Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA000770-TA|BGIBMGA000770-PA|IPR002889|Carbohydrate-
binding WSC, IPR003961|Fibronectin, type III, IPR001245|Tyrosine
protein kinase, IPR011009|Protein kinase-like, IPR008957|Fibronectin,
type III-like fold, IPR000719|Protein kinase, IPR000834|Peptidase M14,
carboxypeptidase A, IPR013994|Carbohydrate-binding WSC, subgroup,
IPR002290|Serine/threonine protein kinase
(728 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_UPI0000D560EA Cluster: PREDICTED: similar to CG31127-PA... 484 e-135
UniRef50_P83097 Cluster: Putative tyrosine-protein kinase Wsck p... 292 2e-77
UniRef50_Q7QIM9 Cluster: ENSANGP00000021621; n=3; Culicidae|Rep:... 274 5e-72
UniRef50_UPI0000DB6D34 Cluster: PREDICTED: similar to Wsck CG311... 198 6e-49
UniRef50_Q4RJ67 Cluster: Chromosome 1 SCAF15039, whole genome sh... 149 2e-34
UniRef50_A7RNB1 Cluster: Predicted protein; n=1; Nematostella ve... 148 5e-34
UniRef50_UPI00015B4CAE Cluster: PREDICTED: similar to ENSANGP000... 146 2e-33
UniRef50_Q02763 Cluster: Angiopoietin-1 receptor precursor; n=41... 144 7e-33
UniRef50_P79950 Cluster: Tyrosine kinase receptor; n=3; Xenopus|... 143 1e-32
UniRef50_Q7PYY7 Cluster: ENSANGP00000019144; n=1; Anopheles gamb... 143 1e-32
UniRef50_Q9VBW3 Cluster: Tyrosine kinase receptor Cad96Ca precur... 143 1e-32
UniRef50_UPI0000DB7F8D Cluster: PREDICTED: similar to Cad96Ca CG... 143 2e-32
UniRef50_Q64GK4 Cluster: C-Met receptor tyrosine kinase; n=9; Cl... 141 5e-32
UniRef50_P23049 Cluster: Tyrosine-protein kinase transforming pr... 141 5e-32
UniRef50_P11362 Cluster: Basic fibroblast growth factor receptor... 141 5e-32
UniRef50_Q3TJ05 Cluster: 14 days pregnant adult female placenta ... 140 9e-32
UniRef50_P17948 Cluster: Vascular endothelial growth factor rece... 140 2e-31
UniRef50_Q4SII9 Cluster: Chromosome 5 SCAF14581, whole genome sh... 139 3e-31
UniRef50_A7RGV3 Cluster: Predicted protein; n=1; Nematostella ve... 139 3e-31
UniRef50_A3EXK6 Cluster: Fibroblast growth factor receptor c; n=... 139 3e-31
UniRef50_Q04912 Cluster: Macrophage-stimulating protein receptor... 139 3e-31
UniRef50_Q8MY85 Cluster: Fibroblast growth factor receptor 2 pre... 139 3e-31
UniRef50_P35590 Cluster: Tyrosine-protein kinase receptor Tie-1 ... 138 4e-31
UniRef50_UPI0000D577C3 Cluster: PREDICTED: similar to CG8874-PB,... 138 5e-31
UniRef50_Q4SR43 Cluster: Chromosome 11 SCAF14528, whole genome s... 138 5e-31
UniRef50_Q6DTW4 Cluster: Tyrosine kinase receptor ron; n=6; Eume... 138 5e-31
UniRef50_UPI0000E49FB6 Cluster: PREDICTED: similar to RE05926p, ... 138 6e-31
UniRef50_O76978 Cluster: Tyrosine kinase; n=1; Sycon raphanus|Re... 138 6e-31
UniRef50_P22182 Cluster: Fibroblast growth factor receptor 1 pre... 138 6e-31
UniRef50_Q9YGM5 Cluster: Plasminogen related growth factor recep... 137 9e-31
UniRef50_Q8IXC7 Cluster: Isoform of FGFR2; n=23; Euteleostomi|Re... 137 9e-31
UniRef50_A7RHT9 Cluster: Predicted protein; n=1; Nematostella ve... 137 1e-30
UniRef50_A3EXK5 Cluster: Fibroblast growth factor receptor b; n=... 137 1e-30
UniRef50_A3EXK4 Cluster: Fibroblast growth factor receptor a; n=... 137 1e-30
UniRef50_P08581 Cluster: Hepatocyte growth factor receptor precu... 136 1e-30
UniRef50_UPI0000D55449 Cluster: PREDICTED: similar to CG7223-PA,... 136 2e-30
UniRef50_Q179Z3 Cluster: Tyrosine-protein kinase; n=1; Aedes aeg... 136 2e-30
UniRef50_A7RZ71 Cluster: Predicted protein; n=1; Nematostella ve... 136 3e-30
UniRef50_Q0PDJ5 Cluster: Protein tyrosine kinase CSK; n=1; Monos... 135 3e-30
UniRef50_P16591 Cluster: Proto-oncogene tyrosine-protein kinase ... 135 5e-30
UniRef50_Q4RXB0 Cluster: Chromosome 11 SCAF14979, whole genome s... 134 6e-30
UniRef50_Q17J18 Cluster: Tyrosine-protein kinase; n=4; Endoptery... 134 6e-30
UniRef50_Q59F30 Cluster: Fibroblast growth factor receptor 4 var... 134 6e-30
UniRef50_Q86PM4 Cluster: Fibroblast growth factor receptor precu... 134 6e-30
UniRef50_Q8JG38 Cluster: Fibroblast growth factor receptor 2 pre... 134 6e-30
UniRef50_A7SL46 Cluster: Predicted protein; n=2; Eumetazoa|Rep: ... 134 1e-29
UniRef50_P13368 Cluster: Protein sevenless; n=20; Eumetazoa|Rep:... 134 1e-29
UniRef50_P08069 Cluster: Insulin-like growth factor 1 receptor p... 132 2e-29
UniRef50_Q9Y1Z0 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 132 3e-29
UniRef50_Q09147 Cluster: Fibroblast growth factor receptor homol... 132 3e-29
UniRef50_Q4S1S8 Cluster: Chromosome undetermined SCAF14764, whol... 132 4e-29
UniRef50_Q1JUB8 Cluster: Fibroblast growth factor receptor; n=2;... 132 4e-29
UniRef50_A7RGW8 Cluster: Predicted protein; n=1; Nematostella ve... 132 4e-29
UniRef50_Q7YZW6 Cluster: Putative uncharacterized protein; n=3; ... 131 6e-29
UniRef50_P08630 Cluster: Tyrosine-protein kinase Btk29A; n=10; E... 131 7e-29
UniRef50_UPI0000F1FB23 Cluster: PREDICTED: similar to tyrosine p... 130 1e-28
UniRef50_UPI000065F6B2 Cluster: Receptor tyrosine-protein kinase... 130 1e-28
UniRef50_Q9BLY1 Cluster: Receptor tyrosine kinase; n=5; Caenorha... 130 1e-28
UniRef50_Q8INU0 Cluster: CG14396-PD, isoform D; n=10; Sophophora... 130 1e-28
UniRef50_Q674V1 Cluster: Vascular endothelial growth factor rece... 130 1e-28
UniRef50_Q8AXB3 Cluster: Vascular endothelial growth factor rece... 130 1e-28
UniRef50_Q08881 Cluster: Tyrosine-protein kinase ITK/TSK; n=18; ... 130 1e-28
UniRef50_Q7PWP1 Cluster: ENSANGP00000013218; n=2; Culicidae|Rep:... 130 1e-28
UniRef50_Q03142 Cluster: Fibroblast growth factor receptor 4 pre... 130 1e-28
UniRef50_Q4S351 Cluster: Chromosome 4 SCAF14752, whole genome sh... 130 2e-28
UniRef50_Q8WRF4 Cluster: Receptor tyrosine kinase; n=1; Monosiga... 130 2e-28
UniRef50_Q7YT64 Cluster: Tyrosine-protein kinase receptor; n=1; ... 130 2e-28
UniRef50_P42680 Cluster: Tyrosine-protein kinase Tec; n=86; Coel... 130 2e-28
UniRef50_P42685 Cluster: Tyrosine-protein kinase FRK; n=27; Fung... 130 2e-28
UniRef50_P18106 Cluster: Tyrosine-protein kinase Fps85D; n=12; E... 130 2e-28
UniRef50_Q9Y1Y5 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 129 2e-28
UniRef50_Q4H3B8 Cluster: Tyrosine-protein kinase receptor; n=1; ... 129 2e-28
UniRef50_P42679 Cluster: Megakaryocyte-associated tyrosine-prote... 129 2e-28
UniRef50_Q9Y1Y1 Cluster: Protein tyrosine kinase; n=2; cellular ... 129 3e-28
UniRef50_Q8MY86 Cluster: Fibroblast growth factor receptor 1 pre... 129 3e-28
UniRef50_Q06187 Cluster: Tyrosine-protein kinase BTK; n=54; Gnat... 129 3e-28
UniRef50_Q2VXS7 Cluster: Proto-oncogene c-fes variant 4; n=77; E... 128 4e-28
UniRef50_O73798 Cluster: Insulin-like growth factor 1 receptor p... 128 4e-28
UniRef50_Q4H2M8 Cluster: Tyrosine-protein kinase receptor; n=1; ... 128 5e-28
UniRef50_P07949 Cluster: Proto-oncogene tyrosine-protein kinase ... 128 5e-28
UniRef50_Q95YM9 Cluster: Fibroblast growth factor receptor precu... 128 5e-28
UniRef50_Q9U8U8 Cluster: VEGFR-like; n=1; Branchiostoma belcheri... 128 7e-28
UniRef50_P00522 Cluster: Tyrosine-protein kinase Abl; n=5; Eumet... 128 7e-28
UniRef50_Q7YSY1 Cluster: Fes-like tyrosine kinase protein; n=1; ... 127 9e-28
UniRef50_Q6NP28 Cluster: LP09923p; n=6; Endopterygota|Rep: LP099... 127 9e-28
UniRef50_P00533 Cluster: Epidermal growth factor receptor precur... 127 9e-28
UniRef50_Q7QAK4 Cluster: ENSANGP00000020257; n=1; Anopheles gamb... 127 1e-27
UniRef50_Q8NFA8 Cluster: Transmembrane receptor PTK7-2; n=18; Eu... 127 1e-27
UniRef50_Q13308 Cluster: Tyrosine-protein kinase-like 7 precurso... 127 1e-27
UniRef50_Q07407 Cluster: Fibroblast growth factor receptor homol... 127 1e-27
UniRef50_Q8IQ00 Cluster: CG3277-PB, isoform B; n=3; Sophophora|R... 126 2e-27
UniRef50_P35968 Cluster: Vascular endothelial growth factor rece... 126 2e-27
UniRef50_Q12866 Cluster: Proto-oncogene tyrosine-protein kinase ... 126 2e-27
UniRef50_Q4SJQ3 Cluster: Tyrosine-protein kinase receptor; n=1; ... 126 2e-27
UniRef50_Q170Z1 Cluster: Tyrosine-protein kinase receptor; n=1; ... 126 2e-27
UniRef50_Q26614 Cluster: Fibroblast growth factor receptor precu... 126 2e-27
UniRef50_Q9XYS4 Cluster: Tyrosine kinase receptor HTK32; n=1; Hy... 126 3e-27
UniRef50_Q9U5A8 Cluster: Insulin receptor-like protein precursor... 126 3e-27
UniRef50_O97191 Cluster: Tyrosine-protein kinase receptor; n=1; ... 126 3e-27
UniRef50_Q25177 Cluster: Receptor protein-tyrosine kinase; n=2; ... 125 4e-27
UniRef50_Q70DV1 Cluster: Src tyrosine kinase; n=1; Schistosoma m... 125 5e-27
UniRef50_P00534 Cluster: Tyrosine-protein kinase transforming pr... 125 5e-27
UniRef50_Q5TUS8 Cluster: Tyrosine-protein kinase receptor; n=1; ... 124 6e-27
UniRef50_Q5K4G5 Cluster: Receptor tyrosine kinase; n=1; Suberite... 124 6e-27
UniRef50_UPI00015A7C25 Cluster: UPI00015A7C25 related cluster; n... 124 9e-27
UniRef50_A7RVU0 Cluster: Predicted protein; n=1; Nematostella ve... 124 9e-27
UniRef50_P00528 Cluster: Tyrosine-protein kinase Src64B; n=6; En... 124 9e-27
UniRef50_UPI0000519AF4 Cluster: PREDICTED: similar to Abl tyrosi... 124 1e-26
UniRef50_Q7YZH7 Cluster: MBRTK2; n=1; Monosiga brevicollis|Rep: ... 124 1e-26
UniRef50_Q70W11 Cluster: Receptor tyrosine kinase X; n=1; Ciona ... 124 1e-26
UniRef50_A7SZN9 Cluster: Predicted protein; n=3; Nematostella ve... 124 1e-26
UniRef50_A7S4Y9 Cluster: Predicted protein; n=1; Nematostella ve... 124 1e-26
UniRef50_Q2VJ45 Cluster: HOOK3-RET fusion protein; n=3; Eutheria... 124 1e-26
UniRef50_P30530 Cluster: Tyrosine-protein kinase receptor UFO pr... 124 1e-26
UniRef50_UPI00015B4B0F Cluster: PREDICTED: similar to proto-onco... 123 1e-26
UniRef50_A7SP77 Cluster: Predicted protein; n=1; Nematostella ve... 123 1e-26
UniRef50_Q7Z1L9 Cluster: Neurite outgrowth regulated kinase; n=1... 123 2e-26
UniRef50_Q70W09 Cluster: Receptor tyrosine kinase VIII; n=1; Cio... 123 2e-26
UniRef50_Q008W6 Cluster: Gamma-carboxyglutamic acid protein 1; n... 123 2e-26
UniRef50_A7SAX2 Cluster: Predicted protein; n=3; Nematostella ve... 123 2e-26
UniRef50_Q15303 Cluster: Receptor tyrosine-protein kinase erbB-4... 123 2e-26
UniRef50_Q4JDD5 Cluster: Tyrosine-protein kinase receptor; n=5; ... 122 3e-26
UniRef50_Q7YXV8 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 122 3e-26
UniRef50_P51813 Cluster: Cytoplasmic tyrosine-protein kinase BMX... 122 3e-26
UniRef50_UPI0000D55B96 Cluster: PREDICTED: similar to Tyrosine-p... 122 3e-26
UniRef50_Q4RH14 Cluster: Chromosome undetermined SCAF15074, whol... 122 3e-26
UniRef50_Q86MD7 Cluster: EGF receptor; n=1; Echinococcus multilo... 122 5e-26
UniRef50_Q6R1Y3 Cluster: Src family kinase; n=6; Fungi/Metazoa g... 122 5e-26
UniRef50_Q17MF5 Cluster: Tyrosine-protein kinase; n=2; Culicidae... 122 5e-26
UniRef50_A7SE14 Cluster: Predicted protein; n=4; Nematostella ve... 122 5e-26
UniRef50_A7RNB2 Cluster: Predicted protein; n=1; Nematostella ve... 122 5e-26
UniRef50_P04412 Cluster: Epidermal growth factor receptor precur... 122 5e-26
UniRef50_UPI0000E48358 Cluster: PREDICTED: hypothetical protein;... 121 6e-26
UniRef50_UPI0000D57178 Cluster: PREDICTED: similar to CG14396-PA... 121 6e-26
UniRef50_UPI00015B51DA Cluster: PREDICTED: similar to ENSANGP000... 121 8e-26
UniRef50_UPI0000DB7A0A Cluster: PREDICTED: similar to FMS-like t... 121 8e-26
UniRef50_Q4H3M7 Cluster: Ephrin receptor; n=3; Ciona|Rep: Ephrin... 121 8e-26
UniRef50_A7S934 Cluster: Predicted protein; n=4; Nematostella ve... 121 8e-26
UniRef50_P34925 Cluster: Tyrosine-protein kinase RYK precursor; ... 121 8e-26
UniRef50_UPI0000D55DFF Cluster: PREDICTED: similar to Insulin-li... 120 1e-25
UniRef50_UPI00015A3FB5 Cluster: hypothetical protein LOC553690; ... 120 1e-25
UniRef50_Q9Y1Y7 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 120 1e-25
UniRef50_P24348 Cluster: Receptor tyrosine-protein kinase let-23... 120 1e-25
UniRef50_Q7YZX2 Cluster: Bruton's tyrosine kinase-like protein; ... 120 1e-25
UniRef50_Q7KJ08 Cluster: Receptor protein tyrosine kinase ALK sp... 120 1e-25
UniRef50_Q6SAA3 Cluster: Epidermal growth factor receptor; n=39;... 120 1e-25
UniRef50_Q06418 Cluster: Tyrosine-protein kinase receptor TYRO3 ... 120 1e-25
UniRef50_P42686 Cluster: Tyrosine-protein kinase isoform SRK1; n... 120 1e-25
UniRef50_UPI0000E471D0 Cluster: PREDICTED: similar to p80 protei... 120 2e-25
UniRef50_Q21038 Cluster: Putative uncharacterized protein ver-3;... 120 2e-25
UniRef50_O76148 Cluster: Tyrosine-protein kinase receptor; n=1; ... 120 2e-25
UniRef50_Q5GIT4 Cluster: Vascular endothelial growth factor rece... 120 2e-25
UniRef50_P00529 Cluster: Tyrosine-protein kinase transforming pr... 120 2e-25
UniRef50_Q9YI66 Cluster: Developmental receptor tyrosine kinase;... 119 2e-25
UniRef50_A7SI92 Cluster: Predicted protein; n=2; Nematostella ve... 119 2e-25
UniRef50_P35916 Cluster: Vascular endothelial growth factor rece... 119 2e-25
UniRef50_UPI00015B5C00 Cluster: PREDICTED: similar to VEGFR-A sp... 119 3e-25
UniRef50_Q5DM52 Cluster: Receptor tyrosine kinase Torso-like pro... 119 3e-25
UniRef50_P08922 Cluster: Proto-oncogene tyrosine-protein kinase ... 119 3e-25
UniRef50_Q25410 Cluster: Putative molluscan insulin-related pept... 119 3e-25
UniRef50_Q9PVZ4 Cluster: Insulin receptor precursor (EC 2.7.10.1... 119 3e-25
UniRef50_P41240 Cluster: Tyrosine-protein kinase CSK; n=21; Deut... 119 3e-25
UniRef50_UPI0000DB6DD4 Cluster: PREDICTED: similar to Insulin-li... 118 4e-25
UniRef50_P00521 Cluster: Tyrosine-protein kinase transforming pr... 118 4e-25
UniRef50_UPI0000E4736E Cluster: PREDICTED: similar to src-family... 118 6e-25
UniRef50_P04626 Cluster: Receptor tyrosine-protein kinase erbB-2... 118 6e-25
UniRef50_P00519 Cluster: Proto-oncogene tyrosine-protein kinase ... 118 6e-25
UniRef50_UPI0000F1EB7D Cluster: PREDICTED: hypothetical protein;... 118 7e-25
UniRef50_UPI0000DB6C99 Cluster: PREDICTED: similar to proto-onco... 118 7e-25
UniRef50_Q2LC18 Cluster: Tyrosine-protein kinase receptor; n=2; ... 118 7e-25
UniRef50_Q16RK6 Cluster: Receptor protein tyrosine kinase; n=1; ... 118 7e-25
UniRef50_P10447 Cluster: Tyrosine-protein kinase transforming pr... 118 7e-25
UniRef50_P42684 Cluster: Tyrosine-protein kinase ABL2; n=38; Eut... 118 7e-25
UniRef50_UPI0000DB72A0 Cluster: PREDICTED: similar to R151.4a; n... 117 1e-24
UniRef50_UPI0000D57520 Cluster: PREDICTED: similar to CG8250-PA;... 117 1e-24
UniRef50_UPI0000ECD739 Cluster: Cytoplasmic tyrosine-protein kin... 117 1e-24
UniRef50_Q4H3N2 Cluster: Epidermal growth factor receptor; n=1; ... 117 1e-24
UniRef50_Q13882 Cluster: Tyrosine-protein kinase 6; n=11; Mammal... 117 1e-24
UniRef50_UPI0000DB7735 Cluster: PREDICTED: similar to Insulin re... 117 1e-24
UniRef50_Q10656-2 Cluster: Isoform b of Q10656 ; n=4; Caenorhabd... 117 1e-24
UniRef50_Q259N0 Cluster: H0723C07.13 protein; n=4; Oryza sativa|... 117 1e-24
UniRef50_Q7Q0U2 Cluster: ENSANGP00000012311; n=1; Anopheles gamb... 117 1e-24
UniRef50_O16131 Cluster: Insulin receptor homolog precursor; n=2... 117 1e-24
UniRef50_P09208 Cluster: Insulin-like receptor precursor (EC 2.7... 117 1e-24
UniRef50_Q10656 Cluster: Myoblast growth factor receptor egl-15 ... 117 1e-24
UniRef50_Q9FIL6 Cluster: Protein-tyrosine kinase; n=10; core eud... 116 2e-24
UniRef50_O76698 Cluster: Vegf (Vascular endothelial growth facto... 116 2e-24
UniRef50_Q27324 Cluster: Tyrosine-protein kinase Drl precursor; ... 116 2e-24
UniRef50_UPI0000D57494 Cluster: PREDICTED: similar to insulin re... 116 2e-24
UniRef50_Q1HTP2 Cluster: Tyrosine-protein kinase receptor; n=4; ... 116 2e-24
UniRef50_Q9GRH2 Cluster: Tyrosine-protein kinase receptor; n=1; ... 116 2e-24
UniRef50_Q4H3N3 Cluster: Epidermal growth factor receptor; n=1; ... 116 2e-24
UniRef50_Q26566 Cluster: Epidermal growth factor receptor precur... 116 2e-24
UniRef50_UPI0000DB7330 Cluster: PREDICTED: similar to Ack CG1499... 116 3e-24
UniRef50_UPI0000D569CE Cluster: PREDICTED: similar to CG10023-PA... 116 3e-24
UniRef50_Q910A2 Cluster: Spleen protein tyrosine kinase; n=2; Da... 116 3e-24
UniRef50_Q5G254 Cluster: Erbb3; n=6; Danio rerio|Rep: Erbb3 - Da... 116 3e-24
UniRef50_P06213 Cluster: Insulin receptor precursor (EC 2.7.10.1... 116 3e-24
UniRef50_Q16620 Cluster: BDNF/NT-3 growth factors receptor precu... 115 4e-24
UniRef50_Q91987 Cluster: BDNF/NT-3 growth factors receptor precu... 115 4e-24
UniRef50_Q93105 Cluster: Insulin-like receptor precursor (EC 2.7... 115 4e-24
UniRef50_Q39886 Cluster: Protein kinase; n=7; Magnoliophyta|Rep:... 115 5e-24
UniRef50_O76695 Cluster: Vegf (Vascular endothelial growth facto... 115 5e-24
UniRef50_UPI00015B5971 Cluster: PREDICTED: similar to leukocyte ... 114 7e-24
UniRef50_UPI0000D5603D Cluster: PREDICTED: similar to Insulin re... 114 7e-24
UniRef50_A1IKE0 Cluster: Receptor tyrosine kinase-like orphan re... 114 7e-24
UniRef50_Q7T6Y2 Cluster: Putative serine/threonine-protein kinas... 114 7e-24
UniRef50_P42687 Cluster: Tyrosine-protein kinase SPK-1; n=1; Gir... 114 7e-24
UniRef50_UPI00015B5959 Cluster: PREDICTED: similar to insulin re... 114 9e-24
UniRef50_Q9U531 Cluster: Focal adhesion kinase homolog DFak56; n... 114 9e-24
UniRef50_O77132 Cluster: Non-receptor protein-tyrosine kinase CS... 114 9e-24
UniRef50_O02466 Cluster: Insulin-like peptide receptor precursor... 114 9e-24
UniRef50_UPI0000E47549 Cluster: PREDICTED: similar to Cek8; n=2;... 113 1e-23
UniRef50_Q9M085 Cluster: Protein kinase-like protein; n=22; Magn... 113 1e-23
UniRef50_Q9NH62 Cluster: Tyrosine kinase 5; n=2; Schistosoma man... 113 1e-23
UniRef50_Q9BL77 Cluster: C-terminal src kinase protein 1; n=2; C... 113 1e-23
UniRef50_Q6SAJ2 Cluster: Epidermal growth factor receptor; n=11;... 113 1e-23
UniRef50_Q21041 Cluster: Putative uncharacterized protein ver-4;... 113 1e-23
UniRef50_Q9H3Y6 Cluster: Tyrosine-protein kinase Srms; n=17; Amn... 113 1e-23
UniRef50_P29323 Cluster: Ephrin type-B receptor 2 precursor; n=3... 113 1e-23
UniRef50_UPI00004D7E5F Cluster: Proto-oncogene tyrosine-protein ... 113 2e-23
UniRef50_Q70W05 Cluster: Src protein; n=1; Ciona intestinalis|Re... 113 2e-23
UniRef50_O76809 Cluster: Receptor tyrosine kinase HTK30; n=1; Hy... 113 2e-23
UniRef50_O76385 Cluster: Putative uncharacterized protein; n=3; ... 113 2e-23
UniRef50_A7SFD8 Cluster: Predicted protein; n=2; Nematostella ve... 113 2e-23
UniRef50_P03949 Cluster: Tyrosine-protein kinase abl-1; n=5; Cae... 113 2e-23
UniRef50_UPI00015B54DC Cluster: PREDICTED: similar to vascular e... 113 2e-23
UniRef50_Q4RXA0 Cluster: Chromosome 11 SCAF14979, whole genome s... 113 2e-23
UniRef50_Q4RL31 Cluster: Chromosome undetermined SCAF15024, whol... 113 2e-23
UniRef50_A2CG59 Cluster: Eph receptor B1; n=23; Euteleostomi|Rep... 113 2e-23
UniRef50_Q9V4E5 Cluster: CG1511-PC, isoform C; n=12; Diptera|Rep... 113 2e-23
UniRef50_Q16XX9 Cluster: Tyrosine-protein kinase shark; n=2; Cul... 113 2e-23
UniRef50_P09619 Cluster: Beta-type platelet-derived growth facto... 113 2e-23
UniRef50_P29317 Cluster: Ephrin type-A receptor 2 precursor; n=3... 113 2e-23
UniRef50_UPI000069DB6A Cluster: Ephrin type-A receptor 6 precurs... 112 4e-23
UniRef50_Q4SMF1 Cluster: Chromosome 8 SCAF14552, whole genome sh... 111 5e-23
UniRef50_Q4SFJ9 Cluster: Chromosome 7 SCAF14601, whole genome sh... 111 5e-23
UniRef50_A7R2R7 Cluster: Chromosome chr4 scaffold_443, whole gen... 111 5e-23
UniRef50_Q17IF1 Cluster: Receptor protein tyrosine kinase; n=1; ... 111 5e-23
UniRef50_O77440 Cluster: Protein-tyrosine kinase HTK98; n=1; Hyd... 111 5e-23
UniRef50_UPI00015B55E4 Cluster: PREDICTED: similar to receptor-l... 111 6e-23
UniRef50_Q7Q0F6 Cluster: Tyrosine-protein kinase receptor; n=2; ... 111 6e-23
UniRef50_UPI00006A0D3B Cluster: Tyrosine protein-kinase STYK1 (E... 111 8e-23
UniRef50_UPI000065F647 Cluster: Ephrin type-B receptor 2 precurs... 111 8e-23
UniRef50_Q9Y1Y9 Cluster: Protein tyrosine kinase; n=3; Metazoa|R... 111 8e-23
UniRef50_Q9N3S5 Cluster: Putative uncharacterized protein; n=4; ... 111 8e-23
UniRef50_Q7Z1D3 Cluster: Focal adhesion kinase; n=1; Lytechinus ... 111 8e-23
UniRef50_Q7YZH5 Cluster: MBTK3; n=1; Monosiga brevicollis|Rep: M... 111 8e-23
UniRef50_Q6VU50 Cluster: Eph receptor; n=3; Endopterygota|Rep: E... 111 8e-23
UniRef50_Q4SQX3 Cluster: Chromosome 11 SCAF14528, whole genome s... 110 1e-22
UniRef50_Q9Y1X9 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 110 1e-22
UniRef50_Q25199 Cluster: Tyrosine kinase receptor; n=7; Hydra|Re... 110 1e-22
UniRef50_Q22489 Cluster: Putative uncharacterized protein; n=4; ... 110 1e-22
UniRef50_Q17LF1 Cluster: Muscle-specific tyrosine kinase recepto... 110 1e-22
UniRef50_Q05397 Cluster: Focal adhesion kinase 1; n=111; Euteleo... 110 1e-22
UniRef50_P29322 Cluster: Ephrin type-A receptor 8 precursor; n=2... 110 1e-22
UniRef50_UPI0000E47C0F Cluster: PREDICTED: similar to focal adhe... 110 1e-22
UniRef50_Q66I04 Cluster: Zgc:92124; n=1; Danio rerio|Rep: Zgc:92... 110 1e-22
UniRef50_Q4RWP2 Cluster: Tyrosine-protein kinase receptor; n=1; ... 110 1e-22
UniRef50_Q9Y1X8 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 110 1e-22
UniRef50_Q9VLQ8 Cluster: CG8222-PA, isoform A; n=8; Sophophora|R... 110 1e-22
UniRef50_Q8T4M0 Cluster: VEGFR-A splice form A; n=4; Diptera|Rep... 110 1e-22
UniRef50_P34891 Cluster: Receptor-like tyrosine-protein kinase k... 110 1e-22
UniRef50_P21860 Cluster: Receptor tyrosine-protein kinase erbB-3... 110 1e-22
UniRef50_Q5BXN9 Cluster: SJCHGC05493 protein; n=1; Schistosoma j... 109 2e-22
UniRef50_Q573B4 Cluster: Proto-oncogene tyrosine-protein kinase ... 109 2e-22
UniRef50_P79749 Cluster: Beta-type platelet-derived growth facto... 109 2e-22
UniRef50_UPI0000660568 Cluster: Ephrin type-B receptor 2 precurs... 109 3e-22
UniRef50_Q6PFV6 Cluster: Ephrin receptor; n=11; Tetrapoda|Rep: E... 109 3e-22
UniRef50_Q55A09 Cluster: Kelch repeat-containing protein; n=4; D... 109 3e-22
UniRef50_Q5Z986 Cluster: EDR1-like; n=3; Magnoliophyta|Rep: EDR1... 109 3e-22
UniRef50_UPI0000E47617 Cluster: PREDICTED: similar to muscle spe... 108 5e-22
UniRef50_UPI0000D8BE91 Cluster: UPI0000D8BE91 related cluster; n... 108 5e-22
UniRef50_Q4SQ93 Cluster: Tyrosine-protein kinase receptor; n=2; ... 108 5e-22
UniRef50_Q0IFX6 Cluster: Pdgf/vegf receptor; n=1; Aedes aegypti|... 108 5e-22
UniRef50_O17391 Cluster: Protein kinase protein 9, isoform b; n=... 108 5e-22
UniRef50_P08923 Cluster: Leukocyte tyrosine kinase receptor prec... 108 5e-22
UniRef50_Q15375 Cluster: Ephrin type-A receptor 7 precursor; n=5... 108 5e-22
UniRef50_P14616 Cluster: Insulin receptor-related protein precur... 108 6e-22
UniRef50_UPI00015B5A01 Cluster: PREDICTED: similar to protein ki... 107 8e-22
UniRef50_UPI0000E49042 Cluster: PREDICTED: similar to RE05926p; ... 107 8e-22
UniRef50_UPI0000DB6B52 Cluster: PREDICTED: similar to Ror CG4926... 107 8e-22
UniRef50_Q17C76 Cluster: Focal adhesion kinase; n=2; Culicidae|R... 107 8e-22
UniRef50_Q25197 Cluster: Putative insulin-like peptide receptor ... 107 8e-22
UniRef50_Q95YD4 Cluster: Protein kinase protein 32, isoform a; n... 107 1e-21
UniRef50_Q6TYB9 Cluster: Dauer abnormal formation-2 precursor; n... 107 1e-21
UniRef50_O61460 Cluster: Ephrin receptor 1 precursor; n=3; Caeno... 107 1e-21
UniRef50_P18475 Cluster: Tyrosine-protein kinase receptor torso ... 107 1e-21
UniRef50_P53356 Cluster: Tyrosine-protein kinase HTK16; n=1; Hyd... 107 1e-21
UniRef50_Q9I9L1 Cluster: Arg protein-tyrosine kinase; n=12; Tetr... 107 1e-21
UniRef50_Q5D184 Cluster: Ephrin receptor; n=2; Apocrita|Rep: Eph... 107 1e-21
UniRef50_UPI00015B4DC3 Cluster: PREDICTED: similar to receptor t... 106 2e-21
UniRef50_UPI0000E257E1 Cluster: PREDICTED: similar to tyrosine k... 106 2e-21
UniRef50_Q9U8U9 Cluster: PDGFR-like; n=1; Eptatretus burgeri|Rep... 106 2e-21
UniRef50_Q4RXV8 Cluster: Chromosome 11 SCAF14979, whole genome s... 106 2e-21
UniRef50_Q00Y29 Cluster: Protein kinase family protein; n=1; Ost... 106 2e-21
UniRef50_A4RXI8 Cluster: Predicted protein; n=2; Ostreococcus|Re... 106 2e-21
UniRef50_Q9XX42 Cluster: Putative uncharacterized protein; n=2; ... 106 2e-21
UniRef50_Q8T6F8 Cluster: SRC-1; n=3; Caenorhabditis|Rep: SRC-1 -... 106 2e-21
UniRef50_Q96HF4 Cluster: EPHA2 protein; n=3; Amniota|Rep: EPHA2 ... 106 2e-21
UniRef50_P34892 Cluster: Receptor-like tyrosine-protein kinase k... 106 2e-21
UniRef50_UPI0000E48523 Cluster: PREDICTED: similar to protein-ty... 106 2e-21
UniRef50_Q8WPV5 Cluster: Tyrosine kinase; n=2; Eumetazoa|Rep: Ty... 106 2e-21
UniRef50_Q24488 Cluster: Tyrosine-protein kinase transmembrane r... 106 2e-21
UniRef50_P54756 Cluster: Ephrin type-A receptor 5 precursor; n=1... 106 2e-21
UniRef50_UPI000049A16F Cluster: protein kinase; n=1; Entamoeba h... 105 3e-21
UniRef50_Q4SP88 Cluster: Ephrin receptor; n=2; Tetraodon nigrovi... 105 3e-21
UniRef50_Q4SFK0 Cluster: Chromosome 7 SCAF14601, whole genome sh... 105 3e-21
UniRef50_Q08BY6 Cluster: Zgc:153964; n=3; Danio rerio|Rep: Zgc:1... 105 3e-21
UniRef50_Q21868 Cluster: Putative uncharacterized protein; n=1; ... 105 3e-21
UniRef50_Q19238 Cluster: Putative tyrosine-protein kinase F09A5.... 105 3e-21
UniRef50_P04629 Cluster: High affinity nerve growth factor recep... 105 3e-21
UniRef50_UPI0000E47068 Cluster: PREDICTED: similar to tyrosine p... 105 4e-21
UniRef50_UPI00015A61DF Cluster: UPI00015A61DF related cluster; n... 105 4e-21
UniRef50_Q60I21 Cluster: TEC family protein tyrosine kinase; n=1... 105 4e-21
UniRef50_P16234 Cluster: Alpha-type platelet-derived growth fact... 105 4e-21
UniRef50_UPI0000D57699 Cluster: PREDICTED: similar to CG18247-PA... 105 6e-21
UniRef50_UPI00006A1DD3 Cluster: UPI00006A1DD3 related cluster; n... 105 6e-21
UniRef50_UPI000065E468 Cluster: Homolog of Gallus gallus "Ephrin... 105 6e-21
UniRef50_Q5YKK5 Cluster: CTR1-like protein kinase; n=12; core eu... 105 6e-21
UniRef50_A7Q5T6 Cluster: Chromosome chr14 scaffold_54, whole gen... 105 6e-21
UniRef50_Q4H3M4 Cluster: Ephrin receptor; n=2; Ciona intestinali... 105 6e-21
UniRef50_A2DXP4 Cluster: TKL family protein kinase; n=1; Trichom... 105 6e-21
UniRef50_Q7T6X2 Cluster: Putative serine/threonine-protein kinas... 105 6e-21
UniRef50_P43405 Cluster: Tyrosine-protein kinase SYK; n=23; Ther... 105 6e-21
UniRef50_Q2MHE4 Cluster: Serine/threonine-protein kinase HT1; n=... 105 6e-21
UniRef50_Q75I98 Cluster: Putative uncharacterized protein OSJNBa... 104 7e-21
UniRef50_A7P4M8 Cluster: Chromosome chr4 scaffold_6, whole genom... 104 7e-21
UniRef50_Q9XVQ7 Cluster: Putative uncharacterized protein; n=2; ... 104 7e-21
UniRef50_Q24145 Cluster: Tyrosine-protein kinase shark; n=2; Sop... 104 7e-21
UniRef50_P08631 Cluster: Tyrosine-protein kinase HCK; n=32; Eute... 104 7e-21
UniRef50_UPI00015B4A8D Cluster: PREDICTED: similar to receptor t... 104 1e-20
UniRef50_UPI000065E56D Cluster: EPHB1_HUMAN Isoform 3 of P54762 ... 104 1e-20
UniRef50_Q4SWL0 Cluster: Ephrin receptor; n=3; Tetraodontidae|Re... 104 1e-20
UniRef50_Q5I4E2 Cluster: Bm-DAF-2 precursor; n=1; Brugia malayi|... 104 1e-20
UniRef50_A2DI38 Cluster: TKL family protein kinase; n=2; Trichom... 104 1e-20
UniRef50_A6NNJ8 Cluster: Uncharacterized protein LTK; n=12; Euar... 104 1e-20
UniRef50_Q9V6K3 Cluster: Tyrosine-protein kinase transmembrane r... 104 1e-20
UniRef50_UPI00015B6067 Cluster: PREDICTED: similar to tyrosine p... 103 1e-20
UniRef50_UPI0000E47A46 Cluster: PREDICTED: similar to ret protei... 103 1e-20
UniRef50_Q4TBR4 Cluster: Chromosome undetermined SCAF7099, whole... 103 1e-20
UniRef50_Q4SS18 Cluster: Chromosome undetermined SCAF14482, whol... 103 1e-20
UniRef50_Q7Q5T3 Cluster: Tyrosine-protein kinase receptor; n=3; ... 103 1e-20
UniRef50_Q17JW1 Cluster: Tyrosine protein kinase; n=2; Culicidae... 103 1e-20
UniRef50_Q8AXY6 Cluster: Muscle, skeletal receptor tyrosine prot... 103 1e-20
UniRef50_Q4SK07 Cluster: Tyrosine-protein kinase receptor; n=2; ... 103 2e-20
UniRef50_Q7XTK4 Cluster: Putative mitogen-activated protein kina... 103 2e-20
UniRef50_UPI0000D55A9B Cluster: PREDICTED: similar to CG8789-PA,... 103 2e-20
UniRef50_Q98TD0 Cluster: Ephrin receptor; n=6; Amniota|Rep: Ephr... 103 2e-20
UniRef50_Q4SMB8 Cluster: Chromosome 3 SCAF14553, whole genome sh... 103 2e-20
UniRef50_Q9Y1Y6 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 103 2e-20
UniRef50_Q9Y1Y3 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 103 2e-20
UniRef50_Q8I7I5 Cluster: Roller: helically twisted, animals roll... 103 2e-20
UniRef50_O76411 Cluster: Suppressor of constitutive dauer format... 103 2e-20
UniRef50_P07947 Cluster: Proto-oncogene tyrosine-protein kinase ... 103 2e-20
UniRef50_P18161 Cluster: Tyrosine-protein kinase 2; n=2; Dictyos... 103 2e-20
UniRef50_P51451 Cluster: Tyrosine-protein kinase BLK; n=5; Eutel... 103 2e-20
UniRef50_UPI0000E468FC Cluster: PREDICTED: similar to KLG; n=3; ... 102 3e-20
UniRef50_Q4H3M5 Cluster: Ephrin receptor; n=1; Ciona intestinali... 102 3e-20
UniRef50_Q9V422 Cluster: Tyrosine-protein kinase Dnt precursor; ... 102 3e-20
UniRef50_O15146 Cluster: Muscle, skeletal receptor tyrosine prot... 102 3e-20
UniRef50_Q0DDD4 Cluster: Os06g0232100 protein; n=5; Oryza sativa... 102 4e-20
UniRef50_A2YAZ9 Cluster: Putative uncharacterized protein; n=1; ... 102 4e-20
UniRef50_Q54TM7 Cluster: Leucine-rich repeat-containing protein;... 102 4e-20
UniRef50_Q54H45 Cluster: Protein kinase, TKL group; n=1; Dictyos... 102 4e-20
UniRef50_Q14289 Cluster: Protein tyrosine kinase 2 beta; n=47; E... 102 4e-20
UniRef50_UPI0000F2052A Cluster: PREDICTED: similar to anaplastic... 101 5e-20
UniRef50_UPI00004D86FC Cluster: Tyrosine-protein kinase Tec (EC ... 101 5e-20
UniRef50_Q4SC90 Cluster: Chromosome undetermined SCAF14659, whol... 101 5e-20
UniRef50_A7PYX6 Cluster: Chromosome chr12 scaffold_38, whole gen... 101 5e-20
UniRef50_Q9BKL8 Cluster: Tyrosine-protein kinase receptor; n=2; ... 101 5e-20
UniRef50_O76997 Cluster: Putative neurotrophin receptor LTRK 1 p... 101 5e-20
UniRef50_Q5XPL8 Cluster: EDR1; n=5; BEP clade|Rep: EDR1 - Tritic... 101 7e-20
UniRef50_Q5W6K6 Cluster: Kinase domain containing protein; n=2; ... 101 7e-20
UniRef50_O65833 Cluster: TCTR2 protein; n=2; Solanum lycopersicu... 101 7e-20
UniRef50_Q52V39 Cluster: Tyrosine-protein kinase receptor; n=2; ... 101 7e-20
UniRef50_Q17PG3 Cluster: Tyrosine-protein kinase drl; n=5; Endop... 101 7e-20
UniRef50_A6P4V4 Cluster: Tyrosine-protein kinase receptor; n=2; ... 101 7e-20
UniRef50_Q9UF33 Cluster: Ephrin type-A receptor 6 precursor; n=5... 101 7e-20
UniRef50_Q8UVR8 Cluster: Macrophage colony-stimulating factor 1 ... 101 7e-20
UniRef50_Q9UM73 Cluster: ALK tyrosine kinase receptor precursor;... 101 7e-20
UniRef50_Q9FRR5 Cluster: F22O13.20; n=37; Eukaryota|Rep: F22O13.... 101 9e-20
UniRef50_Q8T0W6 Cluster: Putative insulin receptor precursor; n=... 101 9e-20
UniRef50_Q20933 Cluster: Putative uncharacterized protein; n=1; ... 101 9e-20
UniRef50_P21709 Cluster: Ephrin type-A receptor 1 precursor; n=1... 101 9e-20
UniRef50_Q0P4R9 Cluster: Discoidin domain receptor family, membe... 100 1e-19
UniRef50_Q9N4T2 Cluster: Putative uncharacterized protein Y50D4B... 100 1e-19
UniRef50_Q5MCM8 Cluster: Protein-tyrosine kinase; n=2; Anthomedu... 100 1e-19
UniRef50_Q9XZ66 Cluster: Tyrosine kinase receptor-related protei... 100 2e-19
UniRef50_A2DSI0 Cluster: TKL family protein kinase; n=2; Trichom... 100 2e-19
UniRef50_A2DQD6 Cluster: TKL family protein kinase; n=1; Trichom... 100 2e-19
UniRef50_Q16832 Cluster: Discoidin domain-containing receptor 2 ... 100 2e-19
UniRef50_UPI00015B6133 Cluster: PREDICTED: similar to protein ty... 99 2e-19
UniRef50_UPI0000584AF8 Cluster: PREDICTED: similar to Expressed ... 99 2e-19
UniRef50_Q012D5 Cluster: Tyrosine kinase specific for activated ... 99 2e-19
UniRef50_Q9TX48 Cluster: 220 kDa ABL-related protein tyrosine ki... 99 2e-19
UniRef50_Q17833 Cluster: Putative uncharacterized protein old-1;... 99 2e-19
UniRef50_O02064 Cluster: Putative uncharacterized protein; n=1; ... 99 2e-19
UniRef50_Q8JFR5 Cluster: Mast/stem cell growth factor receptor p... 99 2e-19
UniRef50_P36888 Cluster: FL cytokine receptor precursor; n=33; A... 99 2e-19
UniRef50_UPI0000DB6C79 Cluster: PREDICTED: similar to PTK7 prote... 100 3e-19
UniRef50_Q1HTP1 Cluster: Tyrosine-protein kinase receptor; n=1; ... 100 3e-19
UniRef50_Q1SMZ9 Cluster: Protein kinase; n=3; Viridiplantae|Rep:... 100 3e-19
UniRef50_Q9Y1Y8 Cluster: Protein tyrosine kinase; n=2; Metazoa|R... 100 3e-19
UniRef50_UPI0000DB6D22 Cluster: PREDICTED: similar to Alk CG8250... 99 4e-19
UniRef50_UPI000051AB92 Cluster: PREDICTED: similar to Fak-like t... 99 4e-19
UniRef50_Q10925-2 Cluster: Isoform b of Q10925 ; n=2; Caenorhabd... 99 4e-19
UniRef50_Q640T5 Cluster: Tyrosine-protein kinase receptor; n=2; ... 99 4e-19
UniRef50_Q9LRY7 Cluster: Similarity to protein kinase; n=3; Arab... 99 4e-19
UniRef50_Q54U31 Cluster: SH2 domain-containing protein; n=1; Dic... 99 4e-19
UniRef50_Q25198 Cluster: Receptor tyrosine kinase 90; n=1; Hydra... 99 4e-19
UniRef50_O17408 Cluster: Putative uncharacterized protein; n=1; ... 99 4e-19
UniRef50_A2FEP9 Cluster: TKL family protein kinase; n=1; Trichom... 99 4e-19
UniRef50_A2EHA2 Cluster: TKL family protein kinase; n=1; Trichom... 99 4e-19
UniRef50_Q10925 Cluster: Probable tyrosine-protein kinase kin-25... 99 4e-19
UniRef50_UPI00005A2D48 Cluster: PREDICTED: similar to EPH recept... 99 5e-19
UniRef50_UPI000065E2FA Cluster: Homolog of Homo sapiens "Tyrosin... 99 5e-19
UniRef50_Q4H3M3 Cluster: Ephrin receptor like protein; n=1; Cion... 99 5e-19
UniRef50_Q16VL6 Cluster: Tyrosine-protein kinase; n=1; Aedes aeg... 99 5e-19
UniRef50_O82754 Cluster: Putative serine/threonine kinase; n=2; ... 98 6e-19
UniRef50_Q9Y1Y2 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 98 6e-19
UniRef50_Q9VZI2 Cluster: CG14992-PA; n=3; Sophophora|Rep: CG1499... 98 6e-19
UniRef50_Q16UV1 Cluster: Protein kinase protein; n=3; Culicidae|... 98 6e-19
UniRef50_P43403 Cluster: Tyrosine-protein kinase ZAP-70; n=55; E... 98 6e-19
UniRef50_Q5JZY3 Cluster: Ephrin type-A receptor 10 precursor; n=... 98 6e-19
UniRef50_UPI00015B4221 Cluster: PREDICTED: similar to tyrosine-p... 98 8e-19
UniRef50_UPI0000D56EE8 Cluster: PREDICTED: similar to CG14992-PA... 98 8e-19
UniRef50_UPI000065FEDC Cluster: Activated CDC42 kinase 1 (EC 2.7... 98 8e-19
UniRef50_Q60WJ5 Cluster: Putative uncharacterized protein CBG191... 98 8e-19
UniRef50_Q5IJ68 Cluster: Trk-like receptor tyrosine kinase; n=1;... 98 8e-19
UniRef50_A7RN75 Cluster: Predicted protein; n=2; Nematostella ve... 98 8e-19
UniRef50_Q01973 Cluster: Tyrosine-protein kinase transmembrane r... 98 8e-19
UniRef50_UPI0000D56AE3 Cluster: PREDICTED: similar to CG1594-PA;... 97 1e-18
UniRef50_UPI0000499430 Cluster: protein kinase; n=1; Entamoeba h... 97 1e-18
UniRef50_Q8JFV0 Cluster: Tyrosine-protein kinase receptor; n=5; ... 97 1e-18
UniRef50_Q5RIU8 Cluster: Novel protein similar to vertebrate dis... 97 1e-18
UniRef50_Q4RQT4 Cluster: Chromosome 2 SCAF15004, whole genome sh... 97 1e-18
UniRef50_Q4RP85 Cluster: Tyrosine-protein kinase receptor; n=3; ... 97 1e-18
UniRef50_Q9Y1X7 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 97 1e-18
UniRef50_A2FCV2 Cluster: TKL family protein kinase; n=1; Trichom... 97 1e-18
UniRef50_A0D9Q7 Cluster: Chromosome undetermined scaffold_42, wh... 97 1e-18
UniRef50_UPI0000E49DC5 Cluster: PREDICTED: similar to angiopoiet... 97 2e-18
UniRef50_UPI0000D576E5 Cluster: PREDICTED: similar to CG33531-PA... 97 2e-18
UniRef50_Q4SF69 Cluster: Chromosome undetermined SCAF14608, whol... 97 2e-18
UniRef50_Q4RPK6 Cluster: Chromosome 12 SCAF15007, whole genome s... 97 2e-18
UniRef50_A0JMM7 Cluster: Zgc:154019; n=2; Danio rerio|Rep: Zgc:1... 97 2e-18
UniRef50_Q9Y1Y0 Cluster: Protein tyrosine kinase; n=1; Ephydatia... 97 2e-18
UniRef50_Q54TA1 Cluster: E set domain-containing protein; n=1; D... 97 2e-18
UniRef50_Q24327 Cluster: Gp160-Dtrk precursor; n=4; Sophophora|R... 97 2e-18
UniRef50_UPI00015B6363 Cluster: PREDICTED: similar to tyrosine p... 96 3e-18
UniRef50_Q4S1M5 Cluster: Chromosome 6 SCAF14768, whole genome sh... 96 3e-18
UniRef50_Q9LT56 Cluster: Nearly identical to protein kinase ATN1... 96 3e-18
UniRef50_Q9FPR5 Cluster: EDR1; n=6; Magnoliophyta|Rep: EDR1 - Or... 96 3e-18
UniRef50_Q01JS4 Cluster: OSIGBa0152L12.10 protein; n=4; Oryza sa... 96 3e-18
UniRef50_Q61BE3 Cluster: Putative uncharacterized protein CBG133... 96 3e-18
UniRef50_Q16RU6 Cluster: Mitogen-activated protein kinase kinase... 96 3e-18
UniRef50_A2EAR6 Cluster: TKL family protein kinase; n=1; Trichom... 96 3e-18
UniRef50_Q08345 Cluster: Epithelial discoidin domain-containing ... 96 3e-18
UniRef50_Q86LZ8 Cluster: Insulin receptor protein kinase; n=2; S... 96 3e-18
UniRef50_Q70W12 Cluster: Discoidin receptor; n=1; Ciona intestin... 96 3e-18
UniRef50_Q61BE2 Cluster: Putative uncharacterized protein CBG133... 96 3e-18
UniRef50_Q6J9G0 Cluster: Tyrosine protein-kinase STYK1; n=20; Am... 96 3e-18
UniRef50_UPI000155CF4D Cluster: PREDICTED: similar to EPH recept... 95 5e-18
UniRef50_UPI00006A26D5 Cluster: UPI00006A26D5 related cluster; n... 95 5e-18
UniRef50_Q4RY69 Cluster: Chromosome 3 SCAF14978, whole genome sh... 95 5e-18
UniRef50_Q4RU24 Cluster: Chromosome 12 SCAF14996, whole genome s... 95 5e-18
UniRef50_Q8LPH3 Cluster: MAP kinase, putative; n=8; Brassicaceae... 95 5e-18
UniRef50_Q9GRH1 Cluster: Tyrosine-protein kinase receptor; n=4; ... 95 5e-18
UniRef50_Q4L0H7 Cluster: Insulin receptor tyrosine kinase; n=2; ... 95 5e-18
UniRef50_Q05609 Cluster: Serine/threonine-protein kinase CTR1; n... 95 5e-18
UniRef50_UPI00015B6341 Cluster: PREDICTED: similar to KLG; n=1; ... 95 6e-18
UniRef50_Q4TFI7 Cluster: Chromosome undetermined SCAF4439, whole... 95 6e-18
UniRef50_O81472 Cluster: T15F16.3 protein; n=3; core eudicotyled... 95 6e-18
UniRef50_A7PH50 Cluster: Chromosome chr17 scaffold_16, whole gen... 95 6e-18
UniRef50_Q95ZV7 Cluster: Putative uncharacterized protein; n=3; ... 95 6e-18
UniRef50_Q7PT15 Cluster: ENSANGP00000009263; n=2; Culicidae|Rep:... 95 6e-18
UniRef50_Q55GU0 Cluster: Protein kinase, TKL group; n=1; Dictyos... 95 6e-18
UniRef50_Q9Y1Z4 Cluster: Protein tyrosine kinase 37; n=1; Hydra ... 95 8e-18
UniRef50_Q8WSM2 Cluster: Receptor tyrosine kinase; n=1; Schistos... 95 8e-18
UniRef50_Q54H46 Cluster: Protein kinase, TKL group; n=1; Dictyos... 95 8e-18
UniRef50_Q0MQ66 Cluster: Putative uncharacterized protein; n=5; ... 95 8e-18
UniRef50_A2FUJ1 Cluster: TKL family protein kinase; n=1; Trichom... 95 8e-18
UniRef50_UPI0000D5575B Cluster: PREDICTED: similar to CG10951-PA... 94 1e-17
UniRef50_Q61B52 Cluster: Putative uncharacterized protein CBG134... 94 1e-17
UniRef50_Q54XQ2 Cluster: RGS domain-containing protein; n=2; Dic... 94 1e-17
UniRef50_A2EC73 Cluster: TKL family protein kinase; n=1; Trichom... 94 1e-17
UniRef50_Q9I8N6 Cluster: Macrophage colony-stimulating factor 1 ... 94 1e-17
UniRef50_UPI0000E49AD1 Cluster: PREDICTED: similar to mixed line... 94 1e-17
UniRef50_UPI00006A1E7A Cluster: Non-receptor tyrosine-protein ki... 94 1e-17
UniRef50_Q8LCP3 Cluster: ATMRK1; n=27; Magnoliophyta|Rep: ATMRK1... 94 1e-17
UniRef50_Q5XTZ4 Cluster: Salt-inducible protein kinase; n=2; Poa... 94 1e-17
UniRef50_A7QKI2 Cluster: Chromosome chr2 scaffold_112, whole gen... 94 1e-17
UniRef50_A7NXT1 Cluster: Chromosome chr5 scaffold_2, whole genom... 94 1e-17
UniRef50_O01700 Cluster: Putative uncharacterized protein dlk-1;... 94 1e-17
UniRef50_Q12852 Cluster: Mitogen-activated protein kinase kinase... 94 1e-17
UniRef50_UPI00004986C0 Cluster: protein kinase; n=1; Entamoeba h... 93 2e-17
UniRef50_Q4TEC1 Cluster: Chromosome undetermined SCAF5507, whole... 93 2e-17
UniRef50_Q4T272 Cluster: Chromosome undetermined SCAF10323, whol... 93 2e-17
UniRef50_O64768 Cluster: Putative uncharacterized protein At2g35... 93 2e-17
UniRef50_A7QMH3 Cluster: Chromosome chr19 scaffold_126, whole ge... 93 2e-17
>UniRef50_UPI0000D560EA Cluster: PREDICTED: similar to CG31127-PA;
n=1; Tribolium castaneum|Rep: PREDICTED: similar to
CG31127-PA - Tribolium castaneum
Length = 721
Score = 484 bits (1194), Expect = e-135
Identities = 257/725 (35%), Positives = 401/725 (55%), Gaps = 17/725 (2%)
Query: 7 RIFVIILLCFAACLCERGDYIGCY-VLKAEEVLNTHTGQSVDACLNACEQVHYKYALIGN 65
++++I+ L A +R + GCY + + + N S + C+N C+ +Y+YA++ N
Sbjct: 3 KLYLILFLSTALSADDR--FKGCYKTIFSTQTYNVSWTTS-EQCINECKTRYYRYAMVQN 59
Query: 66 ESTCFCGNSPGKFKLPLDSCHTVCPKNETQKCGGNNATSVYDTDVVAPGQPSNLVLFNAT 125
+C+CGN G+ SC +C C +N T V+ T + PG P + L N T
Sbjct: 60 ARSCYCGNYLGEEVNNTLSCDQICDGF----C--DNVTDVFATGNLVPGPPEEVKLTNVT 113
