Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA000725-TA|BGIBMGA000725-PA|IPR001140|ABC transporter,
transmembrane region, IPR003439|ABC transporter related, IPR011527|ABC
transporter, transmembrane region, type 1, IPR003593|AAA ATPase
(1149 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
M29447-1|AAA59576.1| 1280|Homo sapiens P glycoprotein protein. 781 0.0
AY910577-1|AAW82430.1| 1280|Homo sapiens ATP-binding cassette, s... 781 0.0
BC130424-1|AAI30425.1| 1280|Homo sapiens ATP-binding cassette, s... 780 0.0
M14758-1|AAA59575.1| 1280|Homo sapiens PGY1 protein. 777 0.0
AF016535-1|AAB69423.1| 1279|Homo sapiens P-glycoprotein protein. 777 0.0
AB208970-1|BAD92207.1| 1062|Homo sapiens Multidrug resistance pr... 727 0.0
M23234-1|AAA36207.1| 1279|Homo sapiens protein ( Human membrane ... 466 e-130
EF034088-1|ABJ53424.1| 1286|Homo sapiens ATP-binding cassette, s... 466 e-130
BC042531-1|AAH42531.1| 1286|Homo sapiens ATP-binding cassette, s... 465 e-130
AF136523-1|AAD28285.1| 1321|Homo sapiens bile salt export pump p... 442 e-123
AF091582-1|AAC77455.1| 1321|Homo sapiens bile salt export pump p... 442 e-123
AC008177-1|AAY24305.1| 870|Homo sapiens unknown protein. 442 e-123
BC104920-1|AAI04921.1| 812|Homo sapiens ATP-binding cassette, s... 346 2e-94
BC104894-1|AAI04895.2| 812|Homo sapiens ATP-binding cassette, s... 346 2e-94
AY234788-1|AAO73470.1| 812|Homo sapiens P-glycoprotein ABCB5 pr... 346 3e-94
AY090613-1|AAM09027.1| 812|Homo sapiens P-glycoprotein protein. 346 3e-94
AF399931-1|AAQ03033.1| 832|Homo sapiens P-glycoprotein protein. 346 3e-94
AF319622-1|AAN76500.1| 681|Homo sapiens P-glycoprotein protein. 346 3e-94
AY851365-1|AAW31630.1| 812|Homo sapiens ABCB5beta protein. 343 2e-93
AC069137-4|AAY24100.1| 451|Homo sapiens unknown protein. 332 3e-90
AK094636-1|BAC04392.1| 701|Homo sapiens protein ( Homo sapiens ... 319 4e-86
BC141814-1|AAI41815.1| 718|Homo sapiens ATP-binding cassette, s... 318 6e-86
AK222911-1|BAD96631.1| 718|Homo sapiens ATP-binding cassette, s... 318 6e-86
AK002018-1|BAA92038.1| 735|Homo sapiens protein ( Homo sapiens ... 318 6e-86
X06181-1|CAA29547.1| 431|Homo sapiens P-glycoprotein (431 AA) p... 317 1e-85
AF047690-1|AAD15748.1| 718|Homo sapiens ATP-binding cassette pr... 315 7e-85
BC064930-1|AAH64930.1| 738|Homo sapiens ATP-binding cassette, s... 313 2e-84
AL121990-4|CAI22012.1| 738|Homo sapiens ATP-binding cassette, s... 313 2e-84
AF216833-1|AAF78198.1| 738|Homo sapiens M-ABC2 protein protein. 308 6e-83
AB013380-1|BAB20265.1| 737|Homo sapiens mono ATP-binding casset... 301 1e-80
AK172794-1|BAD18770.1| 433|Homo sapiens protein ( Homo sapiens ... 292 5e-78
BC141836-1|AAI41837.1| 693|Homo sapiens Unknown (protein for MG... 280 2e-74
AC006154-1|AAD05023.1| 407|Homo sapiens unknown protein. 258 1e-67
AY523970-1|AAS55411.1| 748|Homo sapiens TAP1 protein. 253 2e-66
AF216494-1|AAF89993.1| 766|Homo sapiens ATP-binding cassette pr... 252 7e-66
AB177852-1|BAD66830.1| 796|Homo sapiens KIAA1520 splice variant... 252 7e-66
AB045381-1|BAA97989.2| 766|Homo sapiens TAPL protein. 252 7e-66
AB040953-1|BAA96044.2| 810|Homo sapiens KIAA1520 protein protein. 252 7e-66
L21206-1|AAC12904.1| 748|Homo sapiens peptide transporter protein. 251 9e-66
L21205-1|AAC12903.1| 748|Homo sapiens peptide transporter protein. 251 9e-66
AY523971-1|AAS55412.1| 748|Homo sapiens TAP1 protein. 251 9e-66
L21207-1|AAC12905.1| 748|Homo sapiens peptide transporter protein. 250 2e-65
BC064384-1|AAH64384.1| 769|Homo sapiens ABCB9 protein protein. 249 5e-65
L21208-1|AAC12906.1| 748|Homo sapiens peptide transporter protein. 248 7e-65
X87344-5|CAA60785.1| 748|Homo sapiens TAP1 protein. 248 9e-65
X66401-2|CAA47025.1| 748|Homo sapiens ABC-transporter protein. 248 9e-65
X57522-1|CAA40741.1| 808|Homo sapiens peptide transporter protein. 248 9e-65
L21204-1|AAC12902.1| 748|Homo sapiens peptide transporter protein. 248 9e-65
BX088556-4|CAM26263.1| 808|Homo sapiens transporter 1 ATP-bindi... 248 9e-65
BC014081-1|AAH14081.1| 808|Homo sapiens transporter 1, ATP-bind... 248 9e-65
AL935043-6|CAI18626.1| 808|Homo sapiens transporter 1, ATP-bind... 248 9e-65
AL671681-12|CAI17714.1| 808|Homo sapiens transporter 1, ATP-bin... 248 9e-65
AL669918-8|CAI18140.1| 808|Homo sapiens transporter 1, ATP-bind... 248 9e-65
AK074738-1|BAC11171.1| 472|Homo sapiens protein ( Homo sapiens ... 243 3e-63
X87344-8|CAA60788.1| 686|Homo sapiens TAP2 protein. 240 2e-62
X66401-4|CAA47027.1| 686|Homo sapiens TAP2 protein. 240 2e-62
U07844-1|AAA79901.1| 622|Homo sapiens ABC transport protein pro... 240 2e-62
M74447-1|AAA59841.1| 703|Homo sapiens PSF-2 protein. 240 2e-62
BT009906-1|AAP88908.1| 686|Homo sapiens transporter 2, ATP-bind... 240 2e-62
AL935043-2|CAI18622.1| 686|Homo sapiens transporter 2, ATP-bind... 240 2e-62
AL671681-8|CAI17711.1| 686|Homo sapiens transporter 2, ATP-bind... 240 2e-62
AL669918-4|CAI18137.1| 686|Homo sapiens transporter 2, ATP-bind... 240 2e-62
Z22935-1|CAA80522.1| 703|Homo sapiens TAP2B protein. 239 3e-62
BX682530-4|CAI41935.1| 703|Homo sapiens transporter 2 ATP-bindi... 239 3e-62
AK222823-1|BAD96543.1| 703|Homo sapiens transporter 2, ATP-bind... 239 3e-62
AB208953-1|BAD92190.1| 704|Homo sapiens transporter 2, ATP-bind... 239 3e-62
AB073779-1|BAB71769.1| 703|Homo sapiens ABC-transporter protein. 239 3e-62
AF100418-1|AAD23381.1| 483|Homo sapiens TAP2 protein protein. 239 5e-62
Z22936-1|CAA80523.1| 686|Homo sapiens TAP2E protein. 238 7e-62
AF136750-1|AAD23601.1| 483|Homo sapiens TAP2 protein protein. 237 2e-61
BT009918-1|AAP88920.1| 753|Homo sapiens ATP-binding cassette, s... 233 3e-60
BC006323-1|AAH06323.1| 753|Homo sapiens ATP-binding cassette, s... 233 3e-60
AL360179-2|CAH70565.1| 752|Homo sapiens ATP-binding cassette, s... 233 3e-60
AL360179-1|CAH70564.1| 753|Homo sapiens ATP-binding cassette, s... 233 3e-60
AL359545-2|CAI41573.1| 752|Homo sapiens ATP-binding cassette, s... 233 3e-60
AL359545-1|CAI41574.1| 753|Homo sapiens ATP-binding cassette, s... 233 3e-60
AF241887-1|AAK20173.1| 752|Homo sapiens ATP binding cassette 7 ... 233 3e-60
AF133659-1|AAD33045.1| 752|Homo sapiens ATP-binding cassette 7 ... 233 3e-60
AF078777-1|AAD47141.1| 748|Homo sapiens ABC transporter protein. 233 4e-60
AK223300-1|BAD97020.1| 703|Homo sapiens transporter 2, ATP-bind... 231 8e-60
AB005289-1|BAA28861.1| 752|Homo sapiens ABC transporter 7 prote... 229 3e-59
BC000559-1|AAH00559.1| 842|Homo sapiens ATP-binding cassette, s... 229 6e-59
AK057026-1|BAB71347.1| 766|Homo sapiens protein ( Homo sapiens ... 229 6e-59
AJ289233-1|CAB95766.2| 842|Homo sapiens ABC transporter umat pr... 229 6e-59
AF308472-1|AAG33617.1| 896|Homo sapiens ATP-binding cassette ha... 229 6e-59
AF076775-1|AAF75107.1| 842|Homo sapiens MT-ABC transporter prot... 229 6e-59
AF070598-1|AAC28653.1| 511|Homo sapiens ABC transporter protein. 229 6e-59
AB039371-1|BAA96733.1| 842|Homo sapiens mitochondrial ABC trans... 229 6e-59
BC043423-1|AAH43423.1| 301|Homo sapiens ABCB6 protein protein. 225 7e-58
AF176984-1|AAD50509.1| 372|Homo sapiens TAP2 protein protein. 223 3e-57
AK172812-1|BAD18782.1| 571|Homo sapiens protein ( Homo sapiens ... 223 4e-57
AF105151-1|AAD12059.1| 653|Homo sapiens Tap2 transporter isofor... 218 8e-56
BX682530-5|CAI41936.1| 653|Homo sapiens transporter 2 ATP-bindi... 218 1e-55
BX296564-5|CAI41937.1| 653|Homo sapiens transporter 2 ATP-bindi... 218 1e-55
AL935043-1|CAI18621.1| 653|Homo sapiens transporter 2, ATP-bind... 218 1e-55
AL671681-7|CAI17710.1| 653|Homo sapiens transporter 2, ATP-bind... 218 1e-55
AL669918-3|CAI18136.1| 653|Homo sapiens transporter 2, ATP-bind... 218 1e-55
AF078671-1|AAD31384.1| 653|Homo sapiens transporter 2 isoform p... 218 1e-55
U18237-1|AAA84438.1| 229|Homo sapiens ATP-binding cassette prot... 211 1e-53
AB112583-1|BAC98410.1| 681|Homo sapiens TAP-Like isoform 12C pr... 202 4e-51
AB112582-1|BAC98409.1| 683|Homo sapiens TAP-Like isoform 12B pr... 202 4e-51
Y17151-1|CAA76658.2| 1527|Homo sapiens multidrug resistance prot... 161 2e-38
AF154001-1|AAD38185.1| 285|Homo sapiens MRP3s1 protein protein. 161 2e-38
AF104943-1|AAD04170.1| 1527|Homo sapiens ABC transporter MOAT-D ... 161 2e-38
AF085690-1|AAD02845.1| 1527|Homo sapiens multidrug resistance-as... 161 2e-38
AF009670-1|AAD01430.1| 1528|Homo sapiens MRP3 protein. 161 2e-38
AB208954-1|BAD92191.1| 1533|Homo sapiens ATP-binding cassette, s... 161 2e-38
AB010887-1|BAA28146.1| 1527|Homo sapiens multidrug resistance-as... 161 2e-38
AF083552-1|AAC34668.1| 1527|Homo sapiens canalicular multispecif... 159 4e-38
BC131732-1|AAI31733.1| 1503|Homo sapiens ATP-binding cassette, s... 156 5e-37
AF076622-1|AAC79696.1| 1503|Homo sapiens MRP6 protein. 156 5e-37
AF168791-1|AAD51293.1| 1503|Homo sapiens multi-specific organic ... 155 9e-37
X95715-1|CAA65019.1| 453|Homo sapiens anthracycline resistance ... 155 1e-36
U83659-1|AAB71756.1| 485|Homo sapiens multidrug resistance-asso... 153 3e-36
U49248-1|AAB09422.1| 1545|Homo sapiens canalicular multispecific... 153 5e-36
X96395-1|CAA65259.2| 1545|Homo sapiens canalicular multidrug res... 152 6e-36
U63970-1|AAB39892.1| 1545|Homo sapiens canalicular multispecific... 152 6e-36
AL392107-3|CAI11010.1| 1545|Homo sapiens ATP-binding cassette, s... 152 6e-36
AL133353-7|CAI14502.1| 1545|Homo sapiens ATP-binding cassette, s... 152 6e-36
AY040220-1|AAK76740.1| 1359|Homo sapiens ATP-binding cassette tr... 151 2e-35
U83661-1|AAB71758.2| 1437|Homo sapiens multidrug resistance prot... 149 4e-35
L78243-2|AAB02418.1| 1582|Homo sapiens SUR1 protein. 149 4e-35
L78243-1|AAB02417.1| 1581|Homo sapiens SUR1 protein. 149 4e-35
L78207-1|AAB02278.1| 1581|Homo sapiens sulfonylurea receptor pro... 149 4e-35
AY196484-1|AAO49801.1| 1394|Homo sapiens ATP-binding cassette C5... 149 4e-35
AL833963-1|CAD38811.1| 453|Homo sapiens hypothetical protein pr... 149 4e-35
AJ132244-1|CAB45309.1| 1545|Homo sapiens multidrug resistance pr... 149 4e-35
AF146074-1|AAD37716.1| 1437|Homo sapiens ABC protein protein. 149 4e-35
AF104942-1|AAD04169.1| 1437|Homo sapiens ABC transporter MOAT-C ... 149 4e-35
AF087138-1|AAC36724.1| 1581|Homo sapiens sulfonylurea receptor 1... 149 4e-35
AB209454-1|BAD92691.1| 1430|Homo sapiens Multidrug resistance-as... 149 4e-35
L05628-1|AAB46616.1| 1531|Homo sapiens multidrug resistance-asso... 148 1e-34
EF419769-1|ABN79590.1| 1531|Homo sapiens ATP-binding cassette, s... 148 1e-34
AF022853-5|AAB83982.1| 1400|Homo sapiens multidrug resistance pr... 148 1e-34
AF022853-4|AAB83981.1| 1456|Homo sapiens multidrug resistance pr... 148 1e-34
AF022853-3|AAB83980.1| 1459|Homo sapiens multidrug resistance pr... 148 1e-34
AF022853-1|AAB83979.1| 1515|Homo sapiens multidrug resistance pr... 148 1e-34
AB209120-1|BAD92357.1| 1439|Homo sapiens ATP-binding cassette, s... 148 1e-34
U63455-1|AAB36700.1| 1581|Homo sapiens sulfonylurea receptor pro... 147 2e-34
U63421-1|AAB36699.1| 1581|Homo sapiens sulfonylurea receptor pro... 147 2e-34
AB019002-1|BAA76608.1| 1437|Homo sapiens MRP5 protein. 147 2e-34
AB005659-1|BAA22887.1| 946|Homo sapiens SMRP protein. 147 2e-34
AF352582-1|AAK19755.1| 1382|Homo sapiens ATP-binding cassette tr... 146 3e-34
AF061324-1|AAC16058.1| 1549|Homo sapiens sulfonylurea receptor 2... 146 4e-34
U91318-1|AAC15784.1| 401|Homo sapiens Multiple drug resistance ... 146 5e-34
BC001636-1|AAH01636.1| 316|Homo sapiens Unknown (protein for IM... 146 5e-34
AY490254-1|AAR99172.1| 164|Homo sapiens P-glycoprotein protein. 145 7e-34
BC024103-1|AAH24103.1| 282|Homo sapiens ABCC10 protein protein. 145 9e-34
AL359813-2|CAI23217.1| 1492|Homo sapiens ATP-binding cassette, s... 145 9e-34
AL133613-1|CAB63742.1| 700|Homo sapiens hypothetical protein pr... 145 9e-34
AK024446-1|BAB15736.1| 706|Homo sapiens FLJ00036 protein protein. 145 9e-34
AK000002-1|BAA92227.1| 1513|Homo sapiens FLJ00002 protein protein. 145 9e-34
AY040219-1|AAK76739.1| 1382|Homo sapiens ATP-binding cassette tr... 144 1e-33
AF367202-1|AAK58869.1| 1382|Homo sapiens ATP-binding cassette pr... 144 1e-33
AF061323-1|AAC16057.1| 1549|Homo sapiens sulfonylurea receptor 2... 144 1e-33
AY032599-1|AAK39642.1| 1463|Homo sapiens multidrug resistance-as... 142 5e-33
AF071203-1|AAC27077.1| 893|Homo sapiens ABC transporter MOAT-B ... 142 9e-33
AF071202-1|AAC27076.1| 1325|Homo sapiens ABC transporter MOAT-B ... 142 9e-33
AY207008-1|AAO37649.1| 1325|Homo sapiens ATP-binding cassette tr... 141 1e-32
AY081219-1|AAL88745.1| 1325|Homo sapiens multidrug resistance-as... 141 1e-32
AL356257-1|CAI16722.1| 1325|Homo sapiens ATP-binding cassette, s... 141 1e-32
AL157818-1|CAC36037.2| 1325|Homo sapiens ATP-binding cassette, s... 141 1e-32
AL139381-1|CAI16589.1| 1325|Homo sapiens ATP-binding cassette, s... 141 1e-32
AF541977-1|AAN17334.1| 1278|Homo sapiens ATP-binding cassette pr... 141 1e-32
AJ294545-1|CAC69553.1| 1514|Homo sapiens multidrug resistance as... 139 6e-32
AY851364-1|AAW31629.1| 131|Homo sapiens ABCB5alpha protein. 136 6e-31
L40625-1|AAA99227.1| 395|Homo sapiens sulfonylurea receptor pro... 132 7e-30
AL122095-1|CAB59263.1| 216|Homo sapiens hypothetical protein pr... 132 9e-30
AF411578-1|AAL99901.1| 1009|Homo sapiens ATP-binding cassette pr... 126 3e-28
AF411577-1|AAL99900.1| 1009|Homo sapiens ATP-binding cassette pr... 126 3e-28
AF395909-1|AAL79529.1| 935|Homo sapiens ATP-binding cassette pr... 126 3e-28
AF395908-1|AAL79528.1| 1009|Homo sapiens ATP-binding cassette pr... 126 3e-28
AY196326-1|AAO40749.1| 930|Homo sapiens truncated ABCC12 protei... 124 1e-27
M55131-1|AAC13657.1| 1480|Homo sapiens cystic fibrosis transmemb... 122 7e-27
M28668-1|AAA35680.1| 1480|Homo sapiens protein ( Human cystic fi... 122 7e-27
DQ388145-1|ABD72217.1| 1480|Homo sapiens cystic fibrosis transme... 122 7e-27
DQ388143-1|ABD72213.1| 1480|Homo sapiens cystic fibrosis transme... 122 7e-27
DQ388142-1|ABD72211.1| 1480|Homo sapiens cystic fibrosis transme... 122 7e-27
DQ388141-1|ABD72209.1| 1480|Homo sapiens cystic fibrosis transme... 122 7e-27
DQ388140-1|ABD72207.1| 1480|Homo sapiens cystic fibrosis transme... 122 7e-27
DQ388139-1|ABD72205.1| 1480|Homo sapiens cystic fibrosis transme... 122 7e-27
DQ388138-1|ABD72203.1| 1480|Homo sapiens cystic fibrosis transme... 122 7e-27
DQ388137-1|ABD72201.1| 1480|Homo sapiens cystic fibrosis transme... 122 7e-27
DQ388135-1|ABD72197.1| 1480|Homo sapiens cystic fibrosis transme... 122 7e-27
DQ388134-1|ABD72195.1| 1480|Homo sapiens cystic fibrosis transme... 122 7e-27
DQ388133-1|ABD72193.1| 1480|Homo sapiens cystic fibrosis transme... 122 7e-27
DQ388132-1|ABD72191.1| 1480|Homo sapiens cystic fibrosis transme... 122 7e-27
DQ388131-1|ABD72189.1| 1480|Homo sapiens cystic fibrosis transme... 122 7e-27
DQ388130-1|ABD72187.1| 1480|Homo sapiens cystic fibrosis transme... 122 7e-27
DQ388129-1|ABD72185.1| 1480|Homo sapiens cystic fibrosis transme... 122 7e-27
DQ388128-1|ABD72183.1| 1480|Homo sapiens cystic fibrosis transme... 122 7e-27
DQ356264-1|ABC87067.1| 1480|Homo sapiens cystic fibrosis transme... 122 7e-27
DQ356263-1|ABC87065.1| 1480|Homo sapiens cystic fibrosis transme... 122 7e-27
DQ356262-1|ABC87063.1| 1480|Homo sapiens cystic fibrosis transme... 122 7e-27
DQ356261-1|ABC87061.1| 1462|Homo sapiens cystic fibrosis transme... 122 7e-27
DQ356260-1|ABC87059.1| 1480|Homo sapiens cystic fibrosis transme... 122 7e-27
DQ356259-1|ABC87057.1| 1480|Homo sapiens cystic fibrosis transme... 122 7e-27
DQ356258-1|ABC87055.1| 1462|Homo sapiens cystic fibrosis transme... 122 7e-27
DQ356257-1|ABC87053.1| 1480|Homo sapiens cystic fibrosis transme... 122 7e-27
DQ354391-1|ABC79056.1| 1480|Homo sapiens cystic fibrosis transme... 122 7e-27
DQ354390-1|ABC79054.1| 1480|Homo sapiens cystic fibrosis transme... 122 7e-27
DQ354389-1|ABC79052.1| 1480|Homo sapiens cystic fibrosis transme... 122 7e-27
DQ354388-1|ABC79050.1| 1480|Homo sapiens cystic fibrosis transme... 122 7e-27
AC000061-1|AAB46340.2| 484|Homo sapiens unknown protein. 122 7e-27
L09191-1|AAA58648.1| 129|Homo sapiens TAP2 protein. 119 7e-26
AB209103-1|BAD92340.1| 799|Homo sapiens ATP-binding cassette C5... 118 2e-25
L10287-1|AAA58649.1| 129|Homo sapiens TAP2 protein. 117 2e-25
AY848829-1|AAW33656.1| 258|Homo sapiens cystic fibrosis transme... 115 9e-25
AB208973-1|BAD92210.1| 776|Homo sapiens ABCC4 protein variant p... 114 2e-24
BC041560-1|AAH41560.1| 859|Homo sapiens ABCC4 protein protein. 112 6e-24
AF022853-2|AAB83983.1| 1450|Homo sapiens multidrug resistance pr... 112 6e-24
AF411579-1|AAL99902.1| 1344|Homo sapiens ATP-binding cassette pr... 111 1e-23
AC003026-1|AAC05808.1| 691|Homo sapiens Multiple drug resistanc... 108 1e-22
AY848830-1|AAW33657.1| 241|Homo sapiens cystic fibrosis transme... 107 3e-22
X57521-1|CAA40740.1| 430|Homo sapiens Y3 protein. 105 1e-21
U91318-3|AAC15785.1| 848|Homo sapiens Gene product with similar... 103 5e-21
AL359813-4|CAI23219.1| 172|Homo sapiens ATP-binding cassette, s... 98 1e-19
BC017348-1|AAH17348.1| 596|Homo sapiens ABCB9 protein protein. 96 7e-19
AL359813-5|CAI23220.1| 157|Homo sapiens ATP-binding cassette, s... 95 2e-18
AB209084-1|BAD92321.1| 1011|Homo sapiens Sulfonylurea receptor 1... 92 9e-18
AB012959-1|BAA88711.1| 63|Homo sapiens sister p-glycoprotein p... 92 9e-18
AF085691-1|AAD02846.1| 1238|Homo sapiens multidrug resistance-as... 91 2e-17
S83249-1|AAP31917.1| 125|Homo sapiens transporter protein/putat... 89 8e-17
DQ388144-1|ABD72215.1| 1480|Homo sapiens cystic fibrosis transme... 87 3e-16
AC000111-1|AAB46352.1| 996|Homo sapiens unknown protein. 87 3e-16
U83660-1|AAB71757.1| 162|Homo sapiens multidrug resistance-asso... 85 2e-15
BC125232-1|AAI25233.1| 1500|Homo sapiens ABCA6 protein protein. 82 1e-14
BC125231-1|AAI25232.1| 1500|Homo sapiens ABCA6 protein protein. 82 1e-14
AY028898-1|AAK30023.1| 1617|Homo sapiens ATP-binding cassette A6... 82 1e-14
AK094171-1|BAC04300.1| 120|Homo sapiens protein ( Homo sapiens ... 82 1e-14
AF373328-1|AAM77558.1| 1617|Homo sapiens ABC transporter ABCA6 p... 82 1e-14
AF373290-1|AAM77557.1| 1617|Homo sapiens ABC transporter ABCA6 p... 82 1e-14
BC130280-1|AAI30281.1| 1621|Homo sapiens ABCA8 protein protein. 79 9e-14
X97187-1|CAA65825.1| 1704|Homo sapiens ABC-C transporter protein. 77 3e-13
U78735-1|AAC50967.1| 1704|Homo sapiens ABC3 protein. 77 3e-13
DQ073080-1|AAY57325.1| 1704|Homo sapiens ATP-binding cassette, s... 77 3e-13
AB210044-1|BAE06126.1| 1708|Homo sapiens ABCA3 variant protein p... 77 3e-13
AB070929-1|BAB86781.1| 1704|Homo sapiens lamellar body membrane ... 77 3e-13
Y15635-1|CAA75729.1| 2273|Homo sapiens ABCR protein. 77 4e-13
U88667-1|AAC51144.1| 2273|Homo sapiens ATP-binding cassette tran... 77 4e-13
AF001945-1|AAC05632.1| 2273|Homo sapiens rim ABC transporter pro... 77 4e-13
AF000148-1|AAC23915.1| 2273|Homo sapiens ATP-binding cassette tr... 77 4e-13
AB210040-1|BAE06122.1| 2303|Homo sapiens ABCA4 variant protein p... 77 4e-13
X91249-1|CAA62631.1| 674|Homo sapiens white protein. 76 6e-13
BC029158-1|AAH29158.2| 666|Homo sapiens ATP-binding cassette, s... 76 6e-13
AP001746-1|BAA95530.1| 674|Homo sapiens white protein homolog (... 76 6e-13
AJ289137-1|CAC00730.1| 674|Homo sapiens ATP-binding cassette tr... 76 6e-13
AF323658-3|AAK28837.1| 662|Homo sapiens ATP-binding cassette tr... 76 6e-13
AB038161-1|BAB13728.2| 674|Homo sapiens ABC transporter protein. 76 6e-13
AF323664-1|AAK28842.1| 677|Homo sapiens ATP-binding cassette tr... 76 8e-13
AF323663-1|AAK28841.1| 662|Homo sapiens ATP-binding cassette tr... 76 8e-13
AF323662-1|AAK28840.1| 663|Homo sapiens ATP-binding cassette tr... 76 8e-13
AF323660-1|AAK28838.1| 668|Homo sapiens ATP-binding cassette tr... 76 8e-13
AF323658-5|AAK28834.1| 644|Homo sapiens ATP-binding cassette tr... 76 8e-13
AF323658-4|AAK28836.1| 677|Homo sapiens ATP-binding cassette tr... 76 8e-13
AF323658-2|AAK28835.1| 663|Homo sapiens ATP-binding cassette tr... 76 8e-13
AF323658-1|AAK28833.1| 668|Homo sapiens ATP-binding cassette tr... 76 8e-13
AY219711-1|AAP21093.1| 2595|Homo sapiens ABCA12 transporter subf... 75 1e-12
AY033486-1|AAK54355.1| 2277|Homo sapiens ATP-binding cassette tr... 75 1e-12
AL359846-6|CAH73579.1| 2261|Homo sapiens ATP-binding cassette, s... 75 1e-12
AL353685-3|CAH72444.1| 2261|Homo sapiens ATP-binding cassette, s... 75 1e-12
AK130814-1|BAC85435.1| 546|Homo sapiens protein ( Homo sapiens ... 75 1e-12
AJ012376-1|CAA10005.1| 2201|Homo sapiens ATP-binding cassette tr... 75 1e-12
AF418105-1|AAN40735.1| 2347|Homo sapiens ATP-binding cassette tr... 75 1e-12
AF323661-1|AAK28839.1| 644|Homo sapiens ATP-binding cassette tr... 75 1e-12
AF285167-1|AAF98175.1| 2261|Homo sapiens ATP-binding cassette tr... 75 1e-12
AF275948-1|AAF86276.1| 2261|Homo sapiens ABCA1 protein. 75 1e-12
AF165281-1|AAD49849.1| 2201|Homo sapiens ATP cassette binding tr... 75 1e-12
AC072062-1|AAY24276.1| 2413|Homo sapiens unknown protein. 75 1e-12
AB055982-1|BAB63210.1| 2261|Homo sapiens ABCA1 protein. 75 1e-12
AF287262-1|AAK43526.1| 2261|Homo sapiens ATP-binding cassette 1 ... 75 2e-12
BX640746-1|CAE45856.1| 431|Homo sapiens hypothetical protein pr... 74 3e-12
AY028897-1|AAK30022.1| 1642|Homo sapiens ATP-binding cassette A5... 74 3e-12
AJ512612-1|CAD54757.1| 925|Homo sapiens ABCA5 transporter protein. 74 3e-12
AJ275973-1|CAB93535.3| 1642|Homo sapiens ATP-binding cassette pr... 74 3e-12
U34919-1|AAC51098.1| 638|Homo sapiens white homolog protein. 73 6e-12
AY028899-1|AAK30024.1| 1624|Homo sapiens ATP-binding cassette A9... 73 6e-12
AK074491-1|BAC11021.1| 483|Homo sapiens protein ( Homo sapiens ... 73 6e-12
AK057068-1|BAB71359.1| 856|Homo sapiens protein ( Homo sapiens ... 73 6e-12
AF423346-1|AAN32752.1| 1624|Homo sapiens ATP-binding cassette su... 73 6e-12
AF423307-1|AAN32751.1| 1624|Homo sapiens ATP-binding cassette su... 73 6e-12
AL807752-22|CAI12768.1| 2435|Homo sapiens ATP-binding cassette, ... 72 1e-11
AF327705-1|AAK14335.1| 2436|Homo sapiens ABC transporter ABCA2 p... 72 1e-11
AF327657-1|AAK14334.1| 2436|Homo sapiens ABC transporter ABCA2 p... 72 1e-11
AF178941-1|AAG09372.1| 2436|Homo sapiens ATP-binding cassette su... 72 1e-11
AB177854-1|BAD66832.1| 1440|Homo sapiens KIAA1062 splice variant... 72 1e-11
AB028985-1|BAA83014.2| 1771|Homo sapiens KIAA1062 protein protein. 72 1e-11
AY204751-1|AAP13576.1| 5058|Homo sapiens ABC A13 protein. 72 1e-11
AK131360-1|BAD18512.1| 1186|Homo sapiens mRNA. protein. 72 1e-11
AF501281-1|AAO59914.1| 2127|Homo sapiens ATP binding cassette tr... 72 1e-11
AY247105-1|AAO72160.1| 1543|Homo sapiens ATP-binding cassette su... 71 2e-11
AY247065-1|AAO72161.1| 1543|Homo sapiens ATP-binding cassette su... 71 2e-11
AY028900-1|AAK30025.1| 1543|Homo sapiens ATP-binding cassette A1... 71 2e-11
Y14318-1|CAA74699.1| 606|Homo sapiens peroxisomal ABC-transport... 70 4e-11
CR457104-1|CAG33385.1| 606|Homo sapiens ABCD4 protein. 70 4e-11
BT007412-1|AAP36080.1| 606|Homo sapiens ATP-binding cassette, s... 70 4e-11
BC012815-1|AAH12815.1| 606|Homo sapiens ATP-binding cassette, s... 70 4e-11
AF009746-1|AAB83967.1| 606|Homo sapiens peroxisomal membrane pr... 70 4e-11
AF328787-1|AAK00959.1| 2146|Homo sapiens ABC transporter member ... 69 7e-11
AF311102-1|AAN04657.1| 2146|Homo sapiens ABC transporter ABCA7 p... 69 7e-11
AF250238-1|AAF85794.1| 2146|Homo sapiens macrophage ABC transpor... 69 7e-11
AB055390-1|BAB62294.1| 2008|Homo sapiens ABCA-SSN protein. 69 7e-11
DQ388136-1|ABD72199.1| 1321|Homo sapiens cystic fibrosis transme... 69 1e-10
Z31348-1|CAA83230.1| 745|Homo sapiens adrenoleukodystropy protein. 68 2e-10
Z21876-1|CAA79922.1| 745|Homo sapiens ALD protein (ALDP) protein. 68 2e-10
BC025358-1|AAH25358.1| 745|Homo sapiens ATP-binding cassette, s... 68 2e-10
BC015541-1|AAH15541.1| 745|Homo sapiens ATP-binding cassette, s... 68 2e-10
M81182-1|AAA60128.1| 659|Homo sapiens 70kDa peroxisomal membran... 67 3e-10
BC068509-1|AAH68509.1| 549|Homo sapiens ABCD3 protein protein. 67 3e-10
AL138758-1|CAC15960.2| 659|Homo sapiens ATP-binding cassette, s... 67 3e-10
X58528-1|CAA41416.1| 659|Homo sapiens 70kDa peroxisomal membran... 67 4e-10
AY048757-1|AAL06598.1| 785|Homo sapiens ATP-binding cassette tr... 67 4e-10
AK128570-1|BAC87504.1| 851|Homo sapiens protein ( Homo sapiens ... 65 2e-09
AY849794-1|AAW33782.1| 159|Homo sapiens cystic fibrosis transme... 63 5e-09
AY848828-1|AAW33655.1| 159|Homo sapiens cystic fibrosis transme... 63 5e-09
AF492485-1|AAM11658.1| 45|Homo sapiens TAP1 protein. 63 5e-09
AC002457-1|AAM49149.1| 234|Homo sapiens unknown protein. 62 8e-09
BC104903-1|AAI04904.1| 740|Homo sapiens ATP-binding cassette, s... 62 1e-08
BC104901-1|AAI04902.1| 740|Homo sapiens ATP-binding cassette, s... 62 1e-08
AJ000327-1|CAA03994.1| 740|Homo sapiens adrenoleukodystrophy re... 62 1e-08
AF119831-1|AAD30439.1| 740|Homo sapiens adrenoleukodystrophy-re... 62 1e-08
AY848832-1|AAW33659.1| 418|Homo sapiens cystic fibrosis transme... 61 2e-08
AY848831-1|AAW33658.1| 405|Homo sapiens cystic fibrosis transme... 61 2e-08
AK128129-1|BAC87287.1| 467|Homo sapiens . protein. 61 3e-08
U16763-1|AAA89080.1| 44|Homo sapiens TAP1 protein. 60 6e-08
U07197-1|AAB60321.1| 45|Homo sapiens TAP1 protein. 59 1e-07
BC041091-1|AAH41091.1| 646|Homo sapiens ATP-binding cassette, s... 59 1e-07
AJ308237-1|CAC87131.1| 646|Homo sapiens ABC transporter protein. 59 1e-07
AJ300465-1|CAC17140.1| 627|Homo sapiens putative white family A... 59 1e-07
AF320293-1|AAG40003.1| 651|Homo sapiens ABCG5 protein. 58 1e-07
AF312715-1|AAG53099.1| 651|Homo sapiens sterolin protein. 58 1e-07
AC108476-1|AAY24010.1| 549|Homo sapiens unknown protein. 58 1e-07
X83467-1|CAA58470.1| 660|Homo sapiens 70kD peroxisomal integral... 58 2e-07
AK058170-1|BAB71700.1| 364|Homo sapiens protein ( Homo sapiens ... 58 2e-07
AK056533-1|BAB71208.1| 865|Homo sapiens protein ( Homo sapiens ... 58 2e-07
AB067475-1|BAB67781.1| 737|Homo sapiens KIAA1888 protein protein. 58 2e-07
BC051320-1|AAH51320.1| 419|Homo sapiens ABCA10 protein protein. 57 4e-07
AF165306-1|AAD49852.1| 849|Homo sapiens ATP cassette binding tr... 56 1e-06
BC008755-1|AAH08755.1| 867|Homo sapiens ABCA2 protein protein. 55 1e-06
M37725-1|AAA88048.1| 57|Homo sapiens PGY1 protein. 54 4e-06
DQ996467-1|ABI97388.1| 655|Homo sapiens ATP-binding cassette, s... 53 7e-06
BC092408-1|AAH92408.1| 611|Homo sapiens ABCG2 protein protein. 53 7e-06
BC021281-1|AAH21281.1| 655|Homo sapiens ATP-binding cassette, s... 53 7e-06
AY333756-1|AAQ92942.1| 655|Homo sapiens ATP-binding cassette su... 53 7e-06
AY333755-1|AAQ92941.1| 655|Homo sapiens mutant ATP-binding cass... 53 7e-06
AY017168-1|AAG52982.1| 655|Homo sapiens ABC transporter ABCG2 p... 53 7e-06
AL162060-1|CAB82398.1| 373|Homo sapiens hypothetical protein pr... 53 7e-06
AF463519-1|AAO14617.1| 655|Homo sapiens ATP-binding cassette pr... 53 7e-06
AF098951-1|AAC97367.1| 655|Homo sapiens breast cancer resistanc... 53 7e-06
AC097484-1|AAY40902.1| 607|Homo sapiens unknown protein. 53 7e-06
AB056867-1|BAB39212.1| 655|Homo sapiens Breast Cancer Resistanc... 53 7e-06
AB051855-1|BAB46933.1| 655|Homo sapiens ATP-binding cassette su... 53 7e-06
BX248518-7|CAM26017.1| 845|Homo sapiens ATP-binding cassette su... 52 9e-06
BX248518-6|CAM26016.1| 807|Homo sapiens ATP-binding cassette su... 52 9e-06
BX119957-3|CAM25907.1| 845|Homo sapiens ATP-binding cassette su... 52 9e-06
BX119957-2|CAM25906.1| 807|Homo sapiens ATP-binding cassette su... 52 9e-06
BX000357-8|CAI18563.1| 845|Homo sapiens ATP-binding cassette, s... 52 9e-06
BX000357-6|CAI18562.1| 807|Homo sapiens ATP-binding cassette, s... 52 9e-06
BC113657-1|AAI13658.1| 673|Homo sapiens ATP-binding cassette, s... 52 9e-06
BC112923-1|AAI12924.1| 845|Homo sapiens ATP-binding cassette, s... 52 9e-06
BC034488-1|AAH34488.1| 845|Homo sapiens ATP-binding cassette, s... 52 9e-06
BA000025-75|BAB63325.1| 807|Homo sapiens TNFalpha-inducible ATP... 52 9e-06
AY785909-1|AAX11382.1| 134|Homo sapiens ATP-binding cassette su... 52 9e-06
AL662825-8|CAI17836.1| 807|Homo sapiens ATP-binding cassette, s... 52 9e-06
AL662825-7|CAI17837.1| 845|Homo sapiens ATP-binding cassette, s... 52 9e-06
AL662800-8|CAI18158.1| 845|Homo sapiens ATP-binding cassette, s... 52 9e-06
AL662800-7|CAI18159.1| 807|Homo sapiens ATP-binding cassette, s... 52 9e-06
AK097296-1|BAC04994.1| 815|Homo sapiens protein ( Homo sapiens ... 52 9e-06
AF351824-1|AAK84663.1| 672|Homo sapiens sterolin-2 protein. 52 9e-06
AF324494-1|AAK84078.1| 673|Homo sapiens sterolin-2 protein. 52 9e-06
AF320294-1|AAG40004.1| 673|Homo sapiens ABCG8 protein. 52 9e-06
AF027302-1|AAC70891.1| 807|Homo sapiens TNF-alpha stimulated AB... 52 9e-06
AC108476-2|AAY24011.1| 673|Homo sapiens unknown protein. 52 9e-06
AB209564-1|BAD92801.1| 593|Homo sapiens ATP-binding cassette, s... 52 9e-06
AB202093-1|BAE78612.1| 807|Homo sapiens ATP-binding cassette, s... 52 9e-06
AB103602-1|BAF31263.1| 807|Homo sapiens ABC50 protein protein. 52 9e-06
AB088096-1|BAC54928.1| 807|Homo sapiens ATP-binding cassette, s... 52 9e-06
AY289766-1|AAP44087.1| 655|Homo sapiens ABC transporter protein. 52 1e-05
AL807752-20|CAI12766.1| 226|Homo sapiens ATP-binding cassette, ... 52 1e-05
AF103796-1|AAD09188.1| 655|Homo sapiens placenta-specific ATP-b... 52 1e-05
AK128516-1|BAC87475.1| 788|Homo sapiens protein ( Homo sapiens ... 51 3e-05
AL137481-1|CAB70762.1| 269|Homo sapiens hypothetical protein pr... 50 5e-05
D78570-1|BAA11414.1| 69|Homo sapiens TAP2 protein. 49 8e-05
S70266-1|AAD14055.1| 33|Homo sapiens TAP1 protein. 49 1e-04
AB020629-1|BAA74845.2| 1591|Homo sapiens KIAA0822 protein protein. 49 1e-04
S70274-1|AAD14056.1| 33|Homo sapiens TAP1 protein. 48 1e-04
BC051884-1|AAH51884.2| 709|Homo sapiens ATP-binding cassette, s... 48 2e-04
BC051754-1|AAH51754.1| 709|Homo sapiens ATP-binding cassette, s... 48 2e-04
BC009253-1|AAH09253.1| 709|Homo sapiens ATP-binding cassette, s... 48 2e-04
AK092415-1|BAC03881.1| 703|Homo sapiens protein ( Homo sapiens ... 48 2e-04
AK024758-1|BAB14989.1| 390|Homo sapiens protein ( Homo sapiens ... 48 2e-04
AK002060-1|BAA92063.1| 709|Homo sapiens protein ( Homo sapiens ... 48 2e-04
AJ278917-1|CAC07210.1| 109|Homo sapiens putative ATP-binding ca... 47 4e-04
BX248518-8|CAM26018.1| 238|Homo sapiens ATP-binding cassette su... 46 6e-04
BX119957-4|CAM25908.1| 238|Homo sapiens ATP-binding cassette su... 46 6e-04
BX000357-7|CAM25770.1| 238|Homo sapiens ATP-binding cassette, s... 46 6e-04
AL662825-6|CAM25037.1| 238|Homo sapiens ATP-binding cassette, s... 46 6e-04
AL662800-6|CAI18157.2| 238|Homo sapiens ATP-binding cassette, s... 46 6e-04
S70256-1|AAD14054.1| 33|Homo sapiens TAP1 protein. 46 8e-04
U18236-1|AAA84437.2| 131|Homo sapiens ATP-binding cassette prot... 46 0.001
AK091270-1|BAC03623.1| 293|Homo sapiens protein ( Homo sapiens ... 45 0.001
AY288307-1|AAP31310.1| 541|Homo sapiens ATP-binding cassette su... 44 0.002
DQ148409-1|AAZ38723.1| 599|Homo sapiens ATP-binding cassette, s... 44 0.004
BT009779-1|AAP88781.1| 599|Homo sapiens ATP-binding cassette, s... 44 0.004
BC016283-1|AAH16283.1| 599|Homo sapiens ATP-binding cassette, s... 44 0.004
AF356348-1|AAL35305.1| 103|Homo sapiens breast cancer resistanc... 44 0.004
AB062293-1|BAB93476.1| 599|Homo sapiens ATP-binding cassette su... 44 0.004
BT007451-1|AAP36119.1| 623|Homo sapiens ATP-binding cassette, s... 43 0.006
BC001661-1|AAH01661.1| 623|Homo sapiens ATP-binding cassette, s... 43 0.006
AJ575045-1|CAE00759.1| 58|Homo sapiens cystic fibrosis transme... 43 0.006
AJ575044-1|CAE00758.1| 58|Homo sapiens cystic fibrosis transme... 43 0.006
AJ575043-1|CAE00757.1| 58|Homo sapiens cystic fibrosis transme... 43 0.006
AJ575042-1|CAE00756.1| 58|Homo sapiens cystic fibrosis transme... 43 0.006
AJ575041-1|CAE00755.2| 58|Homo sapiens cystic fibrosis transme... 43 0.006
AJ005016-1|CAA06290.1| 550|Homo sapiens ABC transporter protein. 43 0.006
AF261092-1|AAG13903.1| 623|Homo sapiens iron inhibited ABC tran... 43 0.006
AF261091-1|AAG13902.1| 623|Homo sapiens iron inhibited ABC tran... 43 0.006
AC021097-3|AAS00379.1| 623|Homo sapiens unknown protein. 43 0.006
AC021097-2|AAS00378.1| 634|Homo sapiens unknown protein. 43 0.006
AJ575033-1|CAE00747.1| 52|Homo sapiens cystic fibrosis transme... 43 0.007
AJ575032-1|CAE00746.1| 52|Homo sapiens cystic fibrosis transme... 43 0.007
AJ575031-1|CAE00745.1| 52|Homo sapiens cystic fibrosis transme... 43 0.007
AJ575030-1|CAE00744.1| 52|Homo sapiens cystic fibrosis transme... 43 0.007
AJ575029-1|CAE00743.1| 52|Homo sapiens cystic fibrosis transme... 43 0.007
AJ575028-1|CAE00742.1| 52|Homo sapiens cystic fibrosis transme... 43 0.007
BC016988-1|AAH16988.1| 345|Homo sapiens Unknown (protein for IM... 41 0.022
AK002040-1|BAA92050.1| 456|Homo sapiens protein ( Homo sapiens ... 41 0.029
X76388-1|CAA53972.1| 599|Homo sapiens RNase L inhibitor protein. 37 0.36
X74987-1|CAA52920.1| 402|Homo sapiens endoribonuclease protein. 37 0.36
BC020618-1|AAH20618.1| 179|Homo sapiens ABCB4 protein protein. 36 0.63
AL080207-1|CAB45776.1| 196|Homo sapiens hypothetical protein pr... 35 1.5
AY421738-1|AAR07958.1| 240|Homo sapiens mutant adrenoleukodystr... 34 2.6
AF016534-1|AAB70218.1| 37|Homo sapiens P-glycoprotein protein. 34 2.6
AY421737-1|AAR07957.1| 240|Homo sapiens mutant adrenoleukodystr... 34 3.4
AY007425-1|AAG12163.1| 109|Homo sapiens TAP2 protein protein. 34 3.4
Z75889-1|CAI10806.2| 1447|Homo sapiens androgen-induced prolifer... 33 5.9
AL353692-3|CAI16236.1| 5596|Homo sapiens MDN1, midasin homolog (... 33 5.9
AL158813-2|CAI13203.1| 5596|Homo sapiens MDN1, midasin homolog (... 33 5.9
AL138820-1|CAH73160.2| 1447|Homo sapiens androgen-induced prolif... 33 5.9
AL137201-1|CAB69911.1| 1447|Homo sapiens hypothetical protein pr... 33 5.9
AL096678-1|CAI42279.1| 5596|Homo sapiens MDN1, midasin homolog (... 33 5.9
AF503925-1|AAM77722.1| 5596|Homo sapiens midasin protein. 33 5.9
AB023196-1|BAA76823.2| 1483|Homo sapiens KIAA0979 protein protein. 33 5.9
>M29447-1|AAA59576.1| 1280|Homo sapiens P glycoprotein protein.
Length = 1280
Score = 781 bits (1931), Expect = 0.0
Identities = 448/1160 (38%), Positives = 660/1160 (56%), Gaps = 57/1160 (4%)
Query: 28 LSVALVSWSALKQITTIRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKL 87
+ V+ +A +QI IRK F A++RQ++ WFD L +++++++ K+ EG+G+K+
Sbjct: 131 IQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKI 190
Query: 88 AVVSNLVGTSIICLCTAFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQA 147
+ + T F GWKL L + + P +++ + + +E+ +Y++A
Sbjct: 191 GMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKA 250
Query: 148 GKQAEEVLKSVKTVVAFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLN 207
G AEEVL +++TV+AFGG+ E++RY LE A+ G ++ + + G ++L Y+
Sbjct: 251 GAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASY 310
Query: 208 TIGFMYGTRLIIEDANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAA 267
+ F YGT L++ Y IG VL++ FSV + S+ P +E FA ARGAA
Sbjct: 311 ALAFWYGTTLVLSGE--------YSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAA 362
Query: 268 ASIFSLLDKHPKIDCLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGES 327
IF ++D P ID S++G P + G + +VHFSYPSR ++KILKG +L ++ G++
Sbjct: 363 YEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQT 422
Query: 328 VALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRG 387
VALVG+SGCGKST +QL+QRLYDP +G V +DG++++T+N+ +LR +GVV QEPVLF
Sbjct: 423 VALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFAT 482
Query: 388 TIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIA 447
TI +NI G T +++ + + A A++FI LP+ ++T++GERGA LSGGQKQRIAIA
Sbjct: 483 TIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIA 542
Query: 448 RSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMD 507
R+L+R P +LLLDEATSALD SE VQ ALD+A GRTT+ ++HRLST+ N I D
Sbjct: 543 RALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFD 602
Query: 508 QGTIIEQGTHVELMKAKGFYHKLVT---SGKETK---EPEEIGTVLEEQETKQNGELQPA 561
G I+E+G H ELMK KG Y KLVT +G E + +E + ++ E N
Sbjct: 603 DGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDALEMSSNDSRSSL 662
Query: 562 VRPEPDVKRRSVRKLH---RRQSAKGAHEWMATPRGSISSIMSTALQSHAY--------- 609
+R RRSVR R+ S K A + + P S IM L Y
Sbjct: 663 IRKRST--RRSVRGSQAQDRKLSTKEALD-ESIPPVSFWRIMKLNLTEWPYFVVGVFCAI 719
Query: 610 -----SDTYXXXXXXXXXXXTPVSDWQLLKLNTPEW--LYLTVGSIAA---FIQGACF-- 657
+ T + D + + N+ + L+L +G I+ F+QG F
Sbjct: 720 INGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGK 779
Query: 658 --PVFALLLGYT------SGEIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQG 709
+ L Y ++ +FD NT GA+ RL+ D A+V+GA G R+ +I Q
Sbjct: 780 AGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQN 839
Query: 710 FSSVTVGFIMAMSYNWKLTLVSTTFLPLM-VGSIWLEGIMSQKSQQDEREAMESATAIAT 768
+++ G I++ Y W+LTL+ +P++ + + ++S ++ +D++E +E A IAT
Sbjct: 840 IANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKE-LEGAGKIAT 898
Query: 769 EAVVSIKTVQSLGIESLFITRFQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVI 828
EA+ + +TV SL E F + +L ++K+ G+ + SY
Sbjct: 899 EAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFR 958
Query: 829 YGAVLVAHGXXXXXXXXXXXXXXMYGAYMLGQSLVYAPSFNSAKTCGARILSIINREPRI 888
+GA LVAH ++GA +GQ +AP + AK A I+ II + P I
Sbjct: 959 FGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLI 1018
Query: 889 RT--VDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCG 946
+ +GL + GN + +V F+YPTR +L+G+ L V+ G+T+ALVGSSGCG
Sbjct: 1019 DSYSTEGLMPN---TLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCG 1075
Query: 947 KSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYG 1006
KSTV+QL++RFYDP G + LDG +I K L + LR LG+V QEPILFD ++AENIAYG
Sbjct: 1076 KSTVVQLLERFYDPLAGKVLLDGKEI-KRLNVQWLRAHLGIVSQEPILFDCSIAENIAYG 1134
Query: 1007 DNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSP 1066
DNSR + +E H FI SLP Y T KQR+ IARAL+R P
Sbjct: 1135 DNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQP 1194
Query: 1067 RLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEK 1126
+LLLDEATSALD SE+ V EALD A +GRTCI IAHRL+TI++AD+I V G++ E
Sbjct: 1195 HILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEH 1254
Query: 1127 GNHAELIGLKGHYWQLSKQQ 1146
G H +L+ KG Y+ + Q
Sbjct: 1255 GTHQQLLAQKGIYFSMVSVQ 1274
Score = 349 bits (857), Expect = 5e-95
Identities = 187/499 (37%), Positives = 291/499 (58%), Gaps = 12/499 (2%)
Query: 44 IRKLFLTAVLRQDMTWFDTDSDFN--LASKMSENLMKLKEGMGEKLAVVSNLVGTSIICL 101
+R + ++LRQD++WFD + L ++++ + ++K +G +LAV++ + +
Sbjct: 788 LRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGI 847
Query: 102 CTAFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTV 161
+F GW+L L + ++P +A V + ++++ + AGK A E +++ +TV
Sbjct: 848 IISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTV 907
Query: 162 VAFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIED 221
V+ E Y L+ + R+ G+ F + Y F +G L+
Sbjct: 908 VSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHK 967
Query: 222 ANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKID 281
+D ++ + ++ F MA ++ P +A A+ +AA I +++K P ID
Sbjct: 968 LMSFED----VLLVFSAVVFGA-MAVGQVSSFAPD---YAKAKISAAHIIMIIEKTPLID 1019
Query: 282 CLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
S G P + G ++ +V F+YP+R DI +L+G SL +K G+++ALVGSSGCGKST+
Sbjct: 1020 SYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTV 1079
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPE-- 399
+QLL+R YDP G V LDG+ +K LN+ WLR+ LG+V QEP+LF +I +NIA G
Sbjct: 1080 VQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRV 1139
Query: 400 ATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLL 459
+ E++ R A+ A H FI++LPN Y T +G++G LSGGQKQRIAIAR+L+R+P +LLL
Sbjct: 1140 VSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLL 1199
Query: 460 DEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVE 519
DEATSALD SEK VQ ALD+A GRT + ++HRLSTI N I+ G + E GTH +
Sbjct: 1200 DEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQ 1259
Query: 520 LMKAKGFYHKLVTSGKETK 538
L+ KG Y +V+ TK
Sbjct: 1260 LLAQKGIYFSMVSVQAGTK 1278
>AY910577-1|AAW82430.1| 1280|Homo sapiens ATP-binding cassette,
sub-family B (MDR/TAP), member 1 protein.
Length = 1280
Score = 781 bits (1931), Expect = 0.0
Identities = 448/1160 (38%), Positives = 660/1160 (56%), Gaps = 57/1160 (4%)
Query: 28 LSVALVSWSALKQITTIRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKL 87
+ V+ +A +QI IRK F A++RQ++ WFD L +++++++ K+ EG+G+K+
Sbjct: 131 IQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKI 190
Query: 88 AVVSNLVGTSIICLCTAFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQA 147
+ + T F GWKL L + + P +++ + + +E+ +Y++A
Sbjct: 191 GMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKA 250
Query: 148 GKQAEEVLKSVKTVVAFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLN 207
G AEEVL +++TV+AFGG+ E++RY LE A+ G ++ + + G ++L Y+
Sbjct: 251 GAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASY 310
Query: 208 TIGFMYGTRLIIEDANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAA 267
+ F YGT L++ Y IG VL++ FSV + S+ P +E FA ARGAA
Sbjct: 311 ALAFWYGTTLVLSGE--------YSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAA 362
Query: 268 ASIFSLLDKHPKIDCLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGES 327
IF ++D P ID S++G P + G + +VHFSYPSR ++KILKG +L ++ G++
Sbjct: 363 YEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQT 422
Query: 328 VALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRG 387
VALVG+SGCGKST +QL+QRLYDP +G V +DG++++T+N+ +LR +GVV QEPVLF
Sbjct: 423 VALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFAT 482
Query: 388 TIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIA 447
TI +NI G T +++ + + A A++FI LP+ ++T++GERGA LSGGQKQRIAIA
Sbjct: 483 TIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIA 542
Query: 448 RSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMD 507
R+L+R P +LLLDEATSALD SE VQ ALD+A GRTT+ ++HRLST+ N I D
Sbjct: 543 RALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFD 602
Query: 508 QGTIIEQGTHVELMKAKGFYHKLVT---SGKETK---EPEEIGTVLEEQETKQNGELQPA 561
G I+E+G H ELMK KG Y KLVT +G E + +E + ++ E N
Sbjct: 603 DGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDALEMSSNDSRSSL 662
Query: 562 VRPEPDVKRRSVRKLH---RRQSAKGAHEWMATPRGSISSIMSTALQSHAY--------- 609
+R RRSVR R+ S K A + + P S IM L Y
Sbjct: 663 IRKRST--RRSVRGSQAQDRKLSTKEALD-ESIPPVSFWRIMKLNLTEWPYFVVGVFCAI 719
Query: 610 -----SDTYXXXXXXXXXXXTPVSDWQLLKLNTPEW--LYLTVGSIAA---FIQGACF-- 657
+ T + D + + N+ + L+L +G I+ F+QG F
Sbjct: 720 INGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGK 779
Query: 658 --PVFALLLGYT------SGEIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQG 709
+ L Y ++ +FD NT GA+ RL+ D A+V+GA G R+ +I Q
Sbjct: 780 AGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQN 839
Query: 710 FSSVTVGFIMAMSYNWKLTLVSTTFLPLM-VGSIWLEGIMSQKSQQDEREAMESATAIAT 768
+++ G I++ Y W+LTL+ +P++ + + ++S ++ +D++E +E A IAT
Sbjct: 840 IANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKE-LEGAGKIAT 898
Query: 769 EAVVSIKTVQSLGIESLFITRFQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVI 828
EA+ + +TV SL E F + +L ++K+ G+ + SY
Sbjct: 899 EAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFR 958
Query: 829 YGAVLVAHGXXXXXXXXXXXXXXMYGAYMLGQSLVYAPSFNSAKTCGARILSIINREPRI 888
+GA LVAH ++GA +GQ +AP + AK A I+ II + P I
Sbjct: 959 FGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLI 1018
Query: 889 RT--VDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCG 946
+ +GL + GN + +V F+YPTR +L+G+ L V+ G+T+ALVGSSGCG
Sbjct: 1019 DSYSTEGLMPN---TLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCG 1075
Query: 947 KSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYG 1006
KSTV+QL++RFYDP G + LDG +I K L + LR LG+V QEPILFD ++AENIAYG
Sbjct: 1076 KSTVVQLLERFYDPLAGKVLLDGKEI-KRLNVQWLRAHLGIVSQEPILFDCSIAENIAYG 1134
Query: 1007 DNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSP 1066
DNSR + +E H FI SLP Y T KQR+ IARAL+R P
Sbjct: 1135 DNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQP 1194
Query: 1067 RLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEK 1126
+LLLDEATSALD SE+ V EALD A +GRTCI IAHRL+TI++AD+I V G++ E
Sbjct: 1195 HILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEH 1254
Query: 1127 GNHAELIGLKGHYWQLSKQQ 1146
G H +L+ KG Y+ + Q
Sbjct: 1255 GTHQQLLAQKGIYFSMVSVQ 1274
Score = 349 bits (857), Expect = 5e-95
Identities = 187/499 (37%), Positives = 291/499 (58%), Gaps = 12/499 (2%)
Query: 44 IRKLFLTAVLRQDMTWFDTDSDFN--LASKMSENLMKLKEGMGEKLAVVSNLVGTSIICL 101
+R + ++LRQD++WFD + L ++++ + ++K +G +LAV++ + +
Sbjct: 788 LRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGI 847
Query: 102 CTAFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTV 161
+F GW+L L + ++P +A V + ++++ + AGK A E +++ +TV
Sbjct: 848 IISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTV 907
Query: 162 VAFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIED 221
V+ E Y L+ + R+ G+ F + Y F +G L+
Sbjct: 908 VSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHK 967
Query: 222 ANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKID 281
+D ++ + ++ F MA ++ P +A A+ +AA I +++K P ID
Sbjct: 968 LMSFED----VLLVFSAVVFGA-MAVGQVSSFAPD---YAKAKISAAHIIMIIEKTPLID 1019
Query: 282 CLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
S G P + G ++ +V F+YP+R DI +L+G SL +K G+++ALVGSSGCGKST+
Sbjct: 1020 SYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTV 1079
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPE-- 399
+QLL+R YDP G V LDG+ +K LN+ WLR+ LG+V QEP+LF +I +NIA G
Sbjct: 1080 VQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRV 1139
Query: 400 ATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLL 459
+ E++ R A+ A H FI++LPN Y T +G++G LSGGQKQRIAIAR+L+R+P +LLL
Sbjct: 1140 VSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLL 1199
Query: 460 DEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVE 519
DEATSALD SEK VQ ALD+A GRT + ++HRLSTI N I+ G + E GTH +
Sbjct: 1200 DEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQ 1259
Query: 520 LMKAKGFYHKLVTSGKETK 538
L+ KG Y +V+ TK
Sbjct: 1260 LLAQKGIYFSMVSVQAGTK 1278
>BC130424-1|AAI30425.1| 1280|Homo sapiens ATP-binding cassette,
sub-family B (MDR/TAP), member 1 protein.
Length = 1280
Score = 780 bits (1928), Expect = 0.0
Identities = 447/1160 (38%), Positives = 660/1160 (56%), Gaps = 57/1160 (4%)
Query: 28 LSVALVSWSALKQITTIRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKL 87
+ V+ +A +QI IRK F A++RQ++ WFD L +++++++ K+ EG+G+K+
Sbjct: 131 IQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKI 190
Query: 88 AVVSNLVGTSIICLCTAFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQA 147
+ + T F GWKL L + + P +++ + + +E+ +Y++A
Sbjct: 191 GMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKA 250
Query: 148 GKQAEEVLKSVKTVVAFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLN 207
G AEEVL +++TV+AFGG+ E++RY LE A+ G ++ + + G ++L Y+
Sbjct: 251 GAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASY 310
Query: 208 TIGFMYGTRLIIEDANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAA 267
+ F YGT L++ Y IG VL++ FSV + S+ P +E FA ARGAA
Sbjct: 311 ALAFWYGTTLVLSGE--------YSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAA 362
Query: 268 ASIFSLLDKHPKIDCLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGES 327
IF ++D P ID S++G P + G + +VHF+YPSR ++KILKG +L ++ G++
Sbjct: 363 YEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFNYPSRKEVKILKGLNLKVQSGQT 422
Query: 328 VALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRG 387
VALVG+SGCGKST +QL+QRLYDP +G V +DG++++T+N+ +LR +GVV QEPVLF
Sbjct: 423 VALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFAT 482
Query: 388 TIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIA 447
TI +NI G T +++ + + A A++FI LP+ ++T++GERGA LSGGQKQRIAIA
Sbjct: 483 TIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIA 542
Query: 448 RSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMD 507
R+L+R P +LLLDEATSALD SE VQ ALD+A GRTT+ ++HRLST+ N I D
Sbjct: 543 RALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFD 602
Query: 508 QGTIIEQGTHVELMKAKGFYHKLVT---SGKETK---EPEEIGTVLEEQETKQNGELQPA 561
G I+E+G H ELMK KG Y KLVT +G E + +E + ++ E N
Sbjct: 603 DGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDALEMSSNDSRSSL 662
Query: 562 VRPEPDVKRRSVRKLH---RRQSAKGAHEWMATPRGSISSIMSTALQSHAY--------- 609
+R RRSVR R+ S K A + + P S IM L Y
Sbjct: 663 IRKRST--RRSVRGSQAQDRKLSTKEALD-ESIPPVSFWRIMKLNLTEWPYFVVGVFCAI 719
Query: 610 -----SDTYXXXXXXXXXXXTPVSDWQLLKLNTPEW--LYLTVGSIAA---FIQGACF-- 657
+ T + D + + N+ + L+L +G I+ F+QG F
Sbjct: 720 INGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGK 779
Query: 658 --PVFALLLGYT------SGEIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQG 709
+ L Y ++ +FD NT GA+ RL+ D A+V+GA G R+ +I Q
Sbjct: 780 AGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQN 839
Query: 710 FSSVTVGFIMAMSYNWKLTLVSTTFLPLM-VGSIWLEGIMSQKSQQDEREAMESATAIAT 768
+++ G I++ Y W+LTL+ +P++ + + ++S ++ +D++E +E A IAT
Sbjct: 840 IANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKE-LEGAGKIAT 898
Query: 769 EAVVSIKTVQSLGIESLFITRFQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVI 828
EA+ + +TV SL E F + +L ++K+ G+ + SY
Sbjct: 899 EAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFR 958
Query: 829 YGAVLVAHGXXXXXXXXXXXXXXMYGAYMLGQSLVYAPSFNSAKTCGARILSIINREPRI 888
+GA LVAH ++GA +GQ +AP + AK A I+ II + P I
Sbjct: 959 FGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLI 1018
Query: 889 RT--VDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCG 946
+ +GL + GN + +V F+YPTR +L+G+ L V+ G+T+ALVGSSGCG
Sbjct: 1019 DSYSTEGLMPN---TLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCG 1075
Query: 947 KSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYG 1006
KSTV+QL++RFYDP G + LDG +I K L + LR LG+V QEPILFD ++AENIAYG
Sbjct: 1076 KSTVVQLLERFYDPLAGKVLLDGKEI-KRLNVQWLRAHLGIVSQEPILFDCSIAENIAYG 1134
Query: 1007 DNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSP 1066
DNSR + +E H FI SLP Y T KQR+ IARAL+R P
Sbjct: 1135 DNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQP 1194
Query: 1067 RLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEK 1126
+LLLDEATSALD SE+ V EALD A +GRTCI IAHRL+TI++AD+I V G++ E
Sbjct: 1195 HILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEH 1254
Query: 1127 GNHAELIGLKGHYWQLSKQQ 1146
G H +L+ KG Y+ + Q
Sbjct: 1255 GTHQQLLAQKGIYFSMVSVQ 1274
Score = 349 bits (857), Expect = 5e-95
Identities = 187/499 (37%), Positives = 291/499 (58%), Gaps = 12/499 (2%)
Query: 44 IRKLFLTAVLRQDMTWFDTDSDFN--LASKMSENLMKLKEGMGEKLAVVSNLVGTSIICL 101
+R + ++LRQD++WFD + L ++++ + ++K +G +LAV++ + +
Sbjct: 788 LRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGI 847
Query: 102 CTAFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTV 161
+F GW+L L + ++P +A V + ++++ + AGK A E +++ +TV
Sbjct: 848 IISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTV 907
Query: 162 VAFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIED 221
V+ E Y L+ + R+ G+ F + Y F +G L+
Sbjct: 908 VSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHK 967
Query: 222 ANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKID 281
+D ++ + ++ F MA ++ P +A A+ +AA I +++K P ID
Sbjct: 968 LMSFED----VLLVFSAVVFGA-MAVGQVSSFAPD---YAKAKISAAHIIMIIEKTPLID 1019
Query: 282 CLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
S G P + G ++ +V F+YP+R DI +L+G SL +K G+++ALVGSSGCGKST+
Sbjct: 1020 SYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTV 1079
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPE-- 399
+QLL+R YDP G V LDG+ +K LN+ WLR+ LG+V QEP+LF +I +NIA G
Sbjct: 1080 VQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRV 1139
Query: 400 ATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLL 459
+ E++ R A+ A H FI++LPN Y T +G++G LSGGQKQRIAIAR+L+R+P +LLL
Sbjct: 1140 VSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLL 1199
Query: 460 DEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVE 519
DEATSALD SEK VQ ALD+A GRT + ++HRLSTI N I+ G + E GTH +
Sbjct: 1200 DEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQ 1259
Query: 520 LMKAKGFYHKLVTSGKETK 538
L+ KG Y +V+ TK
Sbjct: 1260 LLAQKGIYFSMVSVQAGTK 1278
>M14758-1|AAA59575.1| 1280|Homo sapiens PGY1 protein.
Length = 1280
Score = 777 bits (1922), Expect = 0.0
Identities = 447/1160 (38%), Positives = 659/1160 (56%), Gaps = 57/1160 (4%)
Query: 28 LSVALVSWSALKQITTIRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKL 87
+ V+ +A +QI IRK F A++RQ++ WFD L +++++++ K+ E +G+K+
Sbjct: 131 IQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEVIGDKI 190
Query: 88 AVVSNLVGTSIICLCTAFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQA 147
+ + T F GWKL L + + P +++ + + +E+ +Y++A
Sbjct: 191 GMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKA 250
Query: 148 GKQAEEVLKSVKTVVAFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLN 207
G AEEVL +++TV+AFGG+ E++RY LE A+ G ++ + + G ++L Y+
Sbjct: 251 GAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASY 310
Query: 208 TIGFMYGTRLIIEDANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAA 267
+ F YGT L++ Y IG VL++ FSV + S+ P +E FA ARGAA
Sbjct: 311 ALAFWYGTTLVLSGE--------YSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAA 362
Query: 268 ASIFSLLDKHPKIDCLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGES 327
IF ++D P ID S++G P + G + +VHFSYPSR ++KILKG +L ++ G++
Sbjct: 363 YEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQT 422
Query: 328 VALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRG 387
VALVG+SGCGKST +QL+QRLYDP +G V +DG++++T+N+ +LR +GVV QEPVLF
Sbjct: 423 VALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFAT 482
Query: 388 TIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIA 447
TI +NI G T +++ + + A A++FI LP+ ++T++GERGA LSGGQKQRIAIA
Sbjct: 483 TIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIA 542
Query: 448 RSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMD 507
R+L+R P +LLLDEATSALD SE VQ ALD+A GRTT+ ++HRLST+ N I D
Sbjct: 543 RALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFD 602
Query: 508 QGTIIEQGTHVELMKAKGFYHKLVT---SGKETK---EPEEIGTVLEEQETKQNGELQPA 561
G I+E+G H ELMK KG Y KLVT +G E + +E + ++ E N
Sbjct: 603 DGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDALEMSSNDSRSSL 662
Query: 562 VRPEPDVKRRSVRKLH---RRQSAKGAHEWMATPRGSISSIMSTALQSHAY--------- 609
+R RRSVR R+ S K A + + P S IM L Y
Sbjct: 663 IRKRST--RRSVRGSQAQDRKLSTKEALD-ESIPPVSFWRIMKLNLTEWPYFVVGVFCAI 719
Query: 610 -----SDTYXXXXXXXXXXXTPVSDWQLLKLNTPEW--LYLTVGSIAA---FIQGACF-- 657
+ T + D + + N+ + L+L +G I+ F+QG F
Sbjct: 720 INGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGK 779
Query: 658 --PVFALLLGYT------SGEIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQG 709
+ L Y ++ +FD NT GA+ RL+ D A+V+GA G R+ +I Q
Sbjct: 780 AGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQN 839
Query: 710 FSSVTVGFIMAMSYNWKLTLVSTTFLPLM-VGSIWLEGIMSQKSQQDEREAMESATAIAT 768
+++ G I++ Y W+LTL+ +P++ + + ++S ++ +D++E +E A IAT
Sbjct: 840 IANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKE-LEGAGKIAT 898
Query: 769 EAVVSIKTVQSLGIESLFITRFQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVI 828
EA+ + +TV SL E F + +L ++K+ G+ + SY
Sbjct: 899 EAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFR 958
Query: 829 YGAVLVAHGXXXXXXXXXXXXXXMYGAYMLGQSLVYAPSFNSAKTCGARILSIINREPRI 888
+GA LVAH ++GA +GQ +AP + AK A I+ II + P I
Sbjct: 959 FGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLI 1018
Query: 889 RT--VDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCG 946
+ +GL + GN + +V F+YPTR +L+G+ L V+ G+T+ALVGSSGCG
Sbjct: 1019 DSYSTEGLMPN---TLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCG 1075
Query: 947 KSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYG 1006
KSTV+QL++RFYDP G + LDG +I K L + LR LG+V QEPILFD ++AENIAYG
Sbjct: 1076 KSTVVQLLERFYDPLAGKVLLDGKEI-KRLNVQWLRAHLGIVSQEPILFDCSIAENIAYG 1134
Query: 1007 DNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSP 1066
DNSR + +E H FI SLP Y T KQR+ IARAL+R P
Sbjct: 1135 DNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQP 1194
Query: 1067 RLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEK 1126
+LLLDEATSALD SE+ V EALD A +GRTCI IAHRL+TI++AD+I V G++ E
Sbjct: 1195 HILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEH 1254
Query: 1127 GNHAELIGLKGHYWQLSKQQ 1146
G H +L+ KG Y+ + Q
Sbjct: 1255 GTHQQLLAQKGIYFSMVSVQ 1274
Score = 349 bits (857), Expect = 5e-95
Identities = 187/499 (37%), Positives = 291/499 (58%), Gaps = 12/499 (2%)
Query: 44 IRKLFLTAVLRQDMTWFDTDSDFN--LASKMSENLMKLKEGMGEKLAVVSNLVGTSIICL 101
+R + ++LRQD++WFD + L ++++ + ++K +G +LAV++ + +
Sbjct: 788 LRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGI 847
Query: 102 CTAFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTV 161
+F GW+L L + ++P +A V + ++++ + AGK A E +++ +TV
Sbjct: 848 IISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTV 907
Query: 162 VAFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIED 221
V+ E Y L+ + R+ G+ F + Y F +G L+
Sbjct: 908 VSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHK 967
Query: 222 ANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKID 281
+D ++ + ++ F MA ++ P +A A+ +AA I +++K P ID
Sbjct: 968 LMSFED----VLLVFSAVVFGA-MAVGQVSSFAPD---YAKAKISAAHIIMIIEKTPLID 1019
Query: 282 CLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
S G P + G ++ +V F+YP+R DI +L+G SL +K G+++ALVGSSGCGKST+
Sbjct: 1020 SYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTV 1079
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPE-- 399
+QLL+R YDP G V LDG+ +K LN+ WLR+ LG+V QEP+LF +I +NIA G
Sbjct: 1080 VQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRV 1139
Query: 400 ATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLL 459
+ E++ R A+ A H FI++LPN Y T +G++G LSGGQKQRIAIAR+L+R+P +LLL
Sbjct: 1140 VSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLL 1199
Query: 460 DEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVE 519
DEATSALD SEK VQ ALD+A GRT + ++HRLSTI N I+ G + E GTH +
Sbjct: 1200 DEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQ 1259
Query: 520 LMKAKGFYHKLVTSGKETK 538
L+ KG Y +V+ TK
Sbjct: 1260 LLAQKGIYFSMVSVQAGTK 1278
>AF016535-1|AAB69423.1| 1279|Homo sapiens P-glycoprotein protein.
Length = 1279
Score = 777 bits (1922), Expect = 0.0
Identities = 448/1160 (38%), Positives = 660/1160 (56%), Gaps = 58/1160 (5%)
Query: 28 LSVALVSWSALKQITTIRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKL 87
+ V+ +A +QI IRK F A++RQ++ WFD L +++++++ K+ EG+G+K+
Sbjct: 131 IQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKI 190
Query: 88 AVVSNLVGTSIICLCTAFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQA 147
+ + T F GWKL L + + P +++ + + +E+ +Y++A
Sbjct: 191 GMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKA 250
Query: 148 GKQAEEVLKSVKTVVAFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLN 207
G AEEVL +++TV+AFGG+ E++RY LE A+ G ++ + + G ++L Y+
Sbjct: 251 GAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASY 310
Query: 208 TIGFMYGTRLIIEDANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAA 267
+ F YGT L++ Y IG VL++ FSV + S+ P +E FA ARGAA
Sbjct: 311 ALAFWYGTTLVLSGE--------YSIGQVLTV-FSVLIGAFSVGQASPSIEAFANARGAA 361
Query: 268 ASIFSLLDKHPKIDCLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGES 327
IF ++D P ID S++G P + G + +VHFSYPSR ++KILKG +L ++ G++
Sbjct: 362 YEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQT 421
Query: 328 VALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRG 387
VALVG+SGCGKST +QL+QRLYDP +G V +DG++++T+N+ +LR +GVV QEPVLF
Sbjct: 422 VALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFAT 481
Query: 388 TIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIA 447
TI +NI G T +++ + + A A++FI LP+ ++T++GERGA LSGGQKQRIAIA
Sbjct: 482 TIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIA 541
Query: 448 RSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMD 507
R+L+R P +LLLDEATSALD SE VQ ALD+A GRTT+ ++HRLST+ N I D
Sbjct: 542 RALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFD 601
Query: 508 QGTIIEQGTHVELMKAKGFYHKLVT---SGKETK---EPEEIGTVLEEQETKQNGELQPA 561
G I+E+G H ELMK KG Y KLVT +G E + +E + ++ E N
Sbjct: 602 DGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDALEMSSNDSRSSL 661
Query: 562 VRPEPDVKRRSVRKLH---RRQSAKGAHEWMATPRGSISSIMSTALQSHAY--------- 609
+R RRSVR R+ S K A + + P S IM L Y
Sbjct: 662 IRKRST--RRSVRGSQAQDRKLSTKEALD-ESIPPVSFWRIMKLNLTEWPYFVVGVFCAI 718
Query: 610 -----SDTYXXXXXXXXXXXTPVSDWQLLKLNTPEW--LYLTVGSIAA---FIQGACF-- 657
+ T + D + + N+ + L+L +G I+ F+QG F
Sbjct: 719 INGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGK 778
Query: 658 --PVFALLLGYT------SGEIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQG 709
+ L Y ++ +FD NT GA+ RL+ D A+V+GA G R+ +I Q
Sbjct: 779 AGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQN 838
Query: 710 FSSVTVGFIMAMSYNWKLTLVSTTFLPLM-VGSIWLEGIMSQKSQQDEREAMESATAIAT 768
+++ G I++ Y W+LTL+ +P++ + + ++S ++ +D++E +E A IAT
Sbjct: 839 IANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKE-LEGAGKIAT 897
Query: 769 EAVVSIKTVQSLGIESLFITRFQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVI 828
EA+ + +TV SL E F + +L ++K+ G+ + SY
Sbjct: 898 EAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFR 957
Query: 829 YGAVLVAHGXXXXXXXXXXXXXXMYGAYMLGQSLVYAPSFNSAKTCGARILSIINREPRI 888
+GA LVAH ++GA +GQ +AP + AK A I+ II + P I
Sbjct: 958 FGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLI 1017
Query: 889 RT--VDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCG 946
+ +GL + GN + +V F+YPTR +L+G+ L V+ G+T+ALVGSSGCG
Sbjct: 1018 DSYSTEGLMPN---TLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCG 1074
Query: 947 KSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYG 1006
KSTV+QL++RFYDP G + LDG +I K L + LR LG+V QEPILFD ++AENIAYG
Sbjct: 1075 KSTVVQLLERFYDPLAGKVLLDGKEI-KRLNVQWLRAHLGIVSQEPILFDCSIAENIAYG 1133
Query: 1007 DNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSP 1066
DNSR + +E H FI SLP Y T KQR+ IARAL+R P
Sbjct: 1134 DNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQP 1193
Query: 1067 RLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEK 1126
+LLLDEATSALD SE+ V EALD A +GRTCI IAHRL+TI++AD+I V G++ E
Sbjct: 1194 HILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEH 1253
Query: 1127 GNHAELIGLKGHYWQLSKQQ 1146
G H +L+ KG Y+ + Q
Sbjct: 1254 GTHQQLLAQKGIYFSMVSVQ 1273
Score = 349 bits (857), Expect = 5e-95
Identities = 187/499 (37%), Positives = 291/499 (58%), Gaps = 12/499 (2%)
Query: 44 IRKLFLTAVLRQDMTWFDTDSDFN--LASKMSENLMKLKEGMGEKLAVVSNLVGTSIICL 101
+R + ++LRQD++WFD + L ++++ + ++K +G +LAV++ + +
Sbjct: 787 LRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGI 846
Query: 102 CTAFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTV 161
+F GW+L L + ++P +A V + ++++ + AGK A E +++ +TV
Sbjct: 847 IISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTV 906
Query: 162 VAFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIED 221
V+ E Y L+ + R+ G+ F + Y F +G L+
Sbjct: 907 VSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHK 966
Query: 222 ANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKID 281
+D ++ + ++ F MA ++ P +A A+ +AA I +++K P ID
Sbjct: 967 LMSFED----VLLVFSAVVFGA-MAVGQVSSFAPD---YAKAKISAAHIIMIIEKTPLID 1018
Query: 282 CLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
S G P + G ++ +V F+YP+R DI +L+G SL +K G+++ALVGSSGCGKST+
Sbjct: 1019 SYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTV 1078
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPE-- 399
+QLL+R YDP G V LDG+ +K LN+ WLR+ LG+V QEP+LF +I +NIA G
Sbjct: 1079 VQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRV 1138
Query: 400 ATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLL 459
+ E++ R A+ A H FI++LPN Y T +G++G LSGGQKQRIAIAR+L+R+P +LLL
Sbjct: 1139 VSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLL 1198
Query: 460 DEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVE 519
DEATSALD SEK VQ ALD+A GRT + ++HRLSTI N I+ G + E GTH +
Sbjct: 1199 DEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQ 1258
Query: 520 LMKAKGFYHKLVTSGKETK 538
L+ KG Y +V+ TK
Sbjct: 1259 LLAQKGIYFSMVSVQAGTK 1277
>AB208970-1|BAD92207.1| 1062|Homo sapiens Multidrug resistance protein
1 variant protein.
Length = 1062
Score = 727 bits (1797), Expect = 0.0
Identities = 420/1049 (40%), Positives = 604/1049 (57%), Gaps = 57/1049 (5%)
Query: 139 REMESYSQAGKQAEEVLKSVKTVVAFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGF 198
+E+ +Y++AG AEEVL +++TV+AFGG+ E++RY LE A+ G ++ + + G
Sbjct: 24 KELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGA 83
Query: 199 NWVLTYSLNTIGFMYGTRLIIEDANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHME 258
++L Y+ + F YGT L++ Y IG VL++ FSV + S+ P +E
Sbjct: 84 AFLLIYASYALAFWYGTTLVLSGE--------YSIGQVLTVFFSVLIGAFSVGQASPSIE 135
Query: 259 VFATARGAAASIFSLLDKHPKIDCLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGF 318
FA ARGAA IF ++D P ID S++G P + G + +VHFSYPSR ++KILKG
Sbjct: 136 AFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGL 195
Query: 319 SLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVV 378
+L ++ G++VALVG+SGCGKST +QL+QRLYDP +G V +DG++++T+N+ +LR +GVV
Sbjct: 196 NLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVV 255
Query: 379 GQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSG 438
QEPVLF TI +NI G T +++ + + A A++FI LP+ ++T++GERGA LSG
Sbjct: 256 SQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSG 315
Query: 439 GQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIV 498
GQKQRIAIAR+L+R P +LLLDEATSALD SE VQ ALD+A GRTT+ ++HRLST+
Sbjct: 316 GQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVR 375
Query: 499 NCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVT---SGKETK---EPEEIGTVLEEQET 552
N I D G I+E+G H ELMK KG Y KLVT +G E + +E + ++ E
Sbjct: 376 NADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDALEM 435
Query: 553 KQNGELQPAVRPEPDVKRRSVRKLH---RRQSAKGAHEWMATPRGSISSIMSTALQSHAY 609
N +R RRSVR R+ S K A + + P S IM L Y
Sbjct: 436 SSNDSRSSLIRKRST--RRSVRGSQAQDRKLSTKEALD-ESIPPVSFWRIMKLNLTEWPY 492
Query: 610 --------------SDTYXXXXXXXXXXXTPVSDWQLLKLNTPEW--LYLTVGSIAA--- 650
+ T + D + + N+ + L+L +G I+
Sbjct: 493 FVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFITF 552
Query: 651 FIQGACF----PVFALLLGYT------SGEIGYFDRESNTVGAVCARLSGDTAEVQGATG 700
F+QG F + L Y ++ +FD NT GA+ RL+ D A+V+GA G
Sbjct: 553 FLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIG 612
Query: 701 LRIGLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLM-VGSIWLEGIMSQKSQQDEREA 759
R+ +I Q +++ G I++ Y W+LTL+ +P++ + + ++S ++ +D++E
Sbjct: 613 SRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKE- 671
Query: 760 MESATAIATEAVVSIKTVQSLGIESLFITRFQDALIDACAAVVKKSRWRGLVLGLCIYVP 819
+E A IATEA+ + +TV SL E F + +L ++K+ G+ +
Sbjct: 672 LEGAGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMM 731
Query: 820 LLSYCSAVIYGAVLVAHGXXXXXXXXXXXXXXMYGAYMLGQSLVYAPSFNSAKTCGARIL 879
SY +GA LVAH ++GA +GQ +AP + AK A I+
Sbjct: 732 YFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHII 791
Query: 880 SIINREPRIRT--VDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTV 937
II + P I + +GL + GN + +V F+YPTR +L+G+ L V+ G+T+
Sbjct: 792 MIIEKTPLIDSYSTEGLMPN---TLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTL 848
Query: 938 ALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDR 997
ALVGSSGCGKSTV+QL++RFYDP G + LDG +I K L + LR LG+V QEPILFD
Sbjct: 849 ALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEI-KRLNVQWLRAHLGIVSQEPILFDC 907
Query: 998 TLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVC 1057
++AENIAYGDNSR + +E H FI SLP Y T KQR+
Sbjct: 908 SIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIA 967
Query: 1058 IARALIRSPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICV 1117
IARAL+R P +LLLDEATSALD SE+ V EALD A +GRTCI IAHRL+TI++AD+I V
Sbjct: 968 IARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVV 1027
Query: 1118 LDKGKIVEKGNHAELIGLKGHYWQLSKQQ 1146
G++ E G H +L+ KG Y+ + Q
Sbjct: 1028 FQNGRVKEHGTHQQLLAQKGIYFSMVSVQ 1056
Score = 349 bits (857), Expect = 5e-95
Identities = 187/499 (37%), Positives = 291/499 (58%), Gaps = 12/499 (2%)
Query: 44 IRKLFLTAVLRQDMTWFDTDSDFN--LASKMSENLMKLKEGMGEKLAVVSNLVGTSIICL 101
+R + ++LRQD++WFD + L ++++ + ++K +G +LAV++ + +
Sbjct: 570 LRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGI 629
Query: 102 CTAFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTV 161
+F GW+L L + ++P +A V + ++++ + AGK A E +++ +TV
Sbjct: 630 IISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRTV 689
Query: 162 VAFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIED 221
V+ E Y L+ + R+ G+ F + Y F +G L+
Sbjct: 690 VSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHK 749
Query: 222 ANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKID 281
+D ++ + ++ F MA ++ P +A A+ +AA I +++K P ID
Sbjct: 750 LMSFED----VLLVFSAVVFGA-MAVGQVSSFAPD---YAKAKISAAHIIMIIEKTPLID 801
Query: 282 CLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
S G P + G ++ +V F+YP+R DI +L+G SL +K G+++ALVGSSGCGKST+
Sbjct: 802 SYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTV 861
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPE-- 399
+QLL+R YDP G V LDG+ +K LN+ WLR+ LG+V QEP+LF +I +NIA G
Sbjct: 862 VQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRV 921
Query: 400 ATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLL 459
+ E++ R A+ A H FI++LPN Y T +G++G LSGGQKQRIAIAR+L+R+P +LLL
Sbjct: 922 VSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLL 981
Query: 460 DEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVE 519
DEATSALD SEK VQ ALD+A GRT + ++HRLSTI N I+ G + E GTH +
Sbjct: 982 DEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQ 1041
Query: 520 LMKAKGFYHKLVTSGKETK 538
L+ KG Y +V+ TK
Sbjct: 1042 LLAQKGIYFSMVSVQAGTK 1060
Score = 292 bits (716), Expect = 5e-78
Identities = 165/406 (40%), Positives = 235/406 (57%), Gaps = 6/406 (1%)
Query: 741 SIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFITRFQDALIDACAA 800
++W + I+S + + E A A A+A E + +I+TV + G + + R+ L +A
Sbjct: 12 AVWAK-ILSSFTDK-ELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRI 69
Query: 801 VVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXXXXMYGAYMLGQ 860
+KK+ + +G + SY A YG LV G + GA+ +GQ
Sbjct: 70 GIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQ 129
Query: 861 SLVYAPSFNSAKTCGARILSIINREPRIRTVDGLNDKQDWSASGNFSINDVEFSYPTRAH 920
+ +F +A+ I II+ +P I + K D + GN +V FSYP+R
Sbjct: 130 ASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPD-NIKGNLEFRNVHFSYPSRKE 188
Query: 921 QMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNR 980
ILKG++L V++G+TVALVG+SGCGKST +QL+QR YDPT G + +DG DI +++ +
Sbjct: 189 VKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDI-RTINVRF 247
Query: 981 LRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETN 1040
LR+ +GVV QEP+LF T+AENI YG + TMDE ++FI+ LP ++T
Sbjct: 248 LREIIGVVSQEPVLFATTIAENIRYGREN--VTMDEIEKAVKEANAYDFIMKLPHKFDTL 305
Query: 1041 XXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEALDHAAKGRTCI 1100
KQR+ IARAL+R+P++LLLDEATSALD SE V ALD A KGRT I
Sbjct: 306 VGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTI 365
Query: 1101 TIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSKQQ 1146
IAHRL+T+++AD+I D G IVEKGNH EL+ KG Y++L Q
Sbjct: 366 VIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQ 411
>M23234-1|AAA36207.1| 1279|Homo sapiens protein ( Human membrane
glycoprotein P (mdr3) mRNA, complete cds. ).
Length = 1279
Score = 466 bits (1150), Expect = e-130
Identities = 246/636 (38%), Positives = 382/636 (60%), Gaps = 37/636 (5%)
Query: 28 LSVALVSWSALKQITTIRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKL 87
+ V+ + +A +QI IR+ F A+LRQ++ WFD + L +++++++ K+ EG+G+K+
Sbjct: 133 IQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKV 192
Query: 88 AVVSNLVGTSIICLCTAFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQA 147
+ V T F GWKL L + + P +++ + S +E+ +Y++A
Sbjct: 193 GMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKA 252
Query: 148 GKQAEEVLKSVKTVVAFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLN 207
G AEE L +++TV+AFGG+N E++RY+ LE A+ G ++ + + G ++L Y+
Sbjct: 253 GAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASY 312
Query: 208 TIGFMYGTRLIIEDANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAA 267
+ F YG+ L+I + Y IG +++ FS+ + S+ P ++ FA ARGAA
Sbjct: 313 ALAFWYGSTLVIS--------KEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAA 364
Query: 268 ASIFSLLDKHPKIDCLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGES 327
IF ++D +PKID SE G P + G + DVHFSYPSR+++KILKG +L ++ G++
Sbjct: 365 YVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQT 424
Query: 328 VALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRG 387
VALVGSSGCGKST +QL+QRLYDP++G++ +DG++++ N+ +LR +GVV QEPVLF
Sbjct: 425 VALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFST 484
Query: 388 TIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIA 447
TI +NI G T +++ + + A A+EFI LP ++T++GERGA LSGGQKQRIAIA
Sbjct: 485 TIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIA 544
Query: 448 RSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMD 507
R+L+R P +LLLDEATSALD SE +VQAALD+A GRTT+ ++HRLST+ N I +
Sbjct: 545 RALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFE 604
Query: 508 QGTIIEQGTHVELMKAKGFYHKLVTSGKETKEPEEIGTVLEEQETKQNGELQPAVRPEPD 567
G I+EQG+H ELMK +G Y KLV + G+ ++ +E + N E + A R P+
Sbjct: 605 DGVIVEQGSHSELMKKEGVYFKLVNM-------QTSGSQIQSEEFELNDE-KAATRMAPN 656
Query: 568 VKRRSVRKLHRRQSAKGAHEWMATPRGSISSIMSTALQSHAYSDTYXXXXXXXXXXXTPV 627
+ +L R + K + + + L+++ PV
Sbjct: 657 GWKS---RLFRHSTQKNLKNSQMCQKSL--DVETDGLEANV----------------PPV 695
Query: 628 SDWQLLKLNTPEWLYLTVGSIAAFIQGACFPVFALL 663
S ++LKLN EW Y VG++ A G P F+++
Sbjct: 696 SFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVI 731
Score = 378 bits (930), Expect = e-104
Identities = 200/478 (41%), Positives = 287/478 (60%), Gaps = 4/478 (0%)
Query: 670 EIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTL 729
++ +FD N+ GA+ RL+ D A+VQGATG R+ LI Q +++ G I++ Y W+LTL
Sbjct: 799 DMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTL 858
Query: 730 VSTTFLPLMVGSIWLE-GIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFIT 788
+ +P++ S +E +++ +++D++E +E+A IATEA+ +I+TV SL E F +
Sbjct: 859 LLLAVVPIIAVSGIVEMKLLAGNAKRDKKE-LEAAGKIATEAIENIRTVVSLTQERKFES 917
Query: 789 RFQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXX 848
+ + L V+K+ G+ + SY +GA L+ +G
Sbjct: 918 MYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVF 977
Query: 849 XXXMYGAYMLGQSLVYAPSFNSAKTCGARILSIINREPRIRTVDGLNDKQDWSASGNFSI 908
++GA LG + +AP + AK A + + R+P I + K D GN +
Sbjct: 978 SAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPD-KFEGNITF 1036
Query: 909 NDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELD 968
N+V F+YPTRA+ +L+G+ L V+ G+T+ALVGSSGCGKSTV+QL++RFYDP G + LD
Sbjct: 1037 NEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLD 1096
Query: 969 GVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHN 1028
G + K L + LR QLG+V QEPILFD ++AENIAYGDNSR + DE H
Sbjct: 1097 GQE-AKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHP 1155
Query: 1029 FIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTE 1088
FI +LP YET KQR+ IARALIR P++LLLDEATSALD SE+ V E
Sbjct: 1156 FIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQE 1215
Query: 1089 ALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSKQQ 1146
ALD A +GRTCI IAHRL+TI++AD+I V G++ E G H +L+ KG Y+ + Q
Sbjct: 1216 ALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQ 1273
Score = 338 bits (832), Expect = 5e-92
Identities = 186/494 (37%), Positives = 292/494 (59%), Gaps = 14/494 (2%)
Query: 44 IRKLFLTAVLRQDMTWFDT--DSDFNLASKMSENLMKLKEGMGEKLAVVSNLVGTSIICL 101
+R + A+LRQDM+WFD +S L+++++ + +++ G +LA+++ + +
Sbjct: 787 LRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGI 846
Query: 102 CTAFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTV 161
+F GW+L L + V+P ++ + ++ R+ + AGK A E +++++TV
Sbjct: 847 IISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTV 906
Query: 162 VAFGGEN-IEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIE 220
V+ E E + L P S + ++ G+ + Y F +G LI+
Sbjct: 907 VSLTQERKFESMYVEKLYGPYRNSVQKAHIY-GITFSISQAFMYFSYAGCFRFGAYLIVN 965
Query: 221 DANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKI 280
+ D +I + +I F +A + P +A A+ +AA +F L ++ P I
Sbjct: 966 GHMRFRD----VILVFSAIVFGA-VALGHASSFAPD---YAKAKLSAAHLFMLFERQPLI 1017
Query: 281 DCLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKST 340
D SE G P + G I+ +V F+YP+R+++ +L+G SL +K G+++ALVGSSGCGKST
Sbjct: 1018 DSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKST 1077
Query: 341 ILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPE- 399
++QLL+R YDP G+V LDG+ K LN+ WLR+ LG+V QEP+LF +I +NIA G
Sbjct: 1078 VVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSR 1137
Query: 400 -ATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLL 458
+ +++ A+ A H FI+ LP+ YET +G++G LSGGQKQRIAIAR+L+R+P +LL
Sbjct: 1138 VVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILL 1197
Query: 459 LDEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHV 518
LDEATSALD SEK VQ ALD+A GRT + ++HRLSTI N I+ G + E GTH
Sbjct: 1198 LDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQ 1257
Query: 519 ELMKAKGFYHKLVT 532
+L+ KG Y +V+
Sbjct: 1258 QLLAQKGIYFSMVS 1271
Score = 336 bits (825), Expect = 3e-91
Identities = 191/479 (39%), Positives = 278/479 (58%), Gaps = 10/479 (2%)
Query: 670 EIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTL 729
EIG+FD T + RL+ D +++ G ++G+ Q ++ GFI+ WKLTL
Sbjct: 161 EIGWFDINDTT--ELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTL 218
Query: 730 VSTTFLPLM--VGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFI 787
V P++ ++W + I+S S + E A A A+A EA+ +I+TV + G ++ +
Sbjct: 219 VIMAISPILGLSAAVWAK-ILSAFSDK-ELAAYAKAGAVAEEALGAIRTVIAFGGQNKEL 276
Query: 788 TRFQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXX 847
R+Q L +A +KK+ + +G+ + SY A YG+ LV
Sbjct: 277 ERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTV 336
Query: 848 XXXXMYGAYMLGQSLVYAPSFNSAKTCGARILSIINREPRIRTVDGLNDKQDWSASGNFS 907
+ GA+ +GQ+ +F +A+ I II+ P+I + K D S GN
Sbjct: 337 FFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPD-SIKGNLE 395
Query: 908 INDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIEL 967
NDV FSYP+RA+ ILKG++L V++G+TVALVGSSGCGKST +QLIQR YDP G I +
Sbjct: 396 FNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINI 455
Query: 968 DGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXH 1027
DG DI ++ +N LR+ +GVV QEP+LF T+AENI YG + TMDE +
Sbjct: 456 DGQDI-RNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGN--VTMDEIKKAVKEANAY 512
Query: 1028 NFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVT 1087
FI+ LP+ ++T KQR+ IARAL+R+P++LLLDEATSALD SE V
Sbjct: 513 EFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQ 572
Query: 1088 EALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSKQQ 1146
ALD A +GRT I IAHRL+T+++AD+I + G IVE+G+H+EL+ +G Y++L Q
Sbjct: 573 AALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQ 631
>EF034088-1|ABJ53424.1| 1286|Homo sapiens ATP-binding cassette,
sub-family B (MDR/TAP), member 4 protein.
Length = 1286
Score = 466 bits (1150), Expect = e-130
Identities = 246/636 (38%), Positives = 382/636 (60%), Gaps = 37/636 (5%)
Query: 28 LSVALVSWSALKQITTIRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKL 87
+ V+ + +A +QI IR+ F A+LRQ++ WFD + L +++++++ K+ EG+G+K+
Sbjct: 133 IQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKV 192
Query: 88 AVVSNLVGTSIICLCTAFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQA 147
+ V T F GWKL L + + P +++ + S +E+ +Y++A
Sbjct: 193 GMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKA 252
Query: 148 GKQAEEVLKSVKTVVAFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLN 207
G AEE L +++TV+AFGG+N E++RY+ LE A+ G ++ + + G ++L Y+
Sbjct: 253 GAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASY 312
Query: 208 TIGFMYGTRLIIEDANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAA 267
+ F YG+ L+I + Y IG +++ FS+ + S+ P ++ FA ARGAA
Sbjct: 313 ALAFWYGSTLVIS--------KEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAA 364
Query: 268 ASIFSLLDKHPKIDCLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGES 327
IF ++D +PKID SE G P + G + DVHFSYPSR+++KILKG +L ++ G++
Sbjct: 365 YVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQT 424
Query: 328 VALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRG 387
VALVGSSGCGKST +QL+QRLYDP++G++ +DG++++ N+ +LR +GVV QEPVLF
Sbjct: 425 VALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFST 484
Query: 388 TIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIA 447
TI +NI G T +++ + + A A+EFI LP ++T++GERGA LSGGQKQRIAIA
Sbjct: 485 TIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIA 544
Query: 448 RSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMD 507
R+L+R P +LLLDEATSALD SE +VQAALD+A GRTT+ ++HRLST+ N I +
Sbjct: 545 RALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFE 604
Query: 508 QGTIIEQGTHVELMKAKGFYHKLVTSGKETKEPEEIGTVLEEQETKQNGELQPAVRPEPD 567
G I+EQG+H ELMK +G Y KLV + G+ ++ +E + N E + A R P+
Sbjct: 605 DGVIVEQGSHSELMKKEGVYFKLVNM-------QTSGSQIQSEEFELNDE-KAATRMAPN 656
Query: 568 VKRRSVRKLHRRQSAKGAHEWMATPRGSISSIMSTALQSHAYSDTYXXXXXXXXXXXTPV 627
+ +L R + K + + + L+++ PV
Sbjct: 657 GWKS---RLFRHSTQKNLKNSQMCQKSL--DVETDGLEANV----------------PPV 695
Query: 628 SDWQLLKLNTPEWLYLTVGSIAAFIQGACFPVFALL 663
S ++LKLN EW Y VG++ A G P F+++
Sbjct: 696 SFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVI 731
Score = 369 bits (909), Expect = e-101
Identities = 199/484 (41%), Positives = 287/484 (59%), Gaps = 9/484 (1%)
Query: 670 EIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTL 729
++ +FD N+ GA+ RL+ D A+VQGATG R+ LI Q +++ G I++ Y W+LTL
Sbjct: 799 DMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTL 858
Query: 730 VSTTFLPLMVGSIWLE-GIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFIT 788
+ +P++ S +E +++ +++D++E +E+A IATEA+ +I+TV SL E F +
Sbjct: 859 LLLAVVPIIAVSGIVEMKLLAGNAKRDKKE-LEAAGKIATEAIENIRTVVSLTQERKFES 917
Query: 789 RFQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXX 848
+ + L V+K+ G+ + SY +GA L+ +G
Sbjct: 918 MYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVF 977
Query: 849 XXXMYGAYMLGQSLVYAPSFNSAKTCGARILSIINREPRIRTVDGLNDKQDWSASGNFSI 908
++GA LG + +AP + AK A + + R+P I + K D GN +
Sbjct: 978 SAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPD-KFEGNITF 1036
Query: 909 NDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELD 968
N+V F+YPTRA+ +L+G+ L V+ G+T+ALVGSSGCGKSTV+QL++RFYDP G + +D
Sbjct: 1037 NEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVD 1096
Query: 969 -GVDI-----TKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXX 1022
G + K L + LR QLG+V QEPILFD ++AENIAYGDNSR + DE
Sbjct: 1097 FGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAK 1156
Query: 1023 XXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANS 1082
H FI +LP YET KQR+ IARALIR P++LLLDEATSALD S
Sbjct: 1157 AANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTES 1216
Query: 1083 ERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQL 1142
E+ V EALD A +GRTCI IAHRL+TI++AD+I V G++ E G H +L+ KG Y+ +
Sbjct: 1217 EKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSM 1276
Query: 1143 SKQQ 1146
Q
Sbjct: 1277 VSVQ 1280
Score = 336 bits (825), Expect = 3e-91
Identities = 191/479 (39%), Positives = 278/479 (58%), Gaps = 10/479 (2%)
Query: 670 EIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTL 729
EIG+FD T + RL+ D +++ G ++G+ Q ++ GFI+ WKLTL
Sbjct: 161 EIGWFDINDTT--ELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTL 218
Query: 730 VSTTFLPLM--VGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFI 787
V P++ ++W + I+S S + E A A A+A EA+ +I+TV + G ++ +
Sbjct: 219 VIMAISPILGLSAAVWAK-ILSAFSDK-ELAAYAKAGAVAEEALGAIRTVIAFGGQNKEL 276
Query: 788 TRFQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXX 847
R+Q L +A +KK+ + +G+ + SY A YG+ LV
Sbjct: 277 ERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTV 336
Query: 848 XXXXMYGAYMLGQSLVYAPSFNSAKTCGARILSIINREPRIRTVDGLNDKQDWSASGNFS 907
+ GA+ +GQ+ +F +A+ I II+ P+I + K D S GN
Sbjct: 337 FFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPD-SIKGNLE 395
Query: 908 INDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIEL 967
NDV FSYP+RA+ ILKG++L V++G+TVALVGSSGCGKST +QLIQR YDP G I +
Sbjct: 396 FNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINI 455
Query: 968 DGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXH 1027
DG DI ++ +N LR+ +GVV QEP+LF T+AENI YG + TMDE +
Sbjct: 456 DGQDI-RNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGN--VTMDEIKKAVKEANAY 512
Query: 1028 NFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVT 1087
FI+ LP+ ++T KQR+ IARAL+R+P++LLLDEATSALD SE V
Sbjct: 513 EFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQ 572
Query: 1088 EALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSKQQ 1146
ALD A +GRT I IAHRL+T+++AD+I + G IVE+G+H+EL+ +G Y++L Q
Sbjct: 573 AALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQ 631
Score = 329 bits (809), Expect = 3e-89
Identities = 186/501 (37%), Positives = 292/501 (58%), Gaps = 21/501 (4%)
Query: 44 IRKLFLTAVLRQDMTWFDT--DSDFNLASKMSENLMKLKEGMGEKLAVVSNLVGTSIICL 101
+R + A+LRQDM+WFD +S L+++++ + +++ G +LA+++ + +
Sbjct: 787 LRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGI 846
Query: 102 CTAFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTV 161
+F GW+L L + V+P ++ + ++ R+ + AGK A E +++++TV
Sbjct: 847 IISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTV 906
Query: 162 VAFGGEN-IEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIE 220
V+ E E + L P S + ++ G+ + Y F +G LI+
Sbjct: 907 VSLTQERKFESMYVEKLYGPYRNSVQKAHIY-GITFSISQAFMYFSYAGCFRFGAYLIVN 965
Query: 221 DANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKI 280
+ D +I + +I F +A + P +A A+ +AA +F L ++ P I
Sbjct: 966 GHMRFRD----VILVFSAIVFGA-VALGHASSFAPD---YAKAKLSAAHLFMLFERQPLI 1017
Query: 281 DCLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKST 340
D SE G P + G I+ +V F+YP+R+++ +L+G SL +K G+++ALVGSSGCGKST
Sbjct: 1018 DSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKST 1077
Query: 341 ILQLLQRLYDPNQGSV-------KLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNI 393
++QLL+R YDP G+V LDG+ K LN+ WLR+ LG+V QEP+LF +I +NI
Sbjct: 1078 VVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENI 1137
Query: 394 AIGYPE--ATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLL 451
A G + +++ A+ A H FI+ LP+ YET +G++G LSGGQKQRIAIAR+L+
Sbjct: 1138 AYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALI 1197
Query: 452 REPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTI 511
R+P +LLLDEATSALD SEK VQ ALD+A GRT + ++HRLSTI N I+ G +
Sbjct: 1198 RQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRV 1257
Query: 512 IEQGTHVELMKAKGFYHKLVT 532
E GTH +L+ KG Y +V+
Sbjct: 1258 KEHGTHQQLLAQKGIYFSMVS 1278
>BC042531-1|AAH42531.1| 1286|Homo sapiens ATP-binding cassette,
sub-family B (MDR/TAP), member 4 protein.
Length = 1286
Score = 465 bits (1146), Expect = e-130
Identities = 246/636 (38%), Positives = 381/636 (59%), Gaps = 37/636 (5%)
Query: 28 LSVALVSWSALKQITTIRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKL 87
+ V+ + +A +QI IR+ F A+LRQ++ WFD + L +++++++ K+ EG+G+K+
Sbjct: 133 IQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKV 192
Query: 88 AVVSNLVGTSIICLCTAFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQA 147
+ V T F GWKL L + + P +++ + S +E+ +Y++A
Sbjct: 193 GMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKA 252
Query: 148 GKQAEEVLKSVKTVVAFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLN 207
G AEE L +++TV+AFGG+N E++RY+ LE A+ G ++ + + G ++L Y+
Sbjct: 253 GAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASY 312
Query: 208 TIGFMYGTRLIIEDANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAA 267
+ F YG+ L+I + Y IG +++ FS+ + S P ++ FA ARGAA
Sbjct: 313 ALAFWYGSTLVIS--------KEYTIGNAMTVFFSILIGAFSAGQAAPCIDAFANARGAA 364
Query: 268 ASIFSLLDKHPKIDCLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGES 327
IF ++D +PKID SE G P + G + DVHFSYPSR+++KILKG +L ++ G++
Sbjct: 365 YVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQT 424
Query: 328 VALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRG 387
VALVGSSGCGKST +QL+QRLYDP++G++ +DG++++ N+ +LR +GVV QEPVLF
Sbjct: 425 VALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFST 484
Query: 388 TIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIA 447
TI +NI G T +++ + + A A+EFI LP ++T++GERGA LSGGQKQRIAIA
Sbjct: 485 TIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIA 544
Query: 448 RSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMD 507
R+L+R P +LLLDEATSALD SE +VQAALD+A GRTT+ ++HRLST+ N I +
Sbjct: 545 RALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFE 604
Query: 508 QGTIIEQGTHVELMKAKGFYHKLVTSGKETKEPEEIGTVLEEQETKQNGELQPAVRPEPD 567
G I+EQG+H ELMK +G Y KLV + G+ ++ +E + N E + A R P+
Sbjct: 605 DGVIVEQGSHSELMKKEGVYFKLVNM-------QTSGSQIQSEEFELNDE-KAATRMAPN 656
Query: 568 VKRRSVRKLHRRQSAKGAHEWMATPRGSISSIMSTALQSHAYSDTYXXXXXXXXXXXTPV 627
+ +L R + K + + + L+++ PV
Sbjct: 657 GWKS---RLFRHSTQKNLKNSQMCQKSL--DVETDGLEANV----------------PPV 695
Query: 628 SDWQLLKLNTPEWLYLTVGSIAAFIQGACFPVFALL 663
S ++LKLN EW Y VG++ A G P F+++
Sbjct: 696 SFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVI 731
Score = 369 bits (909), Expect = e-101
Identities = 199/484 (41%), Positives = 287/484 (59%), Gaps = 9/484 (1%)
Query: 670 EIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTL 729
++ +FD N+ GA+ RL+ D A+VQGATG R+ LI Q +++ G I++ Y W+LTL
Sbjct: 799 DMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTL 858
Query: 730 VSTTFLPLMVGSIWLE-GIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFIT 788
+ +P++ S +E +++ +++D++E +E+A IATEA+ +I+TV SL E F +
Sbjct: 859 LLLAVVPIIAVSGIVEMKLLAGNAKRDKKE-LEAAGKIATEAIENIRTVVSLTQERKFES 917
Query: 789 RFQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXX 848
+ + L V+K+ G+ + SY +GA L+ +G
Sbjct: 918 MYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVF 977
Query: 849 XXXMYGAYMLGQSLVYAPSFNSAKTCGARILSIINREPRIRTVDGLNDKQDWSASGNFSI 908
++GA LG + +AP + AK A + + R+P I + K D GN +
Sbjct: 978 SAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPD-KFEGNITF 1036
Query: 909 NDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELD 968
N+V F+YPTRA+ +L+G+ L V+ G+T+ALVGSSGCGKSTV+QL++RFYDP G + +D
Sbjct: 1037 NEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVD 1096
Query: 969 -GVDI-----TKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXX 1022
G + K L + LR QLG+V QEPILFD ++AENIAYGDNSR + DE
Sbjct: 1097 FGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAK 1156
Query: 1023 XXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANS 1082
H FI +LP YET KQR+ IARALIR P++LLLDEATSALD S
Sbjct: 1157 AANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTES 1216
Query: 1083 ERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQL 1142
E+ V EALD A +GRTCI IAHRL+TI++AD+I V G++ E G H +L+ KG Y+ +
Sbjct: 1217 EKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSM 1276
Query: 1143 SKQQ 1146
Q
Sbjct: 1277 VSVQ 1280
Score = 335 bits (823), Expect = 6e-91
Identities = 191/479 (39%), Positives = 277/479 (57%), Gaps = 10/479 (2%)
Query: 670 EIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTL 729
EIG+FD T + RL+ D +++ G ++G+ Q ++ GFI+ WKLTL
Sbjct: 161 EIGWFDINDTT--ELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTL 218
Query: 730 VSTTFLPLM--VGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFI 787
V P++ ++W + I+S S + E A A A+A EA+ +I+TV + G ++ +
Sbjct: 219 VIMAISPILGLSAAVWAK-ILSAFSDK-ELAAYAKAGAVAEEALGAIRTVIAFGGQNKEL 276
Query: 788 TRFQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXX 847
R+Q L +A +KK+ + +G+ + SY A YG+ LV
Sbjct: 277 ERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTV 336
Query: 848 XXXXMYGAYMLGQSLVYAPSFNSAKTCGARILSIINREPRIRTVDGLNDKQDWSASGNFS 907
+ GA+ GQ+ +F +A+ I II+ P+I + K D S GN
Sbjct: 337 FFSILIGAFSAGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPD-SIKGNLE 395
Query: 908 INDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIEL 967
NDV FSYP+RA+ ILKG++L V++G+TVALVGSSGCGKST +QLIQR YDP G I +
Sbjct: 396 FNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINI 455
Query: 968 DGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXH 1027
DG DI ++ +N LR+ +GVV QEP+LF T+AENI YG + TMDE +
Sbjct: 456 DGQDI-RNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGN--VTMDEIKKAVKEANAY 512
Query: 1028 NFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVT 1087
FI+ LP+ ++T KQR+ IARAL+R+P++LLLDEATSALD SE V
Sbjct: 513 EFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQ 572
Query: 1088 EALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSKQQ 1146
ALD A +GRT I IAHRL+T+++AD+I + G IVE+G+H+EL+ +G Y++L Q
Sbjct: 573 AALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQ 631
Score = 329 bits (809), Expect = 3e-89
Identities = 186/501 (37%), Positives = 292/501 (58%), Gaps = 21/501 (4%)
Query: 44 IRKLFLTAVLRQDMTWFDT--DSDFNLASKMSENLMKLKEGMGEKLAVVSNLVGTSIICL 101
+R + A+LRQDM+WFD +S L+++++ + +++ G +LA+++ + +
Sbjct: 787 LRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGI 846
Query: 102 CTAFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTV 161
+F GW+L L + V+P ++ + ++ R+ + AGK A E +++++TV
Sbjct: 847 IISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTV 906
Query: 162 VAFGGEN-IEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIE 220
V+ E E + L P S + ++ G+ + Y F +G LI+
Sbjct: 907 VSLTQERKFESMYVEKLYGPYRNSVQKAHIY-GITFSISQAFMYFSYAGCFRFGAYLIVN 965
Query: 221 DANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKI 280
+ D +I + +I F +A + P +A A+ +AA +F L ++ P I
Sbjct: 966 GHMRFRD----VILVFSAIVFGA-VALGHASSFAPD---YAKAKLSAAHLFMLFERQPLI 1017
Query: 281 DCLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKST 340
D SE G P + G I+ +V F+YP+R+++ +L+G SL +K G+++ALVGSSGCGKST
Sbjct: 1018 DSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKST 1077
Query: 341 ILQLLQRLYDPNQGSV-------KLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNI 393
++QLL+R YDP G+V LDG+ K LN+ WLR+ LG+V QEP+LF +I +NI
Sbjct: 1078 VVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENI 1137
Query: 394 AIGYPE--ATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLL 451
A G + +++ A+ A H FI+ LP+ YET +G++G LSGGQKQRIAIAR+L+
Sbjct: 1138 AYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALI 1197
Query: 452 REPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTI 511
R+P +LLLDEATSALD SEK VQ ALD+A GRT + ++HRLSTI N I+ G +
Sbjct: 1198 RQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRV 1257
Query: 512 IEQGTHVELMKAKGFYHKLVT 532
E GTH +L+ KG Y +V+
Sbjct: 1258 KEHGTHQQLLAQKGIYFSMVS 1278
>AF136523-1|AAD28285.1| 1321|Homo sapiens bile salt export pump
protein.
Length = 1321
Score = 442 bits (1089), Expect = e-123
Identities = 249/658 (37%), Positives = 369/658 (56%), Gaps = 32/658 (4%)
Query: 36 SALKQITTIRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAVVSNLVG 95
+A +QI +RK + ++R ++ WFD +S L ++ S+++ K+ + + +++A+ +
Sbjct: 166 AAARQIQKMRKFYFRRIMRMEIGWFDCNSVGELNTRFSDDINKINDAIADQMALFIQRMT 225
Query: 96 TSIICLCTAFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVL 155
++I F GWKL L I+V P + + + +K + E+++Y++AG A+EV+
Sbjct: 226 STICGFLLGFFRGWKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKAGVVADEVI 285
Query: 156 KSVKTVVAFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGT 215
S++TV AFGGE EV+RY+ L A+ G R+G+ G GF W L + + F YG+
Sbjct: 286 SSMRTVAAFGGEKREVERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYALAFWYGS 345
Query: 216 RLIIEDANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLD 275
L++ DE Y G ++ I SV + ++ P +E FAT R AA SIF +D
Sbjct: 346 TLVL-------DEGEYTPGTLVQIFLSVIVGALNLGNASPCLEAFATGRAAATSIFETID 398
Query: 276 KHPKIDCLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSG 335
+ P IDC+SE G R+ GEI +V F YPSR ++KIL ++ IKPGE ALVG SG
Sbjct: 399 RKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMAIKPGEMTALVGPSG 458
Query: 336 CGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAI 395
GKST LQL+QR YDP +G V +DG ++++LNI WLR +G+V QEPVLF TI +NI
Sbjct: 459 AGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRY 518
Query: 396 GYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPA 455
G +AT ED+ + A+ A A+ FI +LP ++T++GE G +SGGQKQR+AIAR+L+R P
Sbjct: 519 GREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPK 578
Query: 456 VLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQG 515
+LLLD ATSALD SE VQ L + G T ++V+HRLST+ II + GT +E+G
Sbjct: 579 ILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERG 638
Query: 516 THVELMKAKGFYHKLVT---SGKETKEPEEIGTVLEEQ---ETKQNGELQPAVRPEPDVK 569
TH EL++ KG Y LVT G + E+I E+ T G Q D
Sbjct: 639 THEELLERKGVYFTLVTLQSQGNQALNEEDIKDATEDDMLARTFSRGSYQ-------DSL 691
Query: 570 RRSVRKLHRRQSAKGAHEWMATPRGSISSIMSTALQSHAYSDTYXXXXXXXXXXXTPVSD 629
R S+R+ + Q + HE P ++ ST Y + P
Sbjct: 692 RASIRQRSKSQLSYLVHE----PPLAVVDHKST------YEEDRKDKDIPVQEEVEPAPV 741
Query: 630 WQLLKLNTPEWLYLTVGSIAAFIQGACFPVFALLLGYTSGEIGYFDRES--NTVGAVC 685
++LK + PEW Y+ VGS+ A + G P++A L G D+E + + VC
Sbjct: 742 RRILKFSAPEWPYMLVGSVGAAVNGTVTPLYAFLFSQILGTFSIPDKEEQRSQINGVC 799
Score = 357 bits (878), Expect = 1e-97
Identities = 179/473 (37%), Positives = 276/473 (58%), Gaps = 2/473 (0%)
Query: 670 EIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTL 729
+I +FD N+ GA+ RL+ D ++VQGA G +IG+I+ F++VTV I+A S++WKL+L
Sbjct: 843 DIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSL 902
Query: 730 VSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFITR 789
V F P + S + M +++A+E I EA+ +I+TV +G E FI
Sbjct: 903 VILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEA 962
Query: 790 FQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXX 849
+ L ++K+ G + ++ ++ YG L+++
Sbjct: 963 LETELEKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVIS 1022
Query: 850 XXMYGAYMLGQSLVYAPSFNSAKTCGARILSIINREPRIRTVDGLNDKQDWSASGNFSIN 909
+ A LG++ Y PS+ AK AR +++R+P I + +K D + G
Sbjct: 1023 AVVLSATALGRAFSYTPSYAKAKISAARFFQLLDRQPPISVYNTAGEKWD-NFQGKIDFV 1081
Query: 910 DVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDG 969
D +F+YP+R +L G+ + + G+T+A VGSSGCGKST +QL++RFYDP G + +DG
Sbjct: 1082 DCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDG 1141
Query: 970 VDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNF 1029
D +K + + LR +G+V QEP+LF ++ +NI YGDN+++ M+ H+F
Sbjct: 1142 HD-SKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDF 1200
Query: 1030 IVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEA 1089
++SLP+ YETN KQR+ IARA++R P++LLLDEATSALD SE+ V A
Sbjct: 1201 VMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVA 1260
Query: 1090 LDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQL 1142
LD A +GRTCI IAHRL+TI++ADII V+ +G ++EKG H EL+ KG Y++L
Sbjct: 1261 LDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKL 1313
Score = 349 bits (859), Expect = 3e-95
Identities = 187/495 (37%), Positives = 285/495 (57%), Gaps = 12/495 (2%)
Query: 44 IRKLFLTAVLRQDMTWFDT--DSDFNLASKMSENLMKLKEGMGEKLAVVSNLVGTSIICL 101
+RK A+L QD+ WFD +S L ++++ + +++ G ++ ++ N + +
Sbjct: 831 LRKFGFRAMLGQDIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAM 890
Query: 102 CTAFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTV 161
AF WKL+L + PF ++ T T + R+ ++ G+ E L +++TV
Sbjct: 891 IIAFSFSWKLSLVILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTV 950
Query: 162 VAFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIED 221
G E ++ ++ LE + ++ G F + + N+ + YG LI +
Sbjct: 951 AGIGKERRFIEALETELEKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNE 1010
Query: 222 ANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKID 281
+Y+ ++ ++ S ++ + + +A A+ +AA F LLD+ P I
Sbjct: 1011 GL----HFSYVFRVISAVVLSATALGRAFS----YTPSYAKAKISAARFFQLLDRQPPIS 1062
Query: 282 CLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
+ AG G+I D F+YPSR D ++L G S+ I PG+++A VGSSGCGKST
Sbjct: 1063 VYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTS 1122
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIG--YPE 399
+QLL+R YDP+QG V +DG + K +N+ +LRS++G+V QEPVLF +I DNI G E
Sbjct: 1123 IQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKE 1182
Query: 400 ATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLL 459
E V A+ A H+F+ +LP YET +G +G+ LS G+KQRIAIAR+++R+P +LLL
Sbjct: 1183 IPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLL 1242
Query: 460 DEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVE 519
DEATSALD SEK VQ ALD+A GRT + ++HRLSTI N I M QG +IE+GTH E
Sbjct: 1243 DEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEE 1302
Query: 520 LMKAKGFYHKLVTSG 534
LM KG Y+KLVT+G
Sbjct: 1303 LMAQKGAYYKLVTTG 1317
Score = 286 bits (702), Expect = 3e-76
Identities = 175/480 (36%), Positives = 252/480 (52%), Gaps = 9/480 (1%)
Query: 670 EIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTL 729
EIG+FD N+VG + R S D ++ A ++ L +Q +S GF++ WKLTL
Sbjct: 186 EIGWFD--CNSVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWKLTL 243
Query: 730 VSTTFLPLM-VGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFIT 788
V + PL+ +G+ + G+ K E +A A +A E + S++TV + G E +
Sbjct: 244 VIISVSPLIGIGAATI-GLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKREVE 302
Query: 789 RFQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVA-HGXXXXXXXXXX 847
R++ L+ A ++K G G + L Y A YG+ LV G
Sbjct: 303 RYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYALAFWYGSTLVLDEGEYTPGTLVQI 362
Query: 848 XXXXMYGAYMLGQSLVYAPSFNSAKTCGARILSIINREPRIRTVDGLNDKQDWSASGNFS 907
+ GA LG + +F + + I I+R+P I + K D G
Sbjct: 363 FLSVIVGALNLGNASPCLEAFATGRAAATSIFETIDRKPIIDCMSEDGYKLD-RIKGEIE 421
Query: 908 INDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIEL 967
++V F YP+R IL +++ ++ G+ ALVG SG GKST LQLIQRFYDP G + +
Sbjct: 422 FHNVTFHYPSRPEVKILNDLNMAIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTV 481
Query: 968 DGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXH 1027
DG DI +SL + LR Q+G+V+QEP+LF T+AENI YG TM++ +
Sbjct: 482 DGHDI-RSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDA--TMEDIVQAAKEANAY 538
Query: 1028 NFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVT 1087
NFI+ LP+ ++T KQRV IARALIR+P++LLLD ATSALD SE V
Sbjct: 539 NFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQ 598
Query: 1088 EALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSKQQN 1147
E L G T I++AHRL+T++ AD I + G VE+G H EL+ KG Y+ L Q+
Sbjct: 599 EVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTLQS 658
>AF091582-1|AAC77455.1| 1321|Homo sapiens bile salt export pump
protein.
Length = 1321
Score = 442 bits (1089), Expect = e-123
Identities = 249/658 (37%), Positives = 369/658 (56%), Gaps = 32/658 (4%)
Query: 36 SALKQITTIRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAVVSNLVG 95
+A +QI +RK + ++R ++ WFD +S L ++ S+++ K+ + + +++A+ +
Sbjct: 166 AAARQIQKMRKFYFRRIMRMEIGWFDCNSVGELNTRFSDDINKINDAIADQMALFIQRMT 225
Query: 96 TSIICLCTAFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVL 155
++I F GWKL L I+V P + + + +K + E+++Y++AG A+EV+
Sbjct: 226 STICGFLLGFFRGWKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKAGVVADEVI 285
Query: 156 KSVKTVVAFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGT 215
S++TV AFGGE EV+RY+ L A+ G R+G+ G GF W L + + F YG+
Sbjct: 286 SSMRTVAAFGGEKREVERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYAVAFWYGS 345
Query: 216 RLIIEDANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLD 275
L++ DE Y G ++ I SV + ++ P +E FAT R AA SIF +D
Sbjct: 346 TLVL-------DEGEYTPGTLVQIFLSVIVGALNLGNASPCLEAFATGRAAATSIFETID 398
Query: 276 KHPKIDCLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSG 335
+ P IDC+SE G R+ GEI +V F YPSR ++KIL ++ IKPGE ALVG SG
Sbjct: 399 RKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSG 458
Query: 336 CGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAI 395
GKST LQL+QR YDP +G V +DG ++++LNI WLR +G+V QEPVLF TI +NI
Sbjct: 459 AGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRY 518
Query: 396 GYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPA 455
G +AT ED+ + A+ A A+ FI +LP ++T++GE G +SGGQKQR+AIAR+L+R P
Sbjct: 519 GREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPK 578
Query: 456 VLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQG 515
+LLLD ATSALD SE VQ L + G T ++V+HRLST+ II + GT +E+G
Sbjct: 579 ILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERG 638
Query: 516 THVELMKAKGFYHKLVT---SGKETKEPEEIGTVLEEQ---ETKQNGELQPAVRPEPDVK 569
TH EL++ KG Y LVT G + E+I E+ T G Q D
Sbjct: 639 THEELLERKGVYFTLVTLQSQGNQALNEEDIKDATEDDMLARTFSRGSYQ-------DSL 691
Query: 570 RRSVRKLHRRQSAKGAHEWMATPRGSISSIMSTALQSHAYSDTYXXXXXXXXXXXTPVSD 629
R S+R+ + Q + HE P ++ ST Y + P
Sbjct: 692 RASIRQRSKSQLSYLVHE----PPLAVVDHKST------YEEDRKDKDIPVQEEVEPAPV 741
Query: 630 WQLLKLNTPEWLYLTVGSIAAFIQGACFPVFALLLGYTSGEIGYFDRES--NTVGAVC 685
++LK + PEW Y+ VGS+ A + G P++A L G D+E + + VC
Sbjct: 742 RRILKFSAPEWPYMLVGSVGAAVNGTVTPLYAFLFSQILGTFSIPDKEEQRSQINGVC 799
Score = 357 bits (878), Expect = 1e-97
Identities = 179/473 (37%), Positives = 276/473 (58%), Gaps = 2/473 (0%)
Query: 670 EIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTL 729
+I +FD N+ GA+ RL+ D ++VQGA G +IG+I+ F++VTV I+A S++WKL+L
Sbjct: 843 DIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSL 902
Query: 730 VSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFITR 789
V F P + S + M +++A+E I EA+ +I+TV +G E FI
Sbjct: 903 VILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEA 962
Query: 790 FQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXX 849
+ L ++K+ G + ++ ++ YG L+++
Sbjct: 963 LETELEKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVIS 1022
Query: 850 XXMYGAYMLGQSLVYAPSFNSAKTCGARILSIINREPRIRTVDGLNDKQDWSASGNFSIN 909
+ A LG++ Y PS+ AK AR +++R+P I + +K D + G
Sbjct: 1023 AVVLSATALGRAFSYTPSYAKAKISAARFFQLLDRQPPISVYNTAGEKWD-NFQGKIDFV 1081
Query: 910 DVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDG 969
D +F+YP+R +L G+ + + G+T+A VGSSGCGKST +QL++RFYDP G + +DG
Sbjct: 1082 DCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDG 1141
Query: 970 VDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNF 1029
D +K + + LR +G+V QEP+LF ++ +NI YGDN+++ M+ H+F
Sbjct: 1142 HD-SKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDF 1200
Query: 1030 IVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEA 1089
++SLP+ YETN KQR+ IARA++R P++LLLDEATSALD SE+ V A
Sbjct: 1201 VMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVA 1260
Query: 1090 LDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQL 1142
LD A +GRTCI IAHRL+TI++ADII V+ +G ++EKG H EL+ KG Y++L
Sbjct: 1261 LDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKL 1313
Score = 349 bits (859), Expect = 3e-95
Identities = 187/495 (37%), Positives = 285/495 (57%), Gaps = 12/495 (2%)
Query: 44 IRKLFLTAVLRQDMTWFDT--DSDFNLASKMSENLMKLKEGMGEKLAVVSNLVGTSIICL 101
+RK A+L QD+ WFD +S L ++++ + +++ G ++ ++ N + +
Sbjct: 831 LRKFGFRAMLGQDIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAM 890
Query: 102 CTAFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTV 161
AF WKL+L + PF ++ T T + R+ ++ G+ E L +++TV
Sbjct: 891 IIAFSFSWKLSLVILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTV 950
Query: 162 VAFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIED 221
G E ++ ++ LE + ++ G F + + N+ + YG LI +
Sbjct: 951 AGIGKERRFIEALETELEKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNE 1010
Query: 222 ANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKID 281
+Y+ ++ ++ S ++ + + +A A+ +AA F LLD+ P I
Sbjct: 1011 GL----HFSYVFRVISAVVLSATALGRAFS----YTPSYAKAKISAARFFQLLDRQPPIS 1062
Query: 282 CLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
+ AG G+I D F+YPSR D ++L G S+ I PG+++A VGSSGCGKST
Sbjct: 1063 VYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTS 1122
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIG--YPE 399
+QLL+R YDP+QG V +DG + K +N+ +LRS++G+V QEPVLF +I DNI G E
Sbjct: 1123 IQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKE 1182
Query: 400 ATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLL 459
E V A+ A H+F+ +LP YET +G +G+ LS G+KQRIAIAR+++R+P +LLL
Sbjct: 1183 IPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLL 1242
Query: 460 DEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVE 519
DEATSALD SEK VQ ALD+A GRT + ++HRLSTI N I M QG +IE+GTH E
Sbjct: 1243 DEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEE 1302
Query: 520 LMKAKGFYHKLVTSG 534
LM KG Y+KLVT+G
Sbjct: 1303 LMAQKGAYYKLVTTG 1317
Score = 286 bits (701), Expect = 4e-76
Identities = 175/480 (36%), Positives = 252/480 (52%), Gaps = 9/480 (1%)
Query: 670 EIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTL 729
EIG+FD N+VG + R S D ++ A ++ L +Q +S GF++ WKLTL
Sbjct: 186 EIGWFD--CNSVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWKLTL 243
Query: 730 VSTTFLPLM-VGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFIT 788
V + PL+ +G+ + G+ K E +A A +A E + S++TV + G E +
Sbjct: 244 VIISVSPLIGIGAATI-GLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKREVE 302
Query: 789 RFQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVA-HGXXXXXXXXXX 847
R++ L+ A ++K G G + L Y A YG+ LV G
Sbjct: 303 RYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYAVAFWYGSTLVLDEGEYTPGTLVQI 362
Query: 848 XXXXMYGAYMLGQSLVYAPSFNSAKTCGARILSIINREPRIRTVDGLNDKQDWSASGNFS 907
+ GA LG + +F + + I I+R+P I + K D G
Sbjct: 363 FLSVIVGALNLGNASPCLEAFATGRAAATSIFETIDRKPIIDCMSEDGYKLD-RIKGEIE 421
Query: 908 INDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIEL 967
++V F YP+R IL +++ ++ G+ ALVG SG GKST LQLIQRFYDP G + +
Sbjct: 422 FHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTV 481
Query: 968 DGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXH 1027
DG DI +SL + LR Q+G+V+QEP+LF T+AENI YG TM++ +
Sbjct: 482 DGHDI-RSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDA--TMEDIVQAAKEANAY 538
Query: 1028 NFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVT 1087
NFI+ LP+ ++T KQRV IARALIR+P++LLLD ATSALD SE V
Sbjct: 539 NFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQ 598
Query: 1088 EALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSKQQN 1147
E L G T I++AHRL+T++ AD I + G VE+G H EL+ KG Y+ L Q+
Sbjct: 599 EVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTLQS 658
>AC008177-1|AAY24305.1| 870|Homo sapiens unknown protein.
