----DPATALRAPQP 103
L G + E+ A ++ + VV L VA+ AT L P P
Sbjct: 1050 LVGLSQERAAELMTRTSSVVTLEVAKQGAIYHGLATLLNQPSP 1092
Score = 48.8 bits (111), Expect = 6e-05
Identities = 35/123 (28%), Positives = 60/123 (48%), Gaps = 11/123 (8%)
Query: 376 EEIGSDKEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAG 435
+ + + EI+ +KK G+G+S+ V +G + + Y++SV+ G + G L AG
Sbjct: 983 QPLRKEPEIITVTLKKQNGMGLSI---VAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAG 1039
Query: 436 DELLEVNEYRLHGLTHSEVVNILKQLPDRVRL-VCARNSIDSG-------PRPVVNLASD 487
D+LL V+ L GL+ ++ + V L V + +I G P P++ SD
Sbjct: 1040 DQLLSVDGRSLVGLSQERAAELMTRTSSVVTLEVAKQGAIYHGLATLLNQPSPMMQRISD 1099
Query: 488 REG 490
R G
Sbjct: 1100 RRG 1102
Score = 41.9 bits (94), Expect = 0.007
Identities = 22/74 (29%), Positives = 44/74 (59%), Gaps = 1/74 (1%)
Query: 550 EDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGV 609
E I + +K G+G SI+ + + I V+S+V GG A+ +G ++ GD+++SV+G
Sbjct: 990 EIITVTLKKQNGMGLSIVAAKG-AGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGR 1048
Query: 610 SIQNATLDQAVQAL 623
S+ + ++A + +
Sbjct: 1049 SLVGLSQERAAELM 1062
>AL731868-2|CAI40825.1| 1665|Homo sapiens myeloid/lymphoid or
mixed-lineage leukemia (trithorax homolog, Drosophila);
tra protein.
Length = 1665
Score = 53.6 bits (123), Expect = 2e-06
Identities = 28/85 (32%), Positives = 49/85 (57%), Gaps = 1/85 (1%)
Query: 193 EIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVD 252
E EII V L K G+G+++ ++ GI+VKS+++G +A+ G++ D+++ VD
Sbjct: 1004 EPEIITVTLKKQ-NGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVD 1062
Query: 253 GISLADKSNPQSVEILRNTGISVHL 277
G SL S ++ E++ T V L
Sbjct: 1063 GRSLVGLSQERAAELMTRTSSVVTL 1087
Score = 52.8 bits (121), Expect = 4e-06
Identities = 34/103 (33%), Positives = 53/103 (51%), Gaps = 10/103 (9%)
Query: 11 EVVELT-NDGNGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
E++ +T NG+G ++V + G + +K V+ GG AD D RL +GD +L V +
Sbjct: 1006 EIITVTLKKQNGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGRS 1065
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARPA----DPATALRAPQP 103
L G + E+ A ++ + VV L VA+ AT L P P
Sbjct: 1066 LVGLSQERAAELMTRTSSVVTLEVAKQGAIYHGLATLLNQPSP 1108
Score = 48.8 bits (111), Expect = 6e-05
Identities = 35/123 (28%), Positives = 60/123 (48%), Gaps = 11/123 (8%)
Query: 376 EEIGSDKEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAG 435
+ + + EI+ +KK G+G+S+ V +G + + Y++SV+ G + G L AG
Sbjct: 999 QPLRKEPEIITVTLKKQNGMGLSI---VAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAG 1055
Query: 436 DELLEVNEYRLHGLTHSEVVNILKQLPDRVRL-VCARNSIDSG-------PRPVVNLASD 487
D+LL V+ L GL+ ++ + V L V + +I G P P++ SD
Sbjct: 1056 DQLLSVDGRSLVGLSQERAAELMTRTSSVVTLEVAKQGAIYHGLATLLNQPSPMMQRISD 1115
Query: 488 REG 490
R G
Sbjct: 1116 RRG 1118
Score = 41.9 bits (94), Expect = 0.007
Identities = 22/74 (29%), Positives = 44/74 (59%), Gaps = 1/74 (1%)
Query: 550 EDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGV 609
E I + +K G+G SI+ + + I V+S+V GG A+ +G ++ GD+++SV+G
Sbjct: 1006 EIITVTLKKQNGMGLSIVAAKG-AGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGR 1064
Query: 610 SIQNATLDQAVQAL 623
S+ + ++A + +
Sbjct: 1065 SLVGLSQERAAELM 1078
>AL731868-1|CAI40824.1| 1824|Homo sapiens myeloid/lymphoid or
mixed-lineage leukemia (trithorax homolog, Drosophila);
tra protein.
Length = 1824
Score = 53.6 bits (123), Expect = 2e-06
Identities = 28/85 (32%), Positives = 49/85 (57%), Gaps = 1/85 (1%)
Query: 193 EIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVD 252
E EII V L K G+G+++ ++ GI+VKS+++G +A+ G++ D+++ VD
Sbjct: 1004 EPEIITVTLKKQ-NGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVD 1062
Query: 253 GISLADKSNPQSVEILRNTGISVHL 277
G SL S ++ E++ T V L
Sbjct: 1063 GRSLVGLSQERAAELMTRTSSVVTL 1087
Score = 52.8 bits (121), Expect = 4e-06
Identities = 34/103 (33%), Positives = 53/103 (51%), Gaps = 10/103 (9%)
Query: 11 EVVELT-NDGNGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
E++ +T NG+G ++V + G + +K V+ GG AD D RL +GD +L V +
Sbjct: 1006 EIITVTLKKQNGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGRS 1065
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARPA----DPATALRAPQP 103
L G + E+ A ++ + VV L VA+ AT L P P
Sbjct: 1066 LVGLSQERAAELMTRTSSVVTLEVAKQGAIYHGLATLLNQPSP 1108
Score = 48.8 bits (111), Expect = 6e-05
Identities = 35/123 (28%), Positives = 60/123 (48%), Gaps = 11/123 (8%)
Query: 376 EEIGSDKEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAG 435
+ + + EI+ +KK G+G+S+ V +G + + Y++SV+ G + G L AG
Sbjct: 999 QPLRKEPEIITVTLKKQNGMGLSI---VAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAG 1055
Query: 436 DELLEVNEYRLHGLTHSEVVNILKQLPDRVRL-VCARNSIDSG-------PRPVVNLASD 487
D+LL V+ L GL+ ++ + V L V + +I G P P++ SD
Sbjct: 1056 DQLLSVDGRSLVGLSQERAAELMTRTSSVVTLEVAKQGAIYHGLATLLNQPSPMMQRISD 1115
Query: 488 REG 490
R G
Sbjct: 1116 RRG 1118
Score = 41.9 bits (94), Expect = 0.007
Identities = 22/74 (29%), Positives = 44/74 (59%), Gaps = 1/74 (1%)
Query: 550 EDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGV 609
E I + +K G+G SI+ + + I V+S+V GG A+ +G ++ GD+++SV+G
Sbjct: 1006 EIITVTLKKQNGMGLSIVAAKG-AGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGR 1064
Query: 610 SIQNATLDQAVQAL 623
S+ + ++A + +
Sbjct: 1065 SLVGLSQERAAELM 1078
>AL161973-1|CAB82312.1| 1410|Homo sapiens hypothetical protein
protein.
Length = 1410
Score = 53.6 bits (123), Expect = 2e-06
Identities = 28/85 (32%), Positives = 49/85 (57%), Gaps = 1/85 (1%)
Query: 193 EIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVD 252
E EII V L K G+G+++ ++ GI+VKS+++G +A+ G++ D+++ VD
Sbjct: 670 EPEIITVTLKKQ-NGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVD 728
Query: 253 GISLADKSNPQSVEILRNTGISVHL 277
G SL S ++ E++ T V L
Sbjct: 729 GRSLVGLSQERAAELMTRTSSVVTL 753
Score = 52.8 bits (121), Expect = 4e-06
Identities = 34/103 (33%), Positives = 53/103 (51%), Gaps = 10/103 (9%)
Query: 11 EVVELT-NDGNGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
E++ +T NG+G ++V + G + +K V+ GG AD D RL +GD +L V +
Sbjct: 672 EIITVTLKKQNGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGRS 731
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARPA----DPATALRAPQP 103
L G + E+ A ++ + VV L VA+ AT L P P
Sbjct: 732 LVGLSQERAAELMTRTSSVVTLEVAKQGAIYHGLATLLNQPSP 774
Score = 48.8 bits (111), Expect = 6e-05
Identities = 35/123 (28%), Positives = 60/123 (48%), Gaps = 11/123 (8%)
Query: 376 EEIGSDKEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAG 435
+ + + EI+ +KK G+G+S+ V +G + + Y++SV+ G + G L AG
Sbjct: 665 QPLRKEPEIITVTLKKQNGMGLSI---VAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAG 721
Query: 436 DELLEVNEYRLHGLTHSEVVNILKQLPDRVRL-VCARNSIDSG-------PRPVVNLASD 487
D+LL V+ L GL+ ++ + V L V + +I G P P++ SD
Sbjct: 722 DQLLSVDGRSLVGLSQERAAELMTRTSSVVTLEVAKQGAIYHGLATLLNQPSPMMQRISD 781
Query: 488 REG 490
R G
Sbjct: 782 RRG 784
Score = 41.9 bits (94), Expect = 0.007
Identities = 22/74 (29%), Positives = 44/74 (59%), Gaps = 1/74 (1%)
Query: 550 EDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGV 609
E I + +K G+G SI+ + + I V+S+V GG A+ +G ++ GD+++SV+G
Sbjct: 672 EIITVTLKKQNGMGLSIVAAKG-AGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGR 730
Query: 610 SIQNATLDQAVQAL 623
S+ + ++A + +
Sbjct: 731 SLVGLSQERAAELM 744
>AL049698-5|CAI42816.1| 1501|Homo sapiens myeloid/lymphoid or
mixed-lineage leukemia (trithorax homolog, Drosophila);
tra protein.
Length = 1501
Score = 53.6 bits (123), Expect = 2e-06
Identities = 28/85 (32%), Positives = 49/85 (57%), Gaps = 1/85 (1%)
Query: 193 EIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVD 252
E EII V L K G+G+++ ++ GI+VKS+++G +A+ G++ D+++ VD
Sbjct: 670 EPEIITVTLKKQ-NGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVD 728
Query: 253 GISLADKSNPQSVEILRNTGISVHL 277
G SL S ++ E++ T V L
Sbjct: 729 GRSLVGLSQERAAELMTRTSSVVTL 753
Score = 52.8 bits (121), Expect = 4e-06
Identities = 34/103 (33%), Positives = 53/103 (51%), Gaps = 10/103 (9%)
Query: 11 EVVELT-NDGNGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
E++ +T NG+G ++V + G + +K V+ GG AD D RL +GD +L V +
Sbjct: 672 EIITVTLKKQNGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGRS 731
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARPA----DPATALRAPQP 103
L G + E+ A ++ + VV L VA+ AT L P P
Sbjct: 732 LVGLSQERAAELMTRTSSVVTLEVAKQGAIYHGLATLLNQPSP 774
Score = 48.8 bits (111), Expect = 6e-05
Identities = 35/123 (28%), Positives = 60/123 (48%), Gaps = 11/123 (8%)
Query: 376 EEIGSDKEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAG 435
+ + + EI+ +KK G+G+S+ V +G + + Y++SV+ G + G L AG
Sbjct: 665 QPLRKEPEIITVTLKKQNGMGLSI---VAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAG 721
Query: 436 DELLEVNEYRLHGLTHSEVVNILKQLPDRVRL-VCARNSIDSG-------PRPVVNLASD 487
D+LL V+ L GL+ ++ + V L V + +I G P P++ SD
Sbjct: 722 DQLLSVDGRSLVGLSQERAAELMTRTSSVVTLEVAKQGAIYHGLATLLNQPSPMMQRISD 781
Query: 488 REG 490
R G
Sbjct: 782 RRG 784
Score = 41.9 bits (94), Expect = 0.007
Identities = 22/74 (29%), Positives = 44/74 (59%), Gaps = 1/74 (1%)
Query: 550 EDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGV 609
E I + +K G+G SI+ + + I V+S+V GG A+ +G ++ GD+++SV+G
Sbjct: 672 EIITVTLKKQNGMGLSIVAAKG-AGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGR 730
Query: 610 SIQNATLDQAVQAL 623
S+ + ++A + +
Sbjct: 731 SLVGLSQERAAELM 744
>AL049698-3|CAI42814.1| 1612|Homo sapiens myeloid/lymphoid or
mixed-lineage leukemia (trithorax homolog, Drosophila);
tra protein.
Length = 1612
Score = 53.6 bits (123), Expect = 2e-06
Identities = 28/85 (32%), Positives = 49/85 (57%), Gaps = 1/85 (1%)
Query: 193 EIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVD 252
E EII V L K G+G+++ ++ GI+VKS+++G +A+ G++ D+++ VD
Sbjct: 988 EPEIITVTLKKQ-NGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVD 1046
Query: 253 GISLADKSNPQSVEILRNTGISVHL 277
G SL S ++ E++ T V L
Sbjct: 1047 GRSLVGLSQERAAELMTRTSSVVTL 1071
Score = 52.8 bits (121), Expect = 4e-06
Identities = 34/103 (33%), Positives = 53/103 (51%), Gaps = 10/103 (9%)
Query: 11 EVVELT-NDGNGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
E++ +T NG+G ++V + G + +K V+ GG AD D RL +GD +L V +
Sbjct: 990 EIITVTLKKQNGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGRS 1049
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARPA----DPATALRAPQP 103
L G + E+ A ++ + VV L VA+ AT L P P
Sbjct: 1050 LVGLSQERAAELMTRTSSVVTLEVAKQGAIYHGLATLLNQPSP 1092
Score = 48.8 bits (111), Expect = 6e-05
Identities = 35/123 (28%), Positives = 60/123 (48%), Gaps = 11/123 (8%)
Query: 376 EEIGSDKEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAG 435
+ + + EI+ +KK G+G+S+ V +G + + Y++SV+ G + G L AG
Sbjct: 983 QPLRKEPEIITVTLKKQNGMGLSI---VAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAG 1039
Query: 436 DELLEVNEYRLHGLTHSEVVNILKQLPDRVRL-VCARNSIDSG-------PRPVVNLASD 487
D+LL V+ L GL+ ++ + V L V + +I G P P++ SD
Sbjct: 1040 DQLLSVDGRSLVGLSQERAAELMTRTSSVVTLEVAKQGAIYHGLATLLNQPSPMMQRISD 1099
Query: 488 REG 490
R G
Sbjct: 1100 RRG 1102
Score = 41.9 bits (94), Expect = 0.007
Identities = 22/74 (29%), Positives = 44/74 (59%), Gaps = 1/74 (1%)
Query: 550 EDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGV 609
E I + +K G+G SI+ + + I V+S+V GG A+ +G ++ GD+++SV+G
Sbjct: 990 EIITVTLKKQNGMGLSIVAAKG-AGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGR 1048
Query: 610 SIQNATLDQAVQAL 623
S+ + ++A + +
Sbjct: 1049 SLVGLSQERAAELM 1062
>AL049698-2|CAI42813.1| 1665|Homo sapiens myeloid/lymphoid or
mixed-lineage leukemia (trithorax homolog, Drosophila);
tra protein.
Length = 1665
Score = 53.6 bits (123), Expect = 2e-06
Identities = 28/85 (32%), Positives = 49/85 (57%), Gaps = 1/85 (1%)
Query: 193 EIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVD 252
E EII V L K G+G+++ ++ GI+VKS+++G +A+ G++ D+++ VD
Sbjct: 1004 EPEIITVTLKKQ-NGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVD 1062
Query: 253 GISLADKSNPQSVEILRNTGISVHL 277
G SL S ++ E++ T V L
Sbjct: 1063 GRSLVGLSQERAAELMTRTSSVVTL 1087
Score = 52.8 bits (121), Expect = 4e-06
Identities = 34/103 (33%), Positives = 53/103 (51%), Gaps = 10/103 (9%)
Query: 11 EVVELT-NDGNGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
E++ +T NG+G ++V + G + +K V+ GG AD D RL +GD +L V +
Sbjct: 1006 EIITVTLKKQNGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGRS 1065
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARPA----DPATALRAPQP 103
L G + E+ A ++ + VV L VA+ AT L P P
Sbjct: 1066 LVGLSQERAAELMTRTSSVVTLEVAKQGAIYHGLATLLNQPSP 1108
Score = 48.8 bits (111), Expect = 6e-05
Identities = 35/123 (28%), Positives = 60/123 (48%), Gaps = 11/123 (8%)
Query: 376 EEIGSDKEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAG 435
+ + + EI+ +KK G+G+S+ V +G + + Y++SV+ G + G L AG
Sbjct: 999 QPLRKEPEIITVTLKKQNGMGLSI---VAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAG 1055
Query: 436 DELLEVNEYRLHGLTHSEVVNILKQLPDRVRL-VCARNSIDSG-------PRPVVNLASD 487
D+LL V+ L GL+ ++ + V L V + +I G P P++ SD
Sbjct: 1056 DQLLSVDGRSLVGLSQERAAELMTRTSSVVTLEVAKQGAIYHGLATLLNQPSPMMQRISD 1115
Query: 488 REG 490
R G
Sbjct: 1116 RRG 1118
Score = 41.9 bits (94), Expect = 0.007
Identities = 22/74 (29%), Positives = 44/74 (59%), Gaps = 1/74 (1%)
Query: 550 EDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGV 609
E I + +K G+G SI+ + + I V+S+V GG A+ +G ++ GD+++SV+G
Sbjct: 1006 EIITVTLKKQNGMGLSIVAAKG-AGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGR 1064
Query: 610 SIQNATLDQAVQAL 623
S+ + ++A + +
Sbjct: 1065 SLVGLSQERAAELM 1078
>AL049698-1|CAI42812.1| 1824|Homo sapiens myeloid/lymphoid or
mixed-lineage leukemia (trithorax homolog, Drosophila);
tra protein.
Length = 1824
Score = 53.6 bits (123), Expect = 2e-06
Identities = 28/85 (32%), Positives = 49/85 (57%), Gaps = 1/85 (1%)
Query: 193 EIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVD 252
E EII V L K G+G+++ ++ GI+VKS+++G +A+ G++ D+++ VD
Sbjct: 1004 EPEIITVTLKKQ-NGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVD 1062
Query: 253 GISLADKSNPQSVEILRNTGISVHL 277
G SL S ++ E++ T V L
Sbjct: 1063 GRSLVGLSQERAAELMTRTSSVVTL 1087
Score = 52.8 bits (121), Expect = 4e-06
Identities = 34/103 (33%), Positives = 53/103 (51%), Gaps = 10/103 (9%)
Query: 11 EVVELT-NDGNGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
E++ +T NG+G ++V + G + +K V+ GG AD D RL +GD +L V +
Sbjct: 1006 EIITVTLKKQNGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGRS 1065
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARPA----DPATALRAPQP 103
L G + E+ A ++ + VV L VA+ AT L P P
Sbjct: 1066 LVGLSQERAAELMTRTSSVVTLEVAKQGAIYHGLATLLNQPSP 1108
Score = 48.8 bits (111), Expect = 6e-05
Identities = 35/123 (28%), Positives = 60/123 (48%), Gaps = 11/123 (8%)
Query: 376 EEIGSDKEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAG 435
+ + + EI+ +KK G+G+S+ V +G + + Y++SV+ G + G L AG
Sbjct: 999 QPLRKEPEIITVTLKKQNGMGLSI---VAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAG 1055
Query: 436 DELLEVNEYRLHGLTHSEVVNILKQLPDRVRL-VCARNSIDSG-------PRPVVNLASD 487
D+LL V+ L GL+ ++ + V L V + +I G P P++ SD
Sbjct: 1056 DQLLSVDGRSLVGLSQERAAELMTRTSSVVTLEVAKQGAIYHGLATLLNQPSPMMQRISD 1115
Query: 488 REG 490
R G
Sbjct: 1116 RRG 1118
Score = 41.9 bits (94), Expect = 0.007
Identities = 22/74 (29%), Positives = 44/74 (59%), Gaps = 1/74 (1%)
Query: 550 EDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGV 609
E I + +K G+G SI+ + + I V+S+V GG A+ +G ++ GD+++SV+G
Sbjct: 1006 EIITVTLKKQNGMGLSIVAAKG-AGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGR 1064
Query: 610 SIQNATLDQAVQAL 623
S+ + ++A + +
Sbjct: 1065 SLVGLSQERAAELM 1078
>AL009178-3|CAI20902.1| 1612|Homo sapiens myeloid/lymphoid or
mixed-lineage leukemia (trithorax homolog, Drosophila);
tra protein.
Length = 1612
Score = 53.6 bits (123), Expect = 2e-06
Identities = 28/85 (32%), Positives = 49/85 (57%), Gaps = 1/85 (1%)
Query: 193 EIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVD 252
E EII V L K G+G+++ ++ GI+VKS+++G +A+ G++ D+++ VD
Sbjct: 988 EPEIITVTLKKQ-NGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVD 1046
Query: 253 GISLADKSNPQSVEILRNTGISVHL 277
G SL S ++ E++ T V L
Sbjct: 1047 GRSLVGLSQERAAELMTRTSSVVTL 1071
Score = 52.8 bits (121), Expect = 4e-06
Identities = 34/103 (33%), Positives = 53/103 (51%), Gaps = 10/103 (9%)
Query: 11 EVVELT-NDGNGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
E++ +T NG+G ++V + G + +K V+ GG AD D RL +GD +L V +
Sbjct: 990 EIITVTLKKQNGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGRS 1049
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARPA----DPATALRAPQP 103
L G + E+ A ++ + VV L VA+ AT L P P
Sbjct: 1050 LVGLSQERAAELMTRTSSVVTLEVAKQGAIYHGLATLLNQPSP 1092
Score = 48.8 bits (111), Expect = 6e-05
Identities = 35/123 (28%), Positives = 60/123 (48%), Gaps = 11/123 (8%)
Query: 376 EEIGSDKEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAG 435
+ + + EI+ +KK G+G+S+ V +G + + Y++SV+ G + G L AG
Sbjct: 983 QPLRKEPEIITVTLKKQNGMGLSI---VAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAG 1039
Query: 436 DELLEVNEYRLHGLTHSEVVNILKQLPDRVRL-VCARNSIDSG-------PRPVVNLASD 487
D+LL V+ L GL+ ++ + V L V + +I G P P++ SD
Sbjct: 1040 DQLLSVDGRSLVGLSQERAAELMTRTSSVVTLEVAKQGAIYHGLATLLNQPSPMMQRISD 1099
Query: 488 REG 490
R G
Sbjct: 1100 RRG 1102
Score = 41.9 bits (94), Expect = 0.007
Identities = 22/74 (29%), Positives = 44/74 (59%), Gaps = 1/74 (1%)
Query: 550 EDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGV 609
E I + +K G+G SI+ + + I V+S+V GG A+ +G ++ GD+++SV+G
Sbjct: 990 EIITVTLKKQNGMGLSIVAAKG-AGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGR 1048
Query: 610 SIQNATLDQAVQAL 623
S+ + ++A + +
Sbjct: 1049 SLVGLSQERAAELM 1062
>AL009178-2|CAI20901.1| 1665|Homo sapiens myeloid/lymphoid or
mixed-lineage leukemia (trithorax homolog, Drosophila);
tra protein.