Query: 126 ETTVRLRWSAPNAYSFITSYVIRAAVIETYSDYNLKPLEWRVSNETLNMELLNLHPGSKY 185
+++ + W P +Y+ I YVI+A VI TY++Y EW N+T + +++ L P +KY
Sbjct: 114 DSSAHISWKPPKSYTKINGYVIKATVIHTYANYIPNSPEWSYLNDTFSTKIILL-PATKY 172
Query: 186 NISVAALNYDEEGPNITMVTETVIGTPDPSPPDVEIIQRRGDRMVVHIPKAKNVNGPVSM 245
N+++ AL+ D G + V ET + P+ P II+R GDRM + + + N NGP++
Sbjct: 173 NVTLCALSPDGCGAPFSRVIETEVREPENPPESPNIIKRDGDRMEIELSETSNSNGPITS 232
Query: 246 YRIVISIELYQQGFIVDTLSNHTYATEQGLPYYITAELDPDDIKTDFIIGDRSTYNGFYN 305
Y +++ + QQ F D+L ++ A +G+ YYITAEL P++I+ FI+GD++ Y +YN
Sbjct: 233 YLVIVFNDDSQQIFQEDSLKSYYEAKREGINYYITAELKPENIQRRFIVGDKNYYGKYYN 292
Query: 306 APLPLTNDIDVSLGVVSEKNHVRKVRYAESTKKIILNINEPEEVS---PMVXXXXXXXXX 362
APL + +G+VS N K ++ E EVS P V
Sbjct: 293 APLETNVHYSIIIGLVSTLNGKTKRAFSSLKHTDTDGTEEFIEVSGDSPAVIIGLSVAIG 352
Query: 363 XXXXXXXXXXXXXXXXXXXQFVRMQRGSQSMPLSLSEPCVEIENSGFILEDEE-RVDYYG 421
R QR S++ L+L P +E+EN+G+I E+E +V YY
Sbjct: 353 LLSFMFIAGIIGFIILKSRVTTRRQRLSENQELTLQGPMIEVENNGYIPEEEHTKVSYYR 412
Query: 422 NLKRKLWNIPRNLIETDISCVVGVGTYXXXXXXXXXXXXXXXXXXXXXIADRELEKTEKK 481
+LK+K+ IP N ++ + + ++G+G + I D++L +KK
Sbjct: 413 DLKQKVRTIPYNQLKVEPTNLLGIGRFGRVNSGSIYENSTLIPVAVYSIQDKKLSADDKK 472
Query: 482 QMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNKFC 541
ML++LD+LIKT +H+NVI+L+G CET+ + VVLE + LK++LL SR D KF
Sbjct: 473 NMLRDLDVLIKTRKHDNVIALVGTCETSQMVFVVLEYVSMNLKDLLLGSR--DSLPGKFS 530
Query: 542 SITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSLHET 601
++TEN+ L I + VA+GM +L + KI+HK+LC RN++++ KI+G+GLS S +
Sbjct: 531 NMTENQALDIAINVAKGMSHLASNKIIHKQLCARNVMVANGFIPKISGYGLSQFYSHNNL 590
Query: 602 PDYTRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRILRGMRPS 661
PDYTRWT+ E+ + +N K+DVWSFG L+WE+ LG TPY + N ++ RI++G+R
Sbjct: 591 PDYTRWTAMEVFKGQAHNLKSDVWSFGCLLWEICVLGGTPYGNFSNNEIPERIIKGLRLP 650
Query: 662 QPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEAPGTRNLSFTHYNGFEFEPHI 721
Q Y DEL+Q L CWQ+D DERP F L+ L F E LSF Y F++E
Sbjct: 651 QMQYFSDELYQFMLSCWQIDMDERPDFDVLLESLQTFQENSLIPCLSFNLYPNFQYEQFY 710
Query: 722 PQYEV 726
P E+
Sbjct: 711 PDMEI 715
>UniRef50_P83097 Cluster: Putative tyrosine-protein kinase Wsck
precursor; n=2; Sophophora|Rep: Putative
tyrosine-protein kinase Wsck precursor - Drosophila
melanogaster (Fruit fly)
Length = 791
Score = 292 bits (717), Expect = 2e-77
Identities = 200/752 (26%), Positives = 347/752 (46%), Gaps = 54/752 (7%)
Query: 26 YIGCYVLKAEEVLNTHTGQSVDACLNACEQVHYKYALIGNESTCFCGNS-PGKFKLPLDS 84
Y+GCY + + + + ++ C+ CE + YA++ +E CFC N + +
Sbjct: 42 YVGCYTARTDLLHESVYAKTPQTCIEICEHQGHHYAVLASEK-CFCANVLEPQEQQDEQL 100
Query: 85 CHTVCPKNETQKCGGNNATSVYDTDVVAPGQPSNLVLFNATETTVRLRWSAPNAYSFITS 144
C+T C N+ Q CGG S Y T + P +L + N TE ++ L W+A A + +
Sbjct: 101 CNTRCLANKAQYCGGVGVHSYYSTILTKQPGPHHLRISNKTENSLTLSWNAYEARKLLLA 160
Query: 145 --------------YVIRAAVIETYSDYNLKPL-EWRVSNETLNMELLNLHPGSKYNISV 189
++I+A V++TYS P E+ V + EL +LHP + YNISV
Sbjct: 161 GGAEAVLPNQLLDNFLIKAQVLKTYSSLPAFPQPEFMVQSTETQFELTDLHPATLYNISV 220
Query: 190 AALNYD-----EEGPNITMVTETVIGTPDPSPPDVEIIQRRGDRMVVHIPKAKNVNGPVS 244
A+ D E ++ T +G P P P +I+ R + + + +N NGP+S
Sbjct: 221 RAMCKDAQVGQSECGQASIEATTEVGLPSPVPAQPKILSRTDRTVTIELSPIRNDNGPLS 280
Query: 245 MYRIVISI--ELYQQGFIVDTLSNHTYATEQGLPYYITAELD---PDDIKTD-FIIGDRS 298
+++ Q F L + A + G+PYYI AELD P+D +T F++GD
Sbjct: 281 KLLVIVEYVDNALSQPFDAQLLGSWQQAQQDGVPYYIAAELDYDRPEDNRTRRFVVGDGK 340
Query: 299 TYNGFYNAPLPLTN-DIDVSLGVVSEKNHVRKVRYAESTKKIILNINEPEEVSPMVXXXX 357
Y F N PL + + +SLG+VS V K Y+ T ++ ++ S
Sbjct: 341 RYGRFTNKPLDQPDAHVHISLGLVSTLEGVTKTMYSRGTHD--QHVTSLDDFSYATFEKG 398
Query: 358 XXXXXXXXXXXXXXXXXXXXXXXXQFV--------RMQRGSQSMPLSLSEPCVEIENSGF 409
F R G + ++L P +E EN+G+
Sbjct: 399 QSSVVALAVTCVIFGSCLLLSLIAYFYLRYKTCRGRRLTGGNTHEMTLQTPIIERENNGY 458
Query: 410 ILEDEERVDYYGNLKRKLWN-------IPRNLIETDISCVVGVGTYXXXXXXXXXXXXXX 462
++ED+ N K++L IPRN + +++ V+G G +
Sbjct: 459 LVEDDPLPHSPENFKQQLQQLVEGYERIPRNALRLNVNDVIGDGRFGEIITGKVSTNDFA 518
Query: 463 XXXXXXXIADRELEKTEKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKT 522
+ +L T + Q+L+EL L + E+++ G+ + ++ E + +
Sbjct: 519 RDCTLHVLCLDDLNGTTQAQLLRELRQLSQLKRQEHLLDFYGVSASPDWFYLIFEQQRMS 578
Query: 523 LKEMLLLSRQRDIQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISEN 582
LK L+ SR + + S++E VLQ ++A M YL + ++VH++LC ++ ++ +
Sbjct: 579 LKRKLVESRLM-APSPRLTSLSEQLVLQWIYELASAMNYLSSCQVVHRQLCSHSVFVTSD 637
Query: 583 GTVKIAGFG-LSHLRSLHETPDYTRWTSHEMLR-QTRYNPKADVWSFGVLMWEVLTLGAT 640
+K++ FG L ++ + PD+ RW + E+LR Q ++ ++DVWS + WE LG T
Sbjct: 638 FKLKLSVFGPLPYMNIARQQPDHNRWLAPEVLRHQHHHSTRSDVWSLACVAWECCALGGT 697
Query: 641 PYSHS--GNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPF 698
PY+++ N+ + I +RP+QP+YV +L+Q+ L CWQ++P ER + + +
Sbjct: 698 PYANAVASNQQLLEAIRAAVRPAQPAYVYGDLYQLLLNCWQLEPSERSSCEDVAFGVRQL 757
Query: 699 SEAPGTRNLSFTHYNG--FEFEPHIPQYEVIS 728
+P LSF G P++PQ E ++
Sbjct: 758 MTSP-RHALSFDRVAGGLDTLPPYLPQLEAVA 788
>UniRef50_Q7QIM9 Cluster: ENSANGP00000021621; n=3; Culicidae|Rep:
ENSANGP00000021621 - Anopheles gambiae str. PEST
Length = 609
Score = 274 bits (672), Expect = 5e-72
Identities = 181/611 (29%), Positives = 289/611 (47%), Gaps = 28/611 (4%)
Query: 142 ITSYVIRAAVIETYSDYNLKPLEWRVSNETLNMELLNLHPGSKYNISVAALNYDEEGPNI 201
+ + I A TY+ + + P+ W V N + EL NL PG+ YNI+V +++ G
Sbjct: 2 VEEFEIVAEATRTYASFRIYPVRWSVHNTSTGFELSNLQPGTDYNITVVSVSARGAGGRA 61
Query: 202 TMVTETVIGTPDPSPPDVEIIQRRGDRMVVHIPKAKNVNGPVSMYRIVI---SIELYQQG 258
++ T IG PDP P + I++R +++ IP+A N NGPV+ YR+V+ + EL QQ
Sbjct: 62 SIAGSTEIGHPDPEPEEPIILRRFESTILIQIPRAVNDNGPVNYYRVVVHYVNSELIQQ- 120
Query: 259 FIVDTLSNHTYATEQGLPYYITAELD-PDDIKTDFIIGDRSTYNGFYNAPLPLTNDIDVS 317
L + E +PYYI AEL+ DD F +GD Y ++N P+ + +S
Sbjct: 121 IDESQLGTFQQSKENKVPYYIAAELEMKDDESLQFTVGDGREYRSYFNPPITARTHVHIS 180
Query: 318 LGVVSEKNHVRKVRYAESTKKIILNINEPEEVSPMVXXXXXXXXXXXXXXXXXXXXXXXX 377
+GVVS NHV KVRYA +T + E E + V
Sbjct: 181 IGVVSILNHVVKVRYA-TTTHEQHHYFEFECLCLFVFSERNETLIAILTTACILFGVVLT 239
Query: 378 XXXXQFVRMQ---RGSQSMP------LSLSEPCVEIENSGFILEDEERVDYYGNLK---- 424
+V + + + P L+L P +E+EN+G++ + E+ + L+
Sbjct: 240 GAIILYVYLHFKTPAANTRPFGDHHELTLQGPILEVENNGYMPDIYEQRGFEAELRDIIE 299
Query: 425 --RKLWNIPRNLIETDISCVVGVGTYXXXXXXXXXXXXXXXXX--XXXXIADRELEKTEK 480
N R + DI+ V+G G Y + ++E ++
Sbjct: 300 GLEPAKNHARKYLSLDINRVLGSGKYGDVLLGALQLSQEQDGDMPAQVHVITDDMESVDQ 359
Query: 481 KQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNN-K 539
L E L H NVI G+C T ++ E ++ TLK+ LL +R N+ K
Sbjct: 360 IAFLNEFRRLTALEGHANVILFYGVCVTPDWCYLLFEQMQTTLKQTLLNARVPASANSVK 419
Query: 540 FCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSLH 599
F +I+E V+ I V GM++L +V KKLC R + ++ VK++ FG
Sbjct: 420 FSTISEEIVVNILCLVCDGMQFLADNNVVSKKLCARTVYVNTKFEVKVSAFGPPLNAEDT 479
Query: 600 ETP-DYTRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRILRGM 658
+P +RW + E+++ ++ K+DVWSFG+L+WE LGATPY + ++ + I G
Sbjct: 480 GSPIAISRWHAPEVIKFQNHSTKSDVWSFGLLIWECCCLGATPYGTTTTDNLFAAIRAGQ 539
Query: 659 RPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEAPGTRN-LSFTHYNGFEF 717
+P +PS++ ++L+Q+CL CW +D +RP+F L L P R LSF +
Sbjct: 540 KPERPSFMYEDLYQLCLNCWDLDASDRPSFDDLRRYLR--QTLPMLRYLLSFERKQNVQL 597
Query: 718 EPHIPQYEVIS 728
P++P E S
Sbjct: 598 PPYLPHLEAAS 608
>UniRef50_UPI0000DB6D34 Cluster: PREDICTED: similar to Wsck
CG31127-PA; n=1; Apis mellifera|Rep: PREDICTED: similar
to Wsck CG31127-PA - Apis mellifera
Length = 323
Score = 198 bits (482), Expect = 6e-49
Identities = 115/321 (35%), Positives = 178/321 (55%), Gaps = 13/321 (4%)
Query: 386 MQRGSQSMPLSLSEPCVEIENSGFILED-EERVDYYGNLKRKLWNIPRNLIETDISCVVG 444
M++ + L+L P E++N +I ED ER++YY LK+K+W IP+NL+ + V+
Sbjct: 1 MRKLPEQQELTLQGPLYEVDNLAYIPEDVPERINYYQELKKKVWIIPQNLLTIN-DTVIR 59
Query: 445 VGTYXXXXXXXXXXXXXXXXXXXXXIADRELEKTEKKQMLQELDLLIKTSEHENVISLIG 504
G + IAD+ L+ ++K+ ML+ELD+ IK S + + L+G
Sbjct: 60 RGRFGTVHTGAIEENGKFSTVAIHSIADKLLKASDKRHMLRELDVCIKVSPMKYLADLVG 119
Query: 505 ICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNKFCSITENKVLQICVQVARGMEYLHT 564
CET+ TL +VLE +TLK LL +R +I K+L I +A +++L
Sbjct: 120 TCETHDTLHIVLELPPQTLKNCLLAARSGNI-------FPVEKILSIGSMIASALQHLEN 172
Query: 565 RKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSLHETPDYTRWTSHEMLRQTRYNPKADV 624
KI+H+ LC R++ +S K+ G G+S + E Y RWTS E L + + A V
Sbjct: 173 YKIIHEHLCARSIGLSNEWIPKVMGHGIS--KYALEDMKYIRWTSIECLDNKKKHQPAVV 230
Query: 625 WSFGVLMWEVLTLGATPYSH-SGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPD 683
W+FGVL+WE+L++G TPYS+ S + +V I++G+R Q S + D L++V CW ++
Sbjct: 231 WAFGVLLWEMLSMGGTPYSNLSLDSEVEEAIVQGVRLPQLSDIPDPLYEVISSCWNIESH 290
Query: 684 ERPTFSSLVIELTPFSEAPGT 704
ERPTF+ L I L S P T
Sbjct: 291 ERPTFTEL-IRLETLSICPIT 310
>UniRef50_Q4RJ67 Cluster: Chromosome 1 SCAF15039, whole genome
shotgun sequence; n=2; Tetraodontidae|Rep: Chromosome 1
SCAF15039, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 978
Score = 149 bits (362), Expect = 2e-34
Identities = 78/236 (33%), Positives = 128/236 (54%), Gaps = 11/236 (4%)
Query: 477 KTEKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKK-TLKEMLLLSRQRDI 535
+ + + EL++L K +H N+I+LIG CE L + +E L + L SR +
Sbjct: 718 ENDHRDFAGELEVLCKLGQHPNIINLIGACENRGYLYIAIEYAPYGNLLDFLRKSRVLET 777
Query: 536 ------QNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAG 589
++ ++T ++LQ V VA GM YL ++ +H+ L RN+++ +N KIA
Sbjct: 778 DPAFAKEHGTASTLTSQQLLQFAVDVATGMHYLSDKQFIHRDLAARNVLVGDNLVAKIAD 837
Query: 590 FGLSHLRSLHETPDY----TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHS 645
FGLS ++ RW + E L + Y K+DVWSFGVL+WE+++LG TPY
Sbjct: 838 FGLSRGEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGM 897
Query: 646 GNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEA 701
++ ++ +G R +P DE++++ QCW+ P ERP FS + ++L+ EA
Sbjct: 898 TCAELYEKLPQGFRMEKPKNCDDEVYELMKQCWRDRPYERPPFSQISVQLSRMQEA 953
>UniRef50_A7RNB1 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 280
Score = 148 bits (359), Expect = 5e-34
Identities = 86/277 (31%), Positives = 140/277 (50%), Gaps = 17/277 (6%)
Query: 428 WNIPRNLIETDISCVVGVGTYXXXXXXXXXXXXXXXXXXXXXIADRELEKTEKKQMLQEL 487
W IPR+ + + +G G + + + ++T+ K ML+EL
Sbjct: 1 WEIPRDRVV--LKDKLGEGEFGIVMEGELLIEEEAPRKVAIKMLKSDADRTDHKDMLREL 58
Query: 488 DLLIKTSEHENVISLIGICETNTTLLVVLEDIKK-TLKEMLLLSR---QRDIQNNKFCSI 543
D+ +HENV+SLIG C L ++ E I TL E+L SR + N +
Sbjct: 59 DMFKGIGQHENVVSLIGACTLGMPLYIITEFIAGGTLLELLRESRCITSSYVNANLVSKL 118
Query: 544 TENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSLHETPD 603
+ +L++ + ARGM ++ + VH+ L RN++++E+ T KI FGLS R ++
Sbjct: 119 SGKDLLKLALGAARGMRHISGNRFVHRDLATRNVLVTEDLTAKITDFGLS--RDIYSDGI 176
Query: 604 YT---------RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRI 654
Y +W + E L Y ++D+WSFGVLMWEV + GA PYS ++ S +
Sbjct: 177 YLNAKGGKLPLKWMAPESLLDYVYTTQSDIWSFGVLMWEVWSFGAMPYSAVVPNELLSML 236
Query: 655 LRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSL 691
+ G R S+P +E++ V + CW +P+ RP+F+ L
Sbjct: 237 MSGFRLSRPPLCPEEIYDVMMSCWNAEPEVRPSFAKL 273
>UniRef50_UPI00015B4CAE Cluster: PREDICTED: similar to
ENSANGP00000019144; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000019144 - Nasonia
vitripennis
Length = 1220
Score = 146 bits (353), Expect = 2e-33
Identities = 81/235 (34%), Positives = 126/235 (53%), Gaps = 13/235 (5%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIK--KTLKEMLLLSRQRDIQ 536
EK+ +++EL+++ + H NV++L+G C ++LE + K L + ++D
Sbjct: 967 EKEDLVRELEIMQRVGSHPNVVTLLGCCTEQEPHYLILEYVMYGKLLAYLRDHRTRQDFY 1026
Query: 537 N--NKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSH 594
N ++T + VARGMEYL ++KI+H+ L RN+++ N KIA FG+S
Sbjct: 1027 NFSEDSAALTSRDLTVFGYCVARGMEYLASKKIIHRDLAARNVLVDHNKLCKIADFGMSR 1086
Query: 595 LRS----LHETPDYT-----RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHS 645
+ + ET RW + E L + + K DVWSFG+LMWE++TLG+TPY
Sbjct: 1087 FANEDGEVIETRHGRNALPIRWMAPESLIYSLFTTKTDVWSFGILMWEIVTLGSTPYPDM 1146
Query: 646 GNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSE 700
++V + G R +PS+ ELF+V +CW DPD RP F L +L E
Sbjct: 1147 TAREVMRSVQSGYRLERPSHCRSELFRVIARCWHADPDRRPEFQLLRRDLAQLLE 1201
>UniRef50_Q02763 Cluster: Angiopoietin-1 receptor precursor; n=41;
Euteleostomi|Rep: Angiopoietin-1 receptor precursor -
Homo sapiens (Human)
Length = 1124
Score = 144 bits (349), Expect = 7e-33
Identities = 79/252 (31%), Positives = 133/252 (52%), Gaps = 12/252 (4%)
Query: 477 KTEKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKK-TLKEMLLLSRQRD- 534
K + + EL++L K H N+I+L+G CE L + +E L + L SR +
Sbjct: 863 KDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLET 922
Query: 535 -----IQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAG 589
I N+ +++ ++L VARGM+YL ++ +H+ L RN+++ EN KIA
Sbjct: 923 DPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIAD 982
Query: 590 FGLSHLRSLHETPDY----TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHS 645
FGLS + ++ RW + E L + Y +DVWS+GVL+WE+++LG TPY
Sbjct: 983 FGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGM 1042
Query: 646 GNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEAPGTR 705
++ ++ +G R +P DE++ + QCW+ P ERP+F+ +++ L E T
Sbjct: 1043 TCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKT- 1101
Query: 706 NLSFTHYNGFEF 717
++ T Y F +
Sbjct: 1102 YVNTTLYEKFTY 1113
Score = 36.7 bits (81), Expect = 2.2
Identities = 23/84 (27%), Positives = 42/84 (50%), Gaps = 5/84 (5%)
Query: 111 VAPGQPSNLVLFNATETTVRLRWSAPNAYSFITSYVIRAAVIETYSDYNLKPLEWRVSNE 170
+ P QP N+ + N T ++ + W+ + YS I+S IR V D + ++ ++ N
Sbjct: 637 ILPPQPENIKISNITHSSAVISWTILDGYS-ISSITIRYKVQGKNEDQH---VDVKIKNA 692
Query: 171 T-LNMELLNLHPGSKYNISVAALN 193
T + +L L P + Y + + A N
Sbjct: 693 TIIQYQLKGLEPETAYQVDIFAEN 716
>UniRef50_P79950 Cluster: Tyrosine kinase receptor; n=3; Xenopus|Rep:
Tyrosine kinase receptor - Xenopus laevis (African clawed
frog)
Length = 1369
Score = 143 bits (347), Expect = 1e-32
Identities = 97/299 (32%), Positives = 148/299 (49%), Gaps = 26/299 (8%)
Query: 430 IPRNLIETDISCVVGVGTYXXXXXXXXXXXXXXXXXXXXXIADRELEKTEKKQMLQELDL 489
IP + T ++G G + +R + E ++ L+E +
Sbjct: 1050 IPERCLTTHRDRIIGKGHFGSVYHGTYVDEDQQEVHCAVKSLNRITDLEEVEEFLRE-GI 1108
Query: 490 LIKTSEHENVISLIGICETNTTL-LVVLEDIKKTLKEMLLLSRQRDIQNNKFCSITENKV 548
L+K+ H NV+SLIGIC L LVVL +K + S +R+ T +
Sbjct: 1109 LMKSFHHPNVLSLIGICLPQEGLPLVVLPFMKHGDLRHFIRSEERNP--------TVKDL 1160
Query: 549 LQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSLHETPDYT--- 605
+ +QV+RGMEYL RK VH+ L RN ++ E+ VK+A FGL+ R + + Y+
Sbjct: 1161 VGFGLQVSRGMEYLANRKFVHRDLAARNCMLDESFHVKVADFGLA--RDVFDKEYYSVRR 1218
Query: 606 --------RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRILRG 657
+W + E L+ ++ K+DVWSFGVL+WE++T GA PY D+ + RG
Sbjct: 1219 HKNARLPVKWMAMESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVDAYDITRYLFRG 1278
Query: 658 MRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEA-PGTR--NLSFTHYN 713
R +QP Y + L+ + L CW P ERPTF+ LV ++ S + G NL+ T+ N
Sbjct: 1279 RRLAQPEYCPNPLYSLMLSCWNPQPVERPTFTQLVSDMELISNSLSGDHYINLNVTYVN 1337
>UniRef50_Q7PYY7 Cluster: ENSANGP00000019144; n=1; Anopheles gambiae
str. PEST|Rep: ENSANGP00000019144 - Anopheles gambiae
str. PEST
Length = 687
Score = 143 bits (347), Expect = 1e-32
Identities = 83/285 (29%), Positives = 136/285 (47%), Gaps = 15/285 (5%)
Query: 421 GNLKRKLWNIPRNLIETDISCVVGVGTYXXXXXXXXXXXXXXXXXXXXXIAD--RELEKT 478
G++ + W PR+ ++ + ++G G + + +
Sbjct: 370 GSIVKDRWEFPRHRLK--VFNILGEGAFGQVWRCEATDIDGHEGVSVTAVKTLKENASEA 427
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKK-TLKEMLLLSRQRDIQN 537
E+ +L EL +L H NV+ L+G C + V+LE + L+ L SR
Sbjct: 428 ERNDLLSELQVLKSLEPHINVVRLLGCCTEKDPIFVILEYVNMGKLQTFLRNSRVEKHYG 487
Query: 538 N---KFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSH 594
N K +T + QVARGM++L +R I+H+ L RN++I+++ T K+A FG +
Sbjct: 488 NTHGKSKILTSGDLTSFMYQVARGMDFLTSRGIIHRDLAARNILITDDHTCKVADFGFAR 547
Query: 595 ---LRSLHETPDY----TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGN 647
++E RW + E L + K+D+WSFG+LMWE++TLG+TPY
Sbjct: 548 DIVTSKVYERKSEGRLPIRWMATESLYDNIFTVKSDIWSFGILMWEIVTLGSTPYPGIAA 607
Query: 648 KDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLV 692
DV ++ G R +P + EL+ + CW DP+ERP F +V
Sbjct: 608 ADVMRKVRDGYRLEKPEHCRRELYNIMFYCWAADPNERPGFPEVV 652
>UniRef50_Q9VBW3 Cluster: Tyrosine kinase receptor Cad96Ca
precursor; n=2; Diptera|Rep: Tyrosine kinase receptor
Cad96Ca precursor - Drosophila melanogaster (Fruit fly)
Length = 773
Score = 143 bits (347), Expect = 1e-32
Identities = 76/227 (33%), Positives = 124/227 (54%), Gaps = 11/227 (4%)
Query: 477 KTEKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKK-TLKEMLLLSR-QRD 534
+ ++K +L EL+++ H NV+ L+G C V+LE + + L+ L SR +R
Sbjct: 512 EVDRKDLLSELEVMKSLEPHINVVHLLGCCTDKDPTFVILEYVNRGKLQTYLRSSRAERH 571
Query: 535 IQNN--KFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGL 592
N K +T + QVA+GM+YL +R I+H+ L RN++I+++ T K+A FG
Sbjct: 572 YGNTHGKSNVLTSCDLTSFMYQVAKGMDYLTSRGIIHRDLAARNILITDDHTCKVADFGF 631
Query: 593 SH---LRSLHETPDY----TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHS 645
+ ++E RW + E L ++ K+D+WSFG+LMWE++TLG+TPY
Sbjct: 632 ARDVITSKIYERKSEGKLPIRWMATESLYDNIFSVKSDIWSFGILMWEIVTLGSTPYPGI 691
Query: 646 GNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLV 692
DV ++ G R +P + EL+ + CW DP ERP F+ ++
Sbjct: 692 SAADVMRKVRDGYRLEKPEHCRRELYNIMYYCWSHDPQERPLFAEII 738
>UniRef50_UPI0000DB7F8D Cluster: PREDICTED: similar to Cad96Ca
CG10244-PA; n=3; Endopterygota|Rep: PREDICTED: similar
to Cad96Ca CG10244-PA - Apis mellifera
Length = 657
Score = 143 bits (346), Expect = 2e-32
Identities = 82/280 (29%), Positives = 135/280 (48%), Gaps = 12/280 (4%)
Query: 422 NLKRKLWNIPRNLIETDISCVVGVGTYXXXXXXXXXXXXXXXXXXXXXIADRELEKTEKK 481
N + W PR+ ++ + ++G G + + + TE++
Sbjct: 346 NKQEDKWEFPRHRLK--VFNILGEGCFGQVWKCEALDIDGKSGAIIVAVKTLKENATERE 403
Query: 482 QM--LQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNK 539
++ QEL ++ H NV+ L+G C + V+LE + K L R+ +N+
Sbjct: 404 RLDLAQELRVMKNLDPHPNVVRLLGCCTEREPMFVILEYVSGG-KLQSFLRASREERNHG 462
Query: 540 FCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSH---LR 596
+T + Q+A+GMEYL ++ I+H+ L RN++I EN K+A FG +
Sbjct: 463 GPGLTSRDLTGFVYQIAKGMEYLASKGIIHRDLAARNILIDENRACKVADFGFARDVAAN 522
Query: 597 SLHETPDY----TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGS 652
++E RW + E L ++ K+D+WSFGVL+WE++TLG+TPY +V
Sbjct: 523 QIYERKSEGRLPIRWMAPESLYDNIFSVKSDIWSFGVLIWEIVTLGSTPYPGLAAAEVMR 582
Query: 653 RILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLV 692
RI G R +P + EL+ + CW DP RP+F LV
Sbjct: 583 RIKEGYRLDRPEHCKRELYNIMYYCWDKDPACRPSFGELV 622
>UniRef50_Q64GK4 Cluster: C-Met receptor tyrosine kinase; n=9;
Clupeocephala|Rep: C-Met receptor tyrosine kinase - Danio
rerio (Zebrafish) (Brachydanio rerio)
Length = 1382
Score = 141 bits (342), Expect = 5e-32
Identities = 90/256 (35%), Positives = 140/256 (54%), Gaps = 24/256 (9%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGIC-ETNTTLLVVLEDIKK-TLKEMLLLSRQRDIQ 536
E Q L+E +++K H NV+SL+GIC + + LVVL +K L+ + RD
Sbjct: 1121 EVSQFLKE-GIIVKDFSHPNVLSLLGICLPSEGSPLVVLPYMKHGDLRNFI-----RDES 1174
Query: 537 NNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSH-- 594
+N T ++ +QVA+GMEYL ++K VH+ L RN ++ E+ TVK+A GL+
Sbjct: 1175 HNP----TVKDLMGFGLQVAKGMEYLASKKFVHRDLAARNCMLDESYTVKVADVGLARDV 1230
Query: 595 -------LRSLHETPDYTRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGN 647
+ + H +W + E L+ ++ K+DVWSFGVL+WE++T GA PYS +
Sbjct: 1231 YDKEYYSVHNKHGVKLPVKWMALESLQTHKFTTKSDVWSFGVLLWELMTRGAPPYSDVNS 1290
Query: 648 KDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTP-FSEAPGTRN 706
D+ +L+G R QP + D L+ V ++CW P+ RPTF LV ++ FS G
Sbjct: 1291 FDITVFLLQGRRLLQPEFCPDALYNVMIECWHPKPERRPTFLELVSRISAIFSSFSGEHY 1350
Query: 707 --LSFTHYNGFEFEPH 720
L+ T+ N + P+
Sbjct: 1351 ILLNTTYVNIDKMTPY 1366
>UniRef50_P23049 Cluster: Tyrosine-protein kinase transforming
protein SEA; n=6; root|Rep: Tyrosine-protein kinase
transforming protein SEA - Avian erythroblastosis virus
(strain S13)
Length = 370
Score = 141 bits (342), Expect = 5e-32
Identities = 87/227 (38%), Positives = 124/227 (54%), Gaps = 19/227 (8%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTL-LVVLEDIKKTLKEMLLLSRQRDIQN 537
E ++ L+E +L+K H V+SL+G+C L LVVL ++ + +++R
Sbjct: 102 EVEEFLRE-GILMKGFHHPQVLSLLGVCLPRHGLPLVVLPYMRHGDLRHFVRAQER---- 156
Query: 538 NKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSH--- 594
S T +++ +QVA GMEYL +K VH+ L RN ++ E TVK+A FGL+
Sbjct: 157 ----SPTVKELIGFGLQVALGMEYLAQKKFVHRDLAARNCMLDETLTVKVADFGLARDVF 212
Query: 595 ------LRSLHETPDYTRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNK 648
+R RW + E L+ ++ K+DVWSFGVLMWE+LT GA+PY
Sbjct: 213 GKEYYSIRQHRHAKLPVRWMALESLQTQKFTTKSDVWSFGVLMWELLTRGASPYPEVDPY 272
Query: 649 DVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIEL 695
D+ +LRG R QP D L+ V L CW P+ERP+FS LV EL
Sbjct: 273 DMARYLLRGRRLPQPQPCPDTLYGVMLSCWAPTPEERPSFSGLVCEL 319
>UniRef50_P11362 Cluster: Basic fibroblast growth factor receptor 1
precursor; n=310; Euteleostomi|Rep: Basic fibroblast
growth factor receptor 1 precursor - Homo sapiens
(Human)
Length = 822
Score = 141 bits (342), Expect = 5e-32
Identities = 78/238 (32%), Positives = 130/238 (54%), Gaps = 20/238 (8%)
Query: 476 EKTEK--KQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKK-TLKEMLLLSRQ 532
+ TEK ++ E++++ +H+N+I+L+G C + L V++E K L+E L R
Sbjct: 519 DATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRP 578
Query: 533 RDIQ------NNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVK 586
++ +N ++ ++ QVARGMEYL ++K +H+ L RN++++E+ +K
Sbjct: 579 PGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMK 638
Query: 587 IAGFGLSHLRSLHETPDY---------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTL 637
IA FGL+ R +H Y +W + E L Y ++DVWSFGVL+WE+ TL
Sbjct: 639 IADFGLA--RDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTL 696
Query: 638 GATPYSHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIEL 695
G +PY +++ + G R +PS +EL+ + CW P +RPTF LV +L
Sbjct: 697 GGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 754
>UniRef50_Q3TJ05 Cluster: 14 days pregnant adult female placenta
cDNA, RIKEN full-length enriched library,
clone:I530025O09 product:fibroblast growth factor
receptor 1, full insert sequence; n=18; Eumetazoa|Rep:
14 days pregnant adult female placenta cDNA, RIKEN
full-length enriched library, clone:I530025O09
product:fibroblast growth factor receptor 1, full insert
sequence - Mus musculus (Mouse)
Length = 386
Score = 140 bits (340), Expect = 9e-32
Identities = 78/238 (32%), Positives = 129/238 (54%), Gaps = 20/238 (8%)
Query: 476 EKTEK--KQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKK-TLKEMLLLSRQ 532
+ TEK ++ E++++ +H+N+I+L+G C + L V++E K L+E L R
Sbjct: 83 DATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRP 142
Query: 533 RDIQ------NNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVK 586
++ +N ++ ++ QVARGMEYL ++K +H+ L RN +++E+ +K
Sbjct: 143 PGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNALVTEDNVMK 202
Query: 587 IAGFGLSHLRSLHETPDY---------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTL 637
IA FGL+ R +H Y +W + E L Y ++DVWSFGVL+WE+ TL
Sbjct: 203 IADFGLA--RDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTL 260
Query: 638 GATPYSHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIEL 695
G +PY +++ + G R +PS +EL+ + CW P +RPTF LV +L
Sbjct: 261 GGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 318
>UniRef50_P17948 Cluster: Vascular endothelial growth factor receptor
1 precursor; n=48; cellular organisms|Rep: Vascular
endothelial growth factor receptor 1 precursor - Homo
sapiens (Human)
Length = 1338
Score = 140 bits (338), Expect = 2e-31
Identities = 70/169 (41%), Positives = 101/169 (59%), Gaps = 12/169 (7%)
Query: 543 ITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSLHETP 602
IT ++ QVARGME+L +RK +H+ L RN+++SEN VKI FGL+ R +++ P
Sbjct: 994 ITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLA--RDIYKNP 1051
Query: 603 DYTR---------WTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPY-SHSGNKDVGS 652
DY R W + E + Y+ K+DVWS+GVL+WE+ +LG +PY ++D S
Sbjct: 1052 DYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCS 1111
Query: 653 RILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEA 701
R+ GMR P Y E++Q+ L CW DP ERP F+ LV +L +A
Sbjct: 1112 RLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGDLLQA 1160
>UniRef50_Q4SII9 Cluster: Chromosome 5 SCAF14581, whole genome
shotgun sequence; n=2; Tetraodontidae|Rep: Chromosome 5
SCAF14581, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 921
Score = 139 bits (336), Expect = 3e-31
Identities = 75/220 (34%), Positives = 115/220 (52%), Gaps = 20/220 (9%)
Query: 487 LDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQ-RDIQNNKFCSITE 545
L ++K +H NV+ LIG+C + +V+E I+ + + L Q RD++ + E
Sbjct: 707 LSRILKQYDHPNVVKLIGVCTQKQPIYIVMELIQGSGDFLTFLRNQGRDLKPKALVKMAE 766
Query: 546 NKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRS-------- 597
N VA GM YL ++K +H+ L RN +++EN +VKI+ FG+S
Sbjct: 767 N--------VASGMAYLESKKCIHRDLAARNCLVAENNSVKISDFGMSRQDDDGVYLAEG 818
Query: 598 -LHETPDYTRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRILR 656
L + P +WT+ E L RY ++DVWSFG+L+WE +LG TPY N+ + +
Sbjct: 819 GLRQIP--IKWTAPEALNYGRYTTQSDVWSFGILLWETFSLGLTPYMSMSNQQTRDEVEK 876
Query: 657 GMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELT 696
G R P E+ ++ CWQ DP RP+F L EL+
Sbjct: 877 GYRMPAPHACPVEIARIMNNCWQYDPQNRPSFKKLRAELS 916
>UniRef50_A7RGV3 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 250
Score = 139 bits (336), Expect = 3e-31
Identities = 79/227 (34%), Positives = 132/227 (58%), Gaps = 22/227 (9%)
Query: 483 MLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKK-TLKEMLLLSRQRDIQNNKFC 541
M+ E+D+L H NV+SL+G C + L VV+E ++ L+++LL SR + NK+
Sbjct: 1 MMTEMDILKHVGRHPNVVSLVGACTLDEPLFVVIEFVEGGDLRDLLLKSR---MSRNKWA 57
Query: 542 S---------ITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGL 592
S + E ++L + + VARGM +L ++ +H+ L RN+++ K+A FGL
Sbjct: 58 SSSYENLRSRLNERQLLFLALGVARGMAHLEEKQCIHRDLAARNVLVGLGLVAKVADFGL 117
Query: 593 S-HLRS--LHETPDYTR----WTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHS 645
+ H+ + L+ T+ W + E LR Y K+DVWSFGV++WE+ TLG TPY +
Sbjct: 118 ARHVTTDGLYIVSAQTKLPWKWMAPESLRGL-YTTKSDVWSFGVVLWEIATLGETPYPNE 176
Query: 646 GN-KDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSL 691
+ + ++ G R S+P Y +E++++ L+CWQ+DP RP+F +
Sbjct: 177 VSIMKLLQHLIDGHRMSKPPYCDEEIYKLMLECWQLDPATRPSFKEI 223
>UniRef50_A3EXK6 Cluster: Fibroblast growth factor receptor c; n=2;
Nematostella vectensis|Rep: Fibroblast growth factor
receptor c - Nematostella vectensis
Length = 297
Score = 139 bits (336), Expect = 3e-31
Identities = 76/235 (32%), Positives = 133/235 (56%), Gaps = 22/235 (9%)
Query: 481 KQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNKF 540
+ ++QEL+L+ H N+++LIG C + L++++E LL + D+Q+ +
Sbjct: 60 RDLVQELELMHSVGHHRNLLNLIGACTDSEKLMIIVEFANDGCLLDLLHQARGDLQSPRI 119
Query: 541 CS----------ITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGF 590
+ + + L+I + VA+GM+YL +++ VH+ L RN++I++ G K+A F
Sbjct: 120 YQNIEPRHSEVVLGQTRRLEIALDVAQGMDYLASKRCVHRDLAARNVLIAD-GVAKVADF 178
Query: 591 GLSHLRSLHETPDY---------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATP 641
GLS R+++ET +Y TRW S E L ++ ++DVWS+GVL+WE+ T G TP
Sbjct: 179 GLS--RNIYETGEYEKTTRGKLPTRWMSLESLETRKFTLESDVWSYGVLLWEIETRGLTP 236
Query: 642 YSHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELT 696
+ +++ +R +G R +P L+++ +CW P RPTFS +V +LT
Sbjct: 237 NAGLNYREMIARYRKGYRLERPPDCDQGLYEIMRRCWLAIPKSRPTFSDIVEQLT 291
>UniRef50_Q04912 Cluster: Macrophage-stimulating protein receptor
precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CD136
antigen) (CDw136) [Contains: Macrophage- stimulating
protein receptor alpha chain; Macrophage-stimulating
protein receptor beta chain]; n=15; Eutheria|Rep:
Macrophage-stimulating protein receptor precursor (EC
2.7.10.1) (MSP receptor) (p185-Ron) (CD136 antigen)
(CDw136) [Contains: Macrophage- stimulating protein
receptor alpha chain; Macrophage-stimulating protein
receptor beta chain] - Homo sapiens (Human)
Length = 1400
Score = 139 bits (336), Expect = 3e-31
Identities = 96/275 (34%), Positives = 132/275 (48%), Gaps = 17/275 (6%)
Query: 430 IPRNLIETDISCVVGVGTYXXXXXXXXXXXXXXXXXXXXXIADRELEKTEKKQMLQELDL 489
IP + T V+G G + R E + + L+E L
Sbjct: 1075 IPHERVVTHSDRVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLRE-GL 1133
Query: 490 LIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNKFCSITENKVL 549
L++ H NV++LIGI L VL + LL R Q N T ++
Sbjct: 1134 LMRGLNHPNVLALIGIMLPPEGLPHVLLPY---MCHGDLLQFIRSPQRNP----TVKDLI 1186
Query: 550 QICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHL---RSLHETPDY-- 604
+QVARGMEYL +K VH+ L RN ++ E+ TVK+A FGL+ R + +
Sbjct: 1187 SFGLQVARGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRH 1246
Query: 605 ----TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRILRGMRP 660
+W + E L+ R+ K+DVWSFGVL+WE+LT GA PY H D+ + +G R
Sbjct: 1247 ARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRL 1306
Query: 661 SQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIEL 695
QP Y D L+QV QCW+ DP RPTF LV E+
Sbjct: 1307 PQPEYCPDSLYQVMQQCWEADPAVRPTFRVLVGEV 1341
>UniRef50_Q8MY85 Cluster: Fibroblast growth factor receptor 2
precursor; n=3; Dugesia japonica|Rep: Fibroblast growth
factor receptor 2 precursor - Dugesia japonica
(Planarian)
Length = 887
Score = 139 bits (336), Expect = 3e-31
Identities = 75/226 (33%), Positives = 127/226 (56%), Gaps = 12/226 (5%)
Query: 483 MLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKK-TLKEMLLLSRQR----DIQN 537
++QEL+++ H ++ISL G C N +V+E K L++ L R + +IQN
Sbjct: 633 LIQELEMMKIIGRHRHIISLYGACIDNGHPYMVIELAKHGNLRDFLRAQRSQSKVGEIQN 692
Query: 538 NK--FCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHL 595
+ +T L+ +++A GMEYL +RKI+H+ L RN+++ + +KIA FGL+ +
Sbjct: 693 SGGLVTRLTVTDFLRFSIEIAEGMEYLSSRKIIHRDLAARNVLVDQYVEMKIADFGLTRI 752
Query: 596 --RSLHETPDYT---RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDV 650
+T D +W + E L Y K+DVWS+G+++WE+ T+G TPY + +
Sbjct: 753 VENYYRKTTDGRLPIKWMAPECLLDRVYTVKSDVWSYGIVLWEIFTMGQTPYPTIQSDGM 812
Query: 651 GSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELT 696
+ G+R +P+ DE++++ L W DP ER TFS ++ +LT
Sbjct: 813 HQALRNGIRNEKPALASDEMYRLMLTIWNDDPLERHTFSEIIDKLT 858
>UniRef50_P35590 Cluster: Tyrosine-protein kinase receptor Tie-1
precursor; n=37; Deuterostomia|Rep: Tyrosine-protein
kinase receptor Tie-1 precursor - Homo sapiens (Human)
Length = 1138
Score = 138 bits (335), Expect = 4e-31
Identities = 73/236 (30%), Positives = 125/236 (52%), Gaps = 11/236 (4%)
Query: 477 KTEKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKK-TLKEMLLLSRQRDI 535
+ + + EL++L K H N+I+L+G C+ L + +E L + L SR +
Sbjct: 878 ENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLET 937
Query: 536 ------QNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAG 589
++ +++ ++L+ A GM+YL ++ +H+ L RN+++ EN KIA
Sbjct: 938 DPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIAD 997
Query: 590 FGLSHLRSLHETPDY----TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHS 645
FGLS ++ RW + E L + Y K+DVWSFGVL+WE+++LG TPY
Sbjct: 998 FGLSRGEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGM 1057
Query: 646 GNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEA 701
++ ++ +G R QP DE++++ QCW+ P ERP F+ + ++L EA
Sbjct: 1058 TCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLEA 1113
>UniRef50_UPI0000D577C3 Cluster: PREDICTED: similar to CG8874-PB,
isoform B; n=3; Endopterygota|Rep: PREDICTED: similar to
CG8874-PB, isoform B - Tribolium castaneum
Length = 801
Score = 138 bits (334), Expect = 5e-31
Identities = 69/222 (31%), Positives = 118/222 (53%), Gaps = 15/222 (6%)
Query: 475 LEKTEKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRD 534
L + KK+ LQE ++K +H N++ LIGIC +++V+E + +L R++
Sbjct: 574 LPEDHKKKFLQE-GRILKQYDHPNIVKLIGICVQKQPIMIVMELVPGG--SLLTFLRKKT 630
Query: 535 IQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSH 594
++T+ +++++C+ A GM YL ++ +H+ L RN ++ N VKI+ FG+S
Sbjct: 631 -------ALTDAQLMKMCLDAAAGMRYLESKNCIHRDLAARNCLVGYNNVVKISDFGMSR 683
Query: 595 LRSLHETPDYTR-----WTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKD 649
+ D + WT+ E L +Y DVWS+G+L WE+ + G TPYS N
Sbjct: 684 EEEEYIVSDGMKQIPIKWTAPEALNFGKYTSLCDVWSYGILCWEIFSRGGTPYSGLSNSK 743
Query: 650 VGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSL 691
+I G R P DE++++ L+CW+ P+ RP F +
Sbjct: 744 AREKIDAGYRMPAPDNTPDEMYRLMLRCWEYKPENRPNFEQI 785
>UniRef50_Q4SR43 Cluster: Chromosome 11 SCAF14528, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 11 SCAF14528, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 1373
Score = 138 bits (334), Expect = 5e-31
Identities = 82/224 (36%), Positives = 127/224 (56%), Gaps = 19/224 (8%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTL-LVVLEDIKKTLKEMLLLSRQRDIQN 537
E +Q L+E +++K H NV+SL+GI L LVVL +K + +R
Sbjct: 1133 EVEQFLKE-GIIMKGFHHCNVLSLLGILLPQEGLPLVVLPYMKHGDLRHFIRCEKR---- 1187
Query: 538 NKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSH--- 594
+ T ++ +QVA GMEYL +K VH+ L RN ++ E+ TVK+A FG++
Sbjct: 1188 ----NPTVKDLIGFGLQVATGMEYLAQKKFVHRDLAARNCMLDESYTVKVADFGMARDVL 1243
Query: 595 ------LRSLHETPDYTRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNK 648
+++ + +W + E L+ ++ PK+DVWSFGVLMWE+LT GA+PY
Sbjct: 1244 DKEYYSVQNHRKAKLPVKWMAIESLQTQKFTPKSDVWSFGVLMWEMLTRGASPYPDVDPY 1303
Query: 649 DVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLV 692
D+ +LRG R QP + D L+++ LQCW +P+ RP+F++LV
Sbjct: 1304 DITHYLLRGRRLPQPQFCPDPLYRIMLQCWDPEPELRPSFATLV 1347
>UniRef50_Q6DTW4 Cluster: Tyrosine kinase receptor ron; n=6;
Eumetazoa|Rep: Tyrosine kinase receptor ron - Canis
familiaris (Dog)
Length = 998
Score = 138 bits (334), Expect = 5e-31
Identities = 95/275 (34%), Positives = 133/275 (48%), Gaps = 17/275 (6%)
Query: 430 IPRNLIETDISCVVGVGTYXXXXXXXXXXXXXXXXXXXXXIADRELEKTEKKQMLQELDL 489
IP + T V+G G + R E E + L+E L
Sbjct: 673 IPHEQVVTHSDRVIGKGHFGVVYHGEYIDEDQNRIHCAVKSLSRITEVQEAEAFLRE-GL 731
Query: 490 LIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNKFCSITENKVL 549
L++ H NV++LIGI L VL ++ LL R Q N T ++
Sbjct: 732 LMRGLHHPNVLALIGIVLPPEGLPRVLLPY---MRHGDLLRFIRSPQRNP----TVKDLI 784
Query: 550 QICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSH---------LRSLHE 600
+QVARGMEYL +K VH+ L RN ++ E+ TVK+A FGL+ +R
Sbjct: 785 SFGLQVARGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDKEYYSVRQHRH 844
Query: 601 TPDYTRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRILRGMRP 660
+W + E L+ R+ K+DVWSFGVL+WE+LT GA PY H D+ + +G R
Sbjct: 845 ARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYPHIDPFDLIQFLAQGRRL 904
Query: 661 SQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIEL 695
QP Y + L+ V +CW VDP RPTF++LV E+
Sbjct: 905 PQPEYCPNSLYMVMQRCWAVDPAVRPTFTALVEEV 939
>UniRef50_UPI0000E49FB6 Cluster: PREDICTED: similar to RE05926p,
partial; n=2; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to RE05926p, partial -
Strongylocentrotus purpuratus
Length = 859
Score = 138 bits (333), Expect = 6e-31
Identities = 80/261 (30%), Positives = 136/261 (52%), Gaps = 20/261 (7%)
Query: 477 KTEKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLE-----DIKKTLKEMLL-LS 530
+ +K + +EL L + H N+++++G C + +++E +++ L+++ S
Sbjct: 355 ENDKSDLSKELSLYMYLDPHPNIVNILGCCTDSDPWYIIMEYLPNNNLQGYLRQIRTGES 414
Query: 531 RQRDIQN-NKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAG 589
D +N K I N +L VQ+ARGMEYL +R+ +H+ L RN+++ E K++
Sbjct: 415 MTADYRNVKKQKDIPPNDLLTFGVQIARGMEYLASRQCIHRDLAARNILLGEGYVCKVSD 474
Query: 590 FGLSHLRSLHETPDY---------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGAT 640
FGL+ R L + Y RW S E L Y ++DVWSF +L+WE++TLG+
Sbjct: 475 FGLA--RDLEDGQTYEMKSQGRVPVRWMSPESLLHNTYTSQSDVWSFAILIWEIVTLGSH 532
Query: 641 PYSHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIEL-TPFS 699
PY +K V I G R +P + +++ + +CW + +ERPTFS + + L +
Sbjct: 533 PYPGMSSKQVVKEISAGYRLPKPEHCSQDIYNLMKECWAYEAEERPTFSQVKVRLENMLA 592
Query: 700 EAPGTRNLS-FTHYNGFEFEP 719
+A G +S F N EP
Sbjct: 593 DAQGYLVMSDFNDDNYLYLEP 613
>UniRef50_O76978 Cluster: Tyrosine kinase; n=1; Sycon raphanus|Rep:
Tyrosine kinase - Sycon raphanus
Length = 879
Score = 138 bits (333), Expect = 6e-31
Identities = 72/230 (31%), Positives = 122/230 (53%), Gaps = 19/230 (8%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNN 538
+K++ LQE ++L K H N++ LIG+C L +++E + LS R +
Sbjct: 658 DKQKFLQEAEIL-KQYRHPNIVELIGVCAEKEPLYIIME----LMAGGNFLSFLRGPEGK 712
Query: 539 KFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRS- 597
+ + N + ++CV+ A GM +L R +H+ L RN ++ +N +KI+ FG+S
Sbjct: 713 R---LKVNNLTEMCVEAAAGMVFLEQRNCIHRDLAARNCLVGDNNVLKISDFGMSREEDD 769
Query: 598 --------LHETPDYTRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKD 649
L + P +WTS E L RY ++DVWS+G+L+WE T G+ PY N++
Sbjct: 770 GIYTVSSGLKQIP--IKWTSPEALNYGRYTTQSDVWSYGILLWETYTYGSGPYPGMNNRE 827
Query: 650 VGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFS 699
RI R +P ++++ L CW+ DPD+RP+F+ + +L F+
Sbjct: 828 TRERIESNYRMPRPELCPHPVYKLMLSCWEYDPDKRPSFAEIYDKLYSFN 877
>UniRef50_P22182 Cluster: Fibroblast growth factor receptor 1
precursor; n=33; Euteleostomi|Rep: Fibroblast growth
factor receptor 1 precursor - Xenopus laevis (African
clawed frog)
Length = 812
Score = 138 bits (333), Expect = 6e-31
Identities = 77/238 (32%), Positives = 130/238 (54%), Gaps = 18/238 (7%)
Query: 474 ELEKTEKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKK-TLKEMLLLSRQ 532
+ + + ++ E++++ +H+N+I+L+G C + L V++E K L+E L R
Sbjct: 513 DASEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYTSKGNLREYLRARRP 572
Query: 533 RDIQN--NKFC---SITENKVLQICV-QVARGMEYLHTRKIVHKKLCCRNMIISENGTVK 586
++ N C + K L C QVARGM+YL ++K +H+ L RN++++E+ +K
Sbjct: 573 PAMEYCYNPTCVPDQLLSFKDLVSCAYQVARGMDYLASKKCIHRDLAARNVLVTEDNIMK 632
Query: 587 IAGFGLSHLRSLHETPDY---------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTL 637
IA FGL+ R +H Y +W + E L Y ++DVWSFGVL+WE+ TL
Sbjct: 633 IADFGLA--RDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTL 690
Query: 638 GATPYSHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIEL 695
G +PY +++ + G R +P+ +EL+ + CW P +RPTF+ LV +L
Sbjct: 691 GGSPYPGVPMEELFKLLKEGHRMDKPTNCTNELYMMMKDCWHAMPSQRPTFNQLVEDL 748
>UniRef50_Q9YGM5 Cluster: Plasminogen related growth factor receptor
2; n=11; Clupeocephala|Rep: Plasminogen related growth
factor receptor 2 - Fugu rubripes (Japanese pufferfish)
(Takifugu rubripes)
Length = 1375
Score = 137 bits (332), Expect = 9e-31
Identities = 84/276 (30%), Positives = 141/276 (51%), Gaps = 19/276 (6%)
Query: 430 IPRNLIETDISCVVGVGTYXXXXXXXXXXXXXXXXXXXXXIADRELEKTEKKQMLQELDL 489
IP +++ + V+G G + +R + + L+E L
Sbjct: 1058 IPADMLRIEDRQVIGKGHFGTVYHGYLIDSNKQETHCAVKSLNRITDLKDVDHFLRE-GL 1116
Query: 490 LIKTSEHENVISLIGICETNTTL-LVVLEDIKKTLKEMLLLSRQRDIQNNKFCSITENKV 548
++K +H N++SL+GI L LVVL +K + S +R+ T +
Sbjct: 1117 IMKGFDHPNILSLLGIMLPKEGLPLVVLPYMKHGDVRHFIRSEKRNP--------TVKDL 1168
Query: 549 LQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLS---HLRSLHETPDY- 604
+ +QVA+GMEYL +K VH+ L RN ++ E TVK+A FG++ + + + D+
Sbjct: 1169 IGFGLQVAKGMEYLAQKKFVHRDLAARNCMLDETYTVKVADFGMARDIYDKEYYSIQDHK 1228
Query: 605 -----TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRILRGMR 659
+W + E L+ ++ K+DVWS+G+LMWE+LT GA+PY D+ + +L+G R
Sbjct: 1229 QVKLPVKWMAIESLQTQKFTSKSDVWSYGILMWELLTRGASPYPDVDPYDITNYLLKGRR 1288
Query: 660 PSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIEL 695
QP + + L+ + L CW +PD RP+FSSL ++
Sbjct: 1289 LPQPQFCPNTLYSIMLSCWDPEPDFRPSFSSLASDV 1324
>UniRef50_Q8IXC7 Cluster: Isoform of FGFR2; n=23; Euteleostomi|Rep:
Isoform of FGFR2 - Homo sapiens (Human)
Length = 709
Score = 137 bits (332), Expect = 9e-31
Identities = 79/238 (33%), Positives = 128/238 (53%), Gaps = 20/238 (8%)
Query: 476 EKTEK--KQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKK-TLKEMLLLSR- 531
+ TEK ++ E++++ +H+N+I+L+G C + L V++E K L+E L R
Sbjct: 410 DATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRP 469
Query: 532 -----QRDIQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVK 586
DI +T ++ Q+ARGMEYL ++K +H+ L RN++++EN +K
Sbjct: 470 PGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMK 529
Query: 587 IAGFGLSHLRSLHETPDY---------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTL 637
IA FGL+ R ++ Y +W + E L Y ++DVWSFGVLMWE+ TL
Sbjct: 530 IADFGLA--RDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTL 587
Query: 638 GATPYSHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIEL 695
G +PY +++ + G R +P+ +EL+ + CW P +RPTF LV +L
Sbjct: 588 GGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 645