Length = 870
Score = 442 bits (1088), Expect = e-123
Identities = 249/658 (37%), Positives = 369/658 (56%), Gaps = 32/658 (4%)
Query: 36 SALKQITTIRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAVVSNLVG 95
+A +QI +RK + ++R ++ WFD +S L ++ S+++ K+ + + +++A+ +
Sbjct: 166 AAARQIQKMRKFYFRRIMRMEIGWFDCNSVGELNTRFSDDINKINDAIADQMALFIQRMT 225
Query: 96 TSIICLCTAFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVL 155
++I F GWKL L I+V P + + + +K + E+++Y++AG A+EV+
Sbjct: 226 STICGFLLGFFRGWKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKAGVVADEVI 285
Query: 156 KSVKTVVAFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGT 215
S++TV AFGGE EV+RY+ L A+ G R+G+ G GF W L + + F YG+
Sbjct: 286 SSMRTVAAFGGEKREVERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYALAFWYGS 345
Query: 216 RLIIEDANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLD 275
L++ DE Y G ++ I SV + ++ P +E FAT R AA SIF +D
Sbjct: 346 TLVL-------DEGEYTPGTLVQIFLSVIVGALNLGNASPCLEAFATGRAAATSIFETID 398
Query: 276 KHPKIDCLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSG 335
+ P IDC+SE G R+ GEI +V F YPSR ++KIL ++ IKPGE ALVG SG
Sbjct: 399 RKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSG 458
Query: 336 CGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAI 395
GKST LQL+QR YDP +G V +DG ++++LNI WLR +G+V QEPVLF TI +NI
Sbjct: 459 AGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRY 518
Query: 396 GYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPA 455
G +AT ED+ + A+ A A+ FI +LP ++T++GE G +SGGQKQR+AIAR+L+R P
Sbjct: 519 GREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPK 578
Query: 456 VLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQG 515
+LLLD ATSALD SE VQ L + G T ++V+HRLST+ II + GT +E+G
Sbjct: 579 ILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERG 638
Query: 516 THVELMKAKGFYHKLVT---SGKETKEPEEIGTVLEEQ---ETKQNGELQPAVRPEPDVK 569
TH EL++ KG Y LVT G + E+I E+ T G Q D
Sbjct: 639 THEELLERKGVYFTLVTLQSQGNQALNEEDIKDATEDDMLARTFSRGSYQ-------DSL 691
Query: 570 RRSVRKLHRRQSAKGAHEWMATPRGSISSIMSTALQSHAYSDTYXXXXXXXXXXXTPVSD 629
R S+R+ + Q + HE P ++ ST Y + P
Sbjct: 692 RASIRQRSKSQLSYLVHE----PPLAVVDHKST------YEEDRKDKDIPVQEEVEPAPV 741
Query: 630 WQLLKLNTPEWLYLTVGSIAAFIQGACFPVFALLLGYTSGEIGYFDRES--NTVGAVC 685
++LK + PEW Y+ VGS+ A + G P++A L G D+E + + VC
Sbjct: 742 RRILKFSAPEWPYMLVGSVGAAVNGTVTPLYAFLFSQILGTFSIPDKEEQRSQINGVC 799
Score = 286 bits (701), Expect = 4e-76
Identities = 175/480 (36%), Positives = 252/480 (52%), Gaps = 9/480 (1%)
Query: 670 EIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTL 729
EIG+FD N+VG + R S D ++ A ++ L +Q +S GF++ WKLTL
Sbjct: 186 EIGWFD--CNSVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWKLTL 243
Query: 730 VSTTFLPLM-VGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFIT 788
V + PL+ +G+ + G+ K E +A A +A E + S++TV + G E +
Sbjct: 244 VIISVSPLIGIGAATI-GLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKREVE 302
Query: 789 RFQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVA-HGXXXXXXXXXX 847
R++ L+ A ++K G G + L Y A YG+ LV G
Sbjct: 303 RYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYALAFWYGSTLVLDEGEYTPGTLVQI 362
Query: 848 XXXXMYGAYMLGQSLVYAPSFNSAKTCGARILSIINREPRIRTVDGLNDKQDWSASGNFS 907
+ GA LG + +F + + I I+R+P I + K D G
Sbjct: 363 FLSVIVGALNLGNASPCLEAFATGRAAATSIFETIDRKPIIDCMSEDGYKLD-RIKGEIE 421
Query: 908 INDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIEL 967
++V F YP+R IL +++ ++ G+ ALVG SG GKST LQLIQRFYDP G + +
Sbjct: 422 FHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTV 481
Query: 968 DGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXH 1027
DG DI +SL + LR Q+G+V+QEP+LF T+AENI YG TM++ +
Sbjct: 482 DGHDI-RSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDA--TMEDIVQAAKEANAY 538
Query: 1028 NFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVT 1087
NFI+ LP+ ++T KQRV IARALIR+P++LLLD ATSALD SE V
Sbjct: 539 NFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQ 598
Query: 1088 EALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSKQQN 1147
E L G T I++AHRL+T++ AD I + G VE+G H EL+ KG Y+ L Q+
Sbjct: 599 EVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTLQS 658
>BC104920-1|AAI04921.1| 812|Homo sapiens ATP-binding cassette,
sub-family B (MDR/TAP), member 5 protein.
Length = 812
Score = 346 bits (851), Expect = 2e-94
Identities = 181/479 (37%), Positives = 273/479 (56%), Gaps = 2/479 (0%)
Query: 670 EIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTL 729
+I +FD + N+ G + L+ D A++QGATG RIG++ Q +++ + I++ Y W++T
Sbjct: 335 DIAWFDEKENSTGGLTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTF 394
Query: 730 VSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFITR 789
+ + P++ + +E +++ ++ A IATEA+ +I+T+ SL E F
Sbjct: 395 LILSIAPVLAVTGMIETAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQM 454
Query: 790 FQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXX 849
+++ L KK++ G +Y + +GA L+ G
Sbjct: 455 YEEMLQTQHRNTSKKAQIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIVFT 514
Query: 850 XXMYGAYMLGQSLVYAPSFNSAKTCGARILSIINREPRIRTVDGLNDKQDWSASGNFSIN 909
YGA +G++LV AP ++ AK+ A + +++ ++P I + K D + GN
Sbjct: 515 AIAYGAMAIGETLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPD-TCEGNLEFR 573
Query: 910 DVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDG 969
+V F YP R IL+G+ L +E GKTVA VGSSGCGKST +QL+QR YDP G + DG
Sbjct: 574 EVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDG 633
Query: 970 VDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNF 1029
VD K L + LR Q+ +V QEP+LF+ ++AENIAYGDNSR +DE H+F
Sbjct: 634 VD-AKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSF 692
Query: 1030 IVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEA 1089
I LP+ Y T KQR+ IARAL++ P++LLLDEATSALD +SE+ V A
Sbjct: 693 IEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHA 752
Query: 1090 LDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSKQQNV 1148
LD A GRTC+ + HRL+ I++AD+I VL GKI E+G H EL+ + Y++L Q+V
Sbjct: 753 LDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVNAQSV 811
Score = 341 bits (838), Expect = 9e-93
Identities = 196/528 (37%), Positives = 297/528 (56%), Gaps = 15/528 (2%)
Query: 13 IGAFVSIIFSILCNV-LSVALVSWSALKQITT--IRKLFLTAVLRQDMTWFDT--DSDFN 67
I + + +I ++C V + + + +I T +R L A+L QD+ WFD +S
Sbjct: 289 IYSMIFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGG 348
Query: 68 LASKMSENLMKLKEGMGEKLAVVSNLVGTSIICLCTAFPLGWKLALACITVMPFSIMASV 127
L + ++ ++ +++ G ++ V++ + + +F GW++ +++ P + +
Sbjct: 349 LTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGM 408
Query: 128 ALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAFGGENIEVQRYKSLLEPAEISGSR 187
T T + ++ + AGK A E L++++T+V+ E Q Y+ +L+ + S+
Sbjct: 409 IETAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTSK 468
Query: 188 RGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDANKPDDERTYIIGIVLSITFSVYMAT 247
+ G F+ Y GF +G LI A + E +I+ +I +
Sbjct: 469 KAQIIGSCYAFSHAFIYFAYAAGFRFGAYLI--QAGRMTPEGMFIV--FTAIAYGAMAIG 524
Query: 248 QSITLCVPHMEVFATARGAAASIFSLLDKHPKIDCLSEAGSSPRRVIGEISLEDVHFSYP 307
+++ L P ++ A+ AA +F+LL+K P ID S+ G P G + +V F YP
Sbjct: 525 ETLVLA-PE---YSKAKSGAAHLFALLEKKPNIDSRSQEGKKPDTCEGNLEFREVSFFYP 580
Query: 308 SRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLN 367
R D+ IL+G SL I+ G++VA VGSSGCGKST +QLLQRLYDP QG V DG + K LN
Sbjct: 581 CRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELN 640
Query: 368 IGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPE--ATSEDVYRVAEMAYAHEFIKNLPNGY 425
+ WLRS + +V QEPVLF +I +NIA G +++ A A H FI+ LP Y
Sbjct: 641 VQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKY 700
Query: 426 ETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGR 485
T +G +GA LSGGQKQR+AIAR+LL++P +LLLDEATSALD SEK VQ ALD+A GR
Sbjct: 701 NTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGR 760
Query: 486 TTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTS 533
T L V+HRLS I N I+ + G I EQGTH EL++ + Y KLV +
Sbjct: 761 TCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVNA 808
Score = 193 bits (470), Expect = 4e-48
Identities = 95/198 (47%), Positives = 132/198 (66%)
Query: 358 LDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEF 417
+D +++ LN+ R +GVV QEPVLF TI +NI G + T E++ R A A A++F
Sbjct: 2 VDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDF 61
Query: 418 IKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAA 477
I PN + T++GE+GA +SGGQKQRIAIAR+L+R P +L+LDEATSALD S+ VQAA
Sbjct: 62 IMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAA 121
Query: 478 LDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSGKET 537
L++AS GRTT+ V+HRLSTI + I+ + G + E+G H ELM +G Y+ LV S
Sbjct: 122 LEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQDIK 181
Query: 538 KEPEEIGTVLEEQETKQN 555
K E++ ++ E K N
Sbjct: 182 KADEQMESMTYSTERKTN 199
Score = 149 bits (361), Expect = 6e-35
Identities = 77/182 (42%), Positives = 111/182 (60%), Gaps = 3/182 (1%)
Query: 967 LDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXX 1026
+D DI ++L + R +GVV QEP+LF T++ NI YG + T +E
Sbjct: 2 VDENDI-RALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDD--VTDEEMERAAREANA 58
Query: 1027 HNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAV 1086
++FI+ P + T KQR+ IARAL+R+P++L+LDEATSALD+ S+ AV
Sbjct: 59 YDFIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAV 118
Query: 1087 TEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSKQQ 1146
AL+ A+KGRT I +AHRL+TI+ AD+I L G + EKG HAEL+ +G Y+ L Q
Sbjct: 119 QAALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQ 178
Query: 1147 NV 1148
++
Sbjct: 179 DI 180
Score = 39.9 bits (89), Expect = 0.051
Identities = 15/37 (40%), Positives = 27/37 (72%)
Query: 627 VSDWQLLKLNTPEWLYLTVGSIAAFIQGACFPVFALL 663
VS ++LKLN PEW ++ +G++A+ + G PVF+++
Sbjct: 231 VSLLKILKLNKPEWPFVVLGTLASVLNGTVHPVFSII 267
>BC104894-1|AAI04895.2| 812|Homo sapiens ATP-binding cassette,
sub-family B (MDR/TAP), member 5 protein.
Length = 812
Score = 346 bits (851), Expect = 2e-94
Identities = 181/479 (37%), Positives = 273/479 (56%), Gaps = 2/479 (0%)
Query: 670 EIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTL 729
+I +FD + N+ G + L+ D A++QGATG RIG++ Q +++ + I++ Y W++T
Sbjct: 335 DIAWFDEKENSTGGLTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTF 394
Query: 730 VSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFITR 789
+ + P++ + +E +++ ++ A IATEA+ +I+T+ SL E F
Sbjct: 395 LILSIAPVLAVTGMIETAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQM 454
Query: 790 FQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXX 849
+++ L KK++ G +Y + +GA L+ G
Sbjct: 455 YEEMLQTQHRNTSKKAQIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIVFT 514
Query: 850 XXMYGAYMLGQSLVYAPSFNSAKTCGARILSIINREPRIRTVDGLNDKQDWSASGNFSIN 909
YGA +G++LV AP ++ AK+ A + +++ ++P I + K D + GN
Sbjct: 515 AIAYGAMAIGETLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPD-TCEGNLEFR 573
Query: 910 DVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDG 969
+V F YP R IL+G+ L +E GKTVA VGSSGCGKST +QL+QR YDP G + DG
Sbjct: 574 EVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDG 633
Query: 970 VDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNF 1029
VD K L + LR Q+ +V QEP+LF+ ++AENIAYGDNSR +DE H+F
Sbjct: 634 VD-AKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSF 692
Query: 1030 IVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEA 1089
I LP+ Y T KQR+ IARAL++ P++LLLDEATSALD +SE+ V A
Sbjct: 693 IEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHA 752
Query: 1090 LDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSKQQNV 1148
LD A GRTC+ + HRL+ I++AD+I VL GKI E+G H EL+ + Y++L Q+V
Sbjct: 753 LDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVNAQSV 811
Score = 341 bits (838), Expect = 9e-93
Identities = 196/528 (37%), Positives = 297/528 (56%), Gaps = 15/528 (2%)
Query: 13 IGAFVSIIFSILCNV-LSVALVSWSALKQITT--IRKLFLTAVLRQDMTWFDT--DSDFN 67
I + + +I ++C V + + + +I T +R L A+L QD+ WFD +S
Sbjct: 289 IYSMIFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGG 348
Query: 68 LASKMSENLMKLKEGMGEKLAVVSNLVGTSIICLCTAFPLGWKLALACITVMPFSIMASV 127
L + ++ ++ +++ G ++ V++ + + +F GW++ +++ P + +
Sbjct: 349 LTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGM 408
Query: 128 ALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAFGGENIEVQRYKSLLEPAEISGSR 187
T T + ++ + AGK A E L++++T+V+ E Q Y+ +L+ + S+
Sbjct: 409 IETAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTSK 468
Query: 188 RGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDANKPDDERTYIIGIVLSITFSVYMAT 247
+ G F+ Y GF +G LI A + E +I+ +I +
Sbjct: 469 KAQIIGSCYAFSHAFIYFAYAAGFRFGAYLI--QAGRMTPEGMFIV--FTAIAYGAMAIG 524
Query: 248 QSITLCVPHMEVFATARGAAASIFSLLDKHPKIDCLSEAGSSPRRVIGEISLEDVHFSYP 307
+++ L P ++ A+ AA +F+LL+K P ID S+ G P G + +V F YP
Sbjct: 525 ETLVLA-PE---YSKAKSGAAHLFALLEKKPNIDSRSQEGKKPDTCEGNLEFREVSFFYP 580
Query: 308 SRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLN 367
R D+ IL+G SL I+ G++VA VGSSGCGKST +QLLQRLYDP QG V DG + K LN
Sbjct: 581 CRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELN 640
Query: 368 IGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPE--ATSEDVYRVAEMAYAHEFIKNLPNGY 425
+ WLRS + +V QEPVLF +I +NIA G +++ A A H FI+ LP Y
Sbjct: 641 VQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKY 700
Query: 426 ETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGR 485
T +G +GA LSGGQKQR+AIAR+LL++P +LLLDEATSALD SEK VQ ALD+A GR
Sbjct: 701 NTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGR 760
Query: 486 TTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTS 533
T L V+HRLS I N I+ + G I EQGTH EL++ + Y KLV +
Sbjct: 761 TCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVNA 808
Score = 193 bits (470), Expect = 4e-48
Identities = 95/198 (47%), Positives = 132/198 (66%)
Query: 358 LDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEF 417
+D +++ LN+ R +GVV QEPVLF TI +NI G + T E++ R A A A++F
Sbjct: 2 VDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDF 61
Query: 418 IKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAA 477
I PN + T++GE+GA +SGGQKQRIAIAR+L+R P +L+LDEATSALD S+ VQAA
Sbjct: 62 IMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAA 121
Query: 478 LDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSGKET 537
L++AS GRTT+ V+HRLSTI + I+ + G + E+G H ELM +G Y+ LV S
Sbjct: 122 LEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQDIK 181
Query: 538 KEPEEIGTVLEEQETKQN 555
K E++ ++ E K N
Sbjct: 182 KADEQMESMTYSTERKTN 199
Score = 149 bits (361), Expect = 6e-35
Identities = 77/182 (42%), Positives = 111/182 (60%), Gaps = 3/182 (1%)
Query: 967 LDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXX 1026
+D DI ++L + R +GVV QEP+LF T++ NI YG + T +E
Sbjct: 2 VDENDI-RALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDD--VTDEEMERAAREANA 58
Query: 1027 HNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAV 1086
++FI+ P + T KQR+ IARAL+R+P++L+LDEATSALD+ S+ AV
Sbjct: 59 YDFIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAV 118
Query: 1087 TEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSKQQ 1146
AL+ A+KGRT I +AHRL+TI+ AD+I L G + EKG HAEL+ +G Y+ L Q
Sbjct: 119 QAALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQ 178
Query: 1147 NV 1148
++
Sbjct: 179 DI 180
Score = 39.9 bits (89), Expect = 0.051
Identities = 15/37 (40%), Positives = 27/37 (72%)
Query: 627 VSDWQLLKLNTPEWLYLTVGSIAAFIQGACFPVFALL 663
VS ++LKLN PEW ++ +G++A+ + G PVF+++
Sbjct: 231 VSLLKILKLNKPEWPFVVLGTLASVLNGTVHPVFSII 267
>AY234788-1|AAO73470.1| 812|Homo sapiens P-glycoprotein ABCB5
protein.
Length = 812
Score = 346 bits (850), Expect = 3e-94
Identities = 181/479 (37%), Positives = 273/479 (56%), Gaps = 2/479 (0%)
Query: 670 EIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTL 729
+I +FD + N+ G + L+ D A++QGATG RIG++ Q +++ + I++ Y W++T
Sbjct: 335 DIAWFDEKENSTGGLTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTF 394
Query: 730 VSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFITR 789
+ + P++ + +E +++ ++ A IATEA+ +I+T+ SL E F
Sbjct: 395 LILSIAPVLAVTGMIETAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQM 454
Query: 790 FQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXX 849
+++ L KK++ G +Y + +GA L+ G
Sbjct: 455 YEEMLQTQHRNTSKKAQIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIVFT 514
Query: 850 XXMYGAYMLGQSLVYAPSFNSAKTCGARILSIINREPRIRTVDGLNDKQDWSASGNFSIN 909
YGA +G++LV AP ++ AK+ A + +++ ++P I + K D + GN
Sbjct: 515 AIAYGAMAIGKTLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPD-TCEGNLEFR 573
Query: 910 DVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDG 969
+V F YP R IL+G+ L +E GKTVA VGSSGCGKST +QL+QR YDP G + DG
Sbjct: 574 EVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDG 633
Query: 970 VDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNF 1029
VD K L + LR Q+ +V QEP+LF+ ++AENIAYGDNSR +DE H+F
Sbjct: 634 VD-AKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSF 692
Query: 1030 IVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEA 1089
I LP+ Y T KQR+ IARAL++ P++LLLDEATSALD +SE+ V A
Sbjct: 693 IEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHA 752
Query: 1090 LDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSKQQNV 1148
LD A GRTC+ + HRL+ I++AD+I VL GKI E+G H EL+ + Y++L Q+V
Sbjct: 753 LDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVNAQSV 811
Score = 341 bits (838), Expect = 9e-93
Identities = 197/528 (37%), Positives = 296/528 (56%), Gaps = 15/528 (2%)
Query: 13 IGAFVSIIFSILCNV-LSVALVSWSALKQITT--IRKLFLTAVLRQDMTWFDT--DSDFN 67
I + + +I ++C V + + + +I T +R L A+L QD+ WFD +S
Sbjct: 289 IYSMIFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGG 348
Query: 68 LASKMSENLMKLKEGMGEKLAVVSNLVGTSIICLCTAFPLGWKLALACITVMPFSIMASV 127
L + ++ ++ +++ G ++ V++ + + +F GW++ +++ P + +
Sbjct: 349 LTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGM 408
Query: 128 ALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAFGGENIEVQRYKSLLEPAEISGSR 187
T T + ++ + AGK A E L++++T+V+ E Q Y+ +L+ + S+
Sbjct: 409 IETAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTSK 468
Query: 188 RGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDANKPDDERTYIIGIVLSITFSVYMAT 247
+ G F+ Y GF +G LI A + E +I+ +I + MA
Sbjct: 469 KAQIIGSCYAFSHAFIYFAYAAGFRFGAYLI--QAGRMTPEGMFIV--FTAIAYGA-MAI 523
Query: 248 QSITLCVPHMEVFATARGAAASIFSLLDKHPKIDCLSEAGSSPRRVIGEISLEDVHFSYP 307
+ P ++ A+ AA +F+LL+K P ID S+ G P G + +V F YP
Sbjct: 524 GKTLVLAPE---YSKAKSGAAHLFALLEKKPNIDSRSQEGKKPDTCEGNLEFREVSFFYP 580
Query: 308 SRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLN 367
R D+ IL+G SL I+ G++VA VGSSGCGKST +QLLQRLYDP QG V DG + K LN
Sbjct: 581 CRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELN 640
Query: 368 IGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPE--ATSEDVYRVAEMAYAHEFIKNLPNGY 425
+ WLRS + +V QEPVLF +I +NIA G +++ A A H FI+ LP Y
Sbjct: 641 VQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKY 700
Query: 426 ETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGR 485
T +G +GA LSGGQKQR+AIAR+LL++P +LLLDEATSALD SEK VQ ALD+A GR
Sbjct: 701 NTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGR 760
Query: 486 TTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTS 533
T L V+HRLS I N I+ + G I EQGTH EL++ + Y KLV +
Sbjct: 761 TCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVNA 808
Score = 193 bits (470), Expect = 4e-48
Identities = 95/198 (47%), Positives = 132/198 (66%)
Query: 358 LDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEF 417
+D +++ LN+ R +GVV QEPVLF TI +NI G + T E++ R A A A++F
Sbjct: 2 VDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDF 61
Query: 418 IKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAA 477
I PN + T++GE+GA +SGGQKQRIAIAR+L+R P +L+LDEATSALD S+ VQAA
Sbjct: 62 IMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAA 121
Query: 478 LDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSGKET 537
L++AS GRTT+ V+HRLSTI + I+ + G + E+G H ELM +G Y+ LV S
Sbjct: 122 LEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQDIK 181
Query: 538 KEPEEIGTVLEEQETKQN 555
K E++ ++ E K N
Sbjct: 182 KADEQMESMTYSTERKTN 199
Score = 149 bits (361), Expect = 6e-35
Identities = 77/182 (42%), Positives = 111/182 (60%), Gaps = 3/182 (1%)
Query: 967 LDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXX 1026
+D DI ++L + R +GVV QEP+LF T++ NI YG + T +E
Sbjct: 2 VDENDI-RALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDD--VTDEEMERAAREANA 58
Query: 1027 HNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAV 1086
++FI+ P + T KQR+ IARAL+R+P++L+LDEATSALD+ S+ AV
Sbjct: 59 YDFIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAV 118
Query: 1087 TEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSKQQ 1146
AL+ A+KGRT I +AHRL+TI+ AD+I L G + EKG HAEL+ +G Y+ L Q
Sbjct: 119 QAALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQ 178
Query: 1147 NV 1148
++
Sbjct: 179 DI 180
Score = 39.9 bits (89), Expect = 0.051
Identities = 15/37 (40%), Positives = 27/37 (72%)
Query: 627 VSDWQLLKLNTPEWLYLTVGSIAAFIQGACFPVFALL 663
VS ++LKLN PEW ++ +G++A+ + G PVF+++
Sbjct: 231 VSLLKILKLNKPEWPFVVLGTLASVLNGTVHPVFSII 267
>AY090613-1|AAM09027.1| 812|Homo sapiens P-glycoprotein protein.
Length = 812
Score = 346 bits (850), Expect = 3e-94
Identities = 181/479 (37%), Positives = 273/479 (56%), Gaps = 2/479 (0%)
Query: 670 EIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTL 729
+I +FD + N+ G + L+ D A++QGATG RIG++ Q +++ + I++ Y W++T
Sbjct: 335 DIAWFDEKENSTGGLTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTF 394
Query: 730 VSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFITR 789
+ + P++ + +E +++ ++ A IATEA+ +I+T+ SL E F
Sbjct: 395 LILSIAPVLAVTGMIETAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQM 454
Query: 790 FQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXX 849
+++ L KK++ G +Y + +GA L+ G
Sbjct: 455 YEEMLQTQHRNTSKKAQIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIVFT 514
Query: 850 XXMYGAYMLGQSLVYAPSFNSAKTCGARILSIINREPRIRTVDGLNDKQDWSASGNFSIN 909
YGA +G++LV AP ++ AK+ A + +++ ++P I + K D + GN
Sbjct: 515 AIAYGAMAIGKTLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPD-TCEGNLEFR 573
Query: 910 DVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDG 969
+V F YP R IL+G+ L +E GKTVA VGSSGCGKST +QL+QR YDP G + DG
Sbjct: 574 EVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDG 633
Query: 970 VDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNF 1029
VD K L + LR Q+ +V QEP+LF+ ++AENIAYGDNSR +DE H+F
Sbjct: 634 VD-AKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSF 692
Query: 1030 IVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEA 1089
I LP+ Y T KQR+ IARAL++ P++LLLDEATSALD +SE+ V A
Sbjct: 693 IEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHA 752
Query: 1090 LDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSKQQNV 1148
LD A GRTC+ + HRL+ I++AD+I VL GKI E+G H EL+ + Y++L Q+V
Sbjct: 753 LDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVNAQSV 811
Score = 341 bits (838), Expect = 9e-93
Identities = 197/528 (37%), Positives = 296/528 (56%), Gaps = 15/528 (2%)
Query: 13 IGAFVSIIFSILCNV-LSVALVSWSALKQITT--IRKLFLTAVLRQDMTWFDT--DSDFN 67
I + + +I ++C V + + + +I T +R L A+L QD+ WFD +S
Sbjct: 289 IYSMIFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGG 348
Query: 68 LASKMSENLMKLKEGMGEKLAVVSNLVGTSIICLCTAFPLGWKLALACITVMPFSIMASV 127
L + ++ ++ +++ G ++ V++ + + +F GW++ +++ P + +
Sbjct: 349 LTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGM 408
Query: 128 ALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAFGGENIEVQRYKSLLEPAEISGSR 187
T T + ++ + AGK A E L++++T+V+ E Q Y+ +L+ + S+
Sbjct: 409 IETAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTSK 468
Query: 188 RGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDANKPDDERTYIIGIVLSITFSVYMAT 247
+ G F+ Y GF +G LI A + E +I+ +I + MA
Sbjct: 469 KAQIIGSCYAFSHAFIYFAYAAGFRFGAYLI--QAGRMTPEGMFIV--FTAIAYGA-MAI 523
Query: 248 QSITLCVPHMEVFATARGAAASIFSLLDKHPKIDCLSEAGSSPRRVIGEISLEDVHFSYP 307
+ P ++ A+ AA +F+LL+K P ID S+ G P G + +V F YP
Sbjct: 524 GKTLVLAPE---YSKAKSGAAHLFALLEKKPNIDSRSQEGKKPDTCEGNLEFREVSFFYP 580
Query: 308 SRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLN 367
R D+ IL+G SL I+ G++VA VGSSGCGKST +QLLQRLYDP QG V DG + K LN
Sbjct: 581 CRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELN 640
Query: 368 IGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPE--ATSEDVYRVAEMAYAHEFIKNLPNGY 425
+ WLRS + +V QEPVLF +I +NIA G +++ A A H FI+ LP Y
Sbjct: 641 VQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKY 700
Query: 426 ETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGR 485
T +G +GA LSGGQKQR+AIAR+LL++P +LLLDEATSALD SEK VQ ALD+A GR
Sbjct: 701 NTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGR 760
Query: 486 TTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTS 533
T L V+HRLS I N I+ + G I EQGTH EL++ + Y KLV +
Sbjct: 761 TCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVNA 808
Score = 193 bits (470), Expect = 4e-48
Identities = 95/198 (47%), Positives = 132/198 (66%)
Query: 358 LDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEF 417
+D +++ LN+ R +GVV QEPVLF TI +NI G + T E++ R A A A++F
Sbjct: 2 VDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDF 61
Query: 418 IKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAA 477
I PN + T++GE+GA +SGGQKQRIAIAR+L+R P +L+LDEATSALD S+ VQAA
Sbjct: 62 IMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAA 121
Query: 478 LDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSGKET 537
L++AS GRTT+ V+HRLSTI + I+ + G + E+G H ELM +G Y+ LV S
Sbjct: 122 LEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQDIK 181
Query: 538 KEPEEIGTVLEEQETKQN 555
K E++ ++ E K N
Sbjct: 182 KADEQMESMTYSTERKTN 199
Score = 149 bits (361), Expect = 6e-35
Identities = 77/182 (42%), Positives = 111/182 (60%), Gaps = 3/182 (1%)
Query: 967 LDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXX 1026
+D DI ++L + R +GVV QEP+LF T++ NI YG + T +E
Sbjct: 2 VDENDI-RALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDD--VTDEEMERAAREANA 58
Query: 1027 HNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAV 1086
++FI+ P + T KQR+ IARAL+R+P++L+LDEATSALD+ S+ AV
Sbjct: 59 YDFIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAV 118
Query: 1087 TEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSKQQ 1146
AL+ A+KGRT I +AHRL+TI+ AD+I L G + EKG HAEL+ +G Y+ L Q
Sbjct: 119 QAALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQ 178
Query: 1147 NV 1148
++
Sbjct: 179 DI 180
Score = 39.9 bits (89), Expect = 0.051
Identities = 15/37 (40%), Positives = 27/37 (72%)
Query: 627 VSDWQLLKLNTPEWLYLTVGSIAAFIQGACFPVFALL 663
VS ++LKLN PEW ++ +G++A+ + G PVF+++
Sbjct: 231 VSLLKILKLNKPEWPFVVLGTLASVLNGTVHPVFSII 267
>AF399931-1|AAQ03033.1| 832|Homo sapiens P-glycoprotein protein.
Length = 832
Score = 346 bits (850), Expect = 3e-94
Identities = 181/479 (37%), Positives = 273/479 (56%), Gaps = 2/479 (0%)
Query: 670 EIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTL 729
+I +FD + N+ G + L+ D A++QGATG RIG++ Q +++ + I++ Y W++T
Sbjct: 355 DIAWFDEKENSTGGLTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTF 414
Query: 730 VSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFITR 789
+ + P++ + +E +++ ++ A IATEA+ +I+T+ SL E F
Sbjct: 415 LILSIAPVLAVTGMIETAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQM 474
Query: 790 FQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXX 849
+++ L KK++ G +Y + +GA L+ G
Sbjct: 475 YEEMLQTQHRNTSKKAQIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIVFT 534
Query: 850 XXMYGAYMLGQSLVYAPSFNSAKTCGARILSIINREPRIRTVDGLNDKQDWSASGNFSIN 909
YGA +G++LV AP ++ AK+ A + +++ ++P I + K D + GN
Sbjct: 535 AIAYGAMAIGKTLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPD-TCEGNLEFR 593
Query: 910 DVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDG 969
+V F YP R IL+G+ L +E GKTVA VGSSGCGKST +QL+QR YDP G + DG
Sbjct: 594 EVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDG 653
Query: 970 VDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNF 1029
VD K L + LR Q+ +V QEP+LF+ ++AENIAYGDNSR +DE H+F
Sbjct: 654 VD-AKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSF 712
Query: 1030 IVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEA 1089
I LP+ Y T KQR+ IARAL++ P++LLLDEATSALD +SE+ V A
Sbjct: 713 IEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHA 772
Query: 1090 LDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSKQQNV 1148
LD A GRTC+ + HRL+ I++AD+I VL GKI E+G H EL+ + Y++L Q+V
Sbjct: 773 LDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVNAQSV 831
Score = 341 bits (838), Expect = 9e-93
Identities = 197/528 (37%), Positives = 296/528 (56%), Gaps = 15/528 (2%)
Query: 13 IGAFVSIIFSILCNV-LSVALVSWSALKQITT--IRKLFLTAVLRQDMTWFDT--DSDFN 67
I + + +I ++C V + + + +I T +R L A+L QD+ WFD +S
Sbjct: 309 IYSMIFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGG 368
Query: 68 LASKMSENLMKLKEGMGEKLAVVSNLVGTSIICLCTAFPLGWKLALACITVMPFSIMASV 127
L + ++ ++ +++ G ++ V++ + + +F GW++ +++ P + +
Sbjct: 369 LTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGM 428
Query: 128 ALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAFGGENIEVQRYKSLLEPAEISGSR 187
T T + ++ + AGK A E L++++T+V+ E Q Y+ +L+ + S+
Sbjct: 429 IETAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTSK 488
Query: 188 RGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDANKPDDERTYIIGIVLSITFSVYMAT 247
+ G F+ Y GF +G LI A + E +I+ +I + MA
Sbjct: 489 KAQIIGSCYAFSHAFIYFAYAAGFRFGAYLI--QAGRMTPEGMFIV--FTAIAYGA-MAI 543
Query: 248 QSITLCVPHMEVFATARGAAASIFSLLDKHPKIDCLSEAGSSPRRVIGEISLEDVHFSYP 307
+ P ++ A+ AA +F+LL+K P ID S+ G P G + +V F YP
Sbjct: 544 GKTLVLAPE---YSKAKSGAAHLFALLEKKPNIDSRSQEGKKPDTCEGNLEFREVSFFYP 600
Query: 308 SRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLN 367
R D+ IL+G SL I+ G++VA VGSSGCGKST +QLLQRLYDP QG V DG + K LN
Sbjct: 601 CRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELN 660
Query: 368 IGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPE--ATSEDVYRVAEMAYAHEFIKNLPNGY 425
+ WLRS + +V QEPVLF +I +NIA G +++ A A H FI+ LP Y
Sbjct: 661 VQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKY 720
Query: 426 ETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGR 485
T +G +GA LSGGQKQR+AIAR+LL++P +LLLDEATSALD SEK VQ ALD+A GR
Sbjct: 721 NTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGR 780
Query: 486 TTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTS 533
T L V+HRLS I N I+ + G I EQGTH EL++ + Y KLV +
Sbjct: 781 TCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVNA 828
Score = 220 bits (537), Expect = 3e-56
Identities = 107/217 (49%), Positives = 148/217 (68%)
Query: 339 STILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYP 398
ST++QLLQRLYDP+ G + +D +++ LN+ R +GVV QEPVLF TI +NI G
Sbjct: 3 STVVQLLQRLYDPDDGFIMVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRD 62
Query: 399 EATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLL 458
+ T E++ R A A A++FI PN + T++GE+GA +SGGQKQRIAIAR+L+R P +L+
Sbjct: 63 DVTDEEMERAAREANAYDFIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILI 122
Query: 459 LDEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHV 518
LDEATSALD S+ VQAAL++AS GRTT+ V+HRLSTI + I+ + G + E+G H
Sbjct: 123 LDEATSALDSESKSAVQAALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHA 182
Query: 519 ELMKAKGFYHKLVTSGKETKEPEEIGTVLEEQETKQN 555
ELM +G Y+ LV S K E++ ++ E K N
Sbjct: 183 ELMAKRGLYYSLVMSQDIKKADEQMESMTYSTERKTN 219
Score = 172 bits (419), Expect = 5e-42
Identities = 89/201 (44%), Positives = 125/201 (62%), Gaps = 3/201 (1%)
Query: 948 STVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGD 1007
STV+QL+QR YDP G I +D DI ++L + R +GVV QEP+LF T++ NI YG
Sbjct: 3 STVVQLLQRLYDPDDGFIMVDENDI-RALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGR 61
Query: 1008 NSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPR 1067
+ T +E ++FI+ P + T KQR+ IARAL+R+P+
Sbjct: 62 DD--VTDEEMERAAREANAYDFIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPK 119
Query: 1068 LLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKG 1127
+L+LDEATSALD+ S+ AV AL+ A+KGRT I +AHRL+TI+ AD+I L G + EKG
Sbjct: 120 ILILDEATSALDSESKSAVQAALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKG 179
Query: 1128 NHAELIGLKGHYWQLSKQQNV 1148
HAEL+ +G Y+ L Q++
Sbjct: 180 AHAELMAKRGLYYSLVMSQDI 200
Score = 39.9 bits (89), Expect = 0.051
Identities = 15/37 (40%), Positives = 27/37 (72%)
Query: 627 VSDWQLLKLNTPEWLYLTVGSIAAFIQGACFPVFALL 663
VS ++LKLN PEW ++ +G++A+ + G PVF+++
Sbjct: 251 VSLLKILKLNKPEWPFVVLGTLASVLNGTVHPVFSII 287
>AF319622-1|AAN76500.1| 681|Homo sapiens P-glycoprotein protein.
Length = 681
Score = 346 bits (850), Expect = 3e-94
Identities = 181/479 (37%), Positives = 273/479 (56%), Gaps = 2/479 (0%)
Query: 670 EIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTL 729
+I +FD + N+ G + L+ D A++QGATG RIG++ Q +++ + I++ Y W++T
Sbjct: 204 DIAWFDEKENSTGGLTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTF 263
Query: 730 VSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFITR 789
+ + P++ + +E +++ ++ A IATEA+ +I+T+ SL E F
Sbjct: 264 LILSIAPVLAVTGMIETAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQM 323
Query: 790 FQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXX 849
+++ L KK++ G +Y + +GA L+ G
Sbjct: 324 YEEMLQTQHRNTSKKAQIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIVFT 383
Query: 850 XXMYGAYMLGQSLVYAPSFNSAKTCGARILSIINREPRIRTVDGLNDKQDWSASGNFSIN 909
YGA +G++LV AP ++ AK+ A + +++ ++P I + K D + GN
Sbjct: 384 AIAYGAMAIGKTLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPD-TCEGNLEFR 442
Query: 910 DVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDG 969
+V F YP R IL+G+ L +E GKTVA VGSSGCGKST +QL+QR YDP G + DG
Sbjct: 443 EVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDG 502
Query: 970 VDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNF 1029
VD K L + LR Q+ +V QEP+LF+ ++AENIAYGDNSR +DE H+F
Sbjct: 503 VD-AKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSF 561
Query: 1030 IVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEA 1089
I LP+ Y T KQR+ IARAL++ P++LLLDEATSALD +SE+ V A
Sbjct: 562 IEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHA 621
Query: 1090 LDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSKQQNV 1148
LD A GRTC+ + HRL+ I++AD+I VL GKI E+G H EL+ + Y++L Q+V
Sbjct: 622 LDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVNAQSV 680
Score = 341 bits (838), Expect = 9e-93
Identities = 197/528 (37%), Positives = 296/528 (56%), Gaps = 15/528 (2%)
Query: 13 IGAFVSIIFSILCNV-LSVALVSWSALKQITT--IRKLFLTAVLRQDMTWFDT--DSDFN 67
I + + +I ++C V + + + +I T +R L A+L QD+ WFD +S
Sbjct: 158 IYSMIFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGG 217
Query: 68 LASKMSENLMKLKEGMGEKLAVVSNLVGTSIICLCTAFPLGWKLALACITVMPFSIMASV 127
L + ++ ++ +++ G ++ V++ + + +F GW++ +++ P + +
Sbjct: 218 LTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGM 277
Query: 128 ALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAFGGENIEVQRYKSLLEPAEISGSR 187
T T + ++ + AGK A E L++++T+V+ E Q Y+ +L+ + S+
Sbjct: 278 IETAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTSK 337
Query: 188 RGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDANKPDDERTYIIGIVLSITFSVYMAT 247
+ G F+ Y GF +G LI A + E +I+ +I + MA
Sbjct: 338 KAQIIGSCYAFSHAFIYFAYAAGFRFGAYLI--QAGRMTPEGMFIV--FTAIAYGA-MAI 392
Query: 248 QSITLCVPHMEVFATARGAAASIFSLLDKHPKIDCLSEAGSSPRRVIGEISLEDVHFSYP 307
+ P ++ A+ AA +F+LL+K P ID S+ G P G + +V F YP
Sbjct: 393 GKTLVLAPE---YSKAKSGAAHLFALLEKKPNIDSRSQEGKKPDTCEGNLEFREVSFFYP 449
Query: 308 SRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLN 367
R D+ IL+G SL I+ G++VA VGSSGCGKST +QLLQRLYDP QG V DG + K LN
Sbjct: 450 CRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELN 509
Query: 368 IGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPE--ATSEDVYRVAEMAYAHEFIKNLPNGY 425
+ WLRS + +V QEPVLF +I +NIA G +++ A A H FI+ LP Y
Sbjct: 510 VQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKY 569
Query: 426 ETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGR 485
T +G +GA LSGGQKQR+AIAR+LL++P +LLLDEATSALD SEK VQ ALD+A GR
Sbjct: 570 NTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGR 629
Query: 486 TTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTS 533
T L V+HRLS I N I+ + G I EQGTH EL++ + Y KLV +
Sbjct: 630 TCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVNA 677
Score = 52.0 bits (119), Expect = 1e-05
Identities = 25/68 (36%), Positives = 38/68 (55%)
Query: 488 LTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSGKETKEPEEIGTVL 547
+ V+HRLSTI + I+ + G + E+G H ELM +G Y+ LV S K E++ ++
Sbjct: 1 MVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQDIKKADEQMESMT 60
Query: 548 EEQETKQN 555
E K N
Sbjct: 61 YSTERKTN 68
Score = 52.0 bits (119), Expect = 1e-05
Identities = 22/49 (44%), Positives = 33/49 (67%)
Query: 1100 ITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSKQQNV 1148
+ +AHRL+TI+ AD+I L G + EKG HAEL+ +G Y+ L Q++
Sbjct: 1 MVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQDI 49
Score = 39.9 bits (89), Expect = 0.051
Identities = 15/37 (40%), Positives = 27/37 (72%)
Query: 627 VSDWQLLKLNTPEWLYLTVGSIAAFIQGACFPVFALL 663
VS ++LKLN PEW ++ +G++A+ + G PVF+++
Sbjct: 100 VSLLKILKLNKPEWPFVVLGTLASVLNGTVHPVFSII 136
>AY851365-1|AAW31630.1| 812|Homo sapiens ABCB5beta protein.
Length = 812
Score = 343 bits (843), Expect = 2e-93
Identities = 180/479 (37%), Positives = 272/479 (56%), Gaps = 2/479 (0%)
Query: 670 EIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTL 729
+I +FD + N+ G + L+ D A++QGATG RIG++ Q +++ + I++ Y W++T
Sbjct: 335 DIAWFDEKENSTGGLTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTF 394
Query: 730 VSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFITR 789
+ + P++ + +E +++ ++ A IATEA+ +I+T+ SL E F
Sbjct: 395 LILSIAPVLAVTGMIETAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQM 454
Query: 790 FQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXX 849
+++ L KK++ G +Y + +GA L+ G
Sbjct: 455 YEEMLQTQHRNTSKKAQIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIVFT 514
Query: 850 XXMYGAYMLGQSLVYAPSFNSAKTCGARILSIINREPRIRTVDGLNDKQDWSASGNFSIN 909
YGA +G++LV AP ++ AK+ A + +++ ++P I + K D + GN
Sbjct: 515 AIAYGAMAIGKTLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPD-TCEGNLEFR 573
Query: 910 DVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDG 969
+V F YP R IL+G+ L +E GKTVA VGSSGCGKST +QL+QR YDP G + DG
Sbjct: 574 EVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDG 633
Query: 970 VDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNF 1029
VD K L + LR Q+ +V QEP+LF+ ++AENIAYGDNSR +DE H+F
Sbjct: 634 VD-AKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSF 692
Query: 1030 IVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEA 1089
I P+ Y T KQR+ IARAL++ P++LLLDEATSALD +SE+ V A
Sbjct: 693 IEGPPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHA 752
Query: 1090 LDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSKQQNV 1148
LD A GRTC+ + HRL+ I++AD+I VL GKI E+G H EL+ + Y++L Q+V
Sbjct: 753 LDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVNAQSV 811
Score = 338 bits (831), Expect = 6e-92
Identities = 196/528 (37%), Positives = 295/528 (55%), Gaps = 15/528 (2%)
Query: 13 IGAFVSIIFSILCNV-LSVALVSWSALKQITT--IRKLFLTAVLRQDMTWFDT--DSDFN 67
I + + +I ++C V + + + +I T +R L A+L QD+ WFD +S
Sbjct: 289 IYSMIFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGG 348
Query: 68 LASKMSENLMKLKEGMGEKLAVVSNLVGTSIICLCTAFPLGWKLALACITVMPFSIMASV 127
L + ++ ++ +++ G ++ V++ + + +F GW++ +++ P + +
Sbjct: 349 LTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGM 408
Query: 128 ALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAFGGENIEVQRYKSLLEPAEISGSR 187
T T + ++ + AGK A E L++++T+V+ E Q Y+ +L+ + S+
Sbjct: 409 IETAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTSK 468
Query: 188 RGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDANKPDDERTYIIGIVLSITFSVYMAT 247
+ G F+ Y GF +G LI A + E +I+ +I + MA
Sbjct: 469 KAQIIGSCYAFSHAFIYFAYAAGFRFGAYLI--QAGRMTPEGMFIV--FTAIAYGA-MAI 523
Query: 248 QSITLCVPHMEVFATARGAAASIFSLLDKHPKIDCLSEAGSSPRRVIGEISLEDVHFSYP 307
+ P ++ A+ AA +F+LL+K P ID S+ G P G + +V F YP
Sbjct: 524 GKTLVLAPE---YSKAKSGAAHLFALLEKKPNIDSRSQEGKKPDTCEGNLEFREVSFFYP 580
Query: 308 SRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLN 367
R D+ IL+G SL I+ G++VA VGSSGCGKST +QLLQRLYDP QG V DG + K LN
Sbjct: 581 CRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELN 640
Query: 368 IGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPE--ATSEDVYRVAEMAYAHEFIKNLPNGY 425
+ WLRS + +V QEPVLF +I +NIA G +++ A A H FI+ P Y
Sbjct: 641 VQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGPPEKY 700
Query: 426 ETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGR 485
T +G +GA LSGGQKQR+AIAR+LL++P +LLLDEATSALD SEK VQ ALD+A GR
Sbjct: 701 NTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGR 760
Query: 486 TTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTS 533
T L V+HRLS I N I+ + G I EQGTH EL++ + Y KLV +
Sbjct: 761 TCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVNA 808
Score = 194 bits (474), Expect = 1e-48
Identities = 96/198 (48%), Positives = 132/198 (66%)
Query: 358 LDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEF 417
+D +++ LN+ R +GVV QEPVLF TI +NI G + T E++ R A A A++F
Sbjct: 2 VDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDF 61
Query: 418 IKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAA 477
I PN + T++GE+GA +SGGQKQRIAIAR+L+R P +L+LDEATSALD SE VQAA
Sbjct: 62 IMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESESAVQAA 121
Query: 478 LDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSGKET 537
L++AS GRTT+ V+HRLSTI + I+ + G + E+G H ELM +G Y+ LV S
Sbjct: 122 LEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQDIK 181
Query: 538 KEPEEIGTVLEEQETKQN 555
K E++ ++ E K N
Sbjct: 182 KADEQMESMTYSTERKTN 199
Score = 151 bits (365), Expect = 2e-35
Identities = 78/182 (42%), Positives = 111/182 (60%), Gaps = 3/182 (1%)
Query: 967 LDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXX 1026
+D DI ++L + R +GVV QEP+LF T++ NI YG + T +E
Sbjct: 2 VDENDI-RALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDD--VTDEEMERAAREANA 58
Query: 1027 HNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAV 1086
++FI+ P + T KQR+ IARAL+R+P++L+LDEATSALD+ SE AV
Sbjct: 59 YDFIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESESAV 118
Query: 1087 TEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSKQQ 1146
AL+ A+KGRT I +AHRL+TI+ AD+I L G + EKG HAEL+ +G Y+ L Q
Sbjct: 119 QAALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQ 178
Query: 1147 NV 1148
++
Sbjct: 179 DI 180
Score = 39.9 bits (89), Expect = 0.051
Identities = 15/37 (40%), Positives = 27/37 (72%)
Query: 627 VSDWQLLKLNTPEWLYLTVGSIAAFIQGACFPVFALL 663
VS ++LKLN PEW ++ +G++A+ + G PVF+++
Sbjct: 231 VSLLKILKLNKPEWPFVVLGTLASVLNGTVHPVFSII 267
>AC069137-4|AAY24100.1| 451|Homo sapiens unknown protein.
Length = 451
Score = 332 bits (817), Expect = 3e-90
Identities = 167/445 (37%), Positives = 257/445 (57%), Gaps = 2/445 (0%)
Query: 698 ATGLRIGLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGSIWLEGIMSQKSQQDER 757
A G +IG+I+ F++VTV I+A S++WKL+LV F P + S + M ++
Sbjct: 1 AAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLALSGATQTRMLTGFASRDK 60
Query: 758 EAMESATAIATEAVVSIKTVQSLGIESLFITRFQDALIDACAAVVKKSRWRGLVLGLCIY 817
+A+E I EA+ +I+TV +G E FI + L ++K+ G
Sbjct: 61 QALEMVGQITNEALSNIRTVAGIGKERRFIEALETELEKPFKTAIQKANIYGFCFAFAQC 120
Query: 818 VPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXXXXMYGAYMLGQSLVYAPSFNSAKTCGAR 877
+ ++ ++ YG L+++ + A LG++ Y PS+ AK AR
Sbjct: 121 IMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRAFSYTPSYAKAKISAAR 180
Query: 878 ILSIINREPRIRTVDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTV 937
+++R+P I + +K D + G D +F+YP+R +L G+ + + G+T+
Sbjct: 181 FFQLLDRQPPISVYNTAGEKWD-NFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTL 239
Query: 938 ALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDR 997
A VGSSGCGKST +QL++RFYDP G + +DG D +K + + LR +G+V QEP+LF
Sbjct: 240 AFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHD-SKKVNVQFLRSNIGIVSQEPVLFAC 298
Query: 998 TLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVC 1057
++ +NI YGDN+++ M+ H+F++SLP+ YETN KQR+
Sbjct: 299 SIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIA 358
Query: 1058 IARALIRSPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICV 1117
IARA++R P++LLLDEATSALD SE+ V ALD A +GRTCI IAHRL+TI++ADII V
Sbjct: 359 IARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIAV 418
Query: 1118 LDKGKIVEKGNHAELIGLKGHYWQL 1142
+ +G ++EKG H EL+ KG Y++L
Sbjct: 419 MAQGVVIEKGTHEELMAQKGAYYKL 443
Score = 332 bits (816), Expect = 4e-90
Identities = 176/453 (38%), Positives = 262/453 (57%), Gaps = 10/453 (2%)
Query: 84 GEKLAVVSNLVGTSIICLCTAFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMES 143
G ++ ++ N + + AF WKL+L + PF ++ T T + R+ ++
Sbjct: 3 GSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLALSGATQTRMLTGFASRDKQA 62
Query: 144 YSQAGKQAEEVLKSVKTVVAFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLT 203
G+ E L +++TV G E ++ ++ LE + ++ G F +
Sbjct: 63 LEMVGQITNEALSNIRTVAGIGKERRFIEALETELEKPFKTAIQKANIYGFCFAFAQCIM 122
Query: 204 YSLNTIGFMYGTRLIIEDANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATA 263
+ N+ + YG LI + +Y+ ++ ++ S ++ + + +A A
Sbjct: 123 FIANSASYRYGGYLISNEGL----HFSYVFRVISAVVLSATALGRAFS----YTPSYAKA 174
Query: 264 RGAAASIFSLLDKHPKIDCLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIK 323
+ +AA F LLD+ P I + AG G+I D F+YPSR D ++L G S+ I
Sbjct: 175 KISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSIS 234
Query: 324 PGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPV 383
PG+++A VGSSGCGKST +QLL+R YDP+QG V +DG + K +N+ +LRS++G+V QEPV
Sbjct: 235 PGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPV 294
Query: 384 LFRGTIYDNIAIG--YPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQK 441
LF +I DNI G E E V A+ A H+F+ +LP YET +G +G+ LS G+K
Sbjct: 295 LFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEK 354
Query: 442 QRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCH 501
QRIAIAR+++R+P +LLLDEATSALD SEK VQ ALD+A GRT + ++HRLSTI N
Sbjct: 355 QRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNAD 414
Query: 502 RIICMDQGTIIEQGTHVELMKAKGFYHKLVTSG 534
I M QG +IE+GTH ELM KG Y+KLVT+G
Sbjct: 415 IIAVMAQGVVIEKGTHEELMAQKGAYYKLVTTG 447
>AK094636-1|BAC04392.1| 701|Homo sapiens protein ( Homo sapiens
cDNA FLJ37317 fis, clone BRAMY2017455, highly similar to
Homo sapiens ATP-binding cassette protein M-ABC1 mRNA.
).
Length = 701
Score = 319 bits (783), Expect = 4e-86
Identities = 197/510 (38%), Positives = 283/510 (55%), Gaps = 23/510 (4%)
Query: 30 VALVSWSALKQITTIRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAV 89
+ L+S + +R+ +++LRQD+T+FD + L S+++ ++ + K KL +
Sbjct: 179 LVLLSHVGERMAVDMRRALFSSLLRQDITFFDANKTGQLVSRLTTDVQEFKSSF--KLVI 236
Query: 90 VSNLVGTSII--CLCTAFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQA 147
L + + CL + L +L L + P + + + K S + E ++A
Sbjct: 237 SQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARA 296
Query: 148 GKQAEEVLKSVKTVVAFGGENIEVQRYKSLLEP----AEISGSRRGLFTGLGN-GFNWVL 202
A+E L +V+TV AF E E +RY + LE AE G LF GL N FN ++
Sbjct: 297 MGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIALFQGLSNIAFNCMV 356
Query: 203 TYSLNTIGFMYGTRLIIEDANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFAT 262
+L T G L+ D ++++ S T MA S+
Sbjct: 357 LGTLFT-----GGSLVAGQQLTGGDLMSFLVA---SQTVQRSMANLSVLF-----GQVVR 403
Query: 263 ARGAAASIFSLLDKHPKIDCLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHI 322
A A +F + +P I ++ G ++ ++V FSYP R ++LK F+L +
Sbjct: 404 GLSAGARVFEYMALNPCIPLSGGCCVPKEQLRGSVTFQNVCFSYPCRPGFEVLKDFTLTL 463
Query: 323 KPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSL-GVVGQE 381
PG+ VALVG SG GK+T+ LL+R YDP G V LDGR+L+TL+ WLR + G + QE
Sbjct: 464 PPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQE 523
Query: 382 PVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQK 441
PVLF TI +NI G EA+ E+VY A A AHEFI + P GY TV+GERG +LSGGQK
Sbjct: 524 PVLFGTTIMENIRFGKLEASDEEVYTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQK 583
Query: 442 QRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCH 501
QR+AIAR+L+++P VL+LDEATSALD SE+ VQ ALDRAS GRT L ++HRLST+ H
Sbjct: 584 QRLAIARALIKQPTVLILDEATSALDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAH 643
Query: 502 RIICMDQGTIIEQGTHVELMKAKGFYHKLV 531
I+ M G + E GTH EL+K G Y +L+
Sbjct: 644 CIVVMADGRVWEAGTHEELLKKGGLYAELI 673
Score = 231 bits (564), Expect = 1e-59
Identities = 161/488 (32%), Positives = 239/488 (48%), Gaps = 9/488 (1%)
Query: 661 ALLLGYTSGEIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMA 720
AL +I +FD +N G + +RL+ D E + + L I L+ + V +
Sbjct: 196 ALFSSLLRQDITFFD--ANKTGQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSL 253
Query: 721 MSYNWKLTLVSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSL 780
+ +LTL+ P ++G L G +K + +E + A +A EA+ +++TV++
Sbjct: 254 SMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAF 313
Query: 781 GIESLFITRFQDALIDACAAVVKK-SRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXX 839
+E R+ A ++AC ++ R L GL + G LVA
Sbjct: 314 AMEQREEERY-GAELEACRCRAEELGRGIALFQGLSNIAFNCMVLGTLFTGGSLVAGQQL 372
Query: 840 XXXXXXXXXXXXMYGAYMLGQSLVYAPSFNSAKTCGARILSIINREPRIRTVDGLNDKQD 899
+ V + GAR+ + P I G ++
Sbjct: 373 TGGDLMSFLVASQTVQRSMANLSVLFGQVVRGLSAGARVFEYMALNPCIPLSGGCCVPKE 432
Query: 900 WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYD 959
G+ + +V FSYP R +LK L + GK VALVG SG GK+TV L++RFYD
Sbjct: 433 -QLRGSVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYD 491
Query: 960 PTTGNIELDGVDITKSLTLNRLRKQL-GVVQQEPILFDRTLAENIAYGDNSRKPTMDEXX 1018
PT G + LDG D+ ++L + LR Q+ G + QEP+LF T+ ENI +G + + +E
Sbjct: 492 PTAGVVMLDGRDL-RTLDPSWLRGQVVGFISQEPVLFGTTIMENIRFG--KLEASDEEVY 548
Query: 1019 XXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSAL 1078
H FI S P+GY T KQR+ IARALI+ P +L+LDEATSAL
Sbjct: 549 TAAREANAHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSAL 608
Query: 1079 DANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGH 1138
DA SER V EALD A+ GRT + IAHRL+T++ A I V+ G++ E G H EL+ G
Sbjct: 609 DAESERVVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGL 668
Query: 1139 YWQLSKQQ 1146
Y +L ++Q
Sbjct: 669 YAELIRRQ 676
>BC141814-1|AAI41815.1| 718|Homo sapiens ATP-binding cassette,
sub-family B (MDR/TAP), member 8 protein.
Length = 718
Score = 318 bits (782), Expect = 6e-86
Identities = 194/510 (38%), Positives = 283/510 (55%), Gaps = 23/510 (4%)
Query: 30 VALVSWSALKQITTIRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAV 89
+ L+S + +R+ +++LRQD+T+FD + L S+++ ++ + K KL +
Sbjct: 196 LVLLSHVGERMAVDMRRALFSSLLRQDITFFDANKTGQLVSRLTTDVQEFKSSF--KLVI 253
Query: 90 VSNLVGTSII--CLCTAFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQA 147
L + + CL + L +L L + P + + + K S + E ++A
Sbjct: 254 SQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARA 313
Query: 148 GKQAEEVLKSVKTVVAFGGENIEVQRYKSLLEP----AEISGSRRGLFTGLGNGFNWVLT 203
A+E L +V+TV AF E E +RY + LE AE G LF GL N +
Sbjct: 314 MGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIALFQGLSN-----IA 368
Query: 204 YSLNTIGFMY-GTRLIIEDANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFAT 262
++ +G ++ G L+ D ++++ S T MA S+
Sbjct: 369 FNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVA---SQTVQRSMANLSVLF-----GQVVR 420
Query: 263 ARGAAASIFSLLDKHPKIDCLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHI 322
A A +F + +P I ++ G ++ ++V FSYP R ++LK F+L +
Sbjct: 421 GLSAGARVFEYMALNPCIPLSGGCCVPKEQLRGSVTFQNVCFSYPCRPGFEVLKDFTLTL 480
Query: 323 KPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSL-GVVGQE 381
PG+ VALVG SG GK+T+ LL+R YDP G V LDGR+L+TL+ WLR + G + QE
Sbjct: 481 PPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQE 540
Query: 382 PVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQK 441
PVLF TI +NI G EA+ E+VY A A AHEFI + P GY TV+GERG +LSGGQK
Sbjct: 541 PVLFGTTIMENIRFGKLEASDEEVYTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQK 600
Query: 442 QRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCH 501
QR+AIAR+L+++P VL+LDEATSALD SE+ VQ ALDRAS GRT L ++HRLST+ H
Sbjct: 601 QRLAIARALIKQPTVLILDEATSALDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAH 660
Query: 502 RIICMDQGTIIEQGTHVELMKAKGFYHKLV 531
I+ M G + E GTH EL+K G Y +L+
Sbjct: 661 CIVVMADGRVWEAGTHEELLKKGGLYAELI 690
Score = 231 bits (565), Expect = 1e-59
Identities = 161/488 (32%), Positives = 239/488 (48%), Gaps = 9/488 (1%)
Query: 661 ALLLGYTSGEIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMA 720
AL +I +FD +N G + +RL+ D E + + L I L+ + V +
Sbjct: 213 ALFSSLLRQDITFFD--ANKTGQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSL 270
Query: 721 MSYNWKLTLVSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSL 780
+ +LTL+ P ++G L G +K + +E + A +A EA+ +++TV++
Sbjct: 271 SMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAF 330
Query: 781 GIESLFITRFQDALIDACAAVVKK-SRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXX 839
+E R+ A ++AC ++ R L GL + G LVA
Sbjct: 331 AMEQREEERY-GAELEACRCRAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQL 389
Query: 840 XXXXXXXXXXXXMYGAYMLGQSLVYAPSFNSAKTCGARILSIINREPRIRTVDGLNDKQD 899
+ V + GAR+ + P I G ++
Sbjct: 390 TGGDLMSFLVASQTVQRSMANLSVLFGQVVRGLSAGARVFEYMALNPCIPLSGGCCVPKE 449
Query: 900 WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYD 959
G+ + +V FSYP R +LK L + GK VALVG SG GK+TV L++RFYD
Sbjct: 450 -QLRGSVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYD 508
Query: 960 PTTGNIELDGVDITKSLTLNRLRKQL-GVVQQEPILFDRTLAENIAYGDNSRKPTMDEXX 1018
PT G + LDG D+ ++L + LR Q+ G + QEP+LF T+ ENI +G + + +E
Sbjct: 509 PTAGVVMLDGRDL-RTLDPSWLRGQVVGFISQEPVLFGTTIMENIRFG--KLEASDEEVY 565
Query: 1019 XXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSAL 1078
H FI S P+GY T KQR+ IARALI+ P +L+LDEATSAL
Sbjct: 566 TAAREANAHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSAL 625
Query: 1079 DANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGH 1138
DA SER V EALD A+ GRT + IAHRL+T++ A I V+ G++ E G H EL+ G
Sbjct: 626 DAESERVVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGL 685
Query: 1139 YWQLSKQQ 1146
Y +L ++Q
Sbjct: 686 YAELIRRQ 693
>AK222911-1|BAD96631.1| 718|Homo sapiens ATP-binding cassette,
sub-family B, member 8 variant protein.
Length = 718
Score = 318 bits (782), Expect = 6e-86
Identities = 194/510 (38%), Positives = 283/510 (55%), Gaps = 23/510 (4%)
Query: 30 VALVSWSALKQITTIRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAV 89
+ L+S + +R+ +++LRQD+T+FD + L S+++ ++ + K KL +
Sbjct: 196 LVLLSHVGERMAVDMRRALFSSLLRQDITFFDANKTGQLVSRLTTDVQEFKSSF--KLVI 253
Query: 90 VSNLVGTSII--CLCTAFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQA 147
L + + CL + L +L L + P + + + K S + E ++A
Sbjct: 254 SQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARA 313
Query: 148 GKQAEEVLKSVKTVVAFGGENIEVQRYKSLLEP----AEISGSRRGLFTGLGNGFNWVLT 203
A+E L +V+TV AF E E +RY + LE AE G LF GL N +
Sbjct: 314 MGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIALFQGLSN-----IA 368
Query: 204 YSLNTIGFMY-GTRLIIEDANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFAT 262
++ +G ++ G L+ D ++++ S T MA S+
Sbjct: 369 FNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVA---SQTVQRSMANLSVLF-----GQVVR 420
Query: 263 ARGAAASIFSLLDKHPKIDCLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHI 322
A A +F + +P I ++ G ++ ++V FSYP R ++LK F+L +
Sbjct: 421 GLSAGARVFEYMALNPCIPLSGGCCVPKEQLRGSVTFQNVCFSYPCRPGFEVLKDFTLTL 480
Query: 323 KPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSL-GVVGQE 381
PG+ VALVG SG GK+T+ LL+R YDP G V LDGR+L+TL+ WLR + G + QE
Sbjct: 481 PPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQE 540
Query: 382 PVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQK 441
PVLF TI +NI G EA+ E+VY A A AHEFI + P GY TV+GERG +LSGGQK
Sbjct: 541 PVLFGTTIMENIRFGKLEASDEEVYTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQK 600
Query: 442 QRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCH 501
QR+AIAR+L+++P VL+LDEATSALD SE+ VQ ALDRAS GRT L ++HRLST+ H
Sbjct: 601 QRLAIARALIKQPTVLILDEATSALDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAH 660
Query: 502 RIICMDQGTIIEQGTHVELMKAKGFYHKLV 531
I+ M G + E GTH EL+K G Y +L+
Sbjct: 661 CIVVMADGRVWEAGTHEELLKKGGLYAELI 690
Score = 231 bits (565), Expect = 1e-59
Identities = 161/488 (32%), Positives = 239/488 (48%), Gaps = 9/488 (1%)
Query: 661 ALLLGYTSGEIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMA 720
AL +I +FD +N G + +RL+ D E + + L I L+ + V +
Sbjct: 213 ALFSSLLRQDITFFD--ANKTGQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSL 270
Query: 721 MSYNWKLTLVSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSL 780
+ +LTL+ P ++G L G +K + +E + A +A EA+ +++TV++
Sbjct: 271 SMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAF 330
Query: 781 GIESLFITRFQDALIDACAAVVKK-SRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXX 839
+E R+ A ++AC ++ R L GL + G LVA
Sbjct: 331 AMEQREEERY-GAELEACRCRAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQL 389
Query: 840 XXXXXXXXXXXXMYGAYMLGQSLVYAPSFNSAKTCGARILSIINREPRIRTVDGLNDKQD 899
+ V + GAR+ + P I G ++
Sbjct: 390 TGGDLMSFLVASQTVQRSMANLSVLFGQVVRGLSAGARVFEYMALNPCIPLSGGCCVPKE 449
Query: 900 WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYD 959
G+ + +V FSYP R +LK L + GK VALVG SG GK+TV L++RFYD
Sbjct: 450 -QLRGSVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYD 508
Query: 960 PTTGNIELDGVDITKSLTLNRLRKQL-GVVQQEPILFDRTLAENIAYGDNSRKPTMDEXX 1018
PT G + LDG D+ ++L + LR Q+ G + QEP+LF T+ ENI +G + + +E
Sbjct: 509 PTAGVVMLDGRDL-RTLDPSWLRGQVVGFISQEPVLFGTTIMENIRFG--KLEASDEEVY 565
Query: 1019 XXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSAL 1078
H FI S P+GY T KQR+ IARALI+ P +L+LDEATSAL
Sbjct: 566 TAAREANAHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSAL 625
Query: 1079 DANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGH 1138
DA SER V EALD A+ GRT + IAHRL+T++ A I V+ G++ E G H EL+ G
Sbjct: 626 DAESERVVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGL 685
Query: 1139 YWQLSKQQ 1146
Y +L ++Q
Sbjct: 686 YAELIRRQ 693
>AK002018-1|BAA92038.1| 735|Homo sapiens protein ( Homo sapiens
cDNA FLJ11156 fis, clone PLACE1006956, weakly similar to
ATP-DEPENDENT PERMEASE MDL1. ).
Length = 735
Score = 318 bits (782), Expect = 6e-86
Identities = 194/510 (38%), Positives = 283/510 (55%), Gaps = 23/510 (4%)
Query: 30 VALVSWSALKQITTIRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAV 89
+ L+S + +R+ +++LRQD+T+FD + L S+++ ++ + K KL +
Sbjct: 213 LVLLSHVGERMAVDMRRALFSSLLRQDITFFDANKTGQLVSRLTTDVQEFKSSF--KLVI 270
Query: 90 VSNLVGTSII--CLCTAFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQA 147
L + + CL + L +L L + P + + + K S + E ++A
Sbjct: 271 SQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARA 330
Query: 148 GKQAEEVLKSVKTVVAFGGENIEVQRYKSLLEP----AEISGSRRGLFTGLGNGFNWVLT 203
A+E L +V+TV AF E E +RY + LE AE G LF GL N +
Sbjct: 331 MGVADEALGNVRTVRAFAMEQREEERYGAELEACHCRAEELGRGIALFQGLSN-----IA 385
Query: 204 YSLNTIGFMY-GTRLIIEDANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFAT 262
++ +G ++ G L+ D ++++ S T MA S+
Sbjct: 386 FNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVA---SQTVQRSMANLSVLF-----GQVVR 437
Query: 263 ARGAAASIFSLLDKHPKIDCLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHI 322
A A +F + +P I ++ G ++ ++V FSYP R ++LK F+L +
Sbjct: 438 GLSAGARVFEYMALNPCIPLSGGCCVPKEQLRGSVTFQNVCFSYPCRPGFEVLKDFTLTL 497
Query: 323 KPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSL-GVVGQE 381
PG+ VALVG SG GK+T+ LL+R YDP G V LDGR+L+TL+ WLR + G + QE
Sbjct: 498 PPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQE 557
Query: 382 PVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQK 441
PVLF TI +NI G EA+ E+VY A A AHEFI + P GY TV+GERG +LSGGQK
Sbjct: 558 PVLFGTTIMENIRFGKLEASDEEVYTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQK 617
Query: 442 QRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCH 501
QR+AIAR+L+++P VL+LDEATSALD SE+ VQ ALDRAS GRT L ++HRLST+ H
Sbjct: 618 QRLAIARALIKQPTVLILDEATSALDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAH 677
Query: 502 RIICMDQGTIIEQGTHVELMKAKGFYHKLV 531
I+ M G + E GTH EL+K G Y +L+
Sbjct: 678 CIVVMADGRVWEAGTHEELLKKGGLYAELI 707
Score = 231 bits (564), Expect = 1e-59
Identities = 161/488 (32%), Positives = 239/488 (48%), Gaps = 9/488 (1%)
Query: 661 ALLLGYTSGEIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMA 720
AL +I +FD +N G + +RL+ D E + + L I L+ + V +
Sbjct: 230 ALFSSLLRQDITFFD--ANKTGQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSL 287
Query: 721 MSYNWKLTLVSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSL 780
+ +LTL+ P ++G L G +K + +E + A +A EA+ +++TV++
Sbjct: 288 SMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAF 347
Query: 781 GIESLFITRFQDALIDACAAVVKK-SRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXX 839
+E R+ A ++AC ++ R L GL + G LVA
Sbjct: 348 AMEQREEERY-GAELEACHCRAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQL 406
Query: 840 XXXXXXXXXXXXMYGAYMLGQSLVYAPSFNSAKTCGARILSIINREPRIRTVDGLNDKQD 899
+ V + GAR+ + P I G ++
Sbjct: 407 TGGDLMSFLVASQTVQRSMANLSVLFGQVVRGLSAGARVFEYMALNPCIPLSGGCCVPKE 466
Query: 900 WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYD 959
G+ + +V FSYP R +LK L + GK VALVG SG GK+TV L++RFYD
Sbjct: 467 -QLRGSVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYD 525
Query: 960 PTTGNIELDGVDITKSLTLNRLRKQL-GVVQQEPILFDRTLAENIAYGDNSRKPTMDEXX 1018
PT G + LDG D+ ++L + LR Q+ G + QEP+LF T+ ENI +G + + +E
Sbjct: 526 PTAGVVMLDGRDL-RTLDPSWLRGQVVGFISQEPVLFGTTIMENIRFG--KLEASDEEVY 582
Query: 1019 XXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSAL 1078
H FI S P+GY T KQR+ IARALI+ P +L+LDEATSAL
Sbjct: 583 TAAREANAHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSAL 642
Query: 1079 DANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGH 1138
DA SER V EALD A+ GRT + IAHRL+T++ A I V+ G++ E G H EL+ G
Sbjct: 643 DAESERVVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGL 702
Query: 1139 YWQLSKQQ 1146
Y +L ++Q
Sbjct: 703 YAELIRRQ 710
>X06181-1|CAA29547.1| 431|Homo sapiens P-glycoprotein (431 AA)
protein.
Length = 431
Score = 317 bits (779), Expect = 1e-85
Identities = 176/427 (41%), Positives = 250/427 (58%), Gaps = 9/427 (2%)
Query: 727 LTLVSTTFLPLMVGSIWLE-GIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESL 785
LTL+ +P++ S +E +++ +++D++E +E+A IATEA+ +I+TV SL E
Sbjct: 1 LTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKE-LEAAGKIATEAIENIRTVVSLTQERK 59
Query: 786 FITRFQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXX 845
F + + + L V+K+ G+ + SY +GA L+ +G
Sbjct: 60 FESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVI 119
Query: 846 XXXXXXMYGAYMLGQSLVYAPSFNSAKTCGARILSIINREPRIRTVDGLNDKQDWSASGN 905
++GA LG + +AP + AK A + + R+P I + K D GN
Sbjct: 120 LVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPD-KFEGN 178
Query: 906 FSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNI 965
+ N+V F+YPTRA+ +L+G+ L V+ G+T+ALVGSSGCGKSTV+QL++RFYDP G +
Sbjct: 179 ITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTV 238
Query: 966 ELD-GVDI-----TKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXX 1019
+D G + K L + LR QLG+V QEPILFD ++AENIAYGDNSR + DE
Sbjct: 239 FVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVS 298
Query: 1020 XXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALD 1079
H FI +LP YET KQR+ IARALIR P++LLLDEATSALD
Sbjct: 299 AAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALD 358
Query: 1080 ANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHY 1139
SE+ V EALD A +GRTCI IAHRL+TI++AD+I V G++ E G H +L+ KG Y
Sbjct: 359 TESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIY 418
Query: 1140 WQLSKQQ 1146
+ + Q
Sbjct: 419 FSMVSVQ 425
Score = 295 bits (724), Expect = 6e-79
Identities = 168/432 (38%), Positives = 252/432 (58%), Gaps = 19/432 (4%)
Query: 111 LALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAFGGEN-I 169
L L + V+P ++ + ++ R+ + AGK A E +++++TVV+ E
Sbjct: 1 LTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKF 60
Query: 170 EVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDANKPDDER 229
E + L P S + ++ G+ + Y F +G LI+ + D
Sbjct: 61 ESMYVEKLYGPYRNSVQKAHIY-GITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRD-- 117
Query: 230 TYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKIDCLSEAGSS 289
+I + +I F +A + P +A A+ +AA +F L ++ P ID SE G
Sbjct: 118 --VILVFSAIVFGA-VALGHASSFAPD---YAKAKLSAAHLFMLFERQPLIDSYSEEGLK 171
Query: 290 PRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLY 349
P + G I+ +V F+YP+R+++ +L+G SL +K G+++ALVGSSGCGKST++QLL+R Y
Sbjct: 172 PDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFY 231
Query: 350 DPNQGSV-------KLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPE--A 400
DP G+V LDG+ K LN+ WLR+ LG+V QEP+LF +I +NIA G
Sbjct: 232 DPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVV 291
Query: 401 TSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLD 460
+ +++ A+ A H FI+ LP+ YET +G++G LSGGQKQRIAIAR+L+R+P +LLLD
Sbjct: 292 SQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLD 351
Query: 461 EATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVEL 520
EATSALD SEK VQ ALD+A GRT + ++HRLSTI N I+ G + E GTH +L
Sbjct: 352 EATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQL 411
Query: 521 MKAKGFYHKLVT 532
+ KG Y +V+
Sbjct: 412 LAQKGIYFSMVS 423
>AF047690-1|AAD15748.1| 718|Homo sapiens ATP-binding cassette
protein M-ABC1 protein.
Length = 718
Score = 315 bits (773), Expect = 7e-85
Identities = 193/510 (37%), Positives = 282/510 (55%), Gaps = 23/510 (4%)
Query: 30 VALVSWSALKQITTIRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAV 89
+ L+S + +R+ +++LRQ++T+FD + L S+++ ++ + K KL +
Sbjct: 196 LVLLSHVGERMAVDMRRALFSSLLRQNITFFDANKTGQLVSRLTTDVQEFKSSF--KLVI 253
Query: 90 VSNLVGTSII--CLCTAFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQA 147
L S + CL + L +L L + P + + + K S + E ++A
Sbjct: 254 SQGLRSCSQVAGCLVSLSMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEHIARA 313
Query: 148 GKQAEEVLKSVKTVVAFGGENIEVQRYKSLLEP----AEISGSRRGLFTGLGNGFNWVLT 203
A+E L +V+TV A E E +RY + LE AE G LF GL N +
Sbjct: 314 MGVADEALGNVRTVRALAMEQREEERYGAELEACRCRAEELGRGIALFQGLSN-----IA 368
Query: 204 YSLNTIGFMY-GTRLIIEDANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFAT 262
++ +G ++ G L+ D ++++ S T MA S+
Sbjct: 369 FNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVA---SQTVQRSMANLSVLF-----GQVVR 420
Query: 263 ARGAAASIFSLLDKHPKIDCLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHI 322
A A +F + +P I ++ G ++ ++V FSYP R ++LK F+L +
Sbjct: 421 GLSAGARVFEYMALNPCIPLSGGCCVPKEQLRGSVTFQNVCFSYPCRPGFEVLKDFTLTL 480
Query: 323 KPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSL-GVVGQE 381
PG+ VALVG SG GK+T+ LL+R YDP G V LDGR+L+TL+ WLR + G + QE
Sbjct: 481 PPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQE 540
Query: 382 PVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQK 441
PVLF TI +NI G EA+ E+VY A A AHEFI + P GY TV+GERG +LSGGQK
Sbjct: 541 PVLFGTTIMENIRFGKLEASDEEVYTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQK 600
Query: 442 QRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCH 501
QR+AIAR+L+++P VL+LDEATSALD SE+ VQ ALDRAS GRT L ++HRLST+ H
Sbjct: 601 QRLAIARALIKQPTVLILDEATSALDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAH 660
Query: 502 RIICMDQGTIIEQGTHVELMKAKGFYHKLV 531
I+ M G + E GTH EL+K G Y +L+
Sbjct: 661 CIVVMADGRVWEAGTHEELLKKGGLYAELI 690
Score = 233 bits (569), Expect = 4e-60
Identities = 163/488 (33%), Positives = 239/488 (48%), Gaps = 9/488 (1%)
Query: 661 ALLLGYTSGEIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMA 720
AL I +FD +N G + +RL+ D E + + L I L+ S V +
Sbjct: 213 ALFSSLLRQNITFFD--ANKTGQLVSRLTTDVQEFKSSFKLVISQGLRSCSQVAGCLVSL 270
Query: 721 MSYNWKLTLVSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSL 780
+ +LTL+ P ++G L G +K + +E + A +A EA+ +++TV++L
Sbjct: 271 SMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEHIARAMGVADEALGNVRTVRAL 330
Query: 781 GIESLFITRFQDALIDACAAVVKK-SRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXX 839
+E R+ A ++AC ++ R L GL + G LVA
Sbjct: 331 AMEQREEERY-GAELEACRCRAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQL 389
Query: 840 XXXXXXXXXXXXMYGAYMLGQSLVYAPSFNSAKTCGARILSIINREPRIRTVDGLNDKQD 899
+ V + GAR+ + P I G ++
Sbjct: 390 TGGDLMSFLVASQTVQRSMANLSVLFGQVVRGLSAGARVFEYMALNPCIPLSGGCCVPKE 449
Query: 900 WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYD 959
G+ + +V FSYP R +LK L + GK VALVG SG GK+TV L++RFYD
Sbjct: 450 -QLRGSVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYD 508
Query: 960 PTTGNIELDGVDITKSLTLNRLRKQL-GVVQQEPILFDRTLAENIAYGDNSRKPTMDEXX 1018
PT G + LDG D+ ++L + LR Q+ G + QEP+LF T+ ENI +G + + +E
Sbjct: 509 PTAGVVMLDGRDL-RTLDPSWLRGQVVGFISQEPVLFGTTIMENIRFG--KLEASDEEVY 565
Query: 1019 XXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSAL 1078
H FI S P+GY T KQR+ IARALI+ P +L+LDEATSAL
Sbjct: 566 TAAREANAHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSAL 625
Query: 1079 DANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGH 1138
DA SER V EALD A+ GRT + IAHRL+T++ A I V+ G++ E G H EL+ G
Sbjct: 626 DAESERVVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGL 685
Query: 1139 YWQLSKQQ 1146
Y +L ++Q
Sbjct: 686 YAELIRRQ 693
>BC064930-1|AAH64930.1| 738|Homo sapiens ATP-binding cassette,
sub-family B (MDR/TAP), member 10 protein.
Length = 738
Score = 313 bits (769), Expect = 2e-84
Identities = 188/525 (35%), Positives = 287/525 (54%), Gaps = 12/525 (2%)
Query: 11 VAIGAFVSIIFSILCNVLSVALVSWSALKQITTIRKLFLTAVLRQDMTWFDTDSDFNLAS 70
+ +G + N + V L+ S + + +R +++LRQ++ +FD L +
Sbjct: 214 LCLGLSAVFLCGAAANAIRVYLMQTSGQRIVNRLRTSLFSSILRQEVAFFDKTRTGELIN 273
Query: 71 KMSENLMKLKEGMGEKLAVVSNLVGTSIICLCTAFPLGWKLALACITVMPFSIMASVALT 130
++S + L + E L+ + + + F + LA ++V+P + +V
Sbjct: 274 RLSSDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYG 333
Query: 131 NYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAFGGENIEVQRYKSLLEPAEISGSRRGL 190
Y K + +S +QA + AEE + +V+TV AFG E E+++Y S ++ + +R+
Sbjct: 334 RYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIEKYASKVDHV-MQLARKEA 392
Query: 191 FTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDANKPDDERTYIIGIVLSITFSVYMATQSI 250
F G L+ +L + +Y L++ A+ +G + S + SI
Sbjct: 393 FARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMT-------VGELSSFLMYAFWVGISI 445
Query: 251 TLCVPHMEVFATARGAAASIFSLLDKHPKIDCLSEAGSSPRRVIGEISLEDVHFSYPSRS 310
GA ++ LL++ PK+ + + G + ++VHF+YP+R
Sbjct: 446 GGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEGVILNEKSFQGALEFKNVHFAYPARP 505
Query: 311 DIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGW 370
++ I + FSL I G ALVG SG GKST+L LL RLYDP G++ LDG +++ LN W
Sbjct: 506 EVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVW 565
Query: 371 LRSSLGVVGQEPVLFRGTIYDNIAIGYPE---ATSEDVYRVAEMAYAHEFIKNLPNGYET 427
LRS +G V QEP+LF +I +NIA G + T+E++ RVAE+A A FI+N P G+ T
Sbjct: 566 LRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNT 625
Query: 428 VIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTT 487
V+GE+G LSGGQKQRIAIAR+LL+ P +LLLDEATSALD +E VQ ALDR GRT
Sbjct: 626 VVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTV 685
Query: 488 LTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELM-KAKGFYHKLV 531
L ++HRLSTI N + + +DQG I E G H EL+ K G Y KL+
Sbjct: 686 LVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLM 730
Score = 241 bits (591), Expect = 8e-63
Identities = 160/483 (33%), Positives = 243/483 (50%), Gaps = 12/483 (2%)
Query: 670 EIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKL-T 728
E+ +FD+ G + RLS DTA + + + L+ + +VG M + L T
Sbjct: 259 EVAFFDK--TRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLAT 316
Query: 729 LVSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFIT 788
V + P+ + ++ + G +K + ++++ AT +A E + +++TV++ G E I
Sbjct: 317 FVLSVVPPVSIIAV-IYGRYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIE 375
Query: 789 RFQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXX 848
++ + K++ R G L S + G +L+
Sbjct: 376 KYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFL 435
Query: 849 XXXMYGAYMLGQSLVYAPSFNSAKTCGARILSIINREPRIRTVDG--LNDKQDWSASGNF 906
+ +G + G R+ ++ REP++ +G LN+K S G
Sbjct: 436 MYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEGVILNEK---SFQGAL 492
Query: 907 SINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIE 966
+V F+YP R I + L + +G ALVG SG GKSTVL L+ R YDP +G I
Sbjct: 493 EFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTIS 552
Query: 967 LDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYG-DNSRKPTMDEXXXXXXXXX 1025
LDG DI + L LR ++G V QEPILF ++AENIAYG D+ T +E
Sbjct: 553 LDGHDI-RQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVAN 611
Query: 1026 XHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERA 1085
FI + P+G+ T KQR+ IARAL+++P++LLLDEATSALDA +E
Sbjct: 612 AVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYL 671
Query: 1086 VTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGL-KGHYWQLSK 1144
V EALD GRT + IAHRL+TIK+A+++ VLD+GKI E G H EL+ G Y +L
Sbjct: 672 VQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLMN 731
Query: 1145 QQN 1147
+Q+
Sbjct: 732 KQS 734
>AL121990-4|CAI22012.1| 738|Homo sapiens ATP-binding cassette,
sub-family B (MDR/TAP), member 10 protein.
Length = 738
Score = 313 bits (769), Expect = 2e-84
Identities = 188/525 (35%), Positives = 287/525 (54%), Gaps = 12/525 (2%)
Query: 11 VAIGAFVSIIFSILCNVLSVALVSWSALKQITTIRKLFLTAVLRQDMTWFDTDSDFNLAS 70
+ +G + N + V L+ S + + +R +++LRQ++ +FD L +
Sbjct: 214 LCLGLSAVFLCGAAANAIRVYLMQTSGQRIVNRLRTSLFSSILRQEVAFFDKTRTGELIN 273
Query: 71 KMSENLMKLKEGMGEKLAVVSNLVGTSIICLCTAFPLGWKLALACITVMPFSIMASVALT 130
++S + L + E L+ + + + F + LA ++V+P + +V
Sbjct: 274 RLSSDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYG 333
Query: 131 NYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAFGGENIEVQRYKSLLEPAEISGSRRGL 190
Y K + +S +QA + AEE + +V+TV AFG E E+++Y S ++ + +R+
Sbjct: 334 RYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIEKYASKVDHV-MQLARKEA 392
Query: 191 FTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDANKPDDERTYIIGIVLSITFSVYMATQSI 250
F G L+ +L + +Y L++ A+ +G + S + SI
Sbjct: 393 FARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMT-------VGELSSFLMYAFWVGISI 445
Query: 251 TLCVPHMEVFATARGAAASIFSLLDKHPKIDCLSEAGSSPRRVIGEISLEDVHFSYPSRS 310
GA ++ LL++ PK+ + + G + ++VHF+YP+R
Sbjct: 446 GGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEGVILNEKSFQGALEFKNVHFAYPARP 505
Query: 311 DIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGW 370
++ I + FSL I G ALVG SG GKST+L LL RLYDP G++ LDG +++ LN W
Sbjct: 506 EVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVW 565
Query: 371 LRSSLGVVGQEPVLFRGTIYDNIAIGYPE---ATSEDVYRVAEMAYAHEFIKNLPNGYET 427
LRS +G V QEP+LF +I +NIA G + T+E++ RVAE+A A FI+N P G+ T
Sbjct: 566 LRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNT 625
Query: 428 VIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTT 487
V+GE+G LSGGQKQRIAIAR+LL+ P +LLLDEATSALD +E VQ ALDR GRT
Sbjct: 626 VVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTV 685
Query: 488 LTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELM-KAKGFYHKLV 531
L ++HRLSTI N + + +DQG I E G H EL+ K G Y KL+
Sbjct: 686 LVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLM 730
Score = 241 bits (591), Expect = 8e-63
Identities = 160/483 (33%), Positives = 243/483 (50%), Gaps = 12/483 (2%)
Query: 670 EIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKL-T 728
E+ +FD+ G + RLS DTA + + + L+ + +VG M + L T
Sbjct: 259 EVAFFDK--TRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLAT 316
Query: 729 LVSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFIT 788
V + P+ + ++ + G +K + ++++ AT +A E + +++TV++ G E I
Sbjct: 317 FVLSVVPPVSIIAV-IYGRYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIE 375
Query: 789 RFQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXX 848
++ + K++ R G L S + G +L+
Sbjct: 376 KYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFL 435
Query: 849 XXXMYGAYMLGQSLVYAPSFNSAKTCGARILSIINREPRIRTVDG--LNDKQDWSASGNF 906
+ +G + G R+ ++ REP++ +G LN+K S G
Sbjct: 436 MYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEGVILNEK---SFQGAL 492
Query: 907 SINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIE 966
+V F+YP R I + L + +G ALVG SG GKSTVL L+ R YDP +G I
Sbjct: 493 EFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTIS 552
Query: 967 LDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYG-DNSRKPTMDEXXXXXXXXX 1025
LDG DI + L LR ++G V QEPILF ++AENIAYG D+ T +E
Sbjct: 553 LDGHDI-RQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVAN 611
Query: 1026 XHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERA 1085
FI + P+G+ T KQR+ IARAL+++P++LLLDEATSALDA +E
Sbjct: 612 AVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYL 671
Query: 1086 VTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGL-KGHYWQLSK 1144
V EALD GRT + IAHRL+TIK+A+++ VLD+GKI E G H EL+ G Y +L
Sbjct: 672 VQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLMN 731
Query: 1145 QQN 1147
+Q+
Sbjct: 732 KQS 734
>AF216833-1|AAF78198.1| 738|Homo sapiens M-ABC2 protein protein.
Length = 738
Score = 308 bits (757), Expect = 6e-83
Identities = 186/525 (35%), Positives = 286/525 (54%), Gaps = 12/525 (2%)
Query: 11 VAIGAFVSIIFSILCNVLSVALVSWSALKQITTIRKLFLTAVLRQDMTWFDTDSDFNLAS 70
+ +G + N + V L+ S + + +R +++LRQ++ +FD L +
Sbjct: 214 LCLGLSAVFLCGAAANAIRVYLMQTSGQRIVNRLRTSLFSSILRQEVAFFDKTRTGELIN 273
Query: 71 KMSENLMKLKEGMGEKLAVVSNLVGTSIICLCTAFPLGWKLALACITVMPFSIMASVALT 130
++S + L + E L+ + + + F + LA ++V+P + +V
Sbjct: 274 RLSSDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYG 333
Query: 131 NYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAFGGENIEVQRYKSLLEPAEISGSRRGL 190
Y K + +S +QA + AEE + +V+TV AFG E E+++Y S ++ + +R+
Sbjct: 334 RYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIEKYASKVDHV-MQLARKEA 392
Query: 191 FTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDANKPDDERTYIIGIVLSITFSVYMATQSI 250
G L+ +L + +Y L++ A+ +G + S + SI
Sbjct: 393 VARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMT-------VGELSSFLMYAFWVGISI 445
Query: 251 TLCVPHMEVFATARGAAASIFSLLDKHPKIDCLSEAGSSPRRVIGEISLEDVHFSYPSRS 310
GA ++ LL++ PK+ + + G + ++VHF+YP+R
Sbjct: 446 GGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEGVILNEKSFQGALEFKNVHFAYPARP 505
Query: 311 DIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGW 370
++ I + FSL I G ALVG SG GKST+L LL RLY+P G++ LDG +++ LN W
Sbjct: 506 EVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYNPASGTISLDGHDIRQLNPVW 565
Query: 371 LRSSLGVVGQEPVLFRGTIYDNIAIGYPE---ATSEDVYRVAEMAYAHEFIKNLPNGYET 427
LRS +G V QEP+LF +I +NIA G + T+E++ RVAE+A A FI+N P G+ T
Sbjct: 566 LRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNT 625
Query: 428 VIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTT 487
V+GE+G LSGGQKQRIAIAR+LL+ P +LLLDEATSALD +E VQ ALDR GRT
Sbjct: 626 VVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTV 685
Query: 488 LTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELM-KAKGFYHKLV 531
L ++HRLSTI N + + +DQG I E G H EL+ K G Y KL+
Sbjct: 686 LVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLM 730
Score = 239 bits (586), Expect = 3e-62
Identities = 159/483 (32%), Positives = 243/483 (50%), Gaps = 12/483 (2%)
Query: 670 EIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKL-T 728
E+ +FD+ G + RLS DTA + + + L+ + +VG M + L T
Sbjct: 259 EVAFFDK--TRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLAT 316
Query: 729 LVSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFIT 788
V + P+ + ++ + G +K + ++++ AT +A E + +++TV++ G E I
Sbjct: 317 FVLSVVPPVSIIAV-IYGRYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIE 375
Query: 789 RFQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXX 848
++ + K++ R G L S + G +L+
Sbjct: 376 KYASKVDHVMQLARKEAVARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFL 435
Query: 849 XXXMYGAYMLGQSLVYAPSFNSAKTCGARILSIINREPRIRTVDG--LNDKQDWSASGNF 906
+ +G + G R+ ++ REP++ +G LN+K S G
Sbjct: 436 MYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEGVILNEK---SFQGAL 492
Query: 907 SINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIE 966
+V F+YP R I + L + +G ALVG SG GKSTVL L+ R Y+P +G I
Sbjct: 493 EFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYNPASGTIS 552
Query: 967 LDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYG-DNSRKPTMDEXXXXXXXXX 1025
LDG DI + L LR ++G V QEPILF ++AENIAYG D+ T +E
Sbjct: 553 LDGHDI-RQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVAN 611
Query: 1026 XHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERA 1085
FI + P+G+ T KQR+ IARAL+++P++LLLDEATSALDA +E
Sbjct: 612 AVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYL 671
Query: 1086 VTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGL-KGHYWQLSK 1144
V EALD GRT + IAHRL+TIK+A+++ VLD+GKI E G H EL+ G Y +L
Sbjct: 672 VQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLMN 731
Query: 1145 QQN 1147
+Q+
Sbjct: 732 KQS 734
>AB013380-1|BAB20265.1| 737|Homo sapiens mono ATP-binding cassette
protein protein.
Length = 737
Score = 301 bits (738), Expect = 1e-80
Identities = 184/525 (35%), Positives = 283/525 (53%), Gaps = 13/525 (2%)
Query: 11 VAIGAFVSIIFSILCNVLSVALVSWSALKQITTIRKLFLTAVLRQDMTWFDTDSDFNLAS 70
+ +G + N + V L+ S + + +R +++LRQ++ +FD L +
Sbjct: 214 LCLGLSAVFLCGAAANAIRVYLMQTSGQRIVNRLRTSLFSSILRQEVAFFDKTRTGELIN 273
Query: 71 KMSENLMKLKEGMGEKLAVVSNLVGTSIICLCTAFPLGWKLALACITVMPFSIMASVALT 130
++S + L + E L+ + + + F + LA ++V+P + +V
Sbjct: 274 RLSSDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYG 333
Query: 131 NYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAFGGENIEVQRYKSLLEPAEISGSRRGL 190
Y K + +S +QA + AEE + +V+TV AFG E E+++Y S ++ + +R+
Sbjct: 334 RYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIEKYASKVDHV-MQLARKEA 392
Query: 191 FTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDANKPDDERTYIIGIVLSITFSVYMATQSI 250
F G L+ +L + +Y L++ A+ +G + S + SI
Sbjct: 393 FARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMT-------VGELSSFLMYAFWVGISI 445
Query: 251 TLCVPHMEVFATARGAAASIFSLLDKHPKIDCLSEAGSSPRRVIGEISLEDVHFSYPSRS 310
GA ++ LL++ PK+ + + G + ++VHF+YP+R
Sbjct: 446 GGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEGVILNEKSFQGALEFKNVHFAYPARP 505
Query: 311 DIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGW 370
++ I + FSL I G ALVG SG GKST+L LL RLYDP G++ LDG +++ LN W
Sbjct: 506 EVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVW 565
Query: 371 LRSSLGVVGQEPVLFRGTIYDNIAIGYPE---ATSEDVYRVAEMAYAHEFIKNLPNGYET 427
LRS +G V QEP+LF +I +NIA G + T+E++ R + A FI+N P G+ T
Sbjct: 566 LRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRGLK-GQAVAFIRNFPQGFNT 624
Query: 428 VIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTT 487
V+GE+G LSGGQKQRIAIAR+LL+ P +LLLDEATSALD +E VQ ALDR GRT
Sbjct: 625 VVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTV 684
Query: 488 LTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELM-KAKGFYHKLV 531
L ++HRLSTI N + + +DQG I E G H EL+ K G Y KL+
Sbjct: 685 LVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLM 729
Score = 239 bits (584), Expect = 5e-62
Identities = 158/482 (32%), Positives = 240/482 (49%), Gaps = 11/482 (2%)
Query: 670 EIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKL-T 728
E+ +FD+ G + RLS DTA + + + L+ + +VG M + L T
Sbjct: 259 EVAFFDK--TRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLAT 316
Query: 729 LVSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFIT 788
V + P+ + ++ + G +K + ++++ AT +A E + +++TV++ G E I
Sbjct: 317 FVLSVVPPVSIIAV-IYGRYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIE 375
Query: 789 RFQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXX 848
++ + K++ R G L S + G +L+
Sbjct: 376 KYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFL 435
Query: 849 XXXMYGAYMLGQSLVYAPSFNSAKTCGARILSIINREPRIRTVDG--LNDKQDWSASGNF 906
+ +G + G R+ ++ REP++ +G LN+K S G
Sbjct: 436 MYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEGVILNEK---SFQGAL 492
Query: 907 SINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIE 966
+V F+YP R I + L + +G ALVG SG GKSTVL L+ R YDP +G I
Sbjct: 493 EFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTIS 552
Query: 967 LDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXX 1026
LDG DI + L LR ++G V QEPILF ++AENIAYG + E
Sbjct: 553 LDGHDI-RQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRGLKGQA 611
Query: 1027 HNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAV 1086
FI + P+G+ T KQR+ IARAL+++P++LLLDEATSALDA +E V
Sbjct: 612 VAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLV 671
Query: 1087 TEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGL-KGHYWQLSKQ 1145
EALD GRT + IAHRL+TIK+A+++ VLD+GKI E G H EL+ G Y +L +
Sbjct: 672 QEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLMNK 731
Query: 1146 QN 1147
Q+
Sbjct: 732 QS 733
>AK172794-1|BAD18770.1| 433|Homo sapiens protein ( Homo sapiens
cDNA FLJ23955 fis, clone HEP11276, highly similar to
Homo sapiens ATP-binding cassette, sub-family B
(MDR/TAP), member ).
Length = 433
Score = 292 bits (716), Expect = 5e-78
Identities = 171/425 (40%), Positives = 246/425 (57%), Gaps = 12/425 (2%)
Query: 111 LALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAFGGENIE 170
LA ++V+P + +V Y K + +S +QA + AEE + +V+TV AFG E E
Sbjct: 9 LATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTE 68
Query: 171 VQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDANKPDDERT 230
+++Y S ++ + +R+ F G L+ +L + +Y L++ A+
Sbjct: 69 IEKYASKVDHV-MQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMT----- 122
Query: 231 YIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKIDCLSEAGSSP 290
+G + S + SI GA ++ LL++ PK+ +
Sbjct: 123 --VGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEGVILNE 180
Query: 291 RRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYD 350
+ G + ++VHF+YP+R ++ I + FSL I G ALVG SG GKST+L LL RLYD
Sbjct: 181 KSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYD 240
Query: 351 PNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPE---ATSEDVYR 407
P G++ LDG +++ LN WLRS +G V QEP+LF +I +NIA G + T+E++ R
Sbjct: 241 PASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQR 300
Query: 408 VAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALD 467
VAE+A A FI+N P G+ TV+GE+G LSGGQKQRIAIAR+LL+ P +LLLDEATSALD
Sbjct: 301 VAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALD 360
Query: 468 PHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELM-KAKGF 526
+E VQ ALDR GRT L ++HRLSTI N + + +DQG I E G H EL+ K G
Sbjct: 361 AENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGI 420
Query: 527 YHKLV 531
Y KL+
Sbjct: 421 YRKLM 425
Score = 230 bits (562), Expect = 2e-59
Identities = 145/424 (34%), Positives = 217/424 (51%), Gaps = 9/424 (2%)
Query: 728 TLVSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFI 787
T V + P+ + ++ + G +K + ++++ AT +A E + +++TV++ G E I
Sbjct: 11 TFVLSVVPPVSIIAV-IYGRYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEI 69
Query: 788 TRFQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXX 847
++ + K++ R G L S + G +L+
Sbjct: 70 EKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSF 129
Query: 848 XXXXMYGAYMLGQSLVYAPSFNSAKTCGARILSIINREPRIRTVDG--LNDKQDWSASGN 905
+ +G + G R+ ++ REP++ +G LN+K S G
Sbjct: 130 LMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEGVILNEK---SFQGA 186
Query: 906 FSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNI 965
+V F+YP R I + L + +G ALVG SG GKSTVL L+ R YDP +G I
Sbjct: 187 LEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTI 246
Query: 966 ELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYG-DNSRKPTMDEXXXXXXXX 1024
LDG DI + L LR ++G V QEPILF ++AENIAYG D+ T +E
Sbjct: 247 SLDGHDI-RQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVA 305
Query: 1025 XXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSER 1084
FI + P+G+ T KQR+ IARAL+++P++LLLDEATSALDA +E
Sbjct: 306 NAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEY 365
Query: 1085 AVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGL-KGHYWQLS 1143
V EALD GRT + IAHRL+TIK+A+++ VLD+GKI E G H EL+ G Y +L
Sbjct: 366 LVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLM 425
Query: 1144 KQQN 1147
+Q+
Sbjct: 426 NKQS 429
>BC141836-1|AAI41837.1| 693|Homo sapiens Unknown (protein for
MGC:165100) protein.
Length = 693
Score = 280 bits (686), Expect = 2e-74
Identities = 176/471 (37%), Positives = 258/471 (54%), Gaps = 23/471 (4%)
Query: 30 VALVSWSALKQITTIRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAV 89
+ L+S + +R+ +++LRQD+T+FD + L S+++ ++ + K KL +
Sbjct: 196 LVLLSHVGERMAVDMRRALFSSLLRQDITFFDANKTGQLVSRLTTDVQEFKSSF--KLVI 253
Query: 90 VSNLVGTSII--CLCTAFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQA 147
L + + CL + L +L L + P + + + K S + E ++A
Sbjct: 254 SQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARA 313
Query: 148 GKQAEEVLKSVKTVVAFGGENIEVQRYKSLLEP----AEISGSRRGLFTGLGNGFNWVLT 203
A+E L +V+TV AF E E +RY + LE AE G LF GL N +
Sbjct: 314 MGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIALFQGLSN-----IA 368
Query: 204 YSLNTIGFMY-GTRLIIEDANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFAT 262
++ +G ++ G L+ D ++++ S T MA S+
Sbjct: 369 FNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVA---SQTVQRSMANLSVLF-----GQVVR 420
Query: 263 ARGAAASIFSLLDKHPKIDCLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHI 322
A A +F + +P I ++ G ++ ++V FSYP R ++LK F+L +
Sbjct: 421 GLSAGARVFEYMALNPCIPLSGGCCVPKEQLRGSVTFQNVCFSYPCRPGFEVLKDFTLTL 480
Query: 323 KPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSL-GVVGQE 381
PG+ VALVG SG GK+T+ LL+R YDP G V LDGR+L+TL+ WLR + G + QE
Sbjct: 481 PPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQE 540
Query: 382 PVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQK 441
PVLF TI +NI G EA+ E+VY A A AHEFI + P GY TV+GERG +LSGGQK
Sbjct: 541 PVLFGTTIMENIRFGKLEASDEEVYTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQK 600
Query: 442 QRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVSH 492
QR+AIAR+L+++P VL+LDEATSALD SE+ VQ ALDRAS GRT L +H
Sbjct: 601 QRLAIARALIKQPTVLILDEATSALDAESERVVQEALDRASAGRTVLAGTH 651
Score = 196 bits (477), Expect = 5e-49
Identities = 143/446 (32%), Positives = 211/446 (47%), Gaps = 9/446 (2%)
Query: 661 ALLLGYTSGEIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMA 720
AL +I +FD +N G + +RL+ D E + + L I L+ + V +
Sbjct: 213 ALFSSLLRQDITFFD--ANKTGQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSL 270
Query: 721 MSYNWKLTLVSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSL 780
+ +LTL+ P ++G L G +K + +E + A +A EA+ +++TV++
Sbjct: 271 SMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAF 330
Query: 781 GIESLFITRFQDALIDACAAVVKK-SRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXX 839
+E R+ A ++AC ++ R L GL + G LVA
Sbjct: 331 AMEQREEERY-GAELEACRCRAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQL 389
Query: 840 XXXXXXXXXXXXMYGAYMLGQSLVYAPSFNSAKTCGARILSIINREPRIRTVDGLNDKQD 899
+ V + GAR+ + P I G ++
Sbjct: 390 TGGDLMSFLVASQTVQRSMANLSVLFGQVVRGLSAGARVFEYMALNPCIPLSGGCCVPKE 449
Query: 900 WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYD 959
G+ + +V FSYP R +LK L + GK VALVG SG GK+TV L++RFYD
Sbjct: 450 -QLRGSVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYD 508
Query: 960 PTTGNIELDGVDITKSLTLNRLRKQL-GVVQQEPILFDRTLAENIAYGDNSRKPTMDEXX 1018
PT G + LDG D+ ++L + LR Q+ G + QEP+LF T+ ENI +G + + +E
Sbjct: 509 PTAGVVMLDGRDL-RTLDPSWLRGQVVGFISQEPVLFGTTIMENIRFG--KLEASDEEVY 565
Query: 1019 XXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSAL 1078
H FI S P+GY T KQR+ IARALI+ P +L+LDEATSAL
Sbjct: 566 TAAREANAHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSAL 625
Query: 1079 DANSERAVTEALDHAAKGRTCITIAH 1104
DA SER V EALD A+ GRT + H
Sbjct: 626 DAESERVVQEALDRASAGRTVLAGTH 651
>AC006154-1|AAD05023.1| 407|Homo sapiens unknown protein.
Length = 407
Score = 258 bits (631), Expect = 1e-67
Identities = 124/328 (37%), Positives = 203/328 (61%), Gaps = 8/328 (2%)
Query: 28 LSVALVSWSALKQITTIRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKL 87
+ V+ + +A +QI IR+ F A+LRQ++ WFD + L +++++++ K+ EG+G+K+
Sbjct: 88 IQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKV 147
Query: 88 AVVSNLVGTSIICLCTAFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQA 147
+ V T F GWKL L + + P +++ + S +E+ +Y++A
Sbjct: 148 GMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKA 207
Query: 148 GKQAEEVLKSVKTVVAFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLN 207
G AEE L +++TV+AFGG+N E++RY+ LE A+ G ++ + + G ++L Y+
Sbjct: 208 GAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASY 267
Query: 208 TIGFMYGTRLIIEDANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAA 267
+ F YG+ L+I + Y IG +++ FS+ + S+ P ++ FA ARGAA
Sbjct: 268 ALAFWYGSTLVIS--------KEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAA 319
Query: 268 ASIFSLLDKHPKIDCLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGES 327
IF ++D +PKID SE G P + G + DVHFSYPSR+++KILKG +L ++ G++
Sbjct: 320 YVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQT 379
Query: 328 VALVGSSGCGKSTILQLLQRLYDPNQGS 355
VALVGSSGCGKST +QL+QRLYDP++G+
Sbjct: 380 VALVGSSGCGKSTTVQLIQRLYDPDEGT 407
Score = 175 bits (427), Expect = 6e-43
Identities = 106/296 (35%), Positives = 160/296 (54%), Gaps = 7/296 (2%)
Query: 670 EIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTL 729
EIG+FD T + RL+ D +++ G ++G+ Q ++ GFI+ WKLTL
Sbjct: 116 EIGWFDINDTT--ELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTL 173
Query: 730 VSTTFLPLM--VGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFI 787
V P++ ++W + I+S S + E A A A+A EA+ +I+TV + G ++ +
Sbjct: 174 VIMAISPILGLSAAVWAK-ILSAFSDK-ELAAYAKAGAVAEEALGAIRTVIAFGGQNKEL 231
Query: 788 TRFQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXX 847
R+Q L +A +KK+ + +G+ + SY A YG+ LV
Sbjct: 232 ERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTV 291
Query: 848 XXXXMYGAYMLGQSLVYAPSFNSAKTCGARILSIINREPRIRTVDGLNDKQDWSASGNFS 907
+ GA+ +GQ+ +F +A+ I II+ P+I + K D S GN
Sbjct: 292 FFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPD-SIKGNLE 350
Query: 908 INDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTG 963
NDV FSYP+RA+ ILKG++L V++G+TVALVGSSGCGKST +QLIQR YDP G
Sbjct: 351 FNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEG 406
>AY523970-1|AAS55411.1| 748|Homo sapiens TAP1 protein.
Length = 748
Score = 253 bits (620), Expect = 2e-66
Identities = 152/493 (30%), Positives = 262/493 (53%), Gaps = 15/493 (3%)
Query: 51 AVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAVVSNLVGTSIICLCTAFPLGWK 110
AVLRQ+ +F + N+ S+++E+ L + + E L++ + + L
Sbjct: 267 AVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGSVS 326
Query: 111 LALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAFGGENIE 170
L + + +P + + + ++ ES +++ + A EVL ++ TV +F E E
Sbjct: 327 LTMVTLVTLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEVLSAMPTVRSFANEEGE 386
Query: 171 VQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMY-GTRLIIEDANKPDDER 229
Q+++ L+ + + + + N + ++ L +G +Y G +L+ A +
Sbjct: 387 AQKFREKLQEIKTLNQKEAVAYAV-NSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLV 445
Query: 230 TYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKIDCLSEAGSS 289
T+++ + F+ A + + P ++ A G++ IF LD+ P+ C +
Sbjct: 446 TFVL---YQMQFT--QAVEVLLSIYPRVQ---KAVGSSEKIFEYLDRTPR--CPPSGLLT 495
Query: 290 PRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLY 349
P + G + +DV F+YP+R DI +L+G + ++PGE ALVG +G GKST+ LLQ LY
Sbjct: 496 PLHLEGLVQFQDVSFAYPNRPDILVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLY 555
Query: 350 DPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPE-ATSEDVYRV 408
P G + LDG+ L +L + VGQEP +F ++ +NIA G + T E++
Sbjct: 556 QPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAA 615
Query: 409 AEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDP 468
A + AH FI LP GY+T +GE G+ LSGGQ+Q +A+AR+L+R+P VL+LD+ATSALD
Sbjct: 616 AVKSGAHSFISGLPQGYDTEVGEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDA 675
Query: 469 HSEKQVQAALDRA--SVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGF 526
+S+ QV+ L + R+ L ++ LS + I+ ++ G I E GTH +LM+ KG
Sbjct: 676 NSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGC 735
Query: 527 YHKLVTSGKETKE 539
Y +V + + E
Sbjct: 736 YWAMVQAPADAPE 748
Score = 196 bits (479), Expect = 3e-49
Identities = 149/507 (29%), Positives = 234/507 (46%), Gaps = 27/507 (5%)
Query: 644 TVGSIAAFIQGACFPVFALLLGYTSGEIGYFDRESNTVGAVCARLSGDTAEVQGATGLRI 703
T+G + + +QG VF +L E +F + N G + +R++ DT+ + + +
Sbjct: 252 TMGHVHSHLQGE---VFGAVLRQ---ETEFF--QQNQTGNIMSRVTEDTSTLSDSLSENL 303
Query: 704 GLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESA 763
L L + + + LT+V+ LPL+ G Q + RE++ +
Sbjct: 304 SLFLWYLVRGLCLLGIMLWGSVSLTMVTLVTLPLLFLLPKKVGKWYQLLEVQVRESLAKS 363
Query: 764 TAIATEAVVSIKTVQSLGIESLFITRFQDALIDACAAVVKKS------RWRGLVLGLCIY 817
+ +A E + ++ TV+S E +F++ L + K++ W + G+ +
Sbjct: 364 SQVAIEVLSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLK 423
Query: 818 VPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXXXXMYGAYMLGQSLVYAPSFNSAKTCGAR 877
V +L G LV G M + L P A +
Sbjct: 424 VGIL------YIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEK 477
Query: 878 ILSIINREPRIRTVDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTV 937
I ++R PR L G DV F+YP R ++L+G+ + G+
Sbjct: 478 IFEYLDRTPRCPPSGLLTPLH---LEGLVQFQDVSFAYPNRPDILVLQGLTFTLRPGEVT 534
Query: 938 ALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDR 997
ALVG +G GKSTV L+Q Y PT G + LDG + + L +Q+ V QEP +F R
Sbjct: 535 ALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQ-YEHRYLHRQVAAVGQEPQVFGR 593
Query: 998 TLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVC 1057
+L ENIAYG ++KPTM+E H+FI LP+GY+T +Q V
Sbjct: 594 SLQENIAYG-LTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVGEAGSQLSGGQRQAVA 652
Query: 1058 IARALIRSPRLLLLDEATSALDANSERAVTEALDHAAK--GRTCITIAHRLTTIKDADII 1115
+ARALIR P +L+LD+ATSALDANS+ V + L + + R+ + I L+ ++ AD I
Sbjct: 653 LARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHI 712
Query: 1116 CVLDKGKIVEKGNHAELIGLKGHYWQL 1142
L+ G I E G H +L+ KG YW +
Sbjct: 713 LFLEGGAIREGGTHQQLMEKKGCYWAM 739
>AF216494-1|AAF89993.1| 766|Homo sapiens ATP-binding cassette
protein ABCB9 protein.
Length = 766
Score = 252 bits (616), Expect = 7e-66
Identities = 155/492 (31%), Positives = 256/492 (52%), Gaps = 18/492 (3%)
Query: 44 IRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAV-VSNLVGTSIICLC 102
+R +++ Q+ ++FD + +L S+++ + + + + + + V + N V + + +
Sbjct: 261 LRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVF 320
Query: 103 TAFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTVV 162
F L W+L+L P +M S Y + S + ++A AEE + ++KTV
Sbjct: 321 M-FSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVR 379
Query: 163 AFGGENIEVQRYKSLLEPAEISGSRRG---LFTGLGNGFNWVLTYSLNTIGFMYGTRLII 219
+F E E + Y L+ + ++ G+G +L ++ + YG L+I
Sbjct: 380 SFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLT-LLVVQVSIL--YYGGHLVI 436
Query: 220 EDANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPK 279
+ +II F + +S+ + GAA +F +D+ P
Sbjct: 437 SGQMTSGNLIAFII-----YEFVLGDCMESVGSVYSGL---MQGVGAAEKVFEFIDRQPT 488
Query: 280 IDCLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKS 339
+ + + +P + G + E+V F+Y +R ++L+ S + PG+ ALVG SG GKS
Sbjct: 489 M--VHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKS 546
Query: 340 TILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPE 399
+ + +L+ Y G V LDG+ + + +L + +V QEPVLF +I DNI+ G P
Sbjct: 547 SCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPT 606
Query: 400 ATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLL 459
E V A+ A AH FI L +GY T GE+GA LSGGQKQR+A+AR+L+R P VL+L
Sbjct: 607 VPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLIL 666
Query: 460 DEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVE 519
DEATSALD SE +Q A+ T L ++HRLST+ + H I+ +D+G +++QGTH +
Sbjct: 667 DEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQ 726
Query: 520 LMKAKGFYHKLV 531
L+ G Y KLV
Sbjct: 727 LLAQGGLYAKLV 738
Score = 206 bits (504), Expect = 3e-52
Identities = 157/524 (29%), Positives = 248/524 (47%), Gaps = 37/524 (7%)
Query: 643 LTVGS-IAAFIQGACFP-VFA---------LLLGYTSGEIGYFDRESNTVGAVCARLSGD 691
L +GS AA I+G F +FA L S E +FD N G + +RL+ D
Sbjct: 235 LAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDE--NRTGDLISRLTSD 292
Query: 692 TAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGSIWLEGIMSQK 751
T V I + L+ VT + S +W+L+LV+ P+++ + G ++
Sbjct: 293 TTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKR 352
Query: 752 SQQDEREAMESATAIATEAVVSIKTVQSLGIES----LFITRFQDA--LIDACAAVVKKS 805
++ + A+ A+ A E + ++KTV+S E +++ + Q L AA
Sbjct: 353 LSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYY 412
Query: 806 RWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXXXX-MYGAYMLGQSLVY 864
W GL + L+ S + YG LV G + G M VY
Sbjct: 413 VWGS---GLTL---LVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVY 466
Query: 865 APSFNSAKTCGARILSIINREPRIRTVDGLNDKQDWSASGNFSINDVEFSYPTRAHQMIL 924
+ ++ I+R+P + L G +V F+Y TR H +L
Sbjct: 467 SGLMQGVGAA-EKVFEFIDRQPTMVHDGSLAPDH---LEGRVDFENVTFTYRTRPHTQVL 522
Query: 925 KGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQ 984
+ + + GK ALVG SG GKS+ + +++ FY G + LDG I+ + L +
Sbjct: 523 QNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPIS-AYDHKYLHRV 581
Query: 985 LGVVQQEPILFDRTLAENIAYGDNSRKPTM--DEXXXXXXXXXXHNFIVSLPKGYETNXX 1042
+ +V QEP+LF R++ +NI+YG PT+ + H FI+ L GY T
Sbjct: 582 ISLVSQEPVLFARSITDNISYG----LPTVPFEMVVEAAQKANAHGFIMELQDGYSTETG 637
Query: 1043 XXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITI 1102
KQRV +ARAL+R+P +L+LDEATSALDA SE + +A+ + T + I
Sbjct: 638 EKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLII 697
Query: 1103 AHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSKQQ 1146
AHRL+T++ A +I VLDKG++V++G H +L+ G Y +L ++Q
Sbjct: 698 AHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQ 741
>AB177852-1|BAD66830.1| 796|Homo sapiens KIAA1520 splice variant 1
protein.
Length = 796
Score = 252 bits (616), Expect = 7e-66
Identities = 155/492 (31%), Positives = 256/492 (52%), Gaps = 18/492 (3%)
Query: 44 IRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAV-VSNLVGTSIICLC 102
+R +++ Q+ ++FD + +L S+++ + + + + + + V + N V + + +
Sbjct: 291 LRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVF 350
Query: 103 TAFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTVV 162
F L W+L+L P +M S Y + S + ++A AEE + ++KTV
Sbjct: 351 M-FSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVR 409
Query: 163 AFGGENIEVQRYKSLLEPAEISGSRRG---LFTGLGNGFNWVLTYSLNTIGFMYGTRLII 219
+F E E + Y L+ + ++ G+G +L ++ + YG L+I
Sbjct: 410 SFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLT-LLVVQVSIL--YYGGHLVI 466
Query: 220 EDANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPK 279
+ +II F + +S+ + GAA +F +D+ P
Sbjct: 467 SGQMTSGNLIAFII-----YEFVLGDCMESVGSVYSGL---MQGVGAAEKVFEFIDRQPT 518
Query: 280 IDCLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKS 339
+ + + +P + G + E+V F+Y +R ++L+ S + PG+ ALVG SG GKS
Sbjct: 519 M--VHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKS 576
Query: 340 TILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPE 399
+ + +L+ Y G V LDG+ + + +L + +V QEPVLF +I DNI+ G P
Sbjct: 577 SCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPT 636
Query: 400 ATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLL 459
E V A+ A AH FI L +GY T GE+GA LSGGQKQR+A+AR+L+R P VL+L
Sbjct: 637 VPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLIL 696
Query: 460 DEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVE 519
DEATSALD SE +Q A+ T L ++HRLST+ + H I+ +D+G +++QGTH +
Sbjct: 697 DEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQ 756
Query: 520 LMKAKGFYHKLV 531
L+ G Y KLV
Sbjct: 757 LLAQGGLYAKLV 768
Score = 206 bits (504), Expect = 3e-52
Identities = 157/524 (29%), Positives = 248/524 (47%), Gaps = 37/524 (7%)
Query: 643 LTVGS-IAAFIQGACFP-VFA---------LLLGYTSGEIGYFDRESNTVGAVCARLSGD 691
L +GS AA I+G F +FA L S E +FD N G + +RL+ D
Sbjct: 265 LAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDE--NRTGDLISRLTSD 322
Query: 692 TAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGSIWLEGIMSQK 751
T V I + L+ VT + S +W+L+LV+ P+++ + G ++
Sbjct: 323 TTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKR 382
Query: 752 SQQDEREAMESATAIATEAVVSIKTVQSLGIES----LFITRFQDA--LIDACAAVVKKS 805
++ + A+ A+ A E + ++KTV+S E +++ + Q L AA
Sbjct: 383 LSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYY 442
Query: 806 RWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXXXX-MYGAYMLGQSLVY 864
W GL + L+ S + YG LV G + G M VY
Sbjct: 443 VWGS---GLTL---LVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVY 496
Query: 865 APSFNSAKTCGARILSIINREPRIRTVDGLNDKQDWSASGNFSINDVEFSYPTRAHQMIL 924
+ ++ I+R+P + L G +V F+Y TR H +L
Sbjct: 497 SGLMQGVGAA-EKVFEFIDRQPTMVHDGSLAPDH---LEGRVDFENVTFTYRTRPHTQVL 552
Query: 925 KGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQ 984
+ + + GK ALVG SG GKS+ + +++ FY G + LDG I+ + L +
Sbjct: 553 QNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPIS-AYDHKYLHRV 611
Query: 985 LGVVQQEPILFDRTLAENIAYGDNSRKPTM--DEXXXXXXXXXXHNFIVSLPKGYETNXX 1042
+ +V QEP+LF R++ +NI+YG PT+ + H FI+ L GY T
Sbjct: 612 ISLVSQEPVLFARSITDNISYG----LPTVPFEMVVEAAQKANAHGFIMELQDGYSTETG 667
Query: 1043 XXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITI 1102
KQRV +ARAL+R+P +L+LDEATSALDA SE + +A+ + T + I
Sbjct: 668 EKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLII 727
Query: 1103 AHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSKQQ 1146
AHRL+T++ A +I VLDKG++V++G H +L+ G Y +L ++Q
Sbjct: 728 AHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQ 771
>AB045381-1|BAA97989.2| 766|Homo sapiens TAPL protein.
Length = 766
Score = 252 bits (616), Expect = 7e-66
Identities = 155/492 (31%), Positives = 256/492 (52%), Gaps = 18/492 (3%)
Query: 44 IRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAV-VSNLVGTSIICLC 102
+R +++ Q+ ++FD + +L S+++ + + + + + + V + N V + + +
Sbjct: 261 LRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVF 320
Query: 103 TAFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTVV 162
F L W+L+L P +M S Y + S + ++A AEE + ++KTV
Sbjct: 321 M-FSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVR 379
Query: 163 AFGGENIEVQRYKSLLEPAEISGSRRG---LFTGLGNGFNWVLTYSLNTIGFMYGTRLII 219
+F E E + Y L+ + ++ G+G +L ++ + YG L+I
Sbjct: 380 SFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLT-LLVVQVSIL--YYGGHLVI 436
Query: 220 EDANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPK 279
+ +II F + +S+ + GAA +F +D+ P
Sbjct: 437 SGQMTSGNLIAFII-----YEFVLGDCMESVGSVYSGL---MQGVGAAEKVFEFIDRQPT 488
Query: 280 IDCLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKS 339
+ + + +P + G + E+V F+Y +R ++L+ S + PG+ ALVG SG GKS
Sbjct: 489 M--VHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKS 546
Query: 340 TILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPE 399
+ + +L+ Y G V LDG+ + + +L + +V QEPVLF +I DNI+ G P
Sbjct: 547 SCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPT 606
Query: 400 ATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLL 459
E V A+ A AH FI L +GY T GE+GA LSGGQKQR+A+AR+L+R P VL+L
Sbjct: 607 VPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLIL 666
Query: 460 DEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVE 519
DEATSALD SE +Q A+ T L ++HRLST+ + H I+ +D+G +++QGTH +
Sbjct: 667 DEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQ 726
Query: 520 LMKAKGFYHKLV 531
L+ G Y KLV
Sbjct: 727 LLAQGGLYAKLV 738
Score = 206 bits (504), Expect = 3e-52
Identities = 157/524 (29%), Positives = 248/524 (47%), Gaps = 37/524 (7%)
Query: 643 LTVGS-IAAFIQGACFP-VFA---------LLLGYTSGEIGYFDRESNTVGAVCARLSGD 691
L +GS AA I+G F +FA L S E +FD N G + +RL+ D
Sbjct: 235 LAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDE--NRTGDLISRLTSD 292
Query: 692 TAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGSIWLEGIMSQK 751
T V I + L+ VT + S +W+L+LV+ P+++ + G ++
Sbjct: 293 TTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKR 352
Query: 752 SQQDEREAMESATAIATEAVVSIKTVQSLGIES----LFITRFQDA--LIDACAAVVKKS 805
++ + A+ A+ A E + ++KTV+S E +++ + Q L AA
Sbjct: 353 LSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYY 412
Query: 806 RWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXXXX-MYGAYMLGQSLVY 864
W GL + L+ S + YG LV G + G M VY
Sbjct: 413 VWGS---GLTL---LVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVY 466
Query: 865 APSFNSAKTCGARILSIINREPRIRTVDGLNDKQDWSASGNFSINDVEFSYPTRAHQMIL 924
+ ++ I+R+P + L G +V F+Y TR H +L
Sbjct: 467 SGLMQGVGAA-EKVFEFIDRQPTMVHDGSLAPDH---LEGRVDFENVTFTYRTRPHTQVL 522
Query: 925 KGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQ 984
+ + + GK ALVG SG GKS+ + +++ FY G + LDG I+ + L +
Sbjct: 523 QNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPIS-AYDHKYLHRV 581
Query: 985 LGVVQQEPILFDRTLAENIAYGDNSRKPTM--DEXXXXXXXXXXHNFIVSLPKGYETNXX 1042
+ +V QEP+LF R++ +NI+YG PT+ + H FI+ L GY T
Sbjct: 582 ISLVSQEPVLFARSITDNISYG----LPTVPFEMVVEAAQKANAHGFIMELQDGYSTETG 637
Query: 1043 XXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITI 1102
KQRV +ARAL+R+P +L+LDEATSALDA SE + +A+ + T + I
Sbjct: 638 EKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLII 697
Query: 1103 AHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSKQQ 1146
AHRL+T++ A +I VLDKG++V++G H +L+ G Y +L ++Q
Sbjct: 698 AHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQ 741
>AB040953-1|BAA96044.2| 810|Homo sapiens KIAA1520 protein protein.
Length = 810
Score = 252 bits (616), Expect = 7e-66
Identities = 155/492 (31%), Positives = 256/492 (52%), Gaps = 18/492 (3%)
Query: 44 IRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAV-VSNLVGTSIICLC 102
+R +++ Q+ ++FD + +L S+++ + + + + + + V + N V + + +
Sbjct: 305 LRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVF 364
Query: 103 TAFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTVV 162
F L W+L+L P +M S Y + S + ++A AEE + ++KTV
Sbjct: 365 M-FSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVR 423
Query: 163 AFGGENIEVQRYKSLLEPAEISGSRRG---LFTGLGNGFNWVLTYSLNTIGFMYGTRLII 219
+F E E + Y L+ + ++ G+G +L ++ + YG L+I
Sbjct: 424 SFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLT-LLVVQVSIL--YYGGHLVI 480
Query: 220 EDANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPK 279
+ +II F + +S+ + GAA +F +D+ P
Sbjct: 481 SGQMTSGNLIAFII-----YEFVLGDCMESVGSVYSGL---MQGVGAAEKVFEFIDRQPT 532
Query: 280 IDCLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKS 339
+ + + +P + G + E+V F+Y +R ++L+ S + PG+ ALVG SG GKS
Sbjct: 533 M--VHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKS 590
Query: 340 TILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPE 399
+ + +L+ Y G V LDG+ + + +L + +V QEPVLF +I DNI+ G P
Sbjct: 591 SCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPT 650
Query: 400 ATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLL 459
E V A+ A AH FI L +GY T GE+GA LSGGQKQR+A+AR+L+R P VL+L
Sbjct: 651 VPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLIL 710
Query: 460 DEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVE 519
DEATSALD SE +Q A+ T L ++HRLST+ + H I+ +D+G +++QGTH +
Sbjct: 711 DEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQ 770
Query: 520 LMKAKGFYHKLV 531
L+ G Y KLV
Sbjct: 771 LLAQGGLYAKLV 782
Score = 206 bits (504), Expect = 3e-52
Identities = 157/524 (29%), Positives = 248/524 (47%), Gaps = 37/524 (7%)
Query: 643 LTVGS-IAAFIQGACFP-VFA---------LLLGYTSGEIGYFDRESNTVGAVCARLSGD 691
L +GS AA I+G F +FA L S E +FD N G + +RL+ D
Sbjct: 279 LAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDE--NRTGDLISRLTSD 336
Query: 692 TAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGSIWLEGIMSQK 751
T V I + L+ VT + S +W+L+LV+ P+++ + G ++
Sbjct: 337 TTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKR 396
Query: 752 SQQDEREAMESATAIATEAVVSIKTVQSLGIES----LFITRFQDA--LIDACAAVVKKS 805
++ + A+ A+ A E + ++KTV+S E +++ + Q L AA
Sbjct: 397 LSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYY 456
Query: 806 RWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXXXX-MYGAYMLGQSLVY 864
W GL + L+ S + YG LV G + G M VY
Sbjct: 457 VWGS---GLTL---LVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVY 510
Query: 865 APSFNSAKTCGARILSIINREPRIRTVDGLNDKQDWSASGNFSINDVEFSYPTRAHQMIL 924
+ ++ I+R+P + L G +V F+Y TR H +L
Sbjct: 511 SGLMQGVGAA-EKVFEFIDRQPTMVHDGSLAPDH---LEGRVDFENVTFTYRTRPHTQVL 566
Query: 925 KGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQ 984
+ + + GK ALVG SG GKS+ + +++ FY G + LDG I+ + L +
Sbjct: 567 QNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPIS-AYDHKYLHRV 625
Query: 985 LGVVQQEPILFDRTLAENIAYGDNSRKPTM--DEXXXXXXXXXXHNFIVSLPKGYETNXX 1042
+ +V QEP+LF R++ +NI+YG PT+ + H FI+ L GY T
Sbjct: 626 ISLVSQEPVLFARSITDNISYG----LPTVPFEMVVEAAQKANAHGFIMELQDGYSTETG 681
Query: 1043 XXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITI 1102
KQRV +ARAL+R+P +L+LDEATSALDA SE + +A+ + T + I
Sbjct: 682 EKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLII 741
Query: 1103 AHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSKQQ 1146
AHRL+T++ A +I VLDKG++V++G H +L+ G Y +L ++Q
Sbjct: 742 AHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQ 785
>L21206-1|AAC12904.1| 748|Homo sapiens peptide transporter protein.
Length = 748
Score = 251 bits (615), Expect = 9e-66
Identities = 150/493 (30%), Positives = 261/493 (52%), Gaps = 15/493 (3%)
Query: 51 AVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAVVSNLVGTSIICLCTAFPLGWK 110
AVLRQ+ +F + N+ S+++E+ L + + E L++ + + L
Sbjct: 267 AVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGSVS 326
Query: 111 LALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAFGGENIE 170
L + + +P + + + ++ ES +++ + A E L ++ TV +F E E
Sbjct: 327 LTMVTLVTLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGE 386
Query: 171 VQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMY-GTRLIIEDANKPDDER 229
Q+++ L+ + + + + N + ++ L +G +Y G +L+ A +
Sbjct: 387 AQKFREKLQEIKTLNQKEAVAYAV-NSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLV 445
Query: 230 TYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKIDCLSEAGSS 289
T+++ + F+ A + + P ++ A G++ IF LD+ P+ C +
Sbjct: 446 TFVL---YQMQFT--QAVEVLLSIYPRVQ---KAVGSSEKIFEYLDRTPR--CPPSGLLT 495
Query: 290 PRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLY 349
P + G + +DV F+YP+R D+ +L+G + ++PGE ALVG +G GKST+ LLQ LY
Sbjct: 496 PLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLY 555
Query: 350 DPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPE-ATSEDVYRV 408
P G + LDG+ L +L + VGQEP +F ++ +NIA G + T E++
Sbjct: 556 QPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAA 615
Query: 409 AEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDP 468
A + AH FI LP GY+T +GE G+ LSGGQ+Q +A+AR+L+R+P VL+LD+ATSALD
Sbjct: 616 AVKSGAHSFISGLPQGYDTEVGEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDA 675
Query: 469 HSEKQVQAALDRA--SVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGF 526
+S+ QV+ L + R+ L ++ LS + I+ ++ G I E GTH +LM+ KG
Sbjct: 676 NSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGC 735
Query: 527 YHKLVTSGKETKE 539
Y +V + + E
Sbjct: 736 YWAMVQAPADAPE 748
Score = 198 bits (484), Expect = 7e-50
Identities = 150/507 (29%), Positives = 235/507 (46%), Gaps = 27/507 (5%)
Query: 644 TVGSIAAFIQGACFPVFALLLGYTSGEIGYFDRESNTVGAVCARLSGDTAEVQGATGLRI 703
T+G + + +QG VF +L E +F + N G + +R++ DT+ + + +
Sbjct: 252 TMGHVHSHLQGE---VFGAVLRQ---ETEFF--QQNQTGNIMSRVTEDTSTLSDSLSENL 303
Query: 704 GLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESA 763
L L + + + LT+V+ LPL+ G Q + RE++ +
Sbjct: 304 SLFLWYLVRGLCLLGIMLWGSVSLTMVTLVTLPLLFLLPKKVGKWYQLLEVQVRESLAKS 363
Query: 764 TAIATEAVVSIKTVQSLGIESLFITRFQDALIDACAAVVKKS------RWRGLVLGLCIY 817
+ +A EA+ ++ TV+S E +F++ L + K++ W + G+ +
Sbjct: 364 SQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLK 423
Query: 818 VPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXXXXMYGAYMLGQSLVYAPSFNSAKTCGAR 877
V +L G LV G M + L P A +
Sbjct: 424 VGIL------YIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEK 477
Query: 878 ILSIINREPRIRTVDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTV 937
I ++R PR L G DV F+YP R ++L+G+ + G+
Sbjct: 478 IFEYLDRTPRCPPSGLLTPLH---LEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVT 534
Query: 938 ALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDR 997
ALVG +G GKSTV L+Q Y PT G + LDG + + L +Q+ V QEP +F R
Sbjct: 535 ALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQ-YEHRYLHRQVAAVGQEPQVFGR 593
Query: 998 TLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVC 1057
+L ENIAYG ++KPTM+E H+FI LP+GY+T +Q V
Sbjct: 594 SLQENIAYG-LTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVGEAGSQLSGGQRQAVA 652
Query: 1058 IARALIRSPRLLLLDEATSALDANSERAVTEALDHAAK--GRTCITIAHRLTTIKDADII 1115
+ARALIR P +L+LD+ATSALDANS+ V + L + + R+ + I L+ ++ AD I
Sbjct: 653 LARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHI 712
Query: 1116 CVLDKGKIVEKGNHAELIGLKGHYWQL 1142
L+ G I E G H +L+ KG YW +
Sbjct: 713 LFLEGGAIREGGTHQQLMEKKGCYWAM 739
>L21205-1|AAC12903.1| 748|Homo sapiens peptide transporter protein.
