Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA000724-TA|BGIBMGA000724-PA|IPR003439|ABC transporter
related, IPR011527|ABC transporter, transmembrane region, type 1,
IPR005829|Sugar transporter superfamily, IPR003593|AAA ATPase,
IPR001140|ABC transporter, transmembrane region
(1258 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
M29447-1|AAA59576.1| 1280|Homo sapiens P glycoprotein protein. 775 0.0
AY910577-1|AAW82430.1| 1280|Homo sapiens ATP-binding cassette, s... 775 0.0
BC130424-1|AAI30425.1| 1280|Homo sapiens ATP-binding cassette, s... 774 0.0
M14758-1|AAA59575.1| 1280|Homo sapiens PGY1 protein. 772 0.0
AF016535-1|AAB69423.1| 1279|Homo sapiens P-glycoprotein protein. 771 0.0
AB208970-1|BAD92207.1| 1062|Homo sapiens Multidrug resistance pr... 701 0.0
M23234-1|AAA36207.1| 1279|Homo sapiens protein ( Human membrane ... 448 e-125
EF034088-1|ABJ53424.1| 1286|Homo sapiens ATP-binding cassette, s... 448 e-125
BC042531-1|AAH42531.1| 1286|Homo sapiens ATP-binding cassette, s... 446 e-124
AF136523-1|AAD28285.1| 1321|Homo sapiens bile salt export pump p... 408 e-113
AF091582-1|AAC77455.1| 1321|Homo sapiens bile salt export pump p... 408 e-113
AC008177-1|AAY24305.1| 870|Homo sapiens unknown protein. 408 e-113
BC104920-1|AAI04921.1| 812|Homo sapiens ATP-binding cassette, s... 335 5e-91
BC104894-1|AAI04895.2| 812|Homo sapiens ATP-binding cassette, s... 335 5e-91
AY234788-1|AAO73470.1| 812|Homo sapiens P-glycoprotein ABCB5 pr... 335 7e-91
AY090613-1|AAM09027.1| 812|Homo sapiens P-glycoprotein protein. 335 7e-91
AF399931-1|AAQ03033.1| 832|Homo sapiens P-glycoprotein protein. 335 7e-91
AF319622-1|AAN76500.1| 681|Homo sapiens P-glycoprotein protein. 335 7e-91
AY851365-1|AAW31630.1| 812|Homo sapiens ABCB5beta protein. 332 5e-90
AC069137-4|AAY24100.1| 451|Homo sapiens unknown protein. 313 2e-84
BC064930-1|AAH64930.1| 738|Homo sapiens ATP-binding cassette, s... 304 1e-81
AL121990-4|CAI22012.1| 738|Homo sapiens ATP-binding cassette, s... 304 1e-81
AF216833-1|AAF78198.1| 738|Homo sapiens M-ABC2 protein protein. 301 7e-81
AK094636-1|BAC04392.1| 701|Homo sapiens protein ( Homo sapiens ... 301 1e-80
BC141814-1|AAI41815.1| 718|Homo sapiens ATP-binding cassette, s... 300 2e-80
AK222911-1|BAD96631.1| 718|Homo sapiens ATP-binding cassette, s... 300 2e-80
AK002018-1|BAA92038.1| 735|Homo sapiens protein ( Homo sapiens ... 300 2e-80
X06181-1|CAA29547.1| 431|Homo sapiens P-glycoprotein (431 AA) p... 297 2e-79
AF047690-1|AAD15748.1| 718|Homo sapiens ATP-binding cassette pr... 297 2e-79
AB013380-1|BAB20265.1| 737|Homo sapiens mono ATP-binding casset... 291 1e-77
AK172794-1|BAD18770.1| 433|Homo sapiens protein ( Homo sapiens ... 281 8e-75
AF216494-1|AAF89993.1| 766|Homo sapiens ATP-binding cassette pr... 263 2e-69
AB177852-1|BAD66830.1| 796|Homo sapiens KIAA1520 splice variant... 263 2e-69
AB045381-1|BAA97989.2| 766|Homo sapiens TAPL protein. 263 2e-69
AB040953-1|BAA96044.2| 810|Homo sapiens KIAA1520 protein protein. 263 2e-69
BC141836-1|AAI41837.1| 693|Homo sapiens Unknown (protein for MG... 263 3e-69
BC064384-1|AAH64384.1| 769|Homo sapiens ABCB9 protein protein. 260 2e-68
AC006154-1|AAD05023.1| 407|Homo sapiens unknown protein. 255 8e-67
AK074738-1|BAC11171.1| 472|Homo sapiens protein ( Homo sapiens ... 248 1e-64
AY523970-1|AAS55411.1| 748|Homo sapiens TAP1 protein. 248 1e-64
L21206-1|AAC12904.1| 748|Homo sapiens peptide transporter protein. 246 3e-64
L21205-1|AAC12903.1| 748|Homo sapiens peptide transporter protein. 246 3e-64
AY523971-1|AAS55412.1| 748|Homo sapiens TAP1 protein. 246 3e-64
L21207-1|AAC12905.1| 748|Homo sapiens peptide transporter protein. 246 5e-64
L21208-1|AAC12906.1| 748|Homo sapiens peptide transporter protein. 244 2e-63
X87344-5|CAA60785.1| 748|Homo sapiens TAP1 protein. 243 3e-63
X66401-2|CAA47025.1| 748|Homo sapiens ABC-transporter protein. 243 3e-63
X57522-1|CAA40741.1| 808|Homo sapiens peptide transporter protein. 243 3e-63
L21204-1|AAC12902.1| 748|Homo sapiens peptide transporter protein. 243 3e-63
BX088556-4|CAM26263.1| 808|Homo sapiens transporter 1 ATP-bindi... 243 3e-63
BC014081-1|AAH14081.1| 808|Homo sapiens transporter 1, ATP-bind... 243 3e-63
AL935043-6|CAI18626.1| 808|Homo sapiens transporter 1, ATP-bind... 243 3e-63
AL671681-12|CAI17714.1| 808|Homo sapiens transporter 1, ATP-bin... 243 3e-63
AL669918-8|CAI18140.1| 808|Homo sapiens transporter 1, ATP-bind... 243 3e-63
X87344-8|CAA60788.1| 686|Homo sapiens TAP2 protein. 227 1e-58
X66401-4|CAA47027.1| 686|Homo sapiens TAP2 protein. 227 1e-58
U07844-1|AAA79901.1| 622|Homo sapiens ABC transport protein pro... 227 1e-58
BT009906-1|AAP88908.1| 686|Homo sapiens transporter 2, ATP-bind... 227 1e-58
AL935043-2|CAI18622.1| 686|Homo sapiens transporter 2, ATP-bind... 227 1e-58
AL671681-8|CAI17711.1| 686|Homo sapiens transporter 2, ATP-bind... 227 1e-58
AL669918-4|CAI18137.1| 686|Homo sapiens transporter 2, ATP-bind... 227 1e-58
M74447-1|AAA59841.1| 703|Homo sapiens PSF-2 protein. 227 2e-58
Z22935-1|CAA80522.1| 703|Homo sapiens TAP2B protein. 227 3e-58
BX682530-4|CAI41935.1| 703|Homo sapiens transporter 2 ATP-bindi... 227 3e-58
AK222823-1|BAD96543.1| 703|Homo sapiens transporter 2, ATP-bind... 227 3e-58
AF100418-1|AAD23381.1| 483|Homo sapiens TAP2 protein protein. 227 3e-58
AB208953-1|BAD92190.1| 704|Homo sapiens transporter 2, ATP-bind... 227 3e-58
Z22936-1|CAA80523.1| 686|Homo sapiens TAP2E protein. 226 4e-58
AB073779-1|BAB71769.1| 703|Homo sapiens ABC-transporter protein. 226 4e-58
AF136750-1|AAD23601.1| 483|Homo sapiens TAP2 protein protein. 225 1e-57
BC000559-1|AAH00559.1| 842|Homo sapiens ATP-binding cassette, s... 224 1e-57
AK057026-1|BAB71347.1| 766|Homo sapiens protein ( Homo sapiens ... 224 1e-57
AJ289233-1|CAB95766.2| 842|Homo sapiens ABC transporter umat pr... 224 1e-57
AF308472-1|AAG33617.1| 896|Homo sapiens ATP-binding cassette ha... 224 1e-57
AF076775-1|AAF75107.1| 842|Homo sapiens MT-ABC transporter prot... 224 1e-57
AF070598-1|AAC28653.1| 511|Homo sapiens ABC transporter protein. 224 1e-57
AB039371-1|BAA96733.1| 842|Homo sapiens mitochondrial ABC trans... 224 1e-57
BC043423-1|AAH43423.1| 301|Homo sapiens ABCB6 protein protein. 221 1e-56
AK223300-1|BAD97020.1| 703|Homo sapiens transporter 2, ATP-bind... 219 7e-56
AK172812-1|BAD18782.1| 571|Homo sapiens protein ( Homo sapiens ... 218 9e-56
BT009918-1|AAP88920.1| 753|Homo sapiens ATP-binding cassette, s... 218 1e-55
BC006323-1|AAH06323.1| 753|Homo sapiens ATP-binding cassette, s... 218 1e-55
AL360179-2|CAH70565.1| 752|Homo sapiens ATP-binding cassette, s... 218 1e-55
AL360179-1|CAH70564.1| 753|Homo sapiens ATP-binding cassette, s... 218 1e-55
AL359545-2|CAI41573.1| 752|Homo sapiens ATP-binding cassette, s... 218 1e-55
AL359545-1|CAI41574.1| 753|Homo sapiens ATP-binding cassette, s... 218 1e-55
AF241887-1|AAK20173.1| 752|Homo sapiens ATP binding cassette 7 ... 218 1e-55
AF133659-1|AAD33045.1| 752|Homo sapiens ATP-binding cassette 7 ... 218 1e-55
AF078777-1|AAD47141.1| 748|Homo sapiens ABC transporter protein. 217 2e-55
AB112583-1|BAC98410.1| 681|Homo sapiens TAP-Like isoform 12C pr... 216 5e-55
AB112582-1|BAC98409.1| 683|Homo sapiens TAP-Like isoform 12B pr... 216 5e-55
AB005289-1|BAA28861.1| 752|Homo sapiens ABC transporter 7 prote... 214 1e-54
U18237-1|AAA84438.1| 229|Homo sapiens ATP-binding cassette prot... 212 8e-54
AF176984-1|AAD50509.1| 372|Homo sapiens TAP2 protein protein. 211 1e-53
AF105151-1|AAD12059.1| 653|Homo sapiens Tap2 transporter isofor... 209 5e-53
BX682530-5|CAI41936.1| 653|Homo sapiens transporter 2 ATP-bindi... 208 7e-53
BX296564-5|CAI41937.1| 653|Homo sapiens transporter 2 ATP-bindi... 208 7e-53
AL935043-1|CAI18621.1| 653|Homo sapiens transporter 2, ATP-bind... 208 7e-53
AL671681-7|CAI17710.1| 653|Homo sapiens transporter 2, ATP-bind... 208 7e-53
AL669918-3|CAI18136.1| 653|Homo sapiens transporter 2, ATP-bind... 208 7e-53
AF078671-1|AAD31384.1| 653|Homo sapiens transporter 2 isoform p... 208 7e-53
AF087138-1|AAC36724.1| 1581|Homo sapiens sulfonylurea receptor 1... 145 8e-34
L78243-2|AAB02418.1| 1582|Homo sapiens SUR1 protein. 144 2e-33
L78243-1|AAB02417.1| 1581|Homo sapiens SUR1 protein. 144 2e-33
L78207-1|AAB02278.1| 1581|Homo sapiens sulfonylurea receptor pro... 144 2e-33
Y17151-1|CAA76658.2| 1527|Homo sapiens multidrug resistance prot... 144 2e-33
AF104943-1|AAD04170.1| 1527|Homo sapiens ABC transporter MOAT-D ... 144 2e-33
AF085690-1|AAD02845.1| 1527|Homo sapiens multidrug resistance-as... 144 2e-33
AF009670-1|AAD01430.1| 1528|Homo sapiens MRP3 protein. 144 2e-33
AB010887-1|BAA28146.1| 1527|Homo sapiens multidrug resistance-as... 144 2e-33
AF154001-1|AAD38185.1| 285|Homo sapiens MRP3s1 protein protein. 143 4e-33
AB208954-1|BAD92191.1| 1533|Homo sapiens ATP-binding cassette, s... 143 4e-33
U63455-1|AAB36700.1| 1581|Homo sapiens sulfonylurea receptor pro... 142 5e-33
U63421-1|AAB36699.1| 1581|Homo sapiens sulfonylurea receptor pro... 142 5e-33
AF083552-1|AAC34668.1| 1527|Homo sapiens canalicular multispecif... 142 5e-33
L05628-1|AAB46616.1| 1531|Homo sapiens multidrug resistance-asso... 142 7e-33
EF419769-1|ABN79590.1| 1531|Homo sapiens ATP-binding cassette, s... 142 7e-33
AF022853-5|AAB83982.1| 1400|Homo sapiens multidrug resistance pr... 142 7e-33
AF022853-4|AAB83981.1| 1456|Homo sapiens multidrug resistance pr... 142 7e-33
AF022853-3|AAB83980.1| 1459|Homo sapiens multidrug resistance pr... 142 7e-33
AF022853-1|AAB83979.1| 1515|Homo sapiens multidrug resistance pr... 142 7e-33
AB209120-1|BAD92357.1| 1439|Homo sapiens ATP-binding cassette, s... 142 7e-33
U49248-1|AAB09422.1| 1545|Homo sapiens canalicular multispecific... 142 9e-33
X96395-1|CAA65259.2| 1545|Homo sapiens canalicular multidrug res... 140 4e-32
U63970-1|AAB39892.1| 1545|Homo sapiens canalicular multispecific... 140 4e-32
AL392107-3|CAI11010.1| 1545|Homo sapiens ATP-binding cassette, s... 140 4e-32
AL133353-7|CAI14502.1| 1545|Homo sapiens ATP-binding cassette, s... 140 4e-32
AL833963-1|CAD38811.1| 453|Homo sapiens hypothetical protein pr... 139 5e-32
AF061324-1|AAC16058.1| 1549|Homo sapiens sulfonylurea receptor 2... 138 1e-31
AJ132244-1|CAB45309.1| 1545|Homo sapiens multidrug resistance pr... 137 3e-31
X95715-1|CAA65019.1| 453|Homo sapiens anthracycline resistance ... 136 4e-31
U91318-1|AAC15784.1| 401|Homo sapiens Multiple drug resistance ... 136 4e-31
U83659-1|AAB71756.1| 485|Homo sapiens multidrug resistance-asso... 136 4e-31
BC001636-1|AAH01636.1| 316|Homo sapiens Unknown (protein for IM... 136 4e-31
AF168791-1|AAD51293.1| 1503|Homo sapiens multi-specific organic ... 136 4e-31
BC131732-1|AAI31733.1| 1503|Homo sapiens ATP-binding cassette, s... 136 5e-31
BC024103-1|AAH24103.1| 282|Homo sapiens ABCC10 protein protein. 136 5e-31
AL359813-2|CAI23217.1| 1492|Homo sapiens ATP-binding cassette, s... 136 5e-31
AL133613-1|CAB63742.1| 700|Homo sapiens hypothetical protein pr... 136 5e-31
AK024446-1|BAB15736.1| 706|Homo sapiens FLJ00036 protein protein. 136 5e-31
AK000002-1|BAA92227.1| 1513|Homo sapiens FLJ00002 protein protein. 136 5e-31
AF076622-1|AAC79696.1| 1503|Homo sapiens MRP6 protein. 136 5e-31
AF061323-1|AAC16057.1| 1549|Homo sapiens sulfonylurea receptor 2... 135 8e-31
U83661-1|AAB71758.2| 1437|Homo sapiens multidrug resistance prot... 134 2e-30
AY032599-1|AAK39642.1| 1463|Homo sapiens multidrug resistance-as... 134 2e-30
AF146074-1|AAD37716.1| 1437|Homo sapiens ABC protein protein. 134 2e-30
AF104942-1|AAD04169.1| 1437|Homo sapiens ABC transporter MOAT-C ... 134 2e-30
AB209454-1|BAD92691.1| 1430|Homo sapiens Multidrug resistance-as... 134 2e-30
AY207008-1|AAO37649.1| 1325|Homo sapiens ATP-binding cassette tr... 133 4e-30
AY196484-1|AAO49801.1| 1394|Homo sapiens ATP-binding cassette C5... 133 4e-30
AY081219-1|AAL88745.1| 1325|Homo sapiens multidrug resistance-as... 133 4e-30
AY040220-1|AAK76740.1| 1359|Homo sapiens ATP-binding cassette tr... 133 4e-30
AL356257-1|CAI16722.1| 1325|Homo sapiens ATP-binding cassette, s... 133 4e-30
AL157818-1|CAC36037.2| 1325|Homo sapiens ATP-binding cassette, s... 133 4e-30
AL139381-1|CAI16589.1| 1325|Homo sapiens ATP-binding cassette, s... 133 4e-30
AF541977-1|AAN17334.1| 1278|Homo sapiens ATP-binding cassette pr... 133 4e-30
AF071203-1|AAC27077.1| 893|Homo sapiens ABC transporter MOAT-B ... 133 4e-30
AF071202-1|AAC27076.1| 1325|Homo sapiens ABC transporter MOAT-B ... 133 4e-30
AB019002-1|BAA76608.1| 1437|Homo sapiens MRP5 protein. 132 8e-30
AB005659-1|BAA22887.1| 946|Homo sapiens SMRP protein. 132 8e-30
AY851364-1|AAW31629.1| 131|Homo sapiens ABCB5alpha protein. 131 2e-29
AF352582-1|AAK19755.1| 1382|Homo sapiens ATP-binding cassette tr... 131 2e-29
AY040219-1|AAK76739.1| 1382|Homo sapiens ATP-binding cassette tr... 129 7e-29
AF367202-1|AAK58869.1| 1382|Homo sapiens ATP-binding cassette pr... 129 7e-29
BC017348-1|AAH17348.1| 596|Homo sapiens ABCB9 protein protein. 126 5e-28
L40625-1|AAA99227.1| 395|Homo sapiens sulfonylurea receptor pro... 124 2e-27
AY490254-1|AAR99172.1| 164|Homo sapiens P-glycoprotein protein. 124 2e-27
AJ294545-1|CAC69553.1| 1514|Homo sapiens multidrug resistance as... 124 2e-27
AL122095-1|CAB59263.1| 216|Homo sapiens hypothetical protein pr... 121 1e-26
AF022853-2|AAB83983.1| 1450|Homo sapiens multidrug resistance pr... 119 6e-26
AY196326-1|AAO40749.1| 930|Homo sapiens truncated ABCC12 protei... 119 8e-26
AF411578-1|AAL99901.1| 1009|Homo sapiens ATP-binding cassette pr... 119 8e-26
AF411577-1|AAL99900.1| 1009|Homo sapiens ATP-binding cassette pr... 119 8e-26
AF395909-1|AAL79529.1| 935|Homo sapiens ATP-binding cassette pr... 119 8e-26
AF395908-1|AAL79528.1| 1009|Homo sapiens ATP-binding cassette pr... 119 8e-26
AB208973-1|BAD92210.1| 776|Homo sapiens ABCC4 protein variant p... 115 9e-25
AB209103-1|BAD92340.1| 799|Homo sapiens ATP-binding cassette C5... 114 2e-24
BC041560-1|AAH41560.1| 859|Homo sapiens ABCC4 protein protein. 113 3e-24
L09191-1|AAA58648.1| 129|Homo sapiens TAP2 protein. 113 4e-24
L10287-1|AAA58649.1| 129|Homo sapiens TAP2 protein. 111 1e-23
AF411579-1|AAL99902.1| 1344|Homo sapiens ATP-binding cassette pr... 107 2e-22
AB209084-1|BAD92321.1| 1011|Homo sapiens Sulfonylurea receptor 1... 106 4e-22
AC003026-1|AAC05808.1| 691|Homo sapiens Multiple drug resistanc... 103 3e-21
X57521-1|CAA40740.1| 430|Homo sapiens Y3 protein. 103 4e-21
U91318-3|AAC15785.1| 848|Homo sapiens Gene product with similar... 101 1e-20
M55131-1|AAC13657.1| 1480|Homo sapiens cystic fibrosis transmemb... 100 4e-20
M28668-1|AAA35680.1| 1480|Homo sapiens protein ( Human cystic fi... 100 4e-20
DQ388145-1|ABD72217.1| 1480|Homo sapiens cystic fibrosis transme... 100 4e-20
DQ388143-1|ABD72213.1| 1480|Homo sapiens cystic fibrosis transme... 100 4e-20
DQ388142-1|ABD72211.1| 1480|Homo sapiens cystic fibrosis transme... 100 4e-20
DQ388141-1|ABD72209.1| 1480|Homo sapiens cystic fibrosis transme... 100 4e-20
DQ388140-1|ABD72207.1| 1480|Homo sapiens cystic fibrosis transme... 100 4e-20
DQ388139-1|ABD72205.1| 1480|Homo sapiens cystic fibrosis transme... 100 4e-20
DQ388138-1|ABD72203.1| 1480|Homo sapiens cystic fibrosis transme... 100 4e-20
DQ388137-1|ABD72201.1| 1480|Homo sapiens cystic fibrosis transme... 100 4e-20
DQ388135-1|ABD72197.1| 1480|Homo sapiens cystic fibrosis transme... 100 4e-20
DQ388134-1|ABD72195.1| 1480|Homo sapiens cystic fibrosis transme... 100 4e-20
DQ388133-1|ABD72193.1| 1480|Homo sapiens cystic fibrosis transme... 100 4e-20
DQ388132-1|ABD72191.1| 1480|Homo sapiens cystic fibrosis transme... 100 4e-20
DQ388131-1|ABD72189.1| 1480|Homo sapiens cystic fibrosis transme... 100 4e-20
DQ388130-1|ABD72187.1| 1480|Homo sapiens cystic fibrosis transme... 100 4e-20
DQ388129-1|ABD72185.1| 1480|Homo sapiens cystic fibrosis transme... 100 4e-20
DQ388128-1|ABD72183.1| 1480|Homo sapiens cystic fibrosis transme... 100 4e-20
DQ356264-1|ABC87067.1| 1480|Homo sapiens cystic fibrosis transme... 100 4e-20
DQ356263-1|ABC87065.1| 1480|Homo sapiens cystic fibrosis transme... 100 4e-20
DQ356262-1|ABC87063.1| 1480|Homo sapiens cystic fibrosis transme... 100 4e-20
DQ356261-1|ABC87061.1| 1462|Homo sapiens cystic fibrosis transme... 100 4e-20
DQ356260-1|ABC87059.1| 1480|Homo sapiens cystic fibrosis transme... 100 4e-20
DQ356259-1|ABC87057.1| 1480|Homo sapiens cystic fibrosis transme... 100 4e-20
DQ356258-1|ABC87055.1| 1462|Homo sapiens cystic fibrosis transme... 100 4e-20
DQ356257-1|ABC87053.1| 1480|Homo sapiens cystic fibrosis transme... 100 4e-20
DQ354391-1|ABC79056.1| 1480|Homo sapiens cystic fibrosis transme... 100 4e-20
DQ354390-1|ABC79054.1| 1480|Homo sapiens cystic fibrosis transme... 100 4e-20
DQ354389-1|ABC79052.1| 1480|Homo sapiens cystic fibrosis transme... 100 4e-20
DQ354388-1|ABC79050.1| 1480|Homo sapiens cystic fibrosis transme... 100 4e-20
AC000061-1|AAB46340.2| 484|Homo sapiens unknown protein. 100 4e-20
AF085691-1|AAD02846.1| 1238|Homo sapiens multidrug resistance-as... 97 4e-19
AY848829-1|AAW33656.1| 258|Homo sapiens cystic fibrosis transme... 93 4e-18
S83249-1|AAP31917.1| 125|Homo sapiens transporter protein/putat... 93 8e-18
AY848830-1|AAW33657.1| 241|Homo sapiens cystic fibrosis transme... 90 5e-17
AB012959-1|BAA88711.1| 63|Homo sapiens sister p-glycoprotein p... 88 2e-16
AL359813-4|CAI23219.1| 172|Homo sapiens ATP-binding cassette, s... 87 3e-16
AK094171-1|BAC04300.1| 120|Homo sapiens protein ( Homo sapiens ... 87 5e-16
AL359813-5|CAI23220.1| 157|Homo sapiens ATP-binding cassette, s... 85 2e-15
AC002457-1|AAM49149.1| 234|Homo sapiens unknown protein. 83 5e-15
U83660-1|AAB71757.1| 162|Homo sapiens multidrug resistance-asso... 83 6e-15
DQ388144-1|ABD72215.1| 1480|Homo sapiens cystic fibrosis transme... 82 1e-14
AC000111-1|AAB46352.1| 996|Homo sapiens unknown protein. 82 1e-14
BC130280-1|AAI30281.1| 1621|Homo sapiens ABCA8 protein protein. 79 8e-14
AY028899-1|AAK30024.1| 1624|Homo sapiens ATP-binding cassette A9... 76 7e-13
AK074491-1|BAC11021.1| 483|Homo sapiens protein ( Homo sapiens ... 76 7e-13
AK057068-1|BAB71359.1| 856|Homo sapiens protein ( Homo sapiens ... 76 7e-13
AF423346-1|AAN32752.1| 1624|Homo sapiens ATP-binding cassette su... 76 7e-13
AF423307-1|AAN32751.1| 1624|Homo sapiens ATP-binding cassette su... 76 7e-13
X97187-1|CAA65825.1| 1704|Homo sapiens ABC-C transporter protein. 76 9e-13
U78735-1|AAC50967.1| 1704|Homo sapiens ABC3 protein. 76 9e-13
DQ073080-1|AAY57325.1| 1704|Homo sapiens ATP-binding cassette, s... 76 9e-13
AB210044-1|BAE06126.1| 1708|Homo sapiens ABCA3 variant protein p... 76 9e-13
AB070929-1|BAB86781.1| 1704|Homo sapiens lamellar body membrane ... 76 9e-13
BX640746-1|CAE45856.1| 431|Homo sapiens hypothetical protein pr... 75 2e-12
AY028897-1|AAK30022.1| 1642|Homo sapiens ATP-binding cassette A5... 75 2e-12
AJ275973-1|CAB93535.3| 1642|Homo sapiens ATP-binding cassette pr... 75 2e-12
AJ512612-1|CAD54757.1| 925|Homo sapiens ABCA5 transporter protein. 74 3e-12
X91249-1|CAA62631.1| 674|Homo sapiens white protein. 73 7e-12
U34919-1|AAC51098.1| 638|Homo sapiens white homolog protein. 73 7e-12
BC029158-1|AAH29158.2| 666|Homo sapiens ATP-binding cassette, s... 73 7e-12
AP001746-1|BAA95530.1| 674|Homo sapiens white protein homolog (... 73 7e-12
AJ289137-1|CAC00730.1| 674|Homo sapiens ATP-binding cassette tr... 73 7e-12
AF323664-1|AAK28842.1| 677|Homo sapiens ATP-binding cassette tr... 73 7e-12
AF323663-1|AAK28841.1| 662|Homo sapiens ATP-binding cassette tr... 73 7e-12
AF323662-1|AAK28840.1| 663|Homo sapiens ATP-binding cassette tr... 73 7e-12
AF323661-1|AAK28839.1| 644|Homo sapiens ATP-binding cassette tr... 73 7e-12
AF323660-1|AAK28838.1| 668|Homo sapiens ATP-binding cassette tr... 73 7e-12
AF323658-5|AAK28834.1| 644|Homo sapiens ATP-binding cassette tr... 73 7e-12
AF323658-4|AAK28836.1| 677|Homo sapiens ATP-binding cassette tr... 73 7e-12
AF323658-3|AAK28837.1| 662|Homo sapiens ATP-binding cassette tr... 73 7e-12
AF323658-2|AAK28835.1| 663|Homo sapiens ATP-binding cassette tr... 73 7e-12
AF323658-1|AAK28833.1| 668|Homo sapiens ATP-binding cassette tr... 73 7e-12
AB038161-1|BAB13728.2| 674|Homo sapiens ABC transporter protein. 73 7e-12
AF000148-1|AAC23915.1| 2273|Homo sapiens ATP-binding cassette tr... 72 1e-11
Y15635-1|CAA75729.1| 2273|Homo sapiens ABCR protein. 72 2e-11
U88667-1|AAC51144.1| 2273|Homo sapiens ATP-binding cassette tran... 72 2e-11
AY247105-1|AAO72160.1| 1543|Homo sapiens ATP-binding cassette su... 72 2e-11
AY247065-1|AAO72161.1| 1543|Homo sapiens ATP-binding cassette su... 72 2e-11
AY219711-1|AAP21093.1| 2595|Homo sapiens ABCA12 transporter subf... 72 2e-11
AY033486-1|AAK54355.1| 2277|Homo sapiens ATP-binding cassette tr... 72 2e-11
AY028900-1|AAK30025.1| 1543|Homo sapiens ATP-binding cassette A1... 72 2e-11
AF418105-1|AAN40735.1| 2347|Homo sapiens ATP-binding cassette tr... 72 2e-11
AF001945-1|AAC05632.1| 2273|Homo sapiens rim ABC transporter pro... 72 2e-11
AC072062-1|AAY24276.1| 2413|Homo sapiens unknown protein. 72 2e-11
AB210040-1|BAE06122.1| 2303|Homo sapiens ABCA4 variant protein p... 72 2e-11
BC125232-1|AAI25233.1| 1500|Homo sapiens ABCA6 protein protein. 71 2e-11
BC125231-1|AAI25232.1| 1500|Homo sapiens ABCA6 protein protein. 71 2e-11
AY028898-1|AAK30023.1| 1617|Homo sapiens ATP-binding cassette A6... 71 2e-11
AF373328-1|AAM77558.1| 1617|Homo sapiens ABC transporter ABCA6 p... 71 2e-11
AF373290-1|AAM77557.1| 1617|Homo sapiens ABC transporter ABCA6 p... 71 2e-11
AL359846-6|CAH73579.1| 2261|Homo sapiens ATP-binding cassette, s... 70 5e-11
AL353685-3|CAH72444.1| 2261|Homo sapiens ATP-binding cassette, s... 70 5e-11
AK130814-1|BAC85435.1| 546|Homo sapiens protein ( Homo sapiens ... 70 5e-11
AJ012376-1|CAA10005.1| 2201|Homo sapiens ATP-binding cassette tr... 70 5e-11
AF285167-1|AAF98175.1| 2261|Homo sapiens ATP-binding cassette tr... 70 5e-11
AF275948-1|AAF86276.1| 2261|Homo sapiens ABCA1 protein. 70 5e-11
AF165281-1|AAD49849.1| 2201|Homo sapiens ATP cassette binding tr... 70 5e-11
AB055982-1|BAB63210.1| 2261|Homo sapiens ABCA1 protein. 70 5e-11
AF328787-1|AAK00959.1| 2146|Homo sapiens ABC transporter member ... 69 8e-11
AF311102-1|AAN04657.1| 2146|Homo sapiens ABC transporter ABCA7 p... 69 8e-11
AF250238-1|AAF85794.1| 2146|Homo sapiens macrophage ABC transpor... 69 8e-11
AB055390-1|BAB62294.1| 2008|Homo sapiens ABCA-SSN protein. 69 8e-11
AF287262-1|AAK43526.1| 2261|Homo sapiens ATP-binding cassette 1 ... 69 1e-10
AK128129-1|BAC87287.1| 467|Homo sapiens . protein. 68 2e-10
AL807752-22|CAI12768.1| 2435|Homo sapiens ATP-binding cassette, ... 68 2e-10
AF327705-1|AAK14335.1| 2436|Homo sapiens ABC transporter ABCA2 p... 68 2e-10
AF327657-1|AAK14334.1| 2436|Homo sapiens ABC transporter ABCA2 p... 68 2e-10
AF178941-1|AAG09372.1| 2436|Homo sapiens ATP-binding cassette su... 68 2e-10
AB177854-1|BAD66832.1| 1440|Homo sapiens KIAA1062 splice variant... 68 2e-10
AB028985-1|BAA83014.2| 1771|Homo sapiens KIAA1062 protein protein. 68 2e-10
X58528-1|CAA41416.1| 659|Homo sapiens 70kDa peroxisomal membran... 66 8e-10
BC041091-1|AAH41091.1| 646|Homo sapiens ATP-binding cassette, s... 66 8e-10
AJ308237-1|CAC87131.1| 646|Homo sapiens ABC transporter protein. 66 8e-10
AJ300465-1|CAC17140.1| 627|Homo sapiens putative white family A... 66 8e-10
AY204751-1|AAP13576.1| 5058|Homo sapiens ABC A13 protein. 66 1e-09
AY048757-1|AAL06598.1| 785|Homo sapiens ATP-binding cassette tr... 66 1e-09
AK131360-1|BAD18512.1| 1186|Homo sapiens mRNA. protein. 66 1e-09
AF501281-1|AAO59914.1| 2127|Homo sapiens ATP binding cassette tr... 66 1e-09
Z31348-1|CAA83230.1| 745|Homo sapiens adrenoleukodystropy protein. 65 1e-09