>UniRef50_A7RHT9 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 295
Score = 137 bits (331), Expect = 1e-30
Identities = 85/280 (30%), Positives = 134/280 (47%), Gaps = 23/280 (8%)
Query: 428 WNIPRNLIETDISCVVGVGTYXXXXXXXXXXXXXXXXXX--XXXIADRELEKTEKKQMLQ 485
W PR+ ++T + V+G G + I T ++ ++
Sbjct: 2 WEFPRDRVKTSV--VLGSGAFGVVMKADAQGIKGCVGSLPVAVKIVKENDSDTARRDLMA 59
Query: 486 ELDLLIKTSEHENVISLIGICETNTTLLVVLE-----DIKKTLKEMLLLSRQ--RDIQNN 538
ELDLL H NVI L+G C L+V++E D++ L+ + + I
Sbjct: 60 ELDLLKLIDPHPNVIGLLGCCTRGDPLMVIVEFCQYGDLQSYLRHCRGIEDKYYEQIYMV 119
Query: 539 KFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSL 598
+T +L +Q ARGM +L + K+VH+ L RN++I E K++ FG + R +
Sbjct: 120 PEKKLTAKDLLSFGIQAARGMAHLASMKVVHRDLAARNILIDEKSVCKVSDFGFA--RDI 177
Query: 599 HETPDYTR----------WTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNK 648
+ YTR W + E L K+DVWS+GVL+WE++TLGA+PY ++
Sbjct: 178 YVEDHYTRKTQGGRFPIKWMAIESLLDGVSTTKSDVWSYGVLLWEIVTLGASPYPGMNSQ 237
Query: 649 DVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTF 688
+V + + G R +P + DEL+ V L CWQ+ RPTF
Sbjct: 238 EVINFLQDGYRMDKPKHCLDELYAVMLDCWQLSAQRRPTF 277
>UniRef50_A3EXK5 Cluster: Fibroblast growth factor receptor b; n=1;
Nematostella vectensis|Rep: Fibroblast growth factor
receptor b - Nematostella vectensis
Length = 591
Score = 137 bits (331), Expect = 1e-30
Identities = 74/232 (31%), Positives = 124/232 (53%), Gaps = 17/232 (7%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKK-TLKEMLLLSRQRDIQN 537
E ++ E++++ +H N+I+LIG C L VV+E + L++ L R
Sbjct: 318 ELADLVSEMEVMKTIGQHVNIINLIGACTQKGPLFVVVEYASQGNLRQFLRARRPIPEYA 377
Query: 538 NKFCSITENKV-----LQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGL 592
N K+ + QVARGMEYL ++K +H+ L RN+++S+N +KIA FGL
Sbjct: 378 NPLTEPPREKLKLVDLVSFSYQVARGMEYLESKKCIHRDLAARNVLVSDNHVIKIADFGL 437
Query: 593 SHLRSLHETPDY---------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYS 643
+ R +H+ Y +W + E L Y ++DVW++G+LMWE++T G +PY
Sbjct: 438 A--RDIHDIDYYRKTTDGRLPVKWMALEALFDRVYTAQSDVWAYGILMWEIVTFGGSPYP 495
Query: 644 HSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIEL 695
+ + G R QP D+++ + L+CW +P++RPTF+ +V E+
Sbjct: 496 GIPLWKLFELLKEGYRMEQPVNCQDDVYALMLRCWHENPNQRPTFAEIVKEM 547
>UniRef50_A3EXK4 Cluster: Fibroblast growth factor receptor a; n=1;
Nematostella vectensis|Rep: Fibroblast growth factor
receptor a - Nematostella vectensis
Length = 441
Score = 137 bits (331), Expect = 1e-30
Identities = 86/306 (28%), Positives = 147/306 (48%), Gaps = 19/306 (6%)
Query: 406 NSGFILEDEERVDYYGNLKRKLWNIPRNLIETDISCVVGVGTYXXXXXXXXXXXXXXXXX 465
+S ++ +E +D+Y + W I R+ I I +G G +
Sbjct: 90 DSSSVITEESFLDFYELPIDEDWEIDRSQIT--IKEQLGEGAFGLVMKAEALGLTDMPYR 147
Query: 466 XXXXIADRELEKTEKK--QMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKK-T 522
+ + + TE + +L E+D + H+N+I+LIG C N L VV+E
Sbjct: 148 HTVAVKMLKADATENELADLLSEMDTMKNIGSHKNIINLIGACTQNGPLYVVVEFAPHGN 207
Query: 523 LKEMLLLSRQRDIQNNKFCSITENK-------VLQICVQVARGMEYLHTRKIVHKKLCCR 575
L++ L R D ++ S T ++ + Q+ARGMEYL +K +H+ L R
Sbjct: 208 LRQFLRERRPSDYHRSRSDSSTHSQPSLIVRDFISFAFQIARGMEYLSFKKCIHRDLAAR 267
Query: 576 NMIISENGTVKIAGFGLS-HLRSLHETPDYT------RWTSHEMLRQTRYNPKADVWSFG 628
N+++ E+ +KIA FGL+ ++R + T +W + E L Y ++DVW+FG
Sbjct: 268 NILVGEDYVMKIADFGLARNVRDMDYYRKATDGRLPIKWLAIEALFDRVYTTQSDVWTFG 327
Query: 629 VLMWEVLTLGATPYSHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTF 688
+L+WE+ TLG +PY + + + G R P D+++ + L CW +P+ RP+F
Sbjct: 328 ILLWEIFTLGGSPYPGIPVEKLFELLKSGYRMQMPQKCPDKMYDIMLSCWNENPNARPSF 387
Query: 689 SSLVIE 694
+ L E
Sbjct: 388 TELRAE 393
>UniRef50_P08581 Cluster: Hepatocyte growth factor receptor precursor;
n=81; Tetrapoda|Rep: Hepatocyte growth factor receptor
precursor - Homo sapiens (Human)
Length = 1390
Score = 136 bits (330), Expect = 1e-30
Identities = 81/230 (35%), Positives = 128/230 (55%), Gaps = 23/230 (10%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGIC-ETNTTLLVVLEDIKKTLKEMLLLSRQRDIQN 537
E Q L E +++K H NV+SL+GIC + + LVVL +K R+
Sbjct: 1120 EVSQFLTE-GIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKH--------GDLRNFIR 1170
Query: 538 NKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRS 597
N+ + T ++ +QVA+GM+YL ++K VH+ L RN ++ E TVK+A FGL+ R
Sbjct: 1171 NETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLA--RD 1228
Query: 598 LHETPDYT-----------RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSG 646
+++ Y+ +W + E L+ ++ K+DVWSFGV++WE++T GA PY
Sbjct: 1229 MYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVVLWELMTRGAPPYPDVN 1288
Query: 647 NKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELT 696
D+ +L+G R QP Y D L++V L+CW + RP+FS LV ++
Sbjct: 1289 TFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRIS 1338
>UniRef50_UPI0000D55449 Cluster: PREDICTED: similar to CG7223-PA,
isoform A; n=1; Tribolium castaneum|Rep: PREDICTED:
similar to CG7223-PA, isoform A - Tribolium castaneum
Length = 861
Score = 136 bits (329), Expect = 2e-30
Identities = 76/233 (32%), Positives = 130/233 (55%), Gaps = 16/233 (6%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKK-TLKEMLLLSRQRD--- 534
E ++ E++++ +H N+I+L+G C L VV+E L++ L R
Sbjct: 577 EMMDLVSEMEMMKMIGKHNNIINLLGCCTQGGPLYVVVEYAPYGNLRDFLRQHRPSSGYE 636
Query: 535 ----IQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGF 590
++ + ++T+ ++ QVARGMEYL +R+ +H+ L RN+++S++ +KIA F
Sbjct: 637 PAIGLEEKEKKTLTQKDLVSFAYQVARGMEYLASRRCIHRDLAARNVLVSDDYFLKIADF 696
Query: 591 GLS---HLRSLH-ETPD---YTRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYS 643
GL+ H + +T D +W + E L Y ++DVWS+G+L+WE++TLG TPY
Sbjct: 697 GLARDIHCNDYYRKTTDGRLPVKWMAPEALFHRVYTTQSDVWSYGILLWEIMTLGGTPYP 756
Query: 644 HSGNKDVGSRILR-GMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIEL 695
+ + ++LR G R +P E++ + +CW P+ERPTFS LV +L
Sbjct: 757 SVPSVEKLFQLLRNGHRMEKPPCCSLEIYMLMRECWSYKPNERPTFSQLVEDL 809
>UniRef50_Q179Z3 Cluster: Tyrosine-protein kinase; n=1; Aedes
aegypti|Rep: Tyrosine-protein kinase - Aedes aegypti
(Yellowfever mosquito)
Length = 343
Score = 136 bits (329), Expect = 2e-30
Identities = 72/229 (31%), Positives = 124/229 (54%), Gaps = 8/229 (3%)
Query: 477 KTEKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIK----KTLKEMLLLSRQ 532
K E ++ L E+ ++ + +H N+++L+G C L +++E I T+ L
Sbjct: 83 KPEFEEFLDEIAMMKQVGKHPNIVALLGCCTLKEPLTMIMEYIGCGDLVTMYTTLSGPND 142
Query: 533 RDIQNNKFCSITENKVLQ-ICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFG 591
+++ + ++K L Q+A GM++L + I H+ L RN++I E T+KI+ FG
Sbjct: 143 SSREHSALEYLLDHKELHDFARQIACGMKHLEEKNITHRDLAARNILIDEKKTLKISDFG 202
Query: 592 LSHLRSLHETPDYT---RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNK 648
LS T + RW S E +R Y+ K+DVW+FG+++WE+ TLG PY N
Sbjct: 203 LSRTGIYVNTRNKKVPLRWLSIEAMRDHLYSSKSDVWAFGIVLWEIGTLGGYPYPTVSNH 262
Query: 649 DVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTP 697
++ S + G R +P EL+++ L CW+ +PD+RP+F+ + L P
Sbjct: 263 ELLSFLHNGNRLDRPENCSAELYELMLHCWKAEPDDRPSFADIYKSLEP 311
>UniRef50_A7RZ71 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 624
Score = 136 bits (328), Expect = 3e-30
Identities = 88/314 (28%), Positives = 147/314 (46%), Gaps = 19/314 (6%)
Query: 398 SEPCVEIENSGFILEDEERVDYYGNLKRKLWNIPRNLIETDISCVVGVGTYXXXXXXXXX 457
S P + N +E +D+Y + W I R+ I I +G G +
Sbjct: 297 STPLIRYRNVTTSSIEESFLDFYELPIDEDWEIDRSQIT--IKEQLGEGAFGLVMKAEAL 354
Query: 458 XXXXXXXXXXXXIADRELEKTEKK--QMLQELDLLIKTSEHENVISLIGICETNTTLLVV 515
+ + + TE + +L E+D + H+N+I+LIG C N L VV
Sbjct: 355 GLTDMPYRHTVAVKMLKADATENELADLLSEMDTMKNIGSHKNIINLIGACTQNGPLYVV 414
Query: 516 LEDIKK-TLKEMLLLSRQRDIQNNKFCSITENK-------VLQICVQVARGMEYLHTRKI 567
+E L++ L R D ++ S T ++ + Q+ARGMEYL +K
Sbjct: 415 VEFAPHGNLRQFLRERRPSDYHRSRSDSSTHSQPSLIVRDFISFAFQIARGMEYLSFKKC 474
Query: 568 VHKKLCCRNMIISENGTVKIAGFGLS-HLRSLHETPDYT------RWTSHEMLRQTRYNP 620
+H+ L RN+++ E+ +KIA FGL+ ++R + T +W + E L Y
Sbjct: 475 IHRDLAARNILVGEDYVMKIADFGLARNVRDMDYYRKATDGRLPIKWLAIEALFDRVYTT 534
Query: 621 KADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQV 680
++DVW+FG+L+WE+ TLG +PY + + + G R P D+++ + L CW
Sbjct: 535 QSDVWTFGILLWEIFTLGGSPYPGIPVEKLFELLKSGYRMQMPQKCPDKMYDIMLSCWNE 594
Query: 681 DPDERPTFSSLVIE 694
+P+ RP+F+ L E
Sbjct: 595 NPNARPSFTELRAE 608
>UniRef50_Q0PDJ5 Cluster: Protein tyrosine kinase CSK; n=1; Monosiga
ovata|Rep: Protein tyrosine kinase CSK - Monosiga ovata
Length = 468
Score = 135 bits (327), Expect = 3e-30
Identities = 74/219 (33%), Positives = 119/219 (54%), Gaps = 12/219 (5%)
Query: 482 QMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNKFC 541
Q L E D + + H+N++ LIG+C + +++V E + K L SR R + N
Sbjct: 254 QFLLEADTMTRL-RHKNLVQLIGVCTQGSPIMIVSEFMGKGCLLDYLRSRGRAVIN---- 308
Query: 542 SITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSLHET 601
T+ L C + MEYL +K VH+ L RN+++S++G K+A FGL+ L T
Sbjct: 309 LATQ---LGFCRDICAAMEYLEEQKFVHRDLAARNILLSDDGVAKVADFGLAKDSQLGVT 365
Query: 602 PDYT---RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRILRGM 658
+WT+ E +R K+DVWSFGV++WE+ G PY G K+V +++G
Sbjct: 366 DIGKLPIKWTAPEAIRLKVSTSKSDVWSFGVVLWEIFAFGRAPYPRMGQKEVVDAVVKGY 425
Query: 659 RPSQPSYVGDELF-QVCLQCWQVDPDERPTFSSLVIELT 696
R P E++ ++ + CW++DP +RPTF +L+ L+
Sbjct: 426 RMECPDTCPKEVYDKIMMACWEIDPVKRPTFKTLMRALS 464
>UniRef50_P16591 Cluster: Proto-oncogene tyrosine-protein kinase
FER; n=109; root|Rep: Proto-oncogene tyrosine-protein
kinase FER - Homo sapiens (Human)
Length = 822
Score = 135 bits (326), Expect = 5e-30
Identities = 71/231 (30%), Positives = 123/231 (53%), Gaps = 19/231 (8%)
Query: 474 ELEKTEKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQR 533
+L + K + LQE +L K +H N++ LIG+C + +++E + + L R++
Sbjct: 596 DLPQELKIKFLQEAKIL-KQYDHPNIVKLIGVCTQRQPVYIIMELVSGG-DFLTFLRRKK 653
Query: 534 DIQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLS 593
D + ++++ + A GM YL ++ +H+ L RN ++ EN +KI+ FG+S
Sbjct: 654 D-------ELKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMS 706
Query: 594 HLRS--------LHETPDYTRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHS 645
L + P +WT+ E L RY+ ++DVWSFG+L+WE +LG PY
Sbjct: 707 RQEDGGVYSSSGLKQIP--IKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGM 764
Query: 646 GNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELT 696
N+ ++ RG R S P + +++ ++ ++CW P+ RP FS L ELT
Sbjct: 765 TNQQAREQVERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQKELT 815
>UniRef50_Q4RXB0 Cluster: Chromosome 11 SCAF14979, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 11 SCAF14979, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 1078
Score = 134 bits (325), Expect = 6e-30
Identities = 84/245 (34%), Positives = 136/245 (55%), Gaps = 29/245 (11%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTL-LVVLEDIK--------KTLKEMLL- 528
E Q L+E L++K +H N++SL+GI L LVVL +K ++ K + +
Sbjct: 784 EVNQFLRE-GLIMKGFDHPNILSLLGIMLPKEGLPLVVLPYMKHGDVRHFIRSEKRVFIC 842
Query: 529 ---LSRQRDIQNN--KFCSITENKVLQICV----QVARGMEYLHTRKIVHKKLCCRNMII 579
L++Q D + F + +N ++ + QVA+GMEYL +K VH+ L RN ++
Sbjct: 843 ICGLTKQEDNRELCLTFLCLPQNPTVKDLIGFGLQVAKGMEYLAQKKFVHRDLAARNCML 902
Query: 580 SENGTVKIAGFGLS---HLRSLHETPDY------TRWTSHEMLRQTRYNPKADVWSFGVL 630
E TVK+A FG++ + + + D+ +W + E L+ ++ K+DVWS+G+L
Sbjct: 903 DETYTVKVADFGMARDIYDKEYYSIQDHKQVKLPVKWMALESLQTQKFTIKSDVWSYGIL 962
Query: 631 MWEVLTLGATPYSHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSS 690
MWE+LT GA+PY D+ +L+G R QP + D L+ + L CW +PD RP+FSS
Sbjct: 963 MWELLTRGASPYPDVDPYDITHYLLKGRRLPQPQFCPDTLYSIMLSCWDPEPDYRPSFSS 1022
Query: 691 LVIEL 695
L ++
Sbjct: 1023 LTADV 1027
>UniRef50_Q17J18 Cluster: Tyrosine-protein kinase; n=4;
Endopterygota|Rep: Tyrosine-protein kinase - Aedes
aegypti (Yellowfever mosquito)
Length = 959
Score = 134 bits (325), Expect = 6e-30
Identities = 76/233 (32%), Positives = 125/233 (53%), Gaps = 20/233 (8%)
Query: 481 KQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKK-TLKEMLLLSRQRDIQNNK 539
K ++ E++++ +H N+I+L+G C + L V++E LK+ L R
Sbjct: 672 KDLVCEMEVMKMIGKHVNIINLLGCCCKDGPLYVIVEYAPHGNLKDFLRSHRFGTANYED 731
Query: 540 FCS-------ITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGL 592
S +T+ +++ Q+ARGME+L +R+ +H+ L RN+++S+ +KIA FGL
Sbjct: 732 MISGEKEKKILTQKELISFAYQIARGMEHLASRRCIHRDLAARNVLVSDGYVMKIADFGL 791
Query: 593 SHLRSLHETPDYT---------RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYS 643
+ R +H Y RW + E L + Y+ ++DVWSFGVL+WE++TLG PYS
Sbjct: 792 A--RDIHSQEYYRKTTTGKLPIRWMAPESLEEKFYDSQSDVWSFGVLLWEIMTLGGNPYS 849
Query: 644 HSGNKD-VGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIEL 695
D + + +G R QP +++ +CW P+ERPTFS +V L
Sbjct: 850 SIPTWDNLLEHLKKGKRLEQPPLCSIDIYLFMRECWHYRPEERPTFSEIVQHL 902
>UniRef50_Q59F30 Cluster: Fibroblast growth factor receptor 4
variant; n=28; Eumetazoa|Rep: Fibroblast growth factor
receptor 4 variant - Homo sapiens (Human)
Length = 1034
Score = 134 bits (325), Expect = 6e-30
Identities = 73/226 (32%), Positives = 122/226 (53%), Gaps = 18/226 (7%)
Query: 483 MLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKK-TLKEMLLLSR------QRDI 535
++ E++++ H+N+I+L+G+C L V++E K L+E L R D
Sbjct: 749 LVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDG 808
Query: 536 QNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHL 595
+ ++ ++ QVARGM+YL +RK +H+ L RN++++E+ +KIA FGL+
Sbjct: 809 PRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLA-- 866
Query: 596 RSLHETPDY---------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSG 646
R +H Y +W + E L Y ++DVWSFG+L+WE+ TLG +PY
Sbjct: 867 RGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIP 926
Query: 647 NKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLV 692
+++ S + G R +P + EL+ + +CW P +RPTF LV
Sbjct: 927 VEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLV 972
>UniRef50_Q86PM4 Cluster: Fibroblast growth factor receptor
precursor; n=1; Hydra vulgaris|Rep: Fibroblast growth
factor receptor precursor - Hydra attenuata (Hydra)
(Hydra vulgaris)
Length = 816
Score = 134 bits (325), Expect = 6e-30
Identities = 76/281 (27%), Positives = 137/281 (48%), Gaps = 17/281 (6%)
Query: 428 WNIPRNLIETDISCVVGVGTYXXXXXXXXXXXXXXXXXXXXXIADRELEKTEK--KQMLQ 485
W I +ETD C++G G + + + + E+ K +
Sbjct: 467 WEIKLEQLETD--CLLGEGAFGRVFRATARDLPNHTGVQTVAVKMLKEDCCEQDLKDFIS 524
Query: 486 ELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNKFCS--I 543
E++++ +H N+++L+ + L +V+E + L + +Q N + I
Sbjct: 525 EIEVMKSIGKHINILNLLAVSSQQGKLYIVVEYCRHGNLRSFLKDNRPVMQANSVITKKI 584
Query: 544 TENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSLHETPD 603
T + C+QVARGM +L ++K +H+ + RN+++ E +KIA FGL+ R +HE
Sbjct: 585 TLYDLTSFCLQVARGMNFLASKKCIHRDIAARNVLVGEGYLMKIADFGLA--RDIHEQDY 642
Query: 604 Y---------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRI 654
Y +W + E L Y ++D+WSFG+L WE++T G +PY + + +
Sbjct: 643 YRKCTDGRLPVKWMAIEALFDRVYTTQSDIWSFGILAWEIVTFGGSPYPGIALEKLFDLL 702
Query: 655 LRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIEL 695
+G R +P D+++ + L CW+ P +RPTFS L+ +L
Sbjct: 703 KQGYRMERPLNCTDDMYTLMLNCWKEIPSKRPTFSQLIEDL 743
>UniRef50_Q8JG38 Cluster: Fibroblast growth factor receptor 2
precursor; n=11; Eumetazoa|Rep: Fibroblast growth factor
receptor 2 precursor - Danio rerio (Zebrafish)
(Brachydanio rerio)
Length = 817
Score = 134 bits (325), Expect = 6e-30
Identities = 79/238 (33%), Positives = 125/238 (52%), Gaps = 20/238 (8%)
Query: 476 EKTEK--KQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKK-TLKEMLLLSR- 531
+ TEK ++ E++++ H+N+I+L+G C + L V++E K L+E L R
Sbjct: 518 DATEKDLSDLVSEMEMMKMIGRHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRP 577
Query: 532 -----QRDIQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVK 586
DI +T ++ QVARGMEYL ++K +H+ L RN++++E+ +K
Sbjct: 578 PGMEYSYDIARVSDEPLTFKDLVSCTYQVARGMEYLASQKCIHRDLAARNVLVTESNVMK 637
Query: 587 IAGFGLSHLRSLHETPDY---------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTL 637
IA FGL+ R +H Y +W + E L Y ++DVWSFGVLMWE+ TL
Sbjct: 638 IADFGLA--RDVHNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTL 695
Query: 638 GATPYSHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIEL 695
G +PY +++ + G R +P+ +EL+ + CW RPTF LV +L
Sbjct: 696 GGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMKDCWHAISSHRPTFKQLVEDL 753
>UniRef50_A7SL46 Cluster: Predicted protein; n=2; Eumetazoa|Rep:
Predicted protein - Nematostella vectensis
Length = 252
Score = 134 bits (323), Expect = 1e-29
Identities = 75/236 (31%), Positives = 124/236 (52%), Gaps = 19/236 (8%)
Query: 481 KQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEML-LLSRQRDIQNNK 539
++ L+E+ L+ K H+N+++ + ++V+E + K ++L L R R QN++
Sbjct: 12 EEFLKEISLMKKLGSHKNIVNFLCCSTVKEPFMLVVEFLPKG--DLLDYLRRNRSKQNDE 69
Query: 540 FCS-----ITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSH 594
IT +L Q+A GMEYL + VH+ L RN+++++N VK+A FGL+
Sbjct: 70 TGEQEDEMITPQDLLSFSYQIAAGMEYLSKKGFVHRDLAARNVLVADNKQVKVADFGLT- 128
Query: 595 LRSLHETPDYT---------RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHS 645
R L+E Y +W S E + + ++DVWS+GV++WE+ TLG PY
Sbjct: 129 -RDLYEESAYQGHSNRKLPIKWMSPEAIYDQIFTTESDVWSYGVVLWEIATLGGAPYPTI 187
Query: 646 GNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEA 701
+DV + G R +P DE++ + CW+ P +RPTFS L ++ EA
Sbjct: 188 STRDVFVMLRSGYRMEKPDICSDEVYTIMKHCWEDQPKKRPTFSDLRMKFEYMLEA 243
>UniRef50_P13368 Cluster: Protein sevenless; n=20; Eumetazoa|Rep:
Protein sevenless - Drosophila melanogaster (Fruit fly)
Length = 2554
Score = 134 bits (323), Expect = 1e-29
Identities = 79/239 (33%), Positives = 130/239 (54%), Gaps = 23/239 (9%)
Query: 470 IADRELEK--TEKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKK-TLKEM 526
+A + L K +E ++LQE L+ +HEN++ L+GIC ++ +++E ++ L
Sbjct: 2239 VAIKSLRKGASEFAELLQEAQLM-SNFKHENIVCLVGICFDTESISLIMEHMEAGDLLSY 2297
Query: 527 LLLSRQRDIQNNK-FCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENG-- 583
L +R Q + ++ +++L +C+ VA G YL VH+ L CRN +++E+
Sbjct: 2298 LRAARATSTQEPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGS 2357
Query: 584 -----TVKIAGFGLSHLRSLHETPDY---------TRWTSHEMLRQTRYNPKADVWSFGV 629
TVKI FGL+ R ++++ Y RW S E L + ++DVW+FGV
Sbjct: 2358 TDRRRTVKIGDFGLA--RDIYKSDYYRKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGV 2415
Query: 630 LMWEVLTLGATPYSHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTF 688
L WE+LTLG PY+ N +V + + G R QP ++L+ + L CW+ DP ERP+F
Sbjct: 2416 LCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSF 2474
>UniRef50_P08069 Cluster: Insulin-like growth factor 1 receptor
precursor (EC 2.7.10.1) (Insulin-like growth factor I
receptor) (IGF-I receptor) (CD221 antigen) [Contains:
Insulin-like growth factor 1 receptor alpha chain;
Insulin-like growth factor 1 receptor beta chain]; n=47;
Euteleostomi|Rep: Insulin-like growth factor 1 receptor
precursor (EC 2.7.10.1) (Insulin-like growth factor I
receptor) (IGF-I receptor) (CD221 antigen) [Contains:
Insulin-like growth factor 1 receptor alpha chain;
Insulin-like growth factor 1 receptor beta chain] - Homo
sapiens (Human)
Length = 1367
Score = 132 bits (320), Expect = 2e-29
Identities = 76/241 (31%), Positives = 130/241 (53%), Gaps = 14/241 (5%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNN 538
E+ + L E ++ + + H +V+ L+G+ LV++E + + + L S + +++NN
Sbjct: 1043 ERIEFLNEASVMKEFNCH-HVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENN 1101
Query: 539 KFCSITE-NKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRS 597
+ +K++Q+ ++A GM YL+ K VH+ L RN +++E+ TVKI FG++ R
Sbjct: 1102 PVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMT--RD 1159
Query: 598 LHETPDY---------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNK 648
++ET Y RW S E L+ + +DVWSFGV++WE+ TL PY N+
Sbjct: 1160 IYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNE 1219
Query: 649 DVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEAPGTRNLS 708
V ++ G +P D LF++ CWQ +P RP+F ++ + E PG R +S
Sbjct: 1220 QVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEME-PGFREVS 1278
Query: 709 F 709
F
Sbjct: 1279 F 1279
>UniRef50_Q9Y1Z0 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 485
Score = 132 bits (319), Expect = 3e-29
Identities = 69/223 (30%), Positives = 117/223 (52%), Gaps = 11/223 (4%)
Query: 472 DRELEKTEKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSR 531
D ++ K Q L E ++ T H N++ LIGI + + ++ E + K L SR
Sbjct: 257 DHLKDEKAKTQFLAEASVMT-TLRHPNLVCLIGISLDDNPIYLITEFMAKGSLIDYLRSR 315
Query: 532 QRDIQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFG 591
R + IT+ + V +GM YL ++ VH+ L RN++I+E+ K++ FG
Sbjct: 316 GRAV-------ITKQNQIDFARDVVKGMVYLESQNFVHRDLAARNVLIAEDNVAKVSDFG 368
Query: 592 LSHLRSLHETPDY---TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNK 648
L+ S + +WT+ E LR+ +++ K DVWSFGVL+WE+ + G PY +
Sbjct: 369 LAKSSSNVKQEGAKLPVKWTAPEALRENKFSNKTDVWSFGVLLWEIYSYGRVPYPRVPVE 428
Query: 649 DVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSL 691
DV + + G R P D+++++ + CW+ DP +RP F+ +
Sbjct: 429 DVANHVENGYRMESPDGCPDQIYKIMMDCWEKDPSQRPNFTRI 471
>UniRef50_Q09147 Cluster: Fibroblast growth factor receptor homolog
2 precursor; n=4; Coelomata|Rep: Fibroblast growth
factor receptor homolog 2 precursor - Drosophila
melanogaster (Fruit fly)
Length = 1052
Score = 132 bits (319), Expect = 3e-29
Identities = 79/293 (26%), Positives = 150/293 (51%), Gaps = 32/293 (10%)
Query: 428 WNIPRNLIETDISCVVGVGTYXXXXXXXXXXXXXXXXXXXXXIADRELEK----TEKKQM 483
W IPR + + ++G G + +A + +++ T+ +
Sbjct: 705 WEIPRQ--QLSLGSILGEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMASL 762
Query: 484 LQELDLLIKTSEHENVISLIGICETNTTLLVVLE-----DIKKTLKEMLLLSRQRDIQNN 538
++E++++ +H N+I+L+G C L V++E ++K LK+ + QR ++
Sbjct: 763 VREMEVMKMIGKHINIINLLGCCSQGGPLWVIVEYAPHGNLKDFLKQNRPGAPQRRSDSD 822
Query: 539 KFCS---------ITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAG 589
+ + E ++ + Q+ARGMEYL +R+ +H+ L RN+++S+ +KIA
Sbjct: 823 GYLDDKPLISTQHLGEKELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIAD 882
Query: 590 FGLSHLRSLHETPDYTR---------WTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGAT 640
FGL+ R + +T Y + W + E L++ +Y+ ++DVWS+GVL+WE++T G
Sbjct: 883 FGLA--RDIQDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQ 940
Query: 641 PYSH-SGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLV 692
PY H +++ S ++ G R +P+ ++ V QCW + RPTF+ LV
Sbjct: 941 PYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELV 993
>UniRef50_Q4S1S8 Cluster: Chromosome undetermined SCAF14764, whole
genome shotgun sequence; n=1; Tetraodon
nigroviridis|Rep: Chromosome undetermined SCAF14764,
whole genome shotgun sequence - Tetraodon nigroviridis
(Green puffer)
Length = 635
Score = 132 bits (318), Expect = 4e-29
Identities = 72/233 (30%), Positives = 128/233 (54%), Gaps = 18/233 (7%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKK-TLKEMLLLSRQRDIQ- 536
++ ++ E++++ +H+N+I+L+G C + L V++E K L++ L R ++
Sbjct: 394 DRADLISEMEMMKMIGKHKNIINLLGACTQDGPLYVLVEYASKGNLRDYLRARRPAGLEY 453
Query: 537 --NNKFCSITENKVLQI---CVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFG 591
+++ S+ +++++ QVARGM YL ++K +H+ L RN++++E+ +KIA FG
Sbjct: 454 WSSSRPVSLASMEIMELVSAAYQVARGMAYLASKKCIHRDLAARNVLVTEDNVMKIADFG 513
Query: 592 LSHLRSLHETPDY---------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPY 642
L+ R +H Y +W + E L Y ++DVWSFGVL+WE+ TLG +PY
Sbjct: 514 LA--RDVHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPY 571
Query: 643 SHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIEL 695
+++ + G R +P EL+ + CW P RPTF LV +L
Sbjct: 572 PGVPVEELFKLLKEGHRMEKPPTSTQELYLMMRGCWHAVPARRPTFQQLVEDL 624
>UniRef50_Q1JUB8 Cluster: Fibroblast growth factor receptor; n=2;
Obtectomera|Rep: Fibroblast growth factor receptor -
Bombyx mori (Silk moth)
Length = 856
Score = 132 bits (318), Expect = 4e-29
Identities = 73/235 (31%), Positives = 125/235 (53%), Gaps = 22/235 (9%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKK-TLKEMLLLSR------ 531
E ++ E++++ +H N+I+L+G C + L V++E L+E L R
Sbjct: 584 EMMALVSEMEMMKMIGKHVNIINLLGCCTQDGPLYVIVEYAPNGNLREFLRNHRPGNRYE 643
Query: 532 --QRDIQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAG 589
D++ K ++T+ ++ QVARGMEYL +R+ +H+ RN+++S++ +KIA
Sbjct: 644 SPNEDLKEKK--TLTQKDLVSFSYQVARGMEYLASRRCIHRDSAARNVLVSDDCVLKIAD 701
Query: 590 FGLSHLRSLHETPDY---------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGAT 640
FGL+ + +H Y RW + E L + + DVWSFGVL+WE++TLG T
Sbjct: 702 FGLA--KDVHSNDYYRKKTEGRLPVRWMAPESLYHKVFTTQTDVWSFGVLLWEIMTLGGT 759
Query: 641 PYSHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIEL 695
PY + + + G R +P E++ + +CW P +RP+F+ LV +L
Sbjct: 760 PYPTVPGQYMYQHLSAGHRMEKPPCCSLEIYMLMRECWSFSPGDRPSFTELVEDL 814
>UniRef50_A7RGW8 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 337
Score = 132 bits (318), Expect = 4e-29
Identities = 69/230 (30%), Positives = 124/230 (53%), Gaps = 19/230 (8%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLE-----DIKKTLKEMLLLSRQR 533
+++ L E++++ + +H N++S++G L ++ E D++ L+ + R
Sbjct: 64 DRRNFLSEIEMMKQLGKHLNIVSILGCVTHAGQLCLITEYCPYGDLRNYLRAIRDKVSTR 123
Query: 534 DIQNNKFCS--ITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFG 591
D + +T+N +L Q+A GMEYL + VH+ L RN++I E+ VKI+ FG
Sbjct: 124 DSLAGRAPGRELTQNDLLSFARQIAVGMEYLSQKMFVHRDLAARNILICEDNLVKISDFG 183
Query: 592 LSHLRSLHETPDY----------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATP 641
L+ R ++E+ +Y +W + E + Q + K+DVW+FGV++WE++TLG +P
Sbjct: 184 LT--RDVYESSEYHKMHNTGKLPLKWMAPEAIFQNVHTTKSDVWAFGVVLWEIVTLGGSP 241
Query: 642 YSHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSL 691
Y K+ ++ G R +P EL+ + CW P++RPTF+ L
Sbjct: 242 YPGQSGKEFYKKLKNGYRMEKPDMCSPELYAMMRSCWASSPEDRPTFTKL 291
>UniRef50_Q7YZW6 Cluster: Putative uncharacterized protein; n=3;
Caenorhabditis|Rep: Putative uncharacterized protein -
Caenorhabditis elegans
Length = 276
Score = 131 bits (317), Expect = 6e-29
Identities = 61/221 (27%), Positives = 125/221 (56%), Gaps = 7/221 (3%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKK-TLKEMLLLSRQRDIQN 537
E+++ ++E+ ++ +H+N++++ G C +++E + LK L R+ +
Sbjct: 39 EREEFVREIQMMQTVGQHDNIVTMYGYCMDEQLQCMIMEYVPYGDLKHYLQNMRK---EK 95
Query: 538 NKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSH--- 594
+ +I + L Q+A GM +L + I+H+ L RN+++ +KI+ FG+S
Sbjct: 96 DSDSAIDSKEFLSFTNQIACGMAHLESVGIIHRDLAARNILVGTGKVLKISDFGMSRPGV 155
Query: 595 LRSLHETPDYTRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRI 654
+ + RW S E ++ Y+ K+DVW+FGVL+WE+ TLG PY++ +KD+ +++
Sbjct: 156 YIKMSKGVIPLRWLSPEAIKDNTYSNKSDVWAFGVLLWEIATLGGFPYNNVADKDILNQL 215
Query: 655 LRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIEL 695
GMR QP+ D+++ + CW + ++RP+F +++ ++
Sbjct: 216 TEGMRLEQPAKCSDDMYILMKSCWNLKAEDRPSFLAILSKI 256
>UniRef50_P08630 Cluster: Tyrosine-protein kinase Btk29A; n=10;
Endopterygota|Rep: Tyrosine-protein kinase Btk29A -
Drosophila melanogaster (Fruit fly)
Length = 786
Score = 131 bits (316), Expect = 7e-29
Identities = 68/218 (31%), Positives = 111/218 (50%), Gaps = 13/218 (5%)
Query: 484 LQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNKFCSI 543
++E ++ K +H N++ L G+C + + +V E +K L ++ + N
Sbjct: 567 IEEAKVMTKL-QHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNM---- 621
Query: 544 TENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHL------RS 597
+L +C+QV++GM YL +H+ L RN ++ VK+A FGL+ S
Sbjct: 622 --GLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTS 679
Query: 598 LHETPDYTRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRILRG 657
T +W E+L TR++ K+DVW++GVLMWE+ T G PY N +V R+ RG
Sbjct: 680 SGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRG 739
Query: 658 MRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIEL 695
+ +P E++ V CW P+ERP F L+ +L
Sbjct: 740 IILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQL 777
>UniRef50_UPI0000F1FB23 Cluster: PREDICTED: similar to tyrosine
protein kinase BTK; n=1; Danio rerio|Rep: PREDICTED:
similar to tyrosine protein kinase BTK - Danio rerio
Length = 596
Score = 130 bits (315), Expect = 1e-28
Identities = 69/215 (32%), Positives = 109/215 (50%), Gaps = 15/215 (6%)
Query: 484 LQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNKFCSI 543
++E +++K H N++ L G+C + +V E + LL Q + N
Sbjct: 378 IEEAKVMMKLC-HGNLVQLYGVCTKQRPIYIVTEYLANGC---LLNYLQEGLLNP----- 428
Query: 544 TENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSLHETPD 603
T +L++C V+ GM+YL + +H+ L RN ++ NGT+K+ FGLS E
Sbjct: 429 TSIALLEMCKDVSEGMKYLEANQFIHRDLAARNCLVDSNGTIKVTDFGLSRYVLDDEYTS 488
Query: 604 YT------RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRILRG 657
RW+ E+L +++ K+D+W+FGVLMWE+ T G PY N ++ +I G
Sbjct: 489 SVGSKFPVRWSPPEVLLYCKFSSKSDIWAFGVLMWEIYTQGRMPYDRWNNTEIVEKISAG 548
Query: 658 MRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLV 692
R +P + +F + CW PDERPTF LV
Sbjct: 549 HRLYRPQMANENVFAIMNSCWHERPDERPTFQELV 583
>UniRef50_UPI000065F6B2 Cluster: Receptor tyrosine-protein kinase
erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine
kinase-type cell surface receptor HER4).; n=1; Takifugu
rubripes|Rep: Receptor tyrosine-protein kinase erbB-4
precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine
kinase-type cell surface receptor HER4). - Takifugu
rubripes
Length = 1236
Score = 130 bits (315), Expect = 1e-28
Identities = 71/237 (29%), Positives = 124/237 (52%), Gaps = 20/237 (8%)
Query: 476 EKTEKKQMLQELD--LLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQR 533
E T K ++ +D L++ + EH +++ L+G+C + T LV + + LL
Sbjct: 707 EATGPKANVEFMDEALIMASMEHPHLVRLLGVCLSPTIQLVT-----QLMPHGCLLDYVH 761
Query: 534 DIQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLS 593
+ ++N I +L CVQ+A+GM YL R++VH+ L RN+++ +KI FGL+
Sbjct: 762 EHKDN----IGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHIKITDFGLA 817
Query: 594 HLRSLHETPDYT--------RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHS 645
L ++E +Y +W + E + ++ ++DVWS+GV +WE++T G PY
Sbjct: 818 RLLDVNEK-EYNADGGKMAIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGI 876
Query: 646 GNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEAP 702
+D+ + +G R QP +++ V ++CW +D D RP F L E T + P
Sbjct: 877 STRDIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFTRMARDP 933
>UniRef50_Q9BLY1 Cluster: Receptor tyrosine kinase; n=5;
Caenorhabditis|Rep: Receptor tyrosine kinase -
Caenorhabditis elegans
Length = 928
Score = 130 bits (315), Expect = 1e-28
Identities = 79/244 (32%), Positives = 121/244 (49%), Gaps = 11/244 (4%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNN 538
E+ Q+ QE+ + T +H NVI LIG+C + +LL V E + LL R ++
Sbjct: 634 ERAQLEQEIRA-VATFDHPNVIKLIGVCYMDNSLLAVFEYMVHGDLHELLKVRVPPADHD 692
Query: 539 KFCSITENKV--LQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGL---- 592
ITE L I Q+A GMEYL + VH+ L RN ++ + T+KIA FGL
Sbjct: 693 -MGGITEANAEFLYIATQIALGMEYLASMSFVHRDLATRNCLVGDTRTIKIADFGLMRTS 751
Query: 593 ---SHLRSLHETPDYTRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKD 649
+ + LH + RW S E + Q R++ +DVWSFGV +WE+ + G PY + N+
Sbjct: 752 YGSDYYKMLHRSWMPVRWMSKEAIEQGRFSEASDVWSFGVTLWEIWSFGRQPYEGASNQQ 811
Query: 650 VGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEAPGTRNLSF 709
V + P ++ + ++CW + + RPTFS + L +S A ++
Sbjct: 812 VIELVANRHLLECPHNCPTNIYSLMVECWHENIERRPTFSEIRSRLQSWSLASPAHSILQ 871
Query: 710 THYN 713
H N
Sbjct: 872 QHNN 875
>UniRef50_Q8INU0 Cluster: CG14396-PD, isoform D; n=10; Sophophora|Rep:
CG14396-PD, isoform D - Drosophila melanogaster (Fruit
fly)
Length = 1237
Score = 130 bits (315), Expect = 1e-28
Identities = 92/329 (27%), Positives = 150/329 (45%), Gaps = 22/329 (6%)
Query: 382 QFVRMQRGSQSMPLSLSEPCVEIENSGFILEDEERVDYYGNLKRKLWNIPRNLIETDISC 441
+ ++ + G QSM S + E F L + + + K W PR ++ D
Sbjct: 721 KMLQRRLGKQSMTTSSKQALPESGGGDFALMPLQSGFRFESGDAK-WEFPREKLQLDT-- 777
Query: 442 VVGVGTYXXXXXXXXXXXXXXXXXXXXXIA--DRELEKTEKKQMLQELDLLIKTSEHENV 499
V+G G + + + E +L E LL + S H NV
Sbjct: 778 VLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEVS-HPNV 836
Query: 500 ISLIGICETNTTLLVVLEDIKK-TLKEMLLLSRQRDIQNNKFCSITE----NKVLQICVQ 554
I L+G C ++ L+++E + +L+ L LSR+ + F E VL Q
Sbjct: 837 IKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFADGVEPVNVKMVLTFAWQ 896
Query: 555 VARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSLHETPDY---------T 605
+ +GM YL K+VH+ L RN+++++ KI+ FGL+ R ++E Y
Sbjct: 897 ICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLT--RDVYEDDAYLKRSRDRVPV 954
Query: 606 RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRILRGMRPSQPSY 665
+W + E L Y K+DVWSFGVL WE++TLGA+PY +++ S + G R +P
Sbjct: 955 KWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPEN 1014
Query: 666 VGDELFQVCLQCWQVDPDERPTFSSLVIE 694
+ ++ + CW +P+ RP+F L E
Sbjct: 1015 CSEAVYSIVRTCWADEPNGRPSFKFLASE 1043
>UniRef50_Q674V1 Cluster: Vascular endothelial growth factor receptor;
n=1; Podocoryne carnea|Rep: Vascular endothelial growth
factor receptor - Podocoryne carnea
Length = 1254
Score = 130 bits (315), Expect = 1e-28
Identities = 73/234 (31%), Positives = 122/234 (52%), Gaps = 18/234 (7%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQN- 537
E K + EL +LI EH+N+++L+G C TN L V+LE + L ++ Q
Sbjct: 908 EYKDLASELKILIHLGEHKNIVNLLGACTTNGKLYVILECCPRGNLLTFLRGKRETFQPV 967
Query: 538 -NKFCSITENK-----VLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFG 591
K+ + EN+ +L I +QVA+ M++L ++K VH+ L RN+++ + +KIA FG
Sbjct: 968 WTKYDTDMENEFTYIDLLMIVIQVAKRMDFLQSQKCVHRDLAARNVLVGPDYIMKIADFG 1027
Query: 592 LSHLRSLHETPDY---------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPY 642
L+ R +++ Y +W + E L Y +D+WS+G+++WE TLG +PY
Sbjct: 1028 LA--RDIYKDEFYLKETTGLLPVKWMAPESLFDKVYTSMSDIWSYGIVLWEAFTLGGSPY 1085
Query: 643 SHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELT 696
+D+ + G R +P +F++ CW P +RP FS + LT
Sbjct: 1086 PGLPTEDLFGFLEDGKRMERPEICPKSVFEIMSDCWTKSPYDRPMFSQIYDRLT 1139
>UniRef50_Q8AXB3 Cluster: Vascular endothelial growth factor receptor
2 precursor; n=10; Euteleostomi|Rep: Vascular endothelial
growth factor receptor 2 precursor - Danio rerio
(Zebrafish) (Brachydanio rerio)
Length = 1302
Score = 130 bits (315), Expect = 1e-28
Identities = 65/158 (41%), Positives = 94/158 (59%), Gaps = 12/158 (7%)
Query: 554 QVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSLHETPDYTR------- 606
QVA+GME+L +RK +H+ L RN+++SEN VKI FGL+ R +++ PDY R
Sbjct: 986 QVAKGMEFLASRKCIHRDLAARNILLSENNVVKICDFGLA--RDVYKDPDYVRKGDARLP 1043
Query: 607 --WTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSG-NKDVGSRILRGMRPSQP 663
W + E + Y ++DVWSFGVLMWE+ +LGA+PY +++ R+ G R P
Sbjct: 1044 LKWMAPEAIFDKIYTTQSDVWSFGVLMWEIFSLGASPYPGLHIDEEFCCRLKEGTRMKAP 1103
Query: 664 SYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEA 701
Y E++Q L CW +P +RPTF+ LV L +A
Sbjct: 1104 EYSSSEIYQTMLDCWHGEPSQRPTFTELVERLGDLLQA 1141
>UniRef50_Q08881 Cluster: Tyrosine-protein kinase ITK/TSK; n=18;
Euteleostomi|Rep: Tyrosine-protein kinase ITK/TSK - Homo
sapiens (Human)
Length = 620
Score = 130 bits (315), Expect = 1e-28
Identities = 71/228 (31%), Positives = 117/228 (51%), Gaps = 15/228 (6%)
Query: 480 KKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNK 539
++ ++E ++++K S H ++ L G+C + +V E E LS Q
Sbjct: 400 EEDFIEEAEVMMKLS-HPKLVQLYGVCLEQAPICLVFE-----FMEHGCLSDYLRTQRGL 453
Query: 540 FCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHL---- 595
F + T +L +C+ V GM YL ++H+ L RN ++ EN +K++ FG++
Sbjct: 454 FAAET---LLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDD 510
Query: 596 --RSLHETPDYTRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSR 653
S T +W S E+ +RY+ K+DVWSFGVLMWEV + G PY + N +V
Sbjct: 511 QYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVED 570
Query: 654 ILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEA 701
I G R +P ++Q+ CW+ P++RP FS L+ +L +E+
Sbjct: 571 ISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEIAES 618
>UniRef50_Q7PWP1 Cluster: ENSANGP00000013218; n=2; Culicidae|Rep:
ENSANGP00000013218 - Anopheles gambiae str. PEST
Length = 861
Score = 130 bits (314), Expect = 1e-28
Identities = 76/223 (34%), Positives = 122/223 (54%), Gaps = 17/223 (7%)
Query: 483 MLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKK-TLKEMLLLSRQRDIQN---- 537
+L E LL + + H NVI L+G C + L+++E + +LK L LSR+ ++ N
Sbjct: 535 LLSEYQLLQEVN-HPNVIRLLGACTKGDSPLLIIEYCQYGSLKNYLRLSRKLEVLNADYE 593
Query: 538 NKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRS 597
N IT +L Q+++GM YL K+VH+ L RN++++E KI+ FGL+ R
Sbjct: 594 NAVEPITVKDILSFAWQISKGMAYLTDIKLVHRDLAARNVLLAEGKVCKISDFGLT--RD 651
Query: 598 LHETPDY---------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNK 648
++E Y +W + E L Y K+DVW+FGVL WE++TLGA+PY +
Sbjct: 652 VYEDDAYLKKSKDRVPVKWMAPESLADHIYTTKSDVWAFGVLCWELITLGASPYPGIPPQ 711
Query: 649 DVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSL 691
++ + + +G R P +E++ + CW DP +RP+F L
Sbjct: 712 NLYNLLKQGYRMECPKNCSEEIYGIVRLCWADDPKQRPSFKHL 754
>UniRef50_Q03142 Cluster: Fibroblast growth factor receptor 4
precursor; n=9; Eutheria|Rep: Fibroblast growth factor
receptor 4 precursor - Mus musculus (Mouse)
Length = 799
Score = 130 bits (314), Expect = 1e-28
Identities = 72/226 (31%), Positives = 120/226 (53%), Gaps = 18/226 (7%)
Query: 483 MLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKK-TLKEMLLLSR------QRDI 535
++ E++++ H+N+I+L+G+C L V++E K L+E L R D
Sbjct: 514 LVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDG 573
Query: 536 QNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHL 595
+ ++ ++ QVARGM+YL +RK +H+ L RN++++E+ +KIA FGL+
Sbjct: 574 PRSSEGPLSFPALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDDVMKIADFGLA-- 631
Query: 596 RSLHETPDY---------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSG 646
R +H Y +W + E L Y ++DVWSF +L+WE+ TLG +PY
Sbjct: 632 RGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFEILLWEIFTLGGSPYPGIP 691
Query: 647 NKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLV 692
+++ S + G R +P EL+ + +CW P +RPTF LV
Sbjct: 692 VEELFSLLREGHRMERPPNCPSELYGLMRECWHAAPSQRPTFKQLV 737
>UniRef50_Q4S351 Cluster: Chromosome 4 SCAF14752, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 4 SCAF14752, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 810
Score = 130 bits (313), Expect = 2e-28
Identities = 70/230 (30%), Positives = 122/230 (53%), Gaps = 19/230 (8%)
Query: 474 ELEKTEKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQR 533
+L K + L E +L K +H N++ LIG+C + +V+E + + L +++
Sbjct: 586 DLPSELKIRFLSEARIL-KQYDHPNIVKLIGVCTQRQPIYIVMELVPGG-DFLSYLRKKK 643
Query: 534 DIQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLS 593
D K ++L+ V A GM YL ++ +H+ L RN ++ +N +KI+ FG+S
Sbjct: 644 DELKTK-------QLLRFAVDAAAGMAYLESKNCIHRDLAARNCLVGDNNALKISDFGMS 696
Query: 594 HLRS--------LHETPDYTRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHS 645
L + P +WT+ E L RY+ ++DVWS+G+L+WE +LG PY
Sbjct: 697 RQEDDGIYSSSGLKQIP--IKWTAPEALNYGRYSSESDVWSYGILLWETFSLGMCPYPGM 754
Query: 646 GNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIEL 695
N+ ++ +G R + P D++++V +CWQ +P++RP FS L +L
Sbjct: 755 TNQQAREQVEKGYRMACPQRCPDDVYKVMQRCWQYNPEDRPKFSELQRDL 804
>UniRef50_Q8WRF4 Cluster: Receptor tyrosine kinase; n=1; Monosiga
brevicollis|Rep: Receptor tyrosine kinase - Monosiga
brevicollis
Length = 1476
Score = 130 bits (313), Expect = 2e-28
Identities = 74/220 (33%), Positives = 117/220 (53%), Gaps = 11/220 (5%)
Query: 480 KKQMLQELDLLIKTSEHENVISLIGIC--ETNTTLLVVLEDIKKTLKEMLLLSRQRDIQN 537
++ L E+ ++ + H NVI +IG C ET LLV L + +++ L R +N
Sbjct: 770 RQDFLSEMTVMKEIGAHPNVIGIIGHCLRETPQILLVELAEFGN-MRDYLRGCRATQ-EN 827
Query: 538 NKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRS 597
+ +I +++ C+Q+ARGM +L + ++H+ L RN+++ +N KI+ FGL+
Sbjct: 828 PQ--TIRVDQMADFCLQIARGMAFLEQKNVIHRDLAARNVLVDKNFECKISDFGLARSIE 885
Query: 598 LHE-----TPDYTRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGS 652
E T +W + E L+ Y K+DVWSFGV MWE+ +LG TPY N+DV S
Sbjct: 886 GGEYKTTATKLPVKWMAPESLKSRIYTTKSDVWSFGVTMWEIFSLGGTPYKEHQNRDVLS 945
Query: 653 RILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLV 692
+ G R P E + CW ++ +RP+FS LV
Sbjct: 946 FLESGHRLPSPRQAPVEFDDIARMCWVLEASDRPSFSELV 985
>UniRef50_Q7YT64 Cluster: Tyrosine-protein kinase receptor; n=1;
Crassostrea gigas|Rep: Tyrosine-protein kinase receptor
- Crassostrea gigas (Pacific oyster) (Crassostrea
angulata)
Length = 804
Score = 130 bits (313), Expect = 2e-28
Identities = 81/252 (32%), Positives = 134/252 (53%), Gaps = 26/252 (10%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKK-TLKEMLLLSR--QRDI 535
E+ + L E + K +V+ L+G+ L+++E ++K LK L + R + DI
Sbjct: 379 ERMEFLSEASRM-KAFSCNHVVRLLGVVSDGQPALLIMELMEKGDLKNFLRMHRPVEEDI 437
Query: 536 QNNKFCSITEN---------KVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVK 586