Length = 748
Score = 251 bits (615), Expect = 9e-66
Identities = 150/493 (30%), Positives = 261/493 (52%), Gaps = 15/493 (3%)
Query: 51 AVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAVVSNLVGTSIICLCTAFPLGWK 110
AVLRQ+ +F + N+ S+++E+ L + + E L++ + + L
Sbjct: 267 AVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGSVS 326
Query: 111 LALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAFGGENIE 170
L + + +P + + + ++ ES +++ + A E L ++ TV +F E E
Sbjct: 327 LTMVTLVTLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGE 386
Query: 171 VQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMY-GTRLIIEDANKPDDER 229
Q+++ L+ + + + + N + ++ L +G +Y G +L+ A +
Sbjct: 387 AQKFREKLQEIKTLNQKEAVAYAV-NSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLV 445
Query: 230 TYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKIDCLSEAGSS 289
T+++ + F+ A + + P ++ A G++ IF LD+ P+ C +
Sbjct: 446 TFVL---YQMQFT--QAVEVLLSIYPRVQ---KAVGSSEKIFEYLDRTPR--CPPSGLLT 495
Query: 290 PRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLY 349
P + G + +DV F+YP+R D+ +L+G + ++PGE ALVG +G GKST+ LLQ LY
Sbjct: 496 PLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLY 555
Query: 350 DPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPE-ATSEDVYRV 408
P G + LDG+ L +L + VGQEP +F ++ +NIA G + T E++
Sbjct: 556 QPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAA 615
Query: 409 AEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDP 468
A + AH FI LP GY+T +GE G+ LSGGQ+Q +A+AR+L+R+P VL+LD+ATSALD
Sbjct: 616 AVKSGAHSFISGLPQGYDTEVGEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDA 675
Query: 469 HSEKQVQAALDRA--SVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGF 526
+S+ QV+ L + R+ L ++ LS + I+ ++ G I E GTH +LM+ KG
Sbjct: 676 NSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGC 735
Query: 527 YHKLVTSGKETKE 539
Y +V + + E
Sbjct: 736 YWAMVQAPADAPE 748
Score = 198 bits (484), Expect = 7e-50
Identities = 150/507 (29%), Positives = 235/507 (46%), Gaps = 27/507 (5%)
Query: 644 TVGSIAAFIQGACFPVFALLLGYTSGEIGYFDRESNTVGAVCARLSGDTAEVQGATGLRI 703
T+G + + +QG VF +L E +F + N G + +R++ DT+ + + +
Sbjct: 252 TMGHVHSHLQGE---VFGAVLRQ---ETEFF--QQNQTGNIMSRVTEDTSTLSDSLSENL 303
Query: 704 GLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESA 763
L L + + + LT+V+ LPL+ G Q + RE++ +
Sbjct: 304 SLFLWYLVRGLCLLGIMLWGSVSLTMVTLVTLPLLFLLPKKVGKWYQLLEVQVRESLAKS 363
Query: 764 TAIATEAVVSIKTVQSLGIESLFITRFQDALIDACAAVVKKS------RWRGLVLGLCIY 817
+ +A EA+ ++ TV+S E +F++ L + K++ W + G+ +
Sbjct: 364 SQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLK 423
Query: 818 VPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXXXXMYGAYMLGQSLVYAPSFNSAKTCGAR 877
V +L G LV G M + L P A +
Sbjct: 424 VGIL------YIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEK 477
Query: 878 ILSIINREPRIRTVDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTV 937
I ++R PR L G DV F+YP R ++L+G+ + G+
Sbjct: 478 IFEYLDRTPRCPPSGLLTPLH---LEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVT 534
Query: 938 ALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDR 997
ALVG +G GKSTV L+Q Y PT G + LDG + + L +Q+ V QEP +F R
Sbjct: 535 ALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQ-YEHRYLHRQVAAVGQEPQVFGR 593
Query: 998 TLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVC 1057
+L ENIAYG ++KPTM+E H+FI LP+GY+T +Q V
Sbjct: 594 SLQENIAYG-LTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVGEAGSQLSGGQRQAVA 652
Query: 1058 IARALIRSPRLLLLDEATSALDANSERAVTEALDHAAK--GRTCITIAHRLTTIKDADII 1115
+ARALIR P +L+LD+ATSALDANS+ V + L + + R+ + I L+ ++ AD I
Sbjct: 653 LARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHI 712
Query: 1116 CVLDKGKIVEKGNHAELIGLKGHYWQL 1142
L+ G I E G H +L+ KG YW +
Sbjct: 713 LFLEGGAIREGGTHQQLMEKKGCYWAM 739
>AY523971-1|AAS55412.1| 748|Homo sapiens TAP1 protein.
Length = 748
Score = 251 bits (615), Expect = 9e-66
Identities = 150/493 (30%), Positives = 261/493 (52%), Gaps = 15/493 (3%)
Query: 51 AVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAVVSNLVGTSIICLCTAFPLGWK 110
AVLRQ+ +F + N+ S+++E+ L + + E L++ + + L
Sbjct: 267 AVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGSVS 326
Query: 111 LALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAFGGENIE 170
L + + +P + + + ++ ES +++ + A E L ++ TV +F E E
Sbjct: 327 LTMVTLVTLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGE 386
Query: 171 VQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMY-GTRLIIEDANKPDDER 229
Q+++ L+ + + + + N + ++ L +G +Y G +L+ A +
Sbjct: 387 AQKFREKLQEIKTLNQKEAVAYAV-NSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLV 445
Query: 230 TYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKIDCLSEAGSS 289
T+++ + F+ A + + P ++ A G++ IF LD+ P+ C +
Sbjct: 446 TFVL---YQMQFT--QAVEVLLSIYPRVQ---KAVGSSEKIFEYLDRTPR--CPPSGLLT 495
Query: 290 PRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLY 349
P + G + +DV F+YP+R D+ +L+G + ++PGE ALVG +G GKST+ LLQ LY
Sbjct: 496 PLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLY 555
Query: 350 DPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPE-ATSEDVYRV 408
P G + LDG+ L +L + VGQEP +F ++ +NIA G + T E++
Sbjct: 556 QPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAA 615
Query: 409 AEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDP 468
A + AH FI LP GY+T +GE G+ LSGGQ+Q +A+AR+L+R+P VL+LD+ATSALD
Sbjct: 616 AVKSGAHSFISGLPQGYDTEVGEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDA 675
Query: 469 HSEKQVQAALDRA--SVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGF 526
+S+ QV+ L + R+ L ++ LS + I+ ++ G I E GTH +LM+ KG
Sbjct: 676 NSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGC 735
Query: 527 YHKLVTSGKETKE 539
Y +V + + E
Sbjct: 736 YWAMVQAPADAPE 748
Score = 198 bits (484), Expect = 7e-50
Identities = 150/507 (29%), Positives = 235/507 (46%), Gaps = 27/507 (5%)
Query: 644 TVGSIAAFIQGACFPVFALLLGYTSGEIGYFDRESNTVGAVCARLSGDTAEVQGATGLRI 703
T+G + + +QG VF +L E +F + N G + +R++ DT+ + + +
Sbjct: 252 TMGHVHSHLQGE---VFGAVLRQ---ETEFF--QQNQTGNIMSRVTEDTSTLSDSLSENL 303
Query: 704 GLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESA 763
L L + + + LT+V+ LPL+ G Q + RE++ +
Sbjct: 304 SLFLWYLVRGLCLLGIMLWGSVSLTMVTLVTLPLLFLLPKKVGKWYQLLEVQVRESLAKS 363
Query: 764 TAIATEAVVSIKTVQSLGIESLFITRFQDALIDACAAVVKKS------RWRGLVLGLCIY 817
+ +A EA+ ++ TV+S E +F++ L + K++ W + G+ +
Sbjct: 364 SQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLK 423
Query: 818 VPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXXXXMYGAYMLGQSLVYAPSFNSAKTCGAR 877
V +L G LV G M + L P A +
Sbjct: 424 VGIL------YIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEK 477
Query: 878 ILSIINREPRIRTVDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTV 937
I ++R PR L G DV F+YP R ++L+G+ + G+
Sbjct: 478 IFEYLDRTPRCPPSGLLTPLH---LEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVT 534
Query: 938 ALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDR 997
ALVG +G GKSTV L+Q Y PT G + LDG + + L +Q+ V QEP +F R
Sbjct: 535 ALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQ-YEHRYLHRQVAAVGQEPQVFGR 593
Query: 998 TLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVC 1057
+L ENIAYG ++KPTM+E H+FI LP+GY+T +Q V
Sbjct: 594 SLQENIAYG-LTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVGEAGSQLSGGQRQAVA 652
Query: 1058 IARALIRSPRLLLLDEATSALDANSERAVTEALDHAAK--GRTCITIAHRLTTIKDADII 1115
+ARALIR P +L+LD+ATSALDANS+ V + L + + R+ + I L+ ++ AD I
Sbjct: 653 LARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHI 712
Query: 1116 CVLDKGKIVEKGNHAELIGLKGHYWQL 1142
L+ G I E G H +L+ KG YW +
Sbjct: 713 LFLEGGAIREGGTHQQLMEKKGCYWAM 739
>L21207-1|AAC12905.1| 748|Homo sapiens peptide transporter protein.
Length = 748
Score = 250 bits (613), Expect = 2e-65
Identities = 150/493 (30%), Positives = 261/493 (52%), Gaps = 15/493 (3%)
Query: 51 AVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAVVSNLVGTSIICLCTAFPLGWK 110
AVLRQ+ +F + N+ S+++E+ L + + E L++ + + L
Sbjct: 267 AVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGSVS 326
Query: 111 LALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAFGGENIE 170
L + + +P + + + ++ ES +++ + A E L ++ TV +F E E
Sbjct: 327 LTMVTLVTLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGE 386
Query: 171 VQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMY-GTRLIIEDANKPDDER 229
Q+++ L+ + + + + N + ++ L +G +Y G +L+ A +
Sbjct: 387 AQKFREKLQEIKTLNQKEAVAYAV-NSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLV 445
Query: 230 TYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKIDCLSEAGSS 289
T+++ + F+ A + + P ++ A G++ IF LD+ P+ C +
Sbjct: 446 TFVL---YQMQFT--QALEVLLSIYPRVQ---KAVGSSEKIFEYLDRTPR--CPPSGLLT 495
Query: 290 PRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLY 349
P + G + +DV F+YP+R D+ +L+G + ++PGE ALVG +G GKST+ LLQ LY
Sbjct: 496 PLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLY 555
Query: 350 DPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPE-ATSEDVYRV 408
P G + LDG+ L +L + VGQEP +F ++ +NIA G + T E++
Sbjct: 556 QPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAA 615
Query: 409 AEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDP 468
A + AH FI LP GY+T +GE G+ LSGGQ+Q +A+AR+L+R+P VL+LD+ATSALD
Sbjct: 616 AVKSGAHSFISGLPQGYDTEVGEAGSQLSGGQQQAVALARALIRKPCVLILDDATSALDA 675
Query: 469 HSEKQVQAALDRA--SVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGF 526
+S+ QV+ L + R+ L ++ LS + I+ ++ G I E GTH +LM+ KG
Sbjct: 676 NSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGC 735
Query: 527 YHKLVTSGKETKE 539
Y +V + + E
Sbjct: 736 YWAMVQAPADAPE 748
Score = 199 bits (486), Expect = 4e-50
Identities = 151/507 (29%), Positives = 235/507 (46%), Gaps = 27/507 (5%)
Query: 644 TVGSIAAFIQGACFPVFALLLGYTSGEIGYFDRESNTVGAVCARLSGDTAEVQGATGLRI 703
T+G + + +QG VF +L E +F + N G + +R++ DT+ + + +
Sbjct: 252 TMGHVHSHLQGE---VFGAVLRQ---ETEFF--QQNQTGNIMSRVTEDTSTLSDSLSENL 303
Query: 704 GLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESA 763
L L + + + LT+V+ LPL+ G Q + RE++ +
Sbjct: 304 SLFLWYLVRGLCLLGIMLWGSVSLTMVTLVTLPLLFLLPKKVGKWYQLLEVQVRESLAKS 363
Query: 764 TAIATEAVVSIKTVQSLGIESLFITRFQDALIDACAAVVKKS------RWRGLVLGLCIY 817
+ +A EA+ ++ TV+S E +F++ L + K++ W + G+ +
Sbjct: 364 SQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLK 423
Query: 818 VPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXXXXMYGAYMLGQSLVYAPSFNSAKTCGAR 877
V +L G LV G M L L P A +
Sbjct: 424 VGIL------YIGGQLVTSGAVSSGNLVTFVLYQMQFTQALEVLLSIYPRVQKAVGSSEK 477
Query: 878 ILSIINREPRIRTVDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTV 937
I ++R PR L G DV F+YP R ++L+G+ + G+
Sbjct: 478 IFEYLDRTPRCPPSGLLTPLH---LEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVT 534
Query: 938 ALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDR 997
ALVG +G GKSTV L+Q Y PT G + LDG + + L +Q+ V QEP +F R
Sbjct: 535 ALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQ-YEHRYLHRQVAAVGQEPQVFGR 593
Query: 998 TLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVC 1057
+L ENIAYG ++KPTM+E H+FI LP+GY+T +Q V
Sbjct: 594 SLQENIAYG-LTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVGEAGSQLSGGQQQAVA 652
Query: 1058 IARALIRSPRLLLLDEATSALDANSERAVTEALDHAAK--GRTCITIAHRLTTIKDADII 1115
+ARALIR P +L+LD+ATSALDANS+ V + L + + R+ + I L+ ++ AD I
Sbjct: 653 LARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHI 712
Query: 1116 CVLDKGKIVEKGNHAELIGLKGHYWQL 1142
L+ G I E G H +L+ KG YW +
Sbjct: 713 LFLEGGAIREGGTHQQLMEKKGCYWAM 739
>BC064384-1|AAH64384.1| 769|Homo sapiens ABCB9 protein protein.
Length = 769
Score = 249 bits (609), Expect = 5e-65
Identities = 156/495 (31%), Positives = 257/495 (51%), Gaps = 21/495 (4%)
Query: 44 IRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAV-VSNLVGTSIICLC 102
+R +++ Q+ ++FD + +L S+++ + + + + + + V + N V + + +
Sbjct: 261 LRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVF 320
Query: 103 TAFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTVV 162
F L W+L+L P +M S Y + S + ++A AEE + ++KTV
Sbjct: 321 M-FSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVR 379
Query: 163 AFGGENIEVQRYKSLLEPAEISGSRRG---LFTGLGNGFNWVLTYSLNTIGFMYGTRLII 219
+F E E + Y L+ + ++ G+G +L ++ + YG L+I
Sbjct: 380 SFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLT-LLVVQVSIL--YYGGHLVI 436
Query: 220 EDANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPK 279
+ +II F + +S+ + GAA +F +D+ P
Sbjct: 437 SGQMTSGNLIAFII-----YEFVLGDCMESVGSVYSGL---MQGVGAAEKVFEFIDRQPT 488
Query: 280 IDCLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKS 339
+ + + +P + G + E+V F+Y +R ++L+ S + PG+ ALVG SG GKS
Sbjct: 489 M--VHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKS 546
Query: 340 TILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPE 399
+ + +L+ Y G V LDG+ + + +L + +V QEPVLF +I DNI+ G P
Sbjct: 547 SCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPT 606
Query: 400 ATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLL 459
E V A+ A AH FI L +GY T GE+GA LSGGQKQR+A+AR+L+R P VL+L
Sbjct: 607 VPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLIL 666
Query: 460 DEATSALDPHSE---KQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGT 516
DEATSALD SE Q+Q A+ T L ++HRLST+ + H I+ +D+G +++QGT
Sbjct: 667 DEATSALDAESEYLSPQIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGT 726
Query: 517 HVELMKAKGFYHKLV 531
H +L+ G Y KLV
Sbjct: 727 HQQLLAQGGLYAKLV 741
Score = 200 bits (489), Expect = 2e-50
Identities = 157/527 (29%), Positives = 248/527 (47%), Gaps = 40/527 (7%)
Query: 643 LTVGS-IAAFIQGACFP-VFA---------LLLGYTSGEIGYFDRESNTVGAVCARLSGD 691
L +GS AA I+G F +FA L S E +FD N G + +RL+ D
Sbjct: 235 LAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDE--NRTGDLISRLTSD 292
Query: 692 TAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGSIWLEGIMSQK 751
T V I + L+ VT + S +W+L+LV+ P+++ + G ++
Sbjct: 293 TTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKR 352
Query: 752 SQQDEREAMESATAIATEAVVSIKTVQSLGIES----LFITRFQDA--LIDACAAVVKKS 805
++ + A+ A+ A E + ++KTV+S E +++ + Q L AA
Sbjct: 353 LSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYY 412
Query: 806 RWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXXXX-MYGAYMLGQSLVY 864
W GL + L+ S + YG LV G + G M VY
Sbjct: 413 VWGS---GLTL---LVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVY 466
Query: 865 APSFNSAKTCGARILSIINREPRIRTVDGLNDKQDWSASGNFSINDVEFSYPTRAHQMIL 924
+ ++ I+R+P + L G +V F+Y TR H +L
Sbjct: 467 SGLMQGVGAA-EKVFEFIDRQPTMVHDGSLAPDH---LEGRVDFENVTFTYRTRPHTQVL 522
Query: 925 KGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQ 984
+ + + GK ALVG SG GKS+ + +++ FY G + LDG I+ + L +
Sbjct: 523 QNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPIS-AYDHKYLHRV 581
Query: 985 LGVVQQEPILFDRTLAENIAYGDNSRKPTM--DEXXXXXXXXXXHNFIVSLPKGYETNXX 1042
+ +V QEP+LF R++ +NI+YG PT+ + H FI+ L GY T
Sbjct: 582 ISLVSQEPVLFARSITDNISYG----LPTVPFEMVVEAAQKANAHGFIMELQDGYSTETG 637
Query: 1043 XXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSE---RAVTEALDHAAKGRTC 1099
KQRV +ARAL+R+P +L+LDEATSALDA SE + +A+ + T
Sbjct: 638 EKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLSPQIQQAIHGNLQKHTV 697
Query: 1100 ITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSKQQ 1146
+ IAHRL+T++ A +I VLDKG++V++G H +L+ G Y +L ++Q
Sbjct: 698 LIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQ 744
>L21208-1|AAC12906.1| 748|Homo sapiens peptide transporter protein.
Length = 748
Score = 248 bits (608), Expect = 7e-65
Identities = 149/493 (30%), Positives = 260/493 (52%), Gaps = 15/493 (3%)
Query: 51 AVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAVVSNLVGTSIICLCTAFPLGWK 110
AVLRQ+ +F + N+ S+++E+ L + + E L++ + + L
Sbjct: 267 AVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGSVS 326
Query: 111 LALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAFGGENIE 170
L + + +P + + + ++ ES +++ + A E L ++ TV +F E E
Sbjct: 327 LTMVTLVTLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGE 386
Query: 171 VQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMY-GTRLIIEDANKPDDER 229
Q+++ L+ + + + + N + ++ L +G +Y G +L+ A +
Sbjct: 387 AQKFREKLQEIKTLNQKEAVAYAV-NSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLV 445
Query: 230 TYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKIDCLSEAGSS 289
T+++ + F+ A + + P ++ A G++ IF LD+ P+ C +
Sbjct: 446 TFVL---YQMQFT--QAVEVLLSIYPRVQ---KAVGSSEKIFEYLDRTPR--CPPSGLLT 495
Query: 290 PRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLY 349
P + G + +DV F+YP+R D+ +L+G + ++PGE ALVG +G GKST+ LLQ LY
Sbjct: 496 PLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLY 555
Query: 350 DPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPE-ATSEDVYRV 408
P G + LDG+ L +L + VGQEP +F ++ +NIA G + T E++
Sbjct: 556 QPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAA 615
Query: 409 AEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDP 468
A + AH FI LP GY+T + E G+ LSGGQ+Q +A+AR+L+R+P VL+LD+ATSALD
Sbjct: 616 AVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDA 675
Query: 469 HSEKQVQAALDRA--SVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGF 526
+S+ QV+ L + R+ L ++ LS + I+ ++ G I E GTH +LM+ KG
Sbjct: 676 NSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGC 735
Query: 527 YHKLVTSGKETKE 539
Y +V + + E
Sbjct: 736 YWAMVQAPADAPE 748
Score = 198 bits (484), Expect = 7e-50
Identities = 150/507 (29%), Positives = 235/507 (46%), Gaps = 27/507 (5%)
Query: 644 TVGSIAAFIQGACFPVFALLLGYTSGEIGYFDRESNTVGAVCARLSGDTAEVQGATGLRI 703
T+G + + +QG VF +L E +F + N G + +R++ DT+ + + +
Sbjct: 252 TMGHVHSHLQGE---VFGAVLRQ---ETEFF--QQNQTGNIMSRVTEDTSTLSDSLSENL 303
Query: 704 GLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESA 763
L L + + + LT+V+ LPL+ G Q + RE++ +
Sbjct: 304 SLFLWYLVRGLCLLGIMLWGSVSLTMVTLVTLPLLFLLPKKVGKWYQLLEVQVRESLAKS 363
Query: 764 TAIATEAVVSIKTVQSLGIESLFITRFQDALIDACAAVVKKS------RWRGLVLGLCIY 817
+ +A EA+ ++ TV+S E +F++ L + K++ W + G+ +
Sbjct: 364 SQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLK 423
Query: 818 VPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXXXXMYGAYMLGQSLVYAPSFNSAKTCGAR 877
V +L G LV G M + L P A +
Sbjct: 424 VGIL------YIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEK 477
Query: 878 ILSIINREPRIRTVDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTV 937
I ++R PR L G DV F+YP R ++L+G+ + G+
Sbjct: 478 IFEYLDRTPRCPPSGLLTPLH---LEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVT 534
Query: 938 ALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDR 997
ALVG +G GKSTV L+Q Y PT G + LDG + + L +Q+ V QEP +F R
Sbjct: 535 ALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQ-YEHRYLHRQVAAVGQEPQVFGR 593
Query: 998 TLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVC 1057
+L ENIAYG ++KPTM+E H+FI LP+GY+T +Q V
Sbjct: 594 SLQENIAYG-LTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVA 652
Query: 1058 IARALIRSPRLLLLDEATSALDANSERAVTEALDHAAK--GRTCITIAHRLTTIKDADII 1115
+ARALIR P +L+LD+ATSALDANS+ V + L + + R+ + I L+ ++ AD I
Sbjct: 653 LARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHI 712
Query: 1116 CVLDKGKIVEKGNHAELIGLKGHYWQL 1142
L+ G I E G H +L+ KG YW +
Sbjct: 713 LFLEGGAIREGGTHQQLMEKKGCYWAM 739
>X87344-5|CAA60785.1| 748|Homo sapiens TAP1 protein.
Length = 748
Score = 248 bits (607), Expect = 9e-65
Identities = 149/493 (30%), Positives = 260/493 (52%), Gaps = 15/493 (3%)
Query: 51 AVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAVVSNLVGTSIICLCTAFPLGWK 110
AVLRQ+ +F + N+ S+++E+ L + + E L++ + + L
Sbjct: 267 AVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGSVS 326
Query: 111 LALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAFGGENIE 170
L + + +P + + + ++ ES +++ + A E L ++ TV +F E E
Sbjct: 327 LTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGE 386
Query: 171 VQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMY-GTRLIIEDANKPDDER 229
Q+++ L+ + + + + N + ++ L +G +Y G +L+ A +
Sbjct: 387 AQKFREKLQEIKTLNQKEAVAYAV-NSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLV 445
Query: 230 TYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKIDCLSEAGSS 289
T+++ + F+ A + + P ++ A G++ IF LD+ P+ C +
Sbjct: 446 TFVL---YQMQFT--QAVEVLLSIYPRVQ---KAVGSSEKIFEYLDRTPR--CPPSGLLT 495
Query: 290 PRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLY 349
P + G + +DV F+YP+R D+ +L+G + ++PGE ALVG +G GKST+ LLQ LY
Sbjct: 496 PLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLY 555
Query: 350 DPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPE-ATSEDVYRV 408
P G + LDG+ L +L + VGQEP +F ++ +NIA G + T E++
Sbjct: 556 QPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAA 615
Query: 409 AEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDP 468
A + AH FI LP GY+T + E G+ LSGGQ+Q +A+AR+L+R+P VL+LD+ATSALD
Sbjct: 616 AVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDA 675
Query: 469 HSEKQVQAALDRA--SVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGF 526
+S+ QV+ L + R+ L ++ LS + I+ ++ G I E GTH +LM+ KG
Sbjct: 676 NSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGC 735
Query: 527 YHKLVTSGKETKE 539
Y +V + + E
Sbjct: 736 YWAMVQAPADAPE 748
Score = 198 bits (483), Expect = 9e-50
Identities = 150/507 (29%), Positives = 235/507 (46%), Gaps = 27/507 (5%)
Query: 644 TVGSIAAFIQGACFPVFALLLGYTSGEIGYFDRESNTVGAVCARLSGDTAEVQGATGLRI 703
T+G + + +QG VF +L E +F + N G + +R++ DT+ + + +
Sbjct: 252 TMGHVHSHLQGE---VFGAVLRQ---ETEFF--QQNQTGNIMSRVTEDTSTLSDSLSENL 303
Query: 704 GLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESA 763
L L + + + LT+V+ LPL+ G Q + RE++ +
Sbjct: 304 SLFLWYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKS 363
Query: 764 TAIATEAVVSIKTVQSLGIESLFITRFQDALIDACAAVVKKS------RWRGLVLGLCIY 817
+ +A EA+ ++ TV+S E +F++ L + K++ W + G+ +
Sbjct: 364 SQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLK 423
Query: 818 VPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXXXXMYGAYMLGQSLVYAPSFNSAKTCGAR 877
V +L G LV G M + L P A +
Sbjct: 424 VGIL------YIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEK 477
Query: 878 ILSIINREPRIRTVDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTV 937
I ++R PR L G DV F+YP R ++L+G+ + G+
Sbjct: 478 IFEYLDRTPRCPPSGLLTPLH---LEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVT 534
Query: 938 ALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDR 997
ALVG +G GKSTV L+Q Y PT G + LDG + + L +Q+ V QEP +F R
Sbjct: 535 ALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQ-YEHRYLHRQVAAVGQEPQVFGR 593
Query: 998 TLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVC 1057
+L ENIAYG ++KPTM+E H+FI LP+GY+T +Q V
Sbjct: 594 SLQENIAYG-LTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVA 652
Query: 1058 IARALIRSPRLLLLDEATSALDANSERAVTEALDHAAK--GRTCITIAHRLTTIKDADII 1115
+ARALIR P +L+LD+ATSALDANS+ V + L + + R+ + I L+ ++ AD I
Sbjct: 653 LARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHI 712
Query: 1116 CVLDKGKIVEKGNHAELIGLKGHYWQL 1142
L+ G I E G H +L+ KG YW +
Sbjct: 713 LFLEGGAIREGGTHQQLMEKKGCYWAM 739
>X66401-2|CAA47025.1| 748|Homo sapiens ABC-transporter protein.
Length = 748
Score = 248 bits (607), Expect = 9e-65
Identities = 149/493 (30%), Positives = 260/493 (52%), Gaps = 15/493 (3%)
Query: 51 AVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAVVSNLVGTSIICLCTAFPLGWK 110
AVLRQ+ +F + N+ S+++E+ L + + E L++ + + L
Sbjct: 267 AVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGSVS 326
Query: 111 LALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAFGGENIE 170
L + + +P + + + ++ ES +++ + A E L ++ TV +F E E
Sbjct: 327 LTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGE 386
Query: 171 VQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMY-GTRLIIEDANKPDDER 229
Q+++ L+ + + + + N + ++ L +G +Y G +L+ A +
Sbjct: 387 AQKFREKLQEIKTLNQKEAVAYAV-NSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLV 445
Query: 230 TYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKIDCLSEAGSS 289
T+++ + F+ A + + P ++ A G++ IF LD+ P+ C +
Sbjct: 446 TFVL---YQMQFT--QAVEVLLSIYPRVQ---KAVGSSEKIFEYLDRTPR--CPPSGLLT 495
Query: 290 PRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLY 349
P + G + +DV F+YP+R D+ +L+G + ++PGE ALVG +G GKST+ LLQ LY
Sbjct: 496 PLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLY 555
Query: 350 DPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPE-ATSEDVYRV 408
P G + LDG+ L +L + VGQEP +F ++ +NIA G + T E++
Sbjct: 556 QPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAA 615
Query: 409 AEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDP 468
A + AH FI LP GY+T + E G+ LSGGQ+Q +A+AR+L+R+P VL+LD+ATSALD
Sbjct: 616 AVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDA 675
Query: 469 HSEKQVQAALDRA--SVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGF 526
+S+ QV+ L + R+ L ++ LS + I+ ++ G I E GTH +LM+ KG
Sbjct: 676 NSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGC 735
Query: 527 YHKLVTSGKETKE 539
Y +V + + E
Sbjct: 736 YWAMVQAPADAPE 748
Score = 198 bits (483), Expect = 9e-50
Identities = 150/507 (29%), Positives = 235/507 (46%), Gaps = 27/507 (5%)
Query: 644 TVGSIAAFIQGACFPVFALLLGYTSGEIGYFDRESNTVGAVCARLSGDTAEVQGATGLRI 703
T+G + + +QG VF +L E +F + N G + +R++ DT+ + + +
Sbjct: 252 TMGHVHSHLQGE---VFGAVLRQ---ETEFF--QQNQTGNIMSRVTEDTSTLSDSLSENL 303
Query: 704 GLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESA 763
L L + + + LT+V+ LPL+ G Q + RE++ +
Sbjct: 304 SLFLWYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKS 363
Query: 764 TAIATEAVVSIKTVQSLGIESLFITRFQDALIDACAAVVKKS------RWRGLVLGLCIY 817
+ +A EA+ ++ TV+S E +F++ L + K++ W + G+ +
Sbjct: 364 SQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLK 423
Query: 818 VPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXXXXMYGAYMLGQSLVYAPSFNSAKTCGAR 877
V +L G LV G M + L P A +
Sbjct: 424 VGIL------YIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEK 477
Query: 878 ILSIINREPRIRTVDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTV 937
I ++R PR L G DV F+YP R ++L+G+ + G+
Sbjct: 478 IFEYLDRTPRCPPSGLLTPLH---LEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVT 534
Query: 938 ALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDR 997
ALVG +G GKSTV L+Q Y PT G + LDG + + L +Q+ V QEP +F R
Sbjct: 535 ALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQ-YEHRYLHRQVAAVGQEPQVFGR 593
Query: 998 TLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVC 1057
+L ENIAYG ++KPTM+E H+FI LP+GY+T +Q V
Sbjct: 594 SLQENIAYG-LTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVA 652
Query: 1058 IARALIRSPRLLLLDEATSALDANSERAVTEALDHAAK--GRTCITIAHRLTTIKDADII 1115
+ARALIR P +L+LD+ATSALDANS+ V + L + + R+ + I L+ ++ AD I
Sbjct: 653 LARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHI 712
Query: 1116 CVLDKGKIVEKGNHAELIGLKGHYWQL 1142
L+ G I E G H +L+ KG YW +
Sbjct: 713 LFLEGGAIREGGTHQQLMEKKGCYWAM 739
>X57522-1|CAA40741.1| 808|Homo sapiens peptide transporter protein.
Length = 808
Score = 248 bits (607), Expect = 9e-65
Identities = 149/493 (30%), Positives = 260/493 (52%), Gaps = 15/493 (3%)
Query: 51 AVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAVVSNLVGTSIICLCTAFPLGWK 110
AVLRQ+ +F + N+ S+++E+ L + + E L++ + + L
Sbjct: 327 AVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGSVS 386
Query: 111 LALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAFGGENIE 170
L + + +P + + + ++ ES +++ + A E L ++ TV +F E E
Sbjct: 387 LTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGE 446
Query: 171 VQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMY-GTRLIIEDANKPDDER 229
Q+++ L+ + + + + N + ++ L +G +Y G +L+ A +
Sbjct: 447 AQKFREKLQEIKTLNQKEAVAYAV-NSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLV 505
Query: 230 TYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKIDCLSEAGSS 289
T+++ + F+ A + + P ++ A G++ IF LD+ P+ C +
Sbjct: 506 TFVL---YQMQFT--QAVEVLLSIYPRVQ---KAVGSSEKIFEYLDRTPR--CPPSGLLT 555
Query: 290 PRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLY 349
P + G + +DV F+YP+R D+ +L+G + ++PGE ALVG +G GKST+ LLQ LY
Sbjct: 556 PLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLY 615
Query: 350 DPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPE-ATSEDVYRV 408
P G + LDG+ L +L + VGQEP +F ++ +NIA G + T E++
Sbjct: 616 QPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAA 675
Query: 409 AEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDP 468
A + AH FI LP GY+T + E G+ LSGGQ+Q +A+AR+L+R+P VL+LD+ATSALD
Sbjct: 676 AVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDA 735
Query: 469 HSEKQVQAALDRA--SVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGF 526
+S+ QV+ L + R+ L ++ LS + I+ ++ G I E GTH +LM+ KG
Sbjct: 736 NSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGC 795
Query: 527 YHKLVTSGKETKE 539
Y +V + + E
Sbjct: 796 YWAMVQAPADAPE 808
Score = 198 bits (483), Expect = 9e-50
Identities = 150/507 (29%), Positives = 235/507 (46%), Gaps = 27/507 (5%)
Query: 644 TVGSIAAFIQGACFPVFALLLGYTSGEIGYFDRESNTVGAVCARLSGDTAEVQGATGLRI 703
T+G + + +QG VF +L E +F + N G + +R++ DT+ + + +
Sbjct: 312 TMGHVHSHLQGE---VFGAVLRQ---ETEFF--QQNQTGNIMSRVTEDTSTLSDSLSENL 363
Query: 704 GLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESA 763
L L + + + LT+V+ LPL+ G Q + RE++ +
Sbjct: 364 SLFLWYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKS 423
Query: 764 TAIATEAVVSIKTVQSLGIESLFITRFQDALIDACAAVVKKS------RWRGLVLGLCIY 817
+ +A EA+ ++ TV+S E +F++ L + K++ W + G+ +
Sbjct: 424 SQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLK 483
Query: 818 VPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXXXXMYGAYMLGQSLVYAPSFNSAKTCGAR 877
V +L G LV G M + L P A +
Sbjct: 484 VGIL------YIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEK 537
Query: 878 ILSIINREPRIRTVDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTV 937
I ++R PR L G DV F+YP R ++L+G+ + G+
Sbjct: 538 IFEYLDRTPRCPPSGLLTPLH---LEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVT 594
Query: 938 ALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDR 997
ALVG +G GKSTV L+Q Y PT G + LDG + + L +Q+ V QEP +F R
Sbjct: 595 ALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQ-YEHRYLHRQVAAVGQEPQVFGR 653
Query: 998 TLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVC 1057
+L ENIAYG ++KPTM+E H+FI LP+GY+T +Q V
Sbjct: 654 SLQENIAYG-LTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVA 712
Query: 1058 IARALIRSPRLLLLDEATSALDANSERAVTEALDHAAK--GRTCITIAHRLTTIKDADII 1115
+ARALIR P +L+LD+ATSALDANS+ V + L + + R+ + I L+ ++ AD I
Sbjct: 713 LARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHI 772
Query: 1116 CVLDKGKIVEKGNHAELIGLKGHYWQL 1142
L+ G I E G H +L+ KG YW +
Sbjct: 773 LFLEGGAIREGGTHQQLMEKKGCYWAM 799
>L21204-1|AAC12902.1| 748|Homo sapiens peptide transporter protein.
Length = 748
Score = 248 bits (607), Expect = 9e-65
Identities = 149/493 (30%), Positives = 260/493 (52%), Gaps = 15/493 (3%)
Query: 51 AVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAVVSNLVGTSIICLCTAFPLGWK 110
AVLRQ+ +F + N+ S+++E+ L + + E L++ + + L
Sbjct: 267 AVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGSVS 326
Query: 111 LALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAFGGENIE 170
L + + +P + + + ++ ES +++ + A E L ++ TV +F E E
Sbjct: 327 LTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGE 386
Query: 171 VQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMY-GTRLIIEDANKPDDER 229
Q+++ L+ + + + + N + ++ L +G +Y G +L+ A +
Sbjct: 387 AQKFREKLQEIKTLNQKEAVAYAV-NSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLV 445
Query: 230 TYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKIDCLSEAGSS 289
T+++ + F+ A + + P ++ A G++ IF LD+ P+ C +
Sbjct: 446 TFVL---YQMQFT--QAVEVLLSIYPRVQ---KAVGSSEKIFEYLDRTPR--CPPSGLLT 495
Query: 290 PRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLY 349
P + G + +DV F+YP+R D+ +L+G + ++PGE ALVG +G GKST+ LLQ LY
Sbjct: 496 PLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLY 555
Query: 350 DPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPE-ATSEDVYRV 408
P G + LDG+ L +L + VGQEP +F ++ +NIA G + T E++
Sbjct: 556 QPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAA 615
Query: 409 AEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDP 468
A + AH FI LP GY+T + E G+ LSGGQ+Q +A+AR+L+R+P VL+LD+ATSALD
Sbjct: 616 AVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDA 675
Query: 469 HSEKQVQAALDRA--SVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGF 526
+S+ QV+ L + R+ L ++ LS + I+ ++ G I E GTH +LM+ KG
Sbjct: 676 NSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGC 735
Query: 527 YHKLVTSGKETKE 539
Y +V + + E
Sbjct: 736 YWAMVQAPADAPE 748
Score = 198 bits (483), Expect = 9e-50
Identities = 150/507 (29%), Positives = 235/507 (46%), Gaps = 27/507 (5%)
Query: 644 TVGSIAAFIQGACFPVFALLLGYTSGEIGYFDRESNTVGAVCARLSGDTAEVQGATGLRI 703
T+G + + +QG VF +L E +F + N G + +R++ DT+ + + +
Sbjct: 252 TMGHVHSHLQGE---VFGAVLRQ---ETEFF--QQNQTGNIMSRVTEDTSTLSDSLSENL 303
Query: 704 GLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESA 763
L L + + + LT+V+ LPL+ G Q + RE++ +
Sbjct: 304 SLFLWYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKS 363
Query: 764 TAIATEAVVSIKTVQSLGIESLFITRFQDALIDACAAVVKKS------RWRGLVLGLCIY 817
+ +A EA+ ++ TV+S E +F++ L + K++ W + G+ +
Sbjct: 364 SQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLK 423
Query: 818 VPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXXXXMYGAYMLGQSLVYAPSFNSAKTCGAR 877
V +L G LV G M + L P A +
Sbjct: 424 VGIL------YIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEK 477
Query: 878 ILSIINREPRIRTVDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTV 937
I ++R PR L G DV F+YP R ++L+G+ + G+
Sbjct: 478 IFEYLDRTPRCPPSGLLTPLH---LEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVT 534
Query: 938 ALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDR 997
ALVG +G GKSTV L+Q Y PT G + LDG + + L +Q+ V QEP +F R
Sbjct: 535 ALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQ-YEHRYLHRQVAAVGQEPQVFGR 593
Query: 998 TLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVC 1057
+L ENIAYG ++KPTM+E H+FI LP+GY+T +Q V
Sbjct: 594 SLQENIAYG-LTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVA 652
Query: 1058 IARALIRSPRLLLLDEATSALDANSERAVTEALDHAAK--GRTCITIAHRLTTIKDADII 1115
+ARALIR P +L+LD+ATSALDANS+ V + L + + R+ + I L+ ++ AD I
Sbjct: 653 LARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHI 712
Query: 1116 CVLDKGKIVEKGNHAELIGLKGHYWQL 1142
L+ G I E G H +L+ KG YW +
Sbjct: 713 LFLEGGAIREGGTHQQLMEKKGCYWAM 739
>BX088556-4|CAM26263.1| 808|Homo sapiens transporter 1 ATP-binding
cassette sub-family B (MDR/TAP) protein.
Length = 808
Score = 248 bits (607), Expect = 9e-65
Identities = 149/493 (30%), Positives = 260/493 (52%), Gaps = 15/493 (3%)
Query: 51 AVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAVVSNLVGTSIICLCTAFPLGWK 110
AVLRQ+ +F + N+ S+++E+ L + + E L++ + + L
Sbjct: 327 AVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGSVS 386
Query: 111 LALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAFGGENIE 170
L + + +P + + + ++ ES +++ + A E L ++ TV +F E E
Sbjct: 387 LTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGE 446
Query: 171 VQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMY-GTRLIIEDANKPDDER 229
Q+++ L+ + + + + N + ++ L +G +Y G +L+ A +
Sbjct: 447 AQKFREKLQEIKTLNQKEAVAYAV-NSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLV 505
Query: 230 TYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKIDCLSEAGSS 289
T+++ + F+ A + + P ++ A G++ IF LD+ P+ C +
Sbjct: 506 TFVL---YQMQFT--QAVEVLLSIYPRVQ---KAVGSSEKIFEYLDRTPR--CPPSGLLT 555
Query: 290 PRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLY 349
P + G + +DV F+YP+R D+ +L+G + ++PGE ALVG +G GKST+ LLQ LY
Sbjct: 556 PLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLY 615
Query: 350 DPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPE-ATSEDVYRV 408
P G + LDG+ L +L + VGQEP +F ++ +NIA G + T E++
Sbjct: 616 QPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAA 675
Query: 409 AEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDP 468
A + AH FI LP GY+T + E G+ LSGGQ+Q +A+AR+L+R+P VL+LD+ATSALD
Sbjct: 676 AVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDA 735
Query: 469 HSEKQVQAALDRA--SVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGF 526
+S+ QV+ L + R+ L ++ LS + I+ ++ G I E GTH +LM+ KG
Sbjct: 736 NSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGC 795
Query: 527 YHKLVTSGKETKE 539
Y +V + + E
Sbjct: 796 YWAMVQAPADAPE 808
Score = 198 bits (483), Expect = 9e-50
Identities = 150/507 (29%), Positives = 235/507 (46%), Gaps = 27/507 (5%)
Query: 644 TVGSIAAFIQGACFPVFALLLGYTSGEIGYFDRESNTVGAVCARLSGDTAEVQGATGLRI 703
T+G + + +QG VF +L E +F + N G + +R++ DT+ + + +
Sbjct: 312 TMGHVHSHLQGE---VFGAVLRQ---ETEFF--QQNQTGNIMSRVTEDTSTLSDSLSENL 363
Query: 704 GLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESA 763
L L + + + LT+V+ LPL+ G Q + RE++ +
Sbjct: 364 SLFLWYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKS 423
Query: 764 TAIATEAVVSIKTVQSLGIESLFITRFQDALIDACAAVVKKS------RWRGLVLGLCIY 817
+ +A EA+ ++ TV+S E +F++ L + K++ W + G+ +
Sbjct: 424 SQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLK 483
Query: 818 VPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXXXXMYGAYMLGQSLVYAPSFNSAKTCGAR 877
V +L G LV G M + L P A +
Sbjct: 484 VGIL------YIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEK 537
Query: 878 ILSIINREPRIRTVDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTV 937
I ++R PR L G DV F+YP R ++L+G+ + G+
Sbjct: 538 IFEYLDRTPRCPPSGLLTPLH---LEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVT 594
Query: 938 ALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDR 997
ALVG +G GKSTV L+Q Y PT G + LDG + + L +Q+ V QEP +F R
Sbjct: 595 ALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQ-YEHRYLHRQVAAVGQEPQVFGR 653
Query: 998 TLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVC 1057
+L ENIAYG ++KPTM+E H+FI LP+GY+T +Q V
Sbjct: 654 SLQENIAYG-LTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVA 712
Query: 1058 IARALIRSPRLLLLDEATSALDANSERAVTEALDHAAK--GRTCITIAHRLTTIKDADII 1115
+ARALIR P +L+LD+ATSALDANS+ V + L + + R+ + I L+ ++ AD I
Sbjct: 713 LARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHI 772
Query: 1116 CVLDKGKIVEKGNHAELIGLKGHYWQL 1142
L+ G I E G H +L+ KG YW +
Sbjct: 773 LFLEGGAIREGGTHQQLMEKKGCYWAM 799
>BC014081-1|AAH14081.1| 808|Homo sapiens transporter 1, ATP-binding
cassette, sub-family B (MDR/TAP) protein.
Length = 808
Score = 248 bits (607), Expect = 9e-65
Identities = 149/493 (30%), Positives = 260/493 (52%), Gaps = 15/493 (3%)
Query: 51 AVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAVVSNLVGTSIICLCTAFPLGWK 110
AVLRQ+ +F + N+ S+++E+ L + + E L++ + + L
Sbjct: 327 AVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGSVS 386
Query: 111 LALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAFGGENIE 170
L + + +P + + + ++ ES +++ + A E L ++ TV +F E E
Sbjct: 387 LTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGE 446
Query: 171 VQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMY-GTRLIIEDANKPDDER 229
Q+++ L+ + + + + N + ++ L +G +Y G +L+ A +
Sbjct: 447 AQKFREKLQEIKTLNQKEAVAYAV-NSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLV 505
Query: 230 TYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKIDCLSEAGSS 289
T+++ + F+ A + + P ++ A G++ IF LD+ P+ C +
Sbjct: 506 TFVL---YQMQFT--QAVEVLLSIYPRVQ---KAVGSSEKIFEYLDRTPR--CPPSGLLT 555
Query: 290 PRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLY 349
P + G + +DV F+YP+R D+ +L+G + ++PGE ALVG +G GKST+ LLQ LY
Sbjct: 556 PLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLY 615
Query: 350 DPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPE-ATSEDVYRV 408
P G + LDG+ L +L + VGQEP +F ++ +NIA G + T E++
Sbjct: 616 QPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAA 675
Query: 409 AEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDP 468
A + AH FI LP GY+T + E G+ LSGGQ+Q +A+AR+L+R+P VL+LD+ATSALD
Sbjct: 676 AVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDA 735
Query: 469 HSEKQVQAALDRA--SVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGF 526
+S+ QV+ L + R+ L ++ LS + I+ ++ G I E GTH +LM+ KG
Sbjct: 736 NSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGC 795
Query: 527 YHKLVTSGKETKE 539
Y +V + + E
Sbjct: 796 YWAMVQAPADAPE 808
Score = 198 bits (483), Expect = 9e-50
Identities = 150/507 (29%), Positives = 235/507 (46%), Gaps = 27/507 (5%)
Query: 644 TVGSIAAFIQGACFPVFALLLGYTSGEIGYFDRESNTVGAVCARLSGDTAEVQGATGLRI 703
T+G + + +QG VF +L E +F + N G + +R++ DT+ + + +
Sbjct: 312 TMGHVHSHLQGE---VFGAVLRQ---ETEFF--QQNQTGNIMSRVTEDTSTLSDSLSENL 363
Query: 704 GLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESA 763
L L + + + LT+V+ LPL+ G Q + RE++ +
Sbjct: 364 SLFLWYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKS 423
Query: 764 TAIATEAVVSIKTVQSLGIESLFITRFQDALIDACAAVVKKS------RWRGLVLGLCIY 817
+ +A EA+ ++ TV+S E +F++ L + K++ W + G+ +
Sbjct: 424 SQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLK 483
Query: 818 VPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXXXXMYGAYMLGQSLVYAPSFNSAKTCGAR 877
V +L G LV G M + L P A +
Sbjct: 484 VGIL------YIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEK 537
Query: 878 ILSIINREPRIRTVDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTV 937
I ++R PR L G DV F+YP R ++L+G+ + G+
Sbjct: 538 IFEYLDRTPRCPPSGLLTPLH---LEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVT 594
Query: 938 ALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDR 997
ALVG +G GKSTV L+Q Y PT G + LDG + + L +Q+ V QEP +F R
Sbjct: 595 ALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQ-YEHRYLHRQVAAVGQEPQVFGR 653
Query: 998 TLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVC 1057
+L ENIAYG ++KPTM+E H+FI LP+GY+T +Q V
Sbjct: 654 SLQENIAYG-LTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVA 712
Query: 1058 IARALIRSPRLLLLDEATSALDANSERAVTEALDHAAK--GRTCITIAHRLTTIKDADII 1115
+ARALIR P +L+LD+ATSALDANS+ V + L + + R+ + I L+ ++ AD I
Sbjct: 713 LARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHI 772
Query: 1116 CVLDKGKIVEKGNHAELIGLKGHYWQL 1142
L+ G I E G H +L+ KG YW +
Sbjct: 773 LFLEGGAIREGGTHQQLMEKKGCYWAM 799
>AL935043-6|CAI18626.1| 808|Homo sapiens transporter 1, ATP-binding
cassette, sub-family Bpha protein.
Length = 808
Score = 248 bits (607), Expect = 9e-65
Identities = 149/493 (30%), Positives = 260/493 (52%), Gaps = 15/493 (3%)
Query: 51 AVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAVVSNLVGTSIICLCTAFPLGWK 110
AVLRQ+ +F + N+ S+++E+ L + + E L++ + + L
Sbjct: 327 AVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGSVS 386
Query: 111 LALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAFGGENIE 170
L + + +P + + + ++ ES +++ + A E L ++ TV +F E E
Sbjct: 387 LTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGE 446
Query: 171 VQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMY-GTRLIIEDANKPDDER 229
Q+++ L+ + + + + N + ++ L +G +Y G +L+ A +
Sbjct: 447 AQKFREKLQEIKTLNQKEAVAYAV-NSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLV 505
Query: 230 TYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKIDCLSEAGSS 289
T+++ + F+ A + + P ++ A G++ IF LD+ P+ C +
Sbjct: 506 TFVL---YQMQFT--QAVEVLLSIYPRVQ---KAVGSSEKIFEYLDRTPR--CPPSGLLT 555
Query: 290 PRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLY 349
P + G + +DV F+YP+R D+ +L+G + ++PGE ALVG +G GKST+ LLQ LY
Sbjct: 556 PLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLY 615
Query: 350 DPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPE-ATSEDVYRV 408
P G + LDG+ L +L + VGQEP +F ++ +NIA G + T E++
Sbjct: 616 QPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAA 675
Query: 409 AEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDP 468
A + AH FI LP GY+T + E G+ LSGGQ+Q +A+AR+L+R+P VL+LD+ATSALD
Sbjct: 676 AVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDA 735
Query: 469 HSEKQVQAALDRA--SVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGF 526
+S+ QV+ L + R+ L ++ LS + I+ ++ G I E GTH +LM+ KG
Sbjct: 736 NSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGC 795
Query: 527 YHKLVTSGKETKE 539
Y +V + + E
Sbjct: 796 YWAMVQAPADAPE 808
Score = 198 bits (483), Expect = 9e-50
Identities = 150/507 (29%), Positives = 235/507 (46%), Gaps = 27/507 (5%)
Query: 644 TVGSIAAFIQGACFPVFALLLGYTSGEIGYFDRESNTVGAVCARLSGDTAEVQGATGLRI 703
T+G + + +QG VF +L E +F + N G + +R++ DT+ + + +
Sbjct: 312 TMGHVHSHLQGE---VFGAVLRQ---ETEFF--QQNQTGNIMSRVTEDTSTLSDSLSENL 363
Query: 704 GLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESA 763
L L + + + LT+V+ LPL+ G Q + RE++ +
Sbjct: 364 SLFLWYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKS 423
Query: 764 TAIATEAVVSIKTVQSLGIESLFITRFQDALIDACAAVVKKS------RWRGLVLGLCIY 817
+ +A EA+ ++ TV+S E +F++ L + K++ W + G+ +
Sbjct: 424 SQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLK 483
Query: 818 VPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXXXXMYGAYMLGQSLVYAPSFNSAKTCGAR 877
V +L G LV G M + L P A +
Sbjct: 484 VGIL------YIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEK 537
Query: 878 ILSIINREPRIRTVDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTV 937
I ++R PR L G DV F+YP R ++L+G+ + G+
Sbjct: 538 IFEYLDRTPRCPPSGLLTPLH---LEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVT 594
Query: 938 ALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDR 997
ALVG +G GKSTV L+Q Y PT G + LDG + + L +Q+ V QEP +F R
Sbjct: 595 ALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQ-YEHRYLHRQVAAVGQEPQVFGR 653
Query: 998 TLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVC 1057
+L ENIAYG ++KPTM+E H+FI LP+GY+T +Q V
Sbjct: 654 SLQENIAYG-LTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVA 712
Query: 1058 IARALIRSPRLLLLDEATSALDANSERAVTEALDHAAK--GRTCITIAHRLTTIKDADII 1115
+ARALIR P +L+LD+ATSALDANS+ V + L + + R+ + I L+ ++ AD I
Sbjct: 713 LARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHI 772
Query: 1116 CVLDKGKIVEKGNHAELIGLKGHYWQL 1142
L+ G I E G H +L+ KG YW +
Sbjct: 773 LFLEGGAIREGGTHQQLMEKKGCYWAM 799
>AL671681-12|CAI17714.1| 808|Homo sapiens transporter 1,
ATP-binding cassette, sub-family Be, 9 (large
multifunctional pe protein.
Length = 808
Score = 248 bits (607), Expect = 9e-65
Identities = 149/493 (30%), Positives = 260/493 (52%), Gaps = 15/493 (3%)
Query: 51 AVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAVVSNLVGTSIICLCTAFPLGWK 110
AVLRQ+ +F + N+ S+++E+ L + + E L++ + + L
Sbjct: 327 AVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGSVS 386
Query: 111 LALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAFGGENIE 170
L + + +P + + + ++ ES +++ + A E L ++ TV +F E E
Sbjct: 387 LTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGE 446
Query: 171 VQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMY-GTRLIIEDANKPDDER 229
Q+++ L+ + + + + N + ++ L +G +Y G +L+ A +
Sbjct: 447 AQKFREKLQEIKTLNQKEAVAYAV-NSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLV 505
Query: 230 TYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKIDCLSEAGSS 289
T+++ + F+ A + + P ++ A G++ IF LD+ P+ C +
Sbjct: 506 TFVL---YQMQFT--QAVEVLLSIYPRVQ---KAVGSSEKIFEYLDRTPR--CPPSGLLT 555
Query: 290 PRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLY 349
P + G + +DV F+YP+R D+ +L+G + ++PGE ALVG +G GKST+ LLQ LY
Sbjct: 556 PLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLY 615
Query: 350 DPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPE-ATSEDVYRV 408
P G + LDG+ L +L + VGQEP +F ++ +NIA G + T E++
Sbjct: 616 QPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAA 675
Query: 409 AEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDP 468
A + AH FI LP GY+T + E G+ LSGGQ+Q +A+AR+L+R+P VL+LD+ATSALD
Sbjct: 676 AVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDA 735
Query: 469 HSEKQVQAALDRA--SVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGF 526
+S+ QV+ L + R+ L ++ LS + I+ ++ G I E GTH +LM+ KG
Sbjct: 736 NSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGC 795
Query: 527 YHKLVTSGKETKE 539
Y +V + + E
Sbjct: 796 YWAMVQAPADAPE 808
Score = 198 bits (483), Expect = 9e-50
Identities = 150/507 (29%), Positives = 235/507 (46%), Gaps = 27/507 (5%)
Query: 644 TVGSIAAFIQGACFPVFALLLGYTSGEIGYFDRESNTVGAVCARLSGDTAEVQGATGLRI 703
T+G + + +QG VF +L E +F + N G + +R++ DT+ + + +
Sbjct: 312 TMGHVHSHLQGE---VFGAVLRQ---ETEFF--QQNQTGNIMSRVTEDTSTLSDSLSENL 363
Query: 704 GLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESA 763
L L + + + LT+V+ LPL+ G Q + RE++ +
Sbjct: 364 SLFLWYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKS 423
Query: 764 TAIATEAVVSIKTVQSLGIESLFITRFQDALIDACAAVVKKS------RWRGLVLGLCIY 817
+ +A EA+ ++ TV+S E +F++ L + K++ W + G+ +
Sbjct: 424 SQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLK 483
Query: 818 VPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXXXXMYGAYMLGQSLVYAPSFNSAKTCGAR 877
V +L G LV G M + L P A +
Sbjct: 484 VGIL------YIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEK 537
Query: 878 ILSIINREPRIRTVDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTV 937
I ++R PR L G DV F+YP R ++L+G+ + G+
Sbjct: 538 IFEYLDRTPRCPPSGLLTPLH---LEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVT 594
Query: 938 ALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDR 997
ALVG +G GKSTV L+Q Y PT G + LDG + + L +Q+ V QEP +F R
Sbjct: 595 ALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQ-YEHRYLHRQVAAVGQEPQVFGR 653
Query: 998 TLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVC 1057
+L ENIAYG ++KPTM+E H+FI LP+GY+T +Q V
Sbjct: 654 SLQENIAYG-LTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVA 712
Query: 1058 IARALIRSPRLLLLDEATSALDANSERAVTEALDHAAK--GRTCITIAHRLTTIKDADII 1115
+ARALIR P +L+LD+ATSALDANS+ V + L + + R+ + I L+ ++ AD I
Sbjct: 713 LARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHI 772
Query: 1116 CVLDKGKIVEKGNHAELIGLKGHYWQL 1142
L+ G I E G H +L+ KG YW +
Sbjct: 773 LFLEGGAIREGGTHQQLMEKKGCYWAM 799
>AL669918-8|CAI18140.1| 808|Homo sapiens transporter 1, ATP-binding
cassette, sub-family Bpha protein.
Length = 808
Score = 248 bits (607), Expect = 9e-65
Identities = 149/493 (30%), Positives = 260/493 (52%), Gaps = 15/493 (3%)
Query: 51 AVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAVVSNLVGTSIICLCTAFPLGWK 110
AVLRQ+ +F + N+ S+++E+ L + + E L++ + + L
Sbjct: 327 AVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGSVS 386
Query: 111 LALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAFGGENIE 170
L + + +P + + + ++ ES +++ + A E L ++ TV +F E E
Sbjct: 387 LTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGE 446
Query: 171 VQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMY-GTRLIIEDANKPDDER 229
Q+++ L+ + + + + N + ++ L +G +Y G +L+ A +
Sbjct: 447 AQKFREKLQEIKTLNQKEAVAYAV-NSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLV 505
Query: 230 TYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKIDCLSEAGSS 289
T+++ + F+ A + + P ++ A G++ IF LD+ P+ C +
Sbjct: 506 TFVL---YQMQFT--QAVEVLLSIYPRVQ---KAVGSSEKIFEYLDRTPR--CPPSGLLT 555
Query: 290 PRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLY 349
P + G + +DV F+YP+R D+ +L+G + ++PGE ALVG +G GKST+ LLQ LY
Sbjct: 556 PLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLY 615
Query: 350 DPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPE-ATSEDVYRV 408
P G + LDG+ L +L + VGQEP +F ++ +NIA G + T E++
Sbjct: 616 QPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAA 675
Query: 409 AEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDP 468
A + AH FI LP GY+T + E G+ LSGGQ+Q +A+AR+L+R+P VL+LD+ATSALD
Sbjct: 676 AVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDA 735
Query: 469 HSEKQVQAALDRA--SVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGF 526
+S+ QV+ L + R+ L ++ LS + I+ ++ G I E GTH +LM+ KG
Sbjct: 736 NSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGC 795
Query: 527 YHKLVTSGKETKE 539
Y +V + + E
Sbjct: 796 YWAMVQAPADAPE 808
Score = 198 bits (483), Expect = 9e-50
Identities = 150/507 (29%), Positives = 235/507 (46%), Gaps = 27/507 (5%)
Query: 644 TVGSIAAFIQGACFPVFALLLGYTSGEIGYFDRESNTVGAVCARLSGDTAEVQGATGLRI 703
T+G + + +QG VF +L E +F + N G + +R++ DT+ + + +
Sbjct: 312 TMGHVHSHLQGE---VFGAVLRQ---ETEFF--QQNQTGNIMSRVTEDTSTLSDSLSENL 363
Query: 704 GLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESA 763
L L + + + LT+V+ LPL+ G Q + RE++ +
Sbjct: 364 SLFLWYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKS 423
Query: 764 TAIATEAVVSIKTVQSLGIESLFITRFQDALIDACAAVVKKS------RWRGLVLGLCIY 817
+ +A EA+ ++ TV+S E +F++ L + K++ W + G+ +
Sbjct: 424 SQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLK 483
Query: 818 VPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXXXXMYGAYMLGQSLVYAPSFNSAKTCGAR 877
V +L G LV G M + L P A +
Sbjct: 484 VGIL------YIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEK 537
Query: 878 ILSIINREPRIRTVDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTV 937
I ++R PR L G DV F+YP R ++L+G+ + G+
Sbjct: 538 IFEYLDRTPRCPPSGLLTPLH---LEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVT 594
Query: 938 ALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDR 997
ALVG +G GKSTV L+Q Y PT G + LDG + + L +Q+ V QEP +F R
Sbjct: 595 ALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQ-YEHRYLHRQVAAVGQEPQVFGR 653
Query: 998 TLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVC 1057
+L ENIAYG ++KPTM+E H+FI LP+GY+T +Q V
Sbjct: 654 SLQENIAYG-LTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVA 712
Query: 1058 IARALIRSPRLLLLDEATSALDANSERAVTEALDHAAK--GRTCITIAHRLTTIKDADII 1115
+ARALIR P +L+LD+ATSALDANS+ V + L + + R+ + I L+ ++ AD I
Sbjct: 713 LARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHI 772
Query: 1116 CVLDKGKIVEKGNHAELIGLKGHYWQL 1142
L+ G I E G H +L+ KG YW +
Sbjct: 773 LFLEGGAIREGGTHQQLMEKKGCYWAM 799
>AK074738-1|BAC11171.1| 472|Homo sapiens protein ( Homo sapiens
cDNA FLJ90257 fis, clone NT2RM4000444, weakly similar to
ANTIGEN PEPTIDE TRANSPORTER 1. ).
Length = 472
Score = 243 bits (595), Expect = 3e-63
Identities = 146/430 (33%), Positives = 225/430 (52%), Gaps = 16/430 (3%)
Query: 105 FPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAF 164
F L W+L+L P +M S Y + S + ++A AEE + ++KTV +F
Sbjct: 28 FSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSF 87
Query: 165 GGENIEVQRYKSLLEPAEISGSRRG---LFTGLGNGFNWVLTYSLNTIGFMYGTRLIIED 221
E E + Y L+ + ++ G+G +L ++ + YG L+I
Sbjct: 88 ANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLT-LLVVQVSIL--YYGGHLVISG 144
Query: 222 ANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKID 281
+ +II F + +S+ + GAA +F +D+ P +
Sbjct: 145 QMTSGNLIAFII-----YEFVLGDCMESVGSVYSGL---MQGVGAAEKVFEFIDRQPTM- 195
Query: 282 CLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
+ + +P + G + E+V F+Y +R ++L+ S + PG+ ALVG SG GKS+
Sbjct: 196 -VHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSC 254
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEAT 401
+ +L+ Y G V LDG+ + + +L + +V QEPVLF +I DNI+ G P
Sbjct: 255 VNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVP 314
Query: 402 SEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 461
E V A+ A AH FI L +GY T GE+GA LSGGQKQR+A+AR+L+R P VL+LDE
Sbjct: 315 FEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDE 374
Query: 462 ATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELM 521
ATSALD SE +Q A+ T L ++HRLST+ + H I+ +D+G +++QGTH +L+
Sbjct: 375 ATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLL 434
Query: 522 KAKGFYHKLV 531
G Y KLV
Sbjct: 435 AQGGLYAKLV 444
Score = 191 bits (465), Expect = 1e-47
Identities = 135/453 (29%), Positives = 219/453 (48%), Gaps = 24/453 (5%)
Query: 703 IGLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGSIWLEGIMSQKSQQDEREAMES 762
I + L+ VT + S +W+L+LV+ P+++ + G ++ ++ + A+
Sbjct: 10 INVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALAR 69
Query: 763 ATAIATEAVVSIKTVQSLGIES----LFITRFQDA--LIDACAAVVKKSRWRGLVLGLCI 816
A+ A E + ++KTV+S E +++ + Q L AA W GL +
Sbjct: 70 ASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGS---GLTL 126
Query: 817 YVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXXXX-MYGAYMLGQSLVYAPSFNSAKTCG 875
L+ S + YG LV G + G M VY+
Sbjct: 127 ---LVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAA- 182
Query: 876 ARILSIINREPRIRTVDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGK 935
++ I+R+P + L G +V F+Y TR H +L+ + + GK
Sbjct: 183 EKVFEFIDRQPTMVHDGSLAPDH---LEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGK 239
Query: 936 TVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILF 995
ALVG SG GKS+ + +++ FY G + LDG I+ + L + + +V QEP+LF
Sbjct: 240 VTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPIS-AYDHKYLHRVISLVSQEPVLF 298
Query: 996 DRTLAENIAYGDNSRKPTM--DEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXK 1053
R++ +NI+YG PT+ + H FI+ L GY T K
Sbjct: 299 ARSITDNISYG----LPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQK 354
Query: 1054 QRVCIARALIRSPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDAD 1113
QRV +ARAL+R+P +L+LDEATSALDA SE + +A+ + T + IAHRL+T++ A
Sbjct: 355 QRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAH 414
Query: 1114 IICVLDKGKIVEKGNHAELIGLKGHYWQLSKQQ 1146
+I VLDKG++V++G H +L+ G Y +L ++Q
Sbjct: 415 LIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQ 447
>X87344-8|CAA60788.1| 686|Homo sapiens TAP2 protein.
Length = 686
Score = 240 bits (587), Expect = 2e-62
Identities = 156/470 (33%), Positives = 249/470 (52%), Gaps = 16/470 (3%)
Query: 44 IRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAVVSNLVGTSIICLCT 103
IR+ +++LRQD+ +F L S++S + + + V+ + +
Sbjct: 225 IREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGF 284
Query: 104 AFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREME-SYSQAGKQAEEVLKSVKTVV 162
+ +L L + MPF+I A + N + + +RE++ + ++AG+ E + ++TV
Sbjct: 285 MLSISPRLTLLSLLHMPFTIAAE-KVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVR 343
Query: 163 AFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDA 222
+FG E EV RYK LE RR L L VL + + G +
Sbjct: 344 SFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQ------ 397
Query: 223 NKPDDERTYIIGIVLS-ITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKID 281
D E T G +LS + + + + TL + ++ + GAA +FS +D+ P +
Sbjct: 398 QMQDGELTQ--GSLLSFMIYQESVGSYVQTLVYIYGDMLSNV-GAAEKVFSYMDRQPNLP 454
Query: 282 CLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
S +P + G + +DV F+YP+R D +LKG + ++PGE ALVG +G GKST+
Sbjct: 455 --SPGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV 512
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEAT 401
LLQ LY P G V LD + + +L S + VGQEPVLF G++ +NIA G
Sbjct: 513 AALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE 572
Query: 402 SEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 461
+ V A+ A+A +FI+ + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDE
Sbjct: 573 DDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDE 632
Query: 462 ATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTI 511
ATSALD E+ +Q R RT L ++HRL T+ H+I+ + +G +
Sbjct: 633 ATSALDVQCEQALQDWNSRGD--RTVLVIAHRLQTVQRAHQILVLQEGKL 680
Score = 180 bits (438), Expect = 3e-44
Identities = 138/457 (30%), Positives = 223/457 (48%), Gaps = 16/457 (3%)
Query: 670 EIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTL 729
++G+F +E+ T G + +RLS DT + L ++L+ V + +S + +LTL
Sbjct: 237 DLGFF-QETKT-GELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTL 294
Query: 730 VSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFITR 789
+S +P + + + Q+ ++ ++A+ A + EAV ++TV+S G E + R
Sbjct: 295 LSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCR 354
Query: 790 FQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXX 849
+++AL ++ R L L + + L + G + G
Sbjct: 355 YKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMI 414
Query: 850 XX-MYGAYMLGQSLVYAPSFNSAKTCGA-RILSIINREPRIRTVDGLNDKQDWSASGNFS 907
G+Y+ Q+LVY + A ++ S ++R+P + + L + G
Sbjct: 415 YQESVGSYV--QTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPT---TLQGVVK 469
Query: 908 INDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIEL 967
DV F+YP R + +LKG+ + G+ ALVG +G GKSTV L+Q Y PT G + L
Sbjct: 470 FQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLL 529
Query: 968 DGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXH 1027
D I++ L Q+ V QEP+LF ++ NIAYG S + D+
Sbjct: 530 DEKPISQ-YEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCED--DKVMAAAQAAHAD 586
Query: 1028 NFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVT 1087
+FI + G T+ KQR+ IARAL+R PR+L+LDEATSALD E+A+
Sbjct: 587 DFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQ 646
Query: 1088 EALDHAAKG-RTCITIAHRLTTIKDADIICVLDKGKI 1123
D ++G RT + IAHRL T++ A I VL +GK+
Sbjct: 647 ---DWNSRGDRTVLVIAHRLQTVQRAHQILVLQEGKL 680
>X66401-4|CAA47027.1| 686|Homo sapiens TAP2 protein.
Length = 686
Score = 240 bits (587), Expect = 2e-62
Identities = 156/470 (33%), Positives = 249/470 (52%), Gaps = 16/470 (3%)
Query: 44 IRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAVVSNLVGTSIICLCT 103
IR+ +++LRQD+ +F L S++S + + + V+ + +
Sbjct: 225 IREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGF 284
Query: 104 AFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREME-SYSQAGKQAEEVLKSVKTVV 162
+ +L L + MPF+I A + N + + +RE++ + ++AG+ E + ++TV
Sbjct: 285 MLSISPRLTLLSLLHMPFTIAAE-KVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVR 343
Query: 163 AFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDA 222
+FG E EV RYK LE RR L L VL + + G +
Sbjct: 344 SFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQ------ 397
Query: 223 NKPDDERTYIIGIVLS-ITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKID 281
D E T G +LS + + + + TL + ++ + GAA +FS +D+ P +
Sbjct: 398 QMQDGELTQ--GSLLSFMIYQESVGSYVQTLVYIYGDMLSNV-GAAEKVFSYMDRQPNLP 454
Query: 282 CLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
S +P + G + +DV F+YP+R D +LKG + ++PGE ALVG +G GKST+
Sbjct: 455 --SPGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV 512
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEAT 401
LLQ LY P G V LD + + +L S + VGQEPVLF G++ +NIA G
Sbjct: 513 AALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE 572
Query: 402 SEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 461
+ V A+ A+A +FI+ + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDE
Sbjct: 573 DDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDE 632
Query: 462 ATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTI 511
ATSALD E+ +Q R RT L ++HRL T+ H+I+ + +G +
Sbjct: 633 ATSALDVQCEQALQDWNSRGD--RTVLVIAHRLQTVQRAHQILVLQEGKL 680
Score = 180 bits (438), Expect = 3e-44
Identities = 138/457 (30%), Positives = 223/457 (48%), Gaps = 16/457 (3%)
Query: 670 EIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTL 729
++G+F +E+ T G + +RLS DT + L ++L+ V + +S + +LTL
Sbjct: 237 DLGFF-QETKT-GELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTL 294
Query: 730 VSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFITR 789
+S +P + + + Q+ ++ ++A+ A + EAV ++TV+S G E + R
Sbjct: 295 LSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCR 354
Query: 790 FQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXX 849
+++AL ++ R L L + + L + G + G
Sbjct: 355 YKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMI 414
Query: 850 XX-MYGAYMLGQSLVYAPSFNSAKTCGA-RILSIINREPRIRTVDGLNDKQDWSASGNFS 907
G+Y+ Q+LVY + A ++ S ++R+P + + L + G
Sbjct: 415 YQESVGSYV--QTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPT---TLQGVVK 469
Query: 908 INDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIEL 967
DV F+YP R + +LKG+ + G+ ALVG +G GKSTV L+Q Y PT G + L
Sbjct: 470 FQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLL 529
Query: 968 DGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXH 1027
D I++ L Q+ V QEP+LF ++ NIAYG S + D+
Sbjct: 530 DEKPISQ-YEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCED--DKVMAAAQAAHAD 586
Query: 1028 NFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVT 1087
+FI + G T+ KQR+ IARAL+R PR+L+LDEATSALD E+A+
Sbjct: 587 DFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQ 646
Query: 1088 EALDHAAKG-RTCITIAHRLTTIKDADIICVLDKGKI 1123
D ++G RT + IAHRL T++ A I VL +GK+
Sbjct: 647 ---DWNSRGDRTVLVIAHRLQTVQRAHQILVLQEGKL 680
>U07844-1|AAA79901.1| 622|Homo sapiens ABC transport protein
protein.
Length = 622
Score = 240 bits (587), Expect = 2e-62
Identities = 159/471 (33%), Positives = 250/471 (53%), Gaps = 18/471 (3%)
Query: 44 IRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAVVSNLVGTSIICLCT 103
IR+ +++LRQD+ +F L S++S + + + V+ + +
Sbjct: 161 IREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGF 220
Query: 104 AFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREME-SYSQAGKQAEEVLKSVKTVV 162
+ +L L + MPF+I A + N + + +RE++ + ++AG+ E + ++TV
Sbjct: 221 MLSISPRLTLLSLLHMPFTIAAE-KVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVR 279
Query: 163 AFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDA 222
+FG E EV RYK LE RR L L VL + + G +
Sbjct: 280 SFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQ------ 333
Query: 223 NKPDDERTYIIGIVLS-ITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKID 281
D E T G +LS + + + + TL + ++ + GAA +FS +D+ P +
Sbjct: 334 QMQDGELTQ--GSLLSFMIYQESVGSYVQTLVYIYGDMLSNV-GAAEKVFSYMDRQPNLP 390
Query: 282 CLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
S +P + G + +DV F+YP+R D +LKG + ++PGE ALVG +G GKST+
Sbjct: 391 --SPGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV 448
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEAT 401
LLQ LY P G V LD + + +L S + VGQEPVLF G++ +NIA G
Sbjct: 449 AALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE 508
Query: 402 SEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 461
+ V A+ A+A +FI+ + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDE
Sbjct: 509 DDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDE 568
Query: 462 ATSALDPHSEKQVQAALDRASVG-RTTLTVSHRLSTIVNCHRIICMDQGTI 511
ATSALD E QA D S G RT L ++HRL T+ H+I+ + +G +
Sbjct: 569 ATSALDVQCE---QALQDWNSCGDRTVLVIAHRLQTVQRAHQILVLQEGKL 616
Score = 180 bits (438), Expect = 3e-44
Identities = 136/456 (29%), Positives = 222/456 (48%), Gaps = 14/456 (3%)
Query: 670 EIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTL 729
++G+F +E+ T G + +RLS DT + L ++L+ V + +S + +LTL
Sbjct: 173 DLGFF-QETKT-GELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTL 230
Query: 730 VSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFITR 789
+S +P + + + Q+ ++ ++A+ A + EAV ++TV+S G E + R
Sbjct: 231 LSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCR 290
Query: 790 FQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXX 849
+++AL ++ R L L + + L + G + G
Sbjct: 291 YKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMI 350
Query: 850 XX-MYGAYMLGQSLVYAPSFNSAKTCGA-RILSIINREPRIRTVDGLNDKQDWSASGNFS 907
G+Y+ Q+LVY + A ++ S ++R+P + + L + G
Sbjct: 351 YQESVGSYV--QTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPT---TLQGVVK 405
Query: 908 INDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIEL 967
DV F+YP R + +LKG+ + G+ ALVG +G GKSTV L+Q Y PT G + L
Sbjct: 406 FQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLL 465
Query: 968 DGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXH 1027
D I++ L Q+ V QEP+LF ++ NIAYG S + D+
Sbjct: 466 DEKPISQ-YEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCED--DKVMAAAQAAHAD 522
Query: 1028 NFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVT 1087
+FI + G T+ KQR+ IARAL+R PR+L+LDEATSALD E+A+
Sbjct: 523 DFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQ 582
Query: 1088 EALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKI 1123
+ ++ RT + IAHRL T++ A I VL +GK+
Sbjct: 583 DW--NSCGDRTVLVIAHRLQTVQRAHQILVLQEGKL 616
>M74447-1|AAA59841.1| 703|Homo sapiens PSF-2 protein.
Length = 703
Score = 240 bits (587), Expect = 2e-62
Identities = 159/490 (32%), Positives = 258/490 (52%), Gaps = 19/490 (3%)
Query: 44 IRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAVVSNLVGTSIICLCT 103
IR+ +++LRQD+ +F L S++S + + + V+ + +
Sbjct: 225 IREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGF 284
Query: 104 AFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREME-SYSQAGKQAEEVLKSVKTVV 162
+ +L L + MPF+I A + N + + +RE++ + ++AG+ E + ++TV
Sbjct: 285 MLSISPRLTLLSLLHMPFTIAAE-KVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVR 343
Query: 163 AFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDA 222
+FG E EV RYK LE RR L L VL + + G + +
Sbjct: 344 SFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLIRRVLHLGVQMLMLSCGLQQM---- 399
Query: 223 NKPDDERTYIIGIVLS-ITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKID 281
D E T G +LS + + + + TL + ++ + GAA +FS +D+ P +
Sbjct: 400 --QDGELTQ--GSLLSFMIYQESVGSYVQTLVYIYGDMLSNV-GAAEKVFSYMDRQPNLP 454
Query: 282 CLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
S +P + G + +DV F+YP+R D +LKG + ++PGE ALVG +G GKST+
Sbjct: 455 --SPGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV 512
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEAT 401
LLQ LY P G V LD + + +L S + VGQEPVLF G++ +NIA G
Sbjct: 513 AALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE 572
Query: 402 SEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 461
+ V A+ A+A +FI+ + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDE
Sbjct: 573 DDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDE 632
Query: 462 ATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELM 521
ATSALD E+ +Q R RT L ++HRL + H+I+ + +G + + +L
Sbjct: 633 ATSALDVQCEQALQDWNSRGD--RTVLVIAHRLQAVQRAHQILVLQEGKLQKL---AQLQ 687
Query: 522 KAKGFYHKLV 531
+ + Y +LV
Sbjct: 688 EGQDLYSRLV 697
Score = 178 bits (434), Expect = 8e-44
Identities = 137/457 (29%), Positives = 222/457 (48%), Gaps = 16/457 (3%)
Query: 670 EIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTL 729
++G+F +E+ T G + +RLS DT + L ++L+ V + +S + +LTL
Sbjct: 237 DLGFF-QETKT-GELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTL 294
Query: 730 VSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFITR 789
+S +P + + + Q+ ++ ++A+ A + EAV ++TV+S G E + R
Sbjct: 295 LSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCR 354
Query: 790 FQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXX 849
+++AL ++ R L L + + L + G + G
Sbjct: 355 YKEALEQCRQLYWRRDLERALYLLIRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMI 414
Query: 850 XX-MYGAYMLGQSLVYAPSFNSAKTCGA-RILSIINREPRIRTVDGLNDKQDWSASGNFS 907
G+Y+ Q+LVY + A ++ S ++R+P + + L + G
Sbjct: 415 YQESVGSYV--QTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPT---TLQGVVK 469
Query: 908 INDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIEL 967
DV F+YP R + +LKG+ + G+ ALVG +G GKSTV L+Q Y PT G + L
Sbjct: 470 FQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLL 529
Query: 968 DGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXH 1027
D I++ L Q+ V QEP+LF ++ NIAYG S + D+
Sbjct: 530 DEKPISQ-YEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCED--DKVMAAAQAAHAD 586
Query: 1028 NFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVT 1087
+FI + G T+ KQR+ IARAL+R PR+L+LDEATSALD E+A+
Sbjct: 587 DFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQ 646
Query: 1088 EALDHAAKG-RTCITIAHRLTTIKDADIICVLDKGKI 1123
D ++G RT + IAHRL ++ A I VL +GK+
Sbjct: 647 ---DWNSRGDRTVLVIAHRLQAVQRAHQILVLQEGKL 680
>BT009906-1|AAP88908.1| 686|Homo sapiens transporter 2, ATP-binding
cassette, sub-family B (MDR/TAP) protein.
Length = 686
Score = 240 bits (587), Expect = 2e-62
Identities = 156/470 (33%), Positives = 249/470 (52%), Gaps = 16/470 (3%)
Query: 44 IRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAVVSNLVGTSIICLCT 103
IR+ +++LRQD+ +F L S++S + + + V+ + +
Sbjct: 225 IREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGF 284
Query: 104 AFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREME-SYSQAGKQAEEVLKSVKTVV 162
+ +L L + MPF+I A + N + + +RE++ + ++AG+ E + ++TV
Sbjct: 285 MLSISPRLTLLSLLHMPFTIAAE-KVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVR 343
Query: 163 AFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDA 222
+FG E EV RYK LE RR L L VL + + G +
Sbjct: 344 SFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQ------ 397
Query: 223 NKPDDERTYIIGIVLS-ITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKID 281
D E T G +LS + + + + TL + ++ + GAA +FS +D+ P +
Sbjct: 398 QMQDGELTQ--GSLLSFMIYQESVGSYVQTLVYIYGDMLSNV-GAAEKVFSYMDRQPNLP 454
Query: 282 CLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
S +P + G + +DV F+YP+R D +LKG + ++PGE ALVG +G GKST+
Sbjct: 455 --SPGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV 512
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEAT 401
LLQ LY P G V LD + + +L S + VGQEPVLF G++ +NIA G
Sbjct: 513 AALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE 572
Query: 402 SEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 461
+ V A+ A+A +FI+ + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDE
Sbjct: 573 DDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDE 632
Query: 462 ATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTI 511
ATSALD E+ +Q R RT L ++HRL T+ H+I+ + +G +
Sbjct: 633 ATSALDVQCEQALQDWNSRGD--RTVLVIAHRLQTVQRAHQILVLQEGKL 680
Score = 180 bits (438), Expect = 3e-44
Identities = 138/457 (30%), Positives = 223/457 (48%), Gaps = 16/457 (3%)
Query: 670 EIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTL 729
++G+F +E+ T G + +RLS DT + L ++L+ V + +S + +LTL
Sbjct: 237 DLGFF-QETKT-GELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTL 294
Query: 730 VSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFITR 789
+S +P + + + Q+ ++ ++A+ A + EAV ++TV+S G E + R
Sbjct: 295 LSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCR 354
Query: 790 FQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXX 849
+++AL ++ R L L + + L + G + G
Sbjct: 355 YKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMI 414
Query: 850 XX-MYGAYMLGQSLVYAPSFNSAKTCGA-RILSIINREPRIRTVDGLNDKQDWSASGNFS 907
G+Y+ Q+LVY + A ++ S ++R+P + + L + G
Sbjct: 415 YQESVGSYV--QTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPT---TLQGVVK 469
Query: 908 INDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIEL 967
DV F+YP R + +LKG+ + G+ ALVG +G GKSTV L+Q Y PT G + L
Sbjct: 470 FQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLL 529
Query: 968 DGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXH 1027
D I++ L Q+ V QEP+LF ++ NIAYG S + D+
Sbjct: 530 DEKPISQ-YEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCED--DKVMAAAQAAHAD 586
Query: 1028 NFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVT 1087
+FI + G T+ KQR+ IARAL+R PR+L+LDEATSALD E+A+
Sbjct: 587 DFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQ 646
Query: 1088 EALDHAAKG-RTCITIAHRLTTIKDADIICVLDKGKI 1123
D ++G RT + IAHRL T++ A I VL +GK+
Sbjct: 647 ---DWNSRGDRTVLVIAHRLQTVQRAHQILVLQEGKL 680
>AL935043-2|CAI18622.1| 686|Homo sapiens transporter 2, ATP-binding
cassette, sub-family Bta protein.
Length = 686
Score = 240 bits (587), Expect = 2e-62
Identities = 156/470 (33%), Positives = 249/470 (52%), Gaps = 16/470 (3%)
Query: 44 IRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAVVSNLVGTSIICLCT 103
IR+ +++LRQD+ +F L S++S + + + V+ + +
Sbjct: 225 IREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGF 284
Query: 104 AFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREME-SYSQAGKQAEEVLKSVKTVV 162
+ +L L + MPF+I A + N + + +RE++ + ++AG+ E + ++TV
Sbjct: 285 MLSISPRLTLLSLLHMPFTIAAE-KVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVR 343
Query: 163 AFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDA 222
+FG E EV RYK LE RR L L VL + + G +
Sbjct: 344 SFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQ------ 397
Query: 223 NKPDDERTYIIGIVLS-ITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKID 281
D E T G +LS + + + + TL + ++ + GAA +FS +D+ P +
Sbjct: 398 QMQDGELTQ--GSLLSFMIYQESVGSYVQTLVYIYGDMLSNV-GAAEKVFSYMDRQPNLP 454
Query: 282 CLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
S +P + G + +DV F+YP+R D +LKG + ++PGE ALVG +G GKST+
Sbjct: 455 --SPGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV 512
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEAT 401
LLQ LY P G V LD + + +L S + VGQEPVLF G++ +NIA G
Sbjct: 513 AALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE 572
Query: 402 SEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 461
+ V A+ A+A +FI+ + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDE
Sbjct: 573 DDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDE 632
Query: 462 ATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTI 511
ATSALD E+ +Q R RT L ++HRL T+ H+I+ + +G +
Sbjct: 633 ATSALDVQCEQALQDWNSRGD--RTVLVIAHRLQTVQRAHQILVLQEGKL 680
Score = 180 bits (438), Expect = 3e-44
Identities = 138/457 (30%), Positives = 223/457 (48%), Gaps = 16/457 (3%)
Query: 670 EIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTL 729
++G+F +E+ T G + +RLS DT + L ++L+ V + +S + +LTL
Sbjct: 237 DLGFF-QETKT-GELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTL 294
Query: 730 VSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFITR 789
+S +P + + + Q+ ++ ++A+ A + EAV ++TV+S G E + R
Sbjct: 295 LSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCR 354
Query: 790 FQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXX 849
+++AL ++ R L L + + L + G + G
Sbjct: 355 YKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMI 414
Query: 850 XX-MYGAYMLGQSLVYAPSFNSAKTCGA-RILSIINREPRIRTVDGLNDKQDWSASGNFS 907
G+Y+ Q+LVY + A ++ S ++R+P + + L + G
Sbjct: 415 YQESVGSYV--QTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPT---TLQGVVK 469
Query: 908 INDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIEL 967
DV F+YP R + +LKG+ + G+ ALVG +G GKSTV L+Q Y PT G + L
Sbjct: 470 FQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLL 529
Query: 968 DGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXH 1027
D I++ L Q+ V QEP+LF ++ NIAYG S + D+
Sbjct: 530 DEKPISQ-YEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCED--DKVMAAAQAAHAD 586
Query: 1028 NFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVT 1087
+FI + G T+ KQR+ IARAL+R PR+L+LDEATSALD E+A+
Sbjct: 587 DFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQ 646
Query: 1088 EALDHAAKG-RTCITIAHRLTTIKDADIICVLDKGKI 1123
D ++G RT + IAHRL T++ A I VL +GK+
Sbjct: 647 ---DWNSRGDRTVLVIAHRLQTVQRAHQILVLQEGKL 680
>AL671681-8|CAI17711.1| 686|Homo sapiens transporter 2, ATP-binding
cassette, sub-family Bta 9 (pseudogene) protein.
Length = 686
Score = 240 bits (587), Expect = 2e-62
Identities = 156/470 (33%), Positives = 249/470 (52%), Gaps = 16/470 (3%)
Query: 44 IRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAVVSNLVGTSIICLCT 103
IR+ +++LRQD+ +F L S++S + + + V+ + +
Sbjct: 225 IREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGF 284
Query: 104 AFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREME-SYSQAGKQAEEVLKSVKTVV 162
+ +L L + MPF+I A + N + + +RE++ + ++AG+ E + ++TV
Sbjct: 285 MLSISPRLTLLSLLHMPFTIAAE-KVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVR 343
Query: 163 AFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDA 222
+FG E EV RYK LE RR L L VL + + G +
Sbjct: 344 SFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQ------ 397
Query: 223 NKPDDERTYIIGIVLS-ITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKID 281
D E T G +LS + + + + TL + ++ + GAA +FS +D+ P +
Sbjct: 398 QMQDGELTQ--GSLLSFMIYQESVGSYVQTLVYIYGDMLSNV-GAAEKVFSYMDRQPNLP 454
Query: 282 CLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
S +P + G + +DV F+YP+R D +LKG + ++PGE ALVG +G GKST+
Sbjct: 455 --SPGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV 512
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEAT 401
LLQ LY P G V LD + + +L S + VGQEPVLF G++ +NIA G
Sbjct: 513 AALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE 572
Query: 402 SEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 461
+ V A+ A+A +FI+ + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDE
Sbjct: 573 DDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDE 632
Query: 462 ATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTI 511
ATSALD E+ +Q R RT L ++HRL T+ H+I+ + +G +
Sbjct: 633 ATSALDVQCEQALQDWNSRGD--RTVLVIAHRLQTVQRAHQILVLQEGKL 680
Score = 180 bits (438), Expect = 3e-44
Identities = 138/457 (30%), Positives = 223/457 (48%), Gaps = 16/457 (3%)
Query: 670 EIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTL 729
++G+F +E+ T G + +RLS DT + L ++L+ V + +S + +LTL
Sbjct: 237 DLGFF-QETKT-GELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTL 294
Query: 730 VSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFITR 789
+S +P + + + Q+ ++ ++A+ A + EAV ++TV+S G E + R
Sbjct: 295 LSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCR 354
Query: 790 FQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXX 849
+++AL ++ R L L + + L + G + G
Sbjct: 355 YKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMI 414
Query: 850 XX-MYGAYMLGQSLVYAPSFNSAKTCGA-RILSIINREPRIRTVDGLNDKQDWSASGNFS 907
G+Y+ Q+LVY + A ++ S ++R+P + + L + G
Sbjct: 415 YQESVGSYV--QTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPT---TLQGVVK 469
Query: 908 INDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIEL 967
DV F+YP R + +LKG+ + G+ ALVG +G GKSTV L+Q Y PT G + L
Sbjct: 470 FQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLL 529
Query: 968 DGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXH 1027
D I++ L Q+ V QEP+LF ++ NIAYG S + D+
Sbjct: 530 DEKPISQ-YEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCED--DKVMAAAQAAHAD 586
Query: 1028 NFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVT 1087
+FI + G T+ KQR+ IARAL+R PR+L+LDEATSALD E+A+
Sbjct: 587 DFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQ 646
Query: 1088 EALDHAAKG-RTCITIAHRLTTIKDADIICVLDKGKI 1123
D ++G RT + IAHRL T++ A I VL +GK+
Sbjct: 647 ---DWNSRGDRTVLVIAHRLQTVQRAHQILVLQEGKL 680
>AL669918-4|CAI18137.1| 686|Homo sapiens transporter 2, ATP-binding
cassette, sub-family Bunit 11 protein.
Length = 686
Score = 240 bits (587), Expect = 2e-62
Identities = 156/470 (33%), Positives = 249/470 (52%), Gaps = 16/470 (3%)
Query: 44 IRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAVVSNLVGTSIICLCT 103
IR+ +++LRQD+ +F L S++S + + + V+ + +
Sbjct: 225 IREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGF 284
Query: 104 AFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREME-SYSQAGKQAEEVLKSVKTVV 162
+ +L L + MPF+I A + N + + +RE++ + ++AG+ E + ++TV
Sbjct: 285 MLSISPRLTLLSLLHMPFTIAAE-KVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVR 343
Query: 163 AFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDA 222
+FG E EV RYK LE RR L L VL + + G +
Sbjct: 344 SFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQ------ 397
Query: 223 NKPDDERTYIIGIVLS-ITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKID 281
D E T G +LS + + + + TL + ++ + GAA +FS +D+ P +
Sbjct: 398 QMQDGELTQ--GSLLSFMIYQESVGSYVQTLVYIYGDMLSNV-GAAEKVFSYMDRQPNLP 454
Query: 282 CLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
S +P + G + +DV F+YP+R D +LKG + ++PGE ALVG +G GKST+
Sbjct: 455 --SPGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV 512
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEAT 401
LLQ LY P G V LD + + +L S + VGQEPVLF G++ +NIA G
Sbjct: 513 AALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE 572
Query: 402 SEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 461
+ V A+ A+A +FI+ + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDE
Sbjct: 573 DDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDE 632
Query: 462 ATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTI 511
ATSALD E+ +Q R RT L ++HRL T+ H+I+ + +G +
Sbjct: 633 ATSALDVQCEQALQDWNSRGD--RTVLVIAHRLQTVQRAHQILVLQEGKL 680
Score = 180 bits (438), Expect = 3e-44
Identities = 138/457 (30%), Positives = 223/457 (48%), Gaps = 16/457 (3%)
Query: 670 EIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTL 729
++G+F +E+ T G + +RLS DT + L ++L+ V + +S + +LTL
Sbjct: 237 DLGFF-QETKT-GELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTL 294
Query: 730 VSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFITR 789
+S +P + + + Q+ ++ ++A+ A + EAV ++TV+S G E + R
Sbjct: 295 LSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCR 354
Query: 790 FQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXX 849
+++AL ++ R L L + + L + G + G
Sbjct: 355 YKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMI 414
Query: 850 XX-MYGAYMLGQSLVYAPSFNSAKTCGA-RILSIINREPRIRTVDGLNDKQDWSASGNFS 907
G+Y+ Q+LVY + A ++ S ++R+P + + L + G
Sbjct: 415 YQESVGSYV--QTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPT---TLQGVVK 469
Query: 908 INDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIEL 967
DV F+YP R + +LKG+ + G+ ALVG +G GKSTV L+Q Y PT G + L
Sbjct: 470 FQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLL 529
Query: 968 DGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXH 1027
D I++ L Q+ V QEP+LF ++ NIAYG S + D+
Sbjct: 530 DEKPISQ-YEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCED--DKVMAAAQAAHAD 586
Query: 1028 NFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVT 1087
+FI + G T+ KQR+ IARAL+R PR+L+LDEATSALD E+A+
Sbjct: 587 DFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQ 646
Query: 1088 EALDHAAKG-RTCITIAHRLTTIKDADIICVLDKGKI 1123
D ++G RT + IAHRL T++ A I VL +GK+
Sbjct: 647 ---DWNSRGDRTVLVIAHRLQTVQRAHQILVLQEGKL 680
>Z22935-1|CAA80522.1| 703|Homo sapiens TAP2B protein.
Length = 703
Score = 239 bits (586), Expect = 3e-62
Identities = 159/490 (32%), Positives = 257/490 (52%), Gaps = 19/490 (3%)
Query: 44 IRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAVVSNLVGTSIICLCT 103
IR+ +++LRQD+ +F L S++S + + + V+ + +
Sbjct: 225 IREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGF 284
Query: 104 AFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREME-SYSQAGKQAEEVLKSVKTVV 162
+ +L L + MPF+I A + N + + +RE++ + ++AG+ E + ++TV
Sbjct: 285 MLSISPRLTLLSLLHMPFTIAAE-KVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVR 343
Query: 163 AFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDA 222
+FG E EV RYK LE RR L L VL + + G +
Sbjct: 344 SFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQ------ 397
Query: 223 NKPDDERTYIIGIVLS-ITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKID 281
D E T G +LS + + + + TL + ++ + GAA +FS +D+ P +
Sbjct: 398 QMQDGELTQ--GSLLSFMIYQESVGSYVQTLVYIYGDMLSNV-GAAEKVFSYMDRQPNLP 454
Query: 282 CLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
S +P + G + +DV F+YP+R D +LKG + ++PGE ALVG +G GKST+
Sbjct: 455 --SPGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV 512
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEAT 401
LLQ LY P G V LD + + +L S + VGQEPVLF G++ +NIA G
Sbjct: 513 AALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE 572
Query: 402 SEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 461
+ V A+ A+A +FI+ + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDE
Sbjct: 573 DDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDE 632
Query: 462 ATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELM 521
ATSALD E+ +Q R RT L ++HRL + H+I+ + +G + + +L
Sbjct: 633 ATSALDVQCEQALQDWNSRGD--RTVLVIAHRLQAVQRAHQILVLQEGKLQKL---AQLQ 687
Query: 522 KAKGFYHKLV 531
+ + Y +LV
Sbjct: 688 EGQDLYSRLV 697
Score = 178 bits (433), Expect = 1e-43
Identities = 137/457 (29%), Positives = 222/457 (48%), Gaps = 16/457 (3%)
Query: 670 EIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTL 729
++G+F +E+ T G + +RLS DT + L ++L+ V + +S + +LTL
Sbjct: 237 DLGFF-QETKT-GELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTL 294
Query: 730 VSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFITR 789
+S +P + + + Q+ ++ ++A+ A + EAV ++TV+S G E + R
Sbjct: 295 LSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCR 354
Query: 790 FQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXX 849
+++AL ++ R L L + + L + G + G
Sbjct: 355 YKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMI 414
Query: 850 XX-MYGAYMLGQSLVYAPSFNSAKTCGA-RILSIINREPRIRTVDGLNDKQDWSASGNFS 907
G+Y+ Q+LVY + A ++ S ++R+P + + L + G
Sbjct: 415 YQESVGSYV--QTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPT---TLQGVVK 469
Query: 908 INDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIEL 967
DV F+YP R + +LKG+ + G+ ALVG +G GKSTV L+Q Y PT G + L
Sbjct: 470 FQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLL 529
Query: 968 DGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXH 1027
D I++ L Q+ V QEP+LF ++ NIAYG S + D+
Sbjct: 530 DEKPISQ-YEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCED--DKVMAAAQAAHAD 586
Query: 1028 NFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVT 1087
+FI + G T+ KQR+ IARAL+R PR+L+LDEATSALD E+A+
Sbjct: 587 DFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQ 646
Query: 1088 EALDHAAKG-RTCITIAHRLTTIKDADIICVLDKGKI 1123
D ++G RT + IAHRL ++ A I VL +GK+
Sbjct: 647 ---DWNSRGDRTVLVIAHRLQAVQRAHQILVLQEGKL 680
>BX682530-4|CAI41935.1| 703|Homo sapiens transporter 2 ATP-binding
cassette sub-family B (MDR/TAP) protein.
Length = 703
Score = 239 bits (586), Expect = 3e-62
Identities = 159/490 (32%), Positives = 257/490 (52%), Gaps = 19/490 (3%)
Query: 44 IRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAVVSNLVGTSIICLCT 103
IR+ +++LRQD+ +F L S++S + + + V+ + +
Sbjct: 225 IREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGF 284
Query: 104 AFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREME-SYSQAGKQAEEVLKSVKTVV 162
+ +L L + MPF+I A + N + + +RE++ + ++AG+ E + ++TV
Sbjct: 285 MLSISPRLTLLSLLHMPFTIAAE-KVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVR 343
Query: 163 AFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDA 222
+FG E EV RYK LE RR L L VL + + G +
Sbjct: 344 SFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQ------ 397
Query: 223 NKPDDERTYIIGIVLS-ITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKID 281
D E T G +LS + + + + TL + ++ + GAA +FS +D+ P +
Sbjct: 398 QMQDGELTQ--GSLLSFMIYQESVGSYVQTLVYIYGDMLSNV-GAAEKVFSYMDRQPNLP 454
Query: 282 CLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
S +P + G + +DV F+YP+R D +LKG + ++PGE ALVG +G GKST+
Sbjct: 455 --SPGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV 512
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEAT 401
LLQ LY P G V LD + + +L S + VGQEPVLF G++ +NIA G
Sbjct: 513 AALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE 572
Query: 402 SEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 461
+ V A+ A+A +FI+ + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDE
Sbjct: 573 DDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDE 632
Query: 462 ATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELM 521
ATSALD E+ +Q R RT L ++HRL + H+I+ + +G + + +L
Sbjct: 633 ATSALDVQCEQALQDWNSRGD--RTVLVIAHRLQAVQRAHQILVLQEGKLQKL---AQLQ 687
Query: 522 KAKGFYHKLV 531
+ + Y +LV
Sbjct: 688 EGQDLYSRLV 697
Score = 178 bits (433), Expect = 1e-43
Identities = 137/457 (29%), Positives = 222/457 (48%), Gaps = 16/457 (3%)
Query: 670 EIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTL 729
++G+F +E+ T G + +RLS DT + L ++L+ V + +S + +LTL
Sbjct: 237 DLGFF-QETKT-GELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTL 294
Query: 730 VSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFITR 789
+S +P + + + Q+ ++ ++A+ A + EAV ++TV+S G E + R
Sbjct: 295 LSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCR 354
Query: 790 FQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXX 849
+++AL ++ R L L + + L + G + G
Sbjct: 355 YKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMI 414
Query: 850 XX-MYGAYMLGQSLVYAPSFNSAKTCGA-RILSIINREPRIRTVDGLNDKQDWSASGNFS 907
G+Y+ Q+LVY + A ++ S ++R+P + + L + G
Sbjct: 415 YQESVGSYV--QTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPT---TLQGVVK 469
Query: 908 INDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIEL 967
DV F+YP R + +LKG+ + G+ ALVG +G GKSTV L+Q Y PT G + L
Sbjct: 470 FQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLL 529
Query: 968 DGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXH 1027
D I++ L Q+ V QEP+LF ++ NIAYG S + D+
Sbjct: 530 DEKPISQ-YEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCED--DKVMAAAQAAHAD 586
Query: 1028 NFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVT 1087
+FI + G T+ KQR+ IARAL+R PR+L+LDEATSALD E+A+
Sbjct: 587 DFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQ 646
Query: 1088 EALDHAAKG-RTCITIAHRLTTIKDADIICVLDKGKI 1123
D ++G RT + IAHRL ++ A I VL +GK+
Sbjct: 647 ---DWNSRGDRTVLVIAHRLQAVQRAHQILVLQEGKL 680
>AK222823-1|BAD96543.1| 703|Homo sapiens transporter 2, ATP-binding
cassette, sub-family B isoform 1 variant protein.
Length = 703
Score = 239 bits (586), Expect = 3e-62
Identities = 159/490 (32%), Positives = 257/490 (52%), Gaps = 19/490 (3%)
Query: 44 IRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAVVSNLVGTSIICLCT 103
IR+ +++LRQD+ +F L S++S + + + V+ + +
Sbjct: 225 IREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGF 284
Query: 104 AFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREME-SYSQAGKQAEEVLKSVKTVV 162
+ +L L + MPF+I A + N + + +RE++ + ++AG+ E + ++TV
Sbjct: 285 MLSISPRLTLLSLLHMPFTIAAE-KVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVR 343
Query: 163 AFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDA 222
+FG E EV RYK LE RR L L VL + + G +
Sbjct: 344 SFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQ------ 397
Query: 223 NKPDDERTYIIGIVLS-ITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKID 281
D E T G +LS + + + + TL + ++ + GAA +FS +D+ P +
Sbjct: 398 QMQDGELTQ--GSLLSFMIYQESVGSYVQTLVYIYGDMLSNV-GAAEKVFSYMDRQPNLP 454
Query: 282 CLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
S +P + G + +DV F+YP+R D +LKG + ++PGE ALVG +G GKST+
Sbjct: 455 --SPGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV 512
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEAT 401
LLQ LY P G V LD + + +L S + VGQEPVLF G++ +NIA G
Sbjct: 513 AALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE 572
Query: 402 SEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 461
+ V A+ A+A +FI+ + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDE
Sbjct: 573 DDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDE 632
Query: 462 ATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELM 521
ATSALD E+ +Q R RT L ++HRL + H+I+ + +G + + +L
Sbjct: 633 ATSALDVQCEQALQDWNSRGD--RTVLVIAHRLQAVQRAHQILVLQEGKLQKL---AQLQ 687
Query: 522 KAKGFYHKLV 531
+ + Y +LV
Sbjct: 688 EGQDLYSRLV 697
Score = 178 bits (433), Expect = 1e-43
Identities = 137/457 (29%), Positives = 222/457 (48%), Gaps = 16/457 (3%)
Query: 670 EIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTL 729
++G+F +E+ T G + +RLS DT + L ++L+ V + +S + +LTL
Sbjct: 237 DLGFF-QETKT-GELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTL 294
Query: 730 VSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFITR 789
+S +P + + + Q+ ++ ++A+ A + EAV ++TV+S G E + R
Sbjct: 295 LSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCR 354
Query: 790 FQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXX 849
+++AL ++ R L L + + L + G + G
Sbjct: 355 YKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMI 414
Query: 850 XX-MYGAYMLGQSLVYAPSFNSAKTCGA-RILSIINREPRIRTVDGLNDKQDWSASGNFS 907
G+Y+ Q+LVY + A ++ S ++R+P + + L + G
Sbjct: 415 YQESVGSYV--QTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPT---TLQGVVK 469
Query: 908 INDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIEL 967
DV F+YP R + +LKG+ + G+ ALVG +G GKSTV L+Q Y PT G + L
Sbjct: 470 FQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLL 529
Query: 968 DGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXH 1027
D I++ L Q+ V QEP+LF ++ NIAYG S + D+
Sbjct: 530 DEKPISQ-YEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCED--DKVMAAAQAAHAD 586
Query: 1028 NFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVT 1087
+FI + G T+ KQR+ IARAL+R PR+L+LDEATSALD E+A+
Sbjct: 587 DFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQ 646
Query: 1088 EALDHAAKG-RTCITIAHRLTTIKDADIICVLDKGKI 1123
D ++G RT + IAHRL ++ A I VL +GK+
Sbjct: 647 ---DWNSRGDRTVLVIAHRLQAVQRAHQILVLQEGKL 680
>AB208953-1|BAD92190.1| 704|Homo sapiens transporter 2, ATP-binding
cassette, sub-family B isoform 1 variant protein.
Length = 704
Score = 239 bits (586), Expect = 3e-62
Identities = 159/490 (32%), Positives = 257/490 (52%), Gaps = 19/490 (3%)
Query: 44 IRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAVVSNLVGTSIICLCT 103
IR+ +++LRQD+ +F L S++S + + + V+ + +
Sbjct: 226 IREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGF 285
Query: 104 AFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREME-SYSQAGKQAEEVLKSVKTVV 162
+ +L L + MPF+I A + N + + +RE++ + ++AG+ E + ++TV
Sbjct: 286 MLSISPRLTLLSLLHMPFTIAAE-KVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVR 344
Query: 163 AFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDA 222
+FG E EV RYK LE RR L L VL + + G +
Sbjct: 345 SFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQ------ 398
Query: 223 NKPDDERTYIIGIVLS-ITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKID 281
D E T G +LS + + + + TL + ++ + GAA +FS +D+ P +
Sbjct: 399 QMQDGELTQ--GSLLSFMIYQESVGSYVQTLVYIYGDMLSNV-GAAEKVFSYMDRQPNLP 455
Query: 282 CLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
S +P + G + +DV F+YP+R D +LKG + ++PGE ALVG +G GKST+
Sbjct: 456 --SPGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV 513
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEAT 401
LLQ LY P G V LD + + +L S + VGQEPVLF G++ +NIA G
Sbjct: 514 AALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE 573
Query: 402 SEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 461
+ V A+ A+A +FI+ + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDE
Sbjct: 574 DDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDE 633
Query: 462 ATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELM 521
ATSALD E+ +Q R RT L ++HRL + H+I+ + +G + + +L
Sbjct: 634 ATSALDVQCEQALQDWNSRGD--RTVLVIAHRLQAVQRAHQILVLQEGKLQKL---AQLQ 688
Query: 522 KAKGFYHKLV 531
+ + Y +LV
Sbjct: 689 EGQDLYSRLV 698
Score = 178 bits (433), Expect = 1e-43
Identities = 137/457 (29%), Positives = 222/457 (48%), Gaps = 16/457 (3%)
Query: 670 EIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTL 729
++G+F +E+ T G + +RLS DT + L ++L+ V + +S + +LTL
Sbjct: 238 DLGFF-QETKT-GELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTL 295
Query: 730 VSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFITR 789
+S +P + + + Q+ ++ ++A+ A + EAV ++TV+S G E + R
Sbjct: 296 LSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCR 355
Query: 790 FQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXX 849
+++AL ++ R L L + + L + G + G
Sbjct: 356 YKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMI 415
Query: 850 XX-MYGAYMLGQSLVYAPSFNSAKTCGA-RILSIINREPRIRTVDGLNDKQDWSASGNFS 907
G+Y+ Q+LVY + A ++ S ++R+P + + L + G
Sbjct: 416 YQESVGSYV--QTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPT---TLQGVVK 470
Query: 908 INDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIEL 967
DV F+YP R + +LKG+ + G+ ALVG +G GKSTV L+Q Y PT G + L
Sbjct: 471 FQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLL 530
Query: 968 DGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXH 1027
D I++ L Q+ V QEP+LF ++ NIAYG S + D+
Sbjct: 531 DEKPISQ-YEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCED--DKVMAAAQAAHAD 587
Query: 1028 NFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVT 1087
+FI + G T+ KQR+ IARAL+R PR+L+LDEATSALD E+A+
Sbjct: 588 DFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQ 647
Query: 1088 EALDHAAKG-RTCITIAHRLTTIKDADIICVLDKGKI 1123
D ++G RT + IAHRL ++ A I VL +GK+
Sbjct: 648 ---DWNSRGDRTVLVIAHRLQAVQRAHQILVLQEGKL 681
>AB073779-1|BAB71769.1| 703|Homo sapiens ABC-transporter protein.
Length = 703
Score = 239 bits (586), Expect = 3e-62
Identities = 159/490 (32%), Positives = 257/490 (52%), Gaps = 19/490 (3%)
Query: 44 IRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAVVSNLVGTSIICLCT 103
IR+ +++LRQD+ +F L S++S + + + V+ + +
Sbjct: 225 IREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGF 284
Query: 104 AFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREME-SYSQAGKQAEEVLKSVKTVV 162
+ +L L + MPF+I A + N + + +RE++ + ++AG+ E + ++TV
Sbjct: 285 MLSISPRLTLLSLLHMPFTIAAE-KVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVR 343
Query: 163 AFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDA 222
+FG E EV RYK LE RR L L VL + + G +
Sbjct: 344 SFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQ------ 397
Query: 223 NKPDDERTYIIGIVLS-ITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKID 281
D E T G +LS + + + + TL + ++ + GAA +FS +D+ P +
Sbjct: 398 QMQDGELTQ--GSLLSFMIYQESVGSYVQTLVYIYGDMLSNV-GAAEKVFSYMDRQPNLP 454
Query: 282 CLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
S +P + G + +DV F+YP+R D +LKG + ++PGE ALVG +G GKST+
Sbjct: 455 --SPGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV 512
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEAT 401
LLQ LY P G V LD + + +L S + VGQEPVLF G++ +NIA G
Sbjct: 513 AALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE 572
Query: 402 SEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 461
+ V A+ A+A +FI+ + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDE
Sbjct: 573 DDKVVAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDE 632
Query: 462 ATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELM 521
ATSALD E+ +Q R RT L ++HRL + H+I+ + +G + + +L
Sbjct: 633 ATSALDVQCEQALQDWNSRGD--RTVLVIAHRLQAVQRAHQILVLQEGKLQKL---AQLQ 687
Query: 522 KAKGFYHKLV 531
+ + Y +LV
Sbjct: 688 EGQDLYSRLV 697
Score = 178 bits (433), Expect = 1e-43
Identities = 137/457 (29%), Positives = 222/457 (48%), Gaps = 16/457 (3%)
Query: 670 EIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTL 729
++G+F +E+ T G + +RLS DT + L ++L+ V + +S + +LTL
Sbjct: 237 DLGFF-QETKT-GELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTL 294
Query: 730 VSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFITR 789
+S +P + + + Q+ ++ ++A+ A + EAV ++TV+S G E + R
Sbjct: 295 LSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCR 354
Query: 790 FQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXX 849
+++AL ++ R L L + + L + G + G
Sbjct: 355 YKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMI 414
Query: 850 XX-MYGAYMLGQSLVYAPSFNSAKTCGA-RILSIINREPRIRTVDGLNDKQDWSASGNFS 907
G+Y+ Q+LVY + A ++ S ++R+P + + L + G
Sbjct: 415 YQESVGSYV--QTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPT---TLQGVVK 469
Query: 908 INDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIEL 967
DV F+YP R + +LKG+ + G+ ALVG +G GKSTV L+Q Y PT G + L
Sbjct: 470 FQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLL 529
Query: 968 DGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXH 1027
D I++ L Q+ V QEP+LF ++ NIAYG S + D+
Sbjct: 530 DEKPISQ-YEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCED--DKVVAAAQAAHAD 586
Query: 1028 NFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVT 1087
+FI + G T+ KQR+ IARAL+R PR+L+LDEATSALD E+A+
Sbjct: 587 DFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQ 646
Query: 1088 EALDHAAKG-RTCITIAHRLTTIKDADIICVLDKGKI 1123
D ++G RT + IAHRL ++ A I VL +GK+
Sbjct: 647 ---DWNSRGDRTVLVIAHRLQAVQRAHQILVLQEGKL 680
>AF100418-1|AAD23381.1| 483|Homo sapiens TAP2 protein protein.
Length = 483
Score = 239 bits (584), Expect = 5e-62
Identities = 156/470 (33%), Positives = 250/470 (53%), Gaps = 16/470 (3%)
Query: 44 IRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAVVSNLVGTSIICLCT 103
IR+ +++LRQD+ +F L S++S + + + V+ + +
Sbjct: 22 IREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGF 81
Query: 104 AFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREME-SYSQAGKQAEEVLKSVKTVV 162
+ +L L + MPF+I A + N + + +RE++ + ++AG+ E + ++TV
Sbjct: 82 MLSISPRLTLLSLLHMPFTIAAE-KVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVR 140
Query: 163 AFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDA 222
+FG E EV RYK LE RR L L VL + + G + +
Sbjct: 141 SFGAEEHEVCRYKEALEQCRQLYWRRDLERTLYLLVRRVLHLGVQMLMLSCGLQQM---- 196
Query: 223 NKPDDERTYIIGIVLS-ITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKID 281
D E T G +LS + + + + TL + ++ + GAA +FS +D+ P +
Sbjct: 197 --QDGELTQ--GSLLSFMIYQESVGSYVQTLVYIYGDMLSNV-GAAEKVFSYMDRQPNLP 251
Query: 282 CLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
S +P + G + +DV F+YP+R D +LKG + ++PGE ALVG +G GKST+
Sbjct: 252 --SPGTLAPTTLQGIVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV 309
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEAT 401
LLQ LY P G V LD + + +L S + VGQEPVLF G++ +NIA G
Sbjct: 310 AALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE 369
Query: 402 SEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 461
+ V A+ A+A +FI+ + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDE
Sbjct: 370 DDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDE 429
Query: 462 ATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTI 511
ATSALD E+ +Q R RT L ++HRL T+ H+I+ + +G +
Sbjct: 430 ATSALDVQCEQALQDWNSRGD--RTVLVIAHRLQTVQRAHQILVLQEGKL 477
Score = 179 bits (436), Expect = 5e-44
Identities = 138/457 (30%), Positives = 223/457 (48%), Gaps = 16/457 (3%)
Query: 670 EIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTL 729
++G+F +E+ T G + +RLS DT + L ++L+ V + +S + +LTL
Sbjct: 34 DLGFF-QETKT-GELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTL 91
Query: 730 VSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFITR 789
+S +P + + + Q+ ++ ++A+ A + EAV ++TV+S G E + R
Sbjct: 92 LSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCR 151
Query: 790 FQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXX 849
+++AL ++ R L L + + L + G + G
Sbjct: 152 YKEALEQCRQLYWRRDLERTLYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMI 211
Query: 850 XX-MYGAYMLGQSLVYAPSFNSAKTCGA-RILSIINREPRIRTVDGLNDKQDWSASGNFS 907
G+Y+ Q+LVY + A ++ S ++R+P + + L + G
Sbjct: 212 YQESVGSYV--QTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPT---TLQGIVK 266
Query: 908 INDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIEL 967
DV F+YP R + +LKG+ + G+ ALVG +G GKSTV L+Q Y PT G + L
Sbjct: 267 FQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLL 326
Query: 968 DGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXH 1027
D I++ L Q+ V QEP+LF ++ NIAYG S + D+
Sbjct: 327 DEKPISQ-YEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCED--DKVMAAAQAAHAD 383
Query: 1028 NFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVT 1087
+FI + G T+ KQR+ IARAL+R PR+L+LDEATSALD E+A+
Sbjct: 384 DFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQ 443
Query: 1088 EALDHAAKG-RTCITIAHRLTTIKDADIICVLDKGKI 1123
D ++G RT + IAHRL T++ A I VL +GK+
Sbjct: 444 ---DWNSRGDRTVLVIAHRLQTVQRAHQILVLQEGKL 477
>Z22936-1|CAA80523.1| 686|Homo sapiens TAP2E protein.
Length = 686
Score = 238 bits (583), Expect = 7e-62
Identities = 155/470 (32%), Positives = 248/470 (52%), Gaps = 16/470 (3%)
Query: 44 IRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAVVSNLVGTSIICLCT 103
IR+ +++LRQD+ +F L S++S + + + V+ + +
Sbjct: 225 IREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGF 284
Query: 104 AFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREME-SYSQAGKQAEEVLKSVKTVV 162
+ +L L + MPF+I A + N + + +RE++ + ++AG+ E + ++TV
Sbjct: 285 MLSISPRLTLLSLLHMPFTIAAE-KVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVR 343
Query: 163 AFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDA 222
+FG E EV RYK LE RR L L VL + + G +
Sbjct: 344 SFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQ------ 397
Query: 223 NKPDDERTYIIGIVLS-ITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKID 281
D E T G +LS + + + + TL + ++ + GAA +FS +D+ P +
Sbjct: 398 QMQDGELTQ--GSLLSFMIYQESVGSYVQTLVYIYGDMLSNV-GAAEKVFSYMDRQPNLP 454
Query: 282 CLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
S +P + G + +DV F+YP+R D +LKG + ++PGE ALVG +G GKST+
Sbjct: 455 --SPGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV 512
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEAT 401
LLQ LY P G V LD + + +L S + VGQEPVLF G++ +NI G
Sbjct: 513 AALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNITYGLQSCE 572
Query: 402 SEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 461
+ V A+ A+A +FI+ + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDE
Sbjct: 573 DDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDE 632
Query: 462 ATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTI 511
ATSALD E+ +Q R RT L ++HRL T+ H+I+ + +G +
Sbjct: 633 ATSALDVQCEQALQDWNSRGD--RTVLVIAHRLQTVQRAHQILVLQEGKL 680
Score = 178 bits (434), Expect = 8e-44
Identities = 137/457 (29%), Positives = 222/457 (48%), Gaps = 16/457 (3%)
Query: 670 EIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTL 729
++G+F +E+ T G + +RLS DT + L ++L+ V + +S + +LTL
Sbjct: 237 DLGFF-QETKT-GELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTL 294
Query: 730 VSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFITR 789
+S +P + + + Q+ ++ ++A+ A + EAV ++TV+S G E + R
Sbjct: 295 LSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCR 354
Query: 790 FQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXX 849
+++AL ++ R L L + + L + G + G
Sbjct: 355 YKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMI 414
Query: 850 XX-MYGAYMLGQSLVYAPSFNSAKTCGA-RILSIINREPRIRTVDGLNDKQDWSASGNFS 907
G+Y+ Q+LVY + A ++ S ++R+P + + L + G
Sbjct: 415 YQESVGSYV--QTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPT---TLQGVVK 469
Query: 908 INDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIEL 967
DV F+YP R + +LKG+ + G+ ALVG +G GKSTV L+Q Y PT G + L
Sbjct: 470 FQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLL 529
Query: 968 DGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXH 1027
D I++ L Q+ V QEP+LF ++ NI YG S + D+
Sbjct: 530 DEKPISQ-YEHCYLHSQVVSVGQEPVLFSGSVRNNITYGLQSCED--DKVMAAAQAAHAD 586
Query: 1028 NFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVT 1087
+FI + G T+ KQR+ IARAL+R PR+L+LDEATSALD E+A+
Sbjct: 587 DFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQ 646
Query: 1088 EALDHAAKG-RTCITIAHRLTTIKDADIICVLDKGKI 1123
D ++G RT + IAHRL T++ A I VL +GK+
Sbjct: 647 ---DWNSRGDRTVLVIAHRLQTVQRAHQILVLQEGKL 680
>AF136750-1|AAD23601.1| 483|Homo sapiens TAP2 protein protein.
Length = 483
Score = 237 bits (579), Expect = 2e-61
Identities = 155/470 (32%), Positives = 249/470 (52%), Gaps = 16/470 (3%)
Query: 44 IRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAVVSNLVGTSIICLCT 103
IR+ +++LRQD+ +F L S++S + + + V+ + +
Sbjct: 22 IREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGF 81
Query: 104 AFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREME-SYSQAGKQAEEVLKSVKTVV 162
+ +L L + MPF+I A + N + + +RE++ + ++AG+ E + ++TV
Sbjct: 82 MLSISPRLTLLSLLHMPFTIAAE-KVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVR 140
Query: 163 AFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDA 222
+FG E EV RYK LE RR L L VL + + G + +
Sbjct: 141 SFGAEEHEVCRYKEALEQCRQLYWRRDLERTLYLLVRRVLHLGVQMLMLSCGLQQM---- 196
Query: 223 NKPDDERTYIIGIVLS-ITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKID 281
D E T G +LS + + + + TL + ++ + GAA +FS +D+ P +
Sbjct: 197 --QDGELTQ--GSLLSFMIYQESVGSYVQTLVYIYGDMLSNV-GAAEKVFSYMDRQPNLP 251
Query: 282 CLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
S +P + G + +DV F+YP+R D +LKG + ++PGE ALVG +G GKST+
Sbjct: 252 --SPGTLAPTTLQGIVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV 309
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEAT 401
LLQ LY P G V LD + + +L S + VGQEPVLF G++ +NIA G
Sbjct: 310 AALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE 369
Query: 402 SEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 461
+ V A+ A+A +FI+ + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDE
Sbjct: 370 DDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDE 429
Query: 462 ATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTI 511
ATSALD E+ +Q R RT L ++HRL + H+I+ + +G +
Sbjct: 430 ATSALDVQCEQALQDWNSRGD--RTVLVIAHRLQAVQRAHQILVLQEGKL 477
Score = 177 bits (431), Expect = 2e-43
Identities = 137/457 (29%), Positives = 222/457 (48%), Gaps = 16/457 (3%)
Query: 670 EIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTL 729
++G+F +E+ T G + +RLS DT + L ++L+ V + +S + +LTL
Sbjct: 34 DLGFF-QETKT-GELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTL 91
Query: 730 VSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFITR 789
+S +P + + + Q+ ++ ++A+ A + EAV ++TV+S G E + R
Sbjct: 92 LSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCR 151
Query: 790 FQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXX 849
+++AL ++ R L L + + L + G + G
Sbjct: 152 YKEALEQCRQLYWRRDLERTLYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMI 211
Query: 850 XX-MYGAYMLGQSLVYAPSFNSAKTCGA-RILSIINREPRIRTVDGLNDKQDWSASGNFS 907
G+Y+ Q+LVY + A ++ S ++R+P + + L + G
Sbjct: 212 YQESVGSYV--QTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPT---TLQGIVK 266
Query: 908 INDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIEL 967
DV F+YP R + +LKG+ + G+ ALVG +G GKSTV L+Q Y PT G + L
Sbjct: 267 FQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLL 326
Query: 968 DGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXH 1027
D I++ L Q+ V QEP+LF ++ NIAYG S + D+
Sbjct: 327 DEKPISQ-YEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCED--DKVMAAAQAAHAD 383
Query: 1028 NFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVT 1087
+FI + G T+ KQR+ IARAL+R PR+L+LDEATSALD E+A+
Sbjct: 384 DFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQ 443
Query: 1088 EALDHAAKG-RTCITIAHRLTTIKDADIICVLDKGKI 1123
D ++G RT + IAHRL ++ A I VL +GK+
Sbjct: 444 ---DWNSRGDRTVLVIAHRLQAVQRAHQILVLQEGKL 477
>BT009918-1|AAP88920.1| 753|Homo sapiens ATP-binding cassette,
sub-family B (MDR/TAP), member 7 protein.
Length = 753
Score = 233 bits (570), Expect = 3e-60
Identities = 140/420 (33%), Positives = 235/420 (55%), Gaps = 15/420 (3%)
Query: 105 FPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAF 164
+ G + AL + + +VA+T ++T+ I ++ + AG A + L + +TV F
Sbjct: 288 YKCGAQFALVTLGTLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYF 347
Query: 165 GGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDANK 224
E E QRY L+ E + + + L + + I F G I+ A++
Sbjct: 348 NNERYEAQRYDGFLKTYETASLKSTSTLAM-------LNFGQSAI-FSVGLTAIMVLASQ 399
Query: 225 PDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKIDCLS 284
T +G ++ + ++ + + A ++F+LL +I
Sbjct: 400 GIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIK--D 457
Query: 285 EAGSSPRRVIGE---ISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
+ +SP ++ + ++ ++VHF Y K+L G S + G+ VA+VG SG GKSTI
Sbjct: 458 KVMASPLQITPQTATVAFDNVHFEYIEGQ--KVLSGISFEVPAGKKVAIVGGSGSGKSTI 515
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEAT 401
++LL R Y+P +GS+ L G+N++ +++ LR ++GVV Q+ VLF TIY N+ G A+
Sbjct: 516 VRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISAS 575
Query: 402 SEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 461
E+VY VA++A H+ I +P+GY+T +GERG LSGG+KQR+AIAR++L++P V+L DE
Sbjct: 576 PEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDE 635
Query: 462 ATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELM 521
ATS+LD +E+ + A+ RT++ ++HRLST+V+ II +DQG + E+GTH L+
Sbjct: 636 ATSSLDSITEETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLL 695
Score = 178 bits (434), Expect = 8e-44
Identities = 95/227 (41%), Positives = 138/227 (60%), Gaps = 5/227 (2%)
Query: 907 SINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIE 966
+ ++V F Y Q +L GI V AGK VA+VG SG GKST+++L+ RFY+P G+I
Sbjct: 474 AFDNVHFEYIEG--QKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIY 531
Query: 967 LDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXX 1026
L G +I + ++L LR+ +GVV Q+ +LF T+ N+ YG+ S P +E
Sbjct: 532 LAGQNI-QDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASP--EEVYAVAKLAGL 588
Query: 1027 HNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAV 1086
H+ I+ +P GY+T KQRV IARA+++ P ++L DEATS+LD+ +E +
Sbjct: 589 HDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETI 648
Query: 1087 TEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELI 1133
A+ K RT I IAHRL+T+ DAD I VLD+GK+ E+G H L+
Sbjct: 649 LGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLL 695
>BC006323-1|AAH06323.1| 753|Homo sapiens ATP-binding cassette,
sub-family B (MDR/TAP), member 7 protein.
Length = 753
Score = 233 bits (570), Expect = 3e-60
Identities = 140/420 (33%), Positives = 235/420 (55%), Gaps = 15/420 (3%)
Query: 105 FPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAF 164
+ G + AL + + +VA+T ++T+ I ++ + AG A + L + +TV F
Sbjct: 288 YKCGAQFALVTLGTLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYF 347
Query: 165 GGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDANK 224
E E QRY L+ E + + + L + + I F G I+ A++
Sbjct: 348 NNERYEAQRYDGFLKTYETASLKSTSTLAM-------LNFGQSAI-FSVGLTAIMVLASQ 399
Query: 225 PDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKIDCLS 284
T +G ++ + ++ + + A ++F+LL +I
Sbjct: 400 GIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIK--D 457
Query: 285 EAGSSPRRVIGE---ISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
+ +SP ++ + ++ ++VHF Y K+L G S + G+ VA+VG SG GKSTI
Sbjct: 458 KVMASPLQITPQTATVAFDNVHFEYIEGQ--KVLSGISFEVPAGKKVAIVGGSGSGKSTI 515
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEAT 401
++LL R Y+P +GS+ L G+N++ +++ LR ++GVV Q+ VLF TIY N+ G A+
Sbjct: 516 VRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISAS 575
Query: 402 SEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 461
E+VY VA++A H+ I +P+GY+T +GERG LSGG+KQR+AIAR++L++P V+L DE
Sbjct: 576 PEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDE 635
Query: 462 ATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELM 521
ATS+LD +E+ + A+ RT++ ++HRLST+V+ II +DQG + E+GTH L+
Sbjct: 636 ATSSLDSITEETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLL 695
Score = 178 bits (434), Expect = 8e-44
Identities = 95/227 (41%), Positives = 138/227 (60%), Gaps = 5/227 (2%)
Query: 907 SINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIE 966
+ ++V F Y Q +L GI V AGK VA+VG SG GKST+++L+ RFY+P G+I
Sbjct: 474 AFDNVHFEYIEG--QKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIY 531
Query: 967 LDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXX 1026
L G +I + ++L LR+ +GVV Q+ +LF T+ N+ YG+ S P +E
Sbjct: 532 LAGQNI-QDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASP--EEVYAVAKLAGL 588
Query: 1027 HNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAV 1086
H+ I+ +P GY+T KQRV IARA+++ P ++L DEATS+LD+ +E +
Sbjct: 589 HDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETI 648
Query: 1087 TEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELI 1133
A+ K RT I IAHRL+T+ DAD I VLD+GK+ E+G H L+
Sbjct: 649 LGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLL 695
>AL360179-2|CAH70565.1| 752|Homo sapiens ATP-binding cassette,
sub-family B (MDR/TAP), member 7 protein.
Length = 752
Score = 233 bits (570), Expect = 3e-60
Identities = 140/420 (33%), Positives = 235/420 (55%), Gaps = 15/420 (3%)
Query: 105 FPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAF 164
+ G + AL + + +VA+T ++T+ I ++ + AG A + L + +TV F
Sbjct: 287 YKCGAQFALVTLGTLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYF 346
Query: 165 GGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDANK 224
E E QRY L+ E + + + L + + I F G I+ A++
Sbjct: 347 NNERYEAQRYDGFLKTYETASLKSTSTLAM-------LNFGQSAI-FSVGLTAIMVLASQ 398
Query: 225 PDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKIDCLS 284
T +G ++ + ++ + + A ++F+LL +I
Sbjct: 399 GIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIK--D 456
Query: 285 EAGSSPRRVIGE---ISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
+ +SP ++ + ++ ++VHF Y K+L G S + G+ VA+VG SG GKSTI
Sbjct: 457 KVMASPLQITPQTATVAFDNVHFEYIEGQ--KVLSGISFEVPAGKKVAIVGGSGSGKSTI 514
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEAT 401
++LL R Y+P +GS+ L G+N++ +++ LR ++GVV Q+ VLF TIY N+ G A+
Sbjct: 515 VRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISAS 574
Query: 402 SEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 461
E+VY VA++A H+ I +P+GY+T +GERG LSGG+KQR+AIAR++L++P V+L DE
Sbjct: 575 PEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDE 634
Query: 462 ATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELM 521
ATS+LD +E+ + A+ RT++ ++HRLST+V+ II +DQG + E+GTH L+
Sbjct: 635 ATSSLDSITEETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLL 694
Score = 178 bits (434), Expect = 8e-44
Identities = 95/227 (41%), Positives = 138/227 (60%), Gaps = 5/227 (2%)
Query: 907 SINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIE 966
+ ++V F Y Q +L GI V AGK VA+VG SG GKST+++L+ RFY+P G+I
Sbjct: 473 AFDNVHFEYIEG--QKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIY 530
Query: 967 LDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXX 1026
L G +I + ++L LR+ +GVV Q+ +LF T+ N+ YG+ S P +E
Sbjct: 531 LAGQNI-QDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASP--EEVYAVAKLAGL 587
Query: 1027 HNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAV 1086
H+ I+ +P GY+T KQRV IARA+++ P ++L DEATS+LD+ +E +
Sbjct: 588 HDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETI 647
Query: 1087 TEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELI 1133
A+ K RT I IAHRL+T+ DAD I VLD+GK+ E+G H L+
Sbjct: 648 LGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLL 694
>AL360179-1|CAH70564.1| 753|Homo sapiens ATP-binding cassette,
sub-family B (MDR/TAP), member 7 protein.
Length = 753
Score = 233 bits (570), Expect = 3e-60
Identities = 140/420 (33%), Positives = 235/420 (55%), Gaps = 15/420 (3%)
Query: 105 FPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAF 164
+ G + AL + + +VA+T ++T+ I ++ + AG A + L + +TV F
Sbjct: 288 YKCGAQFALVTLGTLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYF 347
Query: 165 GGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDANK 224
E E QRY L+ E + + + L + + I F G I+ A++
Sbjct: 348 NNERYEAQRYDGFLKTYETASLKSTSTLAM-------LNFGQSAI-FSVGLTAIMVLASQ 399
Query: 225 PDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKIDCLS 284
T +G ++ + ++ + + A ++F+LL +I
Sbjct: 400 GIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIK--D 457
Query: 285 EAGSSPRRVIGE---ISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
+ +SP ++ + ++ ++VHF Y K+L G S + G+ VA+VG SG GKSTI
Sbjct: 458 KVMASPLQITPQTATVAFDNVHFEYIEGQ--KVLSGISFEVPAGKKVAIVGGSGSGKSTI 515
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEAT 401
++LL R Y+P +GS+ L G+N++ +++ LR ++GVV Q+ VLF TIY N+ G A+
Sbjct: 516 VRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISAS 575
Query: 402 SEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 461
E+VY VA++A H+ I +P+GY+T +GERG LSGG+KQR+AIAR++L++P V+L DE
Sbjct: 576 PEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDE 635
Query: 462 ATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELM 521
ATS+LD +E+ + A+ RT++ ++HRLST+V+ II +DQG + E+GTH L+
Sbjct: 636 ATSSLDSITEETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLL 695
Score = 178 bits (434), Expect = 8e-44
Identities = 95/227 (41%), Positives = 138/227 (60%), Gaps = 5/227 (2%)
Query: 907 SINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIE 966
+ ++V F Y Q +L GI V AGK VA+VG SG GKST+++L+ RFY+P G+I
Sbjct: 474 AFDNVHFEYIEG--QKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIY 531
Query: 967 LDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXX 1026
L G +I + ++L LR+ +GVV Q+ +LF T+ N+ YG+ S P +E
Sbjct: 532 LAGQNI-QDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASP--EEVYAVAKLAGL 588
Query: 1027 HNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAV 1086
H+ I+ +P GY+T KQRV IARA+++ P ++L DEATS+LD+ +E +
Sbjct: 589 HDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETI 648
Query: 1087 TEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELI 1133
A+ K RT I IAHRL+T+ DAD I VLD+GK+ E+G H L+
Sbjct: 649 LGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLL 695
>AL359545-2|CAI41573.1| 752|Homo sapiens ATP-binding cassette,
sub-family B (MDR/TAP), member 7 protein.