Z21876-1|CAA79922.1| 745|Homo sapiens ALD protein (ALDP) protein. 65 1e-09
BC025358-1|AAH25358.1| 745|Homo sapiens ATP-binding cassette, s... 65 1e-09
BC015541-1|AAH15541.1| 745|Homo sapiens ATP-binding cassette, s... 65 1e-09
M81182-1|AAA60128.1| 659|Homo sapiens 70kDa peroxisomal membran... 64 2e-09
BC068509-1|AAH68509.1| 549|Homo sapiens ABCD3 protein protein. 64 2e-09
AL138758-1|CAC15960.2| 659|Homo sapiens ATP-binding cassette, s... 64 2e-09
DQ388136-1|ABD72199.1| 1321|Homo sapiens cystic fibrosis transme... 64 4e-09
AF492485-1|AAM11658.1| 45|Homo sapiens TAP1 protein. 63 5e-09
AY849794-1|AAW33782.1| 159|Homo sapiens cystic fibrosis transme... 61 3e-08
AY848832-1|AAW33659.1| 418|Homo sapiens cystic fibrosis transme... 61 3e-08
AY848831-1|AAW33658.1| 405|Homo sapiens cystic fibrosis transme... 61 3e-08
AY848828-1|AAW33655.1| 159|Homo sapiens cystic fibrosis transme... 61 3e-08
AF320293-1|AAG40003.1| 651|Homo sapiens ABCG5 protein. 61 3e-08
AF312715-1|AAG53099.1| 651|Homo sapiens sterolin protein. 61 3e-08
AC108476-1|AAY24010.1| 549|Homo sapiens unknown protein. 61 3e-08
BC104903-1|AAI04904.1| 740|Homo sapiens ATP-binding cassette, s... 60 4e-08
BC104901-1|AAI04902.1| 740|Homo sapiens ATP-binding cassette, s... 60 4e-08
AJ000327-1|CAA03994.1| 740|Homo sapiens adrenoleukodystrophy re... 60 4e-08
AF119831-1|AAD30439.1| 740|Homo sapiens adrenoleukodystrophy-re... 60 4e-08
U16763-1|AAA89080.1| 44|Homo sapiens TAP1 protein. 60 7e-08
U07197-1|AAB60321.1| 45|Homo sapiens TAP1 protein. 59 1e-07
BC113657-1|AAI13658.1| 673|Homo sapiens ATP-binding cassette, s... 59 1e-07
AF351824-1|AAK84663.1| 672|Homo sapiens sterolin-2 protein. 59 1e-07
AF324494-1|AAK84078.1| 673|Homo sapiens sterolin-2 protein. 59 1e-07
AF320294-1|AAG40004.1| 673|Homo sapiens ABCG8 protein. 59 1e-07
AC108476-2|AAY24011.1| 673|Homo sapiens unknown protein. 59 1e-07
Y14318-1|CAA74699.1| 606|Homo sapiens peroxisomal ABC-transport... 58 2e-07
CR457104-1|CAG33385.1| 606|Homo sapiens ABCD4 protein. 58 2e-07
BT007412-1|AAP36080.1| 606|Homo sapiens ATP-binding cassette, s... 58 2e-07
BC012815-1|AAH12815.1| 606|Homo sapiens ATP-binding cassette, s... 58 2e-07
AF009746-1|AAB83967.1| 606|Homo sapiens peroxisomal membrane pr... 58 2e-07
AK128570-1|BAC87504.1| 851|Homo sapiens protein ( Homo sapiens ... 56 8e-07
BC008755-1|AAH08755.1| 867|Homo sapiens ABCA2 protein protein. 55 2e-06
AK056533-1|BAB71208.1| 865|Homo sapiens protein ( Homo sapiens ... 55 2e-06
X83467-1|CAA58470.1| 660|Homo sapiens 70kD peroxisomal integral... 54 2e-06
M37725-1|AAA88048.1| 57|Homo sapiens PGY1 protein. 54 2e-06
AK058170-1|BAB71700.1| 364|Homo sapiens protein ( Homo sapiens ... 54 2e-06
AB067475-1|BAB67781.1| 737|Homo sapiens KIAA1888 protein protein. 54 2e-06
AB020629-1|BAA74845.2| 1591|Homo sapiens KIAA0822 protein protein. 54 2e-06
AY785909-1|AAX11382.1| 134|Homo sapiens ATP-binding cassette su... 54 3e-06
BC051320-1|AAH51320.1| 419|Homo sapiens ABCA10 protein protein. 54 4e-06
AL807752-20|CAI12766.1| 226|Homo sapiens ATP-binding cassette, ... 53 7e-06
AL162060-1|CAB82398.1| 373|Homo sapiens hypothetical protein pr... 53 7e-06
DQ996467-1|ABI97388.1| 655|Homo sapiens ATP-binding cassette, s... 52 1e-05
BC092408-1|AAH92408.1| 611|Homo sapiens ABCG2 protein protein. 52 1e-05
BC021281-1|AAH21281.1| 655|Homo sapiens ATP-binding cassette, s... 52 1e-05
AY333756-1|AAQ92942.1| 655|Homo sapiens ATP-binding cassette su... 52 1e-05
AY333755-1|AAQ92941.1| 655|Homo sapiens mutant ATP-binding cass... 52 1e-05
AY289766-1|AAP44087.1| 655|Homo sapiens ABC transporter protein. 52 1e-05
AY017168-1|AAG52982.1| 655|Homo sapiens ABC transporter ABCG2 p... 52 1e-05
AF463519-1|AAO14617.1| 655|Homo sapiens ATP-binding cassette pr... 52 1e-05
AF103796-1|AAD09188.1| 655|Homo sapiens placenta-specific ATP-b... 52 1e-05
AF098951-1|AAC97367.1| 655|Homo sapiens breast cancer resistanc... 52 1e-05
AC097484-1|AAY40902.1| 607|Homo sapiens unknown protein. 52 1e-05
AB056867-1|BAB39212.1| 655|Homo sapiens Breast Cancer Resistanc... 52 1e-05
AB051855-1|BAB46933.1| 655|Homo sapiens ATP-binding cassette su... 52 1e-05
AL137481-1|CAB70762.1| 269|Homo sapiens hypothetical protein pr... 52 1e-05
AK128516-1|BAC87475.1| 788|Homo sapiens protein ( Homo sapiens ... 52 2e-05
AK097296-1|BAC04994.1| 815|Homo sapiens protein ( Homo sapiens ... 51 2e-05
AF165306-1|AAD49852.1| 849|Homo sapiens ATP cassette binding tr... 51 2e-05
S70266-1|AAD14055.1| 33|Homo sapiens TAP1 protein. 50 4e-05
S70274-1|AAD14056.1| 33|Homo sapiens TAP1 protein. 50 5e-05
BX248518-8|CAM26018.1| 238|Homo sapiens ATP-binding cassette su... 48 2e-04
BX248518-7|CAM26017.1| 845|Homo sapiens ATP-binding cassette su... 48 2e-04
BX248518-6|CAM26016.1| 807|Homo sapiens ATP-binding cassette su... 48 2e-04
BX119957-4|CAM25908.1| 238|Homo sapiens ATP-binding cassette su... 48 2e-04
BX119957-3|CAM25907.1| 845|Homo sapiens ATP-binding cassette su... 48 2e-04
BX119957-2|CAM25906.1| 807|Homo sapiens ATP-binding cassette su... 48 2e-04
BX000357-8|CAI18563.1| 845|Homo sapiens ATP-binding cassette, s... 48 2e-04
BX000357-7|CAM25770.1| 238|Homo sapiens ATP-binding cassette, s... 48 2e-04
BX000357-6|CAI18562.1| 807|Homo sapiens ATP-binding cassette, s... 48 2e-04
BC112923-1|AAI12924.1| 845|Homo sapiens ATP-binding cassette, s... 48 2e-04
BC034488-1|AAH34488.1| 845|Homo sapiens ATP-binding cassette, s... 48 2e-04
BA000025-75|BAB63325.1| 807|Homo sapiens TNFalpha-inducible ATP... 48 2e-04
AL662825-8|CAI17836.1| 807|Homo sapiens ATP-binding cassette, s... 48 2e-04
AL662825-7|CAI17837.1| 845|Homo sapiens ATP-binding cassette, s... 48 2e-04
AL662825-6|CAM25037.1| 238|Homo sapiens ATP-binding cassette, s... 48 2e-04
AL662800-8|CAI18158.1| 845|Homo sapiens ATP-binding cassette, s... 48 2e-04
AL662800-7|CAI18159.1| 807|Homo sapiens ATP-binding cassette, s... 48 2e-04
AL662800-6|CAI18157.2| 238|Homo sapiens ATP-binding cassette, s... 48 2e-04
AF027302-1|AAC70891.1| 807|Homo sapiens TNF-alpha stimulated AB... 48 2e-04
AB209564-1|BAD92801.1| 593|Homo sapiens ATP-binding cassette, s... 48 2e-04
AB202093-1|BAE78612.1| 807|Homo sapiens ATP-binding cassette, s... 48 2e-04
AB103602-1|BAF31263.1| 807|Homo sapiens ABC50 protein protein. 48 2e-04
AB088096-1|BAC54928.1| 807|Homo sapiens ATP-binding cassette, s... 48 2e-04
S70256-1|AAD14054.1| 33|Homo sapiens TAP1 protein. 48 3e-04
D78570-1|BAA11414.1| 69|Homo sapiens TAP2 protein. 48 3e-04
BC020618-1|AAH20618.1| 179|Homo sapiens ABCB4 protein protein. 48 3e-04
DQ148409-1|AAZ38723.1| 599|Homo sapiens ATP-binding cassette, s... 47 5e-04
BT009779-1|AAP88781.1| 599|Homo sapiens ATP-binding cassette, s... 47 5e-04
BC016283-1|AAH16283.1| 599|Homo sapiens ATP-binding cassette, s... 47 5e-04
AB062293-1|BAB93476.1| 599|Homo sapiens ATP-binding cassette su... 47 5e-04
BC051884-1|AAH51884.2| 709|Homo sapiens ATP-binding cassette, s... 45 0.001
BC051754-1|AAH51754.1| 709|Homo sapiens ATP-binding cassette, s... 45 0.001
BC009253-1|AAH09253.1| 709|Homo sapiens ATP-binding cassette, s... 45 0.001
AY288307-1|AAP31310.1| 541|Homo sapiens ATP-binding cassette su... 45 0.001
AK091270-1|BAC03623.1| 293|Homo sapiens protein ( Homo sapiens ... 45 0.001
AK002060-1|BAA92063.1| 709|Homo sapiens protein ( Homo sapiens ... 45 0.001
AJ278917-1|CAC07210.1| 109|Homo sapiens putative ATP-binding ca... 45 0.001
U18236-1|AAA84437.2| 131|Homo sapiens ATP-binding cassette prot... 45 0.002
BC016988-1|AAH16988.1| 345|Homo sapiens Unknown (protein for IM... 45 0.002
AK092415-1|BAC03881.1| 703|Homo sapiens protein ( Homo sapiens ... 44 0.003
AK024758-1|BAB14989.1| 390|Homo sapiens protein ( Homo sapiens ... 44 0.003
AF356348-1|AAL35305.1| 103|Homo sapiens breast cancer resistanc... 44 0.003
AJ575045-1|CAE00759.1| 58|Homo sapiens cystic fibrosis transme... 44 0.005
AJ575044-1|CAE00758.1| 58|Homo sapiens cystic fibrosis transme... 44 0.005
AJ575043-1|CAE00757.1| 58|Homo sapiens cystic fibrosis transme... 44 0.005
AJ575042-1|CAE00756.1| 58|Homo sapiens cystic fibrosis transme... 44 0.005
AJ575041-1|CAE00755.2| 58|Homo sapiens cystic fibrosis transme... 44 0.005
X76388-1|CAA53972.1| 599|Homo sapiens RNase L inhibitor protein. 41 0.032
X74987-1|CAA52920.1| 402|Homo sapiens endoribonuclease protein. 41 0.032
BT007451-1|AAP36119.1| 623|Homo sapiens ATP-binding cassette, s... 40 0.056
BC001661-1|AAH01661.1| 623|Homo sapiens ATP-binding cassette, s... 40 0.056
AJ005016-1|CAA06290.1| 550|Homo sapiens ABC transporter protein. 40 0.056
AF261092-1|AAG13903.1| 623|Homo sapiens iron inhibited ABC tran... 40 0.056
AF261091-1|AAG13902.1| 623|Homo sapiens iron inhibited ABC tran... 40 0.056
AC021097-3|AAS00379.1| 623|Homo sapiens unknown protein. 40 0.056
AC021097-2|AAS00378.1| 634|Homo sapiens unknown protein. 40 0.056
AL353692-3|CAI16236.1| 5596|Homo sapiens MDN1, midasin homolog (... 35 1.6
AL158813-2|CAI13203.1| 5596|Homo sapiens MDN1, midasin homolog (... 35 1.6
AL096678-1|CAI42279.1| 5596|Homo sapiens MDN1, midasin homolog (... 35 1.6
AF503925-1|AAM77722.1| 5596|Homo sapiens midasin protein. 35 1.6
AJ575033-1|CAE00747.1| 52|Homo sapiens cystic fibrosis transme... 34 2.8
AJ575032-1|CAE00746.1| 52|Homo sapiens cystic fibrosis transme... 34 2.8
AJ575031-1|CAE00745.1| 52|Homo sapiens cystic fibrosis transme... 34 2.8
AJ575030-1|CAE00744.1| 52|Homo sapiens cystic fibrosis transme... 34 2.8
AJ575029-1|CAE00743.1| 52|Homo sapiens cystic fibrosis transme... 34 2.8
AJ575028-1|CAE00742.1| 52|Homo sapiens cystic fibrosis transme... 34 2.8
BC036378-1|AAH36378.1| 633|Homo sapiens ABCC12 protein protein. 34 3.7
L09234-1|AAA35578.1| 615|Homo sapiens ATPase protein. 33 6.5
AY421738-1|AAR07958.1| 240|Homo sapiens mutant adrenoleukodystr... 33 6.5
AY007425-1|AAG12163.1| 109|Homo sapiens TAP2 protein protein. 33 6.5
AL080207-1|CAB45776.1| 196|Homo sapiens hypothetical protein pr... 33 6.5
AK002040-1|BAA92050.1| 456|Homo sapiens protein ( Homo sapiens ... 33 6.5
AY421737-1|AAR07957.1| 240|Homo sapiens mutant adrenoleukodystr... 33 8.6
>M29447-1|AAA59576.1| 1280|Homo sapiens P glycoprotein protein.
Length = 1280
Score = 775 bits (1917), Expect = 0.0
Identities = 437/1176 (37%), Positives = 671/1176 (57%), Gaps = 48/1176 (4%)
Query: 18 VSFFQIFRYGNCLELLATALGVVFGMISGAGVCCNLLQIGELSTAFVERTKYHDRLSSYL 77
VS F +FRY N L+ L +G + +I GAG+ +L GE++ F D +S+
Sbjct: 34 VSVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNIT 93
Query: 78 PLTATFGGGKRLVNATHEQNMEALIDDAKAMAIGMFISIGVSLVFCVLSFSLISWSALRQ 137
+ G +N E++M + G+ ++ + + F L+ A RQ
Sbjct: 94 NRSDINDTGF-FMNL--EEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLA-------AGRQ 143
Query: 138 ITRIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVIC 197
I +IR F +++RQ++ W+D L +++++++ I EG+G+K+ + + T
Sbjct: 144 IHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTG 203
Query: 198 LCTAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRT 257
F GW+LTL A+ P +++ + + + +E+ +Y+ AG AEE+L ++RT
Sbjct: 204 FIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRT 263
Query: 258 IVAFGGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVN 317
++AFGG+ KE+ERY + LE A+ G K+ + + G ++L Y+ A+ F YGT LV++
Sbjct: 264 VIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLS 323
Query: 318 DFDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKI 377
+Y +G V ++ FSV + S+ P +E F IF +I+ +P I
Sbjct: 324 G--------EYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSI 375
Query: 378 DSLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKST 437
DS + G P + G++ +V F YPSR EVK+LKG ++ V+ G+ VALVG+SGCGKST
Sbjct: 376 DSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKST 435
Query: 438 VLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEA 497
+QL+QRLYDP G V +LR +GVV QEPVLF TI +NI G
Sbjct: 436 TVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENV 495
Query: 498 TREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLD 557
T +EI++ + A A+DFI LP+ +DT++GERGA LSGGQKQRIAIAR+L+R P +LLLD
Sbjct: 496 TMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLD 555
Query: 558 EATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDL 617
EATSALD SE VQ ALD+A GRTTI ++HRLST+ NAD I D GVIVE+G H++L
Sbjct: 556 EATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDEL 615
Query: 618 MKAKGFYHKLVTTGNENKEPADIEPLIEEADGDGDNIEPTVPSRLDVRRRSSKKVLRHHS 677
MK KG Y KLVT E ++E +E+ + D +E + S ++R S
Sbjct: 616 MKEKGIYFKLVTMQTAGNE-VELENAADESKSEIDALEMS-------SNDSRSSLIRKRS 667
Query: 678 IKKDHPDWLTPRGSISSMVSIGLQNFVFNXXXXXXXXXXXXXTVKTVSDWQLLKLNAPEW 737
++ + RGS + + + + ++ VS W+++KLN EW
Sbjct: 668 TRR------SVRGSQAQDRKLSTKEAL-------------DESIPPVSFWRIMKLNLTEW 708
Query: 738 PLITVGSIAAFLQGACFPVFALLFGFSSGIFI-LDNRDDIIYLADLYSVLFVVIAAVAGI 796
P VG A + G P FA++F G+F +D+ + ++L+S+LF+ + ++ I
Sbjct: 709 PYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFI 768
Query: 797 SMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGA 856
+ LQ TF AG +T RLR+ F S+L+Q++ +FD NT GA+ RL+ D A+V+GA
Sbjct: 769 TFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGA 828
Query: 857 TGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERN 916
G R+ +I Q I+++ G +++ Y W+LTL+ +P++ + +E + + ++
Sbjct: 829 IGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKK 888
Query: 917 AMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVAYKTRWRGLVYGLGVYI 976
+E A IATEA+ + +TV SL E F + +L+ K G+ + +
Sbjct: 889 ELEGAGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAM 948
Query: 977 PFMAYCSATVYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYAPSLNTAKACGARI 1036
+ +Y +GA LVA+ M ++ VLLV A+++GA +GQ +AP AK A I
Sbjct: 949 MYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHI 1008
Query: 1037 LSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTIA 1096
+ II++ P I ++ + GN + +V F YPTRP VL+G+ L+++ G+T+A
Sbjct: 1009 IMIIEKTPLI-DSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLA 1067
Query: 1097 LVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRS 1156
LVGSSGCGKST++QL +RFYDP +G + LD ++I+ L + LR LG+V QEP+L D S
Sbjct: 1068 LVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIK-RLNVQWLRAHLGIVSQEPILFDCS 1126
Query: 1157 LAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP 1192
+AENIAYGDN+R V+ EIV AAK ANIH+FI SLP
Sbjct: 1127 IAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLP 1162
Score = 348 bits (855), Expect = 9e-95
Identities = 196/495 (39%), Positives = 283/495 (57%), Gaps = 14/495 (2%)
Query: 140 RIRTLFLRSVLRQDMSWYDTDSEFN--LASKMSENLMSIKEGMGEKLAVVSNLVGTSVIC 197
R+R + RS+LRQD+SW+D L ++++ + +K +G +LAV++ +
Sbjct: 787 RLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTG 846
Query: 198 LCTAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRT 257
+ +F GWQLTL A++P I + + ++++ + AGK A E +++ RT
Sbjct: 847 IIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRT 906
Query: 258 IVAFGGENKEVERYRRLLE-PAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVV 316
+V+ E K Y + L+ P RK +F G+ F + Y A F +G LV
Sbjct: 907 VVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIF-GITFSFTQAMMYFSYAGCFRFGAYLVA 965
Query: 317 NDFDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPK 376
+ + + V V+S + MA ++ P + I +IE+ P
Sbjct: 966 HKLMSFED-----VLLVFSAVVFGAMAVGQVSSFAPD---YAKAKISAAHIIMIIEKTPL 1017
Query: 377 IDSLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKS 436
IDS +GL P + G++ +V F YP+RP++ VL+G S+ VK G+ +ALVGSSGCGKS
Sbjct: 1018 IDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKS 1077
Query: 437 TVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIG--S 494
TV+QLL+R YDP AG V WLR+ LG+V QEP+LF +I +NIA G S
Sbjct: 1078 TVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNS 1137
Query: 495 PEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVL 554
++EEI R A+ A H FI LPN Y T +G++G LSGGQKQRIAIAR+L+R+P +L
Sbjct: 1138 RVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHIL 1197
Query: 555 LLDEATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTH 614
LLDEATSALD SE+ VQ ALD+A GRT I ++HRLSTI NAD I+ G + E GTH
Sbjct: 1198 LLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTH 1257
Query: 615 EDLMKAKGFYHKLVT 629
+ L+ KG Y +V+
Sbjct: 1258 QQLLAQKGIYFSMVS 1272
Score = 77.0 bits (181), Expect = 4e-13
Identities = 34/59 (57%), Positives = 45/59 (76%)
Query: 1193 KAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRM 1251
K V EAL+KA +GRTCI IAHRLST+++ADLI V G++ E GTH +L++ KG Y+ M
Sbjct: 1212 KVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSM 1270
Score = 68.5 bits (160), Expect = 1e-10
Identities = 33/57 (57%), Positives = 42/57 (73%)
Query: 1195 VTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRM 1251
V AL+KA KGRT I IAHRLSTV++AD+I D G IVE+G H EL+ KG Y+++
Sbjct: 569 VQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKL 625
>AY910577-1|AAW82430.1| 1280|Homo sapiens ATP-binding cassette,
sub-family B (MDR/TAP), member 1 protein.
Length = 1280
Score = 775 bits (1917), Expect = 0.0
Identities = 437/1176 (37%), Positives = 671/1176 (57%), Gaps = 48/1176 (4%)
Query: 18 VSFFQIFRYGNCLELLATALGVVFGMISGAGVCCNLLQIGELSTAFVERTKYHDRLSSYL 77
VS F +FRY N L+ L +G + +I GAG+ +L GE++ F D +S+
Sbjct: 34 VSVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNIT 93
Query: 78 PLTATFGGGKRLVNATHEQNMEALIDDAKAMAIGMFISIGVSLVFCVLSFSLISWSALRQ 137
+ G +N E++M + G+ ++ + + F L+ A RQ
Sbjct: 94 NRSDINDTGF-FMNL--EEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLA-------AGRQ 143
Query: 138 ITRIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVIC 197
I +IR F +++RQ++ W+D L +++++++ I EG+G+K+ + + T
Sbjct: 144 IHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTG 203
Query: 198 LCTAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRT 257
F GW+LTL A+ P +++ + + + +E+ +Y+ AG AEE+L ++RT
Sbjct: 204 FIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRT 263
Query: 258 IVAFGGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVN 317
++AFGG+ KE+ERY + LE A+ G K+ + + G ++L Y+ A+ F YGT LV++
Sbjct: 264 VIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLS 323
Query: 318 DFDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKI 377
+Y +G V ++ FSV + S+ P +E F IF +I+ +P I
Sbjct: 324 G--------EYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSI 375
Query: 378 DSLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKST 437
DS + G P + G++ +V F YPSR EVK+LKG ++ V+ G+ VALVG+SGCGKST
Sbjct: 376 DSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKST 435
Query: 438 VLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEA 497
+QL+QRLYDP G V +LR +GVV QEPVLF TI +NI G
Sbjct: 436 TVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENV 495
Query: 498 TREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLD 557
T +EI++ + A A+DFI LP+ +DT++GERGA LSGGQKQRIAIAR+L+R P +LLLD
Sbjct: 496 TMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLD 555
Query: 558 EATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDL 617
EATSALD SE VQ ALD+A GRTTI ++HRLST+ NAD I D GVIVE+G H++L
Sbjct: 556 EATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDEL 615
Query: 618 MKAKGFYHKLVTTGNENKEPADIEPLIEEADGDGDNIEPTVPSRLDVRRRSSKKVLRHHS 677
MK KG Y KLVT E ++E +E+ + D +E + S ++R S
Sbjct: 616 MKEKGIYFKLVTMQTAGNE-VELENAADESKSEIDALEMS-------SNDSRSSLIRKRS 667
Query: 678 IKKDHPDWLTPRGSISSMVSIGLQNFVFNXXXXXXXXXXXXXTVKTVSDWQLLKLNAPEW 737
++ + RGS + + + + ++ VS W+++KLN EW
Sbjct: 668 TRR------SVRGSQAQDRKLSTKEAL-------------DESIPPVSFWRIMKLNLTEW 708
Query: 738 PLITVGSIAAFLQGACFPVFALLFGFSSGIFI-LDNRDDIIYLADLYSVLFVVIAAVAGI 796
P VG A + G P FA++F G+F +D+ + ++L+S+LF+ + ++ I
Sbjct: 709 PYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFI 768
Query: 797 SMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGA 856
+ LQ TF AG +T RLR+ F S+L+Q++ +FD NT GA+ RL+ D A+V+GA
Sbjct: 769 TFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGA 828
Query: 857 TGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERN 916
G R+ +I Q I+++ G +++ Y W+LTL+ +P++ + +E + + ++
Sbjct: 829 IGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKK 888
Query: 917 AMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVAYKTRWRGLVYGLGVYI 976
+E A IATEA+ + +TV SL E F + +L+ K G+ + +
Sbjct: 889 ELEGAGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAM 948
Query: 977 PFMAYCSATVYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYAPSLNTAKACGARI 1036
+ +Y +GA LVA+ M ++ VLLV A+++GA +GQ +AP AK A I
Sbjct: 949 MYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHI 1008
Query: 1037 LSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTIA 1096
+ II++ P I ++ + GN + +V F YPTRP VL+G+ L+++ G+T+A
Sbjct: 1009 IMIIEKTPLI-DSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLA 1067
Query: 1097 LVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRS 1156
LVGSSGCGKST++QL +RFYDP +G + LD ++I+ L + LR LG+V QEP+L D S
Sbjct: 1068 LVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIK-RLNVQWLRAHLGIVSQEPILFDCS 1126
Query: 1157 LAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP 1192
+AENIAYGDN+R V+ EIV AAK ANIH+FI SLP
Sbjct: 1127 IAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLP 1162
Score = 348 bits (855), Expect = 9e-95
Identities = 196/495 (39%), Positives = 283/495 (57%), Gaps = 14/495 (2%)
Query: 140 RIRTLFLRSVLRQDMSWYDTDSEFN--LASKMSENLMSIKEGMGEKLAVVSNLVGTSVIC 197
R+R + RS+LRQD+SW+D L ++++ + +K +G +LAV++ +
Sbjct: 787 RLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTG 846
Query: 198 LCTAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRT 257
+ +F GWQLTL A++P I + + ++++ + AGK A E +++ RT
Sbjct: 847 IIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRT 906
Query: 258 IVAFGGENKEVERYRRLLE-PAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVV 316
+V+ E K Y + L+ P RK +F G+ F + Y A F +G LV
Sbjct: 907 VVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIF-GITFSFTQAMMYFSYAGCFRFGAYLVA 965
Query: 317 NDFDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPK 376
+ + + V V+S + MA ++ P + I +IE+ P
Sbjct: 966 HKLMSFED-----VLLVFSAVVFGAMAVGQVSSFAPD---YAKAKISAAHIIMIIEKTPL 1017
Query: 377 IDSLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKS 436
IDS +GL P + G++ +V F YP+RP++ VL+G S+ VK G+ +ALVGSSGCGKS
Sbjct: 1018 IDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKS 1077
Query: 437 TVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIG--S 494
TV+QLL+R YDP AG V WLR+ LG+V QEP+LF +I +NIA G S
Sbjct: 1078 TVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNS 1137
Query: 495 PEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVL 554
++EEI R A+ A H FI LPN Y T +G++G LSGGQKQRIAIAR+L+R+P +L
Sbjct: 1138 RVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHIL 1197
Query: 555 LLDEATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTH 614
LLDEATSALD SE+ VQ ALD+A GRT I ++HRLSTI NAD I+ G + E GTH
Sbjct: 1198 LLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTH 1257
Query: 615 EDLMKAKGFYHKLVT 629
+ L+ KG Y +V+
Sbjct: 1258 QQLLAQKGIYFSMVS 1272
Score = 77.0 bits (181), Expect = 4e-13
Identities = 34/59 (57%), Positives = 45/59 (76%)
Query: 1193 KAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRM 1251
K V EAL+KA +GRTCI IAHRLST+++ADLI V G++ E GTH +L++ KG Y+ M
Sbjct: 1212 KVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSM 1270
Score = 68.5 bits (160), Expect = 1e-10
Identities = 33/57 (57%), Positives = 42/57 (73%)
Query: 1195 VTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRM 1251
V AL+KA KGRT I IAHRLSTV++AD+I D G IVE+G H EL+ KG Y+++
Sbjct: 569 VQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKL 625
>BC130424-1|AAI30425.1| 1280|Homo sapiens ATP-binding cassette,
sub-family B (MDR/TAP), member 1 protein.