+ F I E+ +++Q+ ++A GM YL +K VH+ L RN +++E+ TVK
Sbjct: 438 DST-FAGIKEHISRTPPTIKRIIQMAGEIADGMAYLADKKFVHRDLAARNCMVAEDLTVK 496
Query: 587 IAGFGLSHLRSLHETPDY---------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTL 637
IA FG++ R ++ET Y RW + E L+ + +DVWS+GV++WE+ TL
Sbjct: 497 IADFGMT--RDIYETDYYRKGGKALLPVRWMAPESLKDGIFTSLSDVWSYGVVLWEMATL 554
Query: 638 GATPYSHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTP 697
A PY N++V +L G +P D LF++ +CW+ P +RPTF ++ EL P
Sbjct: 555 AAQPYQGLSNEEVLRYVLNGRVMEKPEDCPDRLFELMQKCWRYRPKQRPTFKEILEELVP 614
Query: 698 FSEAPGTRNLSF 709
+ P N S+
Sbjct: 615 ELD-PSFANKSY 625
>UniRef50_P42680 Cluster: Tyrosine-protein kinase Tec; n=86;
Coelomata|Rep: Tyrosine-protein kinase Tec - Homo
sapiens (Human)
Length = 631
Score = 130 bits (313), Expect = 2e-28
Identities = 71/231 (30%), Positives = 120/231 (51%), Gaps = 15/231 (6%)
Query: 480 KKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNK 539
++ ++E +++K + H ++ L G+C + +V E +++ +L RQR Q +
Sbjct: 407 EEDFIEEAKVMMKLT-HPKLVQLYGVCTQQKPIYIVTEFMERGC--LLNFLRQR--QGH- 460
Query: 540 FCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHL---- 595
+ + +L +C V GMEYL +H+ L RN ++SE G VK++ FG++
Sbjct: 461 ---FSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDD 517
Query: 596 --RSLHETPDYTRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSR 653
S +W E+ +R++ K+DVWSFGVLMWEV T G P+ N +V +
Sbjct: 518 QYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTM 577
Query: 654 ILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEAPGT 704
+ RG R QP + +++V L+CWQ P+ RP+F L+ + E T
Sbjct: 578 VTRGHRLYQPKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVECEET 628
>UniRef50_P42685 Cluster: Tyrosine-protein kinase FRK; n=27;
Fungi/Metazoa group|Rep: Tyrosine-protein kinase FRK -
Homo sapiens (Human)
Length = 505
Score = 130 bits (313), Expect = 2e-28
Identities = 67/220 (30%), Positives = 113/220 (51%), Gaps = 16/220 (7%)
Query: 490 LIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNKFCSITENKVL 549
++K H +I L +C + ++ E ++ S Q +QN+ I + +
Sbjct: 280 IMKNLRHPKLIQLYAVCTLEDPIYIITELMRHG-------SLQEYLQNDTGSKIHLTQQV 332
Query: 550 QICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHL---------RSLHE 600
+ QVA GM YL +R +H+ L RN+++ E+ K+A FGL+ + S HE
Sbjct: 333 DMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHE 392
Query: 601 TPDYTRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRILRGMRP 660
+WT+ E +R +++ K+DVWSFG+L++E++T G PYS V + + R
Sbjct: 393 IKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRL 452
Query: 661 SQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSE 700
QPS + + + L+CW +P ERPTF +L +L + E
Sbjct: 453 PQPSNCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYFE 492
>UniRef50_P18106 Cluster: Tyrosine-protein kinase Fps85D; n=12;
Eumetazoa|Rep: Tyrosine-protein kinase Fps85D -
Drosophila melanogaster (Fruit fly)
Length = 1325
Score = 130 bits (313), Expect = 2e-28
Identities = 71/222 (31%), Positives = 113/222 (50%), Gaps = 14/222 (6%)
Query: 475 LEKTEKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRD 534
L +K++ LQE ++K +H N++ LIGIC +++V+E + LL+ R
Sbjct: 1098 LPDEQKRKFLQE-GRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGS----LLTYLRK 1152
Query: 535 IQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSH 594
N +T + + +C A GM YL ++ +H+ L RN ++ +VKI+ FG+S
Sbjct: 1153 NSNG----LTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSR 1208
Query: 595 LRSLHETPDY-----TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKD 649
+ D +WT+ E L +Y DVWS+G+LMWE+ + G TPYS N
Sbjct: 1209 EEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSR 1268
Query: 650 VGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSL 691
RI G R P +E++++ LQCW D + RP F +
Sbjct: 1269 ARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEI 1310
>UniRef50_Q9Y1Y5 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 557
Score = 129 bits (312), Expect = 2e-28
Identities = 73/229 (31%), Positives = 120/229 (52%), Gaps = 12/229 (5%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGIC---ETNTTLLVVLEDIKKTLKEMLLLSRQRDI 535
E K E ++ +T +H NV+ ++G+C + L+V+ + LK+ L R +
Sbjct: 328 EMKSFFTECSVM-QTLKHPNVLGILGMCFDSPDSIPLMVLPFMVNGNLKDYLKKHRGPHL 386
Query: 536 QNNKFCSITENKVLQ-ICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLS- 593
Q + ++L+ ICV + RGM YL R+ VH+ L RN ++ VK+ FGL+
Sbjct: 387 QLETYPENLSLQMLKRICVDITRGMSYLADRRFVHRDLAARNCLLDSALAVKVGDFGLTR 446
Query: 594 --HLRSLHETPDYTR----WTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGN 647
+L + + P T+ W EML+ + K DVWSFGV WEV + G+TPY N
Sbjct: 447 DIYLTNYYRAPTETKLPVKWMPPEMLQDGVSDEKTDVWSFGVTCWEVFSFGSTPYPGVDN 506
Query: 648 KDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELT 696
+ ++ G+R +P DE++ + +CW +P++RPTF+ L E +
Sbjct: 507 HLMLQHLMSGLRLQKPLLCPDEIYTLMARCWSSNPEDRPTFNELFKEFS 555
>UniRef50_Q4H3B8 Cluster: Tyrosine-protein kinase receptor; n=1;
Ciona intestinalis|Rep: Tyrosine-protein kinase receptor
- Ciona intestinalis (Transparent sea squirt)
Length = 465
Score = 129 bits (312), Expect = 2e-28
Identities = 71/229 (31%), Positives = 121/229 (52%), Gaps = 12/229 (5%)
Query: 478 TEKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQN 537
+++ + L+E ++ + H +V+ L+G+ + +V++E + K + L S + D +
Sbjct: 142 SKRMEFLKEASVMKAFNSH-HVVRLLGVVSMSKRPMVIMEFMAKGDLKTYLRSTRPDAEI 200
Query: 538 NKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRS 597
K + + LQ+C ++A GM YL K VH+ L RN ++ E+ TVKI FGL+ R
Sbjct: 201 RKGDPPSLQQKLQMCGEIADGMSYLSETKYVHRDLAARNCLVHEDLTVKIGDFGLT--RD 258
Query: 598 LHETPDY---------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNK 648
++ET Y RW + E L+ ++ ++DVWSFG+++WE+ TL PY +
Sbjct: 259 VYETDYYRIDSRGILPVRWMAPESLKDGVFDSRSDVWSFGIVLWEIATLAEQPYQGQQHD 318
Query: 649 DVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTP 697
V ++ G QP +L+ + L CW P RPTF +V L+P
Sbjct: 319 QVTRFVIDGGYMEQPKECPSKLYDMMLMCWHYSPSMRPTFLEIVASLSP 367
>UniRef50_P42679 Cluster: Megakaryocyte-associated tyrosine-protein
kinase; n=38; Euteleostomi|Rep: Megakaryocyte-associated
tyrosine-protein kinase - Homo sapiens (Human)
Length = 507
Score = 129 bits (312), Expect = 2e-28
Identities = 70/214 (32%), Positives = 115/214 (53%), Gaps = 11/214 (5%)
Query: 484 LQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNKFCSI 543
L E ++ K +HEN++ L+G+ + L +V+E + K L +R R + N
Sbjct: 274 LDETAVMTKM-QHENLVRLLGVI-LHQGLYIVMEHVSKGNLVNFLRTRGRALVNTA---- 327
Query: 544 TENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHL--RSLHET 601
++LQ + VA GMEYL ++K+VH+ L RN+++SE+ K++ FGL+ + L +
Sbjct: 328 ---QLLQFSLHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSS 384
Query: 602 PDYTRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRILRGMRPS 661
+WT+ E L+ ++ K+DVWSFGVL+WEV + G PY K+V + +G R
Sbjct: 385 RLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRME 444
Query: 662 QPSYVGDELFQVCLQCWQVDPDERPTFSSLVIEL 695
P + + CW+ +P RP F L +L
Sbjct: 445 PPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKL 478
>UniRef50_Q9Y1Y1 Cluster: Protein tyrosine kinase; n=2; cellular
organisms|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 893
Score = 129 bits (311), Expect = 3e-28
Identities = 71/230 (30%), Positives = 119/230 (51%), Gaps = 16/230 (6%)
Query: 473 RELEKTEKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQ 532
R + ++++ LQE ++L K +H N++ LIG+ +L+V+E ++
Sbjct: 665 RSTDVPDREKFLQEAEIL-KQYDHPNIVKLIGVSWDTEPVLIVME--------LMPGGSL 715
Query: 533 RDIQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGL 592
D K +T+ K+L + + GMEYL ++ +H+ L RN ++ EN VKI+ FG+
Sbjct: 716 LDYLRKKAAQMTKGKLLHMSIDACGGMEYLESKNCIHRDLAARNCLVGENDIVKISDFGM 775
Query: 593 SHLRS--LHETPDYTR-----WTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHS 645
S ++ TR WT+ E L RY +DVWSFGVL++EV + G+TPY
Sbjct: 776 SREEEGGMYTVQSGTRQIPIKWTAPEALNYGRYTSASDVWSFGVLLYEVFSGGSTPYPGM 835
Query: 646 GNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIEL 695
N + +++ G R P E+ Q+ CW D ++RP F +++ L
Sbjct: 836 SNAETRTQVDSGYRMPPPQGCPAEIHQIMQLCWAYDAEDRPKFGAVLESL 885
>UniRef50_Q8MY86 Cluster: Fibroblast growth factor receptor 1
precursor; n=2; Dugesia japonica|Rep: Fibroblast growth
factor receptor 1 precursor - Dugesia japonica
(Planarian)
Length = 854
Score = 129 bits (311), Expect = 3e-28
Identities = 65/216 (30%), Positives = 120/216 (55%), Gaps = 7/216 (3%)
Query: 484 LQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKK-TLKEMLLLSRQRDIQNNKFC- 541
++E++++ H NVI L+G+C L V++E L++ + ++ ++ K
Sbjct: 600 VKEMEIMKHIGRHPNVIQLLGLCTQKGPLRVIVELAPYGNLRDFVRAKNKKYSKSKKIIG 659
Query: 542 SITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSLH-- 599
+ T + + +Q+ARGM YL +R +VH+ L RN+++ E+ +KIA FGL+ + +
Sbjct: 660 NFTSSILCTYSLQIARGMTYLASRSVVHRDLSARNILVGEHFEMKIADFGLTRIVDYYYR 719
Query: 600 -ETPDY--TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRILR 656
+T +W + E L + +Y K+DVWS+G+L+WE+ TLG +PYS + V I +
Sbjct: 720 KKTDGILPVKWMAPEALLEKKYTTKSDVWSYGILLWEIFTLGDSPYSAILPEKVVDLIRK 779
Query: 657 GMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLV 692
G + +P E++++ CW + + RP F +V
Sbjct: 780 GFQNPKPELANFEIYRLMQHCWSLSSENRPNFFEIV 815
>UniRef50_Q06187 Cluster: Tyrosine-protein kinase BTK; n=54;
Gnathostomata|Rep: Tyrosine-protein kinase BTK - Homo
sapiens (Human)
Length = 659
Score = 129 bits (311), Expect = 3e-28
Identities = 62/217 (28%), Positives = 116/217 (53%), Gaps = 15/217 (6%)
Query: 482 QMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNKFC 541
+ ++E +++ S HE ++ L G+C + ++ E + LL+ R++++
Sbjct: 441 EFIEEAKVMMNLS-HEKLVQLYGVCTKQRPIFIITE----YMANGCLLNYLREMRHR--- 492
Query: 542 SITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSLHET 601
++L++C V MEYL +++ +H+ L RN ++++ G VK++ FGLS E
Sbjct: 493 -FQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEY 551
Query: 602 PDYT------RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRIL 655
RW+ E+L ++++ K+D+W+FGVLMWE+ +LG PY N + I
Sbjct: 552 TSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIA 611
Query: 656 RGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLV 692
+G+R +P ++++ + CW DERPTF L+
Sbjct: 612 QGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILL 648
>UniRef50_Q2VXS7 Cluster: Proto-oncogene c-fes variant 4; n=77;
Eutheria|Rep: Proto-oncogene c-fes variant 4 - Homo
sapiens (Human)
Length = 752
Score = 128 bits (310), Expect = 4e-28
Identities = 71/223 (31%), Positives = 120/223 (53%), Gaps = 16/223 (7%)
Query: 480 KKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNK 539
K + LQE +L K H N++ LIG+C + +V+E ++ + L R +
Sbjct: 531 KAKFLQEARIL-KQYSHPNIVRLIGVCTQKQPIYIVMELVQGG--DFLTFLRTEGAR--- 584
Query: 540 FCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRS-- 597
+ +LQ+ A GMEYL ++ +H+ L RN +++E +KI+ FG+S +
Sbjct: 585 ---LRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADG 641
Query: 598 LHETPDYTR-----WTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGS 652
++ +R WT+ E L RY+ ++DVWSFG+L+WE +LGA+PY + N+
Sbjct: 642 VYAASGGSRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTRE 701
Query: 653 RILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIEL 695
+ +G R P D +F++ QCW +P +RP+FS++ EL
Sbjct: 702 FVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQEL 744
>UniRef50_O73798 Cluster: Insulin-like growth factor 1 receptor
precursor (EC 2.7.10.1) (xIGF- 1R) (xIGFR) [Contains:
Insulin-like growth factor 1 receptor alpha chain;
Insulin-like growth factor 1 receptor beta chain]; n=25;
Euteleostomi|Rep: Insulin-like growth factor 1 receptor
precursor (EC 2.7.10.1) (xIGF- 1R) (xIGFR) [Contains:
Insulin-like growth factor 1 receptor alpha chain;
Insulin-like growth factor 1 receptor beta chain] -
Xenopus laevis (African clawed frog)
Length = 1358
Score = 128 bits (310), Expect = 4e-28
Identities = 74/241 (30%), Positives = 127/241 (52%), Gaps = 14/241 (5%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNN 538
E+ + L E ++ + + H +V+ L+G+ LV++E + + + L S + D ++N
Sbjct: 1039 ERIEFLNEASVMKEFNCH-HVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPDTESN 1097
Query: 539 KFCSITE-NKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRS 597
K++Q+ ++A GM YL+ K VH+ L RN +++E+ TVKI FG++ R
Sbjct: 1098 SGQPTPSLKKMIQMAGEIADGMSYLNANKFVHRDLAARNCMVTEDFTVKIGDFGMT--RD 1155
Query: 598 LHETPDY---------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNK 648
++ET Y RW S E L+ + +DVWSFGV++WE+ TL PY N+
Sbjct: 1156 IYETDYYRKGGKGLLPVRWMSPESLKDGVFTTNSDVWSFGVVLWEIATLAEQPYQGMSNE 1215
Query: 649 DVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEAPGTRNLS 708
V ++ G +P D LF++ CWQ +P RP+F ++ + + PG + +S
Sbjct: 1216 QVLRFVMEGGLLEKPDNCPDMLFELMRMCWQFNPKMRPSFLEIISSIKDELD-PGFKEVS 1274
Query: 709 F 709
F
Sbjct: 1275 F 1275
>UniRef50_Q4H2M8 Cluster: Tyrosine-protein kinase receptor; n=1;
Ciona intestinalis|Rep: Tyrosine-protein kinase receptor
- Ciona intestinalis (Transparent sea squirt)
Length = 817
Score = 128 bits (309), Expect = 5e-28
Identities = 62/165 (37%), Positives = 101/165 (61%), Gaps = 13/165 (7%)
Query: 543 ITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSLHETP 602
+T +L +QVARGME+L ++K +H+ L RN+++S+ VKI FGL+ R +++ P
Sbjct: 518 LTLTDLLSYSLQVARGMEFLASKKCIHRDLAARNVLLSDYQVVKICDFGLA--RDIYKDP 575
Query: 603 DYTR----------WTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPY-SHSGNKDVG 651
DY R W + E + Y+ K+DVWSFGVL+WE+ TLG +PY ++D
Sbjct: 576 DYVRSGGDARLPIKWMAPESIFDKVYSNKSDVWSFGVLLWEIFTLGGSPYPGLQMDEDFC 635
Query: 652 SRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELT 696
+++ RG+R +P + D ++ L CW +P++RPTF+ L E++
Sbjct: 636 NKLRRGVRMGKPEHATDSVYSAMLGCWDNNPEDRPTFTKLCEEIS 680
>UniRef50_P07949 Cluster: Proto-oncogene tyrosine-protein kinase
receptor ret precursor; n=59; Eumetazoa|Rep:
Proto-oncogene tyrosine-protein kinase receptor ret
precursor - Homo sapiens (Human)
Length = 1114
Score = 128 bits (309), Expect = 5e-28
Identities = 91/336 (27%), Positives = 161/336 (47%), Gaps = 34/336 (10%)
Query: 387 QRGSQSMPLSLSEPCVEIENSGFILEDEERVDYYGNLKRKLWNIPR-NLIETDISCVVGV 445
+R +Q+ P+S S S +E++ VD + L+ W PR NL+ + +G
Sbjct: 677 RRPAQAFPVSYSSSGAR-RPSLDSMENQVSVDAFKILEDPKWEFPRKNLV---LGKTLGE 732
Query: 446 GTYXXXXXXXXXXXXXXXXXXXXXIA--DRELEKTEKKQMLQELDLLIKTSEHENVISLI 503
G + + +E + +L E ++L K H +VI L
Sbjct: 733 GEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVL-KQVNHPHVIKLY 791
Query: 504 GICETNTTLLVVLEDIKK-TLKEMLLLSRQ--------------RDIQNNKFCSITENKV 548
G C + LL+++E K +L+ L SR+ + + ++T +
Sbjct: 792 GACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDL 851
Query: 549 LQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSLHETPDYTR-- 606
+ Q+++GM+YL K+VH+ L RN++++E +KI+ FGLS R ++E Y +
Sbjct: 852 ISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLS--RDVYEEDSYVKRS 909
Query: 607 -------WTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRILRGMR 659
W + E L Y ++DVWSFGVL+WE++TLG PY + + + + G R
Sbjct: 910 QGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHR 969
Query: 660 PSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIEL 695
+P +E++++ LQCW+ +PD+RP F+ + +L
Sbjct: 970 MERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDL 1005
>UniRef50_Q95YM9 Cluster: Fibroblast growth factor receptor
precursor; n=4; Ascidiacea|Rep: Fibroblast growth factor
receptor precursor - Halocynthia roretzi (Sea squirt)
Length = 763
Score = 128 bits (309), Expect = 5e-28
Identities = 71/238 (29%), Positives = 126/238 (52%), Gaps = 25/238 (10%)
Query: 483 MLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKK-TLKEMLLLSRQRDIQNNKFC 541
+L E+D + + +H+N+I+L+G+C N L +V+E + L++ L +R ++ N
Sbjct: 431 LLTEMDQMKRVGKHKNIINLLGVCTQNGPLWLVIEYAAQGNLRDYLRRNRPQNTLCNLVL 490
Query: 542 -----------------SITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGT 584
++T+ ++ QVARG+E+L +K +H+ L RN++++E
Sbjct: 491 PSEGRNPDDELPVPHGDTLTQKDIVSFAFQVARGLEFLAQKKCIHRDLAARNVLVTEELV 550
Query: 585 VKIAGFGLSH-LRSLHETPDYTR------WTSHEMLRQTRYNPKADVWSFGVLMWEVLTL 637
+KIA FGL+ +RS +TR W + E + + DVWSFGVL+WE+ +L
Sbjct: 551 MKIADFGLARDIRSCDYYRKHTRGHLPYKWMALEAMSDNIFTHATDVWSFGVLLWEIFSL 610
Query: 638 GATPYSHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIEL 695
+PY ++ + G R +P Y E++++ CW+ DP +RP F +LV +L
Sbjct: 611 AGSPYPGIKTHELVKFLRSGERLDKPQYASQEMYRLMRDCWEEDPSKRPNFRTLVEDL 668
>UniRef50_Q9U8U8 Cluster: VEGFR-like; n=1; Branchiostoma
belcheri|Rep: VEGFR-like - Branchiostoma belcheri
(Amphioxus)
Length = 445
Score = 128 bits (308), Expect = 7e-28
Identities = 60/169 (35%), Positives = 101/169 (59%), Gaps = 12/169 (7%)
Query: 543 ITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSLHETP 602
+T ++ QVARGM+YL ++K +H+ L RN++++++ VKI FGL+ R ++ P
Sbjct: 138 LTLEDLVSYSYQVARGMDYLASKKCIHRDLAARNVLLAKHNVVKICDFGLA--RDVYRNP 195
Query: 603 DY---------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSG-NKDVGS 652
+Y +W + E + Y ++DVWS+GVL+WE+ LG +PY N+D
Sbjct: 196 EYIKMGNAPLPVKWMAPESIFDRSYTIQSDVWSYGVLLWEIFELGGSPYPGVQINEDFFD 255
Query: 653 RILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEA 701
++ +G R QP + D+L+Q+ L CW+++P ERPTF+ L ++ EA
Sbjct: 256 KLRQGFRMRQPKHASDDLYQMMLSCWRMEPTERPTFTDLAESMSSQLEA 304
Score = 36.7 bits (81), Expect = 2.2
Identities = 15/47 (31%), Positives = 27/47 (57%)
Query: 474 ELEKTEKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIK 520
+ E K ++ EL +LI +H N+++L+G C + L V++E K
Sbjct: 27 DASSNEVKALMDELKILIHIGQHLNIVNLLGACTKDGPLYVIVECCK 73
>UniRef50_P00522 Cluster: Tyrosine-protein kinase Abl; n=5;
Eumetazoa|Rep: Tyrosine-protein kinase Abl - Drosophila
melanogaster (Fruit fly)
Length = 1620
Score = 128 bits (308), Expect = 7e-28
Identities = 69/217 (31%), Positives = 114/217 (52%), Gaps = 14/217 (6%)
Query: 481 KQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNKF 540
K L+E ++ K +H N++ LIG+C ++ E + L S R+
Sbjct: 410 KDFLEEAAIM-KEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRE------ 462
Query: 541 CSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLR---- 596
++ +L + Q+A GM YL +R +H+ L RN ++ +N VK+A FGL+ L
Sbjct: 463 -TLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMRDDT 521
Query: 597 -SLHETPDYT-RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRI 654
+ H + +WT+ E L +++ K+DVW+FGVL+WE+ T G +PY DV ++
Sbjct: 522 YTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKL 581
Query: 655 LRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSL 691
+G R +P E++ + QCWQ D +RPTF S+
Sbjct: 582 DKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSI 618
>UniRef50_Q7YSY1 Cluster: Fes-like tyrosine kinase protein; n=1;
Schistosoma mansoni|Rep: Fes-like tyrosine kinase protein
- Schistosoma mansoni (Blood fluke)
Length = 1259
Score = 127 bits (307), Expect = 9e-28
Identities = 70/205 (34%), Positives = 108/205 (52%), Gaps = 13/205 (6%)
Query: 496 HENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNKFCSITENKVLQICVQV 555
H N++ L+GI + +++V+E + LL+ R +N ++ K+LQ+ +
Sbjct: 1015 HPNIVKLVGIAVQSYPIMIVMEYVPGGS----LLNHLRKSKN----ALPVMKLLQMSLDA 1066
Query: 556 ARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSLHETPDYT-----RWTSH 610
A GM YL R +H+ L RN +IS++G +KIA FG+S ++E D +WT+
Sbjct: 1067 ANGMMYLEARNCIHRDLAARNCLISDDGQLKIADFGMSREEHIYELSDKRGQIPIKWTAP 1126
Query: 611 EMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRILRGMRPSQPSYVGDEL 670
E LR RY K DVWS+GVL+WE+ T G PY + N+ I G R P + L
Sbjct: 1127 EALRTGRYTIKCDVWSYGVLLWEIFTFGDVPYRNWSNQQTRDMIESGYRLPAPDLMPVWL 1186
Query: 671 FQVCLQCWQVDPDERPTFSSLVIEL 695
+ CW +P RP+FS + E+
Sbjct: 1187 RTLMNHCWHDEPMNRPSFSKISNEI 1211
>UniRef50_Q6NP28 Cluster: LP09923p; n=6; Endopterygota|Rep: LP09923p
- Drosophila melanogaster (Fruit fly)
Length = 847
Score = 127 bits (307), Expect = 9e-28
Identities = 69/214 (32%), Positives = 114/214 (53%), Gaps = 9/214 (4%)
Query: 490 LIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNKFCSITENKVL 549
++ T EH+N++ IG+ T+ L +V E + K L SR R IT+ +
Sbjct: 639 VMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQ-------HITKKDQI 691
Query: 550 QICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLR--SLHETPDYTRW 607
A GMEYL +K+VH+ L RN++ISE+ K++ FGL+ +L +W
Sbjct: 692 IFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLAREECYNLDVGKLPIKW 751
Query: 608 TSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRILRGMRPSQPSYVG 667
T+ E L+ R++ K+D+WSFG+L+WE+ + G PY DV + G + P
Sbjct: 752 TAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCP 811
Query: 668 DELFQVCLQCWQVDPDERPTFSSLVIELTPFSEA 701
E++++ Q W ++P +RPTF+ L ++L + A
Sbjct: 812 PEIYEMMRQAWDLNPAKRPTFAELKVKLQLLNNA 845
>UniRef50_P00533 Cluster: Epidermal growth factor receptor
precursor; n=124; root|Rep: Epidermal growth factor
receptor precursor - Homo sapiens (Human)
Length = 1210
Score = 127 bits (307), Expect = 9e-28
Identities = 75/243 (30%), Positives = 127/243 (52%), Gaps = 19/243 (7%)
Query: 470 IADREL-EKTEKKQMLQELD--LLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEM 526
+A +EL E T K + LD ++ + ++ +V L+GIC T+T L+ + +
Sbjct: 742 VAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIT-----QLMPFG 796
Query: 527 LLLSRQRDIQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVK 586
LL R+ ++N I +L CVQ+A+GM YL R++VH+ L RN+++ VK
Sbjct: 797 CLLDYVREHKDN----IGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVK 852
Query: 587 IAGFGLSHLRSLHETPDYT-------RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGA 639
I FGL+ L E + +W + E + Y ++DVWS+GV +WE++T G+
Sbjct: 853 ITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGS 912
Query: 640 TPYSHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFS 699
PY ++ S + +G R QP +++ + ++CW +D D RP F L+IE + +
Sbjct: 913 KPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMA 972
Query: 700 EAP 702
P
Sbjct: 973 RDP 975
>UniRef50_Q7QAK4 Cluster: ENSANGP00000020257; n=1; Anopheles gambiae
str. PEST|Rep: ENSANGP00000020257 - Anopheles gambiae
str. PEST
Length = 1192
Score = 127 bits (306), Expect = 1e-27
Identities = 67/224 (29%), Positives = 116/224 (51%), Gaps = 18/224 (8%)
Query: 475 LEKTEKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRD 534
L + +K++ LQE ++K +H N++ LIGIC +++V+E + +L+ R+
Sbjct: 967 LPEEQKRKFLQE-GRILKQYDHPNIVKLIGICVQKQPIMIVMELVAGG--SLLMFLRKNA 1023
Query: 535 IQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSH 594
++ + +++ +C A GM YL ++ +H+ L RN +I VKI+ FG+S
Sbjct: 1024 ------STLGQRQMMGMCRDAAAGMRYLESKNCIHRDLAARNCLIGSENIVKISDFGMSR 1077
Query: 595 LRS-------LHETPDYTRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGN 647
+ + P +WT+ E L +Y DVWS+G+L+WE+ + G TPYS N
Sbjct: 1078 EEEEYIVSGGMKQIP--IKWTAPEALNFGKYTSLCDVWSYGILVWEIFSRGDTPYSGMSN 1135
Query: 648 KDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSL 691
RI G R P E++++ L+CW +P+ RP F +
Sbjct: 1136 SMARERIDEGYRMPAPEGAPPEMYRLMLKCWSYEPESRPHFDEI 1179
>UniRef50_Q8NFA8 Cluster: Transmembrane receptor PTK7-2; n=18;
Euteleostomi|Rep: Transmembrane receptor PTK7-2 - Homo
sapiens (Human)
Length = 1030
Score = 127 bits (306), Expect = 1e-27
Identities = 77/236 (32%), Positives = 128/236 (54%), Gaps = 17/236 (7%)
Query: 473 RELEKTEKKQML---QELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKK-TLKEMLL 528
+ L+ +++Q L +EL++ K + H NV+ L+G+C +VLE + LK+ L
Sbjct: 790 KSLQSKDEQQQLDFRRELEMFGKLN-HANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLR 848
Query: 529 LSRQRDIQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIA 588
+S+ +D + T+ KV +C QVA GME+L + VHK L RN ++S VK++
Sbjct: 849 ISKSKDEKLKSQPLSTKQKVA-LCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVS 907
Query: 589 GFGLSHLRSLHETPDY--------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGAT 640
GLS + ++ + Y RW S E + + ++ K+DVW+FGVLMWEV T G
Sbjct: 908 ALGLS--KDVYNSEYYHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEM 965
Query: 641 PYSHSGNKDVGSRILRG-MRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIEL 695
P+ + +V + + G R QP +L+++ +CW + P +RP+FS + L
Sbjct: 966 PHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1021
>UniRef50_Q13308 Cluster: Tyrosine-protein kinase-like 7 precursor;
n=29; Tetrapoda|Rep: Tyrosine-protein kinase-like 7
precursor - Homo sapiens (Human)
Length = 1070
Score = 127 bits (306), Expect = 1e-27
Identities = 77/236 (32%), Positives = 128/236 (54%), Gaps = 17/236 (7%)
Query: 473 RELEKTEKKQML---QELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKK-TLKEMLL 528
+ L+ +++Q L +EL++ K + H NV+ L+G+C +VLE + LK+ L
Sbjct: 830 KSLQSKDEQQQLDFRRELEMFGKLN-HANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLR 888
Query: 529 LSRQRDIQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIA 588
+S+ +D + T+ KV +C QVA GME+L + VHK L RN ++S VK++
Sbjct: 889 ISKSKDEKLKSQPLSTKQKVA-LCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVS 947
Query: 589 GFGLSHLRSLHETPDY--------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGAT 640
GLS + ++ + Y RW S E + + ++ K+DVW+FGVLMWEV T G
Sbjct: 948 ALGLS--KDVYNSEYYHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEM 1005
Query: 641 PYSHSGNKDVGSRILRG-MRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIEL 695
P+ + +V + + G R QP +L+++ +CW + P +RP+FS + L
Sbjct: 1006 PHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1061
>UniRef50_Q07407 Cluster: Fibroblast growth factor receptor homolog
1 precursor; n=3; Sophophora|Rep: Fibroblast growth
factor receptor homolog 1 precursor - Drosophila
melanogaster (Fruit fly)
Length = 729
Score = 127 bits (306), Expect = 1e-27
Identities = 69/231 (29%), Positives = 129/231 (55%), Gaps = 23/231 (9%)
Query: 483 MLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKK-TLKEMLLLSRQRDIQNNKFC 541
+++E++++ H N+I+L+G C N L V++E LK+ L +R ++
Sbjct: 457 LVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDS 516
Query: 542 S----------ITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFG 591
S ITE +++ Q+ARGM+YL +R+ +H+ L RN+++S++ +KIA FG
Sbjct: 517 SQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFG 576
Query: 592 LSHLRSLHETPDY---------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPY 642
L+ R + T Y +W + E L++ Y+ K+DVWS+G+L+WE++T G PY
Sbjct: 577 LA--RDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPY 634
Query: 643 -SHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLV 692
+ +++ + ++ G R +P+ ++ + QCW + D+RP F+ +V
Sbjct: 635 PTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIV 685
>UniRef50_Q8IQ00 Cluster: CG3277-PB, isoform B; n=3; Sophophora|Rep:
CG3277-PB, isoform B - Drosophila melanogaster (Fruit
fly)
Length = 808
Score = 126 bits (305), Expect = 2e-27
Identities = 64/182 (35%), Positives = 107/182 (58%), Gaps = 5/182 (2%)
Query: 521 KTLKEMLLLSRQRDIQN-NKFCSITENKVLQ-ICVQVARGMEYLHTRKIVHKKLCCRNMI 578
K++ E L+ + +++ + F I +NK L +Q+A GM +L ++I H+ L RN++
Sbjct: 603 KSVNENLISATYTIVEDEDAFEYILDNKELHNFALQIANGMRFLEEQEITHRDLAARNVL 662
Query: 579 ISENGTVKIAGFGLSHLRSLHETPDYT---RWTSHEMLRQTRYNPKADVWSFGVLMWEVL 635
I N T+KI+ FGLS T RW S E +R+ Y+ K+D+W++GV++WE+
Sbjct: 663 IDSNKTLKISDFGLSRHGIYTNTRTRKLPLRWLSIEAIRENVYSSKSDIWAYGVVLWEIG 722
Query: 636 TLGATPYSHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIEL 695
TLGA+PY N ++ ++ G R +P +++ + LQCW +P+ERPTF +L L
Sbjct: 723 TLGASPYPTISNDELIPFLMAGNRLERPEICTPQVYTIMLQCWLEEPEERPTFDALYKVL 782
Query: 696 TP 697
+P
Sbjct: 783 SP 784
>UniRef50_P35968 Cluster: Vascular endothelial growth factor receptor
2 precursor; n=49; Bilateria|Rep: Vascular endothelial
growth factor receptor 2 precursor - Homo sapiens (Human)
Length = 1356
Score = 126 bits (305), Expect = 2e-27
Identities = 63/152 (41%), Positives = 91/152 (59%), Gaps = 12/152 (7%)
Query: 554 QVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSLHETPDYTR------- 606
QVA+GME+L +RK +H+ L RN+++SE VKI FGL+ R +++ PDY R
Sbjct: 1011 QVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLA--RDIYKDPDYVRKGDARLP 1068
Query: 607 --WTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPY-SHSGNKDVGSRILRGMRPSQP 663
W + E + Y ++DVWSFGVL+WE+ +LGA+PY +++ R+ G R P
Sbjct: 1069 LKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAP 1128
Query: 664 SYVGDELFQVCLQCWQVDPDERPTFSSLVIEL 695
Y E++Q L CW +P +RPTFS LV L
Sbjct: 1129 DYTTPEMYQTMLDCWHGEPSQRPTFSELVEHL 1160
>UniRef50_Q12866 Cluster: Proto-oncogene tyrosine-protein kinase MER
precursor; n=30; root|Rep: Proto-oncogene
tyrosine-protein kinase MER precursor - Homo sapiens
(Human)
Length = 999
Score = 126 bits (305), Expect = 2e-27
Identities = 81/230 (35%), Positives = 117/230 (50%), Gaps = 18/230 (7%)
Query: 491 IKTSEHENVISLIGICETNTTL-----LVVLEDIKK-TLKEMLLLSRQRDIQNNKFCSIT 544
+K H NVI L+G+C ++ +V+L +K L LL SR + I
Sbjct: 641 MKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKH----IP 696
Query: 545 ENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLS-------HLRS 597
+L+ V +A GMEYL R +H+ L RN ++ ++ TV +A FGLS + R
Sbjct: 697 LQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQ 756
Query: 598 LHETPDYTRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRILRG 657
+W + E L Y K+DVW+FGV MWE+ T G TPY N ++ +L G
Sbjct: 757 GRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIRTRGMTPYPGVQNHEMYDYLLHG 816
Query: 658 MRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEA-PGTRN 706
R QP DEL+++ CW+ DP +RPTFS L ++L E+ P RN
Sbjct: 817 HRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLPDVRN 866
>UniRef50_Q4SJQ3 Cluster: Tyrosine-protein kinase receptor; n=1;
Tetraodon nigroviridis|Rep: Tyrosine-protein kinase
receptor - Tetraodon nigroviridis (Green puffer)
Length = 1387
Score = 126 bits (304), Expect = 2e-27
Identities = 62/149 (41%), Positives = 92/149 (61%), Gaps = 12/149 (8%)
Query: 554 QVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSLHETPDYTR------- 606
QVARGME+L +RK +H+ L RN+++SE+ VKI FGL+ R +++ PDY R
Sbjct: 1036 QVARGMEFLASRKCIHRDLAARNILLSESNIVKICDFGLA--RDIYKDPDYVRKGNARLP 1093
Query: 607 --WTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPY-SHSGNKDVGSRILRGMRPSQP 663
W + E + Y ++DVWSFGVL+WE+ +LGA+PY +++ +R+ G R P
Sbjct: 1094 LKWMAPESIFDKVYTSQSDVWSFGVLLWEIFSLGASPYPGVQIDEEFCNRLRDGFRMRAP 1153
Query: 664 SYVGDELFQVCLQCWQVDPDERPTFSSLV 692
E++ + L CWQ +P +RPTF SLV
Sbjct: 1154 DTASPEIYGIMLACWQAEPKDRPTFPSLV 1182
Score = 37.1 bits (82), Expect = 1.7
Identities = 18/44 (40%), Positives = 28/44 (63%), Gaps = 1/44 (2%)
Query: 478 TEKKQMLQELDLLIKTSEHENVISLIGIC-ETNTTLLVVLEDIK 520
+E K ++ EL +LI H NV++L+G C + N L+VV+E K
Sbjct: 901 SEHKALMSELKILIHIGNHLNVVNLLGACTKANGPLMVVVEYCK 944
>UniRef50_Q170Z1 Cluster: Tyrosine-protein kinase receptor; n=1; Aedes
aegypti|Rep: Tyrosine-protein kinase receptor - Aedes
aegypti (Yellowfever mosquito)
Length = 2073
Score = 126 bits (304), Expect = 2e-27
Identities = 73/223 (32%), Positives = 118/223 (52%), Gaps = 18/223 (8%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNN 538
EK + LQE L+ +H++++ LIG+C +L +V+E ++ L S + N
Sbjct: 1855 EKAEFLQEAHLM-SNFKHKHILKLIGVCLDLDSLYIVMELMQGGDLLSYLRSNRPTPGNP 1913
Query: 539 KFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISE----NGTVKIAGFGLSH 594
++ + ++ +CV VA G YL VH+ L CRN ++S VKI FGL+
Sbjct: 1914 SMLTLLD--LISMCVDVATGCRYLEEMHFVHRDLACRNCLVSSMDPRERVVKIGDFGLA- 1970
Query: 595 LRSLHETPDY---------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHS 645
R +++ Y RW S E L + ++D+W+FGVL+WE++TLG PY
Sbjct: 1971 -RDIYKNDYYRKEGEGLLPVRWMSPESLVDGVFTSQSDIWAFGVLLWEIMTLGQQPYPAR 2029
Query: 646 GNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTF 688
N +V + G R ++P +EL+Q+ L+CW P++RPTF
Sbjct: 2030 NNVEVLHYVRDGGRLTRPQDCPEELYQLMLKCWSYSPEDRPTF 2072
>UniRef50_Q26614 Cluster: Fibroblast growth factor receptor
precursor; n=4; Eumetazoa|Rep: Fibroblast growth factor
receptor precursor - Strongylocentrotus purpuratus
(Purple sea urchin)
Length = 972
Score = 126 bits (304), Expect = 2e-27
Identities = 68/232 (29%), Positives = 122/232 (52%), Gaps = 17/232 (7%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKK-TLKEMLLLSR-----Q 532
E ++ EL ++ ++ N+I+L+G C V++E L++ L R +
Sbjct: 683 EFSDLISELAMMKMIGKNPNIINLLGCCTQEGPPYVIVEFAHHGNLRDFLRSRRPPEEYE 742
Query: 533 RDIQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGL 592
+ I ++T ++ + QVARGM++L ++K +H+ L RN++++E+ +KI FGL
Sbjct: 743 KSILLTTSQTLTNKDLMSMAYQVARGMDFLASKKCIHRDLAARNVLVTEDFEMKICDFGL 802
Query: 593 SHLRSLHETPDY---------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYS 643
+ R +H Y +W + E L + ++DVWSFG+L+WE++TLG TPY
Sbjct: 803 A--RDIHYIDFYRKTTDGRLPVKWMAPEALFDRMFTTQSDVWSFGILLWEIMTLGGTPYP 860
Query: 644 HSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIEL 695
+ + + G R +P E++ + +CW+ P +RPTF LV +L
Sbjct: 861 SVPVEQMFDYLRSGKRLEKPQNTSLEIYHILCECWRTSPGQRPTFCELVEDL 912
>UniRef50_Q9XYS4 Cluster: Tyrosine kinase receptor HTK32; n=1; Hydra
vulgaris|Rep: Tyrosine kinase receptor HTK32 - Hydra
attenuata (Hydra) (Hydra vulgaris)
Length = 752
Score = 126 bits (303), Expect = 3e-27
Identities = 80/265 (30%), Positives = 131/265 (49%), Gaps = 19/265 (7%)
Query: 481 KQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLED------IKKTLKEMLLLSRQRD 534
+ ML EL ++ + S H NVISLIG C T+ L V+ E + + LL RQ +
Sbjct: 474 RDMLNELRMMRRVSRHPNVISLIGWCITDQNLYVLEEYAPFGCLLTFLRTQRLLRLRQEN 533
Query: 535 IQN-NKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLS 593
++ I E +L Q+A GM++L +IVH+ L CRN+ + KI+ +GL+
Sbjct: 534 LEELPSEDQIDEKTLLSFSWQIASGMKHLAGLQIVHRDLACRNIYLGHEKVCKISEYGLT 593
Query: 594 HLRSLHETPDY---------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSH 644
R ++ Y RW ++E + ++ Y K+DVWSFG+L+WE+++LG PY
Sbjct: 594 --RDIYAENVYRKNTGGQLPVRWMAYEAIFESLYTEKSDVWSFGILLWELISLGKIPYPE 651
Query: 645 SGNKDVGSRILR-GMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEAPG 703
+ +L G P ++ + + + CW P+ RP+FSSLV +L F
Sbjct: 652 IIRTEELLDVLESGYHMENPGHISTDFYLLMNSCWNKAPENRPSFSSLVKKLAEFMNDKD 711
Query: 704 TRNLSFTHYNGFEFEPHIPQYEVIS 728
+++ + E + + EV S
Sbjct: 712 EMHVNLNSFFKKELDNFLQDEEVSS 736
>UniRef50_Q9U5A8 Cluster: Insulin receptor-like protein precursor;
n=1; Bombyx mori|Rep: Insulin receptor-like protein
precursor - Bombyx mori (Silk moth)
Length = 1472
Score = 126 bits (303), Expect = 3e-27
Identities = 76/246 (30%), Positives = 127/246 (51%), Gaps = 17/246 (6%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNN 538
E+ + L E ++ K + +V+ L+G+ LVV+E +++ + L S + D + +
Sbjct: 1126 ERIEFLNEASVM-KAFDTFHVVRLLGVVSRGQPTLVVMELMERGDLKTYLRSMRPDAEGS 1184
Query: 539 KFCSI----TENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSH 594
S T +LQ+ +++A GM YL +K VH+ L RN +++ + TVK+ FG++
Sbjct: 1185 LPSSPPVPPTLQNILQMAIEIADGMAYLSAKKFVHRDLAARNCMVAGDLTVKVGDFGMT- 1243
Query: 595 LRSLHETPDY---------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHS 645
R ++ET Y RW S E L+ ++ +D WS+GV++WE+ TL PY
Sbjct: 1244 -RDIYETDYYRKGTKGLMPVRWMSPESLKDGVFSSSSDAWSYGVVLWEMATLAMQPYQGL 1302
Query: 646 GNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEAPGTR 705
N+ V ++ G +P D L+++ CW P RPTF LV +L P + P R
Sbjct: 1303 SNEQVLRYVVEGGVMERPEQCPDRLYELMRACWTHRPSARPTFLQLVADLVPHA-MPYFR 1361
Query: 706 NLSFTH 711
+ SF H
Sbjct: 1362 HRSFFH 1367
>UniRef50_O97191 Cluster: Tyrosine-protein kinase receptor; n=1;
Geodia cydonium|Rep: Tyrosine-protein kinase receptor -
Geodia cydonium (Sponge)
Length = 570
Score = 126 bits (303), Expect = 3e-27
Identities = 77/236 (32%), Positives = 121/236 (51%), Gaps = 14/236 (5%)
Query: 473 RELEKTEKKQMLQELDLLIKTSEHENVISLIGIC--ETNTTLLVVLEDIKKTLKEMLLLS 530
+++ + E + +L+ H NV+ L+G+C T+ L+VL + L+S
Sbjct: 306 KDISQQENIDNFVQESILMLGFNHPNVLELLGVCFDTTDRHPLIVLPFMANGDLRSYLMS 365
Query: 531 RQRDIQNNKFC----SITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVK 586
++ KF + E + L +C++VARGMEYL VH+ L RN ++S TV+
Sbjct: 366 KRDPSVTTKFTHFPQGLDEERALVMCLEVARGMEYLSNSSFVHRDLAARNCMVSGELTVR 425
Query: 587 IAGFGLS-------HLRSLHETPDYTRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGA 639
+A FGLS + R +T +W + E L + K+DVWSFGV+ WEV +L A
Sbjct: 426 VADFGLSRDVYSKDYYRMGTKTMLPVKWMAPESLADNIFTVKSDVWSFGVVCWEVFSLVA 485
Query: 640 TPYSHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIEL 695
PY GN ++ I G R P E++++ QCW + ++RP FS LV +L
Sbjct: 486 -PYPGIGNHEMSDYIGGGRRLKIPRLCPREIYELMEQCWNEESNKRPNFSELVSQL 540
>UniRef50_Q25177 Cluster: Receptor protein-tyrosine kinase; n=2;
Hydra vulgaris|Rep: Receptor protein-tyrosine kinase -
Hydra attenuata (Hydra) (Hydra vulgaris)
Length = 891
Score = 125 bits (302), Expect = 4e-27
Identities = 72/242 (29%), Positives = 123/242 (50%), Gaps = 24/242 (9%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLE--------DIKKTLKEMLLLS 530
E + + E+ +LI EH N+++L+G C + L ++E + + + L
Sbjct: 577 EYRDLSSEIKVLIHLGEHPNIVNLLGSCTKDGRLCAIMEYCPHGNLVGFLRPRRHVFSLQ 636
Query: 531 RQRDIQN--NKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIA 588
++ N FC + Q+A GM +L +K+VH+ L RN+++ + +K+A
Sbjct: 637 WEKQALNYDEDFCWLD---AATAAFQIASGMLFLSEKKLVHRDLAARNVLVGPDYIMKLA 693
Query: 589 GFGLSHLRSLHETPDY---------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGA 639
FGL+ R ++ + Y +W + E L Y K+DVWSFG+++WE+ T+G
Sbjct: 694 DFGLA--RDIYLSGVYIKESCGILPVKWMAPESLFDKVYTIKSDVWSFGIVLWEICTMGG 751
Query: 640 TPYSHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFS 699
+PY +D+ + G R QP DEL+++ LQCWQ P+ERP F +V +L
Sbjct: 752 SPYPGLPTEDLFEYLTAGKRMCQPVTCPDELYEIMLQCWQERPEERPWFHEIVSQLQRII 811
Query: 700 EA 701
E+
Sbjct: 812 ES 813
>UniRef50_Q70DV1 Cluster: Src tyrosine kinase; n=1; Schistosoma
mansoni|Rep: Src tyrosine kinase - Schistosoma mansoni
(Blood fluke)
Length = 647
Score = 125 bits (301), Expect = 5e-27
Identities = 73/235 (31%), Positives = 122/235 (51%), Gaps = 18/235 (7%)
Query: 491 IKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNKFCSITENKVLQ 550
+K H N+I L +C +V E + K LL+ + + N ++ ++
Sbjct: 393 MKRLHHPNLIQLYAVCTQTEPFYIVTEYMSKGS----LLNYLQSPEGN---ALNMQCLIM 445
Query: 551 ICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSLHETPDYT----- 605
+ ++A GM YL +R+ +H+ L RN+++ E VKIA FGL+ + E +
Sbjct: 446 MAAKIAPGMAYLESRRHIHRDLAARNVLVGEQHAVKIADFGLARMIHNREYVAHAGARFP 505
Query: 606 -RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRILRGMRPSQPS 664
+WTS E +R+ K+DVWSFG+L+ E++T G +PY N +V ++ G R S+P
Sbjct: 506 IKWTSPEAANYSRFTIKSDVWSFGILLTEIVTYGRSPYPGMHNAEVLRQVDAGYRMSKPP 565
Query: 665 YVGDELFQVCLQCWQVDPDERPTFSSLVIELTPF--SEAPGTRNLS---FTHYNG 714
EL+ + L+CW D ++RP+F+++ L F E P RN + +H NG
Sbjct: 566 GCPPELYDLMLECWAADENKRPSFATIHFRLEQFCEDEQPAYRNANTNIHSHPNG 620
>UniRef50_P00534 Cluster: Tyrosine-protein kinase transforming
protein erbB; n=8; root|Rep: Tyrosine-protein kinase
transforming protein erbB - Avian leukosis virus (ALV)
Length = 634
Score = 125 bits (301), Expect = 5e-27
Identities = 74/243 (30%), Positives = 126/243 (51%), Gaps = 19/243 (7%)
Query: 470 IADREL-EKTEKKQMLQELD--LLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEM 526
+A +EL E T K + LD ++ + ++ +V L+GIC T+T L+ + +
Sbjct: 162 VAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIT-----QLMPYG 216
Query: 527 LLLSRQRDIQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVK 586
LL R+ ++N I +L CVQ+A+GM YL R++VH+ L RN+++ VK
Sbjct: 217 CLLDYIREHKDN----IGSQYLLNWCVQIAKGMNYLEERRLVHRDLAARNVLVKTPQHVK 272
Query: 587 IAGFGLSHLRSLHETPDYT-------RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGA 639
I FGL+ L E + +W + E + Y ++DVWS+GV +WE++T G+
Sbjct: 273 ITDFGLAKLLGADEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGS 332
Query: 640 TPYSHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFS 699
PY ++ S + +G R QP +++ + ++CW +D D RP F L+ E + +
Sbjct: 333 KPYDGIPASEISSVLEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIAEFSKMA 392
Query: 700 EAP 702
P
Sbjct: 393 RDP 395
>UniRef50_Q5TUS8 Cluster: Tyrosine-protein kinase receptor; n=1;
Anopheles gambiae str. PEST|Rep: Tyrosine-protein kinase
receptor - Anopheles gambiae str. PEST
Length = 2075
Score = 124 bits (300), Expect = 6e-27
Identities = 69/223 (30%), Positives = 115/223 (51%), Gaps = 18/223 (8%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNN 538
EK++ LQE L+ +H+++ L+G+C LL+++E + + + L R R +
Sbjct: 1848 EKQEFLQEAQLM-SNFKHKHITRLLGVCLEADALLIIME-LMQGGDLLSYLRRSRSLPGQ 1905
Query: 539 KFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENG----TVKIAGFGLSH 594
+T ++ +C VA G YL VH+ L CRN ++S VKI FGL+
Sbjct: 1906 A-ARLTMLDLISMCQDVASGCRYLEEMHFVHRDLACRNCLVSSTDPRDRVVKIGDFGLA- 1963
Query: 595 LRSLHETPDY---------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHS 645
R +++ Y RW S E L + ++D+W+FGVL+WE++TLG PY
Sbjct: 1964 -RDIYKNDYYRKEGEGLLPVRWMSPESLVDGVFTSQSDIWAFGVLLWEIMTLGEQPYQAK 2022
Query: 646 GNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTF 688
N +V + + G +P +E++++ CW+ P+ERPTF
Sbjct: 2023 NNVEVLNHVREGGHLDRPKVCPNEMYELMKYCWKFSPEERPTF 2065
>UniRef50_Q5K4G5 Cluster: Receptor tyrosine kinase; n=1; Suberites