Length = 752
Score = 233 bits (570), Expect = 3e-60
Identities = 140/420 (33%), Positives = 235/420 (55%), Gaps = 15/420 (3%)
Query: 105 FPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAF 164
+ G + AL + + +VA+T ++T+ I ++ + AG A + L + +TV F
Sbjct: 287 YKCGAQFALVTLGTLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYF 346
Query: 165 GGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDANK 224
E E QRY L+ E + + + L + + I F G I+ A++
Sbjct: 347 NNERYEAQRYDGFLKTYETASLKSTSTLAM-------LNFGQSAI-FSVGLTAIMVLASQ 398
Query: 225 PDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKIDCLS 284
T +G ++ + ++ + + A ++F+LL +I
Sbjct: 399 GIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIK--D 456
Query: 285 EAGSSPRRVIGE---ISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
+ +SP ++ + ++ ++VHF Y K+L G S + G+ VA+VG SG GKSTI
Sbjct: 457 KVMASPLQITPQTATVAFDNVHFEYIEGQ--KVLSGISFEVPAGKKVAIVGGSGSGKSTI 514
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEAT 401
++LL R Y+P +GS+ L G+N++ +++ LR ++GVV Q+ VLF TIY N+ G A+
Sbjct: 515 VRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISAS 574
Query: 402 SEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 461
E+VY VA++A H+ I +P+GY+T +GERG LSGG+KQR+AIAR++L++P V+L DE
Sbjct: 575 PEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDE 634
Query: 462 ATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELM 521
ATS+LD +E+ + A+ RT++ ++HRLST+V+ II +DQG + E+GTH L+
Sbjct: 635 ATSSLDSITEETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLL 694
Score = 178 bits (434), Expect = 8e-44
Identities = 95/227 (41%), Positives = 138/227 (60%), Gaps = 5/227 (2%)
Query: 907 SINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIE 966
+ ++V F Y Q +L GI V AGK VA+VG SG GKST+++L+ RFY+P G+I
Sbjct: 473 AFDNVHFEYIEG--QKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIY 530
Query: 967 LDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXX 1026
L G +I + ++L LR+ +GVV Q+ +LF T+ N+ YG+ S P +E
Sbjct: 531 LAGQNI-QDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASP--EEVYAVAKLAGL 587
Query: 1027 HNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAV 1086
H+ I+ +P GY+T KQRV IARA+++ P ++L DEATS+LD+ +E +
Sbjct: 588 HDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETI 647
Query: 1087 TEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELI 1133
A+ K RT I IAHRL+T+ DAD I VLD+GK+ E+G H L+
Sbjct: 648 LGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLL 694
>AL359545-1|CAI41574.1| 753|Homo sapiens ATP-binding cassette,
sub-family B (MDR/TAP), member 7 protein.
Length = 753
Score = 233 bits (570), Expect = 3e-60
Identities = 140/420 (33%), Positives = 235/420 (55%), Gaps = 15/420 (3%)
Query: 105 FPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAF 164
+ G + AL + + +VA+T ++T+ I ++ + AG A + L + +TV F
Sbjct: 288 YKCGAQFALVTLGTLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYF 347
Query: 165 GGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDANK 224
E E QRY L+ E + + + L + + I F G I+ A++
Sbjct: 348 NNERYEAQRYDGFLKTYETASLKSTSTLAM-------LNFGQSAI-FSVGLTAIMVLASQ 399
Query: 225 PDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKIDCLS 284
T +G ++ + ++ + + A ++F+LL +I
Sbjct: 400 GIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIK--D 457
Query: 285 EAGSSPRRVIGE---ISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
+ +SP ++ + ++ ++VHF Y K+L G S + G+ VA+VG SG GKSTI
Sbjct: 458 KVMASPLQITPQTATVAFDNVHFEYIEGQ--KVLSGISFEVPAGKKVAIVGGSGSGKSTI 515
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEAT 401
++LL R Y+P +GS+ L G+N++ +++ LR ++GVV Q+ VLF TIY N+ G A+
Sbjct: 516 VRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISAS 575
Query: 402 SEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 461
E+VY VA++A H+ I +P+GY+T +GERG LSGG+KQR+AIAR++L++P V+L DE
Sbjct: 576 PEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDE 635
Query: 462 ATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELM 521
ATS+LD +E+ + A+ RT++ ++HRLST+V+ II +DQG + E+GTH L+
Sbjct: 636 ATSSLDSITEETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLL 695
Score = 178 bits (434), Expect = 8e-44
Identities = 95/227 (41%), Positives = 138/227 (60%), Gaps = 5/227 (2%)
Query: 907 SINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIE 966
+ ++V F Y Q +L GI V AGK VA+VG SG GKST+++L+ RFY+P G+I
Sbjct: 474 AFDNVHFEYIEG--QKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIY 531
Query: 967 LDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXX 1026
L G +I + ++L LR+ +GVV Q+ +LF T+ N+ YG+ S P +E
Sbjct: 532 LAGQNI-QDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASP--EEVYAVAKLAGL 588
Query: 1027 HNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAV 1086
H+ I+ +P GY+T KQRV IARA+++ P ++L DEATS+LD+ +E +
Sbjct: 589 HDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETI 648
Query: 1087 TEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELI 1133
A+ K RT I IAHRL+T+ DAD I VLD+GK+ E+G H L+
Sbjct: 649 LGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLL 695
>AF241887-1|AAK20173.1| 752|Homo sapiens ATP binding cassette 7
protein.
Length = 752
Score = 233 bits (570), Expect = 3e-60
Identities = 140/420 (33%), Positives = 235/420 (55%), Gaps = 15/420 (3%)
Query: 105 FPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAF 164
+ G + AL + + +VA+T ++T+ I ++ + AG A + L + +TV F
Sbjct: 287 YKCGAQFALVTLGTLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYF 346
Query: 165 GGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDANK 224
E E QRY L+ E + + + L + + I F G I+ A++
Sbjct: 347 NNERYEAQRYDGFLKTYETASLKSTSTLAM-------LNFGQSAI-FSVGLTAIMVLASQ 398
Query: 225 PDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKIDCLS 284
T +G ++ + ++ + + A ++F+LL +I
Sbjct: 399 GIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIK--D 456
Query: 285 EAGSSPRRVIGE---ISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
+ +SP ++ + ++ ++VHF Y K+L G S + G+ VA+VG SG GKSTI
Sbjct: 457 KVMASPLQITPQTATVAFDNVHFEYIEGQ--KVLSGISFEVPAGKKVAIVGGSGSGKSTI 514
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEAT 401
++LL R Y+P +GS+ L G+N++ +++ LR ++GVV Q+ VLF TIY N+ G A+
Sbjct: 515 VRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISAS 574
Query: 402 SEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 461
E+VY VA++A H+ I +P+GY+T +GERG LSGG+KQR+AIAR++L++P V+L DE
Sbjct: 575 PEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDE 634
Query: 462 ATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELM 521
ATS+LD +E+ + A+ RT++ ++HRLST+V+ II +DQG + E+GTH L+
Sbjct: 635 ATSSLDSITEETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLL 694
Score = 178 bits (434), Expect = 8e-44
Identities = 95/227 (41%), Positives = 138/227 (60%), Gaps = 5/227 (2%)
Query: 907 SINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIE 966
+ ++V F Y Q +L GI V AGK VA+VG SG GKST+++L+ RFY+P G+I
Sbjct: 473 AFDNVHFEYIEG--QKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIY 530
Query: 967 LDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXX 1026
L G +I + ++L LR+ +GVV Q+ +LF T+ N+ YG+ S P +E
Sbjct: 531 LAGQNI-QDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASP--EEVYAVAKLAGL 587
Query: 1027 HNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAV 1086
H+ I+ +P GY+T KQRV IARA+++ P ++L DEATS+LD+ +E +
Sbjct: 588 HDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETI 647
Query: 1087 TEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELI 1133
A+ K RT I IAHRL+T+ DAD I VLD+GK+ E+G H L+
Sbjct: 648 LGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLL 694
>AF133659-1|AAD33045.1| 752|Homo sapiens ATP-binding cassette 7
iron transporter protein.
Length = 752
Score = 233 bits (570), Expect = 3e-60
Identities = 140/420 (33%), Positives = 235/420 (55%), Gaps = 15/420 (3%)
Query: 105 FPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAF 164
+ G + AL + + +VA+T ++T+ I ++ + AG A + L + +TV F
Sbjct: 287 YKCGAQFALVTLGTLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYF 346
Query: 165 GGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDANK 224
E E QRY L+ E + + + L + + I F G I+ A++
Sbjct: 347 NNERYEAQRYDGFLKTYETASLKSTSTLAM-------LNFGQSAI-FSVGLTAIMVLASQ 398
Query: 225 PDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKIDCLS 284
T +G ++ + ++ + + A ++F+LL +I
Sbjct: 399 GIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIK--D 456
Query: 285 EAGSSPRRVIGE---ISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
+ +SP ++ + ++ ++VHF Y K+L G S + G+ VA+VG SG GKSTI
Sbjct: 457 KVMASPLQITPQTATVAFDNVHFEYIEGQ--KVLSGISFEVPAGKKVAIVGGSGSGKSTI 514
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEAT 401
++LL R Y+P +GS+ L G+N++ +++ LR ++GVV Q+ VLF TIY N+ G A+
Sbjct: 515 VRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISAS 574
Query: 402 SEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 461
E+VY VA++A H+ I +P+GY+T +GERG LSGG+KQR+AIAR++L++P V+L DE
Sbjct: 575 PEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDE 634
Query: 462 ATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELM 521
ATS+LD +E+ + A+ RT++ ++HRLST+V+ II +DQG + E+GTH L+
Sbjct: 635 ATSSLDSITEETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLL 694
Score = 178 bits (434), Expect = 8e-44
Identities = 95/227 (41%), Positives = 138/227 (60%), Gaps = 5/227 (2%)
Query: 907 SINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIE 966
+ ++V F Y Q +L GI V AGK VA+VG SG GKST+++L+ RFY+P G+I
Sbjct: 473 AFDNVHFEYIEG--QKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIY 530
Query: 967 LDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXX 1026
L G +I + ++L LR+ +GVV Q+ +LF T+ N+ YG+ S P +E
Sbjct: 531 LAGQNI-QDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASP--EEVYAVAKLAGL 587
Query: 1027 HNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAV 1086
H+ I+ +P GY+T KQRV IARA+++ P ++L DEATS+LD+ +E +
Sbjct: 588 HDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETI 647
Query: 1087 TEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELI 1133
A+ K RT I IAHRL+T+ DAD I VLD+GK+ E+G H L+
Sbjct: 648 LGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLL 694
>AF078777-1|AAD47141.1| 748|Homo sapiens ABC transporter protein.
Length = 748
Score = 233 bits (569), Expect = 4e-60
Identities = 140/420 (33%), Positives = 235/420 (55%), Gaps = 15/420 (3%)
Query: 105 FPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAF 164
+ G + AL + + +VA+T ++T+ I ++ + AG A + L + +TV F
Sbjct: 283 YKCGAQFALVTLGTLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYF 342
Query: 165 GGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDANK 224
E E QRY L+ E + + + L + + I F G I+ A++
Sbjct: 343 NNERYEAQRYDGFLKTYETASLKSTSTLAM-------LNFGQSAI-FSVGLTAIMVLASQ 394
Query: 225 PDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKIDCLS 284
T +G ++ + ++ + + A ++F+LL +I
Sbjct: 395 GIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIK--D 452
Query: 285 EAGSSPRRVIGE---ISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
+ +SP ++ + ++ ++VHF Y K+L G S + G+ VA+VG SG GKSTI
Sbjct: 453 KVMASPLQITPQTATVAFDNVHFEYIEGQ--KVLSGISFEVPAGKKVAIVGGSGSGKSTI 510
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEAT 401
++LL R Y+P +GS+ L G+N++ +++ LR ++GVV Q+ VLF TIY N+ G A+
Sbjct: 511 VRLLFRFYEPQKGSIYLAGQNIQDVSLVSLRRAVGVVPQDAVLFHNTIYYNLLYGNISAS 570
Query: 402 SEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 461
E+VY VA++A H+ I +P+GY+T +GERG LSGG+KQR+AIAR++L++P V+L DE
Sbjct: 571 PEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDE 630
Query: 462 ATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELM 521
ATS+LD +E+ + A+ RT++ ++HRLST+V+ II +DQG + E+GTH L+
Sbjct: 631 ATSSLDSITEETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLL 690
Score = 177 bits (431), Expect = 2e-43
Identities = 95/227 (41%), Positives = 138/227 (60%), Gaps = 5/227 (2%)
Query: 907 SINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIE 966
+ ++V F Y Q +L GI V AGK VA+VG SG GKST+++L+ RFY+P G+I
Sbjct: 469 AFDNVHFEYIEG--QKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIY 526
Query: 967 LDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXX 1026
L G +I + ++L LR+ +GVV Q+ +LF T+ N+ YG+ S P +E
Sbjct: 527 LAGQNI-QDVSLVSLRRAVGVVPQDAVLFHNTIYYNLLYGNISASP--EEVYAVAKLAGL 583
Query: 1027 HNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAV 1086
H+ I+ +P GY+T KQRV IARA+++ P ++L DEATS+LD+ +E +
Sbjct: 584 HDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETI 643
Query: 1087 TEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELI 1133
A+ K RT I IAHRL+T+ DAD I VLD+GK+ E+G H L+
Sbjct: 644 LGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLL 690
>AK223300-1|BAD97020.1| 703|Homo sapiens transporter 2, ATP-binding
cassette, sub-family B isoform 1 variant protein.
Length = 703
Score = 231 bits (566), Expect = 8e-60
Identities = 156/490 (31%), Positives = 254/490 (51%), Gaps = 19/490 (3%)
Query: 44 IRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAVVSNLVGTSIICLCT 103
IR+ +++LRQD+ +F L S++S + + + V+ + +
Sbjct: 225 IREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGF 284
Query: 104 AFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREME-SYSQAGKQAEEVLKSVKTVV 162
+ +L L + MPF+I A + N + + +RE++ + ++AG+ E + ++TV
Sbjct: 285 MLSISPRLTLLSLLHMPFTIAAE-KVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVR 343
Query: 163 AFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDA 222
+ G E EV RYK LE RR L L VL + + G +
Sbjct: 344 SIGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQ------ 397
Query: 223 NKPDDERTYIIGIVLS-ITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKID 281
D E T G +LS + + + + TL + ++ + GAA +FS +D+ P +
Sbjct: 398 QMQDGELTQ--GSLLSFMIYQESVGSYVQTLVYIYGDMLSNV-GAAEKVFSYMDRQPNLP 454
Query: 282 CLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
S +P + G + +DV F+YP+R D +LKG + ++PGE ALVG +G GKST+
Sbjct: 455 --SPGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV 512
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEAT 401
LLQ L P G V LD + + +L S + VGQEPVLF G++ +NIA G
Sbjct: 513 AALLQNLNQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE 572
Query: 402 SEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 461
+ V A+ A+A +FI+ + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDE
Sbjct: 573 DDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDE 632
Query: 462 ATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELM 521
ATSALD E+ +Q R R L ++HRL + H+I+ + +G + + +L
Sbjct: 633 ATSALDVQCEQALQDWNSRGD--RAVLVIAHRLQAVQRAHQILVLQEGKLQKL---AQLQ 687
Query: 522 KAKGFYHKLV 531
+ + Y +LV
Sbjct: 688 EGQDLYSRLV 697
Score = 173 bits (421), Expect = 3e-42
Identities = 135/457 (29%), Positives = 221/457 (48%), Gaps = 16/457 (3%)
Query: 670 EIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTL 729
++G+F +E+ T G + +RLS DT + L ++L+ V + +S + +LTL
Sbjct: 237 DLGFF-QETKT-GELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTL 294
Query: 730 VSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFITR 789
+S +P + + + Q+ ++ ++A+ A + EAV ++TV+S+G E + R
Sbjct: 295 LSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSIGAEEHEVCR 354
Query: 790 FQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXX 849
+++AL ++ R L L + + L + G + G
Sbjct: 355 YKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMI 414
Query: 850 XX-MYGAYMLGQSLVYAPSFNSAKTCGA-RILSIINREPRIRTVDGLNDKQDWSASGNFS 907
G+Y+ Q+LVY + A ++ S ++R+P + + L + G
Sbjct: 415 YQESVGSYV--QTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPT---TLQGVVK 469
Query: 908 INDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIEL 967
DV F+YP R + +LKG+ + G+ ALVG +G GKSTV L+Q PT G + L
Sbjct: 470 FQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLNQPTGGQVLL 529
Query: 968 DGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXH 1027
D I++ L Q+ V QEP+LF ++ NIAYG S + D+
Sbjct: 530 DEKPISQ-YEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCED--DKVMAAAQAAHAD 586
Query: 1028 NFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVT 1087
+FI + G T+ KQR+ IARAL+R PR+L+LDEATSALD E+A+
Sbjct: 587 DFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQ 646
Query: 1088 EALDHAAKG-RTCITIAHRLTTIKDADIICVLDKGKI 1123
D ++G R + IAHRL ++ A I VL +GK+
Sbjct: 647 ---DWNSRGDRAVLVIAHRLQAVQRAHQILVLQEGKL 680
>AB005289-1|BAA28861.1| 752|Homo sapiens ABC transporter 7 protein
protein.
Length = 752
Score = 229 bits (561), Expect = 3e-59
Identities = 139/420 (33%), Positives = 233/420 (55%), Gaps = 15/420 (3%)
Query: 105 FPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAF 164
+ G + AL + + +VA+T + T+ I ++ + AG A + L + +TV
Sbjct: 287 YKCGAQFALVTLGTLGTYTAFTVAVTRWGTRFRIEMNKADNDAGNAAIDSLLNYETVKYI 346
Query: 165 GGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDANK 224
E E QRY L+ E + + + L + + I F G I+ A++
Sbjct: 347 NNERYEAQRYDGFLKTYETASLKSTSTLAM-------LNFGQSAI-FSVGLTAIMVLASQ 398
Query: 225 PDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKIDCLS 284
T +G ++ + ++ + + A ++F+LL +I
Sbjct: 399 GIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIK--D 456
Query: 285 EAGSSPRRVIGE---ISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
+ +SP ++ + ++ ++VHF Y K+L G S + G+ VA+VG SG GKSTI
Sbjct: 457 KVMASPLQITPQTATVAFDNVHFEYIEGQ--KVLSGISFEVPAGKKVAIVGGSGSGKSTI 514
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEAT 401
++LL R Y+P +GS+ L G+N++ +++ LR ++GVV Q+ VLF TIY N+ G A+
Sbjct: 515 VRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISAS 574
Query: 402 SEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 461
E+VY VA++A H+ I +P+GY+T +GERG LSGG+KQR+AIAR++L++P V+L DE
Sbjct: 575 PEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDE 634
Query: 462 ATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELM 521
ATS+LD +E+ + A+ RT++ ++HRLST+V+ II +DQG + E+GTH L+
Sbjct: 635 ATSSLDSITEETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLL 694
Score = 178 bits (434), Expect = 8e-44
Identities = 95/227 (41%), Positives = 138/227 (60%), Gaps = 5/227 (2%)
Query: 907 SINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIE 966
+ ++V F Y Q +L GI V AGK VA+VG SG GKST+++L+ RFY+P G+I
Sbjct: 473 AFDNVHFEYIEG--QKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIY 530
Query: 967 LDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXX 1026
L G +I + ++L LR+ +GVV Q+ +LF T+ N+ YG+ S P +E
Sbjct: 531 LAGQNI-QDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASP--EEVYAVAKLAGL 587
Query: 1027 HNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAV 1086
H+ I+ +P GY+T KQRV IARA+++ P ++L DEATS+LD+ +E +
Sbjct: 588 HDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETI 647
Query: 1087 TEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELI 1133
A+ K RT I IAHRL+T+ DAD I VLD+GK+ E+G H L+
Sbjct: 648 LGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLL 694
>BC000559-1|AAH00559.1| 842|Homo sapiens ATP-binding cassette,
sub-family B (MDR/TAP), member 6 protein.
Length = 842
Score = 229 bits (559), Expect = 6e-59
Identities = 143/411 (34%), Positives = 228/411 (55%), Gaps = 15/411 (3%)
Query: 119 MPFSIMASVALTNYQTKSSIREMESYSQAGK-QAEEVLKSVKTVVAFGGENIEVQRYK-S 176
M + ++ +T ++TK R M + A + +A + L + +TV + E+ EV+RY+ +
Sbjct: 421 MSLYLTLTIVVTEWRTKFR-RAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREA 479
Query: 177 LLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDANKPDDERTYIIGIV 236
+++ + L N V+ +G + G+ L A +++ + V
Sbjct: 480 IIKYQGLEWKSSASLVLLNQTQNLVIG-----LGLLAGSLLC---AYFVTEQKLQVGDYV 531
Query: 237 LSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKIDCLSEAGSSPRRVIGE 296
L T+ + + + + + T ++F LL + ++ L AG R G
Sbjct: 532 LFGTYIIQLY-MPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPL-RFQKGR 589
Query: 297 ISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSV 356
I E+VHFSY + L+ S + PG+++ALVG SG GKSTIL+LL R YD + G +
Sbjct: 590 IEFENVHFSYADGRET--LQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCI 647
Query: 357 KLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHE 416
++DG+++ + LRS +GVV Q+ VLF TI DNI G A +++V A+ A H+
Sbjct: 648 RIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHD 707
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQA 476
I P GY T +GERG LSGG+KQR+AIAR++L+ P ++LLDEATSALD +E+ +QA
Sbjct: 708 AIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQA 767
Query: 477 ALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFY 527
+L + RTT+ V+HRLST+VN +I+ + G I+E+G H L+ G Y
Sbjct: 768 SLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVY 818
Score = 183 bits (445), Expect = 4e-45
Identities = 128/406 (31%), Positives = 209/406 (51%), Gaps = 37/406 (9%)
Query: 761 ESAT-AIATEAVVSIKTVQSLGIESLFITRFQDALID-------ACAAVVKKSRWRGLVL 812
E+AT A A +++++ +TV+ ES + R+++A+I + A++V ++ + LV+
Sbjct: 446 ENATRARAVDSLLNFETVKYYNAESYEVERYREAIIKYQGLEWKSSASLVLLNQTQNLVI 505
Query: 813 GLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXXXXMYGAYMLGQSL------VYAP 866
GL ++ G++L A+ ++G Y++ + Y
Sbjct: 506 GL-----------GLLAGSLLCAY--FVTEQKLQVGDYVLFGTYIIQLYMPLNWFGTYYR 552
Query: 867 SFNSAKTCGARILSIINREPRIRTVDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKG 926
+ + ++ E ++ + G + G +V FSY L+
Sbjct: 553 MIQTNFIDMENMFDLLKEETEVKDLPGAGPLR--FQKGRIEFENVHFSYADGRET--LQD 608
Query: 927 IDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLG 986
+ V G+T+ALVG SG GKST+L+L+ RFYD ++G I +DG DI++ +T LR +G
Sbjct: 609 VSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQ-VTQASLRSHIG 667
Query: 987 VVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXX 1046
VV Q+ +LF+ T+A+NI YG + DE H+ I++ P+GY T
Sbjct: 668 VVPQDTVLFNDTIADNIRYGRVTAGN--DEVEAAAQAAGIHDAIMAFPEGYRTQVGERGL 725
Query: 1047 XXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRL 1106
KQRV IAR ++++P ++LLDEATSALD ++ERA+ +L RT I +AHRL
Sbjct: 726 KLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTTIVVAHRL 785
Query: 1107 TTIKDADIICVLDKGKIVEKGNHAELIGLKGHY---WQLSKQQNVT 1149
+T+ +AD I V+ G IVE+G H L+ G Y WQL + Q T
Sbjct: 786 STVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQQGQEET 831
>AK057026-1|BAB71347.1| 766|Homo sapiens protein ( Homo sapiens
cDNA FLJ32464 fis, clone SKNMC1000251, highly similar to
Homo sapiens MT-ABC transporter (MTABC) mRNA. ).
Length = 766
Score = 229 bits (559), Expect = 6e-59
Identities = 143/411 (34%), Positives = 228/411 (55%), Gaps = 15/411 (3%)
Query: 119 MPFSIMASVALTNYQTKSSIREMESYSQAGK-QAEEVLKSVKTVVAFGGENIEVQRYK-S 176
M + ++ +T ++TK R M + A + +A + L + +TV + E+ EV+RY+ +
Sbjct: 345 MSLYLTLTIVVTEWRTKFR-RAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREA 403
Query: 177 LLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDANKPDDERTYIIGIV 236
+++ + L N V+ +G + G+ L A +++ + V
Sbjct: 404 IIKYQGLEWKSSASLVLLNQTQNLVIG-----LGLLAGSLLC---AYFVTEQKLQVGDYV 455
Query: 237 LSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKIDCLSEAGSSPRRVIGE 296
L T+ + + + + + T ++F LL + ++ L AG R G
Sbjct: 456 LFGTYIIQLY-MPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPL-RFQKGR 513
Query: 297 ISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSV 356
I E+VHFSY + L+ S + PG+++ALVG SG GKSTIL+LL R YD + G +
Sbjct: 514 IEFENVHFSYADGRET--LQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCI 571
Query: 357 KLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHE 416
++DG+++ + LRS +GVV Q+ VLF TI DNI G A +++V A+ A H+
Sbjct: 572 RIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHD 631
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQA 476
I P GY T +GERG LSGG+KQR+AIAR++L+ P ++LLDEATSALD +E+ +QA
Sbjct: 632 AIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQA 691
Query: 477 ALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFY 527
+L + RTT+ V+HRLST+VN +I+ + G I+E+G H L+ G Y
Sbjct: 692 SLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVY 742
Score = 183 bits (445), Expect = 4e-45
Identities = 128/406 (31%), Positives = 209/406 (51%), Gaps = 37/406 (9%)
Query: 761 ESAT-AIATEAVVSIKTVQSLGIESLFITRFQDALID-------ACAAVVKKSRWRGLVL 812
E+AT A A +++++ +TV+ ES + R+++A+I + A++V ++ + LV+
Sbjct: 370 ENATRARAVDSLLNFETVKYYNAESYEVERYREAIIKYQGLEWKSSASLVLLNQTQNLVI 429
Query: 813 GLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXXXXMYGAYMLGQSL------VYAP 866
GL ++ G++L A+ ++G Y++ + Y
Sbjct: 430 GL-----------GLLAGSLLCAY--FVTEQKLQVGDYVLFGTYIIQLYMPLNWFGTYYR 476
Query: 867 SFNSAKTCGARILSIINREPRIRTVDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKG 926
+ + ++ E ++ + G + G +V FSY L+
Sbjct: 477 MIQTNFIDMENMFDLLKEETEVKDLPGAGPLR--FQKGRIEFENVHFSYADGRET--LQD 532
Query: 927 IDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLG 986
+ V G+T+ALVG SG GKST+L+L+ RFYD ++G I +DG DI++ +T LR +G
Sbjct: 533 VSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQ-VTQASLRSHIG 591
Query: 987 VVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXX 1046
VV Q+ +LF+ T+A+NI YG + DE H+ I++ P+GY T
Sbjct: 592 VVPQDTVLFNDTIADNIRYGRVTAGN--DEVEAAAQAAGIHDAIMAFPEGYRTQVGERGL 649
Query: 1047 XXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRL 1106
KQRV IAR ++++P ++LLDEATSALD ++ERA+ +L RT I +AHRL
Sbjct: 650 KLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTTIVVAHRL 709
Query: 1107 TTIKDADIICVLDKGKIVEKGNHAELIGLKGHY---WQLSKQQNVT 1149
+T+ +AD I V+ G IVE+G H L+ G Y WQL + Q T
Sbjct: 710 STVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQQGQEET 755
>AJ289233-1|CAB95766.2| 842|Homo sapiens ABC transporter umat
protein.
Length = 842
Score = 229 bits (559), Expect = 6e-59
Identities = 143/411 (34%), Positives = 228/411 (55%), Gaps = 15/411 (3%)
Query: 119 MPFSIMASVALTNYQTKSSIREMESYSQAGK-QAEEVLKSVKTVVAFGGENIEVQRYK-S 176
M + ++ +T ++TK R M + A + +A + L + +TV + E+ EV+RY+ +
Sbjct: 421 MSLYLTLTIVVTEWRTKFR-RAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREA 479
Query: 177 LLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDANKPDDERTYIIGIV 236
+++ + L N V+ +G + G+ L A +++ + V
Sbjct: 480 IIKYQGLEWKSSASLVLLNQTQNLVIG-----LGLLAGSLLC---AYFVTEQKLQVGDYV 531
Query: 237 LSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKIDCLSEAGSSPRRVIGE 296
L T+ + + + + + T ++F LL + ++ L AG R G
Sbjct: 532 LFGTYIIQLY-MPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPL-RFQKGR 589
Query: 297 ISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSV 356
I E+VHFSY + L+ S + PG+++ALVG SG GKSTIL+LL R YD + G +
Sbjct: 590 IEFENVHFSYADGRET--LQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCI 647
Query: 357 KLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHE 416
++DG+++ + LRS +GVV Q+ VLF TI DNI G A +++V A+ A H+
Sbjct: 648 RIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHD 707
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQA 476
I P GY T +GERG LSGG+KQR+AIAR++L+ P ++LLDEATSALD +E+ +QA
Sbjct: 708 AIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQA 767
Query: 477 ALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFY 527
+L + RTT+ V+HRLST+VN +I+ + G I+E+G H L+ G Y
Sbjct: 768 SLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVY 818
Score = 183 bits (445), Expect = 4e-45
Identities = 128/406 (31%), Positives = 209/406 (51%), Gaps = 37/406 (9%)
Query: 761 ESAT-AIATEAVVSIKTVQSLGIESLFITRFQDALID-------ACAAVVKKSRWRGLVL 812
E+AT A A +++++ +TV+ ES + R+++A+I + A++V ++ + LV+
Sbjct: 446 ENATRARAVDSLLNFETVKYYNAESYEVERYREAIIKYQGLEWKSSASLVLLNQTQNLVI 505
Query: 813 GLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXXXXMYGAYMLGQSL------VYAP 866
GL ++ G++L A+ ++G Y++ + Y
Sbjct: 506 GL-----------GLLAGSLLCAY--FVTEQKLQVGDYVLFGTYIIQLYMPLNWFGTYYR 552
Query: 867 SFNSAKTCGARILSIINREPRIRTVDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKG 926
+ + ++ E ++ + G + G +V FSY L+
Sbjct: 553 MIQTNFIDMENMFDLLKEETEVKDLPGAGPLR--FQKGRIEFENVHFSYADGRET--LQD 608
Query: 927 IDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLG 986
+ V G+T+ALVG SG GKST+L+L+ RFYD ++G I +DG DI++ +T LR +G
Sbjct: 609 VSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQ-VTQASLRSHIG 667
Query: 987 VVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXX 1046
VV Q+ +LF+ T+A+NI YG + DE H+ I++ P+GY T
Sbjct: 668 VVPQDTVLFNDTIADNIRYGRVTAGN--DEVEAAAQAAGIHDAIMAFPEGYRTQVGERGL 725
Query: 1047 XXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRL 1106
KQRV IAR ++++P ++LLDEATSALD ++ERA+ +L RT I +AHRL
Sbjct: 726 KLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTTIVVAHRL 785
Query: 1107 TTIKDADIICVLDKGKIVEKGNHAELIGLKGHY---WQLSKQQNVT 1149
+T+ +AD I V+ G IVE+G H L+ G Y WQL + Q T
Sbjct: 786 STVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQQGQEET 831
>AF308472-1|AAG33617.1| 896|Homo sapiens ATP-binding cassette
half-transporter protein.
Length = 896
Score = 229 bits (559), Expect = 6e-59
Identities = 143/411 (34%), Positives = 228/411 (55%), Gaps = 15/411 (3%)
Query: 119 MPFSIMASVALTNYQTKSSIREMESYSQAGK-QAEEVLKSVKTVVAFGGENIEVQRYK-S 176
M + ++ +T ++TK R M + A + +A + L + +TV + E+ EV+RY+ +
Sbjct: 475 MSLYLTLTIVVTEWRTKFR-RAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREA 533
Query: 177 LLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDANKPDDERTYIIGIV 236
+++ + L N V+ +G + G+ L A +++ + V
Sbjct: 534 IIKYQGLEWKSSASLVLLNQTQNLVIG-----LGLLAGSLLC---AYFVTEQKLQVGDYV 585
Query: 237 LSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKIDCLSEAGSSPRRVIGE 296
L T+ + + + + + T ++F LL + ++ L AG R G
Sbjct: 586 LFGTYIIQLY-MPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPL-RFQKGR 643
Query: 297 ISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSV 356
I E+VHFSY + L+ S + PG+++ALVG SG GKSTIL+LL R YD + G +
Sbjct: 644 IEFENVHFSYADGRET--LQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCI 701
Query: 357 KLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHE 416
++DG+++ + LRS +GVV Q+ VLF TI DNI G A +++V A+ A H+
Sbjct: 702 RIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHD 761
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQA 476
I P GY T +GERG LSGG+KQR+AIAR++L+ P ++LLDEATSALD +E+ +QA
Sbjct: 762 AIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQA 821
Query: 477 ALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFY 527
+L + RTT+ V+HRLST+VN +I+ + G I+E+G H L+ G Y
Sbjct: 822 SLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVY 872
Score = 183 bits (445), Expect = 4e-45
Identities = 128/406 (31%), Positives = 209/406 (51%), Gaps = 37/406 (9%)
Query: 761 ESAT-AIATEAVVSIKTVQSLGIESLFITRFQDALID-------ACAAVVKKSRWRGLVL 812
E+AT A A +++++ +TV+ ES + R+++A+I + A++V ++ + LV+
Sbjct: 500 ENATRARAVDSLLNFETVKYYNAESYEVERYREAIIKYQGLEWKSSASLVLLNQTQNLVI 559
Query: 813 GLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXXXXMYGAYMLGQSL------VYAP 866
GL ++ G++L A+ ++G Y++ + Y
Sbjct: 560 GL-----------GLLAGSLLCAY--FVTEQKLQVGDYVLFGTYIIQLYMPLNWFGTYYR 606
Query: 867 SFNSAKTCGARILSIINREPRIRTVDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKG 926
+ + ++ E ++ + G + G +V FSY L+
Sbjct: 607 MIQTNFIDMENMFDLLKEETEVKDLPGAGPLR--FQKGRIEFENVHFSYADGRET--LQD 662
Query: 927 IDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLG 986
+ V G+T+ALVG SG GKST+L+L+ RFYD ++G I +DG DI++ +T LR +G
Sbjct: 663 VSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQ-VTQASLRSHIG 721
Query: 987 VVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXX 1046
VV Q+ +LF+ T+A+NI YG + DE H+ I++ P+GY T
Sbjct: 722 VVPQDTVLFNDTIADNIRYGRVTAGN--DEVEAAAQAAGIHDAIMAFPEGYRTQVGERGL 779
Query: 1047 XXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRL 1106
KQRV IAR ++++P ++LLDEATSALD ++ERA+ +L RT I +AHRL
Sbjct: 780 KLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTTIVVAHRL 839
Query: 1107 TTIKDADIICVLDKGKIVEKGNHAELIGLKGHY---WQLSKQQNVT 1149
+T+ +AD I V+ G IVE+G H L+ G Y WQL + Q T
Sbjct: 840 STVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQQGQEET 885
>AF076775-1|AAF75107.1| 842|Homo sapiens MT-ABC transporter
protein.
Length = 842
Score = 229 bits (559), Expect = 6e-59
Identities = 143/411 (34%), Positives = 228/411 (55%), Gaps = 15/411 (3%)
Query: 119 MPFSIMASVALTNYQTKSSIREMESYSQAGK-QAEEVLKSVKTVVAFGGENIEVQRYK-S 176
M + ++ +T ++TK R M + A + +A + L + +TV + E+ EV+RY+ +
Sbjct: 421 MSLYLTLTIVVTEWRTKFR-RAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREA 479
Query: 177 LLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDANKPDDERTYIIGIV 236
+++ + L N V+ +G + G+ L A +++ + V
Sbjct: 480 IIKYQGLEWKSSASLVLLNQTQNLVIG-----LGLLAGSLLC---AYFVTEQKLQVGDYV 531
Query: 237 LSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKIDCLSEAGSSPRRVIGE 296
L T+ + + + + + T ++F LL + ++ L AG R G
Sbjct: 532 LFGTYIIQLY-MPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPL-RFQKGR 589
Query: 297 ISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSV 356
I E+VHFSY + L+ S + PG+++ALVG SG GKSTIL+LL R YD + G +
Sbjct: 590 IEFENVHFSYADGRET--LQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCI 647
Query: 357 KLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHE 416
++DG+++ + LRS +GVV Q+ VLF TI DNI G A +++V A+ A H+
Sbjct: 648 RIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHD 707
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQA 476
I P GY T +GERG LSGG+KQR+AIAR++L+ P ++LLDEATSALD +E+ +QA
Sbjct: 708 AIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQA 767
Query: 477 ALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFY 527
+L + RTT+ V+HRLST+VN +I+ + G I+E+G H L+ G Y
Sbjct: 768 SLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVY 818
Score = 183 bits (445), Expect = 4e-45
Identities = 128/406 (31%), Positives = 209/406 (51%), Gaps = 37/406 (9%)
Query: 761 ESAT-AIATEAVVSIKTVQSLGIESLFITRFQDALID-------ACAAVVKKSRWRGLVL 812
E+AT A A +++++ +TV+ ES + R+++A+I + A++V ++ + LV+
Sbjct: 446 ENATRARAVDSLLNFETVKYYNAESYEVERYREAIIKYQGLEWKSSASLVLLNQTQNLVI 505
Query: 813 GLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXXXXMYGAYMLGQSL------VYAP 866
GL ++ G++L A+ ++G Y++ + Y
Sbjct: 506 GL-----------GLLAGSLLCAY--FVTEQKLQVGDYVLFGTYIIQLYMPLNWFGTYYR 552
Query: 867 SFNSAKTCGARILSIINREPRIRTVDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKG 926
+ + ++ E ++ + G + G +V FSY L+
Sbjct: 553 MIQTNFIDMENMFDLLKEETEVKDLPGAGPLR--FQKGRIEFENVHFSYADGRET--LQD 608
Query: 927 IDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLG 986
+ V G+T+ALVG SG GKST+L+L+ RFYD ++G I +DG DI++ +T LR +G
Sbjct: 609 VSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQ-VTQASLRSHIG 667
Query: 987 VVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXX 1046
VV Q+ +LF+ T+A+NI YG + DE H+ I++ P+GY T
Sbjct: 668 VVPQDTVLFNDTIADNIRYGRVTAGN--DEVEAAAQAAGIHDAIMAFPEGYRTQVGERGL 725
Query: 1047 XXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRL 1106
KQRV IAR ++++P ++LLDEATSALD ++ERA+ +L RT I +AHRL
Sbjct: 726 KLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTTIVVAHRL 785
Query: 1107 TTIKDADIICVLDKGKIVEKGNHAELIGLKGHY---WQLSKQQNVT 1149
+T+ +AD I V+ G IVE+G H L+ G Y WQL + Q T
Sbjct: 786 STVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQQGQEET 831
>AF070598-1|AAC28653.1| 511|Homo sapiens ABC transporter protein.
Length = 511
Score = 229 bits (559), Expect = 6e-59
Identities = 143/411 (34%), Positives = 228/411 (55%), Gaps = 15/411 (3%)
Query: 119 MPFSIMASVALTNYQTKSSIREMESYSQAGK-QAEEVLKSVKTVVAFGGENIEVQRYK-S 176
M + ++ +T ++TK R M + A + +A + L + +TV + E+ EV+RY+ +
Sbjct: 90 MSLYLTLTIVVTEWRTKFR-RAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREA 148
Query: 177 LLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDANKPDDERTYIIGIV 236
+++ + L N V+ +G + G+ L A +++ + V
Sbjct: 149 IIKYQGLEWKSSASLVLLNQTQNLVIG-----LGLLAGSLLC---AYFVTEQKLQVGDYV 200
Query: 237 LSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKIDCLSEAGSSPRRVIGE 296
L T+ + + + + + T ++F LL + ++ L AG R G
Sbjct: 201 LFGTYIIQLY-MPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPL-RFQKGR 258
Query: 297 ISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSV 356
I E+VHFSY + L+ S + PG+++ALVG SG GKSTIL+LL R YD + G +
Sbjct: 259 IEFENVHFSYADGRET--LQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCI 316
Query: 357 KLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHE 416
++DG+++ + LRS +GVV Q+ VLF TI DNI G A +++V A+ A H+
Sbjct: 317 RIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHD 376
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQA 476
I P GY T +GERG LSGG+KQR+AIAR++L+ P ++LLDEATSALD +E+ +QA
Sbjct: 377 AIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQA 436
Query: 477 ALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFY 527
+L + RTT+ V+HRLST+VN +I+ + G I+E+G H L+ G Y
Sbjct: 437 SLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVY 487
Score = 183 bits (445), Expect = 4e-45
Identities = 128/406 (31%), Positives = 209/406 (51%), Gaps = 37/406 (9%)
Query: 761 ESAT-AIATEAVVSIKTVQSLGIESLFITRFQDALID-------ACAAVVKKSRWRGLVL 812
E+AT A A +++++ +TV+ ES + R+++A+I + A++V ++ + LV+
Sbjct: 115 ENATRARAVDSLLNFETVKYYNAESYEVERYREAIIKYQGLEWKSSASLVLLNQTQNLVI 174
Query: 813 GLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXXXXMYGAYMLGQSL------VYAP 866
GL ++ G++L A+ ++G Y++ + Y
Sbjct: 175 GL-----------GLLAGSLLCAY--FVTEQKLQVGDYVLFGTYIIQLYMPLNWFGTYYR 221
Query: 867 SFNSAKTCGARILSIINREPRIRTVDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKG 926
+ + ++ E ++ + G + G +V FSY L+
Sbjct: 222 MIQTNFIDMENMFDLLKEETEVKDLPGAGPLR--FQKGRIEFENVHFSYADGRET--LQD 277
Query: 927 IDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLG 986
+ V G+T+ALVG SG GKST+L+L+ RFYD ++G I +DG DI++ +T LR +G
Sbjct: 278 VSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQ-VTQASLRSHIG 336
Query: 987 VVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXX 1046
VV Q+ +LF+ T+A+NI YG + DE H+ I++ P+GY T
Sbjct: 337 VVPQDTVLFNDTIADNIRYGRVTAGN--DEVEAAAQAAGIHDAIMAFPEGYRTQVGERGL 394
Query: 1047 XXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRL 1106
KQRV IAR ++++P ++LLDEATSALD ++ERA+ +L RT I +AHRL
Sbjct: 395 KLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTTIVVAHRL 454
Query: 1107 TTIKDADIICVLDKGKIVEKGNHAELIGLKGHY---WQLSKQQNVT 1149
+T+ +AD I V+ G IVE+G H L+ G Y WQL + Q T
Sbjct: 455 STVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQQGQEET 500
>AB039371-1|BAA96733.1| 842|Homo sapiens mitochondrial ABC
transporter 3 protein.
Length = 842
Score = 229 bits (559), Expect = 6e-59
Identities = 143/411 (34%), Positives = 228/411 (55%), Gaps = 15/411 (3%)
Query: 119 MPFSIMASVALTNYQTKSSIREMESYSQAGK-QAEEVLKSVKTVVAFGGENIEVQRYK-S 176
M + ++ +T ++TK R M + A + +A + L + +TV + E+ EV+RY+ +
Sbjct: 421 MSLYLTLTIVVTEWRTKFR-RAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREA 479
Query: 177 LLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDANKPDDERTYIIGIV 236
+++ + L N V+ +G + G+ L A +++ + V
Sbjct: 480 IIKYQGLEWKSSASLVLLNQTQNLVIG-----LGLLAGSLLC---AYFVTEQKLQVGDYV 531
Query: 237 LSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKIDCLSEAGSSPRRVIGE 296
L T+ + + + + + T ++F LL + ++ L AG R G
Sbjct: 532 LFGTYIIQLY-MPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPL-RFQKGR 589
Query: 297 ISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSV 356
I E+VHFSY + L+ S + PG+++ALVG SG GKSTIL+LL R YD + G +
Sbjct: 590 IEFENVHFSYADGRET--LQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCI 647
Query: 357 KLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHE 416
++DG+++ + LRS +GVV Q+ VLF TI DNI G A +++V A+ A H+
Sbjct: 648 RIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHD 707
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQA 476
I P GY T +GERG LSGG+KQR+AIAR++L+ P ++LLDEATSALD +E+ +QA
Sbjct: 708 AIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQA 767
Query: 477 ALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFY 527
+L + RTT+ V+HRLST+VN +I+ + G I+E+G H L+ G Y
Sbjct: 768 SLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVY 818
Score = 183 bits (445), Expect = 4e-45
Identities = 128/406 (31%), Positives = 209/406 (51%), Gaps = 37/406 (9%)
Query: 761 ESAT-AIATEAVVSIKTVQSLGIESLFITRFQDALID-------ACAAVVKKSRWRGLVL 812
E+AT A A +++++ +TV+ ES + R+++A+I + A++V ++ + LV+
Sbjct: 446 ENATRARAVDSLLNFETVKYYNAESYEVERYREAIIKYQGLEWKSSASLVLLNQTQNLVI 505
Query: 813 GLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXXXXMYGAYMLGQSL------VYAP 866
GL ++ G++L A+ ++G Y++ + Y
Sbjct: 506 GL-----------GLLAGSLLCAY--FVTEQKLQVGDYVLFGTYIIQLYMPLNWFGTYYR 552
Query: 867 SFNSAKTCGARILSIINREPRIRTVDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKG 926
+ + ++ E ++ + G + G +V FSY L+
Sbjct: 553 MIQTNFIDMENMFDLLKEETEVKDLPGAGPLR--FQKGRIEFENVHFSYADGRET--LQD 608
Query: 927 IDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLG 986
+ V G+T+ALVG SG GKST+L+L+ RFYD ++G I +DG DI++ +T LR +G
Sbjct: 609 VSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQ-VTQASLRSHIG 667
Query: 987 VVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXX 1046
VV Q+ +LF+ T+A+NI YG + DE H+ I++ P+GY T
Sbjct: 668 VVPQDTVLFNDTIADNIRYGRVTAGN--DEVEAAAQAAGIHDAIMAFPEGYRTQVGERGL 725
Query: 1047 XXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRL 1106
KQRV IAR ++++P ++LLDEATSALD ++ERA+ +L RT I +AHRL
Sbjct: 726 KLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTTIVVAHRL 785
Query: 1107 TTIKDADIICVLDKGKIVEKGNHAELIGLKGHY---WQLSKQQNVT 1149
+T+ +AD I V+ G IVE+G H L+ G Y WQL + Q T
Sbjct: 786 STVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQQGQEET 831
>BC043423-1|AAH43423.1| 301|Homo sapiens ABCB6 protein protein.
Length = 301
Score = 225 bits (550), Expect = 7e-58
Identities = 116/259 (44%), Positives = 166/259 (64%), Gaps = 3/259 (1%)
Query: 269 SIFSLLDKHPKIDCLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESV 328
++F LL + ++ L AG R G I E+VHFSY + L+ S + PG+++
Sbjct: 22 NMFDLLKEETEVKDLPGAGPL-RFQKGRIEFENVHFSYADGRET--LQDVSFTVMPGQTL 78
Query: 329 ALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGT 388
ALVG SG GKSTIL+LL R YD + G +++DG+++ + LRS +GVV Q+ VLF T
Sbjct: 79 ALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQASLRSHIGVVPQDTVLFNDT 138
Query: 389 IYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIAR 448
I DNI G A +++V A+ A H+ I P GY T +GERG LSGG+KQR+AIAR
Sbjct: 139 IADNIRYGRVTAGNDEVEAAAQAAGIHDAIMAFPEGYRTQVGERGLKLSGGEKQRVAIAR 198
Query: 449 SLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQ 508
++L+ P ++LLDEATSALD +E+ +QA+L + RTT+ V+HRLST+VN +I+ +
Sbjct: 199 TILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTTIVVAHRLSTVVNADQILVIKD 258
Query: 509 GTIIEQGTHVELMKAKGFY 527
G I+E+G H L+ G Y
Sbjct: 259 GCIVERGRHEALLSRGGVY 277
Score = 182 bits (444), Expect = 5e-45
Identities = 102/249 (40%), Positives = 145/249 (58%), Gaps = 8/249 (3%)
Query: 904 GNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTG 963
G +V FSY L+ + V G+T+ALVG SG GKST+L+L+ RFYD ++G
Sbjct: 47 GRIEFENVHFSYADGRET--LQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSG 104
Query: 964 NIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXX 1023
I +DG DI++ +T LR +GVV Q+ +LF+ T+A+NI YG + DE
Sbjct: 105 CIRIDGQDISQ-VTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGN--DEVEAAAQA 161
Query: 1024 XXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSE 1083
H+ I++ P+GY T KQRV IAR ++++P ++LLDEATSALD ++E
Sbjct: 162 AGIHDAIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNE 221
Query: 1084 RAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHY---W 1140
RA+ +L RT I +AHRL+T+ +AD I V+ G IVE+G H L+ G Y W
Sbjct: 222 RAIQASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMW 281
Query: 1141 QLSKQQNVT 1149
QL + Q T
Sbjct: 282 QLQQGQEET 290
>AF176984-1|AAD50509.1| 372|Homo sapiens TAP2 protein protein.
Length = 372
Score = 223 bits (545), Expect = 3e-57
Identities = 137/376 (36%), Positives = 209/376 (55%), Gaps = 15/376 (3%)
Query: 138 IREME-SYSQAGKQAEEVLKSVKTVVAFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGN 196
+RE++ + ++AG+ E + ++TV +FG E EV RYK LE RR L L
Sbjct: 3 LREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYL 62
Query: 197 GFNWVLTYSLNTIGFMYGTRLIIEDANKPDDERTYIIGIVLS-ITFSVYMATQSITLCVP 255
VL + + G + D E T G +LS + + + + TL
Sbjct: 63 LVRRVLHLGVQMLMLSCGLQ------QMQDGELTQ--GSLLSFMIYQESVGSYVQTLVYI 114
Query: 256 HMEVFATARGAAASIFSLLDKHPKIDCLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKIL 315
+ ++ + GAA +FS +D+ P + S +P + G + +DV F+YP+R D +L
Sbjct: 115 YGDMLSNV-GAAEKVFSYMDRQPNLP--SPGTLAPTTLQGVVKFQDVSFAYPNRPDRPVL 171
Query: 316 KGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSL 375
KG + ++PGE ALVG +G GKST+ LLQ LY P G V LD + + +L S +
Sbjct: 172 KGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQV 231
Query: 376 GVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGAS 435
VGQEPVLF G++ +NIA G + V A+ A+A +FI+ + +G T +GE+G+
Sbjct: 232 VSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQ 291
Query: 436 LSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLS 495
L+ GQKQR+AIAR+L+R+P VL+LDEATSALD E+ +Q R RT L ++HRL
Sbjct: 292 LAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQDWNSRGD--RTVLVIAHRLQ 349
Query: 496 TIVNCHRIICMDQGTI 511
T+ H+I+ + +G +
Sbjct: 350 TVQRAHQILVLQEGKL 365
Score = 157 bits (382), Expect = 2e-37
Identities = 118/370 (31%), Positives = 180/370 (48%), Gaps = 14/370 (3%)
Query: 757 REAMESATAIATEAVVSIKTVQSLGIESLFITRFQDALIDACAAVVKKSRWRGLVLGLCI 816
++A+ A + EAV ++TV+S G E + R+++AL ++ R L L +
Sbjct: 7 QDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRR 66
Query: 817 YVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXXXX-MYGAYMLGQSLVYAPSFNSAKTCG 875
+ L + G + G G+Y+ Q+LVY +
Sbjct: 67 VLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESVGSYV--QTLVYIYGDMLSNVGA 124
Query: 876 A-RILSIINREPRIRTVDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAG 934
A ++ S ++R+P + + L + G DV F+YP R + +LKG+ + G
Sbjct: 125 AEKVFSYMDRQPNLPSPGTLAPT---TLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPG 181
Query: 935 KTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPIL 994
+ ALVG +G GKSTV L+Q Y PT G + LD I++ L Q+ V QEP+L
Sbjct: 182 EVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQ-YEHCYLHSQVVSVGQEPVL 240
Query: 995 FDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQ 1054
F ++ NIAYG S + D+ +FI + G T+ KQ
Sbjct: 241 FSGSVRNNIAYGLQSCED--DKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQ 298
Query: 1055 RVCIARALIRSPRLLLLDEATSALDANSERAVTEALDHAAKG-RTCITIAHRLTTIKDAD 1113
R+ IARAL+R PR+L+LDEATSALD E+A+ D ++G RT + IAHRL T++ A
Sbjct: 299 RLAIARALVRDPRVLILDEATSALDVQCEQALQ---DWNSRGDRTVLVIAHRLQTVQRAH 355
Query: 1114 IICVLDKGKI 1123
I VL +GK+
Sbjct: 356 QILVLQEGKL 365
>AK172812-1|BAD18782.1| 571|Homo sapiens protein ( Homo sapiens
cDNA FLJ23973 fis, clone HEP18305, highly similar to
ATP-binding cassette, sub-family B, member 6,
mitochondrial precursor. ).
Length = 571
Score = 223 bits (544), Expect = 4e-57
Identities = 141/411 (34%), Positives = 226/411 (54%), Gaps = 15/411 (3%)
Query: 119 MPFSIMASVALTNYQTKSSIREMESYSQAGK-QAEEVLKSVKTVVAFGGENIEVQRYK-S 176
M + ++ +T ++TK R M + A + +A + L + +TV + E+ EV+RY+ +
Sbjct: 150 MSLYLTLTIVVTEWRTKFR-RAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREA 208
Query: 177 LLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDANKPDDERTYIIGIV 236
+++ + L N V+ +G + G+ L A +++ + V
Sbjct: 209 IIKYQGLEWKSSASLVLLNQTQNLVIG-----LGLLAGSLLC---AYFVTEQKLQVGDYV 260
Query: 237 LSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKIDCLSEAGSSPRRVIGE 296
L T+ + + + + + T ++F LL + ++ L AG R G
Sbjct: 261 LFGTYIIQLY-MPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPL-RFQKGR 318
Query: 297 ISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSV 356
I E+VHFSY + L+ S + P +++ALVG SG GKSTIL+LL YD + G +
Sbjct: 319 IEFENVHFSYADGRET--LQDVSFTVMPEQTLALVGPSGAGKSTILRLLFLFYDISSGCI 376
Query: 357 KLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHE 416
++DG+++ + LRS +GVV Q+ VLF TI DNI G A +++V A+ A H+
Sbjct: 377 RIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHD 436
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQA 476
I P GY T +GERG LSGG+KQR+AIAR++L+ P ++LLDEATSALD +E+ +QA
Sbjct: 437 AIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQA 496
Query: 477 ALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFY 527
+L + RTT+ V+HRLST+VN +I+ + G I+E+G H L+ G Y
Sbjct: 497 SLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVY 547
Score = 177 bits (430), Expect = 2e-43
Identities = 126/406 (31%), Positives = 207/406 (50%), Gaps = 37/406 (9%)
Query: 761 ESAT-AIATEAVVSIKTVQSLGIESLFITRFQDALID-------ACAAVVKKSRWRGLVL 812
E+AT A A +++++ +TV+ ES + R+++A+I + A++V ++ + LV+
Sbjct: 175 ENATRARAVDSLLNFETVKYYNAESYEVERYREAIIKYQGLEWKSSASLVLLNQTQNLVI 234
Query: 813 GLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXXXXMYGAYMLGQSL------VYAP 866
GL ++ G++L A+ ++G Y++ + Y
Sbjct: 235 GL-----------GLLAGSLLCAY--FVTEQKLQVGDYVLFGTYIIQLYMPLNWFGTYYR 281
Query: 867 SFNSAKTCGARILSIINREPRIRTVDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKG 926
+ + ++ E ++ + G + G +V FSY L+
Sbjct: 282 MIQTNFIDMENMFDLLKEETEVKDLPGAGPLR--FQKGRIEFENVHFSYADGRET--LQD 337
Query: 927 IDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLG 986
+ V +T+ALVG SG GKST+L+L+ FYD ++G I +DG DI++ +T LR +G
Sbjct: 338 VSFTVMPEQTLALVGPSGAGKSTILRLLFLFYDISSGCIRIDGQDISQ-VTQASLRSHIG 396
Query: 987 VVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXX 1046
VV Q+ +LF+ T+A+NI YG + DE H+ I++ P+GY T
Sbjct: 397 VVPQDTVLFNDTIADNIRYGRVTAGN--DEVEAAAQAAGIHDAIMAFPEGYRTQVGERGL 454
Query: 1047 XXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRL 1106
KQRV IAR ++++P ++LLDEATSALD ++ERA+ +L RT I +AHRL
Sbjct: 455 KLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTTIVVAHRL 514
Query: 1107 TTIKDADIICVLDKGKIVEKGNHAELIGLKGHY---WQLSKQQNVT 1149
+T+ +AD I V+ G IVE+G H L+ G Y WQL + Q T
Sbjct: 515 STVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQQGQEET 560
>AF105151-1|AAD12059.1| 653|Homo sapiens Tap2 transporter isoform
protein.
Length = 653
Score = 218 bits (533), Expect = 8e-56
Identities = 144/431 (33%), Positives = 229/431 (53%), Gaps = 14/431 (3%)
Query: 44 IRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAVVSNLVGTSIICLCT 103
IR+ +++LRQD+ +F L S++S + + + V+ + +
Sbjct: 225 IREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGF 284
Query: 104 AFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREME-SYSQAGKQAEEVLKSVKTVV 162
+ +L L + MPF+I A + N + + +RE++ + ++AG+ E + ++TV
Sbjct: 285 MLSISPRLTLLSLLHMPFTIAAE-KVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVR 343
Query: 163 AFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDA 222
+FG E EV RYK LE RR L L VL + + G + +
Sbjct: 344 SFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLIRRVLHLGVQMLMLSCGLQQM---- 399
Query: 223 NKPDDERTYIIGIVLS-ITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKID 281
D E T G +LS + + + + TL + ++ + GAA +FS +D+ P +
Sbjct: 400 --QDGELTQ--GSLLSFMIYQESVGSYVQTLVYIYGDMLSNV-GAAEKVFSYMDRQPNLP 454
Query: 282 CLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
S +P + G + +DV F+YP+R D +LKG + ++PGE ALVG +G GKST+
Sbjct: 455 --SPGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV 512
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEAT 401
LLQ LY P G V LD + + +L S + VGQEPVLF G++ +NIA G
Sbjct: 513 AALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE 572
Query: 402 SEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 461
+ V A+ A+A +FI+ + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDE
Sbjct: 573 DDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDE 632
Query: 462 ATSALDPHSEK 472
ATSALD E+
Sbjct: 633 ATSALDVQCEQ 643
Score = 161 bits (390), Expect = 2e-38
Identities = 123/420 (29%), Positives = 200/420 (47%), Gaps = 12/420 (2%)
Query: 670 EIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTL 729
++G+F +E+ T G + +RLS DT + L ++L+ V + +S + +LTL
Sbjct: 237 DLGFF-QETKT-GELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTL 294
Query: 730 VSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFITR 789
+S +P + + + Q+ ++ ++A+ A + EAV ++TV+S G E + R
Sbjct: 295 LSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCR 354
Query: 790 FQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXX 849
+++AL ++ R L L + + L + G + G
Sbjct: 355 YKEALEQCRQLYWRRDLERALYLLIRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMI 414
Query: 850 XX-MYGAYMLGQSLVYAPSFNSAKTCGA-RILSIINREPRIRTVDGLNDKQDWSASGNFS 907
G+Y+ Q+LVY + A ++ S ++R+P + + L + G
Sbjct: 415 YQESVGSYV--QTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPT---TLQGVVK 469
Query: 908 INDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIEL 967
DV F+YP R + +LKG+ + G+ ALVG +G GKSTV L+Q Y PT G + L
Sbjct: 470 FQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLL 529
Query: 968 DGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXH 1027
D I++ L Q+ V QEP+LF ++ NIAYG S + D+
Sbjct: 530 DEKPISQ-YEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCED--DKVMAAAQAAHAD 586
Query: 1028 NFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVT 1087
+FI + G T+ KQR+ IARAL+R PR+L+LDEATSALD E+A T
Sbjct: 587 DFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQAKT 646
>BX682530-5|CAI41936.1| 653|Homo sapiens transporter 2 ATP-binding
cassette sub-family B (MDR/TAP) protein.
Length = 653
Score = 218 bits (532), Expect = 1e-55
Identities = 144/431 (33%), Positives = 228/431 (52%), Gaps = 14/431 (3%)
Query: 44 IRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAVVSNLVGTSIICLCT 103
IR+ +++LRQD+ +F L S++S + + + V+ + +
Sbjct: 225 IREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGF 284
Query: 104 AFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREME-SYSQAGKQAEEVLKSVKTVV 162
+ +L L + MPF+I A + N + + +RE++ + ++AG+ E + ++TV
Sbjct: 285 MLSISPRLTLLSLLHMPFTIAAE-KVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVR 343
Query: 163 AFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDA 222
+FG E EV RYK LE RR L L VL + + G +
Sbjct: 344 SFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQ------ 397
Query: 223 NKPDDERTYIIGIVLS-ITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKID 281
D E T G +LS + + + + TL + ++ + GAA +FS +D+ P +
Sbjct: 398 QMQDGELTQ--GSLLSFMIYQESVGSYVQTLVYIYGDMLSNV-GAAEKVFSYMDRQPNLP 454
Query: 282 CLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
S +P + G + +DV F+YP+R D +LKG + ++PGE ALVG +G GKST+
Sbjct: 455 --SPGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV 512
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEAT 401
LLQ LY P G V LD + + +L S + VGQEPVLF G++ +NIA G
Sbjct: 513 AALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE 572
Query: 402 SEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 461
+ V A+ A+A +FI+ + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDE
Sbjct: 573 DDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDE 632
Query: 462 ATSALDPHSEK 472
ATSALD E+
Sbjct: 633 ATSALDVQCEQ 643
Score = 160 bits (389), Expect = 2e-38
Identities = 123/420 (29%), Positives = 200/420 (47%), Gaps = 12/420 (2%)
Query: 670 EIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTL 729
++G+F +E+ T G + +RLS DT + L ++L+ V + +S + +LTL
Sbjct: 237 DLGFF-QETKT-GELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTL 294
Query: 730 VSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFITR 789
+S +P + + + Q+ ++ ++A+ A + EAV ++TV+S G E + R
Sbjct: 295 LSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCR 354
Query: 790 FQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXX 849
+++AL ++ R L L + + L + G + G
Sbjct: 355 YKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMI 414
Query: 850 XX-MYGAYMLGQSLVYAPSFNSAKTCGA-RILSIINREPRIRTVDGLNDKQDWSASGNFS 907
G+Y+ Q+LVY + A ++ S ++R+P + + L + G
Sbjct: 415 YQESVGSYV--QTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPT---TLQGVVK 469
Query: 908 INDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIEL 967
DV F+YP R + +LKG+ + G+ ALVG +G GKSTV L+Q Y PT G + L
Sbjct: 470 FQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLL 529
Query: 968 DGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXH 1027
D I++ L Q+ V QEP+LF ++ NIAYG S + D+
Sbjct: 530 DEKPISQ-YEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCED--DKVMAAAQAAHAD 586
Query: 1028 NFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVT 1087
+FI + G T+ KQR+ IARAL+R PR+L+LDEATSALD E+A T
Sbjct: 587 DFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQAKT 646
>BX296564-5|CAI41937.1| 653|Homo sapiens transporter 2 ATP-binding
cassette sub-family B (MDR/TAP) protein.
Length = 653
Score = 218 bits (532), Expect = 1e-55
Identities = 144/431 (33%), Positives = 228/431 (52%), Gaps = 14/431 (3%)
Query: 44 IRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAVVSNLVGTSIICLCT 103
IR+ +++LRQD+ +F L S++S + + + V+ + +
Sbjct: 225 IREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGF 284
Query: 104 AFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREME-SYSQAGKQAEEVLKSVKTVV 162
+ +L L + MPF+I A + N + + +RE++ + ++AG+ E + ++TV
Sbjct: 285 MLSISPRLTLLSLLHMPFTIAAE-KVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVR 343
Query: 163 AFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDA 222
+FG E EV RYK LE RR L L VL + + G +
Sbjct: 344 SFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQ------ 397
Query: 223 NKPDDERTYIIGIVLS-ITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKID 281
D E T G +LS + + + + TL + ++ + GAA +FS +D+ P +
Sbjct: 398 QMQDGELTQ--GSLLSFMIYQESVGSYVQTLVYIYGDMLSNV-GAAEKVFSYMDRQPNLP 454
Query: 282 CLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
S +P + G + +DV F+YP+R D +LKG + ++PGE ALVG +G GKST+
Sbjct: 455 --SPGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV 512
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEAT 401
LLQ LY P G V LD + + +L S + VGQEPVLF G++ +NIA G
Sbjct: 513 AALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE 572
Query: 402 SEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 461
+ V A+ A+A +FI+ + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDE
Sbjct: 573 DDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDE 632
Query: 462 ATSALDPHSEK 472
ATSALD E+
Sbjct: 633 ATSALDVQCEQ 643
Score = 160 bits (389), Expect = 2e-38
Identities = 123/420 (29%), Positives = 200/420 (47%), Gaps = 12/420 (2%)
Query: 670 EIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTL 729
++G+F +E+ T G + +RLS DT + L ++L+ V + +S + +LTL
Sbjct: 237 DLGFF-QETKT-GELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTL 294
Query: 730 VSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFITR 789
+S +P + + + Q+ ++ ++A+ A + EAV ++TV+S G E + R
Sbjct: 295 LSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCR 354
Query: 790 FQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXX 849
+++AL ++ R L L + + L + G + G
Sbjct: 355 YKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMI 414
Query: 850 XX-MYGAYMLGQSLVYAPSFNSAKTCGA-RILSIINREPRIRTVDGLNDKQDWSASGNFS 907
G+Y+ Q+LVY + A ++ S ++R+P + + L + G
Sbjct: 415 YQESVGSYV--QTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPT---TLQGVVK 469
Query: 908 INDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIEL 967
DV F+YP R + +LKG+ + G+ ALVG +G GKSTV L+Q Y PT G + L
Sbjct: 470 FQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLL 529
Query: 968 DGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXH 1027
D I++ L Q+ V QEP+LF ++ NIAYG S + D+
Sbjct: 530 DEKPISQ-YEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCED--DKVMAAAQAAHAD 586
Query: 1028 NFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVT 1087
+FI + G T+ KQR+ IARAL+R PR+L+LDEATSALD E+A T
Sbjct: 587 DFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQAKT 646
>AL935043-1|CAI18621.1| 653|Homo sapiens transporter 2, ATP-binding
cassette, sub-family Budogene) protein.
Length = 653
Score = 218 bits (532), Expect = 1e-55
Identities = 144/431 (33%), Positives = 228/431 (52%), Gaps = 14/431 (3%)
Query: 44 IRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAVVSNLVGTSIICLCT 103
IR+ +++LRQD+ +F L S++S + + + V+ + +
Sbjct: 225 IREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGF 284
Query: 104 AFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREME-SYSQAGKQAEEVLKSVKTVV 162
+ +L L + MPF+I A + N + + +RE++ + ++AG+ E + ++TV
Sbjct: 285 MLSISPRLTLLSLLHMPFTIAAE-KVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVR 343
Query: 163 AFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDA 222
+FG E EV RYK LE RR L L VL + + G +
Sbjct: 344 SFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQ------ 397
Query: 223 NKPDDERTYIIGIVLS-ITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKID 281
D E T G +LS + + + + TL + ++ + GAA +FS +D+ P +
Sbjct: 398 QMQDGELTQ--GSLLSFMIYQESVGSYVQTLVYIYGDMLSNV-GAAEKVFSYMDRQPNLP 454
Query: 282 CLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
S +P + G + +DV F+YP+R D +LKG + ++PGE ALVG +G GKST+
Sbjct: 455 --SPGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV 512
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEAT 401
LLQ LY P G V LD + + +L S + VGQEPVLF G++ +NIA G
Sbjct: 513 AALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE 572
Query: 402 SEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 461
+ V A+ A+A +FI+ + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDE
Sbjct: 573 DDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDE 632
Query: 462 ATSALDPHSEK 472
ATSALD E+
Sbjct: 633 ATSALDVQCEQ 643
Score = 160 bits (389), Expect = 2e-38
Identities = 123/420 (29%), Positives = 200/420 (47%), Gaps = 12/420 (2%)
Query: 670 EIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTL 729
++G+F +E+ T G + +RLS DT + L ++L+ V + +S + +LTL
Sbjct: 237 DLGFF-QETKT-GELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTL 294
Query: 730 VSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFITR 789
+S +P + + + Q+ ++ ++A+ A + EAV ++TV+S G E + R
Sbjct: 295 LSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCR 354
Query: 790 FQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXX 849
+++AL ++ R L L + + L + G + G
Sbjct: 355 YKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMI 414
Query: 850 XX-MYGAYMLGQSLVYAPSFNSAKTCGA-RILSIINREPRIRTVDGLNDKQDWSASGNFS 907
G+Y+ Q+LVY + A ++ S ++R+P + + L + G
Sbjct: 415 YQESVGSYV--QTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPT---TLQGVVK 469
Query: 908 INDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIEL 967
DV F+YP R + +LKG+ + G+ ALVG +G GKSTV L+Q Y PT G + L
Sbjct: 470 FQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLL 529
Query: 968 DGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXH 1027
D I++ L Q+ V QEP+LF ++ NIAYG S + D+
Sbjct: 530 DEKPISQ-YEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCED--DKVMAAAQAAHAD 586
Query: 1028 NFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVT 1087
+FI + G T+ KQR+ IARAL+R PR+L+LDEATSALD E+A T
Sbjct: 587 DFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQAKT 646
>AL671681-7|CAI17710.1| 653|Homo sapiens transporter 2, ATP-binding
cassette, sub-family Bpha protein.
Length = 653
Score = 218 bits (532), Expect = 1e-55
Identities = 144/431 (33%), Positives = 228/431 (52%), Gaps = 14/431 (3%)
Query: 44 IRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAVVSNLVGTSIICLCT 103
IR+ +++LRQD+ +F L S++S + + + V+ + +
Sbjct: 225 IREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGF 284
Query: 104 AFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREME-SYSQAGKQAEEVLKSVKTVV 162
+ +L L + MPF+I A + N + + +RE++ + ++AG+ E + ++TV
Sbjct: 285 MLSISPRLTLLSLLHMPFTIAAE-KVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVR 343
Query: 163 AFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDA 222
+FG E EV RYK LE RR L L VL + + G +
Sbjct: 344 SFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQ------ 397
Query: 223 NKPDDERTYIIGIVLS-ITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKID 281
D E T G +LS + + + + TL + ++ + GAA +FS +D+ P +
Sbjct: 398 QMQDGELTQ--GSLLSFMIYQESVGSYVQTLVYIYGDMLSNV-GAAEKVFSYMDRQPNLP 454
Query: 282 CLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
S +P + G + +DV F+YP+R D +LKG + ++PGE ALVG +G GKST+
Sbjct: 455 --SPGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV 512
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEAT 401
LLQ LY P G V LD + + +L S + VGQEPVLF G++ +NIA G
Sbjct: 513 AALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE 572
Query: 402 SEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 461
+ V A+ A+A +FI+ + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDE
Sbjct: 573 DDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDE 632
Query: 462 ATSALDPHSEK 472
ATSALD E+
Sbjct: 633 ATSALDVQCEQ 643
Score = 160 bits (389), Expect = 2e-38
Identities = 123/420 (29%), Positives = 200/420 (47%), Gaps = 12/420 (2%)
Query: 670 EIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTL 729
++G+F +E+ T G + +RLS DT + L ++L+ V + +S + +LTL
Sbjct: 237 DLGFF-QETKT-GELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTL 294
Query: 730 VSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFITR 789
+S +P + + + Q+ ++ ++A+ A + EAV ++TV+S G E + R
Sbjct: 295 LSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCR 354
Query: 790 FQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXX 849
+++AL ++ R L L + + L + G + G
Sbjct: 355 YKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMI 414
Query: 850 XX-MYGAYMLGQSLVYAPSFNSAKTCGA-RILSIINREPRIRTVDGLNDKQDWSASGNFS 907
G+Y+ Q+LVY + A ++ S ++R+P + + L + G
Sbjct: 415 YQESVGSYV--QTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPT---TLQGVVK 469
Query: 908 INDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIEL 967
DV F+YP R + +LKG+ + G+ ALVG +G GKSTV L+Q Y PT G + L
Sbjct: 470 FQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLL 529
Query: 968 DGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXH 1027
D I++ L Q+ V QEP+LF ++ NIAYG S + D+
Sbjct: 530 DEKPISQ-YEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCED--DKVMAAAQAAHAD 586
Query: 1028 NFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVT 1087
+FI + G T+ KQR+ IARAL+R PR+L+LDEATSALD E+A T
Sbjct: 587 DFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQAKT 646
>AL669918-3|CAI18136.1| 653|Homo sapiens transporter 2, ATP-binding
cassette, sub-family Bunit 11 protein.
Length = 653
Score = 218 bits (532), Expect = 1e-55
Identities = 144/431 (33%), Positives = 228/431 (52%), Gaps = 14/431 (3%)
Query: 44 IRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAVVSNLVGTSIICLCT 103
IR+ +++LRQD+ +F L S++S + + + V+ + +
Sbjct: 225 IREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGF 284
Query: 104 AFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREME-SYSQAGKQAEEVLKSVKTVV 162
+ +L L + MPF+I A + N + + +RE++ + ++AG+ E + ++TV
Sbjct: 285 MLSISPRLTLLSLLHMPFTIAAE-KVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVR 343
Query: 163 AFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDA 222
+FG E EV RYK LE RR L L VL + + G +
Sbjct: 344 SFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQ------ 397
Query: 223 NKPDDERTYIIGIVLS-ITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKID 281
D E T G +LS + + + + TL + ++ + GAA +FS +D+ P +
Sbjct: 398 QMQDGELTQ--GSLLSFMIYQESVGSYVQTLVYIYGDMLSNV-GAAEKVFSYMDRQPNLP 454
Query: 282 CLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
S +P + G + +DV F+YP+R D +LKG + ++PGE ALVG +G GKST+
Sbjct: 455 --SPGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV 512
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEAT 401
LLQ LY P G V LD + + +L S + VGQEPVLF G++ +NIA G
Sbjct: 513 AALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE 572
Query: 402 SEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 461
+ V A+ A+A +FI+ + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDE
Sbjct: 573 DDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDE 632
Query: 462 ATSALDPHSEK 472
ATSALD E+
Sbjct: 633 ATSALDVQCEQ 643
Score = 160 bits (389), Expect = 2e-38
Identities = 123/420 (29%), Positives = 200/420 (47%), Gaps = 12/420 (2%)
Query: 670 EIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTL 729
++G+F +E+ T G + +RLS DT + L ++L+ V + +S + +LTL
Sbjct: 237 DLGFF-QETKT-GELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTL 294
Query: 730 VSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFITR 789
+S +P + + + Q+ ++ ++A+ A + EAV ++TV+S G E + R
Sbjct: 295 LSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCR 354
Query: 790 FQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXX 849
+++AL ++ R L L + + L + G + G
Sbjct: 355 YKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMI 414
Query: 850 XX-MYGAYMLGQSLVYAPSFNSAKTCGA-RILSIINREPRIRTVDGLNDKQDWSASGNFS 907
G+Y+ Q+LVY + A ++ S ++R+P + + L + G
Sbjct: 415 YQESVGSYV--QTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPT---TLQGVVK 469
Query: 908 INDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIEL 967
DV F+YP R + +LKG+ + G+ ALVG +G GKSTV L+Q Y PT G + L
Sbjct: 470 FQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLL 529
Query: 968 DGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXH 1027
D I++ L Q+ V QEP+LF ++ NIAYG S + D+
Sbjct: 530 DEKPISQ-YEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCED--DKVMAAAQAAHAD 586
Query: 1028 NFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVT 1087
+FI + G T+ KQR+ IARAL+R PR+L+LDEATSALD E+A T
Sbjct: 587 DFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQAKT 646
>AF078671-1|AAD31384.1| 653|Homo sapiens transporter 2 isoform
protein.
Length = 653
Score = 218 bits (532), Expect = 1e-55
Identities = 144/431 (33%), Positives = 228/431 (52%), Gaps = 14/431 (3%)
Query: 44 IRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAVVSNLVGTSIICLCT 103
IR+ +++LRQD+ +F L S++S + + + V+ + +
Sbjct: 225 IREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGF 284
Query: 104 AFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREME-SYSQAGKQAEEVLKSVKTVV 162
+ +L L + MPF+I A + N + + +RE++ + ++AG+ E + ++TV
Sbjct: 285 MLSISPRLTLLSLLHMPFTIAAE-KVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVR 343
Query: 163 AFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDA 222
+FG E EV RYK LE RR L L VL + + G +
Sbjct: 344 SFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQ------ 397
Query: 223 NKPDDERTYIIGIVLS-ITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKID 281
D E T G +LS + + + + TL + ++ + GAA +FS +D+ P +
Sbjct: 398 QMQDGELTQ--GSLLSFMIYQESVGSYVQTLVYIYGDMLSNV-GAAEKVFSYMDRQPNLP 454
Query: 282 CLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
S +P + G + +DV F+YP+R D +LKG + ++PGE ALVG +G GKST+
Sbjct: 455 --SPGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV 512
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEAT 401
LLQ LY P G V LD + + +L S + VGQEPVLF G++ +NIA G
Sbjct: 513 AALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE 572
Query: 402 SEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 461
+ V A+ A+A +FI+ + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDE
Sbjct: 573 DDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDE 632
Query: 462 ATSALDPHSEK 472
ATSALD E+
Sbjct: 633 ATSALDVQCEQ 643
Score = 160 bits (389), Expect = 2e-38
Identities = 123/420 (29%), Positives = 200/420 (47%), Gaps = 12/420 (2%)
Query: 670 EIGYFDRESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTL 729
++G+F +E+ T G + +RLS DT + L ++L+ V + +S + +LTL
Sbjct: 237 DLGFF-QETKT-GELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTL 294
Query: 730 VSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFITR 789
+S +P + + + Q+ ++ ++A+ A + EAV ++TV+S G E + R
Sbjct: 295 LSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCR 354
Query: 790 FQDALIDACAAVVKKSRWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXX 849
+++AL ++ R L L + + L + G + G
Sbjct: 355 YKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMI 414
Query: 850 XX-MYGAYMLGQSLVYAPSFNSAKTCGA-RILSIINREPRIRTVDGLNDKQDWSASGNFS 907
G+Y+ Q+LVY + A ++ S ++R+P + + L + G
Sbjct: 415 YQESVGSYV--QTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPT---TLQGVVK 469
Query: 908 INDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIEL 967
DV F+YP R + +LKG+ + G+ ALVG +G GKSTV L+Q Y PT G + L
Sbjct: 470 FQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLL 529
Query: 968 DGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXH 1027
D I++ L Q+ V QEP+LF ++ NIAYG S + D+
Sbjct: 530 DEKPISQ-YEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCED--DKVMAAAQAAHAD 586
Query: 1028 NFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVT 1087
+FI + G T+ KQR+ IARAL+R PR+L+LDEATSALD E+A T
Sbjct: 587 DFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQAKT 646
>U18237-1|AAA84438.1| 229|Homo sapiens ATP-binding cassette protein
protein.
Length = 229
Score = 211 bits (515), Expect = 1e-53
Identities = 116/221 (52%), Positives = 144/221 (65%), Gaps = 6/221 (2%)
Query: 316 KGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIG-WLRSS 374
K FSL I G ALVG SG GKST+L LL RLYDP G++ LDG + + WLRS
Sbjct: 2 KDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDNPSAKPSVWLRSK 61
Query: 375 LGVVGQEPVLFRGTIYDNIAIGYPE---ATSEDVYRVAEMAYAHEFIKNLPNGYETVIGE 431
+G V QEP+LF +I +NIA G + T+E++ RVAE+A A P + TV+GE
Sbjct: 62 IGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAS-PEFPPRFNTVVGE 120
Query: 432 RGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVS 491
+G LSGGQKQRIAIAR+LL+ P +LLLDEATSALD +E VQ ALDR GRT L ++
Sbjct: 121 KGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIA 180
Query: 492 HRLSTIVNCHRIICMDQGTIIEQGTHVELM-KAKGFYHKLV 531
H LSTI N + + +DQG I E G H EL+ K G Y KL+
Sbjct: 181 HSLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLM 221
Score = 179 bits (436), Expect = 5e-44
Identities = 103/227 (45%), Positives = 134/227 (59%), Gaps = 7/227 (3%)
Query: 925 KGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQ 984
K L + +G ALVG SG GKSTVL L+ R YDP +G I LDG D + LR +
Sbjct: 2 KDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDNPSAKPSVWLRSK 61
Query: 985 LGVVQQEPILFDRTLAENIAYG-DNSRKPTMDEXXXXXXXXXXHNFIVS--LPKGYETNX 1041
+G V QEPILF ++AENIAYG D+ T +E N + S P + T
Sbjct: 62 IGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVA---NAVASPEFPPRFNTVV 118
Query: 1042 XXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEALDHAAKGRTCIT 1101
KQR+ IARAL+++P++LLLDEATSALDA +E V EALD GRT +
Sbjct: 119 GEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLV 178
Query: 1102 IAHRLTTIKDADIICVLDKGKIVEKGNHAELIGL-KGHYWQLSKQQN 1147
IAH L+TIK+A+++ VLD+GKI E G H EL+ G Y +L +Q+
Sbjct: 179 IAHSLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLMNKQS 225
>AB112583-1|BAC98410.1| 681|Homo sapiens TAP-Like isoform 12C
protein.
Length = 681
Score = 202 bits (494), Expect = 4e-51
Identities = 132/432 (30%), Positives = 219/432 (50%), Gaps = 18/432 (4%)
Query: 44 IRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAV-VSNLVGTSIICLC 102
+R +++ Q+ ++FD + +L S+++ + + + + + + V + N V + + +
Sbjct: 261 LRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVF 320
Query: 103 TAFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTVV 162
F L W+L+L P +M S Y + S + ++A AEE + ++KTV
Sbjct: 321 M-FSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVR 379
Query: 163 AFGGENIEVQRYKSLLEPAEISGSRRG---LFTGLGNGFNWVLTYSLNTIGFMYGTRLII 219
+F E E + Y L+ + ++ G+G +L ++ + YG L+I
Sbjct: 380 SFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLT-LLVVQVSIL--YYGGHLVI 436
Query: 220 EDANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPK 279
+ +II F + +S+ + GAA +F +D+ P
Sbjct: 437 SGQMTSGNLIAFII-----YEFVLGDCMESVGSVYSGL---MQGVGAAEKVFEFIDRQPT 488
Query: 280 IDCLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKS 339
+ + + +P + G + E+V F+Y +R ++L+ S + PG+ ALVG SG GKS
Sbjct: 489 M--VHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKS 546
Query: 340 TILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPE 399
+ + +L+ Y G V LDG+ + + +L + +V QEPVLF +I DNI+ G P
Sbjct: 547 SCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPT 606
Query: 400 ATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLL 459
E V A+ A AH FI L +GY T GE+GA LSGGQKQR+A+AR+L+R P VL+L
Sbjct: 607 VPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLIL 666
Query: 460 DEATSALDPHSE 471
DEATSALD SE
Sbjct: 667 DEATSALDAESE 678
Score = 159 bits (386), Expect = 5e-38
Identities = 134/461 (29%), Positives = 207/461 (44%), Gaps = 37/461 (8%)
Query: 643 LTVGS-IAAFIQGACFP-VFA---------LLLGYTSGEIGYFDRESNTVGAVCARLSGD 691
L +GS AA I+G F +FA L S E +FD N G + +RL+ D
Sbjct: 235 LAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDE--NRTGDLISRLTSD 292
Query: 692 TAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGSIWLEGIMSQK 751
T V I + L+ VT + S +W+L+LV+ P+++ + G ++
Sbjct: 293 TTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKR 352
Query: 752 SQQDEREAMESATAIATEAVVSIKTVQSLGIES----LFITRFQDA--LIDACAAVVKKS 805
++ + A+ A+ A E + ++KTV+S E +++ + Q L AA
Sbjct: 353 LSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYY 412
Query: 806 RWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXXXX-MYGAYMLGQSLVY 864
W GL + L+ S + YG LV G + G M VY
Sbjct: 413 VWGS---GLTL---LVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVY 466
Query: 865 APSFNSAKTCGARILSIINREPRIRTVDGLNDKQDWSASGNFSINDVEFSYPTRAHQMIL 924
+ ++ I+R+P + L G +V F+Y TR H +L
Sbjct: 467 SGLMQGVGAA-EKVFEFIDRQPTMVHDGSLAPDH---LEGRVDFENVTFTYRTRPHTQVL 522
Query: 925 KGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQ 984
+ + + GK ALVG SG GKS+ + +++ FY G + LDG I+ + L +
Sbjct: 523 QNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPIS-AYDHKYLHRV 581
Query: 985 LGVVQQEPILFDRTLAENIAYGDNSRKPTM--DEXXXXXXXXXXHNFIVSLPKGYETNXX 1042
+ +V QEP+LF R++ +NI+YG PT+ + H FI+ L GY T
Sbjct: 582 ISLVSQEPVLFARSITDNISYG----LPTVPFEMVVEAAQKANAHGFIMELQDGYSTETG 637
Query: 1043 XXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSE 1083
KQRV +ARAL+R+P +L+LDEATSALDA SE
Sbjct: 638 EKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESE 678
>AB112582-1|BAC98409.1| 683|Homo sapiens TAP-Like isoform 12B
protein.
Length = 683
Score = 202 bits (494), Expect = 4e-51
Identities = 132/432 (30%), Positives = 219/432 (50%), Gaps = 18/432 (4%)
Query: 44 IRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAV-VSNLVGTSIICLC 102
+R +++ Q+ ++FD + +L S+++ + + + + + + V + N V + + +
Sbjct: 261 LRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVF 320
Query: 103 TAFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTVV 162
F L W+L+L P +M S Y + S + ++A AEE + ++KTV
Sbjct: 321 M-FSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVR 379
Query: 163 AFGGENIEVQRYKSLLEPAEISGSRRG---LFTGLGNGFNWVLTYSLNTIGFMYGTRLII 219
+F E E + Y L+ + ++ G+G +L ++ + YG L+I
Sbjct: 380 SFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLT-LLVVQVSIL--YYGGHLVI 436
Query: 220 EDANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPK 279
+ +II F + +S+ + GAA +F +D+ P
Sbjct: 437 SGQMTSGNLIAFII-----YEFVLGDCMESVGSVYSGL---MQGVGAAEKVFEFIDRQPT 488
Query: 280 IDCLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKS 339
+ + + +P + G + E+V F+Y +R ++L+ S + PG+ ALVG SG GKS
Sbjct: 489 M--VHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKS 546
Query: 340 TILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPE 399
+ + +L+ Y G V LDG+ + + +L + +V QEPVLF +I DNI+ G P
Sbjct: 547 SCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPT 606
Query: 400 ATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLL 459
E V A+ A AH FI L +GY T GE+GA LSGGQKQR+A+AR+L+R P VL+L
Sbjct: 607 VPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLIL 666
Query: 460 DEATSALDPHSE 471
DEATSALD SE
Sbjct: 667 DEATSALDAESE 678
Score = 159 bits (386), Expect = 5e-38
Identities = 134/461 (29%), Positives = 207/461 (44%), Gaps = 37/461 (8%)
Query: 643 LTVGS-IAAFIQGACFP-VFA---------LLLGYTSGEIGYFDRESNTVGAVCARLSGD 691
L +GS AA I+G F +FA L S E +FD N G + +RL+ D
Sbjct: 235 LAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDE--NRTGDLISRLTSD 292
Query: 692 TAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGSIWLEGIMSQK 751
T V I + L+ VT + S +W+L+LV+ P+++ + G ++
Sbjct: 293 TTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKR 352
Query: 752 SQQDEREAMESATAIATEAVVSIKTVQSLGIES----LFITRFQDA--LIDACAAVVKKS 805
++ + A+ A+ A E + ++KTV+S E +++ + Q L AA
Sbjct: 353 LSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYY 412
Query: 806 RWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXXXX-MYGAYMLGQSLVY 864
W GL + L+ S + YG LV G + G M VY
Sbjct: 413 VWGS---GLTL---LVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVY 466
Query: 865 APSFNSAKTCGARILSIINREPRIRTVDGLNDKQDWSASGNFSINDVEFSYPTRAHQMIL 924
+ ++ I+R+P + L G +V F+Y TR H +L
Sbjct: 467 SGLMQGVGAA-EKVFEFIDRQPTMVHDGSLAPDH---LEGRVDFENVTFTYRTRPHTQVL 522
Query: 925 KGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQ 984
+ + + GK ALVG SG GKS+ + +++ FY G + LDG I+ + L +
Sbjct: 523 QNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPIS-AYDHKYLHRV 581
Query: 985 LGVVQQEPILFDRTLAENIAYGDNSRKPTM--DEXXXXXXXXXXHNFIVSLPKGYETNXX 1042
+ +V QEP+LF R++ +NI+YG PT+ + H FI+ L GY T
Sbjct: 582 ISLVSQEPVLFARSITDNISYG----LPTVPFEMVVEAAQKANAHGFIMELQDGYSTETG 637
Query: 1043 XXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSE 1083
KQRV +ARAL+R+P +L+LDEATSALDA SE
Sbjct: 638 EKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESE 678
>Y17151-1|CAA76658.2| 1527|Homo sapiens multidrug resistance protein 3
(ABCC3) protein.
Length = 1527
Score = 161 bits (390), Expect = 2e-38
Identities = 78/234 (33%), Positives = 142/234 (60%), Gaps = 2/234 (0%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
GE+ + Y D+ +L+ SLH+ GE V +VG +G GKS++ L R+ + +G
Sbjct: 1287 GEVEFRNYSVRYRPGLDL-VLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKG 1345
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+++DG N+ + + LRS L ++ Q+P+LF GT+ N+ + + ED++ E+++
Sbjct: 1346 EIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLD-PFGSYSEEDIWWALELSHL 1404
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
H F+ + P G + E G +LS GQ+Q + +AR+LLR+ +L+LDEAT+A+D ++ +
Sbjct: 1405 HTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLI 1464
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYH 528
QA + T LT++HRL+TI++ R++ +D+G + E + L+ A+G ++
Sbjct: 1465 QATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIFY 1518
Score = 139 bits (336), Expect = 6e-32
Identities = 79/255 (30%), Positives = 129/255 (50%), Gaps = 7/255 (2%)
Query: 891 VDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTV 950
V+G + W G + Y ++L+ + LHV G+ V +VG +G GKS++
Sbjct: 1274 VEGSRPPEGWPPRGEVEFRNYSVRYRPGL-DLVLRDLSLHVHGGEKVGIVGRTGAGKSSM 1332
Query: 951 LQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENI-AYGDNS 1009
+ R + G I +DG+++ + L+ LR QL ++ Q+PILF TL N+ +G S
Sbjct: 1333 TLCLFRILEAAKGEIRIDGLNVA-DIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYS 1391
Query: 1010 RKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLL 1069
++ H F+ S P G + +Q VC+ARAL+R R+L
Sbjct: 1392 E----EDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRIL 1447
Query: 1070 LLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNH 1129
+LDEAT+A+D ++ + + T +TIAHRL TI D + VLDKG + E +
Sbjct: 1448 VLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSP 1507
Query: 1130 AELIGLKGHYWQLSK 1144
A LI +G ++ +++
Sbjct: 1508 ANLIAARGIFYGMAR 1522
Score = 91.1 bits (216), Expect = 2e-17
Identities = 67/247 (27%), Positives = 119/247 (48%), Gaps = 22/247 (8%)
Query: 315 LKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSS 374
L + + G VA+VG GCGKS+++ L + +G V + G S
Sbjct: 644 LHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKG-------------S 690
Query: 375 LGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYR-VAEMAYAHEFIKNLPNGYETVIGERG 433
+ V Q+ + T+ +N+ G +A + Y+ E ++ LP G +T IGE+G
Sbjct: 691 VAYVPQQAWIQNCTLQENVLFG--KALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKG 748
Query: 434 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV---QAALDRASVGRTTLTV 490
+LSGGQ+QR+++AR++ + + LLD+ SA+D H K + + G+T + V
Sbjct: 749 INLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLV 808
Query: 491 SHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTS---GKETKEPEEIGTVL 547
+H +S + II + G + E G + L++ G + + + ++ E+ T L
Sbjct: 809 THGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTAL 868
Query: 548 EEQETKQ 554
E E K+
Sbjct: 869 EGAEDKE 875
Score = 66.1 bits (154), Expect = 7e-10
Identities = 50/219 (22%), Positives = 93/219 (42%), Gaps = 20/219 (9%)
Query: 924 LKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRK 983
L +D+ V G VA+VG GCGKS+++ + + G + + G
Sbjct: 644 LHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKG-------------- 689
Query: 984 QLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXX 1043
+ V Q+ + + TL EN+ +G + + LP G +T
Sbjct: 690 SVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLAD---LEMLPGGDQTEIGE 746
Query: 1044 XXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEAL---DHAAKGRTCI 1100
+QRV +ARA+ + LLD+ SA+D++ + + + + + G+T +
Sbjct: 747 KGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRV 806
Query: 1101 TIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHY 1139
+ H ++ + D I VL G++ E G + L+ G +
Sbjct: 807 LVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSF 845
>AF154001-1|AAD38185.1| 285|Homo sapiens MRP3s1 protein protein.
Length = 285
Score = 161 bits (390), Expect = 2e-38
Identities = 78/234 (33%), Positives = 142/234 (60%), Gaps = 2/234 (0%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
GE+ + Y D+ +L+ SLH+ GE V +VG +G GKS++ L R+ + +G
Sbjct: 45 GEVEFRNYSVRYRPGLDL-VLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKG 103
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+++DG N+ + + LRS L ++ Q+P+LF GT+ N+ + + ED++ E+++
Sbjct: 104 EIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLD-PFGSYSEEDIWWALELSHL 162
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
H F+ + P G + E G +LS GQ+Q + +AR+LLR+ +L+LDEAT+A+D ++ +
Sbjct: 163 HTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLI 222
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYH 528
QA + T LT++HRL+TI++ R++ +D+G + E + L+ A+G ++
Sbjct: 223 QATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIFY 276
Score = 139 bits (336), Expect = 6e-32
Identities = 79/255 (30%), Positives = 129/255 (50%), Gaps = 7/255 (2%)
Query: 891 VDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTV 950
V+G + W G + Y ++L+ + LHV G+ V +VG +G GKS++
Sbjct: 32 VEGSRPPEGWPPRGEVEFRNYSVRYRPGL-DLVLRDLSLHVHGGEKVGIVGRTGAGKSSM 90
Query: 951 LQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENI-AYGDNS 1009
+ R + G I +DG+++ + L+ LR QL ++ Q+PILF TL N+ +G S
Sbjct: 91 TLCLFRILEAAKGEIRIDGLNVA-DIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYS 149
Query: 1010 RKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLL 1069
++ H F+ S P G + +Q VC+ARAL+R R+L
Sbjct: 150 E----EDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRIL 205
Query: 1070 LLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNH 1129
+LDEAT+A+D ++ + + T +TIAHRL TI D + VLDKG + E +
Sbjct: 206 VLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSP 265
Query: 1130 AELIGLKGHYWQLSK 1144
A LI +G ++ +++
Sbjct: 266 ANLIAARGIFYGMAR 280
>AF104943-1|AAD04170.1| 1527|Homo sapiens ABC transporter MOAT-D
protein.
Length = 1527
Score = 161 bits (390), Expect = 2e-38
Identities = 78/234 (33%), Positives = 142/234 (60%), Gaps = 2/234 (0%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
GE+ + Y D+ +L+ SLH+ GE V +VG +G GKS++ L R+ + +G
Sbjct: 1287 GEVEFRNYSVRYRPGLDL-VLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKG 1345
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+++DG N+ + + LRS L ++ Q+P+LF GT+ N+ + + ED++ E+++
Sbjct: 1346 EIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLD-PFGSYSEEDIWWALELSHL 1404
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
H F+ + P G + E G +LS GQ+Q + +AR+LLR+ +L+LDEAT+A+D ++ +
Sbjct: 1405 HTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLI 1464
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYH 528
QA + T LT++HRL+TI++ R++ +D+G + E + L+ A+G ++
Sbjct: 1465 QATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIFY 1518
Score = 139 bits (336), Expect = 6e-32
Identities = 79/255 (30%), Positives = 129/255 (50%), Gaps = 7/255 (2%)
Query: 891 VDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTV 950
V+G + W G + Y ++L+ + LHV G+ V +VG +G GKS++
Sbjct: 1274 VEGSRPPEGWPPRGEVEFRNYSVRYRPGL-DLVLRDLSLHVHGGEKVGIVGRTGAGKSSM 1332
Query: 951 LQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENI-AYGDNS 1009
+ R + G I +DG+++ + L+ LR QL ++ Q+PILF TL N+ +G S
Sbjct: 1333 TLCLFRILEAAKGEIRIDGLNVA-DIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYS 1391
Query: 1010 RKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLL 1069
++ H F+ S P G + +Q VC+ARAL+R R+L
Sbjct: 1392 E----EDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRIL 1447
Query: 1070 LLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNH 1129
+LDEAT+A+D ++ + + T +TIAHRL TI D + VLDKG + E +
Sbjct: 1448 VLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSP 1507
Query: 1130 AELIGLKGHYWQLSK 1144
A LI +G ++ +++
Sbjct: 1508 ANLIAARGIFYGMAR 1522
Score = 91.1 bits (216), Expect = 2e-17
Identities = 67/247 (27%), Positives = 119/247 (48%), Gaps = 22/247 (8%)
Query: 315 LKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSS 374
L + + G VA+VG GCGKS+++ L + +G V + G S
Sbjct: 644 LHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKG-------------S 690
Query: 375 LGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYR-VAEMAYAHEFIKNLPNGYETVIGERG 433
+ V Q+ + T+ +N+ G +A + Y+ E ++ LP G +T IGE+G
Sbjct: 691 VAYVPQQAWIQNCTLQENVLFG--KALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKG 748
Query: 434 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV---QAALDRASVGRTTLTV 490
+LSGGQ+QR+++AR++ + + LLD+ SA+D H K + + G+T + V
Sbjct: 749 INLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLV 808
Query: 491 SHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTS---GKETKEPEEIGTVL 547
+H +S + II + G + E G + L++ G + + + ++ E+ T L
Sbjct: 809 THGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTAL 868
Query: 548 EEQETKQ 554
E E K+
Sbjct: 869 EGAEDKE 875
Score = 66.1 bits (154), Expect = 7e-10
Identities = 50/219 (22%), Positives = 93/219 (42%), Gaps = 20/219 (9%)
Query: 924 LKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRK 983
L +D+ V G VA+VG GCGKS+++ + + G + + G
Sbjct: 644 LHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKG-------------- 689
Query: 984 QLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXX 1043
+ V Q+ + + TL EN+ +G + + LP G +T
Sbjct: 690 SVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLAD---LEMLPGGDQTEIGE 746
Query: 1044 XXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEAL---DHAAKGRTCI 1100
+QRV +ARA+ + LLD+ SA+D++ + + + + + G+T +
Sbjct: 747 KGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRV 806
Query: 1101 TIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHY 1139
+ H ++ + D I VL G++ E G + L+ G +
Sbjct: 807 LVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSF 845
>AF085690-1|AAD02845.1| 1527|Homo sapiens multidrug
resistance-associated protein 3 protein.
Length = 1527
Score = 161 bits (390), Expect = 2e-38
Identities = 78/234 (33%), Positives = 142/234 (60%), Gaps = 2/234 (0%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
GE+ + Y D+ +L+ SLH+ GE V +VG +G GKS++ L R+ + +G
Sbjct: 1287 GEVEFRNYSVRYRPGLDL-VLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKG 1345
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+++DG N+ + + LRS L ++ Q+P+LF GT+ N+ + + ED++ E+++
Sbjct: 1346 EIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLD-PFGSYSEEDIWWALELSHL 1404
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
H F+ + P G + E G +LS GQ+Q + +AR+LLR+ +L+LDEAT+A+D ++ +
Sbjct: 1405 HTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLI 1464
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYH 528
QA + T LT++HRL+TI++ R++ +D+G + E + L+ A+G ++
Sbjct: 1465 QATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIFY 1518
Score = 139 bits (336), Expect = 6e-32
Identities = 79/255 (30%), Positives = 129/255 (50%), Gaps = 7/255 (2%)
Query: 891 VDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTV 950
V+G + W G + Y ++L+ + LHV G+ V +VG +G GKS++
Sbjct: 1274 VEGSRPPEGWPPRGEVEFRNYSVRYRPGL-DLVLRDLSLHVHGGEKVGIVGRTGAGKSSM 1332
Query: 951 LQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENI-AYGDNS 1009
+ R + G I +DG+++ + L+ LR QL ++ Q+PILF TL N+ +G S
Sbjct: 1333 TLCLFRILEAAKGEIRIDGLNVA-DIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYS 1391
Query: 1010 RKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLL 1069
++ H F+ S P G + +Q VC+ARAL+R R+L
Sbjct: 1392 E----EDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRIL 1447
Query: 1070 LLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNH 1129
+LDEAT+A+D ++ + + T +TIAHRL TI D + VLDKG + E +
Sbjct: 1448 VLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSP 1507
Query: 1130 AELIGLKGHYWQLSK 1144
A LI +G ++ +++
Sbjct: 1508 ANLIAARGIFYGMAR 1522
Score = 91.1 bits (216), Expect = 2e-17
Identities = 67/247 (27%), Positives = 119/247 (48%), Gaps = 22/247 (8%)
Query: 315 LKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSS 374
L + + G VA+VG GCGKS+++ L + +G V + G S
Sbjct: 644 LHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKG-------------S 690
Query: 375 LGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYR-VAEMAYAHEFIKNLPNGYETVIGERG 433
+ V Q+ + T+ +N+ G +A + Y+ E ++ LP G +T IGE+G
Sbjct: 691 VAYVPQQAWIQNCTLQENVLFG--KALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKG 748
Query: 434 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV---QAALDRASVGRTTLTV 490
+LSGGQ+QR+++AR++ + + LLD+ SA+D H K + + G+T + V
Sbjct: 749 INLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLV 808
Query: 491 SHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTS---GKETKEPEEIGTVL 547
+H +S + II + G + E G + L++ G + + + ++ E+ T L
Sbjct: 809 THGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTAL 868
Query: 548 EEQETKQ 554
E E K+
Sbjct: 869 EGAEDKE 875
Score = 66.1 bits (154), Expect = 7e-10
Identities = 50/219 (22%), Positives = 93/219 (42%), Gaps = 20/219 (9%)
Query: 924 LKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRK 983
L +D+ V G VA+VG GCGKS+++ + + G + + G
Sbjct: 644 LHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKG-------------- 689
Query: 984 QLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXX 1043
+ V Q+ + + TL EN+ +G + + LP G +T
Sbjct: 690 SVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLAD---LEMLPGGDQTEIGE 746
Query: 1044 XXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEAL---DHAAKGRTCI 1100
+QRV +ARA+ + LLD+ SA+D++ + + + + + G+T +
Sbjct: 747 KGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRV 806
Query: 1101 TIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHY 1139
+ H ++ + D I VL G++ E G + L+ G +
Sbjct: 807 LVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSF 845
>AF009670-1|AAD01430.1| 1528|Homo sapiens MRP3 protein.
Length = 1528
Score = 161 bits (390), Expect = 2e-38
Identities = 78/234 (33%), Positives = 142/234 (60%), Gaps = 2/234 (0%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
GE+ + Y D+ +L+ SLH+ GE V +VG +G GKS++ L R+ + +G
Sbjct: 1288 GEVEFRNYSVRYRPGLDL-VLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKG 1346
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+++DG N+ + + LRS L ++ Q+P+LF GT+ N+ + + ED++ E+++
Sbjct: 1347 EIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLD-PFGSYSEEDIWWALELSHL 1405
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
H F+ + P G + E G +LS GQ+Q + +AR+LLR+ +L+LDEAT+A+D ++ +
Sbjct: 1406 HTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLI 1465
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYH 528
QA + T LT++HRL+TI++ R++ +D+G + E + L+ A+G ++
Sbjct: 1466 QATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIFY 1519
Score = 139 bits (336), Expect = 6e-32
Identities = 79/255 (30%), Positives = 129/255 (50%), Gaps = 7/255 (2%)
Query: 891 VDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTV 950
V+G + W G + Y ++L+ + LHV G+ V +VG +G GKS++
Sbjct: 1275 VEGSRPPEGWPPRGEVEFRNYSVRYRPGL-DLVLRDLSLHVHGGEKVGIVGRTGAGKSSM 1333
Query: 951 LQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENI-AYGDNS 1009
+ R + G I +DG+++ + L+ LR QL ++ Q+PILF TL N+ +G S
Sbjct: 1334 TLCLFRILEAAKGEIRIDGLNVA-DIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYS 1392
Query: 1010 RKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLL 1069
++ H F+ S P G + +Q VC+ARAL+R R+L
Sbjct: 1393 E----EDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRIL 1448
Query: 1070 LLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNH 1129
+LDEAT+A+D ++ + + T +TIAHRL TI D + VLDKG + E +
Sbjct: 1449 VLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSP 1508
Query: 1130 AELIGLKGHYWQLSK 1144
A LI +G ++ +++
Sbjct: 1509 ANLIAARGIFYGMAR 1523
Score = 91.1 bits (216), Expect = 2e-17
Identities = 67/247 (27%), Positives = 119/247 (48%), Gaps = 22/247 (8%)
Query: 315 LKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSS 374
L + + G VA+VG GCGKS+++ L + +G V + G S
Sbjct: 645 LHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKG-------------S 691
Query: 375 LGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYR-VAEMAYAHEFIKNLPNGYETVIGERG 433
+ V Q+ + T+ +N+ G +A + Y+ E ++ LP G +T IGE+G
Sbjct: 692 VAYVPQQAWIQNCTLQENVLFG--KALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKG 749
Query: 434 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV---QAALDRASVGRTTLTV 490
+LSGGQ+QR+++AR++ + + LLD+ SA+D H K + + G+T + V
Sbjct: 750 INLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLV 809
Query: 491 SHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTS---GKETKEPEEIGTVL 547
+H +S + II + G + E G + L++ G + + + ++ E+ T L
Sbjct: 810 THGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTAL 869
Query: 548 EEQETKQ 554
E E K+
Sbjct: 870 EGAEDKE 876
Score = 66.1 bits (154), Expect = 7e-10
Identities = 50/219 (22%), Positives = 93/219 (42%), Gaps = 20/219 (9%)
Query: 924 LKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRK 983
L +D+ V G VA+VG GCGKS+++ + + G + + G
Sbjct: 645 LHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKG-------------- 690
Query: 984 QLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXX 1043
+ V Q+ + + TL EN+ +G + + LP G +T
Sbjct: 691 SVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLAD---LEMLPGGDQTEIGE 747
Query: 1044 XXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEAL---DHAAKGRTCI 1100
+QRV +ARA+ + LLD+ SA+D++ + + + + + G+T +
Sbjct: 748 KGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRV 807
Query: 1101 TIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHY 1139
+ H ++ + D I VL G++ E G + L+ G +
Sbjct: 808 LVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSF 846
>AB208954-1|BAD92191.1| 1533|Homo sapiens ATP-binding cassette,
sub-family C, member 3 isoform MRP3 variant protein.
Length = 1533
Score = 161 bits (390), Expect = 2e-38
Identities = 78/234 (33%), Positives = 142/234 (60%), Gaps = 2/234 (0%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
GE+ + Y D+ +L+ SLH+ GE V +VG +G GKS++ L R+ + +G
Sbjct: 1293 GEVEFRNYSVRYRPGLDL-VLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKG 1351
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+++DG N+ + + LRS L ++ Q+P+LF GT+ N+ + + ED++ E+++
Sbjct: 1352 EIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLD-PFGSYSEEDIWWALELSHL 1410
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
H F+ + P G + E G +LS GQ+Q + +AR+LLR+ +L+LDEAT+A+D ++ +
Sbjct: 1411 HTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLI 1470
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYH 528
QA + T LT++HRL+TI++ R++ +D+G + E + L+ A+G ++
Sbjct: 1471 QATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIFY 1524
Score = 139 bits (336), Expect = 6e-32
Identities = 79/255 (30%), Positives = 129/255 (50%), Gaps = 7/255 (2%)
Query: 891 VDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTV 950
V+G + W G + Y ++L+ + LHV G+ V +VG +G GKS++
Sbjct: 1280 VEGSRPPEGWPPRGEVEFRNYSVRYRPGL-DLVLRDLSLHVHGGEKVGIVGRTGAGKSSM 1338
Query: 951 LQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENI-AYGDNS 1009
+ R + G I +DG+++ + L+ LR QL ++ Q+PILF TL N+ +G S
Sbjct: 1339 TLCLFRILEAAKGEIRIDGLNVA-DIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYS 1397
Query: 1010 RKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLL 1069
++ H F+ S P G + +Q VC+ARAL+R R+L
Sbjct: 1398 E----EDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRIL 1453
Query: 1070 LLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNH 1129
+LDEAT+A+D ++ + + T +TIAHRL TI D + VLDKG + E +
Sbjct: 1454 VLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSP 1513
Query: 1130 AELIGLKGHYWQLSK 1144
A LI +G ++ +++
Sbjct: 1514 ANLIAARGIFYGMAR 1528
Score = 91.1 bits (216), Expect = 2e-17
Identities = 67/247 (27%), Positives = 119/247 (48%), Gaps = 22/247 (8%)
Query: 315 LKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSS 374
L + + G VA+VG GCGKS+++ L + +G V + G S
Sbjct: 650 LHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKG-------------S 696
Query: 375 LGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYR-VAEMAYAHEFIKNLPNGYETVIGERG 433
+ V Q+ + T+ +N+ G +A + Y+ E ++ LP G +T IGE+G
Sbjct: 697 VAYVPQQAWIQNCTLQENVLFG--KALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKG 754
Query: 434 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV---QAALDRASVGRTTLTV 490
+LSGGQ+QR+++AR++ + + LLD+ SA+D H K + + G+T + V
Sbjct: 755 INLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLV 814
Query: 491 SHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTS---GKETKEPEEIGTVL 547
+H +S + II + G + E G + L++ G + + + ++ E+ T L
Sbjct: 815 THGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTAL 874
Query: 548 EEQETKQ 554
E E K+
Sbjct: 875 EGAEDKE 881
Score = 66.1 bits (154), Expect = 7e-10
Identities = 50/219 (22%), Positives = 93/219 (42%), Gaps = 20/219 (9%)
Query: 924 LKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRK 983
L +D+ V G VA+VG GCGKS+++ + + G + + G
Sbjct: 650 LHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKG-------------- 695
Query: 984 QLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXX 1043
+ V Q+ + + TL EN+ +G + + LP G +T
Sbjct: 696 SVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLAD---LEMLPGGDQTEIGE 752
Query: 1044 XXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEAL---DHAAKGRTCI 1100
+QRV +ARA+ + LLD+ SA+D++ + + + + + G+T +
Sbjct: 753 KGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRV 812
Query: 1101 TIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHY 1139
+ H ++ + D I VL G++ E G + L+ G +
Sbjct: 813 LVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSF 851
>AB010887-1|BAA28146.1| 1527|Homo sapiens multidrug
resistance-associated protein(MRP)-like protein-2 (MLP-2)
protein.
Length = 1527
Score = 161 bits (390), Expect = 2e-38
Identities = 78/234 (33%), Positives = 142/234 (60%), Gaps = 2/234 (0%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
GE+ + Y D+ +L+ SLH+ GE V +VG +G GKS++ L R+ + +G
Sbjct: 1287 GEVEFRNYSVRYRPGLDL-VLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKG 1345
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+++DG N+ + + LRS L ++ Q+P+LF GT+ N+ + + ED++ E+++
Sbjct: 1346 EIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLD-PFGSYSEEDIWWALELSHL 1404
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
H F+ + P G + E G +LS GQ+Q + +AR+LLR+ +L+LDEAT+A+D ++ +
Sbjct: 1405 HTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLI 1464
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYH 528
QA + T LT++HRL+TI++ R++ +D+G + E + L+ A+G ++
Sbjct: 1465 QATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIFY 1518
Score = 139 bits (336), Expect = 6e-32
Identities = 79/255 (30%), Positives = 129/255 (50%), Gaps = 7/255 (2%)
Query: 891 VDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTV 950
V+G + W G + Y ++L+ + LHV G+ V +VG +G GKS++
Sbjct: 1274 VEGSRPPEGWPPRGEVEFRNYSVRYRPGL-DLVLRDLSLHVHGGEKVGIVGRTGAGKSSM 1332
Query: 951 LQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENI-AYGDNS 1009
+ R + G I +DG+++ + L+ LR QL ++ Q+PILF TL N+ +G S
Sbjct: 1333 TLCLFRILEAAKGEIRIDGLNVA-DIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYS 1391
Query: 1010 RKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLL 1069
++ H F+ S P G + +Q VC+ARAL+R R+L
Sbjct: 1392 E----EDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRIL 1447
Query: 1070 LLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNH 1129
+LDEAT+A+D ++ + + T +TIAHRL TI D + VLDKG + E +
Sbjct: 1448 VLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSP 1507
Query: 1130 AELIGLKGHYWQLSK 1144
A LI +G ++ +++
Sbjct: 1508 ANLIAARGIFYGMAR 1522
Score = 91.9 bits (218), Expect = 1e-17
Identities = 105/493 (21%), Positives = 210/493 (42%), Gaps = 41/493 (8%)
Query: 75 NLMKLKEGMGEKLAVVSNLVGTSIICLCTAFPLGWK----LALACITVMPFSIMASVALT 130
NLM + LA NL+ ++ + + A W+ LA + M I + A+
Sbjct: 411 NLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVA 470
Query: 131 NYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAFGGENIEVQRYKSLLEPAEISGSRRGL 190
+++M+ K E+L +K + + E +++ + + + E+ R
Sbjct: 471 VKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQ-GELQLLRTAA 529
Query: 191 FTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDANKPDDERTYIIGIVLSITFSVYMATQSI 250
+ F W+ + L T+ ++ + ++ N D E+ Y+ + +I + + +
Sbjct: 530 YLHTTTTFTWMCSPFLVTLITLW-VYVYVDPNNVLDAEKAYVSVSLFNI---LRLPLNML 585
Query: 251 TLCVPHMEVFATARGAAASIFSLLDKHPKIDCLSEAGSSPRRVIGEISLEDVHF-SYPSR 309
+ ++ + + S + P+ S R+ I +H ++
Sbjct: 586 PQLISNLTQASVSLKRIQQFLSQEELDPQ--------SVERKTISPGYAITIHSGTFTWA 637
Query: 310 SDIK-ILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNI 368
D+ L + + G VA+VG GCGKS+++ L + +G V + G
Sbjct: 638 QDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKG-------- 689
Query: 369 GWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYR-VAEMAYAHEFIKNLPNGYET 427
S+ V Q+ + T+ +N+ G +A + Y+ E ++ LP G +T
Sbjct: 690 -----SVAYVPQQAWIQNCTLQENVLFG--KALNPKRYQQTLEACALLADLEMLPGGDQT 742
Query: 428 VIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV---QAALDRASVG 484
IGE+G +LSGGQ+QR+++AR++ + + LLD+ SA+D H K + + G
Sbjct: 743 EIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAG 802
Query: 485 RTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTS---GKETKEPE 541
+T + V+H +S + II + G + E G + L++ G + + + ++ E
Sbjct: 803 KTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLE 862
Query: 542 EIGTVLEEQETKQ 554
+ T LE E K+
Sbjct: 863 DSWTALEGAEDKE 875
Score = 66.1 bits (154), Expect = 7e-10
Identities = 50/219 (22%), Positives = 93/219 (42%), Gaps = 20/219 (9%)
Query: 924 LKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRK 983
L +D+ V G VA+VG GCGKS+++ + + G + + G
Sbjct: 644 LHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKG-------------- 689
Query: 984 QLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXX 1043
+ V Q+ + + TL EN+ +G + + LP G +T
Sbjct: 690 SVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLAD---LEMLPGGDQTEIGE 746
Query: 1044 XXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEAL---DHAAKGRTCI 1100
+QRV +ARA+ + LLD+ SA+D++ + + + + + G+T +
Sbjct: 747 KGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRV 806
Query: 1101 TIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHY 1139
+ H ++ + D I VL G++ E G + L+ G +
Sbjct: 807 LVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSF 845
>AF083552-1|AAC34668.1| 1527|Homo sapiens canalicular multispecific
organic anion transporter 2 protein.
Length = 1527
Score = 159 bits (387), Expect = 4e-38
Identities = 77/234 (32%), Positives = 142/234 (60%), Gaps = 2/234 (0%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
GE+ + Y D+ +L+ SLH+ GE V +VG +G GKS++ L R+ + +G
Sbjct: 1287 GEVEFRNYSVRYRPGLDL-VLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKG 1345
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+++DG N+ + + +RS L ++ Q+P+LF GT+ N+ + + ED++ E+++
Sbjct: 1346 EIRIDGLNVADIGLHDVRSQLTIIPQDPILFSGTLRMNLD-PFGSYSEEDIWWALELSHL 1404
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
H F+ + P G + E G +LS GQ+Q + +AR+LLR+ +L+LDEAT+A+D ++ +
Sbjct: 1405 HTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLI 1464
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYH 528
QA + T LT++HRL+TI++ R++ +D+G + E + L+ A+G ++
Sbjct: 1465 QATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIFY 1518
Score = 138 bits (333), Expect = 1e-31
Identities = 78/255 (30%), Positives = 129/255 (50%), Gaps = 7/255 (2%)
Query: 891 VDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTV 950
V+G + W G + Y ++L+ + LHV G+ V +VG +G GKS++
Sbjct: 1274 VEGSRPPEGWPPRGEVEFRNYSVRYRPGL-DLVLRDLSLHVHGGEKVGIVGRTGAGKSSM 1332
Query: 951 LQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENI-AYGDNS 1009
+ R + G I +DG+++ + L+ +R QL ++ Q+PILF TL N+ +G S
Sbjct: 1333 TLCLFRILEAAKGEIRIDGLNVA-DIGLHDVRSQLTIIPQDPILFSGTLRMNLDPFGSYS 1391
Query: 1010 RKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLL 1069
++ H F+ S P G + +Q VC+ARAL+R R+L
Sbjct: 1392 E----EDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRIL 1447
Query: 1070 LLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNH 1129
+LDEAT+A+D ++ + + T +TIAHRL TI D + VLDKG + E +
Sbjct: 1448 VLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSP 1507
Query: 1130 AELIGLKGHYWQLSK 1144
A LI +G ++ +++
Sbjct: 1508 ANLIAARGIFYGMAR 1522
Score = 91.1 bits (216), Expect = 2e-17
Identities = 67/247 (27%), Positives = 119/247 (48%), Gaps = 22/247 (8%)
Query: 315 LKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSS 374
L + + G VA+VG GCGKS+++ L + +G V + G S
Sbjct: 644 LHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKG-------------S 690
Query: 375 LGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYR-VAEMAYAHEFIKNLPNGYETVIGERG 433
+ V Q+ + T+ +N+ G +A + Y+ E ++ LP G +T IGE+G
Sbjct: 691 VAYVPQQAWIQNCTLQENVLFG--KALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKG 748
Query: 434 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV---QAALDRASVGRTTLTV 490
+LSGGQ+QR+++AR++ + + LLD+ SA+D H K + + G+T + V
Sbjct: 749 INLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLV 808
Query: 491 SHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTS---GKETKEPEEIGTVL 547
+H +S + II + G + E G + L++ G + + + ++ E+ T L
Sbjct: 809 THGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTAL 868
Query: 548 EEQETKQ 554
E E K+
Sbjct: 869 EGAEDKE 875
Score = 66.1 bits (154), Expect = 7e-10
Identities = 50/219 (22%), Positives = 93/219 (42%), Gaps = 20/219 (9%)
Query: 924 LKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRK 983
L +D+ V G VA+VG GCGKS+++ + + G + + G
Sbjct: 644 LHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKG-------------- 689
Query: 984 QLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXX 1043
+ V Q+ + + TL EN+ +G + + LP G +T
Sbjct: 690 SVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLAD---LEMLPGGDQTEIGE 746
Query: 1044 XXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEAL---DHAAKGRTCI 1100
+QRV +ARA+ + LLD+ SA+D++ + + + + + G+T +
Sbjct: 747 KGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRV 806
Query: 1101 TIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHY 1139
+ H ++ + D I VL G++ E G + L+ G +
Sbjct: 807 LVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSF 845
>BC131732-1|AAI31733.1| 1503|Homo sapiens ATP-binding cassette,
sub-family C (CFTR/MRP), member 6 protein.
Length = 1503
Score = 156 bits (378), Expect = 5e-37
Identities = 79/236 (33%), Positives = 136/236 (57%), Gaps = 2/236 (0%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G+I D Y + + +G S I GE V +VG +G GKS++ L RL + +G
Sbjct: 1263 GQIEFRDFGLRYRPELPLAV-QGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEG 1321
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+ +DG + + + LRS + ++ Q+P+LF G++ N+ + E + E ++ E
Sbjct: 1322 GIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDL-LQEHSDEAIWAALETVQL 1380
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
+ +LP + +RG LS GQKQ + +AR+LLR+ +L+LDEAT+A+DP +E Q+
Sbjct: 1381 KALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQM 1440
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKL 530
QA L T L ++HRL ++++C R++ MD+G + E G+ +L+ KG +++L
Sbjct: 1441 QAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRL 1496
Score = 125 bits (301), Expect = 1e-27
Identities = 71/249 (28%), Positives = 126/249 (50%), Gaps = 5/249 (2%)
Query: 900 WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYD 959
W G D Y + ++G+ + AG+ V +VG +G GKS++ + R +
Sbjct: 1259 WPQGGQIEFRDFGLRYRPEL-PLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQE 1317
Query: 960 PTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXX 1019
G I +DGV I + L+ LR ++ ++ Q+PILF +L N+ D ++ + +
Sbjct: 1318 AAEGGIWIDGVPIAH-VGLHTLRSRISIIPQDPILFPGSLRMNL---DLLQEHSDEAIWA 1373
Query: 1020 XXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALD 1079
+ SLP + KQ +C+ARAL+R ++L+LDEAT+A+D
Sbjct: 1374 ALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVD 1433
Query: 1080 ANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHY 1139
+E + L T + IAHRL ++ D + V+DKG++ E G+ A+L+ KG +
Sbjct: 1434 PGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLF 1493
Query: 1140 WQLSKQQNV 1148
++L+++ +
Sbjct: 1494 YRLAQESGL 1502
Score = 103 bits (247), Expect = 4e-21
Identities = 114/484 (23%), Positives = 207/484 (42%), Gaps = 32/484 (6%)
Query: 98 IICLCTAFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKS 157
++C + L AL I V + + ++ + +M + +L++
Sbjct: 438 VVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRN 497
Query: 158 VKTVVAFGGENIEVQRYKSLLEPAEISGSRR-GLFTGLGNGFNWVLTYSLNTIGFMYGTR 216
KT+ G E + R + E+ R GL + V T+ + + F T
Sbjct: 498 SKTIKFHGWEGAFLDRVLGI-RGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAVHT- 555
Query: 217 LIIEDANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDK 276
L+ E+A E+ ++ VL+I + A + + + + + L +
Sbjct: 556 LVAENAMNA--EKAFVTLTVLNI---LNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEV 610
Query: 277 HPKIDCLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGC 336
P S +GS+ + I+++ F++ S L +L + G +A+VG G
Sbjct: 611 DPGAVDSSSSGSAAGKDC--ITIQSATFAWSQESP-PCLHRINLTVPQGCLLAVVGPVGA 667
Query: 337 GKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIG 396
GKS++L L +G V ++G ++ V QE + ++ +N+ G
Sbjct: 668 GKSSLLSALLGELSKVEGFVSIEG-------------AVAYVPQEAWVQNTSVVENVCFG 714
Query: 397 YPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAV 456
E + RV E + + P G T IGE+G +LSGGQKQR+++AR++ R+ AV
Sbjct: 715 Q-ELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAV 773
Query: 457 LLLDEATSALDPHSEKQV-QAALDRASV--GRTTLTVSHRLSTIVNCHRIICMDQGTIIE 513
LLD+ +ALD H + V + + G T + V+H L + II + G I E
Sbjct: 774 YLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAE 833
Query: 514 QGTHVELMKAKGFYHKLVTSGKETKEPEEIGTVLEEQETKQNGELQPAVRPEPDVKR-RS 572
G++ EL++ KG LV + ++P + G E T + P+++R RS
Sbjct: 834 MGSYQELLQRKG---ALVCLLDQARQPGDRGEGETEPGTSTKDPRGTSAGRRPELRRERS 890
Query: 573 VRKL 576
++ +
Sbjct: 891 IKSV 894
Score = 72.9 bits (171), Expect = 6e-12
Identities = 103/476 (21%), Positives = 191/476 (40%), Gaps = 45/476 (9%)
Query: 676 RESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTLVST-TF 734
R+++ VG V +S D + + L L G V ++ Y W+L S T
Sbjct: 401 RKASAVGDVVNLVSVDVQRLTESV-----LYLNGLWLPLVWIVVCFVYLWQLLGPSALTA 455
Query: 735 LPLMVGSIWLEGIMSQKSQQDEREAM---ESATAIATEAVVSIKTVQSLGIESLFITRFQ 791
+ + + + L +S+K + E M +S + + + + KT++ G E F+ R
Sbjct: 456 IAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTIKFHGWEGAFLDRVL 515
Query: 792 DALIDACAAVVKKSRWRGLVLGLCIY-VPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXXX 850
A+ R GL+ + + + ++ A++ AV
Sbjct: 516 GIRGQELGAL----RTSGLLFSVSLVSFQVSTFLVALVVFAVHTLVAENAMNAEKAFVTL 571
Query: 851 XMYGAYMLGQSLVYAP----SFNSAKTCGARILSIINREPRIRTVDGLNDKQDWSASGN- 905
+ +L ++ + P S A+ R+++ + E ++ SA+G
Sbjct: 572 TVLN--ILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEV--DPGAVDSSSSGSAAGKD 627
Query: 906 -FSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGN 964
+I F++ ++ L I+L V G +A+VG G GKS++L + G
Sbjct: 628 CITIQSATFAW-SQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGF 686
Query: 965 IELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXX 1024
+ ++G + V QE + + ++ EN+ +G P ++
Sbjct: 687 VSIEGA--------------VAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQ 732
Query: 1025 XXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDAN-SE 1083
+ S P+G T+ KQR+ +ARA+ R + LLD+ +ALDA+ +
Sbjct: 733 PD---VDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQ 789
Query: 1084 RAVTEALDHAA--KGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKG 1137
+ + +G T I + H L + AD I VL G I E G++ EL+ KG
Sbjct: 790 HVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKG 845
>AF076622-1|AAC79696.1| 1503|Homo sapiens MRP6 protein.
Length = 1503
Score = 156 bits (378), Expect = 5e-37
Identities = 79/236 (33%), Positives = 136/236 (57%), Gaps = 2/236 (0%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G+I D Y + + +G S I GE V +VG +G GKS++ L RL + +G
Sbjct: 1263 GQIEFRDFGLRYRPELPLAV-QGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEG 1321
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+ +DG + + + LRS + ++ Q+P+LF G++ N+ + E + E ++ E
Sbjct: 1322 GIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDL-LQEHSDEAIWAALETVQL 1380
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
+ +LP + +RG LS GQKQ + +AR+LLR+ +L+LDEAT+A+DP +E Q+
Sbjct: 1381 KALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQM 1440
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKL 530
QA L T L ++HRL ++++C R++ MD+G + E G+ +L+ KG +++L
Sbjct: 1441 QAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRL 1496
Score = 125 bits (301), Expect = 1e-27
Identities = 71/249 (28%), Positives = 126/249 (50%), Gaps = 5/249 (2%)
Query: 900 WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYD 959
W G D Y + ++G+ + AG+ V +VG +G GKS++ + R +
Sbjct: 1259 WPQGGQIEFRDFGLRYRPEL-PLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQE 1317
Query: 960 PTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXX 1019
G I +DGV I + L+ LR ++ ++ Q+PILF +L N+ D ++ + +
Sbjct: 1318 AAEGGIWIDGVPIAH-VGLHTLRSRISIIPQDPILFPGSLRMNL---DLLQEHSDEAIWA 1373
Query: 1020 XXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALD 1079
+ SLP + KQ +C+ARAL+R ++L+LDEAT+A+D
Sbjct: 1374 ALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVD 1433
Query: 1080 ANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHY 1139
+E + L T + IAHRL ++ D + V+DKG++ E G+ A+L+ KG +
Sbjct: 1434 PGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLF 1493
Query: 1140 WQLSKQQNV 1148
++L+++ +
Sbjct: 1494 YRLAQESGL 1502
Score = 104 bits (249), Expect = 2e-21
Identities = 114/484 (23%), Positives = 207/484 (42%), Gaps = 32/484 (6%)
Query: 98 IICLCTAFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKS 157
++C + L AL I V + + ++ + +M + +L++
Sbjct: 438 VVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRN 497
Query: 158 VKTVVAFGGENIEVQRYKSLLEPAEISGSRR-GLFTGLGNGFNWVLTYSLNTIGFMYGTR 216
KT+ G E + R + E+ R GL + V T+ + + F T
Sbjct: 498 SKTIKFHGWEGAFLDRVLGI-RGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAVHT- 555
Query: 217 LIIEDANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDK 276
L+ E+A E+ ++ VL+I + A + + + + + L +
Sbjct: 556 LVAENAMNA--EKAFVTLTVLNI---LNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEV 610
Query: 277 HPKIDCLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGC 336
P + S +GS+ + I++ F++ S L +L + G +A+VG G
Sbjct: 611 DPGVVDSSSSGSAAGKDC--ITIHSATFAWSQESP-PCLHRINLTVPQGCLLAVVGPVGA 667
Query: 337 GKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIG 396
GKS++L L +G V ++G ++ V QE + ++ +N+ G
Sbjct: 668 GKSSLLSALLGELSKVEGFVSIEG-------------AVAYVPQEAWVQNTSVVENVCFG 714
Query: 397 YPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAV 456
E + RV E + + P G T IGE+G +LSGGQKQR+++AR++ R+ AV
Sbjct: 715 Q-ELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAV 773
Query: 457 LLLDEATSALDPHSEKQV-QAALDRASV--GRTTLTVSHRLSTIVNCHRIICMDQGTIIE 513
LLD+ +ALD H + V + + G T + V+H L + II + G I E
Sbjct: 774 YLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAE 833
Query: 514 QGTHVELMKAKGFYHKLVTSGKETKEPEEIGTVLEEQETKQNGELQPAVRPEPDVKR-RS 572
G++ EL++ KG LV + ++P + G E T + P+++R RS
Sbjct: 834 MGSYQELLQRKG---ALVCLLDQARQPGDRGEGETEPGTSTKDPRGTSAGRRPELRRERS 890
Query: 573 VRKL 576
++ +
Sbjct: 891 IKSV 894
Score = 73.7 bits (173), Expect = 3e-12
Identities = 104/476 (21%), Positives = 193/476 (40%), Gaps = 45/476 (9%)
Query: 676 RESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTLVST-TF 734
R+++ VG V +S D + + L L G V ++ Y W+L S T
Sbjct: 401 RKASAVGDVVNLVSVDVQRLTESV-----LYLNGLWLPLVWIVVCFVYLWQLLGPSALTA 455
Query: 735 LPLMVGSIWLEGIMSQKSQQDEREAM---ESATAIATEAVVSIKTVQSLGIESLFITRFQ 791
+ + + + L +S+K + E M +S + + + + KT++ G E F+ R
Sbjct: 456 IAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTIKFHGWEGAFLDRVL 515
Query: 792 DALIDACAAVVKKSRWRGLVLGLCIY-VPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXXX 850
A+ R GL+ + + + ++ A++ AV
Sbjct: 516 GIRGQELGAL----RTSGLLFSVSLVSFQVSTFLVALVVFAVHTLVAENAMNAEKAFVTL 571
Query: 851 XMYGAYMLGQSLVYAP----SFNSAKTCGARILSIINREPRIRTVDGLNDKQDWSASGN- 905
+ +L ++ + P S A+ R+++ + E V ++ SA+G
Sbjct: 572 TVLN--ILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDPGV--VDSSSSGSAAGKD 627
Query: 906 -FSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGN 964
+I+ F++ ++ L I+L V G +A+VG G GKS++L + G
Sbjct: 628 CITIHSATFAW-SQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGF 686
Query: 965 IELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXX 1024
+ ++G + V QE + + ++ EN+ +G P ++
Sbjct: 687 VSIEGA--------------VAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQ 732
Query: 1025 XXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDAN-SE 1083
+ S P+G T+ KQR+ +ARA+ R + LLD+ +ALDA+ +
Sbjct: 733 PD---VDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQ 789
Query: 1084 RAVTEALDHAA--KGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKG 1137
+ + +G T I + H L + AD I VL G I E G++ EL+ KG
Sbjct: 790 HVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKG 845
>AF168791-1|AAD51293.1| 1503|Homo sapiens multi-specific organic anion
tranporter-E protein.