Length = 1280
Score = 774 bits (1915), Expect = 0.0
Identities = 437/1176 (37%), Positives = 671/1176 (57%), Gaps = 48/1176 (4%)
Query: 18 VSFFQIFRYGNCLELLATALGVVFGMISGAGVCCNLLQIGELSTAFVERTKYHDRLSSYL 77
VS F +FRY N L+ L +G + +I GAG+ +L GE++ F D +S+
Sbjct: 34 VSVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNIT 93
Query: 78 PLTATFGGGKRLVNATHEQNMEALIDDAKAMAIGMFISIGVSLVFCVLSFSLISWSALRQ 137
+ G +N E++M + G+ ++ + + F L+ A RQ
Sbjct: 94 NRSDINDTGF-FMNL--EEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLA-------AGRQ 143
Query: 138 ITRIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVIC 197
I +IR F +++RQ++ W+D L +++++++ I EG+G+K+ + + T
Sbjct: 144 IHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTG 203
Query: 198 LCTAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRT 257
F GW+LTL A+ P +++ + + + +E+ +Y+ AG AEE+L ++RT
Sbjct: 204 FIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRT 263
Query: 258 IVAFGGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVN 317
++AFGG+ KE+ERY + LE A+ G K+ + + G ++L Y+ A+ F YGT LV++
Sbjct: 264 VIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLS 323
Query: 318 DFDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKI 377
+Y +G V ++ FSV + S+ P +E F IF +I+ +P I
Sbjct: 324 G--------EYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSI 375
Query: 378 DSLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKST 437
DS + G P + G++ +V F YPSR EVK+LKG ++ V+ G+ VALVG+SGCGKST
Sbjct: 376 DSYSKSGHKPDNIKGNLEFRNVHFNYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKST 435
Query: 438 VLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEA 497
+QL+QRLYDP G V +LR +GVV QEPVLF TI +NI G
Sbjct: 436 TVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENV 495
Query: 498 TREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLD 557
T +EI++ + A A+DFI LP+ +DT++GERGA LSGGQKQRIAIAR+L+R P +LLLD
Sbjct: 496 TMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLD 555
Query: 558 EATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDL 617
EATSALD SE VQ ALD+A GRTTI ++HRLST+ NAD I D GVIVE+G H++L
Sbjct: 556 EATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDEL 615
Query: 618 MKAKGFYHKLVTTGNENKEPADIEPLIEEADGDGDNIEPTVPSRLDVRRRSSKKVLRHHS 677
MK KG Y KLVT E ++E +E+ + D +E + S ++R S
Sbjct: 616 MKEKGIYFKLVTMQTAGNE-VELENAADESKSEIDALEMS-------SNDSRSSLIRKRS 667
Query: 678 IKKDHPDWLTPRGSISSMVSIGLQNFVFNXXXXXXXXXXXXXTVKTVSDWQLLKLNAPEW 737
++ + RGS + + + + ++ VS W+++KLN EW
Sbjct: 668 TRR------SVRGSQAQDRKLSTKEAL-------------DESIPPVSFWRIMKLNLTEW 708
Query: 738 PLITVGSIAAFLQGACFPVFALLFGFSSGIFI-LDNRDDIIYLADLYSVLFVVIAAVAGI 796
P VG A + G P FA++F G+F +D+ + ++L+S+LF+ + ++ I
Sbjct: 709 PYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFI 768
Query: 797 SMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGA 856
+ LQ TF AG +T RLR+ F S+L+Q++ +FD NT GA+ RL+ D A+V+GA
Sbjct: 769 TFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGA 828
Query: 857 TGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERN 916
G R+ +I Q I+++ G +++ Y W+LTL+ +P++ + +E + + ++
Sbjct: 829 IGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKK 888
Query: 917 AMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVAYKTRWRGLVYGLGVYI 976
+E A IATEA+ + +TV SL E F + +L+ K G+ + +
Sbjct: 889 ELEGAGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAM 948
Query: 977 PFMAYCSATVYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYAPSLNTAKACGARI 1036
+ +Y +GA LVA+ M ++ VLLV A+++GA +GQ +AP AK A I
Sbjct: 949 MYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHI 1008
Query: 1037 LSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTIA 1096
+ II++ P I ++ + GN + +V F YPTRP VL+G+ L+++ G+T+A
Sbjct: 1009 IMIIEKTPLI-DSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLA 1067
Query: 1097 LVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRS 1156
LVGSSGCGKST++QL +RFYDP +G + LD ++I+ L + LR LG+V QEP+L D S
Sbjct: 1068 LVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIK-RLNVQWLRAHLGIVSQEPILFDCS 1126
Query: 1157 LAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP 1192
+AENIAYGDN+R V+ EIV AAK ANIH+FI SLP
Sbjct: 1127 IAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLP 1162
Score = 348 bits (855), Expect = 9e-95
Identities = 196/495 (39%), Positives = 283/495 (57%), Gaps = 14/495 (2%)
Query: 140 RIRTLFLRSVLRQDMSWYDTDSEFN--LASKMSENLMSIKEGMGEKLAVVSNLVGTSVIC 197
R+R + RS+LRQD+SW+D L ++++ + +K +G +LAV++ +
Sbjct: 787 RLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTG 846
Query: 198 LCTAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRT 257
+ +F GWQLTL A++P I + + ++++ + AGK A E +++ RT
Sbjct: 847 IIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRT 906
Query: 258 IVAFGGENKEVERYRRLLE-PAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVV 316
+V+ E K Y + L+ P RK +F G+ F + Y A F +G LV
Sbjct: 907 VVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIF-GITFSFTQAMMYFSYAGCFRFGAYLVA 965
Query: 317 NDFDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPK 376
+ + + V V+S + MA ++ P + I +IE+ P
Sbjct: 966 HKLMSFED-----VLLVFSAVVFGAMAVGQVSSFAPD---YAKAKISAAHIIMIIEKTPL 1017
Query: 377 IDSLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKS 436
IDS +GL P + G++ +V F YP+RP++ VL+G S+ VK G+ +ALVGSSGCGKS
Sbjct: 1018 IDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKS 1077
Query: 437 TVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIG--S 494
TV+QLL+R YDP AG V WLR+ LG+V QEP+LF +I +NIA G S
Sbjct: 1078 TVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNS 1137
Query: 495 PEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVL 554
++EEI R A+ A H FI LPN Y T +G++G LSGGQKQRIAIAR+L+R+P +L
Sbjct: 1138 RVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHIL 1197
Query: 555 LLDEATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTH 614
LLDEATSALD SE+ VQ ALD+A GRT I ++HRLSTI NAD I+ G + E GTH
Sbjct: 1198 LLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTH 1257
Query: 615 EDLMKAKGFYHKLVT 629
+ L+ KG Y +V+
Sbjct: 1258 QQLLAQKGIYFSMVS 1272
Score = 77.0 bits (181), Expect = 4e-13
Identities = 34/59 (57%), Positives = 45/59 (76%)
Query: 1193 KAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRM 1251
K V EAL+KA +GRTCI IAHRLST+++ADLI V G++ E GTH +L++ KG Y+ M
Sbjct: 1212 KVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSM 1270
Score = 68.5 bits (160), Expect = 1e-10
Identities = 33/57 (57%), Positives = 42/57 (73%)
Query: 1195 VTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRM 1251
V AL+KA KGRT I IAHRLSTV++AD+I D G IVE+G H EL+ KG Y+++
Sbjct: 569 VQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKL 625
>M14758-1|AAA59575.1| 1280|Homo sapiens PGY1 protein.
Length = 1280
Score = 772 bits (1908), Expect = 0.0
Identities = 436/1176 (37%), Positives = 670/1176 (56%), Gaps = 48/1176 (4%)
Query: 18 VSFFQIFRYGNCLELLATALGVVFGMISGAGVCCNLLQIGELSTAFVERTKYHDRLSSYL 77
VS F +FRY N L+ L +G + +I GAG+ +L GE++ F D +S+
Sbjct: 34 VSVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNIT 93
Query: 78 PLTATFGGGKRLVNATHEQNMEALIDDAKAMAIGMFISIGVSLVFCVLSFSLISWSALRQ 137
+ G +N E++M + G+ ++ + + F L+ A RQ
Sbjct: 94 NRSDINDTGF-FMNL--EEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLA-------AGRQ 143
Query: 138 ITRIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVIC 197
I +IR F +++RQ++ W+D L +++++++ I E +G+K+ + + T
Sbjct: 144 IHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEVIGDKIGMFFQSMATFFTG 203
Query: 198 LCTAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRT 257
F GW+LTL A+ P +++ + + + +E+ +Y+ AG AEE+L ++RT
Sbjct: 204 FIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRT 263
Query: 258 IVAFGGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVN 317
++AFGG+ KE+ERY + LE A+ G K+ + + G ++L Y+ A+ F YGT LV++
Sbjct: 264 VIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLS 323
Query: 318 DFDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKI 377
+Y +G V ++ FSV + S+ P +E F IF +I+ +P I
Sbjct: 324 G--------EYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSI 375
Query: 378 DSLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKST 437
DS + G P + G++ +V F YPSR EVK+LKG ++ V+ G+ VALVG+SGCGKST
Sbjct: 376 DSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKST 435
Query: 438 VLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEA 497
+QL+QRLYDP G V +LR +GVV QEPVLF TI +NI G
Sbjct: 436 TVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENV 495
Query: 498 TREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLD 557
T +EI++ + A A+DFI LP+ +DT++GERGA LSGGQKQRIAIAR+L+R P +LLLD
Sbjct: 496 TMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLD 555
Query: 558 EATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDL 617
EATSALD SE VQ ALD+A GRTTI ++HRLST+ NAD I D GVIVE+G H++L
Sbjct: 556 EATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDEL 615
Query: 618 MKAKGFYHKLVTTGNENKEPADIEPLIEEADGDGDNIEPTVPSRLDVRRRSSKKVLRHHS 677
MK KG Y KLVT E ++E +E+ + D +E + S ++R S
Sbjct: 616 MKEKGIYFKLVTMQTAGNE-VELENAADESKSEIDALEMS-------SNDSRSSLIRKRS 667
Query: 678 IKKDHPDWLTPRGSISSMVSIGLQNFVFNXXXXXXXXXXXXXTVKTVSDWQLLKLNAPEW 737
++ + RGS + + + + ++ VS W+++KLN EW
Sbjct: 668 TRR------SVRGSQAQDRKLSTKEAL-------------DESIPPVSFWRIMKLNLTEW 708
Query: 738 PLITVGSIAAFLQGACFPVFALLFGFSSGIFI-LDNRDDIIYLADLYSVLFVVIAAVAGI 796
P VG A + G P FA++F G+F +D+ + ++L+S+LF+ + ++ I
Sbjct: 709 PYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFI 768
Query: 797 SMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGA 856
+ LQ TF AG +T RLR+ F S+L+Q++ +FD NT GA+ RL+ D A+V+GA
Sbjct: 769 TFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGA 828
Query: 857 TGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERN 916
G R+ +I Q I+++ G +++ Y W+LTL+ +P++ + +E + + ++
Sbjct: 829 IGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKK 888
Query: 917 AMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVAYKTRWRGLVYGLGVYI 976
+E A IATEA+ + +TV SL E F + +L+ K G+ + +
Sbjct: 889 ELEGAGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAM 948
Query: 977 PFMAYCSATVYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYAPSLNTAKACGARI 1036
+ +Y +GA LVA+ M ++ VLLV A+++GA +GQ +AP AK A I
Sbjct: 949 MYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHI 1008
Query: 1037 LSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTIA 1096
+ II++ P I ++ + GN + +V F YPTRP VL+G+ L+++ G+T+A
Sbjct: 1009 IMIIEKTPLI-DSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLA 1067
Query: 1097 LVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRS 1156
LVGSSGCGKST++QL +RFYDP +G + LD ++I+ L + LR LG+V QEP+L D S
Sbjct: 1068 LVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIK-RLNVQWLRAHLGIVSQEPILFDCS 1126
Query: 1157 LAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP 1192
+AENIAYGDN+R V+ EIV AAK ANIH+FI SLP
Sbjct: 1127 IAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLP 1162
Score = 348 bits (855), Expect = 9e-95
Identities = 196/495 (39%), Positives = 283/495 (57%), Gaps = 14/495 (2%)
Query: 140 RIRTLFLRSVLRQDMSWYDTDSEFN--LASKMSENLMSIKEGMGEKLAVVSNLVGTSVIC 197
R+R + RS+LRQD+SW+D L ++++ + +K +G +LAV++ +
Sbjct: 787 RLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTG 846
Query: 198 LCTAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRT 257
+ +F GWQLTL A++P I + + ++++ + AGK A E +++ RT
Sbjct: 847 IIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRT 906
Query: 258 IVAFGGENKEVERYRRLLE-PAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVV 316
+V+ E K Y + L+ P RK +F G+ F + Y A F +G LV
Sbjct: 907 VVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIF-GITFSFTQAMMYFSYAGCFRFGAYLVA 965
Query: 317 NDFDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPK 376
+ + + V V+S + MA ++ P + I +IE+ P
Sbjct: 966 HKLMSFED-----VLLVFSAVVFGAMAVGQVSSFAPD---YAKAKISAAHIIMIIEKTPL 1017
Query: 377 IDSLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKS 436
IDS +GL P + G++ +V F YP+RP++ VL+G S+ VK G+ +ALVGSSGCGKS
Sbjct: 1018 IDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKS 1077
Query: 437 TVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIG--S 494
TV+QLL+R YDP AG V WLR+ LG+V QEP+LF +I +NIA G S
Sbjct: 1078 TVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNS 1137
Query: 495 PEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVL 554
++EEI R A+ A H FI LPN Y T +G++G LSGGQKQRIAIAR+L+R+P +L
Sbjct: 1138 RVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHIL 1197
Query: 555 LLDEATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTH 614
LLDEATSALD SE+ VQ ALD+A GRT I ++HRLSTI NAD I+ G + E GTH
Sbjct: 1198 LLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTH 1257
Query: 615 EDLMKAKGFYHKLVT 629
+ L+ KG Y +V+
Sbjct: 1258 QQLLAQKGIYFSMVS 1272
Score = 77.0 bits (181), Expect = 4e-13
Identities = 34/59 (57%), Positives = 45/59 (76%)
Query: 1193 KAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRM 1251
K V EAL+KA +GRTCI IAHRLST+++ADLI V G++ E GTH +L++ KG Y+ M
Sbjct: 1212 KVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSM 1270
Score = 68.5 bits (160), Expect = 1e-10
Identities = 33/57 (57%), Positives = 42/57 (73%)
Query: 1195 VTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRM 1251
V AL+KA KGRT I IAHRLSTV++AD+I D G IVE+G H EL+ KG Y+++
Sbjct: 569 VQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKL 625
>AF016535-1|AAB69423.1| 1279|Homo sapiens P-glycoprotein protein.
Length = 1279
Score = 771 bits (1906), Expect = 0.0
Identities = 437/1176 (37%), Positives = 671/1176 (57%), Gaps = 49/1176 (4%)
Query: 18 VSFFQIFRYGNCLELLATALGVVFGMISGAGVCCNLLQIGELSTAFVERTKYHDRLSSYL 77
VS F +FRY N L+ L +G + +I GAG+ +L GE++ F D +S+
Sbjct: 34 VSVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNIT 93
Query: 78 PLTATFGGGKRLVNATHEQNMEALIDDAKAMAIGMFISIGVSLVFCVLSFSLISWSALRQ 137
+ G +N E++M + G+ ++ + + F L+ A RQ
Sbjct: 94 NRSDINDTGF-FMNL--EEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLA-------AGRQ 143
Query: 138 ITRIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVIC 197
I +IR F +++RQ++ W+D L +++++++ I EG+G+K+ + + T
Sbjct: 144 IHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTG 203
Query: 198 LCTAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRT 257
F GW+LTL A+ P +++ + + + +E+ +Y+ AG AEE+L ++RT
Sbjct: 204 FIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRT 263
Query: 258 IVAFGGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVN 317
++AFGG+ KE+ERY + LE A+ G K+ + + G ++L Y+ A+ F YGT LV++
Sbjct: 264 VIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLS 323
Query: 318 DFDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKI 377
+Y +G V ++ FSV + S+ P +E F IF +I+ +P I
Sbjct: 324 G--------EYSIGQVLTV-FSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSI 374
Query: 378 DSLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKST 437
DS + G P + G++ +V F YPSR EVK+LKG ++ V+ G+ VALVG+SGCGKST
Sbjct: 375 DSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKST 434
Query: 438 VLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEA 497
+QL+QRLYDP G V +LR +GVV QEPVLF TI +NI G
Sbjct: 435 TVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENV 494
Query: 498 TREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLD 557
T +EI++ + A A+DFI LP+ +DT++GERGA LSGGQKQRIAIAR+L+R P +LLLD
Sbjct: 495 TMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLD 554
Query: 558 EATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDL 617
EATSALD SE VQ ALD+A GRTTI ++HRLST+ NAD I D GVIVE+G H++L
Sbjct: 555 EATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDEL 614
Query: 618 MKAKGFYHKLVTTGNENKEPADIEPLIEEADGDGDNIEPTVPSRLDVRRRSSKKVLRHHS 677
MK KG Y KLVT E ++E +E+ + D +E + S ++R S
Sbjct: 615 MKEKGIYFKLVTMQTAGNE-VELENAADESKSEIDALEMS-------SNDSRSSLIRKRS 666
Query: 678 IKKDHPDWLTPRGSISSMVSIGLQNFVFNXXXXXXXXXXXXXTVKTVSDWQLLKLNAPEW 737
++ + RGS + + + + ++ VS W+++KLN EW
Sbjct: 667 TRR------SVRGSQAQDRKLSTKEAL-------------DESIPPVSFWRIMKLNLTEW 707
Query: 738 PLITVGSIAAFLQGACFPVFALLFGFSSGIFI-LDNRDDIIYLADLYSVLFVVIAAVAGI 796
P VG A + G P FA++F G+F +D+ + ++L+S+LF+ + ++ I
Sbjct: 708 PYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFI 767
Query: 797 SMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGA 856
+ LQ TF AG +T RLR+ F S+L+Q++ +FD NT GA+ RL+ D A+V+GA
Sbjct: 768 TFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGA 827
Query: 857 TGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERN 916
G R+ +I Q I+++ G +++ Y W+LTL+ +P++ + +E + + ++
Sbjct: 828 IGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKK 887
Query: 917 AMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVAYKTRWRGLVYGLGVYI 976
+E A IATEA+ + +TV SL E F + +L+ K G+ + +
Sbjct: 888 ELEGAGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAM 947
Query: 977 PFMAYCSATVYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYAPSLNTAKACGARI 1036
+ +Y +GA LVA+ M ++ VLLV A+++GA +GQ +AP AK A I
Sbjct: 948 MYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHI 1007
Query: 1037 LSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTIA 1096
+ II++ P I ++ + GN + +V F YPTRP VL+G+ L+++ G+T+A
Sbjct: 1008 IMIIEKTPLI-DSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLA 1066
Query: 1097 LVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRS 1156
LVGSSGCGKST++QL +RFYDP +G + LD ++I+ L + LR LG+V QEP+L D S
Sbjct: 1067 LVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIK-RLNVQWLRAHLGIVSQEPILFDCS 1125
Query: 1157 LAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP 1192
+AENIAYGDN+R V+ EIV AAK ANIH+FI SLP
Sbjct: 1126 IAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLP 1161
Score = 348 bits (855), Expect = 9e-95
Identities = 196/495 (39%), Positives = 283/495 (57%), Gaps = 14/495 (2%)
Query: 140 RIRTLFLRSVLRQDMSWYDTDSEFN--LASKMSENLMSIKEGMGEKLAVVSNLVGTSVIC 197
R+R + RS+LRQD+SW+D L ++++ + +K +G +LAV++ +
Sbjct: 786 RLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTG 845
Query: 198 LCTAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRT 257
+ +F GWQLTL A++P I + + ++++ + AGK A E +++ RT
Sbjct: 846 IIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRT 905
Query: 258 IVAFGGENKEVERYRRLLE-PAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVV 316
+V+ E K Y + L+ P RK +F G+ F + Y A F +G LV
Sbjct: 906 VVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIF-GITFSFTQAMMYFSYAGCFRFGAYLVA 964
Query: 317 NDFDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPK 376
+ + + V V+S + MA ++ P + I +IE+ P
Sbjct: 965 HKLMSFED-----VLLVFSAVVFGAMAVGQVSSFAPD---YAKAKISAAHIIMIIEKTPL 1016
Query: 377 IDSLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKS 436
IDS +GL P + G++ +V F YP+RP++ VL+G S+ VK G+ +ALVGSSGCGKS
Sbjct: 1017 IDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKS 1076
Query: 437 TVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIG--S 494
TV+QLL+R YDP AG V WLR+ LG+V QEP+LF +I +NIA G S
Sbjct: 1077 TVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNS 1136
Query: 495 PEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVL 554
++EEI R A+ A H FI LPN Y T +G++G LSGGQKQRIAIAR+L+R+P +L
Sbjct: 1137 RVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHIL 1196
Query: 555 LLDEATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTH 614
LLDEATSALD SE+ VQ ALD+A GRT I ++HRLSTI NAD I+ G + E GTH
Sbjct: 1197 LLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTH 1256
Query: 615 EDLMKAKGFYHKLVT 629
+ L+ KG Y +V+
Sbjct: 1257 QQLLAQKGIYFSMVS 1271
Score = 77.0 bits (181), Expect = 4e-13
Identities = 34/59 (57%), Positives = 45/59 (76%)
Query: 1193 KAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRM 1251
K V EAL+KA +GRTCI IAHRLST+++ADLI V G++ E GTH +L++ KG Y+ M
Sbjct: 1211 KVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSM 1269
Score = 68.5 bits (160), Expect = 1e-10
Identities = 33/57 (57%), Positives = 42/57 (73%)
Query: 1195 VTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRM 1251
V AL+KA KGRT I IAHRLSTV++AD+I D G IVE+G H EL+ KG Y+++
Sbjct: 568 VQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKL 624
>AB208970-1|BAD92207.1| 1062|Homo sapiens Multidrug resistance protein
1 variant protein.
Length = 1062
Score = 701 bits (1733), Expect = 0.0
Identities = 386/980 (39%), Positives = 578/980 (58%), Gaps = 38/980 (3%)
Query: 214 AVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAFGGENKEVERYRR 273
A+ P +++ + + + +E+ +Y+ AG AEE+L ++RT++AFGG+ KE+ERY +
Sbjct: 2 AISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNK 61
Query: 274 LLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAV 333
LE A+ G K+ + + G ++L Y+ A+ F YGT LV++ +Y +G V
Sbjct: 62 NLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSG--------EYSIGQV 113
Query: 334 YSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPRRVVGD 393
++ FSV + S+ P +E F IF +I+ +P IDS + G P + G+
Sbjct: 114 LTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGN 173
Query: 394 ILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSV 453
+ +V F YPSR EVK+LKG ++ V+ G+ VALVG+SGCGKST +QL+QRLYDP G V
Sbjct: 174 LEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMV 233
Query: 454 XXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHD 513
+LR +GVV QEPVLF TI +NI G T +EI++ + A A+D
Sbjct: 234 SVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYD 293
Query: 514 FISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQA 573
FI LP+ +DT++GERGA LSGGQKQRIAIAR+L+R P +LLLDEATSALD SE VQ
Sbjct: 294 FIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQV 353
Query: 574 ALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNE 633
ALD+A GRTTI ++HRLST+ NAD I D GVIVE+G H++LMK KG Y KLVT
Sbjct: 354 ALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTA 413
Query: 634 NKEPADIEPLIEEADGDGDNIEPTVPSRLDVRRRSSKKVLRHHSIKKDHPDWLTPRGSIS 693
E ++E +E+ + D +E + S ++R S ++ + RGS +
Sbjct: 414 GNE-VELENAADESKSEIDALEMS-------SNDSRSSLIRKRSTRR------SVRGSQA 459
Query: 694 SMVSIGLQNFVFNXXXXXXXXXXXXXTVKTVSDWQLLKLNAPEWPLITVGSIAAFLQGAC 753
+ + + ++ VS W+++KLN EWP VG A + G
Sbjct: 460 QDRKLSTKEAL-------------DESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGL 506
Query: 754 FPVFALLFGFSSGIFI-LDNRDDIIYLADLYSVLFVVIAAVAGISMCLQSTTFTSAGLKM 812
P FA++F G+F +D+ + ++L+S+LF+ + ++ I+ LQ TF AG +
Sbjct: 507 QPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEIL 566
Query: 813 TTRLRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVV 872
T RLR+ F S+L+Q++ +FD NT GA+ RL+ D A+V+GA G R+ +I Q I+++
Sbjct: 567 TKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLG 626
Query: 873 VGFLLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVSI 932
G +++ Y W+LTL+ +P++ + +E + + ++ +E A IATEA+ +
Sbjct: 627 TGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENF 686
Query: 933 KTVQSLGVETVFLQKFQDALKTACVAVAYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLV 992
+TV SL E F + +L+ K G+ + + + +Y +GA LV
Sbjct: 687 RTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLV 746
Query: 993 AYGEMEYKLVLLVNEAIMYGAYMLGQSLVYAPSLNTAKACGARILSIIQRQPKIHNAVGV 1052
A+ M ++ VLLV A+++GA +GQ +AP AK A I+ II++ P I ++
Sbjct: 747 AHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLI-DSYST 805
Query: 1053 KDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLF 1112
+ GN + +V F YPTRP VL+G+ L+++ G+T+ALVGSSGCGKST++QL
Sbjct: 806 EGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLL 865
Query: 1113 QRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTM 1172
+RFYDP +G + LD ++I+ L + LR LG+V QEP+L D S+AENIAYGDN+R V+
Sbjct: 866 ERFYDPLAGKVLLDGKEIK-RLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQ 924
Query: 1173 HEIVAAAKAANIHSFIVSLP 1192
EIV AAK ANIH+FI SLP
Sbjct: 925 EEIVRAAKEANIHAFIESLP 944
Score = 348 bits (855), Expect = 9e-95
Identities = 196/495 (39%), Positives = 283/495 (57%), Gaps = 14/495 (2%)
Query: 140 RIRTLFLRSVLRQDMSWYDTDSEFN--LASKMSENLMSIKEGMGEKLAVVSNLVGTSVIC 197
R+R + RS+LRQD+SW+D L ++++ + +K +G +LAV++ +
Sbjct: 569 RLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTG 628
Query: 198 LCTAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRT 257
+ +F GWQLTL A++P I + + ++++ + AGK A E +++ RT
Sbjct: 629 IIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIATEAIENFRT 688
Query: 258 IVAFGGENKEVERYRRLLE-PAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVV 316
+V+ E K Y + L+ P RK +F G+ F + Y A F +G LV
Sbjct: 689 VVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIF-GITFSFTQAMMYFSYAGCFRFGAYLVA 747
Query: 317 NDFDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPK 376
+ + + V V+S + MA ++ P + I +IE+ P
Sbjct: 748 HKLMSFED-----VLLVFSAVVFGAMAVGQVSSFAPD---YAKAKISAAHIIMIIEKTPL 799
Query: 377 IDSLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKS 436
IDS +GL P + G++ +V F YP+RP++ VL+G S+ VK G+ +ALVGSSGCGKS
Sbjct: 800 IDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKS 859
Query: 437 TVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIG--S 494
TV+QLL+R YDP AG V WLR+ LG+V QEP+LF +I +NIA G S
Sbjct: 860 TVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNS 919
Query: 495 PEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVL 554
++EEI R A+ A H FI LPN Y T +G++G LSGGQKQRIAIAR+L+R+P +L
Sbjct: 920 RVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHIL 979
Query: 555 LLDEATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTH 614
LLDEATSALD SE+ VQ ALD+A GRT I ++HRLSTI NAD I+ G + E GTH
Sbjct: 980 LLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTH 1039
Query: 615 EDLMKAKGFYHKLVT 629
+ L+ KG Y +V+
Sbjct: 1040 QQLLAQKGIYFSMVS 1054
Score = 77.0 bits (181), Expect = 4e-13
Identities = 34/59 (57%), Positives = 45/59 (76%)
Query: 1193 KAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRM 1251
K V EAL+KA +GRTCI IAHRLST+++ADLI V G++ E GTH +L++ KG Y+ M
Sbjct: 994 KVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSM 1052
Score = 68.5 bits (160), Expect = 1e-10
Identities = 33/57 (57%), Positives = 42/57 (73%)
Query: 1195 VTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRM 1251
V AL+KA KGRT I IAHRLSTV++AD+I D G IVE+G H EL+ KG Y+++
Sbjct: 351 VQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKL 407
>M23234-1|AAA36207.1| 1279|Homo sapiens protein ( Human membrane
glycoprotein P (mdr3) mRNA, complete cds. ).
Length = 1279
Score = 448 bits (1104), Expect = e-125
Identities = 238/613 (38%), Positives = 363/613 (59%), Gaps = 24/613 (3%)
Query: 17 LVSFFQIFRYGNCLELLATALGVVFGMISGAGVCCNLLQIGELSTAFVERT-KYHDRLSS 75
++ +FRY + + L +LG + + G+G+ ++ GE++ FV+ + ++
Sbjct: 39 MIGVLTLFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNF 98
Query: 76 YLPLTATFGGGKRLVNATHEQNMEALIDDAKAMAIGMFISIGVSLVFCVLSFSLISWSAL 135
L L GK L E+ M + G+ ++ + + F L +A
Sbjct: 99 SLSL---LNPGKIL-----EEEMTRYAYYYSGLGAGVLVAAYIQVSFWTL-------AAG 143
Query: 136 RQITRIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSV 195
RQI +IR F ++LRQ++ W+D + L +++++++ I EG+G+K+ + V T
Sbjct: 144 RQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFF 203
Query: 196 ICLCTAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSV 255
F GW+LTL A+ P +++ + + S +E+ +Y+ AG AEE L ++
Sbjct: 204 AGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAI 263
Query: 256 RTIVAFGGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLV 315
RT++AFGG+NKE+ERY++ LE A+E G K+ + + G ++L Y+ A+ F YG+ LV
Sbjct: 264 RTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLV 323
Query: 316 VNDFDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREP 375
++ ++Y +G ++ FS+ + S+ P ++ F IF +I+ P
Sbjct: 324 IS--------KEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNP 375
Query: 376 KIDSLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGK 435
KIDS ++G P + G++ DV F YPSR VK+LKG ++ V+ G+ VALVGSSGCGK
Sbjct: 376 KIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGK 435
Query: 436 STVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSP 495
ST +QL+QRLYDP G++ ++LR +GVV QEPVLF TI +NI G
Sbjct: 436 STTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRG 495
Query: 496 EATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLL 555
T +EI++ + A A++FI LP +DT++GERGA LSGGQKQRIAIAR+L+R P +LL
Sbjct: 496 NVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILL 555
Query: 556 LDEATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHE 615
LDEATSALD SE +VQAALD+A GRTTI ++HRLST+ NAD I + GVIVEQG+H
Sbjct: 556 LDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHS 615
Query: 616 DLMKAKGFYHKLV 628
+LMK +G Y KLV
Sbjct: 616 ELMKKEGVYFKLV 628
Score = 345 bits (848), Expect = 6e-94
Identities = 196/503 (38%), Positives = 291/503 (57%), Gaps = 18/503 (3%)
Query: 140 RIRTLFLRSVLRQDMSWYDT--DSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVIC 197
R+R++ +++LRQDMSW+D +S L+++++ + ++ G +LA+++ +
Sbjct: 786 RLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTG 845
Query: 198 LCTAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRT 257
+ +F GWQLTL AV+P ++ I ++ R+ + AGK A E ++++RT
Sbjct: 846 IIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRT 905
Query: 258 IVAFGGENKEVERY-RRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVV 316
+V+ E K Y +L P +K ++ G+ + Y A F +G L+V
Sbjct: 906 VVSLTQERKFESMYVEKLYGPYRNSVQKAHIY-GITFSISQAFMYFSYAGCFRFGAYLIV 964
Query: 317 NDFDTDSNLRQYPVGAVYS-ILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREP 375
N ++R V V+S I+F + +F + +F L ER+P
Sbjct: 965 N-----GHMRFRDVILVFSAIVFGAVALGHASSFA----PDYAKAKLSAAHLFMLFERQP 1015
Query: 376 KIDSLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGK 435
IDS ++GL P + G+I +V F YP+R V VL+G S+ VK G+ +ALVGSSGCGK
Sbjct: 1016 LIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGK 1075
Query: 436 STVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIG-- 493
STV+QLL+R YDP AG+V WLR+ LG+V QEP+LF +I +NIA G
Sbjct: 1076 STVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDN 1135
Query: 494 SPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAV 553
S +++EI A+ A H FI LP+ Y+T +G++G LSGGQKQRIAIAR+L+R+P +
Sbjct: 1136 SRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQI 1195
Query: 554 LLLDEATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGT 613
LLLDEATSALD SE+ VQ ALD+A GRT I ++HRLSTI NAD I+ G + E GT
Sbjct: 1196 LLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGT 1255
Query: 614 HEDLMKAKGFYHKLVT--TGNEN 634
H+ L+ KG Y +V+ G +N
Sbjct: 1256 HQQLLAQKGIYFSMVSVQAGTQN 1278
Score = 338 bits (831), Expect = 7e-92
Identities = 187/477 (39%), Positives = 287/477 (60%), Gaps = 12/477 (2%)
Query: 721 VKTVSDWQLLKLNAPEWPLITVGSIAAFLQGACFPVFALLFGFSSGIFILDNRDDII--Y 778
V VS ++LKLN EWP VG++ A G P F+++F S I I DD +
Sbjct: 692 VPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIF--SEIIAIFGPGDDAVKQQ 749
Query: 779 LADLYSVLFVVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNT 838
+++S++F+ + ++ + LQ TF AG +T RLR F ++L+Q++ +FD N+
Sbjct: 750 KCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNS 809
Query: 839 VGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLM-V 897
GA+ RL+ D A+VQGATG R+ LI Q I+++ G +++ Y W+LTL+ +P++ V
Sbjct: 810 TGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAV 869
Query: 898 GSIWLEGIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACV 957
I +++ A+ D++ +E+A IATEA+ +I+TV SL E F + + L
Sbjct: 870 SGIVEMKLLAGNAKRDKKE-LEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYR 928
Query: 958 AVAYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLG 1017
K G+ + + + +Y +GA L+ G M ++ V+LV AI++GA LG
Sbjct: 929 NSVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALG 988
Query: 1018 QSLVYAPSLNTAKACGARILSIIQRQPKI--HNAVGVKDKKDWVASGNFSMRDVEFCYPT 1075
+ +AP AK A + + +RQP I ++ G+K K GN + +V F YPT
Sbjct: 989 HASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDK---FEGNITFNEVVFNYPT 1045
Query: 1076 RPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALT 1135
R + VL+G+ L+++ G+T+ALVGSSGCGKST++QL +RFYDP +G + LD ++ + L
Sbjct: 1046 RANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKK-LN 1104
Query: 1136 IPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP 1192
+ LR QLG+V QEP+L D S+AENIAYGDN+R V+ EIV+AAKAANIH FI +LP
Sbjct: 1105 VQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLP 1161
Score = 243 bits (595), Expect = 3e-63
Identities = 143/413 (34%), Positives = 228/413 (55%), Gaps = 10/413 (2%)
Query: 783 YSVLFVVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAI 842
Y+ + + A ++ +Q + +T A + ++R ++F ++L+QEIG+FD N +
Sbjct: 116 YAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFD--INDTTEL 173
Query: 843 CARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLM--VGSI 900
RL+ D +++ G ++G+ Q +++ GF++ WKLTLV P++ ++
Sbjct: 174 NTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAV 233
Query: 901 WLEGIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVA 960
W + I+S + E A A A+A EA+ +I+TV + G + L+++Q L+ A
Sbjct: 234 WAK-ILSAFSD-KELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGI 291
Query: 961 YKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSL 1020
K + G+ + + +Y A YG+ LV E + V +I+ GA+ +GQ+
Sbjct: 292 KKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAA 351
Query: 1021 VYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQR 1080
+ A+ I II PKI + K D + GN DV F YP+R + +
Sbjct: 352 PCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSI-KGNLEFNDVHFSYPSRANVK 410
Query: 1081 VLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLR 1140
+LKG++LK+++G+T+ALVGSSGCGKST +QL QR YDPD G I +D +DIR+ + LR
Sbjct: 411 ILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRN-FNVNYLR 469
Query: 1141 RQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPK 1193
+GVV QEPVL ++AENI YG N VTM EI A K AN + FI+ LP+
Sbjct: 470 EIIGVVSQEPVLFSTTIAENICYGRGN--VTMDEIKKAVKEANAYEFIMKLPQ 520
Score = 77.0 bits (181), Expect = 4e-13
Identities = 34/59 (57%), Positives = 45/59 (76%)
Query: 1193 KAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRM 1251
K V EAL+KA +GRTCI IAHRLST+++ADLI V G++ E GTH +L++ KG Y+ M
Sbjct: 1211 KVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSM 1269
Score = 66.1 bits (154), Expect = 8e-10
Identities = 31/61 (50%), Positives = 45/61 (73%)
Query: 1195 VTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRMCRG 1254
V AL+KA +GRT I IAHRLSTV++AD+I + G IVE+G+H+EL+ +G Y+++
Sbjct: 571 VQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNM 630
Query: 1255 Q 1255
Q
Sbjct: 631 Q 631
>EF034088-1|ABJ53424.1| 1286|Homo sapiens ATP-binding cassette,
sub-family B (MDR/TAP), member 4 protein.