domuncula|Rep: Receptor tyrosine kinase - Suberites
domuncula (Sponge)
Length = 715
Score = 124 bits (300), Expect = 6e-27
Identities = 79/229 (34%), Positives = 125/229 (54%), Gaps = 10/229 (4%)
Query: 473 RELEKTE-KKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSR 531
+E TE +K ++ EL +L EH NV+S +G L +++E ++ L S+
Sbjct: 423 KESASTEDEKDIIMELKVLYHVGEHCNVVSFLGASVHKGKLHLIVEYCERGNLLQFLRSK 482
Query: 532 QRDIQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFG 591
+ D+++ S+ +N+V I QVA GM YL +++ +H+ L RN++I+++ T+K+A FG
Sbjct: 483 RGDMKSP--LSV-QNQVA-IASQVANGMAYLASKRCIHRDLAARNVLITKDLTLKVADFG 538
Query: 592 LSH-LRSLHETPDYTR----WTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSG 646
L+ + S P R W + E + K+DVWSFG+L+WE++TLG TPY
Sbjct: 539 LARKMYSSVYRPSGKRLPIKWMAPEGILDGVCTSKSDVWSFGILLWEIMTLGRTPYPGRS 598
Query: 647 NKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIEL 695
V I G R QP D+L+ V CWQ++P RP F+ L L
Sbjct: 599 AHWVIRDIENGYRMPQPDGCPDKLYSVMKCCWQMNPIARPEFTELTNSL 647
>UniRef50_UPI00015A7C25 Cluster: UPI00015A7C25 related cluster; n=3;
Danio rerio|Rep: UPI00015A7C25 UniRef100 entry - Danio
rerio
Length = 759
Score = 124 bits (299), Expect = 9e-27
Identities = 70/236 (29%), Positives = 118/236 (50%), Gaps = 25/236 (10%)
Query: 475 LEKTEKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRD 534
L K + L E ++K +H N++ LIG+C + +++E ++ L + +
Sbjct: 526 LPAEHKNKFLMEAARILKQYDHPNIVKLIGVCTQKQPIYIIMELVQGGDFLTFLRTEGHN 585
Query: 535 IQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSH 594
++++ + EN VA G+ YL ++K +H+ + RN ++ E VKI+ FG+S
Sbjct: 586 LKSSMLIRMAEN--------VASGLAYLESKKCIHRDVAARNCLVGEESVVKISDFGMSR 637
Query: 595 ---------LRSLHETPDYTRWTSHEMLR---QTRYNPKADVWSFGVLMWEVLTLGATPY 642
+ + P +WT+ E L RY ++DVWSFGVL+WE + G TPY
Sbjct: 638 EEQDGVYSATGGMKQIP--VKWTAPEALNYGSPGRYTTESDVWSFGVLLWETFSRGVTPY 695
Query: 643 ---SHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIEL 695
+ N+ + RG R P+ DE++ + QCWQ DP +RP+F L +L
Sbjct: 696 TIPTVMSNQQTRDEVERGYRMPAPNNCPDEIYTLMCQCWQYDPRKRPSFLKLKADL 751
>UniRef50_A7RVU0 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 337
Score = 124 bits (299), Expect = 9e-27
Identities = 70/235 (29%), Positives = 122/235 (51%), Gaps = 18/235 (7%)
Query: 477 KTEKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQ 536
+++ K + EL +LI EH+N+++++G C L+V++E L +R+ Q
Sbjct: 84 ESDYKDLASELKILIHLGEHKNIVNVLGACTRGRRLMVIIEFAPYGNLLSFLRARREVYQ 143
Query: 537 -------NNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAG 589
N+ + T + QV+RG+E+L +RK VH+ L RN+++ + +K++
Sbjct: 144 PTWTKTTNDPEKNYTLVDLTMASYQVSRGVEFLASRKCVHRDLAARNVLVGPDYVMKVSD 203
Query: 590 FGLSHLRSLHETPDYTR---------WTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGAT 640
FGL+ R +++ Y + W + E L Y K+DVWSFG+L+WE++TLG T
Sbjct: 204 FGLA--RDIYQDDLYVKNTSGLLPVKWMALESLFDRVYTEKSDVWSFGILLWEIMTLGGT 261
Query: 641 PYSHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIEL 695
PY + + + G R +QP E++ + CW P++RP F+ L L
Sbjct: 262 PYPGLPTEQLLDYLSEGQRMAQPQNCPLEIYTIMRDCWMQLPEQRPHFNVLADRL 316
>UniRef50_P00528 Cluster: Tyrosine-protein kinase Src64B; n=6;
Endopterygota|Rep: Tyrosine-protein kinase Src64B -
Drosophila melanogaster (Fruit fly)
Length = 552
Score = 124 bits (299), Expect = 9e-27
Identities = 71/216 (32%), Positives = 117/216 (54%), Gaps = 16/216 (7%)
Query: 484 LQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNKFCSI 543
LQE ++ K H +++L +C + +V E + K +L R+ D + F
Sbjct: 325 LQEAAIM-KKFRHNRLVALYAVCSQEEPIYIVQEYMSKG--SLLDFLREGDGRYLHF--- 378
Query: 544 TENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSLHE-TP 602
++ I QVA GMEYL +++++H+ L RN++I EN KI FGL+ + + E P
Sbjct: 379 --EDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVIADDEYCP 436
Query: 603 DY-----TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRILRG 657
+WT+ E + +++ K+DVWS+G+L+ E+ T G PY +++V I RG
Sbjct: 437 KQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERG 496
Query: 658 MRPSQPS--YVGDELFQVCLQCWQVDPDERPTFSSL 691
R +P+ Y D ++Q+ LQCW P++RPTF L
Sbjct: 497 FRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTFEFL 532
>UniRef50_UPI0000519AF4 Cluster: PREDICTED: similar to Abl tyrosine
kinase CG4032-PA; n=1; Apis mellifera|Rep: PREDICTED:
similar to Abl tyrosine kinase CG4032-PA - Apis
mellifera
Length = 1439
Score = 124 bits (298), Expect = 1e-26
Identities = 65/217 (29%), Positives = 114/217 (52%), Gaps = 14/217 (6%)
Query: 481 KQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNKF 540
K L+E ++ K +H N++ L+G+C ++ E + K LL R+ ++
Sbjct: 328 KDFLEEAAIM-KEMKHRNLVQLLGVCTREPPFYIITEFMSKGN----LLDYLRNESKHQI 382
Query: 541 CSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLR---- 596
++ ++ + Q+A GM YL +R +H+ L RN ++ EN VK+A FGL+ L
Sbjct: 383 NAVV---LMHMATQIASGMSYLESRNFIHRDLAARNCLVGENHLVKVADFGLARLMRDDT 439
Query: 597 -SLHETPDYT-RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRI 654
+ H + +WT+ E L +++ K+DVW+FG+L+WE+ T G +PY DV +
Sbjct: 440 YTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGILLWEIATYGMSPYPGVDLTDVYHML 499
Query: 655 LRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSL 691
+G R P +++++ QCWQ +RPTF +
Sbjct: 500 EKGYRMECPPGCPPKVYELMRQCWQWSAADRPTFKEI 536
>UniRef50_Q7YZH7 Cluster: MBRTK2; n=1; Monosiga brevicollis|Rep:
MBRTK2 - Monosiga brevicollis
Length = 759
Score = 124 bits (298), Expect = 1e-26
Identities = 74/229 (32%), Positives = 117/229 (51%), Gaps = 17/229 (7%)
Query: 480 KKQMLQELDLLIKTSEHENVISLIGIC--ETNTTLLVVLEDIKKTLKEMLLLSRQRDIQN 537
++ L E+ ++ + H N+I + G C + LLV L ++ L++ L R+
Sbjct: 404 RQDFLSEMTVMKEIGAHPNIIGIFGHCLRDEPHILLVELAELGN-LRDYL---RKCRTSQ 459
Query: 538 NKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRS 597
+K + ++ C+Q+A GM +L + ++H+ L RN+++S++ KI FGL+ RS
Sbjct: 460 SKPQLLGSRQLADFCLQIASGMSFLERKNVIHRDLAARNVLLSQSLACKICDFGLA--RS 517
Query: 598 LHETPDY--------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKD 649
+ E DY +W + E L Y K+DVWSFGV MWE+ +LG TPY N D
Sbjct: 518 I-ENEDYETTATKLPVKWMAPESLGYRIYTSKSDVWSFGVTMWEIFSLGGTPYVKHRNVD 576
Query: 650 VGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPF 698
+ S + G R +P + + CW + D RPTF LV LT F
Sbjct: 577 ILSLLADGYRLPKPRQAPGQADAIARMCWMHEADNRPTFLELVDLLTAF 625
>UniRef50_Q70W11 Cluster: Receptor tyrosine kinase X; n=1; Ciona
intestinalis|Rep: Receptor tyrosine kinase X - Ciona
intestinalis (Transparent sea squirt)
Length = 478
Score = 124 bits (298), Expect = 1e-26
Identities = 84/252 (33%), Positives = 127/252 (50%), Gaps = 22/252 (8%)
Query: 474 ELEKTEKKQMLQELDLLIKTSEHENVISLIGIC-ETNTTLLVVLEDIKKTLKEMLLLSRQ 532
++E TE + + L++ ENV++LIGI + + +VVL + LL
Sbjct: 187 KIEDTESVEKFLKEGLMMSDFHDENVLTLIGISWDDDGAPMVVLP----YMMHGDLLQFI 242
Query: 533 RDIQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGL 592
R NN T ++ +Q +GM YL +++ VH+ L RN +++E VK+A FGL
Sbjct: 243 RKPSNNP----TVKDLVGFGLQACKGMCYLASQRFVHRDLAARNCMLNETYVVKVADFGL 298
Query: 593 SHLRSLHETPDY----------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPY 642
+ R ++E Y +W + E L+Q + K DVWSFG+L+WE+LT G TPY
Sbjct: 299 A--RDIYEKEYYKPHEHAGRMPVKWMALESLQQQTFTIKTDVWSFGILLWELLTRGVTPY 356
Query: 643 SHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTP-FSEA 701
DV + IL G R QP Y D L+++ L CW P+ RP F +LV ++ + E
Sbjct: 357 PDVDAFDVVNYILDGRRLRQPQYCPDPLYELMLSCWHPLPETRPDFVTLVRKIEQIYGEI 416
Query: 702 PGTRNLSFTHYN 713
G YN
Sbjct: 417 HGVHYPGSQSYN 428
>UniRef50_A7SZN9 Cluster: Predicted protein; n=3; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 283
Score = 124 bits (298), Expect = 1e-26
Identities = 71/234 (30%), Positives = 120/234 (51%), Gaps = 11/234 (4%)
Query: 473 RELEKTEKKQMLQELDLLIKTSEHENVISLIGIC-ETNTTLLVVLEDIKK-TLKEMLLLS 530
R +++ K +L ELD++++ EH N+++LIG C + L+V++E L L +
Sbjct: 43 RTATESDWKDLLNELDIMVQVGEHPNIVNLIGACSDPEGPLMVIVEFCGNGNLLHYLQKN 102
Query: 531 RQRDIQN--NKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIA 588
++ N +I + L+I VA GM +L + VH+ L RN+++ E T K++
Sbjct: 103 SNKNYSNLHEYVLTIPARERLRIAADVASGMAHLEKMRCVHRDLAARNVLLDEALTAKVS 162
Query: 589 GFGLS---HLRSLHETPDY----TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATP 641
FGLS + S++E +W + E + Y +D WSFGVL+WE+ T G P
Sbjct: 163 DFGLSRDIYTNSVYEKTTGGKLPAKWMAIESIEAGLYTSHSDAWSFGVLLWEIETGGCIP 222
Query: 642 YSHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIEL 695
Y +++ + + +G R +P Y + L+ + L CW DP RP F + L
Sbjct: 223 YPTFTVQEMLNSLKKGYRLEKPPYCLEPLYTLMLSCWSADPALRPHFVEICARL 276
>UniRef50_A7S4Y9 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 277
Score = 124 bits (298), Expect = 1e-26
Identities = 68/225 (30%), Positives = 115/225 (51%), Gaps = 15/225 (6%)
Query: 480 KKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNK 539
++ +EL+ L+ EH NV+SL+G+C + ++ E +K + LLS +N
Sbjct: 52 REDFTRELESLVNM-EHSNVVSLLGVCRDSEPFYMIFECFEKGDLKQFLLS----CNDNG 106
Query: 540 FCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSLH 599
++T + L +C + GM YL K VHK L RN +++++ VKI LS+ L+
Sbjct: 107 RSTLTSSHKLTMCSNIVSGMSYLAANKFVHKDLAARNCMVTKDLQVKIGFLNLSY--DLY 164
Query: 600 ETPDYT--------RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVG 651
Y RW E + + K+DVWSFGVL WE+ +LG PY+ +++V
Sbjct: 165 NAEYYRFNNILIPLRWMPSEAIFHDDFTEKSDVWSFGVLAWEIYSLGQIPYTDRSDEEVL 224
Query: 652 SRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELT 696
+ +R +P D + V +CW+ +P++RP F + E++
Sbjct: 225 KCVKDDLRLPKPDNCPDNMANVMKKCWEPNPNDRPNFDMIFAEMS 269
>UniRef50_Q2VJ45 Cluster: HOOK3-RET fusion protein; n=3;
Eutheria|Rep: HOOK3-RET fusion protein - Homo sapiens
(Human)
Length = 776
Score = 124 bits (298), Expect = 1e-26
Identities = 74/242 (30%), Positives = 130/242 (53%), Gaps = 27/242 (11%)
Query: 478 TEKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKK-TLKEMLLLSRQ---- 532
+E + +L E ++L K H +VI L G C + LL+++E K +L+ L SR+
Sbjct: 429 SELRDLLSEFNVL-KQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPG 487
Query: 533 ----------RDIQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISEN 582
+ + ++T ++ Q+++GM+YL K+VH+ L RN++++E
Sbjct: 488 YLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEG 547
Query: 583 GTVKIAGFGLSHLRSLHETPDYTR---------WTSHEMLRQTRYNPKADVWSFGVLMWE 633
+KI+ FGLS R ++E Y + W + E L Y ++DVWSFGVL+WE
Sbjct: 548 RKMKISDFGLS--RDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWE 605
Query: 634 VLTLGATPYSHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVI 693
++TLG PY + + + + G R +P +E++++ LQCW+ +PD+RP F+ +
Sbjct: 606 IVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISK 665
Query: 694 EL 695
+L
Sbjct: 666 DL 667
>UniRef50_P30530 Cluster: Tyrosine-protein kinase receptor UFO
precursor; n=37; Euteleostomi|Rep: Tyrosine-protein
kinase receptor UFO precursor - Homo sapiens (Human)
Length = 887
Score = 124 bits (298), Expect = 1e-26
Identities = 75/229 (32%), Positives = 121/229 (52%), Gaps = 19/229 (8%)
Query: 477 KTEKKQMLQELDLLIKTSEHENVISLIGIC------ETNTTLLVVLEDIKK-TLKEMLLL 529
++E + L E + +K +H NV+ LIG+C E+ +V+L +K L LL
Sbjct: 569 RSELEDFLSEA-VCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLY 627
Query: 530 SRQRDIQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAG 589
SR D + + +++ +A GMEYL T++ +H+ L RN +++EN +V +A
Sbjct: 628 SRLGD----QPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVAD 683
Query: 590 FGLS-------HLRSLHETPDYTRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPY 642
FGLS + R +W + E L Y K+DVWSFGV MWE+ T G TPY
Sbjct: 684 FGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPY 743
Query: 643 SHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSL 691
N ++ + +G R QP+ D L+ + +CW+++P +RP+F+ L
Sbjct: 744 PGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTEL 792
Score = 35.9 bits (79), Expect = 3.9
Identities = 45/174 (25%), Positives = 73/174 (41%), Gaps = 19/174 (10%)
Query: 91 KNETQKCGGNNA----TSVYDTDVVAPGQPSNLVLFNATETTVRLRWSAPNAYSFITSYV 146
K + C +NA TS T V P QP NL L + T + + W+ + + ++
Sbjct: 192 KTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTELEVAWTPGLSGIYPLTHC 251
Query: 147 IRAAVIET--------YSDYNLKPLEWRVSNETLNMELLNLHPGSKYNISVAALNYDEEG 198
AV+ D +PL + S + L +LHP + Y+I VA + +G
Sbjct: 252 TLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLHPHTPYHIRVACTS--SQG 309
Query: 199 PNI---TMVTETVIGTPDPSPPDVEIIQRRGDRMVVHIPKAK-NVNGPVSMYRI 248
P+ + ET G P PP+ R G + VH + + + G + YR+
Sbjct: 310 PSSWTHWLPVETPEGVP-LGPPENISATRNGSQAFVHWQEPRAPLQGTLLGYRL 362
>UniRef50_UPI00015B4B0F Cluster: PREDICTED: similar to
proto-oncogene tyrosine-protein kinase abl1; n=1;
Nasonia vitripennis|Rep: PREDICTED: similar to
proto-oncogene tyrosine-protein kinase abl1 - Nasonia
vitripennis
Length = 1522
Score = 123 bits (297), Expect = 1e-26
Identities = 65/217 (29%), Positives = 114/217 (52%), Gaps = 14/217 (6%)
Query: 481 KQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNKF 540
K L+E ++ K +H N++ LIG+C ++ E + K LL R+ ++
Sbjct: 329 KDFLEEAAIM-KEMKHRNLVQLIGVCTREPPFYIITEFMSKGN----LLDYLRNESKHQI 383
Query: 541 CSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLR---- 596
++ ++ + Q+A GM YL +R +H+ L RN ++ E+ VK+A FGL+ L
Sbjct: 384 NAVV---LMHMATQIASGMSYLESRNFIHRDLAARNCLVGESHLVKVADFGLARLMRDDT 440
Query: 597 -SLHETPDYT-RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRI 654
+ H + +WT+ E L +++ K+DVW+FG+L+WE+ T G +PY DV +
Sbjct: 441 YTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGILLWEIATYGMSPYPGVDLTDVYHML 500
Query: 655 LRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSL 691
+G R P +++++ QCWQ +RPTF +
Sbjct: 501 EKGYRMECPPGCPPKVYELMRQCWQWSASDRPTFKEI 537
>UniRef50_A7SP77 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 293
Score = 123 bits (297), Expect = 1e-26
Identities = 77/235 (32%), Positives = 122/235 (51%), Gaps = 25/235 (10%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLE-----DIKKTLKEM---LLLS 530
E K +E L++ T +H NV SL+G+C L +VLE D+ + L++ +
Sbjct: 49 EIKDAFEEEALVLTTYDHPNVQSLLGVCVIGRPLCLVLEYSDRGDLNQFLRDCGCSHYII 108
Query: 531 RQR-----DIQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTV 585
R+R D +NK + + L I Q+A GMEYL +R +HK+LC ++ IIS+N V
Sbjct: 109 RERPSSAIDPDSNKLSHLDQ---LCIAKQIAAGMEYLASRGYIHKQLCTKSCIISKNMIV 165
Query: 586 KIAGFGLS---------HLRSLHETPDYTRWTSHEMLRQTRYNPKADVWSFGVLMWEVLT 636
KIA G+S HL ++ ++ RW E + ++ D+WS+G+++WEV +
Sbjct: 166 KIANLGVSDAGPNTSYYHLNTIQKSKYPVRWLPLETIHNGIFDDNTDIWSYGIMLWEVYS 225
Query: 637 LGATPYSHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSL 691
G TPY N++V S + G +P E++ + CW + P ERP F L
Sbjct: 226 YGMTPYYGMNNEEVISLVRDGDILPKPKECPREMYSLMQDCWSLVPHERPRFRYL 280
>UniRef50_Q7Z1L9 Cluster: Neurite outgrowth regulated kinase; n=1;
Aplysia californica|Rep: Neurite outgrowth regulated
kinase - Aplysia californica (California sea hare)
Length = 991
Score = 123 bits (296), Expect = 2e-26
Identities = 74/243 (30%), Positives = 126/243 (51%), Gaps = 27/243 (11%)
Query: 480 KKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLE-----DIKKTLKEMLL---LSR 531
K+ ++ E++L+ + H N++ LIG C + + +V+E +++ LK+ + + +
Sbjct: 624 KEDLVAEINLMKRIGSHPNIVCLIGACTMSEPIALVMEYVPYGNLQNFLKKCRMDGDVRK 683
Query: 532 QRD---------IQNNKFCS---ITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMII 579
+ D IQ+N +T +L QVA MEYL +K VH+ L RN++I
Sbjct: 684 RCDGPSEITYTVIQDNGSMESGVVTPVDMLSFARQVAMAMEYLAEKKYVHRDLAARNVLI 743
Query: 580 SENGTVKIAGFGLS-------HLRSLHETPDYTRWTSHEMLRQTRYNPKADVWSFGVLMW 632
N VK+ FGLS H + L +W + E LR + ++DVWSFG+L+W
Sbjct: 744 DYNKVVKVCDFGLSRDIFNDNHYKKLTNGKLPLKWMAIESLRDRMFTTQSDVWSFGILLW 803
Query: 633 EVLTLGATPYSHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLV 692
E++T+GA+PY + D+ + G R +PS EL+ + CW+ + +RP F+ L
Sbjct: 804 EIVTMGASPYPNVALADLYYVLSNGYRMDRPSNCSQELYAIMRACWEDESTDRPNFTQLR 863
Query: 693 IEL 695
+ L
Sbjct: 864 LML 866
>UniRef50_Q70W09 Cluster: Receptor tyrosine kinase VIII; n=1; Ciona
intestinalis|Rep: Receptor tyrosine kinase VIII - Ciona
intestinalis (Transparent sea squirt)
Length = 895
Score = 123 bits (296), Expect = 2e-26
Identities = 81/239 (33%), Positives = 121/239 (50%), Gaps = 18/239 (7%)
Query: 478 TEKKQMLQELDLLIKTSEHENVISLIGICETNTTL------LVVLEDIKKTLKEMLLLSR 531
TE + ++E L +K +H NV++LIGI T L LVVL + L S
Sbjct: 594 TEVEGFVKE-GLRMKDLDHPNVMALIGIAFTAEDLNKPASPLVVLPYMPNGDLRSYLFSM 652
Query: 532 QRDIQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFG 591
+ + KF T K+L + VA+GM+YL R +H+ L RN ++ EN V ++ FG
Sbjct: 653 RTAGLSEKF---TVQKLLLFALDVAKGMQYLSNRNFIHRDLAARNCMLDENYKVVVSDFG 709
Query: 592 LS-------HLRSLHETPDYTRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSH 644
LS + R H + +W + E L + P +DVWSFGV +WE+LT+G +PY
Sbjct: 710 LSRTVYSESYYRQTHISKMPVKWMALESLADNIFTPLSDVWSFGVTVWEILTMGQSPYPG 769
Query: 645 SGNKDVGSRILRGMRPSQPSYVGDEL-FQVCLQCWQVDPDERPTFSSLVIELTPFSEAP 702
GN +V + G R ++P + ++ F V CW V +R TF LV L+ + P
Sbjct: 770 VGNHEVYQLLRNGTRLNKPEHCPSKVWFSVVFPCWTVQVKDRITFDKLVEVLSEITCNP 828
>UniRef50_Q008W6 Cluster: Gamma-carboxyglutamic acid protein 1; n=2;
Ascidiacea|Rep: Gamma-carboxyglutamic acid protein 1 -
Ciona intestinalis (Transparent sea squirt)
Length = 556
Score = 123 bits (296), Expect = 2e-26
Identities = 75/233 (32%), Positives = 118/233 (50%), Gaps = 21/233 (9%)
Query: 473 RELEKTEKKQMLQELDLLIKTSEHENVISLIGIC------ETNTTLLVVLEDIKKTLKEM 526
+ LE E + ++++ +H NV++LIG+C T+ L++L ++
Sbjct: 207 KSLENHEDVEKFLREGVMMRGLDHRNVLALIGVCVDGEVERLQTSPLIILPFMENGDLRT 266
Query: 527 LLLSRQRDIQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVK 586
L RD N +T K+L+ C VA GMEYL +K VH+ L RN ++ +N VK
Sbjct: 267 FL----RDGNN----VLTVLKLLKFCKDVAMGMEYLAEKKFVHRDLAARNCMVDKNWCVK 318
Query: 587 IAGFGLS-------HLRSLHETPDYTRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGA 639
+A FGLS + RS +T +W E ++ RY K+DVWS+G++ WE++T GA
Sbjct: 319 VADFGLSRDLFDRDYYRSSVKTQLPLKWMPPESIKYGRYGEKSDVWSYGIVCWEIMTRGA 378
Query: 640 TPYSHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLV 692
PY + + G R +P +L++ +CW D + RPTF LV
Sbjct: 379 IPYPTVQAVAILQYLSEGNRMERPECCPHKLYKTMEKCWLDDTERRPTFEELV 431
>UniRef50_A7SAX2 Cluster: Predicted protein; n=3; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 315
Score = 123 bits (296), Expect = 2e-26
Identities = 71/235 (30%), Positives = 120/235 (51%), Gaps = 21/235 (8%)
Query: 476 EKTEKKQMLQELDLLIKTSEHENVISLIGIC-----ETNTTLLVVLEDIKKTLKEMLLLS 530
++ +K L EL+L+ H +V+ LIG C E + L ++ E + ++L
Sbjct: 69 QEKDKTDFLTELNLMKSLRPHPHVVRLIGCCTRQAGELSNHLAIIFEYLP--YGDLLGYL 126
Query: 531 RQRDIQNNKFCS--------ITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISEN 582
R+ + +CS + +++ +A GM +L K VH+ L RN+++ E+
Sbjct: 127 RRSRGHEDWYCSGDLRPPSRLVSKDLVKFAWMIADGMAFLAANKCVHRDLAARNVLVGEH 186
Query: 583 GTVKIAGFGLSH--LRSLHETPDYTR----WTSHEMLRQTRYNPKADVWSFGVLMWEVLT 636
T KI+ GL+ + ++ R W E L + + +DVWS+G+++WE+ T
Sbjct: 187 NTCKISDLGLARDVSQDIYTRTSSARLPVKWMPPESLLYGQSSSASDVWSYGIVLWEIFT 246
Query: 637 LGATPYSHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSL 691
+G +PY +K + + G R +P +VGD L+ V L+CWQ DPDERPTF L
Sbjct: 247 IGDSPYPGVKSKGIPRMLREGYRMPKPPHVGDALYFVMLRCWQEDPDERPTFDEL 301
>UniRef50_Q15303 Cluster: Receptor tyrosine-protein kinase erbB-4
precursor; n=58; Euteleostomi|Rep: Receptor
tyrosine-protein kinase erbB-4 precursor - Homo sapiens
(Human)
Length = 1308
Score = 123 bits (296), Expect = 2e-26
Identities = 69/237 (29%), Positives = 122/237 (51%), Gaps = 20/237 (8%)
Query: 476 EKTEKKQMLQELD--LLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQR 533
E T K ++ +D L++ + +H +++ L+G+C + T LV + + LL
Sbjct: 755 ETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVT-----QLMPHGCLLEYVH 809
Query: 534 DIQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLS 593
+ ++N I +L CVQ+A+GM YL R++VH+ L RN+++ VKI FGL+
Sbjct: 810 EHKDN----IGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLA 865
Query: 594 HLRSLHETPDYT--------RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHS 645
L E +Y +W + E + ++ ++DVWS+GV +WE++T G PY
Sbjct: 866 RLLEGDEK-EYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGI 924
Query: 646 GNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEAP 702
+++ + +G R QP +++ V ++CW +D D RP F L E + + P
Sbjct: 925 PTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDP 981
>UniRef50_Q4JDD5 Cluster: Tyrosine-protein kinase receptor; n=5; Danio
rerio|Rep: Tyrosine-protein kinase receptor - Danio rerio
(Zebrafish) (Brachydanio rerio)
Length = 1272
Score = 122 bits (295), Expect = 3e-26
Identities = 58/149 (38%), Positives = 93/149 (62%), Gaps = 12/149 (8%)
Query: 554 QVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSLHETPDYTR------- 606
QVARGME+L +RK +H+ L RN+++S N VKI FGL+ R L++ PDY R
Sbjct: 986 QVARGMEFLASRKCIHRDLAARNILLSNNNVVKICDFGLA--RDLYKDPDYVRNGDARLP 1043
Query: 607 --WTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPY-SHSGNKDVGSRILRGMRPSQP 663
W + E + + ++DVWS+GVL+WE+ +LGA+PY + +++ R+ G R P
Sbjct: 1044 LKWMAPESIFDKVFTTQSDVWSYGVLLWEIFSLGASPYPGLNMDEEFCRRLKHGTRMCSP 1103
Query: 664 SYVGDELFQVCLQCWQVDPDERPTFSSLV 692
Y E++ + CW+ +P++RP+F++LV
Sbjct: 1104 QYSTPEIYSIMCACWENNPEDRPSFTTLV 1132
>UniRef50_Q7YXV8 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 865
Score = 122 bits (295), Expect = 3e-26
Identities = 75/224 (33%), Positives = 115/224 (51%), Gaps = 22/224 (9%)
Query: 496 HENVISLIGIC---ETNTTLLVVLEDIKKTLKEMLL-----LSRQRDIQNNKFCSITENK 547
H N+I L G+C T L+V+ I LK L+ LS + DI N+ K
Sbjct: 647 HPNIIELFGMCFDAPDGTPLMVLPFMINGNLKSYLVKSRNPLSEKPDIFPNELGLAVMTK 706
Query: 548 VLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSLHETPDY--- 604
+ C +ARGM Y ++ VH+ L RN ++ + TVKI FGL+ R+++ T Y
Sbjct: 707 M---CTDIARGMSYFVDQRFVHRDLAARNCLLDHDLTVKIGDFGLA--RNVYMTGYYKAS 761
Query: 605 ------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRILRGM 658
+W + EMLR N K DVW++GV WEV +LG+TPY N V +++G
Sbjct: 762 TRAALPVKWMAPEMLRDGISNEKTDVWAYGVTCWEVFSLGSTPYPGVDNHLVLEHLMKGF 821
Query: 659 RPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEAP 702
R ++P ++ +Q+ +CW +P +RP FS ++ E+ P
Sbjct: 822 RLAKPFLCFEKNYQILQRCWSNNPGDRPCFSQILNEMEALVNVP 865
>UniRef50_P51813 Cluster: Cytoplasmic tyrosine-protein kinase BMX;
n=36; Euteleostomi|Rep: Cytoplasmic tyrosine-protein
kinase BMX - Homo sapiens (Human)
Length = 675
Score = 122 bits (295), Expect = 3e-26
Identities = 63/225 (28%), Positives = 112/225 (49%), Gaps = 15/225 (6%)
Query: 482 QMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNKFC 541
+ QE ++K S H ++ G+C + +V E I L S + ++
Sbjct: 456 EFFQEAQTMMKLS-HPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLE----- 509
Query: 542 SITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLR----- 596
+++L++C V GM +L + + +H+ L RN ++ + VK++ FG++
Sbjct: 510 ---PSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQY 566
Query: 597 -SLHETPDYTRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRIL 655
S T +W++ E+ +Y+ K+DVW+FG+LMWEV +LG PY N V ++
Sbjct: 567 VSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVS 626
Query: 656 RGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSE 700
+G R +P D ++Q+ CW P++RPTF L+ + P E
Sbjct: 627 QGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQQLLSSIEPLRE 671
>UniRef50_UPI0000D55B96 Cluster: PREDICTED: similar to
Tyrosine-protein kinase Src64B (Dsrc64) isoform 2; n=1;
Tribolium castaneum|Rep: PREDICTED: similar to
Tyrosine-protein kinase Src64B (Dsrc64) isoform 2 -
Tribolium castaneum
Length = 473
Score = 122 bits (294), Expect = 3e-26
Identities = 67/224 (29%), Positives = 119/224 (53%), Gaps = 15/224 (6%)
Query: 476 EKTEKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDI 535
E T Q + ++K H+ +++L G+C + + +V E + K +L R+ +
Sbjct: 237 EGTMSTQAFLQEAAIMKKFRHKRLVTLFGVCSEHEPIYIVQEYMSKG--SLLDFLRKDEG 294
Query: 536 QNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHL 595
+ +F ++ I QVA GMEYL +++++H+ L RN++I EN KI FGL+ +
Sbjct: 295 KELEF-----EDLVYIAFQVASGMEYLESKQLIHRDLAARNVLIGENNIAKICDFGLARV 349
Query: 596 RSLHE-TPDY-----TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKD 649
+E P +WT+ E + +++ K+DVWS+G+ + E+ T G PY ++
Sbjct: 350 IEDNEYCPKQGSRFPVKWTAPEAIVYGKFSIKSDVWSYGIFLMELFTYGQVPYPGMHGRE 409
Query: 650 VGSRILRGMRPSQPS--YVGDELFQVCLQCWQVDPDERPTFSSL 691
V + +G R +P+ + DE++ + LQCW P+ RPTF L
Sbjct: 410 VIDMVEKGYRMGKPTSHVLPDEIYSIMLQCWDAKPENRPTFEFL 453
>UniRef50_Q4RH14 Cluster: Chromosome undetermined SCAF15074, whole
genome shotgun sequence; n=1; Tetraodon
nigroviridis|Rep: Chromosome undetermined SCAF15074,
whole genome shotgun sequence - Tetraodon nigroviridis
(Green puffer)
Length = 654
Score = 122 bits (294), Expect = 3e-26
Identities = 73/228 (32%), Positives = 117/228 (51%), Gaps = 8/228 (3%)
Query: 483 MLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNKFCS 542
ML E L ++ H N++ + +C + +VL L L + + + N S
Sbjct: 425 MLTE-SLKLRGLHHRNLLPISHVCTEDGEKPMVLLPFVAWGNLKLFLRQCKLAEANNPQS 483
Query: 543 ITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSH------LR 596
+++ ++ + +Q+A GM YL R+++HK L RN +I ++ VKI+ L+
Sbjct: 484 VSQQDLVSMAIQIACGMSYLSRREVIHKDLAARNCVIDDSMQVKISDNALARDLFPMDYH 543
Query: 597 SLHETPDY-TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRIL 655
L + + RW + E L ++ +DVW+FGV +WE++TLG TPY ++ + +
Sbjct: 544 CLGDNENRPVRWMALESLLHNDFSSLSDVWAFGVTLWELMTLGQTPYVDIDPFEMSAYLK 603
Query: 656 RGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEAPG 703
G R +QP DELF V CW +DP+ERP F LV LT F A G
Sbjct: 604 DGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEFHSALG 651
>UniRef50_Q86MD7 Cluster: EGF receptor; n=1; Echinococcus
multilocularis|Rep: EGF receptor - Echinococcus
multilocularis
Length = 1564
Score = 122 bits (293), Expect = 5e-26
Identities = 68/240 (28%), Positives = 116/240 (48%), Gaps = 17/240 (7%)
Query: 472 DRELEKTEKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSR 531
DR ++ + ML E ++ +H+N + LIG+C T +V +++ + L
Sbjct: 1051 DRISARSNLQDMLTEAKVMASV-QHKNCLPLIGVCLTRKMQCMVSMFVEEGSLDRYLRLH 1109
Query: 532 QRDIQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFG 591
+ D+ + S E Q+A GM YL R I+H+ L RN+++ V+I FG
Sbjct: 1110 RDDLNSFTLLSWAE--------QIADGMAYLEERGIIHRDLAARNVLVQSRELVQITDFG 1161
Query: 592 LSHLRSLHETPDYT--------RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYS 643
L+ + + RW + E L+ Y+ K DVWS+GV +WE+ T G PY
Sbjct: 1162 LAKMLDTNNEDSVVVRTGRVPIRWLAIETLQAGIYSHKTDVWSYGVTLWEIFTFGKQPYE 1221
Query: 644 HSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEAPG 703
+ ++ +++G+R SQP + + V +QCW + + RPTF L+ + + PG
Sbjct: 1222 NISTSEIKDHVMKGVRLSQPEICTLDTYMVMVQCWMEEHESRPTFLELMKCFHKYCQTPG 1281
>UniRef50_Q6R1Y3 Cluster: Src family kinase; n=6; Fungi/Metazoa
group|Rep: Src family kinase - Asterina miniata (Bat
star) (Patiria miniata)
Length = 563
Score = 122 bits (293), Expect = 5e-26
Identities = 68/223 (30%), Positives = 117/223 (52%), Gaps = 13/223 (5%)
Query: 484 LQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNKFCSI 543
LQE +++ K H +++L+ +C + +V E + LL + + + +
Sbjct: 343 LQEANIM-KKLRHPKLVALLAVCSEGEPIYIVTE----LMTNGCLLDYLHEGEGKQ---L 394
Query: 544 TENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLR-----SL 598
E +++ I QVA GM YL +++ VH+ L RN+++ + K+A FGLS + +
Sbjct: 395 REPELIDITAQVADGMAYLESQRFVHRDLAARNILVGDLRNCKVADFGLSRIIEDEYIAK 454
Query: 599 HETPDYTRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRILRGM 658
+WT+ E + ++ K+DVWSFG+L++EV+T G PY N++V ++ RG
Sbjct: 455 EGAKMPIKWTAPEAINFGKFTIKSDVWSFGILIYEVITKGRVPYPGMVNREVLDQVSRGY 514
Query: 659 RPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEA 701
R +P D+L+ + QCW P++RPTF L L F A
Sbjct: 515 RMPKPPECPDQLYDITKQCWDAVPEKRPTFEFLHSFLDDFYHA 557
>UniRef50_Q17MF5 Cluster: Tyrosine-protein kinase; n=2;
Culicidae|Rep: Tyrosine-protein kinase - Aedes aegypti
(Yellowfever mosquito)
Length = 747
Score = 122 bits (293), Expect = 5e-26
Identities = 65/206 (31%), Positives = 107/206 (51%), Gaps = 13/206 (6%)
Query: 490 LIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNKFCSITENKVL 549
++ T EHEN++ IG+ + + +V E + K L SR R IT +
Sbjct: 534 VMTTLEHENLVKFIGLVFHDKYIYLVTEYMSKGSLVDYLRSRGRQ-------HITRRDQI 586
Query: 550 QICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSLHETPDYTR--- 606
GMEYL +K++H+ L RN++ISE K++ FGL+ R T D ++
Sbjct: 587 NFAFDTCSGMEYLEMKKVIHRDLAARNVLISEECVAKVSDFGLA--RDERYTADISKLPI 644
Query: 607 -WTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRILRGMRPSQPSY 665
WT+ E L++ +++ K D+WSFG+L+WE+ + G PY DV + G + P
Sbjct: 645 KWTAPEALKEGKFSNKTDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVGSGYKMEAPEG 704
Query: 666 VGDELFQVCLQCWQVDPDERPTFSSL 691
E++++ Q W + P++RPTF+ L
Sbjct: 705 CPPEIYEMMRQAWDLVPEKRPTFAEL 730
>UniRef50_A7SE14 Cluster: Predicted protein; n=4; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 311
Score = 122 bits (293), Expect = 5e-26
Identities = 71/230 (30%), Positives = 122/230 (53%), Gaps = 19/230 (8%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKK-TLKEMLLLSRQR---- 533
E + +++E +LL + H +VI L+G E + LV++E + L L SR
Sbjct: 57 ETRDLMKEFELLKRLKSHPHVIKLLGCGEDDGRPLVIIEYVPHGDLLGYLRKSRGEEDSY 116
Query: 534 --DIQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFG 591
D + S++ ++++ QVA GM+YL ++KI+H+ L RN+++ E K+ FG
Sbjct: 117 YPDPEIKPKTSLSSQQLVRFAWQVADGMQYLSSQKIIHRDLAARNILVGEGEVCKVTDFG 176
Query: 592 LSHLRSLHETPDYTR---------WTSHE-MLRQTRYNPKADVWSFGVLMWEVLTLGATP 641
++ + + Y R WT+ E ++ Y ++DVWSFGV+++E+ T+G P
Sbjct: 177 MA--KDVQNEDIYIRTTEGRLPVKWTAIEALIGGGEYTTQSDVWSFGVVLYEICTIGGEP 234
Query: 642 YSHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSL 691
Y KD+ + G R S P+++ L+++ CW PD RPTF+SL
Sbjct: 235 YPGIAGKDIPEYLEAGYRMSCPTHLDATLYEIMASCWATCPDMRPTFTSL 284
>UniRef50_A7RNB2 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 236
Score = 122 bits (293), Expect = 5e-26
Identities = 71/235 (30%), Positives = 124/235 (52%), Gaps = 14/235 (5%)
Query: 474 ELEKTEKKQMLQ-ELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQ 532
E++ E+++ L EL ++ + H N++ LIG C LLVV E + +L R+
Sbjct: 1 EIDSDEEERKLHAELLIMQQIGNHPNIVKLIGACSVEKPLLVVTEYLSGG--NLLDHVRR 58
Query: 533 RDIQNNK-FCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFG 591
QN + +I+E+++L++ + V G+ ++ I+H L RN+++ + K+A FG
Sbjct: 59 MRAQNGLIYANISEHELLRLALGVCEGLVHIAECGIIHGDLAARNILLDSHANPKLADFG 118
Query: 592 LSHLRSLHET-----PDYTR-----WTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATP 641
S + D R W + E+L + K+DVWS+GV++WE+ TLG +P
Sbjct: 119 FSRDNKASKVLSSGKQDKQRKFPVKWMALELLHHNIFTRKSDVWSYGVVLWEIFTLGGSP 178
Query: 642 YSHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELT 696
Y ++ + R+L G R +P + DEL+ V L CW+ +P +R F + + LT
Sbjct: 179 YPGVPSRYLLKRLLTGYRMEKPLHCPDELYDVMLSCWEEEPIKRIGFPEVHLALT 233
>UniRef50_P04412 Cluster: Epidermal growth factor receptor precursor;
n=129; Endopterygota|Rep: Epidermal growth factor
receptor precursor - Drosophila melanogaster (Fruit fly)
Length = 1426
Score = 122 bits (293), Expect = 5e-26
Identities = 70/245 (28%), Positives = 121/245 (49%), Gaps = 21/245 (8%)
Query: 470 IADRELEKTEKKQMLQEL---DLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEM 526
+A +EL K+ + +E ++ + EH N++ L+ +C ++ +L+ ++
Sbjct: 968 VAIKELLKSTGAESSEEFLREAYIMASEEHVNLLKLLAVCMSSQMMLIT---------QL 1018
Query: 527 LLLSRQRDIQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVK 586
+ L D N I +L Q+A+GM YL +++VH+ L RN+++ VK
Sbjct: 1019 MPLGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVK 1078
Query: 587 IAGFGLSHLRSLHETPDYT--------RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLG 638
I FGL+ L S ++ +Y +W + E +R + K+DVW+FGV +WE+LT G
Sbjct: 1079 ITDFGLAKLLS-SDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFG 1137
Query: 639 ATPYSHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPF 698
P+ + KD+ I G++ QP +++ L CW +D RPTF L F
Sbjct: 1138 QRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEF 1197
Query: 699 SEAPG 703
+ PG
Sbjct: 1198 ARDPG 1202
>UniRef50_UPI0000E48358 Cluster: PREDICTED: hypothetical protein;
n=1; Strongylocentrotus purpuratus|Rep: PREDICTED:
hypothetical protein - Strongylocentrotus purpuratus
Length = 522
Score = 121 bits (292), Expect = 6e-26
Identities = 70/232 (30%), Positives = 116/232 (50%), Gaps = 9/232 (3%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNN 538
E++ +L + L++ H+N++ L+ +C ++ +LE K L R +
Sbjct: 290 EQRHLLVKESCLLQGLSHKNILPLLHVCFSDPPF--ILEAFMKLGNLKQFLKNGRIGPGD 347
Query: 539 KFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSH---- 594
K +I+ ++ + +Q+ GM YL +++VHK L RN +I E+ +KI LS
Sbjct: 348 KHQAISTRDLVHLAIQITHGMMYLGKKRLVHKDLATRNCVIDEDYNLKITDNALSRDLFP 407
Query: 595 --LRSLHETPDY-TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVG 651
L + + +W + E L +++ +DVWSFGV +WE++TLG TPY ++
Sbjct: 408 SDYHCLGDNENRPVKWMAVESLVHKKFSHASDVWSFGVTLWELVTLGQTPYMDLDPFEMA 467
Query: 652 SRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEAPG 703
+ + G R QP DELF + CW + P +RP FS L LT F G
Sbjct: 468 TFLKSGYRMPQPPSCPDELFNLMACCWALLPQDRPKFSQLCAALTDFHRTLG 519
>UniRef50_UPI0000D57178 Cluster: PREDICTED: similar to CG14396-PA,
isoform A; n=1; Tribolium castaneum|Rep: PREDICTED:
similar to CG14396-PA, isoform A - Tribolium castaneum
Length = 1065
Score = 121 bits (292), Expect = 6e-26
Identities = 74/246 (30%), Positives = 126/246 (51%), Gaps = 31/246 (12%)
Query: 474 ELEKTEKKQMLQELDLLIKTSEHENVISLIGICET-NTTLLVVLEDIKK-TLKEMLLLSR 531
+ ++E +L E LL + S H NVI L+G+C + +++E + +L+ L SR
Sbjct: 782 DARESELNDLLSEYQLLKEVS-HPNVIRLLGVCTAPGGPIYLIIEFAEHGSLRNYLRRSR 840
Query: 532 ---------------QRDIQNNK--FCSITENKVLQICVQVARGMEYLHTRKIVHKKLCC 574
+ D+ ++ +T ++L Q+ +GM YL K+VH+ L
Sbjct: 841 HLKSECGRLPSSTVDENDVHYDEPNISKVTPKEILSFAWQICKGMAYLSEIKLVHRDLAA 900
Query: 575 RNMIISENGTVKIAGFGLSHLRSLHETPDY---------TRWTSHEMLRQTRYNPKADVW 625
RN++++ + KI+ FGL+ R ++E Y +W + E L Y K+DVW
Sbjct: 901 RNVLLAADQICKISDFGLT--RDIYEDDAYFKRSKGRVPVKWMAPESLSDHIYTNKSDVW 958
Query: 626 SFGVLMWEVLTLGATPYSHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDER 685
SFG+L+WE++TLGATPY +++ + +G R +P L+ + CW +DP++R
Sbjct: 959 SFGILVWELVTLGATPYPGIAVQNLFHLLRQGYRMERPDNCSPTLYNIMRSCWHIDPEQR 1018
Query: 686 PTFSSL 691
PTF L
Sbjct: 1019 PTFQEL 1024
>UniRef50_UPI00015B51DA Cluster: PREDICTED: similar to
ENSANGP00000013218; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000013218 - Nasonia
vitripennis
Length = 972
Score = 121 bits (291), Expect = 8e-26
Identities = 80/283 (28%), Positives = 134/283 (47%), Gaps = 24/283 (8%)
Query: 428 WNIPRNLIETDISCVVGVGTYXXXXXXXXXXXXXXXXXXXXXIAD--RELEKTEKKQMLQ 485
W PR+ + I V+G G + + + +E +L
Sbjct: 494 WEFPRSRLS--IEQVLGEGEFGRVLRAKAQDIAGWQGQTTVAVKTLKEDASASELADLLS 551
Query: 486 ELDLLIKTSEHENVISLIGICET-NTTLLVVLEDIK-KTLKEMLLLSRQRDIQNNKFC-- 541
E LL K ++H NVI L+G C T + +++E + +L+ L SR + +
Sbjct: 552 EYQLL-KEAQHPNVIRLLGACTTAGGPIYLIIEFAEFGSLRNYLRRSRHLESEGRPSIDP 610
Query: 542 ----SITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRS 597
+IT +L Q+++GM YL K+VH+ L RN+++ KI+ FGL+ R
Sbjct: 611 VVNYTITPRDILSFAWQISKGMAYLADIKLVHRDLAARNVLLGAGKVCKISDFGLT--RD 668
Query: 598 LHETPDY---------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNK 648
++E Y +W + E L Y K+DVWSFGVL+WE++TLGA+PY
Sbjct: 669 VYEDDAYLKRSKGRVPVKWMAPESLADHVYTSKSDVWSFGVLLWELVTLGASPYPGVDVH 728
Query: 649 DVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSL 691
++ + + G R +P+ +L+++ + CW +P RP+F L
Sbjct: 729 NLYNLLKAGYRMEKPANCSHQLYKLMVSCWHDEPGMRPSFKEL 771
>UniRef50_UPI0000DB7A0A Cluster: PREDICTED: similar to FMS-like
tyrosine kinase 1; n=1; Apis mellifera|Rep: PREDICTED:
similar to FMS-like tyrosine kinase 1 - Apis mellifera
Length = 955
Score = 121 bits (291), Expect = 8e-26
Identities = 57/168 (33%), Positives = 94/168 (55%), Gaps = 11/168 (6%)
Query: 534 DIQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLS 593
D +++ I +L QVARGMEYL RK++H L RN++++EN VKI FGL+
Sbjct: 540 DYKDHNLKPICTQDLLSWAFQVARGMEYLSQRKVLHGDLAARNILLAENNVVKICDFGLA 599
Query: 594 HLRSLHETPDYTR---------WTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSH 644
+++++ +Y + W + E +R ++ ++D+WSFG+++WE TL TPY
Sbjct: 600 --KTMYKDNNYKKKGGGLLPIKWMAIESIRDRIFSTQSDIWSFGIVLWEFFTLAETPYPG 657
Query: 645 SGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLV 692
+ +++ G R QP Y E++ + QCW P RP+F+ LV
Sbjct: 658 MEAEKQYQKLIEGYRLEQPEYATSEIYNIMYQCWMAKPSLRPSFTQLV 705
>UniRef50_Q4H3M7 Cluster: Ephrin receptor; n=3; Ciona|Rep: Ephrin
receptor - Ciona intestinalis (Transparent sea squirt)
Length = 1006
Score = 121 bits (291), Expect = 8e-26
Identities = 74/231 (32%), Positives = 118/231 (51%), Gaps = 20/231 (8%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNN 538
E+ L E ++ + +H NVI L G+ + L+++ E ++ + L +++ I +
Sbjct: 683 ERSDFLGEASIMGQF-DHPNVIRLEGVVTKSRPLMIITEFMENGSLDAFLRNQEGKIPS- 740
Query: 539 KFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSL 598
+TE + + +A+GMEYL VH+ L RN++++ N K++ FGLS +
Sbjct: 741 --AQLTE-----MLLSIAQGMEYLSNMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLEQ 793
Query: 599 HETPD---YT--------RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGN 647
E D YT RWTS E + ++ +DVWSFG++MWEV++ G PY N
Sbjct: 794 LEEDDVAMYTTRGGMIPIRWTSPEAITMRTFSTSSDVWSFGIVMWEVMSFGERPYWEMSN 853
Query: 648 KDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPF 698
+DV + G R P Y + V L+CW+ D +RP FS LV L F
Sbjct: 854 QDVVQFVDSGYRLPPPCYCPRIIHSVMLECWKRDRTQRPNFSHLVTLLDRF 904
>UniRef50_A7S934 Cluster: Predicted protein; n=4; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 304
Score = 121 bits (291), Expect = 8e-26
Identities = 71/254 (27%), Positives = 125/254 (49%), Gaps = 27/254 (10%)
Query: 477 KTEKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVV---------LEDIKKTLK--- 524
++E + + E+ ++ +H N++SL+G C N L +V L+ IK+
Sbjct: 53 ESELRDLCNEIAIMALVGDHPNIVSLLGACTVNGPLWLVVKLAENGCFLDYIKEHRSVVE 112
Query: 525 ----EMLLLSRQRDIQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIIS 580
E + S + + + +TE + + ++A+GM +L +K VH+ L RN++++
Sbjct: 113 YENTENKIHSYENVTEKTQGAPMTEKEKFKFAYEIAKGMRHLEKKKCVHRDLAARNILLN 172
Query: 581 ENGTVKIAGFGLSHLRSLHETPDY---------TRWTSHEMLRQTRYNPKADVWSFGVLM 631
+ ++ FGLS R ++E+ Y RW + E L Y K+DVWS+GVL+
Sbjct: 173 VDNVAMVSDFGLS--RDVYESGAYDNTTGGVLPVRWMAIESLEDYTYTTKSDVWSYGVLL 230
Query: 632 WEVLTLGATPYSHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSL 691
WE+ + G PY+ ++ R+ +G R +PS EL+ + +CW +P RP FS +
Sbjct: 231 WEMESGGLMPYAGMSGVEILERLKQGYRLEKPSCCSQELYALMYECWNPEPKNRPAFSII 290
Query: 692 VIELTPFSEAPGTR 705
V L A R
Sbjct: 291 VSRLEETLRAKAVR 304
>UniRef50_P34925 Cluster: Tyrosine-protein kinase RYK precursor;
n=37; Euteleostomi|Rep: Tyrosine-protein kinase RYK
precursor - Homo sapiens (Human)
Length = 604
Score = 121 bits (291), Expect = 8e-26
Identities = 73/217 (33%), Positives = 114/217 (52%), Gaps = 11/217 (5%)
Query: 496 HENVISLIGIC-ETNTTLLVVLEDIK-KTLKEMLLLSRQRDIQNNKFCSITENKVLQICV 553
H N++ + +C E +V+L + LK L L + + ++ N +I++ ++ + +
Sbjct: 387 HRNLLPITHVCIEEGEKPMVILPYMNWGNLK--LFLRQCKLVEANNPQAISQQDLVHMAI 444
Query: 554 QVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSH------LRSLHETPDY-TR 606
Q+A GM YL R+++HK L RN +I + VKI LS L + + R
Sbjct: 445 QIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVR 504
Query: 607 WTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRILRGMRPSQPSYV 666
W + E L ++ +DVW+FGV +WE++TLG TPY ++ + + G R +QP
Sbjct: 505 WMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINC 564
Query: 667 GDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEAPG 703
DELF V CW +DP+ERP F LV LT F A G
Sbjct: 565 PDELFAVMACCWALDPEERPKFQQLVQCLTEFHAALG 601
>UniRef50_UPI0000D55DFF Cluster: PREDICTED: similar to Insulin-like
growth factor 1 receptor precursor (Insulin-like growth
factor I receptor) (IGF-I receptor) (CD221 antigen); n=1;
Tribolium castaneum|Rep: PREDICTED: similar to
Insulin-like growth factor 1 receptor precursor
(Insulin-like growth factor I receptor) (IGF-I receptor)
(CD221 antigen) - Tribolium castaneum
Length = 1277
Score = 120 bits (290), Expect = 1e-25
Identities = 74/228 (32%), Positives = 118/228 (51%), Gaps = 18/228 (7%)
Query: 478 TEKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKK-TLKEMLLLSRQRDIQ 536
+ K + L E ++ SE +VI L+GI V++E +++ LK L R R
Sbjct: 958 SSKMEFLNEGSVMKSFSETHHVIKLLGIVSRGDRPFVIMELMERGDLKSYL--RRCRGPS 1015
Query: 537 NNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLR 596
N +T N++ ++ ++A GM YL +K VH+ L RN +++ + TVKI FG++ R
Sbjct: 1016 QN----LTTNEIYRMASEIADGMAYLSVKKFVHRDLAARNCMVAADRTVKIGDFGMA--R 1069
Query: 597 SLHETPDYT---------RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGN 647
++ET Y RW + E L + +DVWS+GV++WE+ TL PY G
Sbjct: 1070 DIYETDYYRKGTAGLLPIRWMAPESLADGVFTTDSDVWSYGVVLWEMATLAELPYQGLGA 1129
Query: 648 KDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIEL 695
++V + G P D L ++ CW+ P++RPTF S+V EL
Sbjct: 1130 EEVLQFVTSGRTLDMPPQCSDLLHKIMSACWKWRPNDRPTFFSIVDEL 1177
>UniRef50_UPI00015A3FB5 Cluster: hypothetical protein LOC553690;