Length = 1665
Score = 53.6 bits (123), Expect = 2e-06
Identities = 28/85 (32%), Positives = 49/85 (57%), Gaps = 1/85 (1%)
Query: 193 EIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVD 252
E EII V L K G+G+++ ++ GI+VKS+++G +A+ G++ D+++ VD
Sbjct: 1004 EPEIITVTLKKQ-NGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVD 1062
Query: 253 GISLADKSNPQSVEILRNTGISVHL 277
G SL S ++ E++ T V L
Sbjct: 1063 GRSLVGLSQERAAELMTRTSSVVTL 1087
Score = 52.8 bits (121), Expect = 4e-06
Identities = 34/103 (33%), Positives = 53/103 (51%), Gaps = 10/103 (9%)
Query: 11 EVVELT-NDGNGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
E++ +T NG+G ++V + G + +K V+ GG AD D RL +GD +L V +
Sbjct: 1006 EIITVTLKKQNGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGRS 1065
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARPA----DPATALRAPQP 103
L G + E+ A ++ + VV L VA+ AT L P P
Sbjct: 1066 LVGLSQERAAELMTRTSSVVTLEVAKQGAIYHGLATLLNQPSP 1108
Score = 48.8 bits (111), Expect = 6e-05
Identities = 35/123 (28%), Positives = 60/123 (48%), Gaps = 11/123 (8%)
Query: 376 EEIGSDKEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAG 435
+ + + EI+ +KK G+G+S+ V +G + + Y++SV+ G + G L AG
Sbjct: 999 QPLRKEPEIITVTLKKQNGMGLSI---VAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAG 1055
Query: 436 DELLEVNEYRLHGLTHSEVVNILKQLPDRVRL-VCARNSIDSG-------PRPVVNLASD 487
D+LL V+ L GL+ ++ + V L V + +I G P P++ SD
Sbjct: 1056 DQLLSVDGRSLVGLSQERAAELMTRTSSVVTLEVAKQGAIYHGLATLLNQPSPMMQRISD 1115
Query: 488 REG 490
R G
Sbjct: 1116 RRG 1118
Score = 41.9 bits (94), Expect = 0.007
Identities = 22/74 (29%), Positives = 44/74 (59%), Gaps = 1/74 (1%)
Query: 550 EDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGV 609
E I + +K G+G SI+ + + I V+S+V GG A+ +G ++ GD+++SV+G
Sbjct: 1006 EIITVTLKKQNGMGLSIVAAKG-AGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGR 1064
Query: 610 SIQNATLDQAVQAL 623
S+ + ++A + +
Sbjct: 1065 SLVGLSQERAAELM 1078
>AL009178-1|CAI20900.1| 1824|Homo sapiens myeloid/lymphoid or
mixed-lineage leukemia (trithorax homolog, Drosophila);
tra protein.
Length = 1824
Score = 53.6 bits (123), Expect = 2e-06
Identities = 28/85 (32%), Positives = 49/85 (57%), Gaps = 1/85 (1%)
Query: 193 EIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVD 252
E EII V L K G+G+++ ++ GI+VKS+++G +A+ G++ D+++ VD
Sbjct: 1004 EPEIITVTLKKQ-NGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVD 1062
Query: 253 GISLADKSNPQSVEILRNTGISVHL 277
G SL S ++ E++ T V L
Sbjct: 1063 GRSLVGLSQERAAELMTRTSSVVTL 1087
Score = 52.8 bits (121), Expect = 4e-06
Identities = 34/103 (33%), Positives = 53/103 (51%), Gaps = 10/103 (9%)
Query: 11 EVVELT-NDGNGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
E++ +T NG+G ++V + G + +K V+ GG AD D RL +GD +L V +
Sbjct: 1006 EIITVTLKKQNGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGRS 1065
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARPA----DPATALRAPQP 103
L G + E+ A ++ + VV L VA+ AT L P P
Sbjct: 1066 LVGLSQERAAELMTRTSSVVTLEVAKQGAIYHGLATLLNQPSP 1108
Score = 48.8 bits (111), Expect = 6e-05
Identities = 35/123 (28%), Positives = 60/123 (48%), Gaps = 11/123 (8%)
Query: 376 EEIGSDKEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAG 435
+ + + EI+ +KK G+G+S+ V +G + + Y++SV+ G + G L AG
Sbjct: 999 QPLRKEPEIITVTLKKQNGMGLSI---VAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAG 1055
Query: 436 DELLEVNEYRLHGLTHSEVVNILKQLPDRVRL-VCARNSIDSG-------PRPVVNLASD 487
D+LL V+ L GL+ ++ + V L V + +I G P P++ SD
Sbjct: 1056 DQLLSVDGRSLVGLSQERAAELMTRTSSVVTLEVAKQGAIYHGLATLLNQPSPMMQRISD 1115
Query: 488 REG 490
R G
Sbjct: 1116 RRG 1118
Score = 41.9 bits (94), Expect = 0.007
Identities = 22/74 (29%), Positives = 44/74 (59%), Gaps = 1/74 (1%)
Query: 550 EDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGV 609
E I + +K G+G SI+ + + I V+S+V GG A+ +G ++ GD+++SV+G
Sbjct: 1006 EIITVTLKKQNGMGLSIVAAKG-AGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGR 1064
Query: 610 SIQNATLDQAVQAL 623
S+ + ++A + +
Sbjct: 1065 SLVGLSQERAAELM 1078
>AB209420-1|BAD92657.1| 1639|Homo sapiens Afadin variant protein.
Length = 1639
Score = 53.6 bits (123), Expect = 2e-06
Identities = 28/85 (32%), Positives = 49/85 (57%), Gaps = 1/85 (1%)
Query: 193 EIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVD 252
E EII V L K G+G+++ ++ GI+VKS+++G +A+ G++ D+++ VD
Sbjct: 992 EPEIITVTLKKQ-NGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVD 1050
Query: 253 GISLADKSNPQSVEILRNTGISVHL 277
G SL S ++ E++ T V L
Sbjct: 1051 GRSLVGLSQERAAELMTRTSSVVTL 1075
Score = 52.8 bits (121), Expect = 4e-06
Identities = 34/103 (33%), Positives = 53/103 (51%), Gaps = 10/103 (9%)
Query: 11 EVVELT-NDGNGLGFNLVGGRSTG-----VVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
E++ +T NG+G ++V + G + +K V+ GG AD D RL +GD +L V +
Sbjct: 994 EIITVTLKKQNGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGRS 1053
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARPA----DPATALRAPQP 103
L G + E+ A ++ + VV L VA+ AT L P P
Sbjct: 1054 LVGLSQERAAELMTRTSSVVTLEVAKQGAIYHGLATLLNQPSP 1096
Score = 48.8 bits (111), Expect = 6e-05
Identities = 35/123 (28%), Positives = 60/123 (48%), Gaps = 11/123 (8%)
Query: 376 EEIGSDKEILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAG 435
+ + + EI+ +KK G+G+S+ V +G + + Y++SV+ G + G L AG
Sbjct: 987 QPLRKEPEIITVTLKKQNGMGLSI---VAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAG 1043
Query: 436 DELLEVNEYRLHGLTHSEVVNILKQLPDRVRL-VCARNSIDSG-------PRPVVNLASD 487
D+LL V+ L GL+ ++ + V L V + +I G P P++ SD
Sbjct: 1044 DQLLSVDGRSLVGLSQERAAELMTRTSSVVTLEVAKQGAIYHGLATLLNQPSPMMQRISD 1103
Query: 488 REG 490
R G
Sbjct: 1104 RRG 1106
Score = 41.9 bits (94), Expect = 0.007
Identities = 22/74 (29%), Positives = 44/74 (59%), Gaps = 1/74 (1%)
Query: 550 EDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGV 609
E I + +K G+G SI+ + + I V+S+V GG A+ +G ++ GD+++SV+G
Sbjct: 994 EIITVTLKKQNGMGLSIVAAKG-AGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGR 1052
Query: 610 SIQNATLDQAVQAL 623
S+ + ++A + +
Sbjct: 1053 SLVGLSQERAAELM 1066
>D63481-1|BAA09768.3| 1630|Homo sapiens KIAA0147 protein protein.
Length = 1630
Score = 53.2 bits (122), Expect = 3e-06
Identities = 34/96 (35%), Positives = 49/96 (51%), Gaps = 7/96 (7%)
Query: 552 IVMLVKADQGLGFSILDYQD--PVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGV 609
+ L ++++GLGFSI + P I V + GG A + G + GDRV+S+NGV
Sbjct: 862 VACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGV 921
Query: 610 SIQNATLDQAVQALKGAPRGTVKVGIAR----PLPP 641
+ A D AV L A T+ + + R PLPP
Sbjct: 922 DVTEARHDHAVSLLTAA-SPTIALLLEREAGGPLPP 956
Score = 52.4 bits (120), Expect = 5e-06
Identities = 26/89 (29%), Positives = 51/89 (57%), Gaps = 3/89 (3%)
Query: 201 LNKNVYGLGITVAG---YVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLA 257
L ++ GLG ++AG + +GIFV I EG +A ++G +++ DR++ ++G+ +
Sbjct: 865 LARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVT 924
Query: 258 DKSNPQSVEILRNTGISVHLVLERYLRGP 286
+ + +V +L ++ L+LER GP
Sbjct: 925 EARHDHAVSLLTAASPTIALLLEREAGGP 953
Score = 51.6 bits (118), Expect = 9e-06
Identities = 33/81 (40%), Positives = 40/81 (49%), Gaps = 4/81 (4%)
Query: 393 EGLGISLEGTVDVEGGQELRPHH---YIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
E LGIS+ G G P +I V P G G G L G LLEVN+ L GL
Sbjct: 1109 ERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGL 1168
Query: 450 THSEVVNILKQLPDRVR-LVC 469
TH E V +L+ + D + LVC
Sbjct: 1169 THGEAVQLLRSVGDTLTVLVC 1189
Score = 50.4 bits (115), Expect = 2e-05
Identities = 34/113 (30%), Positives = 51/113 (45%), Gaps = 11/113 (9%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRST--------GVVIKYVLPGGVADKDRRLQSGDHVLQV 60
Q V L GLGF++ GG+ + G+ + + GG A + LQ GD VL +
Sbjct: 859 QRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSI 918
Query: 61 GSVNLRGFTSEQVAAVLRQAGPVVRLLVARPAD---PATALRAPQPGTALVPT 110
V++ + ++L A P + LL+ R A P + L P TA V T
Sbjct: 919 NGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVAT 971
Score = 42.3 bits (95), Expect = 0.005
Identities = 28/82 (34%), Positives = 43/82 (52%), Gaps = 7/82 (8%)
Query: 381 DKEILVAEIKKLEGLGISL---EGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDE 437
++E+ + +++ GLGIS+ +G+ +G E +I V +GP GV GD+
Sbjct: 724 EEELTLTILRQTGGLGISIAGGKGSTPYKGDDE---GIFISRVSEEGPAARAGV-RVGDK 779
Query: 438 LLEVNEYRLHGLTHSEVVNILK 459
LLEVN L G H E V L+
Sbjct: 780 LLEVNGVALQGAEHHEAVEALR 801
Score = 40.3 bits (90), Expect = 0.021
Identities = 24/75 (32%), Positives = 42/75 (56%), Gaps = 5/75 (6%)
Query: 553 VMLVKADQGLGFSILDYQD----PVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNG 608
+ L +A LG SI+ D P + + ++P G+A ++G + GDR+++VNG
Sbjct: 1005 IRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNG 1063
Query: 609 VSIQNATLDQAVQAL 623
+++AT +AV AL
Sbjct: 1064 QDVRDATHQEAVSAL 1078
Score = 40.3 bits (90), Expect = 0.021
Identities = 25/78 (32%), Positives = 37/78 (47%), Gaps = 1/78 (1%)
Query: 33 GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVARPA 92
G+ I V P G A +D RL+ G +L+V +L G T + +LR G + +LV
Sbjct: 1133 GIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGF 1192
Query: 93 DPAT-ALRAPQPGTALVP 109
+ +T A PG P
Sbjct: 1193 EASTDAALEVSPGVIANP 1210
Score = 39.9 bits (89), Expect = 0.028
Identities = 32/96 (33%), Positives = 47/96 (48%), Gaps = 12/96 (12%)
Query: 10 VEVVELTNDGNGLGFNLVGG----------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQ 59
VE + L G LG ++VGG + GV I VLP G+A + L+ GD +L
Sbjct: 1002 VEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILA 1060
Query: 60 VGSVNLRGFTSEQVAAVLRQAGPVVRLLVAR-PADP 94
V ++R T ++ + L + + LLV R PA P
Sbjct: 1061 VNGQDVRDATHQEAVSALLRPCLELSLLVRRDPAPP 1096
Score = 39.5 bits (88), Expect = 0.037
Identities = 28/101 (27%), Positives = 54/101 (53%), Gaps = 4/101 (3%)
Query: 547 QSKEDIVMLVKADQGLGFSILDYQD--PVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVM 604
+ +E + +++ GLG SI + P + I + + G A + G + GD+++
Sbjct: 723 EEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLL 781
Query: 605 SVNGVSIQNATLDQAVQALKGAPRGT-VKVGIARPLPPQDS 644
VNGV++Q A +AV+AL+GA ++V R + P+++
Sbjct: 782 EVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENA 822
Score = 35.5 bits (78), Expect = 0.60
Identities = 18/54 (33%), Positives = 29/54 (53%)
Query: 571 DPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
+P DP I + + P G A ++G + G R++ VN S+ T +AVQ L+
Sbjct: 1125 NPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLR 1178
Score = 35.1 bits (77), Expect = 0.79
Identities = 31/100 (31%), Positives = 47/100 (47%), Gaps = 13/100 (13%)
Query: 3 LSTEWAQVEVVELT----NDGNGLGFNLVGGRST--------GVVIKYVLPGGVADKDRR 50
L E A++E ELT GLG ++ GG+ + G+ I V G A +
Sbjct: 715 LLIEPARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAAR-AG 773
Query: 51 LQSGDHVLQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVAR 90
++ GD +L+V V L+G + LR AG V++ V R
Sbjct: 774 VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWR 813
Score = 35.1 bits (77), Expect = 0.79
Identities = 14/49 (28%), Positives = 32/49 (65%)
Query: 224 GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTG 272
GIF+ + +A + G++++ R++EV+ SL ++ ++V++LR+ G
Sbjct: 1133 GIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVG 1181
Score = 34.3 bits (75), Expect = 1.4
Identities = 35/115 (30%), Positives = 47/115 (40%), Gaps = 9/115 (7%)
Query: 395 LGISLEGTVDVE----GGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLT 450
LG+S+ G D G QE P +I VLP G G L GD +L VN + T
Sbjct: 1014 LGLSIVGGSDHSSHPFGVQE--PGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDAT 1070
Query: 451 HSEVVNILKQLPDRVRLVCARNSIDSGPRP--VVNLASDREGFEARKIISGSLNN 503
H E V+ L + + L+ R+ G R + +R G R G N
Sbjct: 1071 HQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGN 1125
Score = 34.3 bits (75), Expect = 1.4
Identities = 15/58 (25%), Positives = 34/58 (58%), Gaps = 1/58 (1%)
Query: 224 GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
G+F+ ++ A +SG +++ DRI+ V+G + D ++ ++V L + + L++ R
Sbjct: 1035 GVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRR 1091
>BC044627-1|AAH44627.1| 682|Homo sapiens SCRIB protein protein.
Length = 682
Score = 53.2 bits (122), Expect = 3e-06
Identities = 34/96 (35%), Positives = 49/96 (51%), Gaps = 7/96 (7%)
Query: 552 IVMLVKADQGLGFSILDYQD--PVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGV 609
+ L ++++GLGFSI + P I V + GG A + G + GDRV+S+NGV
Sbjct: 158 VACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGV 217
Query: 610 SIQNATLDQAVQALKGAPRGTVKVGIAR----PLPP 641
+ A D AV L A T+ + + R PLPP
Sbjct: 218 DVTEARHDHAVSLLTAA-SPTIALLLEREAGGPLPP 252
Score = 52.4 bits (120), Expect = 5e-06
Identities = 26/89 (29%), Positives = 51/89 (57%), Gaps = 3/89 (3%)
Query: 201 LNKNVYGLGITVAG---YVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLA 257
L ++ GLG ++AG + +GIFV I EG +A ++G +++ DR++ ++G+ +
Sbjct: 161 LARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVT 220
Query: 258 DKSNPQSVEILRNTGISVHLVLERYLRGP 286
+ + +V +L ++ L+LER GP
Sbjct: 221 EARHDHAVSLLTAASPTIALLLEREAGGP 249
Score = 51.6 bits (118), Expect = 9e-06
Identities = 33/81 (40%), Positives = 40/81 (49%), Gaps = 4/81 (4%)
Query: 393 EGLGISLEGTVDVEGGQELRPHH---YIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
E LGIS+ G G P +I V P G G G L G LLEVN+ L GL
Sbjct: 405 ERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGL 464
Query: 450 THSEVVNILKQLPDRVR-LVC 469
TH E V +L+ + D + LVC
Sbjct: 465 THGEAVQLLRSVGDTLTVLVC 485
Score = 50.4 bits (115), Expect = 2e-05
Identities = 34/113 (30%), Positives = 51/113 (45%), Gaps = 11/113 (9%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRST--------GVVIKYVLPGGVADKDRRLQSGDHVLQV 60
Q V L GLGF++ GG+ + G+ + + GG A + LQ GD VL +
Sbjct: 155 QRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSI 214
Query: 61 GSVNLRGFTSEQVAAVLRQAGPVVRLLVARPAD---PATALRAPQPGTALVPT 110
V++ + ++L A P + LL+ R A P + L P TA V T
Sbjct: 215 NGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVAT 267
Score = 42.3 bits (95), Expect = 0.005
Identities = 28/82 (34%), Positives = 43/82 (52%), Gaps = 7/82 (8%)
Query: 381 DKEILVAEIKKLEGLGISL---EGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDE 437
++E+ + +++ GLGIS+ +G+ +G E +I V +GP GV GD+
Sbjct: 20 EEELTLTILRQTGGLGISIAGGKGSTPYKGDDE---GIFISRVSEEGPAARAGV-RVGDK 75
Query: 438 LLEVNEYRLHGLTHSEVVNILK 459
LLEVN L G H E V L+
Sbjct: 76 LLEVNGVALQGAEHHEAVEALR 97
Score = 40.3 bits (90), Expect = 0.021
Identities = 24/75 (32%), Positives = 42/75 (56%), Gaps = 5/75 (6%)
Query: 553 VMLVKADQGLGFSILDYQD----PVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNG 608
+ L +A LG SI+ D P + + ++P G+A ++G + GDR+++VNG
Sbjct: 301 IRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNG 359
Query: 609 VSIQNATLDQAVQAL 623
+++AT +AV AL
Sbjct: 360 QDVRDATHQEAVSAL 374
Score = 40.3 bits (90), Expect = 0.021
Identities = 25/78 (32%), Positives = 37/78 (47%), Gaps = 1/78 (1%)
Query: 33 GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVARPA 92
G+ I V P G A +D RL+ G +L+V +L G T + +LR G + +LV
Sbjct: 429 GIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGF 488
Query: 93 DPAT-ALRAPQPGTALVP 109
+ +T A PG P
Sbjct: 489 EASTDAALEVSPGVIANP 506
Score = 39.9 bits (89), Expect = 0.028
Identities = 32/96 (33%), Positives = 47/96 (48%), Gaps = 12/96 (12%)
Query: 10 VEVVELTNDGNGLGFNLVGG----------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQ 59
VE + L G LG ++VGG + GV I VLP G+A + L+ GD +L
Sbjct: 298 VEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILA 356
Query: 60 VGSVNLRGFTSEQVAAVLRQAGPVVRLLVAR-PADP 94
V ++R T ++ + L + + LLV R PA P
Sbjct: 357 VNGQDVRDATHQEAVSALLRPCLELSLLVRRDPAPP 392
Score = 39.5 bits (88), Expect = 0.037
Identities = 28/101 (27%), Positives = 54/101 (53%), Gaps = 4/101 (3%)
Query: 547 QSKEDIVMLVKADQGLGFSILDYQD--PVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVM 604
+ +E + +++ GLG SI + P + I + + G A + G + GD+++
Sbjct: 19 EEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLL 77
Query: 605 SVNGVSIQNATLDQAVQALKGAPRGT-VKVGIARPLPPQDS 644
VNGV++Q A +AV+AL+GA ++V R + P+++
Sbjct: 78 EVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENA 118
Score = 35.5 bits (78), Expect = 0.60
Identities = 18/54 (33%), Positives = 29/54 (53%)
Query: 571 DPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
+P DP I + + P G A ++G + G R++ VN S+ T +AVQ L+
Sbjct: 421 NPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLR 474
Score = 35.1 bits (77), Expect = 0.79
Identities = 31/100 (31%), Positives = 47/100 (47%), Gaps = 13/100 (13%)
Query: 3 LSTEWAQVEVVELT----NDGNGLGFNLVGGRST--------GVVIKYVLPGGVADKDRR 50
L E A++E ELT GLG ++ GG+ + G+ I V G A +
Sbjct: 11 LLIEPARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAAR-AG 69
Query: 51 LQSGDHVLQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVAR 90
++ GD +L+V V L+G + LR AG V++ V R
Sbjct: 70 VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWR 109
Score = 35.1 bits (77), Expect = 0.79
Identities = 14/49 (28%), Positives = 32/49 (65%)
Query: 224 GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTG 272
GIF+ + +A + G++++ R++EV+ SL ++ ++V++LR+ G
Sbjct: 429 GIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVG 477
Score = 34.3 bits (75), Expect = 1.4
Identities = 35/115 (30%), Positives = 47/115 (40%), Gaps = 9/115 (7%)
Query: 395 LGISLEGTVDVE----GGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLT 450
LG+S+ G D G QE P +I VLP G G L GD +L VN + T
Sbjct: 310 LGLSIVGGSDHSSHPFGVQE--PGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDAT 366
Query: 451 HSEVVNILKQLPDRVRLVCARNSIDSGPRP--VVNLASDREGFEARKIISGSLNN 503
H E V+ L + + L+ R+ G R + +R G R G N
Sbjct: 367 HQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGN 421
Score = 34.3 bits (75), Expect = 1.4
Identities = 15/58 (25%), Positives = 34/58 (58%), Gaps = 1/58 (1%)
Query: 224 GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
G+F+ ++ A +SG +++ DRI+ V+G + D ++ ++V L + + L++ R
Sbjct: 331 GVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRR 387
>BC014632-1|AAH14632.2| 832|Homo sapiens SCRIB protein protein.