Length = 1286
Score = 448 bits (1104), Expect = e-125
Identities = 238/613 (38%), Positives = 363/613 (59%), Gaps = 24/613 (3%)
Query: 17 LVSFFQIFRYGNCLELLATALGVVFGMISGAGVCCNLLQIGELSTAFVERT-KYHDRLSS 75
++ +FRY + + L +LG + + G+G+ ++ GE++ FV+ + ++
Sbjct: 39 MIGVLTLFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNF 98
Query: 76 YLPLTATFGGGKRLVNATHEQNMEALIDDAKAMAIGMFISIGVSLVFCVLSFSLISWSAL 135
L L GK L E+ M + G+ ++ + + F L +A
Sbjct: 99 SLSL---LNPGKIL-----EEEMTRYAYYYSGLGAGVLVAAYIQVSFWTL-------AAG 143
Query: 136 RQITRIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSV 195
RQI +IR F ++LRQ++ W+D + L +++++++ I EG+G+K+ + V T
Sbjct: 144 RQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFF 203
Query: 196 ICLCTAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSV 255
F GW+LTL A+ P +++ + + S +E+ +Y+ AG AEE L ++
Sbjct: 204 AGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAI 263
Query: 256 RTIVAFGGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLV 315
RT++AFGG+NKE+ERY++ LE A+E G K+ + + G ++L Y+ A+ F YG+ LV
Sbjct: 264 RTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLV 323
Query: 316 VNDFDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREP 375
++ ++Y +G ++ FS+ + S+ P ++ F IF +I+ P
Sbjct: 324 IS--------KEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNP 375
Query: 376 KIDSLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGK 435
KIDS ++G P + G++ DV F YPSR VK+LKG ++ V+ G+ VALVGSSGCGK
Sbjct: 376 KIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGK 435
Query: 436 STVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSP 495
ST +QL+QRLYDP G++ ++LR +GVV QEPVLF TI +NI G
Sbjct: 436 STTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRG 495
Query: 496 EATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLL 555
T +EI++ + A A++FI LP +DT++GERGA LSGGQKQRIAIAR+L+R P +LL
Sbjct: 496 NVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILL 555
Query: 556 LDEATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHE 615
LDEATSALD SE +VQAALD+A GRTTI ++HRLST+ NAD I + GVIVEQG+H
Sbjct: 556 LDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHS 615
Query: 616 DLMKAKGFYHKLV 628
+LMK +G Y KLV
Sbjct: 616 ELMKKEGVYFKLV 628
Score = 336 bits (825), Expect = 4e-91
Identities = 196/510 (38%), Positives = 291/510 (57%), Gaps = 25/510 (4%)
Query: 140 RIRTLFLRSVLRQDMSWYDT--DSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVIC 197
R+R++ +++LRQDMSW+D +S L+++++ + ++ G +LA+++ +
Sbjct: 786 RLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTG 845
Query: 198 LCTAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRT 257
+ +F GWQLTL AV+P ++ I ++ R+ + AGK A E ++++RT
Sbjct: 846 IIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRT 905
Query: 258 IVAFGGENKEVERY-RRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVV 316
+V+ E K Y +L P +K ++ G+ + Y A F +G L+V
Sbjct: 906 VVSLTQERKFESMYVEKLYGPYRNSVQKAHIY-GITFSISQAFMYFSYAGCFRFGAYLIV 964
Query: 317 NDFDTDSNLRQYPVGAVYS-ILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREP 375
N ++R V V+S I+F + +F + +F L ER+P
Sbjct: 965 N-----GHMRFRDVILVFSAIVFGAVALGHASSFA----PDYAKAKLSAAHLFMLFERQP 1015
Query: 376 KIDSLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGK 435
IDS ++GL P + G+I +V F YP+R V VL+G S+ VK G+ +ALVGSSGCGK
Sbjct: 1016 LIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGK 1075
Query: 436 STVLQLLQRLYDPQAGSVXXXXXX-------XXXXXXSWLRSSLGVVGQEPVLFRGTIYD 488
STV+QLL+R YDP AG+V WLR+ LG+V QEP+LF +I +
Sbjct: 1076 STVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAE 1135
Query: 489 NIAIG--SPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARS 546
NIA G S +++EI A+ A H FI LP+ Y+T +G++G LSGGQKQRIAIAR+
Sbjct: 1136 NIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARA 1195
Query: 547 LLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQG 606
L+R+P +LLLDEATSALD SE+ VQ ALD+A GRT I ++HRLSTI NAD I+ G
Sbjct: 1196 LIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNG 1255
Query: 607 VIVEQGTHEDLMKAKGFYHKLVT--TGNEN 634
+ E GTH+ L+ KG Y +V+ G +N
Sbjct: 1256 RVKEHGTHQQLLAQKGIYFSMVSVQAGTQN 1285
Score = 332 bits (817), Expect = 3e-90
Identities = 189/484 (39%), Positives = 287/484 (59%), Gaps = 19/484 (3%)
Query: 721 VKTVSDWQLLKLNAPEWPLITVGSIAAFLQGACFPVFALLFGFSSGIFILDNRDDII--Y 778
V VS ++LKLN EWP VG++ A G P F+++F S I I DD +
Sbjct: 692 VPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIF--SEIIAIFGPGDDAVKQQ 749
Query: 779 LADLYSVLFVVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNT 838
+++S++F+ + ++ + LQ TF AG +T RLR F ++L+Q++ +FD N+
Sbjct: 750 KCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNS 809
Query: 839 VGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLM-V 897
GA+ RL+ D A+VQGATG R+ LI Q I+++ G +++ Y W+LTL+ +P++ V
Sbjct: 810 TGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAV 869
Query: 898 GSIWLEGIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACV 957
I +++ A+ D++ +E+A IATEA+ +I+TV SL E F + + L
Sbjct: 870 SGIVEMKLLAGNAKRDKKE-LEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYR 928
Query: 958 AVAYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLG 1017
K G+ + + + +Y +GA L+ G M ++ V+LV AI++GA LG
Sbjct: 929 NSVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALG 988
Query: 1018 QSLVYAPSLNTAKACGARILSIIQRQPKI--HNAVGVKDKKDWVASGNFSMRDVEFCYPT 1075
+ +AP AK A + + +RQP I ++ G+K K GN + +V F YPT
Sbjct: 989 HASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDK---FEGNITFNEVVFNYPT 1045
Query: 1076 RPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDP-------DSGFIELDNR 1128
R + VL+G+ L+++ G+T+ALVGSSGCGKST++QL +RFYDP D GF LD +
Sbjct: 1046 RANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQ 1105
Query: 1129 DIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFI 1188
+ + L + LR QLG+V QEP+L D S+AENIAYGDN+R V+ EIV+AAKAANIH FI
Sbjct: 1106 EAKK-LNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFI 1164
Query: 1189 VSLP 1192
+LP
Sbjct: 1165 ETLP 1168
Score = 243 bits (595), Expect = 3e-63
Identities = 143/413 (34%), Positives = 228/413 (55%), Gaps = 10/413 (2%)
Query: 783 YSVLFVVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAI 842
Y+ + + A ++ +Q + +T A + ++R ++F ++L+QEIG+FD N +
Sbjct: 116 YAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFD--INDTTEL 173
Query: 843 CARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLM--VGSI 900
RL+ D +++ G ++G+ Q +++ GF++ WKLTLV P++ ++
Sbjct: 174 NTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAV 233
Query: 901 WLEGIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVA 960
W + I+S + E A A A+A EA+ +I+TV + G + L+++Q L+ A
Sbjct: 234 WAK-ILSAFSD-KELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGI 291
Query: 961 YKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSL 1020
K + G+ + + +Y A YG+ LV E + V +I+ GA+ +GQ+
Sbjct: 292 KKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAA 351
Query: 1021 VYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQR 1080
+ A+ I II PKI + K D + GN DV F YP+R + +
Sbjct: 352 PCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSI-KGNLEFNDVHFSYPSRANVK 410
Query: 1081 VLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLR 1140
+LKG++LK+++G+T+ALVGSSGCGKST +QL QR YDPD G I +D +DIR+ + LR
Sbjct: 411 ILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRN-FNVNYLR 469
Query: 1141 RQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPK 1193
+GVV QEPVL ++AENI YG N VTM EI A K AN + FI+ LP+
Sbjct: 470 EIIGVVSQEPVLFSTTIAENICYGRGN--VTMDEIKKAVKEANAYEFIMKLPQ 520
Score = 77.0 bits (181), Expect = 4e-13
Identities = 34/59 (57%), Positives = 45/59 (76%)
Query: 1193 KAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRM 1251
K V EAL+KA +GRTCI IAHRLST+++ADLI V G++ E GTH +L++ KG Y+ M
Sbjct: 1218 KVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSM 1276
Score = 66.1 bits (154), Expect = 8e-10
Identities = 31/61 (50%), Positives = 45/61 (73%)
Query: 1195 VTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRMCRG 1254
V AL+KA +GRT I IAHRLSTV++AD+I + G IVE+G+H+EL+ +G Y+++
Sbjct: 571 VQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNM 630
Query: 1255 Q 1255
Q
Sbjct: 631 Q 631
>BC042531-1|AAH42531.1| 1286|Homo sapiens ATP-binding cassette,
sub-family B (MDR/TAP), member 4 protein.
Length = 1286
Score = 446 bits (1100), Expect = e-124
Identities = 238/613 (38%), Positives = 362/613 (59%), Gaps = 24/613 (3%)
Query: 17 LVSFFQIFRYGNCLELLATALGVVFGMISGAGVCCNLLQIGELSTAFVERT-KYHDRLSS 75
++ +FRY + + L +LG + + G+G+ ++ GE++ FV+ + ++
Sbjct: 39 MIGVLTLFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNF 98
Query: 76 YLPLTATFGGGKRLVNATHEQNMEALIDDAKAMAIGMFISIGVSLVFCVLSFSLISWSAL 135
L L GK L E+ M + G+ ++ + + F L +A
Sbjct: 99 SLSL---LNPGKIL-----EEEMTRYAYYYSGLGAGVLVAAYIQVSFWTL-------AAG 143
Query: 136 RQITRIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSV 195
RQI +IR F ++LRQ++ W+D + L +++++++ I EG+G+K+ + V T
Sbjct: 144 RQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFF 203
Query: 196 ICLCTAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSV 255
F GW+LTL A+ P +++ + + S +E+ +Y+ AG AEE L ++
Sbjct: 204 AGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAI 263
Query: 256 RTIVAFGGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLV 315
RT++AFGG+NKE+ERY++ LE A+E G K+ + + G ++L Y+ A+ F YG+ LV
Sbjct: 264 RTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLV 323
Query: 316 VNDFDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREP 375
++ ++Y +G ++ FS+ + S P ++ F IF +I+ P
Sbjct: 324 IS--------KEYTIGNAMTVFFSILIGAFSAGQAAPCIDAFANARGAAYVIFDIIDNNP 375
Query: 376 KIDSLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGK 435
KIDS ++G P + G++ DV F YPSR VK+LKG ++ V+ G+ VALVGSSGCGK
Sbjct: 376 KIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGK 435
Query: 436 STVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSP 495
ST +QL+QRLYDP G++ ++LR +GVV QEPVLF TI +NI G
Sbjct: 436 STTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRG 495
Query: 496 EATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLL 555
T +EI++ + A A++FI LP +DT++GERGA LSGGQKQRIAIAR+L+R P +LL
Sbjct: 496 NVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILL 555
Query: 556 LDEATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHE 615
LDEATSALD SE +VQAALD+A GRTTI ++HRLST+ NAD I + GVIVEQG+H
Sbjct: 556 LDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHS 615
Query: 616 DLMKAKGFYHKLV 628
+LMK +G Y KLV
Sbjct: 616 ELMKKEGVYFKLV 628
Score = 336 bits (825), Expect = 4e-91
Identities = 196/510 (38%), Positives = 291/510 (57%), Gaps = 25/510 (4%)
Query: 140 RIRTLFLRSVLRQDMSWYDT--DSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVIC 197
R+R++ +++LRQDMSW+D +S L+++++ + ++ G +LA+++ +
Sbjct: 786 RLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTG 845
Query: 198 LCTAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRT 257
+ +F GWQLTL AV+P ++ I ++ R+ + AGK A E ++++RT
Sbjct: 846 IIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRT 905
Query: 258 IVAFGGENKEVERY-RRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVV 316
+V+ E K Y +L P +K ++ G+ + Y A F +G L+V
Sbjct: 906 VVSLTQERKFESMYVEKLYGPYRNSVQKAHIY-GITFSISQAFMYFSYAGCFRFGAYLIV 964
Query: 317 NDFDTDSNLRQYPVGAVYS-ILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREP 375
N ++R V V+S I+F + +F + +F L ER+P
Sbjct: 965 N-----GHMRFRDVILVFSAIVFGAVALGHASSFA----PDYAKAKLSAAHLFMLFERQP 1015
Query: 376 KIDSLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGK 435
IDS ++GL P + G+I +V F YP+R V VL+G S+ VK G+ +ALVGSSGCGK
Sbjct: 1016 LIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGK 1075
Query: 436 STVLQLLQRLYDPQAGSVXXXXXX-------XXXXXXSWLRSSLGVVGQEPVLFRGTIYD 488
STV+QLL+R YDP AG+V WLR+ LG+V QEP+LF +I +
Sbjct: 1076 STVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAE 1135
Query: 489 NIAIG--SPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARS 546
NIA G S +++EI A+ A H FI LP+ Y+T +G++G LSGGQKQRIAIAR+
Sbjct: 1136 NIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARA 1195
Query: 547 LLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQG 606
L+R+P +LLLDEATSALD SE+ VQ ALD+A GRT I ++HRLSTI NAD I+ G
Sbjct: 1196 LIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNG 1255
Query: 607 VIVEQGTHEDLMKAKGFYHKLVT--TGNEN 634
+ E GTH+ L+ KG Y +V+ G +N
Sbjct: 1256 RVKEHGTHQQLLAQKGIYFSMVSVQAGTQN 1285
Score = 332 bits (817), Expect = 3e-90
Identities = 189/484 (39%), Positives = 287/484 (59%), Gaps = 19/484 (3%)
Query: 721 VKTVSDWQLLKLNAPEWPLITVGSIAAFLQGACFPVFALLFGFSSGIFILDNRDDII--Y 778
V VS ++LKLN EWP VG++ A G P F+++F S I I DD +
Sbjct: 692 VPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIF--SEIIAIFGPGDDAVKQQ 749
Query: 779 LADLYSVLFVVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNT 838
+++S++F+ + ++ + LQ TF AG +T RLR F ++L+Q++ +FD N+
Sbjct: 750 KCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNS 809
Query: 839 VGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLM-V 897
GA+ RL+ D A+VQGATG R+ LI Q I+++ G +++ Y W+LTL+ +P++ V
Sbjct: 810 TGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAV 869
Query: 898 GSIWLEGIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACV 957
I +++ A+ D++ +E+A IATEA+ +I+TV SL E F + + L
Sbjct: 870 SGIVEMKLLAGNAKRDKKE-LEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYR 928
Query: 958 AVAYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLG 1017
K G+ + + + +Y +GA L+ G M ++ V+LV AI++GA LG
Sbjct: 929 NSVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALG 988
Query: 1018 QSLVYAPSLNTAKACGARILSIIQRQPKI--HNAVGVKDKKDWVASGNFSMRDVEFCYPT 1075
+ +AP AK A + + +RQP I ++ G+K K GN + +V F YPT
Sbjct: 989 HASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDK---FEGNITFNEVVFNYPT 1045
Query: 1076 RPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDP-------DSGFIELDNR 1128
R + VL+G+ L+++ G+T+ALVGSSGCGKST++QL +RFYDP D GF LD +
Sbjct: 1046 RANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQ 1105
Query: 1129 DIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFI 1188
+ + L + LR QLG+V QEP+L D S+AENIAYGDN+R V+ EIV+AAKAANIH FI
Sbjct: 1106 EAKK-LNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFI 1164
Query: 1189 VSLP 1192
+LP
Sbjct: 1165 ETLP 1168
Score = 242 bits (593), Expect = 5e-63
Identities = 143/413 (34%), Positives = 227/413 (54%), Gaps = 10/413 (2%)
Query: 783 YSVLFVVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAI 842
Y+ + + A ++ +Q + +T A + ++R ++F ++L+QEIG+FD N +
Sbjct: 116 YAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFD--INDTTEL 173
Query: 843 CARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLM--VGSI 900
RL+ D +++ G ++G+ Q +++ GF++ WKLTLV P++ ++
Sbjct: 174 NTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAV 233
Query: 901 WLEGIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVA 960
W + I+S + E A A A+A EA+ +I+TV + G + L+++Q L+ A
Sbjct: 234 WAK-ILSAFSD-KELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGI 291
Query: 961 YKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSL 1020
K + G+ + + +Y A YG+ LV E + V +I+ GA+ GQ+
Sbjct: 292 KKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSAGQAA 351
Query: 1021 VYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQR 1080
+ A+ I II PKI + K D + GN DV F YP+R + +
Sbjct: 352 PCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSI-KGNLEFNDVHFSYPSRANVK 410
Query: 1081 VLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLR 1140
+LKG++LK+++G+T+ALVGSSGCGKST +QL QR YDPD G I +D +DIR+ + LR
Sbjct: 411 ILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRN-FNVNYLR 469
Query: 1141 RQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPK 1193
+GVV QEPVL ++AENI YG N VTM EI A K AN + FI+ LP+
Sbjct: 470 EIIGVVSQEPVLFSTTIAENICYGRGN--VTMDEIKKAVKEANAYEFIMKLPQ 520
Score = 77.0 bits (181), Expect = 4e-13
Identities = 34/59 (57%), Positives = 45/59 (76%)
Query: 1193 KAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRM 1251
K V EAL+KA +GRTCI IAHRLST+++ADLI V G++ E GTH +L++ KG Y+ M
Sbjct: 1218 KVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSM 1276
Score = 66.1 bits (154), Expect = 8e-10
Identities = 31/61 (50%), Positives = 45/61 (73%)
Query: 1195 VTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRMCRG 1254
V AL+KA +GRT I IAHRLSTV++AD+I + G IVE+G+H+EL+ +G Y+++
Sbjct: 571 VQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNM 630
Query: 1255 Q 1255
Q
Sbjct: 631 Q 631
>AF136523-1|AAD28285.1| 1321|Homo sapiens bile salt export pump
protein.
Length = 1321
Score = 408 bits (1005), Expect = e-113
Identities = 232/642 (36%), Positives = 354/642 (55%), Gaps = 19/642 (2%)
Query: 18 VSFFQIFRYGNCLELLATALGVVFGMISGAGVCCNLLQIGELSTAFVERTKYHDRLSSYL 77
V FFQ+FR+ + ++ +G + + G LL G ++ F++ L +
Sbjct: 45 VGFFQLFRFSSSTDIWLMFVGSLCAFLHGIAQPGVLLIFGTMTDVFIDYDVELQELQ--I 102
Query: 78 PLTATFGGGKRLVNATHEQNME-----ALIDDAKAMAIGMFISIGVSLVFCVLSFSLIS- 131
P A N++ QNM L++ M G+++ + + I
Sbjct: 103 PGKACVNNTIVWTNSSLNQNMTNGTRCGLLNIESEMIKFASYYAGIAVAVLITGYIQICF 162
Query: 132 W--SALRQITRIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSN 189
W +A RQI ++R + R ++R ++ W+D +S L ++ S+++ I + + +++A+
Sbjct: 163 WVIAAARQIQKMRKFYFRRIMRMEIGWFDCNSVGELNTRFSDDINKINDAIADQMALFIQ 222
Query: 190 LVGTSVIC-LCTAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQA 248
+ TS IC F GW+LTL +V P I + + +K + E+++Y+ AG A
Sbjct: 223 RM-TSTICGFLLGFFRGWKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKAGVVA 281
Query: 249 EEILKSVRTIVAFGGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGF 308
+E++ S+RT+ AFGGE +EVERY + L A+ +G ++G+ G GF W L + A+ F
Sbjct: 282 DEVISSMRTVAAFGGEKREVERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYALAF 341
Query: 309 SYGTRLVVNDFDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIF 368
YG+ LV+++ +Y G + I SV + ++ P LE F SIF
Sbjct: 342 WYGSTLVLDE-------GEYTPGTLVQIFLSVIVGALNLGNASPCLEAFATGRAAATSIF 394
Query: 369 HLIEREPKIDSLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALV 428
I+R+P ID + + G R+ G+I +V F YPSRPEVK+L ++ +KPGE ALV
Sbjct: 395 ETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMAIKPGEMTALV 454
Query: 429 GSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYD 488
G SG GKST LQL+QR YDP G V WLR +G+V QEPVLF TI +
Sbjct: 455 GPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAE 514
Query: 489 NIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLL 548
NI G +AT E+I + A+ A A++FI LP +DT++GE G +SGGQKQR+AIAR+L+
Sbjct: 515 NIRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALI 574
Query: 549 REPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVI 608
R P +LLLD ATSALD SE VQ L + G T I+V+HRLST+ AD II + G
Sbjct: 575 RNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTA 634
Query: 609 VEQGTHEDLMKAKGFYHKLVTTGNENKEPADIEPLIEEADGD 650
VE+GTHE+L++ KG Y LVT ++ + + E + + + D
Sbjct: 635 VERGTHEELLERKGVYFTLVTLQSQGNQALNEEDIKDATEDD 676
Score = 332 bits (817), Expect = 3e-90
Identities = 183/526 (34%), Positives = 284/526 (53%), Gaps = 13/526 (2%)
Query: 112 MFISIG-VSLVFCVLSFSLISWSALRQITRIRTLFLRSVLRQDMSWYDT--DSEFNLASK 168
+F+++G VSL L + S R+R R++L QD++W+D +S L ++
Sbjct: 801 LFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGALTTR 860
Query: 169 MSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPLGWQLTLACAAVMPFSVITSIALSN 228
++ + ++ G ++ ++ N + + AF W+L+L PF ++ +
Sbjct: 861 LATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLALSGATQTR 920
Query: 229 YQTKSSIREMESYSLAGKQAEEILKSVRTIVAFGGENKEVERYRRLLEPAEEFGRKRGLF 288
T + R+ ++ + G+ E L ++RT+ G E + +E LE + ++
Sbjct: 921 MLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETELEKPFKTAIQKANI 980
Query: 289 TGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVYSILFSVYMATQSIT 348
G F + + N+ + YG L+ N+ V+ ++ +V ++ ++
Sbjct: 981 YGFCFAFAQCIMFIANSASYRYGGYLISNE--------GLHFSYVFRVISAVVLSATALG 1032
Query: 349 FCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPRRVVGDILLEDVEFCYPSRPE 408
+ + F L++R+P I G G I D +F YPSRP+
Sbjct: 1033 RAFSYTPSYAKAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPD 1092
Query: 409 VKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWL 468
+VL G S+ + PG+ +A VGSSGCGKST +QLL+R YDP G V +L
Sbjct: 1093 SQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFL 1152
Query: 469 RSSLGVVGQEPVLFRGTIYDNIAIG--SPEATREEIQRVAEIAYAHDFISLLPNGYDTVI 526
RS++G+V QEPVLF +I DNI G + E E + A+ A HDF+ LP Y+T +
Sbjct: 1153 RSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNV 1212
Query: 527 GERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTIT 586
G +G+ LS G+KQRIAIAR+++R+P +LLLDEATSALD SE+ VQ ALD+A GRT I
Sbjct: 1213 GSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIV 1272
Query: 587 VSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGN 632
++HRLSTI NAD I M QGV++E+GTHE+LM KG Y+KLVTTG+
Sbjct: 1273 IAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLVTTGS 1318
Score = 309 bits (758), Expect = 5e-83
Identities = 163/468 (34%), Positives = 261/468 (55%), Gaps = 6/468 (1%)
Query: 728 QLLKLNAPEWPLITVGSIAAFLQGACFPVFALLFGFSSGIFILDNRDDIIYLADLYSVLF 787
++LK +APEWP + VGS+ A + G P++A LF G F + ++++ + +LF
Sbjct: 743 RILKFSAPEWPYMLVGSVGAAVNGTVTPLYAFLFSQILGTFSIPDKEEQRSQINGVCLLF 802
Query: 788 VVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICARLS 847
V + V+ + LQ F +G +T RLR F ++L Q+I +FD N+ GA+ RL+
Sbjct: 803 VAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGALTTRLA 862
Query: 848 GDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLMVGSIWLEGIIS 907
D ++VQGA G +IG+I+ ++V V ++A S++WKL+LV F P + S + +
Sbjct: 863 TDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLALSGATQTRML 922
Query: 908 QKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVAYKTRWRG 967
++ A+E I EA+ +I+TV +G E F++ + L+ K G
Sbjct: 923 TGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETELEKPFKTAIQKANIYG 982
Query: 968 LVYGLGVYIPFMAYCSATVYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYAPSLN 1027
+ I F+A ++ YG L++ + + V V A++ A LG++ Y PS
Sbjct: 983 FCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRAFSYTPSYA 1042
Query: 1028 TAKACGARILSIIQRQP--KIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGI 1085
AK AR ++ RQP ++N G +K D G D +F YP+RP +VL G+
Sbjct: 1043 KAKISAARFFQLLDRQPPISVYNTAG--EKWD-NFQGKIDFVDCKFTYPSRPDSQVLNGL 1099
Query: 1086 DLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGV 1145
+ + G+T+A VGSSGCGKST +QL +RFYDPD G + +D D + + + LR +G+
Sbjct: 1100 SVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKK-VNVQFLRSNIGI 1158
Query: 1146 VQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPK 1193
V QEPVL S+ +NI YGDN +++ M ++AAAK A +H F++SLP+
Sbjct: 1159 VSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPE 1206
Score = 217 bits (529), Expect = 3e-55
Identities = 143/427 (33%), Positives = 220/427 (51%), Gaps = 13/427 (3%)
Query: 769 ILDNRDDIIYLADLYSVLFVVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQE 828
+L+ ++I A Y+ + V + I +C + A + ++R YF +++ E
Sbjct: 131 LLNIESEMIKFASYYAGIAVAVLITGYIQICF----WVIAAARQIQKMRKFYFRRIMRME 186
Query: 829 IGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLV 888
IG+FD N+VG + R S D ++ A ++ L +Q ++S + GFLL WKLTLV
Sbjct: 187 IGWFD--CNSVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWKLTLV 244
Query: 889 ATVFLPLM-VGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQK 947
PL+ +G+ + G+ K E A A +A E + S++TV + G E +++
Sbjct: 245 IISVSPLIGIGAATI-GLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKREVER 303
Query: 948 FQDALKTACVAVAYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVA-YGEMEYKLVLLVN 1006
++ L A K G G + F+ Y A YG+ LV GE ++ +
Sbjct: 304 YEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYALAFWYGSTLVLDEGEYTPGTLVQIF 363
Query: 1007 EAIMYGAYMLGQSLVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSM 1066
+++ GA LG + + T +A I I R+P I K D + G
Sbjct: 364 LSVIVGALNLGNASPCLEAFATGRAAATSIFETIDRKPIIDCMSEDGYKLDRI-KGEIEF 422
Query: 1067 RDVEFCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELD 1126
+V F YP+RP ++L +++ ++ G+ ALVG SG GKST LQL QRFYDP G + +D
Sbjct: 423 HNVTFHYPSRPEVKILNDLNMAIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVD 482
Query: 1127 NRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHS 1186
DIRS L I LR Q+G+V+QEPVL ++AENI YG TM +IV AAK AN ++
Sbjct: 483 GHDIRS-LNIQWLRDQIGIVEQEPVLFSTTIAENIRYG--REDATMEDIVQAAKEANAYN 539
Query: 1187 FIVSLPK 1193
FI+ LP+
Sbjct: 540 FIMDLPQ 546
Score = 77.0 bits (181), Expect = 4e-13
Identities = 32/59 (54%), Positives = 48/59 (81%)
Query: 1193 KAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRM 1251
K V AL+KA +GRTCI IAHRLST+++AD+I V+ +G ++E+GTH EL++ KG Y+++
Sbjct: 1255 KTVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKL 1313
Score = 59.7 bits (138), Expect = 7e-08
Identities = 29/57 (50%), Positives = 36/57 (63%)
Query: 1195 VTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRM 1251
V E L K G T I++AHRLSTV+ AD I + G VERGTH EL+ KG Y+ +
Sbjct: 597 VQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTL 653
>AF091582-1|AAC77455.1| 1321|Homo sapiens bile salt export pump
protein.