n=3; Danio rerio|Rep: hypothetical protein LOC553690 -
Danio rerio
Length = 981
Score = 120 bits (290), Expect = 1e-25
Identities = 73/230 (31%), Positives = 118/230 (51%), Gaps = 12/230 (5%)
Query: 477 KTEKKQM--LQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKK-TLKEMLLLSRQR 533
+ E+ QM +E D+ K S H NV L+GIC +++E LK+ L +S+ +
Sbjct: 746 RDEQMQMDFRRECDMFAKLS-HSNVARLLGICREVEPHYMIMEYTDMGDLKQYLRVSKSK 804
Query: 534 DIQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLS 593
D + K ++ + + +C+QVARGME+L ++ VHK L RN +IS +K++ GLS
Sbjct: 805 D-EKVKVQPLSTKQKVSVCLQVARGMEHLSNQRFVHKDLAARNCLISSKRQIKVSSLGLS 863
Query: 594 ----HLRSLHETPDY--TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGN 647
H Y RW E + + ++ K DVWSF VLMWEV + G PY+ +
Sbjct: 864 KDVYSSEYYHYRQSYIPLRWLPSEAVFEDDFSTKTDVWSFAVLMWEVFSFGEMPYADLAD 923
Query: 648 KDVGSRILRG-MRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELT 696
V + G ++ P +F++ ++CW P +R +FS + L+
Sbjct: 924 DKVLEALQDGKLKLCPPQGCPSRVFKLMVRCWAASPKDRLSFSEICSALS 973
>UniRef50_Q9Y1Y7 Cluster: Protein tyrosine kinase; n=1; Ephydatia
fluviatilis|Rep: Protein tyrosine kinase - Ephydatia
fluviatilis
Length = 709
Score = 120 bits (290), Expect = 1e-25
Identities = 75/241 (31%), Positives = 123/241 (51%), Gaps = 20/241 (8%)
Query: 474 ELEKTEKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQR 533
E ++ QML+E + +K +H N++SLIG+C + ++ + L +QR
Sbjct: 424 ETSDSQISQMLEE-SVKMKDFDHPNILSLIGVCIAIESSPYIVMPFMANGSLLSYLKQQR 482
Query: 534 D---IQNNK---FCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKI 587
I N + T+ +L IC+Q+A+GMEYL ++K VH+ L RN +I N +K+
Sbjct: 483 HNLTIANGAEQDLITETQRVLLSICLQIAKGMEYLASQKFVHRDLAARNCMIDLNNVIKV 542
Query: 588 AGFGLS---HLRSLHETPDY--------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLT 636
A FGLS + ++ + D RW + E ++ K DVWS+GV WEV T
Sbjct: 543 ADFGLSEDMYAKNYYRQSDVEECKVKLPIRWMAPESFHDGVFSEKTDVWSYGVTCWEVFT 602
Query: 637 LGATPYSHSGNKDVGSRILRGMRPSQPSYV--GDELFQVCLQCWQVDPDERPTFSSLVIE 694
LG PY + + G R +PS D+++ + +CW + ++RP FS+LV+
Sbjct: 603 LGKIPYPGVTPFTLIKYLDEGGRLEKPSNAACSDQIYDLMRKCWCQESEDRPPFSNLVLA 662
Query: 695 L 695
+
Sbjct: 663 I 663
>UniRef50_P24348 Cluster: Receptor tyrosine-protein kinase let-23
precursor; n=3; Caenorhabditis|Rep: Receptor
tyrosine-protein kinase let-23 precursor - Caenorhabditis
elegans
Length = 1323
Score = 120 bits (290), Expect = 1e-25
Identities = 75/281 (26%), Positives = 131/281 (46%), Gaps = 18/281 (6%)
Query: 430 IPRNLIETDISCVVGVGTYXXXXXXXXXXXXXXXXXXXXXIADRELEKTEKKQMLQELDL 489
IP + ++T + +G G + I + ++++ +ML+E
Sbjct: 878 IPSSELQTKLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDEMLEEATN 937
Query: 490 LIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNKFCSITENKVL 549
+ + H+N++ +IG C + L +V I + L + Q ++ +K +VL
Sbjct: 938 MFRL-RHDNLLKIIGFCMHDDGLKIVT--IYRPLGNL-----QNFLKLHKENLGAREQVL 989
Query: 550 QICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSLHETPDYT---- 605
C Q+A GM+YL +++VH+ L RN+++ + V+I FGLS + H+ T
Sbjct: 990 Y-CYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILK-HDADSITIKSG 1047
Query: 606 ----RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRILRGMRPS 661
+W + E+ + Y +DVW+FGV WE++T G +PY + + + G R S
Sbjct: 1048 KVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLS 1107
Query: 662 QPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEAP 702
QP +L+Q L+CW DP RP F L F + P
Sbjct: 1108 QPPNCSQDLYQELLRCWMADPKSRPGFEILYERFKEFCKVP 1148
>UniRef50_Q7YZX2 Cluster: Bruton's tyrosine kinase-like protein;
n=1; Suberites domuncula|Rep: Bruton's tyrosine
kinase-like protein - Suberites domuncula (Sponge)
Length = 700
Score = 120 bits (289), Expect = 1e-25
Identities = 60/208 (28%), Positives = 104/208 (50%), Gaps = 13/208 (6%)
Query: 490 LIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNKFCSITENKVL 549
++K +HEN++ L G+C N + +V E + L R+ ++ + +L
Sbjct: 479 VMKQFQHENLVKLYGVCTKNGPIFIVQELMVNGCLLQFLRQRKELVEKTEI-------IL 531
Query: 550 QICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHL------RSLHETPD 603
+ Q+ M+YL +H+ L RN ++ E VK+A FGL+ + T
Sbjct: 532 DMATQICSAMKYLEESGFIHRDLAARNCLVGERNVVKVADFGLARFVVDDEYTASEGTKF 591
Query: 604 YTRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRILRGMRPSQP 663
+W + E++ +++ K+DVWSFG+L+WE+ T G TPY N V +L G R +P
Sbjct: 592 PIKWAAPEVITHAKFSSKSDVWSFGILLWELWTGGKTPYPTFTNSQVLDEVLMGYRLDRP 651
Query: 664 SYVGDELFQVCLQCWQVDPDERPTFSSL 691
E++ + +CW + D+RP F +L
Sbjct: 652 KQCPPEVYALMGKCWLTNSDDRPQFKTL 679
>UniRef50_Q7KJ08 Cluster: Receptor protein tyrosine kinase ALK splice
variant A; n=9; Diptera|Rep: Receptor protein tyrosine
kinase ALK splice variant A - Drosophila melanogaster
(Fruit fly)
Length = 1701
Score = 120 bits (289), Expect = 1e-25
Identities = 73/247 (29%), Positives = 122/247 (49%), Gaps = 18/247 (7%)
Query: 473 RELEKTEKKQ-MLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSR 531
RE K EK++ L+E ++ K + H N++ LIG+C +VLE + + L
Sbjct: 1230 REDPKREKEEDFLKEAAIMAKFN-HPNMVHLIGVCFDRQPYYIVLELLAGGDLQKFLREN 1288
Query: 532 QRDIQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENG---TVKIA 588
+ + +T +L + VA+G Y+ +++ +H+ + RN ++S G VKIA
Sbjct: 1289 RNTPERPSL--LTMKDLLFCALDVAKGCRYMESKRFIHRDIAARNCLLSSKGPGRVVKIA 1346
Query: 589 GFGLSHLRSLHETPDYTR---------WTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGA 639
FG+S R ++ + Y + W E + K DVWSFG+L+WEV +LG
Sbjct: 1347 DFGMS--RDIYRSDYYRKGGKAMLPIKWMPPEAFLDGIFTSKTDVWSFGILLWEVFSLGR 1404
Query: 640 TPYSHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFS 699
+PY N V ++RG R P+ +++V CW P++RPTF +L+ LT +
Sbjct: 1405 SPYPGQHNTQVMELVVRGGRLGSPTECPVSIYKVMADCWNPTPEDRPTFITLLEHLTACT 1464
Query: 700 EAPGTRN 706
+ N
Sbjct: 1465 QDASIMN 1471
>UniRef50_Q6SAA3 Cluster: Epidermal growth factor receptor; n=39;
Drosophila melanogaster|Rep: Epidermal growth factor
receptor - Drosophila melanogaster (Fruit fly)
Length = 1325
Score = 120 bits (289), Expect = 1e-25
Identities = 65/222 (29%), Positives = 111/222 (50%), Gaps = 18/222 (8%)
Query: 490 LIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNKFCSITENKVL 549
++ + EH N++ L+ +C ++ +L+ +++ L D N I +L
Sbjct: 890 IMASVEHVNLLKLLAVCMSSQMMLIT---------QLMPLGCLLDYVRNNRDKIGSKALL 940
Query: 550 QICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSLHETPDYT---- 605
Q+A+GM YL +++VH+ L RN+++ VKI FGL+ L S ++ +Y
Sbjct: 941 NWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLS-SDSNEYKAAGG 999
Query: 606 ----RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRILRGMRPS 661
+W + E +R + K+DVW+FGV +WE+LT G P+ + KD+ I G++
Sbjct: 1000 KMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLE 1059
Query: 662 QPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEAPG 703
QP +++ L CW +D RPTF L F+ PG
Sbjct: 1060 QPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPG 1101
>UniRef50_Q06418 Cluster: Tyrosine-protein kinase receptor TYRO3
precursor; n=30; Tetrapoda|Rep: Tyrosine-protein kinase
receptor TYRO3 precursor - Homo sapiens (Human)
Length = 890
Score = 120 bits (289), Expect = 1e-25
Identities = 72/221 (32%), Positives = 119/221 (53%), Gaps = 22/221 (9%)
Query: 491 IKTSEHENVISLIGICETNTTL------LVVLEDIKK-TLKEMLLLSRQRDIQNNKFCSI 543
+K +H +V L+G+ + +V+L +K L LL SR I N F ++
Sbjct: 572 MKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASR---IGENPF-NL 627
Query: 544 TENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSLHETPD 603
+++ V +A GMEYL +R +H+ L RN +++E+ TV +A FGLS R ++
Sbjct: 628 PLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLS--RKIYSGDY 685
Query: 604 Y---------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRI 654
Y +W + E L Y ++DVW+FGV MWE++T G TPY+ N ++ + +
Sbjct: 686 YRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYL 745
Query: 655 LRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIEL 695
+ G R QP ++++ + QCW DP +RP+F+ L +EL
Sbjct: 746 IGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMEL 786
>UniRef50_P42686 Cluster: Tyrosine-protein kinase isoform SRK1;
n=11; Metazoa|Rep: Tyrosine-protein kinase isoform SRK1
- Spongilla lacustris (Freshwater sponge)
Length = 505
Score = 120 bits (289), Expect = 1e-25
Identities = 70/237 (29%), Positives = 117/237 (49%), Gaps = 15/237 (6%)
Query: 481 KQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNKF 540
++ LQE ++ K H +I L +C + +V E +K +L R D
Sbjct: 278 EEFLQEASIM-KRLRHPKLIQLYAVCTKEEPIYIVTELMK--YGSLLEYLRGED------ 328
Query: 541 CSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHL--RSL 598
+ +++ + QVA GM YL + +H+ L RN+++ E+G K+A FGL+ + +
Sbjct: 329 GVLKIEQLVDVAAQVASGMSYLEQQNYIHRDLAARNILVGEHGICKVADFGLARVIDEEI 388
Query: 599 HETPDYTR----WTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRI 654
+E + WT+ E R+ K+DVWSFGV+++E++T G PY N +V +I
Sbjct: 389 YEAHTGAKFPIKWTAPEAAMYNRFTIKSDVWSFGVVLYEIITYGRFPYPGMTNPEVLEKI 448
Query: 655 LRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEAPGTRNLSFTH 711
+ R P+ + + L CW+ DP RPTF +L +L F + G R+ H
Sbjct: 449 QQNYRMPCPANCPKQFHDIMLDCWREDPASRPTFETLQWQLEEFFNSEGYRDPDAIH 505
>UniRef50_UPI0000E471D0 Cluster: PREDICTED: similar to p80 protein,
partial; n=2; Strongylocentrotus purpuratus|Rep:
PREDICTED: similar to p80 protein, partial -
Strongylocentrotus purpuratus
Length = 526
Score = 120 bits (288), Expect = 2e-25
Identities = 71/213 (33%), Positives = 117/213 (54%), Gaps = 22/213 (10%)
Query: 495 EHENVISLIGICETNTTLLVVLEDIKK-TLKEMLLLSRQRDIQ--NNKFCSITENKVLQI 551
+H NV+SL+GIC L +VLE ++ LK+ L RDI+ K SIT +LQI
Sbjct: 5 DHPNVVSLLGICFKEKPLFIVLEYMEGGELKQFL-----RDIRPTEEKPSSITMKDLLQI 59
Query: 552 CVQVARGMEYLHTRKIVHKKLCCRNMIIS--ENG-TVKIAGFGLSHLRSLHETPDY---- 604
VA+G YL +R+ +H+ + RN++++ E+G KIA FG++ R ++ Y
Sbjct: 60 TQDVAQGCRYLESRRFIHRDIAARNILLTTKESGRAAKIADFGMA--RDIYRADYYRKGG 117
Query: 605 -----TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRILRGMR 659
+W E + + K DVW++GVL+WE+++LG PY N++V + G R
Sbjct: 118 QALLPVKWMPPEAFQDGIFTSKTDVWAYGVLLWEIISLGFMPYPGMSNQEVIQFVSAGER 177
Query: 660 PSQPSYVGDELFQVCLQCWQVDPDERPTFSSLV 692
+ P +F + QCW+ P++RP F++++
Sbjct: 178 MNPPRSCPQPVFNLMSQCWRHIPEDRPPFTTIL 210
>UniRef50_Q21038 Cluster: Putative uncharacterized protein ver-3; n=2;
Caenorhabditis|Rep: Putative uncharacterized protein
ver-3 - Caenorhabditis elegans
Length = 1227
Score = 120 bits (288), Expect = 2e-25
Identities = 58/160 (36%), Positives = 93/160 (58%), Gaps = 9/160 (5%)
Query: 542 SITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLS--HLRSLH 599
++ + +L I +Q+A+GM +L VH+ L CRN++I++ V+IA FGLS H +
Sbjct: 1001 ALCTSDLLSIGLQIAKGMAWLADVPCVHRDLACRNVLITKTKIVRIADFGLSKKHTNKTY 1060
Query: 600 -------ETPDYTRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGS 652
+TP RW E + + ++ K+DVWSFG+ ++E+ TLG TPY + +V
Sbjct: 1061 YRTKKSKDTPLPVRWMPLECIEEFKFTQKSDVWSFGICLYEIFTLGGTPYPNCDTFNVIE 1120
Query: 653 RILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLV 692
I G R QP Y DE++++ CWQ +P +RPTF+ +
Sbjct: 1121 FIRNGNRNKQPEYCHDEIYELMKVCWQFNPKDRPTFNDCI 1160
>UniRef50_O76148 Cluster: Tyrosine-protein kinase receptor; n=1;
Anopheles sp.|Rep: Tyrosine-protein kinase receptor -
Anopheles sp
Length = 863
Score = 120 bits (288), Expect = 2e-25
Identities = 67/223 (30%), Positives = 117/223 (52%), Gaps = 19/223 (8%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNN 538
EK++ LQE L+ +H+++ L+G+C LL+++E ++ ++L + +
Sbjct: 494 EKQEFLQEAQLM-SNFKHKHITRLLGVCLEADALLIIMELMQG--GDLLSYLPAQPLP-G 549
Query: 539 KFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIIS----ENGTVKIAGFGLSH 594
+ +T ++ +C VA G YL VH+ L CRN ++S + VKI FGL+
Sbjct: 550 QAARLTMLDLISMCQDVASGCRYLEEMHFVHRDLACRNCLVSSTDPRDRVVKIGDFGLA- 608
Query: 595 LRSLHETPDY---------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHS 645
R +++ Y RW S E L + ++D+W+FGVL+WE++TLG PY
Sbjct: 609 -RDIYKNDYYRKEGEGLLPVRWMSPESLVDGVFTSQSDIWAFGVLLWEIMTLGEQPYQAK 667
Query: 646 GNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTF 688
N +V + + G +P +E++++ CW+ P+ERPTF
Sbjct: 668 NNVEVLNHVREGGHLDRPKVCPNEMYELMKYCWKFSPEERPTF 710
>UniRef50_Q5GIT4 Cluster: Vascular endothelial growth factor receptor
2 homolog B precursor; n=8; Clupeocephala|Rep: Vascular
endothelial growth factor receptor 2 homolog B precursor
- Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 1357
Score = 120 bits (288), Expect = 2e-25
Identities = 64/174 (36%), Positives = 99/174 (56%), Gaps = 12/174 (6%)
Query: 532 QRDIQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFG 591
Q + +++ + +T ++ QVA+GME+L +RK +H+ L RN+++SEN VKI FG
Sbjct: 1000 QDEQESSDWDHLTMEDLISYSFQVAKGMEFLASRKCIHRDLAARNILLSENSVVKICDFG 1059
Query: 592 LSHLRSLHETPDYTR---------WTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPY 642
L+ R +++ PDY R W + E + Y ++DV SFGVL+WE+ +LGA+PY
Sbjct: 1060 LA--RDVYKDPDYVRKGDARLPLKWMAPETIFDRVYTTQSDVRSFGVLLWEIFSLGASPY 1117
Query: 643 -SHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIEL 695
++ R+ G R P Y E++Q L CW P +RPTF+ LV L
Sbjct: 1118 PGVCIDESFCRRLKEGTRMRAPDYATPEIYQTMLDCWLDRPLDRPTFTQLVEHL 1171
>UniRef50_P00529 Cluster: Tyrosine-protein kinase transforming
protein ros; n=3; root|Rep: Tyrosine-protein kinase
transforming protein ros - Avian sarcoma virus (strain
UR2)
Length = 402
Score = 120 bits (288), Expect = 2e-25
Identities = 79/253 (31%), Positives = 126/253 (49%), Gaps = 28/253 (11%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNN 538
EK + L+E L+ K +H +++ L+G+C N ++LE ++ LLS R +
Sbjct: 143 EKSEFLKEAHLMSKF-DHPHILKLLGVCLLNEPQYLILE----LMEGGDLLSYLRGARKQ 197
Query: 539 KFCS--ITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISE------NGTVKIAGF 590
KF S +T +L IC+ + +G YL + +H+ L RN ++SE + VKI F
Sbjct: 198 KFQSPLLTLTDLLDICLDICKGCVYLEKMRFIHRDLAARNCLVSEKQYGSCSRVVKIGDF 257
Query: 591 GLSHLRSLHETPDY---------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATP 641
GL+ R +++ Y RW + E L + +DVW+FGVL+WE LTLG P
Sbjct: 258 GLA--RDIYKNDYYRKRGEGLLPVRWMAPESLIDGVFTNHSDVWAFGVLVWETLTLGQQP 315
Query: 642 YSHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEA 701
Y N +V + G R P+ D++ + +CW DP RPTF + +L +
Sbjct: 316 YPGLSNIEVLHHVRSGGRLESPNNCPDDIRDLMTRCWAQDPHNRPTFFYIQHKLQEIRHS 375
Query: 702 PGTRNLSFTHYNG 714
P L F+++ G
Sbjct: 376 P----LCFSYFLG 384
>UniRef50_Q9YI66 Cluster: Developmental receptor tyrosine kinase;
n=6; Bilateria|Rep: Developmental receptor tyrosine
kinase - Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 874
Score = 119 bits (287), Expect = 2e-25
Identities = 74/229 (32%), Positives = 121/229 (52%), Gaps = 19/229 (8%)
Query: 481 KQMLQELDLLIKTSEHENVISLIGIC------ETNTTLLVVLEDIKK-TLKEMLLLSRQR 533
+Q L+E + K H NVI LIG+ + +V+L +K L LL+SR
Sbjct: 542 EQCLKEAAYM-KDFHHPNVIQLIGVSLHRRAQQRLPIPMVILPFMKHGDLHTFLLMSRLG 600
Query: 534 DIQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLS 593
D F ++++ ++Q + +ARGMEYL + I+H+ L RN +++EN +V +A FGLS
Sbjct: 601 D---EPF-TVSQQILIQFMLDIARGMEYLSNKNIIHRDLAARNCMLNENMSVCVADFGLS 656
Query: 594 -------HLRSLHETPDYTRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSG 646
+ R + +W + E L Y ++DVW+FGV MWE++T G TPY
Sbjct: 657 KKIYSGDYYRQGSVSKLPVKWIALESLADNVYTTQSDVWAFGVTMWEIMTRGQTPYPGVE 716
Query: 647 NKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIEL 695
N ++ +++G R QP +++++ CW P RP+F L+ +L
Sbjct: 717 NSEIYEYLIKGERLKQPPDCPADIYEIMHSCWSPVPKCRPSFQHLIDQL 765
>UniRef50_A7SI92 Cluster: Predicted protein; n=2; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 312
Score = 119 bits (287), Expect = 2e-25
Identities = 55/155 (35%), Positives = 91/155 (58%), Gaps = 6/155 (3%)
Query: 543 ITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLS-HL-RSLHE 600
I+ ++ QVA+GMEYL R VH+ L RN+++ +N K+A FGL+ H+ L++
Sbjct: 139 ISSGDLMAFAWQVAQGMEYLARRGFVHRDLAARNVLVGDNKVAKVADFGLTRHMYEDLYQ 198
Query: 601 TPDYTR----WTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRILR 656
+ W S E + + ++DVW++GV +WE++TLG TPY GN+++ +
Sbjct: 199 GKTSRKLPLKWMSIEAIFDQAFTSQSDVWAYGVFLWELVTLGGTPYPTIGNRELLKLLKE 258
Query: 657 GMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSL 691
G R +P D+L+ + L CW+ P++RPTF +L
Sbjct: 259 GYRMEKPDMCNDDLYTIMLSCWKDKPEDRPTFENL 293
>UniRef50_P35916 Cluster: Vascular endothelial growth factor receptor
3 precursor; n=42; Euteleostomi|Rep: Vascular endothelial
growth factor receptor 3 precursor - Homo sapiens (Human)
Length = 1298
Score = 119 bits (287), Expect = 2e-25
Identities = 61/149 (40%), Positives = 87/149 (58%), Gaps = 12/149 (8%)
Query: 554 QVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSLHETPDYTR------- 606
QVARGME+L +RK +H+ L RN+++SE+ VKI FGL+ R +++ PDY R
Sbjct: 1020 QVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLA--RDIYKDPDYVRKGSARLP 1077
Query: 607 --WTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPY-SHSGNKDVGSRILRGMRPSQP 663
W + E + Y ++DVWSFGVL+WE+ +LGA+PY N++ R+ G R P
Sbjct: 1078 LKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTRMRAP 1137
Query: 664 SYVGDELFQVCLQCWQVDPDERPTFSSLV 692
+ ++ L CW DP RP FS LV
Sbjct: 1138 ELATPAIRRIMLNCWSGDPKARPAFSELV 1166
>UniRef50_UPI00015B5C00 Cluster: PREDICTED: similar to VEGFR-A splice
form A; n=1; Nasonia vitripennis|Rep: PREDICTED: similar
to VEGFR-A splice form A - Nasonia vitripennis
Length = 1294
Score = 119 bits (286), Expect = 3e-25
Identities = 57/166 (34%), Positives = 90/166 (54%), Gaps = 7/166 (4%)
Query: 534 DIQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLS 593
D ++ I +L QVARGMEYL RK++H L RN++++EN VKI FGL+
Sbjct: 883 DYKDRNLKPICTQDLLSWAFQVARGMEYLCQRKVLHGDLAARNILLAENNVVKICDFGLA 942
Query: 594 -------HLRSLHETPDYTRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSG 646
+ + + P +W + E +R ++ ++D+WSFG+++WE TL TPY
Sbjct: 943 KTMYKNDNYKKQGDGPVPIKWMAIESIRDWIFSTQSDIWSFGIVLWEFFTLAETPYPGMQ 1002
Query: 647 NKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLV 692
+ +++ G R QP Y ++ LQCW+ P RP+F+ LV
Sbjct: 1003 AEKQYQKLIEGYRMEQPKYATKAIYDTMLQCWKAKPTLRPSFTELV 1048
>UniRef50_Q5DM52 Cluster: Receptor tyrosine kinase Torso-like
protein; n=1; Tribolium castaneum|Rep: Receptor tyrosine
kinase Torso-like protein - Tribolium castaneum (Red
flour beetle)
Length = 803
Score = 119 bits (286), Expect = 3e-25
Identities = 62/158 (39%), Positives = 91/158 (57%), Gaps = 11/158 (6%)
Query: 543 ITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSLHETP 602
I +L I QVA GME+L ++VH+ L RN+++ EN TVK++ FGLS R +++
Sbjct: 589 IQPKHLLSIARQVALGMEHLAKTRVVHRDLAARNVLVCENHTVKVSDFGLS--RDVYQDN 646
Query: 603 DY---------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSR 653
Y RW + E L RY +DVWSFGVL+WE++TLG TPY + ++
Sbjct: 647 VYCKNGGGKLPVRWMALESLTHQRYTTYSDVWSFGVLLWEIVTLGGTPYVGVHSSELLDF 706
Query: 654 ILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSL 691
+ G R ++P+ +L+ V L CW+ P RPTF+ L
Sbjct: 707 LKSGNRLARPANCSPDLYAVMLNCWKECPKNRPTFTEL 744
>UniRef50_P08922 Cluster: Proto-oncogene tyrosine-protein kinase ROS
precursor; n=20; Eumetazoa|Rep: Proto-oncogene
tyrosine-protein kinase ROS precursor - Homo sapiens
(Human)
Length = 2347
Score = 119 bits (286), Expect = 3e-25
Identities = 72/234 (30%), Positives = 119/234 (50%), Gaps = 19/234 (8%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNN 538
EK + L+E L+ K + H N++ +G+C N ++LE ++ ++L R+ +
Sbjct: 1990 EKIEFLKEAHLMSKFN-HPNILKQLGVCLLNEPQYIILELMEGG--DLLTYLRKARMATF 2046
Query: 539 KFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENG-----TVKIAGFGLS 593
+T ++ +CV +++G YL +H+ L RN ++S VKI FGL+
Sbjct: 2047 YGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLA 2106
Query: 594 HLRSLHETPDY---------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSH 644
R +++ Y RW + E L + ++DVWSFG+L+WE+LTLG PY
Sbjct: 2107 --RDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPA 2164
Query: 645 SGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPF 698
N DV + + G R P D+L+ + QCW +PD+RPTF + +L F
Sbjct: 2165 HSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLF 2218
>UniRef50_Q25410 Cluster: Putative molluscan insulin-related
peptide(s) receptor precursor (EC 2.7.10.1) [Contains:
Putative molluscan insulin-related peptide(s) receptor
alpha chain; Putative molluscan insulin-related
peptide(s) receptor beta chain]; n=2; Coelomata|Rep:
Putative molluscan insulin-related peptide(s) receptor
precursor (EC 2.7.10.1) [Contains: Putative molluscan
insulin-related peptide(s) receptor alpha chain; Putative
molluscan insulin-related peptide(s) receptor beta chain]
- Lymnaea stagnalis (Great pond snail)
Length = 1607
Score = 119 bits (286), Expect = 3e-25
Identities = 70/229 (30%), Positives = 118/229 (51%), Gaps = 12/229 (5%)
Query: 478 TEKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQN 537
+++++ L+E + + H +V+ L+G+ T LV++E + + L + D +
Sbjct: 1081 SDRREFLKEATTMKEFHCH-HVVKLLGVVSTGQPALVIMELMALGDLKNYLRGHRPDEDH 1139
Query: 538 NKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRS 597
+LQ+ ++A GM YL +K VH+ L RN ++SE TVKI FG++ R
Sbjct: 1140 PGVMPPHLLDILQMAGEIADGMAYLADKKFVHRDLAARNCMVSEERTVKIGDFGMT--RD 1197
Query: 598 LHETPDY---------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNK 648
++ET Y RW + E L+ + +DVWS+GV+MWE++TL A PY N+
Sbjct: 1198 IYETDYYRKGGKGMLPVRWMAPESLKDGVFTSLSDVWSYGVVMWEMVTLAAQPYQGLSNE 1257
Query: 649 DVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTP 697
+V I G P +E+ + CW P++RPTF +++ L P
Sbjct: 1258 EVVKFISDGYIMELPENCPNEMAYLMQHCWAKKPNQRPTFKAIIEYLLP 1306
>UniRef50_Q9PVZ4 Cluster: Insulin receptor precursor (EC 2.7.10.1)
(IR) (Xe-InsR) (XTK-1b) [Contains: Insulin receptor
subunit alpha; Insulin receptor subunit beta]; n=6;
Euteleostomi|Rep: Insulin receptor precursor (EC
2.7.10.1) (IR) (Xe-InsR) (XTK-1b) [Contains: Insulin
receptor subunit alpha; Insulin receptor subunit beta] -
Xenopus laevis (African clawed frog)
Length = 1362
Score = 119 bits (286), Expect = 3e-25
Identities = 73/258 (28%), Positives = 128/258 (49%), Gaps = 15/258 (5%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNN 538
E+ + L E ++ K +V+ L+G+ LV++E + + L S + D +NN
Sbjct: 1056 ERIEFLNEASVM-KAFNCHHVVRLLGVVSKGQPTLVIMELMAHGDLKSYLRSLRPDAENN 1114
Query: 539 KF-CSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRS 597
+ T +++Q+ +++ GM YL+ +K VH+ L RN +++++ VKI FG++ R
Sbjct: 1115 PGRLAPTLKEIIQMAAEISDGMAYLNAKKFVHRDLAARNCMVADDYAVKIGDFGMT--RD 1172
Query: 598 LHETPDY---------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNK 648
++ET Y RW S E L+ + +DVWSFGV++WE+ +L PY N+
Sbjct: 1173 IYETDYYRKGGKGLLPVRWMSPESLKDGVFTAFSDVWSFGVVLWEITSLAEQPYQGLSNE 1232
Query: 649 DVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEAPGTRNLS 708
V ++ G P L + CWQ +P RPTF +I++ P +++S
Sbjct: 1233 QVLKFVMDGGSLDHPENCPPRLHSLMQMCWQYNPKMRPTFLE-IIDMLKDDLRPSFQDVS 1291
Query: 709 FTHYNGFEFEPHIPQYEV 726
F +Y+ P E+
Sbjct: 1292 F-YYSDENKPPETDDLEI 1308
>UniRef50_P41240 Cluster: Tyrosine-protein kinase CSK; n=21;
Deuterostomia|Rep: Tyrosine-protein kinase CSK - Homo
sapiens (Human)
Length = 450
Score = 119 bits (286), Expect = 3e-25
Identities = 66/199 (33%), Positives = 103/199 (51%), Gaps = 10/199 (5%)
Query: 496 HENVISLIG-ICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNKFCSITENKVLQICVQ 554
H N++ L+G I E L +V E + K L SR R + C +L+ +
Sbjct: 245 HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGD-C------LLKFSLD 297
Query: 555 VARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLS-HLRSLHETPDY-TRWTSHEM 612
V MEYL VH+ L RN+++SE+ K++ FGL+ S +T +WT+ E
Sbjct: 298 VCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEA 357
Query: 613 LRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRILRGMRPSQPSYVGDELFQ 672
LR+ +++ K+DVWSFG+L+WE+ + G PY KDV R+ +G + P +++
Sbjct: 358 LREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYE 417
Query: 673 VCLQCWQVDPDERPTFSSL 691
V CW +D RP+F L
Sbjct: 418 VMKNCWHLDAAMRPSFLQL 436
>UniRef50_UPI0000DB6DD4 Cluster: PREDICTED: similar to Insulin-like
growth factor 1 receptor precursor (Insulin-like growth
factor I receptor) (IGF-I receptor); n=1; Apis
mellifera|Rep: PREDICTED: similar to Insulin-like growth
factor 1 receptor precursor (Insulin-like growth factor
I receptor) (IGF-I receptor) - Apis mellifera
Length = 855
Score = 118 bits (285), Expect = 4e-25
Identities = 76/296 (25%), Positives = 142/296 (47%), Gaps = 19/296 (6%)
Query: 428 WNIPRNLIETDISCVVGVGTYXXXXXXXXXXXXXXXXXXXXXI--ADRELEKTEKKQMLQ 485
W +PR IE S +G GT+ + +++ E+ + L
Sbjct: 323 WEVPREKIEMLRS--LGTGTFGMVYEGIAKDIVKGKSEVRCAVKTVNKDATDRERIEFLN 380
Query: 486 ELDLLIKTSEHENVISLIGICETNTTLLVVLE-DIKKTLKEMLLLSRQRDIQNNKFCSIT 544
E ++ K + +V+ L+G+ LV++E + LK L R + +N +
Sbjct: 381 EASVM-KGFDAHHVVKLLGVVTRGQPTLVIMELMVNGDLKRYLRSHRPCENMSNAPPKL- 438
Query: 545 ENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSLHETPDY 604
+++LQ+ +++A GM YL T+K VH+ L RN +++E+ TVK+ FG++ R ++E Y
Sbjct: 439 -DRILQMAIEIADGMAYLSTKKFVHRDLAARNCMVAEDLTVKVGDFGMT--RDIYERDYY 495
Query: 605 ---------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRIL 655
RW + E L+ ++ +DVWS+GV++WE++T + PY N+ V ++
Sbjct: 496 RKGSKGLLPVRWMAPESLKDGVFSSYSDVWSYGVVLWEMVTFASQPYQGLSNEQVLRYVI 555
Query: 656 RGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEAPGTRNLSFTH 711
G +P + L+++ + W+ RPTF + L ++ + +SF H
Sbjct: 556 EGGVMERPENCPELLYELMKRTWRHKATRRPTFMDIASMLLKHIDSDSFQEVSFYH 611
>UniRef50_P00521 Cluster: Tyrosine-protein kinase transforming
protein Abl; n=15; root|Rep: Tyrosine-protein kinase
transforming protein Abl - Abelson murine leukemia virus
Length = 746
Score = 118 bits (285), Expect = 4e-25
Identities = 63/219 (28%), Positives = 117/219 (53%), Gaps = 14/219 (6%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNN 538
E ++ L+E ++ K +H N++ L+G+C ++ E + T +L R+ + Q
Sbjct: 165 EVEEFLKEAAVM-KEIKHPNLVQLLGVCTREPPFYIITEFM--TYGNLLDYLRECNRQE- 220
Query: 539 KFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRS- 597
++ +L + Q++ MEYL + +H+ L RN ++ EN VK+A FGLS L +
Sbjct: 221 ----VSAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTG 276
Query: 598 ----LHETPDYT-RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGS 652
H + +WT+ E L +++ K+DVW+FGVL+WE+ T G +PY V
Sbjct: 277 DTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYE 336
Query: 653 RILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSL 691
+ + R +P ++++++ CWQ +P +RP+F+ +
Sbjct: 337 LLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEI 375
>UniRef50_UPI0000E4736E Cluster: PREDICTED: similar to src-family
protein tyrosine kinase; n=2; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to src-family protein
tyrosine kinase - Strongylocentrotus purpuratus
Length = 387
Score = 118 bits (284), Expect = 6e-25
Identities = 61/208 (29%), Positives = 108/208 (51%), Gaps = 13/208 (6%)
Query: 490 LIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNKFCSITENKVL 549
++K HE ++ L +C + +V E + L S + +N K ++ +
Sbjct: 172 VMKKLRHEGIVQLYAVCSDKEPIYIVTELMSNGDLRTYLKSDK--CKNTKMTTL-----I 224
Query: 550 QICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHL--RSLHETPDYTR- 606
+ +A GM+YL ++ +VH+ L RN+++ + VKIA FG + L + ++ + +
Sbjct: 225 DMGAHIASGMDYLGSKNVVHRDLAARNVLVGKGNVVKIADFGRAQLMEKDVYVGEEGAKL 284
Query: 607 ---WTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRILRGMRPSQP 663
WT+ E + R+ K+DVWSFG+LM E++T G PY ++V ++ G R +
Sbjct: 285 PLKWTAPEAVLHGRFTIKSDVWSFGILMTEMVTFGGYPYKKMRTREVTKKVANGYRMPKM 344
Query: 664 SYVGDELFQVCLQCWQVDPDERPTFSSL 691
+ D L+ + L+CW DP +RPTF L
Sbjct: 345 DHCTDSLYMIMLKCWHKDPQQRPTFKYL 372
>UniRef50_P04626 Cluster: Receptor tyrosine-protein kinase erbB-2
precursor; n=36; Euteleostomi|Rep: Receptor
tyrosine-protein kinase erbB-2 precursor - Homo sapiens
(Human)
Length = 1255
Score = 118 bits (284), Expect = 6e-25
Identities = 64/211 (30%), Positives = 110/211 (52%), Gaps = 16/211 (7%)
Query: 499 VISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNKFCSITENKVLQICVQVARG 558
V L+GIC T+T LV + + LL R+ + + +L C+Q+A+G
Sbjct: 782 VSRLLGICLTSTVQLVT-----QLMPYGCLLDHVRENRGR----LGSQDLLNWCMQIAKG 832
Query: 559 MEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSLHETPDYT-------RWTSHE 611
M YL ++VH+ L RN+++ VKI FGL+ L + ET + +W + E
Sbjct: 833 MSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALE 892
Query: 612 MLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRILRGMRPSQPSYVGDELF 671
+ + R+ ++DVWS+GV +WE++T GA PY +++ + +G R QP +++
Sbjct: 893 SILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVY 952
Query: 672 QVCLQCWQVDPDERPTFSSLVIELTPFSEAP 702
+ ++CW +D + RP F LV E + + P
Sbjct: 953 MIMVKCWMIDSECRPRFRELVSEFSRMARDP 983
>UniRef50_P00519 Cluster: Proto-oncogene tyrosine-protein kinase
ABL1; n=35; root|Rep: Proto-oncogene tyrosine-protein
kinase ABL1 - Homo sapiens (Human)
Length = 1130
Score = 118 bits (284), Expect = 6e-25
Identities = 63/219 (28%), Positives = 116/219 (52%), Gaps = 14/219 (6%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNN 538
E ++ L+E ++ K +H N++ L+G+C ++ E + T +L R+ + Q
Sbjct: 279 EVEEFLKEAAVM-KEIKHPNLVQLLGVCTREPPFYIITEFM--TYGNLLDYLRECNRQE- 334
Query: 539 KFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRS- 597
+ +L + Q++ MEYL + +H+ L RN ++ EN VK+A FGLS L +
Sbjct: 335 ----VNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTG 390
Query: 598 ----LHETPDYT-RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGS 652
H + +WT+ E L +++ K+DVW+FGVL+WE+ T G +PY V
Sbjct: 391 DTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYE 450
Query: 653 RILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSL 691
+ + R +P ++++++ CWQ +P +RP+F+ +
Sbjct: 451 LLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEI 489
>UniRef50_UPI0000F1EB7D Cluster: PREDICTED: hypothetical protein;
n=3; Danio rerio|Rep: PREDICTED: hypothetical protein -
Danio rerio
Length = 510
Score = 118 bits (283), Expect = 7e-25
Identities = 62/208 (29%), Positives = 114/208 (54%), Gaps = 12/208 (5%)
Query: 490 LIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNKFCSITENKVL 549
++K H+++I+L +C +++ ++ E ++K ++L L + ++ Q+ +TE
Sbjct: 289 ILKKLRHKHLIALFAVCTSSSPFYIITELMEKG--DLLSLLKGKEGQDLNAQMLTE---- 342
Query: 550 QICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHL--RSLHETPDYT-- 605
+ QVA GM YL + +H+ L RN+++ N K+A GL+ + S++ + D
Sbjct: 343 -MASQVADGMAYLEEQNSIHRDLAARNVLVGANYICKVADLGLARIVKESVYSSEDAQIP 401
Query: 606 -RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRILRGMRPSQPS 664
+W++ E + R++ K+DVWSFGVL++E+ T G PY N +V + I G R P
Sbjct: 402 YKWSAPEAISHGRFSNKSDVWSFGVLLYEMFTYGGVPYPAFSNIEVYNMITSGYRMPAPP 461
Query: 665 YVGDELFQVCLQCWQVDPDERPTFSSLV 692
++ + L CW+ +ERP FS L+
Sbjct: 462 NCPSHIYDIMLMCWRYSAEERPDFSELL 489
>UniRef50_UPI0000DB6C99 Cluster: PREDICTED: similar to proto-oncogene
c-ros-1 protein precursor; n=1; Apis mellifera|Rep:
PREDICTED: similar to proto-oncogene c-ros-1 protein
precursor - Apis mellifera
Length = 2105
Score = 118 bits (283), Expect = 7e-25
Identities = 77/223 (34%), Positives = 114/223 (51%), Gaps = 18/223 (8%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNN 538
EK + LQE L+ H++V+ L+G+C L+VLE + + + L R +Q +
Sbjct: 1850 EKTEFLQEARLM-SHFRHKHVLRLLGVCLDTDPPLLVLE-LMEAGDLLSYLRASRSLQPS 1907
Query: 539 KFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIIS----ENGTVKIAGFGLSH 594
++ +L +C VARG YL VH+ L CRN ++S EN VKI FGL+
Sbjct: 1908 DSHALRLQDLLAMCEDVARGCRYLEELHFVHRDLACRNCLVSAKDRENRVVKIGDFGLA- 1966
Query: 595 LRSLHETPDY---------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHS 645
R +++ Y RW + E L + ++DVW+FGVLMWE+ +LG PY
Sbjct: 1967 -RDIYKNDYYRKEGEGLLPVRWMAPESLVDGVFTSQSDVWAFGVLMWEITSLGQQPYPAR 2025
Query: 646 GNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTF 688
N +V + G R S+P L Q+ L+CW D D RP+F
Sbjct: 2026 TNIEVLHHVRAGGRLSKPLNCPLALHQLMLRCWS-DVDTRPSF 2067
>UniRef50_Q2LC18 Cluster: Tyrosine-protein kinase receptor; n=2;
Strongylocentrotus purpuratus|Rep: Tyrosine-protein
kinase receptor - Strongylocentrotus purpuratus (Purple
sea urchin)
Length = 1072
Score = 118 bits (283), Expect = 7e-25
Identities = 64/229 (27%), Positives = 117/229 (51%), Gaps = 12/229 (5%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNN 538
++ + L E ++ K + NV+ L+G+ V++E + + + L +R+ + Q +
Sbjct: 744 DRIEFLNEASVM-KLIDAHNVVRLLGVVSKGQPTYVIMEFMAQGDLKNWLRARRPENQQD 802
Query: 539 KFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSL 598
T ++L + ++A GM +L RK VH+ L RN ++S GT K+A FGL+ R +
Sbjct: 803 LPSVPTLEQLLNMAAEIADGMSFLAARKYVHRDLSARNCLVSGEGTCKVADFGLA--RDI 860
Query: 599 HETPDYT---------RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKD 649
+++ Y RW + E ++ + +DVWSFG+L+WE+ TLG PY N++
Sbjct: 861 YQSDYYRKERGGMLPIRWMAPESVKDGVFQASSDVWSFGILLWEMATLGELPYQGLSNEE 920
Query: 650 VGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPF 698
G I G P +++ ++ + CWQ RP F +++ L +
Sbjct: 921 AGEYIKGGNVLRPPENCPEKMQEIMMACWQYQEKLRPLFGEIILNLQDY 969
>UniRef50_Q16RK6 Cluster: Receptor protein tyrosine kinase; n=1;
Aedes aegypti|Rep: Receptor protein tyrosine kinase -
Aedes aegypti (Yellowfever mosquito)
Length = 817
Score = 118 bits (283), Expect = 7e-25
Identities = 68/213 (31%), Positives = 116/213 (54%), Gaps = 17/213 (7%)
Query: 501 SLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQ----NNKFCSITENKVLQICVQVA 556
S I CE +T L V++E+ K + +S + D Q + I+ ++++ Q+A
Sbjct: 592 SPINSCEIDTDLPVMVEN--KLYQHQRRVSNEFDNQCYFGEEEKQPISSKQLIEFARQIA 649
Query: 557 RGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSLHETPDYTR---------W 607
GME+L ++VH+ L RN+++S+ TVKI+ FGLS R +++ Y + W
Sbjct: 650 YGMEFLARNRVVHRDLAARNILVSDGATVKISDFGLS--RDIYQENMYRKTTNGKLPIKW 707
Query: 608 TSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRILRGMRPSQPSYVG 667
+ E L Y ++DVWSFG++++E+ TLG PY ++ + G R +P+
Sbjct: 708 LALESLTHQVYTSQSDVWSFGIVLYEICTLGGNPYPMLETGNLLLELKAGYRMERPASCC 767
Query: 668 DELFQVCLQCWQVDPDERPTFSSLVIELTPFSE 700
+EL+++ L CW+ P ERPTFS++ +L E
Sbjct: 768 EELYELMLSCWRALPSERPTFSTVTNQLEKMIE 800
>UniRef50_P10447 Cluster: Tyrosine-protein kinase transforming
protein Abl; n=57; root|Rep: Tyrosine-protein kinase
transforming protein Abl - Feline sarcoma virus (strain
Hardy-Zuckerman 2)
Length = 439
Score = 118 bits (283), Expect = 7e-25
Identities = 63/219 (28%), Positives = 115/219 (52%), Gaps = 14/219 (6%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNN 538
E ++ L+E ++ K +H N++ L+G+C ++ E + T +L R+ + Q
Sbjct: 228 EVEEFLKEAAVM-KEIKHPNLVQLLGVCTREPPFYIITEFM--TYGNLLDYLRECNRQE- 283
Query: 539 KFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRS- 597
+ +L + Q++ MEYL + +H+ L RN ++ EN VK+A FGLS L +
Sbjct: 284 ----VNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTG 339
Query: 598 ----LHETPDYT-RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGS 652
H + +WT+ E L +++ K+DVW+FGVL+WE+ T G +PY V
Sbjct: 340 DTYTAHAGTKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYE 399
Query: 653 RILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSL 691
+ + R +P ++++++ CWQ +P +RP F+ +
Sbjct: 400 LLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPAFAEI 438
>UniRef50_P42684 Cluster: Tyrosine-protein kinase ABL2; n=38;
Euteleostomi|Rep: Tyrosine-protein kinase ABL2 - Homo
sapiens (Human)
Length = 1182
Score = 118 bits (283), Expect = 7e-25
Identities = 64/217 (29%), Positives = 112/217 (51%), Gaps = 14/217 (6%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNN 538
E ++ L+E ++ K +H N++ L+G+C +V E + LL R+
Sbjct: 325 EVEEFLKEAAVM-KEIKHPNLVQLLGVCTLEPPFYIVTE----YMPYGNLLDYLRECNRE 379
Query: 539 KFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRS- 597
+ ++ +L + Q++ MEYL + +H+ L RN ++ EN VK+A FGLS L +
Sbjct: 380 EVTAVV---LLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTG 436
Query: 598 ----LHETPDYT-RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGS 652
H + +WT+ E L ++ K+DVW+FGVL+WE+ T G +PY V
Sbjct: 437 DTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYD 496
Query: 653 RILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFS 689
+ +G R QP +++++ CW+ P +RP+F+
Sbjct: 497 LLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFA 533
>UniRef50_UPI0000DB72A0 Cluster: PREDICTED: similar to R151.4a; n=1;
Apis mellifera|Rep: PREDICTED: similar to R151.4a - Apis
mellifera
Length = 537
Score = 117 bits (282), Expect = 1e-24
Identities = 75/260 (28%), Positives = 133/260 (51%), Gaps = 37/260 (14%)
Query: 472 DRELEKTEKKQMLQELDLLIKTSEHENVISLIGIC-ETNTTLLVVLEDIKKTLKEMLLLS 530
D ++ ++Q +QE++++I H +++SLIG C + N + ++LE +K + L
Sbjct: 250 DLSIDSETRQQFIQEIEIMIMAGNHPHLVSLIGYCIKPNHPICILLEYMKGG-DLLTYLH 308
Query: 531 RQRDIQNNKF-----------CSITENKV----------------LQICVQVARGMEYLH 563
QR+ QN + C +K+ L+ ++A GME+L
Sbjct: 309 NQRNQQNKQMIYHDQNILQDLCETYVSKIKNENESWIGKMERHQFLKFAKEIAMGMEHLE 368
Query: 564 TRKIVHKKLCCRNMIISENGTVKIAGFGLSH-----LRSLHETPDYT--RWTSHEMLRQT 616
+ I H+ L RN++++E+ TVKI+ FGLS +++ E + RW S E L
Sbjct: 369 AKGITHRDLAARNILLTEDLTVKISDFGLSRNGVYVIKNTEEKTHHLPIRWMSPEALYNR 428
Query: 617 RYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRIL-RGMRPSQPSYVGDELFQVCL 675
++ K+DVWSFG+++WE+ TLG PY + + + I+ + R QP V ++++
Sbjct: 429 AFSSKSDVWSFGIVLWEISTLGGFPYCNIQDDHLLHYIVHKNGRLEQPDNVPSSIYKLMH 488
Query: 676 QCWQVDPDERPTFSSLVIEL 695
CW +P RP F+ L+ +L
Sbjct: 489 SCWATEPQNRPNFTQLLSKL 508
>UniRef50_UPI0000D57520 Cluster: PREDICTED: similar to CG8250-PA; n=1;
Tribolium castaneum|Rep: PREDICTED: similar to CG8250-PA
- Tribolium castaneum
Length = 1284
Score = 117 bits (282), Expect = 1e-24
Identities = 68/238 (28%), Positives = 117/238 (49%), Gaps = 18/238 (7%)
Query: 489 LLIKTSEHENVISLIGICETNTTLLVVLEDIKK-TLKEMLLLSRQRDIQNNKFCSITENK 547
L++ H N++ IG+C +VLE + LK L SR + + + +T
Sbjct: 873 LIMSKFNHPNIVHFIGVCFDKHPRFIVLELLAGGDLKNFLRESRPKPERGSP---LTMKD 929
Query: 548 VLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENG---TVKIAGFGLSHLRSLHETPDY 604
++ I V VA+G +YL + +H+ + RN +++ G VKIA FG+S R ++ + Y
Sbjct: 930 LVLIAVDVAKGCKYLEDNRFIHRDIAARNCLLTTKGPGRVVKIADFGMS--RDVYRSDYY 987
Query: 605 TR---------WTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRIL 655
+ W E + K DVWSFGVL+WE++++G PY+ N++V +
Sbjct: 988 RKGGKAMLPIKWMPPEAFLDGIFTSKTDVWSFGVLLWEIMSMGYMPYTGCANREVMQLVT 1047
Query: 656 RGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEAPGTRNLSFTHYN 713
G R P+ ++ + QCW P++RPTF++++ L + P N +N
Sbjct: 1048 SGGRLDPPANCPGPIYGIMTQCWHPTPEQRPTFATILERLGYCLQDPQVMNAPLPVFN 1105
>UniRef50_UPI0000ECD739 Cluster: Cytoplasmic tyrosine-protein kinase
BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in
chromosome X protein) (Epithelial and endothelial
tyrosine kinase) (ETK) (NTK38).; n=2; Gallus gallus|Rep:
Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2)
(Bone marrow tyrosine kinase gene in chromosome X
protein) (Epithelial and endothelial tyrosine kinase)
(ETK) (NTK38). - Gallus gallus
Length = 633
Score = 117 bits (282), Expect = 1e-24
Identities = 63/217 (29%), Positives = 115/217 (52%), Gaps = 15/217 (6%)
Query: 482 QMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNKFC 541
+ ++E ++K + H ++ L G+C + +V+E + L +++Q
Sbjct: 411 EFVEEAQTMMKLN-HPKLVRLYGVCSKLYPIYLVMEYMPNGSLLSYLQIHGKELQ----- 464
Query: 542 SITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSH--LRSLH 599
++L+IC V M +L + +++H+ L RN ++ N TVK++ FG++ L L+
Sbjct: 465 ---PLQLLEICYDVCDAMAFLESCQLIHRDLAARNCLVDSNLTVKLSDFGMTKYVLDDLY 521
Query: 600 ETPDYTR----WTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRIL 655
+ T+ W++ E+ T+++ K+DVW+FG+LMWEV TLG PY N V ++
Sbjct: 522 VSSLGTKFPVKWSAPEVFHYTKFSSKSDVWAFGILMWEVFTLGKQPYELYDNMQVIEKVS 581
Query: 656 RGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLV 692
+G R +P V D +Q+ CW P++RP F L+
Sbjct: 582 QGYRLYRPQLVSDITYQIMYNCWHELPEKRPAFHQLL 618
>UniRef50_Q4H3N2 Cluster: Epidermal growth factor receptor; n=1;
Ciona intestinalis|Rep: Epidermal growth factor receptor
- Ciona intestinalis (Transparent sea squirt)
Length = 878
Score = 117 bits (282), Expect = 1e-24
Identities = 71/237 (29%), Positives = 121/237 (51%), Gaps = 18/237 (7%)
Query: 474 ELEKTEKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQR 533
E + ++L E ++ + EH N++ L+GI + +L+ + + LL R
Sbjct: 164 ESSQVASNEILDEA-FVMASCEHPNLVRLLGISLSQRIMLIT-----QLMPLGNLLEYVR 217
Query: 534 DIQNNKFCSITENKVLQICVQVARGMEYLHTRK-IVHKKLCCRNMIISENGTVKIAGFGL 592
D ++N I +L +Q+A+GM+YL K +VH+ L RN+++ V+I FGL
Sbjct: 218 DNKDN----IGSQHLLNWSLQIAKGMKYLSEEKHLVHRDLAARNVLVKSPNHVRITDFGL 273
Query: 593 SHLRSLHETPDYT-------RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHS 645
+ L + E +W + E ++ + K+DVWSFGV MWE++T G PY
Sbjct: 274 AKLLDVKEDVYRAEGGKMPIKWLALESIQHRIFTQKSDVWSFGVTMWELMTFGKKPYESV 333
Query: 646 GNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEAP 702
++V + + RG R QP +++ + ++CW VD + RPTF L EL+ + P
Sbjct: 334 PAREVHTLLERGERLPQPYICTIDIYMLLIKCWTVDAEARPTFKELTEELSKLARDP 390
>UniRef50_Q13882 Cluster: Tyrosine-protein kinase 6; n=11;
Mammalia|Rep: Tyrosine-protein kinase 6 - Homo sapiens
(Human)
Length = 451