Length = 1503
Score = 155 bits (376), Expect = 9e-37
Identities = 80/237 (33%), Positives = 139/237 (58%), Gaps = 4/237 (1%)
Query: 295 GEISLEDVHFSYPSRSDIKI-LKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQ 353
G+I D F R ++ + ++G S I GE V +VG +G GKS++ L RL + +
Sbjct: 1263 GQIEFRD--FGLRCRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAE 1320
Query: 354 GSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAY 413
G + +DG + + + LRS + ++ Q+P+LF G++ N+ + E + E ++ E
Sbjct: 1321 GGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDL-LQEHSDEAIWAALETVQ 1379
Query: 414 AHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQ 473
+ +LP + +RG LS GQKQ + +AR+LLR+ +L+LDEAT+A+DP +E Q
Sbjct: 1380 LKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQ 1439
Query: 474 VQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKL 530
+QA L T L ++HRL ++++C R++ MD+G + E G+ +L+ KG +++L
Sbjct: 1440 MQAMLGSWFAQCTVLPIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRL 1496
Score = 122 bits (295), Expect = 6e-27
Identities = 72/250 (28%), Positives = 127/250 (50%), Gaps = 7/250 (2%)
Query: 900 WSASGNFSINDVEFSYPTRAH-QMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFY 958
W G D F R + ++G+ + AG+ V +VG +G GKS++ + R
Sbjct: 1259 WPQGGQIEFRD--FGLRCRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQ 1316
Query: 959 DPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXX 1018
+ G I +DGV I + L+ LR ++ ++ Q+PILF +L N+ D ++ + +
Sbjct: 1317 EAAEGGIWIDGVPIAH-VGLHTLRSRISIIPQDPILFPGSLRMNL---DLLQEHSDEAIW 1372
Query: 1019 XXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSAL 1078
+ SLP + KQ +C+ARAL+R ++L+LDEAT+A+
Sbjct: 1373 AALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAV 1432
Query: 1079 DANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGH 1138
D +E + L T + IAHRL ++ D + V+DKG++ E G+ A+L+ KG
Sbjct: 1433 DPGTELQMQAMLGSWFAQCTVLPIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGL 1492
Query: 1139 YWQLSKQQNV 1148
+++L+++ +
Sbjct: 1493 FYRLAQESGL 1502
Score = 104 bits (249), Expect = 2e-21
Identities = 114/484 (23%), Positives = 207/484 (42%), Gaps = 32/484 (6%)
Query: 98 IICLCTAFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKS 157
++C + L AL I V + + ++ + +M + +L++
Sbjct: 438 VVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRN 497
Query: 158 VKTVVAFGGENIEVQRYKSLLEPAEISGSRR-GLFTGLGNGFNWVLTYSLNTIGFMYGTR 216
KT+ G E + R + E+ R GL + V T+ + + F T
Sbjct: 498 SKTIKFHGWEGAFLDRVLGI-RGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAVHT- 555
Query: 217 LIIEDANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDK 276
L+ E+A E+ ++ VL+I + A + + + + + L +
Sbjct: 556 LVAENAMNA--EKAFVTLTVLNI---LNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEV 610
Query: 277 HPKIDCLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGC 336
P + S +GS+ + I++ F++ S L +L + G +A+VG G
Sbjct: 611 DPGVVDSSSSGSAAGKDC--ITIHSATFAWSQESP-PCLHRINLTVPQGCLLAVVGPVGA 667
Query: 337 GKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIG 396
GKS++L L +G V ++G ++ V QE + ++ +N+ G
Sbjct: 668 GKSSLLSALLGELSKVEGFVSIEG-------------AVAYVPQEAWVQNTSVVENVCFG 714
Query: 397 YPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAV 456
E + RV E + + P G T IGE+G +LSGGQKQR+++AR++ R+ AV
Sbjct: 715 Q-ELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAV 773
Query: 457 LLLDEATSALDPHSEKQV-QAALDRASV--GRTTLTVSHRLSTIVNCHRIICMDQGTIIE 513
LLD+ +ALD H + V + + G T + V+H L + II + G I E
Sbjct: 774 YLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAE 833
Query: 514 QGTHVELMKAKGFYHKLVTSGKETKEPEEIGTVLEEQETKQNGELQPAVRPEPDVKR-RS 572
G++ EL++ KG LV + ++P + G E T + P+++R RS
Sbjct: 834 MGSYQELLQRKG---ALVCLLDQARQPGDRGEGETEPGTSTKDPRGTSAGRRPELRRERS 890
Query: 573 VRKL 576
++ +
Sbjct: 891 IKSV 894
Score = 73.7 bits (173), Expect = 3e-12
Identities = 104/476 (21%), Positives = 193/476 (40%), Gaps = 45/476 (9%)
Query: 676 RESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTLVST-TF 734
R+++ VG V +S D + + L L G V ++ Y W+L S T
Sbjct: 401 RKASAVGDVVNLVSVDVQRLTESV-----LYLNGLWLPLVWIVVCFVYLWQLLGPSALTA 455
Query: 735 LPLMVGSIWLEGIMSQKSQQDEREAM---ESATAIATEAVVSIKTVQSLGIESLFITRFQ 791
+ + + + L +S+K + E M +S + + + + KT++ G E F+ R
Sbjct: 456 IAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTIKFHGWEGAFLDRVL 515
Query: 792 DALIDACAAVVKKSRWRGLVLGLCIY-VPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXXX 850
A+ R GL+ + + + ++ A++ AV
Sbjct: 516 GIRGQELGAL----RTSGLLFSVSLVSFQVSTFLVALVVFAVHTLVAENAMNAEKAFVTL 571
Query: 851 XMYGAYMLGQSLVYAP----SFNSAKTCGARILSIINREPRIRTVDGLNDKQDWSASGN- 905
+ +L ++ + P S A+ R+++ + E V ++ SA+G
Sbjct: 572 TVLN--ILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDPGV--VDSSSSGSAAGKD 627
Query: 906 -FSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGN 964
+I+ F++ ++ L I+L V G +A+VG G GKS++L + G
Sbjct: 628 CITIHSATFAW-SQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGF 686
Query: 965 IELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXX 1024
+ ++G + V QE + + ++ EN+ +G P ++
Sbjct: 687 VSIEGA--------------VAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQ 732
Query: 1025 XXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDAN-SE 1083
+ S P+G T+ KQR+ +ARA+ R + LLD+ +ALDA+ +
Sbjct: 733 PD---VDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQ 789
Query: 1084 RAVTEALDHAA--KGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKG 1137
+ + +G T I + H L + AD I VL G I E G++ EL+ KG
Sbjct: 790 HVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKG 845
>X95715-1|CAA65019.1| 453|Homo sapiens anthracycline resistance
associated protein protein.
Length = 453
Score = 155 bits (375), Expect = 1e-36
Identities = 79/236 (33%), Positives = 135/236 (57%), Gaps = 2/236 (0%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G+I D Y + + +G S I GE V +VG +G GKS++ L RL + +G
Sbjct: 213 GQIEFRDFGLRYRPELPLAV-QGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEG 271
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+ +DG + + + LRS + ++ Q+P+LF G++ N+ + E + E ++ E
Sbjct: 272 GIWIDGVPIAHVGVHTLRSRISIIPQDPILFPGSLRMNLDL-LQEHSDEAIWAALETVQL 330
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
+ LP + +RG LS GQKQ + +AR+LLR+ +L+LDEAT+A+DP +E Q+
Sbjct: 331 KALVACLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQM 390
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKL 530
QA L T L ++HRL ++++C R++ MD+G + E G+ +L+ KG +++L
Sbjct: 391 QAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRL 446
Score = 122 bits (293), Expect = 1e-26
Identities = 69/249 (27%), Positives = 125/249 (50%), Gaps = 5/249 (2%)
Query: 900 WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYD 959
W G D Y + ++G+ + AG+ V +VG +G GKS++ + R +
Sbjct: 209 WPQGGQIEFRDFGLRYRPEL-PLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQE 267
Query: 960 PTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXX 1019
G I +DGV I + ++ LR ++ ++ Q+PILF +L N+ D ++ + +
Sbjct: 268 AAEGGIWIDGVPIAH-VGVHTLRSRISIIPQDPILFPGSLRMNL---DLLQEHSDEAIWA 323
Query: 1020 XXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALD 1079
+ LP + KQ +C+ARAL+R ++L+LDEAT+A+D
Sbjct: 324 ALETVQLKALVACLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVD 383
Query: 1080 ANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHY 1139
+E + L T + IAHRL ++ D + V+DKG++ E G+ A+L+ KG +
Sbjct: 384 PGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLF 443
Query: 1140 WQLSKQQNV 1148
++L+++ +
Sbjct: 444 YRLAQESGL 452
>U83659-1|AAB71756.1| 485|Homo sapiens multidrug
resistance-associated protein homolog protein.
Length = 485
Score = 153 bits (372), Expect = 3e-36
Identities = 73/234 (31%), Positives = 139/234 (59%), Gaps = 2/234 (0%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
GE+ + Y D+ +L+ SLH+ GE V +VG +G GKS++ R+ + +G
Sbjct: 245 GEVEFRNYSVRYRPGLDL-VLRDLSLHVHGGEKVGIVGRTGAGKSSMTLACSRILEAAKG 303
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+++DG N+ + +R + ++ ++P+LF GT+ N+ + + ED++ E+++
Sbjct: 304 EIRIDGLNVADIGFHDVRCQMTIIPRDPILFSGTLRMNLD-PFGSYSEEDIWWALELSHL 362
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
H F+ + P G + E G +LS GQ+Q + +AR+LLR+ +L+LDEAT+A+D ++ +
Sbjct: 363 HTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLI 422
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYH 528
QA + T LT++HRL+TI++ R++ +D+G + E + L+ A+G ++
Sbjct: 423 QATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIFY 476
Score = 132 bits (320), Expect = 5e-30
Identities = 75/255 (29%), Positives = 127/255 (49%), Gaps = 7/255 (2%)
Query: 891 VDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTV 950
V+G + W G + Y ++L+ + LHV G+ V +VG +G GKS++
Sbjct: 232 VEGSRPPEGWPPRGEVEFRNYSVRYRPGL-DLVLRDLSLHVHGGEKVGIVGRTGAGKSSM 290
Query: 951 LQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENI-AYGDNS 1009
R + G I +DG+++ + + +R Q+ ++ ++PILF TL N+ +G S
Sbjct: 291 TLACSRILEAAKGEIRIDGLNVA-DIGFHDVRCQMTIIPRDPILFSGTLRMNLDPFGSYS 349
Query: 1010 RKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLL 1069
++ H F+ S P G + +Q VC+ARAL+R R+L
Sbjct: 350 E----EDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRIL 405
Query: 1070 LLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNH 1129
+LDEAT+A+D ++ + + T +TIAHRL TI D + VLDKG + E +
Sbjct: 406 VLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSP 465
Query: 1130 AELIGLKGHYWQLSK 1144
A LI +G ++ +++
Sbjct: 466 ANLIAARGIFYGMAR 480
>U49248-1|AAB09422.1| 1545|Homo sapiens canalicular multispecific
organic anion transporter protein.
Length = 1545
Score = 153 bits (370), Expect = 5e-36
Identities = 122/516 (23%), Positives = 245/516 (47%), Gaps = 35/516 (6%)
Query: 35 WSALKQI---TTIRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKL-AVV 90
WSA + + K L +LR M +FDT + ++ + ++ + + + + L + +
Sbjct: 1044 WSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRIVNRFAGDISTVDDTLPQSLRSWI 1103
Query: 91 SNLVG--TSIICLCTAFPLGWKLALACITVMPFSIM-ASVALTNYQTKSSIREMESYSQA 147
+ +G ++++ +C A P+ I V+P I+ SV + T +R ++S +++
Sbjct: 1104 TCFLGIISTLVMICMATPV------FTIIVIPLGIIYVSVQMFYVSTSRQLRRLDSVTRS 1157
Query: 148 G--KQAEEVLKSVKTVVAFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYS 205
E + + + AF + QR+ E I +++ +F+ + + W L
Sbjct: 1158 PIYSHFSETVSGLPVIRAFEHQ----QRFLKHNEE-RIDTNQKCVFSWITSN-RW-LAIR 1210
Query: 206 LNTIG----FMYGTRLIIEDANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFA 261
L +G F ++I D +G VLS ++ + +E
Sbjct: 1211 LELVGNLTVFFSALMMVIYRDTLSGDT----VGFVLSNALNITQTLNWLVRMTSEIETNI 1266
Query: 262 TARGAAASIFSLLDKHPKIDCLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLH 321
A + ++ P + P + G+I + Y D+ +L+G +
Sbjct: 1267 VAVERITEYTKVENEAPWVTDKRPPPDWPSK--GKIQFNNYQVRYRPELDL-VLRGITCD 1323
Query: 322 IKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQE 381
I E + +VG +G GKS++ L R+ + G + +DG ++ ++ + LR L ++ Q+
Sbjct: 1324 IGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQD 1383
Query: 382 PVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQK 441
P+LF G++ N+ + + E++++ E+A+ F+ +L G + E G +LS GQ+
Sbjct: 1384 PILFSGSLRMNLD-PFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQR 1442
Query: 442 QRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCH 501
Q + + R+LLR+ +L+LDEAT+A+D ++ +Q + T +T++HRL TI++
Sbjct: 1443 QLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSD 1502
Query: 502 RIICMDQGTIIEQGTHVELMKAKG-FYHKLVTSGKE 536
+++ +D G IIE G+ EL++ G FY +G E
Sbjct: 1503 KVMVLDNGKIIEYGSPEELLQIPGPFYFMAKEAGIE 1538
Score = 144 bits (348), Expect = 2e-33
Identities = 78/250 (31%), Positives = 134/250 (53%), Gaps = 5/250 (2%)
Query: 899 DWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFY 958
DW + G N+ + Y ++L+GI + + + + +VG +G GKS++ + R
Sbjct: 1293 DWPSKGKIQFNNYQVRYRPEL-DLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRIL 1351
Query: 959 DPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXX 1018
+ G I +DGVDI S+ L+ LR++L ++ Q+PILF +L N+ D + +E
Sbjct: 1352 EAAGGQIIIDGVDIA-SIGLHDLREKLTIIPQDPILFSGSLRMNL---DPFNNYSDEEIW 1407
Query: 1019 XXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSAL 1078
+F+ SL G +Q +C+ RAL+R ++L+LDEAT+A+
Sbjct: 1408 KALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAV 1467
Query: 1079 DANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGH 1138
D ++ + + + T ITIAHRL TI D+D + VLD GKI+E G+ EL+ + G
Sbjct: 1468 DLETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIEYGSPEELLQIPGP 1527
Query: 1139 YWQLSKQQNV 1148
++ ++K+ +
Sbjct: 1528 FYFMAKEAGI 1537
Score = 101 bits (243), Expect = 1e-20
Identities = 73/262 (27%), Positives = 126/262 (48%), Gaps = 18/262 (6%)
Query: 297 ISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSV 356
+ + F++ S+ + + +L I G+ VA++G G GKS+++ + + G +
Sbjct: 637 MQFSEASFTWEHDSEATV-RDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHI 695
Query: 357 KLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHE 416
+ G W+++ GTI DNI G E + +V E
Sbjct: 696 TIKGTTAYVPQQSWIQN-------------GTIKDNILFG-TEFNEKRYQQVLEACALLP 741
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-Q 475
++ LP G IGE+G +LSGGQKQRI++AR+ + + LLD+ SA+D H K +
Sbjct: 742 DLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFN 801
Query: 476 AALDRASV--GRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTS 533
L + G+T L V+H + + I+ + GTI+E+G++ L+ KG + K + +
Sbjct: 802 KVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLKT 861
Query: 534 GKETKEPEEIGTVLEEQETKQN 555
PEE TV + E + +
Sbjct: 862 FLRHTGPEEEATVHDGSEEEDD 883
Score = 66.5 bits (155), Expect = 5e-10
Identities = 52/219 (23%), Positives = 98/219 (44%), Gaps = 20/219 (9%)
Query: 924 LKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRK 983
++ ++L + AG+ VA++G G GKS+++ + + G+I + G
Sbjct: 654 VRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTT------------ 701
Query: 984 QLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXX 1043
V Q+ + + T+ +NI +G + + + LP G
Sbjct: 702 --AYVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEACALLPD---LEMLPGGDLAEIGE 756
Query: 1044 XXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEAL---DHAAKGRTCI 1100
KQR+ +ARA ++ + LLD+ SA+DA+ + + + + KG+T +
Sbjct: 757 KGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRL 816
Query: 1101 TIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHY 1139
+ H + + D I VL G IVEKG+++ L+ KG +
Sbjct: 817 LVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEF 855
>X96395-1|CAA65259.2| 1545|Homo sapiens canalicular multidrug
resistance protein protein.
Length = 1545
Score = 152 bits (369), Expect = 6e-36
Identities = 122/516 (23%), Positives = 245/516 (47%), Gaps = 35/516 (6%)
Query: 35 WSALKQI---TTIRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKL-AVV 90
WSA + + K L +LR M +FDT + ++ + ++ + + + + L + +
Sbjct: 1044 WSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRIVNRFAGDISTVDDTLPQSLRSWI 1103
Query: 91 SNLVG--TSIICLCTAFPLGWKLALACITVMPFSIM-ASVALTNYQTKSSIREMESYSQA 147
+ +G ++++ +C A P+ I V+P I+ SV + T +R ++S +++
Sbjct: 1104 TCFLGIISTLVMICMATPV------FTIIVIPLGIIYVSVQMFYVSTSRQLRRLDSVTRS 1157
Query: 148 G--KQAEEVLKSVKTVVAFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYS 205
E + + + AF + QR+ E I +++ +F+ + + W L
Sbjct: 1158 PIYSHFSETVSGLPVIRAFEHQ----QRFLKHNE-VRIDTNQKCVFSWITSN-RW-LAIR 1210
Query: 206 LNTIG----FMYGTRLIIEDANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFA 261
L +G F ++I D +G VLS ++ + +E
Sbjct: 1211 LELVGNLTVFFSALMMVIYRDTLSGDT----VGFVLSNALNITQTLNWLVRMTSEIETNI 1266
Query: 262 TARGAAASIFSLLDKHPKIDCLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLH 321
A + ++ P + P + G+I + Y D+ +L+G +
Sbjct: 1267 VAVERITEYTKVENEAPWVTDKRPPPDWPSK--GKIQFNNYQVRYRPELDL-VLRGITCD 1323
Query: 322 IKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQE 381
I E + +VG +G GKS++ L R+ + G + +DG ++ ++ + LR L ++ Q+
Sbjct: 1324 IGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQD 1383
Query: 382 PVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQK 441
P+LF G++ N+ + + E++++ E+A+ F+ +L G + E G +LS GQ+
Sbjct: 1384 PILFSGSLRMNLD-PFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQR 1442
Query: 442 QRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCH 501
Q + + R+LLR+ +L+LDEAT+A+D ++ +Q + T +T++HRL TI++
Sbjct: 1443 QLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSD 1502
Query: 502 RIICMDQGTIIEQGTHVELMKAKG-FYHKLVTSGKE 536
+++ +D G IIE G+ EL++ G FY +G E
Sbjct: 1503 KVMVLDNGKIIECGSPEELLQIPGPFYFMAKEAGIE 1538
Score = 143 bits (347), Expect = 3e-33
Identities = 78/250 (31%), Positives = 134/250 (53%), Gaps = 5/250 (2%)
Query: 899 DWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFY 958
DW + G N+ + Y ++L+GI + + + + +VG +G GKS++ + R
Sbjct: 1293 DWPSKGKIQFNNYQVRYRPEL-DLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRIL 1351
Query: 959 DPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXX 1018
+ G I +DGVDI S+ L+ LR++L ++ Q+PILF +L N+ D + +E
Sbjct: 1352 EAAGGQIIIDGVDIA-SIGLHDLREKLTIIPQDPILFSGSLRMNL---DPFNNYSDEEIW 1407
Query: 1019 XXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSAL 1078
+F+ SL G +Q +C+ RAL+R ++L+LDEAT+A+
Sbjct: 1408 KALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAV 1467
Query: 1079 DANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGH 1138
D ++ + + + T ITIAHRL TI D+D + VLD GKI+E G+ EL+ + G
Sbjct: 1468 DLETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGP 1527
Query: 1139 YWQLSKQQNV 1148
++ ++K+ +
Sbjct: 1528 FYFMAKEAGI 1537
Score = 101 bits (243), Expect = 1e-20
Identities = 73/262 (27%), Positives = 126/262 (48%), Gaps = 18/262 (6%)
Query: 297 ISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSV 356
+ + F++ S+ + + +L I G+ VA++G G GKS+++ + + G +
Sbjct: 637 MQFSEASFTWEHDSEATV-RDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHI 695
Query: 357 KLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHE 416
+ G W+++ GTI DNI G E + +V E
Sbjct: 696 TIKGTTAYVPQQSWIQN-------------GTIKDNILFG-TEFNEKRYQQVLEACALLP 741
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-Q 475
++ LP G IGE+G +LSGGQKQRI++AR+ + + LLD+ SA+D H K +
Sbjct: 742 DLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFN 801
Query: 476 AALDRASV--GRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTS 533
L + G+T L V+H + + I+ + GTI+E+G++ L+ KG + K + +
Sbjct: 802 KVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLKT 861
Query: 534 GKETKEPEEIGTVLEEQETKQN 555
PEE TV + E + +
Sbjct: 862 FLRHTGPEEEATVHDGSEEEDD 883
Score = 66.5 bits (155), Expect = 5e-10
Identities = 52/219 (23%), Positives = 98/219 (44%), Gaps = 20/219 (9%)
Query: 924 LKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRK 983
++ ++L + AG+ VA++G G GKS+++ + + G+I + G
Sbjct: 654 VRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTT------------ 701
Query: 984 QLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXX 1043
V Q+ + + T+ +NI +G + + + LP G
Sbjct: 702 --AYVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEACALLPD---LEMLPGGDLAEIGE 756
Query: 1044 XXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEAL---DHAAKGRTCI 1100
KQR+ +ARA ++ + LLD+ SA+DA+ + + + + KG+T +
Sbjct: 757 KGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRL 816
Query: 1101 TIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHY 1139
+ H + + D I VL G IVEKG+++ L+ KG +
Sbjct: 817 LVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEF 855
>U63970-1|AAB39892.1| 1545|Homo sapiens canalicular multispecific
organic anion transporter protein.
Length = 1545
Score = 152 bits (369), Expect = 6e-36
Identities = 122/516 (23%), Positives = 245/516 (47%), Gaps = 35/516 (6%)
Query: 35 WSALKQI---TTIRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKL-AVV 90
WSA + + K L +LR M +FDT + ++ + ++ + + + + L + +
Sbjct: 1044 WSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRIVNRFAGDISTVDDTLPQSLRSWI 1103
Query: 91 SNLVG--TSIICLCTAFPLGWKLALACITVMPFSIM-ASVALTNYQTKSSIREMESYSQA 147
+ +G ++++ +C A P+ I V+P I+ SV + T +R ++S +++
Sbjct: 1104 TCFLGIISTLVMICMATPV------FTIIVIPLGIIYVSVQMFYVSTSRQLRRLDSVTRS 1157
Query: 148 G--KQAEEVLKSVKTVVAFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYS 205
E + + + AF + QR+ E I +++ +F+ + + W L
Sbjct: 1158 PIYSHFSETVSGLPVIRAFEHQ----QRFLKHNE-VRIDTNQKCVFSWITSN-RW-LAIR 1210
Query: 206 LNTIG----FMYGTRLIIEDANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFA 261
L +G F ++I D +G VLS ++ + +E
Sbjct: 1211 LELVGNLTVFFSALMMVIYRDTLSGDT----VGFVLSNALNITQTLNWLVRMTSEIETNI 1266
Query: 262 TARGAAASIFSLLDKHPKIDCLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLH 321
A + ++ P + P + G+I + Y D+ +L+G +
Sbjct: 1267 VAVERITEYTKVENEAPWVTDKRPPPDWPSK--GKIQFNNYQVRYRPELDL-VLRGITCD 1323
Query: 322 IKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQE 381
I E + +VG +G GKS++ L R+ + G + +DG ++ ++ + LR L ++ Q+
Sbjct: 1324 IGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQD 1383
Query: 382 PVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQK 441
P+LF G++ N+ + + E++++ E+A+ F+ +L G + E G +LS GQ+
Sbjct: 1384 PILFSGSLRMNLD-PFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQR 1442
Query: 442 QRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCH 501
Q + + R+LLR+ +L+LDEAT+A+D ++ +Q + T +T++HRL TI++
Sbjct: 1443 QLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSD 1502
Query: 502 RIICMDQGTIIEQGTHVELMKAKG-FYHKLVTSGKE 536
+++ +D G IIE G+ EL++ G FY +G E
Sbjct: 1503 KVMVLDNGKIIECGSPEELLQIPGPFYFMAKEAGIE 1538
Score = 143 bits (347), Expect = 3e-33
Identities = 78/250 (31%), Positives = 134/250 (53%), Gaps = 5/250 (2%)
Query: 899 DWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFY 958
DW + G N+ + Y ++L+GI + + + + +VG +G GKS++ + R
Sbjct: 1293 DWPSKGKIQFNNYQVRYRPEL-DLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRIL 1351
Query: 959 DPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXX 1018
+ G I +DGVDI S+ L+ LR++L ++ Q+PILF +L N+ D + +E
Sbjct: 1352 EAAGGQIIIDGVDIA-SIGLHDLREKLTIIPQDPILFSGSLRMNL---DPFNNYSDEEIW 1407
Query: 1019 XXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSAL 1078
+F+ SL G +Q +C+ RAL+R ++L+LDEAT+A+
Sbjct: 1408 KALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAV 1467
Query: 1079 DANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGH 1138
D ++ + + + T ITIAHRL TI D+D + VLD GKI+E G+ EL+ + G
Sbjct: 1468 DLETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGP 1527
Query: 1139 YWQLSKQQNV 1148
++ ++K+ +
Sbjct: 1528 FYFMAKEAGI 1537
Score = 101 bits (243), Expect = 1e-20
Identities = 73/262 (27%), Positives = 126/262 (48%), Gaps = 18/262 (6%)
Query: 297 ISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSV 356
+ + F++ S+ + + +L I G+ VA++G G GKS+++ + + G +
Sbjct: 637 MQFSEASFTWEHDSEATV-RDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHI 695
Query: 357 KLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHE 416
+ G W+++ GTI DNI G E + +V E
Sbjct: 696 TIKGTTAYVPQQSWIQN-------------GTIKDNILFG-TEFNEKRYQQVLEACALLP 741
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-Q 475
++ LP G IGE+G +LSGGQKQRI++AR+ + + LLD+ SA+D H K +
Sbjct: 742 DLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFN 801
Query: 476 AALDRASV--GRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTS 533
L + G+T L V+H + + I+ + GTI+E+G++ L+ KG + K + +
Sbjct: 802 KVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLKT 861
Query: 534 GKETKEPEEIGTVLEEQETKQN 555
PEE TV + E + +
Sbjct: 862 FLRHTGPEEEATVHDGSEEEDD 883
Score = 66.5 bits (155), Expect = 5e-10
Identities = 52/219 (23%), Positives = 98/219 (44%), Gaps = 20/219 (9%)
Query: 924 LKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRK 983
++ ++L + AG+ VA++G G GKS+++ + + G+I + G
Sbjct: 654 VRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTT------------ 701
Query: 984 QLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXX 1043
V Q+ + + T+ +NI +G + + + LP G
Sbjct: 702 --AYVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEACALLPD---LEMLPGGDLAEIGE 756
Query: 1044 XXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEAL---DHAAKGRTCI 1100
KQR+ +ARA ++ + LLD+ SA+DA+ + + + + KG+T +
Sbjct: 757 KGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRL 816
Query: 1101 TIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHY 1139
+ H + + D I VL G IVEKG+++ L+ KG +
Sbjct: 817 LVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEF 855
>AL392107-3|CAI11010.1| 1545|Homo sapiens ATP-binding cassette,
sub-family C (CFTR/MRP), member 2 protein.
Length = 1545
Score = 152 bits (369), Expect = 6e-36
Identities = 122/516 (23%), Positives = 245/516 (47%), Gaps = 35/516 (6%)
Query: 35 WSALKQI---TTIRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKL-AVV 90
WSA + + K L +LR M +FDT + ++ + ++ + + + + L + +
Sbjct: 1044 WSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRIVNRFAGDISTVDDTLPQSLRSWI 1103
Query: 91 SNLVG--TSIICLCTAFPLGWKLALACITVMPFSIM-ASVALTNYQTKSSIREMESYSQA 147
+ +G ++++ +C A P+ I V+P I+ SV + T +R ++S +++
Sbjct: 1104 TCFLGIISTLVMICMATPV------FTIIVIPLGIIYVSVQMFYVSTSRQLRRLDSVTRS 1157
Query: 148 G--KQAEEVLKSVKTVVAFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYS 205
E + + + AF + QR+ E I +++ +F+ + + W L
Sbjct: 1158 PIYSHFSETVSGLPVIRAFEHQ----QRFLKHNE-VRIDTNQKCVFSWITSN-RW-LAIR 1210
Query: 206 LNTIG----FMYGTRLIIEDANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFA 261
L +G F ++I D +G VLS ++ + +E
Sbjct: 1211 LELVGNLTVFFSALMMVIYRDTLSGDT----VGFVLSNALNITQTLNWLVRMTSEIETNI 1266
Query: 262 TARGAAASIFSLLDKHPKIDCLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLH 321
A + ++ P + P + G+I + Y D+ +L+G +
Sbjct: 1267 VAVERITEYTKVENEAPWVTDKRPPPDWPSK--GKIQFNNYQVRYRPELDL-VLRGITCD 1323
Query: 322 IKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQE 381
I E + +VG +G GKS++ L R+ + G + +DG ++ ++ + LR L ++ Q+
Sbjct: 1324 IGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQD 1383
Query: 382 PVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQK 441
P+LF G++ N+ + + E++++ E+A+ F+ +L G + E G +LS GQ+
Sbjct: 1384 PILFSGSLRMNLD-PFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQR 1442
Query: 442 QRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCH 501
Q + + R+LLR+ +L+LDEAT+A+D ++ +Q + T +T++HRL TI++
Sbjct: 1443 QLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSD 1502
Query: 502 RIICMDQGTIIEQGTHVELMKAKG-FYHKLVTSGKE 536
+++ +D G IIE G+ EL++ G FY +G E
Sbjct: 1503 KVMVLDNGKIIECGSPEELLQIPGPFYFMAKEAGIE 1538
Score = 143 bits (347), Expect = 3e-33
Identities = 78/250 (31%), Positives = 134/250 (53%), Gaps = 5/250 (2%)
Query: 899 DWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFY 958
DW + G N+ + Y ++L+GI + + + + +VG +G GKS++ + R
Sbjct: 1293 DWPSKGKIQFNNYQVRYRPEL-DLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRIL 1351
Query: 959 DPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXX 1018
+ G I +DGVDI S+ L+ LR++L ++ Q+PILF +L N+ D + +E
Sbjct: 1352 EAAGGQIIIDGVDIA-SIGLHDLREKLTIIPQDPILFSGSLRMNL---DPFNNYSDEEIW 1407
Query: 1019 XXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSAL 1078
+F+ SL G +Q +C+ RAL+R ++L+LDEAT+A+
Sbjct: 1408 KALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAV 1467
Query: 1079 DANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGH 1138
D ++ + + + T ITIAHRL TI D+D + VLD GKI+E G+ EL+ + G
Sbjct: 1468 DLETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGP 1527
Query: 1139 YWQLSKQQNV 1148
++ ++K+ +
Sbjct: 1528 FYFMAKEAGI 1537
Score = 101 bits (243), Expect = 1e-20
Identities = 73/262 (27%), Positives = 126/262 (48%), Gaps = 18/262 (6%)
Query: 297 ISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSV 356
+ + F++ S+ + + +L I G+ VA++G G GKS+++ + + G +
Sbjct: 637 MQFSEASFTWEHDSEATV-RDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHI 695
Query: 357 KLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHE 416
+ G W+++ GTI DNI G E + +V E
Sbjct: 696 TIKGTTAYVPQQSWIQN-------------GTIKDNILFG-TEFNEKRYQQVLEACALLP 741
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-Q 475
++ LP G IGE+G +LSGGQKQRI++AR+ + + LLD+ SA+D H K +
Sbjct: 742 DLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFN 801
Query: 476 AALDRASV--GRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTS 533
L + G+T L V+H + + I+ + GTI+E+G++ L+ KG + K + +
Sbjct: 802 KVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLKT 861
Query: 534 GKETKEPEEIGTVLEEQETKQN 555
PEE TV + E + +
Sbjct: 862 FLRHTGPEEEATVHDGSEEEDD 883
Score = 66.5 bits (155), Expect = 5e-10
Identities = 52/219 (23%), Positives = 98/219 (44%), Gaps = 20/219 (9%)
Query: 924 LKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRK 983
++ ++L + AG+ VA++G G GKS+++ + + G+I + G
Sbjct: 654 VRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTT------------ 701
Query: 984 QLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXX 1043
V Q+ + + T+ +NI +G + + + LP G
Sbjct: 702 --AYVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEACALLPD---LEMLPGGDLAEIGE 756
Query: 1044 XXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEAL---DHAAKGRTCI 1100
KQR+ +ARA ++ + LLD+ SA+DA+ + + + + KG+T +
Sbjct: 757 KGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRL 816
Query: 1101 TIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHY 1139
+ H + + D I VL G IVEKG+++ L+ KG +
Sbjct: 817 LVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEF 855
>AL133353-7|CAI14502.1| 1545|Homo sapiens ATP-binding cassette,
sub-family C (CFTR/MRP), member 2 protein.
Length = 1545
Score = 152 bits (369), Expect = 6e-36
Identities = 122/516 (23%), Positives = 245/516 (47%), Gaps = 35/516 (6%)
Query: 35 WSALKQI---TTIRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKL-AVV 90
WSA + + K L +LR M +FDT + ++ + ++ + + + + L + +
Sbjct: 1044 WSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRIVNRFAGDISTVDDTLPQSLRSWI 1103
Query: 91 SNLVG--TSIICLCTAFPLGWKLALACITVMPFSIM-ASVALTNYQTKSSIREMESYSQA 147
+ +G ++++ +C A P+ I V+P I+ SV + T +R ++S +++
Sbjct: 1104 TCFLGIISTLVMICMATPV------FTIIVIPLGIIYVSVQMFYVSTSRQLRRLDSVTRS 1157
Query: 148 G--KQAEEVLKSVKTVVAFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYS 205
E + + + AF + QR+ E I +++ +F+ + + W L
Sbjct: 1158 PIYSHFSETVSGLPVIRAFEHQ----QRFLKHNE-VRIDTNQKCVFSWITSN-RW-LAIR 1210
Query: 206 LNTIG----FMYGTRLIIEDANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFA 261
L +G F ++I D +G VLS ++ + +E
Sbjct: 1211 LELVGNLTVFFSALMMVIYRDTLSGDT----VGFVLSNALNITQTLNWLVRMTSEIETNI 1266
Query: 262 TARGAAASIFSLLDKHPKIDCLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLH 321
A + ++ P + P + G+I + Y D+ +L+G +
Sbjct: 1267 VAVERITEYTKVENEAPWVTDKRPPPDWPSK--GKIQFNNYQVRYRPELDL-VLRGITCD 1323
Query: 322 IKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQE 381
I E + +VG +G GKS++ L R+ + G + +DG ++ ++ + LR L ++ Q+
Sbjct: 1324 IGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQD 1383
Query: 382 PVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQK 441
P+LF G++ N+ + + E++++ E+A+ F+ +L G + E G +LS GQ+
Sbjct: 1384 PILFSGSLRMNLD-PFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQR 1442
Query: 442 QRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCH 501
Q + + R+LLR+ +L+LDEAT+A+D ++ +Q + T +T++HRL TI++
Sbjct: 1443 QLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSD 1502
Query: 502 RIICMDQGTIIEQGTHVELMKAKG-FYHKLVTSGKE 536
+++ +D G IIE G+ EL++ G FY +G E
Sbjct: 1503 KVMVLDNGKIIECGSPEELLQIPGPFYFMAKEAGIE 1538
Score = 143 bits (347), Expect = 3e-33
Identities = 78/250 (31%), Positives = 134/250 (53%), Gaps = 5/250 (2%)
Query: 899 DWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFY 958
DW + G N+ + Y ++L+GI + + + + +VG +G GKS++ + R
Sbjct: 1293 DWPSKGKIQFNNYQVRYRPEL-DLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRIL 1351
Query: 959 DPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXX 1018
+ G I +DGVDI S+ L+ LR++L ++ Q+PILF +L N+ D + +E
Sbjct: 1352 EAAGGQIIIDGVDIA-SIGLHDLREKLTIIPQDPILFSGSLRMNL---DPFNNYSDEEIW 1407
Query: 1019 XXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSAL 1078
+F+ SL G +Q +C+ RAL+R ++L+LDEAT+A+
Sbjct: 1408 KALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAV 1467
Query: 1079 DANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGH 1138
D ++ + + + T ITIAHRL TI D+D + VLD GKI+E G+ EL+ + G
Sbjct: 1468 DLETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGP 1527
Query: 1139 YWQLSKQQNV 1148
++ ++K+ +
Sbjct: 1528 FYFMAKEAGI 1537
Score = 101 bits (243), Expect = 1e-20
Identities = 73/262 (27%), Positives = 126/262 (48%), Gaps = 18/262 (6%)
Query: 297 ISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSV 356
+ + F++ S+ + + +L I G+ VA++G G GKS+++ + + G +
Sbjct: 637 MQFSEASFTWEHDSEATV-RDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHI 695
Query: 357 KLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHE 416
+ G W+++ GTI DNI G E + +V E
Sbjct: 696 TIKGTTAYVPQQSWIQN-------------GTIKDNILFG-TEFNEKRYQQVLEACALLP 741
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-Q 475
++ LP G IGE+G +LSGGQKQRI++AR+ + + LLD+ SA+D H K +
Sbjct: 742 DLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFN 801
Query: 476 AALDRASV--GRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTS 533
L + G+T L V+H + + I+ + GTI+E+G++ L+ KG + K + +
Sbjct: 802 KVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLKT 861
Query: 534 GKETKEPEEIGTVLEEQETKQN 555
PEE TV + E + +
Sbjct: 862 FLRHTGPEEEATVHDGSEEEDD 883
Score = 66.5 bits (155), Expect = 5e-10
Identities = 52/219 (23%), Positives = 98/219 (44%), Gaps = 20/219 (9%)
Query: 924 LKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRK 983
++ ++L + AG+ VA++G G GKS+++ + + G+I + G
Sbjct: 654 VRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTT------------ 701
Query: 984 QLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXX 1043
V Q+ + + T+ +NI +G + + + LP G
Sbjct: 702 --AYVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEACALLPD---LEMLPGGDLAEIGE 756
Query: 1044 XXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEAL---DHAAKGRTCI 1100
KQR+ +ARA ++ + LLD+ SA+DA+ + + + + KG+T +
Sbjct: 757 KGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRL 816
Query: 1101 TIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHY 1139
+ H + + D I VL G IVEKG+++ L+ KG +
Sbjct: 817 LVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEF 855
>AY040220-1|AAK76740.1| 1359|Homo sapiens ATP-binding cassette
transporter sub-family C member 12 protein.
Length = 1359
Score = 151 bits (365), Expect = 2e-35
Identities = 76/219 (34%), Positives = 133/219 (60%), Gaps = 2/219 (0%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
GEI+ D Y + + +L +L+I+ G++V +VG +G GKS++ L RL +P G
Sbjct: 1118 GEITFRDYQMRYRDNTPL-VLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPASG 1176
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
++ +D ++ L++ LR+ L V+ Q+PVLF GT+ N+ + T E +++V E +
Sbjct: 1177 TIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLD-PFESHTDEMLWQVLERTFM 1235
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
+ I LP + + E G + S G++Q + +AR+LLR ++LLDEAT+++D ++ V
Sbjct: 1236 RDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATASMDSKTDTLV 1295
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIE 513
Q + A G T LT++HRL+T++NC ++ M+ G +IE
Sbjct: 1296 QNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIE 1334
Score = 138 bits (333), Expect = 1e-31
Identities = 72/228 (31%), Positives = 128/228 (56%), Gaps = 5/228 (2%)
Query: 898 QDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRF 957
+DW + G + D + Y ++L ++L++++G+TV +VG +G GKS++ + R
Sbjct: 1112 KDWPSCGEITFRDYQMRYRDNT-PLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFRL 1170
Query: 958 YDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEX 1017
+P +G I +D VDI L+L LR +L V+ Q+P+LF T+ N+ D T +
Sbjct: 1171 VEPASGTIFIDEVDIC-ILSLEDLRTKLTVIPQDPVLFVGTVRYNL---DPFESHTDEML 1226
Query: 1018 XXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSA 1077
+ I+ LP+ + +Q +C+ARAL+R+ +++LLDEAT++
Sbjct: 1227 WQVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATAS 1286
Query: 1078 LDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVE 1125
+D+ ++ V + A KG T +TIAHRL T+ + D + V++ GK++E
Sbjct: 1287 MDSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIE 1334
Score = 124 bits (300), Expect = 1e-27
Identities = 77/235 (32%), Positives = 128/235 (54%), Gaps = 21/235 (8%)
Query: 314 ILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRS 373
+L S ++ G+ + + G+ G GKS++L L +G V ++G
Sbjct: 495 VLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNG------------- 541
Query: 374 SLGVVGQEPVLFRGTIYDNIAIG--YPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGE 431
+L V Q+ +F G + +NI G Y + RV + + + NLP G T IGE
Sbjct: 542 TLAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGL---QKDLSNLPYGDLTEIGE 598
Query: 432 RGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-QAALDRASVGRTTLTV 490
RG +LSGGQ+QRI++AR++ + + LLD+ SA+D H K V + + + G+T + V
Sbjct: 599 RGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLV 658
Query: 491 SHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTS--GKETKEPEEI 543
+H+L + +C +I ++ G I E+GTH ELM+ +G Y KL+ + G + K+PE +
Sbjct: 659 THQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDPEHL 713
Score = 78.6 bits (185), Expect = 1e-13
Identities = 58/221 (26%), Positives = 99/221 (44%), Gaps = 18/221 (8%)
Query: 923 ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLR 982
+L I V GK + + G+ G GKS++L + G + ++G
Sbjct: 495 VLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGT------------ 542
Query: 983 KQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXX 1042
L V Q+ +F + ENI +G+ K + +LP G T
Sbjct: 543 --LAYVSQQAWIFHGNVRENILFGE---KYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIG 597
Query: 1043 XXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAV-TEALDHAAKGRTCIT 1101
+QR+ +ARA+ +L LLD+ SA+DA+ + V E + +G+T +
Sbjct: 598 ERGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVL 657
Query: 1102 IAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQL 1142
+ H+L ++ D + +L+ G+I EKG H EL+ +G Y +L
Sbjct: 658 VTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKL 698
>U83661-1|AAB71758.2| 1437|Homo sapiens multidrug resistance protein 5
protein.
Length = 1437
Score = 149 bits (362), Expect = 4e-35
Identities = 78/222 (35%), Positives = 128/222 (57%), Gaps = 2/222 (0%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
GE++ E+ Y + +LK S IKP E + +VG +G GKS++ L RL + + G
Sbjct: 1191 GEVTFENAEMRYRENLPL-VLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGG 1249
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+K+DG + + + LRS L ++ QEPVLF GT+ N+ + + T + ++ E +
Sbjct: 1250 CIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLD-PFNQYTEDQIWDALERTHM 1308
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
E I LP E+ + E G + S G++Q + IAR+LLR +L+LDEAT+A+D ++ +
Sbjct: 1309 KECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLI 1368
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGT 516
Q + A T LT++HRL T++ RI+ + QG ++E T
Sbjct: 1369 QETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDT 1410
Score = 123 bits (297), Expect = 3e-27
Identities = 110/457 (24%), Positives = 196/457 (42%), Gaps = 21/457 (4%)
Query: 677 ESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSV--TVGFIMAMSYNWKLTLVSTTF 734
++ G + R S D EV + + +Q V VG I + + W L V
Sbjct: 964 DTTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGV-FPWFLVAVGPLV 1022
Query: 735 LPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFITRFQDAL 794
+ V I ++ + + D + I T ++ + T+ + F+ R+Q+ L
Sbjct: 1023 ILFSVLHIVSRVLIRELKRLDNITQSPFLSHI-TSSIQGLATIHAYNKGQEFLHRYQELL 1081
Query: 795 IDACAAVVKKS---RWRGLVLGLCIYVPLLSYCSAVI---YGAVLVAHGXXXXXXXXXXX 848
D A + RW + L L I + L++ +I +G + A+
Sbjct: 1082 DDNQAPFFLFTCAMRWLAVRLDL-ISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLT 1140
Query: 849 XXXMYGAYMLGQSLVYAPSFNSAKTCGARILSIINREPRIRTVDGLNDKQDWSASGNFSI 908
+ + ++ F S + I ++ P + DW G +
Sbjct: 1141 GLFQFTVRLASET---EARFTSVERINHYIKTLSLEAPA--RIKNKAPSPDWPQEGEVTF 1195
Query: 909 NDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELD 968
+ E Y ++LK + ++ + + +VG +G GKS++ + R + + G I++D
Sbjct: 1196 ENAEMRYRENL-PLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKID 1254
Query: 969 GVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHN 1028
GV I+ + L LR +L ++ QEP+LF T+ N+ D + T D+
Sbjct: 1255 GVRIS-DIGLADLRSKLSIIPQEPVLFSGTVRSNL---DPFNQYTEDQIWDALERTHMKE 1310
Query: 1029 FIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTE 1088
I LP E+ +Q +CIARAL+R ++L+LDEAT+A+D ++ + E
Sbjct: 1311 CIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQE 1370
Query: 1089 ALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVE 1125
+ A T +TIAHRL T+ +D I VL +G++VE
Sbjct: 1371 TIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVE 1407
Score = 118 bits (283), Expect = 2e-25
Identities = 84/283 (29%), Positives = 139/283 (49%), Gaps = 22/283 (7%)
Query: 313 KILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLR 372
+ L L I+ G+ V + GS G GK++++ + +GS+ + G
Sbjct: 576 RTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISG------------ 623
Query: 373 SSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGER 432
+ V Q+ + T+ DNI G E E V + LP+ T IGER
Sbjct: 624 -TFAYVAQQAWILNATLRDNILFG-KEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGER 681
Query: 433 GASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-QAALDRASVGRTTLTVS 491
GA+LSGGQ+QRI++AR+L + ++ +LD+ SALD H + +A+ + +T L V+
Sbjct: 682 GANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVT 741
Query: 492 HRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTS--GKETKEPEEIGTVLE- 548
H+L +V+C +I M +G I E+GTH ELM G Y + + ET P EI + E
Sbjct: 742 HQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLLGET-PPVEINSKKET 800
Query: 549 ---EQETKQNGELQPAVRPEPDVKRRSVRKLHRRQSAKGAHEW 588
+++++ G +V+ E VK + + + +G+ W
Sbjct: 801 SGSQKKSQDKGPKTGSVKKEKAVKPEEGQLVQLEEKGQGSVPW 843
Score = 77.4 bits (182), Expect = 3e-13
Identities = 57/220 (25%), Positives = 93/220 (42%), Gaps = 18/220 (8%)
Query: 921 QMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNR 980
Q L IDL ++ GK V + GS G GK++++ I G+I + G
Sbjct: 575 QRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGT---------- 624
Query: 981 LRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETN 1040
V Q+ + + TL +NI +G ++ + + LP T
Sbjct: 625 ----FAYVAQQAWILNATLRDNILFG---KEYDEERYNSVLNSCCLRPDLAILPSSDLTE 677
Query: 1041 XXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDAN-SERAVTEALDHAAKGRTC 1099
+QR+ +ARAL + +LD+ SALDA+ A+ K +T
Sbjct: 678 IGERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTV 737
Query: 1100 ITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHY 1139
+ + H+L + D D + + +G I E+G H EL+ L G Y
Sbjct: 738 LFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDY 777
>L78243-2|AAB02418.1| 1582|Homo sapiens SUR1 protein.
Length = 1582
Score = 149 bits (362), Expect = 4e-35
Identities = 125/511 (24%), Positives = 244/511 (47%), Gaps = 26/511 (5%)
Query: 23 ILCNVLSVALVSWSALKQITTIRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEG 82
+LC V SV V W+ LK + + L ++ M +F+T ++ ++ S + + +
Sbjct: 1077 VLCLVTSVT-VEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQH 1135
Query: 83 MGEKLAVVSNLVGTSIICLCTAFPLGWKLALACITVMPFSIMASVALTNYQTKS-SIREM 141
+ L +S ++++C+ + + + + ++P +I+ ++ S ++++
Sbjct: 1136 IPSTLECLSR---STLLCVSALAVISYVTPVFLVALLPLAIVCYFIQKYFRVASRDLQQL 1192
Query: 142 ESYSQAGKQAE--EVLKSVKTVVAFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFN 199
+ +Q + E ++ + T+ AF E + + LLE + S + LF N
Sbjct: 1193 DDTTQLPLLSHFAETVEGLTTIRAF---RYEARFQQKLLEYTD-SNNIASLFLTAAN--R 1246
Query: 200 WVLTYSLNTIGFMYGTRLIIEDANKPDDERTYIIGIV-LSITFSVYMATQSITLCVPHME 258
W L + IG + + R G+V L +T+++ M + + V ++
Sbjct: 1247 W-LEVRMEYIGACVVLIAAVTSISN-SLHRELSAGLVGLGLTYAL-MVSNYLNWMVRNLA 1303
Query: 259 VFATARGAAASIFSLLDKHPK-IDCLSEAGSSPRRVI--GEISLEDVHFSYPSRSDIKIL 315
GA I LL + + L P+ G+I ++++ Y S S +L
Sbjct: 1304 DMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDS-SLKPVL 1362
Query: 316 KGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSL 375
K + I PG+ + + G +G GKS+ R+ D +G + +DG ++ L + LRS L
Sbjct: 1363 KHVNALISPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRL 1422
Query: 376 GVVGQEPVLFRGTIYDNIAIGYPEATSED--VYRVAEMAYAHEFIKNLPNGYETVIGERG 433
++ Q+PVLF GTI N+ PE D ++ E+A +K LP G + +I E G
Sbjct: 1423 SIILQDPVLFSGTIRFNLD---PERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGG 1479
Query: 434 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVSHR 493
+ S GQ+Q +AR+ +R+ ++ ++DEAT+++D +E +Q + A RT +T++HR
Sbjct: 1480 ENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHR 1539
Query: 494 LSTIVNCHRIICMDQGTIIEQGTHVELMKAK 524
+ TI++ +I + +G I+E +L+ K
Sbjct: 1540 VHTILSADLVIVLKRGAILEFDKPEKLLSRK 1570
Score = 119 bits (287), Expect = 5e-26
Identities = 69/239 (28%), Positives = 120/239 (50%), Gaps = 5/239 (2%)
Query: 898 QDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRF 957
++W G I ++ Y + + +LK ++ + G+ + + G +G GKS+ R
Sbjct: 1337 KNWPDQGKIQIQNLSVRYDSSL-KPVLKHVNALISPGQKIGICGRTGSGKSSFSLAFFRM 1395
Query: 958 YDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEX 1017
D G+I +DG+DI K L L+ LR +L ++ Q+P+LF T+ N+ D RK +
Sbjct: 1396 VDTFEGHIIIDGIDIAK-LPLHTLRSRLSIILQDPVLFSGTIRFNL---DPERKCSDSTL 1451
Query: 1018 XXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSA 1077
+ +LP G + +Q C+ARA +R + ++DEAT++
Sbjct: 1452 WEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATAS 1511
Query: 1078 LDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLK 1136
+D +E + + + A RT +TIAHR+ TI AD++ VL +G I+E +L+ K
Sbjct: 1512 IDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRK 1570
Score = 93.9 bits (223), Expect = 3e-18
Identities = 83/262 (31%), Positives = 126/262 (48%), Gaps = 23/262 (8%)
Query: 312 IKILKGFSLHIKPGESVALVGSSGCGKSTILQL----LQR----------LYDPNQGSVK 357
I L ++ I G+ +VG GCGKS++L +Q+ L D G
Sbjct: 693 IPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSSLPDSEIGEDP 752
Query: 358 LDGRNLKT-LNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHE 416
R T L+I R + Q+P L T+ +NI P + V E
Sbjct: 753 SPERETATDLDIR-KRGPVAYASQKPWLLNATVEENIIFESP-FNKQRYKMVIEACSLQP 810
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPH-SEKQVQ 475
I LP+G +T IGERG +LSGGQ+QRI++AR+L + V+ LD+ SALD H S+ +Q
Sbjct: 811 DIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLMQ 870
Query: 476 AALDR--ASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKG--FYHKLV 531
A + RT + V+H+L + + II M GTI +GT + +++ F H
Sbjct: 871 AGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKT 930
Query: 532 TSGKETKEPEEIGTVLEEQETK 553
++ +E E+ TV E + T+
Sbjct: 931 LMNRQDQELEK-ETVTERKATE 951
Score = 53.6 bits (123), Expect = 4e-06
Identities = 54/220 (24%), Positives = 94/220 (42%), Gaps = 19/220 (8%)
Query: 924 LKGIDLHVEAGKTVALVGSSGCGKSTVLQL----IQR-----FYDPTTGNIEL--DGVDI 972
L I + + G+ +VG GCGKS++L +Q+ F+ + + E+ D
Sbjct: 696 LSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSSLPDSEIGEDPSPE 755
Query: 973 TKSLTLNRLRKQ--LGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFI 1030
++ T +RK+ + Q+P L + T+ ENI + K I
Sbjct: 756 RETATDLDIRKRGPVAYASQKPWLLNATVEENIIFESPFNK---QRYKMVIEACSLQPDI 812
Query: 1031 VSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDAN-SERAVTEA 1089
LP G +T +QR+ +ARAL + ++ LD+ SALD + S+ +
Sbjct: 813 DILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLMQAG 872
Query: 1090 LDHAAKG--RTCITIAHRLTTIKDADIICVLDKGKIVEKG 1127
+ + RT + + H+L + AD I + G I +G
Sbjct: 873 ILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREG 912
>L78243-1|AAB02417.1| 1581|Homo sapiens SUR1 protein.
Length = 1581
Score = 149 bits (362), Expect = 4e-35
Identities = 125/511 (24%), Positives = 244/511 (47%), Gaps = 26/511 (5%)
Query: 23 ILCNVLSVALVSWSALKQITTIRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEG 82
+LC V SV V W+ LK + + L ++ M +F+T ++ ++ S + + +
Sbjct: 1076 VLCLVTSVT-VEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQH 1134
Query: 83 MGEKLAVVSNLVGTSIICLCTAFPLGWKLALACITVMPFSIMASVALTNYQTKS-SIREM 141
+ L +S ++++C+ + + + + ++P +I+ ++ S ++++
Sbjct: 1135 IPSTLECLSR---STLLCVSALAVISYVTPVFLVALLPLAIVCYFIQKYFRVASRDLQQL 1191
Query: 142 ESYSQAGKQAE--EVLKSVKTVVAFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFN 199
+ +Q + E ++ + T+ AF E + + LLE + S + LF N
Sbjct: 1192 DDTTQLPLLSHFAETVEGLTTIRAF---RYEARFQQKLLEYTD-SNNIASLFLTAAN--R 1245
Query: 200 WVLTYSLNTIGFMYGTRLIIEDANKPDDERTYIIGIV-LSITFSVYMATQSITLCVPHME 258
W L + IG + + R G+V L +T+++ M + + V ++
Sbjct: 1246 W-LEVRMEYIGACVVLIAAVTSISN-SLHRELSAGLVGLGLTYAL-MVSNYLNWMVRNLA 1302
Query: 259 VFATARGAAASIFSLLDKHPK-IDCLSEAGSSPRRVI--GEISLEDVHFSYPSRSDIKIL 315
GA I LL + + L P+ G+I ++++ Y S S +L
Sbjct: 1303 DMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDS-SLKPVL 1361
Query: 316 KGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSL 375
K + I PG+ + + G +G GKS+ R+ D +G + +DG ++ L + LRS L
Sbjct: 1362 KHVNALISPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRL 1421
Query: 376 GVVGQEPVLFRGTIYDNIAIGYPEATSED--VYRVAEMAYAHEFIKNLPNGYETVIGERG 433
++ Q+PVLF GTI N+ PE D ++ E+A +K LP G + +I E G
Sbjct: 1422 SIILQDPVLFSGTIRFNLD---PERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGG 1478
Query: 434 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVSHR 493
+ S GQ+Q +AR+ +R+ ++ ++DEAT+++D +E +Q + A RT +T++HR
Sbjct: 1479 ENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHR 1538
Query: 494 LSTIVNCHRIICMDQGTIIEQGTHVELMKAK 524
+ TI++ +I + +G I+E +L+ K
Sbjct: 1539 VHTILSADLVIVLKRGAILEFDKPEKLLSRK 1569
Score = 119 bits (287), Expect = 5e-26
Identities = 69/239 (28%), Positives = 120/239 (50%), Gaps = 5/239 (2%)
Query: 898 QDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRF 957
++W G I ++ Y + + +LK ++ + G+ + + G +G GKS+ R
Sbjct: 1336 KNWPDQGKIQIQNLSVRYDSSL-KPVLKHVNALISPGQKIGICGRTGSGKSSFSLAFFRM 1394
Query: 958 YDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEX 1017
D G+I +DG+DI K L L+ LR +L ++ Q+P+LF T+ N+ D RK +
Sbjct: 1395 VDTFEGHIIIDGIDIAK-LPLHTLRSRLSIILQDPVLFSGTIRFNL---DPERKCSDSTL 1450
Query: 1018 XXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSA 1077
+ +LP G + +Q C+ARA +R + ++DEAT++
Sbjct: 1451 WEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATAS 1510
Query: 1078 LDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLK 1136
+D +E + + + A RT +TIAHR+ TI AD++ VL +G I+E +L+ K
Sbjct: 1511 IDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRK 1569
Score = 94.7 bits (225), Expect = 2e-18
Identities = 83/261 (31%), Positives = 126/261 (48%), Gaps = 22/261 (8%)
Query: 312 IKILKGFSLHIKPGESVALVGSSGCGKSTILQL----LQR---------LYDPNQGSVKL 358
I L ++ I G+ +VG GCGKS++L +Q+ L D G
Sbjct: 693 IPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPS 752
Query: 359 DGRNLKT-LNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEF 417
R T L+I R + Q+P L T+ +NI P + V E
Sbjct: 753 PERETATDLDIR-KRGPVAYASQKPWLLNATVEENIIFESP-FNKQRYKMVIEACSLQPD 810
Query: 418 IKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPH-SEKQVQA 476
I LP+G +T IGERG +LSGGQ+QRI++AR+L + V+ LD+ SALD H S+ +QA
Sbjct: 811 IDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLMQA 870
Query: 477 ALDR--ASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKG--FYHKLVT 532
+ RT + V+H+L + + II M GTI +GT + +++ F H
Sbjct: 871 GILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKTL 930
Query: 533 SGKETKEPEEIGTVLEEQETK 553
++ +E E+ TV E + T+
Sbjct: 931 MNRQDQELEK-ETVTERKATE 950
Score = 54.0 bits (124), Expect = 3e-06
Identities = 53/219 (24%), Positives = 90/219 (41%), Gaps = 18/219 (8%)
Query: 924 LKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNI---ELDGVDITKSLTLNR 980
L I + + G+ +VG GCGKS++L +G + L +I + + R
Sbjct: 696 LSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPSPER 755
Query: 981 -------LRKQ--LGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIV 1031
+RK+ + Q+P L + T+ ENI + K I
Sbjct: 756 ETATDLDIRKRGPVAYASQKPWLLNATVEENIIFESPFNK---QRYKMVIEACSLQPDID 812
Query: 1032 SLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDAN-SERAVTEAL 1090
LP G +T +QR+ +ARAL + ++ LD+ SALD + S+ + +
Sbjct: 813 ILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLMQAGI 872
Query: 1091 DHAAKG--RTCITIAHRLTTIKDADIICVLDKGKIVEKG 1127
+ RT + + H+L + AD I + G I +G
Sbjct: 873 LELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREG 911
>L78207-1|AAB02278.1| 1581|Homo sapiens sulfonylurea receptor protein.
Length = 1581
Score = 149 bits (362), Expect = 4e-35
Identities = 125/511 (24%), Positives = 244/511 (47%), Gaps = 26/511 (5%)
Query: 23 ILCNVLSVALVSWSALKQITTIRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEG 82
+LC V SV V W+ LK + + L ++ M +F+T ++ ++ S + + +
Sbjct: 1076 VLCLVTSVT-VEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQH 1134
Query: 83 MGEKLAVVSNLVGTSIICLCTAFPLGWKLALACITVMPFSIMASVALTNYQTKS-SIREM 141
+ L +S ++++C+ + + + + ++P +I+ ++ S ++++
Sbjct: 1135 IPSTLECLSR---STLLCVSALAVISYVTPVFLVALLPLAIVCYFIQKYFRVASRDLQQL 1191
Query: 142 ESYSQAGKQAE--EVLKSVKTVVAFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFN 199
+ +Q + E ++ + T+ AF E + + LLE + S + LF N
Sbjct: 1192 DDTTQLPLLSHFAETVEGLTTIRAF---RYEARFQQKLLEYTD-SNNIASLFLTAAN--R 1245
Query: 200 WVLTYSLNTIGFMYGTRLIIEDANKPDDERTYIIGIV-LSITFSVYMATQSITLCVPHME 258
W L + IG + + R G+V L +T+++ M + + V ++
Sbjct: 1246 W-LEVRMEYIGACVVLIAAVTSISN-SLHRELSAGLVGLGLTYAL-MVSNYLNWMVRNLA 1302
Query: 259 VFATARGAAASIFSLLDKHPK-IDCLSEAGSSPRRVI--GEISLEDVHFSYPSRSDIKIL 315
GA I LL + + L P+ G+I ++++ Y S S +L
Sbjct: 1303 DMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDS-SLKPVL 1361
Query: 316 KGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSL 375
K + I PG+ + + G +G GKS+ R+ D +G + +DG ++ L + LRS L
Sbjct: 1362 KHVNALISPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRL 1421
Query: 376 GVVGQEPVLFRGTIYDNIAIGYPEATSED--VYRVAEMAYAHEFIKNLPNGYETVIGERG 433
++ Q+PVLF GTI N+ PE D ++ E+A +K LP G + +I E G
Sbjct: 1422 SIILQDPVLFSGTIRFNLD---PERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGG 1478
Query: 434 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVSHR 493
+ S GQ+Q +AR+ +R+ ++ ++DEAT+++D +E +Q + A RT +T++HR
Sbjct: 1479 ENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHR 1538
Query: 494 LSTIVNCHRIICMDQGTIIEQGTHVELMKAK 524
+ TI++ +I + +G I+E +L+ K
Sbjct: 1539 VHTILSADLVIVLKRGAILEFDKPEKLLSRK 1569
Score = 119 bits (287), Expect = 5e-26
Identities = 69/239 (28%), Positives = 120/239 (50%), Gaps = 5/239 (2%)
Query: 898 QDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRF 957
++W G I ++ Y + + +LK ++ + G+ + + G +G GKS+ R
Sbjct: 1336 KNWPDQGKIQIQNLSVRYDSSL-KPVLKHVNALISPGQKIGICGRTGSGKSSFSLAFFRM 1394
Query: 958 YDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEX 1017
D G+I +DG+DI K L L+ LR +L ++ Q+P+LF T+ N+ D RK +
Sbjct: 1395 VDTFEGHIIIDGIDIAK-LPLHTLRSRLSIILQDPVLFSGTIRFNL---DPERKCSDSTL 1450
Query: 1018 XXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSA 1077
+ +LP G + +Q C+ARA +R + ++DEAT++
Sbjct: 1451 WEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATAS 1510
Query: 1078 LDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLK 1136
+D +E + + + A RT +TIAHR+ TI AD++ VL +G I+E +L+ K
Sbjct: 1511 IDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRK 1569
Score = 94.7 bits (225), Expect = 2e-18
Identities = 83/261 (31%), Positives = 126/261 (48%), Gaps = 22/261 (8%)
Query: 312 IKILKGFSLHIKPGESVALVGSSGCGKSTILQL----LQR---------LYDPNQGSVKL 358
I L ++ I G+ +VG GCGKS++L +Q+ L D G
Sbjct: 693 IPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPS 752
Query: 359 DGRNLKT-LNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEF 417
R T L+I R + Q+P L T+ +NI P + V E
Sbjct: 753 PERETATDLDIR-KRGPVAYASQKPWLLNATVEENIIFESP-FNKQRYKMVIEACSLQPD 810
Query: 418 IKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPH-SEKQVQA 476
I LP+G +T IGERG +LSGGQ+QRI++AR+L + V+ LD+ SALD H S+ +QA
Sbjct: 811 IDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLMQA 870
Query: 477 ALDR--ASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKG--FYHKLVT 532
+ RT + V+H+L + + II M GTI +GT + +++ F H
Sbjct: 871 GILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKTL 930
Query: 533 SGKETKEPEEIGTVLEEQETK 553
++ +E E+ TV E + T+
Sbjct: 931 MNRQDQELEK-ETVTERKATE 950
Score = 54.0 bits (124), Expect = 3e-06
Identities = 53/219 (24%), Positives = 90/219 (41%), Gaps = 18/219 (8%)
Query: 924 LKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNI---ELDGVDITKSLTLNR 980
L I + + G+ +VG GCGKS++L +G + L +I + + R
Sbjct: 696 LSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPSPER 755
Query: 981 -------LRKQ--LGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIV 1031
+RK+ + Q+P L + T+ ENI + K I
Sbjct: 756 ETATDLDIRKRGPVAYASQKPWLLNATVEENIIFESPFNK---QRYKMVIEACSLQPDID 812
Query: 1032 SLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDAN-SERAVTEAL 1090
LP G +T +QR+ +ARAL + ++ LD+ SALD + S+ + +
Sbjct: 813 ILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLMQAGI 872
Query: 1091 DHAAKG--RTCITIAHRLTTIKDADIICVLDKGKIVEKG 1127
+ RT + + H+L + AD I + G I +G
Sbjct: 873 LELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREG 911
>AY196484-1|AAO49801.1| 1394|Homo sapiens ATP-binding cassette C5
splicing variant A protein.
Length = 1394
Score = 149 bits (362), Expect = 4e-35
Identities = 78/222 (35%), Positives = 128/222 (57%), Gaps = 2/222 (0%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
GE++ E+ Y + +LK S IKP E + +VG +G GKS++ L RL + + G
Sbjct: 1148 GEVTFENAEMRYRENLPL-VLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGG 1206
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+K+DG + + + LRS L ++ QEPVLF GT+ N+ + + T + ++ E +
Sbjct: 1207 CIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLD-PFNQYTEDQIWDALERTHM 1265
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
E I LP E+ + E G + S G++Q + IAR+LLR +L+LDEAT+A+D ++ +
Sbjct: 1266 KECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLI 1325
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGT 516
Q + A T LT++HRL T++ RI+ + QG ++E T
Sbjct: 1326 QETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDT 1367
Score = 122 bits (293), Expect = 1e-26
Identities = 71/227 (31%), Positives = 118/227 (51%), Gaps = 5/227 (2%)
Query: 899 DWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFY 958
DW G + + E Y ++LK + ++ + + +VG +G GKS++ + R
Sbjct: 1143 DWPQEGEVTFENAEMRYRENL-PLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLV 1201
Query: 959 DPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXX 1018
+ + G I++DGV I+ + L LR +L ++ QEP+LF T+ N+ D + T D+
Sbjct: 1202 ELSGGCIKIDGVRIS-DIGLADLRSKLSIIPQEPVLFSGTVRSNL---DPFNQYTEDQIW 1257
Query: 1019 XXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSAL 1078
I LP E+ +Q +CIARAL+R ++L+LDEAT+A+
Sbjct: 1258 DALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAM 1317
Query: 1079 DANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVE 1125
D ++ + E + A T +TIAHRL T+ +D I VL +G++VE
Sbjct: 1318 DTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVE 1364
Score = 118 bits (283), Expect = 2e-25
Identities = 84/283 (29%), Positives = 139/283 (49%), Gaps = 22/283 (7%)
Query: 313 KILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLR 372
+ L L I+ G+ V + GS G GK++++ + +GS+ + G
Sbjct: 576 RTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISG------------ 623
Query: 373 SSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGER 432
+ V Q+ + T+ DNI G E E V + LP+ T IGER
Sbjct: 624 -TFAYVAQQAWILNATLRDNILFG-KEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGER 681
Query: 433 GASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-QAALDRASVGRTTLTVS 491
GA+LSGGQ+QRI++AR+L + ++ +LD+ SALD H + +A+ + +T L V+
Sbjct: 682 GANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVT 741
Query: 492 HRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTS--GKETKEPEEIGTVLE- 548
H+L +V+C +I M +G I E+GTH ELM G Y + + ET P EI + E
Sbjct: 742 HQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLLGET-PPVEINSKKET 800
Query: 549 ---EQETKQNGELQPAVRPEPDVKRRSVRKLHRRQSAKGAHEW 588
+++++ G +V+ E VK + + + +G+ W
Sbjct: 801 SGSQKKSQDKGPKTGSVKKEKAVKPEEGQLVQLEEKGQGSVPW 843
Score = 77.4 bits (182), Expect = 3e-13
Identities = 57/220 (25%), Positives = 93/220 (42%), Gaps = 18/220 (8%)
Query: 921 QMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNR 980
Q L IDL ++ GK V + GS G GK++++ I G+I + G
Sbjct: 575 QRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGT---------- 624
Query: 981 LRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETN 1040
V Q+ + + TL +NI +G ++ + + LP T
Sbjct: 625 ----FAYVAQQAWILNATLRDNILFG---KEYDEERYNSVLNSCCLRPDLAILPSSDLTE 677
Query: 1041 XXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDAN-SERAVTEALDHAAKGRTC 1099
+QR+ +ARAL + +LD+ SALDA+ A+ K +T
Sbjct: 678 IGERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTV 737
Query: 1100 ITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHY 1139
+ + H+L + D D + + +G I E+G H EL+ L G Y
Sbjct: 738 LFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDY 777
>AL833963-1|CAD38811.1| 453|Homo sapiens hypothetical protein
protein.
Length = 453
Score = 149 bits (362), Expect = 4e-35
Identities = 76/157 (48%), Positives = 100/157 (63%)
Query: 315 LKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSS 374
++ S + PG+ ALVG SG GKS+ + +L+ Y G V LDG+ + + +L
Sbjct: 268 MENVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRV 327
Query: 375 LGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGA 434
+ +V QEPVLF +I DNI+ G P E V A+ A AH FI L +GY T GE+GA
Sbjct: 328 ISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGA 387
Query: 435 SLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSE 471
LSGGQKQR+A+AR+L+R P VL+LDEATSALD SE
Sbjct: 388 QLSGGQKQRVAMARALVRNPPVLILDEATSALDAESE 424
Score = 112 bits (270), Expect = 6e-24
Identities = 63/166 (37%), Positives = 92/166 (55%), Gaps = 7/166 (4%)
Query: 924 LKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRK 983
++ + + GK ALVG SG GKS+ + +++ FY G + LDG I+ + L +
Sbjct: 268 MENVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPIS-AYDHKYLHR 326
Query: 984 QLGVVQQEPILFDRTLAENIAYGDNSRKPTM--DEXXXXXXXXXXHNFIVSLPKGYETNX 1041
+ +V QEP+LF R++ +NI+YG PT+ + H FI+ L GY T
Sbjct: 327 VISLVSQEPVLFARSITDNISYG----LPTVPFEMVVEAAQKANAHGFIMELQDGYSTET 382
Query: 1042 XXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVT 1087
KQRV +ARAL+R+P +L+LDEATSALDA SE V+
Sbjct: 383 GEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLVS 428
Score = 39.1 bits (87), Expect = 0.090
Identities = 21/73 (28%), Positives = 34/73 (46%)
Query: 107 LGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAFGG 166
L W+L+L P +M S Y + S + ++A AEE + ++KTV +F
Sbjct: 133 LSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFAN 192
Query: 167 ENIEVQRYKSLLE 179
E E + Y L+
Sbjct: 193 EEEEAEVYLRKLQ 205
>AJ132244-1|CAB45309.1| 1545|Homo sapiens multidrug resistance protein
2 (MRP2) protein.
Length = 1545
Score = 149 bits (362), Expect = 4e-35
Identities = 122/516 (23%), Positives = 244/516 (47%), Gaps = 35/516 (6%)
Query: 35 WSALKQI---TTIRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKL-AVV 90
WSA + + K L +LR M +FDT + ++ + ++ + + + + L + +
Sbjct: 1044 WSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRIVNRFAGDISTVDDTLPQSLRSWI 1103
Query: 91 SNLVG--TSIICLCTAFPLGWKLALACITVMPFSIM-ASVALTNYQTKSSIREMESYSQA 147
+ +G ++++ +C A P+ I V+P I+ SV + T +R ++S +++
Sbjct: 1104 TCFLGIISTLVMICMATPV------FTIIVIPLGIIYVSVQMFYVSTSRQLRRLDSVTRS 1157
Query: 148 G--KQAEEVLKSVKTVVAFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYS 205
E + + + AF + QR+ E I +++ +F+ + + W L
Sbjct: 1158 PIYSHFSETVSGLPVIRAFEHQ----QRFLKHNE-VRIDTNQKCVFSWITSN-RW-LAIR 1210
Query: 206 LNTIG----FMYGTRLIIEDANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFA 261
L +G F ++I D +G VLS ++ + +E
Sbjct: 1211 LELVGNLTVFFSALMMVIYRDTLSGDT----VGFVLSNALNITQTLNWLVRMTSEIETNI 1266
Query: 262 TARGAAASIFSLLDKHPKIDCLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLH 321
A + ++ P + P + G+I + Y D+ +L+G +
Sbjct: 1267 VAVERITEYTKVENEAPWVTDKRPPPDWPSK--GKIQFNNYQVRYRPELDL-VLRGITCD 1323
Query: 322 IKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQE 381
I E + +VG +G GKS++ L R+ + G + +DG ++ ++ + LR L ++ Q+
Sbjct: 1324 IGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQD 1383
Query: 382 PVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQK 441
P+LF G++ N+ + + E++++ E+A+ F+ +L G E G +LS GQ+
Sbjct: 1384 PILFSGSLRMNLD-PFNNYSDEEIWKALELAHLKSFVASLQLGLSHEGTEAGGNLSIGQR 1442
Query: 442 QRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCH 501
Q + + R+LLR+ +L+LDEAT+A+D ++ +Q + T +T++HRL TI++
Sbjct: 1443 QLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSD 1502
Query: 502 RIICMDQGTIIEQGTHVELMKAKG-FYHKLVTSGKE 536
+++ +D G IIE G+ EL++ G FY +G E
Sbjct: 1503 KVMVLDNGKIIECGSPEELLQIPGPFYFMAKEAGIE 1538
Score = 143 bits (347), Expect = 3e-33
Identities = 78/250 (31%), Positives = 134/250 (53%), Gaps = 5/250 (2%)
Query: 899 DWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFY 958
DW + G N+ + Y ++L+GI + + + + +VG +G GKS++ + R
Sbjct: 1293 DWPSKGKIQFNNYQVRYRPEL-DLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRIL 1351
Query: 959 DPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXX 1018
+ G I +DGVDI S+ L+ LR++L ++ Q+PILF +L N+ D + +E
Sbjct: 1352 EAAGGQIIIDGVDIA-SIGLHDLREKLTIIPQDPILFSGSLRMNL---DPFNNYSDEEIW 1407
Query: 1019 XXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSAL 1078
+F+ SL G +Q +C+ RAL+R ++L+LDEAT+A+
Sbjct: 1408 KALELAHLKSFVASLQLGLSHEGTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAV 1467
Query: 1079 DANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGH 1138
D ++ + + + T ITIAHRL TI D+D + VLD GKI+E G+ EL+ + G
Sbjct: 1468 DLETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGP 1527
Query: 1139 YWQLSKQQNV 1148
++ ++K+ +
Sbjct: 1528 FYFMAKEAGI 1537
Score = 101 bits (243), Expect = 1e-20
Identities = 73/262 (27%), Positives = 126/262 (48%), Gaps = 18/262 (6%)
Query: 297 ISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSV 356
+ + F++ S+ + + +L I G+ VA++G G GKS+++ + + G +
Sbjct: 637 MQFSEASFTWEHDSEATV-RDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHI 695
Query: 357 KLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHE 416
+ G W+++ GTI DNI G E + +V E
Sbjct: 696 TIKGTTAYVPQQSWIQN-------------GTIKDNILFG-TEFNEKRYQQVLEACALLP 741
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-Q 475
++ LP G IGE+G +LSGGQKQRI++AR+ + + LLD+ SA+D H K +
Sbjct: 742 DLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFN 801
Query: 476 AALDRASV--GRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTS 533
L + G+T L V+H + + I+ + GTI+E+G++ L+ KG + K + +
Sbjct: 802 KVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLKT 861
Query: 534 GKETKEPEEIGTVLEEQETKQN 555
PEE TV + E + +
Sbjct: 862 FLRHTGPEEEATVHDGSEEEDD 883
Score = 66.5 bits (155), Expect = 5e-10
Identities = 52/219 (23%), Positives = 98/219 (44%), Gaps = 20/219 (9%)
Query: 924 LKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRK 983
++ ++L + AG+ VA++G G GKS+++ + + G+I + G
Sbjct: 654 VRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTT------------ 701
Query: 984 QLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXX 1043
V Q+ + + T+ +NI +G + + + LP G
Sbjct: 702 --AYVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEACALLPD---LEMLPGGDLAEIGE 756
Query: 1044 XXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEAL---DHAAKGRTCI 1100
KQR+ +ARA ++ + LLD+ SA+DA+ + + + + KG+T +
Sbjct: 757 KGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRL 816
Query: 1101 TIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHY 1139
+ H + + D I VL G IVEKG+++ L+ KG +
Sbjct: 817 LVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEF 855
>AF146074-1|AAD37716.1| 1437|Homo sapiens ABC protein protein.
Length = 1437
Score = 149 bits (362), Expect = 4e-35
Identities = 78/222 (35%), Positives = 128/222 (57%), Gaps = 2/222 (0%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
GE++ E+ Y + +LK S IKP E + +VG +G GKS++ L RL + + G
Sbjct: 1191 GEVTFENAEMRYRENLPL-VLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGG 1249
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+K+DG + + + LRS L ++ QEPVLF GT+ N+ + + T + ++ E +
Sbjct: 1250 CIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLD-PFNQYTEDQIWDALERTHM 1308
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
E I LP E+ + E G + S G++Q + IAR+LLR +L+LDEAT+A+D ++ +
Sbjct: 1309 KECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLI 1368
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGT 516
Q + A T LT++HRL T++ RI+ + QG ++E T
Sbjct: 1369 QETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDT 1410
Score = 123 bits (297), Expect = 3e-27
Identities = 110/457 (24%), Positives = 196/457 (42%), Gaps = 21/457 (4%)
Query: 677 ESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSV--TVGFIMAMSYNWKLTLVSTTF 734
++ G + R S D EV + + +Q V VG I + + W L V
Sbjct: 964 DTTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGV-FPWFLVAVGPLV 1022
Query: 735 LPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFITRFQDAL 794
+ V I ++ + + D + I T ++ + T+ + F+ R+Q+ L
Sbjct: 1023 ILFSVLHIVSRVLIRELKRLDNITQSPFLSHI-TSSIQGLATIHAYNKGQEFLHRYQELL 1081
Query: 795 IDACAAVVKKS---RWRGLVLGLCIYVPLLSYCSAVI---YGAVLVAHGXXXXXXXXXXX 848
D A + RW + L L I + L++ +I +G + A+
Sbjct: 1082 DDNQAPFFLFTCAMRWLAVRLDL-ISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLT 1140
Query: 849 XXXMYGAYMLGQSLVYAPSFNSAKTCGARILSIINREPRIRTVDGLNDKQDWSASGNFSI 908
+ + ++ F S + I ++ P + DW G +
Sbjct: 1141 GLFQFTVRLASET---EARFTSVERINHYIKTLSLEAPA--RIKNKAPSPDWPQEGEVTF 1195
Query: 909 NDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELD 968
+ E Y ++LK + ++ + + +VG +G GKS++ + R + + G I++D
Sbjct: 1196 ENAEMRYRENL-PLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKID 1254
Query: 969 GVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHN 1028
GV I+ + L LR +L ++ QEP+LF T+ N+ D + T D+
Sbjct: 1255 GVRIS-DIGLADLRSKLSIIPQEPVLFSGTVRSNL---DPFNQYTEDQIWDALERTHMKE 1310
Query: 1029 FIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTE 1088
I LP E+ +Q +CIARAL+R ++L+LDEAT+A+D ++ + E
Sbjct: 1311 CIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQE 1370
Query: 1089 ALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVE 1125
+ A T +TIAHRL T+ +D I VL +G++VE
Sbjct: 1371 TIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVE 1407
Score = 117 bits (282), Expect = 2e-25
Identities = 84/283 (29%), Positives = 139/283 (49%), Gaps = 22/283 (7%)
Query: 313 KILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLR 372
+ L L I+ G+ V + GS G GK++++ + +GS+ + G
Sbjct: 576 RTLHSVDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISG------------ 623
Query: 373 SSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGER 432
+ V Q+ + T+ DNI G E E V + LP+ T IGER
Sbjct: 624 -TFAYVAQQAWILNATLRDNILFG-KEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGER 681
Query: 433 GASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-QAALDRASVGRTTLTVS 491
GA+LSGGQ+QRI++AR+L + ++ +LD+ SALD H + +A+ + +T L V+
Sbjct: 682 GANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVT 741
Query: 492 HRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTS--GKETKEPEEIGTVLE- 548
H+L +V+C +I M +G I E+GTH ELM G Y + + ET P EI + E
Sbjct: 742 HQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLLGET-PPVEINSKKET 800
Query: 549 ---EQETKQNGELQPAVRPEPDVKRRSVRKLHRRQSAKGAHEW 588
+++++ G +V+ E VK + + + +G+ W
Sbjct: 801 SGSQKKSQDKGPKTGSVKKEKAVKPEEGQLVQLEEKGQGSVPW 843
Score = 77.0 bits (181), Expect = 4e-13
Identities = 56/220 (25%), Positives = 93/220 (42%), Gaps = 18/220 (8%)
Query: 921 QMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNR 980
Q L +DL ++ GK V + GS G GK++++ I G+I + G
Sbjct: 575 QRTLHSVDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGT---------- 624
Query: 981 LRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETN 1040
V Q+ + + TL +NI +G ++ + + LP T
Sbjct: 625 ----FAYVAQQAWILNATLRDNILFG---KEYDEERYNSVLNSCCLRPDLAILPSSDLTE 677
Query: 1041 XXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDAN-SERAVTEALDHAAKGRTC 1099
+QR+ +ARAL + +LD+ SALDA+ A+ K +T
Sbjct: 678 IGERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTV 737
Query: 1100 ITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHY 1139
+ + H+L + D D + + +G I E+G H EL+ L G Y
Sbjct: 738 LFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDY 777
>AF104942-1|AAD04169.1| 1437|Homo sapiens ABC transporter MOAT-C
protein.
Length = 1437
Score = 149 bits (362), Expect = 4e-35
Identities = 78/222 (35%), Positives = 128/222 (57%), Gaps = 2/222 (0%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
GE++ E+ Y + +LK S IKP E + +VG +G GKS++ L RL + + G
Sbjct: 1191 GEVTFENAEMRYRENLPL-VLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGG 1249
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+K+DG + + + LRS L ++ QEPVLF GT+ N+ + + T + ++ E +
Sbjct: 1250 CIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLD-PFNQYTEDQIWDALERTHM 1308
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
E I LP E+ + E G + S G++Q + IAR+LLR +L+LDEAT+A+D ++ +
Sbjct: 1309 KECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLI 1368
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGT 516
Q + A T LT++HRL T++ RI+ + QG ++E T
Sbjct: 1369 QETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDT 1410
Score = 123 bits (297), Expect = 3e-27
Identities = 110/457 (24%), Positives = 196/457 (42%), Gaps = 21/457 (4%)
Query: 677 ESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSV--TVGFIMAMSYNWKLTLVSTTF 734
++ G + R S D EV + + +Q V VG I + + W L V
Sbjct: 964 DTTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGV-FPWFLVAVGPLV 1022
Query: 735 LPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFITRFQDAL 794
+ V I ++ + + D + I T ++ + T+ + F+ R+Q+ L
Sbjct: 1023 ILFSVLHIVSRVLIRELKRLDNITQSPFLSHI-TSSIQGLATIHAYNKGQEFLHRYQELL 1081
Query: 795 IDACAAVVKKS---RWRGLVLGLCIYVPLLSYCSAVI---YGAVLVAHGXXXXXXXXXXX 848
D A + RW + L L I + L++ +I +G + A+
Sbjct: 1082 DDNQAPFFLFTCAMRWLAVRLDL-ISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLT 1140
Query: 849 XXXMYGAYMLGQSLVYAPSFNSAKTCGARILSIINREPRIRTVDGLNDKQDWSASGNFSI 908
+ + ++ F S + I ++ P + DW G +
Sbjct: 1141 GLFQFTVRLASET---EARFTSVERINHYIKTLSLEAPA--RIKNKAPSPDWPQEGEVTF 1195
Query: 909 NDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELD 968
+ E Y ++LK + ++ + + +VG +G GKS++ + R + + G I++D
Sbjct: 1196 ENAEMRYRENL-PLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKID 1254
Query: 969 GVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHN 1028
GV I+ + L LR +L ++ QEP+LF T+ N+ D + T D+
Sbjct: 1255 GVRIS-DIGLADLRSKLSIIPQEPVLFSGTVRSNL---DPFNQYTEDQIWDALERTHMKE 1310
Query: 1029 FIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTE 1088
I LP E+ +Q +CIARAL+R ++L+LDEAT+A+D ++ + E
Sbjct: 1311 CIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQE 1370
Query: 1089 ALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVE 1125
+ A T +TIAHRL T+ +D I VL +G++VE
Sbjct: 1371 TIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVE 1407
Score = 118 bits (283), Expect = 2e-25
Identities = 84/283 (29%), Positives = 139/283 (49%), Gaps = 22/283 (7%)
Query: 313 KILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLR 372
+ L L I+ G+ V + GS G GK++++ + +GS+ + G
Sbjct: 576 RTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISG------------ 623
Query: 373 SSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGER 432
+ V Q+ + T+ DNI G E E V + LP+ T IGER
Sbjct: 624 -TFAYVAQQAWILNATLRDNILFG-KEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGER 681
Query: 433 GASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-QAALDRASVGRTTLTVS 491
GA+LSGGQ+QRI++AR+L + ++ +LD+ SALD H + +A+ + +T L V+
Sbjct: 682 GANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVT 741
Query: 492 HRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTS--GKETKEPEEIGTVLE- 548
H+L +V+C +I M +G I E+GTH ELM G Y + + ET P EI + E
Sbjct: 742 HQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLLGET-PPVEINSKKET 800
Query: 549 ---EQETKQNGELQPAVRPEPDVKRRSVRKLHRRQSAKGAHEW 588
+++++ G +V+ E VK + + + +G+ W
Sbjct: 801 SGSQKKSQDKGPKTGSVKKEKAVKPEEGQLVQLEEKGQGSVPW 843
Score = 77.4 bits (182), Expect = 3e-13
Identities = 57/220 (25%), Positives = 93/220 (42%), Gaps = 18/220 (8%)
Query: 921 QMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNR 980
Q L IDL ++ GK V + GS G GK++++ I G+I + G
Sbjct: 575 QRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGT---------- 624
Query: 981 LRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETN 1040
V Q+ + + TL +NI +G ++ + + LP T
Sbjct: 625 ----FAYVAQQAWILNATLRDNILFG---KEYDEERYNSVLNSCCLRPDLAILPSSDLTE 677
Query: 1041 XXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDAN-SERAVTEALDHAAKGRTC 1099
+QR+ +ARAL + +LD+ SALDA+ A+ K +T
Sbjct: 678 IGERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTV 737
Query: 1100 ITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHY 1139
+ + H+L + D D + + +G I E+G H EL+ L G Y
Sbjct: 738 LFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDY 777
>AF087138-1|AAC36724.1| 1581|Homo sapiens sulfonylurea receptor 1
protein.
Length = 1581
Score = 149 bits (362), Expect = 4e-35
Identities = 125/511 (24%), Positives = 244/511 (47%), Gaps = 26/511 (5%)
Query: 23 ILCNVLSVALVSWSALKQITTIRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEG 82
+LC V SV V W+ LK + + L ++ M +F+T ++ ++ S + + +
Sbjct: 1076 VLCLVTSVT-VEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQH 1134
Query: 83 MGEKLAVVSNLVGTSIICLCTAFPLGWKLALACITVMPFSIMASVALTNYQTKS-SIREM 141
+ L +S ++++C+ + + + + ++P +I+ ++ S ++++
Sbjct: 1135 IPSTLECLSR---STLLCVSALAVISYVTPVFLVALLPLAIVCYFIQKYFRVASRDLQQL 1191
Query: 142 ESYSQAGKQAE--EVLKSVKTVVAFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFN 199
+ +Q + E ++ + T+ AF E + + LLE + S + LF N
Sbjct: 1192 DDTTQLPLLSHFAETVEGLTTIRAF---RYEARFQQKLLEYTD-SNNIASLFLTAAN--R 1245
Query: 200 WVLTYSLNTIGFMYGTRLIIEDANKPDDERTYIIGIV-LSITFSVYMATQSITLCVPHME 258
W L + IG + + R G+V L +T+++ M + + V ++
Sbjct: 1246 W-LEVRMEYIGACVVLIAAVTSISN-SLHRELSAGLVGLGLTYAL-MVSNYLNWMVRNLA 1302
Query: 259 VFATARGAAASIFSLLDKHPK-IDCLSEAGSSPRRVI--GEISLEDVHFSYPSRSDIKIL 315
GA I LL + + L P+ G+I ++++ Y S S +L
Sbjct: 1303 DMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDS-SLKPVL 1361
Query: 316 KGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSL 375
K + I PG+ + + G +G GKS+ R+ D +G + +DG ++ L + LRS L
Sbjct: 1362 KHVNALISPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRL 1421
Query: 376 GVVGQEPVLFRGTIYDNIAIGYPEATSED--VYRVAEMAYAHEFIKNLPNGYETVIGERG 433
++ Q+PVLF GTI N+ PE D ++ E+A +K LP G + +I E G
Sbjct: 1422 SIILQDPVLFSGTIRFNLD---PERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGG 1478
Query: 434 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVSHR 493
+ S GQ+Q +AR+ +R+ ++ ++DEAT+++D +E +Q + A RT +T++HR
Sbjct: 1479 ENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHR 1538
Query: 494 LSTIVNCHRIICMDQGTIIEQGTHVELMKAK 524
+ TI++ +I + +G I+E +L+ K
Sbjct: 1539 VHTILSADLVIVLKRGAILEFDKPEKLLSRK 1569
Score = 119 bits (287), Expect = 5e-26
Identities = 69/239 (28%), Positives = 120/239 (50%), Gaps = 5/239 (2%)
Query: 898 QDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRF 957
++W G I ++ Y + + +LK ++ + G+ + + G +G GKS+ R
Sbjct: 1336 KNWPDQGKIQIQNLSVRYDSSL-KPVLKHVNALISPGQKIGICGRTGSGKSSFSLAFFRM 1394
Query: 958 YDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEX 1017
D G+I +DG+DI K L L+ LR +L ++ Q+P+LF T+ N+ D RK +
Sbjct: 1395 VDTFEGHIIIDGIDIAK-LPLHTLRSRLSIILQDPVLFSGTIRFNL---DPERKCSDSTL 1450
Query: 1018 XXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSA 1077
+ +LP G + +Q C+ARA +R + ++DEAT++
Sbjct: 1451 WEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATAS 1510
Query: 1078 LDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLK 1136
+D +E + + + A RT +TIAHR+ TI AD++ VL +G I+E +L+ K
Sbjct: 1511 IDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRK 1569
Score = 94.7 bits (225), Expect = 2e-18
Identities = 83/261 (31%), Positives = 126/261 (48%), Gaps = 22/261 (8%)
Query: 312 IKILKGFSLHIKPGESVALVGSSGCGKSTILQL----LQR---------LYDPNQGSVKL 358
I L ++ I G+ +VG GCGKS++L +Q+ L D G
Sbjct: 693 IPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPS 752
Query: 359 DGRNLKT-LNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEF 417
R T L+I R + Q+P L T+ +NI P + V E
Sbjct: 753 PERETATDLDIR-KRGPVAYASQKPWLLNATVEENIIFESP-FNKQRYKMVIEACSLQPD 810
Query: 418 IKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPH-SEKQVQA 476
I LP+G +T IGERG +LSGGQ+QRI++AR+L + V+ LD+ SALD H S+ +QA
Sbjct: 811 IDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLMQA 870
Query: 477 ALDR--ASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKG--FYHKLVT 532
+ RT + V+H+L + + II M GTI +GT + +++ F H
Sbjct: 871 GILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKTL 930
Query: 533 SGKETKEPEEIGTVLEEQETK 553
++ +E E+ TV E + T+
Sbjct: 931 MNRQDQELEK-ETVTERKATE 950
Score = 54.0 bits (124), Expect = 3e-06
Identities = 53/219 (24%), Positives = 90/219 (41%), Gaps = 18/219 (8%)
Query: 924 LKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNI---ELDGVDITKSLTLNR 980
L I + + G+ +VG GCGKS++L +G + L +I + + R
Sbjct: 696 LSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPSPER 755
Query: 981 -------LRKQ--LGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIV 1031
+RK+ + Q+P L + T+ ENI + K I
Sbjct: 756 ETATDLDIRKRGPVAYASQKPWLLNATVEENIIFESPFNK---QRYKMVIEACSLQPDID 812
Query: 1032 SLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDAN-SERAVTEAL 1090
LP G +T +QR+ +ARAL + ++ LD+ SALD + S+ + +
Sbjct: 813 ILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLMQAGI 872
Query: 1091 DHAAKG--RTCITIAHRLTTIKDADIICVLDKGKIVEKG 1127
+ RT + + H+L + AD I + G I +G
Sbjct: 873 LELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREG 911
>AB209454-1|BAD92691.1| 1430|Homo sapiens Multidrug
resistance-associated protein 5 variant protein.
Length = 1430
Score = 149 bits (362), Expect = 4e-35
Identities = 78/222 (35%), Positives = 128/222 (57%), Gaps = 2/222 (0%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
GE++ E+ Y + +LK S IKP E + +VG +G GKS++ L RL + + G
Sbjct: 1184 GEVTFENAEMRYRENLPL-VLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGG 1242
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+K+DG + + + LRS L ++ QEPVLF GT+ N+ + + T + ++ E +
Sbjct: 1243 CIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLD-PFNQYTEDQIWDALERTHM 1301
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
E I LP E+ + E G + S G++Q + IAR+LLR +L+LDEAT+A+D ++ +
Sbjct: 1302 KECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLI 1361
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGT 516
Q + A T LT++HRL T++ RI+ + QG ++E T
Sbjct: 1362 QETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDT 1403
Score = 123 bits (297), Expect = 3e-27
Identities = 110/457 (24%), Positives = 196/457 (42%), Gaps = 21/457 (4%)
Query: 677 ESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSV--TVGFIMAMSYNWKLTLVSTTF 734
++ G + R S D EV + + +Q V VG I + + W L V
Sbjct: 957 DTTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGV-FPWFLVAVGPLV 1015
Query: 735 LPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFITRFQDAL 794
+ V I ++ + + D + I T ++ + T+ + F+ R+Q+ L
Sbjct: 1016 ILFSVLHIVSRVLIRELKRLDNITQSPFLSHI-TSSIQGLATIHAYNKGQEFLHRYQELL 1074
Query: 795 IDACAAVVKKS---RWRGLVLGLCIYVPLLSYCSAVI---YGAVLVAHGXXXXXXXXXXX 848
D A + RW + L L I + L++ +I +G + A+
Sbjct: 1075 DDNQAPFFLFTCAMRWLAVRLDL-ISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLT 1133
Query: 849 XXXMYGAYMLGQSLVYAPSFNSAKTCGARILSIINREPRIRTVDGLNDKQDWSASGNFSI 908
+ + ++ F S + I ++ P + DW G +
Sbjct: 1134 GLFQFTVRLASET---EARFTSVERINHYIKTLSLEAPA--RIKNKAPSPDWPQEGEVTF 1188
Query: 909 NDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELD 968
+ E Y ++LK + ++ + + +VG +G GKS++ + R + + G I++D
Sbjct: 1189 ENAEMRYRENL-PLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKID 1247
Query: 969 GVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHN 1028
GV I+ + L LR +L ++ QEP+LF T+ N+ D + T D+
Sbjct: 1248 GVRIS-DIGLADLRSKLSIIPQEPVLFSGTVRSNL---DPFNQYTEDQIWDALERTHMKE 1303
Query: 1029 FIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTE 1088
I LP E+ +Q +CIARAL+R ++L+LDEAT+A+D ++ + E
Sbjct: 1304 CIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQE 1363
Query: 1089 ALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVE 1125
+ A T +TIAHRL T+ +D I VL +G++VE
Sbjct: 1364 TIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVE 1400
Score = 118 bits (283), Expect = 2e-25
Identities = 84/283 (29%), Positives = 139/283 (49%), Gaps = 22/283 (7%)
Query: 313 KILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLR 372
+ L L I+ G+ V + GS G GK++++ + +GS+ + G
Sbjct: 569 RTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISG------------ 616
Query: 373 SSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGER 432
+ V Q+ + T+ DNI G E E V + LP+ T IGER
Sbjct: 617 -TFAYVAQQAWILNATLRDNILFG-KEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGER 674
Query: 433 GASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-QAALDRASVGRTTLTVS 491
GA+LSGGQ+QRI++AR+L + ++ +LD+ SALD H + +A+ + +T L V+
Sbjct: 675 GANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVT 734
Query: 492 HRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTS--GKETKEPEEIGTVLE- 548
H+L +V+C +I M +G I E+GTH ELM G Y + + ET P EI + E
Sbjct: 735 HQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLLGET-PPVEINSKKET 793
Query: 549 ---EQETKQNGELQPAVRPEPDVKRRSVRKLHRRQSAKGAHEW 588
+++++ G +V+ E VK + + + +G+ W
Sbjct: 794 SGSQKKSQDKGPKTGSVKKEKAVKPEEGQLVQLEEKGQGSVPW 836
Score = 77.4 bits (182), Expect = 3e-13
Identities = 57/220 (25%), Positives = 93/220 (42%), Gaps = 18/220 (8%)
Query: 921 QMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNR 980
Q L IDL ++ GK V + GS G GK++++ I G+I + G
Sbjct: 568 QRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGT---------- 617
Query: 981 LRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETN 1040
V Q+ + + TL +NI +G ++ + + LP T
Sbjct: 618 ----FAYVAQQAWILNATLRDNILFG---KEYDEERYNSVLNSCCLRPDLAILPSSDLTE 670
Query: 1041 XXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDAN-SERAVTEALDHAAKGRTC 1099
+QR+ +ARAL + +LD+ SALDA+ A+ K +T
Sbjct: 671 IGERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTV 730
Query: 1100 ITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHY 1139
+ + H+L + D D + + +G I E+G H EL+ L G Y
Sbjct: 731 LFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDY 770
>L05628-1|AAB46616.1| 1531|Homo sapiens multidrug
resistance-associated protein protein.
Length = 1531
Score = 148 bits (359), Expect = 1e-34
Identities = 122/489 (24%), Positives = 234/489 (47%), Gaps = 24/489 (4%)
Query: 49 LTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAV----VSNLVGTSIICLCTA 104
L ++LR M++F+ NL ++ S+ L + + E + + + N++G I+ L A
Sbjct: 1053 LHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILL-A 1111
Query: 105 FPLGWKLALACITVMPFSIMASVALTNYQTKS-SIREMESYSQAGKQAE--EVLKSVKTV 161
P+ A I + P ++ Y S ++ +ES S++ + E L V +
Sbjct: 1112 TPI------AAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVI 1165
Query: 162 VAFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIED 221
AF E E ++S L+ E +++ + + W L L +G +
Sbjct: 1166 RAF--EEQERFIHQSDLKVDE---NQKAYYPSIVAN-RW-LAVRLECVGNCIVLFAALFA 1218
Query: 222 ANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKID 281
++G+ +S + V + ME A +S +K
Sbjct: 1219 VISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKE-YSETEKEAPWQ 1277
Query: 282 CLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
A S +G + + Y D +L+ ++ I GE V +VG +G GKS++
Sbjct: 1278 IQETAPPSSWPQVGRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSL 1336
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEAT 401
L R+ + +G + +DG N+ + + LR + ++ Q+PVLF G++ N+ + + +
Sbjct: 1337 TLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD-PFSQYS 1395
Query: 402 SEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 461
E+V+ E+A+ +F+ LP+ + E G +LS GQ+Q + +AR+LLR+ +L+LDE
Sbjct: 1396 DEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDE 1455
Query: 462 ATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELM 521
AT+A+D ++ +Q+ + T LT++HRL+TI++ R+I +D+G I E G +L+
Sbjct: 1456 ATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLL 1515
Query: 522 KAKGFYHKL 530
+ +G ++ +
Sbjct: 1516 QQRGLFYSM 1524
Score = 122 bits (295), Expect = 6e-27
Identities = 68/222 (30%), Positives = 124/222 (55%), Gaps = 4/222 (1%)
Query: 923 ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLR 982
+L+ I++ + G+ V +VG +G GKS++ + R + G I +DG++I K + L+ LR
Sbjct: 1309 VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAK-IGLHDLR 1367
Query: 983 KQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXX 1042
++ ++ Q+P+LF +L N+ D + + +E +F+ +LP +
Sbjct: 1368 FKITIIPQDPVLFSGSLRMNL---DPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECA 1424
Query: 1043 XXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITI 1102
+Q VC+ARAL+R ++L+LDEAT+A+D ++ + + + T +TI
Sbjct: 1425 EGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTI 1484
Query: 1103 AHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSK 1144
AHRL TI D + VLDKG+I E G ++L+ +G ++ ++K
Sbjct: 1485 AHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAK 1526
Score = 112 bits (270), Expect = 6e-24
Identities = 116/476 (24%), Positives = 205/476 (43%), Gaps = 31/476 (6%)
Query: 75 NLMKLKEGMGEKLAVVSNLVGTSIICLCTAFPLGW----KLALACITVMPFSIMASVALT 130
NLM + LA N++ ++ + + A L W LA + VM + + +
Sbjct: 425 NLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMA 484
Query: 131 NYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAFGGENIEVQRYKSLLEPAEISGSRRGL 190
+ M+S K E+L +K + + E + ++ + E+ ++
Sbjct: 485 MKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQE-ELKVLKKSA 543
Query: 191 FTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDANKPDDERTYIIGIVLSITFSVYMATQSI 250
+ F WV T L + + + I D N D +T + + L F++ +I
Sbjct: 544 YLSAVGTFTWVCTPFLVAL-CTFAVYVTI-DENNILDAQTAFVSLAL---FNILRFPLNI 598
Query: 251 TLCVPHMEVFATARGAAASIFSLLDKHPKIDCLSEAGSSPRRVIGEISLEDVHFSYPSRS 310
V V A+ IF L + + D + I++ + F++ +RS
Sbjct: 599 LPMVISSIVQASVSLKRLRIF-LSHEELEPDSIERRPVKDGGGTNSITVRNATFTW-ARS 656
Query: 311 DIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGW 370
D L G + I G VA+VG GCGKS++L L D +G V + G
Sbjct: 657 DPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG---------- 706
Query: 371 LRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAH-EFIKNLPNGYETVI 429
S+ V Q+ + ++ +NI G E YR A A ++ LP+G T I
Sbjct: 707 ---SVAYVPQQAWIQNDSLRENILFGCQ--LEEPYYRSVIQACALLPDLEILPSGDRTEI 761
Query: 430 GERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-QAALDRASV--GRT 486
GE+G +LSGGQKQR+++AR++ + L D+ SA+D H K + + + + +T
Sbjct: 762 GEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKT 821
Query: 487 TLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSGKETKEPEE 542
+ V+H +S + II M G I E G++ EL+ G + + + + T++ ++
Sbjct: 822 RILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQD 877
Score = 80.2 bits (189), Expect = 4e-14
Identities = 61/245 (24%), Positives = 107/245 (43%), Gaps = 21/245 (8%)
Query: 898 QDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRF 957
+D + + ++ + F++ R+ L GI + G VA+VG GCGKS++L +
Sbjct: 636 KDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAE 694
Query: 958 YDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEX 1017
D G++ + G + V Q+ + + +L ENI +G +P
Sbjct: 695 MDKVEGHVAIKG--------------SVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSV 740
Query: 1018 XXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSA 1077
+ LP G T KQRV +ARA+ + + L D+ SA
Sbjct: 741 IQACALLPD---LEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSA 797
Query: 1078 LDANSERAVTEAL---DHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIG 1134
+DA+ + + E + K +T I + H ++ + D+I V+ GKI E G++ EL+
Sbjct: 798 VDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLA 857
Query: 1135 LKGHY 1139
G +
Sbjct: 858 RDGAF 862
>EF419769-1|ABN79590.1| 1531|Homo sapiens ATP-binding cassette,
sub-family C (CFTR/MRP), member 1 protein.
Length = 1531
Score = 148 bits (359), Expect = 1e-34
Identities = 122/489 (24%), Positives = 234/489 (47%), Gaps = 24/489 (4%)
Query: 49 LTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAV----VSNLVGTSIICLCTA 104
L ++LR M++F+ NL ++ S+ L + + E + + + N++G I+ L A
Sbjct: 1053 LHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILL-A 1111
Query: 105 FPLGWKLALACITVMPFSIMASVALTNYQTKS-SIREMESYSQAGKQAE--EVLKSVKTV 161
P+ A I + P ++ Y S ++ +ES S++ + E L V +
Sbjct: 1112 TPI------AAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVI 1165
Query: 162 VAFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIED 221
AF E E ++S L+ E +++ + + W L L +G +
Sbjct: 1166 RAF--EEQERFIHQSDLKVDE---NQKAYYPSIVAN-RW-LAVRLECVGNCIVLFAALFA 1218
Query: 222 ANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKID 281
++G+ +S + V + ME A +S +K
Sbjct: 1219 VISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKE-YSETEKEAPWQ 1277
Query: 282 CLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
A S +G + + Y D +L+ ++ I GE V +VG +G GKS++
Sbjct: 1278 IQETAPPSSWPQVGRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSL 1336
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEAT 401
L R+ + +G + +DG N+ + + LR + ++ Q+PVLF G++ N+ + + +
Sbjct: 1337 TLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD-PFSQYS 1395
Query: 402 SEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 461
E+V+ E+A+ +F+ LP+ + E G +LS GQ+Q + +AR+LLR+ +L+LDE
Sbjct: 1396 DEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDE 1455
Query: 462 ATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELM 521
AT+A+D ++ +Q+ + T LT++HRL+TI++ R+I +D+G I E G +L+
Sbjct: 1456 ATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLL 1515
Query: 522 KAKGFYHKL 530
+ +G ++ +
Sbjct: 1516 QQRGLFYSM 1524
Score = 122 bits (295), Expect = 6e-27
Identities = 68/222 (30%), Positives = 124/222 (55%), Gaps = 4/222 (1%)
Query: 923 ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLR 982
+L+ I++ + G+ V +VG +G GKS++ + R + G I +DG++I K + L+ LR
Sbjct: 1309 VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAK-IGLHDLR 1367
Query: 983 KQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXX 1042
++ ++ Q+P+LF +L N+ D + + +E +F+ +LP +
Sbjct: 1368 FKITIIPQDPVLFSGSLRMNL---DPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECA 1424
Query: 1043 XXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITI 1102
+Q VC+ARAL+R ++L+LDEAT+A+D ++ + + + T +TI
Sbjct: 1425 EGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTI 1484
Query: 1103 AHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSK 1144
AHRL TI D + VLDKG+I E G ++L+ +G ++ ++K
Sbjct: 1485 AHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAK 1526
Score = 112 bits (270), Expect = 6e-24
Identities = 116/476 (24%), Positives = 205/476 (43%), Gaps = 31/476 (6%)
Query: 75 NLMKLKEGMGEKLAVVSNLVGTSIICLCTAFPLGW----KLALACITVMPFSIMASVALT 130
NLM + LA N++ ++ + + A L W LA + VM + + +
Sbjct: 425 NLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMA 484
Query: 131 NYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAFGGENIEVQRYKSLLEPAEISGSRRGL 190
+ M+S K E+L +K + + E + ++ + E+ ++
Sbjct: 485 MKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQE-ELKVLKKSA 543
Query: 191 FTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDANKPDDERTYIIGIVLSITFSVYMATQSI 250
+ F WV T L + + + I D N D +T + + L F++ +I
Sbjct: 544 YLSAVGTFTWVCTPFLVAL-CTFAVYVTI-DENNILDAQTAFVSLAL---FNILRFPLNI 598
Query: 251 TLCVPHMEVFATARGAAASIFSLLDKHPKIDCLSEAGSSPRRVIGEISLEDVHFSYPSRS 310
V V A+ IF L + + D + I++ + F++ +RS
Sbjct: 599 LPMVISSIVQASVSLKRLRIF-LSHEELEPDSIERRPVKDGGGTNSITVRNATFTW-ARS 656
Query: 311 DIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGW 370
D L G + I G VA+VG GCGKS++L L D +G V + G
Sbjct: 657 DPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG---------- 706
Query: 371 LRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAH-EFIKNLPNGYETVI 429
S+ V Q+ + ++ +NI G E YR A A ++ LP+G T I
Sbjct: 707 ---SVAYVPQQAWIQNDSLRENILFGCQ--LEEPYYRSVIQACALLPDLEILPSGDRTEI 761
Query: 430 GERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-QAALDRASV--GRT 486
GE+G +LSGGQKQR+++AR++ + L D+ SA+D H K + + + + +T
Sbjct: 762 GEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKT 821
Query: 487 TLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSGKETKEPEE 542
+ V+H +S + II M G I E G++ EL+ G + + + + T++ ++
Sbjct: 822 RILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQD 877
Score = 80.2 bits (189), Expect = 4e-14
Identities = 61/245 (24%), Positives = 107/245 (43%), Gaps = 21/245 (8%)
Query: 898 QDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRF 957
+D + + ++ + F++ R+ L GI + G VA+VG GCGKS++L +
Sbjct: 636 KDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAE 694
Query: 958 YDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEX 1017
D G++ + G + V Q+ + + +L ENI +G +P
Sbjct: 695 MDKVEGHVAIKG--------------SVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSV 740
Query: 1018 XXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSA 1077
+ LP G T KQRV +ARA+ + + L D+ SA
Sbjct: 741 IQACALLPD---LEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSA 797
Query: 1078 LDANSERAVTEAL---DHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIG 1134
+DA+ + + E + K +T I + H ++ + D+I V+ GKI E G++ EL+
Sbjct: 798 VDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLA 857
Query: 1135 LKGHY 1139
G +
Sbjct: 858 RDGAF 862
>AF022853-5|AAB83982.1| 1400|Homo sapiens multidrug resistance protein
protein.
Length = 1400
Score = 148 bits (359), Expect = 1e-34
Identities = 122/489 (24%), Positives = 234/489 (47%), Gaps = 24/489 (4%)
Query: 49 LTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAV----VSNLVGTSIICLCTA 104
L ++LR M++F+ NL ++ S+ L + + E + + + N++G I+ L A
Sbjct: 922 LHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILL-A 980
Query: 105 FPLGWKLALACITVMPFSIMASVALTNYQTKS-SIREMESYSQAGKQAE--EVLKSVKTV 161
P+ A I + P ++ Y S ++ +ES S++ + E L V +
Sbjct: 981 TPI------AAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVI 1034
Query: 162 VAFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIED 221
AF E E ++S L+ E +++ + + W L L +G +
Sbjct: 1035 RAF--EEQERFIHQSDLKVDE---NQKAYYPSIVAN-RW-LAVRLECVGNCIVLFAALFA 1087
Query: 222 ANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKID 281
++G+ +S + V + ME A +S +K
Sbjct: 1088 VISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKE-YSETEKEAPWQ 1146
Query: 282 CLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
A S +G + + Y D +L+ ++ I GE V +VG +G GKS++
Sbjct: 1147 IQETAPPSSWPQVGRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSL 1205
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEAT 401
L R+ + +G + +DG N+ + + LR + ++ Q+PVLF G++ N+ + + +
Sbjct: 1206 TLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD-PFSQYS 1264
Query: 402 SEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 461
E+V+ E+A+ +F+ LP+ + E G +LS GQ+Q + +AR+LLR+ +L+LDE
Sbjct: 1265 DEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDE 1324
Query: 462 ATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELM 521
AT+A+D ++ +Q+ + T LT++HRL+TI++ R+I +D+G I E G +L+
Sbjct: 1325 ATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLL 1384
Query: 522 KAKGFYHKL 530
+ +G ++ +
Sbjct: 1385 QQRGLFYSM 1393
Score = 122 bits (295), Expect = 6e-27
Identities = 68/222 (30%), Positives = 124/222 (55%), Gaps = 4/222 (1%)
Query: 923 ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLR 982
+L+ I++ + G+ V +VG +G GKS++ + R + G I +DG++I K + L+ LR
Sbjct: 1178 VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAK-IGLHDLR 1236
Query: 983 KQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXX 1042
++ ++ Q+P+LF +L N+ D + + +E +F+ +LP +
Sbjct: 1237 FKITIIPQDPVLFSGSLRMNL---DPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECA 1293
Query: 1043 XXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITI 1102
+Q VC+ARAL+R ++L+LDEAT+A+D ++ + + + T +TI
Sbjct: 1294 EGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTI 1353
Query: 1103 AHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSK 1144
AHRL TI D + VLDKG+I E G ++L+ +G ++ ++K
Sbjct: 1354 AHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAK 1395
Score = 56.0 bits (129), Expect = 7e-07
Identities = 68/301 (22%), Positives = 121/301 (40%), Gaps = 12/301 (3%)
Query: 75 NLMKLKEGMGEKLAVVSNLVGTSIICLCTAFPLGW----KLALACITVMPFSIMASVALT 130
NLM + LA N++ ++ + + A L W LA + VM + + +
Sbjct: 409 NLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMA 468
Query: 131 NYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAFGGENIEVQRYKSLLEPAEISGSRRGL 190
+ M+S K E+L +K + + E + ++ + E+ ++
Sbjct: 469 MKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQE-ELKVLKKSA 527
Query: 191 FTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDANKPDDERTYIIGIVLSITFSVYMATQSI 250
+ F WV T L + + + I D N D +T + + L F++ +I
Sbjct: 528 YLSAVGTFTWVCTPFLVAL-CTFAVYVTI-DENNILDAQTAFVSLAL---FNILRFPLNI 582
Query: 251 TLCVPHMEVFATARGAAASIFSLLDKHPKIDCLSEAGSSPRRVIGEISLEDVHFSYPSRS 310
V V A+ IF L + + D + I++ + F++ +RS
Sbjct: 583 LPMVISSIVQASVSLKRLRIF-LSHEELEPDSIERRPVKDGGGTNSITVRNATFTW-ARS 640
Query: 311 DIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGW 370
D L G + I G VA+VG GCGKS++L L D +G V + R L T ++ +
Sbjct: 641 DPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKTRILVTHSMSY 700
Query: 371 L 371
L
Sbjct: 701 L 701
Score = 39.9 bits (89), Expect = 0.051
Identities = 19/70 (27%), Positives = 36/70 (51%), Gaps = 1/70 (1%)
Query: 898 QDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRF 957
+D + + ++ + F++ R+ L GI + G VA+VG GCGKS++L +
Sbjct: 620 KDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAE 678
Query: 958 YDPTTGNIEL 967
D G++ +
Sbjct: 679 MDKVEGHVAI 688
Score = 34.3 bits (75), Expect = 2.6
Identities = 14/43 (32%), Positives = 25/43 (58%)
Query: 1097 RTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHY 1139
+T I + H ++ + D+I V+ GKI E G++ EL+ G +
Sbjct: 689 KTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAF 731
>AF022853-4|AAB83981.1| 1456|Homo sapiens multidrug resistance protein
protein.
Length = 1456
Score = 148 bits (359), Expect = 1e-34
Identities = 122/489 (24%), Positives = 234/489 (47%), Gaps = 24/489 (4%)
Query: 49 LTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAV----VSNLVGTSIICLCTA 104
L ++LR M++F+ NL ++ S+ L + + E + + + N++G I+ L A
Sbjct: 978 LHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILL-A 1036
Query: 105 FPLGWKLALACITVMPFSIMASVALTNYQTKS-SIREMESYSQAGKQAE--EVLKSVKTV 161
P+ A I + P ++ Y S ++ +ES S++ + E L V +
Sbjct: 1037 TPI------AAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVI 1090
Query: 162 VAFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIED 221
AF E E ++S L+ E +++ + + W L L +G +
Sbjct: 1091 RAF--EEQERFIHQSDLKVDE---NQKAYYPSIVAN-RW-LAVRLECVGNCIVLFAALFA 1143
Query: 222 ANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKID 281
++G+ +S + V + ME A +S +K
Sbjct: 1144 VISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKE-YSETEKEAPWQ 1202
Query: 282 CLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
A S +G + + Y D +L+ ++ I GE V +VG +G GKS++
Sbjct: 1203 IQETAPPSSWPQVGRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSL 1261
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEAT 401
L R+ + +G + +DG N+ + + LR + ++ Q+PVLF G++ N+ + + +
Sbjct: 1262 TLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD-PFSQYS 1320
Query: 402 SEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 461
E+V+ E+A+ +F+ LP+ + E G +LS GQ+Q + +AR+LLR+ +L+LDE
Sbjct: 1321 DEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDE 1380
Query: 462 ATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELM 521
AT+A+D ++ +Q+ + T LT++HRL+TI++ R+I +D+G I E G +L+
Sbjct: 1381 ATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLL 1440
Query: 522 KAKGFYHKL 530
+ +G ++ +
Sbjct: 1441 QQRGLFYSM 1449
Score = 122 bits (295), Expect = 6e-27
Identities = 68/222 (30%), Positives = 124/222 (55%), Gaps = 4/222 (1%)
Query: 923 ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLR 982
+L+ I++ + G+ V +VG +G GKS++ + R + G I +DG++I K + L+ LR
Sbjct: 1234 VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAK-IGLHDLR 1292
Query: 983 KQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXX 1042
++ ++ Q+P+LF +L N+ D + + +E +F+ +LP +
Sbjct: 1293 FKITIIPQDPVLFSGSLRMNL---DPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECA 1349
Query: 1043 XXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITI 1102
+Q VC+ARAL+R ++L+LDEAT+A+D ++ + + + T +TI
Sbjct: 1350 EGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTI 1409
Query: 1103 AHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSK 1144
AHRL TI D + VLDKG+I E G ++L+ +G ++ ++K
Sbjct: 1410 AHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAK 1451
Score = 61.7 bits (143), Expect = 1e-08
Identities = 33/114 (28%), Positives = 63/114 (55%), Gaps = 3/114 (2%)
Query: 432 RGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-QAALDRASV--GRTTL 488
+G +LSGGQKQR+++AR++ + L D+ SA+D H K + + + + +T +
Sbjct: 689 KGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRI 748
Query: 489 TVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSGKETKEPEE 542
V+H +S + II M G I E G++ EL+ G + + + + T++ ++
Sbjct: 749 LVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQD 802
Score = 56.4 bits (130), Expect = 6e-07
Identities = 67/293 (22%), Positives = 117/293 (39%), Gaps = 12/293 (4%)
Query: 75 NLMKLKEGMGEKLAVVSNLVGTSIICLCTAFPLGW----KLALACITVMPFSIMASVALT 130
NLM + LA N++ ++ + + A L W LA + VM + + +
Sbjct: 409 NLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMA 468
Query: 131 NYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAFGGENIEVQRYKSLLEPAEISGSRRGL 190
+ M+S K E+L +K + + E + ++ + E+ ++
Sbjct: 469 MKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQE-ELKVLKKSA 527
Query: 191 FTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDANKPDDERTYIIGIVLSITFSVYMATQSI 250
+ F WV T L + + + I D N D +T + + L F++ +I
Sbjct: 528 YLSAVGTFTWVCTPFLVAL-CTFAVYVTI-DENNILDAQTAFVSLAL---FNILRFPLNI 582
Query: 251 TLCVPHMEVFATARGAAASIFSLLDKHPKIDCLSEAGSSPRRVIGEISLEDVHFSYPSRS 310
V V A+ IF L + + D + I++ + F++ +RS
Sbjct: 583 LPMVISSIVQASVSLKRLRIF-LSHEELEPDSIERRPVKDGGGTNSITVRNATFTW-ARS 640
Query: 311 DIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNL 363
D L G + I G VA+VG GCGKS++L L D +G V + G NL
Sbjct: 641 DPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGVNL 693
Score = 53.2 bits (122), Expect = 5e-06
Identities = 29/90 (32%), Positives = 50/90 (55%), Gaps = 3/90 (3%)
Query: 1053 KQRVCIARALIRSPRLLLLDEATSALDANSERAVTEAL---DHAAKGRTCITIAHRLTTI 1109
KQRV +ARA+ + + L D+ SA+DA+ + + E + K +T I + H ++ +
Sbjct: 698 KQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYL 757
Query: 1110 KDADIICVLDKGKIVEKGNHAELIGLKGHY 1139
D+I V+ GKI E G++ EL+ G +
Sbjct: 758 PQVDVIIVMSGGKISEMGSYQELLARDGAF 787
Score = 45.2 bits (102), Expect = 0.001
Identities = 21/76 (27%), Positives = 41/76 (53%), Gaps = 1/76 (1%)
Query: 898 QDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRF 957
+D + + ++ + F++ R+ L GI + G VA+VG GCGKS++L +
Sbjct: 620 KDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAE 678
Query: 958 YDPTTGNIELDGVDIT 973
D G++ + GV+++
Sbjct: 679 MDKVEGHVAIKGVNLS 694
>AF022853-3|AAB83980.1| 1459|Homo sapiens multidrug resistance protein
protein.
Length = 1459
Score = 148 bits (359), Expect = 1e-34
Identities = 122/489 (24%), Positives = 234/489 (47%), Gaps = 24/489 (4%)
Query: 49 LTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAV----VSNLVGTSIICLCTA 104
L ++LR M++F+ NL ++ S+ L + + E + + + N++G I+ L A
Sbjct: 981 LHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILL-A 1039
Query: 105 FPLGWKLALACITVMPFSIMASVALTNYQTKS-SIREMESYSQAGKQAE--EVLKSVKTV 161
P+ A I + P ++ Y S ++ +ES S++ + E L V +
Sbjct: 1040 TPI------AAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVI 1093
Query: 162 VAFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIED 221
AF E E ++S L+ E +++ + + W L L +G +
Sbjct: 1094 RAF--EEQERFIHQSDLKVDE---NQKAYYPSIVAN-RW-LAVRLECVGNCIVLFAALFA 1146
Query: 222 ANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKID 281
++G+ +S + V + ME A +S +K
Sbjct: 1147 VISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKE-YSETEKEAPWQ 1205
Query: 282 CLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
A S +G + + Y D +L+ ++ I GE V +VG +G GKS++
Sbjct: 1206 IQETAPPSSWPQVGRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSL 1264
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEAT 401
L R+ + +G + +DG N+ + + LR + ++ Q+PVLF G++ N+ + + +
Sbjct: 1265 TLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD-PFSQYS 1323
Query: 402 SEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 461
E+V+ E+A+ +F+ LP+ + E G +LS GQ+Q + +AR+LLR+ +L+LDE
Sbjct: 1324 DEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDE 1383
Query: 462 ATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELM 521
AT+A+D ++ +Q+ + T LT++HRL+TI++ R+I +D+G I E G +L+
Sbjct: 1384 ATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLL 1443
Query: 522 KAKGFYHKL 530
+ +G ++ +
Sbjct: 1444 QQRGLFYSM 1452
Score = 122 bits (295), Expect = 6e-27
Identities = 68/222 (30%), Positives = 124/222 (55%), Gaps = 4/222 (1%)
Query: 923 ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLR 982
+L+ I++ + G+ V +VG +G GKS++ + R + G I +DG++I K + L+ LR
Sbjct: 1237 VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAK-IGLHDLR 1295
Query: 983 KQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXX 1042
++ ++ Q+P+LF +L N+ D + + +E +F+ +LP +
Sbjct: 1296 FKITIIPQDPVLFSGSLRMNL---DPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECA 1352
Query: 1043 XXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITI 1102
+Q VC+ARAL+R ++L+LDEAT+A+D ++ + + + T +TI
Sbjct: 1353 EGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTI 1412
Query: 1103 AHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSK 1144
AHRL TI D + VLDKG+I E G ++L+ +G ++ ++K
Sbjct: 1413 AHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAK 1454
Score = 56.0 bits (129), Expect = 7e-07
Identities = 82/363 (22%), Positives = 143/363 (39%), Gaps = 28/363 (7%)
Query: 75 NLMKLKEGMGEKLAVVSNLVGTSIICLCTAFPLGW----KLALACITVMPFSIMASVALT 130
NLM + LA N++ ++ + + A L W LA + VM + + +
Sbjct: 409 NLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMA 468
Query: 131 NYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAFGGENIEVQRYKSLLEPAEISGSRRGL 190
+ M+S K E+L +K + + E + ++ + E+ ++
Sbjct: 469 MKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQE-ELKVLKKSA 527
Query: 191 FTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDANKPDDERTYIIGIVLSITFSVYMATQSI 250
+ F WV T L + + + I D N D +T + + L F++ +I
Sbjct: 528 YLSAVGTFTWVCTPFLVAL-CTFAVYVTI-DENNILDAQTAFVSLAL---FNILRFPLNI 582
Query: 251 TLCVPHMEVFATARGAAASIFSLLDKHPKIDCLSEAGSSPRRVIGEISLEDVHFSYPSRS 310
V V A+ IF L + + D + I++ + F++ +RS
Sbjct: 583 LPMVISSIVQASVSLKRLRIF-LSHEELEPDSIERRPVKDGGGTNSITVRNATFTW-ARS 640
Query: 311 DIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGW 370
D L G + I G VA+VG GCGKS++L L D +G V + G
Sbjct: 641 DPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG---------- 690
Query: 371 LRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYR-VAEMAYAHEFIKNLPNGYETVI 429
S+ V Q+ + ++ +NI G E YR V + ++ LP+G T I
Sbjct: 691 ---SVAYVPQQAWIQNDSLRENILFGC--QLEEPYYRSVIQACALLPDLEILPSGDRTEI 745
Query: 430 GER 432
GE+
Sbjct: 746 GEK 748
Score = 41.9 bits (94), Expect = 0.013
Identities = 20/72 (27%), Positives = 37/72 (51%), Gaps = 1/72 (1%)
Query: 898 QDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRF 957
+D + + ++ + F++ R+ L GI + G VA+VG GCGKS++L +
Sbjct: 620 KDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAE 678
Query: 958 YDPTTGNIELDG 969
D G++ + G
Sbjct: 679 MDKVEGHVAIKG 690
Score = 35.5 bits (78), Expect = 1.1
Identities = 18/65 (27%), Positives = 35/65 (53%), Gaps = 1/65 (1%)
Query: 479 DRASVG-RTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSGKET 537
DR +G +T + V+H +S + II M G I E G++ EL+ G + + + + T
Sbjct: 741 DRTEIGEKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYAST 800
Query: 538 KEPEE 542
++ ++
Sbjct: 801 EQEQD 805
Score = 34.3 bits (75), Expect = 2.6
Identities = 14/43 (32%), Positives = 25/43 (58%)
Query: 1097 RTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHY 1139
+T I + H ++ + D+I V+ GKI E G++ EL+ G +
Sbjct: 748 KTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAF 790
>AF022853-1|AAB83979.1| 1515|Homo sapiens multidrug resistance protein
protein.
Length = 1515
Score = 148 bits (359), Expect = 1e-34
Identities = 122/489 (24%), Positives = 234/489 (47%), Gaps = 24/489 (4%)
Query: 49 LTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAV----VSNLVGTSIICLCTA 104
L ++LR M++F+ NL ++ S+ L + + E + + + N++G I+ L A
Sbjct: 1037 LHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILL-A 1095
Query: 105 FPLGWKLALACITVMPFSIMASVALTNYQTKS-SIREMESYSQAGKQAE--EVLKSVKTV 161
P+ A I + P ++ Y S ++ +ES S++ + E L V +
Sbjct: 1096 TPI------AAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVI 1149
Query: 162 VAFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIED 221
AF E E ++S L+ E +++ + + W L L +G +
Sbjct: 1150 RAF--EEQERFIHQSDLKVDE---NQKAYYPSIVAN-RW-LAVRLECVGNCIVLFAALFA 1202
Query: 222 ANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKID 281
++G+ +S + V + ME A +S +K
Sbjct: 1203 VISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKE-YSETEKEAPWQ 1261
Query: 282 CLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
A S +G + + Y D +L+ ++ I GE V +VG +G GKS++
Sbjct: 1262 IQETAPPSSWPQVGRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSL 1320
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEAT 401
L R+ + +G + +DG N+ + + LR + ++ Q+PVLF G++ N+ + + +
Sbjct: 1321 TLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD-PFSQYS 1379
Query: 402 SEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 461
E+V+ E+A+ +F+ LP+ + E G +LS GQ+Q + +AR+LLR+ +L+LDE
Sbjct: 1380 DEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDE 1439
Query: 462 ATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELM 521
AT+A+D ++ +Q+ + T LT++HRL+TI++ R+I +D+G I E G +L+
Sbjct: 1440 ATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLL 1499
Query: 522 KAKGFYHKL 530
+ +G ++ +
Sbjct: 1500 QQRGLFYSM 1508
Score = 122 bits (295), Expect = 6e-27
Identities = 68/222 (30%), Positives = 124/222 (55%), Gaps = 4/222 (1%)
Query: 923 ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLR 982
+L+ I++ + G+ V +VG +G GKS++ + R + G I +DG++I K + L+ LR
Sbjct: 1293 VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAK-IGLHDLR 1351
Query: 983 KQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXX 1042
++ ++ Q+P+LF +L N+ D + + +E +F+ +LP +
Sbjct: 1352 FKITIIPQDPVLFSGSLRMNL---DPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECA 1408
Query: 1043 XXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITI 1102
+Q VC+ARAL+R ++L+LDEAT+A+D ++ + + + T +TI
Sbjct: 1409 EGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTI 1468
Query: 1103 AHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSK 1144
AHRL TI D + VLDKG+I E G ++L+ +G ++ ++K
Sbjct: 1469 AHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAK 1510
Score = 112 bits (270), Expect = 6e-24
Identities = 116/476 (24%), Positives = 205/476 (43%), Gaps = 31/476 (6%)
Query: 75 NLMKLKEGMGEKLAVVSNLVGTSIICLCTAFPLGW----KLALACITVMPFSIMASVALT 130
NLM + LA N++ ++ + + A L W LA + VM + + +
Sbjct: 409 NLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMA 468
Query: 131 NYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAFGGENIEVQRYKSLLEPAEISGSRRGL 190
+ M+S K E+L +K + + E + ++ + E+ ++
Sbjct: 469 MKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQE-ELKVLKKSA 527
Query: 191 FTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDANKPDDERTYIIGIVLSITFSVYMATQSI 250
+ F WV T L + + + I D N D +T + + L F++ +I
Sbjct: 528 YLSAVGTFTWVCTPFLVAL-CTFAVYVTI-DENNILDAQTAFVSLAL---FNILRFPLNI 582
Query: 251 TLCVPHMEVFATARGAAASIFSLLDKHPKIDCLSEAGSSPRRVIGEISLEDVHFSYPSRS 310
V V A+ IF L + + D + I++ + F++ +RS
Sbjct: 583 LPMVISSIVQASVSLKRLRIF-LSHEELEPDSIERRPVKDGGGTNSITVRNATFTW-ARS 640
Query: 311 DIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGW 370
D L G + I G VA+VG GCGKS++L L D +G V + G
Sbjct: 641 DPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG---------- 690
Query: 371 LRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAH-EFIKNLPNGYETVI 429
S+ V Q+ + ++ +NI G E YR A A ++ LP+G T I
Sbjct: 691 ---SVAYVPQQAWIQNDSLRENILFGCQ--LEEPYYRSVIQACALLPDLEILPSGDRTEI 745
Query: 430 GERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-QAALDRASV--GRT 486
GE+G +LSGGQKQR+++AR++ + L D+ SA+D H K + + + + +T
Sbjct: 746 GEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKT 805
Query: 487 TLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSGKETKEPEE 542
+ V+H +S + II M G I E G++ EL+ G + + + + T++ ++
Sbjct: 806 RILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQD 861
Score = 80.2 bits (189), Expect = 4e-14
Identities = 61/245 (24%), Positives = 107/245 (43%), Gaps = 21/245 (8%)
Query: 898 QDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRF 957
+D + + ++ + F++ R+ L GI + G VA+VG GCGKS++L +
Sbjct: 620 KDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAE 678
Query: 958 YDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEX 1017
D G++ + G + V Q+ + + +L ENI +G +P
Sbjct: 679 MDKVEGHVAIKG--------------SVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSV 724
Query: 1018 XXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSA 1077
+ LP G T KQRV +ARA+ + + L D+ SA
Sbjct: 725 IQACALLPD---LEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSA 781
Query: 1078 LDANSERAVTEAL---DHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIG 1134
+DA+ + + E + K +T I + H ++ + D+I V+ GKI E G++ EL+
Sbjct: 782 VDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLA 841
Query: 1135 LKGHY 1139
G +
Sbjct: 842 RDGAF 846
>AB209120-1|BAD92357.1| 1439|Homo sapiens ATP-binding cassette,
sub-family C, member 1 isoform 1 variant protein.