Length = 1321
Score = 408 bits (1005), Expect = e-113
Identities = 232/642 (36%), Positives = 354/642 (55%), Gaps = 19/642 (2%)
Query: 18 VSFFQIFRYGNCLELLATALGVVFGMISGAGVCCNLLQIGELSTAFVERTKYHDRLSSYL 77
V FFQ+FR+ + ++ +G + + G LL G ++ F++ L +
Sbjct: 45 VGFFQLFRFSSSTDIWLMFVGSLCAFLHGIAQPGVLLIFGTMTDVFIDYDVELQELQ--I 102
Query: 78 PLTATFGGGKRLVNATHEQNME-----ALIDDAKAMAIGMFISIGVSLVFCVLSFSLIS- 131
P A N++ QNM L++ M G+++ + + I
Sbjct: 103 PGKACVNNTIVWTNSSLNQNMTNGTRCGLLNIESEMIKFASYYAGIAVAVLITGYIQICF 162
Query: 132 W--SALRQITRIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSN 189
W +A RQI ++R + R ++R ++ W+D +S L ++ S+++ I + + +++A+
Sbjct: 163 WVIAAARQIQKMRKFYFRRIMRMEIGWFDCNSVGELNTRFSDDINKINDAIADQMALFIQ 222
Query: 190 LVGTSVIC-LCTAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQA 248
+ TS IC F GW+LTL +V P I + + +K + E+++Y+ AG A
Sbjct: 223 RM-TSTICGFLLGFFRGWKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKAGVVA 281
Query: 249 EEILKSVRTIVAFGGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGF 308
+E++ S+RT+ AFGGE +EVERY + L A+ +G ++G+ G GF W L + A+ F
Sbjct: 282 DEVISSMRTVAAFGGEKREVERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYAVAF 341
Query: 309 SYGTRLVVNDFDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIF 368
YG+ LV+++ +Y G + I SV + ++ P LE F SIF
Sbjct: 342 WYGSTLVLDE-------GEYTPGTLVQIFLSVIVGALNLGNASPCLEAFATGRAAATSIF 394
Query: 369 HLIEREPKIDSLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALV 428
I+R+P ID + + G R+ G+I +V F YPSRPEVK+L ++ +KPGE ALV
Sbjct: 395 ETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALV 454
Query: 429 GSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYD 488
G SG GKST LQL+QR YDP G V WLR +G+V QEPVLF TI +
Sbjct: 455 GPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAE 514
Query: 489 NIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLL 548
NI G +AT E+I + A+ A A++FI LP +DT++GE G +SGGQKQR+AIAR+L+
Sbjct: 515 NIRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALI 574
Query: 549 REPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVI 608
R P +LLLD ATSALD SE VQ L + G T I+V+HRLST+ AD II + G
Sbjct: 575 RNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTA 634
Query: 609 VEQGTHEDLMKAKGFYHKLVTTGNENKEPADIEPLIEEADGD 650
VE+GTHE+L++ KG Y LVT ++ + + E + + + D
Sbjct: 635 VERGTHEELLERKGVYFTLVTLQSQGNQALNEEDIKDATEDD 676
Score = 332 bits (817), Expect = 3e-90
Identities = 183/526 (34%), Positives = 284/526 (53%), Gaps = 13/526 (2%)
Query: 112 MFISIG-VSLVFCVLSFSLISWSALRQITRIRTLFLRSVLRQDMSWYDT--DSEFNLASK 168
+F+++G VSL L + S R+R R++L QD++W+D +S L ++
Sbjct: 801 LFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGALTTR 860
Query: 169 MSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPLGWQLTLACAAVMPFSVITSIALSN 228
++ + ++ G ++ ++ N + + AF W+L+L PF ++ +
Sbjct: 861 LATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLALSGATQTR 920
Query: 229 YQTKSSIREMESYSLAGKQAEEILKSVRTIVAFGGENKEVERYRRLLEPAEEFGRKRGLF 288
T + R+ ++ + G+ E L ++RT+ G E + +E LE + ++
Sbjct: 921 MLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETELEKPFKTAIQKANI 980
Query: 289 TGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVYSILFSVYMATQSIT 348
G F + + N+ + YG L+ N+ V+ ++ +V ++ ++
Sbjct: 981 YGFCFAFAQCIMFIANSASYRYGGYLISNE--------GLHFSYVFRVISAVVLSATALG 1032
Query: 349 FCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPRRVVGDILLEDVEFCYPSRPE 408
+ + F L++R+P I G G I D +F YPSRP+
Sbjct: 1033 RAFSYTPSYAKAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPD 1092
Query: 409 VKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWL 468
+VL G S+ + PG+ +A VGSSGCGKST +QLL+R YDP G V +L
Sbjct: 1093 SQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFL 1152
Query: 469 RSSLGVVGQEPVLFRGTIYDNIAIG--SPEATREEIQRVAEIAYAHDFISLLPNGYDTVI 526
RS++G+V QEPVLF +I DNI G + E E + A+ A HDF+ LP Y+T +
Sbjct: 1153 RSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNV 1212
Query: 527 GERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTIT 586
G +G+ LS G+KQRIAIAR+++R+P +LLLDEATSALD SE+ VQ ALD+A GRT I
Sbjct: 1213 GSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIV 1272
Query: 587 VSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGN 632
++HRLSTI NAD I M QGV++E+GTHE+LM KG Y+KLVTTG+
Sbjct: 1273 IAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLVTTGS 1318
Score = 309 bits (758), Expect = 5e-83
Identities = 163/468 (34%), Positives = 261/468 (55%), Gaps = 6/468 (1%)
Query: 728 QLLKLNAPEWPLITVGSIAAFLQGACFPVFALLFGFSSGIFILDNRDDIIYLADLYSVLF 787
++LK +APEWP + VGS+ A + G P++A LF G F + ++++ + +LF
Sbjct: 743 RILKFSAPEWPYMLVGSVGAAVNGTVTPLYAFLFSQILGTFSIPDKEEQRSQINGVCLLF 802
Query: 788 VVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICARLS 847
V + V+ + LQ F +G +T RLR F ++L Q+I +FD N+ GA+ RL+
Sbjct: 803 VAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGALTTRLA 862
Query: 848 GDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLMVGSIWLEGIIS 907
D ++VQGA G +IG+I+ ++V V ++A S++WKL+LV F P + S + +
Sbjct: 863 TDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLALSGATQTRML 922
Query: 908 QKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVAYKTRWRG 967
++ A+E I EA+ +I+TV +G E F++ + L+ K G
Sbjct: 923 TGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETELEKPFKTAIQKANIYG 982
Query: 968 LVYGLGVYIPFMAYCSATVYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYAPSLN 1027
+ I F+A ++ YG L++ + + V V A++ A LG++ Y PS
Sbjct: 983 FCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRAFSYTPSYA 1042
Query: 1028 TAKACGARILSIIQRQP--KIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGI 1085
AK AR ++ RQP ++N G +K D G D +F YP+RP +VL G+
Sbjct: 1043 KAKISAARFFQLLDRQPPISVYNTAG--EKWD-NFQGKIDFVDCKFTYPSRPDSQVLNGL 1099
Query: 1086 DLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGV 1145
+ + G+T+A VGSSGCGKST +QL +RFYDPD G + +D D + + + LR +G+
Sbjct: 1100 SVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKK-VNVQFLRSNIGI 1158
Query: 1146 VQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPK 1193
V QEPVL S+ +NI YGDN +++ M ++AAAK A +H F++SLP+
Sbjct: 1159 VSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPE 1206
Score = 216 bits (528), Expect = 4e-55
Identities = 143/427 (33%), Positives = 220/427 (51%), Gaps = 13/427 (3%)
Query: 769 ILDNRDDIIYLADLYSVLFVVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQE 828
+L+ ++I A Y+ + V + I +C + A + ++R YF +++ E
Sbjct: 131 LLNIESEMIKFASYYAGIAVAVLITGYIQICF----WVIAAARQIQKMRKFYFRRIMRME 186
Query: 829 IGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLV 888
IG+FD N+VG + R S D ++ A ++ L +Q ++S + GFLL WKLTLV
Sbjct: 187 IGWFD--CNSVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWKLTLV 244
Query: 889 ATVFLPLM-VGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQK 947
PL+ +G+ + G+ K E A A +A E + S++TV + G E +++
Sbjct: 245 IISVSPLIGIGAATI-GLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKREVER 303
Query: 948 FQDALKTACVAVAYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVA-YGEMEYKLVLLVN 1006
++ L A K G G + F+ Y A YG+ LV GE ++ +
Sbjct: 304 YEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYAVAFWYGSTLVLDEGEYTPGTLVQIF 363
Query: 1007 EAIMYGAYMLGQSLVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSM 1066
+++ GA LG + + T +A I I R+P I K D + G
Sbjct: 364 LSVIVGALNLGNASPCLEAFATGRAAATSIFETIDRKPIIDCMSEDGYKLDRI-KGEIEF 422
Query: 1067 RDVEFCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELD 1126
+V F YP+RP ++L +++ ++ G+ ALVG SG GKST LQL QRFYDP G + +D
Sbjct: 423 HNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVD 482
Query: 1127 NRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHS 1186
DIRS L I LR Q+G+V+QEPVL ++AENI YG TM +IV AAK AN ++
Sbjct: 483 GHDIRS-LNIQWLRDQIGIVEQEPVLFSTTIAENIRYG--REDATMEDIVQAAKEANAYN 539
Query: 1187 FIVSLPK 1193
FI+ LP+
Sbjct: 540 FIMDLPQ 546
Score = 77.0 bits (181), Expect = 4e-13
Identities = 32/59 (54%), Positives = 48/59 (81%)
Query: 1193 KAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRM 1251
K V AL+KA +GRTCI IAHRLST+++AD+I V+ +G ++E+GTH EL++ KG Y+++
Sbjct: 1255 KTVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKL 1313
Score = 59.7 bits (138), Expect = 7e-08
Identities = 29/57 (50%), Positives = 36/57 (63%)
Query: 1195 VTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRM 1251
V E L K G T I++AHRLSTV+ AD I + G VERGTH EL+ KG Y+ +
Sbjct: 597 VQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTL 653
>AC008177-1|AAY24305.1| 870|Homo sapiens unknown protein.
Length = 870
Score = 408 bits (1004), Expect = e-113
Identities = 232/642 (36%), Positives = 354/642 (55%), Gaps = 19/642 (2%)
Query: 18 VSFFQIFRYGNCLELLATALGVVFGMISGAGVCCNLLQIGELSTAFVERTKYHDRLSSYL 77
V FFQ+FR+ + ++ +G + + G LL G ++ F++ L +
Sbjct: 45 VGFFQLFRFSSSTDIWLMFVGSLCAFLHGIAQPGVLLIFGTMTDVFIDYDVELQELQ--I 102
Query: 78 PLTATFGGGKRLVNATHEQNME-----ALIDDAKAMAIGMFISIGVSLVFCVLSFSLIS- 131
P A N++ QNM L++ M G+++ + + I
Sbjct: 103 PGKACVNNTIVWTNSSLNQNMTNGTRCGLLNIESEMIKFASYYAGIAVAVLITGYIQICF 162
Query: 132 W--SALRQITRIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSN 189
W +A RQI ++R + R ++R ++ W+D +S L ++ S+++ I + + +++A+
Sbjct: 163 WVIAAARQIQKMRKFYFRRIMRMEIGWFDCNSVGELNTRFSDDINKINDAIADQMALFIQ 222
Query: 190 LVGTSVIC-LCTAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQA 248
+ TS IC F GW+LTL +V P I + + +K + E+++Y+ AG A
Sbjct: 223 RM-TSTICGFLLGFFRGWKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKAGVVA 281
Query: 249 EEILKSVRTIVAFGGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGF 308
+E++ S+RT+ AFGGE +EVERY + L A+ +G ++G+ G GF W L + A+ F
Sbjct: 282 DEVISSMRTVAAFGGEKREVERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYALAF 341
Query: 309 SYGTRLVVNDFDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIF 368
YG+ LV+++ +Y G + I SV + ++ P LE F SIF
Sbjct: 342 WYGSTLVLDE-------GEYTPGTLVQIFLSVIVGALNLGNASPCLEAFATGRAAATSIF 394
Query: 369 HLIEREPKIDSLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALV 428
I+R+P ID + + G R+ G+I +V F YPSRPEVK+L ++ +KPGE ALV
Sbjct: 395 ETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALV 454
Query: 429 GSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYD 488
G SG GKST LQL+QR YDP G V WLR +G+V QEPVLF TI +
Sbjct: 455 GPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAE 514
Query: 489 NIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLL 548
NI G +AT E+I + A+ A A++FI LP +DT++GE G +SGGQKQR+AIAR+L+
Sbjct: 515 NIRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALI 574
Query: 549 REPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVI 608
R P +LLLD ATSALD SE VQ L + G T I+V+HRLST+ AD II + G
Sbjct: 575 RNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTA 634
Query: 609 VEQGTHEDLMKAKGFYHKLVTTGNENKEPADIEPLIEEADGD 650
VE+GTHE+L++ KG Y LVT ++ + + E + + + D
Sbjct: 635 VERGTHEELLERKGVYFTLVTLQSQGNQALNEEDIKDATEDD 676
Score = 216 bits (528), Expect = 4e-55
Identities = 143/427 (33%), Positives = 220/427 (51%), Gaps = 13/427 (3%)
Query: 769 ILDNRDDIIYLADLYSVLFVVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQE 828
+L+ ++I A Y+ + V + I +C + A + ++R YF +++ E
Sbjct: 131 LLNIESEMIKFASYYAGIAVAVLITGYIQICF----WVIAAARQIQKMRKFYFRRIMRME 186
Query: 829 IGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLV 888
IG+FD N+VG + R S D ++ A ++ L +Q ++S + GFLL WKLTLV
Sbjct: 187 IGWFD--CNSVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWKLTLV 244
Query: 889 ATVFLPLM-VGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQK 947
PL+ +G+ + G+ K E A A +A E + S++TV + G E +++
Sbjct: 245 IISVSPLIGIGAATI-GLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKREVER 303
Query: 948 FQDALKTACVAVAYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVA-YGEMEYKLVLLVN 1006
++ L A K G G + F+ Y A YG+ LV GE ++ +
Sbjct: 304 YEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYALAFWYGSTLVLDEGEYTPGTLVQIF 363
Query: 1007 EAIMYGAYMLGQSLVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSM 1066
+++ GA LG + + T +A I I R+P I K D + G
Sbjct: 364 LSVIVGALNLGNASPCLEAFATGRAAATSIFETIDRKPIIDCMSEDGYKLDRI-KGEIEF 422
Query: 1067 RDVEFCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELD 1126
+V F YP+RP ++L +++ ++ G+ ALVG SG GKST LQL QRFYDP G + +D
Sbjct: 423 HNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVD 482
Query: 1127 NRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHS 1186
DIRS L I LR Q+G+V+QEPVL ++AENI YG TM +IV AAK AN ++
Sbjct: 483 GHDIRS-LNIQWLRDQIGIVEQEPVLFSTTIAENIRYG--REDATMEDIVQAAKEANAYN 539
Query: 1187 FIVSLPK 1193
FI+ LP+
Sbjct: 540 FIMDLPQ 546
Score = 88.2 bits (209), Expect = 2e-16
Identities = 45/128 (35%), Positives = 74/128 (57%)
Query: 728 QLLKLNAPEWPLITVGSIAAFLQGACFPVFALLFGFSSGIFILDNRDDIIYLADLYSVLF 787
++LK +APEWP + VGS+ A + G P++A LF G F + ++++ + +LF
Sbjct: 743 RILKFSAPEWPYMLVGSVGAAVNGTVTPLYAFLFSQILGTFSIPDKEEQRSQINGVCLLF 802
Query: 788 VVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICARLS 847
V + V+ + LQ F +G +T RLR F ++L Q+I +FD N+ GA+ RL+
Sbjct: 803 VAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGALTTRLA 862
Query: 848 GDTAEVQG 855
D ++VQG
Sbjct: 863 TDASQVQG 870
Score = 59.7 bits (138), Expect = 7e-08
Identities = 29/57 (50%), Positives = 36/57 (63%)
Query: 1195 VTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRM 1251
V E L K G T I++AHRLSTV+ AD I + G VERGTH EL+ KG Y+ +
Sbjct: 597 VQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTL 653
>BC104920-1|AAI04921.1| 812|Homo sapiens ATP-binding cassette,
sub-family B (MDR/TAP), member 5 protein.
Length = 812
Score = 335 bits (824), Expect = 5e-91
Identities = 174/470 (37%), Positives = 281/470 (59%), Gaps = 2/470 (0%)
Query: 724 VSDWQLLKLNAPEWPLITVGSIAAFLQGACFPVFALLFGFSSGIFILDNRDDIIYLADLY 783
VS ++LKLN PEWP + +G++A+ L G PVF+++F +F +++ + + A++Y
Sbjct: 231 VSLLKILKLNKPEWPFVVLGTLASVLNGTVHPVFSIIFAKIITMFGNNDKTTLKHDAEIY 290
Query: 784 SVLFVVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAIC 843
S++FV++ + +S +Q + AG +T RLRH F ++L Q+I +FD++ N+ G +
Sbjct: 291 SMIFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGGLT 350
Query: 844 ARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLMVGSIWLE 903
L+ D A++QGATG RIG++ Q +++ + +++ Y W++T + P++ + +E
Sbjct: 351 TILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGMIE 410
Query: 904 GIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVAYKT 963
++ ++ A IATEA+ +I+T+ SL E F Q +++ L+T + K
Sbjct: 411 TAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTSKKA 470
Query: 964 RWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYA 1023
+ G Y + AY + +GA L+ G M + + +V AI YGA +G++LV A
Sbjct: 471 QIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIVFTAIAYGAMAIGETLVLA 530
Query: 1024 PSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLK 1083
P + AK+ A + ++++++P I ++ + KK GN R+V F YP RP +L+
Sbjct: 531 PEYSKAKSGAAHLFALLEKKPNI-DSRSQEGKKPDTCEGNLEFREVSFFYPCRPDVFILR 589
Query: 1084 GIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQL 1143
G+ L +E GKT+A VGSSGCGKST +QL QR YDP G + D D + L + LR Q+
Sbjct: 590 GLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKE-LNVQWLRSQI 648
Query: 1144 GVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPK 1193
+V QEPVL + S+AENIAYGDN+R V + EI AA AANIHSFI LP+
Sbjct: 649 AIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPE 698
Score = 324 bits (795), Expect = 2e-87
Identities = 190/546 (34%), Positives = 293/546 (53%), Gaps = 14/546 (2%)
Query: 88 RLVNATHEQNMEALIDDAKAMAIGMFISIGVSLVFCVLSFSLISWSALRQIT-RIRTLFL 146
+++ + L DA+ ++ +F+ +GV L A +T R+R L
Sbjct: 270 KIITMFGNNDKTTLKHDAEIYSM-IFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAF 328
Query: 147 RSVLRQDMSWYDT--DSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPL 204
+++L QD++W+D +S L + ++ ++ I+ G ++ V++ + + +F
Sbjct: 329 KAMLYQDIAWFDEKENSTGGLTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIY 388
Query: 205 GWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAFGGE 264
GW++T ++ P +T + + T + ++ + AGK A E L+++RTIV+ E
Sbjct: 389 GWEMTFLILSIAPVLAVTGMIETAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTRE 448
Query: 265 NKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSN 324
+ Y +L+ K+ G F+ Y A GF +G L+
Sbjct: 449 KAFEQMYEEMLQTQHRNTSKKAQIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAG------ 502
Query: 325 LRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKG 384
R P G ++ + ++ +I + + +F L+E++P IDS Q+G
Sbjct: 503 -RMTPEG-MFIVFTAIAYGAMAIGETLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEG 560
Query: 385 LTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQR 444
P G++ +V F YP RP+V +L+G S+ ++ G+ VA VGSSGCGKST +QLLQR
Sbjct: 561 KKPDTCEGNLEFREVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQR 620
Query: 445 LYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIG--SPEATREEI 502
LYDP G V WLRS + +V QEPVLF +I +NIA G S +EI
Sbjct: 621 LYDPVQGQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEI 680
Query: 503 QRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSA 562
+ A A H FI LP Y+T +G +GA LSGGQKQR+AIAR+LL++P +LLLDEATSA
Sbjct: 681 KEAANAANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSA 740
Query: 563 LDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKG 622
LD SE+ VQ ALD+A GRT + V+HRLS I NAD I+ + G I EQGTH++L++ +
Sbjct: 741 LDNDSEKVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRD 800
Query: 623 FYHKLV 628
Y KLV
Sbjct: 801 IYFKLV 806
Score = 188 bits (458), Expect = 1e-46
Identities = 92/175 (52%), Positives = 125/175 (71%)
Query: 469 RSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGE 528
R +GVV QEPVLF TI +NI G + T EE++R A A A+DFI PN ++T++GE
Sbjct: 16 RDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDFIMEFPNKFNTLVGE 75
Query: 529 RGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVS 588
+GA +SGGQKQRIAIAR+L+R P +L+LDEATSALD S+ VQAAL++AS GRTTI V+
Sbjct: 76 KGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAALEKASKGRTTIVVA 135
Query: 589 HRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENKEPADIEPL 643
HRLSTI +AD I+ + G++ E+G H +LM +G Y+ LV + + K +E +
Sbjct: 136 HRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQDIKKADEQMESM 190
Score = 72.5 bits (170), Expect = 9e-12
Identities = 32/64 (50%), Positives = 46/64 (71%)
Query: 1194 AVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRMCR 1253
AV ALEKA+KGRT I +AHRLST++ ADLI + G + E+G HAEL++ +G Y+ +
Sbjct: 117 AVQAALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVM 176
Query: 1254 GQNM 1257
Q++
Sbjct: 177 SQDI 180
Score = 69.7 bits (163), Expect = 6e-11
Identities = 30/65 (46%), Positives = 45/65 (69%)
Query: 1193 KAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRMC 1252
K V AL+KA GRTC+ + HRLS +++ADLI V+ GKI E+GTH EL+ + Y+++
Sbjct: 747 KVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLV 806
Query: 1253 RGQNM 1257
Q++
Sbjct: 807 NAQSV 811
Score = 53.6 bits (123), Expect = 4e-06
Identities = 34/81 (41%), Positives = 47/81 (58%), Gaps = 4/81 (4%)
Query: 1125 LDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANI 1184
+D DIR AL + R +GVV QEPVL +++ NI YG ++ VT E+ AA+ AN
Sbjct: 2 VDENDIR-ALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDD--VTDEEMERAAREANA 58
Query: 1185 HSFIVSLP-KAVTEALEKAAK 1204
+ FI+ P K T EK A+
Sbjct: 59 YDFIMEFPNKFNTLVGEKGAQ 79
>BC104894-1|AAI04895.2| 812|Homo sapiens ATP-binding cassette,
sub-family B (MDR/TAP), member 5 protein.
Length = 812
Score = 335 bits (824), Expect = 5e-91
Identities = 174/470 (37%), Positives = 281/470 (59%), Gaps = 2/470 (0%)
Query: 724 VSDWQLLKLNAPEWPLITVGSIAAFLQGACFPVFALLFGFSSGIFILDNRDDIIYLADLY 783
VS ++LKLN PEWP + +G++A+ L G PVF+++F +F +++ + + A++Y
Sbjct: 231 VSLLKILKLNKPEWPFVVLGTLASVLNGTVHPVFSIIFAKIITMFGNNDKTTLKHDAEIY 290
Query: 784 SVLFVVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAIC 843
S++FV++ + +S +Q + AG +T RLRH F ++L Q+I +FD++ N+ G +
Sbjct: 291 SMIFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGGLT 350
Query: 844 ARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLMVGSIWLE 903
L+ D A++QGATG RIG++ Q +++ + +++ Y W++T + P++ + +E
Sbjct: 351 TILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGMIE 410
Query: 904 GIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVAYKT 963
++ ++ A IATEA+ +I+T+ SL E F Q +++ L+T + K
Sbjct: 411 TAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTSKKA 470
Query: 964 RWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYA 1023
+ G Y + AY + +GA L+ G M + + +V AI YGA +G++LV A
Sbjct: 471 QIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIVFTAIAYGAMAIGETLVLA 530
Query: 1024 PSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLK 1083
P + AK+ A + ++++++P I ++ + KK GN R+V F YP RP +L+
Sbjct: 531 PEYSKAKSGAAHLFALLEKKPNI-DSRSQEGKKPDTCEGNLEFREVSFFYPCRPDVFILR 589
Query: 1084 GIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQL 1143
G+ L +E GKT+A VGSSGCGKST +QL QR YDP G + D D + L + LR Q+
Sbjct: 590 GLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKE-LNVQWLRSQI 648
Query: 1144 GVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPK 1193
+V QEPVL + S+AENIAYGDN+R V + EI AA AANIHSFI LP+
Sbjct: 649 AIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPE 698
Score = 324 bits (795), Expect = 2e-87
Identities = 190/546 (34%), Positives = 293/546 (53%), Gaps = 14/546 (2%)
Query: 88 RLVNATHEQNMEALIDDAKAMAIGMFISIGVSLVFCVLSFSLISWSALRQIT-RIRTLFL 146
+++ + L DA+ ++ +F+ +GV L A +T R+R L
Sbjct: 270 KIITMFGNNDKTTLKHDAEIYSM-IFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAF 328
Query: 147 RSVLRQDMSWYDT--DSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPL 204
+++L QD++W+D +S L + ++ ++ I+ G ++ V++ + + +F
Sbjct: 329 KAMLYQDIAWFDEKENSTGGLTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIY 388
Query: 205 GWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAFGGE 264
GW++T ++ P +T + + T + ++ + AGK A E L+++RTIV+ E
Sbjct: 389 GWEMTFLILSIAPVLAVTGMIETAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTRE 448
Query: 265 NKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSN 324
+ Y +L+ K+ G F+ Y A GF +G L+
Sbjct: 449 KAFEQMYEEMLQTQHRNTSKKAQIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAG------ 502
Query: 325 LRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKG 384
R P G ++ + ++ +I + + +F L+E++P IDS Q+G
Sbjct: 503 -RMTPEG-MFIVFTAIAYGAMAIGETLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEG 560
Query: 385 LTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQR 444
P G++ +V F YP RP+V +L+G S+ ++ G+ VA VGSSGCGKST +QLLQR
Sbjct: 561 KKPDTCEGNLEFREVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQR 620
Query: 445 LYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIG--SPEATREEI 502
LYDP G V WLRS + +V QEPVLF +I +NIA G S +EI
Sbjct: 621 LYDPVQGQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEI 680
Query: 503 QRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSA 562
+ A A H FI LP Y+T +G +GA LSGGQKQR+AIAR+LL++P +LLLDEATSA
Sbjct: 681 KEAANAANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSA 740
Query: 563 LDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKG 622
LD SE+ VQ ALD+A GRT + V+HRLS I NAD I+ + G I EQGTH++L++ +
Sbjct: 741 LDNDSEKVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRD 800
Query: 623 FYHKLV 628
Y KLV
Sbjct: 801 IYFKLV 806
Score = 188 bits (458), Expect = 1e-46
Identities = 92/175 (52%), Positives = 125/175 (71%)
Query: 469 RSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGE 528
R +GVV QEPVLF TI +NI G + T EE++R A A A+DFI PN ++T++GE
Sbjct: 16 RDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDFIMEFPNKFNTLVGE 75
Query: 529 RGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVS 588
+GA +SGGQKQRIAIAR+L+R P +L+LDEATSALD S+ VQAAL++AS GRTTI V+
Sbjct: 76 KGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAALEKASKGRTTIVVA 135
Query: 589 HRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENKEPADIEPL 643
HRLSTI +AD I+ + G++ E+G H +LM +G Y+ LV + + K +E +
Sbjct: 136 HRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQDIKKADEQMESM 190
Score = 72.5 bits (170), Expect = 9e-12
Identities = 32/64 (50%), Positives = 46/64 (71%)
Query: 1194 AVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRMCR 1253
AV ALEKA+KGRT I +AHRLST++ ADLI + G + E+G HAEL++ +G Y+ +
Sbjct: 117 AVQAALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVM 176
Query: 1254 GQNM 1257
Q++
Sbjct: 177 SQDI 180
Score = 69.7 bits (163), Expect = 6e-11
Identities = 30/65 (46%), Positives = 45/65 (69%)
Query: 1193 KAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRMC 1252
K V AL+KA GRTC+ + HRLS +++ADLI V+ GKI E+GTH EL+ + Y+++
Sbjct: 747 KVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLV 806
Query: 1253 RGQNM 1257
Q++
Sbjct: 807 NAQSV 811
Score = 53.6 bits (123), Expect = 4e-06
Identities = 34/81 (41%), Positives = 47/81 (58%), Gaps = 4/81 (4%)
Query: 1125 LDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANI 1184
+D DIR AL + R +GVV QEPVL +++ NI YG ++ VT E+ AA+ AN
Sbjct: 2 VDENDIR-ALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDD--VTDEEMERAAREANA 58
Query: 1185 HSFIVSLP-KAVTEALEKAAK 1204
+ FI+ P K T EK A+
Sbjct: 59 YDFIMEFPNKFNTLVGEKGAQ 79
>AY234788-1|AAO73470.1| 812|Homo sapiens P-glycoprotein ABCB5
protein.
Length = 812
Score = 335 bits (823), Expect = 7e-91
Identities = 174/470 (37%), Positives = 281/470 (59%), Gaps = 2/470 (0%)
Query: 724 VSDWQLLKLNAPEWPLITVGSIAAFLQGACFPVFALLFGFSSGIFILDNRDDIIYLADLY 783
VS ++LKLN PEWP + +G++A+ L G PVF+++F +F +++ + + A++Y
Sbjct: 231 VSLLKILKLNKPEWPFVVLGTLASVLNGTVHPVFSIIFAKIITMFGNNDKTTLKHDAEIY 290
Query: 784 SVLFVVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAIC 843
S++FV++ + +S +Q + AG +T RLRH F ++L Q+I +FD++ N+ G +
Sbjct: 291 SMIFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGGLT 350
Query: 844 ARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLMVGSIWLE 903
L+ D A++QGATG RIG++ Q +++ + +++ Y W++T + P++ + +E
Sbjct: 351 TILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGMIE 410
Query: 904 GIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVAYKT 963
++ ++ A IATEA+ +I+T+ SL E F Q +++ L+T + K
Sbjct: 411 TAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTSKKA 470
Query: 964 RWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYA 1023
+ G Y + AY + +GA L+ G M + + +V AI YGA +G++LV A
Sbjct: 471 QIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIVFTAIAYGAMAIGKTLVLA 530
Query: 1024 PSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLK 1083
P + AK+ A + ++++++P I ++ + KK GN R+V F YP RP +L+
Sbjct: 531 PEYSKAKSGAAHLFALLEKKPNI-DSRSQEGKKPDTCEGNLEFREVSFFYPCRPDVFILR 589
Query: 1084 GIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQL 1143
G+ L +E GKT+A VGSSGCGKST +QL QR YDP G + D D + L + LR Q+
Sbjct: 590 GLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKE-LNVQWLRSQI 648
Query: 1144 GVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPK 1193
+V QEPVL + S+AENIAYGDN+R V + EI AA AANIHSFI LP+
Sbjct: 649 AIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPE 698
Score = 324 bits (795), Expect = 2e-87
Identities = 190/546 (34%), Positives = 293/546 (53%), Gaps = 14/546 (2%)
Query: 88 RLVNATHEQNMEALIDDAKAMAIGMFISIGVSLVFCVLSFSLISWSALRQIT-RIRTLFL 146
+++ + L DA+ ++ +F+ +GV L A +T R+R L
Sbjct: 270 KIITMFGNNDKTTLKHDAEIYSM-IFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAF 328
Query: 147 RSVLRQDMSWYDT--DSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPL 204
+++L QD++W+D +S L + ++ ++ I+ G ++ V++ + + +F
Sbjct: 329 KAMLYQDIAWFDEKENSTGGLTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIY 388
Query: 205 GWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAFGGE 264
GW++T ++ P +T + + T + ++ + AGK A E L+++RTIV+ E
Sbjct: 389 GWEMTFLILSIAPVLAVTGMIETAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTRE 448
Query: 265 NKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSN 324
+ Y +L+ K+ G F+ Y A GF +G L+
Sbjct: 449 KAFEQMYEEMLQTQHRNTSKKAQIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAG------ 502
Query: 325 LRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKG 384
R P G ++ + ++ +I + + +F L+E++P IDS Q+G
Sbjct: 503 -RMTPEG-MFIVFTAIAYGAMAIGKTLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEG 560
Query: 385 LTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQR 444
P G++ +V F YP RP+V +L+G S+ ++ G+ VA VGSSGCGKST +QLLQR
Sbjct: 561 KKPDTCEGNLEFREVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQR 620
Query: 445 LYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIG--SPEATREEI 502
LYDP G V WLRS + +V QEPVLF +I +NIA G S +EI
Sbjct: 621 LYDPVQGQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEI 680
Query: 503 QRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSA 562
+ A A H FI LP Y+T +G +GA LSGGQKQR+AIAR+LL++P +LLLDEATSA
Sbjct: 681 KEAANAANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSA 740
Query: 563 LDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKG 622
LD SE+ VQ ALD+A GRT + V+HRLS I NAD I+ + G I EQGTH++L++ +
Sbjct: 741 LDNDSEKVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRD 800
Query: 623 FYHKLV 628
Y KLV
Sbjct: 801 IYFKLV 806
Score = 188 bits (458), Expect = 1e-46
Identities = 92/175 (52%), Positives = 125/175 (71%)
Query: 469 RSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGE 528
R +GVV QEPVLF TI +NI G + T EE++R A A A+DFI PN ++T++GE
Sbjct: 16 RDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDFIMEFPNKFNTLVGE 75
Query: 529 RGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVS 588
+GA +SGGQKQRIAIAR+L+R P +L+LDEATSALD S+ VQAAL++AS GRTTI V+
Sbjct: 76 KGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAALEKASKGRTTIVVA 135
Query: 589 HRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENKEPADIEPL 643
HRLSTI +AD I+ + G++ E+G H +LM +G Y+ LV + + K +E +
Sbjct: 136 HRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQDIKKADEQMESM 190
Score = 72.5 bits (170), Expect = 9e-12
Identities = 32/64 (50%), Positives = 46/64 (71%)
Query: 1194 AVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRMCR 1253
AV ALEKA+KGRT I +AHRLST++ ADLI + G + E+G HAEL++ +G Y+ +
Sbjct: 117 AVQAALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVM 176
Query: 1254 GQNM 1257
Q++
Sbjct: 177 SQDI 180
Score = 69.7 bits (163), Expect = 6e-11
Identities = 30/65 (46%), Positives = 45/65 (69%)
Query: 1193 KAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRMC 1252
K V AL+KA GRTC+ + HRLS +++ADLI V+ GKI E+GTH EL+ + Y+++
Sbjct: 747 KVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLV 806
Query: 1253 RGQNM 1257
Q++
Sbjct: 807 NAQSV 811
Score = 53.6 bits (123), Expect = 4e-06
Identities = 34/81 (41%), Positives = 47/81 (58%), Gaps = 4/81 (4%)
Query: 1125 LDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANI 1184
+D DIR AL + R +GVV QEPVL +++ NI YG ++ VT E+ AA+ AN
Sbjct: 2 VDENDIR-ALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDD--VTDEEMERAAREANA 58
Query: 1185 HSFIVSLP-KAVTEALEKAAK 1204
+ FI+ P K T EK A+
Sbjct: 59 YDFIMEFPNKFNTLVGEKGAQ 79
>AY090613-1|AAM09027.1| 812|Homo sapiens P-glycoprotein protein.