Score = 117 bits (282), Expect = 1e-24
Identities = 69/224 (30%), Positives = 117/224 (52%), Gaps = 12/224 (5%)
Query: 481 KQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNKF 540
+QMLQ +K H+++++L + + ++ E + K +L L R D K
Sbjct: 229 QQMLQSEIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKG--SLLELLRDSD---EKV 283
Query: 541 CSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHL--RSL 598
++E +L I QVA GM YL ++ +H+ L RN+++ EN K+ FGL+ L +
Sbjct: 284 LPVSE--LLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDV 341
Query: 599 HETPDYT---RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRIL 655
+ + D+ +WT+ E L + Y+ K+DVWSFG+L+ E+ + G PY N + R+
Sbjct: 342 YLSHDHNIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVD 401
Query: 656 RGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFS 699
G R P + ++ L CW DP++RP F +L L+ F+
Sbjct: 402 AGYRMPCPLECPPSVHKLMLTCWCRDPEQRPCFKALRERLSSFT 445
>UniRef50_UPI0000DB7735 Cluster: PREDICTED: similar to Insulin
receptor precursor (IR); n=1; Apis mellifera|Rep:
PREDICTED: similar to Insulin receptor precursor (IR) -
Apis mellifera
Length = 1374
Score = 117 bits (281), Expect = 1e-24
Identities = 67/226 (29%), Positives = 120/226 (53%), Gaps = 15/226 (6%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNN 538
EK L E++++ K EH+N+I L+G+C + +L V+E + + LL+R+ + +N
Sbjct: 984 EKLDFLSEVEVM-KQFEHKNIIKLLGVCIKSEPVLTVMEFMLYGDLKTYLLARRHLVNDN 1042
Query: 539 KF---CSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHL 595
+ I+ K+ + + VAR + YL K VH+ + RN +++ VK+ FG++ L
Sbjct: 1043 SYEDSDEISNKKLTAMALDVARALSYLAQSKYVHRDIASRNCLVNAQRVVKLGDFGMTRL 1102
Query: 596 RSLHETPDY---------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSG 646
++E Y RW + E L ++P +DVWS+GVL++E++T G+ P+
Sbjct: 1103 --MYENDYYKFNRRGMLPVRWMAPESLGLGIFSPASDVWSYGVLLYEIITFGSFPFQGMS 1160
Query: 647 NKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLV 692
N +V + + G P V +L + CW++D +RPT +V
Sbjct: 1161 NIEVLNHVKSGNSLMVPKGVKIQLENLMYSCWRLDHIKRPTAPEIV 1206
>UniRef50_Q10656-2 Cluster: Isoform b of Q10656 ; n=4;
Caenorhabditis|Rep: Isoform b of Q10656 - Caenorhabditis
elegans
Length = 988
Score = 117 bits (281), Expect = 1e-24
Identities = 72/242 (29%), Positives = 121/242 (50%), Gaps = 34/242 (14%)
Query: 483 MLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKK-TLKEMLLLSRQRDIQNNKFC 541
++ E++ EHENV+ LIG C L VV+E K L++ L R ++ + K
Sbjct: 634 LVSEMETFKVIGEHENVLRLIGCCTGAGPLYVVVELCKHGNLRDFLRAHRPKEEKAKKSS 693
Query: 542 ----------------------SITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMII 579
++T+ ++Q QVA+GM +L ++KI+H+ L RN+++
Sbjct: 694 QELTDYLEPRKASDKDDIELIPNLTQRHLVQFAWQVAQGMNFLASKKIIHRDLAARNVLV 753
Query: 580 SENGTVKIAGFGLSHLRSLHETPDYTR---------WTSHEMLRQTRYNPKADVWSFGVL 630
+ +KI+ FGLS R +H Y + W + E L Y ++DVWS+GVL
Sbjct: 754 GDGHVLKISDFGLS--RDVHCNDYYRKRGNGRLPIKWMALEALDSNVYTVESDVWSYGVL 811
Query: 631 MWEVLTLGATPYSHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSS 690
+WE++TLG TPY ++ + + G R P E++ + CW+ +ERP+F +
Sbjct: 812 LWEIMTLGGTPYPTIAMPELYANLKEGYRMEPPHLCPQEVYHLMCSCWREKLEERPSFKT 871
Query: 691 LV 692
+V
Sbjct: 872 IV 873
>UniRef50_Q259N0 Cluster: H0723C07.13 protein; n=4; Oryza
sativa|Rep: H0723C07.13 protein - Oryza sativa (Rice)
Length = 541
Score = 117 bits (281), Expect = 1e-24
Identities = 74/236 (31%), Positives = 122/236 (51%), Gaps = 21/236 (8%)
Query: 470 IADRELEKTEKKQMLQEL----DLLIKTSEHENVISLIGICETNTTLLVVLEDIKK-TLK 524
+ + + K + LQE+ +++ ++ +HENV+ G C + L+V E + L
Sbjct: 290 LRSEHVNDSSKVEFLQEIMILNEVMSRSVDHENVVQFYGACTKHRKYLIVTEYMPGGNLY 349
Query: 525 EMLLLSRQRDIQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGT 584
+ L QNN ++ VL+I + +++GM+YLH I+H+ L N++I
Sbjct: 350 DFL------HKQNN---TLELPVVLRIAIGISKGMDYLHQNNIIHRDLKTANLLIGSGQV 400
Query: 585 VKIAGFGLSHLRS-----LHETPDYTRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGA 639
VKIA FG+S LRS ET Y RW + E++ Y+ KADV+SF +++WE++T
Sbjct: 401 VKIADFGVSRLRSQGGEMTAETGTY-RWMAPEVINHKPYDHKADVFSFAIVLWELVTT-K 458
Query: 640 TPYSHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIEL 695
PY + + +GMR P V L ++ +CW +P RP FS + +EL
Sbjct: 459 IPYENLTPLQAALGVRQGMRMEIPPKVHPRLSKLIERCWDENPHVRPLFSEITVEL 514
>UniRef50_Q7Q0U2 Cluster: ENSANGP00000012311; n=1; Anopheles gambiae
str. PEST|Rep: ENSANGP00000012311 - Anopheles gambiae
str. PEST
Length = 410
Score = 117 bits (281), Expect = 1e-24
Identities = 56/147 (38%), Positives = 85/147 (57%), Gaps = 3/147 (2%)
Query: 554 QVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSLHETPDYT---RWTSH 610
Q+A GME+L I H+ L RN++I E T+KI+ FGLS T + RW S
Sbjct: 232 QIAFGMEHLEGLHITHRDLAARNILIDERKTLKISDFGLSRTGIYVNTRNKKVPLRWLSI 291
Query: 611 EMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRILRGMRPSQPSYVGDEL 670
E +R Y+ K+DVW+FG+++WE+ TLG PY N ++ + + G R +P ++
Sbjct: 292 EAMRDNLYSNKSDVWAFGIVLWEIGTLGGYPYPSVSNHELFAYLQEGKRLERPENCTVDV 351
Query: 671 FQVCLQCWQVDPDERPTFSSLVIELTP 697
+ + LQCW+ DP+ERP+F + L P
Sbjct: 352 YDLMLQCWREDPNERPSFQQISKHLQP 378
>UniRef50_O16131 Cluster: Insulin receptor homolog precursor; n=2;
Caenorhabditis elegans|Rep: Insulin receptor homolog
precursor - Caenorhabditis elegans
Length = 1846
Score = 117 bits (281), Expect = 1e-24
Identities = 77/245 (31%), Positives = 125/245 (51%), Gaps = 15/245 (6%)
Query: 478 TEKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKK-TLKEMLLLSRQRDIQ 536
TE L E +++ K + ++ L G+ T +VV+E + L++ L R+ ++
Sbjct: 1291 TENLNYLMEANIM-KNFKTNFIVQLYGVISTVQPAMVVMEMMDLGNLRDYLRSKREDEVF 1349
Query: 537 NNKFCS----ITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGL 592
N C+ I +K + Q+ GM YL + K H+ L RN +I+ + TVKI FG+
Sbjct: 1350 NETDCNFFDIIPRDKFHEWAAQICDGMAYLESLKFCHRDLAARNCMINRDETVKIGDFGM 1409
Query: 593 SHLRSLHE--TPDY-----TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHS 645
+ H+ P RW S E L+ +++ K+DVWSFGV+++E++TLGA PY
Sbjct: 1410 ARDLFYHDYYKPSGKRMMPVRWMSPESLKDGKFDSKSDVWSFGVVLYEMVTLGAQPYIGL 1469
Query: 646 GNKDVGSRILRGMRP-SQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEAPGT 704
N +V + I + +P + ++V CW+ P +RPTF LV L +P
Sbjct: 1470 SNDEVLNYIGMARKVIKKPECCENYWYKVMKMCWRYSPRDRPTFLQLV-HLLAAEASPEF 1528
Query: 705 RNLSF 709
R+LSF
Sbjct: 1529 RDLSF 1533
>UniRef50_P09208 Cluster: Insulin-like receptor precursor (EC
2.7.10.1) (DIR) (DInr) (dIRH) [Contains: Insulin-like
receptor subunit alpha; Insulin-like receptor subunit
beta 1; Insulin-like receptor subunit beta 2]; n=15;
Eumetazoa|Rep: Insulin-like receptor precursor (EC
2.7.10.1) (DIR) (DInr) (dIRH) [Contains: Insulin-like
receptor subunit alpha; Insulin-like receptor subunit
beta 1; Insulin-like receptor subunit beta 2] -
Drosophila melanogaster (Fruit fly)
Length = 2144
Score = 117 bits (281), Expect = 1e-24
Identities = 79/255 (30%), Positives = 128/255 (50%), Gaps = 25/255 (9%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKK-TLKEMLLLSR--QRDI 535
E+ L E ++ K + +V+ L+G+C LVV+E +KK LK L R +RD
Sbjct: 1415 ERTNFLSEASVM-KEFDTYHVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEERDE 1473
Query: 536 QNNKFCS---ITEN-------KVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTV 585
+ + +T N ++ Q+ +++A GM YL +K VH+ L RN +++++ TV
Sbjct: 1474 AMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTV 1533
Query: 586 KIAGFGLSHLRSLHETPDY---------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLT 636
KI FG++ R ++ET Y RW E LR Y+ +DV+SFGV++WE+ T
Sbjct: 1534 KIGDFGMT--RDIYETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMAT 1591
Query: 637 LGATPYSHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELT 696
L A PY N+ V ++ G +P D L ++ +CW RP+F ++ L
Sbjct: 1592 LAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYLE 1651
Query: 697 PFSEAPGTRNLSFTH 711
P + +SF H
Sbjct: 1652 PQCPNSQFKEVSFYH 1666
>UniRef50_Q10656 Cluster: Myoblast growth factor receptor egl-15
precursor; n=7; Caenorhabditis elegans|Rep: Myoblast
growth factor receptor egl-15 precursor - Caenorhabditis
elegans
Length = 1040
Score = 117 bits (281), Expect = 1e-24
Identities = 72/242 (29%), Positives = 121/242 (50%), Gaps = 34/242 (14%)
Query: 483 MLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKK-TLKEMLLLSRQRDIQNNKFC 541
++ E++ EHENV+ LIG C L VV+E K L++ L R ++ + K
Sbjct: 686 LVSEMETFKVIGEHENVLRLIGCCTGAGPLYVVVELCKHGNLRDFLRAHRPKEEKAKKSS 745
Query: 542 ----------------------SITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMII 579
++T+ ++Q QVA+GM +L ++KI+H+ L RN+++
Sbjct: 746 QELTDYLEPRKASDKDDIELIPNLTQRHLVQFAWQVAQGMNFLASKKIIHRDLAARNVLV 805
Query: 580 SENGTVKIAGFGLSHLRSLHETPDYTR---------WTSHEMLRQTRYNPKADVWSFGVL 630
+ +KI+ FGLS R +H Y + W + E L Y ++DVWS+GVL
Sbjct: 806 GDGHVLKISDFGLS--RDVHCNDYYRKRGNGRLPIKWMALEALDSNVYTVESDVWSYGVL 863
Query: 631 MWEVLTLGATPYSHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSS 690
+WE++TLG TPY ++ + + G R P E++ + CW+ +ERP+F +
Sbjct: 864 LWEIMTLGGTPYPTIAMPELYANLKEGYRMEPPHLCPQEVYHLMCSCWREKLEERPSFKT 923
Query: 691 LV 692
+V
Sbjct: 924 IV 925
>UniRef50_Q9FIL6 Cluster: Protein-tyrosine kinase; n=10; core
eudicotyledons|Rep: Protein-tyrosine kinase -
Arabidopsis thaliana (Mouse-ear cress)
Length = 525
Score = 116 bits (280), Expect = 2e-24
Identities = 76/237 (32%), Positives = 125/237 (52%), Gaps = 17/237 (7%)
Query: 480 KKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNK 539
+KQ +E+ LL + + H NVI +G + V+ + L E L S +N
Sbjct: 252 EKQFTKEVTLLSRLT-HPNVIKFVGAYKDPPVYCVLTQ----YLPEGSLRSFLHKPENR- 305
Query: 540 FCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLS----HL 595
S+ K+++ + +ARGMEY+H+R+I+H+ L N++I E +KIA FG++ +
Sbjct: 306 --SLPLKKLIEFAIDIARGMEYIHSRRIIHRDLKPENVLIDEEFHLKIADFGIACEEEYC 363
Query: 596 RSLHETPDYTRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRIL 655
L + P RW + EM+++ + KADV+SFG+++WE++ GA PY ++
Sbjct: 364 DMLADDPGTYRWMAPEMIKRKPHGRKADVYSFGLVLWEMVA-GAIPYEDMNPIQAAFAVV 422
Query: 656 -RGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFS---EAPGTRNLS 708
+ +RP+ P + + QCW V PD+RP F +V L F+ E G NLS
Sbjct: 423 HKNIRPAIPGDCPVAMKALIEQCWSVAPDKRPEFWQIVKVLEQFAISLEREGNLNLS 479
>UniRef50_O76698 Cluster: Vegf (Vascular endothelial growth factor)
receptor family protein 1; n=1; Caenorhabditis
elegans|Rep: Vegf (Vascular endothelial growth factor)
receptor family protein 1 - Caenorhabditis elegans
Length = 1083
Score = 116 bits (280), Expect = 2e-24
Identities = 68/227 (29%), Positives = 116/227 (51%), Gaps = 20/227 (8%)
Query: 480 KKQMLQELDLLIKTSEHENVISLIGICETNTT---LLVVLEDIKK-TLKEMLLLSRQ--- 532
+K +++EL L+ +H NV++L+G N L +++E I L++ L R
Sbjct: 843 QKVIVEELKLMSAIPKHPNVLALVGAITKNLRHGELYILMEYIDGGNLRDFLQQRRNVFI 902
Query: 533 RDIQNN----------KFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISEN 582
++ +N F S++ ++ I Q+A GME+L VH LCCR ++IS+
Sbjct: 903 DELHDNFDENIPLIRPDFNSLSTTDLVGIAHQIANGMEWLGNVPCVHGNLCCRKVLISKT 962
Query: 583 GTVKIAGFGLSHLRSLHETPDYTRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPY 642
T++I +G+ + + RW + E + ++ K+DVWSFG+ ++E+ TLG TPY
Sbjct: 963 KTIRITDYGVGDRQRKSSS---MRWMAPEAIEHQMFSSKSDVWSFGICLYEIFTLGGTPY 1019
Query: 643 SHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFS 689
+++ I G R QP Y L+ + CW+ P +RP FS
Sbjct: 1020 PTCVTENILKHIKNGSRNLQPEYCPSALYDLMQLCWRAPPQDRPKFS 1066
>UniRef50_Q27324 Cluster: Tyrosine-protein kinase Drl precursor;
n=2; Sophophora|Rep: Tyrosine-protein kinase Drl
precursor - Drosophila melanogaster (Fruit fly)
Length = 610
Score = 116 bits (280), Expect = 2e-24
Identities = 76/225 (33%), Positives = 119/225 (52%), Gaps = 16/225 (7%)
Query: 483 MLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNKFC- 541
+LQE +L + S H NV+S++GI + VL +++ + + +Q+ +
Sbjct: 385 LLQESMMLYEAS-HPNVLSVLGISIEDYATPFVLYAATGSVRNL-----KSFLQDPSYAR 438
Query: 542 SITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSH------L 595
S+T + + + Q+A ME+LH ++HK + RN +I + VK+ LS
Sbjct: 439 SVTTIQTVLMGSQLAMAMEHLHNHGVIHKDIAARNCVIDDQLRVKLTDSALSRDLFPGDY 498
Query: 596 RSLHETPDY--TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSR 653
SL + +Y +W S E L+++ YN +DVWSFGVLMWE+ TLG PY+ ++
Sbjct: 499 NSLGD-GEYRPIKWLSLEALQKSHYNEGSDVWSFGVLMWEMCTLGKLPYAEIDPYEMEHY 557
Query: 654 ILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPF 698
+ G R +QP DELF + CW P ERP+FS L I L+ F
Sbjct: 558 LKDGYRLAQPFNCPDELFTIMAYCWASMPAERPSFSQLQICLSEF 602
>UniRef50_UPI0000D57494 Cluster: PREDICTED: similar to insulin
receptor; n=1; Tribolium castaneum|Rep: PREDICTED:
similar to insulin receptor - Tribolium castaneum
Length = 1351
Score = 116 bits (279), Expect = 2e-24
Identities = 68/226 (30%), Positives = 116/226 (51%), Gaps = 16/226 (7%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNN 538
E+ + L E ++ K + +V+ L+G+ LV++E + + L S + D +
Sbjct: 1023 ERLEFLNEASVM-KAFDTAHVVRLLGVVSQGQPTLVIMELMANGDLKTYLRSHRPDAEVY 1081
Query: 539 KFCSI----TENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSH 594
+ T ++LQ+ +++A GM YL +K VH+ L RN +++E+ TVKI FG++
Sbjct: 1082 DPATAKQPPTLKQILQMAIEIADGMAYLSAKKFVHRDLAARNCMVAEDLTVKIGDFGMT- 1140
Query: 595 LRSLHETPDY---------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHS 645
R ++ET Y RW + E L+ + +DVWS+GV++WE+ TL + PY
Sbjct: 1141 -RDIYETDYYRKGTKGLLPVRWMAPESLKDGVFTSNSDVWSYGVVLWEMATLASQPYQGL 1199
Query: 646 GNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSL 691
N V ++ G +P D+L+ + CWQ P RP+F L
Sbjct: 1200 SNDQVLRYVIDGGVMERPENCPDKLYTLMRYCWQHKPSARPSFLKL 1245
>UniRef50_Q1HTP2 Cluster: Tyrosine-protein kinase receptor; n=4;
Percomorpha|Rep: Tyrosine-protein kinase receptor -
Haplochromis burtoni (Burton's mouthbrooder)
Length = 1024
Score = 116 bits (279), Expect = 2e-24
Identities = 56/160 (35%), Positives = 94/160 (58%), Gaps = 12/160 (7%)
Query: 546 NKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSLHETPDYT 605
N ++ Q+ + M++L +RK VH+ L RN+++ E VK+ FGL+ R L + DY
Sbjct: 744 NDLISFSYQIVQAMDFLSSRKCVHRDLAARNILVCEGKLVKVCDFGLA--RDLLKDQDYI 801
Query: 606 ---------RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSH-SGNKDVGSRIL 655
+W S E + Q Y+ ++DVWS+GVL+WE+ +LG +PY ++ S +
Sbjct: 802 ARGNSFLPLKWMSPESIFQNIYSSQSDVWSYGVLLWEIFSLGCSPYPDLPMTQEFYSALK 861
Query: 656 RGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIEL 695
RG R S+P + ++++ V +CW+ P RP+FSSL+I +
Sbjct: 862 RGYRMSRPDHAPEDMYDVMKRCWEEKPQSRPSFSSLLITM 901
>UniRef50_Q9GRH2 Cluster: Tyrosine-protein kinase receptor; n=1;
Sycon raphanus|Rep: Tyrosine-protein kinase receptor -
Sycon raphanus
Length = 616
Score = 116 bits (279), Expect = 2e-24
Identities = 82/253 (32%), Positives = 129/253 (50%), Gaps = 33/253 (13%)
Query: 490 LIKTSEHENVISLIGICETNTTLLVVLE-----DIKKTLKEMLLLSRQRDIQ----NNKF 540
++K + V+ L+G+ T LVV+E D++ +++ +RQ I N
Sbjct: 269 IMKKFDSPYVMRLMGLVSTENKPLVVMEFMAEGDLRGYVRKCRPQNRQFSINSIETNGSA 328
Query: 541 CSI----TENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLR 596
S+ T + + +Q+++GM Y+H + VH+ L RN ++S N T+KI FG + R
Sbjct: 329 ASVYGIPTAERFMLWALQLSKGMAYVHEKHFVHRDLAARNCMLSSNLTLKIGDFGFT--R 386
Query: 597 SLHETPDY---------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGN 647
++E+ Y RW E LR Y P++DVWS+GV++WE+ TLG PY N
Sbjct: 387 DIYESDYYRKTGKGALPVRWMGPEALRDGMYIPESDVWSYGVVLWEMATLGDQPYKGKSN 446
Query: 648 KDVGSRILRGMRPSQPSYVGDELFQVCLQ----CWQVDPDERPTFSSLV--IELTPFSE- 700
++V S ++ G P + D Q CL CWQ P ERPTF +V ++ +P+ +
Sbjct: 447 EEVISLVIAGDHMPLPITLHD-FPQPCLDLMETCWQFQPAERPTFEKIVSMLDDSPYQDP 505
Query: 701 APGT-RNLSFTHY 712
GT R S HY
Sbjct: 506 LAGTLRFYSVFHY 518
>UniRef50_Q4H3N3 Cluster: Epidermal growth factor receptor; n=1; Ciona
intestinalis|Rep: Epidermal growth factor receptor -
Ciona intestinalis (Transparent sea squirt)
Length = 1462
Score = 116 bits (279), Expect = 2e-24
Identities = 60/168 (35%), Positives = 94/168 (55%), Gaps = 7/168 (4%)
Query: 542 SITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSLHET 601
SI ++L CVQ+A+GM+YL + +VH+ L RN+++ VKI FGL+ + E
Sbjct: 938 SIRSRQILSWCVQIAKGMKYLEEKHLVHRDLAARNVLVKTPNHVKITDFGLAKMLDTKEE 997
Query: 602 PDYT-------RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRI 654
+ +W + E + + ++ +DVW+FGV WE+LT GA PY DV S +
Sbjct: 998 IYHAEGGKLPIKWLAIECITEREFSHLSDVWAFGVTCWELLTFGARPYEGVRAVDVLSLL 1057
Query: 655 LRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEAP 702
RG R QP+ +++ V ++CW VD RP+FS+LV E + + P
Sbjct: 1058 ERGDRLPQPATSTIDIYMVLVKCWMVDRLCRPSFSNLVDEFSKMAADP 1105
>UniRef50_Q26566 Cluster: Epidermal growth factor receptor precursor;
n=5; Schistosoma|Rep: Epidermal growth factor receptor
precursor - Schistosoma mansoni (Blood fluke)
Length = 1717
Score = 116 bits (279), Expect = 2e-24
Identities = 70/241 (29%), Positives = 115/241 (47%), Gaps = 17/241 (7%)
Query: 471 ADRELEKTEKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLS 530
A R + +++LQE ++ H + + LIGIC ++ +V E+ L
Sbjct: 1093 AKRASVRANIEELLQEAKIMASVM-HRHCLPLIGICLSSERHCLV-----SIFVELGALD 1146
Query: 531 RQRDIQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGF 590
R ++ S+T +L Q+A GM YL R I+H+ L RN+++ V+I F
Sbjct: 1147 RYVKQHADELNSLT---LLSWAEQIADGMSYLEMRGIIHRDLAARNVLVQTREHVQITDF 1203
Query: 591 GLSHLRSLHETPDYT--------RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPY 642
GL+ + + RW + E L+ Y+ K DVWS+GV +WE+ T G PY
Sbjct: 1204 GLAKMLERRDEDSVIVKAGRVPIRWLAIETLQYGIYSHKTDVWSYGVTLWEIFTFGKRPY 1263
Query: 643 SHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEAP 702
D+ +++G R +QP +++ V ++CW D + RPTF L+ F + P
Sbjct: 1264 EDVDTVDIKDHVIKGGRLTQPDICTLDVYMVLVKCWMEDYESRPTFIELMRTFNTFCKTP 1323
Query: 703 G 703
G
Sbjct: 1324 G 1324
>UniRef50_UPI0000DB7330 Cluster: PREDICTED: similar to Ack
CG14992-PA; n=1; Apis mellifera|Rep: PREDICTED: similar
to Ack CG14992-PA - Apis mellifera
Length = 1302
Score = 116 bits (278), Expect = 3e-24
Identities = 67/217 (30%), Positives = 111/217 (51%), Gaps = 20/217 (9%)
Query: 490 LIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNKFCSITENKVL 549
++ T +H+N+I L G+ + ++V E+ L D + I+ +
Sbjct: 162 VMHTLDHQNLIRLYGVVLSQPMMMVT---------ELASLGALLDYLRKQCGQISVLTLC 212
Query: 550 QICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGL---------SHLRSLHE 600
+QVA GM YL ++ +H+ L CRN+++S VKI FGL ++ S H+
Sbjct: 213 DYALQVATGMAYLEAKRFLHRDLACRNVLLSSIDKVKIGDFGLMRALPQQEDCYVMSEHK 272
Query: 601 TPDYTRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRI-LRGMR 659
+ W + E L++ ++ +DVW FGV +WE+LT G P+ ++ +I G R
Sbjct: 273 KVPFP-WCAPESLKRRKFTHASDVWMFGVTLWEMLTFGEEPWVGLKGSEILRKIDKEGER 331
Query: 660 PSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELT 696
+P E++Q+ L+CW DP ERPTF+SL + LT
Sbjct: 332 LHEPEATPPEMYQLMLRCWACDPSERPTFASLRVSLT 368
>UniRef50_UPI0000D569CE Cluster: PREDICTED: similar to CG10023-PA,
isoform A; n=1; Tribolium castaneum|Rep: PREDICTED:
similar to CG10023-PA, isoform A - Tribolium castaneum
Length = 1106
Score = 116 bits (278), Expect = 3e-24
Identities = 81/300 (27%), Positives = 147/300 (49%), Gaps = 28/300 (9%)
Query: 406 NSGFILEDE--ERVDYYGNLKR---KLWNIPRNLIETDISCVVGVGTYXXXXXXXXXXXX 460
N+G +L ++ E VD G+ K + + R+ I+ + ++G G +
Sbjct: 394 NTGTMLSEDYAEIVDEEGDYSTPATKSYELQRDQIQ--LGEILGEGQFGDVHKGTYKAKD 451
Query: 461 XXXXXXXXXIADRELEKTEKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIK 520
RE + ++ L+E ++ K +H+++I LIG+C + + + +V+E K
Sbjct: 452 GSLIPVAVKTCKREADLNTTEKFLEEAYIMQKF-DHQHIIKLIGVC-SESPVWIVMELAK 509
Query: 521 KTLKEMLLLSRQRDIQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIIS 580
L E+ + +QNNK + +L Q++ + YL ++K VH+ + RN+++S
Sbjct: 510 --LGEL-----RAYLQNNKD-DLDLATLLLYAFQLSTALSYLESKKFVHRDIAARNVLVS 561
Query: 581 ENGTVKIAGFGLSHLRSLHETPDY---------TRWTSHEMLRQTRYNPKADVWSFGVLM 631
+ +VK+ FGLS RS+++ Y +W S E + R+ +DVW FGV M
Sbjct: 562 SHTSVKLGDFGLS--RSMNDDQSYYKASKGKLPIKWMSPESINFRRFTIASDVWMFGVCM 619
Query: 632 WEVLTLGATPYSHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSL 691
WE+L G P+ N +V ++I G R + P L+ + QCW +P +RP+F +
Sbjct: 620 WEILMYGIKPFQGVKNNEVLTKIENGERLALPPNCPPRLYSLMSQCWSYEPSKRPSFKEI 679
>UniRef50_Q910A2 Cluster: Spleen protein tyrosine kinase; n=2; Danio
rerio|Rep: Spleen protein tyrosine kinase - Danio rerio
(Zebrafish) (Brachydanio rerio)
Length = 586
Score = 116 bits (278), Expect = 3e-24
Identities = 72/220 (32%), Positives = 114/220 (51%), Gaps = 23/220 (10%)
Query: 480 KKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNK 539
K +ML+E +++ + ++ ++ +IGICE +LV+ L E+ L + +Q NK
Sbjct: 365 KDEMLREANVM-QQLDNPYIVRMIGICEAENLMLVM------ELAELGPL--HKFLQKNK 415
Query: 540 FCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSLH 599
IT + ++ QV+ GM+YL VH+ L RN+++ KI+ FGLS ++L
Sbjct: 416 H--ITVKNLTELVHQVSMGMKYLEEHNFVHRDLAARNVLLVTQHYAKISDFGLS--KALT 471
Query: 600 ETPDY----------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKD 649
E +Y +W + E + +++ K+DVWSFGVLMWE + G PY +
Sbjct: 472 EDENYYKAKGHGKWPLKWYAPECMNYLKFSSKSDVWSFGVLMWEAFSYGQKPYKGMKGNE 531
Query: 650 VGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFS 689
V I G R S P E++ + +CW PDERP FS
Sbjct: 532 VIQMIENGQRMSAPPDCPPEMYDLMKKCWTYKPDERPGFS 571
>UniRef50_Q5G254 Cluster: Erbb3; n=6; Danio rerio|Rep: Erbb3 - Danio
rerio (Zebrafish) (Brachydanio rerio)
Length = 1429
Score = 116 bits (278), Expect = 3e-24
Identities = 70/245 (28%), Positives = 125/245 (51%), Gaps = 23/245 (9%)
Query: 470 IADRELEKTEKKQMLQELD---LLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEM 526
+A + ++ +Q E+ L + + +H ++ LIGIC + L+ +L +
Sbjct: 740 VAIKTIQNRSSRQTFTEITDHMLSMGSLDHPYIVRLIGICPGASLQLITQLSPHGSLLQH 799
Query: 527 LLLSRQRDIQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVK 586
L + +D S+ ++L CVQ+A+GM YL + H+ L RN+++ + V+
Sbjct: 800 L--RQHKD-------SLDPQRLLNWCVQIAKGMYYLEEHCMAHRNLAARNILLKSDYIVQ 850
Query: 587 IAGFGLSHLR---------SLHETPDYTRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTL 637
I+ FG++ L S H+T +W + E + RY ++DVWS+GV +WE+++
Sbjct: 851 ISDFGVADLLYPDDKKYVYSEHKTS--IKWMALESILFGRYTHQSDVWSYGVTVWEMMSY 908
Query: 638 GATPYSHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTP 697
GA PY+ DV + +G R +QP +++ V ++CW +D + RPTF L E T
Sbjct: 909 GAEPYASMHPHDVPGLLEKGERLAQPQICTIDVYMVMVKCWMIDENVRPTFKELASEFTR 968
Query: 698 FSEAP 702
+ P
Sbjct: 969 MARDP 973
>UniRef50_P06213 Cluster: Insulin receptor precursor (EC 2.7.10.1)
(IR) (CD220 antigen) [Contains: Insulin receptor subunit
alpha; Insulin receptor subunit beta]; n=100;
Euteleostomi|Rep: Insulin receptor precursor (EC
2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin
receptor subunit alpha; Insulin receptor subunit beta] -
Homo sapiens (Human)
Length = 1382
Score = 116 bits (278), Expect = 3e-24
Identities = 71/243 (29%), Positives = 122/243 (50%), Gaps = 14/243 (5%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNN 538
E+ + L E ++ + H +V+ L+G+ LVV+E + + L S + + +NN
Sbjct: 1067 ERIEFLNEASVMKGFTCH-HVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENN 1125
Query: 539 KFCSI-TENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRS 597
T +++Q+ ++A GM YL+ +K VH+ L RN +++ + TVKI FG++ R
Sbjct: 1126 PGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMT--RD 1183
Query: 598 LHETPDY---------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNK 648
++ET Y RW + E L+ + +D+WSFGV++WE+ +L PY N+
Sbjct: 1184 IYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNE 1243
Query: 649 DVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEAPGTRNLS 708
V ++ G QP + + + CWQ +P RPTF ++ L P +S
Sbjct: 1244 QVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLE-IVNLLKDDLHPSFPEVS 1302
Query: 709 FTH 711
F H
Sbjct: 1303 FFH 1305
>UniRef50_Q16620 Cluster: BDNF/NT-3 growth factors receptor
precursor; n=73; Gnathostomata|Rep: BDNF/NT-3 growth
factors receptor precursor - Homo sapiens (Human)
Length = 822
Score = 115 bits (277), Expect = 4e-24
Identities = 66/232 (28%), Positives = 113/232 (48%), Gaps = 16/232 (6%)
Query: 473 RELEKTEKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQ 532
++ +K +E +LL +HE+++ G+C L++V E +K L +
Sbjct: 575 KDASDNARKDFHREAELLTNL-QHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHG 633
Query: 533 RDI----QNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIA 588
D + N +T++++L I Q+A GM YL ++ VH+ L RN ++ EN VKI
Sbjct: 634 PDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIG 693
Query: 589 GFGLSHLRSLHETPDYT---------RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGA 639
FG+S R ++ T Y RW E + ++ ++DVWS GV++WE+ T G
Sbjct: 694 DFGMS--RDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGK 751
Query: 640 TPYSHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSL 691
P+ N +V I +G +P E++++ L CWQ +P R +
Sbjct: 752 QPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGI 803
>UniRef50_Q91987 Cluster: BDNF/NT-3 growth factors receptor
precursor; n=17; Euteleostomi|Rep: BDNF/NT-3 growth
factors receptor precursor - Gallus gallus (Chicken)
Length = 818
Score = 115 bits (277), Expect = 4e-24
Identities = 66/226 (29%), Positives = 112/226 (49%), Gaps = 16/226 (7%)
Query: 473 RELEKTEKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQ 532
++ +K +E +LL +HE+++ G+C L++V E +K L +
Sbjct: 571 KDASDNARKDFHREAELLTNL-QHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHG 629
Query: 533 RDI----QNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIA 588
D + N+ +T++++L I Q+A GM YL ++ VH+ L RN ++ EN VKI
Sbjct: 630 PDAVLMAEGNRPAELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIG 689
Query: 589 GFGLSHLRSLHETPDYT---------RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGA 639
FG+S R ++ T Y RW E + ++ ++DVWS GV++WE+ T G
Sbjct: 690 DFGMS--RDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGK 747
Query: 640 TPYSHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDER 685
P+ N +V I +G +P E++ + L CWQ +P R
Sbjct: 748 QPWYQLSNNEVIECITQGRVLQRPRTCPKEVYDLMLGCWQREPHMR 793
>UniRef50_Q93105 Cluster: Insulin-like receptor precursor (EC
2.7.10.1) (MIR) [Contains: Insulin-like receptor alpha
chain; Insulin-like receptor beta chain]; n=2; Aedes
aegypti|Rep: Insulin-like receptor precursor (EC
2.7.10.1) (MIR) [Contains: Insulin-like receptor alpha
chain; Insulin-like receptor beta chain] - Aedes aegypti
(Yellowfever mosquito)
Length = 1390
Score = 115 bits (277), Expect = 4e-24
Identities = 70/242 (28%), Positives = 128/242 (52%), Gaps = 15/242 (6%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKK-TLKEMLLLSR-QRDIQ 536
EK L E ++ + + H +V+ L+G+ LV++E + LK L R +++
Sbjct: 1069 EKDSFLLEASVMKQFNTH-HVVRLLGVVSQGDPTLVIMELMANGDLKSYLRRHRPDYEMR 1127
Query: 537 NNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLR 596
+ T +++Q+ +++A G+ L +K VH+ L RN +++++ TVKI FG++ R
Sbjct: 1128 RSIRQPPTLRQIIQMAIEIADGIGVLSAKKFVHRDLAARNCMVADDMTVKIGDFGMT--R 1185
Query: 597 SLHETPDY---------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGN 647
++ET Y RW + E L+ ++ +DV+S+GV++WE+ TL + PY N
Sbjct: 1186 DIYETDYYRKGTKGFLPVRWMAPESLKDGIFSSSSDVFSYGVVLWEMATLASQPYQGLTN 1245
Query: 648 KDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEAPGTRNL 707
V ++ G +P D L+ + +CWQ P RPTF ++ EL P +P +++
Sbjct: 1246 DQVLRYVIDGGVMERPENCPDNLYNLMRRCWQHRPTARPTFMEIISELLP-DASPHFQDV 1304
Query: 708 SF 709
+F
Sbjct: 1305 AF 1306
>UniRef50_Q39886 Cluster: Protein kinase; n=7; Magnoliophyta|Rep:
Protein kinase - Glycine max (Soybean)
Length = 462
Score = 115 bits (276), Expect = 5e-24
Identities = 68/227 (29%), Positives = 119/227 (52%), Gaps = 14/227 (6%)
Query: 480 KKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNK 539
+KQ ++E+ LL + H+NVI C ++ E L E L + +++
Sbjct: 201 EKQFIREVTLLSRL-HHQNVIKFSAACRKPPVYCIITE----YLAEGSLRAYLHKLEHQ- 254
Query: 540 FCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRS-- 597
+I+ K++ + +ARGMEY+H++ ++H+ L N++I+E+ +KIA FG++ +
Sbjct: 255 --TISLQKLIAFALDIARGMEYIHSQGVIHRDLKPENILINEDNHLKIADFGIACEEASC 312
Query: 598 --LHETPDYTRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRIL 655
L + P RW + EM+++ Y K DV+SFG+++WE+LT G PY ++
Sbjct: 313 DLLADDPGTYRWMAPEMIKRKSYGKKVDVYSFGLILWEMLT-GTIPYEDMNPIQAAFAVV 371
Query: 656 -RGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEA 701
+ RP PS + + QCW + PD+RP F +V L F +
Sbjct: 372 NKNSRPIIPSNCPPAMRALIEQCWSLQPDKRPEFWQVVKILEQFESS 418
>UniRef50_O76695 Cluster: Vegf (Vascular endothelial growth factor)
receptor family protein 2; n=1; Caenorhabditis
elegans|Rep: Vegf (Vascular endothelial growth factor)
receptor family protein 2 - Caenorhabditis elegans
Length = 518
Score = 115 bits (276), Expect = 5e-24
Identities = 56/154 (36%), Positives = 94/154 (61%), Gaps = 11/154 (7%)
Query: 540 FCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSLH 599
F S++ + +L I +Q+A GME+L + VH+ L CRN++I++ ++IA FGL+ + ++
Sbjct: 130 FDSLSTSDLLSIGLQIATGMEWLASVPCVHRDLACRNVLITKTKIIRIADFGLTKIPTM- 188
Query: 600 ETPDYTRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGN-KDVGSRILRGM 658
S E + ++ K+DVWSFG+ ++E+ TLG TPY + G+ ++V I G
Sbjct: 189 ---------SSEAIDDLKFTEKSDVWSFGLCLYEIFTLGGTPYPNCGSIQEVIEFIENGN 239
Query: 659 RPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLV 692
R +QP Y DE++++ CW+ P +RPTF V
Sbjct: 240 RNAQPKYCPDEIYKLMKMCWKTSPKKRPTFKECV 273
>UniRef50_UPI00015B5971 Cluster: PREDICTED: similar to leukocyte
receptor tyrosine protein kinase; n=1; Nasonia
vitripennis|Rep: PREDICTED: similar to leukocyte receptor
tyrosine protein kinase - Nasonia vitripennis
Length = 1472
Score = 114 bits (275), Expect = 7e-24
Identities = 68/238 (28%), Positives = 118/238 (49%), Gaps = 18/238 (7%)
Query: 489 LLIKTSEHENVISLIGICETNTTLLVVLEDIKK-TLKEMLLLSRQRDIQNNKFCSITENK 547
L++ EH N++ IGI +VLE + LK L R R ++ ++T
Sbjct: 971 LIMSKFEHPNIVQFIGISFDKHPRYIVLELLAGGDLKNFLREERPRP---DRPTTLTMQS 1027
Query: 548 VLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENG---TVKIAGFGLSHLRSLHETPDY 604
++ VA+G +Y+ + +H+ + RN ++S G VKIA FG++ R ++ + Y
Sbjct: 1028 LIMCAYDVAKGCKYMEEARFIHRDIAARNCLLSCKGPGRVVKIADFGMA--RDIYRSDYY 1085
Query: 605 TR---------WTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRIL 655
+ W E + K DVW+FGVL+WE+++ G PY+ N++V S +
Sbjct: 1086 RKGGKAMLPIKWMPPESFLDGIFTTKTDVWAFGVLLWEIMSFGYMPYTGCANREVMSMVT 1145
Query: 656 RGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEAPGTRNLSFTHYN 713
G R +P+ D ++ + +CW P+ERP+FSS+V + + P N +Y+
Sbjct: 1146 SGGRLERPAGCPDPIYGIMTRCWHPHPEERPSFSSIVERIGYCLQDPDVINHPTPNYD 1203
>UniRef50_UPI0000D5603D Cluster: PREDICTED: similar to Insulin
receptor precursor (IR); n=1; Tribolium castaneum|Rep:
PREDICTED: similar to Insulin receptor precursor (IR) -
Tribolium castaneum
Length = 1293
Score = 114 bits (275), Expect = 7e-24
Identities = 77/276 (27%), Positives = 126/276 (45%), Gaps = 15/276 (5%)
Query: 428 WNIPRNLIETDISCVVGVGTYXXXXXXXXXXXXXXXXXXXXXIADRELEKTEKKQMLQEL 487
W IPRN + I+ +G G + EK L E
Sbjct: 894 WEIPRNSVV--INRKLGEGAFGTVYGGEANFPDKGWVAVAVKTLKVGSSTEEKLDFLSEA 951
Query: 488 DLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNKFCS----I 543
+++ K +H+N+I L+G+C + ++E + + LL+R R + N+K I
Sbjct: 952 EVM-KRFDHKNIIKLLGVCTKEEPIYTIMEFMLYGDLKTFLLAR-RHLVNDKTIEESDEI 1009
Query: 544 TENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSLHETPD 603
+ K+ + + VARG+ YL K VH+ + RN +I+ VK+A FG++ ++
Sbjct: 1010 SSKKLTMMALDVARGLSYLAQLKYVHRDVASRNCLINAQRIVKLADFGMTRPMFENDYYK 1069
Query: 604 YTR-------WTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRILR 656
+TR W S E L + P +DVWS+GVL++E++T G+ PY N +V +
Sbjct: 1070 FTRKGMLPVRWMSPESLALGVFTPSSDVWSYGVLLYEIITFGSFPYQGMTNGEVLEYVKN 1129
Query: 657 GMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLV 692
G + P V +L + CW DP R S +V
Sbjct: 1130 GHTVTIPQGVKTQLRGLLKSCWHQDPKMRTRASEIV 1165
>UniRef50_A1IKE0 Cluster: Receptor tyrosine kinase-like orphan
receptor; n=2; Nematostella vectensis|Rep: Receptor
tyrosine kinase-like orphan receptor - Nematostella
vectensis
Length = 715
Score = 114 bits (275), Expect = 7e-24
Identities = 65/208 (31%), Positives = 106/208 (50%), Gaps = 11/208 (5%)
Query: 495 EHENVISLIGICETNTTLLVVLEDIKK-TLKEMLLLSRQRD---IQNNKFCSITENKVLQ 550
+H N+I+++G+C + V+ E ++ TL E L+ + D + + + ++
Sbjct: 499 QHPNIITIVGMCNKSVPTCVLYEYLEYGTLHEYLVRNAPIDDPEAEEEIADPLWCDGLIS 558
Query: 551 ICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHL-------RSLHETPD 603
I QVA GM YL + IVH L RN ++ TVKI L+ L R LH P
Sbjct: 559 IAYQVAAGMNYLSSNNIVHGDLATRNCMVGPGRTVKITDVALTRLGYSHDYYRQLHRRPL 618
Query: 604 YTRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRILRGMRPSQP 663
RW + E + R+ P+ D+WSFGVL+WE+ + GA P+ N+DV R+ + P
Sbjct: 619 PVRWMAPEAILSYRFTPETDIWSFGVLLWELFSYGAQPHFGFSNEDVMFRLRECILLPCP 678
Query: 664 SYVGDELFQVCLQCWQVDPDERPTFSSL 691
++++ +CW + P RP FS++
Sbjct: 679 VDCPASVYRLMKECWDILPPSRPRFSTI 706
>UniRef50_Q7T6Y2 Cluster: Putative serine/threonine-protein
kinase/receptor R831 precursor; n=1; Acanthamoeba
polyphaga mimivirus|Rep: Putative
serine/threonine-protein kinase/receptor R831 precursor -
Mimivirus
Length = 1624
Score = 114 bits (275), Expect = 7e-24
Identities = 72/233 (30%), Positives = 120/233 (51%), Gaps = 15/233 (6%)
Query: 473 RELEKTEKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQ 532
++L +T+ + E+ L + +H N+++ IG C + +V E ++ +
Sbjct: 1396 QKLSETQLLEFRAEMAFLSEL-KHSNIVTFIGACIKKPNICIVTEYMR--------MGNL 1446
Query: 533 RDIQNNKFCSITENKVLQICVQVARGMEYLHTRK--IVHKKLCCRNMIISENGTVKIAGF 590
RD+ N IT L++ A G++YLH+ IVH+ + N+++ E+ VKIA F
Sbjct: 1447 RDVLKNPDIKITFANKLKLLYGAAMGIDYLHSSNPMIVHRDIKPANILVDEHFNVKIADF 1506
Query: 591 GLSHLRSLHETPDYTR---WTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGN 647
G + ++ + T WT+ E++R +Y KADV+SFGV+MWEVLT G P++
Sbjct: 1507 GFARIKEDNTTMTRCGTPCWTAPEVIRGEKYCEKADVFSFGVVMWEVLT-GKEPFAECNF 1565
Query: 648 KDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSE 700
V IL G RP PS E ++ +CW +RPT + +V +L +E
Sbjct: 1566 MKVSLDILEGGRPIIPSDCPHEFAKLIKKCWHAKAHKRPTMTEVVQQLMLITE 1618
Score = 76.6 bits (180), Expect = 2e-12
Identities = 61/242 (25%), Positives = 112/242 (46%), Gaps = 25/242 (10%)
Query: 470 IADRELEKTEKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLL 529
I+ + + K ++ +E+ ++ H NV+ + + + +V+E + L
Sbjct: 815 ISSKHVSKDMERSFFEEVKIMTSL-RHPNVVLFMAASTKSPNMCIVME--------FMSL 865
Query: 530 SRQRDIQNNKFC-SITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIA 588
D+ N+ I +++ Q ++GM +LH+ IVH+ L N+++ VK++
Sbjct: 866 GSLYDLLGNELIPEIPYALKIKMAYQASKGMHFLHSSGIVHRDLKSLNLLLDSKWNVKVS 925
Query: 589 GFGLSHLRS---LHETPD----YTRWTSHEMLRQTRYNP--KADVWSFGVLMWEVLTLGA 639
FGL+ ++S +T D W + E+L + ADV+SFG+++WE+LT
Sbjct: 926 DFGLTKVKSELDKKKTNDNIIGTIHWIAPEILNDSTEVDYILADVYSFGIILWELLT-RE 984
Query: 640 TPYSHSGNKDVGSRILR-GMRP--SQPSYVGD--ELFQVCLQCWQVDPDERPTFSSLVIE 694
PY + ++R GMRP S + E + QCW D RPTF ++
Sbjct: 985 QPYKGMTPAAIAVSVIRDGMRPPISDEAVTAHSIEYIDLIKQCWHSDTIIRPTFLEIMTR 1044
Query: 695 LT 696
L+
Sbjct: 1045 LS 1046
>UniRef50_P42687 Cluster: Tyrosine-protein kinase SPK-1; n=1;
Girardia tigrina|Rep: Tyrosine-protein kinase SPK-1 -
Dugesia tigrina (Planarian)
Length = 497
Score = 114 bits (275), Expect = 7e-24
Identities = 69/251 (27%), Positives = 138/251 (54%), Gaps = 25/251 (9%)
Query: 477 KTEKKQMLQELDLLIKTSEHENVISLIGICET--NTTLLVVLEDIKK-TLKEMLLLSRQR 533
K E+++ + E ++ K H ++ L+G+C + +L+++E +K +LKE L
Sbjct: 254 KAEREKFVLEAKIMHKL-RHRKIVELLGVCTEPQDMPMLIIVEYMKNGSLKEYL------ 306
Query: 534 DIQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLS 593
+ K ++ N+++ + +++ GM YL + K+VH+ L N++++ + T K+A FGL+
Sbjct: 307 KTPDGKKTNL--NQMVHMMAEISEGMAYLESEKVVHRDLRADNILVANDLTRKVADFGLT 364
Query: 594 HLR--SLHETPDYT-----RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSG 646
L SL + T +WT+ E + + K+DVWS+G++M+E+LT ++PY
Sbjct: 365 ELTDGSLGDQEKKTLRFPYKWTAPEAAKSKVFTSKSDVWSYGIVMFEILTWASSPYPDIP 424
Query: 647 NKDVGSRILRGMR-PSQPSYV-----GDELFQVCLQCWQVDPDERPTFSSLVIELTPFSE 700
K+V ++ +G R P+ ++ DE++++ + CW +P++RPTF L ++
Sbjct: 425 AKEVIEKVSKGYRMPNPEKFITGVCCPDEIYKIMIWCWDANPEKRPTFLVLQEKMDLLIV 484
Query: 701 APGTRNLSFTH 711
T N ++H
Sbjct: 485 DTLTNNAYYSH 495
>UniRef50_UPI00015B5959 Cluster: PREDICTED: similar to insulin
receptor; n=1; Nasonia vitripennis|Rep: PREDICTED:
similar to insulin receptor - Nasonia vitripennis
Length = 1714
Score = 114 bits (274), Expect = 9e-24
Identities = 73/243 (30%), Positives = 121/243 (49%), Gaps = 13/243 (5%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLE-DIKKTLKEMLLLSRQRDIQN 537
E+ + L E ++ + H +V+ L+G+ LVV+E + LK L R +N
Sbjct: 1173 ERVEFLNEASVMKGFNTH-HVVRLLGVVSQGQPTLVVMELMVNGDLKTYLRSHRPDVCEN 1231
Query: 538 NKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRS 597
T N+++++ +++A GM YL +K VH+ L RN ++S++ TVKI FG++ R
Sbjct: 1232 FSRQPPTLNRIMRMALEIADGMAYLAAKKFVHRDLAARNCMVSDDLTVKIGDFGMT--RD 1289
Query: 598 LHETPDY---------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNK 648
++ET Y RW + E L+ + +DVWS+GV++WE++TL + PY N
Sbjct: 1290 VYETDYYRKGTKGLLPVRWMAPESLKDGVFTSFSDVWSYGVVLWEMVTLASQPYQGLSND 1349
Query: 649 DVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEAPGTRNLS 708
V ++ G +P D L+ + Q W RPTF + EL + +S
Sbjct: 1350 QVLRYVIDGGVMERPENCPDILYGMMRQTWCHKATRRPTFIDIERELMLEVDTTEFEKVS 1409
Query: 709 FTH 711
F H
Sbjct: 1410 FYH 1412
>UniRef50_Q9U531 Cluster: Focal adhesion kinase homolog DFak56;
n=15; Sophophora|Rep: Focal adhesion kinase homolog
DFak56 - Drosophila melanogaster (Fruit fly)
Length = 1200
Score = 114 bits (274), Expect = 9e-24
Identities = 71/228 (31%), Positives = 110/228 (48%), Gaps = 19/228 (8%)
Query: 471 ADRELEKTEKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLS 530
A+ + EKTE L E ++ K +H ++I LIGIC +V+ E+ L
Sbjct: 517 ANDDPEKTEN--FLAEAYIMQKF-DHPHIIRLIGICSVMPIWIVM---------ELAKLG 564
Query: 531 RQRDIQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGF 590
R ++ +L+ C Q++ + YL ++K VH+ + RN+++S VK+A F
Sbjct: 565 ELRAYLKTNSERLSHGTLLKYCYQLSTALSYLESKKFVHRDIAARNVLVSSPTCVKLADF 624
Query: 591 GLSHLRS----LHETPDYT---RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYS 643
GLS S H TP +W S E + R+ +DVW FGV +WE+L LG P+
Sbjct: 625 GLSRWVSDQSYYHSTPTVALPIKWMSPESINFRRFTTASDVWMFGVCIWEILMLGVKPFQ 684
Query: 644 HSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSL 691
N DV ++ G R P L+ + QCW +P +RP F +
Sbjct: 685 GVKNSDVILKLENGERLPLPPNCPPRLYSLMSQCWAYEPLKRPNFKRI 732
>UniRef50_O77132 Cluster: Non-receptor protein-tyrosine kinase CSK;
n=1; Hydra vulgaris|Rep: Non-receptor protein-tyrosine
kinase CSK - Hydra attenuata (Hydra) (Hydra vulgaris)
Length = 467
Score = 114 bits (274), Expect = 9e-24
Identities = 65/225 (28%), Positives = 115/225 (51%), Gaps = 11/225 (4%)
Query: 473 RELEKTEKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQ 532
R+ KT + +L E ++ T +H+N++ L+ I ++L++ E +K + L +R
Sbjct: 243 RDDSKTAQS-LLAEASVMT-TLQHKNLVVLVAISFQGDSILILTEYCEKGVLVEYLRTRG 300
Query: 533 RDIQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGL 592
R + IT + + V GM YL + I+H+ L RN+++S+ K++ FGL
Sbjct: 301 RAV-------ITLEEQKGFAIDVCNGMRYLEEKNIIHRDLAARNVLLSDELCAKVSDFGL 353
Query: 593 SH--LRSLHETPDYTRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDV 650
+ + L +WT+ E + ++ K+DVWSFG+L+WE+ + G PY ++
Sbjct: 354 AKDVEQELASGKFPVKWTAPEAIELKIFSTKSDVWSFGILLWEIFSFGRNPYPREPLDEL 413
Query: 651 GSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIEL 695
++I R P ++Q+ L+CW DP RP+F L EL
Sbjct: 414 LTKIKSNYRMECPEKCPPFVYQLMLKCWDADPSRRPSFKQLHNEL 458
>UniRef50_O02466 Cluster: Insulin-like peptide receptor precursor (EC
2.7.10.1) (ILP receptor) [Contains: Insulin-like peptide
receptor alpha chain; Insulin-like peptide receptor beta
chain]; n=4; Eukaryota|Rep: Insulin-like peptide receptor
precursor (EC 2.7.10.1) (ILP receptor) [Contains:
Insulin-like peptide receptor alpha chain; Insulin-like
peptide receptor beta chain] - Branchiostoma lanceolatum
(Common lancelet) (Amphioxus)
Length = 1363
Score = 114 bits (274), Expect = 9e-24
Identities = 80/261 (30%), Positives = 132/261 (50%), Gaps = 32/261 (12%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLE-----DIKKTLK-----EMLL 528
E+ + L E ++ KT +V+ L+G+ LVV+E D+K L+ E +
Sbjct: 1038 ERIEFLNEASVM-KTFNCHHVVKLMGVVSKGQPTLVVMELMALGDLKNYLRRHRPEEDVG 1096
Query: 529 LS---RQRDIQNNKFCSI------TENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMII 579
LS + +N+ F T ++Q+ +A GM YL +K VH+ L CRN ++
Sbjct: 1097 LSDSPASNEAKNSPFAENDNDLPPTFKDIIQMAGVIADGMSYLAAKKFVHRDLACRNCMV 1156
Query: 580 SENGTVKIAGFGLSHLRSLHETPDY---------TRWTSHEMLRQTRYNPKADVWSFGVL 630
+++ TVKI FG++ R ++ET Y RW S E L+ + ++DVWS+GV+
Sbjct: 1157 AQDRTVKIGDFGMT--RDIYETDYYRKGGKGLLPVRWMSPESLKVGVFTSQSDVWSYGVV 1214
Query: 631 MWEVLTLGATPYSHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSS 690
+WE+ TL + PY N++V ++ G +P ++L+ + CWQ RPTF
Sbjct: 1215 LWEMATLASQPYQGKSNEEVLKFVIDGGMLEKPEGCPNKLYDLMKLCWQYRQSMRPTFLE 1274
Query: 691 LVIELTPFSEAPGTRNLSFTH 711
+V L+P +A +SF H
Sbjct: 1275 IVEILSPELQA-HFNEVSFYH 1294
>UniRef50_UPI0000E47549 Cluster: PREDICTED: similar to Cek8; n=2;
Strongylocentrotus purpuratus|Rep: PREDICTED: similar to
Cek8 - Strongylocentrotus purpuratus