Length = 832
Score = 53.2 bits (122), Expect = 3e-06
Identities = 34/96 (35%), Positives = 49/96 (51%), Gaps = 7/96 (7%)
Query: 552 IVMLVKADQGLGFSILDYQD--PVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGV 609
+ L ++++GLGFSI + P I V + GG A + G + GDRV+S+NGV
Sbjct: 64 VACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGV 123
Query: 610 SIQNATLDQAVQALKGAPRGTVKVGIAR----PLPP 641
+ A D AV L A T+ + + R PLPP
Sbjct: 124 DVTEARHDHAVSLLTAA-SPTIALLLEREAGGPLPP 158
Score = 52.4 bits (120), Expect = 5e-06
Identities = 26/89 (29%), Positives = 51/89 (57%), Gaps = 3/89 (3%)
Query: 201 LNKNVYGLGITVAG---YVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLA 257
L ++ GLG ++AG + +GIFV I EG +A ++G +++ DR++ ++G+ +
Sbjct: 67 LARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVT 126
Query: 258 DKSNPQSVEILRNTGISVHLVLERYLRGP 286
+ + +V +L ++ L+LER GP
Sbjct: 127 EARHDHAVSLLTAASPTIALLLEREAGGP 155
Score = 51.6 bits (118), Expect = 9e-06
Identities = 33/81 (40%), Positives = 40/81 (49%), Gaps = 4/81 (4%)
Query: 393 EGLGISLEGTVDVEGGQELRPHH---YIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
E LGIS+ G G P +I V P G G G L G LLEVN+ L GL
Sbjct: 311 ERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGL 370
Query: 450 THSEVVNILKQLPDRVR-LVC 469
TH E V +L+ + D + LVC
Sbjct: 371 THGEAVQLLRSVGDTLTVLVC 391
Score = 50.4 bits (115), Expect = 2e-05
Identities = 34/113 (30%), Positives = 51/113 (45%), Gaps = 11/113 (9%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRST--------GVVIKYVLPGGVADKDRRLQSGDHVLQV 60
Q V L GLGF++ GG+ + G+ + + GG A + LQ GD VL +
Sbjct: 61 QRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSI 120
Query: 61 GSVNLRGFTSEQVAAVLRQAGPVVRLLVARPAD---PATALRAPQPGTALVPT 110
V++ + ++L A P + LL+ R A P + L P TA V T
Sbjct: 121 NGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVAT 173
Score = 40.3 bits (90), Expect = 0.021
Identities = 24/75 (32%), Positives = 42/75 (56%), Gaps = 5/75 (6%)
Query: 553 VMLVKADQGLGFSILDYQD----PVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNG 608
+ L +A LG SI+ D P + + ++P G+A ++G + GDR+++VNG
Sbjct: 207 IRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNG 265
Query: 609 VSIQNATLDQAVQAL 623
+++AT +AV AL
Sbjct: 266 QDVRDATHQEAVSAL 280
Score = 40.3 bits (90), Expect = 0.021
Identities = 25/78 (32%), Positives = 37/78 (47%), Gaps = 1/78 (1%)
Query: 33 GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVARPA 92
G+ I V P G A +D RL+ G +L+V +L G T + +LR G + +LV
Sbjct: 335 GIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGF 394
Query: 93 DPAT-ALRAPQPGTALVP 109
+ +T A PG P
Sbjct: 395 EASTDAALEVSPGVIANP 412
Score = 39.9 bits (89), Expect = 0.028
Identities = 32/96 (33%), Positives = 47/96 (48%), Gaps = 12/96 (12%)
Query: 10 VEVVELTNDGNGLGFNLVGG----------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQ 59
VE + L G LG ++VGG + GV I VLP G+A + L+ GD +L
Sbjct: 204 VEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILA 262
Query: 60 VGSVNLRGFTSEQVAAVLRQAGPVVRLLVAR-PADP 94
V ++R T ++ + L + + LLV R PA P
Sbjct: 263 VNGQDVRDATHQEAVSALLRPCLELSLLVRRDPAPP 298
Score = 35.5 bits (78), Expect = 0.60
Identities = 18/54 (33%), Positives = 29/54 (53%)
Query: 571 DPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
+P DP I + + P G A ++G + G R++ VN S+ T +AVQ L+
Sbjct: 327 NPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLR 380
Score = 35.1 bits (77), Expect = 0.79
Identities = 14/49 (28%), Positives = 32/49 (65%)
Query: 224 GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTG 272
GIF+ + +A + G++++ R++EV+ SL ++ ++V++LR+ G
Sbjct: 335 GIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVG 383
Score = 34.3 bits (75), Expect = 1.4
Identities = 35/115 (30%), Positives = 47/115 (40%), Gaps = 9/115 (7%)
Query: 395 LGISLEGTVDVE----GGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLT 450
LG+S+ G D G QE P +I VLP G G L GD +L VN + T
Sbjct: 216 LGLSIVGGSDHSSHPFGVQE--PGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDAT 272
Query: 451 HSEVVNILKQLPDRVRLVCARNSIDSGPRP--VVNLASDREGFEARKIISGSLNN 503
H E V+ L + + L+ R+ G R + +R G R G N
Sbjct: 273 HQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGN 327
Score = 34.3 bits (75), Expect = 1.4
Identities = 15/58 (25%), Positives = 34/58 (58%), Gaps = 1/58 (1%)
Query: 224 GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
G+F+ ++ A +SG +++ DRI+ V+G + D ++ ++V L + + L++ R
Sbjct: 237 GVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRR 293
>AY062238-1|AAL38976.1| 1630|Homo sapiens scribble protein.
Length = 1630
Score = 53.2 bits (122), Expect = 3e-06
Identities = 34/96 (35%), Positives = 49/96 (51%), Gaps = 7/96 (7%)
Query: 552 IVMLVKADQGLGFSILDYQD--PVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGV 609
+ L ++++GLGFSI + P I V + GG A + G + GDRV+S+NGV
Sbjct: 862 VACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGV 921
Query: 610 SIQNATLDQAVQALKGAPRGTVKVGIAR----PLPP 641
+ A D AV L A T+ + + R PLPP
Sbjct: 922 DVTEARHDHAVSLLTAA-SPTIALLLEREAGGPLPP 956
Score = 52.4 bits (120), Expect = 5e-06
Identities = 26/89 (29%), Positives = 51/89 (57%), Gaps = 3/89 (3%)
Query: 201 LNKNVYGLGITVAG---YVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLA 257
L ++ GLG ++AG + +GIFV I EG +A ++G +++ DR++ ++G+ +
Sbjct: 865 LARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVT 924
Query: 258 DKSNPQSVEILRNTGISVHLVLERYLRGP 286
+ + +V +L ++ L+LER GP
Sbjct: 925 EARHDHAVSLLTAASPTIALLLEREAGGP 953
Score = 51.6 bits (118), Expect = 9e-06
Identities = 33/81 (40%), Positives = 40/81 (49%), Gaps = 4/81 (4%)
Query: 393 EGLGISLEGTVDVEGGQELRPHH---YIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
E LGIS+ G G P +I V P G G G L G LLEVN+ L GL
Sbjct: 1109 ERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGL 1168
Query: 450 THSEVVNILKQLPDRVR-LVC 469
TH E V +L+ + D + LVC
Sbjct: 1169 THGEAVQLLRSVGDTLTVLVC 1189
Score = 50.4 bits (115), Expect = 2e-05
Identities = 34/113 (30%), Positives = 51/113 (45%), Gaps = 11/113 (9%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRST--------GVVIKYVLPGGVADKDRRLQSGDHVLQV 60
Q V L GLGF++ GG+ + G+ + + GG A + LQ GD VL +
Sbjct: 859 QRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSI 918
Query: 61 GSVNLRGFTSEQVAAVLRQAGPVVRLLVARPAD---PATALRAPQPGTALVPT 110
V++ + ++L A P + LL+ R A P + L P TA V T
Sbjct: 919 NGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVAT 971
Score = 42.3 bits (95), Expect = 0.005
Identities = 28/82 (34%), Positives = 43/82 (52%), Gaps = 7/82 (8%)
Query: 381 DKEILVAEIKKLEGLGISL---EGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDE 437
++E+ + +++ GLGIS+ +G+ +G E +I V +GP GV GD+
Sbjct: 724 EEELTLTILRQTGGLGISIAGGKGSTPYKGDDE---GIFISRVSEEGPAARAGV-RVGDK 779
Query: 438 LLEVNEYRLHGLTHSEVVNILK 459
LLEVN L G H E V L+
Sbjct: 780 LLEVNGVALQGAEHHEAVEALR 801
Score = 40.3 bits (90), Expect = 0.021
Identities = 24/75 (32%), Positives = 42/75 (56%), Gaps = 5/75 (6%)
Query: 553 VMLVKADQGLGFSILDYQD----PVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNG 608
+ L +A LG SI+ D P + + ++P G+A ++G + GDR+++VNG
Sbjct: 1005 IRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNG 1063
Query: 609 VSIQNATLDQAVQAL 623
+++AT +AV AL
Sbjct: 1064 QDVRDATHQEAVSAL 1078
Score = 40.3 bits (90), Expect = 0.021
Identities = 25/78 (32%), Positives = 37/78 (47%), Gaps = 1/78 (1%)
Query: 33 GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVARPA 92
G+ I V P G A +D RL+ G +L+V +L G T + +LR G + +LV
Sbjct: 1133 GIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGF 1192
Query: 93 DPAT-ALRAPQPGTALVP 109
+ +T A PG P
Sbjct: 1193 EASTDAALEVSPGVIANP 1210
Score = 39.9 bits (89), Expect = 0.028
Identities = 32/96 (33%), Positives = 47/96 (48%), Gaps = 12/96 (12%)
Query: 10 VEVVELTNDGNGLGFNLVGG----------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQ 59
VE + L G LG ++VGG + GV I VLP G+A + L+ GD +L
Sbjct: 1002 VEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILA 1060
Query: 60 VGSVNLRGFTSEQVAAVLRQAGPVVRLLVAR-PADP 94
V ++R T ++ + L + + LLV R PA P
Sbjct: 1061 VNGQDVRDATHQEAVSALLRPCLELSLLVRRDPAPP 1096
Score = 39.5 bits (88), Expect = 0.037
Identities = 28/101 (27%), Positives = 54/101 (53%), Gaps = 4/101 (3%)
Query: 547 QSKEDIVMLVKADQGLGFSILDYQD--PVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVM 604
+ +E + +++ GLG SI + P + I + + G A + G + GD+++
Sbjct: 723 EEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLL 781
Query: 605 SVNGVSIQNATLDQAVQALKGAPRGT-VKVGIARPLPPQDS 644
VNGV++Q A +AV+AL+GA ++V R + P+++
Sbjct: 782 EVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENA 822
Score = 35.5 bits (78), Expect = 0.60
Identities = 18/54 (33%), Positives = 29/54 (53%)
Query: 571 DPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
+P DP I + + P G A ++G + G R++ VN S+ T +AVQ L+
Sbjct: 1125 NPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLR 1178
Score = 35.1 bits (77), Expect = 0.79
Identities = 31/100 (31%), Positives = 47/100 (47%), Gaps = 13/100 (13%)
Query: 3 LSTEWAQVEVVELT----NDGNGLGFNLVGGRST--------GVVIKYVLPGGVADKDRR 50
L E A++E ELT GLG ++ GG+ + G+ I V G A +
Sbjct: 715 LLIEPARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAAR-AG 773
Query: 51 LQSGDHVLQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVAR 90
++ GD +L+V V L+G + LR AG V++ V R
Sbjct: 774 VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWR 813
Score = 35.1 bits (77), Expect = 0.79
Identities = 14/49 (28%), Positives = 32/49 (65%)
Query: 224 GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTG 272
GIF+ + +A + G++++ R++EV+ SL ++ ++V++LR+ G
Sbjct: 1133 GIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVG 1181
Score = 34.3 bits (75), Expect = 1.4
Identities = 35/115 (30%), Positives = 47/115 (40%), Gaps = 9/115 (7%)
Query: 395 LGISLEGTVDVE----GGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLT 450
LG+S+ G D G QE P +I VLP G G L GD +L VN + T
Sbjct: 1014 LGLSIVGGSDHSSHPFGVQE--PGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDAT 1070
Query: 451 HSEVVNILKQLPDRVRLVCARNSIDSGPRP--VVNLASDREGFEARKIISGSLNN 503
H E V+ L + + L+ R+ G R + +R G R G N
Sbjct: 1071 HQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGN 1125
Score = 34.3 bits (75), Expect = 1.4
Identities = 15/58 (25%), Positives = 34/58 (58%), Gaps = 1/58 (1%)
Query: 224 GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
G+F+ ++ A +SG +++ DRI+ V+G + D ++ ++V L + + L++ R
Sbjct: 1035 GVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRR 1091
>AF271734-1|AAP88018.1| 1601|Homo sapiens SCRIB1 variant N1 protein.
Length = 1601
Score = 53.2 bits (122), Expect = 3e-06
Identities = 34/96 (35%), Positives = 49/96 (51%), Gaps = 7/96 (7%)
Query: 552 IVMLVKADQGLGFSILDYQD--PVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGV 609
+ L ++++GLGFSI + P I V + GG A + G + GDRV+S+NGV
Sbjct: 833 VACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGV 892
Query: 610 SIQNATLDQAVQALKGAPRGTVKVGIAR----PLPP 641
+ A D AV L A T+ + + R PLPP
Sbjct: 893 DVTEARHDHAVSLLTAA-SPTIALLLEREAGGPLPP 927
Score = 52.4 bits (120), Expect = 5e-06
Identities = 26/89 (29%), Positives = 51/89 (57%), Gaps = 3/89 (3%)
Query: 201 LNKNVYGLGITVAG---YVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLA 257
L ++ GLG ++AG + +GIFV I EG +A ++G +++ DR++ ++G+ +
Sbjct: 836 LARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVT 895
Query: 258 DKSNPQSVEILRNTGISVHLVLERYLRGP 286
+ + +V +L ++ L+LER GP
Sbjct: 896 EARHDHAVSLLTAASPTIALLLEREAGGP 924
Score = 51.6 bits (118), Expect = 9e-06
Identities = 33/81 (40%), Positives = 40/81 (49%), Gaps = 4/81 (4%)
Query: 393 EGLGISLEGTVDVEGGQELRPHH---YIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
E LGIS+ G G P +I V P G G G L G LLEVN+ L GL
Sbjct: 1080 ERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGL 1139
Query: 450 THSEVVNILKQLPDRVR-LVC 469
TH E V +L+ + D + LVC
Sbjct: 1140 THGEAVQLLRSVGDTLTVLVC 1160
Score = 50.4 bits (115), Expect = 2e-05
Identities = 34/113 (30%), Positives = 51/113 (45%), Gaps = 11/113 (9%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRST--------GVVIKYVLPGGVADKDRRLQSGDHVLQV 60
Q V L GLGF++ GG+ + G+ + + GG A + LQ GD VL +
Sbjct: 830 QRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSI 889
Query: 61 GSVNLRGFTSEQVAAVLRQAGPVVRLLVARPAD---PATALRAPQPGTALVPT 110
V++ + ++L A P + LL+ R A P + L P TA V T
Sbjct: 890 NGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVAT 942
Score = 42.3 bits (95), Expect = 0.005
Identities = 28/82 (34%), Positives = 43/82 (52%), Gaps = 7/82 (8%)
Query: 381 DKEILVAEIKKLEGLGISL---EGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDE 437
++E+ + +++ GLGIS+ +G+ +G E +I V +GP GV GD+
Sbjct: 695 EEELTLTILRQTGGLGISIAGGKGSTPYKGDDE---GIFISRVSEEGPAARAGV-RVGDK 750
Query: 438 LLEVNEYRLHGLTHSEVVNILK 459
LLEVN L G H E V L+
Sbjct: 751 LLEVNGVALQGAEHHEAVEALR 772
Score = 40.3 bits (90), Expect = 0.021
Identities = 24/75 (32%), Positives = 42/75 (56%), Gaps = 5/75 (6%)
Query: 553 VMLVKADQGLGFSILDYQD----PVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNG 608
+ L +A LG SI+ D P + + ++P G+A ++G + GDR+++VNG
Sbjct: 976 IRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNG 1034
Query: 609 VSIQNATLDQAVQAL 623
+++AT +AV AL
Sbjct: 1035 QDVRDATHQEAVSAL 1049
Score = 40.3 bits (90), Expect = 0.021
Identities = 25/78 (32%), Positives = 37/78 (47%), Gaps = 1/78 (1%)
Query: 33 GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVARPA 92
G+ I V P G A +D RL+ G +L+V +L G T + +LR G + +LV
Sbjct: 1104 GIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGF 1163
Query: 93 DPAT-ALRAPQPGTALVP 109
+ +T A PG P
Sbjct: 1164 EASTDAALEVSPGVIANP 1181
Score = 39.9 bits (89), Expect = 0.028
Identities = 32/96 (33%), Positives = 47/96 (48%), Gaps = 12/96 (12%)
Query: 10 VEVVELTNDGNGLGFNLVGG----------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQ 59
VE + L G LG ++VGG + GV I VLP G+A + L+ GD +L
Sbjct: 973 VEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILA 1031
Query: 60 VGSVNLRGFTSEQVAAVLRQAGPVVRLLVAR-PADP 94
V ++R T ++ + L + + LLV R PA P
Sbjct: 1032 VNGQDVRDATHQEAVSALLRPCLELSLLVRRDPAPP 1067
Score = 39.5 bits (88), Expect = 0.037
Identities = 28/101 (27%), Positives = 54/101 (53%), Gaps = 4/101 (3%)
Query: 547 QSKEDIVMLVKADQGLGFSILDYQD--PVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVM 604
+ +E + +++ GLG SI + P + I + + G A + G + GD+++
Sbjct: 694 EEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLL 752
Query: 605 SVNGVSIQNATLDQAVQALKGAPRGT-VKVGIARPLPPQDS 644
VNGV++Q A +AV+AL+GA ++V R + P+++
Sbjct: 753 EVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENA 793
Score = 35.5 bits (78), Expect = 0.60
Identities = 18/54 (33%), Positives = 29/54 (53%)
Query: 571 DPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
+P DP I + + P G A ++G + G R++ VN S+ T +AVQ L+
Sbjct: 1096 NPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLR 1149
Score = 35.1 bits (77), Expect = 0.79
Identities = 31/100 (31%), Positives = 47/100 (47%), Gaps = 13/100 (13%)
Query: 3 LSTEWAQVEVVELT----NDGNGLGFNLVGGRST--------GVVIKYVLPGGVADKDRR 50
L E A++E ELT GLG ++ GG+ + G+ I V G A +
Sbjct: 686 LLIEPARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAAR-AG 744
Query: 51 LQSGDHVLQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVAR 90
++ GD +L+V V L+G + LR AG V++ V R
Sbjct: 745 VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWR 784
Score = 35.1 bits (77), Expect = 0.79
Identities = 14/49 (28%), Positives = 32/49 (65%)
Query: 224 GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTG 272
GIF+ + +A + G++++ R++EV+ SL ++ ++V++LR+ G
Sbjct: 1104 GIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVG 1152
Score = 34.3 bits (75), Expect = 1.4
Identities = 35/115 (30%), Positives = 47/115 (40%), Gaps = 9/115 (7%)
Query: 395 LGISLEGTVDVE----GGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLT 450
LG+S+ G D G QE P +I VLP G G L GD +L VN + T
Sbjct: 985 LGLSIVGGSDHSSHPFGVQE--PGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDAT 1041
Query: 451 HSEVVNILKQLPDRVRLVCARNSIDSGPRP--VVNLASDREGFEARKIISGSLNN 503
H E V+ L + + L+ R+ G R + +R G R G N
Sbjct: 1042 HQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGN 1096
Score = 34.3 bits (75), Expect = 1.4
Identities = 15/58 (25%), Positives = 34/58 (58%), Gaps = 1/58 (1%)
Query: 224 GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
G+F+ ++ A +SG +++ DRI+ V+G + D ++ ++V L + + L++ R
Sbjct: 1006 GVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRR 1062
>AF240677-1|AAP88017.1| 1630|Homo sapiens CRIB1 protein.
Length = 1630
Score = 53.2 bits (122), Expect = 3e-06
Identities = 34/96 (35%), Positives = 49/96 (51%), Gaps = 7/96 (7%)
Query: 552 IVMLVKADQGLGFSILDYQD--PVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGV 609
+ L ++++GLGFSI + P I V + GG A + G + GDRV+S+NGV
Sbjct: 862 VACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGV 921
Query: 610 SIQNATLDQAVQALKGAPRGTVKVGIAR----PLPP 641
+ A D AV L A T+ + + R PLPP
Sbjct: 922 DVTEARHDHAVSLLTAA-SPTIALLLEREAGGPLPP 956
Score = 52.4 bits (120), Expect = 5e-06
Identities = 26/89 (29%), Positives = 51/89 (57%), Gaps = 3/89 (3%)
Query: 201 LNKNVYGLGITVAG---YVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLA 257
L ++ GLG ++AG + +GIFV I EG +A ++G +++ DR++ ++G+ +
Sbjct: 865 LARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVT 924
Query: 258 DKSNPQSVEILRNTGISVHLVLERYLRGP 286
+ + +V +L ++ L+LER GP
Sbjct: 925 EARHDHAVSLLTAASPTIALLLEREAGGP 953
Score = 51.6 bits (118), Expect = 9e-06
Identities = 33/81 (40%), Positives = 40/81 (49%), Gaps = 4/81 (4%)
Query: 393 EGLGISLEGTVDVEGGQELRPHH---YIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
E LGIS+ G G P +I V P G G G L G LLEVN+ L GL
Sbjct: 1109 ERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGL 1168
Query: 450 THSEVVNILKQLPDRVR-LVC 469
TH E V +L+ + D + LVC
Sbjct: 1169 THGEAVQLLRSVGDTLTVLVC 1189
Score = 50.4 bits (115), Expect = 2e-05
Identities = 34/113 (30%), Positives = 51/113 (45%), Gaps = 11/113 (9%)
Query: 9 QVEVVELTNDGNGLGFNLVGGRST--------GVVIKYVLPGGVADKDRRLQSGDHVLQV 60
Q V L GLGF++ GG+ + G+ + + GG A + LQ GD VL +
Sbjct: 859 QRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSI 918
Query: 61 GSVNLRGFTSEQVAAVLRQAGPVVRLLVARPAD---PATALRAPQPGTALVPT 110
V++ + ++L A P + LL+ R A P + L P TA V T
Sbjct: 919 NGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVAT 971
Score = 42.3 bits (95), Expect = 0.005
Identities = 28/82 (34%), Positives = 43/82 (52%), Gaps = 7/82 (8%)
Query: 381 DKEILVAEIKKLEGLGISL---EGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDE 437
++E+ + +++ GLGIS+ +G+ +G E +I V +GP GV GD+
Sbjct: 724 EEELTLTILRQTGGLGISIAGGKGSTPYKGDDE---GIFISRVSEEGPAARAGV-RVGDK 779
Query: 438 LLEVNEYRLHGLTHSEVVNILK 459
LLEVN L G H E V L+
Sbjct: 780 LLEVNGVALQGAEHHEAVEALR 801
Score = 40.3 bits (90), Expect = 0.021
Identities = 24/75 (32%), Positives = 42/75 (56%), Gaps = 5/75 (6%)
Query: 553 VMLVKADQGLGFSILDYQD----PVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNG 608
+ L +A LG SI+ D P + + ++P G+A ++G + GDR+++VNG
Sbjct: 1005 IRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNG 1063
Query: 609 VSIQNATLDQAVQAL 623
+++AT +AV AL
Sbjct: 1064 QDVRDATHQEAVSAL 1078
Score = 40.3 bits (90), Expect = 0.021
Identities = 25/78 (32%), Positives = 37/78 (47%), Gaps = 1/78 (1%)
Query: 33 GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVARPA 92
G+ I V P G A +D RL+ G +L+V +L G T + +LR G + +LV
Sbjct: 1133 GIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGF 1192
Query: 93 DPAT-ALRAPQPGTALVP 109
+ +T A PG P
Sbjct: 1193 EASTDAALEVSPGVIANP 1210
Score = 39.9 bits (89), Expect = 0.028
Identities = 32/96 (33%), Positives = 47/96 (48%), Gaps = 12/96 (12%)
Query: 10 VEVVELTNDGNGLGFNLVGG----------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQ 59
VE + L G LG ++VGG + GV I VLP G+A + L+ GD +L
Sbjct: 1002 VEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILA 1060
Query: 60 VGSVNLRGFTSEQVAAVLRQAGPVVRLLVAR-PADP 94
V ++R T ++ + L + + LLV R PA P
Sbjct: 1061 VNGQDVRDATHQEAVSALLRPCLELSLLVRRDPAPP 1096
Score = 39.5 bits (88), Expect = 0.037
Identities = 28/101 (27%), Positives = 54/101 (53%), Gaps = 4/101 (3%)
Query: 547 QSKEDIVMLVKADQGLGFSILDYQD--PVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVM 604
+ +E + +++ GLG SI + P + I + + G A + G + GD+++
Sbjct: 723 EEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLL 781
Query: 605 SVNGVSIQNATLDQAVQALKGAPRGT-VKVGIARPLPPQDS 644
VNGV++Q A +AV+AL+GA ++V R + P+++
Sbjct: 782 EVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENA 822
Score = 35.5 bits (78), Expect = 0.60
Identities = 18/54 (33%), Positives = 29/54 (53%)
Query: 571 DPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
+P DP I + + P G A ++G + G R++ VN S+ T +AVQ L+
Sbjct: 1125 NPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLR 1178
Score = 35.1 bits (77), Expect = 0.79
Identities = 31/100 (31%), Positives = 47/100 (47%), Gaps = 13/100 (13%)
Query: 3 LSTEWAQVEVVELT----NDGNGLGFNLVGGRST--------GVVIKYVLPGGVADKDRR 50
L E A++E ELT GLG ++ GG+ + G+ I V G A +
Sbjct: 715 LLIEPARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAAR-AG 773
Query: 51 LQSGDHVLQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVAR 90
++ GD +L+V V L+G + LR AG V++ V R
Sbjct: 774 VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWR 813
Score = 35.1 bits (77), Expect = 0.79
Identities = 14/49 (28%), Positives = 32/49 (65%)
Query: 224 GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTG 272
GIF+ + +A + G++++ R++EV+ SL ++ ++V++LR+ G
Sbjct: 1133 GIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVG 1181
Score = 34.3 bits (75), Expect = 1.4
Identities = 35/115 (30%), Positives = 47/115 (40%), Gaps = 9/115 (7%)
Query: 395 LGISLEGTVDVE----GGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLT 450
LG+S+ G D G QE P +I VLP G G L GD +L VN + T
Sbjct: 1014 LGLSIVGGSDHSSHPFGVQE--PGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDAT 1070
Query: 451 HSEVVNILKQLPDRVRLVCARNSIDSGPRP--VVNLASDREGFEARKIISGSLNN 503
H E V+ L + + L+ R+ G R + +R G R G N
Sbjct: 1071 HQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGN 1125
Score = 34.3 bits (75), Expect = 1.4
Identities = 15/58 (25%), Positives = 34/58 (58%), Gaps = 1/58 (1%)
Query: 224 GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
G+F+ ++ A +SG +++ DRI+ V+G + D ++ ++V L + + L++ R
Sbjct: 1035 GVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRR 1091
>AK024507-1|BAB15797.1| 331|Homo sapiens FLJ00117 protein protein.