Length = 812
Score = 335 bits (823), Expect = 7e-91
Identities = 174/470 (37%), Positives = 281/470 (59%), Gaps = 2/470 (0%)
Query: 724 VSDWQLLKLNAPEWPLITVGSIAAFLQGACFPVFALLFGFSSGIFILDNRDDIIYLADLY 783
VS ++LKLN PEWP + +G++A+ L G PVF+++F +F +++ + + A++Y
Sbjct: 231 VSLLKILKLNKPEWPFVVLGTLASVLNGTVHPVFSIIFAKIITMFGNNDKTTLKHDAEIY 290
Query: 784 SVLFVVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAIC 843
S++FV++ + +S +Q + AG +T RLRH F ++L Q+I +FD++ N+ G +
Sbjct: 291 SMIFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGGLT 350
Query: 844 ARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLMVGSIWLE 903
L+ D A++QGATG RIG++ Q +++ + +++ Y W++T + P++ + +E
Sbjct: 351 TILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGMIE 410
Query: 904 GIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVAYKT 963
++ ++ A IATEA+ +I+T+ SL E F Q +++ L+T + K
Sbjct: 411 TAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTSKKA 470
Query: 964 RWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYA 1023
+ G Y + AY + +GA L+ G M + + +V AI YGA +G++LV A
Sbjct: 471 QIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIVFTAIAYGAMAIGKTLVLA 530
Query: 1024 PSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLK 1083
P + AK+ A + ++++++P I ++ + KK GN R+V F YP RP +L+
Sbjct: 531 PEYSKAKSGAAHLFALLEKKPNI-DSRSQEGKKPDTCEGNLEFREVSFFYPCRPDVFILR 589
Query: 1084 GIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQL 1143
G+ L +E GKT+A VGSSGCGKST +QL QR YDP G + D D + L + LR Q+
Sbjct: 590 GLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKE-LNVQWLRSQI 648
Query: 1144 GVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPK 1193
+V QEPVL + S+AENIAYGDN+R V + EI AA AANIHSFI LP+
Sbjct: 649 AIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPE 698
Score = 324 bits (795), Expect = 2e-87
Identities = 190/546 (34%), Positives = 293/546 (53%), Gaps = 14/546 (2%)
Query: 88 RLVNATHEQNMEALIDDAKAMAIGMFISIGVSLVFCVLSFSLISWSALRQIT-RIRTLFL 146
+++ + L DA+ ++ +F+ +GV L A +T R+R L
Sbjct: 270 KIITMFGNNDKTTLKHDAEIYSM-IFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAF 328
Query: 147 RSVLRQDMSWYDT--DSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPL 204
+++L QD++W+D +S L + ++ ++ I+ G ++ V++ + + +F
Sbjct: 329 KAMLYQDIAWFDEKENSTGGLTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIY 388
Query: 205 GWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAFGGE 264
GW++T ++ P +T + + T + ++ + AGK A E L+++RTIV+ E
Sbjct: 389 GWEMTFLILSIAPVLAVTGMIETAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTRE 448
Query: 265 NKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSN 324
+ Y +L+ K+ G F+ Y A GF +G L+
Sbjct: 449 KAFEQMYEEMLQTQHRNTSKKAQIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAG------ 502
Query: 325 LRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKG 384
R P G ++ + ++ +I + + +F L+E++P IDS Q+G
Sbjct: 503 -RMTPEG-MFIVFTAIAYGAMAIGKTLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEG 560
Query: 385 LTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQR 444
P G++ +V F YP RP+V +L+G S+ ++ G+ VA VGSSGCGKST +QLLQR
Sbjct: 561 KKPDTCEGNLEFREVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQR 620
Query: 445 LYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIG--SPEATREEI 502
LYDP G V WLRS + +V QEPVLF +I +NIA G S +EI
Sbjct: 621 LYDPVQGQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEI 680
Query: 503 QRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSA 562
+ A A H FI LP Y+T +G +GA LSGGQKQR+AIAR+LL++P +LLLDEATSA
Sbjct: 681 KEAANAANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSA 740
Query: 563 LDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKG 622
LD SE+ VQ ALD+A GRT + V+HRLS I NAD I+ + G I EQGTH++L++ +
Sbjct: 741 LDNDSEKVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRD 800
Query: 623 FYHKLV 628
Y KLV
Sbjct: 801 IYFKLV 806
Score = 188 bits (458), Expect = 1e-46
Identities = 92/175 (52%), Positives = 125/175 (71%)
Query: 469 RSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGE 528
R +GVV QEPVLF TI +NI G + T EE++R A A A+DFI PN ++T++GE
Sbjct: 16 RDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDFIMEFPNKFNTLVGE 75
Query: 529 RGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVS 588
+GA +SGGQKQRIAIAR+L+R P +L+LDEATSALD S+ VQAAL++AS GRTTI V+
Sbjct: 76 KGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAALEKASKGRTTIVVA 135
Query: 589 HRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENKEPADIEPL 643
HRLSTI +AD I+ + G++ E+G H +LM +G Y+ LV + + K +E +
Sbjct: 136 HRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQDIKKADEQMESM 190
Score = 72.5 bits (170), Expect = 9e-12
Identities = 32/64 (50%), Positives = 46/64 (71%)
Query: 1194 AVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRMCR 1253
AV ALEKA+KGRT I +AHRLST++ ADLI + G + E+G HAEL++ +G Y+ +
Sbjct: 117 AVQAALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVM 176
Query: 1254 GQNM 1257
Q++
Sbjct: 177 SQDI 180
Score = 69.7 bits (163), Expect = 6e-11
Identities = 30/65 (46%), Positives = 45/65 (69%)
Query: 1193 KAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRMC 1252
K V AL+KA GRTC+ + HRLS +++ADLI V+ GKI E+GTH EL+ + Y+++
Sbjct: 747 KVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLV 806
Query: 1253 RGQNM 1257
Q++
Sbjct: 807 NAQSV 811
Score = 53.6 bits (123), Expect = 4e-06
Identities = 34/81 (41%), Positives = 47/81 (58%), Gaps = 4/81 (4%)
Query: 1125 LDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANI 1184
+D DIR AL + R +GVV QEPVL +++ NI YG ++ VT E+ AA+ AN
Sbjct: 2 VDENDIR-ALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDD--VTDEEMERAAREANA 58
Query: 1185 HSFIVSLP-KAVTEALEKAAK 1204
+ FI+ P K T EK A+
Sbjct: 59 YDFIMEFPNKFNTLVGEKGAQ 79
>AF399931-1|AAQ03033.1| 832|Homo sapiens P-glycoprotein protein.
Length = 832
Score = 335 bits (823), Expect = 7e-91
Identities = 174/470 (37%), Positives = 281/470 (59%), Gaps = 2/470 (0%)
Query: 724 VSDWQLLKLNAPEWPLITVGSIAAFLQGACFPVFALLFGFSSGIFILDNRDDIIYLADLY 783
VS ++LKLN PEWP + +G++A+ L G PVF+++F +F +++ + + A++Y
Sbjct: 251 VSLLKILKLNKPEWPFVVLGTLASVLNGTVHPVFSIIFAKIITMFGNNDKTTLKHDAEIY 310
Query: 784 SVLFVVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAIC 843
S++FV++ + +S +Q + AG +T RLRH F ++L Q+I +FD++ N+ G +
Sbjct: 311 SMIFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGGLT 370
Query: 844 ARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLMVGSIWLE 903
L+ D A++QGATG RIG++ Q +++ + +++ Y W++T + P++ + +E
Sbjct: 371 TILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGMIE 430
Query: 904 GIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVAYKT 963
++ ++ A IATEA+ +I+T+ SL E F Q +++ L+T + K
Sbjct: 431 TAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTSKKA 490
Query: 964 RWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYA 1023
+ G Y + AY + +GA L+ G M + + +V AI YGA +G++LV A
Sbjct: 491 QIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIVFTAIAYGAMAIGKTLVLA 550
Query: 1024 PSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLK 1083
P + AK+ A + ++++++P I ++ + KK GN R+V F YP RP +L+
Sbjct: 551 PEYSKAKSGAAHLFALLEKKPNI-DSRSQEGKKPDTCEGNLEFREVSFFYPCRPDVFILR 609
Query: 1084 GIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQL 1143
G+ L +E GKT+A VGSSGCGKST +QL QR YDP G + D D + L + LR Q+
Sbjct: 610 GLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKE-LNVQWLRSQI 668
Query: 1144 GVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPK 1193
+V QEPVL + S+AENIAYGDN+R V + EI AA AANIHSFI LP+
Sbjct: 669 AIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPE 718
Score = 324 bits (795), Expect = 2e-87
Identities = 190/546 (34%), Positives = 293/546 (53%), Gaps = 14/546 (2%)
Query: 88 RLVNATHEQNMEALIDDAKAMAIGMFISIGVSLVFCVLSFSLISWSALRQIT-RIRTLFL 146
+++ + L DA+ ++ +F+ +GV L A +T R+R L
Sbjct: 290 KIITMFGNNDKTTLKHDAEIYSM-IFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAF 348
Query: 147 RSVLRQDMSWYDT--DSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPL 204
+++L QD++W+D +S L + ++ ++ I+ G ++ V++ + + +F
Sbjct: 349 KAMLYQDIAWFDEKENSTGGLTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIY 408
Query: 205 GWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAFGGE 264
GW++T ++ P +T + + T + ++ + AGK A E L+++RTIV+ E
Sbjct: 409 GWEMTFLILSIAPVLAVTGMIETAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTRE 468
Query: 265 NKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSN 324
+ Y +L+ K+ G F+ Y A GF +G L+
Sbjct: 469 KAFEQMYEEMLQTQHRNTSKKAQIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAG------ 522
Query: 325 LRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKG 384
R P G ++ + ++ +I + + +F L+E++P IDS Q+G
Sbjct: 523 -RMTPEG-MFIVFTAIAYGAMAIGKTLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEG 580
Query: 385 LTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQR 444
P G++ +V F YP RP+V +L+G S+ ++ G+ VA VGSSGCGKST +QLLQR
Sbjct: 581 KKPDTCEGNLEFREVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQR 640
Query: 445 LYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIG--SPEATREEI 502
LYDP G V WLRS + +V QEPVLF +I +NIA G S +EI
Sbjct: 641 LYDPVQGQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEI 700
Query: 503 QRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSA 562
+ A A H FI LP Y+T +G +GA LSGGQKQR+AIAR+LL++P +LLLDEATSA
Sbjct: 701 KEAANAANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSA 760
Query: 563 LDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKG 622
LD SE+ VQ ALD+A GRT + V+HRLS I NAD I+ + G I EQGTH++L++ +
Sbjct: 761 LDNDSEKVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRD 820
Query: 623 FYHKLV 628
Y KLV
Sbjct: 821 IYFKLV 826
Score = 208 bits (509), Expect = 7e-53
Identities = 105/208 (50%), Positives = 140/208 (67%)
Query: 436 STVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSP 495
STV+QLLQRLYDP G + R +GVV QEPVLF TI +NI G
Sbjct: 3 STVVQLLQRLYDPDDGFIMVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRD 62
Query: 496 EATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLL 555
+ T EE++R A A A+DFI PN ++T++GE+GA +SGGQKQRIAIAR+L+R P +L+
Sbjct: 63 DVTDEEMERAAREANAYDFIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILI 122
Query: 556 LDEATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHE 615
LDEATSALD S+ VQAAL++AS GRTTI V+HRLSTI +AD I+ + G++ E+G H
Sbjct: 123 LDEATSALDSESKSAVQAALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHA 182
Query: 616 DLMKAKGFYHKLVTTGNENKEPADIEPL 643
+LM +G Y+ LV + + K +E +
Sbjct: 183 ELMAKRGLYYSLVMSQDIKKADEQMESM 210
Score = 82.6 bits (195), Expect = 8e-15
Identities = 47/100 (47%), Positives = 62/100 (62%), Gaps = 4/100 (4%)
Query: 1106 STILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGD 1165
ST++QL QR YDPD GFI +D DIR AL + R +GVV QEPVL +++ NI YG
Sbjct: 3 STVVQLLQRLYDPDDGFIMVDENDIR-ALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGR 61
Query: 1166 NNRKVTMHEIVAAAKAANIHSFIVSLP-KAVTEALEKAAK 1204
++ VT E+ AA+ AN + FI+ P K T EK A+
Sbjct: 62 DD--VTDEEMERAAREANAYDFIMEFPNKFNTLVGEKGAQ 99
Score = 72.5 bits (170), Expect = 9e-12
Identities = 32/64 (50%), Positives = 46/64 (71%)
Query: 1194 AVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRMCR 1253
AV ALEKA+KGRT I +AHRLST++ ADLI + G + E+G HAEL++ +G Y+ +
Sbjct: 137 AVQAALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVM 196
Query: 1254 GQNM 1257
Q++
Sbjct: 197 SQDI 200
Score = 69.7 bits (163), Expect = 6e-11
Identities = 30/65 (46%), Positives = 45/65 (69%)
Query: 1193 KAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRMC 1252
K V AL+KA GRTC+ + HRLS +++ADLI V+ GKI E+GTH EL+ + Y+++
Sbjct: 767 KVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLV 826
Query: 1253 RGQNM 1257
Q++
Sbjct: 827 NAQSV 831
>AF319622-1|AAN76500.1| 681|Homo sapiens P-glycoprotein protein.
Length = 681
Score = 335 bits (823), Expect = 7e-91
Identities = 174/470 (37%), Positives = 281/470 (59%), Gaps = 2/470 (0%)
Query: 724 VSDWQLLKLNAPEWPLITVGSIAAFLQGACFPVFALLFGFSSGIFILDNRDDIIYLADLY 783
VS ++LKLN PEWP + +G++A+ L G PVF+++F +F +++ + + A++Y
Sbjct: 100 VSLLKILKLNKPEWPFVVLGTLASVLNGTVHPVFSIIFAKIITMFGNNDKTTLKHDAEIY 159
Query: 784 SVLFVVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAIC 843
S++FV++ + +S +Q + AG +T RLRH F ++L Q+I +FD++ N+ G +
Sbjct: 160 SMIFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGGLT 219
Query: 844 ARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLMVGSIWLE 903
L+ D A++QGATG RIG++ Q +++ + +++ Y W++T + P++ + +E
Sbjct: 220 TILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGMIE 279
Query: 904 GIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVAYKT 963
++ ++ A IATEA+ +I+T+ SL E F Q +++ L+T + K
Sbjct: 280 TAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTSKKA 339
Query: 964 RWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYA 1023
+ G Y + AY + +GA L+ G M + + +V AI YGA +G++LV A
Sbjct: 340 QIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIVFTAIAYGAMAIGKTLVLA 399
Query: 1024 PSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLK 1083
P + AK+ A + ++++++P I ++ + KK GN R+V F YP RP +L+
Sbjct: 400 PEYSKAKSGAAHLFALLEKKPNI-DSRSQEGKKPDTCEGNLEFREVSFFYPCRPDVFILR 458
Query: 1084 GIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQL 1143
G+ L +E GKT+A VGSSGCGKST +QL QR YDP G + D D + L + LR Q+
Sbjct: 459 GLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKE-LNVQWLRSQI 517
Query: 1144 GVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPK 1193
+V QEPVL + S+AENIAYGDN+R V + EI AA AANIHSFI LP+
Sbjct: 518 AIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPE 567
Score = 324 bits (795), Expect = 2e-87
Identities = 190/546 (34%), Positives = 293/546 (53%), Gaps = 14/546 (2%)
Query: 88 RLVNATHEQNMEALIDDAKAMAIGMFISIGVSLVFCVLSFSLISWSALRQIT-RIRTLFL 146
+++ + L DA+ ++ +F+ +GV L A +T R+R L
Sbjct: 139 KIITMFGNNDKTTLKHDAEIYSM-IFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAF 197
Query: 147 RSVLRQDMSWYDT--DSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPL 204
+++L QD++W+D +S L + ++ ++ I+ G ++ V++ + + +F
Sbjct: 198 KAMLYQDIAWFDEKENSTGGLTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIY 257
Query: 205 GWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAFGGE 264
GW++T ++ P +T + + T + ++ + AGK A E L+++RTIV+ E
Sbjct: 258 GWEMTFLILSIAPVLAVTGMIETAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTRE 317
Query: 265 NKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSN 324
+ Y +L+ K+ G F+ Y A GF +G L+
Sbjct: 318 KAFEQMYEEMLQTQHRNTSKKAQIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAG------ 371
Query: 325 LRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKG 384
R P G ++ + ++ +I + + +F L+E++P IDS Q+G
Sbjct: 372 -RMTPEG-MFIVFTAIAYGAMAIGKTLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEG 429
Query: 385 LTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQR 444
P G++ +V F YP RP+V +L+G S+ ++ G+ VA VGSSGCGKST +QLLQR
Sbjct: 430 KKPDTCEGNLEFREVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQR 489
Query: 445 LYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIG--SPEATREEI 502
LYDP G V WLRS + +V QEPVLF +I +NIA G S +EI
Sbjct: 490 LYDPVQGQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEI 549
Query: 503 QRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSA 562
+ A A H FI LP Y+T +G +GA LSGGQKQR+AIAR+LL++P +LLLDEATSA
Sbjct: 550 KEAANAANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSA 609
Query: 563 LDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKG 622
LD SE+ VQ ALD+A GRT + V+HRLS I NAD I+ + G I EQGTH++L++ +
Sbjct: 610 LDNDSEKVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRD 669
Query: 623 FYHKLV 628
Y KLV
Sbjct: 670 IYFKLV 675
Score = 69.7 bits (163), Expect = 6e-11
Identities = 30/65 (46%), Positives = 45/65 (69%)
Query: 1193 KAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRMC 1252
K V AL+KA GRTC+ + HRLS +++ADLI V+ GKI E+GTH EL+ + Y+++
Sbjct: 616 KVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLV 675
Query: 1253 RGQNM 1257
Q++
Sbjct: 676 NAQSV 680
Score = 51.6 bits (118), Expect = 2e-05
Identities = 20/49 (40%), Positives = 34/49 (69%)
Query: 1209 ITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRMCRGQNM 1257
+ +AHRLST++ ADLI + G + E+G HAEL++ +G Y+ + Q++
Sbjct: 1 MVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQDI 49
Score = 50.8 bits (116), Expect = 3e-05
Identities = 22/59 (37%), Positives = 37/59 (62%)
Query: 585 ITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENKEPADIEPL 643
+ V+HRLSTI +AD I+ + G++ E+G H +LM +G Y+ LV + + K +E +
Sbjct: 1 MVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQDIKKADEQMESM 59
>AY851365-1|AAW31630.1| 812|Homo sapiens ABCB5beta protein.
Length = 812
Score = 332 bits (816), Expect = 5e-90
Identities = 173/470 (36%), Positives = 280/470 (59%), Gaps = 2/470 (0%)
Query: 724 VSDWQLLKLNAPEWPLITVGSIAAFLQGACFPVFALLFGFSSGIFILDNRDDIIYLADLY 783
VS ++LKLN PEWP + +G++A+ L G PVF+++F +F +++ + + A++Y
Sbjct: 231 VSLLKILKLNKPEWPFVVLGTLASVLNGTVHPVFSIIFAKIITMFGNNDKTTLKHDAEIY 290
Query: 784 SVLFVVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAIC 843
S++FV++ + +S +Q + AG +T RLRH F ++L Q+I +FD++ N+ G +
Sbjct: 291 SMIFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGGLT 350
Query: 844 ARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLMVGSIWLE 903
L+ D A++QGATG RIG++ Q +++ + +++ Y W++T + P++ + +E
Sbjct: 351 TILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGMIE 410
Query: 904 GIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVAYKT 963
++ ++ A IATEA+ +I+T+ SL E F Q +++ L+T + K
Sbjct: 411 TAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTSKKA 470
Query: 964 RWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYA 1023
+ G Y + AY + +GA L+ G M + + +V AI YGA +G++LV A
Sbjct: 471 QIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIVFTAIAYGAMAIGKTLVLA 530
Query: 1024 PSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLK 1083
P + AK+ A + ++++++P I ++ + KK GN R+V F YP RP +L+
Sbjct: 531 PEYSKAKSGAAHLFALLEKKPNI-DSRSQEGKKPDTCEGNLEFREVSFFYPCRPDVFILR 589
Query: 1084 GIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQL 1143
G+ L +E GKT+A VGSSGCGKST +QL QR YDP G + D D + L + LR Q+
Sbjct: 590 GLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKE-LNVQWLRSQI 648
Query: 1144 GVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPK 1193
+V QEPVL + S+AENIAYGDN+R V + EI AA AANIHSFI P+
Sbjct: 649 AIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGPPE 698
Score = 321 bits (788), Expect = 1e-86
Identities = 189/546 (34%), Positives = 292/546 (53%), Gaps = 14/546 (2%)
Query: 88 RLVNATHEQNMEALIDDAKAMAIGMFISIGVSLVFCVLSFSLISWSALRQIT-RIRTLFL 146
+++ + L DA+ ++ +F+ +GV L A +T R+R L
Sbjct: 270 KIITMFGNNDKTTLKHDAEIYSM-IFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAF 328
Query: 147 RSVLRQDMSWYDT--DSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPL 204
+++L QD++W+D +S L + ++ ++ I+ G ++ V++ + + +F
Sbjct: 329 KAMLYQDIAWFDEKENSTGGLTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIY 388
Query: 205 GWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAFGGE 264
GW++T ++ P +T + + T + ++ + AGK A E L+++RTIV+ E
Sbjct: 389 GWEMTFLILSIAPVLAVTGMIETAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTRE 448
Query: 265 NKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSN 324
+ Y +L+ K+ G F+ Y A GF +G L+
Sbjct: 449 KAFEQMYEEMLQTQHRNTSKKAQIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAG------ 502
Query: 325 LRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKG 384
R P G ++ + ++ +I + + +F L+E++P IDS Q+G
Sbjct: 503 -RMTPEG-MFIVFTAIAYGAMAIGKTLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEG 560
Query: 385 LTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQR 444
P G++ +V F YP RP+V +L+G S+ ++ G+ VA VGSSGCGKST +QLLQR
Sbjct: 561 KKPDTCEGNLEFREVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQR 620
Query: 445 LYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIG--SPEATREEI 502
LYDP G V WLRS + +V QEPVLF +I +NIA G S +EI
Sbjct: 621 LYDPVQGQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEI 680
Query: 503 QRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSA 562
+ A A H FI P Y+T +G +GA LSGGQKQR+AIAR+LL++P +LLLDEATSA
Sbjct: 681 KEAANAANIHSFIEGPPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSA 740
Query: 563 LDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKG 622
LD SE+ VQ ALD+A GRT + V+HRLS I NAD I+ + G I EQGTH++L++ +
Sbjct: 741 LDNDSEKVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRD 800
Query: 623 FYHKLV 628
Y KLV
Sbjct: 801 IYFKLV 806
Score = 190 bits (462), Expect = 4e-47
Identities = 93/175 (53%), Positives = 125/175 (71%)
Query: 469 RSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGE 528
R +GVV QEPVLF TI +NI G + T EE++R A A A+DFI PN ++T++GE
Sbjct: 16 RDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDFIMEFPNKFNTLVGE 75
Query: 529 RGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVS 588
+GA +SGGQKQRIAIAR+L+R P +L+LDEATSALD SE VQAAL++AS GRTTI V+
Sbjct: 76 KGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESESAVQAALEKASKGRTTIVVA 135
Query: 589 HRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENKEPADIEPL 643
HRLSTI +AD I+ + G++ E+G H +LM +G Y+ LV + + K +E +
Sbjct: 136 HRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQDIKKADEQMESM 190
Score = 72.5 bits (170), Expect = 9e-12
Identities = 32/64 (50%), Positives = 46/64 (71%)
Query: 1194 AVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRMCR 1253
AV ALEKA+KGRT I +AHRLST++ ADLI + G + E+G HAEL++ +G Y+ +
Sbjct: 117 AVQAALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVM 176
Query: 1254 GQNM 1257
Q++
Sbjct: 177 SQDI 180
Score = 69.7 bits (163), Expect = 6e-11
Identities = 30/65 (46%), Positives = 45/65 (69%)
Query: 1193 KAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRMC 1252
K V AL+KA GRTC+ + HRLS +++ADLI V+ GKI E+GTH EL+ + Y+++
Sbjct: 747 KVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLV 806
Query: 1253 RGQNM 1257
Q++
Sbjct: 807 NAQSV 811
Score = 53.6 bits (123), Expect = 4e-06
Identities = 34/81 (41%), Positives = 47/81 (58%), Gaps = 4/81 (4%)
Query: 1125 LDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANI 1184
+D DIR AL + R +GVV QEPVL +++ NI YG ++ VT E+ AA+ AN
Sbjct: 2 VDENDIR-ALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDD--VTDEEMERAAREANA 58
Query: 1185 HSFIVSLP-KAVTEALEKAAK 1204
+ FI+ P K T EK A+
Sbjct: 59 YDFIMEFPNKFNTLVGEKGAQ 79
>AC069137-4|AAY24100.1| 451|Homo sapiens unknown protein.
Length = 451
Score = 313 bits (769), Expect = 2e-84
Identities = 166/454 (36%), Positives = 248/454 (54%), Gaps = 10/454 (2%)
Query: 181 GEKLAVVSNLVGTSVICLCTAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREMES 240
G ++ ++ N + + AF W+L+L PF ++ + T + R+ ++
Sbjct: 3 GSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLALSGATQTRMLTGFASRDKQA 62
Query: 241 YSLAGKQAEEILKSVRTIVAFGGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLT 300
+ G+ E L ++RT+ G E + +E LE + ++ G F +
Sbjct: 63 LEMVGQITNEALSNIRTVAGIGKERRFIEALETELEKPFKTAIQKANIYGFCFAFAQCIM 122
Query: 301 YSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXX 360
+ N+ + YG L+ N+ V+ ++ +V ++ ++ + +
Sbjct: 123 FIANSASYRYGGYLISNE--------GLHFSYVFRVISAVVLSATALGRAFSYTPSYAKA 174
Query: 361 XXXXXSIFHLIEREPKIDSLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVK 420
F L++R+P I G G I D +F YPSRP+ +VL G S+ +
Sbjct: 175 KISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSIS 234
Query: 421 PGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPV 480
PG+ +A VGSSGCGKST +QLL+R YDP G V +LRS++G+V QEPV
Sbjct: 235 PGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPV 294
Query: 481 LFRGTIYDNIAIG--SPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQK 538
LF +I DNI G + E E + A+ A HDF+ LP Y+T +G +G+ LS G+K
Sbjct: 295 LFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEK 354
Query: 539 QRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNAD 598
QRIAIAR+++R+P +LLLDEATSALD SE+ VQ ALD+A GRT I ++HRLSTI NAD
Sbjct: 355 QRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNAD 414
Query: 599 RIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGN 632
I M QGV++E+GTHE+LM KG Y+KLVTTG+
Sbjct: 415 IIAVMAQGVVIEKGTHEELMAQKGAYYKLVTTGS 448
Score = 225 bits (549), Expect = 1e-57
Identities = 118/340 (34%), Positives = 185/340 (54%), Gaps = 6/340 (1%)
Query: 856 ATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDER 915
A G +IG+I+ ++V V ++A S++WKL+LV F P + S + + ++
Sbjct: 1 AAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLALSGATQTRMLTGFASRDK 60
Query: 916 NAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVAYKTRWRGLVYGLGVY 975
A+E I EA+ +I+TV +G E F++ + L+ K G +
Sbjct: 61 QALEMVGQITNEALSNIRTVAGIGKERRFIEALETELEKPFKTAIQKANIYGFCFAFAQC 120
Query: 976 IPFMAYCSATVYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYAPSLNTAKACGAR 1035
I F+A ++ YG L++ + + V V A++ A LG++ Y PS AK AR
Sbjct: 121 IMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRAFSYTPSYAKAKISAAR 180
Query: 1036 ILSIIQRQPKI--HNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGK 1093
++ RQP I +N G K G D +F YP+RP +VL G+ + + G+
Sbjct: 181 FFQLLDRQPPISVYNTAGEKWDN---FQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQ 237
Query: 1094 TIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLL 1153
T+A VGSSGCGKST +QL +RFYDPD G + +D D + + + LR +G+V QEPVL
Sbjct: 238 TLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKK-VNVQFLRSNIGIVSQEPVLF 296
Query: 1154 DRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPK 1193
S+ +NI YGDN +++ M ++AAAK A +H F++SLP+
Sbjct: 297 ACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPE 336
Score = 77.0 bits (181), Expect = 4e-13
Identities = 32/59 (54%), Positives = 48/59 (81%)
Query: 1193 KAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRM 1251
K V AL+KA +GRTCI IAHRLST+++AD+I V+ +G ++E+GTH EL++ KG Y+++
Sbjct: 385 KTVQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKL 443
>BC064930-1|AAH64930.1| 738|Homo sapiens ATP-binding cassette,
sub-family B (MDR/TAP), member 10 protein.
Length = 738
Score = 304 bits (747), Expect = 1e-81
Identities = 193/560 (34%), Positives = 290/560 (51%), Gaps = 13/560 (2%)
Query: 73 LSSYLPLTATFGGGKRLVNATHEQNMEALIDDAKAMAIGMFISIGVSLVFCVLSFSLISW 132
+SS + ++A F GK +++ + D+ + +G+ + L+
Sbjct: 180 MSSVISMSAPFFLGK-IIDVIYTNPTVDYSDNLTRLCLGLSAVFLCGAAANAIRVYLMQT 238
Query: 133 SALRQITRIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVG 192
S R + R+RT S+LRQ+++++D L +++S + + + E L+
Sbjct: 239 SGQRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGA 298
Query: 193 TSVICLCTAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEIL 252
+ + + F + L +V+P I ++ Y K + +S + A + AEE +
Sbjct: 299 QASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEERI 358
Query: 253 KSVRTIVAFGGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGT 312
+VRT+ AFG E E+E+Y ++ + RK F G L+ +L + Y
Sbjct: 359 GNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEA-FARAGFFGATGLSGNLIVLSVLYKG 417
Query: 313 RLVVNDFDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIE 372
L++ VG + S L + SI ++ L+E
Sbjct: 418 GLLMGS-------AHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLE 470
Query: 373 REPKIDSLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSG 432
REPK+ + L + G + ++V F YP+RPEV + + FS+ + G ALVG SG
Sbjct: 471 REPKLPFNEGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSG 530
Query: 433 CGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAI 492
GKSTVL LL RLYDP +G++ WLRS +G V QEP+LF +I +NIA
Sbjct: 531 SGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAY 590
Query: 493 GSPE---ATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLR 549
G+ + T EEIQRVAE+A A FI P G++TV+GE+G LSGGQKQRIAIAR+LL+
Sbjct: 591 GADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLK 650
Query: 550 EPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIV 609
P +LLLDEATSALD +E VQ ALDR GRT + ++HRLSTI NA+ + +DQG I
Sbjct: 651 NPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKIT 710
Query: 610 EQGTHEDLM-KAKGFYHKLV 628
E G HE+L+ K G Y KL+
Sbjct: 711 EYGKHEELLSKPNGIYRKLM 730
Score = 175 bits (427), Expect = 6e-43
Identities = 136/429 (31%), Positives = 212/429 (49%), Gaps = 17/429 (3%)
Query: 770 LDNRDDIIYLADLYSVLFVVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEI 829
+D D++ L S +F+ AA I + L T+ G ++ RLR F+S+L+QE+
Sbjct: 205 VDYSDNLTRLCLGLSAVFLCGAAANAIRVYLMQTS----GQRIVNRLRTSLFSSILRQEV 260
Query: 830 GFFDKETNTVGAICARLSGDTAEVQGAT--GLRIGLILQGISSVVVGFLLAISYNWKLTL 887
FFDK T T G + RLS DTA + + L GL +SV + + +S N T
Sbjct: 261 AFFDK-TRT-GELINRLSSDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLA-TF 317
Query: 888 VATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQK 947
V +V P+ + ++ + G +K ++++ AT +A E + +++TV++ G E ++K
Sbjct: 318 VLSVVPPVSIIAV-IYGRYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIEK 376
Query: 948 FQDALKTACVAVAYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEY-KLVLLVN 1006
+ + + R +G + S G +L+ M +L +
Sbjct: 377 YASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLM 436
Query: 1007 EAIMYGAYMLGQSLVYAPSLNTAKACGARILSIIQRQPKIHNAVGV-KDKKDWVASGNFS 1065
A G + G S Y+ L G R+ +++R+PK+ GV ++K + G
Sbjct: 437 YAFWVGISIGGLSSFYS-ELMKGLGAGGRLWELLEREPKLPFNEGVILNEKSF--QGALE 493
Query: 1066 MRDVEFCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIEL 1125
++V F YP RP + + L + +G ALVG SG GKST+L L R YDP SG I L
Sbjct: 494 FKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISL 553
Query: 1126 DNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYG-DNNRKVTMHEIVAAAKAANI 1184
D DIR L LR ++G V QEP+L S+AENIAYG D+ VT EI A+ AN
Sbjct: 554 DGHDIRQ-LNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANA 612
Query: 1185 HSFIVSLPK 1193
+FI + P+
Sbjct: 613 VAFIRNFPQ 621
Score = 62.9 bits (146), Expect = 7e-09
Identities = 28/56 (50%), Positives = 40/56 (71%)
Query: 1195 VTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWR 1250
V EAL++ GRT + IAHRLST+K+A+++ V+D+GKI E G H EL+S +R
Sbjct: 672 VQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYR 727
>AL121990-4|CAI22012.1| 738|Homo sapiens ATP-binding cassette,
sub-family B (MDR/TAP), member 10 protein.