Length = 1439
Score = 148 bits (359), Expect = 1e-34
Identities = 122/489 (24%), Positives = 234/489 (47%), Gaps = 24/489 (4%)
Query: 49 LTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAV----VSNLVGTSIICLCTA 104
L ++LR M++F+ NL ++ S+ L + + E + + + N++G I+ L A
Sbjct: 961 LHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILL-A 1019
Query: 105 FPLGWKLALACITVMPFSIMASVALTNYQTKS-SIREMESYSQAGKQAE--EVLKSVKTV 161
P+ A I + P ++ Y S ++ +ES S++ + E L V +
Sbjct: 1020 TPI------AAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVI 1073
Query: 162 VAFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIED 221
AF E E ++S L+ E +++ + + W L L +G +
Sbjct: 1074 RAF--EEQERFIHQSDLKVDE---NQKAYYPSIVAN-RW-LAVRLECVGNCIVLFAALFA 1126
Query: 222 ANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKID 281
++G+ +S + V + ME A +S +K
Sbjct: 1127 VISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKE-YSETEKEAPWQ 1185
Query: 282 CLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
A S +G + + Y D +L+ ++ I GE V +VG +G GKS++
Sbjct: 1186 IQETAPPSSWPQVGRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSL 1244
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEAT 401
L R+ + +G + +DG N+ + + LR + ++ Q+PVLF G++ N+ + + +
Sbjct: 1245 TLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD-PFSQYS 1303
Query: 402 SEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 461
E+V+ E+A+ +F+ LP+ + E G +LS GQ+Q + +AR+LLR+ +L+LDE
Sbjct: 1304 DEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDE 1363
Query: 462 ATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELM 521
AT+A+D ++ +Q+ + T LT++HRL+TI++ R+I +D+G I E G +L+
Sbjct: 1364 ATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLL 1423
Query: 522 KAKGFYHKL 530
+ +G ++ +
Sbjct: 1424 QQRGLFYSM 1432
Score = 122 bits (295), Expect = 6e-27
Identities = 68/222 (30%), Positives = 124/222 (55%), Gaps = 4/222 (1%)
Query: 923 ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLR 982
+L+ I++ + G+ V +VG +G GKS++ + R + G I +DG++I K + L+ LR
Sbjct: 1217 VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAK-IGLHDLR 1275
Query: 983 KQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXX 1042
++ ++ Q+P+LF +L N+ D + + +E +F+ +LP +
Sbjct: 1276 FKITIIPQDPVLFSGSLRMNL---DPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECA 1332
Query: 1043 XXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITI 1102
+Q VC+ARAL+R ++L+LDEAT+A+D ++ + + + T +TI
Sbjct: 1333 EGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTI 1392
Query: 1103 AHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSK 1144
AHRL TI D + VLDKG+I E G ++L+ +G ++ ++K
Sbjct: 1393 AHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAK 1434
Score = 118 bits (284), Expect = 1e-25
Identities = 125/498 (25%), Positives = 216/498 (43%), Gaps = 35/498 (7%)
Query: 75 NLMKLKEGMGEKLAVVSNLVGTSIICLCTAFPLGW----KLALACITVMPFSIMASVALT 130
NLM + LA N++ ++ + + A L W LA + VM + + +
Sbjct: 323 NLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMA 382
Query: 131 NYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAFGGENIEVQRYKSLLEPAEISGSRRGL 190
+ M+S K E+L +K + + E + ++ + E+ ++
Sbjct: 383 MKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQE-ELKVLKKSA 441
Query: 191 FTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDANKPDDERTYIIGIVLSITFSVYMATQSI 250
+ F WV T L + + + I D N D +T + + L F++ +I
Sbjct: 442 YLSAVGTFTWVCTPFLVAL-CTFAVYVTI-DENNILDAQTAFVSLAL---FNILRFPLNI 496
Query: 251 TLCVPHMEVFATARGAAASIFSLLDKHPKIDCLSEAGSSPRRVIGEISLEDVHFSYPSRS 310
V V A+ IF L + + D + I++ + F++ +RS
Sbjct: 497 LPMVISSIVQASVSLKRLRIF-LSHEELEPDSIERRPVKDGGGTNSITVRNATFTW-ARS 554
Query: 311 DIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGW 370
D L G + I G VA+VG GCGKS++L L D +G V + G
Sbjct: 555 DPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG---------- 604
Query: 371 LRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAH-EFIKNLPNGYETVI 429
S+ V Q+ + ++ +NI G E YR A A ++ LP+G T I
Sbjct: 605 ---SVAYVPQQAWIQNDSLRENILFGCQ--LEEPYYRSVIQACALLPDLEILPSGDRTEI 659
Query: 430 GERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-QAALDRASV--GRT 486
GE+G +LSGGQKQR+++AR++ + L D+ SA+D H K + + + + +T
Sbjct: 660 GEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKT 719
Query: 487 TLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLV---TSGKETKEPEEI 543
+ V+H +S + II M G I E G++ EL+ G + + + S ++ ++ EE
Sbjct: 720 RILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEEN 779
Query: 544 G-TVLEEQETKQNGELQP 560
G TV++E+E G P
Sbjct: 780 GSTVMDEEEAGVTGVSGP 797
Score = 80.2 bits (189), Expect = 4e-14
Identities = 61/245 (24%), Positives = 107/245 (43%), Gaps = 21/245 (8%)
Query: 898 QDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRF 957
+D + + ++ + F++ R+ L GI + G VA+VG GCGKS++L +
Sbjct: 534 KDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAE 592
Query: 958 YDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEX 1017
D G++ + G + V Q+ + + +L ENI +G +P
Sbjct: 593 MDKVEGHVAIKG--------------SVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSV 638
Query: 1018 XXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSA 1077
+ LP G T KQRV +ARA+ + + L D+ SA
Sbjct: 639 IQACALLPD---LEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSA 695
Query: 1078 LDANSERAVTEAL---DHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIG 1134
+DA+ + + E + K +T I + H ++ + D+I V+ GKI E G++ EL+
Sbjct: 696 VDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLA 755
Query: 1135 LKGHY 1139
G +
Sbjct: 756 RDGAF 760
>U63455-1|AAB36700.1| 1581|Homo sapiens sulfonylurea receptor protein.
Length = 1581
Score = 147 bits (357), Expect = 2e-34
Identities = 123/511 (24%), Positives = 244/511 (47%), Gaps = 26/511 (5%)
Query: 23 ILCNVLSVALVSWSALKQITTIRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEG 82
+LC V SV V W+ LK + + L ++ M +F+T ++ ++ S + + +
Sbjct: 1076 VLCLVTSVT-VEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQH 1134
Query: 83 MGEKLAVVSNLVGTSIICLCTAFPLGWKLALACITVMPFSIMASVALTNYQTKS-SIREM 141
+ L +S ++++C+ + + + + ++P +++ ++ S ++++
Sbjct: 1135 IPSTLECLSR---STLLCVSALAVISYVTPVFLVALLPLAVVCYFIQKYFRVASRDLQQL 1191
Query: 142 ESYSQAGKQAE--EVLKSVKTVVAFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFN 199
+ +Q + E ++ + T+ AF E + + LLE + S + LF N
Sbjct: 1192 DDTTQLPLLSHFAETVEGLTTIRAF---RYEARFQQKLLEYTD-SNNIASLFLTAAN--R 1245
Query: 200 WVLTYSLNTIGFMYGTRLIIEDANKPDDERTYIIGIV-LSITFSVYMATQSITLCVPHME 258
W L + IG + + R G+V L +T+++ M + + V ++
Sbjct: 1246 W-LEVRMEYIGACVVLIAAVTSISN-SLHRELSAGLVGLGLTYAL-MVSNYLNWMVRNLA 1302
Query: 259 VFATARGAAASIFSLLDKHPK-IDCLSEAGSSPRRVI--GEISLEDVHFSYPSRSDIKIL 315
GA I LL + + L P+ G+I ++++ Y S S +L
Sbjct: 1303 DMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDS-SLKPVL 1361
Query: 316 KGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSL 375
K + I PG+ + + G +G GKS+ R+ D +G + +DG +++ L + L S L
Sbjct: 1362 KHVNALISPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIRKLPLHTLPSRL 1421
Query: 376 GVVGQEPVLFRGTIYDNIAIGYPEATSED--VYRVAEMAYAHEFIKNLPNGYETVIGERG 433
++ Q+PVLF GTI N+ PE D ++ E+A +K LP G + +I E G
Sbjct: 1422 SIILQDPVLFSGTIRFNLD---PERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGG 1478
Query: 434 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVSHR 493
+ S GQ+Q +AR+ +R+ ++ ++DEAT+++D +E +Q + A RT +T++HR
Sbjct: 1479 ENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHR 1538
Query: 494 LSTIVNCHRIICMDQGTIIEQGTHVELMKAK 524
+ TI++ +I + +G I+E +L+ K
Sbjct: 1539 VHTILSADLVIVLKRGAILEFDKPEKLLSRK 1569
Score = 116 bits (279), Expect = 5e-25
Identities = 68/239 (28%), Positives = 119/239 (49%), Gaps = 5/239 (2%)
Query: 898 QDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRF 957
++W G I ++ Y + + +LK ++ + G+ + + G +G GKS+ R
Sbjct: 1336 KNWPDQGKIQIQNLSVRYDSSL-KPVLKHVNALISPGQKIGICGRTGSGKSSFSLAFFRM 1394
Query: 958 YDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEX 1017
D G+I +DG+DI K L L+ L +L ++ Q+P+LF T+ N+ D RK +
Sbjct: 1395 VDTFEGHIIIDGIDIRK-LPLHTLPSRLSIILQDPVLFSGTIRFNL---DPERKCSDSTL 1450
Query: 1018 XXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSA 1077
+ +LP G + +Q C+ARA +R + ++DEAT++
Sbjct: 1451 WEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATAS 1510
Query: 1078 LDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLK 1136
+D +E + + + A RT +TIAHR+ TI AD++ VL +G I+E +L+ K
Sbjct: 1511 IDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRK 1569
Score = 94.7 bits (225), Expect = 2e-18
Identities = 83/261 (31%), Positives = 126/261 (48%), Gaps = 22/261 (8%)
Query: 312 IKILKGFSLHIKPGESVALVGSSGCGKSTILQL----LQR---------LYDPNQGSVKL 358
I L ++ I G+ +VG GCGKS++L +Q+ L D G
Sbjct: 693 IPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPS 752
Query: 359 DGRNLKT-LNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEF 417
R T L+I R + Q+P L T+ +NI P + V E
Sbjct: 753 PERETATDLDIR-KRGPVAYASQKPWLLNATVEENIIFESP-FNKQRYKMVIEACSLQPD 810
Query: 418 IKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPH-SEKQVQA 476
I LP+G +T IGERG +LSGGQ+QRI++AR+L + V+ LD+ SALD H S+ +QA
Sbjct: 811 IDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLMQA 870
Query: 477 ALDR--ASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKG--FYHKLVT 532
+ RT + V+H+L + + II M GTI +GT + +++ F H
Sbjct: 871 GILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKTL 930
Query: 533 SGKETKEPEEIGTVLEEQETK 553
++ +E E+ TV E + T+
Sbjct: 931 MNRQDQELEK-ETVTERKATE 950
Score = 54.0 bits (124), Expect = 3e-06
Identities = 53/219 (24%), Positives = 90/219 (41%), Gaps = 18/219 (8%)
Query: 924 LKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNI---ELDGVDITKSLTLNR 980
L I + + G+ +VG GCGKS++L +G + L +I + + R
Sbjct: 696 LSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPSPER 755
Query: 981 -------LRKQ--LGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIV 1031
+RK+ + Q+P L + T+ ENI + K I
Sbjct: 756 ETATDLDIRKRGPVAYASQKPWLLNATVEENIIFESPFNK---QRYKMVIEACSLQPDID 812
Query: 1032 SLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDAN-SERAVTEAL 1090
LP G +T +QR+ +ARAL + ++ LD+ SALD + S+ + +
Sbjct: 813 ILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLMQAGI 872
Query: 1091 DHAAKG--RTCITIAHRLTTIKDADIICVLDKGKIVEKG 1127
+ RT + + H+L + AD I + G I +G
Sbjct: 873 LELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREG 911
>U63421-1|AAB36699.1| 1581|Homo sapiens sulfonylurea receptor protein.
Length = 1581
Score = 147 bits (357), Expect = 2e-34
Identities = 123/511 (24%), Positives = 244/511 (47%), Gaps = 26/511 (5%)
Query: 23 ILCNVLSVALVSWSALKQITTIRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEG 82
+LC V SV V W+ LK + + L ++ M +F+T ++ ++ S + + +
Sbjct: 1076 VLCLVTSVT-VEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQH 1134
Query: 83 MGEKLAVVSNLVGTSIICLCTAFPLGWKLALACITVMPFSIMASVALTNYQTKS-SIREM 141
+ L +S ++++C+ + + + + ++P +++ ++ S ++++
Sbjct: 1135 IPSTLECLSR---STLLCVSALAVISYVTPVFLVALLPLAVVCYFIQKYFRVASRDLQQL 1191
Query: 142 ESYSQAGKQAE--EVLKSVKTVVAFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFN 199
+ +Q + E ++ + T+ AF E + + LLE + S + LF N
Sbjct: 1192 DDTTQLPLLSHFAETVEGLTTIRAF---RYEARFQQKLLEYTD-SNNIASLFLTAAN--R 1245
Query: 200 WVLTYSLNTIGFMYGTRLIIEDANKPDDERTYIIGIV-LSITFSVYMATQSITLCVPHME 258
W L + IG + + R G+V L +T+++ M + + V ++
Sbjct: 1246 W-LEVRMEYIGACVVLIAAVTSISN-SLHRELSAGLVGLGLTYAL-MVSNYLNWMVRNLA 1302
Query: 259 VFATARGAAASIFSLLDKHPK-IDCLSEAGSSPRRVI--GEISLEDVHFSYPSRSDIKIL 315
GA I LL + + L P+ G+I ++++ Y S S +L
Sbjct: 1303 DMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDS-SLKPVL 1361
Query: 316 KGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSL 375
K + I PG+ + + G +G GKS+ R+ D +G + +DG +++ L + L S L
Sbjct: 1362 KHVNALISPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIRKLPLHTLPSRL 1421
Query: 376 GVVGQEPVLFRGTIYDNIAIGYPEATSED--VYRVAEMAYAHEFIKNLPNGYETVIGERG 433
++ Q+PVLF GTI N+ PE D ++ E+A +K LP G + +I E G
Sbjct: 1422 SIILQDPVLFSGTIRFNLD---PERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGG 1478
Query: 434 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVSHR 493
+ S GQ+Q +AR+ +R+ ++ ++DEAT+++D +E +Q + A RT +T++HR
Sbjct: 1479 ENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHR 1538
Query: 494 LSTIVNCHRIICMDQGTIIEQGTHVELMKAK 524
+ TI++ +I + +G I+E +L+ K
Sbjct: 1539 VHTILSADLVIVLKRGAILEFDKPEKLLSRK 1569
Score = 116 bits (279), Expect = 5e-25
Identities = 68/239 (28%), Positives = 119/239 (49%), Gaps = 5/239 (2%)
Query: 898 QDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRF 957
++W G I ++ Y + + +LK ++ + G+ + + G +G GKS+ R
Sbjct: 1336 KNWPDQGKIQIQNLSVRYDSSL-KPVLKHVNALISPGQKIGICGRTGSGKSSFSLAFFRM 1394
Query: 958 YDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEX 1017
D G+I +DG+DI K L L+ L +L ++ Q+P+LF T+ N+ D RK +
Sbjct: 1395 VDTFEGHIIIDGIDIRK-LPLHTLPSRLSIILQDPVLFSGTIRFNL---DPERKCSDSTL 1450
Query: 1018 XXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSA 1077
+ +LP G + +Q C+ARA +R + ++DEAT++
Sbjct: 1451 WEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATAS 1510
Query: 1078 LDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLK 1136
+D +E + + + A RT +TIAHR+ TI AD++ VL +G I+E +L+ K
Sbjct: 1511 IDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRK 1569
Score = 94.7 bits (225), Expect = 2e-18
Identities = 83/261 (31%), Positives = 126/261 (48%), Gaps = 22/261 (8%)
Query: 312 IKILKGFSLHIKPGESVALVGSSGCGKSTILQL----LQR---------LYDPNQGSVKL 358
I L ++ I G+ +VG GCGKS++L +Q+ L D G
Sbjct: 693 IPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPS 752
Query: 359 DGRNLKT-LNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEF 417
R T L+I R + Q+P L T+ +NI P + V E
Sbjct: 753 PERETATDLDIR-KRGPVAYASQKPWLLNATVEENIIFESP-FNKQRYKMVIEACSLQPD 810
Query: 418 IKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPH-SEKQVQA 476
I LP+G +T IGERG +LSGGQ+QRI++AR+L + V+ LD+ SALD H S+ +QA
Sbjct: 811 IDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLMQA 870
Query: 477 ALDR--ASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKG--FYHKLVT 532
+ RT + V+H+L + + II M GTI +GT + +++ F H
Sbjct: 871 GILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKTL 930
Query: 533 SGKETKEPEEIGTVLEEQETK 553
++ +E E+ TV E + T+
Sbjct: 931 MNRQDQELEK-ETVTERKATE 950
Score = 54.0 bits (124), Expect = 3e-06
Identities = 53/219 (24%), Positives = 90/219 (41%), Gaps = 18/219 (8%)
Query: 924 LKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNI---ELDGVDITKSLTLNR 980
L I + + G+ +VG GCGKS++L +G + L +I + + R
Sbjct: 696 LSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPSPER 755
Query: 981 -------LRKQ--LGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIV 1031
+RK+ + Q+P L + T+ ENI + K I
Sbjct: 756 ETATDLDIRKRGPVAYASQKPWLLNATVEENIIFESPFNK---QRYKMVIEACSLQPDID 812
Query: 1032 SLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDAN-SERAVTEAL 1090
LP G +T +QR+ +ARAL + ++ LD+ SALD + S+ + +
Sbjct: 813 ILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLMQAGI 872
Query: 1091 DHAAKG--RTCITIAHRLTTIKDADIICVLDKGKIVEKG 1127
+ RT + + H+L + AD I + G I +G
Sbjct: 873 LELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREG 911
>AB019002-1|BAA76608.1| 1437|Homo sapiens MRP5 protein.
Length = 1437
Score = 147 bits (357), Expect = 2e-34
Identities = 77/222 (34%), Positives = 127/222 (57%), Gaps = 2/222 (0%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
GE++ E+ Y + +LK S IKP E + +VG +G GKS++ L RL + + G
Sbjct: 1191 GEVTFENAEMRYRENLPL-VLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGG 1249
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+K+DG + + + LRS L ++ QEPVLF GT+ N+ + + T + ++ E +
Sbjct: 1250 CIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLD-PFNQYTEDQIWDALERTHM 1308
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
E I LP E+ + E G + S G++Q + IAR+LLR +L+LDEAT+A+D ++ +
Sbjct: 1309 KECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLI 1368
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGT 516
Q + A T L ++HRL T++ RI+ + QG ++E T
Sbjct: 1369 QETIREAFADCTMLNIAHRLHTVLGSDRIMVLAQGQVVEFDT 1410
Score = 121 bits (292), Expect = 1e-26
Identities = 109/457 (23%), Positives = 195/457 (42%), Gaps = 21/457 (4%)
Query: 677 ESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSV--TVGFIMAMSYNWKLTLVSTTF 734
++ G + R S D EV + + +Q V VG I + + W L V
Sbjct: 964 DTTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGV-FPWFLVAVGPLV 1022
Query: 735 LPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFITRFQDAL 794
+ V I ++ + + D + I T ++ + T+ + F+ R+Q+ L
Sbjct: 1023 ILFSVLHIVSRVLIRELKRLDNITQSPFLSHI-TSSIQGLATIHAYNKGQEFLHRYQELL 1081
Query: 795 IDACAAVVKKS---RWRGLVLGLCIYVPLLSYCSAVI---YGAVLVAHGXXXXXXXXXXX 848
D A + RW + L L I + L++ +I +G + A+
Sbjct: 1082 DDNQAPFFLFTCAMRWLAVRLDL-ISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLT 1140
Query: 849 XXXMYGAYMLGQSLVYAPSFNSAKTCGARILSIINREPRIRTVDGLNDKQDWSASGNFSI 908
+ + ++ F S + I ++ P + DW G +
Sbjct: 1141 GLFQFTVRLASET---EARFTSVERINHYIKTLSLEAPA--RIKNKAPSPDWPQEGEVTF 1195
Query: 909 NDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELD 968
+ E Y ++LK + ++ + + +VG +G GKS++ + R + + G I++D
Sbjct: 1196 ENAEMRYRENL-PLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKID 1254
Query: 969 GVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHN 1028
GV I+ + L LR +L ++ QEP+LF T+ N+ D + T D+
Sbjct: 1255 GVRIS-DIGLADLRSKLSIIPQEPVLFSGTVRSNL---DPFNQYTEDQIWDALERTHMKE 1310
Query: 1029 FIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTE 1088
I LP E+ +Q +CIARAL+R ++L+LDEAT+A+D ++ + E
Sbjct: 1311 CIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQE 1370
Query: 1089 ALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVE 1125
+ A T + IAHRL T+ +D I VL +G++VE
Sbjct: 1371 TIREAFADCTMLNIAHRLHTVLGSDRIMVLAQGQVVE 1407
Score = 118 bits (283), Expect = 2e-25
Identities = 84/283 (29%), Positives = 139/283 (49%), Gaps = 22/283 (7%)
Query: 313 KILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLR 372
+ L L I+ G+ V + GS G GK++++ + +GS+ + G
Sbjct: 576 RTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISG------------ 623
Query: 373 SSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGER 432
+ V Q+ + T+ DNI G E E V + LP+ T IGER
Sbjct: 624 -TFAYVAQQAWILNATLRDNILFG-KEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGER 681
Query: 433 GASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-QAALDRASVGRTTLTVS 491
GA+LSGGQ+QRI++AR+L + ++ +LD+ SALD H + +A+ + +T L V+
Sbjct: 682 GANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVT 741
Query: 492 HRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTS--GKETKEPEEIGTVLE- 548
H+L +V+C +I M +G I E+GTH ELM G Y + + ET P EI + E
Sbjct: 742 HQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLLGET-PPVEINSKKET 800
Query: 549 ---EQETKQNGELQPAVRPEPDVKRRSVRKLHRRQSAKGAHEW 588
+++++ G +V+ E VK + + + +G+ W
Sbjct: 801 SGSQKKSQDKGPKTGSVKKEKAVKPEEGQLVQLEEKGQGSVPW 843
Score = 77.4 bits (182), Expect = 3e-13
Identities = 57/220 (25%), Positives = 93/220 (42%), Gaps = 18/220 (8%)
Query: 921 QMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNR 980
Q L IDL ++ GK V + GS G GK++++ I G+I + G
Sbjct: 575 QRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGT---------- 624
Query: 981 LRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETN 1040
V Q+ + + TL +NI +G ++ + + LP T
Sbjct: 625 ----FAYVAQQAWILNATLRDNILFG---KEYDEERYNSVLNSCCLRPDLAILPSSDLTE 677
Query: 1041 XXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDAN-SERAVTEALDHAAKGRTC 1099
+QR+ +ARAL + +LD+ SALDA+ A+ K +T
Sbjct: 678 IGERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTV 737
Query: 1100 ITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHY 1139
+ + H+L + D D + + +G I E+G H EL+ L G Y
Sbjct: 738 LFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDY 777
>AB005659-1|BAA22887.1| 946|Homo sapiens SMRP protein.
Length = 946
Score = 147 bits (357), Expect = 2e-34
Identities = 77/222 (34%), Positives = 127/222 (57%), Gaps = 2/222 (0%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
GE++ E+ Y + +LK S IKP E + +VG +G GKS++ L RL + + G
Sbjct: 700 GEVTFENAEMRYRENLPL-VLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGG 758
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+K+DG + + + LRS L ++ QEPVLF GT+ N+ + + T + ++ E +
Sbjct: 759 CIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLD-PFNQYTEDQIWDALERTHM 817
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
E I LP E+ + E G + S G++Q + IAR+LLR +L+LDEAT+A+D ++ +
Sbjct: 818 KECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLI 877
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGT 516
Q + A T L ++HRL T++ RI+ + QG ++E T
Sbjct: 878 QETIREAFADCTMLNIAHRLHTVLGSDRIMVLAQGQVVEFDT 919
Score = 121 bits (292), Expect = 1e-26
Identities = 109/457 (23%), Positives = 195/457 (42%), Gaps = 21/457 (4%)
Query: 677 ESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSV--TVGFIMAMSYNWKLTLVSTTF 734
++ G + R S D EV + + +Q V VG I + + W L V
Sbjct: 473 DTTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGV-FPWFLVAVGPLV 531
Query: 735 LPLMVGSIWLEGIMSQKSQQDEREAMESATAIATEAVVSIKTVQSLGIESLFITRFQDAL 794
+ V I ++ + + D + I T ++ + T+ + F+ R+Q+ L
Sbjct: 532 ILFSVLHIVSRVLIRELKRLDNITQSPFLSHI-TSSIQGLATIHAYNKGQEFLHRYQELL 590
Query: 795 IDACAAVVKKS---RWRGLVLGLCIYVPLLSYCSAVI---YGAVLVAHGXXXXXXXXXXX 848
D A + RW + L L I + L++ +I +G + A+
Sbjct: 591 DDNQAPFFLFTCAMRWLAVRLDL-ISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLT 649
Query: 849 XXXMYGAYMLGQSLVYAPSFNSAKTCGARILSIINREPRIRTVDGLNDKQDWSASGNFSI 908
+ + ++ F S + I ++ P + DW G +
Sbjct: 650 GLFQFTVRLASET---EARFTSVERINHYIKTLSLEAPA--RIKNKAPSPDWPQEGEVTF 704
Query: 909 NDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELD 968
+ E Y ++LK + ++ + + +VG +G GKS++ + R + + G I++D
Sbjct: 705 ENAEMRYRENL-PLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKID 763
Query: 969 GVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHN 1028
GV I+ + L LR +L ++ QEP+LF T+ N+ D + T D+
Sbjct: 764 GVRIS-DIGLADLRSKLSIIPQEPVLFSGTVRSNL---DPFNQYTEDQIWDALERTHMKE 819
Query: 1029 FIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTE 1088
I LP E+ +Q +CIARAL+R ++L+LDEAT+A+D ++ + E
Sbjct: 820 CIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQE 879
Query: 1089 ALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVE 1125
+ A T + IAHRL T+ +D I VL +G++VE
Sbjct: 880 TIREAFADCTMLNIAHRLHTVLGSDRIMVLAQGQVVE 916
Score = 118 bits (283), Expect = 2e-25
Identities = 84/283 (29%), Positives = 139/283 (49%), Gaps = 22/283 (7%)
Query: 313 KILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLR 372
+ L L I+ G+ V + GS G GK++++ + +GS+ + G
Sbjct: 85 RTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISG------------ 132
Query: 373 SSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGER 432
+ V Q+ + T+ DNI G E E V + LP+ T IGER
Sbjct: 133 -TFAYVAQQAWILNATLRDNILFG-KEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGER 190
Query: 433 GASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-QAALDRASVGRTTLTVS 491
GA+LSGGQ+QRI++AR+L + ++ +LD+ SALD H + +A+ + +T L V+
Sbjct: 191 GANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVT 250
Query: 492 HRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTS--GKETKEPEEIGTVLE- 548
H+L +V+C +I M +G I E+GTH ELM G Y + + ET P EI + E
Sbjct: 251 HQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLLGET-PPVEINSKKET 309
Query: 549 ---EQETKQNGELQPAVRPEPDVKRRSVRKLHRRQSAKGAHEW 588
+++++ G +V+ E VK + + + +G+ W
Sbjct: 310 SGSQKKSQDKGPKTGSVKKEKAVKPEEGQLVQLEEKGQGSVPW 352
Score = 77.4 bits (182), Expect = 3e-13
Identities = 57/220 (25%), Positives = 93/220 (42%), Gaps = 18/220 (8%)
Query: 921 QMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNR 980
Q L IDL ++ GK V + GS G GK++++ I G+I + G
Sbjct: 84 QRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGT---------- 133
Query: 981 LRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETN 1040
V Q+ + + TL +NI +G ++ + + LP T
Sbjct: 134 ----FAYVAQQAWILNATLRDNILFG---KEYDEERYNSVLNSCCLRPDLAILPSSDLTE 186
Query: 1041 XXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDAN-SERAVTEALDHAAKGRTC 1099
+QR+ +ARAL + +LD+ SALDA+ A+ K +T
Sbjct: 187 IGERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTV 246
Query: 1100 ITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHY 1139
+ + H+L + D D + + +G I E+G H EL+ L G Y
Sbjct: 247 LFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDY 286
>AF352582-1|AAK19755.1| 1382|Homo sapiens ATP-binding cassette
transporter MRP8 protein.
Length = 1382
Score = 147 bits (355), Expect = 3e-34
Identities = 77/231 (33%), Positives = 129/231 (55%), Gaps = 2/231 (0%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
GEI +D H Y + +L G +L I+ E V +VG +G GKS++ L RL +P G
Sbjct: 1139 GEIIFQDYHMKYRDNTPT-VLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAG 1197
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+ +DG ++ ++ + LRS L V+ Q+PVL GTI N+ + T + ++ E +
Sbjct: 1198 RILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLD-PFDRHTDQQIWDALERTFL 1256
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
+ I P T + E G + S G++Q + IAR++LR ++L+DEAT+++D ++ +
Sbjct: 1257 TKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETDTLI 1316
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKG 525
Q + A G T L ++HR++T++NC RI+ M G ++E L K G
Sbjct: 1317 QRTIREAFQGCTVLVIAHRVTTVLNCDRILVMGNGKVVEFDRPEVLRKKPG 1367
Score = 127 bits (307), Expect = 2e-28
Identities = 72/235 (30%), Positives = 119/235 (50%), Gaps = 5/235 (2%)
Query: 891 VDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTV 950
++G + Q W G D Y +L GI+L + + V +VG +G GKS++
Sbjct: 1126 MEGTSCPQGWPQHGEIIFQDYHMKYRDNT-PTVLHGINLTIRGHEVVGIVGRTGSGKSSL 1184
Query: 951 LQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSR 1010
+ R +P G I +DGVDI S+ L LR +L V+ Q+P+L T+ N+ D
Sbjct: 1185 GMALFRLVEPMAGRILIDGVDIC-SIGLEDLRSKLSVIPQDPVLLSGTIRFNL---DPFD 1240
Query: 1011 KPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLL 1070
+ T + I PK T+ +Q +CIARA++R+ +++L
Sbjct: 1241 RHTDQQIWDALERTFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIIL 1300
Query: 1071 LDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVE 1125
+DEAT+++D ++ + + A +G T + IAHR+TT+ + D I V+ GK+VE
Sbjct: 1301 IDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDRILVMGNGKVVE 1355
Score = 111 bits (267), Expect = 1e-23
Identities = 73/220 (33%), Positives = 118/220 (53%), Gaps = 19/220 (8%)
Query: 315 LKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSS 374
L +L + G + + G++G GKS++L + +GSV + G S
Sbjct: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573
Query: 375 LGVVGQEPVLFRGTIYDNIAIG--YPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGER 432
L V Q+ + G I +NI +G Y +A V + + ++ LP G T IGER
Sbjct: 574 LAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSL---NRDLELLPFGDMTEIGER 630
Query: 433 GASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-QAALDRASVGRTTLTVS 491
G +LSGGQKQRI++AR++ + + LLD+ SA+D H K + + + + G+T + V+
Sbjct: 631 GPNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVQVT 690
Query: 492 HRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLV 531
H+L + C ++I ++ G I E GTH ELM+ KG Y +L+
Sbjct: 691 HQLQYLEFCGQVILLENGKICENGTHSELMQKKGKYAQLI 730
Score = 72.1 bits (169), Expect = 1e-11
Identities = 58/225 (25%), Positives = 99/225 (44%), Gaps = 18/225 (8%)
Query: 924 LKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRK 983
L I+L V G + + G++G GKS++L I G++ + G
Sbjct: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------- 572
Query: 984 QLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXX 1043
L V Q+ + + ENI G K + + LP G T
Sbjct: 573 SLAYVPQQAWIVSGNIRENILMGGAYDKA---RYLQVLHCCSLNRDLELLPFGDMTEIGE 629
Query: 1044 XXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAV-TEALDHAAKGRTCITI 1102
KQR+ +ARA+ ++ LLD+ SA+DA+ + + E + +G+T + +
Sbjct: 630 RGPNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVQV 689
Query: 1103 AHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSKQQN 1147
H+L ++ + +L+ GKI E G H+EL+ KG Y QL ++ +
Sbjct: 690 THQLQYLEFCGQVILLENGKICENGTHSELMQKKGKYAQLIQKMH 734
>AF061324-1|AAC16058.1| 1549|Homo sapiens sulfonylurea receptor 2B
protein.
Length = 1549
Score = 146 bits (354), Expect = 4e-34
Identities = 121/506 (23%), Positives = 230/506 (45%), Gaps = 28/506 (5%)
Query: 24 LCNVLSVALVSWSALKQITTIRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGM 83
LC V S+ V W L + L ++ + +FDT + ++ S + + + +
Sbjct: 1049 LCLVTSLT-VEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHI 1107
Query: 84 GEKLAVVSNLVGTSIICLCTAFPLGWKLALACITVMPFSIMASVALTNYQTKSS-IREME 142
L +L ++++CL + + + + ++P + ++ S ++E++
Sbjct: 1108 PPTL---ESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELD 1164
Query: 143 SYSQAGKQAE--EVLKSVKTVVAFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNW 200
+Q E + + T+ AF E QR L + I+ LF N W
Sbjct: 1165 DSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAY----LFLSAAN--RW 1218
Query: 201 VLTYSLNTIGFMYGTRLIIEDANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVF 260
L + +G I + + +G++ ++T + Y+ V ++
Sbjct: 1219 -LEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITNYL-----NWVVRNLADL 1272
Query: 261 ATARGAAASIFSLLDKHPK-IDCLSEAGSSPRR--VIGEISLEDVHFSYPSRSDIKILKG 317
GA + S L + + + P GEI + D+ Y + +LK
Sbjct: 1273 EVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLK-PVLKH 1331
Query: 318 FSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGV 377
+IKPG+ V + G +G GKS++ R+ D G + +DG ++ L + LRS L +
Sbjct: 1332 VKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSI 1391
Query: 378 VGQEPVLFRGTIYDNIAIGYPEA--TSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGAS 435
+ Q+P+LF G+I N+ PE T + ++ E+A +K+LP G + V+ E G +
Sbjct: 1392 ILQDPILFSGSIRFNLD---PECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGEN 1448
Query: 436 LSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLS 495
S GQ+Q +AR+ +R+ ++L++DEAT+++D +E +Q + A RT +T++HR+
Sbjct: 1449 FSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTMAHRVH 1508
Query: 496 TIVNCHRIICMDQGTIIEQGTHVELM 521
TI+ +I M +G I+E T L+
Sbjct: 1509 TILTADLVIVMKRGNILEYDTPESLL 1534
Score = 128 bits (308), Expect = 1e-28
Identities = 73/236 (30%), Positives = 122/236 (51%), Gaps = 5/236 (2%)
Query: 890 TVDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKST 949
T+D + W G I+D+ Y + +LK + +++ G+ V + G +G GKS+
Sbjct: 1296 TMDPSQVPEHWPQEGEIKIHDLCVRYENNL-KPVLKHVKAYIKPGQKVGICGRTGSGKSS 1354
Query: 950 VLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNS 1009
+ R D G I +DG+DI+K L L+ LR +L ++ Q+PILF ++ N+ D
Sbjct: 1355 LSLAFFRMVDIFDGKIVIDGIDISK-LPLHTLRSRLSIILQDPILFSGSIRFNL---DPE 1410
Query: 1010 RKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLL 1069
K T D N + SLP G + +Q C+ARA +R +L
Sbjct: 1411 CKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSIL 1470
Query: 1070 LLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVE 1125
++DEAT+++D +E + + + A RT +T+AHR+ TI AD++ V+ +G I+E
Sbjct: 1471 IMDEATASIDMATENILQKVVMTAFADRTVVTMAHRVHTILTADLVIVMKRGNILE 1526
Score = 102 bits (244), Expect = 8e-21
Identities = 71/227 (31%), Positives = 112/227 (49%), Gaps = 10/227 (4%)
Query: 297 ISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSV 356
I + + +FS+ S + L + I G+ +VG GCGKS++L + +G V
Sbjct: 672 IKVTNGYFSWGS--GLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKV 729
Query: 357 KLDGRNLKTLNIGWLRS----SLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMA 412
N + RS S+ Q+P L T+ +NI G P + V +
Sbjct: 730 HWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSP-FNKQRYKAVTDAC 788
Query: 413 YAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPH-SE 471
I LP G +T IGERG +LSGGQ+QRI +AR+L + ++ LD+ SALD H S+
Sbjct: 789 SLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSD 848
Query: 472 KQVQAALDR--ASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGT 516
+Q + + RT + V+H+L + + II M G+++ +GT
Sbjct: 849 HLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGT 895
Score = 81.0 bits (191), Expect = 2e-14
Identities = 56/210 (26%), Positives = 94/210 (44%), Gaps = 9/210 (4%)
Query: 924 LKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITK---SLTLNR 980
L ID+ + G+ +VG GCGKS++L I G + V+ ++ T +R
Sbjct: 688 LSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSR 747
Query: 981 LRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETN 1040
R + Q+P L + T+ ENI +G K I LP G +T
Sbjct: 748 NRYSVAYAAQKPWLLNATVEENITFGSPFNK---QRYKAVTDACSLQPDIDLLPFGDQTE 804
Query: 1041 XXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDAN-SERAVTEALDHAAKG--R 1097
+QR+C+ARAL ++ ++ LD+ SALD + S+ + E + + R
Sbjct: 805 IGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKR 864
Query: 1098 TCITIAHRLTTIKDADIICVLDKGKIVEKG 1127
T + + H+L + AD I + G ++ +G
Sbjct: 865 TLVLVTHKLQYLTHADWIIAMKDGSVLREG 894
>U91318-1|AAC15784.1| 401|Homo sapiens Multiple drug resistance
gene MRP1 (5' partial) protein.
Length = 401
Score = 146 bits (353), Expect = 5e-34
Identities = 74/237 (31%), Positives = 141/237 (59%), Gaps = 2/237 (0%)
Query: 294 IGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQ 353
+G + + Y D +L+ ++ I GE V +VG +G GKS++ L R+ + +
Sbjct: 160 VGRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAE 218
Query: 354 GSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAY 413
G + +DG N+ + + LR + ++ Q+PVLF G++ N+ + + + E+V+ E+A+
Sbjct: 219 GEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD-PFSQYSDEEVWTSLELAH 277
Query: 414 AHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQ 473
+F+ LP+ + E G +LS GQ+Q + +AR+LLR+ +L+LDEAT+A+D ++
Sbjct: 278 LKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDL 337
Query: 474 VQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKL 530
+Q+ + T LT++HRL+TI++ R+I +D+G I E G +L++ +G ++ +
Sbjct: 338 IQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSM 394
Score = 122 bits (295), Expect = 6e-27
Identities = 68/222 (30%), Positives = 124/222 (55%), Gaps = 4/222 (1%)
Query: 923 ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLR 982
+L+ I++ + G+ V +VG +G GKS++ + R + G I +DG++I K + L+ LR
Sbjct: 179 VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAK-IGLHDLR 237
Query: 983 KQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXX 1042
++ ++ Q+P+LF +L N+ D + + +E +F+ +LP +
Sbjct: 238 FKITIIPQDPVLFSGSLRMNL---DPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECA 294
Query: 1043 XXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITI 1102
+Q VC+ARAL+R ++L+LDEAT+A+D ++ + + + T +TI
Sbjct: 295 EGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTI 354
Query: 1103 AHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSK 1144
AHRL TI D + VLDKG+I E G ++L+ +G ++ ++K
Sbjct: 355 AHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAK 396
>BC001636-1|AAH01636.1| 316|Homo sapiens Unknown (protein for
IMAGE:3355848) protein.
Length = 316
Score = 146 bits (353), Expect = 5e-34
Identities = 74/237 (31%), Positives = 141/237 (59%), Gaps = 2/237 (0%)
Query: 294 IGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQ 353
+G + + Y D +L+ ++ I GE V +VG +G GKS++ L R+ + +
Sbjct: 75 VGRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAE 133
Query: 354 GSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAY 413
G + +DG N+ + + LR + ++ Q+PVLF G++ N+ + + + E+V+ E+A+
Sbjct: 134 GEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD-PFSQYSDEEVWTSLELAH 192
Query: 414 AHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQ 473
+F+ LP+ + E G +LS GQ+Q + +AR+LLR+ +L+LDEAT+A+D ++
Sbjct: 193 LKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDL 252
Query: 474 VQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKL 530
+Q+ + T LT++HRL+TI++ R+I +D+G I E G +L++ +G ++ +
Sbjct: 253 IQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSM 309
Score = 122 bits (295), Expect = 6e-27
Identities = 68/222 (30%), Positives = 124/222 (55%), Gaps = 4/222 (1%)
Query: 923 ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLR 982
+L+ I++ + G+ V +VG +G GKS++ + R + G I +DG++I K + L+ LR
Sbjct: 94 VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAK-IGLHDLR 152
Query: 983 KQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXX 1042
++ ++ Q+P+LF +L N+ D + + +E +F+ +LP +
Sbjct: 153 FKITIIPQDPVLFSGSLRMNL---DPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECA 209
Query: 1043 XXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITI 1102
+Q VC+ARAL+R ++L+LDEAT+A+D ++ + + + T +TI
Sbjct: 210 EGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTI 269
Query: 1103 AHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSK 1144
AHRL TI D + VLDKG+I E G ++L+ +G ++ ++K
Sbjct: 270 AHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAK 311
>AY490254-1|AAR99172.1| 164|Homo sapiens P-glycoprotein protein.
Length = 164
Score = 145 bits (352), Expect = 7e-34
Identities = 71/163 (43%), Positives = 105/163 (64%), Gaps = 17/163 (10%)
Query: 278 PKIDCLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCG 337
P ID S++G P + G + +VHFSYPSR ++KILKG +L ++ G++VALVG+SGCG
Sbjct: 2 PSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCG 61
Query: 338 KSTILQLLQRLYDPNQG-----------------SVKLDGRNLKTLNIGWLRSSLGVVGQ 380
KST +QL+QRLYDP +G V +DG++++T+N+ +LR +GVV Q
Sbjct: 62 KSTTVQLMQRLYDPTEGMLPFQLQMYESHTYFLFQVSVDGQDIRTINVRFLREIIGVVSQ 121
Query: 381 EPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPN 423
EPVLF TI +NI G T +++ + + A A++FI LP+
Sbjct: 122 EPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPH 164
Score = 119 bits (287), Expect = 5e-26
Identities = 70/167 (41%), Positives = 96/167 (57%), Gaps = 21/167 (12%)
Query: 885 EPRIRTVDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSG 944
+P I + K D + GN +V FSYP+R ILKG++L V++G+TVALVG+SG
Sbjct: 1 KPSIDSYSKSGHKPD-NIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSG 59
Query: 945 CGKSTVLQLIQRFYDPTTG-----------------NIELDGVDITKSLTLNRLRKQLGV 987
CGKST +QL+QR YDPT G + +DG DI +++ + LR+ +GV
Sbjct: 60 CGKSTTVQLMQRLYDPTEGMLPFQLQMYESHTYFLFQVSVDGQDI-RTINVRFLREIIGV 118
Query: 988 VQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLP 1034
V QEP+LF T+AENI YG TMDE ++FI+ LP
Sbjct: 119 VSQEPVLFATTIAENIRYG--RENVTMDEIEKAVKEANAYDFIMKLP 163
>BC024103-1|AAH24103.1| 282|Homo sapiens ABCC10 protein protein.
Length = 282
Score = 145 bits (351), Expect = 9e-34
Identities = 78/245 (31%), Positives = 143/245 (58%), Gaps = 8/245 (3%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G + +DV +Y L G + ++PGE + +VG +G GKS++L +L RL +P+ G
Sbjct: 34 GGVEFQDVVLAYRPGLP-NALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSG 92
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSED--VYRVAEMA 412
V LDG + L + LRS L ++ QEP LF GT+ +N+ P+ +D +++ +
Sbjct: 93 RVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLD---PQGLHKDRALWQALKQC 149
Query: 413 YAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEK 472
+ E I ++ G + +GE G SLS GQ+Q + +AR+LL + +L +DEAT+++D +++
Sbjct: 150 HLSEVITSM-GGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQ 208
Query: 473 QVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELM-KAKGFYHKLV 531
+Q + + +T LT++HRL+TI+N R++ + G ++E + L + + +L+
Sbjct: 209 LLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQLL 268
Query: 532 TSGKE 536
S ++
Sbjct: 269 QSSQQ 273
Score = 122 bits (294), Expect = 7e-27
Identities = 70/233 (30%), Positives = 121/233 (51%), Gaps = 6/233 (2%)
Query: 900 WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYD 959
W G DV +Y L G+ V+ G+ + +VG +G GKS++L ++ R +
Sbjct: 30 WLTQGGVEFQDVVLAYRPGLPNA-LDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLE 88
Query: 960 PTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXX 1019
P++G + LDGVD T L L +LR QL ++ QEP LF T+ EN+ + + D
Sbjct: 89 PSSGRVLLDGVD-TSQLELAQLRSQLAIIPQEPFLFSGTVRENL----DPQGLHKDRALW 143
Query: 1020 XXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALD 1079
+ +++ G + +Q +C+ARAL+ ++L +DEAT+++D
Sbjct: 144 QALKQCHLSEVITSMGGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVD 203
Query: 1080 ANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAEL 1132
+++ + + + +T +TIAHRL TI ++D + VL G++VE + A L
Sbjct: 204 QKTDQLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATL 256
>AL359813-2|CAI23217.1| 1492|Homo sapiens ATP-binding cassette,
sub-family C (CFTR/MRP), member 10 protein.
Length = 1492
Score = 145 bits (351), Expect = 9e-34
Identities = 78/245 (31%), Positives = 143/245 (58%), Gaps = 8/245 (3%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G + +DV +Y L G + ++PGE + +VG +G GKS++L +L RL +P+ G
Sbjct: 1244 GGVEFQDVVLAYRPGLP-NALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSG 1302
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSED--VYRVAEMA 412
V LDG + L + LRS L ++ QEP LF GT+ +N+ P+ +D +++ +
Sbjct: 1303 RVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLD---PQGLHKDRALWQALKQC 1359
Query: 413 YAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEK 472
+ E I ++ G + +GE G SLS GQ+Q + +AR+LL + +L +DEAT+++D +++
Sbjct: 1360 HLSEVITSM-GGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQ 1418
Query: 473 QVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELM-KAKGFYHKLV 531
+Q + + +T LT++HRL+TI+N R++ + G ++E + L + + +L+
Sbjct: 1419 LLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQLL 1478
Query: 532 TSGKE 536
S ++
Sbjct: 1479 QSSQQ 1483
Score = 122 bits (294), Expect = 7e-27
Identities = 70/233 (30%), Positives = 121/233 (51%), Gaps = 6/233 (2%)
Query: 900 WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYD 959
W G DV +Y L G+ V+ G+ + +VG +G GKS++L ++ R +
Sbjct: 1240 WLTQGGVEFQDVVLAYRPGLPNA-LDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLE 1298
Query: 960 PTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXX 1019
P++G + LDGVD T L L +LR QL ++ QEP LF T+ EN+ + + D
Sbjct: 1299 PSSGRVLLDGVD-TSQLELAQLRSQLAIIPQEPFLFSGTVRENL----DPQGLHKDRALW 1353
Query: 1020 XXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALD 1079
+ +++ G + +Q +C+ARAL+ ++L +DEAT+++D
Sbjct: 1354 QALKQCHLSEVITSMGGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVD 1413
Query: 1080 ANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAEL 1132
+++ + + + +T +TIAHRL TI ++D + VL G++VE + A L
Sbjct: 1414 QKTDQLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATL 1466
Score = 91.9 bits (218), Expect = 1e-17
Identities = 76/295 (25%), Positives = 131/295 (44%), Gaps = 24/295 (8%)
Query: 320 LHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVG 379
L +K G V +VG GCGKS++L + +G V + G L G+
Sbjct: 621 LEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRG----------LSKGFGLAT 670
Query: 380 QEPVLFRGTIYDNIAIGYPEATSEDVYR-VAEMAYAHEFIKNLPNGYETVIGERGASLSG 438
QEP + TI DNI G + +Y+ V E ++ + LP G +T +GE+G +LSG
Sbjct: 671 QEPWIQFATIRDNILFG--KTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSG 728
Query: 439 GQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTT-LTVSHRLSTI 497
GQ+ RIA+AR++ +E + LLD+ +A+D + + TT L +HR +
Sbjct: 729 GQRARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRLLCTHRTEYL 788
Query: 498 VNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSGKETKEPEEIGTVLEEQETKQNGE 557
++ M+ G +I G E++ K + + +V ++TK+
Sbjct: 789 ERADAVLLMEAGRLIRAGPPSEILPLVQAVPKAWAENGQESDSATAQSVQNPEKTKE--- 845
Query: 558 LQPAVRPEPDVKRRSVRKLHRRQSAKGAH----EWMATPRGSISSIMSTALQSHA 608
+ E R +++ +++ A H W A +G +I+ + L A
Sbjct: 846 ---GLEEEQSTSGRLLQEESKKEGAVALHVYQAYWKAVGQGLALAILFSLLLMQA 897
Score = 65.3 bits (152), Expect = 1e-09
Identities = 50/208 (24%), Positives = 91/208 (43%), Gaps = 15/208 (7%)
Query: 929 LHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVV 988
L V+ G V +VG GCGKS++L I G++ + G L K G+
Sbjct: 621 LEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRG-----------LSKGFGLA 669
Query: 989 QQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXX 1048
QEP + T+ +NI +G E ++ + LP G +T
Sbjct: 670 TQEPWIQFATIRDNILFGKTFDAQLYKEVLEACAL---NDDLSILPAGDQTEVGEKGVTL 726
Query: 1049 XXXXKQRVCIARALIRSPRLLLLDEATSALDAN-SERAVTEALDHAAKGRTCITIAHRLT 1107
+ R+ +ARA+ + L LLD+ +A+DA+ + + + T + HR
Sbjct: 727 SGGQRARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRLLCTHRTE 786
Query: 1108 TIKDADIICVLDKGKIVEKGNHAELIGL 1135
++ AD + +++ G+++ G +E++ L
Sbjct: 787 YLERADAVLLMEAGRLIRAGPPSEILPL 814
>AL133613-1|CAB63742.1| 700|Homo sapiens hypothetical protein
protein.
Length = 700
Score = 145 bits (351), Expect = 9e-34
Identities = 78/245 (31%), Positives = 143/245 (58%), Gaps = 8/245 (3%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G + +DV +Y L G + ++PGE + +VG +G GKS++L +L RL +P+ G
Sbjct: 452 GGVEFQDVVLAYRPGLP-NALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSG 510
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSED--VYRVAEMA 412
V LDG + L + LRS L ++ QEP LF GT+ +N+ P+ +D +++ +
Sbjct: 511 RVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLD---PQGLHKDRALWQALKQC 567
Query: 413 YAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEK 472
+ E I ++ G + +GE G SLS GQ+Q + +AR+LL + +L +DEAT+++D +++
Sbjct: 568 HLSEVITSM-GGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQ 626
Query: 473 QVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELM-KAKGFYHKLV 531
+Q + + +T LT++HRL+TI+N R++ + G ++E + L + + +L+
Sbjct: 627 LLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQLL 686
Query: 532 TSGKE 536
S ++
Sbjct: 687 QSSQQ 691
Score = 122 bits (294), Expect = 7e-27
Identities = 70/233 (30%), Positives = 121/233 (51%), Gaps = 6/233 (2%)
Query: 900 WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYD 959
W G DV +Y L G+ V+ G+ + +VG +G GKS++L ++ R +
Sbjct: 448 WLTQGGVEFQDVVLAYRPGLPNA-LDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLE 506
Query: 960 PTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXX 1019
P++G + LDGVD T L L +LR QL ++ QEP LF T+ EN+ + + D
Sbjct: 507 PSSGRVLLDGVD-TSQLELAQLRSQLAIIPQEPFLFSGTVRENL----DPQGLHKDRALW 561
Query: 1020 XXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALD 1079
+ +++ G + +Q +C+ARAL+ ++L +DEAT+++D
Sbjct: 562 QALKQCHLSEVITSMGGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVD 621
Query: 1080 ANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAEL 1132
+++ + + + +T +TIAHRL TI ++D + VL G++VE + A L
Sbjct: 622 QKTDQLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATL 674
>AK024446-1|BAB15736.1| 706|Homo sapiens FLJ00036 protein protein.
Length = 706
Score = 145 bits (351), Expect = 9e-34
Identities = 78/245 (31%), Positives = 143/245 (58%), Gaps = 8/245 (3%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G + +DV +Y L G + ++PGE + +VG +G GKS++L +L RL +P+ G
Sbjct: 458 GGVEFQDVVLAYRPGLP-NALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSG 516
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSED--VYRVAEMA 412
V LDG + L + LRS L ++ QEP LF GT+ +N+ P+ +D +++ +
Sbjct: 517 RVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLD---PQGLHKDRALWQALKQC 573
Query: 413 YAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEK 472
+ E I ++ G + +GE G SLS GQ+Q + +AR+LL + +L +DEAT+++D +++
Sbjct: 574 HLSEVITSM-GGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQ 632
Query: 473 QVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELM-KAKGFYHKLV 531
+Q + + +T LT++HRL+TI+N R++ + G ++E + L + + +L+
Sbjct: 633 LLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQLL 692
Query: 532 TSGKE 536
S ++
Sbjct: 693 QSSQQ 697
Score = 122 bits (294), Expect = 7e-27
Identities = 70/233 (30%), Positives = 121/233 (51%), Gaps = 6/233 (2%)
Query: 900 WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYD 959
W G DV +Y L G+ V+ G+ + +VG +G GKS++L ++ R +
Sbjct: 454 WLTQGGVEFQDVVLAYRPGLPNA-LDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLE 512
Query: 960 PTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXX 1019
P++G + LDGVD T L L +LR QL ++ QEP LF T+ EN+ + + D
Sbjct: 513 PSSGRVLLDGVD-TSQLELAQLRSQLAIIPQEPFLFSGTVRENL----DPQGLHKDRALW 567
Query: 1020 XXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALD 1079
+ +++ G + +Q +C+ARAL+ ++L +DEAT+++D
Sbjct: 568 QALKQCHLSEVITSMGGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVD 627
Query: 1080 ANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAEL 1132
+++ + + + +T +TIAHRL TI ++D + VL G++VE + A L
Sbjct: 628 QKTDQLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATL 680
>AK000002-1|BAA92227.1| 1513|Homo sapiens FLJ00002 protein protein.
Length = 1513
Score = 145 bits (351), Expect = 9e-34
Identities = 78/245 (31%), Positives = 143/245 (58%), Gaps = 8/245 (3%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G + +DV +Y L G + ++PGE + +VG +G GKS++L +L RL +P+ G
Sbjct: 1265 GGVEFQDVVLAYRPGLP-NALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSG 1323
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSED--VYRVAEMA 412
V LDG + L + LRS L ++ QEP LF GT+ +N+ P+ +D +++ +
Sbjct: 1324 RVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLD---PQGLHKDRALWQALKQC 1380
Query: 413 YAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEK 472
+ E I ++ G + +GE G SLS GQ+Q + +AR+LL + +L +DEAT+++D +++
Sbjct: 1381 HLSEVITSM-GGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQ 1439
Query: 473 QVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELM-KAKGFYHKLV 531
+Q + + +T LT++HRL+TI+N R++ + G ++E + L + + +L+
Sbjct: 1440 LLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQLL 1499
Query: 532 TSGKE 536
S ++
Sbjct: 1500 QSSQQ 1504
Score = 122 bits (294), Expect = 7e-27
Identities = 70/233 (30%), Positives = 121/233 (51%), Gaps = 6/233 (2%)
Query: 900 WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYD 959
W G DV +Y L G+ V+ G+ + +VG +G GKS++L ++ R +
Sbjct: 1261 WLTQGGVEFQDVVLAYRPGLPNA-LDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLE 1319
Query: 960 PTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXX 1019
P++G + LDGVD T L L +LR QL ++ QEP LF T+ EN+ + + D
Sbjct: 1320 PSSGRVLLDGVD-TSQLELAQLRSQLAIIPQEPFLFSGTVRENL----DPQGLHKDRALW 1374
Query: 1020 XXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALD 1079
+ +++ G + +Q +C+ARAL+ ++L +DEAT+++D
Sbjct: 1375 QALKQCHLSEVITSMGGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVD 1434
Query: 1080 ANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAEL 1132
+++ + + + +T +TIAHRL TI ++D + VL G++VE + A L
Sbjct: 1435 QKTDQLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATL 1487
Score = 91.9 bits (218), Expect = 1e-17
Identities = 76/295 (25%), Positives = 131/295 (44%), Gaps = 24/295 (8%)
Query: 320 LHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVG 379
L +K G V +VG GCGKS++L + +G V + G L G+
Sbjct: 642 LEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRG----------LSKGFGLAT 691
Query: 380 QEPVLFRGTIYDNIAIGYPEATSEDVYR-VAEMAYAHEFIKNLPNGYETVIGERGASLSG 438
QEP + TI DNI G + +Y+ V E ++ + LP G +T +GE+G +LSG
Sbjct: 692 QEPWIQFATIRDNILFG--KTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSG 749
Query: 439 GQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTT-LTVSHRLSTI 497
GQ+ RIA+AR++ +E + LLD+ +A+D + + TT L +HR +
Sbjct: 750 GQRARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRLLCTHRTEYL 809
Query: 498 VNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSGKETKEPEEIGTVLEEQETKQNGE 557
++ M+ G +I G E++ K + + +V ++TK+
Sbjct: 810 ERADAVLLMEAGRLIRAGPPSEILPLVQAVPKAWAENGQESDSATAQSVQNPEKTKE--- 866
Query: 558 LQPAVRPEPDVKRRSVRKLHRRQSAKGAH----EWMATPRGSISSIMSTALQSHA 608
+ E R +++ +++ A H W A +G +I+ + L A
Sbjct: 867 ---GLEEEQSTSGRLLQEESKKEGAVALHVYQAYWKAVGQGLALAILFSLLLMQA 918
Score = 65.3 bits (152), Expect = 1e-09
Identities = 50/208 (24%), Positives = 91/208 (43%), Gaps = 15/208 (7%)
Query: 929 LHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVV 988
L V+ G V +VG GCGKS++L I G++ + G L K G+
Sbjct: 642 LEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRG-----------LSKGFGLA 690
Query: 989 QQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXX 1048
QEP + T+ +NI +G E ++ + LP G +T
Sbjct: 691 TQEPWIQFATIRDNILFGKTFDAQLYKEVLEACAL---NDDLSILPAGDQTEVGEKGVTL 747
Query: 1049 XXXXKQRVCIARALIRSPRLLLLDEATSALDAN-SERAVTEALDHAAKGRTCITIAHRLT 1107
+ R+ +ARA+ + L LLD+ +A+DA+ + + + T + HR
Sbjct: 748 SGGQRARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRLLCTHRTE 807
Query: 1108 TIKDADIICVLDKGKIVEKGNHAELIGL 1135
++ AD + +++ G+++ G +E++ L
Sbjct: 808 YLERADAVLLMEAGRLIRAGPPSEILPL 835
>AY040219-1|AAK76739.1| 1382|Homo sapiens ATP-binding cassette
transporter sub-family C member 11 protein.
Length = 1382
Score = 144 bits (350), Expect = 1e-33
Identities = 76/231 (32%), Positives = 128/231 (55%), Gaps = 2/231 (0%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
GEI +D H Y + +L G +L I+ E V +VG +G GKS++ L RL +P G
Sbjct: 1139 GEIIFQDYHMKYRDNTPT-VLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAG 1197
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+ +DG ++ ++ + LRS L V+ Q+PVL GTI N+ + T + ++ E +
Sbjct: 1198 RILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLD-PFDRHTDQQIWDALERTFL 1256
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
+ I P T + E G + S G++Q + IAR++LR ++L+DEAT+++D ++ +
Sbjct: 1257 TKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETDTLI 1316
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKG 525
Q + A G T L ++HR++T++NC I+ M G ++E L K G
Sbjct: 1317 QRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPG 1367
Score = 127 bits (307), Expect = 2e-28
Identities = 72/235 (30%), Positives = 119/235 (50%), Gaps = 5/235 (2%)
Query: 891 VDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTV 950
++G + Q W G D Y +L GI+L + + V +VG +G GKS++
Sbjct: 1126 MEGTSCPQGWPQHGEIIFQDYHMKYRDNT-PTVLHGINLTIRGHEVVGIVGRTGSGKSSL 1184
Query: 951 LQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSR 1010
+ R +P G I +DGVDI S+ L LR +L V+ Q+P+L T+ N+ D
Sbjct: 1185 GMALFRLVEPMAGRILIDGVDIC-SIGLEDLRSKLSVIPQDPVLLSGTIRFNL---DPFD 1240
Query: 1011 KPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLL 1070
+ T + I PK T+ +Q +CIARA++R+ +++L
Sbjct: 1241 RHTDQQIWDALERTFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIIL 1300
Query: 1071 LDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVE 1125
+DEAT+++D ++ + + A +G T + IAHR+TT+ + D I V+ GK+VE
Sbjct: 1301 IDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVE 1355
Score = 111 bits (268), Expect = 1e-23
Identities = 74/220 (33%), Positives = 118/220 (53%), Gaps = 19/220 (8%)
Query: 315 LKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSS 374
L +L + G + + G++G GKS++L + +GSV + G S
Sbjct: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573
Query: 375 LGVVGQEPVLFRGTIYDNIAIG--YPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGER 432
L V Q+ + G I +NI +G Y +A V + + ++ LP G T IGER
Sbjct: 574 LAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSL---NRDLELLPFGDMTEIGER 630
Query: 433 GASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-QAALDRASVGRTTLTVS 491
G +LSGGQKQRI++AR++ + + LLD+ SA+D H K + + + + G+T + V+
Sbjct: 631 GLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVT 690
Query: 492 HRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLV 531
H+L + C +II ++ G I E GTH ELM+ KG Y +L+
Sbjct: 691 HQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI 730
Score = 72.9 bits (171), Expect = 6e-12
Identities = 59/225 (26%), Positives = 99/225 (44%), Gaps = 18/225 (8%)
Query: 924 LKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRK 983
L I+L V G + + G++G GKS++L I G++ + G
Sbjct: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------- 572
Query: 984 QLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXX 1043
L V Q+ + + ENI G K + + LP G T
Sbjct: 573 SLAYVPQQAWIVSGNIRENILMGGAYDKA---RYLQVLHCCSLNRDLELLPFGDMTEIGE 629
Query: 1044 XXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAV-TEALDHAAKGRTCITI 1102
KQR+ +ARA+ ++ LLD+ SA+DA+ + + E + +G+T + +
Sbjct: 630 RGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLV 689
Query: 1103 AHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSKQQN 1147
H+L ++ I +L+ GKI E G H+EL+ KG Y QL ++ +
Sbjct: 690 THQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMH 734
>AF367202-1|AAK58869.1| 1382|Homo sapiens ATP-binding cassette protein
C11 protein.
Length = 1382
Score = 144 bits (350), Expect = 1e-33
Identities = 76/231 (32%), Positives = 128/231 (55%), Gaps = 2/231 (0%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
GEI +D H Y + +L G +L I+ E V +VG +G GKS++ L RL +P G
Sbjct: 1139 GEIIFQDYHMKYRDNTPT-VLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAG 1197
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+ +DG ++ ++ + LRS L V+ Q+PVL GTI N+ + T + ++ E +
Sbjct: 1198 RILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLD-PFDRHTDQQIWDALERTFL 1256
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
+ I P T + E G + S G++Q + IAR++LR ++L+DEAT+++D ++ +
Sbjct: 1257 TKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETDTLI 1316
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKG 525
Q + A G T L ++HR++T++NC I+ M G ++E L K G
Sbjct: 1317 QRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPG 1367
Score = 127 bits (307), Expect = 2e-28
Identities = 72/235 (30%), Positives = 119/235 (50%), Gaps = 5/235 (2%)
Query: 891 VDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTV 950
++G + Q W G D Y +L GI+L + + V +VG +G GKS++
Sbjct: 1126 MEGTSCPQGWPQHGEIIFQDYHMKYRDNT-PTVLHGINLTIRGHEVVGIVGRTGSGKSSL 1184
Query: 951 LQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSR 1010
+ R +P G I +DGVDI S+ L LR +L V+ Q+P+L T+ N+ D
Sbjct: 1185 GMALFRLVEPMAGRILIDGVDIC-SIGLEDLRSKLSVIPQDPVLLSGTIRFNL---DPFD 1240
Query: 1011 KPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLL 1070
+ T + I PK T+ +Q +CIARA++R+ +++L
Sbjct: 1241 RHTDQQIWDALERTFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIIL 1300
Query: 1071 LDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVE 1125
+DEAT+++D ++ + + A +G T + IAHR+TT+ + D I V+ GK+VE
Sbjct: 1301 IDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVE 1355
Score = 111 bits (268), Expect = 1e-23
Identities = 74/220 (33%), Positives = 118/220 (53%), Gaps = 19/220 (8%)
Query: 315 LKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSS 374
L +L + G + + G++G GKS++L + +GSV + G S
Sbjct: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573
Query: 375 LGVVGQEPVLFRGTIYDNIAIG--YPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGER 432
L V Q+ + G I +NI +G Y +A V + + ++ LP G T IGER
Sbjct: 574 LAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSL---NRDLELLPFGDMTEIGER 630
Query: 433 GASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-QAALDRASVGRTTLTVS 491
G +LSGGQKQRI++AR++ + + LLD+ SA+D H K + + + + G+T + V+
Sbjct: 631 GLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVT 690
Query: 492 HRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLV 531
H+L + C +II ++ G I E GTH ELM+ KG Y +L+
Sbjct: 691 HQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI 730
Score = 72.9 bits (171), Expect = 6e-12
Identities = 59/225 (26%), Positives = 99/225 (44%), Gaps = 18/225 (8%)
Query: 924 LKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRK 983
L I+L V G + + G++G GKS++L I G++ + G
Sbjct: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------- 572
Query: 984 QLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXX 1043
L V Q+ + + ENI G K + + LP G T
Sbjct: 573 SLAYVPQQAWIVSGNIRENILMGGAYDKA---RYLQVLHCCSLNRDLELLPFGDMTEIGE 629
Query: 1044 XXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAV-TEALDHAAKGRTCITI 1102
KQR+ +ARA+ ++ LLD+ SA+DA+ + + E + +G+T + +
Sbjct: 630 RGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLV 689
Query: 1103 AHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSKQQN 1147
H+L ++ I +L+ GKI E G H+EL+ KG Y QL ++ +
Sbjct: 690 THQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMH 734
>AF061323-1|AAC16057.1| 1549|Homo sapiens sulfonylurea receptor 2A
protein.
Length = 1549
Score = 144 bits (350), Expect = 1e-33
Identities = 123/521 (23%), Positives = 237/521 (45%), Gaps = 29/521 (5%)
Query: 24 LCNVLSVALVSWSALKQITTIRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGM 83
LC V S+ V W L + L ++ + +FDT + ++ S + + + +
Sbjct: 1049 LCLVTSLT-VEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHI 1107
Query: 84 GEKLAVVSNLVGTSIICLCTAFPLGWKLALACITVMPFSIMASVALTNYQTKSS-IREME 142
L +L ++++CL + + + + ++P + ++ S ++E++
Sbjct: 1108 PPTL---ESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELD 1164
Query: 143 SYSQAGKQAE--EVLKSVKTVVAFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNW 200
+Q E + + T+ AF E QR L + I+ LF N W
Sbjct: 1165 DSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAY----LFLSAAN--RW 1218
Query: 201 VLTYSLNTIGFMYGTRLIIEDANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVF 260
L + +G I + + +G++ ++T + Y+ V ++
Sbjct: 1219 -LEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITNYL-----NWVVRNLADL 1272
Query: 261 ATARGAAASIFSLLDKHPK-IDCLSEAGSSPRR--VIGEISLEDVHFSYPSRSDIKILKG 317
GA + S L + + + P GEI + D+ Y + +LK
Sbjct: 1273 EVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLK-PVLKH 1331
Query: 318 FSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGV 377
+IKPG+ V + G +G GKS++ R+ D G + +DG ++ L + LRS L +
Sbjct: 1332 VKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSI 1391
Query: 378 VGQEPVLFRGTIYDNIAIGYPEA--TSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGAS 435
+ Q+P+LF G+I N+ PE T + ++ E+A +K+LP G + V+ E G +
Sbjct: 1392 ILQDPILFSGSIRFNLD---PECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGEN 1448
Query: 436 LSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLS 495
S GQ+Q +AR+ +R+ ++L++DEAT+++D +E +Q + A RT +T++HR+S
Sbjct: 1449 FSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTMAHRVS 1508
Query: 496 TIVNCHRIICMDQGTIIEQGTHVELMKAK-GFYHKLVTSGK 535
+I++ ++ +G ++E T L K G + LV + K
Sbjct: 1509 SIMDAGLVLVFSEGILVECDTVPNLFAHKNGPFSTLVMTNK 1549
Score = 126 bits (304), Expect = 5e-28
Identities = 72/236 (30%), Positives = 122/236 (51%), Gaps = 5/236 (2%)
Query: 890 TVDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKST 949
T+D + W G I+D+ Y + +LK + +++ G+ V + G +G GKS+
Sbjct: 1296 TMDPSQVPEHWPQEGEIKIHDLCVRYENNL-KPVLKHVKAYIKPGQKVGICGRTGSGKSS 1354
Query: 950 VLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNS 1009
+ R D G I +DG+DI+K L L+ LR +L ++ Q+PILF ++ N+ D
Sbjct: 1355 LSLAFFRMVDIFDGKIVIDGIDISK-LPLHTLRSRLSIILQDPILFSGSIRFNL---DPE 1410
Query: 1010 RKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLL 1069
K T D N + SLP G + +Q C+ARA +R +L
Sbjct: 1411 CKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSIL 1470
Query: 1070 LLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVE 1125
++DEAT+++D +E + + + A RT +T+AHR+++I DA ++ V +G +VE
Sbjct: 1471 IMDEATASIDMATENILQKVVMTAFADRTVVTMAHRVSSIMDAGLVLVFSEGILVE 1526
Score = 102 bits (244), Expect = 8e-21
Identities = 71/227 (31%), Positives = 112/227 (49%), Gaps = 10/227 (4%)
Query: 297 ISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSV 356
I + + +FS+ S + L + I G+ +VG GCGKS++L + +G V
Sbjct: 672 IKVTNGYFSWGS--GLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKV 729
Query: 357 KLDGRNLKTLNIGWLRS----SLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMA 412
N + RS S+ Q+P L T+ +NI G P + V +
Sbjct: 730 HWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSP-FNKQRYKAVTDAC 788
Query: 413 YAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPH-SE 471
I LP G +T IGERG +LSGGQ+QRI +AR+L + ++ LD+ SALD H S+
Sbjct: 789 SLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSD 848
Query: 472 KQVQAALDR--ASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGT 516
+Q + + RT + V+H+L + + II M G+++ +GT
Sbjct: 849 HLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGT 895
Score = 81.0 bits (191), Expect = 2e-14
Identities = 56/210 (26%), Positives = 94/210 (44%), Gaps = 9/210 (4%)
Query: 924 LKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITK---SLTLNR 980
L ID+ + G+ +VG GCGKS++L I G + V+ ++ T +R
Sbjct: 688 LSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSR 747
Query: 981 LRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETN 1040
R + Q+P L + T+ ENI +G K I LP G +T
Sbjct: 748 NRYSVAYAAQKPWLLNATVEENITFGSPFNK---QRYKAVTDACSLQPDIDLLPFGDQTE 804
Query: 1041 XXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDAN-SERAVTEALDHAAKG--R 1097
+QR+C+ARAL ++ ++ LD+ SALD + S+ + E + + R
Sbjct: 805 IGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKR 864
Query: 1098 TCITIAHRLTTIKDADIICVLDKGKIVEKG 1127
T + + H+L + AD I + G ++ +G
Sbjct: 865 TLVLVTHKLQYLTHADWIIAMKDGSVLREG 894
>AY032599-1|AAK39642.1| 1463|Homo sapiens multidrug
resistance-associated protein 7 protein.
Length = 1463
Score = 142 bits (345), Expect = 5e-33
Identities = 75/221 (33%), Positives = 132/221 (59%), Gaps = 7/221 (3%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G + +DV +Y L G + ++PGE V +VG +G GKS++L +L RL +P+ G
Sbjct: 1215 GGVEFQDVVLAYRPGLP-NALDGVTFCVQPGEKVGIVGRTGSGKSSLLLVLFRLLEPSSG 1273
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSED--VYRVAEMA 412
V LDG + L + LRS L ++ QEP LF GT+ +N+ P+ +D +++ +
Sbjct: 1274 RVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLD---PQGLHKDRALWQALKQC 1330
Query: 413 YAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEK 472
+ E I ++ G + +GE G SLS GQ+Q + +AR+LL + +L +DEAT+++D +++
Sbjct: 1331 HLSEVITSM-GGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQ 1389
Query: 473 QVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIE 513
+Q + + +T LT++HRL+TI+N R++ + ++E
Sbjct: 1390 LLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAERVVE 1430
Score = 120 bits (289), Expect = 3e-26
Identities = 70/233 (30%), Positives = 120/233 (51%), Gaps = 6/233 (2%)
Query: 900 WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYD 959
W G DV +Y L G+ V+ G+ V +VG +G GKS++L ++ R +
Sbjct: 1211 WLTQGGVEFQDVVLAYRPGLPNA-LDGVTFCVQPGEKVGIVGRTGSGKSSLLLVLFRLLE 1269
Query: 960 PTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXX 1019
P++G + LDGVD T L L +LR QL ++ QEP LF T+ EN+ + + D
Sbjct: 1270 PSSGRVLLDGVD-TSQLELAQLRSQLAIIPQEPFLFSGTVRENL----DPQGLHKDRALW 1324
Query: 1020 XXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALD 1079
+ +++ G + +Q +C+ARAL+ ++L +DEAT+++D
Sbjct: 1325 QALKQCHLSEVITSMGGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVD 1384
Query: 1080 ANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAEL 1132
+++ + + + +T +TIAHRL TI ++D + VL ++VE + A L
Sbjct: 1385 QKTDQLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAERVVELDSPATL 1437
Score = 89.0 bits (211), Expect = 8e-17
Identities = 71/273 (26%), Positives = 121/273 (44%), Gaps = 20/273 (7%)
Query: 320 LHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVG 379
L +K G V VG GCGKS++L + +G V + G L G+
Sbjct: 592 LEVKKGMLVGTVGKVGCGKSSLLAAIAGELHRLRGHVAVRG----------LSKGFGLAT 641
Query: 380 QEPVLFRGTIYDNIAIGYPEATSEDVYR-VAEMAYAHEFIKNLPNGYETVIGERGASLSG 438
QEP + TI DNI G + +Y+ V E ++ + LP G +T +GE+G +LSG
Sbjct: 642 QEPWIQFATIRDNILFG--KTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSG 699
Query: 439 GQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTT-LTVSHRLSTI 497
GQ+ RIA+AR++ +E + LLD+ +A+D + TT L +HR +
Sbjct: 700 GQRARIALARAVYQEKELYLLDDPLAAVDADVANHPLHRCILGMLSYTTRLLCTHRTEYL 759
Query: 498 VNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSGKETKEPEEIGTVLEEQETKQNGE 557
++ M+ G +I G E++ K + + +V ++TK+
Sbjct: 760 ERADAVLLMEAGRLIRAGPPPEILPLVQAVPKAWAENGQESDSATAQSVQNPEKTKE--- 816
Query: 558 LQPAVRPEPDVKRRSVRKLHRRQSAKGAHEWMA 590
+ E R +++ +++ A H + A
Sbjct: 817 ---GLEEEQSTSGRLLQEESKKEGAVALHVYQA 846
Score = 63.3 bits (147), Expect = 5e-09
Identities = 50/208 (24%), Positives = 89/208 (42%), Gaps = 15/208 (7%)
Query: 929 LHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVV 988
L V+ G V VG GCGKS++L I G++ + G L K G+
Sbjct: 592 LEVKKGMLVGTVGKVGCGKSSLLAAIAGELHRLRGHVAVRG-----------LSKGFGLA 640
Query: 989 QQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXX 1048
QEP + T+ +NI +G E ++ + LP G +T
Sbjct: 641 TQEPWIQFATIRDNILFGKTFDAQLYKEVLEACAL---NDDLSILPAGDQTEVGEKGVTL 697
Query: 1049 XXXXKQRVCIARALIRSPRLLLLDEATSALDAN-SERAVTEALDHAAKGRTCITIAHRLT 1107
+ R+ +ARA+ + L LLD+ +A+DA+ + + + T + HR
Sbjct: 698 SGGQRARIALARAVYQEKELYLLDDPLAAVDADVANHPLHRCILGMLSYTTRLLCTHRTE 757
Query: 1108 TIKDADIICVLDKGKIVEKGNHAELIGL 1135
++ AD + +++ G+++ G E++ L
Sbjct: 758 YLERADAVLLMEAGRLIRAGPPPEILPL 785
>AF071203-1|AAC27077.1| 893|Homo sapiens ABC transporter MOAT-B
isoform protein.
Length = 893
Score = 142 bits (343), Expect = 9e-33
Identities = 76/238 (31%), Positives = 139/238 (58%), Gaps = 4/238 (1%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G I ++V+F Y + +LK + IK E V +VG +G GKS+++ L RL +P +G
Sbjct: 629 GVIIFDNVNFMYSPGGPL-VLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEP-EG 686
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+ +D + + LR + ++ QEPVLF GT+ N+ + E T E+++ +
Sbjct: 687 KIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLD-PFKEHTDEELWNALQEVQL 745
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
E I++LP +T + E G++ S GQ+Q + +AR++LR+ +L++DEAT+ +DP +++ +
Sbjct: 746 KETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELI 805
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIE-QGTHVELMKAKGFYHKLV 531
Q + T LT++HRL+TI++ +I+ +D G + E +V L + ++K+V
Sbjct: 806 QKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMV 863
Score = 118 bits (285), Expect = 9e-26
Identities = 68/226 (30%), Positives = 121/226 (53%), Gaps = 6/226 (2%)
Query: 900 WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYD 959
W G ++V F Y + ++LK + +++ + V +VG +G GKS+++ + R +
Sbjct: 625 WPHEGVIIFDNVNFMY-SPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSE 683
Query: 960 PTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXX 1019
P G I +D + +T + L+ LRK++ ++ QEP+LF T+ +N+ D ++ T +E
Sbjct: 684 PE-GKIWIDKI-LTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNL---DPFKEHTDEELWN 738
Query: 1020 XXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALD 1079
I LP +T +Q VC+ARA++R ++L++DEAT+ +D
Sbjct: 739 ALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVD 798
Query: 1080 ANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVE 1125
++ + + + T +TIAHRL TI D+D I VLD G++ E
Sbjct: 799 PRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKE 844
Score = 111 bits (268), Expect = 1e-23
Identities = 74/273 (27%), Positives = 136/273 (49%), Gaps = 16/273 (5%)
Query: 299 LEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKL 358
++D + S+ L+G S ++PGE +A+VG G GKS++L + P+ G V +
Sbjct: 2 VQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSV 61
Query: 359 DGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEFI 418
GR + V Q+P +F GT+ NI G + E +V + + +
Sbjct: 62 HGR-------------IAYVSQQPWVFSGTLRSNILFG-KKYEKERYEKVIKACALKKDL 107
Query: 419 KNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-QAA 477
+ L +G TVIG+RG +LSGGQK R+ +AR++ ++ + LLD+ SA+D + + +
Sbjct: 108 QLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELC 167
Query: 478 LDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAK-GFYHKLVTSGKE 536
+ + + T+ V+H+L + +I+ + G ++++GT+ E +K+ F L +E
Sbjct: 168 ICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDNEE 227
Query: 537 TKEPEEIGTVLEEQETKQNGELQPAVRPEPDVK 569
+++P GT T + P +K
Sbjct: 228 SEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLK 260
Score = 72.1 bits (169), Expect = 1e-11
Identities = 59/225 (26%), Positives = 97/225 (43%), Gaps = 18/225 (8%)
Query: 924 LKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRK 983
L+G+ V G+ +A+VG G GKS++L + P+ G + + G
Sbjct: 18 LQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHG-------------- 63
Query: 984 QLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXX 1043
++ V Q+P +F TL NI +G K ++ + L G T
Sbjct: 64 RIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKD---LQLLEDGDLTVIGD 120
Query: 1044 XXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTE-ALDHAAKGRTCITI 1102
K RV +ARA+ + + LLD+ SA+DA R + E + + I +
Sbjct: 121 RGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILV 180
Query: 1103 AHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSKQQN 1147
H+L +K A I +L GK+V+KG + E + + L K+ N
Sbjct: 181 THQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDN 225
>AF071202-1|AAC27076.1| 1325|Homo sapiens ABC transporter MOAT-B
protein.
Length = 1325
Score = 142 bits (343), Expect = 9e-33
Identities = 76/238 (31%), Positives = 139/238 (58%), Gaps = 4/238 (1%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G I ++V+F Y + +LK + IK E V +VG +G GKS+++ L RL +P +G
Sbjct: 1039 GVIIFDNVNFMYSPGGPL-VLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEP-EG 1096
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+ +D + + LR + ++ QEPVLF GT+ N+ + E T E+++ +
Sbjct: 1097 KIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLD-PFKEHTDEELWNALQEVQL 1155
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
E I++LP +T + E G++ S GQ+Q + +AR++LR+ +L++DEAT+ +DP +++ +
Sbjct: 1156 KETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELI 1215
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIE-QGTHVELMKAKGFYHKLV 531
Q + T LT++HRL+TI++ +I+ +D G + E +V L + ++K+V
Sbjct: 1216 QKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMV 1273
Score = 118 bits (285), Expect = 9e-26
Identities = 68/226 (30%), Positives = 121/226 (53%), Gaps = 6/226 (2%)
Query: 900 WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYD 959
W G ++V F Y + ++LK + +++ + V +VG +G GKS+++ + R +
Sbjct: 1035 WPHEGVIIFDNVNFMY-SPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSE 1093
Query: 960 PTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXX 1019
P G I +D + +T + L+ LRK++ ++ QEP+LF T+ +N+ D ++ T +E
Sbjct: 1094 PE-GKIWIDKI-LTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNL---DPFKEHTDEELWN 1148
Query: 1020 XXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALD 1079
I LP +T +Q VC+ARA++R ++L++DEAT+ +D
Sbjct: 1149 ALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVD 1208
Query: 1080 ANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVE 1125
++ + + + T +TIAHRL TI D+D I VLD G++ E
Sbjct: 1209 PRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKE 1254
Score = 112 bits (270), Expect = 6e-24
Identities = 74/275 (26%), Positives = 137/275 (49%), Gaps = 16/275 (5%)
Query: 297 ISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSV 356
+ ++D + S+ L+G S ++PGE +A+VG G GKS++L + P+ G V
Sbjct: 410 VHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLV 469
Query: 357 KLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHE 416
+ GR + V Q+P +F GT+ NI G + E +V + +
Sbjct: 470 SVHGR-------------IAYVSQQPWVFSGTLRSNILFG-KKYEKERYEKVIKACALKK 515
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-Q 475
++ L +G TVIG+RG +LSGGQK R+ +AR++ ++ + LLD+ SA+D + + +
Sbjct: 516 DLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFE 575
Query: 476 AALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAK-GFYHKLVTSG 534
+ + + T+ V+H+L + +I+ + G ++++GT+ E +K+ F L
Sbjct: 576 LCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDN 635
Query: 535 KETKEPEEIGTVLEEQETKQNGELQPAVRPEPDVK 569
+E+++P GT T + P +K
Sbjct: 636 EESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLK 670
Score = 72.1 bits (169), Expect = 1e-11
Identities = 59/225 (26%), Positives = 97/225 (43%), Gaps = 18/225 (8%)
Query: 924 LKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRK 983
L+G+ V G+ +A+VG G GKS++L + P+ G + + G
Sbjct: 428 LQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHG-------------- 473
Query: 984 QLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXX 1043
++ V Q+P +F TL NI +G K ++ + L G T
Sbjct: 474 RIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKD---LQLLEDGDLTVIGD 530
Query: 1044 XXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTE-ALDHAAKGRTCITI 1102
K RV +ARA+ + + LLD+ SA+DA R + E + + I +
Sbjct: 531 RGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILV 590
Query: 1103 AHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSKQQN 1147
H+L +K A I +L GK+V+KG + E + + L K+ N
Sbjct: 591 THQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDN 635
>AY207008-1|AAO37649.1| 1325|Homo sapiens ATP-binding cassette
transporter C4 protein.
Length = 1325
Score = 141 bits (342), Expect = 1e-32
Identities = 76/238 (31%), Positives = 139/238 (58%), Gaps = 4/238 (1%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G I ++V+F Y + +LK + IK E V +VG +G GKS+++ L RL +P +G
Sbjct: 1039 GVIIFDNVNFMYSPGGPL-VLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEP-EG 1096
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+ +D + + LR + ++ QEPVLF GT+ N+ + E T E+++ +
Sbjct: 1097 KIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLD-PFNEHTDEELWNALQEVQL 1155
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
E I++LP +T + E G++ S GQ+Q + +AR++LR+ +L++DEAT+ +DP +++ +
Sbjct: 1156 KETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELI 1215
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIE-QGTHVELMKAKGFYHKLV 531
Q + T LT++HRL+TI++ +I+ +D G + E +V L + ++K+V
Sbjct: 1216 QKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMV 1273
Score = 118 bits (283), Expect = 2e-25
Identities = 68/226 (30%), Positives = 120/226 (53%), Gaps = 6/226 (2%)
Query: 900 WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYD 959
W G ++V F Y + ++LK + +++ + V +VG +G GKS+++ + R +
Sbjct: 1035 WPHEGVIIFDNVNFMY-SPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSE 1093
Query: 960 PTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXX 1019
P G I +D + +T + L+ LRK++ ++ QEP+LF T+ +N+ D + T +E
Sbjct: 1094 PE-GKIWIDKI-LTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNL---DPFNEHTDEELWN 1148
Query: 1020 XXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALD 1079
I LP +T +Q VC+ARA++R ++L++DEAT+ +D
Sbjct: 1149 ALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVD 1208
Query: 1080 ANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVE 1125
++ + + + T +TIAHRL TI D+D I VLD G++ E
Sbjct: 1209 PRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKE 1254
Score = 112 bits (270), Expect = 6e-24
Identities = 74/275 (26%), Positives = 137/275 (49%), Gaps = 16/275 (5%)
Query: 297 ISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSV 356
+ ++D + S+ L+G S ++PGE +A+VG G GKS++L + P+ G V
Sbjct: 410 VHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLV 469
Query: 357 KLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHE 416
+ GR + V Q+P +F GT+ NI G + E +V + +
Sbjct: 470 SVHGR-------------IAYVSQQPWVFSGTLRSNILFG-KKYEKERYEKVIKACALKK 515
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-Q 475
++ L +G TVIG+RG +LSGGQK R+ +AR++ ++ + LLD+ SA+D + + +
Sbjct: 516 DLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFE 575
Query: 476 AALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAK-GFYHKLVTSG 534
+ + + T+ V+H+L + +I+ + G ++++GT+ E +K+ F L
Sbjct: 576 LCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDN 635
Query: 535 KETKEPEEIGTVLEEQETKQNGELQPAVRPEPDVK 569
+E+++P GT T + P +K
Sbjct: 636 EESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLK 670
Score = 72.1 bits (169), Expect = 1e-11
Identities = 59/225 (26%), Positives = 97/225 (43%), Gaps = 18/225 (8%)
Query: 924 LKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRK 983
L+G+ V G+ +A+VG G GKS++L + P+ G + + G
Sbjct: 428 LQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHG-------------- 473
Query: 984 QLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXX 1043
++ V Q+P +F TL NI +G K ++ + L G T
Sbjct: 474 RIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKD---LQLLEDGDLTVIGD 530
Query: 1044 XXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTE-ALDHAAKGRTCITI 1102
K RV +ARA+ + + LLD+ SA+DA R + E + + I +
Sbjct: 531 RGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILV 590
Query: 1103 AHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSKQQN 1147
H+L +K A I +L GK+V+KG + E + + L K+ N
Sbjct: 591 THQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDN 635
>AY081219-1|AAL88745.1| 1325|Homo sapiens multidrug
resistance-associated protein protein.
Length = 1325
Score = 141 bits (342), Expect = 1e-32
Identities = 76/238 (31%), Positives = 139/238 (58%), Gaps = 4/238 (1%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G I ++V+F Y + +LK + IK E V +VG +G GKS+++ L RL +P +G
Sbjct: 1039 GVIIFDNVNFMYSPGGPL-VLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEP-EG 1096
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+ +D + + LR + ++ QEPVLF GT+ N+ + E T E+++ +
Sbjct: 1097 KIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLD-PFNEHTDEELWNALQEVQL 1155
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
E I++LP +T + E G++ S GQ+Q + +AR++LR+ +L++DEAT+ +DP +++ +
Sbjct: 1156 KETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELI 1215
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIE-QGTHVELMKAKGFYHKLV 531
Q + T LT++HRL+TI++ +I+ +D G + E +V L + ++K+V
Sbjct: 1216 QKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMV 1273
Score = 118 bits (283), Expect = 2e-25
Identities = 68/226 (30%), Positives = 120/226 (53%), Gaps = 6/226 (2%)
Query: 900 WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYD 959
W G ++V F Y + ++LK + +++ + V +VG +G GKS+++ + R +
Sbjct: 1035 WPHEGVIIFDNVNFMY-SPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSE 1093
Query: 960 PTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXX 1019
P G I +D + +T + L+ LRK++ ++ QEP+LF T+ +N+ D + T +E
Sbjct: 1094 PE-GKIWIDKI-LTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNL---DPFNEHTDEELWN 1148
Query: 1020 XXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALD 1079
I LP +T +Q VC+ARA++R ++L++DEAT+ +D
Sbjct: 1149 ALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVD 1208
Query: 1080 ANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVE 1125
++ + + + T +TIAHRL TI D+D I VLD G++ E
Sbjct: 1209 PRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKE 1254
Score = 112 bits (270), Expect = 6e-24
Identities = 74/275 (26%), Positives = 137/275 (49%), Gaps = 16/275 (5%)
Query: 297 ISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSV 356
+ ++D + S+ L+G S ++PGE +A+VG G GKS++L + P+ G V
Sbjct: 410 VHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLV 469
Query: 357 KLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHE 416
+ GR + V Q+P +F GT+ NI G + E +V + +
Sbjct: 470 SVHGR-------------IAYVSQQPWVFSGTLRSNILFG-KKYEKERYEKVIKACALKK 515
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-Q 475
++ L +G TVIG+RG +LSGGQK R+ +AR++ ++ + LLD+ SA+D + + +
Sbjct: 516 DLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFE 575
Query: 476 AALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAK-GFYHKLVTSG 534
+ + + T+ V+H+L + +I+ + G ++++GT+ E +K+ F L
Sbjct: 576 LCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDN 635
Query: 535 KETKEPEEIGTVLEEQETKQNGELQPAVRPEPDVK 569
+E+++P GT T + P +K
Sbjct: 636 EESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLK 670
Score = 72.1 bits (169), Expect = 1e-11
Identities = 59/225 (26%), Positives = 97/225 (43%), Gaps = 18/225 (8%)
Query: 924 LKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRK 983
L+G+ V G+ +A+VG G GKS++L + P+ G + + G
Sbjct: 428 LQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHG-------------- 473
Query: 984 QLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXX 1043
++ V Q+P +F TL NI +G K ++ + L G T
Sbjct: 474 RIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKD---LQLLEDGDLTVIGD 530
Query: 1044 XXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTE-ALDHAAKGRTCITI 1102
K RV +ARA+ + + LLD+ SA+DA R + E + + I +
Sbjct: 531 RGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILV 590
Query: 1103 AHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSKQQN 1147
H+L +K A I +L GK+V+KG + E + + L K+ N
Sbjct: 591 THQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDN 635
>AL356257-1|CAI16722.1| 1325|Homo sapiens ATP-binding cassette,
sub-family C (CFTR/MRP), member 4 protein.
Length = 1325
Score = 141 bits (342), Expect = 1e-32
Identities = 76/238 (31%), Positives = 139/238 (58%), Gaps = 4/238 (1%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G I ++V+F Y + +LK + IK E V +VG +G GKS+++ L RL +P +G
Sbjct: 1039 GVIIFDNVNFMYSPGGPL-VLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEP-EG 1096
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+ +D + + LR + ++ QEPVLF GT+ N+ + E T E+++ +
Sbjct: 1097 KIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLD-PFNEHTDEELWNALQEVQL 1155
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
E I++LP +T + E G++ S GQ+Q + +AR++LR+ +L++DEAT+ +DP +++ +
Sbjct: 1156 KETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELI 1215
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIE-QGTHVELMKAKGFYHKLV 531
Q + T LT++HRL+TI++ +I+ +D G + E +V L + ++K+V
Sbjct: 1216 QKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMV 1273
Score = 118 bits (283), Expect = 2e-25
Identities = 68/226 (30%), Positives = 120/226 (53%), Gaps = 6/226 (2%)
Query: 900 WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYD 959
W G ++V F Y + ++LK + +++ + V +VG +G GKS+++ + R +
Sbjct: 1035 WPHEGVIIFDNVNFMY-SPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSE 1093
Query: 960 PTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXX 1019
P G I +D + +T + L+ LRK++ ++ QEP+LF T+ +N+ D + T +E
Sbjct: 1094 PE-GKIWIDKI-LTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNL---DPFNEHTDEELWN 1148
Query: 1020 XXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALD 1079
I LP +T +Q VC+ARA++R ++L++DEAT+ +D
Sbjct: 1149 ALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVD 1208
Query: 1080 ANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVE 1125
++ + + + T +TIAHRL TI D+D I VLD G++ E
Sbjct: 1209 PRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKE 1254
Score = 112 bits (270), Expect = 6e-24
Identities = 74/275 (26%), Positives = 137/275 (49%), Gaps = 16/275 (5%)
Query: 297 ISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSV 356
+ ++D + S+ L+G S ++PGE +A+VG G GKS++L + P+ G V
Sbjct: 410 VHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLV 469
Query: 357 KLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHE 416
+ GR + V Q+P +F GT+ NI G + E +V + +
Sbjct: 470 SVHGR-------------IAYVSQQPWVFSGTLRSNILFG-KKYEKERYEKVIKACALKK 515
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-Q 475
++ L +G TVIG+RG +LSGGQK R+ +AR++ ++ + LLD+ SA+D + + +
Sbjct: 516 DLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFE 575
Query: 476 AALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAK-GFYHKLVTSG 534
+ + + T+ V+H+L + +I+ + G ++++GT+ E +K+ F L
Sbjct: 576 LCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDN 635
Query: 535 KETKEPEEIGTVLEEQETKQNGELQPAVRPEPDVK 569
+E+++P GT T + P +K
Sbjct: 636 EESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLK 670
Score = 72.1 bits (169), Expect = 1e-11
Identities = 59/225 (26%), Positives = 97/225 (43%), Gaps = 18/225 (8%)
Query: 924 LKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRK 983
L+G+ V G+ +A+VG G GKS++L + P+ G + + G
Sbjct: 428 LQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHG-------------- 473
Query: 984 QLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXX 1043
++ V Q+P +F TL NI +G K ++ + L G T
Sbjct: 474 RIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKD---LQLLEDGDLTVIGD 530
Query: 1044 XXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTE-ALDHAAKGRTCITI 1102
K RV +ARA+ + + LLD+ SA+DA R + E + + I +
Sbjct: 531 RGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILV 590
Query: 1103 AHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSKQQN 1147
H+L +K A I +L GK+V+KG + E + + L K+ N
Sbjct: 591 THQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDN 635
>AL157818-1|CAC36037.2| 1325|Homo sapiens ATP-binding cassette,
sub-family C (CFTR/MRP), member 4 protein.
Length = 1325
Score = 141 bits (342), Expect = 1e-32
Identities = 76/238 (31%), Positives = 139/238 (58%), Gaps = 4/238 (1%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G I ++V+F Y + +LK + IK E V +VG +G GKS+++ L RL +P +G
Sbjct: 1039 GVIIFDNVNFMYSPGGPL-VLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEP-EG 1096
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+ +D + + LR + ++ QEPVLF GT+ N+ + E T E+++ +
Sbjct: 1097 KIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLD-PFNEHTDEELWNALQEVQL 1155
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
E I++LP +T + E G++ S GQ+Q + +AR++LR+ +L++DEAT+ +DP +++ +
Sbjct: 1156 KETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELI 1215
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIE-QGTHVELMKAKGFYHKLV 531
Q + T LT++HRL+TI++ +I+ +D G + E +V L + ++K+V
Sbjct: 1216 QKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMV 1273
Score = 118 bits (283), Expect = 2e-25
Identities = 68/226 (30%), Positives = 120/226 (53%), Gaps = 6/226 (2%)
Query: 900 WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYD 959
W G ++V F Y + ++LK + +++ + V +VG +G GKS+++ + R +
Sbjct: 1035 WPHEGVIIFDNVNFMY-SPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSE 1093
Query: 960 PTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXX 1019
P G I +D + +T + L+ LRK++ ++ QEP+LF T+ +N+ D + T +E
Sbjct: 1094 PE-GKIWIDKI-LTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNL---DPFNEHTDEELWN 1148
Query: 1020 XXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALD 1079
I LP +T +Q VC+ARA++R ++L++DEAT+ +D
Sbjct: 1149 ALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVD 1208
Query: 1080 ANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVE 1125
++ + + + T +TIAHRL TI D+D I VLD G++ E
Sbjct: 1209 PRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKE 1254
Score = 112 bits (270), Expect = 6e-24
Identities = 74/275 (26%), Positives = 137/275 (49%), Gaps = 16/275 (5%)
Query: 297 ISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSV 356
+ ++D + S+ L+G S ++PGE +A+VG G GKS++L + P+ G V
Sbjct: 410 VHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLV 469
Query: 357 KLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHE 416
+ GR + V Q+P +F GT+ NI G + E +V + +
Sbjct: 470 SVHGR-------------IAYVSQQPWVFSGTLRSNILFG-KKYEKERYEKVIKACALKK 515
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-Q 475
++ L +G TVIG+RG +LSGGQK R+ +AR++ ++ + LLD+ SA+D + + +
Sbjct: 516 DLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFE 575
Query: 476 AALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAK-GFYHKLVTSG 534
+ + + T+ V+H+L + +I+ + G ++++GT+ E +K+ F L
Sbjct: 576 LCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDN 635
Query: 535 KETKEPEEIGTVLEEQETKQNGELQPAVRPEPDVK 569
+E+++P GT T + P +K
Sbjct: 636 EESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLK 670
Score = 72.1 bits (169), Expect = 1e-11
Identities = 59/225 (26%), Positives = 97/225 (43%), Gaps = 18/225 (8%)
Query: 924 LKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRK 983
L+G+ V G+ +A+VG G GKS++L + P+ G + + G
Sbjct: 428 LQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHG-------------- 473
Query: 984 QLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXX 1043
++ V Q+P +F TL NI +G K ++ + L G T
Sbjct: 474 RIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKD---LQLLEDGDLTVIGD 530
Query: 1044 XXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTE-ALDHAAKGRTCITI 1102
K RV +ARA+ + + LLD+ SA+DA R + E + + I +
Sbjct: 531 RGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILV 590
Query: 1103 AHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSKQQN 1147
H+L +K A I +L GK+V+KG + E + + L K+ N
Sbjct: 591 THQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDN 635
>AL139381-1|CAI16589.1| 1325|Homo sapiens ATP-binding cassette,
sub-family C (CFTR/MRP), member 4 protein.
Length = 1325
Score = 141 bits (342), Expect = 1e-32
Identities = 76/238 (31%), Positives = 139/238 (58%), Gaps = 4/238 (1%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G I ++V+F Y + +LK + IK E V +VG +G GKS+++ L RL +P +G
Sbjct: 1039 GVIIFDNVNFMYSPGGPL-VLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEP-EG 1096
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+ +D + + LR + ++ QEPVLF GT+ N+ + E T E+++ +
Sbjct: 1097 KIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLD-PFNEHTDEELWNALQEVQL 1155
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
E I++LP +T + E G++ S GQ+Q + +AR++LR+ +L++DEAT+ +DP +++ +
Sbjct: 1156 KETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELI 1215
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIE-QGTHVELMKAKGFYHKLV 531
Q + T LT++HRL+TI++ +I+ +D G + E +V L + ++K+V
Sbjct: 1216 QKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMV 1273
Score = 118 bits (283), Expect = 2e-25
Identities = 68/226 (30%), Positives = 120/226 (53%), Gaps = 6/226 (2%)
Query: 900 WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYD 959
W G ++V F Y + ++LK + +++ + V +VG +G GKS+++ + R +
Sbjct: 1035 WPHEGVIIFDNVNFMY-SPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSE 1093
Query: 960 PTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXX 1019
P G I +D + +T + L+ LRK++ ++ QEP+LF T+ +N+ D + T +E
Sbjct: 1094 PE-GKIWIDKI-LTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNL---DPFNEHTDEELWN 1148
Query: 1020 XXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALD 1079
I LP +T +Q VC+ARA++R ++L++DEAT+ +D
Sbjct: 1149 ALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVD 1208
Query: 1080 ANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVE 1125
++ + + + T +TIAHRL TI D+D I VLD G++ E
Sbjct: 1209 PRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKE 1254
Score = 112 bits (270), Expect = 6e-24
Identities = 74/275 (26%), Positives = 137/275 (49%), Gaps = 16/275 (5%)
Query: 297 ISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSV 356
+ ++D + S+ L+G S ++PGE +A+VG G GKS++L + P+ G V
Sbjct: 410 VHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLV 469
Query: 357 KLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHE 416
+ GR + V Q+P +F GT+ NI G + E +V + +
Sbjct: 470 SVHGR-------------IAYVSQQPWVFSGTLRSNILFG-KKYEKERYEKVIKACALKK 515
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-Q 475
++ L +G TVIG+RG +LSGGQK R+ +AR++ ++ + LLD+ SA+D + + +
Sbjct: 516 DLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFE 575
Query: 476 AALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAK-GFYHKLVTSG 534
+ + + T+ V+H+L + +I+ + G ++++GT+ E +K+ F L
Sbjct: 576 LCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDN 635
Query: 535 KETKEPEEIGTVLEEQETKQNGELQPAVRPEPDVK 569
+E+++P GT T + P +K
Sbjct: 636 EESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLK 670
Score = 72.1 bits (169), Expect = 1e-11
Identities = 59/225 (26%), Positives = 97/225 (43%), Gaps = 18/225 (8%)
Query: 924 LKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRK 983
L+G+ V G+ +A+VG G GKS++L + P+ G + + G
Sbjct: 428 LQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHG-------------- 473
Query: 984 QLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXX 1043
++ V Q+P +F TL NI +G K ++ + L G T
Sbjct: 474 RIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKD---LQLLEDGDLTVIGD 530
Query: 1044 XXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTE-ALDHAAKGRTCITI 1102
K RV +ARA+ + + LLD+ SA+DA R + E + + I +
Sbjct: 531 RGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILV 590
Query: 1103 AHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSKQQN 1147
H+L +K A I +L GK+V+KG + E + + L K+ N
Sbjct: 591 THQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDN 635
>AF541977-1|AAN17334.1| 1278|Homo sapiens ATP-binding cassette protein
C4 splice variant A protein.
Length = 1278
Score = 141 bits (342), Expect = 1e-32
Identities = 76/238 (31%), Positives = 139/238 (58%), Gaps = 4/238 (1%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G I ++V+F Y + +LK + IK E V +VG +G GKS+++ L RL +P +G
Sbjct: 992 GVIIFDNVNFMYSPGGPL-VLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEP-EG 1049
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+ +D + + LR + ++ QEPVLF GT+ N+ + E T E+++ +
Sbjct: 1050 KIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLD-PFNEHTDEELWNALQEVQL 1108
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
E I++LP +T + E G++ S GQ+Q + +AR++LR+ +L++DEAT+ +DP +++ +
Sbjct: 1109 KETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELI 1168
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIE-QGTHVELMKAKGFYHKLV 531
Q + T LT++HRL+TI++ +I+ +D G + E +V L + ++K+V
Sbjct: 1169 QKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMV 1226
Score = 118 bits (283), Expect = 2e-25
Identities = 68/226 (30%), Positives = 120/226 (53%), Gaps = 6/226 (2%)
Query: 900 WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYD 959
W G ++V F Y + ++LK + +++ + V +VG +G GKS+++ + R +
Sbjct: 988 WPHEGVIIFDNVNFMY-SPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSE 1046
Query: 960 PTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXX 1019
P G I +D + +T + L+ LRK++ ++ QEP+LF T+ +N+ D + T +E
Sbjct: 1047 PE-GKIWIDKI-LTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNL---DPFNEHTDEELWN 1101
Query: 1020 XXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALD 1079
I LP +T +Q VC+ARA++R ++L++DEAT+ +D
Sbjct: 1102 ALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVD 1161
Query: 1080 ANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVE 1125
++ + + + T +TIAHRL TI D+D I VLD G++ E
Sbjct: 1162 PRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKE 1207
Score = 112 bits (270), Expect = 6e-24
Identities = 74/275 (26%), Positives = 137/275 (49%), Gaps = 16/275 (5%)
Query: 297 ISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSV 356
+ ++D + S+ L+G S ++PGE +A+VG G GKS++L + P+ G V
Sbjct: 410 VHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLV 469
Query: 357 KLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHE 416
+ GR + V Q+P +F GT+ NI G + E +V + +
Sbjct: 470 SVHGR-------------IAYVSQQPWVFSGTLRSNILFG-KKYEKERYEKVIKACALKK 515
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-Q 475
++ L +G TVIG+RG +LSGGQK R+ +AR++ ++ + LLD+ SA+D + + +
Sbjct: 516 DLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFE 575
Query: 476 AALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAK-GFYHKLVTSG 534
+ + + T+ V+H+L + +I+ + G ++++GT+ E +K+ F L
Sbjct: 576 LCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDN 635
Query: 535 KETKEPEEIGTVLEEQETKQNGELQPAVRPEPDVK 569
+E+++P GT T + P +K
Sbjct: 636 EESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLK 670
Score = 72.1 bits (169), Expect = 1e-11
Identities = 59/225 (26%), Positives = 97/225 (43%), Gaps = 18/225 (8%)
Query: 924 LKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRK 983
L+G+ V G+ +A+VG G GKS++L + P+ G + + G
Sbjct: 428 LQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHG-------------- 473
Query: 984 QLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXX 1043
++ V Q+P +F TL NI +G K ++ + L G T
Sbjct: 474 RIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKD---LQLLEDGDLTVIGD 530
Query: 1044 XXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTE-ALDHAAKGRTCITI 1102
K RV +ARA+ + + LLD+ SA+DA R + E + + I +
Sbjct: 531 RGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILV 590
Query: 1103 AHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSKQQN 1147
H+L +K A I +L GK+V+KG + E + + L K+ N
Sbjct: 591 THQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDN 635
>AJ294545-1|CAC69553.1| 1514|Homo sapiens multidrug resistance
associated protein protein.
Length = 1514
Score = 139 bits (336), Expect = 6e-32
Identities = 75/234 (32%), Positives = 136/234 (58%), Gaps = 15/234 (6%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
GE+ + Y D+ +L+ SLH+ GE V +VG +G GKS++ L R+ + +G
Sbjct: 1287 GEVEFRNYSVRYRPGLDL-VLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKG 1345
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+++DG N+ +IG +P+LF GT+ N+ + + ED++ E+++
Sbjct: 1346 EIRIDGLNVA--DIG-----------DPILFSGTLRMNLD-PFGSYSEEDIWWALELSHL 1391
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
H F+ + P G + E G +LS GQ+Q + +AR+LLR+ +L+LDEAT+A+D ++ +
Sbjct: 1392 HTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLI 1451
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYH 528
QA + T LT++HRL+TI++ R++ +D+G + E + L+ A+G ++
Sbjct: 1452 QATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIFY 1505
Score = 116 bits (280), Expect = 4e-25
Identities = 74/255 (29%), Positives = 121/255 (47%), Gaps = 20/255 (7%)
Query: 891 VDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTV 950
V+G + W G + Y ++L+ + LHV G+ V +VG +G GKS++
Sbjct: 1274 VEGSRPPEGWPPRGEVEFRNYSVRYRPGL-DLVLRDLSLHVHGGEKVGIVGRTGAGKSSM 1332
Query: 951 LQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENI-AYGDNS 1009
+ R + G I +DG+++ +G +PILF TL N+ +G S
Sbjct: 1333 TLCLFRILEAAKGEIRIDGLNVA----------DIG----DPILFSGTLRMNLDPFGSYS 1378
Query: 1010 RKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLL 1069
++ H F+ S P G + +Q VC+ARAL+R R+L
Sbjct: 1379 E----EDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRIL 1434
Query: 1070 LLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNH 1129
+LDEAT+A+D ++ + + T +TIAHRL TI D + VLDKG + E +
Sbjct: 1435 VLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSP 1494
Query: 1130 AELIGLKGHYWQLSK 1144
A LI +G ++ +++
Sbjct: 1495 ANLIAARGIFYGMAR 1509
Score = 91.1 bits (216), Expect = 2e-17
Identities = 67/247 (27%), Positives = 119/247 (48%), Gaps = 22/247 (8%)
Query: 315 LKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSS 374
L + + G VA+VG GCGKS+++ L + +G V + G S
Sbjct: 644 LHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKG-------------S 690
Query: 375 LGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYR-VAEMAYAHEFIKNLPNGYETVIGERG 433
+ V Q+ + T+ +N+ G +A + Y+ E ++ LP G +T IGE+G
Sbjct: 691 VAYVPQQAWIQNCTLQENVLFG--KALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKG 748
Query: 434 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV---QAALDRASVGRTTLTV 490
+LSGGQ+QR+++AR++ + + LLD+ SA+D H K + + G+T + V
Sbjct: 749 INLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLV 808
Query: 491 SHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTS---GKETKEPEEIGTVL 547
+H +S + II + G + E G + L++ G + + + ++ E+ T L
Sbjct: 809 THGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTAL 868
Query: 548 EEQETKQ 554
E E K+
Sbjct: 869 EGAEDKE 875
Score = 66.1 bits (154), Expect = 7e-10
Identities = 50/219 (22%), Positives = 93/219 (42%), Gaps = 20/219 (9%)
Query: 924 LKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRK 983
L +D+ V G VA+VG GCGKS+++ + + G + + G
Sbjct: 644 LHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKG-------------- 689
Query: 984 QLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXX 1043
+ V Q+ + + TL EN+ +G + + LP G +T
Sbjct: 690 SVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLAD---LEMLPGGDQTEIGE 746
Query: 1044 XXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEAL---DHAAKGRTCI 1100
+QRV +ARA+ + LLD+ SA+D++ + + + + + G+T +
Sbjct: 747 KGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRV 806
Query: 1101 TIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHY 1139
+ H ++ + D I VL G++ E G + L+ G +
Sbjct: 807 LVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSF 845
>AY851364-1|AAW31629.1| 131|Homo sapiens ABCB5alpha protein.
Length = 131
Score = 136 bits (328), Expect = 6e-31
Identities = 65/123 (52%), Positives = 88/123 (71%)
Query: 358 LDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEF 417
+D +++ LN+ R +GVV QEPVLF TI +NI G + T E++ R A A A++F
Sbjct: 2 VDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDF 61
Query: 418 IKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAA 477
I PN + T++GE+GA +SGGQKQRIAIAR+L+R P +L+LDEATSALD SE VQAA
Sbjct: 62 IMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESESAVQAA 121
Query: 478 LDR 480
L++
Sbjct: 122 LEK 124
Score = 92.3 bits (219), Expect = 9e-18
Identities = 50/125 (40%), Positives = 72/125 (57%), Gaps = 3/125 (2%)
Query: 967 LDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXX 1026
+D DI ++L + R +GVV QEP+LF T++ NI YG + T +E
Sbjct: 2 VDENDI-RALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDD--VTDEEMERAAREANA 58
Query: 1027 HNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAV 1086
++FI+ P + T KQR+ IARAL+R+P++L+LDEATSALD+ SE AV
Sbjct: 59 YDFIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESESAV 118
Query: 1087 TEALD 1091
AL+
Sbjct: 119 QAALE 123
>L40625-1|AAA99227.1| 395|Homo sapiens sulfonylurea receptor
protein.
Length = 395
Score = 132 bits (319), Expect = 7e-30
Identities = 74/232 (31%), Positives = 131/232 (56%), Gaps = 6/232 (2%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G+I ++++ Y S S +LK + I PG+ + + G +G GKS+ R+ D +G
Sbjct: 156 GKIQIQNLSVRYDS-SLKPVLKHVNALISPGQKIGICGRTGSGKSSFSLAFFRMVDTFEG 214
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSED--VYRVAEMA 412
+ +DG ++ L + LRS L ++ Q+PVLF GTI N+ PE D ++ E+A
Sbjct: 215 HIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLD---PERKCSDSTLWEALEIA 271
Query: 413 YAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEK 472
+K LP G + +I E G + S GQ+Q +AR+ +R+ ++ ++DEAT+++D +E
Sbjct: 272 QLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATEN 331
Query: 473 QVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAK 524
+Q + A RT +T++HR+ TI++ +I + +G I+E +L+ K
Sbjct: 332 ILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRK 383
Score = 119 bits (287), Expect = 5e-26
Identities = 69/239 (28%), Positives = 120/239 (50%), Gaps = 5/239 (2%)
Query: 898 QDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRF 957
++W G I ++ Y + + +LK ++ + G+ + + G +G GKS+ R
Sbjct: 150 KNWPDQGKIQIQNLSVRYDSSL-KPVLKHVNALISPGQKIGICGRTGSGKSSFSLAFFRM 208
Query: 958 YDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEX 1017
D G+I +DG+DI K L L+ LR +L ++ Q+P+LF T+ N+ D RK +
Sbjct: 209 VDTFEGHIIIDGIDIAK-LPLHTLRSRLSIILQDPVLFSGTIRFNL---DPERKCSDSTL 264
Query: 1018 XXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSA 1077
+ +LP G + +Q C+ARA +R + ++DEAT++
Sbjct: 265 WEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATAS 324
Query: 1078 LDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLK 1136
+D +E + + + A RT +TIAHR+ TI AD++ VL +G I+E +L+ K
Sbjct: 325 IDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRK 383
>AL122095-1|CAB59263.1| 216|Homo sapiens hypothetical protein
protein.
Length = 216
Score = 132 bits (318), Expect = 9e-30
Identities = 69/210 (32%), Positives = 127/210 (60%), Gaps = 7/210 (3%)
Query: 330 LVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTI 389
+VG +G GKS++L +L RL +P+ G V LDG + L + LRS L ++ QEP LF GT+
Sbjct: 2 IVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSGTV 61
Query: 390 YDNIAIGYPEATSED--VYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIA 447
+N+ P+ +D +++ + + E I ++ G + +GE G SLS GQ+Q + +A
Sbjct: 62 RENLD---PQGLHKDRALWQALKQCHLSEVITSM-GGLDGELGEGGRSLSLGQRQLLCLA 117
Query: 448 RSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMD 507
R+LL + +L +DEAT+++D +++ +Q + + +T LT++HRL+TI+N R++ +
Sbjct: 118 RALLTDAKILCIDEATASVDQKTDQLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQ 177
Query: 508 QGTIIEQGTHVELM-KAKGFYHKLVTSGKE 536
G ++E + L + + +L+ S ++
Sbjct: 178 AGRVVELDSPATLRNQPHSLFQQLLQSSQQ 207
Score = 110 bits (264), Expect = 3e-23
Identities = 61/194 (31%), Positives = 107/194 (55%), Gaps = 5/194 (2%)
Query: 939 LVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRT 998
+VG +G GKS++L ++ R +P++G + LDGVD T L L +LR QL ++ QEP LF T
Sbjct: 2 IVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVD-TSQLELAQLRSQLAIIPQEPFLFSGT 60
Query: 999 LAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCI 1058
+ EN+ + + D + +++ G + +Q +C+
Sbjct: 61 VRENL----DPQGLHKDRALWQALKQCHLSEVITSMGGLDGELGEGGRSLSLGQRQLLCL 116
Query: 1059 ARALIRSPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVL 1118
ARAL+ ++L +DEAT+++D +++ + + + +T +TIAHRL TI ++D + VL
Sbjct: 117 ARALLTDAKILCIDEATASVDQKTDQLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVL 176
Query: 1119 DKGKIVEKGNHAEL 1132
G++VE + A L
Sbjct: 177 QAGRVVELDSPATL 190
>AF411578-1|AAL99901.1| 1009|Homo sapiens ATP-binding cassette
protein C12 isoform D protein.
Length = 1009
Score = 126 bits (305), Expect = 3e-28
Identities = 86/277 (31%), Positives = 143/277 (51%), Gaps = 25/277 (9%)
Query: 314 ILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRS 373
+L S ++ G+ + + G+ G GKS++L L +G V ++G
Sbjct: 495 VLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNG------------- 541
Query: 374 SLGVVGQEPVLFRGTIYDNIAIG--YPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGE 431
+L V Q+ +F G + +NI G Y + RV + + + NLP G T IGE
Sbjct: 542 TLAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGL---QKDLSNLPYGDLTEIGE 598
Query: 432 RGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-QAALDRASVGRTTLTV 490
RG +LSGGQ+QRI++AR++ + + LLD+ SA+D H K V + + + G+T + V
Sbjct: 599 RGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLV 658
Query: 491 SHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTS--GKETKEPEEIGTVLE 548
+H+L + +C +I ++ G I E+GTH ELM+ +G Y KL+ + G + K+PE +
Sbjct: 659 THQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDPEHLYNAAM 718
Query: 549 EQETKQNGELQPAVRPEPDVKRRSVRKLHRRQSAKGA 585
+ K++ PA R E V K ++S G+
Sbjct: 719 VEAFKES----PAEREEDAVLAPGNEKDEGKESETGS 751
Score = 78.6 bits (185), Expect = 1e-13
Identities = 58/221 (26%), Positives = 99/221 (44%), Gaps = 18/221 (8%)
Query: 923 ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLR 982
+L I V GK + + G+ G GKS++L + G + ++G
Sbjct: 495 VLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGT------------ 542
Query: 983 KQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXX 1042
L V Q+ +F + ENI +G+ K + +LP G T
Sbjct: 543 --LAYVSQQAWIFHGNVRENILFGE---KYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIG 597
Query: 1043 XXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAV-TEALDHAAKGRTCIT 1101
+QR+ +ARA+ +L LLD+ SA+DA+ + V E + +G+T +
Sbjct: 598 ERGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVL 657
Query: 1102 IAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQL 1142
+ H+L ++ D + +L+ G+I EKG H EL+ +G Y +L
Sbjct: 658 VTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKL 698
>AF411577-1|AAL99900.1| 1009|Homo sapiens ATP-binding cassette
protein C12 isoform C-p1 protein.
Length = 1009
Score = 126 bits (305), Expect = 3e-28
Identities = 86/277 (31%), Positives = 143/277 (51%), Gaps = 25/277 (9%)
Query: 314 ILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRS 373
+L S ++ G+ + + G+ G GKS++L L +G V ++G
Sbjct: 495 VLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNG------------- 541
Query: 374 SLGVVGQEPVLFRGTIYDNIAIG--YPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGE 431
+L V Q+ +F G + +NI G Y + RV + + + NLP G T IGE
Sbjct: 542 TLAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGL---QKDLSNLPYGDLTEIGE 598
Query: 432 RGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-QAALDRASVGRTTLTV 490
RG +LSGGQ+QRI++AR++ + + LLD+ SA+D H K V + + + G+T + V
Sbjct: 599 RGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLV 658
Query: 491 SHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTS--GKETKEPEEIGTVLE 548
+H+L + +C +I ++ G I E+GTH ELM+ +G Y KL+ + G + K+PE +
Sbjct: 659 THQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDPEHLYNAAM 718
Query: 549 EQETKQNGELQPAVRPEPDVKRRSVRKLHRRQSAKGA 585
+ K++ PA R E V K ++S G+
Sbjct: 719 VEAFKES----PAEREEDAVLAPGNEKDEGKESETGS 751
Score = 78.6 bits (185), Expect = 1e-13
Identities = 58/221 (26%), Positives = 99/221 (44%), Gaps = 18/221 (8%)
Query: 923 ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLR 982
+L I V GK + + G+ G GKS++L + G + ++G
Sbjct: 495 VLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGT------------ 542
Query: 983 KQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXX 1042
L V Q+ +F + ENI +G+ K + +LP G T
Sbjct: 543 --LAYVSQQAWIFHGNVRENILFGE---KYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIG 597
Query: 1043 XXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAV-TEALDHAAKGRTCIT 1101
+QR+ +ARA+ +L LLD+ SA+DA+ + V E + +G+T +
Sbjct: 598 ERGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVL 657
Query: 1102 IAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQL 1142
+ H+L ++ D + +L+ G+I EKG H EL+ +G Y +L
Sbjct: 658 VTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKL 698
>AF395909-1|AAL79529.1| 935|Homo sapiens ATP-binding cassette
protein C12 isoform B protein.
Length = 935
Score = 126 bits (305), Expect = 3e-28
Identities = 86/277 (31%), Positives = 143/277 (51%), Gaps = 25/277 (9%)
Query: 314 ILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRS 373
+L S ++ G+ + + G+ G GKS++L L +G V ++G
Sbjct: 495 VLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNG------------- 541
Query: 374 SLGVVGQEPVLFRGTIYDNIAIG--YPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGE 431
+L V Q+ +F G + +NI G Y + RV + + + NLP G T IGE
Sbjct: 542 TLAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGL---QKDLSNLPYGDLTEIGE 598
Query: 432 RGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-QAALDRASVGRTTLTV 490
RG +LSGGQ+QRI++AR++ + + LLD+ SA+D H K V + + + G+T + V
Sbjct: 599 RGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLV 658
Query: 491 SHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTS--GKETKEPEEIGTVLE 548
+H+L + +C +I ++ G I E+GTH ELM+ +G Y KL+ + G + K+PE +
Sbjct: 659 THQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDPEHLYNAAM 718
Query: 549 EQETKQNGELQPAVRPEPDVKRRSVRKLHRRQSAKGA 585
+ K++ PA R E V K ++S G+
Sbjct: 719 VEAFKES----PAEREEDAVLAPGNEKDEGKESETGS 751
Score = 78.6 bits (185), Expect = 1e-13
Identities = 58/221 (26%), Positives = 99/221 (44%), Gaps = 18/221 (8%)
Query: 923 ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLR 982
+L I V GK + + G+ G GKS++L + G + ++G
Sbjct: 495 VLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGT------------ 542
Query: 983 KQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXX 1042
L V Q+ +F + ENI +G+ K + +LP G T
Sbjct: 543 --LAYVSQQAWIFHGNVRENILFGE---KYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIG 597
Query: 1043 XXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAV-TEALDHAAKGRTCIT 1101
+QR+ +ARA+ +L LLD+ SA+DA+ + V E + +G+T +
Sbjct: 598 ERGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVL 657
Query: 1102 IAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQL 1142
+ H+L ++ D + +L+ G+I EKG H EL+ +G Y +L
Sbjct: 658 VTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKL 698
>AF395908-1|AAL79528.1| 1009|Homo sapiens ATP-binding cassette
protein C12 isoform A protein.
Length = 1009
Score = 126 bits (305), Expect = 3e-28
Identities = 86/277 (31%), Positives = 143/277 (51%), Gaps = 25/277 (9%)
Query: 314 ILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRS 373
+L S ++ G+ + + G+ G GKS++L L +G V ++G
Sbjct: 495 VLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNG------------- 541
Query: 374 SLGVVGQEPVLFRGTIYDNIAIG--YPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGE 431
+L V Q+ +F G + +NI G Y + RV + + + NLP G T IGE
Sbjct: 542 TLAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGL---QKDLSNLPYGDLTEIGE 598
Query: 432 RGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-QAALDRASVGRTTLTV 490
RG +LSGGQ+QRI++AR++ + + LLD+ SA+D H K V + + + G+T + V
Sbjct: 599 RGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLV 658
Query: 491 SHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTS--GKETKEPEEIGTVLE 548
+H+L + +C +I ++ G I E+GTH ELM+ +G Y KL+ + G + K+PE +
Sbjct: 659 THQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDPEHLYNAAM 718
Query: 549 EQETKQNGELQPAVRPEPDVKRRSVRKLHRRQSAKGA 585
+ K++ PA R E V K ++S G+
Sbjct: 719 VEAFKES----PAEREEDAVLAPGNEKDEGKESETGS 751
Score = 78.6 bits (185), Expect = 1e-13
Identities = 58/221 (26%), Positives = 99/221 (44%), Gaps = 18/221 (8%)
Query: 923 ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLR 982
+L I V GK + + G+ G GKS++L + G + ++G
Sbjct: 495 VLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGT------------ 542
Query: 983 KQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXX 1042
L V Q+ +F + ENI +G+ K + +LP G T
Sbjct: 543 --LAYVSQQAWIFHGNVRENILFGE---KYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIG 597
Query: 1043 XXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAV-TEALDHAAKGRTCIT 1101
+QR+ +ARA+ +L LLD+ SA+DA+ + V E + +G+T +
Sbjct: 598 ERGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVL 657
Query: 1102 IAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQL 1142
+ H+L ++ D + +L+ G+I EKG H EL+ +G Y +L
Sbjct: 658 VTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKL 698
>AY196326-1|AAO40749.1| 930|Homo sapiens truncated ABCC12 protein
protein.
Length = 930
Score = 124 bits (300), Expect = 1e-27
Identities = 77/235 (32%), Positives = 128/235 (54%), Gaps = 21/235 (8%)
Query: 314 ILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRS 373
+L S ++ G+ + + G+ G GKS++L L +G V ++G
Sbjct: 437 VLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNG------------- 483
Query: 374 SLGVVGQEPVLFRGTIYDNIAIG--YPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGE 431
+L V Q+ +F G + +NI G Y + RV + + + NLP G T IGE
Sbjct: 484 TLAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGL---QKDLSNLPYGDLTEIGE 540
Query: 432 RGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-QAALDRASVGRTTLTV 490
RG +LSGGQ+QRI++AR++ + + LLD+ SA+D H K V + + + G+T + V
Sbjct: 541 RGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLV 600
Query: 491 SHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTS--GKETKEPEEI 543
+H+L + +C +I ++ G I E+GTH ELM+ +G Y KL+ + G + K+PE +
Sbjct: 601 THQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDPEHL 655
Score = 78.6 bits (185), Expect = 1e-13
Identities = 58/221 (26%), Positives = 99/221 (44%), Gaps = 18/221 (8%)
Query: 923 ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLR 982
+L I V GK + + G+ G GKS++L + G + ++G
Sbjct: 437 VLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGT------------ 484
Query: 983 KQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXX 1042
L V Q+ +F + ENI +G+ K + +LP G T
Sbjct: 485 --LAYVSQQAWIFHGNVRENILFGE---KYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIG 539
Query: 1043 XXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAV-TEALDHAAKGRTCIT 1101
+QR+ +ARA+ +L LLD+ SA+DA+ + V E + +G+T +
Sbjct: 540 ERGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVL 599
Query: 1102 IAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQL 1142
+ H+L ++ D + +L+ G+I EKG H EL+ +G Y +L
Sbjct: 600 VTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKL 640
>M55131-1|AAC13657.1| 1480|Homo sapiens cystic fibrosis transmembrane
conductance regulator protein.
Length = 1480
Score = 122 bits (294), Expect = 7e-27
Identities = 63/244 (25%), Positives = 132/244 (54%), Gaps = 3/244 (1%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G+++++D+ Y + IL+ S I PG+ V L+G +G GKST+L RL + +G
Sbjct: 1208 GQMTVKDLTAKYTEGGNA-ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN-TEG 1265
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+++DG + ++ + R + GV+ Q+ +F GT N+ Y + + +++++VA+
Sbjct: 1266 EIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGL 1324
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
I+ P + V+ + G LS G KQ + +ARS+L + +LLLDE ++ LDP + + +
Sbjct: 1325 RSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQII 1384
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSG 534
+ L +A T + HR+ ++ C + + +++ + + + +L+ + + + ++
Sbjct: 1385 RRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPS 1444
Query: 535 KETK 538
K
Sbjct: 1445 DRVK 1448
Score = 94.3 bits (224), Expect = 2e-18
Identities = 64/257 (24%), Positives = 119/257 (46%), Gaps = 8/257 (3%)
Query: 887 RIRTVDGLNDKQD--WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSG 944
++ ++ + K+D W + G ++ D+ Y T IL+ I + G+ V L+G +G
Sbjct: 1189 KVMIIENSHVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRVGLLGRTG 1247
Query: 945 CGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIA 1004
GKST+L R + T G I++DGV S+TL + RK GV+ Q+ +F T +N+
Sbjct: 1248 SGKSTLLSAFLRLLN-TEGEIQIDGVS-WDSITLQQWRKAFGVIPQKVFIFSGTFRKNL- 1304
Query: 1005 YGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIR 1064
D + + E + I P + KQ +C+AR+++
Sbjct: 1305 --DPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLS 1362
Query: 1065 SPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIV 1124
++LLLDE ++ LD + + + L A T I HR+ + + V+++ K+
Sbjct: 1363 KAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVR 1422
Query: 1125 EKGNHAELIGLKGHYWQ 1141
+ + +L+ + + Q
Sbjct: 1423 QYDSIQKLLNERSLFRQ 1439
Score = 87.8 bits (208), Expect = 2e-16
Identities = 64/237 (27%), Positives = 115/237 (48%), Gaps = 22/237 (9%)
Query: 300 EDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLD 359
+ + FS S +LK + I+ G+ +A+ GS+G GK+++L ++ +P++G +K
Sbjct: 426 DSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHS 485
Query: 360 GRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYR---VAEMAYAHE 416
GR W+ GTI +NI G S D YR V + E
Sbjct: 486 GRISFCSQFSWIMP-------------GTIKENIIFG----VSYDEYRYRSVIKACQLEE 528
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-Q 475
I V+GE G +LSGGQ+ RI++AR++ ++ + LLD LD +EK++ +
Sbjct: 529 DISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFE 588
Query: 476 AALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAK-GFYHKLV 531
+ + + +T + V+ ++ + +I+ + +G+ GT EL + F KL+
Sbjct: 589 SCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 51.2 bits (117), Expect = 2e-05
Identities = 50/217 (23%), Positives = 90/217 (41%), Gaps = 22/217 (10%)
Query: 923 ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLR 982
+LK I+ +E G+ +A+ GS+G GK+++L +I +P+ G I+ G
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSG------------- 486
Query: 983 KQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXX--XHNFIVSLPKGYETN 1040
++ Q + T+ ENI +G + DE I +
Sbjct: 487 -RISFCSQFSWIMPGTIKENIIFG-----VSYDEYRYRSVIKACQLEEDISKFAEKDNIV 540
Query: 1041 XXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEA-LDHAAKGRTC 1099
+ R+ +ARA+ + L LLD LD +E+ + E+ + +T
Sbjct: 541 LGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTR 600
Query: 1100 ITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLK 1136
I + ++ +K AD I +L +G G +EL L+
Sbjct: 601 ILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQ 637
Score = 35.1 bits (77), Expect = 1.5
Identities = 33/116 (28%), Positives = 52/116 (44%), Gaps = 6/116 (5%)
Query: 682 GAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGS 741
G + R S D A + L I +Q + +G I ++ V+T +P++V
Sbjct: 970 GGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGAIAVVAVLQPYIFVAT--VPVIVAF 1026
Query: 742 IWLEGIMSQKSQQDEREAMESATAIATEAVVSIK---TVQSLGIESLFITRFQDAL 794
I L Q SQQ ++ E + I T V S+K T+++ G + F T F AL
Sbjct: 1027 IMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKAL 1082
>M28668-1|AAA35680.1| 1480|Homo sapiens protein ( Human cystic
fibrosis mRNA, encoding a presumed transmembrane
conductance regulator (CFTR). ).