Length = 331
Score = 52.8 bits (121), Expect = 4e-06
Identities = 31/97 (31%), Positives = 52/97 (53%), Gaps = 7/97 (7%)
Query: 562 LGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQ 621
LG +I ++P DP IV+ L G+AE+ G I GDR++++N VS++ L +A+
Sbjct: 124 LGITISGTEEPFDP----IVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSEAIH 179
Query: 622 ALKGAPRGT---VKVGIARPLPPQDSSKSKGTINVNK 655
L+ A +K + RPL P+ S T + ++
Sbjct: 180 LLQVAGETVTLKIKKQLDRPLLPRKSGSLSETSDADE 216
Score = 44.0 bits (99), Expect = 0.002
Identities = 24/88 (27%), Positives = 49/88 (55%), Gaps = 3/88 (3%)
Query: 199 VDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLAD 258
V+L + LGIT++G +E I + + + AE++G I + DRI+ ++ +SL
Sbjct: 115 VELKRYGGPLGITISG---TEEPFDPIVISGLTKRGLAERTGAIHVGDRILAINNVSLKG 171
Query: 259 KSNPQSVEILRNTGISVHLVLERYLRGP 286
+ +++ +L+ G +V L +++ L P
Sbjct: 172 RPLSEAIHLLQVAGETVTLKIKKQLDRP 199
Score = 43.6 bits (98), Expect = 0.002
Identities = 18/76 (23%), Positives = 41/76 (53%), Gaps = 1/76 (1%)
Query: 577 GTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIA 636
G +++ + G VA + G + PGD++++++ + + N ++ AVQ L+ VK+ I
Sbjct: 38 GEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQC-EDLVKLKIR 96
Query: 637 RPLPPQDSSKSKGTIN 652
+ D ++ G ++
Sbjct: 97 KDEDNSDELETTGAVS 112
Score = 39.9 bits (89), Expect = 0.028
Identities = 26/93 (27%), Positives = 43/93 (46%), Gaps = 2/93 (2%)
Query: 3 LSTEWAQVEVVELTNDGNGLGFNLVGGRST--GVVIKYVLPGGVADKDRRLQSGDHVLQV 60
L T A VEL G LG + G +VI + G+A++ + GD +L +
Sbjct: 105 LETTGAVSYTVELKRYGGPLGITISGTEEPFDPIVISGLTKRGLAERTGAIHVGDRILAI 164
Query: 61 GSVNLRGFTSEQVAAVLRQAGPVVRLLVARPAD 93
+V+L+G + +L+ AG V L + + D
Sbjct: 165 NNVSLKGRPLSEAIHLLQVAGETVTLKIKKQLD 197
Score = 36.7 bits (81), Expect = 0.26
Identities = 25/92 (27%), Positives = 46/92 (50%), Gaps = 3/92 (3%)
Query: 191 LPEIEIIHVDL-NKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRII 249
+P HV L K LGIT++ ++ E + + I +GS A ++G ++ D+++
Sbjct: 8 IPSSGTFHVKLPKKRSVELGITISSASRKRGE--PLIISDIKKGSVAHRTGTLEPGDKLL 65
Query: 250 EVDGISLADKSNPQSVEILRNTGISVHLVLER 281
+D I L + +V+ILR V L + +
Sbjct: 66 AIDNIRLDNCPMEDAVQILRQCEDLVKLKIRK 97
Score = 35.5 bits (78), Expect = 0.60
Identities = 18/69 (26%), Positives = 33/69 (47%)
Query: 30 RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVA 89
R ++I + G VA + L+ GD +L + ++ L E +LRQ +V+L +
Sbjct: 37 RGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCEDLVKLKIR 96
Query: 90 RPADPATAL 98
+ D + L
Sbjct: 97 KDEDNSDEL 105
Score = 34.3 bits (75), Expect = 1.4
Identities = 23/80 (28%), Positives = 37/80 (46%), Gaps = 1/80 (1%)
Query: 398 SLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQ-GVLNAGDELLEVNEYRLHGLTHSEVVN 456
S+E + + R I S + G V + G L GD+LL ++ RL + V
Sbjct: 23 SVELGITISSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQ 82
Query: 457 ILKQLPDRVRLVCARNSIDS 476
IL+Q D V+L ++ +S
Sbjct: 83 ILRQCEDLVKLKIRKDEDNS 102
>BC126311-1|AAI26312.1| 1075|Homo sapiens hypothetical protein
FLJ10324 protein.
Length = 1075
Score = 52.4 bits (120), Expect = 5e-06
Identities = 37/100 (37%), Positives = 52/100 (52%), Gaps = 7/100 (7%)
Query: 4 STE-WAQVEVVELTNDGNGLGFNLVGGRST-----GVVIKYVLPGGVADKDRRLQSGDHV 57
STE + V VEL +GLG L+ G T G+ I+ +LPG A D RL GD +
Sbjct: 967 STEDFCYVFTVELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRI 1026
Query: 58 LQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVARPADPATA 97
L+V +L G + ++R G +R LVA+ +D TA
Sbjct: 1027 LEVNGSSLLGLGYLRAVDLIRHGGKKMRFLVAK-SDVETA 1065
Score = 46.0 bits (104), Expect = 4e-04
Identities = 21/86 (24%), Positives = 49/86 (56%)
Query: 196 IIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGIS 255
+ V+L + GLG+ + + G+++++++ GS A G++ + DRI+EV+G S
Sbjct: 974 VFTVELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSS 1033
Query: 256 LADKSNPQSVEILRNTGISVHLVLER 281
L ++V+++R+ G + ++ +
Sbjct: 1034 LLGLGYLRAVDLIRHGGKKMRFLVAK 1059
Score = 45.6 bits (103), Expect = 6e-04
Identities = 25/86 (29%), Positives = 46/86 (53%), Gaps = 3/86 (3%)
Query: 394 GLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSE 453
GLG+ L + G P YI+++LP P G L+ GD +LEVN L GL +
Sbjct: 985 GLGMGLIDGMHTHLGA---PGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLR 1041
Query: 454 VVNILKQLPDRVRLVCARNSIDSGPR 479
V++++ ++R + A++ +++ +
Sbjct: 1042 AVDLIRHGGKKMRFLVAKSDVETAKK 1067
Score = 38.7 bits (86), Expect = 0.064
Identities = 21/72 (29%), Positives = 37/72 (51%), Gaps = 1/72 (1%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
V L + GLG ++D + +++L+PG A +G +S GDR++ VNG S+
Sbjct: 977 VELERGPSGLGMGLIDGMH-THLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLL 1035
Query: 613 NATLDQAVQALK 624
+AV ++
Sbjct: 1036 GLGYLRAVDLIR 1047
>BC117317-1|AAI17318.1| 1075|Homo sapiens hypothetical protein
FLJ10324 protein.
Length = 1075
Score = 52.4 bits (120), Expect = 5e-06
Identities = 37/100 (37%), Positives = 52/100 (52%), Gaps = 7/100 (7%)
Query: 4 STE-WAQVEVVELTNDGNGLGFNLVGGRST-----GVVIKYVLPGGVADKDRRLQSGDHV 57
STE + V VEL +GLG L+ G T G+ I+ +LPG A D RL GD +
Sbjct: 967 STEDFCYVFTVELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRI 1026
Query: 58 LQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVARPADPATA 97
L+V +L G + ++R G +R LVA+ +D TA
Sbjct: 1027 LEVNGSSLLGLGYLRAVDLIRHGGKKMRFLVAK-SDVETA 1065
Score = 46.0 bits (104), Expect = 4e-04
Identities = 21/86 (24%), Positives = 49/86 (56%)
Query: 196 IIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGIS 255
+ V+L + GLG+ + + G+++++++ GS A G++ + DRI+EV+G S
Sbjct: 974 VFTVELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSS 1033
Query: 256 LADKSNPQSVEILRNTGISVHLVLER 281
L ++V+++R+ G + ++ +
Sbjct: 1034 LLGLGYLRAVDLIRHGGKKMRFLVAK 1059
Score = 45.6 bits (103), Expect = 6e-04
Identities = 25/86 (29%), Positives = 46/86 (53%), Gaps = 3/86 (3%)
Query: 394 GLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSE 453
GLG+ L + G P YI+++LP P G L+ GD +LEVN L GL +
Sbjct: 985 GLGMGLIDGMHTHLGA---PGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLR 1041
Query: 454 VVNILKQLPDRVRLVCARNSIDSGPR 479
V++++ ++R + A++ +++ +
Sbjct: 1042 AVDLIRHGGKKMRFLVAKSDVETAKK 1067
Score = 38.7 bits (86), Expect = 0.064
Identities = 21/72 (29%), Positives = 37/72 (51%), Gaps = 1/72 (1%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
V L + GLG ++D + +++L+PG A +G +S GDR++ VNG S+
Sbjct: 977 VELERGPSGLGMGLIDGMH-THLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLL 1035
Query: 613 NATLDQAVQALK 624
+AV ++
Sbjct: 1036 GLGYLRAVDLIR 1047
>BC029054-1|AAH29054.1| 511|Homo sapiens PDZK7 protein protein.
Length = 511
Score = 52.4 bits (120), Expect = 5e-06
Identities = 40/108 (37%), Positives = 63/108 (58%), Gaps = 9/108 (8%)
Query: 183 ITITVPVEL--PEIEIIH-VDLNKNVYG-LGITVAGYVCEKEELSGIFVKSIIEGSSAEQ 238
I I P+E E +IIH V + K+ G LG +V G E GIFV + EGSSAE+
Sbjct: 68 ILINSPIEANSDESDIIHSVRVEKSPAGRLGFSVRG---GSEHGLGIFVSKVEEGSSAER 124
Query: 239 SGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLERYLRGP 286
+G + + D+I EV+G+SL + +V++L ++ +H+++ R R P
Sbjct: 125 AG-LCVGDKITEVNGLSLESTTMGSAVKVLTSSS-RLHMMVRRMGRVP 170
Score = 45.6 bits (103), Expect = 6e-04
Identities = 27/96 (28%), Positives = 52/96 (54%), Gaps = 5/96 (5%)
Query: 196 IIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGIS 255
I+H+ + + LG + G KE GI+V + G AE++G IK+ D+++ +G+
Sbjct: 210 IVHLYTTSDDFCLGFNIRG---GKEFGLGIYVSKVDHGGLAEENG-IKVGDQVLAANGVR 265
Query: 256 LADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHL 291
D S+ Q+VE+L+ + L ++ R P ++ +
Sbjct: 266 FDDISHSQAVEVLKGQ-THIMLTIKETGRYPAYKEM 300
Score = 41.5 bits (93), Expect = 0.009
Identities = 22/49 (44%), Positives = 31/49 (63%), Gaps = 1/49 (2%)
Query: 577 GTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKG 625
G I V + GG+AE+NG I GD+V++ NGV + + QAV+ LKG
Sbjct: 233 GLGIYVSKVDHGGLAEENG-IKVGDQVLAANGVRFDDISHSQAVEVLKG 280
Score = 39.5 bits (88), Expect = 0.037
Identities = 31/106 (29%), Positives = 53/106 (50%), Gaps = 9/106 (8%)
Query: 549 KEDIVMLVKADQG----LGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVM 604
+ DI+ V+ ++ LGFS+ + +G I V + G AE+ G + GD++
Sbjct: 80 ESDIIHSVRVEKSPAGRLGFSVRGGSE----HGLGIFVSKVEEGSSAERAG-LCVGDKIT 134
Query: 605 SVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPLPPQDSSKSKGT 650
VNG+S+++ T+ AV+ L + R + V +P SK K T
Sbjct: 135 EVNGLSLESTTMGSAVKVLTSSSRLHMMVRRMGRVPGIKFSKEKTT 180
Score = 34.7 bits (76), Expect = 1.0
Identities = 21/65 (32%), Positives = 33/65 (50%), Gaps = 3/65 (4%)
Query: 16 TNDGNGLGFNLVGGR--STGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQV 73
T+D LGFN+ GG+ G+ + V GG+A+ + ++ GD VL V + Q
Sbjct: 216 TSDDFCLGFNIRGGKEFGLGIYVSKVDHGGLAE-ENGIKVGDQVLAANGVRFDDISHSQA 274
Query: 74 AAVLR 78
VL+
Sbjct: 275 VEVLK 279
Score = 33.1 bits (72), Expect = 3.2
Identities = 16/56 (28%), Positives = 29/56 (51%), Gaps = 1/56 (1%)
Query: 404 DVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILK 459
++ GG+E Y+ V G + + + GD++L N R ++HS+ V +LK
Sbjct: 225 NIRGGKEFGLGIYVSKV-DHGGLAEENGIKVGDQVLAANGVRFDDISHSQAVEVLK 279
>BC004919-1|AAH04919.2| 371|Homo sapiens FLJ10324 protein protein.
Length = 371
Score = 52.4 bits (120), Expect = 5e-06
Identities = 37/100 (37%), Positives = 52/100 (52%), Gaps = 7/100 (7%)
Query: 4 STE-WAQVEVVELTNDGNGLGFNLVGGRST-----GVVIKYVLPGGVADKDRRLQSGDHV 57
STE + V VEL +GLG L+ G T G+ I+ +LPG A D RL GD +
Sbjct: 263 STEDFCYVFTVELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRI 322
Query: 58 LQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVARPADPATA 97
L+V +L G + ++R G +R LVA+ +D TA
Sbjct: 323 LEVNGSSLLGLGYLRAVDLIRHGGKKMRFLVAK-SDVETA 361
Score = 46.0 bits (104), Expect = 4e-04
Identities = 21/86 (24%), Positives = 49/86 (56%)
Query: 196 IIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGIS 255
+ V+L + GLG+ + + G+++++++ GS A G++ + DRI+EV+G S
Sbjct: 270 VFTVELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSS 329
Query: 256 LADKSNPQSVEILRNTGISVHLVLER 281
L ++V+++R+ G + ++ +
Sbjct: 330 LLGLGYLRAVDLIRHGGKKMRFLVAK 355
Score = 45.6 bits (103), Expect = 6e-04
Identities = 25/86 (29%), Positives = 46/86 (53%), Gaps = 3/86 (3%)
Query: 394 GLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSE 453
GLG+ L + G P YI+++LP P G L+ GD +LEVN L GL +
Sbjct: 281 GLGMGLIDGMHTHLGA---PGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLR 337
Query: 454 VVNILKQLPDRVRLVCARNSIDSGPR 479
V++++ ++R + A++ +++ +
Sbjct: 338 AVDLIRHGGKKMRFLVAKSDVETAKK 363
Score = 38.7 bits (86), Expect = 0.064
Identities = 21/72 (29%), Positives = 37/72 (51%), Gaps = 1/72 (1%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
V L + GLG ++D + +++L+PG A +G +S GDR++ VNG S+
Sbjct: 273 VELERGPSGLGMGLIDGMH-THLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLL 331
Query: 613 NATLDQAVQALK 624
+AV ++
Sbjct: 332 GLGYLRAVDLIR 343
>AL133215-20|CAI10934.1| 517|Homo sapiens novel protein protein.
Length = 517
Score = 52.4 bits (120), Expect = 5e-06
Identities = 40/108 (37%), Positives = 63/108 (58%), Gaps = 9/108 (8%)
Query: 183 ITITVPVEL--PEIEIIH-VDLNKNVYG-LGITVAGYVCEKEELSGIFVKSIIEGSSAEQ 238
I I P+E E +IIH V + K+ G LG +V G E GIFV + EGSSAE+
Sbjct: 68 ILINSPIEANSDESDIIHSVRVEKSPAGRLGFSVRG---GSEHGLGIFVSKVEEGSSAER 124
Query: 239 SGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLERYLRGP 286
+G + + D+I EV+G+SL + +V++L ++ +H+++ R R P
Sbjct: 125 AG-LCVGDKITEVNGLSLESTTMGSAVKVLTSSS-RLHMMVRRMGRVP 170
Score = 45.6 bits (103), Expect = 6e-04
Identities = 27/96 (28%), Positives = 52/96 (54%), Gaps = 5/96 (5%)
Query: 196 IIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGIS 255
I+H+ + + LG + G KE GI+V + G AE++G IK+ D+++ +G+
Sbjct: 210 IVHLYTTSDDFCLGFNIRG---GKEFGLGIYVSKVDHGGLAEENG-IKVGDQVLAANGVR 265
Query: 256 LADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHL 291
D S+ Q+VE+L+ + L ++ R P ++ +
Sbjct: 266 FDDISHSQAVEVLKGQ-THIMLTIKETGRYPAYKEM 300
Score = 41.5 bits (93), Expect = 0.009
Identities = 22/49 (44%), Positives = 31/49 (63%), Gaps = 1/49 (2%)
Query: 577 GTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKG 625
G I V + GG+AE+NG I GD+V++ NGV + + QAV+ LKG
Sbjct: 233 GLGIYVSKVDHGGLAEENG-IKVGDQVLAANGVRFDDISHSQAVEVLKG 280
Score = 39.5 bits (88), Expect = 0.037
Identities = 31/106 (29%), Positives = 53/106 (50%), Gaps = 9/106 (8%)
Query: 549 KEDIVMLVKADQG----LGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVM 604
+ DI+ V+ ++ LGFS+ + +G I V + G AE+ G + GD++
Sbjct: 80 ESDIIHSVRVEKSPAGRLGFSVRGGSE----HGLGIFVSKVEEGSSAERAG-LCVGDKIT 134
Query: 605 SVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPLPPQDSSKSKGT 650
VNG+S+++ T+ AV+ L + R + V +P SK K T
Sbjct: 135 EVNGLSLESTTMGSAVKVLTSSSRLHMMVRRMGRVPGIKFSKEKTT 180
Score = 34.7 bits (76), Expect = 1.0
Identities = 21/65 (32%), Positives = 33/65 (50%), Gaps = 3/65 (4%)
Query: 16 TNDGNGLGFNLVGGR--STGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQV 73
T+D LGFN+ GG+ G+ + V GG+A+ + ++ GD VL V + Q
Sbjct: 216 TSDDFCLGFNIRGGKEFGLGIYVSKVDHGGLAE-ENGIKVGDQVLAANGVRFDDISHSQA 274
Query: 74 AAVLR 78
VL+
Sbjct: 275 VEVLK 279
Score = 33.1 bits (72), Expect = 3.2
Identities = 16/56 (28%), Positives = 29/56 (51%), Gaps = 1/56 (1%)
Query: 404 DVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILK 459
++ GG+E Y+ V G + + + GD++L N R ++HS+ V +LK
Sbjct: 225 NIRGGKEFGLGIYVSKV-DHGGLAEENGIKVGDQVLAANGVRFDDISHSQAVEVLK 279
>AK026862-1|BAB15577.1| 517|Homo sapiens protein ( Homo sapiens
cDNA: FLJ23209 fis, clone ADSH00512. ).
Length = 517
Score = 52.4 bits (120), Expect = 5e-06
Identities = 40/108 (37%), Positives = 63/108 (58%), Gaps = 9/108 (8%)
Query: 183 ITITVPVEL--PEIEIIH-VDLNKNVYG-LGITVAGYVCEKEELSGIFVKSIIEGSSAEQ 238
I I P+E E +IIH V + K+ G LG +V G E GIFV + EGSSAE+
Sbjct: 68 ILINSPIEANSDESDIIHSVRVEKSPAGRLGFSVRG---GSEHGLGIFVSKVEEGSSAER 124
Query: 239 SGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLERYLRGP 286
+G + + D+I EV+G+SL + +V++L ++ +H+++ R R P
Sbjct: 125 AG-LCVGDKITEVNGLSLESTTMGSAVKVLTSSS-RLHMMVRRMGRVP 170
Score = 45.6 bits (103), Expect = 6e-04
Identities = 27/96 (28%), Positives = 52/96 (54%), Gaps = 5/96 (5%)
Query: 196 IIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGIS 255
I+H+ + + LG + G KE GI+V + G AE++G IK+ D+++ +G+
Sbjct: 210 IVHLYTTSDDFCLGFNIRG---GKEFGLGIYVSKVDHGGLAEENG-IKVGDQVLAANGVR 265
Query: 256 LADKSNPQSVEILRNTGISVHLVLERYLRGPKFEHL 291
D S+ Q+VE+L+ + L ++ R P ++ +
Sbjct: 266 FDDISHSQAVEVLKGQ-THIMLTIKETGRYPAYKEM 300
Score = 41.5 bits (93), Expect = 0.009
Identities = 22/49 (44%), Positives = 31/49 (63%), Gaps = 1/49 (2%)
Query: 577 GTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKG 625
G I V + GG+AE+NG I GD+V++ NGV + + QAV+ LKG
Sbjct: 233 GLGIYVSKVDHGGLAEENG-IKVGDQVLAANGVRFDDISHSQAVEVLKG 280
Score = 39.5 bits (88), Expect = 0.037
Identities = 31/106 (29%), Positives = 53/106 (50%), Gaps = 9/106 (8%)
Query: 549 KEDIVMLVKADQG----LGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVM 604
+ DI+ V+ ++ LGFS+ + +G I V + G AE+ G + GD++
Sbjct: 80 ESDIIHSVRVEKSPAGRLGFSVRGGSE----HGLGIFVSKVEEGSSAERAG-LCVGDKIT 134
Query: 605 SVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPLPPQDSSKSKGT 650
VNG+S+++ T+ AV+ L + R + V +P SK K T
Sbjct: 135 EVNGLSLESTTMGSAVKVLTSSSRLHMMVRRMGRVPGIKFSKEKTT 180
Score = 34.7 bits (76), Expect = 1.0
Identities = 21/65 (32%), Positives = 33/65 (50%), Gaps = 3/65 (4%)
Query: 16 TNDGNGLGFNLVGGR--STGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQV 73
T+D LGFN+ GG+ G+ + V GG+A+ + ++ GD VL V + Q
Sbjct: 216 TSDDFCLGFNIRGGKEFGLGIYVSKVDHGGLAE-ENGIKVGDQVLAANGVRFDDISHSQA 274
Query: 74 AAVLR 78
VL+
Sbjct: 275 VEVLK 279
Score = 33.1 bits (72), Expect = 3.2
Identities = 16/56 (28%), Positives = 29/56 (51%), Gaps = 1/56 (1%)
Query: 404 DVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILK 459
++ GG+E Y+ V G + + + GD++L N R ++HS+ V +LK
Sbjct: 225 NIRGGKEFGLGIYVSKV-DHGGLAEENGIKVGDQVLAANGVRFDDISHSQAVEVLK 279
>AK001186-1|BAA91543.1| 654|Homo sapiens protein ( Homo sapiens
cDNA FLJ10324 fis, clone NT2RM2000567. ).