Length = 738
Score = 304 bits (747), Expect = 1e-81
Identities = 193/560 (34%), Positives = 290/560 (51%), Gaps = 13/560 (2%)
Query: 73 LSSYLPLTATFGGGKRLVNATHEQNMEALIDDAKAMAIGMFISIGVSLVFCVLSFSLISW 132
+SS + ++A F GK +++ + D+ + +G+ + L+
Sbjct: 180 MSSVISMSAPFFLGK-IIDVIYTNPTVDYSDNLTRLCLGLSAVFLCGAAANAIRVYLMQT 238
Query: 133 SALRQITRIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVG 192
S R + R+RT S+LRQ+++++D L +++S + + + E L+
Sbjct: 239 SGQRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGA 298
Query: 193 TSVICLCTAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEIL 252
+ + + F + L +V+P I ++ Y K + +S + A + AEE +
Sbjct: 299 QASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEERI 358
Query: 253 KSVRTIVAFGGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGT 312
+VRT+ AFG E E+E+Y ++ + RK F G L+ +L + Y
Sbjct: 359 GNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEA-FARAGFFGATGLSGNLIVLSVLYKG 417
Query: 313 RLVVNDFDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIE 372
L++ VG + S L + SI ++ L+E
Sbjct: 418 GLLMGS-------AHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLE 470
Query: 373 REPKIDSLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSG 432
REPK+ + L + G + ++V F YP+RPEV + + FS+ + G ALVG SG
Sbjct: 471 REPKLPFNEGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSG 530
Query: 433 CGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAI 492
GKSTVL LL RLYDP +G++ WLRS +G V QEP+LF +I +NIA
Sbjct: 531 SGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAY 590
Query: 493 GSPE---ATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLR 549
G+ + T EEIQRVAE+A A FI P G++TV+GE+G LSGGQKQRIAIAR+LL+
Sbjct: 591 GADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLK 650
Query: 550 EPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIV 609
P +LLLDEATSALD +E VQ ALDR GRT + ++HRLSTI NA+ + +DQG I
Sbjct: 651 NPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKIT 710
Query: 610 EQGTHEDLM-KAKGFYHKLV 628
E G HE+L+ K G Y KL+
Sbjct: 711 EYGKHEELLSKPNGIYRKLM 730
Score = 175 bits (427), Expect = 6e-43
Identities = 136/429 (31%), Positives = 212/429 (49%), Gaps = 17/429 (3%)
Query: 770 LDNRDDIIYLADLYSVLFVVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEI 829
+D D++ L S +F+ AA I + L T+ G ++ RLR F+S+L+QE+
Sbjct: 205 VDYSDNLTRLCLGLSAVFLCGAAANAIRVYLMQTS----GQRIVNRLRTSLFSSILRQEV 260
Query: 830 GFFDKETNTVGAICARLSGDTAEVQGAT--GLRIGLILQGISSVVVGFLLAISYNWKLTL 887
FFDK T T G + RLS DTA + + L GL +SV + + +S N T
Sbjct: 261 AFFDK-TRT-GELINRLSSDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLA-TF 317
Query: 888 VATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQK 947
V +V P+ + ++ + G +K ++++ AT +A E + +++TV++ G E ++K
Sbjct: 318 VLSVVPPVSIIAV-IYGRYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIEK 376
Query: 948 FQDALKTACVAVAYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEY-KLVLLVN 1006
+ + + R +G + S G +L+ M +L +
Sbjct: 377 YASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLM 436
Query: 1007 EAIMYGAYMLGQSLVYAPSLNTAKACGARILSIIQRQPKIHNAVGV-KDKKDWVASGNFS 1065
A G + G S Y+ L G R+ +++R+PK+ GV ++K + G
Sbjct: 437 YAFWVGISIGGLSSFYS-ELMKGLGAGGRLWELLEREPKLPFNEGVILNEKSF--QGALE 493
Query: 1066 MRDVEFCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIEL 1125
++V F YP RP + + L + +G ALVG SG GKST+L L R YDP SG I L
Sbjct: 494 FKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISL 553
Query: 1126 DNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYG-DNNRKVTMHEIVAAAKAANI 1184
D DIR L LR ++G V QEP+L S+AENIAYG D+ VT EI A+ AN
Sbjct: 554 DGHDIRQ-LNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANA 612
Query: 1185 HSFIVSLPK 1193
+FI + P+
Sbjct: 613 VAFIRNFPQ 621
Score = 62.9 bits (146), Expect = 7e-09
Identities = 28/56 (50%), Positives = 40/56 (71%)
Query: 1195 VTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWR 1250
V EAL++ GRT + IAHRLST+K+A+++ V+D+GKI E G H EL+S +R
Sbjct: 672 VQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYR 727
>AF216833-1|AAF78198.1| 738|Homo sapiens M-ABC2 protein protein.
Length = 738
Score = 301 bits (740), Expect = 7e-81
Identities = 193/560 (34%), Positives = 288/560 (51%), Gaps = 13/560 (2%)
Query: 73 LSSYLPLTATFGGGKRLVNATHEQNMEALIDDAKAMAIGMFISIGVSLVFCVLSFSLISW 132
+SS + ++A F GK +++ + D+ + +G+ + L+
Sbjct: 180 MSSVISMSAPFFLGK-IIDVIYTNPTVDYSDNLTRLCLGLSAVFLCGAAANAIRVYLMQT 238
Query: 133 SALRQITRIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVG 192
S R + R+RT S+LRQ+++++D L +++S + + + E L+
Sbjct: 239 SGQRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGA 298
Query: 193 TSVICLCTAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEIL 252
+ + + F + L +V+P I ++ Y K + +S + A + AEE +
Sbjct: 299 QASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEERI 358
Query: 253 KSVRTIVAFGGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGT 312
+VRT+ AFG E E+E+Y ++ + RK + GF S N I S
Sbjct: 359 GNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAVARA---GFFGATGLSGNLIVLS--- 412
Query: 313 RLVVNDFDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIE 372
V+ VG + S L + SI ++ L+E
Sbjct: 413 --VLYKGGLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLE 470
Query: 373 REPKIDSLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSG 432
REPK+ + L + G + ++V F YP+RPEV + + FS+ + G ALVG SG
Sbjct: 471 REPKLPFNEGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSG 530
Query: 433 CGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAI 492
GKSTVL LL RLY+P +G++ WLRS +G V QEP+LF +I +NIA
Sbjct: 531 SGKSTVLSLLLRLYNPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAY 590
Query: 493 GSPE---ATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLR 549
G+ + T EEIQRVAE+A A FI P G++TV+GE+G LSGGQKQRIAIAR+LL+
Sbjct: 591 GADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLK 650
Query: 550 EPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIV 609
P +LLLDEATSALD +E VQ ALDR GRT + ++HRLSTI NA+ + +DQG I
Sbjct: 651 NPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKIT 710
Query: 610 EQGTHEDLM-KAKGFYHKLV 628
E G HE+L+ K G Y KL+
Sbjct: 711 EYGKHEELLSKPNGIYRKLM 730
Score = 173 bits (422), Expect = 3e-42
Identities = 135/429 (31%), Positives = 212/429 (49%), Gaps = 17/429 (3%)
Query: 770 LDNRDDIIYLADLYSVLFVVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEI 829
+D D++ L S +F+ AA I + L T+ G ++ RLR F+S+L+QE+
Sbjct: 205 VDYSDNLTRLCLGLSAVFLCGAAANAIRVYLMQTS----GQRIVNRLRTSLFSSILRQEV 260
Query: 830 GFFDKETNTVGAICARLSGDTAEVQGAT--GLRIGLILQGISSVVVGFLLAISYNWKLTL 887
FFDK T T G + RLS DTA + + L GL +SV + + +S N T
Sbjct: 261 AFFDK-TRT-GELINRLSSDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLA-TF 317
Query: 888 VATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQK 947
V +V P+ + ++ + G +K ++++ AT +A E + +++TV++ G E ++K
Sbjct: 318 VLSVVPPVSIIAV-IYGRYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIEK 376
Query: 948 FQDALKTACVAVAYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEY-KLVLLVN 1006
+ + + R +G + S G +L+ M +L +
Sbjct: 377 YASKVDHVMQLARKEAVARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLM 436
Query: 1007 EAIMYGAYMLGQSLVYAPSLNTAKACGARILSIIQRQPKIHNAVGV-KDKKDWVASGNFS 1065
A G + G S Y+ L G R+ +++R+PK+ GV ++K + G
Sbjct: 437 YAFWVGISIGGLSSFYS-ELMKGLGAGGRLWELLEREPKLPFNEGVILNEKSF--QGALE 493
Query: 1066 MRDVEFCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIEL 1125
++V F YP RP + + L + +G ALVG SG GKST+L L R Y+P SG I L
Sbjct: 494 FKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYNPASGTISL 553
Query: 1126 DNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYG-DNNRKVTMHEIVAAAKAANI 1184
D DIR L LR ++G V QEP+L S+AENIAYG D+ VT EI A+ AN
Sbjct: 554 DGHDIRQ-LNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANA 612
Query: 1185 HSFIVSLPK 1193
+FI + P+
Sbjct: 613 VAFIRNFPQ 621
Score = 62.9 bits (146), Expect = 7e-09
Identities = 28/56 (50%), Positives = 40/56 (71%)
Query: 1195 VTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWR 1250
V EAL++ GRT + IAHRLST+K+A+++ V+D+GKI E G H EL+S +R
Sbjct: 672 VQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYR 727
>AK094636-1|BAC04392.1| 701|Homo sapiens protein ( Homo sapiens
cDNA FLJ37317 fis, clone BRAMY2017455, highly similar to
Homo sapiens ATP-binding cassette protein M-ABC1 mRNA.
).
Length = 701
Score = 301 bits (739), Expect = 1e-80
Identities = 201/537 (37%), Positives = 289/537 (53%), Gaps = 23/537 (4%)
Query: 100 ALIDDAKAMAIGMFISIGVSLVFCVLSFSLISWSALRQITRIRTLFLRSVLRQDMSWYDT 159
+ + +++ ++ + I GV + L+S R +R S+LRQD++++D
Sbjct: 152 SFMTESQNLSTHLLILYGVQGLLTFGYLVLLSHVGERMAVDMRRALFSSLLRQDITFFDA 211
Query: 160 DSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVI--CLCTAFPLGWQLTLACAAVMP 217
+ L S+++ ++ K KL + L + + CL + L +LTL P
Sbjct: 212 NKTGQLVSRLTTDVQEFKSSF--KLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATP 269
Query: 218 FSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAFGGENKEVERYRRLLEP 277
+ + + K S + E + A A+E L +VRT+ AF E +E ERY LE
Sbjct: 270 ALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEA 329
Query: 278 ----AEEFGRKRGLFTGLGN-GFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGA 332
AEE GR LF GL N FN ++ +L F+ G+ LV T +L + V A
Sbjct: 330 CRCRAEELGRGIALFQGLSNIAFNCMVLGTL----FTGGS-LVAGQQLTGGDLMSFLV-A 383
Query: 333 VYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPRRVVG 392
++ S MA S+ F + G +F + P I + ++ G
Sbjct: 384 SQTVQRS--MANLSVLFGQV-VRGLSAGAR----VFEYMALNPCIPLSGGCCVPKEQLRG 436
Query: 393 DILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGS 452
+ ++V F YP RP +VLK F++ + PG+ VALVG SG GK+TV LL+R YDP AG
Sbjct: 437 SVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGV 496
Query: 453 VXXXXXXXXXXXXSWLRSSL-GVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYA 511
V SWLR + G + QEPVLF TI +NI G EA+ EE+ A A A
Sbjct: 497 VMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIMENIRFGKLEASDEEVYTAAREANA 556
Query: 512 HDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV 571
H+FI+ P GY+TV+GERG +LSGGQKQR+AIAR+L+++P VL+LDEATSALD SER V
Sbjct: 557 HEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERVV 616
Query: 572 QAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLV 628
Q ALDRAS GRT + ++HRLST+ A I+ M G + E GTHE+L+K G Y +L+
Sbjct: 617 QEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELI 673
Score = 158 bits (383), Expect = 1e-37
Identities = 127/418 (30%), Positives = 208/418 (49%), Gaps = 21/418 (5%)
Query: 784 SVLFVVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAIC 843
S +++ V G+ + G +M +R F+SLL+Q+I FFD N G +
Sbjct: 161 STHLLILYGVQGLLTFGYLVLLSHVGERMAVDMRRALFSSLLRQDITFFD--ANKTGQLV 218
Query: 844 ARLSGDTAEVQGATGLRIGLILQGISSV--VVGFLLAISY-NWKLTLVATVFLPLMVGSI 900
+RL+ D E + + L +I QG+ S V G L+++S + +LTL+ V P ++G
Sbjct: 219 SRLTTDVQEFKSSFKL---VISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMGVG 275
Query: 901 WLEGIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVA 960
L G +K + + A +A EA+ +++TV++ +E +++ L+
Sbjct: 276 TLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAE 335
Query: 961 YKTRWRGLVYGLGVYIPFMAYCSATVY-GAVLVAYGEM---EYKLVLLVNEAIMYGAYML 1016
R L GL I F T++ G LVA ++ + L+ ++ + M
Sbjct: 336 ELGRGIALFQGLS-NIAFNCMVLGTLFTGGSLVAGQQLTGGDLMSFLVASQTVQRS--MA 392
Query: 1017 GQSLVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTR 1076
S+++ + A GAR+ + P I + G K+ + G+ + ++V F YP R
Sbjct: 393 NLSVLFGQVVRGLSA-GARVFEYMALNPCIPLSGGCCVPKEQLR-GSVTFQNVCFSYPCR 450
Query: 1077 PSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTI 1136
P VLK L + GK +ALVG SG GK+T+ L +RFYDP +G + LD RD+R+ L
Sbjct: 451 PGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRT-LDP 509
Query: 1137 PRLRRQ-LGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPK 1193
LR Q +G + QEPVL ++ ENI +G + + E+ AA+ AN H FI S P+
Sbjct: 510 SWLRGQVVGFISQEPVLFGTTIMENIRFG--KLEASDEEVYTAAREANAHEFITSFPE 565
Score = 61.3 bits (142), Expect = 2e-08
Identities = 30/63 (47%), Positives = 41/63 (65%)
Query: 1193 KAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRMC 1252
+ V EAL++A+ GRT + IAHRLSTV+ A I V+ G++ E GTH EL+ G Y +
Sbjct: 614 RVVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELI 673
Query: 1253 RGQ 1255
R Q
Sbjct: 674 RRQ 676
>BC141814-1|AAI41815.1| 718|Homo sapiens ATP-binding cassette,
sub-family B (MDR/TAP), member 8 protein.
Length = 718
Score = 300 bits (737), Expect = 2e-80
Identities = 198/537 (36%), Positives = 286/537 (53%), Gaps = 23/537 (4%)
Query: 100 ALIDDAKAMAIGMFISIGVSLVFCVLSFSLISWSALRQITRIRTLFLRSVLRQDMSWYDT 159
+ + +++ ++ + I GV + L+S R +R S+LRQD++++D
Sbjct: 169 SFMTESQNLSTHLLILYGVQGLLTFGYLVLLSHVGERMAVDMRRALFSSLLRQDITFFDA 228
Query: 160 DSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVI--CLCTAFPLGWQLTLACAAVMP 217
+ L S+++ ++ K KL + L + + CL + L +LTL P
Sbjct: 229 NKTGQLVSRLTTDVQEFKSSF--KLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATP 286
Query: 218 FSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAFGGENKEVERYRRLLEP 277
+ + + K S + E + A A+E L +VRT+ AF E +E ERY LE
Sbjct: 287 ALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEA 346
Query: 278 ----AEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSY-GTRLVVNDFDTDSNLRQYPVGA 332
AEE GR LF GL N + ++ +G + G LV T +L + V A
Sbjct: 347 CRCRAEELGRGIALFQGLSN-----IAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLV-A 400
Query: 333 VYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPRRVVG 392
++ S MA S+ F + G +F + P I + ++ G
Sbjct: 401 SQTVQRS--MANLSVLFGQV-VRGLSAGAR----VFEYMALNPCIPLSGGCCVPKEQLRG 453
Query: 393 DILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGS 452
+ ++V F YP RP +VLK F++ + PG+ VALVG SG GK+TV LL+R YDP AG
Sbjct: 454 SVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGV 513
Query: 453 VXXXXXXXXXXXXSWLRSSL-GVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYA 511
V SWLR + G + QEPVLF TI +NI G EA+ EE+ A A A
Sbjct: 514 VMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIMENIRFGKLEASDEEVYTAAREANA 573
Query: 512 HDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV 571
H+FI+ P GY+TV+GERG +LSGGQKQR+AIAR+L+++P VL+LDEATSALD SER V
Sbjct: 574 HEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERVV 633
Query: 572 QAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLV 628
Q ALDRAS GRT + ++HRLST+ A I+ M G + E GTHE+L+K G Y +L+
Sbjct: 634 QEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELI 690
Score = 158 bits (383), Expect = 1e-37
Identities = 127/418 (30%), Positives = 208/418 (49%), Gaps = 21/418 (5%)
Query: 784 SVLFVVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAIC 843
S +++ V G+ + G +M +R F+SLL+Q+I FFD N G +
Sbjct: 178 STHLLILYGVQGLLTFGYLVLLSHVGERMAVDMRRALFSSLLRQDITFFD--ANKTGQLV 235
Query: 844 ARLSGDTAEVQGATGLRIGLILQGISSV--VVGFLLAISY-NWKLTLVATVFLPLMVGSI 900
+RL+ D E + + L +I QG+ S V G L+++S + +LTL+ V P ++G
Sbjct: 236 SRLTTDVQEFKSSFKL---VISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMGVG 292
Query: 901 WLEGIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVA 960
L G +K + + A +A EA+ +++TV++ +E +++ L+
Sbjct: 293 TLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAE 352
Query: 961 YKTRWRGLVYGLGVYIPFMAYCSATVY-GAVLVAYGEM---EYKLVLLVNEAIMYGAYML 1016
R L GL I F T++ G LVA ++ + L+ ++ + M
Sbjct: 353 ELGRGIALFQGLS-NIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRS--MA 409
Query: 1017 GQSLVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTR 1076
S+++ + A GAR+ + P I + G K+ + G+ + ++V F YP R
Sbjct: 410 NLSVLFGQVVRGLSA-GARVFEYMALNPCIPLSGGCCVPKEQLR-GSVTFQNVCFSYPCR 467
Query: 1077 PSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTI 1136
P VLK L + GK +ALVG SG GK+T+ L +RFYDP +G + LD RD+R+ L
Sbjct: 468 PGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRT-LDP 526
Query: 1137 PRLRRQ-LGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPK 1193
LR Q +G + QEPVL ++ ENI +G + + E+ AA+ AN H FI S P+
Sbjct: 527 SWLRGQVVGFISQEPVLFGTTIMENIRFG--KLEASDEEVYTAAREANAHEFITSFPE 582
Score = 61.3 bits (142), Expect = 2e-08
Identities = 30/63 (47%), Positives = 41/63 (65%)
Query: 1193 KAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRMC 1252
+ V EAL++A+ GRT + IAHRLSTV+ A I V+ G++ E GTH EL+ G Y +
Sbjct: 631 RVVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELI 690
Query: 1253 RGQ 1255
R Q
Sbjct: 691 RRQ 693
>AK222911-1|BAD96631.1| 718|Homo sapiens ATP-binding cassette,
sub-family B, member 8 variant protein.
Length = 718
Score = 300 bits (737), Expect = 2e-80
Identities = 198/537 (36%), Positives = 286/537 (53%), Gaps = 23/537 (4%)
Query: 100 ALIDDAKAMAIGMFISIGVSLVFCVLSFSLISWSALRQITRIRTLFLRSVLRQDMSWYDT 159
+ + +++ ++ + I GV + L+S R +R S+LRQD++++D
Sbjct: 169 SFMTESQNLSTHLLILYGVQGLLTFGYLVLLSHVGERMAVDMRRALFSSLLRQDITFFDA 228
Query: 160 DSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVI--CLCTAFPLGWQLTLACAAVMP 217
+ L S+++ ++ K KL + L + + CL + L +LTL P
Sbjct: 229 NKTGQLVSRLTTDVQEFKSSF--KLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATP 286
Query: 218 FSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAFGGENKEVERYRRLLEP 277
+ + + K S + E + A A+E L +VRT+ AF E +E ERY LE
Sbjct: 287 ALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEA 346
Query: 278 ----AEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSY-GTRLVVNDFDTDSNLRQYPVGA 332
AEE GR LF GL N + ++ +G + G LV T +L + V A
Sbjct: 347 CRCRAEELGRGIALFQGLSN-----IAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLV-A 400
Query: 333 VYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPRRVVG 392
++ S MA S+ F + G +F + P I + ++ G
Sbjct: 401 SQTVQRS--MANLSVLFGQV-VRGLSAGAR----VFEYMALNPCIPLSGGCCVPKEQLRG 453
Query: 393 DILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGS 452
+ ++V F YP RP +VLK F++ + PG+ VALVG SG GK+TV LL+R YDP AG
Sbjct: 454 SVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGV 513
Query: 453 VXXXXXXXXXXXXSWLRSSL-GVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYA 511
V SWLR + G + QEPVLF TI +NI G EA+ EE+ A A A
Sbjct: 514 VMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIMENIRFGKLEASDEEVYTAAREANA 573
Query: 512 HDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV 571
H+FI+ P GY+TV+GERG +LSGGQKQR+AIAR+L+++P VL+LDEATSALD SER V
Sbjct: 574 HEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERVV 633
Query: 572 QAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLV 628
Q ALDRAS GRT + ++HRLST+ A I+ M G + E GTHE+L+K G Y +L+
Sbjct: 634 QEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELI 690
Score = 158 bits (383), Expect = 1e-37
Identities = 127/418 (30%), Positives = 208/418 (49%), Gaps = 21/418 (5%)
Query: 784 SVLFVVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAIC 843
S +++ V G+ + G +M +R F+SLL+Q+I FFD N G +
Sbjct: 178 STHLLILYGVQGLLTFGYLVLLSHVGERMAVDMRRALFSSLLRQDITFFD--ANKTGQLV 235
Query: 844 ARLSGDTAEVQGATGLRIGLILQGISSV--VVGFLLAISY-NWKLTLVATVFLPLMVGSI 900
+RL+ D E + + L +I QG+ S V G L+++S + +LTL+ V P ++G
Sbjct: 236 SRLTTDVQEFKSSFKL---VISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMGVG 292
Query: 901 WLEGIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVA 960
L G +K + + A +A EA+ +++TV++ +E +++ L+
Sbjct: 293 TLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAE 352
Query: 961 YKTRWRGLVYGLGVYIPFMAYCSATVY-GAVLVAYGEM---EYKLVLLVNEAIMYGAYML 1016
R L GL I F T++ G LVA ++ + L+ ++ + M
Sbjct: 353 ELGRGIALFQGLS-NIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRS--MA 409
Query: 1017 GQSLVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTR 1076
S+++ + A GAR+ + P I + G K+ + G+ + ++V F YP R
Sbjct: 410 NLSVLFGQVVRGLSA-GARVFEYMALNPCIPLSGGCCVPKEQLR-GSVTFQNVCFSYPCR 467
Query: 1077 PSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTI 1136
P VLK L + GK +ALVG SG GK+T+ L +RFYDP +G + LD RD+R+ L
Sbjct: 468 PGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRT-LDP 526
Query: 1137 PRLRRQ-LGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPK 1193
LR Q +G + QEPVL ++ ENI +G + + E+ AA+ AN H FI S P+
Sbjct: 527 SWLRGQVVGFISQEPVLFGTTIMENIRFG--KLEASDEEVYTAAREANAHEFITSFPE 582
Score = 61.3 bits (142), Expect = 2e-08
Identities = 30/63 (47%), Positives = 41/63 (65%)
Query: 1193 KAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRMC 1252
+ V EAL++A+ GRT + IAHRLSTV+ A I V+ G++ E GTH EL+ G Y +
Sbjct: 631 RVVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELI 690
Query: 1253 RGQ 1255
R Q
Sbjct: 691 RRQ 693
>AK002018-1|BAA92038.1| 735|Homo sapiens protein ( Homo sapiens
cDNA FLJ11156 fis, clone PLACE1006956, weakly similar to
ATP-DEPENDENT PERMEASE MDL1. ).
Length = 735
Score = 300 bits (737), Expect = 2e-80
Identities = 198/537 (36%), Positives = 286/537 (53%), Gaps = 23/537 (4%)
Query: 100 ALIDDAKAMAIGMFISIGVSLVFCVLSFSLISWSALRQITRIRTLFLRSVLRQDMSWYDT 159
+ + +++ ++ + I GV + L+S R +R S+LRQD++++D
Sbjct: 186 SFMTESQNLSTHLLILYGVQGLLTFGYLVLLSHVGERMAVDMRRALFSSLLRQDITFFDA 245
Query: 160 DSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVI--CLCTAFPLGWQLTLACAAVMP 217
+ L S+++ ++ K KL + L + + CL + L +LTL P
Sbjct: 246 NKTGQLVSRLTTDVQEFKSSF--KLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATP 303
Query: 218 FSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAFGGENKEVERYRRLLEP 277
+ + + K S + E + A A+E L +VRT+ AF E +E ERY LE
Sbjct: 304 ALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEA 363
Query: 278 ----AEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSY-GTRLVVNDFDTDSNLRQYPVGA 332
AEE GR LF GL N + ++ +G + G LV T +L + V A
Sbjct: 364 CHCRAEELGRGIALFQGLSN-----IAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLV-A 417
Query: 333 VYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPRRVVG 392
++ S MA S+ F + G +F + P I + ++ G
Sbjct: 418 SQTVQRS--MANLSVLFGQV-VRGLSAGAR----VFEYMALNPCIPLSGGCCVPKEQLRG 470
Query: 393 DILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGS 452
+ ++V F YP RP +VLK F++ + PG+ VALVG SG GK+TV LL+R YDP AG
Sbjct: 471 SVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGV 530
Query: 453 VXXXXXXXXXXXXSWLRSSL-GVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYA 511
V SWLR + G + QEPVLF TI +NI G EA+ EE+ A A A
Sbjct: 531 VMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIMENIRFGKLEASDEEVYTAAREANA 590
Query: 512 HDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV 571
H+FI+ P GY+TV+GERG +LSGGQKQR+AIAR+L+++P VL+LDEATSALD SER V
Sbjct: 591 HEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERVV 650
Query: 572 QAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLV 628
Q ALDRAS GRT + ++HRLST+ A I+ M G + E GTHE+L+K G Y +L+
Sbjct: 651 QEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELI 707
Score = 158 bits (383), Expect = 1e-37
Identities = 127/418 (30%), Positives = 208/418 (49%), Gaps = 21/418 (5%)
Query: 784 SVLFVVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAIC 843
S +++ V G+ + G +M +R F+SLL+Q+I FFD N G +
Sbjct: 195 STHLLILYGVQGLLTFGYLVLLSHVGERMAVDMRRALFSSLLRQDITFFD--ANKTGQLV 252
Query: 844 ARLSGDTAEVQGATGLRIGLILQGISSV--VVGFLLAISY-NWKLTLVATVFLPLMVGSI 900
+RL+ D E + + L +I QG+ S V G L+++S + +LTL+ V P ++G
Sbjct: 253 SRLTTDVQEFKSSFKL---VISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMGVG 309
Query: 901 WLEGIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVA 960
L G +K + + A +A EA+ +++TV++ +E +++ L+
Sbjct: 310 TLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACHCRAE 369
Query: 961 YKTRWRGLVYGLGVYIPFMAYCSATVY-GAVLVAYGEM---EYKLVLLVNEAIMYGAYML 1016
R L GL I F T++ G LVA ++ + L+ ++ + M
Sbjct: 370 ELGRGIALFQGLS-NIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRS--MA 426
Query: 1017 GQSLVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTR 1076
S+++ + A GAR+ + P I + G K+ + G+ + ++V F YP R
Sbjct: 427 NLSVLFGQVVRGLSA-GARVFEYMALNPCIPLSGGCCVPKEQLR-GSVTFQNVCFSYPCR 484
Query: 1077 PSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTI 1136
P VLK L + GK +ALVG SG GK+T+ L +RFYDP +G + LD RD+R+ L
Sbjct: 485 PGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRT-LDP 543
Query: 1137 PRLRRQ-LGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPK 1193
LR Q +G + QEPVL ++ ENI +G + + E+ AA+ AN H FI S P+
Sbjct: 544 SWLRGQVVGFISQEPVLFGTTIMENIRFG--KLEASDEEVYTAAREANAHEFITSFPE 599
Score = 61.3 bits (142), Expect = 2e-08
Identities = 30/63 (47%), Positives = 41/63 (65%)
Query: 1193 KAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRMC 1252
+ V EAL++A+ GRT + IAHRLSTV+ A I V+ G++ E GTH EL+ G Y +
Sbjct: 648 RVVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELI 707
Query: 1253 RGQ 1255
R Q
Sbjct: 708 RRQ 710
>X06181-1|CAA29547.1| 431|Homo sapiens P-glycoprotein (431 AA)
protein.
Length = 431
Score = 297 bits (728), Expect = 2e-79
Identities = 177/440 (40%), Positives = 249/440 (56%), Gaps = 23/440 (5%)
Query: 208 LTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAFGGENKE 267
LTL AV+P ++ I ++ R+ + AGK A E ++++RT+V+ E K
Sbjct: 1 LTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKF 60
Query: 268 VERY-RRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLR 326
Y +L P +K ++ G+ + Y A F +G L+VN ++R
Sbjct: 61 ESMYVEKLYGPYRNSVQKAHIY-GITFSISQAFMYFSYAGCFRFGAYLIVN-----GHMR 114
Query: 327 QYPVGAVYS-ILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGL 385
V V+S I+F + +F + +F L ER+P IDS ++GL
Sbjct: 115 FRDVILVFSAIVFGAVALGHASSFA----PDYAKAKLSAAHLFMLFERQPLIDSYSEEGL 170
Query: 386 TPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRL 445
P + G+I +V F YP+R V VL+G S+ VK G+ +ALVGSSGCGKSTV+QLL+R
Sbjct: 171 KPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERF 230
Query: 446 YDPQAGSVXXXXXX-------XXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIG--SPE 496
YDP AG+V WLR+ LG+V QEP+LF +I +NIA G S
Sbjct: 231 YDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRV 290
Query: 497 ATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLL 556
+++EI A+ A H FI LP+ Y+T +G++G LSGGQKQRIAIAR+L+R+P +LLL
Sbjct: 291 VSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLL 350
Query: 557 DEATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHED 616
DEATSALD SE+ VQ ALD+A GRT I ++HRLSTI NAD I+ G + E GTH+
Sbjct: 351 DEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQ 410
Query: 617 LMKAKGFYHKLVT--TGNEN 634
L+ KG Y +V+ G +N
Sbjct: 411 LLAQKGIYFSMVSVQAGTQN 430
Score = 219 bits (535), Expect = 5e-56
Identities = 129/318 (40%), Positives = 191/318 (60%), Gaps = 15/318 (4%)
Query: 885 LTLVATVFLPLMVGSIWLE-GIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETV 943
LTL+ +P++ S +E +++ A+ D++ +E+A IATEA+ +I+TV SL E
Sbjct: 1 LTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKE-LEAAGKIATEAIENIRTVVSLTQERK 59
Query: 944 FLQKFQDALKTACVAVAYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEYKLVL 1003
F + + L K G+ + + + +Y +GA L+ G M ++ V+
Sbjct: 60 FESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVI 119
Query: 1004 LVNEAIMYGAYMLGQSLVYAPSLNTAKACGARILSIIQRQPKI--HNAVGVKDKKDWVAS 1061
LV AI++GA LG + +AP AK A + + +RQP I ++ G+K K
Sbjct: 120 LVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDK---FE 176
Query: 1062 GNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDP--- 1118
GN + +V F YPTR + VL+G+ L+++ G+T+ALVGSSGCGKST++QL +RFYDP
Sbjct: 177 GNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAG 236
Query: 1119 ----DSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHE 1174
D GF LD ++ + L + LR QLG+V QEP+L D S+AENIAYGDN+R V+ E
Sbjct: 237 TVFVDFGFQLLDGQEAKK-LNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDE 295
Query: 1175 IVAAAKAANIHSFIVSLP 1192
IV+AAKAANIH FI +LP
Sbjct: 296 IVSAAKAANIHPFIETLP 313
Score = 77.0 bits (181), Expect = 4e-13
Identities = 34/59 (57%), Positives = 45/59 (76%)
Query: 1193 KAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRM 1251
K V EAL+KA +GRTCI IAHRLST+++ADLI V G++ E GTH +L++ KG Y+ M
Sbjct: 363 KVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSM 421
>AF047690-1|AAD15748.1| 718|Homo sapiens ATP-binding cassette
protein M-ABC1 protein.