Length = 1480
Score = 122 bits (294), Expect = 7e-27
Identities = 63/244 (25%), Positives = 132/244 (54%), Gaps = 3/244 (1%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G+++++D+ Y + IL+ S I PG+ V L+G +G GKST+L RL + +G
Sbjct: 1208 GQMTVKDLTAKYTEGGNA-ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN-TEG 1265
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+++DG + ++ + R + GV+ Q+ +F GT N+ Y + + +++++VA+
Sbjct: 1266 EIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGL 1324
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
I+ P + V+ + G LS G KQ + +ARS+L + +LLLDE ++ LDP + + +
Sbjct: 1325 RSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQII 1384
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSG 534
+ L +A T + HR+ ++ C + + +++ + + + +L+ + + + ++
Sbjct: 1385 RRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPS 1444
Query: 535 KETK 538
K
Sbjct: 1445 DRVK 1448
Score = 94.3 bits (224), Expect = 2e-18
Identities = 64/257 (24%), Positives = 119/257 (46%), Gaps = 8/257 (3%)
Query: 887 RIRTVDGLNDKQD--WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSG 944
++ ++ + K+D W + G ++ D+ Y T IL+ I + G+ V L+G +G
Sbjct: 1189 KVMIIENSHVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRVGLLGRTG 1247
Query: 945 CGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIA 1004
GKST+L R + T G I++DGV S+TL + RK GV+ Q+ +F T +N+
Sbjct: 1248 SGKSTLLSAFLRLLN-TEGEIQIDGVS-WDSITLQQWRKAFGVIPQKVFIFSGTFRKNL- 1304
Query: 1005 YGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIR 1064
D + + E + I P + KQ +C+AR+++
Sbjct: 1305 --DPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLS 1362
Query: 1065 SPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIV 1124
++LLLDE ++ LD + + + L A T I HR+ + + V+++ K+
Sbjct: 1363 KAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVR 1422
Query: 1125 EKGNHAELIGLKGHYWQ 1141
+ + +L+ + + Q
Sbjct: 1423 QYDSIQKLLNERSLFRQ 1439
Score = 88.6 bits (210), Expect = 1e-16
Identities = 64/237 (27%), Positives = 116/237 (48%), Gaps = 22/237 (9%)
Query: 300 EDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLD 359
+ + FS S +LK + I+ G+ +A+ GS+G GK+++L ++ +P++G +K
Sbjct: 426 DSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHS 485
Query: 360 GRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYR---VAEMAYAHE 416
GR W+ GTI +NI G S D YR V + E
Sbjct: 486 GRISFCSQFSWIMP-------------GTIKENIIFG----VSYDEYRYRSVIKACQLEE 528
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-Q 475
I V+GE G +LSGGQ+ RI++AR++ ++ + LLD LD +EK++ +
Sbjct: 529 DISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFE 588
Query: 476 AALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAK-GFYHKLV 531
+ + + +T + V+ ++ + +I+ +++G+ GT EL + F KL+
Sbjct: 589 SCVCKLMANKTRILVTSKMEHLKKADKILILNEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 52.0 bits (119), Expect = 1e-05
Identities = 50/217 (23%), Positives = 91/217 (41%), Gaps = 22/217 (10%)
Query: 923 ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLR 982
+LK I+ +E G+ +A+ GS+G GK+++L +I +P+ G I+ G
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSG------------- 486
Query: 983 KQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXX--XHNFIVSLPKGYETN 1040
++ Q + T+ ENI +G + DE I +
Sbjct: 487 -RISFCSQFSWIMPGTIKENIIFG-----VSYDEYRYRSVIKACQLEEDISKFAEKDNIV 540
Query: 1041 XXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEA-LDHAAKGRTC 1099
+ R+ +ARA+ + L LLD LD +E+ + E+ + +T
Sbjct: 541 LGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTR 600
Query: 1100 ITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLK 1136
I + ++ +K AD I +L++G G +EL L+
Sbjct: 601 ILVTSKMEHLKKADKILILNEGSSYFYGTFSELQNLQ 637
Score = 35.1 bits (77), Expect = 1.5
Identities = 33/116 (28%), Positives = 52/116 (44%), Gaps = 6/116 (5%)
Query: 682 GAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGS 741
G + R S D A + L I +Q + +G I ++ V+T +P++V
Sbjct: 970 GGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGAIAVVAVLQPYIFVAT--VPVIVAF 1026
Query: 742 IWLEGIMSQKSQQDEREAMESATAIATEAVVSIK---TVQSLGIESLFITRFQDAL 794
I L Q SQQ ++ E + I T V S+K T+++ G + F T F AL
Sbjct: 1027 IMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKAL 1082
>DQ388145-1|ABD72217.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 122 bits (294), Expect = 7e-27
Identities = 63/244 (25%), Positives = 132/244 (54%), Gaps = 3/244 (1%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G+++++D+ Y + IL+ S I PG+ V L+G +G GKST+L RL + +G
Sbjct: 1208 GQMTVKDLTAKYTEGGNA-ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN-TEG 1265
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+++DG + ++ + R + GV+ Q+ +F GT N+ Y + + +++++VA+
Sbjct: 1266 EIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGL 1324
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
I+ P + V+ + G LS G KQ + +ARS+L + +LLLDE ++ LDP + + +
Sbjct: 1325 RSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQII 1384
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSG 534
+ L +A T + HR+ ++ C + + +++ + + + +L+ + + + ++
Sbjct: 1385 RRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPS 1444
Query: 535 KETK 538
K
Sbjct: 1445 DRVK 1448
Score = 94.3 bits (224), Expect = 2e-18
Identities = 64/257 (24%), Positives = 119/257 (46%), Gaps = 8/257 (3%)
Query: 887 RIRTVDGLNDKQD--WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSG 944
++ ++ + K+D W + G ++ D+ Y T IL+ I + G+ V L+G +G
Sbjct: 1189 KVMIIENSHVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRVGLLGRTG 1247
Query: 945 CGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIA 1004
GKST+L R + T G I++DGV S+TL + RK GV+ Q+ +F T +N+
Sbjct: 1248 SGKSTLLSAFLRLLN-TEGEIQIDGVS-WDSITLQQWRKAFGVIPQKVFIFSGTFRKNL- 1304
Query: 1005 YGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIR 1064
D + + E + I P + KQ +C+AR+++
Sbjct: 1305 --DPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLS 1362
Query: 1065 SPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIV 1124
++LLLDE ++ LD + + + L A T I HR+ + + V+++ K+
Sbjct: 1363 KAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVR 1422
Query: 1125 EKGNHAELIGLKGHYWQ 1141
+ + +L+ + + Q
Sbjct: 1423 QYDSIQKLLNERSLFRQ 1439
Score = 87.4 bits (207), Expect = 3e-16
Identities = 64/237 (27%), Positives = 115/237 (48%), Gaps = 22/237 (9%)
Query: 300 EDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLD 359
+ + FS S +LK + I+ G+ +A+ GS+G GK+++L ++ +P++G +K
Sbjct: 426 DSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHS 485
Query: 360 GRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYR---VAEMAYAHE 416
GR W+ GTI +NI G S D YR V + E
Sbjct: 486 GRISFCSQFSWIMP-------------GTIKENIIFG----VSYDEYRYRSVIKACQLEE 528
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-Q 475
I V+GE G +LSGGQ+ RI++AR++ ++ + LLD LD +EK++ +
Sbjct: 529 DISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFE 588
Query: 476 AALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAK-GFYHKLV 531
+ + + +T + V+ ++ + +I+ + +G+ GT EL + F KL+
Sbjct: 589 SCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 50.8 bits (116), Expect = 3e-05
Identities = 50/217 (23%), Positives = 90/217 (41%), Gaps = 22/217 (10%)
Query: 923 ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLR 982
+LK I+ +E G+ +A+ GS+G GK+++L +I +P+ G I+ G
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG------------- 486
Query: 983 KQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXX--XHNFIVSLPKGYETN 1040
++ Q + T+ ENI +G + DE I +
Sbjct: 487 -RISFCSQFSWIMPGTIKENIIFG-----VSYDEYRYRSVIKACQLEEDISKFAEKDNIV 540
Query: 1041 XXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEA-LDHAAKGRTC 1099
+ R+ +ARA+ + L LLD LD +E+ + E+ + +T
Sbjct: 541 LGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTR 600
Query: 1100 ITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLK 1136
I + ++ +K AD I +L +G G +EL L+
Sbjct: 601 ILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQ 637
Score = 35.1 bits (77), Expect = 1.5
Identities = 33/116 (28%), Positives = 52/116 (44%), Gaps = 6/116 (5%)
Query: 682 GAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGS 741
G + R S D A + L I +Q + +G I ++ V+T +P++V
Sbjct: 970 GGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGAIAVVAVLQPYIFVAT--VPVIVAF 1026
Query: 742 IWLEGIMSQKSQQDEREAMESATAIATEAVVSIK---TVQSLGIESLFITRFQDAL 794
I L Q SQQ ++ E + I T V S+K T+++ G + F T F AL
Sbjct: 1027 IMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKAL 1082
>DQ388143-1|ABD72213.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 122 bits (294), Expect = 7e-27
Identities = 63/244 (25%), Positives = 132/244 (54%), Gaps = 3/244 (1%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G+++++D+ Y + IL+ S I PG+ V L+G +G GKST+L RL + +G
Sbjct: 1208 GQMTVKDLTAKYTEGGNA-ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN-TEG 1265
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+++DG + ++ + R + GV+ Q+ +F GT N+ Y + + +++++VA+
Sbjct: 1266 EIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGL 1324
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
I+ P + V+ + G LS G KQ + +ARS+L + +LLLDE ++ LDP + + +
Sbjct: 1325 RSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQII 1384
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSG 534
+ L +A T + HR+ ++ C + + +++ + + + +L+ + + + ++
Sbjct: 1385 RRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPS 1444
Query: 535 KETK 538
K
Sbjct: 1445 DRVK 1448
Score = 94.3 bits (224), Expect = 2e-18
Identities = 64/257 (24%), Positives = 119/257 (46%), Gaps = 8/257 (3%)
Query: 887 RIRTVDGLNDKQD--WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSG 944
++ ++ + K+D W + G ++ D+ Y T IL+ I + G+ V L+G +G
Sbjct: 1189 KVMIIENSHVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRVGLLGRTG 1247
Query: 945 CGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIA 1004
GKST+L R + T G I++DGV S+TL + RK GV+ Q+ +F T +N+
Sbjct: 1248 SGKSTLLSAFLRLLN-TEGEIQIDGVS-WDSITLQQWRKAFGVIPQKVFIFSGTFRKNL- 1304
Query: 1005 YGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIR 1064
D + + E + I P + KQ +C+AR+++
Sbjct: 1305 --DPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLS 1362
Query: 1065 SPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIV 1124
++LLLDE ++ LD + + + L A T I HR+ + + V+++ K+
Sbjct: 1363 KAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVR 1422
Query: 1125 EKGNHAELIGLKGHYWQ 1141
+ + +L+ + + Q
Sbjct: 1423 QYDSIQKLLNERSLFRQ 1439
Score = 87.4 bits (207), Expect = 3e-16
Identities = 64/237 (27%), Positives = 115/237 (48%), Gaps = 22/237 (9%)
Query: 300 EDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLD 359
+ + FS S +LK + I+ G+ +A+ GS+G GK+++L ++ +P++G +K
Sbjct: 426 DSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHS 485
Query: 360 GRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYR---VAEMAYAHE 416
GR W+ GTI +NI G S D YR V + E
Sbjct: 486 GRISFCSQFSWIMP-------------GTIKENIIFG----VSYDEYRYRSVIKACQLEE 528
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-Q 475
I V+GE G +LSGGQ+ RI++AR++ ++ + LLD LD +EK++ +
Sbjct: 529 DISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFE 588
Query: 476 AALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAK-GFYHKLV 531
+ + + +T + V+ ++ + +I+ + +G+ GT EL + F KL+
Sbjct: 589 SCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 50.8 bits (116), Expect = 3e-05
Identities = 50/217 (23%), Positives = 90/217 (41%), Gaps = 22/217 (10%)
Query: 923 ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLR 982
+LK I+ +E G+ +A+ GS+G GK+++L +I +P+ G I+ G
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG------------- 486
Query: 983 KQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXX--XHNFIVSLPKGYETN 1040
++ Q + T+ ENI +G + DE I +
Sbjct: 487 -RISFCSQFSWIMPGTIKENIIFG-----VSYDEYRYRSVIKACQLEEDISKFAEKDNIV 540
Query: 1041 XXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEA-LDHAAKGRTC 1099
+ R+ +ARA+ + L LLD LD +E+ + E+ + +T
Sbjct: 541 LGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTR 600
Query: 1100 ITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLK 1136
I + ++ +K AD I +L +G G +EL L+
Sbjct: 601 ILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQ 637
Score = 35.1 bits (77), Expect = 1.5
Identities = 33/116 (28%), Positives = 52/116 (44%), Gaps = 6/116 (5%)
Query: 682 GAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGS 741
G + R S D A + L I +Q + +G I ++ V+T +P++V
Sbjct: 970 GGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGAIAVVAVLQPYIFVAT--VPVIVAF 1026
Query: 742 IWLEGIMSQKSQQDEREAMESATAIATEAVVSIK---TVQSLGIESLFITRFQDAL 794
I L Q SQQ ++ E + I T V S+K T+++ G + F T F AL
Sbjct: 1027 IMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKAL 1082
>DQ388142-1|ABD72211.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 122 bits (294), Expect = 7e-27
Identities = 63/244 (25%), Positives = 132/244 (54%), Gaps = 3/244 (1%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G+++++D+ Y + IL+ S I PG+ V L+G +G GKST+L RL + +G
Sbjct: 1208 GQMTVKDLTAKYTEGGNA-ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN-TEG 1265
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+++DG + ++ + R + GV+ Q+ +F GT N+ Y + + +++++VA+
Sbjct: 1266 EIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGL 1324
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
I+ P + V+ + G LS G KQ + +ARS+L + +LLLDE ++ LDP + + +
Sbjct: 1325 RSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQII 1384
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSG 534
+ L +A T + HR+ ++ C + + +++ + + + +L+ + + + ++
Sbjct: 1385 RRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPS 1444
Query: 535 KETK 538
K
Sbjct: 1445 DRVK 1448
Score = 94.3 bits (224), Expect = 2e-18
Identities = 64/257 (24%), Positives = 119/257 (46%), Gaps = 8/257 (3%)
Query: 887 RIRTVDGLNDKQD--WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSG 944
++ ++ + K+D W + G ++ D+ Y T IL+ I + G+ V L+G +G
Sbjct: 1189 KVMIIENSHVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRVGLLGRTG 1247
Query: 945 CGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIA 1004
GKST+L R + T G I++DGV S+TL + RK GV+ Q+ +F T +N+
Sbjct: 1248 SGKSTLLSAFLRLLN-TEGEIQIDGVS-WDSITLQQWRKAFGVIPQKVFIFSGTFRKNL- 1304
Query: 1005 YGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIR 1064
D + + E + I P + KQ +C+AR+++
Sbjct: 1305 --DPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLS 1362
Query: 1065 SPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIV 1124
++LLLDE ++ LD + + + L A T I HR+ + + V+++ K+
Sbjct: 1363 KAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVR 1422
Query: 1125 EKGNHAELIGLKGHYWQ 1141
+ + +L+ + + Q
Sbjct: 1423 QYDSIQKLLNERSLFRQ 1439
Score = 87.4 bits (207), Expect = 3e-16
Identities = 64/237 (27%), Positives = 115/237 (48%), Gaps = 22/237 (9%)
Query: 300 EDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLD 359
+ + FS S +LK + I+ G+ +A+ GS+G GK+++L ++ +P++G +K
Sbjct: 426 DSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHS 485
Query: 360 GRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYR---VAEMAYAHE 416
GR W+ GTI +NI G S D YR V + E
Sbjct: 486 GRISFCSQFSWIMP-------------GTIKENIIFG----VSYDEYRYRSVIKACQLEE 528
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-Q 475
I V+GE G +LSGGQ+ RI++AR++ ++ + LLD LD +EK++ +
Sbjct: 529 DISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFE 588
Query: 476 AALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAK-GFYHKLV 531
+ + + +T + V+ ++ + +I+ + +G+ GT EL + F KL+
Sbjct: 589 SCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 50.8 bits (116), Expect = 3e-05
Identities = 50/217 (23%), Positives = 90/217 (41%), Gaps = 22/217 (10%)
Query: 923 ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLR 982
+LK I+ +E G+ +A+ GS+G GK+++L +I +P+ G I+ G
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG------------- 486
Query: 983 KQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXX--XHNFIVSLPKGYETN 1040
++ Q + T+ ENI +G + DE I +
Sbjct: 487 -RISFCSQFSWIMPGTIKENIIFG-----VSYDEYRYRSVIKACQLEEDISKFAEKDNIV 540
Query: 1041 XXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEA-LDHAAKGRTC 1099
+ R+ +ARA+ + L LLD LD +E+ + E+ + +T
Sbjct: 541 LGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTR 600
Query: 1100 ITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLK 1136
I + ++ +K AD I +L +G G +EL L+
Sbjct: 601 ILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQ 637
Score = 35.1 bits (77), Expect = 1.5
Identities = 33/116 (28%), Positives = 52/116 (44%), Gaps = 6/116 (5%)
Query: 682 GAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGS 741
G + R S D A + L I +Q + +G I ++ V+T +P++V
Sbjct: 970 GGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGAIAVVAVLQPYIFVAT--VPVIVAF 1026
Query: 742 IWLEGIMSQKSQQDEREAMESATAIATEAVVSIK---TVQSLGIESLFITRFQDAL 794
I L Q SQQ ++ E + I T V S+K T+++ G + F T F AL
Sbjct: 1027 IMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKAL 1082
>DQ388141-1|ABD72209.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 122 bits (294), Expect = 7e-27
Identities = 63/244 (25%), Positives = 132/244 (54%), Gaps = 3/244 (1%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G+++++D+ Y + IL+ S I PG+ V L+G +G GKST+L RL + +G
Sbjct: 1208 GQMTVKDLTAKYTEGGNA-ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN-TEG 1265
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+++DG + ++ + R + GV+ Q+ +F GT N+ Y + + +++++VA+
Sbjct: 1266 EIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGL 1324
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
I+ P + V+ + G LS G KQ + +ARS+L + +LLLDE ++ LDP + + +
Sbjct: 1325 RSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQII 1384
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSG 534
+ L +A T + HR+ ++ C + + +++ + + + +L+ + + + ++
Sbjct: 1385 RRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPS 1444
Query: 535 KETK 538
K
Sbjct: 1445 DRVK 1448
Score = 94.3 bits (224), Expect = 2e-18
Identities = 64/257 (24%), Positives = 119/257 (46%), Gaps = 8/257 (3%)
Query: 887 RIRTVDGLNDKQD--WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSG 944
++ ++ + K+D W + G ++ D+ Y T IL+ I + G+ V L+G +G
Sbjct: 1189 KVMIIENSHVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRVGLLGRTG 1247
Query: 945 CGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIA 1004
GKST+L R + T G I++DGV S+TL + RK GV+ Q+ +F T +N+
Sbjct: 1248 SGKSTLLSAFLRLLN-TEGEIQIDGVS-WDSITLQQWRKAFGVIPQKVFIFSGTFRKNL- 1304
Query: 1005 YGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIR 1064
D + + E + I P + KQ +C+AR+++
Sbjct: 1305 --DPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLS 1362
Query: 1065 SPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIV 1124
++LLLDE ++ LD + + + L A T I HR+ + + V+++ K+
Sbjct: 1363 KAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVR 1422
Query: 1125 EKGNHAELIGLKGHYWQ 1141
+ + +L+ + + Q
Sbjct: 1423 QYDSIQKLLNERSLFRQ 1439
Score = 87.4 bits (207), Expect = 3e-16
Identities = 64/237 (27%), Positives = 115/237 (48%), Gaps = 22/237 (9%)
Query: 300 EDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLD 359
+ + FS S +LK + I+ G+ +A+ GS+G GK+++L ++ +P++G +K
Sbjct: 426 DSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHS 485
Query: 360 GRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYR---VAEMAYAHE 416
GR W+ GTI +NI G S D YR V + E
Sbjct: 486 GRISFCSQFSWIMP-------------GTIKENIIFG----VSYDEYRYRSVIKACQLEE 528
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-Q 475
I V+GE G +LSGGQ+ RI++AR++ ++ + LLD LD +EK++ +
Sbjct: 529 DISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFE 588
Query: 476 AALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAK-GFYHKLV 531
+ + + +T + V+ ++ + +I+ + +G+ GT EL + F KL+
Sbjct: 589 SCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 50.8 bits (116), Expect = 3e-05
Identities = 50/217 (23%), Positives = 90/217 (41%), Gaps = 22/217 (10%)
Query: 923 ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLR 982
+LK I+ +E G+ +A+ GS+G GK+++L +I +P+ G I+ G
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG------------- 486
Query: 983 KQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXX--XHNFIVSLPKGYETN 1040
++ Q + T+ ENI +G + DE I +
Sbjct: 487 -RISFCSQFSWIMPGTIKENIIFG-----VSYDEYRYRSVIKACQLEEDISKFAEKDNIV 540
Query: 1041 XXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEA-LDHAAKGRTC 1099
+ R+ +ARA+ + L LLD LD +E+ + E+ + +T
Sbjct: 541 LGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTR 600
Query: 1100 ITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLK 1136
I + ++ +K AD I +L +G G +EL L+
Sbjct: 601 ILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQ 637
Score = 35.1 bits (77), Expect = 1.5
Identities = 33/116 (28%), Positives = 52/116 (44%), Gaps = 6/116 (5%)
Query: 682 GAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGS 741
G + R S D A + L I +Q + +G I ++ V+T +P++V
Sbjct: 970 GGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGAIAVVAVLQPYIFVAT--VPVIVAF 1026
Query: 742 IWLEGIMSQKSQQDEREAMESATAIATEAVVSIK---TVQSLGIESLFITRFQDAL 794
I L Q SQQ ++ E + I T V S+K T+++ G + F T F AL
Sbjct: 1027 IMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKAL 1082
>DQ388140-1|ABD72207.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 122 bits (294), Expect = 7e-27
Identities = 63/244 (25%), Positives = 132/244 (54%), Gaps = 3/244 (1%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G+++++D+ Y + IL+ S I PG+ V L+G +G GKST+L RL + +G
Sbjct: 1208 GQMTVKDLTAKYTEGGNA-ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN-TEG 1265
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+++DG + ++ + R + GV+ Q+ +F GT N+ Y + + +++++VA+
Sbjct: 1266 EIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGL 1324
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
I+ P + V+ + G LS G KQ + +ARS+L + +LLLDE ++ LDP + + +
Sbjct: 1325 RSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQII 1384
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSG 534
+ L +A T + HR+ ++ C + + +++ + + + +L+ + + + ++
Sbjct: 1385 RRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPS 1444
Query: 535 KETK 538
K
Sbjct: 1445 DRVK 1448
Score = 94.3 bits (224), Expect = 2e-18
Identities = 64/257 (24%), Positives = 119/257 (46%), Gaps = 8/257 (3%)
Query: 887 RIRTVDGLNDKQD--WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSG 944
++ ++ + K+D W + G ++ D+ Y T IL+ I + G+ V L+G +G
Sbjct: 1189 KVMIIENSHVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRVGLLGRTG 1247
Query: 945 CGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIA 1004
GKST+L R + T G I++DGV S+TL + RK GV+ Q+ +F T +N+
Sbjct: 1248 SGKSTLLSAFLRLLN-TEGEIQIDGVS-WDSITLQQWRKAFGVIPQKVFIFSGTFRKNL- 1304
Query: 1005 YGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIR 1064
D + + E + I P + KQ +C+AR+++
Sbjct: 1305 --DPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLS 1362
Query: 1065 SPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIV 1124
++LLLDE ++ LD + + + L A T I HR+ + + V+++ K+
Sbjct: 1363 KAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVR 1422
Query: 1125 EKGNHAELIGLKGHYWQ 1141
+ + +L+ + + Q
Sbjct: 1423 QYDSIQKLLNERSLFRQ 1439
Score = 87.8 bits (208), Expect = 2e-16
Identities = 64/237 (27%), Positives = 115/237 (48%), Gaps = 22/237 (9%)
Query: 300 EDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLD 359
+ + FS S +LK + I+ G+ +A+ GS+G GK+++L ++ +P++G +K
Sbjct: 426 DSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHS 485
Query: 360 GRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYR---VAEMAYAHE 416
GR W+ GTI +NI G S D YR V + E
Sbjct: 486 GRISFCSQFSWIMP-------------GTIKENIIFG----VSYDEYRYRSVIKACQLEE 528
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-Q 475
I V+GE G +LSGGQ+ RI++AR++ ++ + LLD LD +EK++ +
Sbjct: 529 DISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFE 588
Query: 476 AALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAK-GFYHKLV 531
+ + + +T + V+ ++ + +I+ + +G+ GT EL + F KL+
Sbjct: 589 SCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 51.2 bits (117), Expect = 2e-05
Identities = 50/217 (23%), Positives = 90/217 (41%), Gaps = 22/217 (10%)
Query: 923 ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLR 982
+LK I+ +E G+ +A+ GS+G GK+++L +I +P+ G I+ G
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSG------------- 486
Query: 983 KQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXX--XHNFIVSLPKGYETN 1040
++ Q + T+ ENI +G + DE I +
Sbjct: 487 -RISFCSQFSWIMPGTIKENIIFG-----VSYDEYRYRSVIKACQLEEDISKFAEKDNIV 540
Query: 1041 XXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEA-LDHAAKGRTC 1099
+ R+ +ARA+ + L LLD LD +E+ + E+ + +T
Sbjct: 541 LGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTR 600
Query: 1100 ITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLK 1136
I + ++ +K AD I +L +G G +EL L+
Sbjct: 601 ILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQ 637
Score = 35.1 bits (77), Expect = 1.5
Identities = 33/116 (28%), Positives = 52/116 (44%), Gaps = 6/116 (5%)
Query: 682 GAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGS 741
G + R S D A + L I +Q + +G I ++ V+T +P++V
Sbjct: 970 GGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGAIAVVAVLQPYIFVAT--VPVIVAF 1026
Query: 742 IWLEGIMSQKSQQDEREAMESATAIATEAVVSIK---TVQSLGIESLFITRFQDAL 794
I L Q SQQ ++ E + I T V S+K T+++ G + F T F AL
Sbjct: 1027 IMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKAL 1082
>DQ388139-1|ABD72205.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 122 bits (294), Expect = 7e-27
Identities = 63/244 (25%), Positives = 132/244 (54%), Gaps = 3/244 (1%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G+++++D+ Y + IL+ S I PG+ V L+G +G GKST+L RL + +G
Sbjct: 1208 GQMTVKDLTAKYTEGGNA-ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN-TEG 1265
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+++DG + ++ + R + GV+ Q+ +F GT N+ Y + + +++++VA+
Sbjct: 1266 EIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGL 1324
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
I+ P + V+ + G LS G KQ + +ARS+L + +LLLDE ++ LDP + + +
Sbjct: 1325 RSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQII 1384
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSG 534
+ L +A T + HR+ ++ C + + +++ + + + +L+ + + + ++
Sbjct: 1385 RRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPS 1444
Query: 535 KETK 538
K
Sbjct: 1445 DRVK 1448
Score = 94.3 bits (224), Expect = 2e-18
Identities = 64/257 (24%), Positives = 119/257 (46%), Gaps = 8/257 (3%)
Query: 887 RIRTVDGLNDKQD--WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSG 944
++ ++ + K+D W + G ++ D+ Y T IL+ I + G+ V L+G +G
Sbjct: 1189 KVMIIENSHVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRVGLLGRTG 1247
Query: 945 CGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIA 1004
GKST+L R + T G I++DGV S+TL + RK GV+ Q+ +F T +N+
Sbjct: 1248 SGKSTLLSAFLRLLN-TEGEIQIDGVS-WDSITLQQWRKAFGVIPQKVFIFSGTFRKNL- 1304
Query: 1005 YGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIR 1064
D + + E + I P + KQ +C+AR+++
Sbjct: 1305 --DPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLS 1362
Query: 1065 SPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIV 1124
++LLLDE ++ LD + + + L A T I HR+ + + V+++ K+
Sbjct: 1363 KAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVR 1422
Query: 1125 EKGNHAELIGLKGHYWQ 1141
+ + +L+ + + Q
Sbjct: 1423 QYDSIQKLLNERSLFRQ 1439
Score = 87.4 bits (207), Expect = 3e-16
Identities = 64/237 (27%), Positives = 115/237 (48%), Gaps = 22/237 (9%)
Query: 300 EDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLD 359
+ + FS S +LK + I+ G+ +A+ GS+G GK+++L ++ +P++G +K
Sbjct: 426 DSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHS 485
Query: 360 GRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYR---VAEMAYAHE 416
GR W+ GTI +NI G S D YR V + E
Sbjct: 486 GRISFCSQFSWIMP-------------GTIKENIIFG----VSYDEYRYRSVIKACQLEE 528
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-Q 475
I V+GE G +LSGGQ+ RI++AR++ ++ + LLD LD +EK++ +
Sbjct: 529 DISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFE 588
Query: 476 AALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAK-GFYHKLV 531
+ + + +T + V+ ++ + +I+ + +G+ GT EL + F KL+
Sbjct: 589 SCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 50.8 bits (116), Expect = 3e-05
Identities = 50/217 (23%), Positives = 90/217 (41%), Gaps = 22/217 (10%)
Query: 923 ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLR 982
+LK I+ +E G+ +A+ GS+G GK+++L +I +P+ G I+ G
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG------------- 486
Query: 983 KQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXX--XHNFIVSLPKGYETN 1040
++ Q + T+ ENI +G + DE I +
Sbjct: 487 -RISFCSQFSWIMPGTIKENIIFG-----VSYDEYRYRSVIKACQLEEDISKFAEKDNIV 540
Query: 1041 XXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEA-LDHAAKGRTC 1099
+ R+ +ARA+ + L LLD LD +E+ + E+ + +T
Sbjct: 541 LGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTR 600
Query: 1100 ITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLK 1136
I + ++ +K AD I +L +G G +EL L+
Sbjct: 601 ILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQ 637
Score = 35.1 bits (77), Expect = 1.5
Identities = 33/116 (28%), Positives = 52/116 (44%), Gaps = 6/116 (5%)
Query: 682 GAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGS 741
G + R S D A + L I +Q + +G I ++ V+T +P++V
Sbjct: 970 GGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGAIAVVAVLQPYIFVAT--VPVIVAF 1026
Query: 742 IWLEGIMSQKSQQDEREAMESATAIATEAVVSIK---TVQSLGIESLFITRFQDAL 794
I L Q SQQ ++ E + I T V S+K T+++ G + F T F AL
Sbjct: 1027 IMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKAL 1082
>DQ388138-1|ABD72203.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 122 bits (294), Expect = 7e-27
Identities = 63/244 (25%), Positives = 132/244 (54%), Gaps = 3/244 (1%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G+++++D+ Y + IL+ S I PG+ V L+G +G GKST+L RL + +G
Sbjct: 1208 GQMTVKDLTAKYTEGGNA-ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN-TEG 1265
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+++DG + ++ + R + GV+ Q+ +F GT N+ Y + + +++++VA+
Sbjct: 1266 EIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGL 1324
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
I+ P + V+ + G LS G KQ + +ARS+L + +LLLDE ++ LDP + + +
Sbjct: 1325 RSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQII 1384
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSG 534
+ L +A T + HR+ ++ C + + +++ + + + +L+ + + + ++
Sbjct: 1385 RRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPS 1444
Query: 535 KETK 538
K
Sbjct: 1445 DRVK 1448
Score = 94.3 bits (224), Expect = 2e-18
Identities = 64/257 (24%), Positives = 119/257 (46%), Gaps = 8/257 (3%)
Query: 887 RIRTVDGLNDKQD--WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSG 944
++ ++ + K+D W + G ++ D+ Y T IL+ I + G+ V L+G +G
Sbjct: 1189 KVMIIENSHVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRVGLLGRTG 1247
Query: 945 CGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIA 1004
GKST+L R + T G I++DGV S+TL + RK GV+ Q+ +F T +N+
Sbjct: 1248 SGKSTLLSAFLRLLN-TEGEIQIDGVS-WDSITLQQWRKAFGVIPQKVFIFSGTFRKNL- 1304
Query: 1005 YGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIR 1064
D + + E + I P + KQ +C+AR+++
Sbjct: 1305 --DPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLS 1362
Query: 1065 SPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIV 1124
++LLLDE ++ LD + + + L A T I HR+ + + V+++ K+
Sbjct: 1363 KAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVR 1422
Query: 1125 EKGNHAELIGLKGHYWQ 1141
+ + +L+ + + Q
Sbjct: 1423 QYDSIQKLLNERSLFRQ 1439
Score = 87.8 bits (208), Expect = 2e-16
Identities = 64/237 (27%), Positives = 115/237 (48%), Gaps = 22/237 (9%)
Query: 300 EDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLD 359
+ + FS S +LK + I+ G+ +A+ GS+G GK+++L ++ +P++G +K
Sbjct: 426 DSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHS 485
Query: 360 GRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYR---VAEMAYAHE 416
GR W+ GTI +NI G S D YR V + E
Sbjct: 486 GRISFCSQFSWIMP-------------GTIKENIIFG----VSYDEYRYRSVIKACQLEE 528
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-Q 475
I V+GE G +LSGGQ+ RI++AR++ ++ + LLD LD +EK++ +
Sbjct: 529 DISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFE 588
Query: 476 AALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAK-GFYHKLV 531
+ + + +T + V+ ++ + +I+ + +G+ GT EL + F KL+
Sbjct: 589 SCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 51.2 bits (117), Expect = 2e-05
Identities = 50/217 (23%), Positives = 90/217 (41%), Gaps = 22/217 (10%)
Query: 923 ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLR 982
+LK I+ +E G+ +A+ GS+G GK+++L +I +P+ G I+ G
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSG------------- 486
Query: 983 KQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXX--XHNFIVSLPKGYETN 1040
++ Q + T+ ENI +G + DE I +
Sbjct: 487 -RISFCSQFSWIMPGTIKENIIFG-----VSYDEYRYRSVIKACQLEEDISKFAEKDNIV 540
Query: 1041 XXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEA-LDHAAKGRTC 1099
+ R+ +ARA+ + L LLD LD +E+ + E+ + +T
Sbjct: 541 LGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTR 600
Query: 1100 ITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLK 1136
I + ++ +K AD I +L +G G +EL L+
Sbjct: 601 ILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQ 637
Score = 35.1 bits (77), Expect = 1.5
Identities = 33/116 (28%), Positives = 52/116 (44%), Gaps = 6/116 (5%)
Query: 682 GAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGS 741
G + R S D A + L I +Q + +G I ++ V+T +P++V
Sbjct: 970 GGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGAIAVVAVLQPYIFVAT--VPVIVAF 1026
Query: 742 IWLEGIMSQKSQQDEREAMESATAIATEAVVSIK---TVQSLGIESLFITRFQDAL 794
I L Q SQQ ++ E + I T V S+K T+++ G + F T F AL
Sbjct: 1027 IMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKAL 1082
>DQ388137-1|ABD72201.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 122 bits (294), Expect = 7e-27
Identities = 63/244 (25%), Positives = 132/244 (54%), Gaps = 3/244 (1%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G+++++D+ Y + IL+ S I PG+ V L+G +G GKST+L RL + +G
Sbjct: 1208 GQMTVKDLTAKYTEGGNA-ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN-TEG 1265
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+++DG + ++ + R + GV+ Q+ +F GT N+ Y + + +++++VA+
Sbjct: 1266 EIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGL 1324
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
I+ P + V+ + G LS G KQ + +ARS+L + +LLLDE ++ LDP + + +
Sbjct: 1325 RSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQII 1384
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSG 534
+ L +A T + HR+ ++ C + + +++ + + + +L+ + + + ++
Sbjct: 1385 RRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPS 1444
Query: 535 KETK 538
K
Sbjct: 1445 DRVK 1448
Score = 94.3 bits (224), Expect = 2e-18
Identities = 64/257 (24%), Positives = 119/257 (46%), Gaps = 8/257 (3%)
Query: 887 RIRTVDGLNDKQD--WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSG 944
++ ++ + K+D W + G ++ D+ Y T IL+ I + G+ V L+G +G
Sbjct: 1189 KVMIIENSHVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRVGLLGRTG 1247
Query: 945 CGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIA 1004
GKST+L R + T G I++DGV S+TL + RK GV+ Q+ +F T +N+
Sbjct: 1248 SGKSTLLSAFLRLLN-TEGEIQIDGVS-WDSITLQQWRKAFGVIPQKVFIFSGTFRKNL- 1304
Query: 1005 YGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIR 1064
D + + E + I P + KQ +C+AR+++
Sbjct: 1305 --DPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLS 1362
Query: 1065 SPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIV 1124
++LLLDE ++ LD + + + L A T I HR+ + + V+++ K+
Sbjct: 1363 KAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVR 1422
Query: 1125 EKGNHAELIGLKGHYWQ 1141
+ + +L+ + + Q
Sbjct: 1423 QYDSIQKLLNERSLFRQ 1439
Score = 87.8 bits (208), Expect = 2e-16
Identities = 64/237 (27%), Positives = 115/237 (48%), Gaps = 22/237 (9%)
Query: 300 EDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLD 359
+ + FS S +LK + I+ G+ +A+ GS+G GK+++L ++ +P++G +K
Sbjct: 426 DSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHS 485
Query: 360 GRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYR---VAEMAYAHE 416
GR W+ GTI +NI G S D YR V + E
Sbjct: 486 GRISFCSQFSWIMP-------------GTIKENIIFG----VSYDEYRYRSVIKACQLEE 528
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-Q 475
I V+GE G +LSGGQ+ RI++AR++ ++ + LLD LD +EK++ +
Sbjct: 529 DISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFE 588
Query: 476 AALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAK-GFYHKLV 531
+ + + +T + V+ ++ + +I+ + +G+ GT EL + F KL+
Sbjct: 589 SCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 51.2 bits (117), Expect = 2e-05
Identities = 50/217 (23%), Positives = 90/217 (41%), Gaps = 22/217 (10%)
Query: 923 ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLR 982
+LK I+ +E G+ +A+ GS+G GK+++L +I +P+ G I+ G
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSG------------- 486
Query: 983 KQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXX--XHNFIVSLPKGYETN 1040
++ Q + T+ ENI +G + DE I +
Sbjct: 487 -RISFCSQFSWIMPGTIKENIIFG-----VSYDEYRYRSVIKACQLEEDISKFAEKDNIV 540
Query: 1041 XXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEA-LDHAAKGRTC 1099
+ R+ +ARA+ + L LLD LD +E+ + E+ + +T
Sbjct: 541 LGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTR 600
Query: 1100 ITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLK 1136
I + ++ +K AD I +L +G G +EL L+
Sbjct: 601 ILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQ 637
Score = 35.1 bits (77), Expect = 1.5
Identities = 33/116 (28%), Positives = 52/116 (44%), Gaps = 6/116 (5%)
Query: 682 GAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGS 741
G + R S D A + L I +Q + +G I ++ V+T +P++V
Sbjct: 970 GGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGAIAVVAVLQPYIFVAT--VPVIVAF 1026
Query: 742 IWLEGIMSQKSQQDEREAMESATAIATEAVVSIK---TVQSLGIESLFITRFQDAL 794
I L Q SQQ ++ E + I T V S+K T+++ G + F T F AL
Sbjct: 1027 IMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKAL 1082
>DQ388135-1|ABD72197.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 122 bits (294), Expect = 7e-27
Identities = 63/244 (25%), Positives = 132/244 (54%), Gaps = 3/244 (1%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G+++++D+ Y + IL+ S I PG+ V L+G +G GKST+L RL + +G
Sbjct: 1208 GQMTVKDLTAKYTEGGNA-ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN-TEG 1265
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+++DG + ++ + R + GV+ Q+ +F GT N+ Y + + +++++VA+
Sbjct: 1266 EIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGL 1324
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
I+ P + V+ + G LS G KQ + +ARS+L + +LLLDE ++ LDP + + +
Sbjct: 1325 RSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQII 1384
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSG 534
+ L +A T + HR+ ++ C + + +++ + + + +L+ + + + ++
Sbjct: 1385 RRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPS 1444
Query: 535 KETK 538
K
Sbjct: 1445 DRVK 1448
Score = 94.3 bits (224), Expect = 2e-18
Identities = 64/257 (24%), Positives = 119/257 (46%), Gaps = 8/257 (3%)
Query: 887 RIRTVDGLNDKQD--WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSG 944
++ ++ + K+D W + G ++ D+ Y T IL+ I + G+ V L+G +G
Sbjct: 1189 KVMIIENSHVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRVGLLGRTG 1247
Query: 945 CGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIA 1004
GKST+L R + T G I++DGV S+TL + RK GV+ Q+ +F T +N+
Sbjct: 1248 SGKSTLLSAFLRLLN-TEGEIQIDGVS-WDSITLQQWRKAFGVIPQKVFIFSGTFRKNL- 1304
Query: 1005 YGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIR 1064
D + + E + I P + KQ +C+AR+++
Sbjct: 1305 --DPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLS 1362
Query: 1065 SPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIV 1124
++LLLDE ++ LD + + + L A T I HR+ + + V+++ K+
Sbjct: 1363 KAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVR 1422
Query: 1125 EKGNHAELIGLKGHYWQ 1141
+ + +L+ + + Q
Sbjct: 1423 QYDSIQKLLNERSLFRQ 1439
Score = 87.8 bits (208), Expect = 2e-16
Identities = 64/237 (27%), Positives = 115/237 (48%), Gaps = 22/237 (9%)
Query: 300 EDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLD 359
+ + FS S +LK + I+ G+ +A+ GS+G GK+++L ++ +P++G +K
Sbjct: 426 DSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHS 485
Query: 360 GRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYR---VAEMAYAHE 416
GR W+ GTI +NI G S D YR V + E
Sbjct: 486 GRISFCSQFSWIMP-------------GTIKENIIFG----VSYDEYRYRSVIKACQLEE 528
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-Q 475
I V+GE G +LSGGQ+ RI++AR++ ++ + LLD LD +EK++ +
Sbjct: 529 DISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFE 588
Query: 476 AALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAK-GFYHKLV 531
+ + + +T + V+ ++ + +I+ + +G+ GT EL + F KL+
Sbjct: 589 SCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 51.2 bits (117), Expect = 2e-05
Identities = 50/217 (23%), Positives = 90/217 (41%), Gaps = 22/217 (10%)
Query: 923 ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLR 982
+LK I+ +E G+ +A+ GS+G GK+++L +I +P+ G I+ G
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSG------------- 486
Query: 983 KQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXX--XHNFIVSLPKGYETN 1040
++ Q + T+ ENI +G + DE I +
Sbjct: 487 -RISFCSQFSWIMPGTIKENIIFG-----VSYDEYRYRSVIKACQLEEDISKFAEKDNIV 540
Query: 1041 XXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEA-LDHAAKGRTC 1099
+ R+ +ARA+ + L LLD LD +E+ + E+ + +T
Sbjct: 541 LGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTR 600
Query: 1100 ITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLK 1136
I + ++ +K AD I +L +G G +EL L+
Sbjct: 601 ILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQ 637
Score = 35.1 bits (77), Expect = 1.5
Identities = 33/116 (28%), Positives = 52/116 (44%), Gaps = 6/116 (5%)
Query: 682 GAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGS 741
G + R S D A + L I +Q + +G I ++ V+T +P++V
Sbjct: 970 GGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGAIAVVAVLQPYIFVAT--VPVIVAF 1026
Query: 742 IWLEGIMSQKSQQDEREAMESATAIATEAVVSIK---TVQSLGIESLFITRFQDAL 794
I L Q SQQ ++ E + I T V S+K T+++ G + F T F AL
Sbjct: 1027 IMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKAL 1082
>DQ388134-1|ABD72195.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 122 bits (294), Expect = 7e-27
Identities = 63/244 (25%), Positives = 132/244 (54%), Gaps = 3/244 (1%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G+++++D+ Y + IL+ S I PG+ V L+G +G GKST+L RL + +G
Sbjct: 1208 GQMTVKDLTAKYTEGGNA-ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN-TEG 1265
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+++DG + ++ + R + GV+ Q+ +F GT N+ Y + + +++++VA+
Sbjct: 1266 EIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGL 1324
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
I+ P + V+ + G LS G KQ + +ARS+L + +LLLDE ++ LDP + + +
Sbjct: 1325 RSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQII 1384
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSG 534
+ L +A T + HR+ ++ C + + +++ + + + +L+ + + + ++
Sbjct: 1385 RRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPS 1444
Query: 535 KETK 538
K
Sbjct: 1445 DRVK 1448
Score = 94.3 bits (224), Expect = 2e-18
Identities = 64/257 (24%), Positives = 119/257 (46%), Gaps = 8/257 (3%)
Query: 887 RIRTVDGLNDKQD--WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSG 944
++ ++ + K+D W + G ++ D+ Y T IL+ I + G+ V L+G +G
Sbjct: 1189 KVMIIENSHVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRVGLLGRTG 1247
Query: 945 CGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIA 1004
GKST+L R + T G I++DGV S+TL + RK GV+ Q+ +F T +N+
Sbjct: 1248 SGKSTLLSAFLRLLN-TEGEIQIDGVS-WDSITLQQWRKAFGVIPQKVFIFSGTFRKNL- 1304
Query: 1005 YGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIR 1064
D + + E + I P + KQ +C+AR+++
Sbjct: 1305 --DPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLS 1362
Query: 1065 SPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIV 1124
++LLLDE ++ LD + + + L A T I HR+ + + V+++ K+
Sbjct: 1363 KAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVR 1422
Query: 1125 EKGNHAELIGLKGHYWQ 1141
+ + +L+ + + Q
Sbjct: 1423 QYDSIQKLLNERSLFRQ 1439
Score = 87.4 bits (207), Expect = 3e-16
Identities = 64/237 (27%), Positives = 115/237 (48%), Gaps = 22/237 (9%)
Query: 300 EDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLD 359
+ + FS S +LK + I+ G+ +A+ GS+G GK+++L ++ +P++G +K
Sbjct: 426 DSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHS 485
Query: 360 GRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYR---VAEMAYAHE 416
GR W+ GTI +NI G S D YR V + E
Sbjct: 486 GRISFCSQFSWIMP-------------GTIKENIIFG----VSYDEYRYRSVIKACQLEE 528
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-Q 475
I V+GE G +LSGGQ+ RI++AR++ ++ + LLD LD +EK++ +
Sbjct: 529 DISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFE 588
Query: 476 AALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAK-GFYHKLV 531
+ + + +T + V+ ++ + +I+ + +G+ GT EL + F KL+
Sbjct: 589 SCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 50.8 bits (116), Expect = 3e-05
Identities = 50/217 (23%), Positives = 90/217 (41%), Gaps = 22/217 (10%)
Query: 923 ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLR 982
+LK I+ +E G+ +A+ GS+G GK+++L +I +P+ G I+ G
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG------------- 486
Query: 983 KQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXX--XHNFIVSLPKGYETN 1040
++ Q + T+ ENI +G + DE I +
Sbjct: 487 -RISFCSQFSWIMPGTIKENIIFG-----VSYDEYRYRSVIKACQLEEDISKFAEKDNIV 540
Query: 1041 XXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEA-LDHAAKGRTC 1099
+ R+ +ARA+ + L LLD LD +E+ + E+ + +T
Sbjct: 541 LGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTR 600
Query: 1100 ITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLK 1136
I + ++ +K AD I +L +G G +EL L+
Sbjct: 601 ILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQ 637
Score = 35.1 bits (77), Expect = 1.5
Identities = 33/116 (28%), Positives = 52/116 (44%), Gaps = 6/116 (5%)
Query: 682 GAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGS 741
G + R S D A + L I +Q + +G I ++ V+T +P++V
Sbjct: 970 GGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGAIAVVAVLQPYIFVAT--VPVIVAF 1026
Query: 742 IWLEGIMSQKSQQDEREAMESATAIATEAVVSIK---TVQSLGIESLFITRFQDAL 794
I L Q SQQ ++ E + I T V S+K T+++ G + F T F AL
Sbjct: 1027 IMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKAL 1082
>DQ388133-1|ABD72193.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 122 bits (294), Expect = 7e-27
Identities = 63/244 (25%), Positives = 132/244 (54%), Gaps = 3/244 (1%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G+++++D+ Y + IL+ S I PG+ V L+G +G GKST+L RL + +G
Sbjct: 1208 GQMTVKDLTAKYTEGGNA-ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN-TEG 1265
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+++DG + ++ + R + GV+ Q+ +F GT N+ Y + + +++++VA+
Sbjct: 1266 EIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGL 1324
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
I+ P + V+ + G LS G KQ + +ARS+L + +LLLDE ++ LDP + + +
Sbjct: 1325 RSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQII 1384
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSG 534
+ L +A T + HR+ ++ C + + +++ + + + +L+ + + + ++
Sbjct: 1385 RRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPS 1444
Query: 535 KETK 538
K
Sbjct: 1445 DRVK 1448
Score = 94.3 bits (224), Expect = 2e-18
Identities = 64/257 (24%), Positives = 119/257 (46%), Gaps = 8/257 (3%)
Query: 887 RIRTVDGLNDKQD--WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSG 944
++ ++ + K+D W + G ++ D+ Y T IL+ I + G+ V L+G +G
Sbjct: 1189 KVMIIENSHVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRVGLLGRTG 1247
Query: 945 CGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIA 1004
GKST+L R + T G I++DGV S+TL + RK GV+ Q+ +F T +N+
Sbjct: 1248 SGKSTLLSAFLRLLN-TEGEIQIDGVS-WDSITLQQWRKAFGVIPQKVFIFSGTFRKNL- 1304
Query: 1005 YGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIR 1064
D + + E + I P + KQ +C+AR+++
Sbjct: 1305 --DPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLS 1362
Query: 1065 SPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIV 1124
++LLLDE ++ LD + + + L A T I HR+ + + V+++ K+
Sbjct: 1363 KAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVR 1422
Query: 1125 EKGNHAELIGLKGHYWQ 1141
+ + +L+ + + Q
Sbjct: 1423 QYDSIQKLLNERSLFRQ 1439
Score = 87.8 bits (208), Expect = 2e-16
Identities = 64/237 (27%), Positives = 115/237 (48%), Gaps = 22/237 (9%)
Query: 300 EDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLD 359
+ + FS S +LK + I+ G+ +A+ GS+G GK+++L ++ +P++G +K
Sbjct: 426 DSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHS 485
Query: 360 GRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYR---VAEMAYAHE 416
GR W+ GTI +NI G S D YR V + E
Sbjct: 486 GRISFCSQFSWIMP-------------GTIKENIIFG----VSYDEYRYRSVIKACQLEE 528
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-Q 475
I V+GE G +LSGGQ+ RI++AR++ ++ + LLD LD +EK++ +
Sbjct: 529 DISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFE 588
Query: 476 AALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAK-GFYHKLV 531
+ + + +T + V+ ++ + +I+ + +G+ GT EL + F KL+
Sbjct: 589 SCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 51.2 bits (117), Expect = 2e-05
Identities = 50/217 (23%), Positives = 90/217 (41%), Gaps = 22/217 (10%)
Query: 923 ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLR 982
+LK I+ +E G+ +A+ GS+G GK+++L +I +P+ G I+ G
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSG------------- 486
Query: 983 KQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXX--XHNFIVSLPKGYETN 1040
++ Q + T+ ENI +G + DE I +
Sbjct: 487 -RISFCSQFSWIMPGTIKENIIFG-----VSYDEYRYRSVIKACQLEEDISKFAEKDNIV 540
Query: 1041 XXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEA-LDHAAKGRTC 1099
+ R+ +ARA+ + L LLD LD +E+ + E+ + +T
Sbjct: 541 LGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTR 600
Query: 1100 ITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLK 1136
I + ++ +K AD I +L +G G +EL L+
Sbjct: 601 ILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQ 637
Score = 35.1 bits (77), Expect = 1.5
Identities = 33/116 (28%), Positives = 52/116 (44%), Gaps = 6/116 (5%)
Query: 682 GAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGS 741
G + R S D A + L I +Q + +G I ++ V+T +P++V
Sbjct: 970 GGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGAIAVVAVLQPYIFVAT--VPVIVAF 1026
Query: 742 IWLEGIMSQKSQQDEREAMESATAIATEAVVSIK---TVQSLGIESLFITRFQDAL 794
I L Q SQQ ++ E + I T V S+K T+++ G + F T F AL
Sbjct: 1027 IMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKAL 1082
>DQ388132-1|ABD72191.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 122 bits (294), Expect = 7e-27
Identities = 63/244 (25%), Positives = 132/244 (54%), Gaps = 3/244 (1%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G+++++D+ Y + IL+ S I PG+ V L+G +G GKST+L RL + +G
Sbjct: 1208 GQMTVKDLTAKYTEGGNA-ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN-TEG 1265
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+++DG + ++ + R + GV+ Q+ +F GT N+ Y + + +++++VA+
Sbjct: 1266 EIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGL 1324
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
I+ P + V+ + G LS G KQ + +ARS+L + +LLLDE ++ LDP + + +
Sbjct: 1325 RSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQII 1384
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSG 534
+ L +A T + HR+ ++ C + + +++ + + + +L+ + + + ++
Sbjct: 1385 RRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPS 1444
Query: 535 KETK 538
K
Sbjct: 1445 DRVK 1448
Score = 94.3 bits (224), Expect = 2e-18
Identities = 64/257 (24%), Positives = 119/257 (46%), Gaps = 8/257 (3%)
Query: 887 RIRTVDGLNDKQD--WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSG 944
++ ++ + K+D W + G ++ D+ Y T IL+ I + G+ V L+G +G
Sbjct: 1189 KVMIIENSHVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRVGLLGRTG 1247
Query: 945 CGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIA 1004
GKST+L R + T G I++DGV S+TL + RK GV+ Q+ +F T +N+
Sbjct: 1248 SGKSTLLSAFLRLLN-TEGEIQIDGVS-WDSITLQQWRKAFGVIPQKVFIFSGTFRKNL- 1304
Query: 1005 YGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIR 1064
D + + E + I P + KQ +C+AR+++
Sbjct: 1305 --DPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLS 1362
Query: 1065 SPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIV 1124
++LLLDE ++ LD + + + L A T I HR+ + + V+++ K+
Sbjct: 1363 KAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVR 1422
Query: 1125 EKGNHAELIGLKGHYWQ 1141
+ + +L+ + + Q
Sbjct: 1423 QYDSIQKLLNERSLFRQ 1439
Score = 87.8 bits (208), Expect = 2e-16
Identities = 64/237 (27%), Positives = 115/237 (48%), Gaps = 22/237 (9%)
Query: 300 EDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLD 359
+ + FS S +LK + I+ G+ +A+ GS+G GK+++L ++ +P++G +K
Sbjct: 426 DSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHS 485
Query: 360 GRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYR---VAEMAYAHE 416
GR W+ GTI +NI G S D YR V + E
Sbjct: 486 GRISFCSQFSWIMP-------------GTIKENIIFG----VSYDEYRYRSVIKACQLEE 528
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-Q 475
I V+GE G +LSGGQ+ RI++AR++ ++ + LLD LD +EK++ +
Sbjct: 529 DISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFE 588
Query: 476 AALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAK-GFYHKLV 531
+ + + +T + V+ ++ + +I+ + +G+ GT EL + F KL+
Sbjct: 589 SCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 51.2 bits (117), Expect = 2e-05
Identities = 50/217 (23%), Positives = 90/217 (41%), Gaps = 22/217 (10%)
Query: 923 ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLR 982
+LK I+ +E G+ +A+ GS+G GK+++L +I +P+ G I+ G
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSG------------- 486
Query: 983 KQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXX--XHNFIVSLPKGYETN 1040
++ Q + T+ ENI +G + DE I +
Sbjct: 487 -RISFCSQFSWIMPGTIKENIIFG-----VSYDEYRYRSVIKACQLEEDISKFAEKDNIV 540
Query: 1041 XXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEA-LDHAAKGRTC 1099
+ R+ +ARA+ + L LLD LD +E+ + E+ + +T
Sbjct: 541 LGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTR 600
Query: 1100 ITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLK 1136
I + ++ +K AD I +L +G G +EL L+
Sbjct: 601 ILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQ 637
Score = 35.1 bits (77), Expect = 1.5
Identities = 33/116 (28%), Positives = 52/116 (44%), Gaps = 6/116 (5%)
Query: 682 GAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGS 741
G + R S D A + L I +Q + +G I ++ V+T +P++V
Sbjct: 970 GGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGAIAVVAVLQPYIFVAT--VPVIVAF 1026
Query: 742 IWLEGIMSQKSQQDEREAMESATAIATEAVVSIK---TVQSLGIESLFITRFQDAL 794
I L Q SQQ ++ E + I T V S+K T+++ G + F T F AL
Sbjct: 1027 IMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKAL 1082
>DQ388131-1|ABD72189.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 122 bits (294), Expect = 7e-27
Identities = 63/244 (25%), Positives = 132/244 (54%), Gaps = 3/244 (1%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G+++++D+ Y + IL+ S I PG+ V L+G +G GKST+L RL + +G
Sbjct: 1208 GQMTVKDLTAKYTEGGNA-ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN-TEG 1265
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+++DG + ++ + R + GV+ Q+ +F GT N+ Y + + +++++VA+
Sbjct: 1266 EIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGL 1324
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
I+ P + V+ + G LS G KQ + +ARS+L + +LLLDE ++ LDP + + +
Sbjct: 1325 RSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQII 1384
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSG 534
+ L +A T + HR+ ++ C + + +++ + + + +L+ + + + ++
Sbjct: 1385 RRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPS 1444
Query: 535 KETK 538
K
Sbjct: 1445 DRVK 1448
Score = 94.3 bits (224), Expect = 2e-18
Identities = 64/257 (24%), Positives = 119/257 (46%), Gaps = 8/257 (3%)
Query: 887 RIRTVDGLNDKQD--WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSG 944
++ ++ + K+D W + G ++ D+ Y T IL+ I + G+ V L+G +G
Sbjct: 1189 KVMIIENSHVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRVGLLGRTG 1247
Query: 945 CGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIA 1004
GKST+L R + T G I++DGV S+TL + RK GV+ Q+ +F T +N+
Sbjct: 1248 SGKSTLLSAFLRLLN-TEGEIQIDGVS-WDSITLQQWRKAFGVIPQKVFIFSGTFRKNL- 1304
Query: 1005 YGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIR 1064
D + + E + I P + KQ +C+AR+++
Sbjct: 1305 --DPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLS 1362
Query: 1065 SPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIV 1124
++LLLDE ++ LD + + + L A T I HR+ + + V+++ K+
Sbjct: 1363 KAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVR 1422
Query: 1125 EKGNHAELIGLKGHYWQ 1141
+ + +L+ + + Q
Sbjct: 1423 QYDSIQKLLNERSLFRQ 1439
Score = 87.8 bits (208), Expect = 2e-16
Identities = 64/237 (27%), Positives = 115/237 (48%), Gaps = 22/237 (9%)
Query: 300 EDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLD 359
+ + FS S +LK + I+ G+ +A+ GS+G GK+++L ++ +P++G +K
Sbjct: 426 DSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHS 485
Query: 360 GRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYR---VAEMAYAHE 416
GR W+ GTI +NI G S D YR V + E
Sbjct: 486 GRISFCSQFSWIMP-------------GTIKENIIFG----VSYDEYRYRSVIKACQLEE 528
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-Q 475
I V+GE G +LSGGQ+ RI++AR++ ++ + LLD LD +EK++ +
Sbjct: 529 DISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFE 588
Query: 476 AALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAK-GFYHKLV 531
+ + + +T + V+ ++ + +I+ + +G+ GT EL + F KL+
Sbjct: 589 SCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 51.2 bits (117), Expect = 2e-05
Identities = 50/217 (23%), Positives = 90/217 (41%), Gaps = 22/217 (10%)
Query: 923 ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLR 982
+LK I+ +E G+ +A+ GS+G GK+++L +I +P+ G I+ G
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSG------------- 486
Query: 983 KQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXX--XHNFIVSLPKGYETN 1040
++ Q + T+ ENI +G + DE I +
Sbjct: 487 -RISFCSQFSWIMPGTIKENIIFG-----VSYDEYRYRSVIKACQLEEDISKFAEKDNIV 540
Query: 1041 XXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEA-LDHAAKGRTC 1099
+ R+ +ARA+ + L LLD LD +E+ + E+ + +T
Sbjct: 541 LGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTR 600
Query: 1100 ITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLK 1136
I + ++ +K AD I +L +G G +EL L+
Sbjct: 601 ILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQ 637
Score = 35.1 bits (77), Expect = 1.5
Identities = 33/116 (28%), Positives = 52/116 (44%), Gaps = 6/116 (5%)
Query: 682 GAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGS 741
G + R S D A + L I +Q + +G I ++ V+T +P++V
Sbjct: 970 GGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGAIAVVAVLQPYIFVAT--VPVIVAF 1026
Query: 742 IWLEGIMSQKSQQDEREAMESATAIATEAVVSIK---TVQSLGIESLFITRFQDAL 794
I L Q SQQ ++ E + I T V S+K T+++ G + F T F AL
Sbjct: 1027 IMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKAL 1082
>DQ388130-1|ABD72187.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 122 bits (294), Expect = 7e-27
Identities = 63/244 (25%), Positives = 132/244 (54%), Gaps = 3/244 (1%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G+++++D+ Y + IL+ S I PG+ V L+G +G GKST+L RL + +G
Sbjct: 1208 GQMTVKDLTAKYTEGGNA-ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN-TEG 1265
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+++DG + ++ + R + GV+ Q+ +F GT N+ Y + + +++++VA+
Sbjct: 1266 EIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGL 1324
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
I+ P + V+ + G LS G KQ + +ARS+L + +LLLDE ++ LDP + + +
Sbjct: 1325 RSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQII 1384
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSG 534
+ L +A T + HR+ ++ C + + +++ + + + +L+ + + + ++
Sbjct: 1385 RRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPS 1444
Query: 535 KETK 538
K
Sbjct: 1445 DRVK 1448
Score = 94.3 bits (224), Expect = 2e-18
Identities = 64/257 (24%), Positives = 119/257 (46%), Gaps = 8/257 (3%)
Query: 887 RIRTVDGLNDKQD--WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSG 944
++ ++ + K+D W + G ++ D+ Y T IL+ I + G+ V L+G +G
Sbjct: 1189 KVMIIENSHVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRVGLLGRTG 1247
Query: 945 CGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIA 1004
GKST+L R + T G I++DGV S+TL + RK GV+ Q+ +F T +N+
Sbjct: 1248 SGKSTLLSAFLRLLN-TEGEIQIDGVS-WDSITLQQWRKAFGVIPQKVFIFSGTFRKNL- 1304
Query: 1005 YGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIR 1064
D + + E + I P + KQ +C+AR+++
Sbjct: 1305 --DPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLS 1362
Query: 1065 SPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIV 1124
++LLLDE ++ LD + + + L A T I HR+ + + V+++ K+
Sbjct: 1363 KAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVR 1422
Query: 1125 EKGNHAELIGLKGHYWQ 1141
+ + +L+ + + Q
Sbjct: 1423 QYDSIQKLLNERSLFRQ 1439
Score = 87.8 bits (208), Expect = 2e-16
Identities = 64/237 (27%), Positives = 115/237 (48%), Gaps = 22/237 (9%)
Query: 300 EDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLD 359
+ + FS S +LK + I+ G+ +A+ GS+G GK+++L ++ +P++G +K
Sbjct: 426 DSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHS 485
Query: 360 GRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYR---VAEMAYAHE 416
GR W+ GTI +NI G S D YR V + E
Sbjct: 486 GRISFCSQFSWIMP-------------GTIKENIIFG----VSYDEYRYRSVIKACQLEE 528
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-Q 475
I V+GE G +LSGGQ+ RI++AR++ ++ + LLD LD +EK++ +
Sbjct: 529 DISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFE 588
Query: 476 AALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAK-GFYHKLV 531
+ + + +T + V+ ++ + +I+ + +G+ GT EL + F KL+
Sbjct: 589 SCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 51.2 bits (117), Expect = 2e-05
Identities = 50/217 (23%), Positives = 90/217 (41%), Gaps = 22/217 (10%)
Query: 923 ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLR 982
+LK I+ +E G+ +A+ GS+G GK+++L +I +P+ G I+ G
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSG------------- 486
Query: 983 KQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXX--XHNFIVSLPKGYETN 1040
++ Q + T+ ENI +G + DE I +
Sbjct: 487 -RISFCSQFSWIMPGTIKENIIFG-----VSYDEYRYRSVIKACQLEEDISKFAEKDNIV 540
Query: 1041 XXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEA-LDHAAKGRTC 1099
+ R+ +ARA+ + L LLD LD +E+ + E+ + +T
Sbjct: 541 LGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTR 600
Query: 1100 ITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLK 1136
I + ++ +K AD I +L +G G +EL L+
Sbjct: 601 ILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQ 637
Score = 35.1 bits (77), Expect = 1.5
Identities = 33/116 (28%), Positives = 52/116 (44%), Gaps = 6/116 (5%)
Query: 682 GAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGS 741
G + R S D A + L I +Q + +G I ++ V+T +P++V
Sbjct: 970 GGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGAIAVVAVLQPYIFVAT--VPVIVAF 1026
Query: 742 IWLEGIMSQKSQQDEREAMESATAIATEAVVSIK---TVQSLGIESLFITRFQDAL 794
I L Q SQQ ++ E + I T V S+K T+++ G + F T F AL
Sbjct: 1027 IMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKAL 1082
>DQ388129-1|ABD72185.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 122 bits (294), Expect = 7e-27
Identities = 63/244 (25%), Positives = 132/244 (54%), Gaps = 3/244 (1%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G+++++D+ Y + IL+ S I PG+ V L+G +G GKST+L RL + +G
Sbjct: 1208 GQMTVKDLTAKYTEGGNA-ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN-TEG 1265
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+++DG + ++ + R + GV+ Q+ +F GT N+ Y + + +++++VA+
Sbjct: 1266 EIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGL 1324
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
I+ P + V+ + G LS G KQ + +ARS+L + +LLLDE ++ LDP + + +
Sbjct: 1325 RSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQII 1384
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSG 534
+ L +A T + HR+ ++ C + + +++ + + + +L+ + + + ++
Sbjct: 1385 RRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPS 1444
Query: 535 KETK 538
K
Sbjct: 1445 DRVK 1448
Score = 94.3 bits (224), Expect = 2e-18
Identities = 64/257 (24%), Positives = 119/257 (46%), Gaps = 8/257 (3%)
Query: 887 RIRTVDGLNDKQD--WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSG 944
++ ++ + K+D W + G ++ D+ Y T IL+ I + G+ V L+G +G
Sbjct: 1189 KVMIIENSHVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRVGLLGRTG 1247
Query: 945 CGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIA 1004
GKST+L R + T G I++DGV S+TL + RK GV+ Q+ +F T +N+
Sbjct: 1248 SGKSTLLSAFLRLLN-TEGEIQIDGVS-WDSITLQQWRKAFGVIPQKVFIFSGTFRKNL- 1304
Query: 1005 YGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIR 1064
D + + E + I P + KQ +C+AR+++
Sbjct: 1305 --DPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLS 1362
Query: 1065 SPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIV 1124
++LLLDE ++ LD + + + L A T I HR+ + + V+++ K+
Sbjct: 1363 KAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVR 1422
Query: 1125 EKGNHAELIGLKGHYWQ 1141
+ + +L+ + + Q
Sbjct: 1423 QYDSIQKLLNERSLFRQ 1439
Score = 87.8 bits (208), Expect = 2e-16
Identities = 64/237 (27%), Positives = 115/237 (48%), Gaps = 22/237 (9%)
Query: 300 EDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLD 359
+ + FS S +LK + I+ G+ +A+ GS+G GK+++L ++ +P++G +K
Sbjct: 426 DSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHS 485
Query: 360 GRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYR---VAEMAYAHE 416
GR W+ GTI +NI G S D YR V + E
Sbjct: 486 GRISFCSQFSWIMP-------------GTIKENIIFG----VSYDEYRYRSVIKACQLEE 528
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-Q 475
I V+GE G +LSGGQ+ RI++AR++ ++ + LLD LD +EK++ +
Sbjct: 529 DISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFE 588
Query: 476 AALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAK-GFYHKLV 531
+ + + +T + V+ ++ + +I+ + +G+ GT EL + F KL+
Sbjct: 589 SCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 51.2 bits (117), Expect = 2e-05
Identities = 50/217 (23%), Positives = 90/217 (41%), Gaps = 22/217 (10%)
Query: 923 ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLR 982
+LK I+ +E G+ +A+ GS+G GK+++L +I +P+ G I+ G
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSG------------- 486
Query: 983 KQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXX--XHNFIVSLPKGYETN 1040
++ Q + T+ ENI +G + DE I +
Sbjct: 487 -RISFCSQFSWIMPGTIKENIIFG-----VSYDEYRYRSVIKACQLEEDISKFAEKDNIV 540
Query: 1041 XXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEA-LDHAAKGRTC 1099
+ R+ +ARA+ + L LLD LD +E+ + E+ + +T
Sbjct: 541 LGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTR 600
Query: 1100 ITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLK 1136
I + ++ +K AD I +L +G G +EL L+
Sbjct: 601 ILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQ 637
Score = 35.1 bits (77), Expect = 1.5
Identities = 33/116 (28%), Positives = 52/116 (44%), Gaps = 6/116 (5%)
Query: 682 GAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGS 741
G + R S D A + L I +Q + +G I ++ V+T +P++V
Sbjct: 970 GGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGAIAVVAVLQPYIFVAT--VPVIVAF 1026
Query: 742 IWLEGIMSQKSQQDEREAMESATAIATEAVVSIK---TVQSLGIESLFITRFQDAL 794
I L Q SQQ ++ E + I T V S+K T+++ G + F T F AL
Sbjct: 1027 IMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKAL 1082
>DQ388128-1|ABD72183.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 122 bits (294), Expect = 7e-27
Identities = 63/244 (25%), Positives = 132/244 (54%), Gaps = 3/244 (1%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G+++++D+ Y + IL+ S I PG+ V L+G +G GKST+L RL + +G
Sbjct: 1208 GQMTVKDLTAKYTEGGNA-ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN-TEG 1265
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+++DG + ++ + R + GV+ Q+ +F GT N+ Y + + +++++VA+
Sbjct: 1266 EIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGL 1324
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
I+ P + V+ + G LS G KQ + +ARS+L + +LLLDE ++ LDP + + +
Sbjct: 1325 RSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQII 1384
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSG 534
+ L +A T + HR+ ++ C + + +++ + + + +L+ + + + ++
Sbjct: 1385 RRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPS 1444
Query: 535 KETK 538
K
Sbjct: 1445 DRVK 1448
Score = 94.3 bits (224), Expect = 2e-18
Identities = 64/257 (24%), Positives = 119/257 (46%), Gaps = 8/257 (3%)
Query: 887 RIRTVDGLNDKQD--WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSG 944
++ ++ + K+D W + G ++ D+ Y T IL+ I + G+ V L+G +G
Sbjct: 1189 KVMIIENSHVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRVGLLGRTG 1247
Query: 945 CGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIA 1004
GKST+L R + T G I++DGV S+TL + RK GV+ Q+ +F T +N+
Sbjct: 1248 SGKSTLLSAFLRLLN-TEGEIQIDGVS-WDSITLQQWRKAFGVIPQKVFIFSGTFRKNL- 1304
Query: 1005 YGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIR 1064
D + + E + I P + KQ +C+AR+++
Sbjct: 1305 --DPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLS 1362
Query: 1065 SPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIV 1124
++LLLDE ++ LD + + + L A T I HR+ + + V+++ K+
Sbjct: 1363 KAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVR 1422
Query: 1125 EKGNHAELIGLKGHYWQ 1141
+ + +L+ + + Q
Sbjct: 1423 QYDSIQKLLNERSLFRQ 1439
Score = 87.8 bits (208), Expect = 2e-16
Identities = 64/237 (27%), Positives = 115/237 (48%), Gaps = 22/237 (9%)
Query: 300 EDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLD 359
+ + FS S +LK + I+ G+ +A+ GS+G GK+++L ++ +P++G +K
Sbjct: 426 DSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHS 485
Query: 360 GRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYR---VAEMAYAHE 416
GR W+ GTI +NI G S D YR V + E
Sbjct: 486 GRISFCSQFSWIMP-------------GTIKENIIFG----VSYDEYRYRSVIKACQLEE 528
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-Q 475
I V+GE G +LSGGQ+ RI++AR++ ++ + LLD LD +EK++ +
Sbjct: 529 DISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFE 588
Query: 476 AALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAK-GFYHKLV 531
+ + + +T + V+ ++ + +I+ + +G+ GT EL + F KL+
Sbjct: 589 SCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 51.2 bits (117), Expect = 2e-05
Identities = 50/217 (23%), Positives = 90/217 (41%), Gaps = 22/217 (10%)
Query: 923 ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLR 982
+LK I+ +E G+ +A+ GS+G GK+++L +I +P+ G I+ G
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSG------------- 486
Query: 983 KQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXX--XHNFIVSLPKGYETN 1040
++ Q + T+ ENI +G + DE I +
Sbjct: 487 -RISFCSQFSWIMPGTIKENIIFG-----VSYDEYRYRSVIKACQLEEDISKFAEKDNIV 540
Query: 1041 XXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEA-LDHAAKGRTC 1099
+ R+ +ARA+ + L LLD LD +E+ + E+ + +T
Sbjct: 541 LGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTR 600
Query: 1100 ITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLK 1136
I + ++ +K AD I +L +G G +EL L+
Sbjct: 601 ILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQ 637
Score = 35.1 bits (77), Expect = 1.5
Identities = 33/116 (28%), Positives = 52/116 (44%), Gaps = 6/116 (5%)
Query: 682 GAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGS 741
G + R S D A + L I +Q + +G I ++ V+T +P++V
Sbjct: 970 GGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGAIAVVAVLQPYIFVAT--VPVIVAF 1026
Query: 742 IWLEGIMSQKSQQDEREAMESATAIATEAVVSIK---TVQSLGIESLFITRFQDAL 794
I L Q SQQ ++ E + I T V S+K T+++ G + F T F AL
Sbjct: 1027 IMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKAL 1082
>DQ356264-1|ABC87067.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 122 bits (294), Expect = 7e-27
Identities = 63/244 (25%), Positives = 132/244 (54%), Gaps = 3/244 (1%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G+++++D+ Y + IL+ S I PG+ V L+G +G GKST+L RL + +G
Sbjct: 1208 GQMTVKDLTAKYTEGGNA-ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN-TEG 1265
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+++DG + ++ + R + GV+ Q+ +F GT N+ Y + + +++++VA+
Sbjct: 1266 EIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGL 1324
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
I+ P + V+ + G LS G KQ + +ARS+L + +LLLDE ++ LDP + + +
Sbjct: 1325 RSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQII 1384
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSG 534
+ L +A T + HR+ ++ C + + +++ + + + +L+ + + + ++
Sbjct: 1385 RRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPS 1444
Query: 535 KETK 538
K
Sbjct: 1445 DRVK 1448
Score = 94.3 bits (224), Expect = 2e-18
Identities = 64/257 (24%), Positives = 119/257 (46%), Gaps = 8/257 (3%)
Query: 887 RIRTVDGLNDKQD--WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSG 944
++ ++ + K+D W + G ++ D+ Y T IL+ I + G+ V L+G +G
Sbjct: 1189 KVMIIENSHVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRVGLLGRTG 1247
Query: 945 CGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIA 1004
GKST+L R + T G I++DGV S+TL + RK GV+ Q+ +F T +N+
Sbjct: 1248 SGKSTLLSAFLRLLN-TEGEIQIDGVS-WDSITLQQWRKAFGVIPQKVFIFSGTFRKNL- 1304
Query: 1005 YGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIR 1064
D + + E + I P + KQ +C+AR+++
Sbjct: 1305 --DPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLS 1362
Query: 1065 SPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIV 1124
++LLLDE ++ LD + + + L A T I HR+ + + V+++ K+
Sbjct: 1363 KAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVR 1422
Query: 1125 EKGNHAELIGLKGHYWQ 1141
+ + +L+ + + Q
Sbjct: 1423 QYDSIQKLLNERSLFRQ 1439
Score = 87.8 bits (208), Expect = 2e-16
Identities = 64/237 (27%), Positives = 115/237 (48%), Gaps = 22/237 (9%)
Query: 300 EDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLD 359
+ + FS S +LK + I+ G+ +A+ GS+G GK+++L ++ +P++G +K
Sbjct: 426 DSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHS 485
Query: 360 GRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYR---VAEMAYAHE 416
GR W+ GTI +NI G S D YR V + E
Sbjct: 486 GRISFCSQFSWIMP-------------GTIKENIIFG----VSYDEYRYRSVIKACQLEE 528
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-Q 475
I V+GE G +LSGGQ+ RI++AR++ ++ + LLD LD +EK++ +
Sbjct: 529 DISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFE 588
Query: 476 AALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAK-GFYHKLV 531
+ + + +T + V+ ++ + +I+ + +G+ GT EL + F KL+
Sbjct: 589 SCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 51.2 bits (117), Expect = 2e-05
Identities = 50/217 (23%), Positives = 90/217 (41%), Gaps = 22/217 (10%)
Query: 923 ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLR 982
+LK I+ +E G+ +A+ GS+G GK+++L +I +P+ G I+ G
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSG------------- 486
Query: 983 KQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXX--XHNFIVSLPKGYETN 1040
++ Q + T+ ENI +G + DE I +
Sbjct: 487 -RISFCSQFSWIMPGTIKENIIFG-----VSYDEYRYRSVIKACQLEEDISKFAEKDNIV 540
Query: 1041 XXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEA-LDHAAKGRTC 1099
+ R+ +ARA+ + L LLD LD +E+ + E+ + +T
Sbjct: 541 LGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTR 600
Query: 1100 ITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLK 1136
I + ++ +K AD I +L +G G +EL L+
Sbjct: 601 ILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQ 637
Score = 35.1 bits (77), Expect = 1.5
Identities = 33/116 (28%), Positives = 52/116 (44%), Gaps = 6/116 (5%)
Query: 682 GAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGS 741
G + R S D A + L I +Q + +G I ++ V+T +P++V
Sbjct: 970 GGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGAIAVVAVLQPYIFVAT--VPVIVAF 1026
Query: 742 IWLEGIMSQKSQQDEREAMESATAIATEAVVSIK---TVQSLGIESLFITRFQDAL 794
I L Q SQQ ++ E + I T V S+K T+++ G + F T F AL
Sbjct: 1027 IMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKAL 1082
>DQ356263-1|ABC87065.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 122 bits (294), Expect = 7e-27
Identities = 63/244 (25%), Positives = 132/244 (54%), Gaps = 3/244 (1%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G+++++D+ Y + IL+ S I PG+ V L+G +G GKST+L RL + +G
Sbjct: 1208 GQMTVKDLTAKYTEGGNA-ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN-TEG 1265
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+++DG + ++ + R + GV+ Q+ +F GT N+ Y + + +++++VA+
Sbjct: 1266 EIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGL 1324
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
I+ P + V+ + G LS G KQ + +ARS+L + +LLLDE ++ LDP + + +
Sbjct: 1325 RSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQII 1384
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSG 534
+ L +A T + HR+ ++ C + + +++ + + + +L+ + + + ++
Sbjct: 1385 RRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPS 1444
Query: 535 KETK 538
K
Sbjct: 1445 DRVK 1448
Score = 94.3 bits (224), Expect = 2e-18
Identities = 64/257 (24%), Positives = 119/257 (46%), Gaps = 8/257 (3%)
Query: 887 RIRTVDGLNDKQD--WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSG 944
++ ++ + K+D W + G ++ D+ Y T IL+ I + G+ V L+G +G
Sbjct: 1189 KVMIIENSHVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRVGLLGRTG 1247
Query: 945 CGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIA 1004
GKST+L R + T G I++DGV S+TL + RK GV+ Q+ +F T +N+
Sbjct: 1248 SGKSTLLSAFLRLLN-TEGEIQIDGVS-WDSITLQQWRKAFGVIPQKVFIFSGTFRKNL- 1304
Query: 1005 YGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIR 1064
D + + E + I P + KQ +C+AR+++
Sbjct: 1305 --DPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLS 1362
Query: 1065 SPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIV 1124
++LLLDE ++ LD + + + L A T I HR+ + + V+++ K+
Sbjct: 1363 KAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVR 1422
Query: 1125 EKGNHAELIGLKGHYWQ 1141
+ + +L+ + + Q
Sbjct: 1423 QYDSIQKLLNERSLFRQ 1439
Score = 87.8 bits (208), Expect = 2e-16
Identities = 64/237 (27%), Positives = 115/237 (48%), Gaps = 22/237 (9%)
Query: 300 EDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLD 359
+ + FS S +LK + I+ G+ +A+ GS+G GK+++L ++ +P++G +K
Sbjct: 426 DSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHS 485
Query: 360 GRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYR---VAEMAYAHE 416
GR W+ GTI +NI G S D YR V + E
Sbjct: 486 GRISFCSQFSWIMP-------------GTIKENIIFG----VSYDEYRYRSVIKACQLEE 528
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-Q 475
I V+GE G +LSGGQ+ RI++AR++ ++ + LLD LD +EK++ +
Sbjct: 529 DISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFE 588
Query: 476 AALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAK-GFYHKLV 531
+ + + +T + V+ ++ + +I+ + +G+ GT EL + F KL+
Sbjct: 589 SCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 51.2 bits (117), Expect = 2e-05
Identities = 50/217 (23%), Positives = 90/217 (41%), Gaps = 22/217 (10%)
Query: 923 ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLR 982
+LK I+ +E G+ +A+ GS+G GK+++L +I +P+ G I+ G
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSG------------- 486
Query: 983 KQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXX--XHNFIVSLPKGYETN 1040
++ Q + T+ ENI +G + DE I +
Sbjct: 487 -RISFCSQFSWIMPGTIKENIIFG-----VSYDEYRYRSVIKACQLEEDISKFAEKDNIV 540
Query: 1041 XXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEA-LDHAAKGRTC 1099
+ R+ +ARA+ + L LLD LD +E+ + E+ + +T
Sbjct: 541 LGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTR 600
Query: 1100 ITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLK 1136
I + ++ +K AD I +L +G G +EL L+
Sbjct: 601 ILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQ 637
Score = 35.1 bits (77), Expect = 1.5
Identities = 33/116 (28%), Positives = 52/116 (44%), Gaps = 6/116 (5%)
Query: 682 GAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGS 741
G + R S D A + L I +Q + +G I ++ V+T +P++V
Sbjct: 970 GGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGAIAVVAVLQPYIFVAT--VPVIVAF 1026
Query: 742 IWLEGIMSQKSQQDEREAMESATAIATEAVVSIK---TVQSLGIESLFITRFQDAL 794
I L Q SQQ ++ E + I T V S+K T+++ G + F T F AL
Sbjct: 1027 IMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKAL 1082
>DQ356262-1|ABC87063.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 122 bits (294), Expect = 7e-27
Identities = 63/244 (25%), Positives = 132/244 (54%), Gaps = 3/244 (1%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G+++++D+ Y + IL+ S I PG+ V L+G +G GKST+L RL + +G
Sbjct: 1208 GQMTVKDLTAKYTEGGNA-ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN-TEG 1265
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+++DG + ++ + R + GV+ Q+ +F GT N+ Y + + +++++VA+
Sbjct: 1266 EIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGL 1324
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
I+ P + V+ + G LS G KQ + +ARS+L + +LLLDE ++ LDP + + +
Sbjct: 1325 RSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQII 1384
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSG 534
+ L +A T + HR+ ++ C + + +++ + + + +L+ + + + ++
Sbjct: 1385 RRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPS 1444
Query: 535 KETK 538
K
Sbjct: 1445 DRVK 1448
Score = 94.3 bits (224), Expect = 2e-18
Identities = 64/257 (24%), Positives = 119/257 (46%), Gaps = 8/257 (3%)
Query: 887 RIRTVDGLNDKQD--WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSG 944
++ ++ + K+D W + G ++ D+ Y T IL+ I + G+ V L+G +G
Sbjct: 1189 KVMIIENSHVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRVGLLGRTG 1247
Query: 945 CGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIA 1004
GKST+L R + T G I++DGV S+TL + RK GV+ Q+ +F T +N+
Sbjct: 1248 SGKSTLLSAFLRLLN-TEGEIQIDGVS-WDSITLQQWRKAFGVIPQKVFIFSGTFRKNL- 1304
Query: 1005 YGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIR 1064
D + + E + I P + KQ +C+AR+++
Sbjct: 1305 --DPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLS 1362
Query: 1065 SPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIV 1124
++LLLDE ++ LD + + + L A T I HR+ + + V+++ K+
Sbjct: 1363 KAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVR 1422
Query: 1125 EKGNHAELIGLKGHYWQ 1141
+ + +L+ + + Q
Sbjct: 1423 QYDSIQKLLNERSLFRQ 1439
Score = 87.8 bits (208), Expect = 2e-16
Identities = 64/237 (27%), Positives = 115/237 (48%), Gaps = 22/237 (9%)
Query: 300 EDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLD 359
+ + FS S +LK + I+ G+ +A+ GS+G GK+++L ++ +P++G +K
Sbjct: 426 DSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHS 485
Query: 360 GRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYR---VAEMAYAHE 416
GR W+ GTI +NI G S D YR V + E
Sbjct: 486 GRISFCSQFSWIMP-------------GTIKENIIFG----VSYDEYRYRSVIKACQLEE 528
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-Q 475
I V+GE G +LSGGQ+ RI++AR++ ++ + LLD LD +EK++ +
Sbjct: 529 DISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFE 588
Query: 476 AALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAK-GFYHKLV 531
+ + + +T + V+ ++ + +I+ + +G+ GT EL + F KL+
Sbjct: 589 SCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 51.2 bits (117), Expect = 2e-05
Identities = 50/217 (23%), Positives = 90/217 (41%), Gaps = 22/217 (10%)
Query: 923 ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLR 982
+LK I+ +E G+ +A+ GS+G GK+++L +I +P+ G I+ G
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSG------------- 486
Query: 983 KQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXX--XHNFIVSLPKGYETN 1040
++ Q + T+ ENI +G + DE I +
Sbjct: 487 -RISFCSQFSWIMPGTIKENIIFG-----VSYDEYRYRSVIKACQLEEDISKFAEKDNIV 540
Query: 1041 XXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEA-LDHAAKGRTC 1099
+ R+ +ARA+ + L LLD LD +E+ + E+ + +T
Sbjct: 541 LGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTR 600
Query: 1100 ITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLK 1136
I + ++ +K AD I +L +G G +EL L+
Sbjct: 601 ILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQ 637
Score = 35.1 bits (77), Expect = 1.5
Identities = 33/116 (28%), Positives = 52/116 (44%), Gaps = 6/116 (5%)
Query: 682 GAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGS 741
G + R S D A + L I +Q + +G I ++ V+T +P++V
Sbjct: 970 GGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGAIAVVAVLQPYIFVAT--VPVIVAF 1026
Query: 742 IWLEGIMSQKSQQDEREAMESATAIATEAVVSIK---TVQSLGIESLFITRFQDAL 794
I L Q SQQ ++ E + I T V S+K T+++ G + F T F AL
Sbjct: 1027 IMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKAL 1082
>DQ356261-1|ABC87061.1| 1462|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1462
Score = 122 bits (294), Expect = 7e-27
Identities = 63/244 (25%), Positives = 132/244 (54%), Gaps = 3/244 (1%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G+++++D+ Y + IL+ S I PG+ V L+G +G GKST+L RL + +G
Sbjct: 1190 GQMTVKDLTAKYTEGGNA-ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN-TEG 1247
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+++DG + ++ + R + GV+ Q+ +F GT N+ Y + + +++++VA+
Sbjct: 1248 EIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGL 1306
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
I+ P + V+ + G LS G KQ + +ARS+L + +LLLDE ++ LDP + + +
Sbjct: 1307 RSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQII 1366
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSG 534
+ L +A T + HR+ ++ C + + +++ + + + +L+ + + + ++
Sbjct: 1367 RRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPS 1426
Query: 535 KETK 538
K
Sbjct: 1427 DRVK 1430
Score = 94.3 bits (224), Expect = 2e-18
Identities = 64/257 (24%), Positives = 119/257 (46%), Gaps = 8/257 (3%)
Query: 887 RIRTVDGLNDKQD--WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSG 944
++ ++ + K+D W + G ++ D+ Y T IL+ I + G+ V L+G +G
Sbjct: 1171 KVMIIENSHVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRVGLLGRTG 1229
Query: 945 CGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIA 1004
GKST+L R + T G I++DGV S+TL + RK GV+ Q+ +F T +N+
Sbjct: 1230 SGKSTLLSAFLRLLN-TEGEIQIDGVS-WDSITLQQWRKAFGVIPQKVFIFSGTFRKNL- 1286
Query: 1005 YGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIR 1064
D + + E + I P + KQ +C+AR+++
Sbjct: 1287 --DPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLS 1344
Query: 1065 SPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIV 1124
++LLLDE ++ LD + + + L A T I HR+ + + V+++ K+
Sbjct: 1345 KAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVR 1404
Query: 1125 EKGNHAELIGLKGHYWQ 1141
+ + +L+ + + Q
Sbjct: 1405 QYDSIQKLLNERSLFRQ 1421
Score = 87.8 bits (208), Expect = 2e-16
Identities = 64/237 (27%), Positives = 115/237 (48%), Gaps = 22/237 (9%)
Query: 300 EDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLD 359
+ + FS S +LK + I+ G+ +A+ GS+G GK+++L ++ +P++G +K
Sbjct: 408 DSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHS 467
Query: 360 GRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYR---VAEMAYAHE 416
GR W+ GTI +NI G S D YR V + E
Sbjct: 468 GRISFCSQFSWIMP-------------GTIKENIIFG----VSYDEYRYRSVIKACQLEE 510
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-Q 475
I V+GE G +LSGGQ+ RI++AR++ ++ + LLD LD +EK++ +
Sbjct: 511 DISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFE 570
Query: 476 AALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAK-GFYHKLV 531
+ + + +T + V+ ++ + +I+ + +G+ GT EL + F KL+
Sbjct: 571 SCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 627
Score = 51.2 bits (117), Expect = 2e-05
Identities = 50/217 (23%), Positives = 90/217 (41%), Gaps = 22/217 (10%)
Query: 923 ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLR 982
+LK I+ +E G+ +A+ GS+G GK+++L +I +P+ G I+ G
Sbjct: 422 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSG------------- 468
Query: 983 KQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXX--XHNFIVSLPKGYETN 1040
++ Q + T+ ENI +G + DE I +
Sbjct: 469 -RISFCSQFSWIMPGTIKENIIFG-----VSYDEYRYRSVIKACQLEEDISKFAEKDNIV 522
Query: 1041 XXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEA-LDHAAKGRTC 1099
+ R+ +ARA+ + L LLD LD +E+ + E+ + +T
Sbjct: 523 LGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTR 582
Query: 1100 ITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLK 1136
I + ++ +K AD I +L +G G +EL L+
Sbjct: 583 ILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQ 619
Score = 35.1 bits (77), Expect = 1.5
Identities = 33/116 (28%), Positives = 52/116 (44%), Gaps = 6/116 (5%)
Query: 682 GAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGS 741
G + R S D A + L I +Q + +G I ++ V+T +P++V
Sbjct: 952 GGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGAIAVVAVLQPYIFVAT--VPVIVAF 1008
Query: 742 IWLEGIMSQKSQQDEREAMESATAIATEAVVSIK---TVQSLGIESLFITRFQDAL 794
I L Q SQQ ++ E + I T V S+K T+++ G + F T F AL
Sbjct: 1009 IMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKAL 1064
>DQ356260-1|ABC87059.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 122 bits (294), Expect = 7e-27
Identities = 63/244 (25%), Positives = 132/244 (54%), Gaps = 3/244 (1%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G+++++D+ Y + IL+ S I PG+ V L+G +G GKST+L RL + +G
Sbjct: 1208 GQMTVKDLTAKYTEGGNA-ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN-TEG 1265
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+++DG + ++ + R + GV+ Q+ +F GT N+ Y + + +++++VA+
Sbjct: 1266 EIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGL 1324
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
I+ P + V+ + G LS G KQ + +ARS+L + +LLLDE ++ LDP + + +
Sbjct: 1325 RSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQII 1384
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSG 534
+ L +A T + HR+ ++ C + + +++ + + + +L+ + + + ++
Sbjct: 1385 RRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPS 1444
Query: 535 KETK 538
K
Sbjct: 1445 DRVK 1448
Score = 94.3 bits (224), Expect = 2e-18
Identities = 64/257 (24%), Positives = 119/257 (46%), Gaps = 8/257 (3%)
Query: 887 RIRTVDGLNDKQD--WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSG 944
++ ++ + K+D W + G ++ D+ Y T IL+ I + G+ V L+G +G
Sbjct: 1189 KVMIIENSHVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRVGLLGRTG 1247
Query: 945 CGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIA 1004
GKST+L R + T G I++DGV S+TL + RK GV+ Q+ +F T +N+
Sbjct: 1248 SGKSTLLSAFLRLLN-TEGEIQIDGVS-WDSITLQQWRKAFGVIPQKVFIFSGTFRKNL- 1304
Query: 1005 YGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIR 1064
D + + E + I P + KQ +C+AR+++
Sbjct: 1305 --DPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLS 1362
Query: 1065 SPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIV 1124
++LLLDE ++ LD + + + L A T I HR+ + + V+++ K+
Sbjct: 1363 KAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVR 1422
Query: 1125 EKGNHAELIGLKGHYWQ 1141
+ + +L+ + + Q
Sbjct: 1423 QYDSIQKLLNERSLFRQ 1439
Score = 87.4 bits (207), Expect = 3e-16
Identities = 64/237 (27%), Positives = 115/237 (48%), Gaps = 22/237 (9%)
Query: 300 EDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLD 359
+ + FS S +LK + I+ G+ +A+ GS+G GK+++L ++ +P++G +K
Sbjct: 426 DSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHS 485
Query: 360 GRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYR---VAEMAYAHE 416
GR W+ GTI +NI G S D YR V + E
Sbjct: 486 GRISFCSQFSWIMP-------------GTIKENIIFG----VSYDEYRYRSVIKACQLEE 528
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-Q 475
I V+GE G +LSGGQ+ RI++AR++ ++ + LLD LD +EK++ +
Sbjct: 529 DISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFE 588
Query: 476 AALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAK-GFYHKLV 531
+ + + +T + V+ ++ + +I+ + +G+ GT EL + F KL+
Sbjct: 589 SCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 50.8 bits (116), Expect = 3e-05
Identities = 50/217 (23%), Positives = 90/217 (41%), Gaps = 22/217 (10%)
Query: 923 ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLR 982
+LK I+ +E G+ +A+ GS+G GK+++L +I +P+ G I+ G
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG------------- 486
Query: 983 KQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXX--XHNFIVSLPKGYETN 1040
++ Q + T+ ENI +G + DE I +
Sbjct: 487 -RISFCSQFSWIMPGTIKENIIFG-----VSYDEYRYRSVIKACQLEEDISKFAEKDNIV 540
Query: 1041 XXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEA-LDHAAKGRTC 1099
+ R+ +ARA+ + L LLD LD +E+ + E+ + +T
Sbjct: 541 LGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTR 600
Query: 1100 ITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLK 1136
I + ++ +K AD I +L +G G +EL L+
Sbjct: 601 ILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQ 637
Score = 35.1 bits (77), Expect = 1.5
Identities = 33/116 (28%), Positives = 52/116 (44%), Gaps = 6/116 (5%)
Query: 682 GAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGS 741
G + R S D A + L I +Q + +G I ++ V+T +P++V
Sbjct: 970 GGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGAIAVVAVLQPYIFVAT--VPVIVAF 1026
Query: 742 IWLEGIMSQKSQQDEREAMESATAIATEAVVSIK---TVQSLGIESLFITRFQDAL 794
I L Q SQQ ++ E + I T V S+K T+++ G + F T F AL
Sbjct: 1027 IMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKAL 1082
>DQ356259-1|ABC87057.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 122 bits (294), Expect = 7e-27
Identities = 63/244 (25%), Positives = 132/244 (54%), Gaps = 3/244 (1%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G+++++D+ Y + IL+ S I PG+ V L+G +G GKST+L RL + +G
Sbjct: 1208 GQMTVKDLTAKYTEGGNA-ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN-TEG 1265
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+++DG + ++ + R + GV+ Q+ +F GT N+ Y + + +++++VA+
Sbjct: 1266 EIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGL 1324
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
I+ P + V+ + G LS G KQ + +ARS+L + +LLLDE ++ LDP + + +
Sbjct: 1325 RSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQII 1384
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSG 534
+ L +A T + HR+ ++ C + + +++ + + + +L+ + + + ++
Sbjct: 1385 RRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPS 1444
Query: 535 KETK 538
K
Sbjct: 1445 DRVK 1448
Score = 94.3 bits (224), Expect = 2e-18
Identities = 64/257 (24%), Positives = 119/257 (46%), Gaps = 8/257 (3%)
Query: 887 RIRTVDGLNDKQD--WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSG 944
++ ++ + K+D W + G ++ D+ Y T IL+ I + G+ V L+G +G
Sbjct: 1189 KVMIIENSHVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRVGLLGRTG 1247
Query: 945 CGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIA 1004
GKST+L R + T G I++DGV S+TL + RK GV+ Q+ +F T +N+
Sbjct: 1248 SGKSTLLSAFLRLLN-TEGEIQIDGVS-WDSITLQQWRKAFGVIPQKVFIFSGTFRKNL- 1304
Query: 1005 YGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIR 1064
D + + E + I P + KQ +C+AR+++
Sbjct: 1305 --DPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLS 1362
Query: 1065 SPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIV 1124
++LLLDE ++ LD + + + L A T I HR+ + + V+++ K+
Sbjct: 1363 KAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVR 1422
Query: 1125 EKGNHAELIGLKGHYWQ 1141
+ + +L+ + + Q
Sbjct: 1423 QYDSIQKLLNERSLFRQ 1439
Score = 87.8 bits (208), Expect = 2e-16
Identities = 64/237 (27%), Positives = 115/237 (48%), Gaps = 22/237 (9%)
Query: 300 EDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLD 359
+ + FS S +LK + I+ G+ +A+ GS+G GK+++L ++ +P++G +K
Sbjct: 426 DSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHS 485
Query: 360 GRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYR---VAEMAYAHE 416
GR W+ GTI +NI G S D YR V + E
Sbjct: 486 GRISFCSQFSWIMP-------------GTIKENIIFG----VSYDEYRYRSVIKACQLEE 528
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-Q 475
I V+GE G +LSGGQ+ RI++AR++ ++ + LLD LD +EK++ +
Sbjct: 529 DISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFE 588
Query: 476 AALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAK-GFYHKLV 531
+ + + +T + V+ ++ + +I+ + +G+ GT EL + F KL+
Sbjct: 589 SCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 51.2 bits (117), Expect = 2e-05
Identities = 50/217 (23%), Positives = 90/217 (41%), Gaps = 22/217 (10%)
Query: 923 ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLR 982
+LK I+ +E G+ +A+ GS+G GK+++L +I +P+ G I+ G
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSG------------- 486
Query: 983 KQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXX--XHNFIVSLPKGYETN 1040
++ Q + T+ ENI +G + DE I +
Sbjct: 487 -RISFCSQFSWIMPGTIKENIIFG-----VSYDEYRYRSVIKACQLEEDISKFAEKDNIV 540
Query: 1041 XXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEA-LDHAAKGRTC 1099
+ R+ +ARA+ + L LLD LD +E+ + E+ + +T
Sbjct: 541 LGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTR 600
Query: 1100 ITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLK 1136
I + ++ +K AD I +L +G G +EL L+
Sbjct: 601 ILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQ 637
Score = 35.1 bits (77), Expect = 1.5
Identities = 33/116 (28%), Positives = 52/116 (44%), Gaps = 6/116 (5%)
Query: 682 GAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGS 741
G + R S D A + L I +Q + +G I ++ V+T +P++V
Sbjct: 970 GGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGAIAVVAVLQPYIFVAT--VPVIVAF 1026
Query: 742 IWLEGIMSQKSQQDEREAMESATAIATEAVVSIK---TVQSLGIESLFITRFQDAL 794
I L Q SQQ ++ E + I T V S+K T+++ G + F T F AL
Sbjct: 1027 IMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKAL 1082
>DQ356258-1|ABC87055.1| 1462|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1462
Score = 122 bits (294), Expect = 7e-27
Identities = 63/244 (25%), Positives = 132/244 (54%), Gaps = 3/244 (1%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G+++++D+ Y + IL+ S I PG+ V L+G +G GKST+L RL + +G
Sbjct: 1190 GQMTVKDLTAKYTEGGNA-ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN-TEG 1247
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+++DG + ++ + R + GV+ Q+ +F GT N+ Y + + +++++VA+
Sbjct: 1248 EIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGL 1306
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
I+ P + V+ + G LS G KQ + +ARS+L + +LLLDE ++ LDP + + +
Sbjct: 1307 RSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQII 1366
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSG 534
+ L +A T + HR+ ++ C + + +++ + + + +L+ + + + ++
Sbjct: 1367 RRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPS 1426
Query: 535 KETK 538
K
Sbjct: 1427 DRVK 1430
Score = 94.3 bits (224), Expect = 2e-18
Identities = 64/257 (24%), Positives = 119/257 (46%), Gaps = 8/257 (3%)
Query: 887 RIRTVDGLNDKQD--WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSG 944
++ ++ + K+D W + G ++ D+ Y T IL+ I + G+ V L+G +G
Sbjct: 1171 KVMIIENSHVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRVGLLGRTG 1229
Query: 945 CGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIA 1004
GKST+L R + T G I++DGV S+TL + RK GV+ Q+ +F T +N+
Sbjct: 1230 SGKSTLLSAFLRLLN-TEGEIQIDGVS-WDSITLQQWRKAFGVIPQKVFIFSGTFRKNL- 1286
Query: 1005 YGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIR 1064
D + + E + I P + KQ +C+AR+++
Sbjct: 1287 --DPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLS 1344
Query: 1065 SPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIV 1124
++LLLDE ++ LD + + + L A T I HR+ + + V+++ K+
Sbjct: 1345 KAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVR 1404
Query: 1125 EKGNHAELIGLKGHYWQ 1141
+ + +L+ + + Q
Sbjct: 1405 QYDSIQKLLNERSLFRQ 1421
Score = 87.8 bits (208), Expect = 2e-16
Identities = 64/237 (27%), Positives = 115/237 (48%), Gaps = 22/237 (9%)
Query: 300 EDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLD 359
+ + FS S +LK + I+ G+ +A+ GS+G GK+++L ++ +P++G +K
Sbjct: 408 DSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHS 467
Query: 360 GRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYR---VAEMAYAHE 416
GR W+ GTI +NI G S D YR V + E
Sbjct: 468 GRISFCSQFSWIMP-------------GTIKENIIFG----VSYDEYRYRSVIKACQLEE 510
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-Q 475
I V+GE G +LSGGQ+ RI++AR++ ++ + LLD LD +EK++ +
Sbjct: 511 DISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFE 570
Query: 476 AALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAK-GFYHKLV 531
+ + + +T + V+ ++ + +I+ + +G+ GT EL + F KL+
Sbjct: 571 SCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 627
Score = 51.2 bits (117), Expect = 2e-05
Identities = 50/217 (23%), Positives = 90/217 (41%), Gaps = 22/217 (10%)
Query: 923 ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLR 982
+LK I+ +E G+ +A+ GS+G GK+++L +I +P+ G I+ G
Sbjct: 422 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSG------------- 468
Query: 983 KQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXX--XHNFIVSLPKGYETN 1040
++ Q + T+ ENI +G + DE I +
Sbjct: 469 -RISFCSQFSWIMPGTIKENIIFG-----VSYDEYRYRSVIKACQLEEDISKFAEKDNIV 522
Query: 1041 XXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEA-LDHAAKGRTC 1099
+ R+ +ARA+ + L LLD LD +E+ + E+ + +T
Sbjct: 523 LGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTR 582
Query: 1100 ITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLK 1136
I + ++ +K AD I +L +G G +EL L+
Sbjct: 583 ILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQ 619
Score = 35.1 bits (77), Expect = 1.5
Identities = 33/116 (28%), Positives = 52/116 (44%), Gaps = 6/116 (5%)
Query: 682 GAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGS 741
G + R S D A + L I +Q + +G I ++ V+T +P++V
Sbjct: 952 GGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGAIAVVAVLQPYIFVAT--VPVIVAF 1008
Query: 742 IWLEGIMSQKSQQDEREAMESATAIATEAVVSIK---TVQSLGIESLFITRFQDAL 794
I L Q SQQ ++ E + I T V S+K T+++ G + F T F AL
Sbjct: 1009 IMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKAL 1064
>DQ356257-1|ABC87053.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 122 bits (294), Expect = 7e-27
Identities = 63/244 (25%), Positives = 132/244 (54%), Gaps = 3/244 (1%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G+++++D+ Y + IL+ S I PG+ V L+G +G GKST+L RL + +G
Sbjct: 1208 GQMTVKDLTAKYTEGGNA-ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN-TEG 1265
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+++DG + ++ + R + GV+ Q+ +F GT N+ Y + + +++++VA+
Sbjct: 1266 EIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGL 1324
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
I+ P + V+ + G LS G KQ + +ARS+L + +LLLDE ++ LDP + + +
Sbjct: 1325 RSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQII 1384
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSG 534
+ L +A T + HR+ ++ C + + +++ + + + +L+ + + + ++
Sbjct: 1385 RRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPS 1444
Query: 535 KETK 538
K
Sbjct: 1445 DRVK 1448
Score = 94.3 bits (224), Expect = 2e-18
Identities = 64/257 (24%), Positives = 119/257 (46%), Gaps = 8/257 (3%)
Query: 887 RIRTVDGLNDKQD--WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSG 944
++ ++ + K+D W + G ++ D+ Y T IL+ I + G+ V L+G +G
Sbjct: 1189 KVMIIENSHVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRVGLLGRTG 1247
Query: 945 CGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIA 1004
GKST+L R + T G I++DGV S+TL + RK GV+ Q+ +F T +N+
Sbjct: 1248 SGKSTLLSAFLRLLN-TEGEIQIDGVS-WDSITLQQWRKAFGVIPQKVFIFSGTFRKNL- 1304
Query: 1005 YGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIR 1064
D + + E + I P + KQ +C+AR+++
Sbjct: 1305 --DPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLS 1362
Query: 1065 SPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIV 1124
++LLLDE ++ LD + + + L A T I HR+ + + V+++ K+
Sbjct: 1363 KAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVR 1422
Query: 1125 EKGNHAELIGLKGHYWQ 1141
+ + +L+ + + Q
Sbjct: 1423 QYDSIQKLLNERSLFRQ 1439
Score = 52.0 bits (119), Expect = 1e-05
Identities = 50/237 (21%), Positives = 96/237 (40%), Gaps = 22/237 (9%)
Query: 300 EDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLD 359
+ + FS S +LK + I+ G+ +A+ GS+G GK+++L ++ +P++G +K
Sbjct: 426 DSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHS 485
Query: 360 GRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYR---VAEMAYAHE 416
GR W + GTI +NI G S D YR V + E
Sbjct: 486 GRISFCSQFSW-------------IMPGTIKENIIFG----VSYDEYRYRSVIKACQLEE 528
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-Q 475
++ ++ + LLD LD +EK++ +
Sbjct: 529 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXAVYKDADLYLLDSPFGYLDVLTEKEIFE 588
Query: 476 AALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAK-GFYHKLV 531
+ + + +T + V+ ++ + +I+ + +G+ GT EL + F KL+
Sbjct: 589 SCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 41.1 bits (92), Expect = 0.022
Identities = 17/47 (36%), Positives = 31/47 (65%)
Query: 923 ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDG 969
+LK I+ +E G+ +A+ GS+G GK+++L +I +P+ G I+ G
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSG 486
Score = 35.1 bits (77), Expect = 1.5
Identities = 33/116 (28%), Positives = 52/116 (44%), Gaps = 6/116 (5%)
Query: 682 GAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGS 741
G + R S D A + L I +Q + +G I ++ V+T +P++V
Sbjct: 970 GGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGAIAVVAVLQPYIFVAT--VPVIVAF 1026
Query: 742 IWLEGIMSQKSQQDEREAMESATAIATEAVVSIK---TVQSLGIESLFITRFQDAL 794
I L Q SQQ ++ E + I T V S+K T+++ G + F T F AL
Sbjct: 1027 IMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKAL 1082
>DQ354391-1|ABC79056.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 122 bits (294), Expect = 7e-27
Identities = 63/244 (25%), Positives = 132/244 (54%), Gaps = 3/244 (1%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G+++++D+ Y + IL+ S I PG+ V L+G +G GKST+L RL + +G
Sbjct: 1208 GQMTVKDLTAKYTEGGNA-ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN-TEG 1265
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+++DG + ++ + R + GV+ Q+ +F GT N+ Y + + +++++VA+
Sbjct: 1266 EIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGL 1324
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
I+ P + V+ + G LS G KQ + +ARS+L + +LLLDE ++ LDP + + +
Sbjct: 1325 RSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQII 1384
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSG 534
+ L +A T + HR+ ++ C + + +++ + + + +L+ + + + ++
Sbjct: 1385 RRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPS 1444
Query: 535 KETK 538
K
Sbjct: 1445 DRVK 1448
Score = 94.3 bits (224), Expect = 2e-18
Identities = 64/257 (24%), Positives = 119/257 (46%), Gaps = 8/257 (3%)
Query: 887 RIRTVDGLNDKQD--WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSG 944
++ ++ + K+D W + G ++ D+ Y T IL+ I + G+ V L+G +G
Sbjct: 1189 KVMIIENSHVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRVGLLGRTG 1247
Query: 945 CGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIA 1004
GKST+L R + T G I++DGV S+TL + RK GV+ Q+ +F T +N+
Sbjct: 1248 SGKSTLLSAFLRLLN-TEGEIQIDGVS-WDSITLQQWRKAFGVIPQKVFIFSGTFRKNL- 1304
Query: 1005 YGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIR 1064
D + + E + I P + KQ +C+AR+++
Sbjct: 1305 --DPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLS 1362
Query: 1065 SPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIV 1124
++LLLDE ++ LD + + + L A T I HR+ + + V+++ K+
Sbjct: 1363 KAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVR 1422
Query: 1125 EKGNHAELIGLKGHYWQ 1141
+ + +L+ + + Q
Sbjct: 1423 QYDSIQKLLNERSLFRQ 1439
Score = 87.8 bits (208), Expect = 2e-16
Identities = 64/237 (27%), Positives = 115/237 (48%), Gaps = 22/237 (9%)
Query: 300 EDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLD 359
+ + FS S +LK + I+ G+ +A+ GS+G GK+++L ++ +P++G +K
Sbjct: 426 DSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHS 485
Query: 360 GRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYR---VAEMAYAHE 416
GR W+ GTI +NI G S D YR V + E
Sbjct: 486 GRISFCSQFSWIMP-------------GTIKENIIFG----VSYDEYRYRSVIKACQLEE 528
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-Q 475
I V+GE G +LSGGQ+ RI++AR++ ++ + LLD LD +EK++ +
Sbjct: 529 DISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFE 588
Query: 476 AALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAK-GFYHKLV 531
+ + + +T + V+ ++ + +I+ + +G+ GT EL + F KL+
Sbjct: 589 SCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 51.2 bits (117), Expect = 2e-05
Identities = 50/217 (23%), Positives = 90/217 (41%), Gaps = 22/217 (10%)
Query: 923 ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLR 982
+LK I+ +E G+ +A+ GS+G GK+++L +I +P+ G I+ G
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSG------------- 486
Query: 983 KQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXX--XHNFIVSLPKGYETN 1040
++ Q + T+ ENI +G + DE I +
Sbjct: 487 -RISFCSQFSWIMPGTIKENIIFG-----VSYDEYRYRSVIKACQLEEDISKFAEKDNIV 540
Query: 1041 XXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEA-LDHAAKGRTC 1099
+ R+ +ARA+ + L LLD LD +E+ + E+ + +T
Sbjct: 541 LGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTR 600
Query: 1100 ITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLK 1136
I + ++ +K AD I +L +G G +EL L+
Sbjct: 601 ILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQ 637
Score = 35.1 bits (77), Expect = 1.5
Identities = 33/116 (28%), Positives = 52/116 (44%), Gaps = 6/116 (5%)
Query: 682 GAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGS 741
G + R S D A + L I +Q + +G I ++ V+T +P++V
Sbjct: 970 GGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGAIAVVAVLQPYIFVAT--VPVIVAF 1026
Query: 742 IWLEGIMSQKSQQDEREAMESATAIATEAVVSIK---TVQSLGIESLFITRFQDAL 794
I L Q SQQ ++ E + I T V S+K T+++ G + F T F AL
Sbjct: 1027 IMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKAL 1082
>DQ354390-1|ABC79054.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 122 bits (294), Expect = 7e-27
Identities = 63/244 (25%), Positives = 132/244 (54%), Gaps = 3/244 (1%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G+++++D+ Y + IL+ S I PG+ V L+G +G GKST+L RL + +G
Sbjct: 1208 GQMTVKDLTAKYTEGGNA-ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN-TEG 1265
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+++DG + ++ + R + GV+ Q+ +F GT N+ Y + + +++++VA+
Sbjct: 1266 EIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGL 1324
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
I+ P + V+ + G LS G KQ + +ARS+L + +LLLDE ++ LDP + + +
Sbjct: 1325 RSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQII 1384
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSG 534
+ L +A T + HR+ ++ C + + +++ + + + +L+ + + + ++
Sbjct: 1385 RRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPS 1444
Query: 535 KETK 538
K
Sbjct: 1445 DRVK 1448
Score = 94.3 bits (224), Expect = 2e-18
Identities = 64/257 (24%), Positives = 119/257 (46%), Gaps = 8/257 (3%)
Query: 887 RIRTVDGLNDKQD--WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSG 944
++ ++ + K+D W + G ++ D+ Y T IL+ I + G+ V L+G +G
Sbjct: 1189 KVMIIENSHVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRVGLLGRTG 1247
Query: 945 CGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIA 1004
GKST+L R + T G I++DGV S+TL + RK GV+ Q+ +F T +N+
Sbjct: 1248 SGKSTLLSAFLRLLN-TEGEIQIDGVS-WDSITLQQWRKAFGVIPQKVFIFSGTFRKNL- 1304
Query: 1005 YGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIR 1064
D + + E + I P + KQ +C+AR+++
Sbjct: 1305 --DPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLS 1362
Query: 1065 SPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIV 1124
++LLLDE ++ LD + + + L A T I HR+ + + V+++ K+
Sbjct: 1363 KAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVR 1422
Query: 1125 EKGNHAELIGLKGHYWQ 1141
+ + +L+ + + Q
Sbjct: 1423 QYDSIQKLLNERSLFRQ 1439
Score = 87.8 bits (208), Expect = 2e-16
Identities = 64/237 (27%), Positives = 115/237 (48%), Gaps = 22/237 (9%)
Query: 300 EDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLD 359
+ + FS S +LK + I+ G+ +A+ GS+G GK+++L ++ +P++G +K
Sbjct: 426 DSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHS 485
Query: 360 GRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYR---VAEMAYAHE 416
GR W+ GTI +NI G S D YR V + E
Sbjct: 486 GRISFCSQFSWIMP-------------GTIKENIIFG----VSYDEYRYRSVIKACQLEE 528
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-Q 475
I V+GE G +LSGGQ+ RI++AR++ ++ + LLD LD +EK++ +
Sbjct: 529 DISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFE 588
Query: 476 AALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAK-GFYHKLV 531
+ + + +T + V+ ++ + +I+ + +G+ GT EL + F KL+
Sbjct: 589 SCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 51.2 bits (117), Expect = 2e-05
Identities = 50/217 (23%), Positives = 90/217 (41%), Gaps = 22/217 (10%)
Query: 923 ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLR 982
+LK I+ +E G+ +A+ GS+G GK+++L +I +P+ G I+ G
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSG------------- 486
Query: 983 KQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXX--XHNFIVSLPKGYETN 1040
++ Q + T+ ENI +G + DE I +
Sbjct: 487 -RISFCSQFSWIMPGTIKENIIFG-----VSYDEYRYRSVIKACQLEEDISKFAEKDNIV 540
Query: 1041 XXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEA-LDHAAKGRTC 1099
+ R+ +ARA+ + L LLD LD +E+ + E+ + +T
Sbjct: 541 LGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTR 600
Query: 1100 ITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLK 1136
I + ++ +K AD I +L +G G +EL L+
Sbjct: 601 ILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQ 637
Score = 35.1 bits (77), Expect = 1.5
Identities = 33/116 (28%), Positives = 52/116 (44%), Gaps = 6/116 (5%)
Query: 682 GAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGS 741
G + R S D A + L I +Q + +G I ++ V+T +P++V
Sbjct: 970 GGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGAIAVVAVLQPYIFVAT--VPVIVAF 1026
Query: 742 IWLEGIMSQKSQQDEREAMESATAIATEAVVSIK---TVQSLGIESLFITRFQDAL 794
I L Q SQQ ++ E + I T V S+K T+++ G + F T F AL
Sbjct: 1027 IMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKAL 1082
>DQ354389-1|ABC79052.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 122 bits (294), Expect = 7e-27
Identities = 63/244 (25%), Positives = 132/244 (54%), Gaps = 3/244 (1%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G+++++D+ Y + IL+ S I PG+ V L+G +G GKST+L RL + +G
Sbjct: 1208 GQMTVKDLTAKYTEGGNA-ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN-TEG 1265
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+++DG + ++ + R + GV+ Q+ +F GT N+ Y + + +++++VA+
Sbjct: 1266 EIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGL 1324
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
I+ P + V+ + G LS G KQ + +ARS+L + +LLLDE ++ LDP + + +
Sbjct: 1325 RSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQII 1384
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSG 534
+ L +A T + HR+ ++ C + + +++ + + + +L+ + + + ++
Sbjct: 1385 RRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPS 1444
Query: 535 KETK 538
K
Sbjct: 1445 DRVK 1448
Score = 94.3 bits (224), Expect = 2e-18
Identities = 64/257 (24%), Positives = 119/257 (46%), Gaps = 8/257 (3%)
Query: 887 RIRTVDGLNDKQD--WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSG 944
++ ++ + K+D W + G ++ D+ Y T IL+ I + G+ V L+G +G
Sbjct: 1189 KVMIIENSHVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRVGLLGRTG 1247
Query: 945 CGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIA 1004
GKST+L R + T G I++DGV S+TL + RK GV+ Q+ +F T +N+
Sbjct: 1248 SGKSTLLSAFLRLLN-TEGEIQIDGVS-WDSITLQQWRKAFGVIPQKVFIFSGTFRKNL- 1304
Query: 1005 YGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIR 1064
D + + E + I P + KQ +C+AR+++
Sbjct: 1305 --DPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLS 1362
Query: 1065 SPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIV 1124
++LLLDE ++ LD + + + L A T I HR+ + + V+++ K+
Sbjct: 1363 KAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVR 1422
Query: 1125 EKGNHAELIGLKGHYWQ 1141
+ + +L+ + + Q
Sbjct: 1423 QYDSIQKLLNERSLFRQ 1439
Score = 87.8 bits (208), Expect = 2e-16
Identities = 64/237 (27%), Positives = 115/237 (48%), Gaps = 22/237 (9%)
Query: 300 EDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLD 359
+ + FS S +LK + I+ G+ +A+ GS+G GK+++L ++ +P++G +K
Sbjct: 426 DSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHS 485
Query: 360 GRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYR---VAEMAYAHE 416
GR W+ GTI +NI G S D YR V + E
Sbjct: 486 GRISFCSQFSWIMP-------------GTIKENIIFG----VSYDEYRYRSVIKACQLEE 528
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-Q 475
I V+GE G +LSGGQ+ RI++AR++ ++ + LLD LD +EK++ +
Sbjct: 529 DISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFE 588
Query: 476 AALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAK-GFYHKLV 531
+ + + +T + V+ ++ + +I+ + +G+ GT EL + F KL+
Sbjct: 589 SCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 51.2 bits (117), Expect = 2e-05
Identities = 50/217 (23%), Positives = 90/217 (41%), Gaps = 22/217 (10%)
Query: 923 ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLR 982
+LK I+ +E G+ +A+ GS+G GK+++L +I +P+ G I+ G
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSG------------- 486
Query: 983 KQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXX--XHNFIVSLPKGYETN 1040
++ Q + T+ ENI +G + DE I +
Sbjct: 487 -RISFCSQFSWIMPGTIKENIIFG-----VSYDEYRYRSVIKACQLEEDISKFAEKDNIV 540
Query: 1041 XXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEA-LDHAAKGRTC 1099
+ R+ +ARA+ + L LLD LD +E+ + E+ + +T
Sbjct: 541 LGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTR 600
Query: 1100 ITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLK 1136
I + ++ +K AD I +L +G G +EL L+
Sbjct: 601 ILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQ 637
Score = 35.1 bits (77), Expect = 1.5
Identities = 33/116 (28%), Positives = 52/116 (44%), Gaps = 6/116 (5%)
Query: 682 GAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGS 741
G + R S D A + L I +Q + +G I ++ V+T +P++V
Sbjct: 970 GGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGAIAVVAVLQPYIFVAT--VPVIVAF 1026
Query: 742 IWLEGIMSQKSQQDEREAMESATAIATEAVVSIK---TVQSLGIESLFITRFQDAL 794
I L Q SQQ ++ E + I T V S+K T+++ G + F T F AL
Sbjct: 1027 IMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKAL 1082
>DQ354388-1|ABC79050.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 122 bits (294), Expect = 7e-27
Identities = 63/244 (25%), Positives = 132/244 (54%), Gaps = 3/244 (1%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G+++++D+ Y + IL+ S I PG+ V L+G +G GKST+L RL + +G
Sbjct: 1208 GQMTVKDLTAKYTEGGNA-ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN-TEG 1265
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+++DG + ++ + R + GV+ Q+ +F GT N+ Y + + +++++VA+
Sbjct: 1266 EIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGL 1324
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
I+ P + V+ + G LS G KQ + +ARS+L + +LLLDE ++ LDP + + +
Sbjct: 1325 RSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQII 1384
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSG 534
+ L +A T + HR+ ++ C + + +++ + + + +L+ + + + ++
Sbjct: 1385 RRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPS 1444
Query: 535 KETK 538
K
Sbjct: 1445 DRVK 1448
Score = 94.3 bits (224), Expect = 2e-18
Identities = 64/257 (24%), Positives = 119/257 (46%), Gaps = 8/257 (3%)
Query: 887 RIRTVDGLNDKQD--WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSG 944
++ ++ + K+D W + G ++ D+ Y T IL+ I + G+ V L+G +G
Sbjct: 1189 KVMIIENSHVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRVGLLGRTG 1247
Query: 945 CGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIA 1004
GKST+L R + T G I++DGV S+TL + RK GV+ Q+ +F T +N+
Sbjct: 1248 SGKSTLLSAFLRLLN-TEGEIQIDGVS-WDSITLQQWRKAFGVIPQKVFIFSGTFRKNL- 1304
Query: 1005 YGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIR 1064
D + + E + I P + KQ +C+AR+++
Sbjct: 1305 --DPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLS 1362
Query: 1065 SPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIV 1124
++LLLDE ++ LD + + + L A T I HR+ + + V+++ K+
Sbjct: 1363 KAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVR 1422
Query: 1125 EKGNHAELIGLKGHYWQ 1141
+ + +L+ + + Q
Sbjct: 1423 QYDSIQKLLNERSLFRQ 1439
Score = 87.8 bits (208), Expect = 2e-16
Identities = 64/237 (27%), Positives = 115/237 (48%), Gaps = 22/237 (9%)
Query: 300 EDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLD 359
+ + FS S +LK + I+ G+ +A+ GS+G GK+++L ++ +P++G +K
Sbjct: 426 DSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHS 485
Query: 360 GRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYR---VAEMAYAHE 416
GR W+ GTI +NI G S D YR V + E
Sbjct: 486 GRISFCSQFSWIMP-------------GTIKENIIFG----VSYDEYRYRSVIKACQLEE 528
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-Q 475
I V+GE G +LSGGQ+ RI++AR++ ++ + LLD LD +EK++ +
Sbjct: 529 DISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFE 588
Query: 476 AALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAK-GFYHKLV 531
+ + + +T + V+ ++ + +I+ + +G+ GT EL + F KL+
Sbjct: 589 SCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 51.2 bits (117), Expect = 2e-05
Identities = 50/217 (23%), Positives = 90/217 (41%), Gaps = 22/217 (10%)
Query: 923 ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLR 982
+LK I+ +E G+ +A+ GS+G GK+++L +I +P+ G I+ G
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSG------------- 486
Query: 983 KQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXX--XHNFIVSLPKGYETN 1040
++ Q + T+ ENI +G + DE I +
Sbjct: 487 -RISFCSQFSWIMPGTIKENIIFG-----VSYDEYRYRSVIKACQLEEDISKFAEKDNIV 540
Query: 1041 XXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEA-LDHAAKGRTC 1099
+ R+ +ARA+ + L LLD LD +E+ + E+ + +T
Sbjct: 541 LGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTR 600
Query: 1100 ITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLK 1136
I + ++ +K AD I +L +G G +EL L+
Sbjct: 601 ILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQ 637
Score = 35.1 bits (77), Expect = 1.5
Identities = 33/116 (28%), Positives = 52/116 (44%), Gaps = 6/116 (5%)
Query: 682 GAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGS 741
G + R S D A + L I +Q + +G I ++ V+T +P++V
Sbjct: 970 GGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGAIAVVAVLQPYIFVAT--VPVIVAF 1026
Query: 742 IWLEGIMSQKSQQDEREAMESATAIATEAVVSIK---TVQSLGIESLFITRFQDAL 794
I L Q SQQ ++ E + I T V S+K T+++ G + F T F AL
Sbjct: 1027 IMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKAL 1082
>AC000061-1|AAB46340.2| 484|Homo sapiens unknown protein.
Length = 484
Score = 122 bits (294), Expect = 7e-27
Identities = 63/244 (25%), Positives = 132/244 (54%), Gaps = 3/244 (1%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G+++++D+ Y + IL+ S I PG+ V L+G +G GKST+L RL + +G
Sbjct: 212 GQMTVKDLTAKYTEGGNA-ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN-TEG 269
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+++DG + ++ + R + GV+ Q+ +F GT N+ Y + + +++++VA+
Sbjct: 270 EIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGL 328
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
I+ P + V+ + G LS G KQ + +ARS+L + +LLLDE ++ LDP + + +
Sbjct: 329 RSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQII 388
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSG 534
+ L +A T + HR+ ++ C + + +++ + + + +L+ + + + ++
Sbjct: 389 RRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPS 448
Query: 535 KETK 538
K
Sbjct: 449 DRVK 452
Score = 94.3 bits (224), Expect = 2e-18
Identities = 64/257 (24%), Positives = 119/257 (46%), Gaps = 8/257 (3%)
Query: 887 RIRTVDGLNDKQD--WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSG 944
++ ++ + K+D W + G ++ D+ Y T IL+ I + G+ V L+G +G
Sbjct: 193 KVMIIENSHVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRVGLLGRTG 251
Query: 945 CGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIA 1004
GKST+L R + T G I++DGV S+TL + RK GV+ Q+ +F T +N+
Sbjct: 252 SGKSTLLSAFLRLLN-TEGEIQIDGVS-WDSITLQQWRKAFGVIPQKVFIFSGTFRKNL- 308
Query: 1005 YGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIR 1064
D + + E + I P + KQ +C+AR+++
Sbjct: 309 --DPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLS 366
Query: 1065 SPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIV 1124
++LLLDE ++ LD + + + L A T I HR+ + + V+++ K+
Sbjct: 367 KAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVR 426
Query: 1125 EKGNHAELIGLKGHYWQ 1141
+ + +L+ + + Q
Sbjct: 427 QYDSIQKLLNERSLFRQ 443
>L09191-1|AAA58648.1| 129|Homo sapiens TAP2 protein.
Length = 129
Score = 119 bits (286), Expect = 7e-26
Identities = 59/127 (46%), Positives = 83/127 (65%)
Query: 346 QRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDV 405
Q LY P G V LD + + +L S + VGQEPVLF G++ +NIA G + V
Sbjct: 1 QNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKV 60
Query: 406 YRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSA 465
A+ A+A +FI+ + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDEATSA
Sbjct: 61 MAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSA 120
Query: 466 LDPHSEK 472
LD E+
Sbjct: 121 LDVQCEQ 127
Score = 81.4 bits (192), Expect = 2e-14
Identities = 50/132 (37%), Positives = 68/132 (51%), Gaps = 3/132 (2%)
Query: 955 QRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTM 1014
Q Y PT G + LD I++ L Q+ V QEP+LF ++ NIAYG S +
Sbjct: 1 QNLYQPTGGQVLLDEKPISQYEHCY-LHSQVVSVGQEPVLFSGSVRNNIAYGLQSCED-- 57
Query: 1015 DEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEA 1074
D+ +FI + G T+ KQR+ IARAL+R PR+L+LDEA
Sbjct: 58 DKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEA 117
Query: 1075 TSALDANSERAV 1086
TSALD E+A+
Sbjct: 118 TSALDVQCEQAL 129
>AB209103-1|BAD92340.1| 799|Homo sapiens ATP-binding cassette C5
splicing variant A variant protein.
Length = 799
Score = 118 bits (283), Expect = 2e-25
Identities = 84/283 (29%), Positives = 139/283 (49%), Gaps = 22/283 (7%)
Query: 313 KILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLR 372
+ L L I+ G+ V + GS G GK++++ + +GS+ + G
Sbjct: 474 RTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISG------------ 521
Query: 373 SSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGER 432
+ V Q+ + T+ DNI G E E V + LP+ T IGER
Sbjct: 522 -TFAYVAQQAWILNATLRDNILFG-KEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGER 579
Query: 433 GASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-QAALDRASVGRTTLTVS 491
GA+LSGGQ+QRI++AR+L + ++ +LD+ SALD H + +A+ + +T L V+
Sbjct: 580 GANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVT 639
Query: 492 HRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTS--GKETKEPEEIGTVLE- 548
H+L +V+C +I M +G I E+GTH ELM G Y + + ET P EI + E
Sbjct: 640 HQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLLGET-PPVEINSKKET 698
Query: 549 ---EQETKQNGELQPAVRPEPDVKRRSVRKLHRRQSAKGAHEW 588
+++++ G +V+ E VK + + + +G+ W
Sbjct: 699 SGSQKKSQDKGPKTGSVKKEKAVKPEEGQLVQLEEKGQGSVPW 741
Score = 77.4 bits (182), Expect = 3e-13
Identities = 57/220 (25%), Positives = 93/220 (42%), Gaps = 18/220 (8%)
Query: 921 QMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNR 980
Q L IDL ++ GK V + GS G GK++++ I G+I + G
Sbjct: 473 QRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGT---------- 522
Query: 981 LRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETN 1040
V Q+ + + TL +NI +G ++ + + LP T
Sbjct: 523 ----FAYVAQQAWILNATLRDNILFG---KEYDEERYNSVLNSCCLRPDLAILPSSDLTE 575
Query: 1041 XXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDAN-SERAVTEALDHAAKGRTC 1099
+QR+ +ARAL + +LD+ SALDA+ A+ K +T
Sbjct: 576 IGERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTV 635
Query: 1100 ITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHY 1139
+ + H+L + D D + + +G I E+G H EL+ L G Y
Sbjct: 636 LFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDY 675
>L10287-1|AAA58649.1| 129|Homo sapiens TAP2 protein.
Length = 129
Score = 117 bits (282), Expect = 2e-25
Identities = 58/127 (45%), Positives = 82/127 (64%)
Query: 346 QRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDV 405
Q LY P G V LD + + +L S + VGQEPVLF G++ +NI G + V
Sbjct: 1 QNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNITYGLQSCEDDKV 60
Query: 406 YRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSA 465
A+ A+A +FI+ + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDEATSA
Sbjct: 61 MAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSA 120
Query: 466 LDPHSEK 472
LD E+
Sbjct: 121 LDVQCEQ 127
Score = 79.8 bits (188), Expect = 5e-14
Identities = 49/132 (37%), Positives = 67/132 (50%), Gaps = 3/132 (2%)
Query: 955 QRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTM 1014
Q Y PT G + LD I++ L Q+ V QEP+LF ++ NI YG S +
Sbjct: 1 QNLYQPTGGQVLLDEKPISQYEHCY-LHSQVVSVGQEPVLFSGSVRNNITYGLQSCED-- 57
Query: 1015 DEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEA 1074
D+ +FI + G T+ KQR+ IARAL+R PR+L+LDEA
Sbjct: 58 DKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEA 117
Query: 1075 TSALDANSERAV 1086
TSALD E+A+
Sbjct: 118 TSALDVQCEQAL 129
>AY848829-1|AAW33656.1| 258|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
subfam protein.
Length = 258
Score = 115 bits (277), Expect = 9e-25
Identities = 61/210 (29%), Positives = 117/210 (55%), Gaps = 3/210 (1%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G+++++D+ Y + IL+ S I PG+ V L+G +G GKST+L RL + +G
Sbjct: 52 GQMTVKDLTAKYTEGGNA-ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN-TEG 109
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYA 414
+++DG + ++ + R + GV+ Q+ +F GT N+ Y + + +++++VA+
Sbjct: 110 EIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGL 168
Query: 415 HEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV 474
I+ P + V+ + G LS G KQ + +ARS+L + +LLLDE ++ LDP + + +
Sbjct: 169 RSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQII 228
Query: 475 QAALDRASVGRTTLTVSHRLSTIVNCHRII 504
+ L +A T + HR+ ++ C + +
Sbjct: 229 RRTLKQAFADCTVILCEHRIEAMLECQQFL 258
Score = 88.6 bits (210), Expect = 1e-16
Identities = 60/222 (27%), Positives = 103/222 (46%), Gaps = 8/222 (3%)
Query: 887 RIRTVDGLNDKQD--WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSG 944
++ ++ + K+D W + G ++ D+ Y T IL+ I + G+ V L+G +G
Sbjct: 33 KVMIIENSHVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRVGLLGRTG 91
Query: 945 CGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIA 1004
GKST+L R + T G I++DGV S+TL + RK GV+ Q+ +F T +N+
Sbjct: 92 SGKSTLLSAFLRLLN-TEGEIQIDGVS-WDSITLQQWRKAFGVIPQKVFIFSGTFRKNL- 148
Query: 1005 YGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIR 1064
D + + E + I P + KQ +C+AR+++
Sbjct: 149 --DPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLS 206
Query: 1065 SPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRL 1106
++LLLDE ++ LD + + + L A T I HR+
Sbjct: 207 KAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRI 248
>AB208973-1|BAD92210.1| 776|Homo sapiens ABCC4 protein variant
protein.
Length = 776
Score = 114 bits (274), Expect = 2e-24
Identities = 75/275 (27%), Positives = 137/275 (49%), Gaps = 16/275 (5%)
Query: 297 ISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSV 356
+ ++D + S+ L+G S ++PGE +A+VG G GKS++L + P+ G V
Sbjct: 327 VHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLV 386
Query: 357 KLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHE 416
+ GR + V Q+P +F GT+ NI G E E +V + +
Sbjct: 387 SVHGR-------------IAYVSQQPWVFSGTLRSNILFG-KEYEKERYEKVIKACALKK 432
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-Q 475
++ L +G TVIG+RG +LSGGQK R+ +AR++ ++ + LLD+ SA+D + + +
Sbjct: 433 DLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFE 492
Query: 476 AALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAK-GFYHKLVTSG 534
+ + + T+ V+H+L + +I+ + G ++++GT+ E +K+ F L
Sbjct: 493 LCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDN 552
Query: 535 KETKEPEEIGTVLEEQETKQNGELQPAVRPEPDVK 569
+E+++P GT T + P +K
Sbjct: 553 EESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLK 587
Score = 72.1 bits (169), Expect = 1e-11
Identities = 59/225 (26%), Positives = 97/225 (43%), Gaps = 18/225 (8%)
Query: 924 LKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRK 983
L+G+ V G+ +A+VG G GKS++L + P+ G + + G
Sbjct: 345 LQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHG-------------- 390
Query: 984 QLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXX 1043
++ V Q+P +F TL NI +G K ++ + L G T
Sbjct: 391 RIAYVSQQPWVFSGTLRSNILFGKEYEKERYEKVIKACALKKD---LQLLEDGDLTVIGD 447
Query: 1044 XXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTE-ALDHAAKGRTCITI 1102
K RV +ARA+ + + LLD+ SA+DA R + E + + I +
Sbjct: 448 RGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILV 507
Query: 1103 AHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSKQQN 1147
H+L +K A I +L GK+V+KG + E + + L K+ N
Sbjct: 508 THQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDN 552
>BC041560-1|AAH41560.1| 859|Homo sapiens ABCC4 protein protein.