Length = 654
Score = 52.4 bits (120), Expect = 5e-06
Identities = 37/100 (37%), Positives = 52/100 (52%), Gaps = 7/100 (7%)
Query: 4 STE-WAQVEVVELTNDGNGLGFNLVGGRST-----GVVIKYVLPGGVADKDRRLQSGDHV 57
STE + V VEL +GLG L+ G T G+ I+ +LPG A D RL GD +
Sbjct: 546 STEDFCYVFTVELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRI 605
Query: 58 LQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVARPADPATA 97
L+V +L G + ++R G +R LVA+ +D TA
Sbjct: 606 LEVNGSSLLGLGYLRAVDLIRHGGKKMRFLVAK-SDVETA 644
Score = 46.0 bits (104), Expect = 4e-04
Identities = 21/86 (24%), Positives = 49/86 (56%)
Query: 196 IIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGIS 255
+ V+L + GLG+ + + G+++++++ GS A G++ + DRI+EV+G S
Sbjct: 553 VFTVELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSS 612
Query: 256 LADKSNPQSVEILRNTGISVHLVLER 281
L ++V+++R+ G + ++ +
Sbjct: 613 LLGLGYLRAVDLIRHGGKKMRFLVAK 638
Score = 45.6 bits (103), Expect = 6e-04
Identities = 25/86 (29%), Positives = 46/86 (53%), Gaps = 3/86 (3%)
Query: 394 GLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSE 453
GLG+ L + G P YI+++LP P G L+ GD +LEVN L GL +
Sbjct: 564 GLGMGLIDGMHTHLGA---PGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLR 620
Query: 454 VVNILKQLPDRVRLVCARNSIDSGPR 479
V++++ ++R + A++ +++ +
Sbjct: 621 AVDLIRHGGKKMRFLVAKSDVETAKK 646
Score = 38.7 bits (86), Expect = 0.064
Identities = 21/72 (29%), Positives = 37/72 (51%), Gaps = 1/72 (1%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
V L + GLG ++D + +++L+PG A +G +S GDR++ VNG S+
Sbjct: 556 VELERGPSGLGMGLIDGMH-THLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLL 614
Query: 613 NATLDQAVQALK 624
+AV ++
Sbjct: 615 GLGYLRAVDLIR 626
>AK000997-1|BAA91459.1| 580|Homo sapiens protein ( Homo sapiens
cDNA FLJ10135 fis, clone HEMBA1003117. ).
Length = 580
Score = 52.4 bits (120), Expect = 5e-06
Identities = 37/100 (37%), Positives = 52/100 (52%), Gaps = 7/100 (7%)
Query: 4 STE-WAQVEVVELTNDGNGLGFNLVGGRST-----GVVIKYVLPGGVADKDRRLQSGDHV 57
STE + V VEL +GLG L+ G T G+ I+ +LPG A D RL GD +
Sbjct: 472 STEDFCYVFTVELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRI 531
Query: 58 LQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVARPADPATA 97
L+V +L G + ++R G +R LVA+ +D TA
Sbjct: 532 LEVNGSSLLGLGYLRAVDLIRHGGKKMRFLVAK-SDVETA 570
Score = 46.0 bits (104), Expect = 4e-04
Identities = 21/86 (24%), Positives = 49/86 (56%)
Query: 196 IIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGIS 255
+ V+L + GLG+ + + G+++++++ GS A G++ + DRI+EV+G S
Sbjct: 479 VFTVELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSS 538
Query: 256 LADKSNPQSVEILRNTGISVHLVLER 281
L ++V+++R+ G + ++ +
Sbjct: 539 LLGLGYLRAVDLIRHGGKKMRFLVAK 564
Score = 45.6 bits (103), Expect = 6e-04
Identities = 25/86 (29%), Positives = 46/86 (53%), Gaps = 3/86 (3%)
Query: 394 GLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSE 453
GLG+ L + G P YI+++LP P G L+ GD +LEVN L GL +
Sbjct: 490 GLGMGLIDGMHTHLGA---PGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLR 546
Query: 454 VVNILKQLPDRVRLVCARNSIDSGPR 479
V++++ ++R + A++ +++ +
Sbjct: 547 AVDLIRHGGKKMRFLVAKSDVETAKK 572
Score = 38.7 bits (86), Expect = 0.064
Identities = 21/72 (29%), Positives = 37/72 (51%), Gaps = 1/72 (1%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
V L + GLG ++D + +++L+PG A +G +S GDR++ VNG S+
Sbjct: 482 VELERGPSGLGMGLIDGMH-THLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLL 540
Query: 613 NATLDQAVQALK 624
+AV ++
Sbjct: 541 GLGYLRAVDLIR 552
>AC092610-2|AAS07560.1| 383|Homo sapiens unknown protein.
Length = 383
Score = 52.4 bits (120), Expect = 5e-06
Identities = 37/100 (37%), Positives = 52/100 (52%), Gaps = 7/100 (7%)
Query: 4 STE-WAQVEVVELTNDGNGLGFNLVGGRST-----GVVIKYVLPGGVADKDRRLQSGDHV 57
STE + V VEL +GLG L+ G T G+ I+ +LPG A D RL GD +
Sbjct: 275 STEDFCYVFTVELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRI 334
Query: 58 LQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVARPADPATA 97
L+V +L G + ++R G +R LVA+ +D TA
Sbjct: 335 LEVNGSSLLGLGYLRAVDLIRHGGKKMRFLVAK-SDVETA 373
Score = 46.0 bits (104), Expect = 4e-04
Identities = 21/86 (24%), Positives = 49/86 (56%)
Query: 196 IIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGIS 255
+ V+L + GLG+ + + G+++++++ GS A G++ + DRI+EV+G S
Sbjct: 282 VFTVELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSS 341
Query: 256 LADKSNPQSVEILRNTGISVHLVLER 281
L ++V+++R+ G + ++ +
Sbjct: 342 LLGLGYLRAVDLIRHGGKKMRFLVAK 367
Score = 45.6 bits (103), Expect = 6e-04
Identities = 25/86 (29%), Positives = 46/86 (53%), Gaps = 3/86 (3%)
Query: 394 GLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSE 453
GLG+ L + G P YI+++LP P G L+ GD +LEVN L GL +
Sbjct: 293 GLGMGLIDGMHTHLGA---PGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLR 349
Query: 454 VVNILKQLPDRVRLVCARNSIDSGPR 479
V++++ ++R + A++ +++ +
Sbjct: 350 AVDLIRHGGKKMRFLVAKSDVETAKK 375
Score = 38.7 bits (86), Expect = 0.064
Identities = 21/72 (29%), Positives = 37/72 (51%), Gaps = 1/72 (1%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
V L + GLG ++D + +++L+PG A +G +S GDR++ VNG S+
Sbjct: 285 VELERGPSGLGMGLIDGMH-THLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLL 343
Query: 613 NATLDQAVQALK 624
+AV ++
Sbjct: 344 GLGYLRAVDLIR 355
>AC092610-1|AAS07559.1| 654|Homo sapiens unknown protein.
Length = 654
Score = 52.4 bits (120), Expect = 5e-06
Identities = 37/100 (37%), Positives = 52/100 (52%), Gaps = 7/100 (7%)
Query: 4 STE-WAQVEVVELTNDGNGLGFNLVGGRST-----GVVIKYVLPGGVADKDRRLQSGDHV 57
STE + V VEL +GLG L+ G T G+ I+ +LPG A D RL GD +
Sbjct: 546 STEDFCYVFTVELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRI 605
Query: 58 LQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVARPADPATA 97
L+V +L G + ++R G +R LVA+ +D TA
Sbjct: 606 LEVNGSSLLGLGYLRAVDLIRHGGKKMRFLVAK-SDVETA 644
Score = 46.0 bits (104), Expect = 4e-04
Identities = 21/86 (24%), Positives = 49/86 (56%)
Query: 196 IIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGIS 255
+ V+L + GLG+ + + G+++++++ GS A G++ + DRI+EV+G S
Sbjct: 553 VFTVELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSS 612
Query: 256 LADKSNPQSVEILRNTGISVHLVLER 281
L ++V+++R+ G + ++ +
Sbjct: 613 LLGLGYLRAVDLIRHGGKKMRFLVAK 638
Score = 45.6 bits (103), Expect = 6e-04
Identities = 25/86 (29%), Positives = 46/86 (53%), Gaps = 3/86 (3%)
Query: 394 GLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSE 453
GLG+ L + G P YI+++LP P G L+ GD +LEVN L GL +
Sbjct: 564 GLGMGLIDGMHTHLGA---PGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLR 620
Query: 454 VVNILKQLPDRVRLVCARNSIDSGPR 479
V++++ ++R + A++ +++ +
Sbjct: 621 AVDLIRHGGKKMRFLVAKSDVETAKK 646
Score = 38.7 bits (86), Expect = 0.064
Identities = 21/72 (29%), Positives = 37/72 (51%), Gaps = 1/72 (1%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
V L + GLG ++D + +++L+PG A +G +S GDR++ VNG S+
Sbjct: 556 VELERGPSGLGMGLIDGMH-THLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLL 614
Query: 613 NATLDQAVQALK 624
+AV ++
Sbjct: 615 GLGYLRAVDLIR 626
>AB058752-1|BAB47478.1| 1114|Homo sapiens KIAA1849 protein protein.
Length = 1114
Score = 52.4 bits (120), Expect = 5e-06
Identities = 37/100 (37%), Positives = 52/100 (52%), Gaps = 7/100 (7%)
Query: 4 STE-WAQVEVVELTNDGNGLGFNLVGGRST-----GVVIKYVLPGGVADKDRRLQSGDHV 57
STE + V VEL +GLG L+ G T G+ I+ +LPG A D RL GD +
Sbjct: 1006 STEDFCYVFTVELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRI 1065
Query: 58 LQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVARPADPATA 97
L+V +L G + ++R G +R LVA+ +D TA
Sbjct: 1066 LEVNGSSLLGLGYLRAVDLIRHGGKKMRFLVAK-SDVETA 1104
Score = 46.0 bits (104), Expect = 4e-04
Identities = 21/86 (24%), Positives = 49/86 (56%)
Query: 196 IIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGIS 255
+ V+L + GLG+ + + G+++++++ GS A G++ + DRI+EV+G S
Sbjct: 1013 VFTVELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSS 1072
Query: 256 LADKSNPQSVEILRNTGISVHLVLER 281
L ++V+++R+ G + ++ +
Sbjct: 1073 LLGLGYLRAVDLIRHGGKKMRFLVAK 1098
Score = 45.6 bits (103), Expect = 6e-04
Identities = 25/86 (29%), Positives = 46/86 (53%), Gaps = 3/86 (3%)
Query: 394 GLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSE 453
GLG+ L + G P YI+++LP P G L+ GD +LEVN L GL +
Sbjct: 1024 GLGMGLIDGMHTHLGA---PGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLR 1080
Query: 454 VVNILKQLPDRVRLVCARNSIDSGPR 479
V++++ ++R + A++ +++ +
Sbjct: 1081 AVDLIRHGGKKMRFLVAKSDVETAKK 1106
Score = 38.7 bits (86), Expect = 0.064
Identities = 21/72 (29%), Positives = 37/72 (51%), Gaps = 1/72 (1%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
V L + GLG ++D + +++L+PG A +G +S GDR++ VNG S+
Sbjct: 1016 VELERGPSGLGMGLIDGMH-THLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLL 1074
Query: 613 NATLDQAVQALK 624
+AV ++
Sbjct: 1075 GLGYLRAVDLIR 1086
>U82108-1|AAB53042.1| 326|Homo sapiens SIP-1 protein.
Length = 326
Score = 52.0 bits (119), Expect = 6e-06
Identities = 59/217 (27%), Positives = 95/217 (43%), Gaps = 26/217 (11%)
Query: 408 GQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRL 467
G++ R +IR V P P L AGD L+EVN + G TH +VV +K + + RL
Sbjct: 27 GEKGRRGQFIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGETHHQVVQRIKAVEGQTRL 85
Query: 468 VCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTSSTATLTNH 527
+ VV+ +D E R++ L A T ++
Sbjct: 86 L------------VVDQETDEE-LRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHS 132
Query: 528 SEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVP 587
SE KK VSG + + + + L K QG GF++ + D P +RS+ P
Sbjct: 133 SEAGKKD-----VSG-PLRELRPRLCHLRKGPQGYGFNL--HSDKSRPGQ---YIRSVDP 181
Query: 588 GGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
G A ++G + DR++ VNG +++ + V ++K
Sbjct: 182 GSPAARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIK 217
Score = 49.6 bits (113), Expect = 3e-05
Identities = 27/57 (47%), Positives = 32/57 (56%), Gaps = 1/57 (1%)
Query: 412 RPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLV 468
RP YIRSV P P G L A D L+EVN + GL H+EVV +K D RL+
Sbjct: 171 RPGQYIRSVDPGSPAARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLL 226
Score = 39.5 bits (88), Expect = 0.037
Identities = 26/75 (34%), Positives = 38/75 (50%), Gaps = 2/75 (2%)
Query: 15 LTNDGNGLGFNLVGGRST-GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQV 73
L G GF+L G + G I+ V PG A+ L++GD +++V VN+ G T QV
Sbjct: 14 LVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGETHHQV 72
Query: 74 AAVLRQAGPVVRLLV 88
++ RLLV
Sbjct: 73 VQRIKAVEGQTRLLV 87
Score = 37.5 bits (83), Expect = 0.15
Identities = 25/70 (35%), Positives = 36/70 (51%), Gaps = 6/70 (8%)
Query: 555 LVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNA 614
LV+ +QG GF + G I R + PG AE + GDR++ VNGV+++
Sbjct: 14 LVRGEQGYGFHL---HGEKGRRGQFI--RRVEPGSPAEA-AALRAGDRLVEVNGVNVEGE 67
Query: 615 TLDQAVQALK 624
T Q VQ +K
Sbjct: 68 THHQVVQRIK 77
Score = 31.5 bits (68), Expect = 9.7
Identities = 13/46 (28%), Positives = 31/46 (67%), Gaps = 1/46 (2%)
Query: 224 GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILR 269
G F++ + GS AE + ++ DR++EV+G+++ +++ Q V+ ++
Sbjct: 33 GQFIRRVEPGSPAEAAA-LRAGDRLVEVNGVNVEGETHHQVVQRIK 77
>BC106001-1|AAI06002.1| 337|Homo sapiens SLC9A3R2 protein protein.
Length = 337
Score = 52.0 bits (119), Expect = 6e-06
Identities = 59/217 (27%), Positives = 95/217 (43%), Gaps = 26/217 (11%)
Query: 408 GQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRL 467
G++ R +IR V P P L AGD L+EVN + G TH +VV +K + + RL
Sbjct: 27 GEKGRRGQFIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGETHHQVVQRIKAVEGQTRL 85
Query: 468 VCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTSSTATLTNH 527
+ VV+ +D E R++ L A T ++
Sbjct: 86 L------------VVDQETDEE-LRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHS 132
Query: 528 SEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVP 587
SE KK VSG + + + + L K QG GF++ + D P +RS+ P
Sbjct: 133 SEAGKKD-----VSG-PLRELRPRLCHLRKGPQGYGFNL--HSDKSRPGQ---YIRSVDP 181
Query: 588 GGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
G A ++G + DR++ VNG +++ + V ++K
Sbjct: 182 GSPAARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIK 217
Score = 49.6 bits (113), Expect = 3e-05
Identities = 27/57 (47%), Positives = 32/57 (56%), Gaps = 1/57 (1%)
Query: 412 RPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLV 468
RP YIRSV P P G L A D L+EVN + GL H+EVV +K D RL+
Sbjct: 171 RPGQYIRSVDPGSPAARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLL 226
Score = 39.5 bits (88), Expect = 0.037
Identities = 26/75 (34%), Positives = 38/75 (50%), Gaps = 2/75 (2%)
Query: 15 LTNDGNGLGFNLVGGRST-GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQV 73
L G GF+L G + G I+ V PG A+ L++GD +++V VN+ G T QV
Sbjct: 14 LVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGETHHQV 72
Query: 74 AAVLRQAGPVVRLLV 88
++ RLLV
Sbjct: 73 VQRIKAVEGQTRLLV 87
Score = 37.5 bits (83), Expect = 0.15
Identities = 25/70 (35%), Positives = 36/70 (51%), Gaps = 6/70 (8%)
Query: 555 LVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNA 614
LV+ +QG GF + G I R + PG AE + GDR++ VNGV+++
Sbjct: 14 LVRGEQGYGFHL---HGEKGRRGQFI--RRVEPGSPAEA-AALRAGDRLVEVNGVNVEGE 67
Query: 615 TLDQAVQALK 624
T Q VQ +K
Sbjct: 68 THHQVVQRIK 77
Score = 31.5 bits (68), Expect = 9.7
Identities = 13/46 (28%), Positives = 31/46 (67%), Gaps = 1/46 (2%)
Query: 224 GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILR 269
G F++ + GS AE + ++ DR++EV+G+++ +++ Q V+ ++
Sbjct: 33 GQFIRRVEPGSPAEAAA-LRAGDRLVEVNGVNVEGETHHQVVQRIK 77
>BC069014-1|AAH69014.1| 372|Homo sapiens SLC9A3R2 protein protein.
Length = 372
Score = 52.0 bits (119), Expect = 6e-06
Identities = 59/217 (27%), Positives = 95/217 (43%), Gaps = 26/217 (11%)
Query: 408 GQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRL 467
G++ R +IR V P P L AGD L+EVN + G TH +VV +K + + RL
Sbjct: 62 GEKGRRGQFIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGETHHQVVQRIKAVEGQTRL 120
Query: 468 VCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTSSTATLTNH 527
+ VV+ +D E R++ L A T ++
Sbjct: 121 L------------VVDQETDEE-LRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHS 167
Query: 528 SEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVP 587
SE KK VSG + + + + L K QG GF++ + D P +RS+ P
Sbjct: 168 SEAGKKD-----VSG-PLRELRPRLCHLRKGPQGYGFNL--HSDKSRPGQ---YIRSVDP 216
Query: 588 GGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
G A ++G + DR++ VNG +++ + V ++K
Sbjct: 217 GSPAARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIK 252
Score = 49.6 bits (113), Expect = 3e-05
Identities = 27/57 (47%), Positives = 32/57 (56%), Gaps = 1/57 (1%)
Query: 412 RPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLV 468
RP YIRSV P P G L A D L+EVN + GL H+EVV +K D RL+
Sbjct: 206 RPGQYIRSVDPGSPAARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLL 261
Score = 39.5 bits (88), Expect = 0.037
Identities = 26/75 (34%), Positives = 38/75 (50%), Gaps = 2/75 (2%)
Query: 15 LTNDGNGLGFNLVGGRST-GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQV 73
L G GF+L G + G I+ V PG A+ L++GD +++V VN+ G T QV
Sbjct: 49 LVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGETHHQV 107
Query: 74 AAVLRQAGPVVRLLV 88
++ RLLV
Sbjct: 108 VQRIKAVEGQTRLLV 122
Score = 37.5 bits (83), Expect = 0.15
Identities = 25/70 (35%), Positives = 36/70 (51%), Gaps = 6/70 (8%)
Query: 555 LVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNA 614
LV+ +QG GF + G I R + PG AE + GDR++ VNGV+++
Sbjct: 49 LVRGEQGYGFHL---HGEKGRRGQFI--RRVEPGSPAEA-AALRAGDRLVEVNGVNVEGE 102
Query: 615 TLDQAVQALK 624
T Q VQ +K
Sbjct: 103 THHQVVQRIK 112
Score = 31.5 bits (68), Expect = 9.7
Identities = 13/46 (28%), Positives = 31/46 (67%), Gaps = 1/46 (2%)
Query: 224 GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILR 269
G F++ + GS AE + ++ DR++EV+G+++ +++ Q V+ ++
Sbjct: 68 GQFIRRVEPGSPAEAAA-LRAGDRLVEVNGVNVEGETHHQVVQRIK 112
>BC014513-1|AAH14513.2| 374|Homo sapiens SLC9A3R2 protein protein.
Length = 374
Score = 52.0 bits (119), Expect = 6e-06
Identities = 59/217 (27%), Positives = 95/217 (43%), Gaps = 26/217 (11%)
Query: 408 GQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRL 467
G++ R +IR V P P L AGD L+EVN + G TH +VV +K + + RL
Sbjct: 64 GEKGRRGQFIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGETHHQVVQRIKAVEGQTRL 122
Query: 468 VCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTSSTATLTNH 527
+ VV+ +D E R++ L A T ++
Sbjct: 123 L------------VVDQETDEE-LRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHS 169
Query: 528 SEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVP 587
SE KK VSG + + + + L K QG GF++ + D P +RS+ P
Sbjct: 170 SEAGKKD-----VSG-PLRELRPRLCHLRKGPQGYGFNL--HSDKSRPGQ---YIRSVDP 218
Query: 588 GGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
G A ++G + DR++ VNG +++ + V ++K
Sbjct: 219 GSPAARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIK 254
Score = 49.6 bits (113), Expect = 3e-05
Identities = 27/57 (47%), Positives = 32/57 (56%), Gaps = 1/57 (1%)
Query: 412 RPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLV 468
RP YIRSV P P G L A D L+EVN + GL H+EVV +K D RL+
Sbjct: 208 RPGQYIRSVDPGSPAARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLL 263
Score = 39.5 bits (88), Expect = 0.037
Identities = 26/75 (34%), Positives = 38/75 (50%), Gaps = 2/75 (2%)
Query: 15 LTNDGNGLGFNLVGGRST-GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQV 73
L G GF+L G + G I+ V PG A+ L++GD +++V VN+ G T QV
Sbjct: 51 LVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGETHHQV 109
Query: 74 AAVLRQAGPVVRLLV 88
++ RLLV
Sbjct: 110 VQRIKAVEGQTRLLV 124
Score = 37.5 bits (83), Expect = 0.15
Identities = 25/70 (35%), Positives = 36/70 (51%), Gaps = 6/70 (8%)
Query: 555 LVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNA 614
LV+ +QG GF + G I R + PG AE + GDR++ VNGV+++
Sbjct: 51 LVRGEQGYGFHL---HGEKGRRGQFI--RRVEPGSPAEA-AALRAGDRLVEVNGVNVEGE 104
Query: 615 TLDQAVQALK 624
T Q VQ +K
Sbjct: 105 THHQVVQRIK 114
Score = 31.5 bits (68), Expect = 9.7
Identities = 13/46 (28%), Positives = 31/46 (67%), Gaps = 1/46 (2%)
Query: 224 GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILR 269
G F++ + GS AE + ++ DR++EV+G+++ +++ Q V+ ++
Sbjct: 70 GQFIRRVEPGSPAEAAA-LRAGDRLVEVNGVNVEGETHHQVVQRIK 114
>AF035771-1|AAC52090.1| 337|Homo sapiens Na+/H+ exchanger
regulatory factor 2 protein.