Length = 775
Score = 113 bits (273), Expect = 1e-23
Identities = 67/207 (32%), Positives = 110/207 (53%), Gaps = 14/207 (6%)
Query: 495 EHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNKFCSITENKVLQICVQ 554
+H NVI L+G+ ++V E ++ + L R+ D +F T ++L +
Sbjct: 474 DHPNVIKLLGVVTKTRPAMIVTEFMENGSLDKYL--REND---GRF---TVTQLLGMMRG 525
Query: 555 VARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSL---HETPDYT---RWT 608
V GM +L VH+ L RN++++E+ K+A FGLS + L +ET RWT
Sbjct: 526 VGFGMRFLSEMNFVHRDLAARNILVNEHLVCKVADFGLSRRKELDGAYETRGGKIPIRWT 585
Query: 609 SHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRILRGMRPSQPSYVGD 668
+ E + ++ +DVWS GV+MWE+++ G PY + N+DV + +G R P +
Sbjct: 586 APEAIGYKKFTSASDVWSLGVVMWEIMSYGERPYWNWPNQDVIKAVEKGYRLPPPMECPE 645
Query: 669 ELFQVCLQCWQVDPDERPTFSSLVIEL 695
+ Q+ L CWQ D + RPTF+++V L
Sbjct: 646 AIHQLMLDCWQRDRNHRPTFTTIVSTL 672
>UniRef50_Q9M085 Cluster: Protein kinase-like protein; n=22;
Magnoliophyta|Rep: Protein kinase-like protein -
Arabidopsis thaliana (Mouse-ear cress)
Length = 412
Score = 113 bits (273), Expect = 1e-23
Identities = 72/229 (31%), Positives = 118/229 (51%), Gaps = 16/229 (6%)
Query: 471 ADRELEKTE--KKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLL 528
+D EK + ++Q QE+ +L +H N++ IG C +V E K L
Sbjct: 163 SDSNPEKAQALEQQFQQEVSMLAFL-KHPNIVRFIGACIKPMVWCIVTEYAKGGSVRQFL 221
Query: 529 LSRQRDIQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIA 588
RQ K V+Q + VARGM Y+H R +H+ L N++IS + ++KIA
Sbjct: 222 TKRQNRAVPLKLA------VMQ-ALDVARGMAYVHERNFIHRDLKSDNLLISADRSIKIA 274
Query: 589 GFGLSHLRSLHE--TPD--YTRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSH 644
FG++ + E TP+ RW + EM++ Y K DV+SFG+++WE++T G P+ +
Sbjct: 275 DFGVARIEVQTEGMTPETGTYRWMAPEMIQHRPYTQKVDVYSFGIVLWELIT-GLLPFQN 333
Query: 645 SGNKDVGSRIL-RGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLV 692
++ RG+RP+ P+ L ++ +CW DP+ RP F+ +V
Sbjct: 334 MTAVQAAFAVVNRGVRPTVPADCLPVLGEIMTRCWDADPEVRPCFAEIV 382
>UniRef50_Q9NH62 Cluster: Tyrosine kinase 5; n=2; Schistosoma
mansoni|Rep: Tyrosine kinase 5 - Schistosoma mansoni
(Blood fluke)
Length = 647
Score = 113 bits (273), Expect = 1e-23
Identities = 65/220 (29%), Positives = 113/220 (51%), Gaps = 17/220 (7%)
Query: 480 KKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNK 539
K+ L+E ++ + ++H ++ L +C T + +V E + LL RD
Sbjct: 341 KEDFLKEARIM-RAAQHPKLVRLYAVC-TEDPIYIVTE----LMCNGSLLQYLRDGPGK- 393
Query: 540 FCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSLH 599
++ N+++ + Q+A GM YL +H+ L RN+++ EN VK+A FGL+ + H
Sbjct: 394 --NLLINQLVDMMAQIANGMAYLEKEHYIHRDLAARNILVGENNCVKVADFGLARMVEDH 451
Query: 600 --------ETPDYTRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVG 651
T +WT+ E R+ K+DVWSFG++++E++TLG PY N +
Sbjct: 452 YCTYMAQKSTKFPIKWTAPEAALMGRFTIKSDVWSFGIVIYELITLGQVPYPSMNNTETL 511
Query: 652 SRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSL 691
++ G R +P ++ + L+ W P++RPTFSSL
Sbjct: 512 HQVSTGYRMPRPVNCPQPIYDMLLRIWDSCPEKRPTFSSL 551
>UniRef50_Q9BL77 Cluster: C-terminal src kinase protein 1; n=2;
Caenorhabditis|Rep: C-terminal src kinase protein 1 -
Caenorhabditis elegans
Length = 539
Score = 113 bits (273), Expect = 1e-23
Identities = 61/219 (27%), Positives = 117/219 (53%), Gaps = 13/219 (5%)
Query: 483 MLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNKFCS 542
+L E ++ S H N+++L+G+ + + ++ E + LL SR R +
Sbjct: 323 LLDEAKFMVGLS-HPNLVTLVGVVLDDVNVYMITEYMANGNLIDLLRSRGRH-------A 374
Query: 543 ITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSL--HE 600
+ +++ + + +GM YL +++IVH+ L RN+++ ++ K++ FGL+ + H+
Sbjct: 375 LERRQLMMFAMDICQGMCYLESKQIVHRDLAARNVLLDDDLVAKVSDFGLAKKANSQSHD 434
Query: 601 TPDYT---RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRILRG 657
+ +WT+ E LR +++ K+DVWSFG+L+WE+ + G PY +DV I +G
Sbjct: 435 SASGKFPIKWTAPEALRHSQFTTKSDVWSFGILLWEIFSFGRVPYPRIPIQDVVRYIEKG 494
Query: 658 MRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELT 696
R P E+F+V + W + +RP+F ++ LT
Sbjct: 495 YRMEAPEGCPPEIFKVMNETWALSAQDRPSFGQVLQRLT 533
>UniRef50_Q6SAJ2 Cluster: Epidermal growth factor receptor; n=11;
Diptera|Rep: Epidermal growth factor receptor -
Drosophila melanogaster (Fruit fly)
Length = 1325
Score = 113 bits (273), Expect = 1e-23
Identities = 61/200 (30%), Positives = 98/200 (49%), Gaps = 9/200 (4%)
Query: 512 LLVVLEDIKKTLKEMLLLSRQRDIQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKK 571
L V + + +++ L D N I +L Q+A+GM YL +++VH+
Sbjct: 903 LAVCMSSQMMLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEEKRLVHRD 962
Query: 572 LCCRNMIISENGTVKIAGFGLSHLRSLHETPDYT--------RWTSHEMLRQTRYNPKAD 623
L RN+++ VKI FGL+ L S ++ +Y +W + E +R + K+D
Sbjct: 963 LAARNVLVQTPSLVKITDFGLAKLLS-SDSNEYKAAGGKMPIKWLALECIRNRVFTSKSD 1021
Query: 624 VWSFGVLMWEVLTLGATPYSHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPD 683
VW+FGV +WE+LT G P+ + KD+ I G++ QP +++ L CW +D
Sbjct: 1022 VWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAA 1081
Query: 684 ERPTFSSLVIELTPFSEAPG 703
RPTF L F+ PG
Sbjct: 1082 MRPTFKQLTTVFAEFARDPG 1101
>UniRef50_Q21041 Cluster: Putative uncharacterized protein ver-4; n=1;
Caenorhabditis elegans|Rep: Putative uncharacterized
protein ver-4 - Caenorhabditis elegans
Length = 1199
Score = 113 bits (273), Expect = 1e-23
Identities = 55/164 (33%), Positives = 91/164 (55%), Gaps = 9/164 (5%)
Query: 538 NKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLS---- 593
++F S+ + +L I +Q+A GM++L VH+ L CRN++IS+ ++IA FGL+
Sbjct: 992 DEFNSLCTSDLLSIGLQIANGMDWLANIPCVHRDLACRNVLISKTKIIRIADFGLAKKHT 1051
Query: 594 -----HLRSLHETPDYTRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNK 648
+R +TP RW E + + K+DVWS+G+ ++E+ TLG TPY N
Sbjct: 1052 DKAYYRVRESLDTPLPVRWMPLESITDLTFTQKSDVWSYGICLYEIFTLGGTPYPDCPNF 1111
Query: 649 DVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLV 692
+ I G +PS +++++ CWQ PD+RPTF+ +
Sbjct: 1112 SLVEYIKTGNINKRPSNCHKDVYKIMKMCWQASPDDRPTFAECI 1155
>UniRef50_Q9H3Y6 Cluster: Tyrosine-protein kinase Srms; n=17;
Amniota|Rep: Tyrosine-protein kinase Srms - Homo sapiens
(Human)
Length = 488
Score = 113 bits (273), Expect = 1e-23
Identities = 66/208 (31%), Positives = 110/208 (52%), Gaps = 15/208 (7%)
Query: 491 IKTSEHENVISLIGICETNTTLLVVLEDIKK-TLKEMLLLSRQRDIQNNKFCSITENKVL 549
+K HE +I L +C + +V E ++K L+ L R ++ +L
Sbjct: 277 LKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGR--------ALRLPPLL 328
Query: 550 QICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHL-RSLHETPDYT--- 605
QVA GM YL +++VH+ L RN+++ + K+A FGL+ L + +P +
Sbjct: 329 GFACQVAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKI 388
Query: 606 --RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRILRGMRPSQP 663
+WT+ E ++ K+DVWSFGVL+ EV T G PY N + +I+RG R +P
Sbjct: 389 PVKWTAPEAANYRVFSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRP 448
Query: 664 SYVGDELFQVCLQCWQVDPDERPTFSSL 691
+ E++ + L+CW+ P+ERP+F++L
Sbjct: 449 AACPAEVYVLMLECWRSSPEERPSFATL 476
>UniRef50_P29323 Cluster: Ephrin type-B receptor 2 precursor; n=311;
Eumetazoa|Rep: Ephrin type-B receptor 2 precursor - Homo
sapiens (Human)
Length = 1055
Score = 113 bits (273), Expect = 1e-23
Identities = 71/236 (30%), Positives = 118/236 (50%), Gaps = 19/236 (8%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNN 538
+++ L E ++ + +H NVI L G+ +T ++++ E ++ + L RQ D Q
Sbjct: 663 QRRDFLSEASIMGQF-DHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFL--RQNDGQ-- 717
Query: 539 KFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSH-LRS 597
T +++ + +A GM+YL VH+ L RN++++ N K++ FGLS L
Sbjct: 718 ----FTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLED 773
Query: 598 LHETPDYT---------RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNK 648
P YT RWT+ E ++ ++ +DVWS+G++MWEV++ G PY N+
Sbjct: 774 DTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQ 833
Query: 649 DVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEAPGT 704
DV + I + R P L Q+ L CWQ D + RP F +V L P +
Sbjct: 834 DVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNS 889
>UniRef50_UPI00004D7E5F Cluster: Proto-oncogene tyrosine-protein
kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor
tyrosine kinase MerTK).; n=1; Xenopus tropicalis|Rep:
Proto-oncogene tyrosine-protein kinase MER precursor (EC
2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK). -
Xenopus tropicalis
Length = 763
Score = 113 bits (272), Expect = 2e-23
Identities = 73/214 (34%), Positives = 108/214 (50%), Gaps = 17/214 (7%)
Query: 491 IKTSEHENVISLIGIC-ETNTTLL----VVLEDIKK-TLKEMLLLSRQRDIQNNKFCSIT 544
+K H NVI L+G+C E + V+L +K L LL SR + +
Sbjct: 525 MKDFNHPNVIRLLGVCLEVGPRRIPKPMVILPFMKYGDLHSFLLSSRIGSGPQH----VP 580
Query: 545 ENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLS-------HLRS 597
+++ + +A GMEYL +R +H+ L RN ++ ++ TV +A FGLS + R
Sbjct: 581 LRTLVKFMIDIATGMEYLSSRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQ 640
Query: 598 LHETPDYTRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRILRG 657
+W + E L Y K+DVW+FGV MWE+ T G TPY N ++ +L G
Sbjct: 641 GRIAKMPVKWIAVESLADRIYTVKSDVWAFGVTMWEISTRGMTPYPGVQNHEIYDYLLVG 700
Query: 658 MRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSL 691
R QP D+L+ V QCW DP RP+F++L
Sbjct: 701 HRLKQPPECLDDLYTVMYQCWLSDPTCRPSFTAL 734
>UniRef50_Q70W05 Cluster: Src protein; n=1; Ciona intestinalis|Rep:
Src protein - Ciona intestinalis (Transparent sea
squirt)
Length = 355
Score = 113 bits (272), Expect = 2e-23
Identities = 53/168 (31%), Positives = 95/168 (56%), Gaps = 7/168 (4%)
Query: 535 IQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSH 594
I++ K + E+ ++++ +QVA GM YL +H+ L RN+++ +N KIA FGL+
Sbjct: 178 IKSEKGKDLNEDTLIEMAIQVATGMVYLEVNDYIHRDLAARNILVGKNNICKIADFGLAR 237
Query: 595 LRSLHETPDYT-------RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGN 647
+ ++ RWT+ E ++ K+DVWSFG+L+ E++ G PY+
Sbjct: 238 VTQGNDIYQAKVGAEFPIRWTAPEAATMQQFTIKSDVWSFGILLTEIIGNGRVPYAGFQT 297
Query: 648 KDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIEL 695
+V ++ RG R + ++L+ + + CW DP++RP+F SLV++L
Sbjct: 298 FEVLEQVERGYRMEKLEKCSEQLYDIMMACWHKDPNQRPSFESLVMQL 345
>UniRef50_O76809 Cluster: Receptor tyrosine kinase HTK30; n=1; Hydra
vulgaris|Rep: Receptor tyrosine kinase HTK30 - Hydra
attenuata (Hydra) (Hydra vulgaris)
Length = 1081
Score = 113 bits (272), Expect = 2e-23
Identities = 63/183 (34%), Positives = 97/183 (53%), Gaps = 15/183 (8%)
Query: 515 VLEDIKKTLKEMLLLSRQRDIQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCC 574
VLE I+KT E+ L+ + S+T N +L QVA GMEYL K VH+ L
Sbjct: 908 VLEAIRKTSNEVSLM---------EMGSLTPNDLLCFAWQVASGMEYLACMKFVHRDLAA 958
Query: 575 RNMIISENGTVKIAGFGLSHLRSLHETPDY------TRWTSHEMLRQTRYNPKADVWSFG 628
RN+++ N +KI+ FGL+ L +W S E + + +DVWSFG
Sbjct: 959 RNILVGANKNIKISDFGLTRKVDLDVYMGAKSRRLPVKWMSIEAIFDRTFTSSSDVWSFG 1018
Query: 629 VLMWEVLTLGATPYSHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTF 688
V+++E++TLG TPY N ++ + + G R +P ++++ + LQCW +P RP F
Sbjct: 1019 VVLFEIITLGGTPYPTITNNELLALLKSGYRMDRPGNCSEQMYDIMLQCWNENPLGRPNF 1078
Query: 689 SSL 691
+ L
Sbjct: 1079 TEL 1081
>UniRef50_O76385 Cluster: Putative uncharacterized protein; n=3;
Caenorhabditis|Rep: Putative uncharacterized protein -
Caenorhabditis elegans
Length = 903
Score = 113 bits (272), Expect = 2e-23
Identities = 69/244 (28%), Positives = 126/244 (51%), Gaps = 24/244 (9%)
Query: 476 EKTEKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLE-----DIKKTLKEMLLLS 530
++ K + L+E+ L+ HE +++++ + L +V+E D+ K L+E
Sbjct: 598 DEMSKHEFLREIALMKTLGYHERLVNMLACVTESEPLCLVVEYCDNGDLLKFLRERCKYM 657
Query: 531 RQRDI---------QNNKFCS---ITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMI 578
+ D +N + + +T ++LQ VQ++ G+EYL + VH+ + RN++
Sbjct: 658 MKLDDLGINYHDPPENENYDTNMIVTLKQLLQFAVQISYGLEYLSQKGFVHRDVAARNVL 717
Query: 579 ISENGTVKIAGFGLSHL----RSLHETPDYT---RWTSHEMLRQTRYNPKADVWSFGVLM 631
+ E KI FGL +S +++ +W S E +R ++ K+D+WSFG+L+
Sbjct: 718 VHEGTACKIGDFGLCRYIYADQSQYKSKGGKLPLKWMSPEAIRHYEFSIKSDIWSFGILL 777
Query: 632 WEVLTLGATPYSHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSL 691
+EV+TLG +PY +DV + G R +P + + V +QCW DPD+R FS +
Sbjct: 778 FEVITLGGSPYPGMPPEDVLPFLEGGGRIEKPDNCPENFYDVMMQCWNADPDDRIEFSDV 837
Query: 692 VIEL 695
++L
Sbjct: 838 RMQL 841
>UniRef50_A7SFD8 Cluster: Predicted protein; n=2; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 229
Score = 113 bits (272), Expect = 2e-23
Identities = 63/214 (29%), Positives = 114/214 (53%), Gaps = 12/214 (5%)
Query: 476 EKTEKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIK-KTLKEMLLLSRQRD 534
+ ++ + LQE ++ + H NV+ + G+ + +++VLE + L+ LL R +
Sbjct: 13 DSEDRVKFLQEAAIM-RQFTHRNVVYMYGVVTNSNPIMIVLEHMSLGNLRNYLLNLRLKY 71
Query: 535 IQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSH 594
+ C T +++L + +A GM+YLH+ VH+ L RN+++ + KI FG+S
Sbjct: 72 GKEVVLCLDTRSQLLGMIRDIAAGMQYLHSLGFVHRDLAARNILLDSDMICKIGDFGMS- 130
Query: 595 LRSLHETPDYT--------RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSG 646
R L YT +WT+ E + RY+ +DVWS+GVL++E+ +LG PY++
Sbjct: 131 -RDLMICDYYTSRGGRIPVKWTAPEAINYGRYSSASDVWSYGVLLFEIWSLGDKPYANLD 189
Query: 647 NKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQV 680
N +V + RG R P + ++++ + CW V
Sbjct: 190 NNEVVEAVSRGYRLPPPDHCPTMIYRLMVDCWYV 223
>UniRef50_P03949 Cluster: Tyrosine-protein kinase abl-1; n=5;
Caenorhabditis|Rep: Tyrosine-protein kinase abl-1 -
Caenorhabditis elegans
Length = 1224
Score = 113 bits (272), Expect = 2e-23
Identities = 64/212 (30%), Positives = 103/212 (48%), Gaps = 13/212 (6%)
Query: 490 LIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNKFCSITENKVL 549
++K H+N++ L+G+C ++ E + LL R + I ++
Sbjct: 358 IMKDLHHKNLVRLLGVCTHEAPFYIITE----FMCNGNLLEYLRRTDKSLLPPII---LV 410
Query: 550 QICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLR-----SLHETPDY 604
Q+ Q+A GM YL R +H+ L RN ++SE+ VKIA FGL+ + H +
Sbjct: 411 QMASQIASGMSYLEARHFIHRDLAARNCLVSEHNIVKIADFGLARFMKEDTYTAHAGAKF 470
Query: 605 T-RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRILRGMRPSQP 663
+WT+ E L ++ K+DVW+FGVL+WE+ T G PY +V + G R P
Sbjct: 471 PIKWTAPEGLAFNTFSSKSDVWAFGVLLWEIATYGMAPYPGVELSNVYGLLENGFRMDGP 530
Query: 664 SYVGDELFQVCLQCWQVDPDERPTFSSLVIEL 695
++++ LQCW P +RP F + L
Sbjct: 531 QGCPPSVYRLMLQCWNWSPSDRPRFRDIHFNL 562
>UniRef50_UPI00015B54DC Cluster: PREDICTED: similar to vascular
endothelial growth factor receptor 2; n=1; Nasonia
vitripennis|Rep: PREDICTED: similar to vascular
endothelial growth factor receptor 2 - Nasonia
vitripennis
Length = 1005
Score = 113 bits (271), Expect = 2e-23
Identities = 55/169 (32%), Positives = 93/169 (55%), Gaps = 6/169 (3%)
Query: 533 RDIQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGL 592
R+I++++ S+ +L QVARGMEYL + ++H L RN++++ N VKI FGL
Sbjct: 792 RNIESSRKESLCTQDLLSWAFQVARGMEYLSQKNVLHGDLAARNILLTHNNVVKICDFGL 851
Query: 593 SHLRSLHETPDYTR------WTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSG 646
+ + +R W + E +R ++ +DVWSFG+++WE TL PY
Sbjct: 852 AKVMEDDSYMKRSRGLLPIKWMAIESIRDRVFSVHSDVWSFGIVLWEFFTLAQVPYCDIL 911
Query: 647 NKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIEL 695
+ ++L+G R +P Y E++ + + CW +P RPTF+ LV ++
Sbjct: 912 PEVQLQKLLKGHRLEKPKYANGEIYSIMVPCWNEEPTLRPTFTMLVEQI 960
>UniRef50_Q4RXA0 Cluster: Chromosome 11 SCAF14979, whole genome
shotgun sequence; n=5; Euteleostomi|Rep: Chromosome 11
SCAF14979, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 1042
Score = 113 bits (271), Expect = 2e-23
Identities = 69/231 (29%), Positives = 106/231 (45%), Gaps = 21/231 (9%)
Query: 485 QELDLLIKTS-----EHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNK 539
Q LD L + S H N+I L G+ +++V E + + L R +I +
Sbjct: 724 QRLDFLSEASIMGQFSHPNIIHLEGVVTKFKHIMIVTEYMDNGALDTYLKGRDGEIPPYQ 783
Query: 540 FCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSLH 599
+ +A GM+YL VH+ L RN++++ N K++ FGLS +
Sbjct: 784 LVGMLRG--------IAAGMQYLSNMSYVHRDLAARNILVNSNLECKVSDFGLSRVLEDD 835
Query: 600 ETPDYT--------RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVG 651
+ YT RWT+ E + ++ +DVWSFG++MWEV+ G PY N +V
Sbjct: 836 DEGTYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSFGIVMWEVMAFGERPYWDMSNHEVM 895
Query: 652 SRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEAP 702
I R P ++Q+ LQCWQ D +RP FS +V L +P
Sbjct: 896 KAINEAFRLPAPMDCPSAIYQLMLQCWQHDRSKRPRFSDIVSFLDKLLRSP 946
>UniRef50_Q4RL31 Cluster: Chromosome undetermined SCAF15024, whole
genome shotgun sequence; n=8; Euteleostomi|Rep:
Chromosome undetermined SCAF15024, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 511
Score = 113 bits (271), Expect = 2e-23
Identities = 61/174 (35%), Positives = 91/174 (52%), Gaps = 7/174 (4%)
Query: 534 DIQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLS 593
D+ + C + ++ IC Q+A GM Y+ R +H+ L N+++SE KIA FGL+
Sbjct: 330 DVASGSRCGLLTERMC-ICGQIAEGMAYIERRNYIHRDLRAANVLVSECLLCKIADFGLA 388
Query: 594 HL-----RSLHETPDYT-RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGN 647
+ S E + +WT+ E + + K+D+WSFGVL++E++T G PY
Sbjct: 389 RVIEDDEYSAREGAKFPIKWTAPEAINYGSFTIKSDMWSFGVLLYEIITYGKIPYPGMTK 448
Query: 648 KDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEA 701
+V S I RG R QP EL+ + L CW+ PD RPTF + L F A
Sbjct: 449 GEVISSIQRGYRMPQPDSCPSELYHMMLDCWKDKPDARPTFEYMQSVLNDFYTA 502
>UniRef50_A2CG59 Cluster: Eph receptor B1; n=23; Euteleostomi|Rep:
Eph receptor B1 - Mus musculus (Mouse)
Length = 943
Score = 113 bits (271), Expect = 2e-23
Identities = 69/236 (29%), Positives = 119/236 (50%), Gaps = 19/236 (8%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNN 538
+++ L E ++ + +H N+I L G+ + ++++ E ++ + L RQ D Q
Sbjct: 620 QRRDFLSEASIMGQF-DHPNIIRLEGVVTKSRPVMIITEFMENGALDSFL--RQNDGQ-- 674
Query: 539 KFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLS-HLRS 597
T +++ + +A GM+YL VH+ L RN++++ N K++ FGLS +L+
Sbjct: 675 ----FTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQD 730
Query: 598 LHETPDYT---------RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNK 648
P YT RWT+ E + ++ +DVWS+G++MWEV++ G PY N+
Sbjct: 731 DTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQ 790
Query: 649 DVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEAPGT 704
DV + I + R P L Q+ L CWQ D + RP F+ +V L P +
Sbjct: 791 DVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTLDKMIRNPAS 846
>UniRef50_Q9V4E5 Cluster: CG1511-PC, isoform C; n=12; Diptera|Rep:
CG1511-PC, isoform C - Drosophila melanogaster (Fruit
fly)
Length = 1096
Score = 113 bits (271), Expect = 2e-23
Identities = 68/217 (31%), Positives = 112/217 (51%), Gaps = 19/217 (8%)
Query: 495 EHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNKFCSITENKVLQICVQ 554
+H NVI L G+ + ++++ E ++ + L + + KF ++ +++ +
Sbjct: 800 DHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLR-----VNDGKFQTL---QLIVMLRG 851
Query: 555 VARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSLHETPD-YT-------- 605
+A GM YL VH+ L RN++++ KIA FGLS R + D YT
Sbjct: 852 IASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLS--REIENASDAYTTRGGKIPV 909
Query: 606 RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRILRGMRPSQPSY 665
RWT+ E + ++ +DVWS+GV++WEV++ G PY + N+DV I +G R P
Sbjct: 910 RWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMD 969
Query: 666 VGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEAP 702
+ L+Q+ L CWQ RPTF+S+V L + P
Sbjct: 970 CPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQP 1006
>UniRef50_Q16XX9 Cluster: Tyrosine-protein kinase shark; n=2;
Culicidae|Rep: Tyrosine-protein kinase shark - Aedes
aegypti (Yellowfever mosquito)
Length = 939
Score = 113 bits (271), Expect = 2e-23
Identities = 73/226 (32%), Positives = 110/226 (48%), Gaps = 23/226 (10%)
Query: 477 KTEKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRD-I 535
K + L+E ++I+ H ++ LIGIC+ ++V +E++ L D I
Sbjct: 699 KRNRVDFLREASVMIRL-RHHCIVKLIGICKGPPLMMV---------EELVPLGSMLDYI 748
Query: 536 QNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHL 595
NK + +++ Q+A GM+YL VH+ L RN++++ KI+ FGLS
Sbjct: 749 IANKGTINPKLELVIWAAQIACGMQYLEQHHFVHRDLAARNILLASRNQAKISDFGLS-- 806
Query: 596 RSLHETPDYTR----------WTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHS 645
R++ DY R W + E ++ +DVWSFGV MWE+ +LGA PY
Sbjct: 807 RAIGAGDDYYRASQGGKWPIKWYAPESFNYGTFSHASDVWSFGVTMWEMYSLGAPPYQDM 866
Query: 646 GNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSL 691
DV I G R SQP + +F+V CW +P RPTF L
Sbjct: 867 KGVDVIKLIENGQRLSQPDLCPENVFEVMKNCWNYNPKSRPTFKFL 912
>UniRef50_P09619 Cluster: Beta-type platelet-derived growth factor
receptor precursor; n=25; Amniota|Rep: Beta-type
platelet-derived growth factor receptor precursor - Homo
sapiens (Human)
Length = 1106
Score = 113 bits (271), Expect = 2e-23
Identities = 58/152 (38%), Positives = 88/152 (57%), Gaps = 12/152 (7%)
Query: 554 QVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSLHETPDYT-------- 605
QVA GME+L ++ VH+ L RN++I E VKI FGL+ R + +Y
Sbjct: 809 QVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLA--RDIMRDSNYISKGSTFLP 866
Query: 606 -RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSH-SGNKDVGSRILRGMRPSQP 663
+W + E + + Y +DVWSFG+L+WE+ TLG TPY N+ + I RG R +QP
Sbjct: 867 LKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQP 926
Query: 664 SYVGDELFQVCLQCWQVDPDERPTFSSLVIEL 695
++ DE++++ +CW+ + RP FS LV+ L
Sbjct: 927 AHASDEIYEIMQKCWEEKFEIRPPFSQLVLLL 958
>UniRef50_P29317 Cluster: Ephrin type-A receptor 2 precursor; n=32;
Euteleostomi|Rep: Ephrin type-A receptor 2 precursor -
Homo sapiens (Human)
Length = 976
Score = 113 bits (271), Expect = 2e-23
Identities = 72/237 (30%), Positives = 122/237 (51%), Gaps = 23/237 (9%)
Query: 478 TEKKQM--LQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDI 535
TEK+++ L E ++ + S H N+I L G+ ++++ E ++ + L R++D
Sbjct: 653 TEKQRVDFLGEAGIMGQFSHH-NIIRLEGVISKYKPMMIITEYMENGALDKFL--REKD- 708
Query: 536 QNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHL 595
+F + +++ + +A GM+YL VH+ L RN++++ N K++ FGLS
Sbjct: 709 --GEFSVL---QLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLS-- 761
Query: 596 RSLHETPDYT----------RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHS 645
R L + P+ T RWT+ E + ++ +DVWSFG++MWEV+T G PY
Sbjct: 762 RVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWEL 821
Query: 646 GNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEAP 702
N +V I G R P ++Q+ +QCWQ + RP F+ +V L AP
Sbjct: 822 SNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIRAP 878
>UniRef50_UPI000069DB6A Cluster: Ephrin type-A receptor 6 precursor
(EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2)
(EPH homology kinase 2).; n=2; Xenopus tropicalis|Rep:
Ephrin type-A receptor 6 precursor (EC 2.7.10.1)
(Tyrosine-protein kinase receptor EHK-2) (EPH homology
kinase 2). - Xenopus tropicalis
Length = 952
Score = 112 bits (269), Expect = 4e-23
Identities = 71/224 (31%), Positives = 118/224 (52%), Gaps = 21/224 (9%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNN 538
++K L+E ++ + +H N+I L G+ + +++V+E ++ + L R+ D Q
Sbjct: 630 QRKDFLREASIMGQF-DHPNIIRLEGVVTKSRPVMIVVEYMENGSLDSFL--RKHDGQ-- 684
Query: 539 KFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSL 598
T +++ + +A GM+YL VH+ L RN++++ N K++ FGLS R L
Sbjct: 685 ----FTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILVNSNLVCKVSDFGLS--RVL 738
Query: 599 HETPD--YT--------RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNK 648
+ PD YT RWT+ E + +++ +D WS+G++MWEV++ G PY N+
Sbjct: 739 EDDPDAAYTTTGGKIPIRWTAPEAIAFRKFSSASDAWSYGIVMWEVMSYGERPYWEMSNQ 798
Query: 649 DVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLV 692
DV I G R P L Q+ L CWQ D + RP FS +V
Sbjct: 799 DVILSIEEGYRLPAPMGCPVSLHQLMLHCWQKDRNIRPKFSDIV 842
>UniRef50_Q4SMF1 Cluster: Chromosome 8 SCAF14552, whole genome
shotgun sequence; n=8; Clupeocephala|Rep: Chromosome 8
SCAF14552, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 714
Score = 111 bits (268), Expect = 5e-23
Identities = 73/237 (30%), Positives = 113/237 (47%), Gaps = 20/237 (8%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNN 538
EK L E +L + +H NV+ L G+ +V E ++ + L +
Sbjct: 395 EKGMFLSEAGVLGQF-DHPNVLKLEGVITRTPPERIVTEFMENGPLDSFLRENE-----G 448
Query: 539 KFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHL-RS 597
+F + +++ + + GM YL R VH+ L RN++++ N K++ FGLS L R
Sbjct: 449 QFSVL---QLVGMLRGIGAGMRYLAERNFVHRDLAARNVLVNSNLVCKVSDFGLSRLMRG 505
Query: 598 L-HETPDYT---------RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGN 647
L H P YT RWT+ E + +++ +DVWSFGVLMWEV++ G PY N
Sbjct: 506 LDHNIPTYTASLGSKIPVRWTAPEAFQHRKFSSASDVWSFGVLMWEVMSYGERPYWDMSN 565
Query: 648 KDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEAPGT 704
++V + R P L + LQCWQ D +RP F +L+ L P +
Sbjct: 566 QEVMKAVADQYRLPAPHSCPPALHSLMLQCWQADRGDRPAFETLLSSLDRLIRHPAS 622
>UniRef50_Q4SFJ9 Cluster: Chromosome 7 SCAF14601, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 7 SCAF14601, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 761
Score = 111 bits (268), Expect = 5e-23
Identities = 70/236 (29%), Positives = 116/236 (49%), Gaps = 19/236 (8%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNN 538
+++ L E ++ + +H N+I L G+ + ++++ E ++ + L R D Q
Sbjct: 451 QRRDFLSEASIMGQF-QHPNIIHLEGVITASCPVMILTEFMENGALDSFL--RLNDSQ-- 505
Query: 539 KFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSH-LRS 597
T +++ + +A GM+YL VH+ L RN++I+ N K++ FGLS L+
Sbjct: 506 ----FTPIQLVGMLRGIASGMKYLSEMSYVHRDLAARNILINSNLVCKVSDFGLSRFLQE 561
Query: 598 LHETPDYT---------RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNK 648
P YT RWT+ E + ++ +DVWS+G++MWEV++ G PY N+
Sbjct: 562 NSSDPTYTSSLGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQ 621
Query: 649 DVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEAPGT 704
DV + I + R P L Q+ L CWQ D RP F+ LV L P +
Sbjct: 622 DVINAIEQDYRLPPPPDCPTHLHQLMLDCWQKDRSARPRFADLVSALDKLIRNPAS 677
>UniRef50_A7R2R7 Cluster: Chromosome chr4 scaffold_443, whole genome
shotgun sequence; n=7; Magnoliophyta|Rep: Chromosome
chr4 scaffold_443, whole genome shotgun sequence - Vitis
vinifera (Grape)
Length = 226
Score = 111 bits (268), Expect = 5e-23
Identities = 64/201 (31%), Positives = 108/201 (53%), Gaps = 16/201 (7%)
Query: 498 NVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNKFCSITENKVLQICVQVAR 557
NV+ IG C L ++ E + + L +QR + +L++ + VA+
Sbjct: 1 NVVQFIGACTRPPNLCIITEFMSRG-SVYDFLHKQRG-------AFKLPSLLKVAIDVAK 52
Query: 558 GMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRS-----LHETPDYTRWTSHEM 612
GM YLH I+H+ L N+++ EN VK+A FG++ +++ ET Y RW + E+
Sbjct: 53 GMNYLHENNIIHRDLKTANLLMDENDVVKVADFGVARVQTQSGVMTAETGTY-RWMAPEV 111
Query: 613 LRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRIL-RGMRPSQPSYVGDELF 671
+ YN KADV+SFG+++WE+LT G PYS ++ +G+RP+ P + ++
Sbjct: 112 IEHRPYNHKADVFSFGIVLWELLT-GELPYSFLTPLQAAVGVVQKGLRPTVPKHTHPKIA 170
Query: 672 QVCLQCWQVDPDERPTFSSLV 692
+ +CW DP RP FS+++
Sbjct: 171 GLLERCWWQDPTLRPDFSTIL 191
>UniRef50_Q17IF1 Cluster: Receptor protein tyrosine kinase; n=1;
Aedes aegypti|Rep: Receptor protein tyrosine kinase -
Aedes aegypti (Yellowfever mosquito)
Length = 636
Score = 111 bits (268), Expect = 5e-23
Identities = 60/173 (34%), Positives = 98/173 (56%), Gaps = 13/173 (7%)
Query: 528 LLSRQRDIQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKI 587
L S +R+ Q+ ++ IT ++L+ Q+A GME+L K+VH+ L RN+++ + VKI
Sbjct: 425 LCSEKRN-QSEEYI-ITSRQLLEFAKQIAIGMEFLARNKVVHRDLAARNVLVCYDKAVKI 482
Query: 588 AGFGLSHLRSLHETPDYTR---------WTSHEMLRQTRYNPKADVWSFGVLMWEVLTLG 638
+ FGLS R +++ Y + W + E L Y ++DVWS+G+L++E+ TLG
Sbjct: 483 SDFGLS--RDIYQQNLYRKTGTGKLPIKWLALESLTHQVYTSQSDVWSYGILLYEICTLG 540
Query: 639 ATPYSHSGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSL 691
PY D+ + RG R +P EL+++ L CW P +RPTF+S+
Sbjct: 541 GNPYPLLSTCDLIMELKRGYRMEKPDSCSKELYELMLSCWSALPIDRPTFTSI 593
>UniRef50_O77440 Cluster: Protein-tyrosine kinase HTK98; n=1; Hydra
vulgaris|Rep: Protein-tyrosine kinase HTK98 - Hydra
attenuata (Hydra) (Hydra vulgaris)
Length = 624
Score = 111 bits (268), Expect = 5e-23
Identities = 62/230 (26%), Positives = 121/230 (52%), Gaps = 23/230 (10%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNN 538
+K ++++E +++ K +H N++ LIG+ ++ +LV+ + L + L +R ++ +
Sbjct: 399 QKSEIVKEAEIMSKL-DHPNIVRLIGVTQSPGFMLVMELAPQGPLHKFLKKNRNMNVLD- 456
Query: 539 KFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSL 598
+L + +QV GM YL ++ VH+ L RN+++ VKI+ FG+S R++
Sbjct: 457 ---------ILVLMLQVDEGMNYLESQHFVHRDLAARNVLVVSENFVKISDFGMS--RAM 505
Query: 599 HETPDYTR----------WTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNK 648
+Y R W + E + +++ K DVWS+G+ MWE ++ G PY
Sbjct: 506 GVGNEYYRAERAGKWPLKWYAPECIYYHKFSSKGDVWSYGITMWEAVSYGGKPYQGMRGP 565
Query: 649 DVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPF 698
+ ++ G R +P D ++ + L+CW+ +PD+RP+F + I L +
Sbjct: 566 VIVEKLESGYRLPKPDNCSDAVYTLMLKCWETNPDDRPSFMEIGIILAQY 615
>UniRef50_UPI00015B55E4 Cluster: PREDICTED: similar to receptor-like
tyrosine kinase; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to receptor-like tyrosine kinase -
Nasonia vitripennis
Length = 503
Score = 111 bits (267), Expect = 6e-23
Identities = 57/164 (34%), Positives = 91/164 (55%), Gaps = 11/164 (6%)
Query: 544 TENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSLHETPD 603
++ +V+++ +Q A+G++YLH +++VH+ L RN ++ + V+I L+ R L
Sbjct: 334 SQPQVVEMALQAAKGVQYLHRKRLVHRDLAARNCVVDDELRVQITDNALA--RDLFPQDY 391
Query: 604 YT---------RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRI 654
Y +W + E L ++ +DVW+FGVL+WE+ TL PY ++ S +
Sbjct: 392 YCLGDNENRPIKWLAIESLLSKSFSTASDVWAFGVLLWELTTLAQQPYVEVDPFEMASYL 451
Query: 655 LRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPF 698
G R +QP DELF V CW + PDERPTFS L++ L F
Sbjct: 452 RDGYRLAQPVNCPDELFAVMAYCWAMSPDERPTFSQLIVCLQEF 495
>UniRef50_Q7Q0F6 Cluster: Tyrosine-protein kinase receptor; n=2;
Cellia|Rep: Tyrosine-protein kinase receptor - Anopheles
gambiae str. PEST
Length = 1318
Score = 111 bits (267), Expect = 6e-23
Identities = 67/231 (29%), Positives = 118/231 (51%), Gaps = 15/231 (6%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNN 538
E+ L E ++ + H +V+ L G+ LV++E + + L + D +N
Sbjct: 1036 ERDSFLIEATIMKEFHTH-HVVRLYGVVSVGQPTLVIMELMANGDLKSYLRRHRPDYENG 1094
Query: 539 KFCSI---TENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHL 595
+ S T ++ Q+ +++A GM YL +K VH+ L RN +++E+ TVKI FG++
Sbjct: 1095 EESSPQPPTLKQIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVAEDLTVKIGDFGMT-- 1152
Query: 596 RSLHETPDY---------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSG 646
R ++ET Y RW + E L+ ++ +DV+S+GV++WE+ TL + PY
Sbjct: 1153 RDIYETDYYRKGTKGFLPVRWMAPESLKDGMFSSSSDVFSYGVVLWEMATLASQPYQGLT 1212
Query: 647 NKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTP 697
N V ++ G +P D+L+++ CWQ RP+F ++ L P
Sbjct: 1213 NDQVLRYVIDGGVMERPENCPDKLYELMRICWQHRASARPSFIDIIRMLLP 1263
>UniRef50_UPI00006A0D3B Cluster: Tyrosine protein-kinase STYK1 (EC
2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel
oncogene with kinase domain) (Protein PK-unique).; n=1;
Xenopus tropicalis|Rep: Tyrosine protein-kinase STYK1
(EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1)
(Novel oncogene with kinase domain) (Protein PK-unique).
- Xenopus tropicalis
Length = 430
Score = 111 bits (266), Expect = 8e-23
Identities = 66/220 (30%), Positives = 104/220 (47%), Gaps = 7/220 (3%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNN 538
E + LQ + +H N++ L+G C +VLE+I+ L +RD+ +
Sbjct: 165 EIRDFLQRVAFQGWLGQHPNIVELLGCCPNEKPFCMVLENIEPGSLLHFLWDCRRDVMSM 224
Query: 539 K--FCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFG-LSHL 595
+TE +V I +QV + +LH RK+ H L RN++I N T K+ G G +
Sbjct: 225 DGILYDLTECQVYTIALQVLSALGFLHQRKLFHGDLAARNILIHRNLTAKLTGLGGACEM 284
Query: 596 RSLHETPDYT----RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVG 651
R P +W + E L + + K+DVWSFG+L++E++TLGA PY D+
Sbjct: 285 RQTGTFPSRRPAPLKWMAPERLLRLPISAKSDVWSFGILLYEMITLGAPPYPEIPPNDIL 344
Query: 652 SRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSL 691
+ RG +P ++ V CW ERP+ L
Sbjct: 345 QHLQRGNIMKRPPTCKPAMYNVMKICWLWKAPERPSLPEL 384
>UniRef50_UPI000065F647 Cluster: Ephrin type-B receptor 2 precursor
(EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3)
(DRT) (Receptor protein-tyrosine kinase HEK5) (ERK)
(Renal carcinoma antigen NY-REN-47).; n=1; Takifugu
rubripes|Rep: Ephrin type-B receptor 2 precursor (EC
2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT)
(Receptor protein-tyrosine kinase HEK5) (ERK) (Renal
carcinoma antigen NY-REN-47). - Takifugu rubripes
Length = 986
Score = 111 bits (266), Expect = 8e-23
Identities = 69/236 (29%), Positives = 117/236 (49%), Gaps = 22/236 (9%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNN 538
+++ L E ++ + +H NVI L G+ ++ ++++ E ++ + L
Sbjct: 684 QRRDFLSEASIMGQF-DHPNVIHLEGVVTKSSPVMIITEFMENGSLDAFLR--------- 733
Query: 539 KFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSH-LRS 597
SI ++++ + +A GM+YL VH+ L RN++++ N K++ FGLS L
Sbjct: 734 --VSIHGDQLVGMLRGIASGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLED 791
Query: 598 LHETPDYT---------RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNK 648
P YT RWT+ E ++ ++ +DVWS+G++MWEV++ G PY N+
Sbjct: 792 DTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQ 851
Query: 649 DVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEAPGT 704
DV + I + R P L Q+ L CWQ D + RP FS +V L P T
Sbjct: 852 DVINAIEQDYRLPPPMDCPSTLHQLMLDCWQKDRNNRPKFSQIVNNLDKMIRNPNT 907
>UniRef50_Q9Y1Y9 Cluster: Protein tyrosine kinase; n=3; Metazoa|Rep:
Protein tyrosine kinase - Ephydatia fluviatilis
Length = 2069
Score = 111 bits (266), Expect = 8e-23
Identities = 66/222 (29%), Positives = 113/222 (50%), Gaps = 18/222 (8%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNN 538
E+K+ L E L+ H N++ ++G+C N + +++E + ++L R ++
Sbjct: 1747 EQKKFLAEAALM-GNFNHPNIVKVLGVCVENDPVYIIMELMPGG--DLLHFLRDAKVERG 1803
Query: 539 KFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGT---VKIAGFGLSHL 595
+T +++QI + VA+G YL +H+ L RN ++S G VKI FGL+
Sbjct: 1804 PPL-LTVKELIQIALDVAQGCHYLQQTHFIHRDLAARNCLVSSKGADRVVKIGDFGLA-- 1860
Query: 596 RSLHETPDY---------TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSG 646
+ L+ + Y RW + E L Q ++N ++DVWSFGVLMWE++T G PY
Sbjct: 1861 KDLYSSDYYQVEGQRKLPVRWMAPEALLQGKFNMESDVWSFGVLMWEIMTFGNQPYPALN 1920
Query: 647 NKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTF 688
N++V + R +P +++Q+ CW+ ER F
Sbjct: 1921 NQEVLQFVTAEGRLQKPENCPGKIYQLMQNCWKKVASERLHF 1962
>UniRef50_Q9N3S5 Cluster: Putative uncharacterized protein; n=4;
Caenorhabditis|Rep: Putative uncharacterized protein -
Caenorhabditis elegans
Length = 618
Score = 111 bits (266), Expect = 8e-23
Identities = 83/246 (33%), Positives = 123/246 (50%), Gaps = 42/246 (17%)
Query: 476 EKTEKKQMLQELDLLIKTSEHENVISLIGICET------------NTTLLVVLEDIKKTL 523
E+ Q L+E L K S H+NVI L+ +C+T N +LL L+ + KTL
Sbjct: 363 EQLANTQFLEEAKTLTKLS-HQNVIHLLAVCDTDKPYLIITEFMTNGSLLAWLQKLTKTL 421
Query: 524 KEMLLLSRQRDIQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMII---S 580
+ L+S + +N + I QVA GM+YL KIVH+ L RN+++ S
Sbjct: 422 PPIPLMSEETGRKNVLIGA-------SISAQVASGMDYLSANKIVHRDLAARNVLVGTVS 474
Query: 581 ENGT--VKIAGFGLSHLRSLHETPDYT---------RWTSHEMLRQTRYNPKADVWSFGV 629
NG VK+A FGL+ + + +Y +W + E + +N K DVWS+G+
Sbjct: 475 SNGVPLVKVADFGLARKTDVGDE-NYVMKTDNMLPWKWMAPECFDEQIFNTKTDVWSYGI 533
Query: 630 LMWEVLTLGATPYSHSGNKDVGSRILRGM---RPS-QPSYVGDELFQVCLQCWQVDPDER 685
L+WE+ TLG TPY + + RG RP P YV ++ F++C+ +DP R
Sbjct: 534 LLWEIGTLGKTPYRGWDYEGTLEHLSRGYVLPRPELVPDYVYEDAFKICV---HLDPRRR 590
Query: 686 PTFSSL 691
PTF L
Sbjct: 591 PTFDRL 596
>UniRef50_Q7Z1D3 Cluster: Focal adhesion kinase; n=1; Lytechinus
variegatus|Rep: Focal adhesion kinase - Lytechinus
variegatus (Sea urchin)
Length = 1006
Score = 111 bits (266), Expect = 8e-23
Identities = 70/236 (29%), Positives = 110/236 (46%), Gaps = 23/236 (9%)
Query: 477 KTEKKQMLQELDL----LIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQ 532
K E Q L E L ++K +H ++I LIG+C T+ + +V+E M L + +
Sbjct: 472 KVESTQALGERFLEEAYIMKQFDHPHIIKLIGVC-TDPPIWIVMELAPFGEMRMFLQTHK 530
Query: 533 RDIQNNKFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGL 592
++ T ++ Q++ + YL ++K VH+ + RN+++ VK+ FGL
Sbjct: 531 EEL--------TLASLILYAYQLSMALSYLESKKFVHRDIAARNLLVVAKDNVKLGDFGL 582
Query: 593 SHLRSLHETPDYT--------RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSH 644
S L LH+ Y +W + E + R+ +DVW FGV MWE+L G P+
Sbjct: 583 SRL--LHDHSYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMYGVKPFQG 640
Query: 645 SGNKDVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSE 700
N +V RI G R P+ L+ V CW +P +RP F L L E
Sbjct: 641 VKNNEVIGRIENGERLPMPAACPPTLYSVMTLCWSYEPSKRPNFKDLKTRLNEILE 696
>UniRef50_Q7YZH5 Cluster: MBTK3; n=1; Monosiga brevicollis|Rep:
MBTK3 - Monosiga brevicollis
Length = 357
Score = 111 bits (266), Expect = 8e-23
Identities = 68/216 (31%), Positives = 111/216 (51%), Gaps = 20/216 (9%)
Query: 496 HENVISLIGICETNTTLLVVLEDIKK-TLKEMLLLSRQRDIQNNKFCSITENKVLQICVQ 554
H ++ L+G+ L V+E +K L+E+L +++ ++ + + L VQ
Sbjct: 130 HNCLVQLLGVSMQQRPWLCVIEFMKYGDLREVLKTCKEKSLR------LAYLEQLAFAVQ 183
Query: 555 VARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSH----------LRSLHETPDY 604
++RGM ++ ++ VH L RN++ISE K+A FGL+ LR + P
Sbjct: 184 ISRGMAFIAQQRYVHMDLAARNVLISEGNRCKVADFGLTRRYDPGKDTYTLRKTAKLP-- 241
Query: 605 TRWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRILRGMRPSQP- 663
RW + E ++ ++ K+DVW+FGV + E+ GA PY+ N+DV IL G R ++P
Sbjct: 242 IRWMAIEAMKTKVFSEKSDVWAFGVTLHEIAAYGALPYAGVKNRDVSKHILDGNRLAKPE 301
Query: 664 SYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFS 699
+ D+ F + CWQ DP RPTF L F+
Sbjct: 302 DGMQDDFFALAESCWQDDPAVRPTFKEATKSLEGFA 337
>UniRef50_Q6VU50 Cluster: Eph receptor; n=3; Endopterygota|Rep: Eph
receptor - Manduca sexta (Tobacco hawkmoth) (Tobacco
hornworm)
Length = 1011
Score = 111 bits (266), Expect = 8e-23
Identities = 70/220 (31%), Positives = 112/220 (50%), Gaps = 20/220 (9%)
Query: 495 EHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNNKFCSITENKVLQICVQ 554
EH NVI L G+ ++++ E ++ + L R D KF + +++ +
Sbjct: 705 EHPNVIFLQGVVTKCNPIMIITEFMENGSLDTFL--RAND---GKFMVL---QLVGMLRG 756
Query: 555 VARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSLHETPD--YT------- 605
+A GM+YL +H+ L RN++++ + KIA FGLS R + T D YT
Sbjct: 757 IATGMQYLSEMNYIHRDLAARNVLVNSHLVCKIADFGLS--REIESTADGAYTTRGGKIP 814
Query: 606 -RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNKDVGSRILRGMRPSQPS 664
RWT+ E + ++ +DVWS G++ WEV++ G PY + N+DV I +G R P
Sbjct: 815 VRWTAPEAIAFRKFTSASDVWSMGIVCWEVMSFGERPYWNWSNQDVIKSIEKGYRLPAPM 874
Query: 665 YVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEAPGT 704
+ ++Q+ L CWQ + RPTF+S+V L P T
Sbjct: 875 DCPEAVYQLMLDCWQKERTHRPTFASIVKTLDKLIGYPDT 914
>UniRef50_Q4SQX3 Cluster: Chromosome 11 SCAF14528, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 11 SCAF14528, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 780
Score = 110 bits (265), Expect = 1e-22
Identities = 72/234 (30%), Positives = 117/234 (50%), Gaps = 21/234 (8%)
Query: 479 EKKQMLQELDLLIKTSEHENVISLIGICETNTTLLVVLEDIKKTLKEMLLLSRQRDIQNN 538
+K+ L E ++ + +H NVI L G+ + ++++ E ++ + L R+ D Q
Sbjct: 457 QKRDFLAEASIMAQF-DHPNVIRLEGVVTHSKPVMIITEYMENGSLDSFL--RRHDGQ-- 511
Query: 539 KFCSITENKVLQICVQVARGMEYLHTRKIVHKKLCCRNMIISENGTVKIAGFGLSHLRSL 598
T +++ + +A GM YL +H+ L RN++++ N K++ FGLS R L
Sbjct: 512 ----FTIIQLVGLLRGIAAGMTYLSDLGYIHRDLAARNILVNSNLVCKVSDFGLS--RVL 565
Query: 599 HETPD--YT--------RWTSHEMLRQTRYNPKADVWSFGVLMWEVLTLGATPYSHSGNK 648
+ PD YT RWT+ E + +++ +DVWS+GV+MWEV + G PY + N+
Sbjct: 566 EDDPDAAYTTSGGKIPIRWTAPEAITFRKFSSSSDVWSYGVVMWEVTSYGERPYWNLTNR 625
Query: 649 DVGSRILRGMRPSQPSYVGDELFQVCLQCWQVDPDERPTFSSLVIELTPFSEAP 702
DV + G R P L + L CWQ D +ERP F +V L P
Sbjct: 626 DVIKSVEEGYRLPAPMGCPAALHTLMLDCWQKDRNERPRFCQIVTVLDKLIRNP 679
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.319 0.136 0.409
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 800,999,511
Number of Sequences: 1657284
Number of extensions: 33770451
Number of successful extensions: 97423
Number of sequences better than 10.0: 500
Number of HSP's better than 10.0 without gapping: 3588
Number of HSP's successfully gapped in prelim test: 5214
Number of HSP's that attempted gapping in prelim test: 82177
Number of HSP's gapped (non-prelim): 12180
length of query: 728
length of database: 575,637,011
effective HSP length: 106
effective length of query: 622
effective length of database: 399,964,907
effective search space: 248778172154
effective search space used: 248778172154
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
S2: 76 (34.7 bits)
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