Length = 859
Score = 112 bits (270), Expect = 6e-24
Identities = 74/275 (26%), Positives = 137/275 (49%), Gaps = 16/275 (5%)
Query: 297 ISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSV 356
+ ++D + S+ L+G S ++PGE +A+VG G GKS++L + P+ G V
Sbjct: 410 VHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLV 469
Query: 357 KLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHE 416
+ GR + V Q+P +F GT+ NI G + E +V + +
Sbjct: 470 SVHGR-------------IAYVSQQPWVFSGTLRSNILFG-KKYEKERYEKVIKACALKK 515
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-Q 475
++ L +G TVIG+RG +LSGGQK R+ +AR++ ++ + LLD+ SA+D + + +
Sbjct: 516 DLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFE 575
Query: 476 AALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAK-GFYHKLVTSG 534
+ + + T+ V+H+L + +I+ + G ++++GT+ E +K+ F L
Sbjct: 576 LCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDN 635
Query: 535 KETKEPEEIGTVLEEQETKQNGELQPAVRPEPDVK 569
+E+++P GT T + P +K
Sbjct: 636 EESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLK 670
Score = 72.1 bits (169), Expect = 1e-11
Identities = 59/225 (26%), Positives = 97/225 (43%), Gaps = 18/225 (8%)
Query: 924 LKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRK 983
L+G+ V G+ +A+VG G GKS++L + P+ G + + G
Sbjct: 428 LQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHG-------------- 473
Query: 984 QLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXX 1043
++ V Q+P +F TL NI +G K ++ + L G T
Sbjct: 474 RIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKD---LQLLEDGDLTVIGD 530
Query: 1044 XXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTE-ALDHAAKGRTCITI 1102
K RV +ARA+ + + LLD+ SA+DA R + E + + I +
Sbjct: 531 RGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILV 590
Query: 1103 AHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSKQQN 1147
H+L +K A I +L GK+V+KG + E + + L K+ N
Sbjct: 591 THQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDN 635
>AF022853-2|AAB83983.1| 1450|Homo sapiens multidrug resistance
protein protein.
Length = 1450
Score = 112 bits (270), Expect = 6e-24
Identities = 116/476 (24%), Positives = 205/476 (43%), Gaps = 31/476 (6%)
Query: 75 NLMKLKEGMGEKLAVVSNLVGTSIICLCTAFPLGW----KLALACITVMPFSIMASVALT 130
NLM + LA N++ ++ + + A L W LA + VM + + +
Sbjct: 409 NLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMA 468
Query: 131 NYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAFGGENIEVQRYKSLLEPAEISGSRRGL 190
+ M+S K E+L +K + + E + ++ + E+ ++
Sbjct: 469 MKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQE-ELKVLKKSA 527
Query: 191 FTGLGNGFNWVLTYSLNTIGFMYGTRLIIEDANKPDDERTYIIGIVLSITFSVYMATQSI 250
+ F WV T L + + + I D N D +T + + L F++ +I
Sbjct: 528 YLSAVGTFTWVCTPFLVAL-CTFAVYVTI-DENNILDAQTAFVSLAL---FNILRFPLNI 582
Query: 251 TLCVPHMEVFATARGAAASIFSLLDKHPKIDCLSEAGSSPRRVIGEISLEDVHFSYPSRS 310
V V A+ IF L + + D + I++ + F++ +RS
Sbjct: 583 LPMVISSIVQASVSLKRLRIF-LSHEELEPDSIERRPVKDGGGTNSITVRNATFTW-ARS 640
Query: 311 DIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGW 370
D L G + I G VA+VG GCGKS++L L D +G V + G
Sbjct: 641 DPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG---------- 690
Query: 371 LRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAH-EFIKNLPNGYETVI 429
S+ V Q+ + ++ +NI G E YR A A ++ LP+G T I
Sbjct: 691 ---SVAYVPQQAWIQNDSLRENILFGCQ--LEEPYYRSVIQACALLPDLEILPSGDRTEI 745
Query: 430 GERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-QAALDRASV--GRT 486
GE+G +LSGGQKQR+++AR++ + L D+ SA+D H K + + + + +T
Sbjct: 746 GEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKT 805
Query: 487 TLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSGKETKEPEE 542
+ V+H +S + II M G I E G++ EL+ G + + + + T++ ++
Sbjct: 806 RILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQD 861
Score = 80.2 bits (189), Expect = 4e-14
Identities = 61/245 (24%), Positives = 107/245 (43%), Gaps = 21/245 (8%)
Query: 898 QDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRF 957
+D + + ++ + F++ R+ L GI + G VA+VG GCGKS++L +
Sbjct: 620 KDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAE 678
Query: 958 YDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEX 1017
D G++ + G + V Q+ + + +L ENI +G +P
Sbjct: 679 MDKVEGHVAIKG--------------SVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSV 724
Query: 1018 XXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSA 1077
+ LP G T KQRV +ARA+ + + L D+ SA
Sbjct: 725 IQACALLPD---LEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSA 781
Query: 1078 LDANSERAVTEAL---DHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIG 1134
+DA+ + + E + K +T I + H ++ + D+I V+ GKI E G++ EL+
Sbjct: 782 VDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLA 841
Query: 1135 LKGHY 1139
G +
Sbjct: 842 RDGAF 846
Score = 75.4 bits (177), Expect = 1e-12
Identities = 87/395 (22%), Positives = 170/395 (43%), Gaps = 24/395 (6%)
Query: 49 LTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAV----VSNLVGTSIICLCTA 104
L ++LR M++F+ NL ++ S+ L + + E + + + N++G I+ L A
Sbjct: 1037 LHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILL-A 1095
Query: 105 FPLGWKLALACITVMPFSIMASVALTNYQTKS-SIREMESYSQAGKQAE--EVLKSVKTV 161
P+ A I + P ++ Y S ++ +ES S++ + E L V +
Sbjct: 1096 TPI------AAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVI 1149
Query: 162 VAFGGENIEVQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMYGTRLIIED 221
AF E E ++S L+ E +++ + + W L L +G +
Sbjct: 1150 RAF--EEQERFIHQSDLKVDE---NQKAYYPSIVAN-RW-LAVRLECVGNCIVLFAALFA 1202
Query: 222 ANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKID 281
++G+ +S + V + ME A +S +K
Sbjct: 1203 VISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKE-YSETEKEAPWQ 1261
Query: 282 CLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTI 341
A S +G + + Y D +L+ ++ I GE V +VG +G GKS++
Sbjct: 1262 IQETAPPSSWPQVGRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSL 1320
Query: 342 LQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEAT 401
L R+ + +G + +DG N+ + + LR + ++ Q+PVLF G++ N+ + + +
Sbjct: 1321 TLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD-PFSQYS 1379
Query: 402 SEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASL 436
E+V+ E+A+ +F+ LP+ + E G +L
Sbjct: 1380 DEEVWTSLELAHLKDFVSALPDKLDHECAEGGENL 1414
Score = 55.2 bits (127), Expect = 1e-06
Identities = 26/81 (32%), Positives = 51/81 (62%), Gaps = 1/81 (1%)
Query: 923 ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLR 982
+L+ I++ + G+ V +VG +G GKS++ + R + G I +DG++I K + L+ LR
Sbjct: 1293 VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAK-IGLHDLR 1351
Query: 983 KQLGVVQQEPILFDRTLAENI 1003
++ ++ Q+P+LF +L N+
Sbjct: 1352 FKITIIPQDPVLFSGSLRMNL 1372
>AF411579-1|AAL99902.1| 1344|Homo sapiens ATP-binding cassette
protein C11 isoform A protein.
Length = 1344
Score = 111 bits (268), Expect = 1e-23
Identities = 74/220 (33%), Positives = 118/220 (53%), Gaps = 19/220 (8%)
Query: 315 LKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSS 374
L +L + G + + G++G GKS++L + +GSV + G S
Sbjct: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573
Query: 375 LGVVGQEPVLFRGTIYDNIAIG--YPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGER 432
L V Q+ + G I +NI +G Y +A V + + ++ LP G T IGER
Sbjct: 574 LAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSL---NRDLELLPFGDMTEIGER 630
Query: 433 GASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-QAALDRASVGRTTLTVS 491
G +LSGGQKQRI++AR++ + + LLD+ SA+D H K + + + + G+T + V+
Sbjct: 631 GLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVT 690
Query: 492 HRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLV 531
H+L + C +II ++ G I E GTH ELM+ KG Y +L+
Sbjct: 691 HQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI 730
Score = 72.9 bits (171), Expect = 6e-12
Identities = 59/225 (26%), Positives = 99/225 (44%), Gaps = 18/225 (8%)
Query: 924 LKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRK 983
L I+L V G + + G++G GKS++L I G++ + G
Sbjct: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------- 572
Query: 984 QLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXX 1043
L V Q+ + + ENI G K + + LP G T
Sbjct: 573 SLAYVPQQAWIVSGNIRENILMGGAYDKA---RYLQVLHCCSLNRDLELLPFGDMTEIGE 629
Query: 1044 XXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAV-TEALDHAAKGRTCITI 1102
KQR+ +ARA+ ++ LLD+ SA+DA+ + + E + +G+T + +
Sbjct: 630 RGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLV 689
Query: 1103 AHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHYWQLSKQQN 1147
H+L ++ I +L+ GKI E G H+EL+ KG Y QL ++ +
Sbjct: 690 THQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMH 734
Score = 71.7 bits (168), Expect = 1e-11
Identities = 40/119 (33%), Positives = 65/119 (54%), Gaps = 2/119 (1%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
GEI +D H Y + +L G +L I+ E V +VG +G GKS++ L RL +P G
Sbjct: 1139 GEIIFQDYHMKYRDNTPT-VLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAG 1197
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAY 413
+ +DG ++ ++ + LRS L V+ Q+PVL GTI N+ + T + ++ E +
Sbjct: 1198 RILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLD-PFDRHTDQQIWDALERTF 1255
Score = 68.9 bits (161), Expect = 1e-10
Identities = 37/113 (32%), Positives = 58/113 (51%), Gaps = 2/113 (1%)
Query: 891 VDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTV 950
++G + Q W G D Y +L GI+L + + V +VG +G GKS++
Sbjct: 1126 MEGTSCPQGWPQHGEIIFQDYHMKYRDNT-PTVLHGINLTIRGHEVVGIVGRTGSGKSSL 1184
Query: 951 LQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENI 1003
+ R +P G I +DGVDI S+ L LR +L V+ Q+P+L T+ N+
Sbjct: 1185 GMALFRLVEPMAGRILIDGVDIC-SIGLEDLRSKLSVIPQDPVLLSGTIRFNL 1236
Score = 58.0 bits (134), Expect = 2e-07
Identities = 27/81 (33%), Positives = 49/81 (60%), Gaps = 1/81 (1%)
Query: 445 AIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRII 504
A+ R+ L + A++L+DEAT+++D ++ +Q + A G T L ++HR++T++NC I+
Sbjct: 1250 ALERTFLTK-AIILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHIL 1308
Query: 505 CMDQGTIIEQGTHVELMKAKG 525
M G ++E L K G
Sbjct: 1309 VMGNGKVVEFDRPEVLRKKPG 1329
Score = 53.2 bits (122), Expect = 5e-06
Identities = 22/58 (37%), Positives = 39/58 (67%)
Query: 1068 LLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVE 1125
++L+DEAT+++D ++ + + A +G T + IAHR+TT+ + D I V+ GK+VE
Sbjct: 1260 IILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVE 1317
>AC003026-1|AAC05808.1| 691|Homo sapiens Multiple drug resistance
gene MRP1 (partial) protein.
Length = 691
Score = 108 bits (259), Expect = 1e-22
Identities = 84/272 (30%), Positives = 137/272 (50%), Gaps = 24/272 (8%)
Query: 297 ISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSV 356
I++ + F++ +RSD L G + I G VA+VG GCGKS++L L D +G V
Sbjct: 129 ITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHV 187
Query: 357 KLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAH- 415
+ G S+ V Q+ + ++ +NI G E YR A A
Sbjct: 188 AIKG-------------SVAYVPQQAWIQNDSLRENILFGCQ--LEEPYYRSVIQACALL 232
Query: 416 EFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV- 474
++ LP+G T IGE+G +LSGGQKQR+++AR++ + L D+ SA+D H K +
Sbjct: 233 PDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIF 292
Query: 475 QAALDRASV--GRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLV- 531
+ + + +T + V+H +S + II M G I E G++ EL+ G + + +
Sbjct: 293 ENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLR 352
Query: 532 --TSGKETKEPEEIG-TVLEEQETKQNGELQP 560
S ++ ++ EE G TV++E+E G P
Sbjct: 353 TYASTEQEQDAEENGSTVMDEEEAGVTGVSGP 384
Score = 80.2 bits (189), Expect = 4e-14
Identities = 61/245 (24%), Positives = 107/245 (43%), Gaps = 21/245 (8%)
Query: 898 QDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRF 957
+D + + ++ + F++ R+ L GI + G VA+VG GCGKS++L +
Sbjct: 121 KDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAE 179
Query: 958 YDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEX 1017
D G++ + G + V Q+ + + +L ENI +G +P
Sbjct: 180 MDKVEGHVAIKG--------------SVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSV 225
Query: 1018 XXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSA 1077
+ LP G T KQRV +ARA+ + + L D+ SA
Sbjct: 226 IQACALLPD---LEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSA 282
Query: 1078 LDANSERAVTEAL---DHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIG 1134
+DA+ + + E + K +T I + H ++ + D+I V+ GKI E G++ EL+
Sbjct: 283 VDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLA 342
Query: 1135 LKGHY 1139
G +
Sbjct: 343 RDGAF 347
>AY848830-1|AAW33657.1| 241|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
subfam protein.
Length = 241
Score = 107 bits (256), Expect = 3e-22
Identities = 54/211 (25%), Positives = 114/211 (54%), Gaps = 2/211 (0%)
Query: 328 VALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRG 387
V L+G +G GKST+L RL + +G +++DG + ++ + R + GV+ Q+ +F G
Sbjct: 1 VGLLGRTGSGKSTLLSAFLRLLN-TEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSG 59
Query: 388 TIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIA 447
T N+ Y + + +++++VA+ I+ P + V+ + G LS G KQ + +A
Sbjct: 60 TFRKNLD-PYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLA 118
Query: 448 RSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVNCHRIICMD 507
RS+L + +LLLDE ++ LDP + + ++ L +A T + HR+ ++ C + + ++
Sbjct: 119 RSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIE 178
Query: 508 QGTIIEQGTHVELMKAKGFYHKLVTSGKETK 538
+ + + + +L+ + + + ++ K
Sbjct: 179 ENKVRQYDSIQKLLNERSLFRQAISPSDRVK 209
Score = 75.8 bits (178), Expect = 8e-13
Identities = 53/205 (25%), Positives = 95/205 (46%), Gaps = 5/205 (2%)
Query: 937 VALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFD 996
V L+G +G GKST+L R + T G I++DGV S+TL + RK GV+ Q+ +F
Sbjct: 1 VGLLGRTGSGKSTLLSAFLRLLN-TEGEIQIDGVS-WDSITLQQWRKAFGVIPQKVFIFS 58
Query: 997 RTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRV 1056
T +N+ D + + E + I P + KQ +
Sbjct: 59 GTFRKNL---DPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLM 115
Query: 1057 CIARALIRSPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDADIIC 1116
C+AR+++ ++LLLDE ++ LD + + + L A T I HR+ + +
Sbjct: 116 CLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFL 175
Query: 1117 VLDKGKIVEKGNHAELIGLKGHYWQ 1141
V+++ K+ + + +L+ + + Q
Sbjct: 176 VIEENKVRQYDSIQKLLNERSLFRQ 200
>X57521-1|CAA40740.1| 430|Homo sapiens Y3 protein.
Length = 430
Score = 105 bits (251), Expect = 1e-21
Identities = 72/297 (24%), Positives = 144/297 (48%), Gaps = 12/297 (4%)
Query: 51 AVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAVVSNLVGTSIICLCTAFPLGWK 110
AVLRQ+ +F + N+ S+++E+ L + + E L++ + + L
Sbjct: 145 AVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGSVS 204
Query: 111 LALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTVVAFGGENIE 170
L + + +P + + + ++ ES +++ + A E L ++ TV +F E E
Sbjct: 205 LTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGE 264
Query: 171 VQRYKSLLEPAEISGSRRGLFTGLGNGFNWVLTYSLNTIGFMY-GTRLIIEDANKPDDER 229
Q+++ L+ + + + + N + ++ L +G +Y G +L+ A +
Sbjct: 265 AQKFREKLQEIKTLNQKEAVAYAV-NSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLV 323
Query: 230 TYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPKIDCLSEAGSS 289
T+++ + F+ A + + P ++ A G++ IF LD+ P+ C +
Sbjct: 324 TFVL---YQMQFT--QAVEVLLSIYPRVQ---KAVGSSEKIFEYLDRTPR--CPPSGLLT 373
Query: 290 PRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQ 346
P + G + +DV F+YP+R D+ +L+G + ++PGE ALVG +G GKST+ LLQ
Sbjct: 374 PLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQ 430
Score = 68.1 bits (159), Expect = 2e-10
Identities = 75/318 (23%), Positives = 129/318 (40%), Gaps = 23/318 (7%)
Query: 644 TVGSIAAFIQGACFPVFALLLGYTSGEIGYFDRESNTVGAVCARLSGDTAEVQGATGLRI 703
T+G + + +QG VF +L E +F + N G + +R++ DT+ + + +
Sbjct: 130 TMGHVHSHLQGE---VFGAVLRQ---ETEFF--QQNQTGNIMSRVTEDTSTLSDSLSENL 181
Query: 704 GLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGSIWLEGIMSQKSQQDEREAMESA 763
L L + + + LT+V+ LPL+ G Q + RE++ +
Sbjct: 182 SLFLWYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKS 241
Query: 764 TAIATEAVVSIKTVQSLGIESLFITRFQDALIDACAAVVKKS------RWRGLVLGLCIY 817
+ +A EA+ ++ TV+S E +F++ L + K++ W + G+ +
Sbjct: 242 SQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLK 301
Query: 818 VPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXXXXMYGAYMLGQSLVYAPSFNSAKTCGAR 877
V +L G LV G M + L P A +
Sbjct: 302 VGIL------YIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEK 355
Query: 878 ILSIINREPRIRTVDGLNDKQDWSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTV 937
I ++R PR L G DV F+YP R ++L+G+ + G+
Sbjct: 356 IFEYLDRTPRCPPSGLLTPLH---LEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVT 412
Query: 938 ALVGSSGCGKSTVLQLIQ 955
ALVG +G GKSTV L+Q
Sbjct: 413 ALVGPNGSGKSTVAALLQ 430
>U91318-3|AAC15785.1| 848|Homo sapiens Gene product with similarity
to Multidrug resistance protein MRP1 protein.
Length = 848
Score = 103 bits (246), Expect = 5e-21
Identities = 108/452 (23%), Positives = 194/452 (42%), Gaps = 28/452 (6%)
Query: 98 IICLCTAFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKS 157
++C + L AL I V + + ++ + +M + +L++
Sbjct: 396 VVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRN 455
Query: 158 VKTVVAFGGENIEVQRYKSLLEPAEISGSRR-GLFTGLGNGFNWVLTYSLNTIGFMYGTR 216
KT+ G E + R + E+ R GL + V T+ + + F T
Sbjct: 456 SKTIKFHGWEGAFLDRVLGI-RGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAVHT- 513
Query: 217 LIIEDANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDK 276
L+ E+A E+ ++ VL+I + A + + + + + L +
Sbjct: 514 LVAENAMNA--EKAFVTLTVLNI---LNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEV 568
Query: 277 HPKIDCLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGC 336
P + S +GS+ + I++ F++ S L +L + G +A+VG G
Sbjct: 569 DPGVVDSSSSGSAAGKDC--ITIHSATFAWSQESP-PCLHRINLTVPQGCLLAVVGPVGA 625
Query: 337 GKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIG 396
GKS++L L +G V ++G ++ V QE + ++ +N+ G
Sbjct: 626 GKSSLLSALLGELSKVEGFVSIEG-------------AVAYVPQEAWVQNTSVVENVCFG 672
Query: 397 YPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAV 456
E + RV E + + P G T IGE+G +LSGGQKQR+++AR++ R+ AV
Sbjct: 673 Q-ELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAV 731
Query: 457 LLLDEATSALDPHSEKQV-QAALDRASV--GRTTLTVSHRLSTIVNCHRIICMDQGTIIE 513
LLD+ +ALD H + V + + G T + V+H L + II + G I E
Sbjct: 732 YLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAE 791
Query: 514 QGTHVELMKAKGFYHKLVTSGKETKEPEEIGT 545
G++ EL++ KG L+ ++ + E GT
Sbjct: 792 MGSYQELLQRKGALVCLLDQARQPGDRGEGGT 823
Score = 73.7 bits (173), Expect = 3e-12
Identities = 104/476 (21%), Positives = 193/476 (40%), Gaps = 45/476 (9%)
Query: 676 RESNTVGAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTLVST-TF 734
R+++ VG V +S D + + L L G V ++ Y W+L S T
Sbjct: 359 RKASAVGDVVNLVSVDVQRLTESV-----LYLNGLWLPLVWIVVCFVYLWQLLGPSALTA 413
Query: 735 LPLMVGSIWLEGIMSQKSQQDEREAM---ESATAIATEAVVSIKTVQSLGIESLFITRFQ 791
+ + + + L +S+K + E M +S + + + + KT++ G E F+ R
Sbjct: 414 IAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTIKFHGWEGAFLDRVL 473
Query: 792 DALIDACAAVVKKSRWRGLVLGLCIY-VPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXXX 850
A+ R GL+ + + + ++ A++ AV
Sbjct: 474 GIRGQELGAL----RTSGLLFSVSLVSFQVSTFLVALVVFAVHTLVAENAMNAEKAFVTL 529
Query: 851 XMYGAYMLGQSLVYAP----SFNSAKTCGARILSIINREPRIRTVDGLNDKQDWSASGN- 905
+ +L ++ + P S A+ R+++ + E V ++ SA+G
Sbjct: 530 TVLN--ILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDPGV--VDSSSSGSAAGKD 585
Query: 906 -FSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGN 964
+I+ F++ ++ L I+L V G +A+VG G GKS++L + G
Sbjct: 586 CITIHSATFAW-SQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGF 644
Query: 965 IELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXX 1024
+ ++G + V QE + + ++ EN+ +G P ++
Sbjct: 645 VSIEGA--------------VAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQ 690
Query: 1025 XXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDAN-SE 1083
+ S P+G T+ KQR+ +ARA+ R + LLD+ +ALDA+ +
Sbjct: 691 PD---VDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQ 747
Query: 1084 RAVTEALDHAA--KGRTCITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKG 1137
+ + +G T I + H L + AD I VL G I E G++ EL+ KG
Sbjct: 748 HVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKG 803
>AL359813-4|CAI23219.1| 172|Homo sapiens ATP-binding cassette,
sub-family C (CFTR/MRP), member 10 protein.
Length = 172
Score = 98.3 bits (234), Expect = 1e-19
Identities = 56/161 (34%), Positives = 93/161 (57%), Gaps = 7/161 (4%)
Query: 295 GEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQG 354
G + +DV +Y L G + ++PGE + +VG +G GKS++L +L RL +P+ G
Sbjct: 15 GGVEFQDVVLAYRPGLP-NALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSG 73
Query: 355 SVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSED--VYRVAEMA 412
V LDG + L + LRS L ++ QEP LF GT+ +N+ P+ +D +++ +
Sbjct: 74 RVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLD---PQGLHKDRALWQALKQC 130
Query: 413 YAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLRE 453
+ E I ++ G + +GE G SLS GQ+Q + +AR+LL +
Sbjct: 131 HLSEVITSM-GGLDGELGEGGRSLSLGQRQLLCLARALLTD 170
Score = 76.2 bits (179), Expect = 6e-13
Identities = 39/104 (37%), Positives = 59/104 (56%), Gaps = 2/104 (1%)
Query: 900 WSASGNFSINDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYD 959
W G DV +Y L G+ V+ G+ + +VG +G GKS++L ++ R +
Sbjct: 11 WLTQGGVEFQDVVLAYRPGLPNA-LDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLE 69
Query: 960 PTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENI 1003
P++G + LDGVD T L L +LR QL ++ QEP LF T+ EN+
Sbjct: 70 PSSGRVLLDGVD-TSQLELAQLRSQLAIIPQEPFLFSGTVRENL 112
>BC017348-1|AAH17348.1| 596|Homo sapiens ABCB9 protein protein.
Length = 596
Score = 95.9 bits (228), Expect = 7e-19
Identities = 76/332 (22%), Positives = 151/332 (45%), Gaps = 18/332 (5%)
Query: 44 IRKLFLTAVLRQDMTWFDTDSDFNLASKMSENLMKLKEGMGEKLAV-VSNLVGTSIICLC 102
+R +++ Q+ ++FD + +L S+++ + + + + + + V + N V + + +
Sbjct: 261 LRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVF 320
Query: 103 TAFPLGWKLALACITVMPFSIMASVALTNYQTKSSIREMESYSQAGKQAEEVLKSVKTVV 162
F L W+L+L P +M S Y + S + ++A AEE + ++KTV
Sbjct: 321 M-FSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVR 379
Query: 163 AFGGENIEVQRYKSLLEPAEISGSRRG---LFTGLGNGFNWVLTYSLNTIGFMYGTRLII 219
+F E E + Y L+ + ++ G+G +L ++ + YG L+I
Sbjct: 380 SFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLT-LLVVQVSIL--YYGGHLVI 436
Query: 220 EDANKPDDERTYIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKHPK 279
+ +II F + +S+ + GAA +F +D+ P
Sbjct: 437 SGQMTSGNLIAFII-----YEFVLGDCMESVGSVYSGL---MQGVGAAEKVFEFIDRQPT 488
Query: 280 IDCLSEAGSSPRRVIGEISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKS 339
+ + + +P + G + E+V F+Y +R ++L+ S + PG+ ALVG SG GKS
Sbjct: 489 M--VHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKS 546
Query: 340 TILQLLQRLYDPNQGSVKLDGRNLKTLNIGWL 371
+ + +L+ Y G V LDG+ + + +L
Sbjct: 547 SCVNILENFYPLEGGRVLLDGKPISAYDHKYL 578
Score = 89.4 bits (212), Expect = 6e-17
Identities = 90/349 (25%), Positives = 146/349 (41%), Gaps = 30/349 (8%)
Query: 643 LTVGS-IAAFIQGACFP-VFA---------LLLGYTSGEIGYFDRESNTVGAVCARLSGD 691
L +GS AA I+G F +FA L S E +FD N G + +RL+ D
Sbjct: 235 LAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDE--NRTGDLISRLTSD 292
Query: 692 TAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGSIWLEGIMSQK 751
T V I + L+ VT + S +W+L+LV+ P+++ + G ++
Sbjct: 293 TTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKR 352
Query: 752 SQQDEREAMESATAIATEAVVSIKTVQSLGIES----LFITRFQDA--LIDACAAVVKKS 805
++ + A+ A+ A E + ++KTV+S E +++ + Q L AA
Sbjct: 353 LSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYY 412
Query: 806 RWRGLVLGLCIYVPLLSYCSAVIYGAVLVAHGXXXXXXXXXXXXXX-MYGAYMLGQSLVY 864
W GL + L+ S + YG LV G + G M VY
Sbjct: 413 VWGS---GLTL---LVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVY 466
Query: 865 APSFNSAKTCGARILSIINREPRIRTVDGLNDKQDWSASGNFSINDVEFSYPTRAHQMIL 924
+ ++ I+R+P + L G +V F+Y TR H +L
Sbjct: 467 SGLMQGVGAA-EKVFEFIDRQPTMVHDGSLAPDH---LEGRVDFENVTFTYRTRPHTQVL 522
Query: 925 KGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDIT 973
+ + + GK ALVG SG GKS+ + +++ FY G + LDG I+
Sbjct: 523 QNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPIS 571
>AL359813-5|CAI23220.1| 157|Homo sapiens ATP-binding cassette,
sub-family C (CFTR/MRP), member 10 protein.
Length = 157
Score = 94.7 bits (225), Expect = 2e-18
Identities = 53/145 (36%), Positives = 86/145 (59%), Gaps = 9/145 (6%)
Query: 315 LKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSS 374
L G + ++PGE + +VG +G GKS++L +L RL +P+ G V LDG + L + LRS
Sbjct: 14 LDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQ 73
Query: 375 LGVVGQEPVLFRGTIYDNIAIGYPEATSED--VYRVAEMAYAHEFIKN----LPNGYETV 428
L ++ QEP LF GT+ +N+ P+ +D +++ + + E I + L G +
Sbjct: 74 LAIIPQEPFLFSGTVRENLD---PQGLHKDRALWQALKQCHLSEVITSMDAFLAGGLDGE 130
Query: 429 IGERGASLSGGQKQRIAIARSLLRE 453
+GE G SLS GQ+Q + +AR+LL +
Sbjct: 131 LGEGGRSLSLGQRQLLCLARALLTD 155
Score = 72.9 bits (171), Expect = 6e-12
Identities = 43/141 (30%), Positives = 70/141 (49%), Gaps = 2/141 (1%)
Query: 924 LKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRK 983
L G+ V+ G+ + +VG +G GKS++L ++ R +P++G + LDGVD T L L +LR
Sbjct: 14 LDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVD-TSQLELAQLRS 72
Query: 984 QLGVVQQEPILFDRTLAENI-AYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXX 1042
QL ++ QEP LF T+ EN+ G + + + L G +
Sbjct: 73 QLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCHLSEVITSMDAFLAGGLDGELG 132
Query: 1043 XXXXXXXXXXKQRVCIARALI 1063
+Q +C+ARAL+
Sbjct: 133 EGGRSLSLGQRQLLCLARALL 153
>AB209084-1|BAD92321.1| 1011|Homo sapiens Sulfonylurea receptor 1
variant protein.
Length = 1011
Score = 92.3 bits (219), Expect = 9e-18
Identities = 79/250 (31%), Positives = 120/250 (48%), Gaps = 21/250 (8%)
Query: 312 IKILKGFSLHIKPGESVALVGSSGCGKSTILQL----LQR---------LYDPNQGSVKL 358
I L ++ I G+ +VG GCGKS++L +Q+ L D G
Sbjct: 697 IPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPS 756
Query: 359 DGRNLKT-LNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEF 417
R T L+I R + Q+P L T+ +NI P + V E
Sbjct: 757 PERETATDLDIR-KRGPVAYASQKPWLLNATVEENIIFESP-FNKQRYKMVIEACSLQPD 814
Query: 418 IKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPH-SEKQVQA 476
I LP+G +T IGERG +LSGGQ+QRI++AR+L + V+ LD+ SALD H S+ +QA
Sbjct: 815 IDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLMQA 874
Query: 477 ALDR--ASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKG--FYHKLVT 532
+ RT + V+H+L + + II M GTI +GT + +++ F H
Sbjct: 875 GILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKTL 934
Query: 533 SGKETKEPEE 542
++ +E E+
Sbjct: 935 MNRQDQELEK 944
Score = 54.0 bits (124), Expect = 3e-06
Identities = 53/219 (24%), Positives = 90/219 (41%), Gaps = 18/219 (8%)
Query: 924 LKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNI---ELDGVDITKSLTLNR 980
L I + + G+ +VG GCGKS++L +G + L +I + + R
Sbjct: 700 LSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPSPER 759
Query: 981 -------LRKQ--LGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIV 1031
+RK+ + Q+P L + T+ ENI + K I
Sbjct: 760 ETATDLDIRKRGPVAYASQKPWLLNATVEENIIFESPFNK---QRYKMVIEACSLQPDID 816
Query: 1032 SLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDAN-SERAVTEAL 1090
LP G +T +QR+ +ARAL + ++ LD+ SALD + S+ + +
Sbjct: 817 ILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLMQAGI 876
Query: 1091 DHAAKG--RTCITIAHRLTTIKDADIICVLDKGKIVEKG 1127
+ RT + + H+L + AD I + G I +G
Sbjct: 877 LELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREG 915
>AB012959-1|BAA88711.1| 63|Homo sapiens sister p-glycoprotein
protein.
Length = 63
Score = 92.3 bits (219), Expect = 9e-18
Identities = 43/63 (68%), Positives = 53/63 (84%)
Query: 1053 KQRVCIARALIRSPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDA 1112
KQR+ IARA++R P++LLLDEATSALD SE+ V ALD A +GRTCI IAHRL+TI++A
Sbjct: 1 KQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNA 60
Query: 1113 DII 1115
DII
Sbjct: 61 DII 63
Score = 84.2 bits (199), Expect = 2e-15
Identities = 40/59 (67%), Positives = 49/59 (83%)
Query: 441 KQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVN 499
KQRIAIAR+++R+P +LLLDEATSALD SEK VQ ALD+A GRT + ++HRLSTI N
Sbjct: 1 KQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQN 59
>AF085691-1|AAD02846.1| 1238|Homo sapiens multidrug
resistance-associated protein 3A protein.
Length = 1238
Score = 91.1 bits (216), Expect = 2e-17
Identities = 67/247 (27%), Positives = 119/247 (48%), Gaps = 22/247 (8%)
Query: 315 LKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSS 374
L + + G VA+VG GCGKS+++ L + +G V + G S
Sbjct: 644 LHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKG-------------S 690
Query: 375 LGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYR-VAEMAYAHEFIKNLPNGYETVIGERG 433
+ V Q+ + T+ +N+ G +A + Y+ E ++ LP G +T IGE+G
Sbjct: 691 VAYVPQQAWIQNCTLQENVLFG--KALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKG 748
Query: 434 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV---QAALDRASVGRTTLTV 490
+LSGGQ+QR+++AR++ + + LLD+ SA+D H K + + G+T + V
Sbjct: 749 INLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLV 808
Query: 491 SHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTS---GKETKEPEEIGTVL 547
+H +S + II + G + E G + L++ G + + + ++ E+ T L
Sbjct: 809 THGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTAL 868
Query: 548 EEQETKQ 554
E E K+
Sbjct: 869 EGAEDKE 875
Score = 66.1 bits (154), Expect = 7e-10
Identities = 50/219 (22%), Positives = 93/219 (42%), Gaps = 20/219 (9%)
Query: 924 LKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRK 983
L +D+ V G VA+VG GCGKS+++ + + G + + G
Sbjct: 644 LHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKG-------------- 689
Query: 984 QLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXX 1043
+ V Q+ + + TL EN+ +G + + LP G +T
Sbjct: 690 SVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLAD---LEMLPGGDQTEIGE 746
Query: 1044 XXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEAL---DHAAKGRTCI 1100
+QRV +ARA+ + LLD+ SA+D++ + + + + + G+T +
Sbjct: 747 KGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRV 806
Query: 1101 TIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLKGHY 1139
+ H ++ + D I VL G++ E G + L+ G +
Sbjct: 807 LVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSF 845
>S83249-1|AAP31917.1| 125|Homo sapiens transporter protein/putative
hormone extrusion pump protein.
Length = 125
Score = 89.0 bits (211), Expect = 8e-17
Identities = 37/98 (37%), Positives = 63/98 (64%)
Query: 438 GGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTI 497
GGQKQR++IAR ++ P +L D+ TSA+D SE VQ ALD+ G TT+ ++ ++S++
Sbjct: 1 GGQKQRLSIARGVVGSPKILFFDDPTSAVDARSENLVQEALDKELAGTTTIVIAEKISSV 60
Query: 498 VNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSGK 535
++ RI+ +D G ++ G H EL+ + Y ++ + K
Sbjct: 61 LHADRILVLDDGRLVGSGLHAELLASSAIYREIYETQK 98
Score = 84.6 bits (200), Expect = 2e-15
Identities = 42/94 (44%), Positives = 60/94 (63%)
Query: 1053 KQRVCIARALIRSPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIKDA 1112
KQR+ IAR ++ SP++L D+ TSA+DA SE V EALD G T I IA +++++ A
Sbjct: 4 KQRLSIARGVVGSPKILFFDDPTSAVDARSENLVQEALDKELAGTTTIVIAEKISSVLHA 63
Query: 1113 DIICVLDKGKIVEKGNHAELIGLKGHYWQLSKQQ 1146
D I VLD G++V G HAEL+ Y ++ + Q
Sbjct: 64 DRILVLDDGRLVGSGLHAELLASSAIYREIYETQ 97
>DQ388144-1|ABD72215.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 87.4 bits (207), Expect = 3e-16
Identities = 64/237 (27%), Positives = 115/237 (48%), Gaps = 22/237 (9%)
Query: 300 EDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLD 359
+ + FS S +LK + I+ G+ +A+ GS+G GK+++L ++ +P++G +K
Sbjct: 426 DSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHS 485
Query: 360 GRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYR---VAEMAYAHE 416
GR W+ GTI +NI G S D YR V + E
Sbjct: 486 GRISFCSQFSWIMP-------------GTIKENIIFG----VSYDEYRYRSVIKACQLEE 528
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-Q 475
I V+GE G +LSGGQ+ RI++AR++ ++ + LLD LD +EK++ +
Sbjct: 529 DISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFE 588
Query: 476 AALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAK-GFYHKLV 531
+ + + +T + V+ ++ + +I+ + +G+ GT EL + F KL+
Sbjct: 589 SCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 50.8 bits (116), Expect = 3e-05
Identities = 50/217 (23%), Positives = 90/217 (41%), Gaps = 22/217 (10%)
Query: 923 ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLR 982
+LK I+ +E G+ +A+ GS+G GK+++L +I +P+ G I+ G
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG------------- 486
Query: 983 KQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXX--XHNFIVSLPKGYETN 1040
++ Q + T+ ENI +G + DE I +
Sbjct: 487 -RISFCSQFSWIMPGTIKENIIFG-----VSYDEYRYRSVIKACQLEEDISKFAEKDNIV 540
Query: 1041 XXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEA-LDHAAKGRTC 1099
+ R+ +ARA+ + L LLD LD +E+ + E+ + +T
Sbjct: 541 LGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTR 600
Query: 1100 ITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLK 1136
I + ++ +K AD I +L +G G +EL L+
Sbjct: 601 ILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQ 637
Score = 35.1 bits (77), Expect = 1.5
Identities = 33/116 (28%), Positives = 52/116 (44%), Gaps = 6/116 (5%)
Query: 682 GAVCARLSGDTAEVQGATGLRIGLILQGFSSVTVGFIMAMSYNWKLTLVSTTFLPLMVGS 741
G + R S D A + L I +Q + +G I ++ V+T +P++V
Sbjct: 970 GGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGAIAVVAVLQPYIFVAT--VPVIVAF 1026
Query: 742 IWLEGIMSQKSQQDEREAMESATAIATEAVVSIK---TVQSLGIESLFITRFQDAL 794
I L Q SQQ ++ E + I T V S+K T+++ G + F T F AL
Sbjct: 1027 IMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKAL 1082
>AC000111-1|AAB46352.1| 996|Homo sapiens unknown protein.
Length = 996
Score = 87.4 bits (207), Expect = 3e-16
Identities = 64/237 (27%), Positives = 115/237 (48%), Gaps = 22/237 (9%)
Query: 300 EDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLD 359
+ + FS S +LK + I+ G+ +A+ GS+G GK+++L ++ +P++G +K
Sbjct: 426 DSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHS 485
Query: 360 GRNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYR---VAEMAYAHE 416
GR W+ GTI +NI G S D YR V + E
Sbjct: 486 GRISFCSQFSWIMP-------------GTIKENIIFG----VSYDEYRYRSVIKACQLEE 528
Query: 417 FIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-Q 475
I V+GE G +LSGGQ+ RI++AR++ ++ + LLD LD +EK++ +
Sbjct: 529 DISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFE 588
Query: 476 AALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAK-GFYHKLV 531
+ + + +T + V+ ++ + +I+ + +G+ GT EL + F KL+
Sbjct: 589 SCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 50.8 bits (116), Expect = 3e-05
Identities = 50/217 (23%), Positives = 90/217 (41%), Gaps = 22/217 (10%)
Query: 923 ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLR 982
+LK I+ +E G+ +A+ GS+G GK+++L +I +P+ G I+ G
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG------------- 486
Query: 983 KQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXX--XHNFIVSLPKGYETN 1040
++ Q + T+ ENI +G + DE I +
Sbjct: 487 -RISFCSQFSWIMPGTIKENIIFG-----VSYDEYRYRSVIKACQLEEDISKFAEKDNIV 540
Query: 1041 XXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEA-LDHAAKGRTC 1099
+ R+ +ARA+ + L LLD LD +E+ + E+ + +T
Sbjct: 541 LGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTR 600
Query: 1100 ITIAHRLTTIKDADIICVLDKGKIVEKGNHAELIGLK 1136
I + ++ +K AD I +L +G G +EL L+
Sbjct: 601 ILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQ 637
>U83660-1|AAB71757.1| 162|Homo sapiens multidrug
resistance-associated protein homolog protein.
Length = 162
Score = 84.6 bits (200), Expect = 2e-15
Identities = 39/117 (33%), Positives = 75/117 (64%), Gaps = 1/117 (0%)
Query: 416 EFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQ 475
E I++LP +T + E G++ S GQ+Q + +AR++LR+ +L++DEAT+ +DP +++ +Q
Sbjct: 3 ETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELIQ 62
Query: 476 AALDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIE-QGTHVELMKAKGFYHKLV 531
+ T LT++HRL+TI++ +I+ +D G + E +V L + ++K+V
Sbjct: 63 KKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMV 119
Score = 68.5 bits (160), Expect = 1e-10
Identities = 34/96 (35%), Positives = 54/96 (56%)
Query: 1030 IVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEA 1089
I LP +T +Q VC+ARA++R ++L++DEAT+ +D ++ + +
Sbjct: 5 IEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELIQKK 64
Query: 1090 LDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVE 1125
+ T +TIAHRL TI D+D I VLD G++ E
Sbjct: 65 IREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKE 100
>BC125232-1|AAI25233.1| 1500|Homo sapiens ABCA6 protein protein.
Length = 1500
Score = 81.8 bits (193), Expect = 1e-14
Identities = 69/251 (27%), Positives = 119/251 (47%), Gaps = 9/251 (3%)
Query: 297 ISLEDVHFSYPSRSD-IKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGS 355
I + +V Y +S ++ LKG I G+ A++G SG GKS++L +L L P +GS
Sbjct: 478 IRIRNVKKEYKGKSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEGS 537
Query: 356 VKLDGRNLKTL-NIGWLRSSLGVVGQEPVLFR-GTIYDNIAIGYPEATSEDVYRVAEMAY 413
V + +NL + ++ +R GV Q V F T+ +N+++ A + ++ + E+
Sbjct: 538 VTIYNKNLSEMQDLEEIRKITGVCPQFNVQFDILTVKENLSL---FAKIKGIH-LKEVEQ 593
Query: 414 AHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQ 473
+ I L + + LS GQK+++ ++L +P +LLLDE T+ LDP S Q
Sbjct: 594 EVQRIL-LELDMQNIQDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQ 652
Query: 474 VQAALDRASVGRTTLTVSHRLSTI-VNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVT 532
V + L L + + + R + M G + G+ + L + G + L
Sbjct: 653 VWSLLRERRADHVILFSTQSMDEADILADRKVIMSNGRLKCAGSSMFLKRRWGLGYHLSL 712
Query: 533 SGKETKEPEEI 543
E PE+I
Sbjct: 713 HRNEICNPEQI 723
Score = 55.6 bits (128), Expect = 1e-06
Identities = 52/222 (23%), Positives = 98/222 (44%), Gaps = 14/222 (6%)
Query: 908 INDVEFSYPTRAHQM-ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIE 966
I +V+ Y ++ ++ LKG+ + G+ A++G SG GKS++L ++ PT G++
Sbjct: 480 IRNVKKEYKGKSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEGSVT 539
Query: 967 LDGVDITKSLTLNRLRKQLGVVQQEPILFD-RTLAENIAYGDNSRKPTMDEXXXXXXXXX 1025
+ ++++ L +RK GV Q + FD T+ EN++ + + E
Sbjct: 540 IYNKNLSEMQDLEEIRKITGVCPQFNVQFDILTVKENLSLFAKIKGIHLKEVEQEVQR-- 597
Query: 1026 XHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERA 1085
+ L + K+++ ++ P++LLLDE T+ LD S
Sbjct: 598 -----ILLELDMQNIQDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQ 652
Query: 1086 VTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKG 1127
V L + R I ++ +ADI+ D+ I+ G
Sbjct: 653 VWSLL---RERRADHVILFSTQSMDEADILA--DRKVIMSNG 689
Score = 50.0 bits (114), Expect = 5e-05
Identities = 50/200 (25%), Positives = 91/200 (45%), Gaps = 16/200 (8%)
Query: 316 KGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSL 375
+ S ++ GE + L+G SG GKS+ ++++ + P G V+L G + + L
Sbjct: 1304 RNISFCVQEGEILGLLGPSGAGKSSSIRMISGITKPTAGEVELKGCSS-------VLGHL 1356
Query: 376 GVVGQEPVLFRG-TIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGA 434
G QE VL+ T+ +++ + Y R A+ A + + +E +
Sbjct: 1357 GYCPQENVLWPMLTLREHLEV-YAAVKG---LRKADARLAIARLVSAFKLHEQ-LNVPVQ 1411
Query: 435 SLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRA--SVGRTTLTVSH 492
L+ G +++ SLL VLLLDE ++ +DP ++Q+ A+ + R L +H
Sbjct: 1412 KLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVLLTTH 1471
Query: 493 RLSTI-VNCHRIICMDQGTI 511
L+ C R+ M G +
Sbjct: 1472 NLAEAEALCDRVAIMVSGRL 1491
Score = 45.6 bits (103), Expect = 0.001
Identities = 47/214 (21%), Positives = 90/214 (42%), Gaps = 21/214 (9%)
Query: 915 YPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITK 974
+ R ++ + I V+ G+ + L+G SG GKS+ +++I PT G +EL G
Sbjct: 1294 FSKRKKKIAARNISFCVQEGEILGLLGPSGAGKSSSIRMISGITKPTAGEVELKG----- 1348
Query: 975 SLTLNRLRKQLGVVQQEPILFDR-TLAENI-AYGDNSRKPTMDEXXXXXXXXXXHNFIVS 1032
+ + LG QE +L+ TL E++ Y D +VS
Sbjct: 1349 ---CSSVLGHLGYCPQENVLWPMLTLREHLEVYAAVKGLRKADARLAIAR-------LVS 1398
Query: 1033 LPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEALDH 1092
K +E +++C +L+ + +LLLDE ++ +D ++ + +A+
Sbjct: 1399 AFKLHE-QLNVPVQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQA 1457
Query: 1093 AAKG--RTCITIAHRLTTIKD-ADIICVLDKGKI 1123
K R + H L + D + ++ G++
Sbjct: 1458 VVKNTERGVLLTTHNLAEAEALCDRVAIMVSGRL 1491
>BC125231-1|AAI25232.1| 1500|Homo sapiens ABCA6 protein protein.
Length = 1500
Score = 81.8 bits (193), Expect = 1e-14
Identities = 69/251 (27%), Positives = 119/251 (47%), Gaps = 9/251 (3%)
Query: 297 ISLEDVHFSYPSRSD-IKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGS 355
I + +V Y +S ++ LKG I G+ A++G SG GKS++L +L L P +GS
Sbjct: 478 IRIRNVKKEYKGKSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEGS 537
Query: 356 VKLDGRNLKTL-NIGWLRSSLGVVGQEPVLFR-GTIYDNIAIGYPEATSEDVYRVAEMAY 413
V + +NL + ++ +R GV Q V F T+ +N+++ A + ++ + E+
Sbjct: 538 VTIYNKNLSEMQDLEEIRKITGVCPQFNVQFDILTVKENLSL---FAKIKGIH-LKEVEQ 593
Query: 414 AHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQ 473
+ I L + + LS GQK+++ ++L +P +LLLDE T+ LDP S Q
Sbjct: 594 EVQRIL-LELDMQNIQDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQ 652
Query: 474 VQAALDRASVGRTTLTVSHRLSTI-VNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVT 532
V + L L + + + R + M G + G+ + L + G + L
Sbjct: 653 VWSLLRERRADHVILFSTQSMDEADILADRKVIMSNGRLKCAGSSMFLKRRWGLGYHLSL 712
Query: 533 SGKETKEPEEI 543
E PE+I
Sbjct: 713 HRNEICNPEQI 723
Score = 55.6 bits (128), Expect = 1e-06
Identities = 52/222 (23%), Positives = 98/222 (44%), Gaps = 14/222 (6%)
Query: 908 INDVEFSYPTRAHQM-ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIE 966
I +V+ Y ++ ++ LKG+ + G+ A++G SG GKS++L ++ PT G++
Sbjct: 480 IRNVKKEYKGKSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEGSVT 539
Query: 967 LDGVDITKSLTLNRLRKQLGVVQQEPILFD-RTLAENIAYGDNSRKPTMDEXXXXXXXXX 1025
+ ++++ L +RK GV Q + FD T+ EN++ + + E
Sbjct: 540 IYNKNLSEMQDLEEIRKITGVCPQFNVQFDILTVKENLSLFAKIKGIHLKEVEQEVQR-- 597
Query: 1026 XHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERA 1085
+ L + K+++ ++ P++LLLDE T+ LD S
Sbjct: 598 -----ILLELDMQNIQDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQ 652
Query: 1086 VTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKG 1127
V L + R I ++ +ADI+ D+ I+ G
Sbjct: 653 VWSLL---RERRADHVILFSTQSMDEADILA--DRKVIMSNG 689
Score = 50.0 bits (114), Expect = 5e-05
Identities = 50/200 (25%), Positives = 91/200 (45%), Gaps = 16/200 (8%)
Query: 316 KGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSL 375
+ S ++ GE + L+G SG GKS+ ++++ + P G V+L G + + L
Sbjct: 1304 RNISFCVQEGEILGLLGPSGAGKSSSIRMISGITKPTAGEVELKGCSS-------VLGHL 1356
Query: 376 GVVGQEPVLFRG-TIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGA 434
G QE VL+ T+ +++ + Y R A+ A + + +E +
Sbjct: 1357 GYCPQENVLWPMLTLREHLEV-YAAVKG---LRKADARLAIARLVSAFKLHEQ-LNVPVQ 1411
Query: 435 SLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRA--SVGRTTLTVSH 492
L+ G +++ SLL VLLLDE ++ +DP ++Q+ A+ + R L +H
Sbjct: 1412 KLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVLLTTH 1471
Query: 493 RLSTI-VNCHRIICMDQGTI 511
L+ C R+ M G +
Sbjct: 1472 NLAEAEALCDRVAIMVSGRL 1491
Score = 45.6 bits (103), Expect = 0.001
Identities = 47/214 (21%), Positives = 90/214 (42%), Gaps = 21/214 (9%)
Query: 915 YPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITK 974
+ R ++ + I V+ G+ + L+G SG GKS+ +++I PT G +EL G
Sbjct: 1294 FSKRKKKIAARNISFCVQEGEILGLLGPSGAGKSSSIRMISGITKPTAGEVELKG----- 1348
Query: 975 SLTLNRLRKQLGVVQQEPILFDR-TLAENI-AYGDNSRKPTMDEXXXXXXXXXXHNFIVS 1032
+ + LG QE +L+ TL E++ Y D +VS
Sbjct: 1349 ---CSSVLGHLGYCPQENVLWPMLTLREHLEVYAAVKGLRKADARLAIAR-------LVS 1398
Query: 1033 LPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEALDH 1092
K +E +++C +L+ + +LLLDE ++ +D ++ + +A+
Sbjct: 1399 AFKLHE-QLNVPVQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQA 1457
Query: 1093 AAKG--RTCITIAHRLTTIKD-ADIICVLDKGKI 1123
K R + H L + D + ++ G++
Sbjct: 1458 VVKNTERGVLLTTHNLAEAEALCDRVAIMVSGRL 1491
>AY028898-1|AAK30023.1| 1617|Homo sapiens ATP-binding cassette A6
protein.
Length = 1617
Score = 81.8 bits (193), Expect = 1e-14
Identities = 69/251 (27%), Positives = 119/251 (47%), Gaps = 9/251 (3%)
Query: 297 ISLEDVHFSYPSRSD-IKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGS 355
I + +V Y +S ++ LKG I G+ A++G SG GKS++L +L L P +GS
Sbjct: 478 IRIRNVKKEYKGKSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEGS 537
Query: 356 VKLDGRNLKTL-NIGWLRSSLGVVGQEPVLFR-GTIYDNIAIGYPEATSEDVYRVAEMAY 413
V + +NL + ++ +R GV Q V F T+ +N+++ A + ++ + E+
Sbjct: 538 VTIYNKNLSEMQDLEEIRKITGVCPQFNVQFDILTVKENLSL---FAKIKGIH-LKEVEQ 593
Query: 414 AHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQ 473
+ I L + + LS GQK+++ ++L +P +LLLDE T+ LDP S Q
Sbjct: 594 EVQRIL-LELDMQNIQDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQ 652
Query: 474 VQAALDRASVGRTTLTVSHRLSTI-VNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVT 532
V + L L + + + R + M G + G+ + L + G + L
Sbjct: 653 VWSLLRERRADHVILFSTQSMDEADILADRKVIMSNGRLKCAGSSMFLKRRWGLGYHLSL 712
Query: 533 SGKETKEPEEI 543
E PE+I
Sbjct: 713 HRNEICNPEQI 723
Score = 55.6 bits (128), Expect = 1e-06
Identities = 52/222 (23%), Positives = 98/222 (44%), Gaps = 14/222 (6%)
Query: 908 INDVEFSYPTRAHQM-ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIE 966
I +V+ Y ++ ++ LKG+ + G+ A++G SG GKS++L ++ PT G++
Sbjct: 480 IRNVKKEYKGKSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEGSVT 539
Query: 967 LDGVDITKSLTLNRLRKQLGVVQQEPILFD-RTLAENIAYGDNSRKPTMDEXXXXXXXXX 1025
+ ++++ L +RK GV Q + FD T+ EN++ + + E
Sbjct: 540 IYNKNLSEMQDLEEIRKITGVCPQFNVQFDILTVKENLSLFAKIKGIHLKEVEQEVQR-- 597
Query: 1026 XHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERA 1085
+ L + K+++ ++ P++LLLDE T+ LD S
Sbjct: 598 -----ILLELDMQNIQDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQ 652
Query: 1086 VTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKG 1127
V L + R I ++ +ADI+ D+ I+ G
Sbjct: 653 VWSLL---RERRADHVILFSTQSMDEADILA--DRKVIMSNG 689
Score = 52.4 bits (120), Expect = 9e-06
Identities = 57/228 (25%), Positives = 101/228 (44%), Gaps = 16/228 (7%)
Query: 316 KGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSL 375
+ S ++ GE + L+G SG GKS+ ++++ + P G V+L G + + L
Sbjct: 1304 RNISFCVQEGEILGLLGPSGAGKSSSIRMISGITKPTAGEVELKGCSS-------VLGHL 1356
Query: 376 GVVGQEPVLFRG-TIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGA 434
G QE VL+ T+ +++ + Y R A+ A + + +E +
Sbjct: 1357 GYCPQENVLWPMLTLREHLEV-YAAVKG---LRKADARLAIARLVSAFKLHEQ-LNVPVQ 1411
Query: 435 SLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRA--SVGRTTLTVSH 492
L+ G +++ SLL VLLLDE ++ +DP ++Q+ A+ + R L +H
Sbjct: 1412 KLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVLLTTH 1471
Query: 493 RLSTI-VNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSGKETKE 539
L+ C R+ M G + G+ L G + L KET +
Sbjct: 1472 NLAEAEALCDRVAIMVSGRLRCIGSIQHLKNKLGKDYILELKVKETSQ 1519
Score = 45.6 bits (103), Expect = 0.001
Identities = 47/214 (21%), Positives = 90/214 (42%), Gaps = 21/214 (9%)
Query: 915 YPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITK 974
+ R ++ + I V+ G+ + L+G SG GKS+ +++I PT G +EL G
Sbjct: 1294 FSKRKKKIAARNISFCVQEGEILGLLGPSGAGKSSSIRMISGITKPTAGEVELKG----- 1348
Query: 975 SLTLNRLRKQLGVVQQEPILFDR-TLAENI-AYGDNSRKPTMDEXXXXXXXXXXHNFIVS 1032
+ + LG QE +L+ TL E++ Y D +VS
Sbjct: 1349 ---CSSVLGHLGYCPQENVLWPMLTLREHLEVYAAVKGLRKADARLAIAR-------LVS 1398
Query: 1033 LPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEALDH 1092
K +E +++C +L+ + +LLLDE ++ +D ++ + +A+
Sbjct: 1399 AFKLHE-QLNVPVQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQA 1457
Query: 1093 AAKG--RTCITIAHRLTTIKD-ADIICVLDKGKI 1123
K R + H L + D + ++ G++
Sbjct: 1458 VVKNTERGVLLTTHNLAEAEALCDRVAIMVSGRL 1491
>AK094171-1|BAC04300.1| 120|Homo sapiens protein ( Homo sapiens
cDNA FLJ36852 fis, clone ASTRO2014392, moderately
similar to SULFONYLUREA RECEPTOR 1. ).
Length = 120
Score = 81.8 bits (193), Expect = 1e-14
Identities = 37/104 (35%), Positives = 66/104 (63%)
Query: 418 IKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAA 477
+K+LP G + V+ E G + S GQ+Q +AR+ +R+ ++L++DEAT+++D +E +Q
Sbjct: 2 VKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKV 61
Query: 478 LDRASVGRTTLTVSHRLSTIVNCHRIICMDQGTIIEQGTHVELM 521
+ A RT +T++HR+ TI+ +I M +G I+E T L+
Sbjct: 62 VMTAFADRTVVTIAHRVHTILTADLVIVMKRGNILEYDTPESLL 105
Score = 68.9 bits (161), Expect = 1e-10
Identities = 33/96 (34%), Positives = 55/96 (57%)
Query: 1030 IVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEA 1089
+ SLP G + +Q C+ARA +R +L++DEAT+++D +E + +
Sbjct: 2 VKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKV 61
Query: 1090 LDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVE 1125
+ A RT +TIAHR+ TI AD++ V+ +G I+E
Sbjct: 62 VMTAFADRTVVTIAHRVHTILTADLVIVMKRGNILE 97
>AF373328-1|AAM77558.1| 1617|Homo sapiens ABC transporter ABCA6
protein.
Length = 1617
Score = 81.8 bits (193), Expect = 1e-14
Identities = 69/251 (27%), Positives = 119/251 (47%), Gaps = 9/251 (3%)
Query: 297 ISLEDVHFSYPSRSD-IKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGS 355
I + +V Y +S ++ LKG I G+ A++G SG GKS++L +L L P +GS
Sbjct: 478 IRIRNVKKEYKGKSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEGS 537
Query: 356 VKLDGRNLKTL-NIGWLRSSLGVVGQEPVLFR-GTIYDNIAIGYPEATSEDVYRVAEMAY 413
V + +NL + ++ +R GV Q V F T+ +N+++ A + ++ + E+
Sbjct: 538 VTIYNKNLSEMQDLEEIRKITGVCPQFNVQFDILTVKENLSL---FAKIKGIH-LKEVEQ 593
Query: 414 AHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQ 473
+ I L + + LS GQK+++ ++L +P +LLLDE T+ LDP S Q
Sbjct: 594 EVQRIL-LELDMQNIQDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQ 652
Query: 474 VQAALDRASVGRTTLTVSHRLSTI-VNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVT 532
V + L L + + + R + M G + G+ + L + G + L
Sbjct: 653 VWSLLRERRADHVILFSTQSMDEADILADRKVIMSNGRLKCAGSSMFLKRRWGLGYHLSL 712
Query: 533 SGKETKEPEEI 543
E PE+I
Sbjct: 713 HRNEICNPEQI 723
Score = 55.6 bits (128), Expect = 1e-06
Identities = 52/222 (23%), Positives = 98/222 (44%), Gaps = 14/222 (6%)
Query: 908 INDVEFSYPTRAHQM-ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIE 966
I +V+ Y ++ ++ LKG+ + G+ A++G SG GKS++L ++ PT G++
Sbjct: 480 IRNVKKEYKGKSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEGSVT 539
Query: 967 LDGVDITKSLTLNRLRKQLGVVQQEPILFD-RTLAENIAYGDNSRKPTMDEXXXXXXXXX 1025
+ ++++ L +RK GV Q + FD T+ EN++ + + E
Sbjct: 540 IYNKNLSEMQDLEEIRKITGVCPQFNVQFDILTVKENLSLFAKIKGIHLKEVEQEVQR-- 597
Query: 1026 XHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERA 1085
+ L + K+++ ++ P++LLLDE T+ LD S
Sbjct: 598 -----ILLELDMQNIQDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQ 652
Query: 1086 VTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKG 1127
V L + R I ++ +ADI+ D+ I+ G
Sbjct: 653 VWSLL---RERRADHVILFSTQSMDEADILA--DRKVIMSNG 689
Score = 51.2 bits (117), Expect = 2e-05
Identities = 56/228 (24%), Positives = 101/228 (44%), Gaps = 16/228 (7%)
Query: 316 KGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSL 375
+ S ++ GE + L+G +G GKS+ ++++ + P G V+L G + + L
Sbjct: 1304 RNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKGCSS-------VLGHL 1356
Query: 376 GVVGQEPVLFRG-TIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGA 434
G QE VL+ T+ +++ + Y R A+ A + + +E +
Sbjct: 1357 GYCPQENVLWPMLTLREHLEV-YAAVKG---LRKADARLAIARLVSAFKLHEQ-LNVPVQ 1411
Query: 435 SLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRA--SVGRTTLTVSH 492
L+ G +++ SLL VLLLDE ++ +DP ++Q+ A+ + R L +H
Sbjct: 1412 KLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVLLTTH 1471
Query: 493 RLSTI-VNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSGKETKE 539
L+ C R+ M G + G+ L G + L KET +
Sbjct: 1472 NLAEAEALCDRVAIMVSGRLRCIGSIQHLKNKLGKDYILELKVKETSQ 1519
Score = 44.4 bits (100), Expect = 0.002
Identities = 46/214 (21%), Positives = 90/214 (42%), Gaps = 21/214 (9%)
Query: 915 YPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITK 974
+ R ++ + I V+ G+ + L+G +G GKS+ +++I PT G +EL G
Sbjct: 1294 FSKRKKKIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKG----- 1348
Query: 975 SLTLNRLRKQLGVVQQEPILFDR-TLAENI-AYGDNSRKPTMDEXXXXXXXXXXHNFIVS 1032
+ + LG QE +L+ TL E++ Y D +VS
Sbjct: 1349 ---CSSVLGHLGYCPQENVLWPMLTLREHLEVYAAVKGLRKADARLAIAR-------LVS 1398
Query: 1033 LPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEALDH 1092
K +E +++C +L+ + +LLLDE ++ +D ++ + +A+
Sbjct: 1399 AFKLHE-QLNVPVQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQA 1457
Query: 1093 AAKG--RTCITIAHRLTTIKD-ADIICVLDKGKI 1123
K R + H L + D + ++ G++
Sbjct: 1458 VVKNTERGVLLTTHNLAEAEALCDRVAIMVSGRL 1491
>AF373290-1|AAM77557.1| 1617|Homo sapiens ABC transporter ABCA6
protein.
Length = 1617
Score = 81.8 bits (193), Expect = 1e-14
Identities = 69/251 (27%), Positives = 119/251 (47%), Gaps = 9/251 (3%)
Query: 297 ISLEDVHFSYPSRSD-IKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGS 355
I + +V Y +S ++ LKG I G+ A++G SG GKS++L +L L P +GS
Sbjct: 478 IRIRNVKKEYKGKSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEGS 537
Query: 356 VKLDGRNLKTL-NIGWLRSSLGVVGQEPVLFR-GTIYDNIAIGYPEATSEDVYRVAEMAY 413
V + +NL + ++ +R GV Q V F T+ +N+++ A + ++ + E+
Sbjct: 538 VTIYNKNLSEMQDLEEIRKITGVCPQFNVQFDILTVKENLSL---FAKIKGIH-LKEVEQ 593
Query: 414 AHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQ 473
+ I L + + LS GQK+++ ++L +P +LLLDE T+ LDP S Q
Sbjct: 594 EVQRIL-LELDMQNIQDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQ 652
Query: 474 VQAALDRASVGRTTLTVSHRLSTI-VNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVT 532
V + L L + + + R + M G + G+ + L + G + L
Sbjct: 653 VWSLLRERRADHVILFSTQSMDEADILADRKVIMSNGRLKCAGSSMFLKRRWGLGYHLSL 712
Query: 533 SGKETKEPEEI 543
E PE+I
Sbjct: 713 HRNEICNPEQI 723
Score = 55.6 bits (128), Expect = 1e-06
Identities = 52/222 (23%), Positives = 98/222 (44%), Gaps = 14/222 (6%)
Query: 908 INDVEFSYPTRAHQM-ILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIE 966
I +V+ Y ++ ++ LKG+ + G+ A++G SG GKS++L ++ PT G++
Sbjct: 480 IRNVKKEYKGKSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEGSVT 539
Query: 967 LDGVDITKSLTLNRLRKQLGVVQQEPILFD-RTLAENIAYGDNSRKPTMDEXXXXXXXXX 1025
+ ++++ L +RK GV Q + FD T+ EN++ + + E
Sbjct: 540 IYNKNLSEMQDLEEIRKITGVCPQFNVQFDILTVKENLSLFAKIKGIHLKEVEQEVQR-- 597
Query: 1026 XHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERA 1085
+ L + K+++ ++ P++LLLDE T+ LD S
Sbjct: 598 -----ILLELDMQNIQDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQ 652
Query: 1086 VTEALDHAAKGRTCITIAHRLTTIKDADIICVLDKGKIVEKG 1127
V L + R I ++ +ADI+ D+ I+ G
Sbjct: 653 VWSLL---RERRADHVILFSTQSMDEADILA--DRKVIMSNG 689
Score = 51.2 bits (117), Expect = 2e-05
Identities = 56/228 (24%), Positives = 101/228 (44%), Gaps = 16/228 (7%)
Query: 316 KGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSL 375
+ S ++ GE + L+G +G GKS+ ++++ + P G V+L G + + L
Sbjct: 1304 RNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKGCSS-------VLGHL 1356
Query: 376 GVVGQEPVLFRG-TIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGA 434
G QE VL+ T+ +++ + Y R A+ A + + +E +
Sbjct: 1357 GYCPQENVLWPMLTLREHLEV-YAAVKG---LRKADARLAIARLVSAFKLHEQ-LNVPVQ 1411
Query: 435 SLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRA--SVGRTTLTVSH 492
L+ G +++ SLL VLLLDE ++ +DP ++Q+ A+ + R L +H
Sbjct: 1412 KLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVLLTTH 1471
Query: 493 RLSTI-VNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSGKETKE 539
L+ C R+ M G + G+ L G + L KET +
Sbjct: 1472 NLAEAEALCDRVAIMVSGRLRCIGSIQHLKNKLGKDYILELKVKETSQ 1519
Score = 44.4 bits (100), Expect = 0.002
Identities = 46/214 (21%), Positives = 90/214 (42%), Gaps = 21/214 (9%)
Query: 915 YPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITK 974
+ R ++ + I V+ G+ + L+G +G GKS+ +++I PT G +EL G
Sbjct: 1294 FSKRKKKIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKG----- 1348
Query: 975 SLTLNRLRKQLGVVQQEPILFDR-TLAENI-AYGDNSRKPTMDEXXXXXXXXXXHNFIVS 1032
+ + LG QE +L+ TL E++ Y D +VS
Sbjct: 1349 ---CSSVLGHLGYCPQENVLWPMLTLREHLEVYAAVKGLRKADARLAIAR-------LVS 1398
Query: 1033 LPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEALDH 1092
K +E +++C +L+ + +LLLDE ++ +D ++ + +A+
Sbjct: 1399 AFKLHE-QLNVPVQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQA 1457
Query: 1093 AAKG--RTCITIAHRLTTIKD-ADIICVLDKGKI 1123
K R + H L + D + ++ G++
Sbjct: 1458 VVKNTERGVLLTTHNLAEAEALCDRVAIMVSGRL 1491
>BC130280-1|AAI30281.1| 1621|Homo sapiens ABCA8 protein protein.
Length = 1621
Score = 79.0 bits (186), Expect = 9e-14
Identities = 70/259 (27%), Positives = 120/259 (46%), Gaps = 13/259 (5%)
Query: 297 ISLEDVHFSYPSRSD-IKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGS 355
I + +V Y + D I+ LK I G+ A++G SG GKST+L +L L P +GS
Sbjct: 480 IRIRNVTKEYKGKPDKIEALKDLVFDIYEGQITAILGHSGAGKSTLLNILSGLSVPTKGS 539
Query: 356 VKLDGRNLKTL-NIGWLRSSLGVVGQEPVLFRG-TIYDNIAI--GYPEATSEDVYRVAEM 411
V + L + ++ L GV Q V F T+ +N+ + ++V + +
Sbjct: 540 VTIYNNKLSEMADLENLSKLTGVCPQSNVQFDFLTVRENLRLFAKIKGILPQEVDKEIQR 599
Query: 412 AYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSE 471
+KN+ + V+ + +LSGGQK+++ ++L +P + LLDE T+ LDP S
Sbjct: 600 VLLELEMKNI----QDVLAQ---NLSGGQKRKLTFGIAILGDPQIFLLDEPTAGLDPFSR 652
Query: 472 KQVQAALDRASVGRTTLTVSHRLSTI-VNCHRIICMDQGTIIEQGTHVELMKAKGFYHKL 530
QV L R L + + + R + + QG + G+ + L K G + L
Sbjct: 653 HQVWNLLKERKTDRVILFSTQFMDEADILADRKVFLSQGKLKCAGSSLFLKKKWGIGYHL 712
Query: 531 VTSGKETKEPEEIGTVLEE 549
E E I +++++
Sbjct: 713 SLQLNEICVEENITSLVKQ 731
Score = 53.6 bits (123), Expect = 4e-06
Identities = 57/229 (24%), Positives = 91/229 (39%), Gaps = 15/229 (6%)
Query: 924 LKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRK 983
LK + + G+ A++G SG GKST+L ++ PT G++ + +++ L L K
Sbjct: 499 LKDLVFDIYEGQITAILGHSGAGKSTLLNILSGLSVPTKGSVTIYNNKLSEMADLENLSK 558
Query: 984 QLGVVQQEPILFD-RTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXX 1042
GV Q + FD T+ EN+ + E V L +
Sbjct: 559 LTGVCPQSNVQFDFLTVRENLRLFAKIKGILPQEVDKEIQR-------VLLELEMKNIQD 611
Query: 1043 XXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITI 1102
K+++ A++ P++ LLDE T+ LD S V L R I
Sbjct: 612 VLAQNLSGGQKRKLTFGIAILGDPQIFLLDEPTAGLDPFSRHQVWNLLKERKTDR---VI 668
Query: 1103 AHRLTTIKDADIIC----VLDKGKIVEKGNHAELIGLKGHYWQLSKQQN 1147
+ +ADI+ L +GK+ G+ L G + LS Q N
Sbjct: 669 LFSTQFMDEADILADRKVFLSQGKLKCAGSSLFLKKKWGIGYHLSLQLN 717
Score = 48.8 bits (111), Expect = 1e-04
Identities = 55/215 (25%), Positives = 100/215 (46%), Gaps = 19/215 (8%)
Query: 316 KGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSL 375
+ S ++ GE + L+G +G GKST ++++ P G V L G G L
Sbjct: 1307 RNVSFCVRKGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLLKGSGG-----GDALEFL 1361
Query: 376 GVVGQEPVLFRG-TIYDNIAIGYPEATSEDVYRV-AEMAYAHEFIKNLPNGYETVIGERG 433
G QE L+ T+ ++ + A + + + AE+A + L + +
Sbjct: 1362 GYCPQENALWPNLTVRQHLEV---YAAVKGLRKGDAEVAITR-LVDALK--LQDQLKSPV 1415
Query: 434 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRT----TLT 489
+LS G K+++ S+L P+V+LLDE ++ +DP ++Q+ A+ RA+ T LT
Sbjct: 1416 KTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAI-RATFRNTERGALLT 1474
Query: 490 VSHRLSTIVNCHRIICMDQGTIIEQGTHVELMKAK 524
+ C R+ M G + G+ ++ +K+K
Sbjct: 1475 THYMAEAEAVCDRVAIMVSGRLRCIGS-IQHLKSK 1508
Score = 37.9 bits (84), Expect = 0.21
Identities = 34/176 (19%), Positives = 72/176 (40%), Gaps = 12/176 (6%)
Query: 915 YPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITK 974
+ R +++ + + V G+ + L+G +G GKST +++I PT G + L G
Sbjct: 1297 FSKRKNKIATRNVSFCVRKGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLLKGSGGGD 1356
Query: 975 SLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLP 1034
+L LG QE L+ N+ + + +V
Sbjct: 1357 ALEF------LGYCPQENALW-----PNLTVRQHLEVYAAVKGLRKGDAEVAITRLVDAL 1405
Query: 1035 KGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEAL 1090
K + K+++C +++ +P ++LLDE ++ +D ++ + +A+
Sbjct: 1406 K-LQDQLKSPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAI 1460
>X97187-1|CAA65825.1| 1704|Homo sapiens ABC-C transporter protein.
Length = 1704
Score = 77.4 bits (182), Expect = 3e-13
Identities = 55/202 (27%), Positives = 98/202 (48%), Gaps = 11/202 (5%)
Query: 924 LKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRK 983
++ ++L++ G+ L+G +G GK+T L ++ + PT+G + G +I++ + ++RK
Sbjct: 549 VRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMV--QIRK 606
Query: 984 QLGVVQQEPILFDR-TLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXX 1042
LG+ Q ILFD T+AE++ Y K + H I+ G E
Sbjct: 607 SLGLCPQHDILFDNLTVAEHL-YFYAQLKGLSRQKCPEEVKQMLH--II----GLEDKWN 659
Query: 1043 XXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITI 1102
++++ I ALI ++L+LDE TS +DA S RA+ + L RT +
Sbjct: 660 SRSRFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIVLT 719
Query: 1103 AHRLTTIK-DADIICVLDKGKI 1123
H + D I ++ KG++
Sbjct: 720 THFMDEADLLGDRIAIMAKGEL 741
Score = 73.7 bits (173), Expect = 3e-12
Identities = 59/240 (24%), Positives = 111/240 (46%), Gaps = 10/240 (4%)
Query: 311 DIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGW 370
D ++ +L++ G+ L+G +G GK+T L +L L+ P G + G + ++
Sbjct: 545 DRAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQ-DMVQ 603
Query: 371 LRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPN--GYETV 428
+R SLG+ Q +LF DN+ + + ++ E +K + + G E
Sbjct: 604 IRKSLGLCPQHDILF-----DNLTVAEHLYFYAQLKGLSRQKCPEE-VKQMLHIIGLEDK 657
Query: 429 IGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTL 488
R LSGG +++++I +L+ VL+LDE TS +D S + + L R RT +
Sbjct: 658 WNSRSRFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIV 717
Query: 489 TVSHRLSTI-VNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSGKETKEPEEIGTVL 547
+H + + RI M +G + G+ + L + G + + + PE+I ++
Sbjct: 718 LTTHFMDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTLVKEPHCNPEDISQLV 777
Score = 58.4 bits (135), Expect = 1e-07
Identities = 48/206 (23%), Positives = 89/206 (43%), Gaps = 7/206 (3%)
Query: 306 YPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKT 365
Y R + + SL ++ GE L+G +G GK+T ++L G + G + +
Sbjct: 1390 YEQRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVGGHRISS 1449
Query: 366 LNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGY 425
++G +R +G Q L + + Y + A ++ L
Sbjct: 1450 -DVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIG--ACVENTLRGLL--L 1504
Query: 426 ETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRA-SVG 484
E + + SGG K++++ +L+ EPAV+ LDE ++ +DP + + + + RA G
Sbjct: 1505 EPHANKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARESG 1564
Query: 485 RTTLTVSHRLSTI-VNCHRIICMDQG 509
+ + SH + C R+ M QG
Sbjct: 1565 KAIIITSHSMEECEALCTRLAIMVQG 1590
Score = 40.7 bits (91), Expect = 0.029
Identities = 38/210 (18%), Positives = 87/210 (41%), Gaps = 12/210 (5%)
Query: 908 INDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIEL 967
I ++ Y R + + + L V+ G+ L+G +G GK+T +++ T+G+ +
Sbjct: 1383 IKELSKVYEQRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFV 1442
Query: 968 DGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXH 1027
G I S + ++R+++G Q L D + + +
Sbjct: 1443 GGHRI--SSDVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTLR 1500
Query: 1028 NFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVT 1087
++ E + K+++ ALI P ++ LDE ++ +D + R +
Sbjct: 1501 GLLL------EPHANKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLW 1554
Query: 1088 EALDHAAK-GRTCITIAHRLTTIKDADIIC 1116
+ + A + G+ I +H ++++ + +C
Sbjct: 1555 DTVARARESGKAIIITSH---SMEECEALC 1581
>U78735-1|AAC50967.1| 1704|Homo sapiens ABC3 protein.
Length = 1704
Score = 77.4 bits (182), Expect = 3e-13
Identities = 55/202 (27%), Positives = 98/202 (48%), Gaps = 11/202 (5%)
Query: 924 LKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRK 983
++ ++L++ G+ L+G +G GK+T L ++ + PT+G + G +I++ + ++RK
Sbjct: 549 VRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMV--QIRK 606
Query: 984 QLGVVQQEPILFDR-TLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXX 1042
LG+ Q ILFD T+AE++ Y K + H I+ G E
Sbjct: 607 SLGLCPQHDILFDNLTVAEHL-YFYAQLKGLSRQKCPEEVKQMLH--II----GLEDKWN 659
Query: 1043 XXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITI 1102
++++ I ALI ++L+LDE TS +DA S RA+ + L RT +
Sbjct: 660 SRSRFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIVLT 719
Query: 1103 AHRLTTIK-DADIICVLDKGKI 1123
H + D I ++ KG++
Sbjct: 720 THFMDEADLLGDRIAIMAKGEL 741
Score = 73.7 bits (173), Expect = 3e-12
Identities = 59/240 (24%), Positives = 111/240 (46%), Gaps = 10/240 (4%)
Query: 311 DIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGW 370
D ++ +L++ G+ L+G +G GK+T L +L L+ P G + G + ++
Sbjct: 545 DRAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQ-DMVQ 603
Query: 371 LRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPN--GYETV 428
+R SLG+ Q +LF DN+ + + ++ E +K + + G E
Sbjct: 604 IRKSLGLCPQHDILF-----DNLTVAEHLYFYAQLKGLSRQKCPEE-VKQMLHIIGLEDK 657
Query: 429 IGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTL 488
R LSGG +++++I +L+ VL+LDE TS +D S + + L R RT +
Sbjct: 658 WNSRSRFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIV 717
Query: 489 TVSHRLSTI-VNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSGKETKEPEEIGTVL 547
+H + + RI M +G + G+ + L + G + + + PE+I ++
Sbjct: 718 LTTHFMDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTLVKEPHCNPEDISQLV 777
Score = 58.4 bits (135), Expect = 1e-07
Identities = 48/206 (23%), Positives = 89/206 (43%), Gaps = 7/206 (3%)
Query: 306 YPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKT 365
Y R + + SL ++ GE L+G +G GK+T ++L G + G + +
Sbjct: 1390 YEQRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVGGHRISS 1449
Query: 366 LNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGY 425
++G +R +G Q L + + Y + A ++ L
Sbjct: 1450 -DVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIG--ACVENTLRGLL--L 1504
Query: 426 ETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRA-SVG 484
E + + SGG K++++ +L+ EPAV+ LDE ++ +DP + + + + RA G
Sbjct: 1505 EPHANKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARESG 1564
Query: 485 RTTLTVSHRLSTI-VNCHRIICMDQG 509
+ + SH + C R+ M QG
Sbjct: 1565 KAIIITSHSMEECEALCTRLAIMVQG 1590
Score = 40.7 bits (91), Expect = 0.029
Identities = 38/210 (18%), Positives = 87/210 (41%), Gaps = 12/210 (5%)
Query: 908 INDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIEL 967
I ++ Y R + + + L V+ G+ L+G +G GK+T +++ T+G+ +
Sbjct: 1383 IKELSKVYEQRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFV 1442
Query: 968 DGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXH 1027
G I S + ++R+++G Q L D + + +
Sbjct: 1443 GGHRI--SSDVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTLR 1500
Query: 1028 NFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVT 1087
++ E + K+++ ALI P ++ LDE ++ +D + R +
Sbjct: 1501 GLLL------EPHANKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLW 1554
Query: 1088 EALDHAAK-GRTCITIAHRLTTIKDADIIC 1116
+ + A + G+ I +H ++++ + +C
Sbjct: 1555 DTVARARESGKAIIITSH---SMEECEALC 1581
>DQ073080-1|AAY57325.1| 1704|Homo sapiens ATP-binding cassette,
sub-family A (ABC1), member 3 protein.
Length = 1704
Score = 77.4 bits (182), Expect = 3e-13
Identities = 55/202 (27%), Positives = 98/202 (48%), Gaps = 11/202 (5%)
Query: 924 LKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRK 983
++ ++L++ G+ L+G +G GK+T L ++ + PT+G + G +I++ + ++RK
Sbjct: 549 VRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMV--QIRK 606
Query: 984 QLGVVQQEPILFDR-TLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXX 1042
LG+ Q ILFD T+AE++ Y K + H I+ G E
Sbjct: 607 SLGLCPQHDILFDNLTVAEHL-YFYAQLKGLSRQKCPEEVKQMLH--II----GLEDKWN 659
Query: 1043 XXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITI 1102
++++ I ALI ++L+LDE TS +DA S RA+ + L RT +
Sbjct: 660 SRSRFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIVLT 719
Query: 1103 AHRLTTIK-DADIICVLDKGKI 1123
H + D I ++ KG++
Sbjct: 720 THFMDEADLLGDRIAIMAKGEL 741
Score = 73.7 bits (173), Expect = 3e-12
Identities = 59/240 (24%), Positives = 111/240 (46%), Gaps = 10/240 (4%)
Query: 311 DIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGW 370
D ++ +L++ G+ L+G +G GK+T L +L L+ P G + G + ++
Sbjct: 545 DRAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQ-DMVQ 603
Query: 371 LRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPN--GYETV 428
+R SLG+ Q +LF DN+ + + ++ E +K + + G E
Sbjct: 604 IRKSLGLCPQHDILF-----DNLTVAEHLYFYAQLKGLSRQKCPEE-VKQMLHIIGLEDK 657
Query: 429 IGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTL 488
R LSGG +++++I +L+ VL+LDE TS +D S + + L R RT +
Sbjct: 658 WNSRSRFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIV 717
Query: 489 TVSHRLSTI-VNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSGKETKEPEEIGTVL 547
+H + + RI M +G + G+ + L + G + + + PE+I ++
Sbjct: 718 LTTHFMDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTLVKEPHCNPEDISQLV 777
Score = 58.4 bits (135), Expect = 1e-07
Identities = 48/206 (23%), Positives = 89/206 (43%), Gaps = 7/206 (3%)
Query: 306 YPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKT 365
Y R + + SL ++ GE L+G +G GK+T ++L G + G + +
Sbjct: 1390 YEQRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVGGHRISS 1449
Query: 366 LNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGY 425
++G +R +G Q L + + Y + A ++ L
Sbjct: 1450 -DVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIG--ACVENTLRGLL--L 1504
Query: 426 ETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRA-SVG 484
E + + SGG K++++ +L+ EPAV+ LDE ++ +DP + + + + RA G
Sbjct: 1505 EPHANKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARESG 1564
Query: 485 RTTLTVSHRLSTI-VNCHRIICMDQG 509
+ + SH + C R+ M QG
Sbjct: 1565 KAIIITSHSMEECEALCTRLAIMVQG 1590
Score = 40.7 bits (91), Expect = 0.029
Identities = 38/210 (18%), Positives = 87/210 (41%), Gaps = 12/210 (5%)
Query: 908 INDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIEL 967
I ++ Y R + + + L V+ G+ L+G +G GK+T +++ T+G+ +
Sbjct: 1383 IKELSKVYEQRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFV 1442
Query: 968 DGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXH 1027
G I S + ++R+++G Q L D + + +
Sbjct: 1443 GGHRI--SSDVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTLR 1500
Query: 1028 NFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVT 1087
++ E + K+++ ALI P ++ LDE ++ +D + R +
Sbjct: 1501 GLLL------EPHANKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLW 1554
Query: 1088 EALDHAAK-GRTCITIAHRLTTIKDADIIC 1116
+ + A + G+ I +H ++++ + +C
Sbjct: 1555 DTVARARESGKAIIITSH---SMEECEALC 1581
>AB210044-1|BAE06126.1| 1708|Homo sapiens ABCA3 variant protein
protein.
Length = 1708
Score = 77.4 bits (182), Expect = 3e-13
Identities = 55/202 (27%), Positives = 98/202 (48%), Gaps = 11/202 (5%)
Query: 924 LKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRK 983
++ ++L++ G+ L+G +G GK+T L ++ + PT+G + G +I++ + ++RK
Sbjct: 553 VRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMV--QIRK 610
Query: 984 QLGVVQQEPILFDR-TLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXX 1042
LG+ Q ILFD T+AE++ Y K + H I+ G E
Sbjct: 611 SLGLCPQHDILFDNLTVAEHL-YFYAQLKGLSRQKCPEEVKQMLH--II----GLEDKWN 663
Query: 1043 XXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITI 1102
++++ I ALI ++L+LDE TS +DA S RA+ + L RT +
Sbjct: 664 SRSRFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIVLT 723
Query: 1103 AHRLTTIK-DADIICVLDKGKI 1123
H + D I ++ KG++
Sbjct: 724 THFMDEADLLGDRIAIMAKGEL 745
Score = 73.7 bits (173), Expect = 3e-12
Identities = 59/240 (24%), Positives = 111/240 (46%), Gaps = 10/240 (4%)
Query: 311 DIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGW 370
D ++ +L++ G+ L+G +G GK+T L +L L+ P G + G + ++
Sbjct: 549 DRAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQ-DMVQ 607
Query: 371 LRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPN--GYETV 428
+R SLG+ Q +LF DN+ + + ++ E +K + + G E
Sbjct: 608 IRKSLGLCPQHDILF-----DNLTVAEHLYFYAQLKGLSRQKCPEE-VKQMLHIIGLEDK 661
Query: 429 IGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTL 488
R LSGG +++++I +L+ VL+LDE TS +D S + + L R RT +
Sbjct: 662 WNSRSRFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIV 721
Query: 489 TVSHRLSTI-VNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSGKETKEPEEIGTVL 547
+H + + RI M +G + G+ + L + G + + + PE+I ++
Sbjct: 722 LTTHFMDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTLVKEPHCNPEDISQLV 781
Score = 58.4 bits (135), Expect = 1e-07
Identities = 48/206 (23%), Positives = 89/206 (43%), Gaps = 7/206 (3%)
Query: 306 YPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKT 365
Y R + + SL ++ GE L+G +G GK+T ++L G + G + +
Sbjct: 1394 YEQRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVGGHRISS 1453
Query: 366 LNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGY 425
++G +R +G Q L + + Y + A ++ L
Sbjct: 1454 -DVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIG--ACVENTLRGLL--L 1508
Query: 426 ETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRA-SVG 484
E + + SGG K++++ +L+ EPAV+ LDE ++ +DP + + + + RA G
Sbjct: 1509 EPHANKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARESG 1568
Query: 485 RTTLTVSHRLSTI-VNCHRIICMDQG 509
+ + SH + C R+ M QG
Sbjct: 1569 KAIIITSHSMEECEALCTRLAIMVQG 1594
Score = 40.7 bits (91), Expect = 0.029
Identities = 38/210 (18%), Positives = 87/210 (41%), Gaps = 12/210 (5%)
Query: 908 INDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIEL 967
I ++ Y R + + + L V+ G+ L+G +G GK+T +++ T+G+ +
Sbjct: 1387 IKELSKVYEQRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFV 1446
Query: 968 DGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXH 1027
G I S + ++R+++G Q L D + + +
Sbjct: 1447 GGHRI--SSDVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTLR 1504
Query: 1028 NFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVT 1087
++ E + K+++ ALI P ++ LDE ++ +D + R +
Sbjct: 1505 GLLL------EPHANKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLW 1558
Query: 1088 EALDHAAK-GRTCITIAHRLTTIKDADIIC 1116
+ + A + G+ I +H ++++ + +C
Sbjct: 1559 DTVARARESGKAIIITSH---SMEECEALC 1585
>AB070929-1|BAB86781.1| 1704|Homo sapiens lamellar body membrane
specific ATP-binding cassette protein protein.
Length = 1704
Score = 77.4 bits (182), Expect = 3e-13
Identities = 55/202 (27%), Positives = 98/202 (48%), Gaps = 11/202 (5%)
Query: 924 LKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRK 983
++ ++L++ G+ L+G +G GK+T L ++ + PT+G + G +I++ + ++RK
Sbjct: 549 VRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMV--QIRK 606
Query: 984 QLGVVQQEPILFDR-TLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXX 1042
LG+ Q ILFD T+AE++ Y K + H I+ G E
Sbjct: 607 SLGLCPQHDILFDNLTVAEHL-YFYAQLKGLSRQKCPEEVKQMLH--II----GLEDKWN 659
Query: 1043 XXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITI 1102
++++ I ALI ++L+LDE TS +DA S RA+ + L RT +
Sbjct: 660 SRSRFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIVLT 719
Query: 1103 AHRLTTIK-DADIICVLDKGKI 1123
H + D I ++ KG++
Sbjct: 720 THFMDEADLLGDRIAIMAKGEL 741
Score = 73.7 bits (173), Expect = 3e-12
Identities = 59/240 (24%), Positives = 111/240 (46%), Gaps = 10/240 (4%)
Query: 311 DIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGW 370
D ++ +L++ G+ L+G +G GK+T L +L L+ P G + G + ++
Sbjct: 545 DRAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQ-DMVQ 603
Query: 371 LRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPN--GYETV 428
+R SLG+ Q +LF DN+ + + ++ E +K + + G E
Sbjct: 604 IRKSLGLCPQHDILF-----DNLTVAEHLYFYAQLKGLSRQKCPEE-VKQMLHIIGLEDK 657
Query: 429 IGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTL 488
R LSGG +++++I +L+ VL+LDE TS +D S + + L R RT +
Sbjct: 658 WNSRSRFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIV 717
Query: 489 TVSHRLSTI-VNCHRIICMDQGTIIEQGTHVELMKAKGFYHKLVTSGKETKEPEEIGTVL 547
+H + + RI M +G + G+ + L + G + + + PE+I ++
Sbjct: 718 LTTHFMDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTLVKEPHCNPEDISQLV 777
Score = 58.4 bits (135), Expect = 1e-07
Identities = 48/206 (23%), Positives = 89/206 (43%), Gaps = 7/206 (3%)
Query: 306 YPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKT 365
Y R + + SL ++ GE L+G +G GK+T ++L G + G + +
Sbjct: 1390 YEQRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVGGHRISS 1449
Query: 366 LNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGY 425
++G +R +G Q L + + Y + A ++ L
Sbjct: 1450 -DVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIG--ACVENTLRGLL--L 1504
Query: 426 ETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQVQAALDRA-SVG 484
E + + SGG K++++ +L+ EPAV+ LDE ++ +DP + + + + RA G
Sbjct: 1505 EPHANKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARESG 1564
Query: 485 RTTLTVSHRLSTI-VNCHRIICMDQG 509
+ + SH + C R+ M QG
Sbjct: 1565 KAIIITSHSMEECEALCTRLAIMVQG 1590
Score = 40.7 bits (91), Expect = 0.029
Identities = 38/210 (18%), Positives = 87/210 (41%), Gaps = 12/210 (5%)
Query: 908 INDVEFSYPTRAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIEL 967
I ++ Y R + + + L V+ G+ L+G +G GK+T +++ T+G+ +
Sbjct: 1383 IKELSKVYEQRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFV 1442
Query: 968 DGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTMDEXXXXXXXXXXH 1027
G I S + ++R+++G Q L D + + +
Sbjct: 1443 GGHRI--SSDVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTLR 1500
Query: 1028 NFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVT 1087
++ E + K+++ ALI P ++ LDE ++ +D + R +
Sbjct: 1501 GLLL------EPHANKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLW 1554
Query: 1088 EALDHAAK-GRTCITIAHRLTTIKDADIIC 1116
+ + A + G+ I +H ++++ + +C
Sbjct: 1555 DTVARARESGKAIIITSH---SMEECEALC 1581
>Y15635-1|CAA75729.1| 2273|Homo sapiens ABCR protein.
Length = 2273
Score = 77.0 bits (181), Expect = 4e-13
Identities = 58/210 (27%), Positives = 98/210 (46%), Gaps = 8/210 (3%)
Query: 329 ALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGT 388
A +G +G GK+T L +L L P G+V + GR+++T ++ +R SLG+ Q +LF
Sbjct: 960 AFLGHNGAGKTTTLSILTGLLPPTSGTVLVGGRDIET-SLDAVRQSLGMCPQHNILFHHL 1018
Query: 389 IYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIAR 448
+ Y + + E A G E LSGG ++++++A
Sbjct: 1019 TVAEHMLFYAQLKGKS----QEEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLSVAI 1074
Query: 449 SLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTI-VNCHRIICMD 507
+ + + V++LDE TS +DP+S + + L + GRT + +H + + RI +
Sbjct: 1075 AFVGDAKVVILDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRIAIIA 1134
Query: 508 QGTIIEQGTHVELMK--AKGFYHKLVTSGK 535
QG + GT + L G Y LV K
Sbjct: 1135 QGRLYCSGTPLFLKNCFGTGLYLTLVRKMK 1164
Score = 62.5 bits (145), Expect = 8e-09
Identities = 47/192 (24%), Positives = 86/192 (44%), Gaps = 11/192 (5%)
Query: 938 ALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDR 997
A +G +G GK+T L ++ PT+G + + G DI S L+ +R+ LG+ Q ILF
Sbjct: 960 AFLGHNGAGKTTTLSILTGLLPPTSGTVLVGGRDIETS--LDAVRQSLGMCPQHNILFHH 1017
Query: 998 -TLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRV 1056
T+AE++ + + + +E G ++++
Sbjct: 1018 LTVAEHMLFYAQLKGKSQEEAQLEMEAMLEDT-------GLHHKRNEEAQDLSGGMQRKL 1070
Query: 1057 CIARALIRSPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIK-DADII 1115
+A A + ++++LDE TS +D S R++ + L GRT I H + D I
Sbjct: 1071 SVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRI 1130
Query: 1116 CVLDKGKIVEKG 1127
++ +G++ G
Sbjct: 1131 AIIAQGRLYCSG 1142
Score = 60.5 bits (140), Expect = 3e-08
Identities = 52/208 (25%), Positives = 97/208 (46%), Gaps = 14/208 (6%)
Query: 322 IKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQE 381
++PGE L+G +G GK+T ++L G + G+++ T NI + ++G Q
Sbjct: 1962 VRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILT-NISEVHQNMGYCPQF 2020
Query: 382 PV---LFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSG 438
L G + + +E++ +VA + IK+L G + SG
Sbjct: 2021 DAIDELLTGREHLYLYARLRGVPAEEIEKVANWS-----IKSL--GLTVYADCLAGTYSG 2073
Query: 439 GQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-QAALDRASVGRTTLTVSHRLSTI 497
G K++++ A +L+ P ++LLDE T+ +DP + + + + GR + SH +
Sbjct: 2074 GNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSHSMEEC 2133
Query: 498 -VNCHRIICMDQGTIIEQGTHVELMKAK 524
C R+ M +G GT ++ +K+K
Sbjct: 2134 EALCTRLAIMVKGAFRCMGT-IQHLKSK 2160
Score = 34.7 bits (76), Expect = 1.9
Identities = 40/188 (21%), Positives = 79/188 (42%), Gaps = 14/188 (7%)
Query: 931 VEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQ 990
V G+ L+G +G GK+T +++ T+G+ + G I +++ + + +G Q
Sbjct: 1962 VRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNIS--EVHQNMGYCPQ 2019
Query: 991 EPILFDR-TLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXX 1049
+ + T E++ R +E I SL G
Sbjct: 2020 FDAIDELLTGREHLYLYARLRGVPAEEIEKVANWS-----IKSL--GLTVYADCLAGTYS 2072
Query: 1050 XXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEAL-DHAAKGRTCITIAHRLTT 1108
K+++ A ALI P L+LLDE T+ +D + R + + +GR + +H +
Sbjct: 2073 GGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSH---S 2129
Query: 1109 IKDADIIC 1116
+++ + +C
Sbjct: 2130 MEECEALC 2137
>U88667-1|AAC51144.1| 2273|Homo sapiens ATP-binding cassette
transporter protein.
Length = 2273
Score = 77.0 bits (181), Expect = 4e-13
Identities = 58/210 (27%), Positives = 98/210 (46%), Gaps = 8/210 (3%)
Query: 329 ALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGT 388
A +G +G GK+T L +L L P G+V + GR+++T ++ +R SLG+ Q +LF
Sbjct: 960 AFLGHNGAGKTTTLSILTGLLPPTSGTVLVGGRDIET-SLDAVRQSLGMCPQHNILFHHL 1018
Query: 389 IYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIAR 448
+ Y + + E A G E LSGG ++++++A
Sbjct: 1019 TVAEHMLFYAQLKGKS----QEEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLSVAI 1074
Query: 449 SLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTIVN-CHRIICMD 507
+ + + V++LDE TS +DP+S + + L + GRT + +H + + RI +
Sbjct: 1075 AFVGDAKVVILDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMPTHHMDEADHQGDRIAIIA 1134
Query: 508 QGTIIEQGTHVELMK--AKGFYHKLVTSGK 535
QG + GT + L G Y LV K
Sbjct: 1135 QGRLYCSGTPLFLKNCFGTGLYLTLVRKMK 1164
Score = 63.7 bits (148), Expect = 4e-09
Identities = 47/192 (24%), Positives = 86/192 (44%), Gaps = 11/192 (5%)
Query: 938 ALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDR 997
A +G +G GK+T L ++ PT+G + + G DI S L+ +R+ LG+ Q ILF
Sbjct: 960 AFLGHNGAGKTTTLSILTGLLPPTSGTVLVGGRDIETS--LDAVRQSLGMCPQHNILFHH 1017
Query: 998 -TLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRV 1056
T+AE++ + + + +E G ++++
Sbjct: 1018 LTVAEHMLFYAQLKGKSQEEAQLEMEAMLEDT-------GLHHKRNEEAQDLSGGMQRKL 1070
Query: 1057 CIARALIRSPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTI-KDADII 1115
+A A + ++++LDE TS +D S R++ + L GRT I H + D I
Sbjct: 1071 SVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMPTHHMDEADHQGDRI 1130
Query: 1116 CVLDKGKIVEKG 1127
++ +G++ G
Sbjct: 1131 AIIAQGRLYCSG 1142
Score = 60.5 bits (140), Expect = 3e-08
Identities = 52/208 (25%), Positives = 97/208 (46%), Gaps = 14/208 (6%)
Query: 322 IKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQE 381
++PGE L+G +G GK+T ++L G + G+++ T NI + ++G Q
Sbjct: 1962 VRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILT-NISEVHQNMGYCPQF 2020
Query: 382 PV---LFRGTIYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSG 438
L G + + +E++ +VA + IK+L G + SG
Sbjct: 2021 DAIDELLTGREHLYLYARLRGVPAEEIEKVANWS-----IKSL--GLTVYADCLAGTYSG 2073
Query: 439 GQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQV-QAALDRASVGRTTLTVSHRLSTI 497
G K++++ A +L+ P ++LLDE T+ +DP + + + + GR + SH +
Sbjct: 2074 GNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIRKGRAVVLTSHSMEEC 2133
Query: 498 -VNCHRIICMDQGTIIEQGTHVELMKAK 524
C R+ M +G GT ++ +K+K
Sbjct: 2134 EALCTRLAIMVKGAFRCMGT-IQHLKSK 2160
Score = 36.3 bits (80), Expect = 0.63
Identities = 41/188 (21%), Positives = 79/188 (42%), Gaps = 14/188 (7%)
Query: 931 VEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQ 990
V G+ L+G +G GK+T +++ T+G+ + G I +++ + + +G Q
Sbjct: 1962 VRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNIS--EVHQNMGYCPQ 2019
Query: 991 EPILFDR-TLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXX 1049
+ + T E++ R +E I SL G
Sbjct: 2020 FDAIDELLTGREHLYLYARLRGVPAEEIEKVANWS-----IKSL--GLTVYADCLAGTYS 2072
Query: 1050 XXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEAL-DHAAKGRTCITIAHRLTT 1108
K+++ A ALI P L+LLDE T+ +D + R + + KGR + +H +
Sbjct: 2073 GGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIRKGRAVVLTSH---S 2129
Query: 1109 IKDADIIC 1116
+++ + +C
Sbjct: 2130 MEECEALC 2137
>AF001945-1|AAC05632.1| 2273|Homo sapiens rim ABC transporter protein.
Length = 2273
Score = 77.0 bits (181), Expect = 4e-13
Identities = 58/210 (27%), Positives = 98/210 (46%), Gaps = 8/210 (3%)
Query: 329 ALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGT 388
A +G +G GK+T L +L L P G+V + GR+++T ++ +R SLG+ Q +LF
Sbjct: 960 AFLGHNGAGKTTTLSILTGLLPPTSGTVLVGGRDIET-SLDAVRQSLGMCPQHNILFHHL 1018
Query: 389 IYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIAR 448
+ Y + + E A G E LSGG ++++++A
Sbjct: 1019 TVAEHMLFYAQLKGKS----QEEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLSVAI 1074
Query: 449 SLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTI-VNCHRIICMD 507
+ + + V++LDE TS +DP+S + + L + GRT + +H + + RI +
Sbjct: 1075 AFVGDAKVVILDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRIAIIA 1134
Query: 508 QGTIIEQGTHVELMK--AKGFYHKLVTSGK 535
QG + GT + L G Y LV K
Sbjct: 1135 QGRLYCSGTPLFLKNCFGTGLYLTLVRKMK 1164
Score = 62.5 bits (145), Expect = 8e-09
Identities = 47/192 (24%), Positives = 86/192 (44%), Gaps = 11/192 (5%)
Query: 938 ALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDR 997
A +G +G GK+T L ++ PT+G + + G DI S L+ +R+ LG+ Q ILF
Sbjct: 960 AFLGHNGAGKTTTLSILTGLLPPTSGTVLVGGRDIETS--LDAVRQSLGMCPQHNILFHH 1017
Query: 998 -TLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRV 1056
T+AE++ + + + +E G ++++
Sbjct: 1018 LTVAEHMLFYAQLKGKSQEEAQLEMEAMLEDT-------GLHHKRNEEAQDLSGGMQRKL 1070
Query: 1057 CIARALIRSPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIK-DADII 1115
+A A + ++++LDE TS +D S R++ + L GRT I H + D I
Sbjct: 1071 SVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRI 1130
Query: 1116 CVLDKGKIVEKG 1127
++ +G++ G
Sbjct: 1131 AIIAQGRLYCSG 1142
Score = 61.3 bits (142), Expect = 2e-08
Identities = 56/233 (24%), Positives = 107/233 (45%), Gaps = 15/233 (6%)
Query: 297 ISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSV 356
+ L ++ YP S + + + ++PGE L+G +G GK+T ++L G
Sbjct: 1938 LRLHELTKIYPGTSSPAVDR-LCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDA 1996
Query: 357 KLDGRNLKTLNIGWLRSSLGVVGQEPV---LFRGTIYDNIAIGYPEATSEDVYRVAEMAY 413
+ G+++ T NI + ++G Q L G + + +E++ +VA +
Sbjct: 1997 TVAGKSILT-NISEVHQNMGYCPQFDAIDELLTGREHLYLYARLRGVPAEEIEKVANWS- 2054
Query: 414 AHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQ 473
IK+L G + SGG K++++ A +L+ P ++LLDE T+ +DP + +
Sbjct: 2055 ----IKSL--GLTVYADCLAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRM 2108
Query: 474 V-QAALDRASVGRTTLTVSHRLSTI-VNCHRIICMDQGTIIEQGTHVELMKAK 524
+ + GR + SH + C R+ M +G GT ++ +K+K
Sbjct: 2109 LWNVIVSIIREGRAVVLTSHSMEECEALCTRLAIMVKGAFRCMGT-IQHLKSK 2160
Score = 34.7 bits (76), Expect = 1.9
Identities = 40/188 (21%), Positives = 79/188 (42%), Gaps = 14/188 (7%)
Query: 931 VEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQ 990
V G+ L+G +G GK+T +++ T+G+ + G I +++ + + +G Q
Sbjct: 1962 VRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNIS--EVHQNMGYCPQ 2019
Query: 991 EPILFDR-TLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXX 1049
+ + T E++ R +E I SL G
Sbjct: 2020 FDAIDELLTGREHLYLYARLRGVPAEEIEKVANWS-----IKSL--GLTVYADCLAGTYS 2072
Query: 1050 XXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEAL-DHAAKGRTCITIAHRLTT 1108
K+++ A ALI P L+LLDE T+ +D + R + + +GR + +H +
Sbjct: 2073 GGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSH---S 2129
Query: 1109 IKDADIIC 1116
+++ + +C
Sbjct: 2130 MEECEALC 2137
>AF000148-1|AAC23915.1| 2273|Homo sapiens ATP-binding cassette
transporter protein.
Length = 2273
Score = 77.0 bits (181), Expect = 4e-13
Identities = 58/210 (27%), Positives = 98/210 (46%), Gaps = 8/210 (3%)
Query: 329 ALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGT 388
A +G +G GK+T L +L L P G+V + GR+++T ++ +R SLG+ Q +LF
Sbjct: 960 AFLGHNGAGKTTTLSILTGLLPPTSGTVLVGGRDIET-SLDAVRQSLGMCPQHNILFHHL 1018
Query: 389 IYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIAR 448
+ Y + + E A G E LSGG ++++++A
Sbjct: 1019 TVAEHMLFYAQLKGKS----QEEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLSVAI 1074
Query: 449 SLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTI-VNCHRIICMD 507
+ + + V++LDE TS +DP+S + + L + GRT + +H + + RI +
Sbjct: 1075 AFVGDAKVVILDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRIAIIA 1134
Query: 508 QGTIIEQGTHVELMK--AKGFYHKLVTSGK 535
QG + GT + L G Y LV K
Sbjct: 1135 QGRLYCSGTPLFLKNCFGTGLYLTLVRKMK 1164
Score = 62.5 bits (145), Expect = 8e-09
Identities = 47/192 (24%), Positives = 86/192 (44%), Gaps = 11/192 (5%)
Query: 938 ALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDR 997
A +G +G GK+T L ++ PT+G + + G DI S L+ +R+ LG+ Q ILF
Sbjct: 960 AFLGHNGAGKTTTLSILTGLLPPTSGTVLVGGRDIETS--LDAVRQSLGMCPQHNILFHH 1017
Query: 998 -TLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRV 1056
T+AE++ + + + +E G ++++
Sbjct: 1018 LTVAEHMLFYAQLKGKSQEEAQLEMEAMLEDT-------GLHHKRNEEAQDLSGGMQRKL 1070
Query: 1057 CIARALIRSPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIK-DADII 1115
+A A + ++++LDE TS +D S R++ + L GRT I H + D I
Sbjct: 1071 SVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRI 1130
Query: 1116 CVLDKGKIVEKG 1127
++ +G++ G
Sbjct: 1131 AIIAQGRLYCSG 1142
Score = 61.3 bits (142), Expect = 2e-08
Identities = 56/233 (24%), Positives = 107/233 (45%), Gaps = 15/233 (6%)
Query: 297 ISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSV 356
+ L ++ YP S + + + ++PGE L+G +G GK+T ++L G
Sbjct: 1938 LRLHELTKIYPGTSSPAVDR-LCVGVRPGECFGLLGVNGAGKTTTFKMLTGDNTVTSGDA 1996
Query: 357 KLDGRNLKTLNIGWLRSSLGVVGQEPV---LFRGTIYDNIAIGYPEATSEDVYRVAEMAY 413
+ G+++ T NI + ++G Q L G + + +E++ +VA +
Sbjct: 1997 TVAGKSILT-NISEVHQNMGYCPQFDAIDELLTGREHLYLYARLRGVPAEEIEKVANWS- 2054
Query: 414 AHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQ 473
IK+L G + SGG K++++ A +L+ P ++LLDE T+ +DP + +
Sbjct: 2055 ----IKSL--GLTVYADCLAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRM 2108
Query: 474 V-QAALDRASVGRTTLTVSHRLSTI-VNCHRIICMDQGTIIEQGTHVELMKAK 524
+ + GR + SH + C R+ M +G GT ++ +K+K
Sbjct: 2109 LWNVIVSIIREGRAVVLTSHSMEECEALCTRLAIMVKGAFRCMGT-IQHLKSK 2160
Score = 34.7 bits (76), Expect = 1.9
Identities = 40/188 (21%), Positives = 79/188 (42%), Gaps = 14/188 (7%)
Query: 931 VEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQ 990
V G+ L+G +G GK+T +++ T+G+ + G I +++ + + +G Q
Sbjct: 1962 VRPGECFGLLGVNGAGKTTTFKMLTGDNTVTSGDATVAGKSILTNIS--EVHQNMGYCPQ 2019
Query: 991 EPILFDR-TLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXX 1049
+ + T E++ R +E I SL G
Sbjct: 2020 FDAIDELLTGREHLYLYARLRGVPAEEIEKVANWS-----IKSL--GLTVYADCLAGTYS 2072
Query: 1050 XXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEAL-DHAAKGRTCITIAHRLTT 1108
K+++ A ALI P L+LLDE T+ +D + R + + +GR + +H +
Sbjct: 2073 GGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSH---S 2129
Query: 1109 IKDADIIC 1116
+++ + +C
Sbjct: 2130 MEECEALC 2137
>AB210040-1|BAE06122.1| 2303|Homo sapiens ABCA4 variant protein
protein.
Length = 2303
Score = 77.0 bits (181), Expect = 4e-13
Identities = 58/210 (27%), Positives = 98/210 (46%), Gaps = 8/210 (3%)
Query: 329 ALVGSSGCGKSTILQLLQRLYDPNQGSVKLDGRNLKTLNIGWLRSSLGVVGQEPVLFRGT 388
A +G +G GK+T L +L L P G+V + GR+++T ++ +R SLG+ Q +LF
Sbjct: 990 AFLGHNGAGKTTTLSILTGLLPPTSGTVLVGGRDIET-SLDAVRQSLGMCPQHNILFHHL 1048
Query: 389 IYDNIAIGYPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIAR 448
+ Y + + E A G E LSGG ++++++A
Sbjct: 1049 TVAEHMLFYAQLKGKS----QEEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLSVAI 1104
Query: 449 SLLREPAVLLLDEATSALDPHSEKQVQAALDRASVGRTTLTVSHRLSTI-VNCHRIICMD 507
+ + + V++LDE TS +DP+S + + L + GRT + +H + + RI +
Sbjct: 1105 AFVGDAKVVILDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRIAIIA 1164
Query: 508 QGTIIEQGTHVELMK--AKGFYHKLVTSGK 535
QG + GT + L G Y LV K
Sbjct: 1165 QGRLYCSGTPLFLKNCFGTGLYLTLVRKMK 1194
Score = 62.5 bits (145), Expect = 8e-09
Identities = 47/192 (24%), Positives = 86/192 (44%), Gaps = 11/192 (5%)
Query: 938 ALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDR 997
A +G +G GK+T L ++ PT+G + + G DI S L+ +R+ LG+ Q ILF
Sbjct: 990 AFLGHNGAGKTTTLSILTGLLPPTSGTVLVGGRDIETS--LDAVRQSLGMCPQHNILFHH 1047
Query: 998 -TLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRV 1056
T+AE++ + + + +E G ++++
Sbjct: 1048 LTVAEHMLFYAQLKGKSQEEAQLEMEAMLEDT-------GLHHKRNEEAQDLSGGMQRKL 1100
Query: 1057 CIARALIRSPRLLLLDEATSALDANSERAVTEALDHAAKGRTCITIAHRLTTIK-DADII 1115
+A A + ++++LDE TS +D S R++ + L GRT I H + D I
Sbjct: 1101 SVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRI 1160
Query: 1116 CVLDKGKIVEKG 1127
++ +G++ G
Sbjct: 1161 AIIAQGRLYCSG 1172
Score = 61.3 bits (142), Expect = 2e-08
Identities = 56/233 (24%), Positives = 107/233 (45%), Gaps = 15/233 (6%)
Query: 297 ISLEDVHFSYPSRSDIKILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPNQGSV 356
+ L ++ YP S + + + ++PGE L+G +G GK+T ++L G
Sbjct: 1968 LRLHELTKIYPGTSSPAVDR-LCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDA 2026
Query: 357 KLDGRNLKTLNIGWLRSSLGVVGQEPV---LFRGTIYDNIAIGYPEATSEDVYRVAEMAY 413
+ G+++ T NI + ++G Q L G + + +E++ +VA +
Sbjct: 2027 TVAGKSILT-NISEVHQNMGYCPQFDAIDELLTGREHLYLYARLRGVPAEEIEKVANWS- 2084
Query: 414 AHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEKQ 473
IK+L G + SGG K++++ A +L+ P ++LLDE T+ +DP + +
Sbjct: 2085 ----IKSL--GLTVYADCLAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRM 2138
Query: 474 V-QAALDRASVGRTTLTVSHRLSTI-VNCHRIICMDQGTIIEQGTHVELMKAK 524
+ + GR + SH + C R+ M +G GT ++ +K+K
Sbjct: 2139 LWNVIVSIIREGRAVVLTSHSMEECEALCTRLAIMVKGAFRCMGT-IQHLKSK 2190
Score = 34.7 bits (76), Expect = 1.9
Identities = 40/188 (21%), Positives = 79/188 (42%), Gaps = 14/188 (7%)
Query: 931 VEAGKTVALVGSSGCGKSTVLQLIQRFYDPTTGNIELDGVDITKSLTLNRLRKQLGVVQQ 990
V G+ L+G +G GK+T +++ T+G+ + G I +++ + + +G Q
Sbjct: 1992 VRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNIS--EVHQNMGYCPQ 2049
Query: 991 EPILFDR-TLAENIAYGDNSRKPTMDEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXX 1049
+ + T E++ R +E I SL G
Sbjct: 2050 FDAIDELLTGREHLYLYARLRGVPAEEIEKVANWS-----IKSL--GLTVYADCLAGTYS 2102
Query: 1050 XXXKQRVCIARALIRSPRLLLLDEATSALDANSERAVTEAL-DHAAKGRTCITIAHRLTT 1108
K+++ A ALI P L+LLDE T+ +D + R + + +GR + +H +
Sbjct: 2103 GGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSH---S 2159
Query: 1109 IKDADIIC 1116
+++ + +C
Sbjct: 2160 MEECEALC 2167
>X91249-1|CAA62631.1| 674|Homo sapiens white protein.
Length = 674
Score = 76.2 bits (179), Expect = 6e-13
Identities = 82/280 (29%), Positives = 133/280 (47%), Gaps = 25/280 (8%)
Query: 231 YIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKH-PKIDC-LSEA-- 286
+ +G ++ + T+ ++CV EV ++ A + LL+ H K+D L+EA
Sbjct: 4 FSVGTAMNASSYSAEMTEPKSVCVSVDEVVSSNMEATET--DLLNGHLKKVDNNLTEAQR 61
Query: 287 -GSSPRRVIGEISLEDVHFSYPS-----RSDIK-ILKGFSLHIKPGESVALVGSSGCGKS 339
S PRR I D+ +S P + K +LKG S GE VA++G SG GKS
Sbjct: 62 FSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKS 121
Query: 340 TILQLLQRLYDPN-QGSVKLDG--RNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIG 396
T++ +L + +G+V ++G R+L+ + S ++ + +L T+ + + +
Sbjct: 122 TLMNILAGYRETGMKGAVLINGLPRDLRCFR----KVSCYIMQDDMLLPHLTVQEAMMVS 177
Query: 397 YPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAV 456
E EM E + L G + R SLSGGQ++R+AIA L+ P V
Sbjct: 178 AHLKLQEKDEGRREMV--KEILTAL--GLLSCANTRTGSLSGGQRKRLAIALELVNNPPV 233
Query: 457 LLLDEATSALDPHSEKQVQAAL-DRASVGRTTLTVSHRLS 495
+ DE TS LD S QV + + A GR+ + H+ S
Sbjct: 234 MFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPS 273
Score = 55.6 bits (128), Expect = 1e-06
Identities = 56/242 (23%), Positives = 109/242 (45%), Gaps = 19/242 (7%)
Query: 902 ASGNFSINDVEFSYPT------RAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQ 955
A+ N D+ +S P + ++ +LKGI +G+ VA++G SG GKST++ ++
Sbjct: 69 AAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILA 128
Query: 956 RFYDP-TTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTM 1014
+ + G + ++G + + L R + ++Q + +L T+ E + + +
Sbjct: 129 GYRETGMKGAVLING--LPRDLRCFR-KVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEK 185
Query: 1015 DEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEA 1074
DE + +L G + ++R+ IA L+ +P ++ DE
Sbjct: 186 DE----GRREMVKEILTAL--GLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEP 239
Query: 1075 TSALDANSERAVTEALDHAAK-GRTCITIAHRLTT--IKDADIICVLDKGKIVEKGNHAE 1131
TS LD+ S V + A+ GR+ I H+ + + D + VL +G+ V +G
Sbjct: 240 TSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCN 299
Query: 1132 LI 1133
L+
Sbjct: 300 LV 301
>BC029158-1|AAH29158.2| 666|Homo sapiens ATP-binding cassette,
sub-family G (WHITE), member 1 protein.
Length = 666
Score = 76.2 bits (179), Expect = 6e-13
Identities = 82/280 (29%), Positives = 133/280 (47%), Gaps = 25/280 (8%)
Query: 231 YIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKH-PKIDC-LSEA-- 286
+ +G ++ + T+ ++CV EV ++ A + LL+ H K+D L+EA
Sbjct: 8 FSVGTAMNASSYSAEMTEPKSVCVSVDEVVSSNMEATET--DLLNGHLKKVDNNLTEAQR 65
Query: 287 -GSSPRRVIGEISLEDVHFSYPS-----RSDIK-ILKGFSLHIKPGESVALVGSSGCGKS 339
S PRR I D+ +S P + K +LKG S GE VA++G SG GKS
Sbjct: 66 FSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKS 125
Query: 340 TILQLLQRLYDPN-QGSVKLDG--RNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIG 396
T++ +L + +G+V ++G R+L+ + S ++ + +L T+ + + +
Sbjct: 126 TLMNILAGYRETGMKGAVLINGLPRDLRCFR----KVSCYIMQDDMLLPHLTVQEAMMVS 181
Query: 397 YPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAV 456
E EM E + L G + R SLSGGQ++R+AIA L+ P V
Sbjct: 182 AHLKLQEKDEGRREMV--KEILTAL--GLLSCANTRTGSLSGGQRKRLAIALELVNNPPV 237
Query: 457 LLLDEATSALDPHSEKQVQAAL-DRASVGRTTLTVSHRLS 495
+ DE TS LD S QV + + A GR+ + H+ S
Sbjct: 238 MFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPS 277
Score = 55.6 bits (128), Expect = 1e-06
Identities = 56/242 (23%), Positives = 109/242 (45%), Gaps = 19/242 (7%)
Query: 902 ASGNFSINDVEFSYPT------RAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQ 955
A+ N D+ +S P + ++ +LKGI +G+ VA++G SG GKST++ ++
Sbjct: 73 AAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILA 132
Query: 956 RFYDP-TTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTM 1014
+ + G + ++G + + L R + ++Q + +L T+ E + + +
Sbjct: 133 GYRETGMKGAVLING--LPRDLRCFR-KVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEK 189
Query: 1015 DEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEA 1074
DE + +L G + ++R+ IA L+ +P ++ DE
Sbjct: 190 DE----GRREMVKEILTAL--GLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEP 243
Query: 1075 TSALDANSERAVTEALDHAAK-GRTCITIAHRLTT--IKDADIICVLDKGKIVEKGNHAE 1131
TS LD+ S V + A+ GR+ I H+ + + D + VL +G+ V +G
Sbjct: 244 TSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCN 303
Query: 1132 LI 1133
L+
Sbjct: 304 LV 305
>AP001746-1|BAA95530.1| 674|Homo sapiens white protein homolog
(ATP-binding cassette transporter 8) protein.
Length = 674
Score = 76.2 bits (179), Expect = 6e-13
Identities = 82/280 (29%), Positives = 133/280 (47%), Gaps = 25/280 (8%)
Query: 231 YIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKH-PKIDC-LSEA-- 286
+ +G ++ + T+ ++CV EV ++ A + LL+ H K+D L+EA
Sbjct: 4 FSVGTAMNASSYSAEMTEPKSVCVSVDEVVSSNMEATET--DLLNGHLKKVDNNLTEAQR 61
Query: 287 -GSSPRRVIGEISLEDVHFSYPS-----RSDIK-ILKGFSLHIKPGESVALVGSSGCGKS 339
S PRR I D+ +S P + K +LKG S GE VA++G SG GKS
Sbjct: 62 FSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKS 121
Query: 340 TILQLLQRLYDPN-QGSVKLDG--RNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIG 396
T++ +L + +G+V ++G R+L+ + S ++ + +L T+ + + +
Sbjct: 122 TLMNILAGYRETGMKGAVLINGLPRDLRCFR----KVSCYIMQDDMLLPHLTVQEAMMVS 177
Query: 397 YPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAV 456
E EM E + L G + R SLSGGQ++R+AIA L+ P V
Sbjct: 178 AHLKLQEKDEGRREMV--KEILTAL--GLLSCANTRTGSLSGGQRKRLAIALELVNNPPV 233
Query: 457 LLLDEATSALDPHSEKQVQAAL-DRASVGRTTLTVSHRLS 495
+ DE TS LD S QV + + A GR+ + H+ S
Sbjct: 234 MFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPS 273
Score = 55.6 bits (128), Expect = 1e-06
Identities = 56/242 (23%), Positives = 109/242 (45%), Gaps = 19/242 (7%)
Query: 902 ASGNFSINDVEFSYPT------RAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQ 955
A+ N D+ +S P + ++ +LKGI +G+ VA++G SG GKST++ ++
Sbjct: 69 AAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILA 128
Query: 956 RFYDP-TTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTM 1014
+ + G + ++G + + L R + ++Q + +L T+ E + + +
Sbjct: 129 GYRETGMKGAVLING--LPRDLRCFR-KVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEK 185
Query: 1015 DEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEA 1074
DE + +L G + ++R+ IA L+ +P ++ DE
Sbjct: 186 DE----GRREMVKEILTAL--GLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEP 239
Query: 1075 TSALDANSERAVTEALDHAAK-GRTCITIAHRLTT--IKDADIICVLDKGKIVEKGNHAE 1131
TS LD+ S V + A+ GR+ I H+ + + D + VL +G+ V +G
Sbjct: 240 TSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCN 299
Query: 1132 LI 1133
L+
Sbjct: 300 LV 301
>AJ289137-1|CAC00730.1| 674|Homo sapiens ATP-binding cassette
transporter, sub-family G member 1 protein.
Length = 674
Score = 76.2 bits (179), Expect = 6e-13
Identities = 82/280 (29%), Positives = 133/280 (47%), Gaps = 25/280 (8%)
Query: 231 YIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKH-PKIDC-LSEA-- 286
+ +G ++ + T+ ++CV EV ++ A + LL+ H K+D L+EA
Sbjct: 4 FSVGTAMNASSYSAEMTEPKSVCVSVDEVVSSNMEATET--DLLNGHLKKVDNNLTEAQR 61
Query: 287 -GSSPRRVIGEISLEDVHFSYPS-----RSDIK-ILKGFSLHIKPGESVALVGSSGCGKS 339
S PRR I D+ +S P + K +LKG S GE VA++G SG GKS
Sbjct: 62 FSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKS 121
Query: 340 TILQLLQRLYDPN-QGSVKLDG--RNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIG 396
T++ +L + +G+V ++G R+L+ + S ++ + +L T+ + + +
Sbjct: 122 TLMNILAGYRETGMKGAVLINGLPRDLRCFR----KVSCYIMQDDMLLPHLTVQEAMMVS 177
Query: 397 YPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAV 456
E EM E + L G + R SLSGGQ++R+AIA L+ P V
Sbjct: 178 AHLKLQEKDEGRREMV--KEILTAL--GLLSCANTRTGSLSGGQRKRLAIALELVNNPPV 233
Query: 457 LLLDEATSALDPHSEKQVQAAL-DRASVGRTTLTVSHRLS 495
+ DE TS LD S QV + + A GR+ + H+ S
Sbjct: 234 MFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPS 273
Score = 55.6 bits (128), Expect = 1e-06
Identities = 56/242 (23%), Positives = 109/242 (45%), Gaps = 19/242 (7%)
Query: 902 ASGNFSINDVEFSYPT------RAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQ 955
A+ N D+ +S P + ++ +LKGI +G+ VA++G SG GKST++ ++
Sbjct: 69 AAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILA 128
Query: 956 RFYDP-TTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTM 1014
+ + G + ++G + + L R + ++Q + +L T+ E + + +
Sbjct: 129 GYRETGMKGAVLING--LPRDLRCFR-KVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEK 185
Query: 1015 DEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEA 1074
DE + +L G + ++R+ IA L+ +P ++ DE
Sbjct: 186 DE----GRREMVKEILTAL--GLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEP 239
Query: 1075 TSALDANSERAVTEALDHAAK-GRTCITIAHRLTT--IKDADIICVLDKGKIVEKGNHAE 1131
TS LD+ S V + A+ GR+ I H+ + + D + VL +G+ V +G
Sbjct: 240 TSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCN 299
Query: 1132 LI 1133
L+
Sbjct: 300 LV 301
>AF323658-3|AAK28837.1| 662|Homo sapiens ATP-binding cassette
transporter G1 variant IV protein.
Length = 662
Score = 76.2 bits (179), Expect = 6e-13
Identities = 82/280 (29%), Positives = 133/280 (47%), Gaps = 25/280 (8%)
Query: 231 YIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKH-PKIDC-LSEA-- 286
+ +G ++ + T+ ++CV EV ++ A + LL+ H K+D L+EA
Sbjct: 4 FSVGTAMNASSYSAEMTEPKSVCVSVDEVVSSNMEATET--DLLNGHLKKVDNNLTEAQR 61
Query: 287 -GSSPRRVIGEISLEDVHFSYPS-----RSDIK-ILKGFSLHIKPGESVALVGSSGCGKS 339
S PRR I D+ +S P + K +LKG S GE VA++G SG GKS
Sbjct: 62 FSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKS 121
Query: 340 TILQLLQRLYDPN-QGSVKLDG--RNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIG 396
T++ +L + +G+V ++G R+L+ + S ++ + +L T+ + + +
Sbjct: 122 TLMNILAGYRETGMKGAVLINGLPRDLRCFR----KVSCYIMQDDMLLPHLTVQEAMMVS 177
Query: 397 YPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAV 456
E EM E + L G + R SLSGGQ++R+AIA L+ P V
Sbjct: 178 AHLKLQEKDEGRREMV--KEILTAL--GLLSCANTRTGSLSGGQRKRLAIALELVNNPPV 233
Query: 457 LLLDEATSALDPHSEKQVQAAL-DRASVGRTTLTVSHRLS 495
+ DE TS LD S QV + + A GR+ + H+ S
Sbjct: 234 MFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPS 273
Score = 55.6 bits (128), Expect = 1e-06
Identities = 56/242 (23%), Positives = 109/242 (45%), Gaps = 19/242 (7%)
Query: 902 ASGNFSINDVEFSYPT------RAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQ 955
A+ N D+ +S P + ++ +LKGI +G+ VA++G SG GKST++ ++
Sbjct: 69 AAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILA 128
Query: 956 RFYDP-TTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTM 1014
+ + G + ++G + + L R + ++Q + +L T+ E + + +
Sbjct: 129 GYRETGMKGAVLING--LPRDLRCFR-KVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEK 185
Query: 1015 DEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEA 1074
DE + +L G + ++R+ IA L+ +P ++ DE
Sbjct: 186 DE----GRREMVKEILTAL--GLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEP 239
Query: 1075 TSALDANSERAVTEALDHAAK-GRTCITIAHRLTT--IKDADIICVLDKGKIVEKGNHAE 1131
TS LD+ S V + A+ GR+ I H+ + + D + VL +G+ V +G
Sbjct: 240 TSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCN 299
Query: 1132 LI 1133
L+
Sbjct: 300 LV 301
>AB038161-1|BAB13728.2| 674|Homo sapiens ABC transporter protein.
Length = 674
Score = 76.2 bits (179), Expect = 6e-13
Identities = 82/280 (29%), Positives = 133/280 (47%), Gaps = 25/280 (8%)
Query: 231 YIIGIVLSITFSVYMATQSITLCVPHMEVFATARGAAASIFSLLDKH-PKIDC-LSEA-- 286
+ +G ++ + T+ ++CV EV ++ A + LL+ H K+D L+EA
Sbjct: 4 FSVGTAMNASSYSAEMTEPKSVCVSVDEVVSSNMEATET--DLLNGHLKKVDNNLTEAQR 61
Query: 287 -GSSPRRVIGEISLEDVHFSYPS-----RSDIK-ILKGFSLHIKPGESVALVGSSGCGKS 339
S PRR I D+ +S P + K +LKG S GE VA++G SG GKS
Sbjct: 62 FSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKS 121
Query: 340 TILQLLQRLYDPN-QGSVKLDG--RNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIG 396
T++ +L + +G+V ++G R+L+ + S ++ + +L T+ + + +
Sbjct: 122 TLMNILAGYRETGMKGAVLINGLPRDLRCFR----KVSCYIMQDDMLLPHLTVQEAMMVS 177
Query: 397 YPEATSEDVYRVAEMAYAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAV 456
E EM E + L G + R SLSGGQ++R+AIA L+ P V
Sbjct: 178 AHLKLQEKDEGRREMV--KEILTAL--GLLSCANTRTGSLSGGQRKRLAIALELVNNPPV 233
Query: 457 LLLDEATSALDPHSEKQVQAAL-DRASVGRTTLTVSHRLS 495
+ DE TS LD S QV + + A GR+ + H+ S
Sbjct: 234 MFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPS 273
Score = 55.6 bits (128), Expect = 1e-06
Identities = 56/242 (23%), Positives = 109/242 (45%), Gaps = 19/242 (7%)
Query: 902 ASGNFSINDVEFSYPT------RAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQ 955
A+ N D+ +S P + ++ +LKGI +G+ VA++G SG GKST++ ++
Sbjct: 69 AAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILA 128
Query: 956 RFYDP-TTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTM 1014
+ + G + ++G + + L R + ++Q + +L T+ E + + +
Sbjct: 129 GYRETGMKGAVLING--LPRDLRCFR-KVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEK 185
Query: 1015 DEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEA 1074
DE + +L G + ++R+ IA L+ +P ++ DE
Sbjct: 186 DE----GRREMVKEILTAL--GLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEP 239
Query: 1075 TSALDANSERAVTEALDHAAK-GRTCITIAHRLTT--IKDADIICVLDKGKIVEKGNHAE 1131
TS LD+ S V + A+ GR+ I H+ + + D + VL +G+ V +G
Sbjct: 240 TSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCN 299
Query: 1132 LI 1133
L+
Sbjct: 300 LV 301
>AF323664-1|AAK28842.1| 677|Homo sapiens ATP-binding cassette
transporter G1 variant V protein.
Length = 677
Score = 75.8 bits (178), Expect = 8e-13
Identities = 81/264 (30%), Positives = 127/264 (48%), Gaps = 25/264 (9%)
Query: 247 TQSITLCVPHMEVFATARGAAASIFSLLDKH-PKIDC-LSEA---GSSPRRVIGEISLED 301
T+ ++CV EV ++ A + LL+ H K+D L+EA S PRR I D
Sbjct: 35 TEPKSVCVSVDEVVSSNMEATET--DLLNGHLKKVDNNLTEAQRFSSLPRRAAVNIEFRD 92
Query: 302 VHFSYPS-----RSDIK-ILKGFSLHIKPGESVALVGSSGCGKSTILQLLQRLYDPN-QG 354
+ +S P + K +LKG S GE VA++G SG GKST++ +L + +G
Sbjct: 93 LSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKG 152
Query: 355 SVKLDG--RNLKTLNIGWLRSSLGVVGQEPVLFRGTIYDNIAIGYPEATSEDVYRVAEMA 412
+V ++G R+L+ + S ++ + +L T+ + + + E EM
Sbjct: 153 AVLINGLPRDLRCFR----KVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMV 208
Query: 413 YAHEFIKNLPNGYETVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSEK 472
E + L G + R SLSGGQ++R+AIA L+ P V+ DE TS LD S
Sbjct: 209 --KEILTAL--GLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCF 264
Query: 473 QVQAAL-DRASVGRTTLTVSHRLS 495
QV + + A GR+ + H+ S
Sbjct: 265 QVVSLMKGLAQGGRSIICTIHQPS 288
Score = 55.6 bits (128), Expect = 1e-06
Identities = 56/242 (23%), Positives = 109/242 (45%), Gaps = 19/242 (7%)
Query: 902 ASGNFSINDVEFSYPT------RAHQMILKGIDLHVEAGKTVALVGSSGCGKSTVLQLIQ 955
A+ N D+ +S P + ++ +LKGI +G+ VA++G SG GKST++ ++
Sbjct: 84 AAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILA 143
Query: 956 RFYDP-TTGNIELDGVDITKSLTLNRLRKQLGVVQQEPILFDRTLAENIAYGDNSRKPTM 1014
+ + G + ++G + + L R + ++Q + +L T+ E + + +
Sbjct: 144 GYRETGMKGAVLING--LPRDLRCFR-KVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEK 200
Query: 1015 DEXXXXXXXXXXHNFIVSLPKGYETNXXXXXXXXXXXXKQRVCIARALIRSPRLLLLDEA 1074
DE + +L G + ++R+ IA L+ +P ++ DE
Sbjct: 201 DE----GRREMVKEILTAL--GLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEP 254
Query: 1075 TSALDANSERAVTEALDHAAK-GRTCITIAHRLTT--IKDADIICVLDKGKIVEKGNHAE 1131
TS LD+ S V + A+ GR+ I H+ + + D + VL +G+ V +G
Sbjct: 255 TSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCN 314
Query: 1132 LI 1133
L+
Sbjct: 315 LV 316
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.319 0.134 0.386
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 147,877,576
Number of Sequences: 224733
Number of extensions: 5834129
Number of successful extensions: 19326
Number of sequences better than 10.0: 443
Number of HSP's better than 10.0 without gapping: 432
Number of HSP's successfully gapped in prelim test: 11
Number of HSP's that attempted gapping in prelim test: 16079
Number of HSP's gapped (non-prelim): 1984
length of query: 1149
length of database: 73,234,838
effective HSP length: 98
effective length of query: 1051
effective length of database: 51,211,004
effective search space: 53822765204
effective search space used: 53822765204
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.8 bits)
S2: 71 (32.7 bits)
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