Length = 337
Score = 52.0 bits (119), Expect = 6e-06
Identities = 59/217 (27%), Positives = 95/217 (43%), Gaps = 26/217 (11%)
Query: 408 GQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRL 467
G++ R +IR V P P L AGD L+EVN + G TH +VV +K + + RL
Sbjct: 27 GEKGRRGQFIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGETHHQVVQRIKAVEGQTRL 85
Query: 468 VCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTSSTATLTNH 527
+ VV+ +D E R++ L A T ++
Sbjct: 86 L------------VVDQETDEE-LRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHS 132
Query: 528 SEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVP 587
SE KK VSG + + + + L K QG GF++ + D P +RS+ P
Sbjct: 133 SEAGKKD-----VSG-PLRELRPRLCHLRKGPQGYGFNL--HSDKSRPGQ---YIRSVDP 181
Query: 588 GGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
G A ++G + DR++ VNG +++ + V ++K
Sbjct: 182 GSPAARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIK 217
Score = 49.6 bits (113), Expect = 3e-05
Identities = 27/57 (47%), Positives = 32/57 (56%), Gaps = 1/57 (1%)
Query: 412 RPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLV 468
RP YIRSV P P G L A D L+EVN + GL H+EVV +K D RL+
Sbjct: 171 RPGQYIRSVDPGSPAARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLL 226
Score = 39.5 bits (88), Expect = 0.037
Identities = 26/75 (34%), Positives = 38/75 (50%), Gaps = 2/75 (2%)
Query: 15 LTNDGNGLGFNLVGGRST-GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQV 73
L G GF+L G + G I+ V PG A+ L++GD +++V VN+ G T QV
Sbjct: 14 LVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGETHHQV 72
Query: 74 AAVLRQAGPVVRLLV 88
++ RLLV
Sbjct: 73 VQRIKAVEGQTRLLV 87
Score = 37.5 bits (83), Expect = 0.15
Identities = 25/70 (35%), Positives = 36/70 (51%), Gaps = 6/70 (8%)
Query: 555 LVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNA 614
LV+ +QG GF + G I R + PG AE + GDR++ VNGV+++
Sbjct: 14 LVRGEQGYGFHL---HGEKGRRGQFI--RRVEPGSPAEA-AALRAGDRLVEVNGVNVEGE 67
Query: 615 TLDQAVQALK 624
T Q VQ +K
Sbjct: 68 THHQVVQRIK 77
Score = 31.5 bits (68), Expect = 9.7
Identities = 13/46 (28%), Positives = 31/46 (67%), Gaps = 1/46 (2%)
Query: 224 GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILR 269
G F++ + GS AE + ++ DR++EV+G+++ +++ Q V+ ++
Sbjct: 33 GQFIRRVEPGSPAEAAA-LRAGDRLVEVNGVNVEGETHHQVVQRIK 77
>AF004900-1|AAC63061.1| 337|Homo sapiens E3KARP protein.
Length = 337
Score = 52.0 bits (119), Expect = 6e-06
Identities = 59/217 (27%), Positives = 95/217 (43%), Gaps = 26/217 (11%)
Query: 408 GQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRL 467
G++ R +IR V P P L AGD L+EVN + G TH +VV +K + + RL
Sbjct: 27 GEKGRRGQFIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGETHHQVVQRIKAVEGQTRL 85
Query: 468 VCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTSSTATLTNH 527
+ VV+ +D E R++ L A T ++
Sbjct: 86 L------------VVDQETDEE-LRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHS 132
Query: 528 SEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVP 587
SE KK VSG + + + + L K QG GF++ + D P +RS+ P
Sbjct: 133 SEAGKKD-----VSG-PLRELRPRLCHLRKGPQGYGFNL--HSDKSRPGQ---YIRSVDP 181
Query: 588 GGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
G A ++G + DR++ VNG +++ + V ++K
Sbjct: 182 GSPAARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIK 217
Score = 49.6 bits (113), Expect = 3e-05
Identities = 27/57 (47%), Positives = 32/57 (56%), Gaps = 1/57 (1%)
Query: 412 RPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLV 468
RP YIRSV P P G L A D L+EVN + GL H+EVV +K D RL+
Sbjct: 171 RPGQYIRSVDPGSPAARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLL 226
Score = 39.5 bits (88), Expect = 0.037
Identities = 26/75 (34%), Positives = 38/75 (50%), Gaps = 2/75 (2%)
Query: 15 LTNDGNGLGFNLVGGRST-GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQV 73
L G GF+L G + G I+ V PG A+ L++GD +++V VN+ G T QV
Sbjct: 14 LVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGETHHQV 72
Query: 74 AAVLRQAGPVVRLLV 88
++ RLLV
Sbjct: 73 VQRIKAVEGQTRLLV 87
Score = 37.5 bits (83), Expect = 0.15
Identities = 25/70 (35%), Positives = 36/70 (51%), Gaps = 6/70 (8%)
Query: 555 LVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNA 614
LV+ +QG GF + G I R + PG AE + GDR++ VNGV+++
Sbjct: 14 LVRGEQGYGFHL---HGEKGRRGQFI--RRVEPGSPAEA-AALRAGDRLVEVNGVNVEGE 67
Query: 615 TLDQAVQALK 624
T Q VQ +K
Sbjct: 68 THHQVVQRIK 77
Score = 31.5 bits (68), Expect = 9.7
Identities = 13/46 (28%), Positives = 31/46 (67%), Gaps = 1/46 (2%)
Query: 224 GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILR 269
G F++ + GS AE + ++ DR++EV+G+++ +++ Q V+ ++
Sbjct: 33 GQFIRRVEPGSPAEAAA-LRAGDRLVEVNGVNVEGETHHQVVQRIK 77
>AC005600-1|AAC34208.1| 337|Homo sapiens Na+/H+ exchanger
regulatory factor 2 protein.
Length = 337
Score = 52.0 bits (119), Expect = 6e-06
Identities = 59/217 (27%), Positives = 95/217 (43%), Gaps = 26/217 (11%)
Query: 408 GQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRL 467
G++ R +IR V P P L AGD L+EVN + G TH +VV +K + + RL
Sbjct: 27 GEKGRRGQFIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGETHHQVVQRIKAVEGQTRL 85
Query: 468 VCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTSSTATLTNH 527
+ VV+ +D E R++ L A T ++
Sbjct: 86 L------------VVDQETDEE-LRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHS 132
Query: 528 SEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVP 587
SE KK VSG + + + + L K QG GF++ + D P +RS+ P
Sbjct: 133 SEAGKKD-----VSG-PLRELRPRLCHLRKGPQGYGFNL--HSDKSRPGQ---YIRSVDP 181
Query: 588 GGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
G A ++G + DR++ VNG +++ + V ++K
Sbjct: 182 GSPAARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIK 217
Score = 49.6 bits (113), Expect = 3e-05
Identities = 27/57 (47%), Positives = 32/57 (56%), Gaps = 1/57 (1%)
Query: 412 RPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLV 468
RP YIRSV P P G L A D L+EVN + GL H+EVV +K D RL+
Sbjct: 171 RPGQYIRSVDPGSPAARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLL 226
Score = 39.5 bits (88), Expect = 0.037
Identities = 26/75 (34%), Positives = 38/75 (50%), Gaps = 2/75 (2%)
Query: 15 LTNDGNGLGFNLVGGRST-GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQV 73
L G GF+L G + G I+ V PG A+ L++GD +++V VN+ G T QV
Sbjct: 14 LVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGETHHQV 72
Query: 74 AAVLRQAGPVVRLLV 88
++ RLLV
Sbjct: 73 VQRIKAVEGQTRLLV 87
Score = 37.5 bits (83), Expect = 0.15
Identities = 25/70 (35%), Positives = 36/70 (51%), Gaps = 6/70 (8%)
Query: 555 LVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNA 614
LV+ +QG GF + G I R + PG AE + GDR++ VNGV+++
Sbjct: 14 LVRGEQGYGFHL---HGEKGRRGQFI--RRVEPGSPAEA-AALRAGDRLVEVNGVNVEGE 67
Query: 615 TLDQAVQALK 624
T Q VQ +K
Sbjct: 68 THHQVVQRIK 77
Score = 31.5 bits (68), Expect = 9.7
Identities = 13/46 (28%), Positives = 31/46 (67%), Gaps = 1/46 (2%)
Query: 224 GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILR 269
G F++ + GS AE + ++ DR++EV+G+++ +++ Q V+ ++
Sbjct: 33 GQFIRRVEPGSPAEAAA-LRAGDRLVEVNGVNVEGETHHQVVQRIK 77
>AC004808-1|AAC23438.1| 434|Homo sapiens unknown protein.
Length = 434
Score = 52.0 bits (119), Expect = 6e-06
Identities = 24/89 (26%), Positives = 53/89 (59%), Gaps = 3/89 (3%)
Query: 193 EIEIIHVDLNKNVYGLGITVAGYVCEKEELSGIFVKSIIEGSSAEQSGKIKINDRIIEVD 252
+ + VD+ K G G ++ G +E ++V + E A ++G++++ D+IIE++
Sbjct: 341 DFDYFTVDMEKGAKGFGFSIRG---GREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEIN 397
Query: 253 GISLADKSNPQSVEILRNTGISVHLVLER 281
G S D ++ +++E++++ G V L+L+R
Sbjct: 398 GESTRDMTHARAIELIKSGGRRVRLLLKR 426
Score = 49.2 bits (112), Expect = 5e-05
Identities = 55/215 (25%), Positives = 97/215 (45%), Gaps = 25/215 (11%)
Query: 417 IRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLP--DRVRLVCARNSI 474
I +V+ G G L+ GDEL+ V+ + G TH V++++ +V L R +
Sbjct: 3 IGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRKVL 62
Query: 475 DSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTSSTATLTNHSEQSKKS 534
G N S GS++ T +SD + T+S NH+ S +
Sbjct: 63 CGGEPCPENGRSP-----------GSVS--THHSSPRSDYATYTNS-----NHAAPSSNA 104
Query: 535 RSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIV---VRSLVPGGVA 591
E + ++ S D+V+ K ++G GF I+ + + T+ V + ++ G A
Sbjct: 105 SPPEGFASHSLQTS--DVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPA 162
Query: 592 EKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGA 626
++ ++ GDR+++VNG SI N V+ +K A
Sbjct: 163 DRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDA 197
Score = 47.6 bits (108), Expect = 1e-04
Identities = 20/69 (28%), Positives = 37/69 (53%)
Query: 405 VEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDR 464
+ GG+E + Y+ + DGP G + GD+++E+N +TH+ + ++K R
Sbjct: 360 IRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKSGGRR 419
Query: 465 VRLVCARNS 473
VRL+ R +
Sbjct: 420 VRLLLKRGT 428
Score = 42.7 bits (96), Expect = 0.004
Identities = 18/48 (37%), Positives = 34/48 (70%)
Query: 230 IIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHL 277
II+GS A++ K+K+ DRI+ V+G S+ + + V+++++ G+SV L
Sbjct: 156 IIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTL 203
Score = 40.3 bits (90), Expect = 0.021
Identities = 23/81 (28%), Positives = 43/81 (53%), Gaps = 4/81 (4%)
Query: 13 VELTNDGNGLGFNLVGGRSTGVVIKYVL---PGGVADKDRRLQSGDHVLQVGSVNLRGFT 69
V++ G GF++ GGR + + YVL G A ++ R++ GD ++++ + R T
Sbjct: 347 VDMEKGAKGFGFSIRGGREYKMDL-YVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMT 405
Query: 70 SEQVAAVLRQAGPVVRLLVAR 90
+ +++ G VRLL+ R
Sbjct: 406 HARAIELIKSGGRRVRLLLKR 426
Score = 36.3 bits (80), Expect = 0.34
Identities = 19/84 (22%), Positives = 46/84 (54%), Gaps = 6/84 (7%)
Query: 580 IVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPR-GTVKVGIARP 638
I++ +++ G A+++G + PGD ++ V+G+ + T + + A R G V + + R
Sbjct: 1 ILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRK 60
Query: 639 L-----PPQDSSKSKGTINVNKAS 657
+ P ++ +S G+++ + +S
Sbjct: 61 VLCGGEPCPENGRSPGSVSTHHSS 84
Score = 35.5 bits (78), Expect = 0.60
Identities = 19/76 (25%), Positives = 36/76 (47%), Gaps = 1/76 (1%)
Query: 385 LVAEIKKLEGLGISLEGTVD-VEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNE 443
+V K+ EG G + +++ E G + H I ++ P L GD +L VN
Sbjct: 120 VVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNG 179
Query: 444 YRLHGLTHSEVVNILK 459
+ + H+++V ++K
Sbjct: 180 QSIINMPHADIVKLIK 195
Score = 35.5 bits (78), Expect = 0.60
Identities = 23/77 (29%), Positives = 41/77 (53%), Gaps = 6/77 (7%)
Query: 553 VMLVKADQGLGFSILDYQD-PVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSI 611
V + K +G GFSI ++ +D + V L G A +NG + GD+++ +NG S
Sbjct: 347 VDMEKGAKGFGFSIRGGREYKMD-----LYVLRLAEDGPAIRNGRMRVGDQIIEINGEST 401
Query: 612 QNATLDQAVQALKGAPR 628
++ T +A++ +K R
Sbjct: 402 RDMTHARAIELIKSGGR 418
>AB016243-1|BAA33216.1| 337|Homo sapiens regulatory factor 2 of
sodium/hydrogen exchanger isoform A3 protein.
Length = 337
Score = 52.0 bits (119), Expect = 6e-06
Identities = 59/217 (27%), Positives = 95/217 (43%), Gaps = 26/217 (11%)
Query: 408 GQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRL 467
G++ R +IR V P P L AGD L+EVN + G TH +VV +K + + RL
Sbjct: 27 GEKGRRGQFIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGETHHQVVQRIKAVEGQTRL 85
Query: 468 VCARNSIDSGPRPVVNLASDREGFEARKIISGSLNNLTTLVKAQSDTSINTSSTATLTNH 527
+ VV+ +D E R++ L A T ++
Sbjct: 86 L------------VVDQETDEE-LRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHS 132
Query: 528 SEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVP 587
SE KK VSG + + + + L K QG GF++ + D P +RS+ P
Sbjct: 133 SEAGKKD-----VSG-PLRELRPRLCHLRKGPQGYGFNL--HSDKSRPGQ---YIRSVDP 181
Query: 588 GGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
G A ++G + DR++ VNG +++ + V ++K
Sbjct: 182 GSPAARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIK 217
Score = 49.6 bits (113), Expect = 3e-05
Identities = 27/57 (47%), Positives = 32/57 (56%), Gaps = 1/57 (1%)
Query: 412 RPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSEVVNILKQLPDRVRLV 468
RP YIRSV P P G L A D L+EVN + GL H+EVV +K D RL+
Sbjct: 171 RPGQYIRSVDPGSPAARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLL 226
Score = 39.5 bits (88), Expect = 0.037
Identities = 26/75 (34%), Positives = 38/75 (50%), Gaps = 2/75 (2%)
Query: 15 LTNDGNGLGFNLVGGRST-GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQV 73
L G GF+L G + G I+ V PG A+ L++GD +++V VN+ G T QV
Sbjct: 14 LVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGETHHQV 72
Query: 74 AAVLRQAGPVVRLLV 88
++ RLLV
Sbjct: 73 VQRIKAVEGQTRLLV 87
Score = 37.5 bits (83), Expect = 0.15
Identities = 25/70 (35%), Positives = 36/70 (51%), Gaps = 6/70 (8%)
Query: 555 LVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNA 614
LV+ +QG GF + G I R + PG AE + GDR++ VNGV+++
Sbjct: 14 LVRGEQGYGFHL---HGEKGRRGQFI--RRVEPGSPAEA-AALRAGDRLVEVNGVNVEGE 67
Query: 615 TLDQAVQALK 624
T Q VQ +K
Sbjct: 68 THHQVVQRIK 77
Score = 31.5 bits (68), Expect = 9.7
Identities = 13/46 (28%), Positives = 31/46 (67%), Gaps = 1/46 (2%)
Query: 224 GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILR 269
G F++ + GS AE + ++ DR++EV+G+++ +++ Q V+ ++
Sbjct: 33 GQFIRRVEPGSPAEAAA-LRAGDRLVEVNGVNVEGETHHQVVQRIK 77
>U82972-1|AAB58261.1| 631|Homo sapiens interleukin-16 protein.
Length = 631
Score = 51.6 bits (118), Expect = 9e-06
Identities = 28/81 (34%), Positives = 44/81 (54%), Gaps = 4/81 (4%)
Query: 18 DGNGLGFNLVGG---RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVA 74
+G GLGF+L GG + + + V P G+A ++ +Q G+ VL + +L+G T
Sbjct: 419 EGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDAL 478
Query: 75 AVLRQA-GPVVRLLVARPADP 94
A+LRQA P ++V R P
Sbjct: 479 AILRQAREPRQAVIVTRKLTP 499
Score = 49.2 bits (112), Expect = 5e-05
Identities = 45/165 (27%), Positives = 76/165 (46%), Gaps = 13/165 (7%)
Query: 325 TEIEPEPESNTTIDSSVLEVGD--LQEPTQEELDQRFDEILAVDKEDIVKKWKEEIGSDK 382
TE E + + D S L+ G + + EEL + +E+ +D+ + K+ G
Sbjct: 357 TEGLTEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATL----KQLDGIHV 412
Query: 383 EILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVN 442
IL E + GLG SL G D+E + + H V P+G +G + G+E+L +N
Sbjct: 413 TILHKE--EGAGLGFSLAGGADLEN-KVITVHR----VFPNGLASQEGTIQKGNEVLSIN 465
Query: 443 EYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASD 487
L G TH + + IL+Q + + V + P +N ++D
Sbjct: 466 GKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTD 510
Score = 48.0 bits (109), Expect = 1e-04
Identities = 28/82 (34%), Positives = 41/82 (50%), Gaps = 3/82 (3%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLGFS+ D VI V + P G+A + G I G+ V+S+NG S++ T A+
Sbjct: 422 GLGFSLAG---GADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDAL 478
Query: 621 QALKGAPRGTVKVGIARPLPPQ 642
L+ A V + R L P+
Sbjct: 479 AILRQAREPRQAVIVTRKLTPE 500
Score = 43.6 bits (98), Expect = 0.002
Identities = 24/85 (28%), Positives = 43/85 (50%), Gaps = 1/85 (1%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
V L K GLGFS+ + + + + + R + G +E++ + PGD ++ + G ++Q
Sbjct: 534 VTLEKMSAGLGFSLEGGKGSLHGDKPLTINR-IFKGAASEQSETVQPGDEILQLGGTAMQ 592
Query: 613 NATLDQAVQALKGAPRGTVKVGIAR 637
T +A +K P G V + I R
Sbjct: 593 GLTRFEAWNIIKALPDGPVTIVIRR 617
Score = 41.5 bits (93), Expect = 0.009
Identities = 27/89 (30%), Positives = 44/89 (49%), Gaps = 7/89 (7%)
Query: 2 VLSTEWAQVEVVELTNDGNGLGFNLVGGRST-----GVVIKYVLPGGVADKDRRLQSGDH 56
V ST A V V L GLGF+L GG+ + + I + G +++ +Q GD
Sbjct: 523 VESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDE 582
Query: 57 VLQVGSVNLRGFTSEQVAAVLRQA--GPV 83
+LQ+G ++G T + +++ GPV
Sbjct: 583 ILQLGGTAMQGLTRFEAWNIIKALPDGPV 611
Score = 40.7 bits (91), Expect = 0.016
Identities = 31/103 (30%), Positives = 50/103 (48%), Gaps = 7/103 (6%)
Query: 377 EIGSDKEILVAEIKKLE-GLGISLEGTV-DVEGGQELRPHHYIRSVLPDGPVGLQGVLNA 434
E ++ + ++K+ GLG SLEG + G + L + + + +Q
Sbjct: 524 ESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQ----P 579
Query: 435 GDELLEVNEYRLHGLTHSEVVNILKQLPD-RVRLVCARNSIDS 476
GDE+L++ + GLT E NI+K LPD V +V R S+ S
Sbjct: 580 GDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQS 622
>S81601-1|AAB36371.2| 374|Homo sapiens prIL-16 protein.
Length = 374
Score = 51.6 bits (118), Expect = 9e-06
Identities = 28/81 (34%), Positives = 44/81 (54%), Gaps = 4/81 (4%)
Query: 18 DGNGLGFNLVGG---RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVA 74
+G GLGF+L GG + + + V P G+A ++ +Q G+ VL + +L+G T
Sbjct: 162 EGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDAL 221
Query: 75 AVLRQA-GPVVRLLVARPADP 94
A+LRQA P ++V R P
Sbjct: 222 AILRQAREPRQAVIVTRKLTP 242
Score = 49.2 bits (112), Expect = 5e-05
Identities = 45/165 (27%), Positives = 76/165 (46%), Gaps = 13/165 (7%)
Query: 325 TEIEPEPESNTTIDSSVLEVGD--LQEPTQEELDQRFDEILAVDKEDIVKKWKEEIGSDK 382
TE E + + D S L+ G + + EEL + +E+ +D+ + K+ G
Sbjct: 100 TEGLTEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATL----KQLDGIHV 155
Query: 383 EILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVN 442
IL E + GLG SL G D+E + + H V P+G +G + G+E+L +N
Sbjct: 156 TILHKE--EGAGLGFSLAGGADLEN-KVITVHR----VFPNGLASQEGTIQKGNEVLSIN 208
Query: 443 EYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASD 487
L G TH + + IL+Q + + V + P +N ++D
Sbjct: 209 GKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTD 253
Score = 48.0 bits (109), Expect = 1e-04
Identities = 28/82 (34%), Positives = 41/82 (50%), Gaps = 3/82 (3%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLGFS+ D VI V + P G+A + G I G+ V+S+NG S++ T A+
Sbjct: 165 GLGFSLAG---GADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDAL 221
Query: 621 QALKGAPRGTVKVGIARPLPPQ 642
L+ A V + R L P+
Sbjct: 222 AILRQAREPRQAVIVTRKLTPE 243
Score = 43.6 bits (98), Expect = 0.002
Identities = 24/85 (28%), Positives = 43/85 (50%), Gaps = 1/85 (1%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
V L K GLGFS+ + + + + + R + G +E++ + PGD ++ + G ++Q
Sbjct: 277 VTLEKMSAGLGFSLEGGKGSLHGDKPLTINR-IFKGAASEQSETVQPGDEILQLGGTAMQ 335
Query: 613 NATLDQAVQALKGAPRGTVKVGIAR 637
T +A +K P G V + I R
Sbjct: 336 GLTRFEAWNIIKALPDGPVTIVIRR 360
Score = 41.5 bits (93), Expect = 0.009
Identities = 27/89 (30%), Positives = 44/89 (49%), Gaps = 7/89 (7%)
Query: 2 VLSTEWAQVEVVELTNDGNGLGFNLVGGRST-----GVVIKYVLPGGVADKDRRLQSGDH 56
V ST A V V L GLGF+L GG+ + + I + G +++ +Q GD
Sbjct: 266 VESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDE 325
Query: 57 VLQVGSVNLRGFTSEQVAAVLRQA--GPV 83
+LQ+G ++G T + +++ GPV
Sbjct: 326 ILQLGGTAMQGLTRFEAWNIIKALPDGPV 354
Score = 40.7 bits (91), Expect = 0.016
Identities = 31/103 (30%), Positives = 50/103 (48%), Gaps = 7/103 (6%)
Query: 377 EIGSDKEILVAEIKKLE-GLGISLEGTV-DVEGGQELRPHHYIRSVLPDGPVGLQGVLNA 434
E ++ + ++K+ GLG SLEG + G + L + + + +Q
Sbjct: 267 ESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQ----P 322
Query: 435 GDELLEVNEYRLHGLTHSEVVNILKQLPD-RVRLVCARNSIDS 476
GDE+L++ + GLT E NI+K LPD V +V R S+ S
Sbjct: 323 GDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQS 365
>M90391-1|AAD04636.1| 631|Homo sapiens putative IL-16 protein
precursor protein.
Length = 631
Score = 51.6 bits (118), Expect = 9e-06
Identities = 28/81 (34%), Positives = 44/81 (54%), Gaps = 4/81 (4%)
Query: 18 DGNGLGFNLVGG---RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVA 74
+G GLGF+L GG + + + V P G+A ++ +Q G+ VL + +L+G T
Sbjct: 419 EGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDAL 478
Query: 75 AVLRQA-GPVVRLLVARPADP 94
A+LRQA P ++V R P
Sbjct: 479 AILRQAREPRQAVIVTRKLTP 499
Score = 49.2 bits (112), Expect = 5e-05
Identities = 45/165 (27%), Positives = 76/165 (46%), Gaps = 13/165 (7%)
Query: 325 TEIEPEPESNTTIDSSVLEVGD--LQEPTQEELDQRFDEILAVDKEDIVKKWKEEIGSDK 382
TE E + + D S L+ G + + EEL + +E+ +D+ + K+ G
Sbjct: 357 TEGLTEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATL----KQLDGIHV 412
Query: 383 EILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVN 442
IL E + GLG SL G D+E + + H V P+G +G + G+E+L +N
Sbjct: 413 TILHKE--EGAGLGFSLAGGADLEN-KVITVHR----VFPNGLASQEGTIQKGNEVLSIN 465
Query: 443 EYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASD 487
L G TH + + IL+Q + + V + P +N ++D
Sbjct: 466 GKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTD 510
Score = 48.0 bits (109), Expect = 1e-04
Identities = 28/82 (34%), Positives = 41/82 (50%), Gaps = 3/82 (3%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLGFS+ D VI V + P G+A + G I G+ V+S+NG S++ T A+
Sbjct: 422 GLGFSLAG---GADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDAL 478
Query: 621 QALKGAPRGTVKVGIARPLPPQ 642
L+ A V + R L P+
Sbjct: 479 AILRQAREPRQAVIVTRKLTPE 500
Score = 43.6 bits (98), Expect = 0.002
Identities = 24/85 (28%), Positives = 43/85 (50%), Gaps = 1/85 (1%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
V L K GLGFS+ + + + + + R + G +E++ + PGD ++ + G ++Q
Sbjct: 534 VTLEKMSAGLGFSLEGGKGSLHGDKPLTINR-IFKGAASEQSETVQPGDEILQLGGTAMQ 592
Query: 613 NATLDQAVQALKGAPRGTVKVGIAR 637
T +A +K P G V + I R
Sbjct: 593 GLTRFEAWNIIKALPDGPVTIVIRR 617
Score = 41.5 bits (93), Expect = 0.009
Identities = 27/89 (30%), Positives = 44/89 (49%), Gaps = 7/89 (7%)
Query: 2 VLSTEWAQVEVVELTNDGNGLGFNLVGGRST-----GVVIKYVLPGGVADKDRRLQSGDH 56
V ST A V V L GLGF+L GG+ + + I + G +++ +Q GD
Sbjct: 523 VESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDE 582
Query: 57 VLQVGSVNLRGFTSEQVAAVLRQA--GPV 83
+LQ+G ++G T + +++ GPV
Sbjct: 583 ILQLGGTAMQGLTRFEAWNIIKALPDGPV 611
Score = 40.7 bits (91), Expect = 0.016
Identities = 31/103 (30%), Positives = 50/103 (48%), Gaps = 7/103 (6%)
Query: 377 EIGSDKEILVAEIKKLE-GLGISLEGTV-DVEGGQELRPHHYIRSVLPDGPVGLQGVLNA 434
E ++ + ++K+ GLG SLEG + G + L + + + +Q
Sbjct: 524 ESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQ----P 579
Query: 435 GDELLEVNEYRLHGLTHSEVVNILKQLPD-RVRLVCARNSIDS 476
GDE+L++ + GLT E NI+K LPD V +V R S+ S
Sbjct: 580 GDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQS 622
>BX005072-4|CAI23643.1| 261|Homo sapiens PDZ domain containing 5A
protein.
Length = 261
Score = 51.6 bits (118), Expect = 9e-06
Identities = 30/90 (33%), Positives = 49/90 (54%), Gaps = 3/90 (3%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPN--GTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVS 610
V L K GLGFS + + + ++ ++ L PG AE+NG I+ GD +++VNG S
Sbjct: 32 VKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 91
Query: 611 IQNATLDQAVQALKGAPRGTVKVGIARPLP 640
+ + + L+GAP+ V + + RP P
Sbjct: 92 TEGLIFQEVLHLLRGAPQ-EVTLLLCRPPP 120
Score = 41.5 bits (93), Expect = 0.009
Identities = 29/87 (33%), Positives = 45/87 (51%), Gaps = 8/87 (9%)
Query: 13 VELTNDGNGLGFNLVGG--------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V+L + NGLGF+ V +S V IK + PG A+++ + +GD +L V +
Sbjct: 32 VKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 91
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARP 91
G ++V +LR A V LL+ RP
Sbjct: 92 TEGLIFQEVLHLLRGAPQEVTLLLCRP 118
Score = 33.5 bits (73), Expect = 2.4
Identities = 28/88 (31%), Positives = 40/88 (45%), Gaps = 7/88 (7%)
Query: 199 VDLNKNVYGLGITVAGYVCEKEELSG-----IFVKSIIEGSSAEQSGKIKINDRIIEVDG 253
V L KN GLG + EKE S + +K + G AE++G I D I+ V+G
Sbjct: 32 VKLKKNANGLGFSFVQM--EKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNG 89
Query: 254 ISLADKSNPQSVEILRNTGISVHLVLER 281
S + + +LR V L+L R
Sbjct: 90 RSTEGLIFQEVLHLLRGAPQEVTLLLCR 117
>BC110798-1|AAI10799.1| 320|Homo sapiens FRMPD2 related 1 protein.
Length = 320
Score = 51.6 bits (118), Expect = 9e-06
Identities = 30/90 (33%), Positives = 49/90 (54%), Gaps = 3/90 (3%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPN--GTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVS 610
V L K GLGFS + + + ++ ++ L PG AE+NG I+ GD +++VNG S
Sbjct: 91 VKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 150
Query: 611 IQNATLDQAVQALKGAPRGTVKVGIARPLP 640
+ + + L+GAP+ V + + RP P
Sbjct: 151 TEGLIFQEVLHLLRGAPQ-EVTLLLCRPPP 179
Score = 41.5 bits (93), Expect = 0.009
Identities = 29/87 (33%), Positives = 45/87 (51%), Gaps = 8/87 (9%)
Query: 13 VELTNDGNGLGFNLVGG--------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V+L + NGLGF+ V +S V IK + PG A+++ + +GD +L V +
Sbjct: 91 VKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 150
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARP 91
G ++V +LR A V LL+ RP
Sbjct: 151 TEGLIFQEVLHLLRGAPQEVTLLLCRP 177
Score = 34.7 bits (76), Expect = 1.0
Identities = 18/42 (42%), Positives = 26/42 (61%), Gaps = 1/42 (2%)
Query: 599 PGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPLP 640
PGDR++ V+GV + T QAVQ LKG P ++ + R +P
Sbjct: 7 PGDRLLQVDGVILCGLTHKQAVQCLKG-PGQVARLVLERRVP 47
Score = 34.3 bits (75), Expect = 1.4
Identities = 15/36 (41%), Positives = 24/36 (66%)
Query: 246 DRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
DR+++VDG+ L ++ Q+V+ L+ G LVLER
Sbjct: 9 DRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLER 44
Score = 33.5 bits (73), Expect = 2.4
Identities = 28/88 (31%), Positives = 40/88 (45%), Gaps = 7/88 (7%)
Query: 199 VDLNKNVYGLGITVAGYVCEKEELSG-----IFVKSIIEGSSAEQSGKIKINDRIIEVDG 253
V L KN GLG + EKE S + +K + G AE++G I D I+ V+G
Sbjct: 91 VKLKKNANGLGFSFVQM--EKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNG 148
Query: 254 ISLADKSNPQSVEILRNTGISVHLVLER 281
S + + +LR V L+L R
Sbjct: 149 RSTEGLIFQEVLHLLRGAPQEVTLLLCR 176
Score = 31.9 bits (69), Expect = 7.4
Identities = 17/43 (39%), Positives = 23/43 (53%)
Query: 54 GDHVLQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVARPADPAT 96
GD +LQV V L G T +Q L+ G V RL++ R +T
Sbjct: 8 GDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRVPRST 50
>BC073954-1|AAH73954.1| 320|Homo sapiens FERM and PDZ domain
containing 2 protein.
Length = 320
Score = 51.6 bits (118), Expect = 9e-06
Identities = 30/90 (33%), Positives = 49/90 (54%), Gaps = 3/90 (3%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPN--GTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVS 610
V L K GLGFS + + + ++ ++ L PG AE+NG I+ GD +++VNG S
Sbjct: 91 VKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 150
Query: 611 IQNATLDQAVQALKGAPRGTVKVGIARPLP 640
+ + + L+GAP+ V + + RP P
Sbjct: 151 TEGLIFQEVLHLLRGAPQ-EVTLLLCRPPP 179
Score = 41.5 bits (93), Expect = 0.009
Identities = 29/87 (33%), Positives = 45/87 (51%), Gaps = 8/87 (9%)
Query: 13 VELTNDGNGLGFNLVGG--------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V+L + NGLGF+ V +S V IK + PG A+++ + +GD +L V +
Sbjct: 91 VKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 150
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARP 91
G ++V +LR A V LL+ RP
Sbjct: 151 TEGLIFQEVLHLLRGAPQEVTLLLCRP 177
Score = 34.7 bits (76), Expect = 1.0
Identities = 18/42 (42%), Positives = 26/42 (61%), Gaps = 1/42 (2%)
Query: 599 PGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPLP 640
PGDR++ V+GV + T QAVQ LKG P ++ + R +P
Sbjct: 7 PGDRLLQVDGVILCGLTHKQAVQCLKG-PGQVARLVLERRVP 47
Score = 34.3 bits (75), Expect = 1.4
Identities = 15/36 (41%), Positives = 24/36 (66%)
Query: 246 DRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
DR+++VDG+ L ++ Q+V+ L+ G LVLER
Sbjct: 9 DRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLER 44
Score = 33.5 bits (73), Expect = 2.4
Identities = 28/88 (31%), Positives = 40/88 (45%), Gaps = 7/88 (7%)
Query: 199 VDLNKNVYGLGITVAGYVCEKEELSG-----IFVKSIIEGSSAEQSGKIKINDRIIEVDG 253
V L KN GLG + EKE S + +K + G AE++G I D I+ V+G
Sbjct: 91 VKLKKNANGLGFSFVQM--EKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNG 148
Query: 254 ISLADKSNPQSVEILRNTGISVHLVLER 281
S + + +LR V L+L R
Sbjct: 149 RSTEGLIFQEVLHLLRGAPQEVTLLLCR 176
Score = 31.9 bits (69), Expect = 7.4
Identities = 17/43 (39%), Positives = 23/43 (53%)
Query: 54 GDHVLQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVARPADPAT 96
GD +LQV V L G T +Q L+ G V RL++ R +T
Sbjct: 8 GDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRVPRST 50
>BC072395-1|AAH72395.1| 320|Homo sapiens FRMPD2 related 1 protein.
Length = 320
Score = 51.6 bits (118), Expect = 9e-06
Identities = 30/90 (33%), Positives = 49/90 (54%), Gaps = 3/90 (3%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPN--GTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVS 610
V L K GLGFS + + + ++ ++ L PG AE+NG I+ GD +++VNG S
Sbjct: 91 VKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 150
Query: 611 IQNATLDQAVQALKGAPRGTVKVGIARPLP 640
+ + + L+GAP+ V + + RP P
Sbjct: 151 TEGLIFQEVLHLLRGAPQ-EVTLLLCRPPP 179
Score = 41.5 bits (93), Expect = 0.009
Identities = 29/87 (33%), Positives = 45/87 (51%), Gaps = 8/87 (9%)
Query: 13 VELTNDGNGLGFNLVGG--------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V+L + NGLGF+ V +S V IK + PG A+++ + +GD +L V +
Sbjct: 91 VKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 150
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARP 91
G ++V +LR A V LL+ RP
Sbjct: 151 TEGLIFQEVLHLLRGAPQEVTLLLCRP 177
Score = 34.7 bits (76), Expect = 1.0
Identities = 18/42 (42%), Positives = 26/42 (61%), Gaps = 1/42 (2%)
Query: 599 PGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPLP 640
PGDR++ V+GV + T QAVQ LKG P ++ + R +P
Sbjct: 7 PGDRLLQVDGVILCGLTHKQAVQCLKG-PGQVARLVLERRVP 47
Score = 34.3 bits (75), Expect = 1.4
Identities = 15/36 (41%), Positives = 24/36 (66%)
Query: 246 DRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
DR+++VDG+ L ++ Q+V+ L+ G LVLER
Sbjct: 9 DRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLER 44
Score = 33.5 bits (73), Expect = 2.4
Identities = 28/88 (31%), Positives = 40/88 (45%), Gaps = 7/88 (7%)
Query: 199 VDLNKNVYGLGITVAGYVCEKEELSG-----IFVKSIIEGSSAEQSGKIKINDRIIEVDG 253
V L KN GLG + EKE S + +K + G AE++G I D I+ V+G
Sbjct: 91 VKLKKNANGLGFSFVQM--EKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNG 148
Query: 254 ISLADKSNPQSVEILRNTGISVHLVLER 281
S + + +LR V L+L R
Sbjct: 149 RSTEGLIFQEVLHLLRGAPQEVTLLLCR 176
Score = 31.9 bits (69), Expect = 7.4
Identities = 17/43 (39%), Positives = 23/43 (53%)
Query: 54 GDHVLQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVARPADPAT 96
GD +LQV V L G T +Q L+ G V RL++ R +T
Sbjct: 8 GDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRVPRST 50
>BC071635-1|AAH71635.1| 320|Homo sapiens FRMPD2 related 2 protein.
Length = 320
Score = 51.6 bits (118), Expect = 9e-06
Identities = 30/90 (33%), Positives = 49/90 (54%), Gaps = 3/90 (3%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPN--GTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVS 610
V L K GLGFS + + + ++ ++ L PG AE+NG I+ GD +++VNG S
Sbjct: 91 VKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 150
Query: 611 IQNATLDQAVQALKGAPRGTVKVGIARPLP 640
+ + + L+GAP+ V + + RP P
Sbjct: 151 TEGLIFQEVLHLLRGAPQ-EVTLLLCRPPP 179
Score = 41.5 bits (93), Expect = 0.009
Identities = 29/87 (33%), Positives = 45/87 (51%), Gaps = 8/87 (9%)
Query: 13 VELTNDGNGLGFNLVGG--------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V+L + NGLGF+ V +S V IK + PG A+++ + +GD +L V +
Sbjct: 91 VKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 150
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARP 91
G ++V +LR A V LL+ RP
Sbjct: 151 TEGLIFQEVLHLLRGAPQEVTLLLCRP 177
Score = 34.7 bits (76), Expect = 1.0
Identities = 18/42 (42%), Positives = 26/42 (61%), Gaps = 1/42 (2%)
Query: 599 PGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIARPLP 640
PGDR++ V+GV + T QAVQ LKG P ++ + R +P
Sbjct: 7 PGDRLLQVDGVILCGLTHKQAVQCLKG-PGQVARLVLERRVP 47
Score = 34.3 bits (75), Expect = 1.4
Identities = 15/36 (41%), Positives = 24/36 (66%)
Query: 246 DRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
DR+++VDG+ L ++ Q+V+ L+ G LVLER
Sbjct: 9 DRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLER 44
Score = 33.5 bits (73), Expect = 2.4
Identities = 28/88 (31%), Positives = 40/88 (45%), Gaps = 7/88 (7%)
Query: 199 VDLNKNVYGLGITVAGYVCEKEELSG-----IFVKSIIEGSSAEQSGKIKINDRIIEVDG 253
V L KN GLG + EKE S + +K + G AE++G I D I+ V+G
Sbjct: 91 VKLKKNANGLGFSFVQM--EKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNG 148
Query: 254 ISLADKSNPQSVEILRNTGISVHLVLER 281
S + + +LR V L+L R
Sbjct: 149 RSTEGLIFQEVLHLLRGAPQEVTLLLCR 176
Score = 31.9 bits (69), Expect = 7.4
Identities = 17/43 (39%), Positives = 23/43 (53%)
Query: 54 GDHVLQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVARPADPAT 96
GD +LQV V L G T +Q L+ G V RL++ R +T
Sbjct: 8 GDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRVPRST 50
>BC063590-1|AAH63590.1| 649|Homo sapiens SCRIB protein protein.
Length = 649
Score = 51.6 bits (118), Expect = 9e-06
Identities = 33/81 (40%), Positives = 40/81 (49%), Gaps = 4/81 (4%)
Query: 393 EGLGISLEGTVDVEGGQELRPHH---YIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGL 449
E LGIS+ G G P +I V P G G G L G LLEVN+ L GL
Sbjct: 104 ERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGL 163
Query: 450 THSEVVNILKQLPDRVR-LVC 469
TH E V +L+ + D + LVC
Sbjct: 164 THGEAVQLLRSVGDTLTVLVC 184
Score = 40.3 bits (90), Expect = 0.021
Identities = 25/78 (32%), Positives = 37/78 (47%), Gaps = 1/78 (1%)
Query: 33 GVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVAAVLRQAGPVVRLLVARPA 92
G+ I V P G A +D RL+ G +L+V +L G T + +LR G + +LV
Sbjct: 128 GIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGF 187
Query: 93 DPAT-ALRAPQPGTALVP 109
+ +T A PG P
Sbjct: 188 EASTDAALEVSPGVIANP 205
Score = 39.5 bits (88), Expect = 0.037
Identities = 24/73 (32%), Positives = 41/73 (56%), Gaps = 5/73 (6%)
Query: 555 LVKADQGLGFSILDYQD----PVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVS 610
L +A LG SI+ D P + + ++P G+A ++G + GDR+++VNG
Sbjct: 2 LPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQD 60
Query: 611 IQNATLDQAVQAL 623
+++AT +AV AL
Sbjct: 61 VRDATHQEAVSAL 73
Score = 35.9 bits (79), Expect = 0.45
Identities = 30/91 (32%), Positives = 44/91 (48%), Gaps = 12/91 (13%)
Query: 15 LTNDGNGLGFNLVGG----------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
L G LG ++VGG + GV I VLP G+A + L+ GD +L V +
Sbjct: 2 LPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQD 60
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVAR-PADP 94
+R T ++ + L + + LLV R PA P
Sbjct: 61 VRDATHQEAVSALLRPCLELSLLVRRDPAPP 91
Score = 35.5 bits (78), Expect = 0.60
Identities = 18/54 (33%), Positives = 29/54 (53%)
Query: 571 DPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALK 624
+P DP I + + P G A ++G + G R++ VN S+ T +AVQ L+
Sbjct: 120 NPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLR 173
Score = 35.1 bits (77), Expect = 0.79
Identities = 14/49 (28%), Positives = 32/49 (65%)
Query: 224 GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTG 272
GIF+ + +A + G++++ R++EV+ SL ++ ++V++LR+ G
Sbjct: 128 GIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVG 176
Score = 34.3 bits (75), Expect = 1.4
Identities = 35/115 (30%), Positives = 47/115 (40%), Gaps = 9/115 (7%)
Query: 395 LGISLEGTVDVE----GGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLT 450
LG+S+ G D G QE P +I VLP G G L GD +L VN + T
Sbjct: 9 LGLSIVGGSDHSSHPFGVQE--PGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDAT 65
Query: 451 HSEVVNILKQLPDRVRLVCARNSIDSGPRP--VVNLASDREGFEARKIISGSLNN 503
H E V+ L + + L+ R+ G R + +R G R G N
Sbjct: 66 HQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGN 120
Score = 34.3 bits (75), Expect = 1.4
Identities = 15/58 (25%), Positives = 34/58 (58%), Gaps = 1/58 (1%)
Query: 224 GIFVKSIIEGSSAEQSGKIKINDRIIEVDGISLADKSNPQSVEILRNTGISVHLVLER 281
G+F+ ++ A +SG +++ DRI+ V+G + D ++ ++V L + + L++ R
Sbjct: 30 GVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRR 86
>BC050362-1|AAH50362.1| 576|Homo sapiens Unknown (protein for
IMAGE:6043943) protein.
Length = 576
Score = 51.6 bits (118), Expect = 9e-06
Identities = 28/81 (34%), Positives = 44/81 (54%), Gaps = 4/81 (4%)
Query: 18 DGNGLGFNLVGG---RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVA 74
+G GLGF+L GG + + + V P G+A ++ +Q G+ VL + +L+G T
Sbjct: 419 EGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDAL 478
Query: 75 AVLRQA-GPVVRLLVARPADP 94
A+LRQA P ++V R P
Sbjct: 479 AILRQAREPRQAVIVTRKLTP 499
Score = 49.2 bits (112), Expect = 5e-05
Identities = 45/165 (27%), Positives = 76/165 (46%), Gaps = 13/165 (7%)
Query: 325 TEIEPEPESNTTIDSSVLEVGD--LQEPTQEELDQRFDEILAVDKEDIVKKWKEEIGSDK 382
TE E + + D S L+ G + + EEL + +E+ +D+ + K+ G
Sbjct: 357 TEGLTEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATL----KQLDGIHV 412
Query: 383 EILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVN 442
IL E + GLG SL G D+E + + H V P+G +G + G+E+L +N
Sbjct: 413 TILHKE--EGAGLGFSLAGGADLEN-KVITVHR----VFPNGLASQEGTIQKGNEVLSIN 465
Query: 443 EYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASD 487
L G TH + + IL+Q + + V + P +N ++D
Sbjct: 466 GKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTD 510
Score = 48.0 bits (109), Expect = 1e-04
Identities = 28/82 (34%), Positives = 41/82 (50%), Gaps = 3/82 (3%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLGFS+ D VI V + P G+A + G I G+ V+S+NG S++ T A+
Sbjct: 422 GLGFSLAG---GADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDAL 478
Query: 621 QALKGAPRGTVKVGIARPLPPQ 642
L+ A V + R L P+
Sbjct: 479 AILRQAREPRQAVIVTRKLTPE 500
>BC031614-1|AAH31614.1| 261|Homo sapiens FERM and PDZ domain
containing 2 protein.
Length = 261
Score = 51.6 bits (118), Expect = 9e-06
Identities = 30/90 (33%), Positives = 49/90 (54%), Gaps = 3/90 (3%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPN--GTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVS 610
V L K GLGFS + + + ++ ++ L PG AE+NG I+ GD +++VNG S
Sbjct: 32 VKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 91
Query: 611 IQNATLDQAVQALKGAPRGTVKVGIARPLP 640
+ + + L+GAP+ V + + RP P
Sbjct: 92 TEGLIFQEVLHLLRGAPQ-EVTLLLCRPPP 120
Score = 41.5 bits (93), Expect = 0.009
Identities = 29/87 (33%), Positives = 45/87 (51%), Gaps = 8/87 (9%)
Query: 13 VELTNDGNGLGFNLVGG--------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V+L + NGLGF+ V +S V IK + PG A+++ + +GD +L V +
Sbjct: 32 VKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 91
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARP 91
G ++V +LR A V LL+ RP
Sbjct: 92 TEGLIFQEVLHLLRGAPQEVTLLLCRP 118
Score = 33.5 bits (73), Expect = 2.4
Identities = 28/88 (31%), Positives = 40/88 (45%), Gaps = 7/88 (7%)
Query: 199 VDLNKNVYGLGITVAGYVCEKEELSG-----IFVKSIIEGSSAEQSGKIKINDRIIEVDG 253
V L KN GLG + EKE S + +K + G AE++G I D I+ V+G
Sbjct: 32 VKLKKNANGLGFSFVQM--EKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNG 89
Query: 254 ISLADKSNPQSVEILRNTGISVHLVLER 281
S + + +LR V L+L R
Sbjct: 90 RSTEGLIFQEVLHLLRGAPQEVTLLLCR 117
>AY497901-1|AAR89904.1| 631|Homo sapiens interleukin 16 (lymphocyte
chemoattractant factor) protein.
Length = 631
Score = 51.6 bits (118), Expect = 9e-06
Identities = 28/81 (34%), Positives = 44/81 (54%), Gaps = 4/81 (4%)
Query: 18 DGNGLGFNLVGG---RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVA 74
+G GLGF+L GG + + + V P G+A ++ +Q G+ VL + +L+G T
Sbjct: 419 EGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDAL 478
Query: 75 AVLRQA-GPVVRLLVARPADP 94
A+LRQA P ++V R P
Sbjct: 479 AILRQAREPRQAVIVTRKLTP 499
Score = 49.2 bits (112), Expect = 5e-05
Identities = 45/165 (27%), Positives = 76/165 (46%), Gaps = 13/165 (7%)
Query: 325 TEIEPEPESNTTIDSSVLEVGD--LQEPTQEELDQRFDEILAVDKEDIVKKWKEEIGSDK 382
TE E + + D S L+ G + + EEL + +E+ +D+ + K+ G
Sbjct: 357 TEGLTEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATL----KQLDGIHV 412
Query: 383 EILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVN 442
IL E + GLG SL G D+E + + H V P+G +G + G+E+L +N
Sbjct: 413 TILHKE--EGAGLGFSLAGGADLEN-KVITVHR----VFPNGLASQEGTIQKGNEVLSIN 465
Query: 443 EYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASD 487
L G TH + + IL+Q + + V + P +N ++D
Sbjct: 466 GKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTD 510
Score = 48.0 bits (109), Expect = 1e-04
Identities = 28/82 (34%), Positives = 41/82 (50%), Gaps = 3/82 (3%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLGFS+ D VI V + P G+A + G I G+ V+S+NG S++ T A+
Sbjct: 422 GLGFSLAG---GADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDAL 478
Query: 621 QALKGAPRGTVKVGIARPLPPQ 642
L+ A V + R L P+
Sbjct: 479 AILRQAREPRQAVIVTRKLTPE 500
Score = 43.6 bits (98), Expect = 0.002
Identities = 24/85 (28%), Positives = 43/85 (50%), Gaps = 1/85 (1%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
V L K GLGFS+ + + + + + R + G +E++ + PGD ++ + G ++Q
Sbjct: 534 VTLEKMSAGLGFSLEGGKGSLHGDKPLTINR-IFKGAASEQSETVQPGDEILQLGGTAMQ 592
Query: 613 NATLDQAVQALKGAPRGTVKVGIAR 637
T +A +K P G V + I R
Sbjct: 593 GLTRFEAWNIIKALPDGPVTIVIRR 617
Score = 41.5 bits (93), Expect = 0.009
Identities = 27/89 (30%), Positives = 44/89 (49%), Gaps = 7/89 (7%)
Query: 2 VLSTEWAQVEVVELTNDGNGLGFNLVGGRST-----GVVIKYVLPGGVADKDRRLQSGDH 56
V ST A V V L GLGF+L GG+ + + I + G +++ +Q GD
Sbjct: 523 VESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDE 582
Query: 57 VLQVGSVNLRGFTSEQVAAVLRQA--GPV 83
+LQ+G ++G T + +++ GPV
Sbjct: 583 ILQLGGTAMQGLTRFEAWNIIKALPDGPV 611
Score = 40.7 bits (91), Expect = 0.016
Identities = 31/103 (30%), Positives = 50/103 (48%), Gaps = 7/103 (6%)
Query: 377 EIGSDKEILVAEIKKLE-GLGISLEGTV-DVEGGQELRPHHYIRSVLPDGPVGLQGVLNA 434
E ++ + ++K+ GLG SLEG + G + L + + + +Q
Sbjct: 524 ESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQ----P 579
Query: 435 GDELLEVNEYRLHGLTHSEVVNILKQLPD-RVRLVCARNSIDS 476
GDE+L++ + GLT E NI+K LPD V +V R S+ S
Sbjct: 580 GDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQS 622
>AY491519-1|AAS79660.1| 261|Homo sapiens PDZ domain-containing
protein 4 protein.
Length = 261
Score = 51.6 bits (118), Expect = 9e-06
Identities = 30/90 (33%), Positives = 49/90 (54%), Gaps = 3/90 (3%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPN--GTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVS 610
V L K GLGFS + + + ++ ++ L PG AE+NG I+ GD +++VNG S
Sbjct: 32 VKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 91
Query: 611 IQNATLDQAVQALKGAPRGTVKVGIARPLP 640
+ + + L+GAP+ V + + RP P
Sbjct: 92 TEGLIFQEVLHLLRGAPQ-EVTLLLCRPPP 120
Score = 41.5 bits (93), Expect = 0.009
Identities = 29/87 (33%), Positives = 45/87 (51%), Gaps = 8/87 (9%)
Query: 13 VELTNDGNGLGFNLVGG--------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V+L + NGLGF+ V +S V IK + PG A+++ + +GD +L V +
Sbjct: 32 VKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 91
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARP 91
G ++V +LR A V LL+ RP
Sbjct: 92 TEGLIFQEVLHLLRGAPQEVTLLLCRP 118
Score = 33.5 bits (73), Expect = 2.4
Identities = 28/88 (31%), Positives = 40/88 (45%), Gaps = 7/88 (7%)
Query: 199 VDLNKNVYGLGITVAGYVCEKEELSG-----IFVKSIIEGSSAEQSGKIKINDRIIEVDG 253
V L KN GLG + EKE S + +K + G AE++G I D I+ V+G
Sbjct: 32 VKLKKNANGLGFSFVQM--EKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNG 89
Query: 254 ISLADKSNPQSVEILRNTGISVHLVLER 281
S + + +LR V L+L R
Sbjct: 90 RSTEGLIFQEVLHLLRGAPQEVTLLLCR 117
>AL450334-6|CAI15688.1| 223|Homo sapiens PDZ domain containing 5B
protein.
Length = 223
Score = 51.6 bits (118), Expect = 9e-06
Identities = 30/90 (33%), Positives = 49/90 (54%), Gaps = 3/90 (3%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPN--GTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVS 610
V L K GLGFS + + + ++ ++ L PG AE+NG I+ GD +++VNG S
Sbjct: 32 VKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 91
Query: 611 IQNATLDQAVQALKGAPRGTVKVGIARPLP 640
+ + + L+GAP+ V + + RP P
Sbjct: 92 TEGLIFQEVLHLLRGAPQ-EVTLLLCRPPP 120
Score = 41.5 bits (93), Expect = 0.009
Identities = 29/87 (33%), Positives = 45/87 (51%), Gaps = 8/87 (9%)
Query: 13 VELTNDGNGLGFNLVGG--------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V+L + NGLGF+ V +S V IK + PG A+++ + +GD +L V +
Sbjct: 32 VKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 91
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARP 91
G ++V +LR A V LL+ RP
Sbjct: 92 TEGLIFQEVLHLLRGAPQEVTLLLCRP 118
Score = 33.5 bits (73), Expect = 2.4
Identities = 28/88 (31%), Positives = 40/88 (45%), Gaps = 7/88 (7%)
Query: 199 VDLNKNVYGLGITVAGYVCEKEELSG-----IFVKSIIEGSSAEQSGKIKINDRIIEVDG 253
V L KN GLG + EKE S + +K + G AE++G I D I+ V+G
Sbjct: 32 VKLKKNANGLGFSFVQM--EKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNG 89
Query: 254 ISLADKSNPQSVEILRNTGISVHLVLER 281
S + + +LR V L+L R
Sbjct: 90 RSTEGLIFQEVLHLLRGAPQEVTLLLCR 117
>AL450334-5|CAI15687.1| 261|Homo sapiens PDZ domain containing 5B
protein.
Length = 261
Score = 51.6 bits (118), Expect = 9e-06
Identities = 30/90 (33%), Positives = 49/90 (54%), Gaps = 3/90 (3%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPN--GTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVS 610
V L K GLGFS + + + ++ ++ L PG AE+NG I+ GD +++VNG S
Sbjct: 32 VKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 91
Query: 611 IQNATLDQAVQALKGAPRGTVKVGIARPLP 640
+ + + L+GAP+ V + + RP P
Sbjct: 92 TEGLIFQEVLHLLRGAPQ-EVTLLLCRPPP 120
Score = 41.5 bits (93), Expect = 0.009
Identities = 29/87 (33%), Positives = 45/87 (51%), Gaps = 8/87 (9%)
Query: 13 VELTNDGNGLGFNLVGG--------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVN 64
V+L + NGLGF+ V +S V IK + PG A+++ + +GD +L V +
Sbjct: 32 VKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 91
Query: 65 LRGFTSEQVAAVLRQAGPVVRLLVARP 91
G ++V +LR A V LL+ RP
Sbjct: 92 TEGLIFQEVLHLLRGAPQEVTLLLCRP 118
Score = 33.5 bits (73), Expect = 2.4
Identities = 28/88 (31%), Positives = 40/88 (45%), Gaps = 7/88 (7%)
Query: 199 VDLNKNVYGLGITVAGYVCEKEELSG-----IFVKSIIEGSSAEQSGKIKINDRIIEVDG 253
V L KN GLG + EKE S + +K + G AE++G I D I+ V+G
Sbjct: 32 VKLKKNANGLGFSFVQM--EKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNG 89
Query: 254 ISLADKSNPQSVEILRNTGISVHLVLER 281
S + + +LR V L+L R
Sbjct: 90 RSTEGLIFQEVLHLLRGAPQEVTLLLCR 117
>AK222512-1|BAD96232.1| 677|Homo sapiens Hypothetical protein
FLJ42574 variant protein.
Length = 677
Score = 51.6 bits (118), Expect = 9e-06
Identities = 28/81 (34%), Positives = 44/81 (54%), Gaps = 4/81 (4%)
Query: 18 DGNGLGFNLVGG---RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVA 74
+G GLGF+L GG + + + V P G+A ++ +Q G+ VL + +L+G T
Sbjct: 466 EGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDAL 525
Query: 75 AVLRQA-GPVVRLLVARPADP 94
A+LRQA P ++V R P
Sbjct: 526 AILRQAREPRQAVIVTRKLTP 546
Score = 48.0 bits (109), Expect = 1e-04
Identities = 28/82 (34%), Positives = 41/82 (50%), Gaps = 3/82 (3%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLGFS+ D VI V + P G+A + G I G+ V+S+NG S++ T A+
Sbjct: 469 GLGFSLAG---GADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDAL 525
Query: 621 QALKGAPRGTVKVGIARPLPPQ 642
L+ A V + R L P+
Sbjct: 526 AILRQAREPRQAVIVTRKLTPE 547
Score = 47.6 bits (108), Expect = 1e-04
Identities = 45/165 (27%), Positives = 75/165 (45%), Gaps = 13/165 (7%)
Query: 325 TEIEPEPESNTTIDSSVLEVGD--LQEPTQEELDQRFDEILAVDKEDIVKKWKEEIGSDK 382
TE E + + D S L+ G + + EEL + +E +D+ + K+ G
Sbjct: 404 TEGLTEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEAKVLDEATL----KQLDGIHV 459
Query: 383 EILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVN 442
IL E + GLG SL G D+E + + H V P+G +G + G+E+L +N
Sbjct: 460 TILHKE--EGAGLGFSLAGGADLEN-KVITVHR----VFPNGLASQEGTIQKGNEVLSIN 512
Query: 443 EYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASD 487
L G TH + + IL+Q + + V + P +N ++D
Sbjct: 513 GKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTD 557
Score = 44.4 bits (100), Expect = 0.001
Identities = 29/112 (25%), Positives = 51/112 (45%), Gaps = 1/112 (0%)
Query: 526 NHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSL 585
N S S S S + ++ V L K GLGFS+ + + + + + R +
Sbjct: 553 NSSTDSAASASAASDVSVESTEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINR-I 611
Query: 586 VPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIAR 637
G +E++ + PGD ++ + G ++Q T +A +K P G V + I R
Sbjct: 612 FKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRR 663
Score = 40.7 bits (91), Expect = 0.016
Identities = 28/89 (31%), Positives = 45/89 (50%), Gaps = 8/89 (8%)
Query: 2 VLSTEWAQVEVVELTNDGNGLGFNLVGGRST-----GVVIKYVLPGGVADKDRRLQSGDH 56
V STE A V V L GLGF+L GG+ + + I + G +++ +Q GD
Sbjct: 570 VESTE-ATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDE 628
Query: 57 VLQVGSVNLRGFTSEQVAAVLRQA--GPV 83
+LQ+G ++G T + +++ GPV
Sbjct: 629 ILQLGGTAMQGLTRFEAWNIIKALPDGPV 657
Score = 40.3 bits (90), Expect = 0.021
Identities = 30/89 (33%), Positives = 43/89 (48%), Gaps = 6/89 (6%)
Query: 390 KKLEGLGISLEGTV-DVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHG 448
K GLG SLEG + G + L + + + +Q GDE+L++ + G
Sbjct: 584 KMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQ----PGDEILQLGGTAMQG 639
Query: 449 LTHSEVVNILKQLPD-RVRLVCARNSIDS 476
LT E NI+K LPD V +V R S+ S
Sbjct: 640 LTRFEAWNIIKALPDGPVTIVIRRKSLQS 668
>AK126222-1|BAC86494.1| 824|Homo sapiens protein ( Homo sapiens
cDNA FLJ44234 fis, clone THYMU3007137, highly similar
to Interleukin-16 precursor. ).
Length = 824
Score = 51.6 bits (118), Expect = 9e-06
Identities = 28/81 (34%), Positives = 44/81 (54%), Gaps = 4/81 (4%)
Query: 18 DGNGLGFNLVGG---RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVA 74
+G GLGF+L GG + + + V P G+A ++ +Q G+ VL + +L+G T
Sbjct: 613 EGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGAIQKGNEVLSINGKSLKGTTHHDAL 672
Query: 75 AVLRQA-GPVVRLLVARPADP 94
A+LRQA P ++V R P
Sbjct: 673 AILRQAREPRQAVIVTRKLTP 693
Score = 49.2 bits (112), Expect = 5e-05
Identities = 45/165 (27%), Positives = 76/165 (46%), Gaps = 13/165 (7%)
Query: 325 TEIEPEPESNTTIDSSVLEVGD--LQEPTQEELDQRFDEILAVDKEDIVKKWKEEIGSDK 382
TE E + + D S L+ G + + EEL + +E+ +D+ + K+ G
Sbjct: 551 TEGLTEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATL----KQLDGIHV 606
Query: 383 EILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVN 442
IL E + GLG SL G D+E + + H V P+G +G + G+E+L +N
Sbjct: 607 TILHKE--EGAGLGFSLAGGADLEN-KVITVHR----VFPNGLASQEGAIQKGNEVLSIN 659
Query: 443 EYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASD 487
L G TH + + IL+Q + + V + P +N ++D
Sbjct: 660 GKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTD 704
Score = 48.0 bits (109), Expect = 1e-04
Identities = 28/82 (34%), Positives = 41/82 (50%), Gaps = 3/82 (3%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLGFS+ D VI V + P G+A + G I G+ V+S+NG S++ T A+
Sbjct: 616 GLGFSLAG---GADLENKVITVHRVFPNGLASQEGAIQKGNEVLSINGKSLKGTTHHDAL 672
Query: 621 QALKGAPRGTVKVGIARPLPPQ 642
L+ A V + R L P+
Sbjct: 673 AILRQAREPRQAVIVTRKLTPE 694
Score = 44.4 bits (100), Expect = 0.001
Identities = 29/112 (25%), Positives = 51/112 (45%), Gaps = 1/112 (0%)
Query: 526 NHSEQSKKSRSLECVSGLAMWQSKEDIVMLVKADQGLGFSILDYQDPVDPNGTVIVVRSL 585
N S S S S + ++ V L K GLGFS+ + + + + + R +
Sbjct: 700 NSSTDSAASASAASDVSVESTEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINR-I 758
Query: 586 VPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAVQALKGAPRGTVKVGIAR 637
G +E++ + PGD ++ + G ++Q T +A +K P G V + I R
Sbjct: 759 FKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRR 810
Score = 40.7 bits (91), Expect = 0.016
Identities = 28/89 (31%), Positives = 45/89 (50%), Gaps = 8/89 (8%)
Query: 2 VLSTEWAQVEVVELTNDGNGLGFNLVGGRST-----GVVIKYVLPGGVADKDRRLQSGDH 56
V STE A V V L GLGF+L GG+ + + I + G +++ +Q GD
Sbjct: 717 VESTE-ATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDE 775
Query: 57 VLQVGSVNLRGFTSEQVAAVLRQA--GPV 83
+LQ+G ++G T + +++ GPV
Sbjct: 776 ILQLGGTAMQGLTRFEAWNIIKALPDGPV 804
Score = 40.3 bits (90), Expect = 0.021
Identities = 30/89 (33%), Positives = 43/89 (48%), Gaps = 6/89 (6%)
Query: 390 KKLEGLGISLEGTV-DVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHG 448
K GLG SLEG + G + L + + + +Q GDE+L++ + G
Sbjct: 731 KMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQ----PGDEILQLGGTAMQG 786
Query: 449 LTHSEVVNILKQLPD-RVRLVCARNSIDS 476
LT E NI+K LPD V +V R S+ S
Sbjct: 787 LTRFEAWNIIKALPDGPVTIVIRRKSLQS 815
>AF077011-1|AAD15990.1| 631|Homo sapiens interleukin 16 protein.
Length = 631
Score = 51.6 bits (118), Expect = 9e-06
Identities = 28/81 (34%), Positives = 44/81 (54%), Gaps = 4/81 (4%)
Query: 18 DGNGLGFNLVGG---RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSVNLRGFTSEQVA 74
+G GLGF+L GG + + + V P G+A ++ +Q G+ VL + +L+G T
Sbjct: 419 EGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDAL 478
Query: 75 AVLRQA-GPVVRLLVARPADP 94
A+LRQA P ++V R P
Sbjct: 479 AILRQAREPRQAVIVTRKLTP 499
Score = 49.2 bits (112), Expect = 5e-05
Identities = 45/165 (27%), Positives = 76/165 (46%), Gaps = 13/165 (7%)
Query: 325 TEIEPEPESNTTIDSSVLEVGD--LQEPTQEELDQRFDEILAVDKEDIVKKWKEEIGSDK 382
TE E + + D S L+ G + + EEL + +E+ +D+ + K+ G
Sbjct: 357 TEGLTEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATL----KQLDGIHV 412
Query: 383 EILVAEIKKLEGLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVN 442
IL E + GLG SL G D+E + + H V P+G +G + G+E+L +N
Sbjct: 413 TILHKE--EGAGLGFSLAGGADLEN-KVITVHR----VFPNGLASQEGTIQKGNEVLSIN 465
Query: 443 EYRLHGLTHSEVVNILKQLPDRVRLVCARNSIDSGPRPVVNLASD 487
L G TH + + IL+Q + + V + P +N ++D
Sbjct: 466 GKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTD 510
Score = 48.0 bits (109), Expect = 1e-04
Identities = 28/82 (34%), Positives = 41/82 (50%), Gaps = 3/82 (3%)
Query: 561 GLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQNATLDQAV 620
GLGFS+ D VI V + P G+A + G I G+ V+S+NG S++ T A+
Sbjct: 422 GLGFSLAG---GADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDAL 478
Query: 621 QALKGAPRGTVKVGIARPLPPQ 642
L+ A V + R L P+
Sbjct: 479 AILRQAREPRQAVIVTRKLTPE 500
Score = 43.6 bits (98), Expect = 0.002
Identities = 24/85 (28%), Positives = 43/85 (50%), Gaps = 1/85 (1%)
Query: 553 VMLVKADQGLGFSILDYQDPVDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNGVSIQ 612
V L K GLGFS+ + + + + + R + G +E++ + PGD ++ + G ++Q
Sbjct: 534 VTLEKMSAGLGFSLEGGKGSLHGDKPLTINR-IFKGAASEQSETVQPGDEILQLGGTAMQ 592
Query: 613 NATLDQAVQALKGAPRGTVKVGIAR 637
T +A +K P G V + I R
Sbjct: 593 GLTRFEAWNIIKALPDGPVTIVIRR 617
Score = 41.5 bits (93), Expect = 0.009
Identities = 27/89 (30%), Positives = 44/89 (49%), Gaps = 7/89 (7%)
Query: 2 VLSTEWAQVEVVELTNDGNGLGFNLVGGRST-----GVVIKYVLPGGVADKDRRLQSGDH 56
V ST A V V L GLGF+L GG+ + + I + G +++ +Q GD
Sbjct: 523 VESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDE 582
Query: 57 VLQVGSVNLRGFTSEQVAAVLRQA--GPV 83
+LQ+G ++G T + +++ GPV
Sbjct: 583 ILQLGGTAMQGLTRFEAWNIIKALPDGPV 611
Score = 40.7 bits (91), Expect = 0.016
Identities = 31/103 (30%), Positives = 50/103 (48%), Gaps = 7/103 (6%)
Query: 377 EIGSDKEILVAEIKKLE-GLGISLEGTV-DVEGGQELRPHHYIRSVLPDGPVGLQGVLNA 434
E ++ + ++K+ GLG SLEG + G + L + + + +Q
Sbjct: 524 ESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQ----P 579
Query: 435 GDELLEVNEYRLHGLTHSEVVNILKQLPD-RVRLVCARNSIDS 476
GDE+L++ + GLT E NI+K LPD V +V R S+ S
Sbjct: 580 GDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQS 622
>BC007704-1|AAH07704.1| 145|Homo sapiens synaptojanin 2 binding
protein protein.
Length = 145
Score = 51.2 bits (117), Expect = 1e-05
Identities = 29/85 (34%), Positives = 41/85 (48%), Gaps = 7/85 (8%)
Query: 11 EVVELTNDGNGLGFNLVGG-------RSTGVVIKYVLPGGVADKDRRLQSGDHVLQVGSV 63
E + LT +GLGFN+VGG +G+ + + G A D RLQ GD +L V
Sbjct: 12 EEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQ 71
Query: 64 NLRGFTSEQVAAVLRQAGPVVRLLV 88
+L+ + + R AG V L V
Sbjct: 72 DLKNLLHQDAVDLFRNAGYAVSLRV 96
Score = 46.4 bits (105), Expect = 3e-04
Identities = 25/88 (28%), Positives = 48/88 (54%), Gaps = 2/88 (2%)
Query: 199 VDLNKNVYGLGITVAGYVCEK--EELSGIFVKSIIEGSSAEQSGKIKINDRIIEVDGISL 256
++L + GLG + G ++ SGI+V I E +A G+++ D+I+ V+G L
Sbjct: 14 INLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDL 73
Query: 257 ADKSNPQSVEILRNTGISVHLVLERYLR 284
+ + +V++ RN G +V L ++ L+
Sbjct: 74 KNLLHQDAVDLFRNAGYAVSLRVQHRLQ 101
Score = 43.6 bits (98), Expect = 0.002
Identities = 24/78 (30%), Positives = 39/78 (50%), Gaps = 1/78 (1%)
Query: 550 EDIVMLVKADQGLGFSILDYQDP-VDPNGTVIVVRSLVPGGVAEKNGEISPGDRVMSVNG 608
E+ + L + GLGF+I+ D N + I V + G A +G + GD+++SVNG
Sbjct: 11 EEEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNG 70
Query: 609 VSIQNATLDQAVQALKGA 626
++N AV + A
Sbjct: 71 QDLKNLLHQDAVDLFRNA 88
Score = 37.1 bits (82), Expect = 0.20
Identities = 25/86 (29%), Positives = 39/86 (45%), Gaps = 2/86 (2%)
Query: 394 GLGISLEGTVDVEGGQELRPHHYIRSVLPDGPVGLQGVLNAGDELLEVNEYRLHGLTHSE 453
GLG ++ G D + Y+ + +G L G L GD++L VN L L H +
Sbjct: 22 GLGFNIVGGTDQQYVSN-DSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDLKNLLHQD 80
Query: 454 VVNILKQLPDRVRL-VCARNSIDSGP 478
V++ + V L V R + +GP
Sbjct: 81 AVDLFRNAGYAVSLRVQHRLQVQNGP 106
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.313 0.133 0.373
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 94,054,358
Number of Sequences: 224733
Number of extensions: 4061418
Number of successful extensions: 13444
Number of sequences better than 10.0: 500
Number of HSP's better than 10.0 without gapping: 545
Number of HSP's successfully gapped in prelim test: 156
Number of HSP's that attempted gapping in prelim test: 8490
Number of HSP's gapped (non-prelim): 4529
length of query: 657
length of database: 73,234,838
effective HSP length: 95
effective length of query: 562
effective length of database: 51,885,203
effective search space: 29159484086
effective search space used: 29159484086
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 42 (21.9 bits)
S2: 68 (31.5 bits)
- SilkBase 1999-2023 -