Length = 718
Score = 297 bits (728), Expect = 2e-79
Identities = 197/537 (36%), Positives = 285/537 (53%), Gaps = 23/537 (4%)
Query: 100 ALIDDAKAMAIGMFISIGVSLVFCVLSFSLISWSALRQITRIRTLFLRSVLRQDMSWYDT 159
+ + +++ ++ + I GV + L+S R +R S+LRQ+++++D
Sbjct: 169 SFMTESQNLSTHLLILYGVQGLLTFGYLVLLSHVGERMAVDMRRALFSSLLRQNITFFDA 228
Query: 160 DSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVI--CLCTAFPLGWQLTLACAAVMP 217
+ L S+++ ++ K KL + L S + CL + L +LTL P
Sbjct: 229 NKTGQLVSRLTTDVQEFKSSF--KLVISQGLRSCSQVAGCLVSLSMLSTRLTLLLMVATP 286
Query: 218 FSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAFGGENKEVERYRRLLEP 277
+ + + K S + E + A A+E L +VRT+ A E +E ERY LE
Sbjct: 287 ALMGVGTLMGSGLRKLSRQCQEHIARAMGVADEALGNVRTVRALAMEQREEERYGAELEA 346
Query: 278 ----AEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSY-GTRLVVNDFDTDSNLRQYPVGA 332
AEE GR LF GL N + ++ +G + G LV T +L + V A
Sbjct: 347 CRCRAEELGRGIALFQGLSN-----IAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLV-A 400
Query: 333 VYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPRRVVG 392
++ S MA S+ F + G +F + P I + ++ G
Sbjct: 401 SQTVQRS--MANLSVLFGQV-VRGLSAGAR----VFEYMALNPCIPLSGGCCVPKEQLRG 453
Query: 393 DILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGS 452
+ ++V F YP RP +VLK F++ + PG+ VALVG SG GK+TV LL+R YDP AG
Sbjct: 454 SVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGV 513
Query: 453 VXXXXXXXXXXXXSWLRSSL-GVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYA 511
V SWLR + G + QEPVLF TI +NI G EA+ EE+ A A A
Sbjct: 514 VMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIMENIRFGKLEASDEEVYTAAREANA 573
Query: 512 HDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV 571
H+FI+ P GY+TV+GERG +LSGGQKQR+AIAR+L+++P VL+LDEATSALD SER V
Sbjct: 574 HEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERVV 633
Query: 572 QAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLV 628
Q ALDRAS GRT + ++HRLST+ A I+ M G + E GTHE+L+K G Y +L+
Sbjct: 634 QEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELI 690
Score = 159 bits (386), Expect = 6e-38
Identities = 127/416 (30%), Positives = 206/416 (49%), Gaps = 17/416 (4%)
Query: 784 SVLFVVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAIC 843
S +++ V G+ + G +M +R F+SLL+Q I FFD N G +
Sbjct: 178 STHLLILYGVQGLLTFGYLVLLSHVGERMAVDMRRALFSSLLRQNITFFD--ANKTGQLV 235
Query: 844 ARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISY-NWKLTLVATVFLPLMVGSIWL 902
+RL+ D E + + L I L+ S V G L+++S + +LTL+ V P ++G L
Sbjct: 236 SRLTTDVQEFKSSFKLVISQGLRSCSQVA-GCLVSLSMLSTRLTLLLMVATPALMGVGTL 294
Query: 903 EGIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVAYK 962
G +K + + A +A EA+ +++TV++L +E +++ L+
Sbjct: 295 MGSGLRKLSRQCQEHIARAMGVADEALGNVRTVRALAMEQREEERYGAELEACRCRAEEL 354
Query: 963 TRWRGLVYGLGVYIPFMAYCSATVY-GAVLVAYGEM---EYKLVLLVNEAIMYGAYMLGQ 1018
R L GL I F T++ G LVA ++ + L+ ++ + M
Sbjct: 355 GRGIALFQGLS-NIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRS--MANL 411
Query: 1019 SLVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPS 1078
S+++ + A GAR+ + P I + G K+ + G+ + ++V F YP RP
Sbjct: 412 SVLFGQVVRGLSA-GARVFEYMALNPCIPLSGGCCVPKEQLR-GSVTFQNVCFSYPCRPG 469
Query: 1079 QRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPR 1138
VLK L + GK +ALVG SG GK+T+ L +RFYDP +G + LD RD+R+ L
Sbjct: 470 FEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRT-LDPSW 528
Query: 1139 LRRQ-LGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPK 1193
LR Q +G + QEPVL ++ ENI +G + + E+ AA+ AN H FI S P+
Sbjct: 529 LRGQVVGFISQEPVLFGTTIMENIRFG--KLEASDEEVYTAAREANAHEFITSFPE 582
Score = 61.3 bits (142), Expect = 2e-08
Identities = 30/63 (47%), Positives = 41/63 (65%)
Query: 1193 KAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRMC 1252
+ V EAL++A+ GRT + IAHRLSTV+ A I V+ G++ E GTH EL+ G Y +
Sbjct: 631 RVVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELI 690
Query: 1253 RGQ 1255
R Q
Sbjct: 691 RRQ 693
>AB013380-1|BAB20265.1| 737|Homo sapiens mono ATP-binding cassette
protein protein.
Length = 737
Score = 291 bits (714), Expect = 1e-77
Identities = 189/560 (33%), Positives = 286/560 (51%), Gaps = 14/560 (2%)
Query: 73 LSSYLPLTATFGGGKRLVNATHEQNMEALIDDAKAMAIGMFISIGVSLVFCVLSFSLISW 132
+SS + ++A F GK +++ + D+ + +G+ + L+
Sbjct: 180 MSSVISMSAPFFLGK-IIDVIYTNPTVDYSDNLTRLCLGLSAVFLCGAAANAIRVYLMQT 238
Query: 133 SALRQITRIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVG 192
S R + R+RT S+LRQ+++++D L +++S + + + E L+
Sbjct: 239 SGQRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGA 298
Query: 193 TSVICLCTAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEIL 252
+ + + F + L +V+P I ++ Y K + +S + A + AEE +
Sbjct: 299 QASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEERI 358
Query: 253 KSVRTIVAFGGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGT 312
+VRT+ AFG E E+E+Y ++ + RK F G L+ +L + Y
Sbjct: 359 GNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEA-FARAGFFGATGLSGNLIVLSVLYKG 417
Query: 313 RLVVNDFDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIE 372
L++ VG + S L + SI ++ L+E
Sbjct: 418 GLLMGS-------AHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLE 470
Query: 373 REPKIDSLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSG 432
REPK+ + L + G + ++V F YP+RPEV + + FS+ + G ALVG SG
Sbjct: 471 REPKLPFNEGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSG 530
Query: 433 CGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAI 492
GKSTVL LL RLYDP +G++ WLRS +G V QEP+LF +I +NIA
Sbjct: 531 SGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAY 590
Query: 493 GSPE---ATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLR 549
G+ + T EEIQR + A FI P G++TV+GE+G LSGGQKQRIAIAR+LL+
Sbjct: 591 GADDPSSVTAEEIQRGLK-GQAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLK 649
Query: 550 EPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIV 609
P +LLLDEATSALD +E VQ ALDR GRT + ++HRLSTI NA+ + +DQG I
Sbjct: 650 NPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKIT 709
Query: 610 EQGTHEDLM-KAKGFYHKLV 628
E G HE+L+ K G Y KL+
Sbjct: 710 EYGKHEELLSKPNGIYRKLM 729
Score = 168 bits (409), Expect = 9e-41
Identities = 134/429 (31%), Positives = 210/429 (48%), Gaps = 18/429 (4%)
Query: 770 LDNRDDIIYLADLYSVLFVVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEI 829
+D D++ L S +F+ AA I + L T+ G ++ RLR F+S+L+QE+
Sbjct: 205 VDYSDNLTRLCLGLSAVFLCGAAANAIRVYLMQTS----GQRIVNRLRTSLFSSILRQEV 260
Query: 830 GFFDKETNTVGAICARLSGDTAEVQGAT--GLRIGLILQGISSVVVGFLLAISYNWKLTL 887
FFDK T T G + RLS DTA + + L GL +SV + + +S N T
Sbjct: 261 AFFDK-TRT-GELINRLSSDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLA-TF 317
Query: 888 VATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQK 947
V +V P+ + ++ + G +K ++++ AT +A E + +++TV++ G E ++K
Sbjct: 318 VLSVVPPVSIIAV-IYGRYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIEK 376
Query: 948 FQDALKTACVAVAYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEY-KLVLLVN 1006
+ + + R +G + S G +L+ M +L +
Sbjct: 377 YASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLM 436
Query: 1007 EAIMYGAYMLGQSLVYAPSLNTAKACGARILSIIQRQPKIHNAVGV-KDKKDWVASGNFS 1065
A G + G S Y+ L G R+ +++R+PK+ GV ++K + G
Sbjct: 437 YAFWVGISIGGLSSFYS-ELMKGLGAGGRLWELLEREPKLPFNEGVILNEKSF--QGALE 493
Query: 1066 MRDVEFCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIEL 1125
++V F YP RP + + L + +G ALVG SG GKST+L L R YDP SG I L
Sbjct: 494 FKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISL 553
Query: 1126 DNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYG-DNNRKVTMHEIVAAAKAANI 1184
D DIR L LR ++G V QEP+L S+AENIAYG D+ VT EI K +
Sbjct: 554 DGHDIRQ-LNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRGLKGQAV 612
Query: 1185 HSFIVSLPK 1193
+FI + P+
Sbjct: 613 -AFIRNFPQ 620
Score = 62.9 bits (146), Expect = 7e-09
Identities = 28/56 (50%), Positives = 40/56 (71%)
Query: 1195 VTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWR 1250
V EAL++ GRT + IAHRLST+K+A+++ V+D+GKI E G H EL+S +R
Sbjct: 671 VQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYR 726
>AK172794-1|BAD18770.1| 433|Homo sapiens protein ( Homo sapiens
cDNA FLJ23955 fis, clone HEP11276, highly similar to
Homo sapiens ATP-binding cassette, sub-family B
(MDR/TAP), member ).
Length = 433
Score = 281 bits (690), Expect = 8e-75
Identities = 170/424 (40%), Positives = 234/424 (55%), Gaps = 13/424 (3%)
Query: 209 TLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAFGGENKEV 268
T + V P S+I ++ Y K + +S + A + AEE + +VRT+ AFG E E+
Sbjct: 11 TFVLSVVPPVSII-AVIYGRYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEI 69
Query: 269 ERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQY 328
E+Y ++ + RK F G L+ +L + Y L++
Sbjct: 70 EKYASKVDHVMQLARKEA-FARAGFFGATGLSGNLIVLSVLYKGGLLMGS-------AHM 121
Query: 329 PVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPR 388
VG + S L + SI ++ L+EREPK+ + L +
Sbjct: 122 TVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEGVILNEK 181
Query: 389 RVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDP 448
G + ++V F YP+RPEV + + FS+ + G ALVG SG GKSTVL LL RLYDP
Sbjct: 182 SFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDP 241
Query: 449 QAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPE---ATREEIQRV 505
+G++ WLRS +G V QEP+LF +I +NIA G+ + T EEIQRV
Sbjct: 242 ASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRV 301
Query: 506 AEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDP 565
AE+A A FI P G++TV+GE+G LSGGQKQRIAIAR+LL+ P +LLLDEATSALD
Sbjct: 302 AEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDA 361
Query: 566 HSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLM-KAKGFY 624
+E VQ ALDR GRT + ++HRLSTI NA+ + +DQG I E G HE+L+ K G Y
Sbjct: 362 ENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIY 421
Query: 625 HKLV 628
KL+
Sbjct: 422 RKLM 425
Score = 138 bits (333), Expect = 2e-31
Identities = 97/311 (31%), Positives = 153/311 (49%), Gaps = 8/311 (2%)
Query: 886 TLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFL 945
T V +V P+ + ++ + G +K ++++ AT +A E + +++TV++ G E +
Sbjct: 11 TFVLSVVPPVSIIAV-IYGRYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEI 69
Query: 946 QKFQDALKTACVAVAYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEY-KLVLL 1004
+K+ + + R +G + S G +L+ M +L
Sbjct: 70 EKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSF 129
Query: 1005 VNEAIMYGAYMLGQSLVYAPSLNTAKACGARILSIIQRQPKIHNAVGV-KDKKDWVASGN 1063
+ A G + G S Y+ L G R+ +++R+PK+ GV ++K + G
Sbjct: 130 LMYAFWVGISIGGLSSFYS-ELMKGLGAGGRLWELLEREPKLPFNEGVILNEKSF--QGA 186
Query: 1064 FSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFI 1123
++V F YP RP + + L + +G ALVG SG GKST+L L R YDP SG I
Sbjct: 187 LEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTI 246
Query: 1124 ELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYG-DNNRKVTMHEIVAAAKAA 1182
LD DIR L LR ++G V QEP+L S+AENIAYG D+ VT EI A+ A
Sbjct: 247 SLDGHDIRQ-LNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVA 305
Query: 1183 NIHSFIVSLPK 1193
N +FI + P+
Sbjct: 306 NAVAFIRNFPQ 316
Score = 62.9 bits (146), Expect = 7e-09
Identities = 28/56 (50%), Positives = 40/56 (71%)
Query: 1195 VTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWR 1250
V EAL++ GRT + IAHRLST+K+A+++ V+D+GKI E G H EL+S +R
Sbjct: 367 VQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYR 422
>AF216494-1|AAF89993.1| 766|Homo sapiens ATP-binding cassette
protein ABCB9 protein.
Length = 766
Score = 263 bits (645), Expect = 2e-69
Identities = 161/503 (32%), Positives = 258/503 (51%), Gaps = 18/503 (3%)
Query: 140 RIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAV-VSNLVGTSVICL 198
R+R RS++ Q+ S++D + +L S+++ + + + + + + V + N V + + +
Sbjct: 260 RLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVV 319
Query: 199 CTAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTI 258
F L WQL+L P ++ S Y + S + + A AEE + +++T+
Sbjct: 320 FM-FSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTV 378
Query: 259 VAFGGENKEVERYRRLLEPAEEFGRKRG---LFTGLGNGFNWVLTYSLNAIGFSYGTRLV 315
+F E +E E Y R L+ + RK ++ G+G +L ++ + YG LV
Sbjct: 379 RSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLT-LLVVQVSIL--YYGGHLV 435
Query: 316 VNDFDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREP 375
++ T NL + +Y + M + + G +F I+R+P
Sbjct: 436 ISGQMTSGNLIAF---IIYEFVLGDCMESVGSVY-----SGLMQGVGAAEKVFEFIDRQP 487
Query: 376 KIDSLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGK 435
+ + L P + G + E+V F Y +RP +VL+ S + PG+ ALVG SG GK
Sbjct: 488 TM--VHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGK 545
Query: 436 STVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSP 495
S+ + +L+ Y + G V +L + +V QEPVLF +I DNI+ G P
Sbjct: 546 SSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLP 605
Query: 496 EATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLL 555
E + A+ A AH FI L +GY T GE+GA LSGGQKQR+A+AR+L+R P VL+
Sbjct: 606 TVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLI 665
Query: 556 LDEATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHE 615
LDEATSALD SE +Q A+ T + ++HRLST+ +A I+ +D+G +V+QGTH+
Sbjct: 666 LDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQ 725
Query: 616 DLMKAKGFYHKLVTTGNENKEPA 638
L+ G Y KLV +PA
Sbjct: 726 QLLAQGGLYAKLVQRQMLGLQPA 748
Score = 165 bits (402), Expect = 7e-40
Identities = 133/435 (30%), Positives = 205/435 (47%), Gaps = 26/435 (5%)
Query: 781 DLYSVLFVVIAAVA-GISMC--LQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETN 837
D +S V++ +A G S ++ FT ++ RLR+ F SL+ QE FFD+ N
Sbjct: 223 DQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDE--N 280
Query: 838 TVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLMV 897
G + +RL+ DT V I + L+ V + S +W+L+LV + P+++
Sbjct: 281 RTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIM 340
Query: 898 GSIWLEGIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVET----VFLQKFQDALK 953
+ G ++ + +NA+ A+ A E + ++KTV+S E V+L+K Q K
Sbjct: 341 MVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYK 400
Query: 954 -TACVAVAYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEY-KLVLLVNEAIMY 1011
A AY V+G G+ + + S YG LV G+M L+ + +
Sbjct: 401 LNRKEAAAYMY----YVWGSGLTL-LVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVL 455
Query: 1012 GAYMLGQSLVYAPSLNTAKACGARILSIIQRQPK-IHNAVGVKDKKDWVASGNFSMRDVE 1070
G M VY+ L ++ I RQP +H+ D + G +V
Sbjct: 456 GDCMESVGSVYS-GLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLE----GRVDFENVT 510
Query: 1071 FCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDI 1130
F Y TRP +VL+ + + GK ALVG SG GKS+ + + + FY + G + LD + I
Sbjct: 511 FTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPI 570
Query: 1131 RSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVS 1190
SA L R + +V QEPVL RS+ +NI+YG V +V AA+ AN H FI+
Sbjct: 571 -SAYDHKYLHRVISLVSQEPVLFARSITDNISYG--LPTVPFEMVVEAAQKANAHGFIME 627
Query: 1191 LPKAV-TEALEKAAK 1204
L TE EK A+
Sbjct: 628 LQDGYSTETGEKGAQ 642
Score = 56.4 bits (130), Expect = 6e-07
Identities = 25/61 (40%), Positives = 42/61 (68%)
Query: 1195 VTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRMCRG 1254
+ +A+ + T + IAHRLSTV+ A LI V+DKG++V++GTH +L++ G Y ++ +
Sbjct: 681 IQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQR 740
Query: 1255 Q 1255
Q
Sbjct: 741 Q 741
>AB177852-1|BAD66830.1| 796|Homo sapiens KIAA1520 splice variant 1
protein.
Length = 796
Score = 263 bits (645), Expect = 2e-69
Identities = 161/503 (32%), Positives = 258/503 (51%), Gaps = 18/503 (3%)
Query: 140 RIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAV-VSNLVGTSVICL 198
R+R RS++ Q+ S++D + +L S+++ + + + + + + V + N V + + +
Sbjct: 290 RLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVV 349
Query: 199 CTAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTI 258
F L WQL+L P ++ S Y + S + + A AEE + +++T+
Sbjct: 350 FM-FSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTV 408
Query: 259 VAFGGENKEVERYRRLLEPAEEFGRKRG---LFTGLGNGFNWVLTYSLNAIGFSYGTRLV 315
+F E +E E Y R L+ + RK ++ G+G +L ++ + YG LV
Sbjct: 409 RSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLT-LLVVQVSIL--YYGGHLV 465
Query: 316 VNDFDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREP 375
++ T NL + +Y + M + + G +F I+R+P
Sbjct: 466 ISGQMTSGNLIAF---IIYEFVLGDCMESVGSVY-----SGLMQGVGAAEKVFEFIDRQP 517
Query: 376 KIDSLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGK 435
+ + L P + G + E+V F Y +RP +VL+ S + PG+ ALVG SG GK
Sbjct: 518 TM--VHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGK 575
Query: 436 STVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSP 495
S+ + +L+ Y + G V +L + +V QEPVLF +I DNI+ G P
Sbjct: 576 SSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLP 635
Query: 496 EATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLL 555
E + A+ A AH FI L +GY T GE+GA LSGGQKQR+A+AR+L+R P VL+
Sbjct: 636 TVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLI 695
Query: 556 LDEATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHE 615
LDEATSALD SE +Q A+ T + ++HRLST+ +A I+ +D+G +V+QGTH+
Sbjct: 696 LDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQ 755
Query: 616 DLMKAKGFYHKLVTTGNENKEPA 638
L+ G Y KLV +PA
Sbjct: 756 QLLAQGGLYAKLVQRQMLGLQPA 778
Score = 165 bits (402), Expect = 7e-40
Identities = 133/435 (30%), Positives = 205/435 (47%), Gaps = 26/435 (5%)
Query: 781 DLYSVLFVVIAAVA-GISMC--LQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETN 837
D +S V++ +A G S ++ FT ++ RLR+ F SL+ QE FFD+ N
Sbjct: 253 DQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDE--N 310
Query: 838 TVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLMV 897
G + +RL+ DT V I + L+ V + S +W+L+LV + P+++
Sbjct: 311 RTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIM 370
Query: 898 GSIWLEGIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVET----VFLQKFQDALK 953
+ G ++ + +NA+ A+ A E + ++KTV+S E V+L+K Q K
Sbjct: 371 MVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYK 430
Query: 954 -TACVAVAYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEY-KLVLLVNEAIMY 1011
A AY V+G G+ + + S YG LV G+M L+ + +
Sbjct: 431 LNRKEAAAYMY----YVWGSGLTL-LVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVL 485
Query: 1012 GAYMLGQSLVYAPSLNTAKACGARILSIIQRQPK-IHNAVGVKDKKDWVASGNFSMRDVE 1070
G M VY+ L ++ I RQP +H+ D + G +V
Sbjct: 486 GDCMESVGSVYS-GLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLE----GRVDFENVT 540
Query: 1071 FCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDI 1130
F Y TRP +VL+ + + GK ALVG SG GKS+ + + + FY + G + LD + I
Sbjct: 541 FTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPI 600
Query: 1131 RSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVS 1190
SA L R + +V QEPVL RS+ +NI+YG V +V AA+ AN H FI+
Sbjct: 601 -SAYDHKYLHRVISLVSQEPVLFARSITDNISYG--LPTVPFEMVVEAAQKANAHGFIME 657
Query: 1191 LPKAV-TEALEKAAK 1204
L TE EK A+
Sbjct: 658 LQDGYSTETGEKGAQ 672
Score = 56.4 bits (130), Expect = 6e-07
Identities = 25/61 (40%), Positives = 42/61 (68%)
Query: 1195 VTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRMCRG 1254
+ +A+ + T + IAHRLSTV+ A LI V+DKG++V++GTH +L++ G Y ++ +
Sbjct: 711 IQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQR 770
Query: 1255 Q 1255
Q
Sbjct: 771 Q 771
>AB045381-1|BAA97989.2| 766|Homo sapiens TAPL protein.
Length = 766
Score = 263 bits (645), Expect = 2e-69
Identities = 161/503 (32%), Positives = 258/503 (51%), Gaps = 18/503 (3%)
Query: 140 RIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAV-VSNLVGTSVICL 198
R+R RS++ Q+ S++D + +L S+++ + + + + + + V + N V + + +
Sbjct: 260 RLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVV 319
Query: 199 CTAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTI 258
F L WQL+L P ++ S Y + S + + A AEE + +++T+
Sbjct: 320 FM-FSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTV 378
Query: 259 VAFGGENKEVERYRRLLEPAEEFGRKRG---LFTGLGNGFNWVLTYSLNAIGFSYGTRLV 315
+F E +E E Y R L+ + RK ++ G+G +L ++ + YG LV
Sbjct: 379 RSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLT-LLVVQVSIL--YYGGHLV 435
Query: 316 VNDFDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREP 375
++ T NL + +Y + M + + G +F I+R+P
Sbjct: 436 ISGQMTSGNLIAF---IIYEFVLGDCMESVGSVY-----SGLMQGVGAAEKVFEFIDRQP 487
Query: 376 KIDSLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGK 435
+ + L P + G + E+V F Y +RP +VL+ S + PG+ ALVG SG GK
Sbjct: 488 TM--VHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGK 545
Query: 436 STVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSP 495
S+ + +L+ Y + G V +L + +V QEPVLF +I DNI+ G P
Sbjct: 546 SSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLP 605
Query: 496 EATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLL 555
E + A+ A AH FI L +GY T GE+GA LSGGQKQR+A+AR+L+R P VL+
Sbjct: 606 TVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLI 665
Query: 556 LDEATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHE 615
LDEATSALD SE +Q A+ T + ++HRLST+ +A I+ +D+G +V+QGTH+
Sbjct: 666 LDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQ 725
Query: 616 DLMKAKGFYHKLVTTGNENKEPA 638
L+ G Y KLV +PA
Sbjct: 726 QLLAQGGLYAKLVQRQMLGLQPA 748
Score = 165 bits (402), Expect = 7e-40
Identities = 133/435 (30%), Positives = 205/435 (47%), Gaps = 26/435 (5%)
Query: 781 DLYSVLFVVIAAVA-GISMC--LQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETN 837
D +S V++ +A G S ++ FT ++ RLR+ F SL+ QE FFD+ N
Sbjct: 223 DQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDE--N 280
Query: 838 TVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLMV 897
G + +RL+ DT V I + L+ V + S +W+L+LV + P+++
Sbjct: 281 RTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIM 340
Query: 898 GSIWLEGIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVET----VFLQKFQDALK 953
+ G ++ + +NA+ A+ A E + ++KTV+S E V+L+K Q K
Sbjct: 341 MVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYK 400
Query: 954 -TACVAVAYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEY-KLVLLVNEAIMY 1011
A AY V+G G+ + + S YG LV G+M L+ + +
Sbjct: 401 LNRKEAAAYMY----YVWGSGLTL-LVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVL 455
Query: 1012 GAYMLGQSLVYAPSLNTAKACGARILSIIQRQPK-IHNAVGVKDKKDWVASGNFSMRDVE 1070
G M VY+ L ++ I RQP +H+ D + G +V
Sbjct: 456 GDCMESVGSVYS-GLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLE----GRVDFENVT 510
Query: 1071 FCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDI 1130
F Y TRP +VL+ + + GK ALVG SG GKS+ + + + FY + G + LD + I
Sbjct: 511 FTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPI 570
Query: 1131 RSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVS 1190
SA L R + +V QEPVL RS+ +NI+YG V +V AA+ AN H FI+
Sbjct: 571 -SAYDHKYLHRVISLVSQEPVLFARSITDNISYG--LPTVPFEMVVEAAQKANAHGFIME 627
Query: 1191 LPKAV-TEALEKAAK 1204
L TE EK A+
Sbjct: 628 LQDGYSTETGEKGAQ 642
Score = 56.4 bits (130), Expect = 6e-07
Identities = 25/61 (40%), Positives = 42/61 (68%)
Query: 1195 VTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRMCRG 1254
+ +A+ + T + IAHRLSTV+ A LI V+DKG++V++GTH +L++ G Y ++ +
Sbjct: 681 IQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQR 740
Query: 1255 Q 1255
Q
Sbjct: 741 Q 741
>AB040953-1|BAA96044.2| 810|Homo sapiens KIAA1520 protein protein.
Length = 810
Score = 263 bits (645), Expect = 2e-69
Identities = 161/503 (32%), Positives = 258/503 (51%), Gaps = 18/503 (3%)
Query: 140 RIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAV-VSNLVGTSVICL 198
R+R RS++ Q+ S++D + +L S+++ + + + + + + V + N V + + +
Sbjct: 304 RLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVV 363
Query: 199 CTAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTI 258
F L WQL+L P ++ S Y + S + + A AEE + +++T+
Sbjct: 364 FM-FSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTV 422
Query: 259 VAFGGENKEVERYRRLLEPAEEFGRKRG---LFTGLGNGFNWVLTYSLNAIGFSYGTRLV 315
+F E +E E Y R L+ + RK ++ G+G +L ++ + YG LV
Sbjct: 423 RSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLT-LLVVQVSIL--YYGGHLV 479
Query: 316 VNDFDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREP 375
++ T NL + +Y + M + + G +F I+R+P
Sbjct: 480 ISGQMTSGNLIAF---IIYEFVLGDCMESVGSVY-----SGLMQGVGAAEKVFEFIDRQP 531
Query: 376 KIDSLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGK 435
+ + L P + G + E+V F Y +RP +VL+ S + PG+ ALVG SG GK
Sbjct: 532 TM--VHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGK 589
Query: 436 STVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSP 495
S+ + +L+ Y + G V +L + +V QEPVLF +I DNI+ G P
Sbjct: 590 SSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLP 649
Query: 496 EATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLL 555
E + A+ A AH FI L +GY T GE+GA LSGGQKQR+A+AR+L+R P VL+
Sbjct: 650 TVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLI 709
Query: 556 LDEATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHE 615
LDEATSALD SE +Q A+ T + ++HRLST+ +A I+ +D+G +V+QGTH+
Sbjct: 710 LDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQ 769
Query: 616 DLMKAKGFYHKLVTTGNENKEPA 638
L+ G Y KLV +PA
Sbjct: 770 QLLAQGGLYAKLVQRQMLGLQPA 792
Score = 165 bits (402), Expect = 7e-40
Identities = 133/435 (30%), Positives = 205/435 (47%), Gaps = 26/435 (5%)
Query: 781 DLYSVLFVVIAAVA-GISMC--LQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETN 837
D +S V++ +A G S ++ FT ++ RLR+ F SL+ QE FFD+ N
Sbjct: 267 DQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDE--N 324
Query: 838 TVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLMV 897
G + +RL+ DT V I + L+ V + S +W+L+LV + P+++
Sbjct: 325 RTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIM 384
Query: 898 GSIWLEGIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVET----VFLQKFQDALK 953
+ G ++ + +NA+ A+ A E + ++KTV+S E V+L+K Q K
Sbjct: 385 MVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYK 444
Query: 954 -TACVAVAYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEY-KLVLLVNEAIMY 1011
A AY V+G G+ + + S YG LV G+M L+ + +
Sbjct: 445 LNRKEAAAYMY----YVWGSGLTL-LVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVL 499
Query: 1012 GAYMLGQSLVYAPSLNTAKACGARILSIIQRQPK-IHNAVGVKDKKDWVASGNFSMRDVE 1070
G M VY+ L ++ I RQP +H+ D + G +V
Sbjct: 500 GDCMESVGSVYS-GLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLE----GRVDFENVT 554
Query: 1071 FCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDI 1130
F Y TRP +VL+ + + GK ALVG SG GKS+ + + + FY + G + LD + I
Sbjct: 555 FTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPI 614
Query: 1131 RSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVS 1190
SA L R + +V QEPVL RS+ +NI+YG V +V AA+ AN H FI+
Sbjct: 615 -SAYDHKYLHRVISLVSQEPVLFARSITDNISYG--LPTVPFEMVVEAAQKANAHGFIME 671
Query: 1191 LPKAV-TEALEKAAK 1204
L TE EK A+
Sbjct: 672 LQDGYSTETGEKGAQ 686
Score = 56.4 bits (130), Expect = 6e-07
Identities = 25/61 (40%), Positives = 42/61 (68%)
Query: 1195 VTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRMCRG 1254
+ +A+ + T + IAHRLSTV+ A LI V+DKG++V++GTH +L++ G Y ++ +
Sbjct: 725 IQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQR 784
Query: 1255 Q 1255
Q
Sbjct: 785 Q 785
>BC141836-1|AAI41837.1| 693|Homo sapiens Unknown (protein for
MGC:165100) protein.
Length = 693
Score = 263 bits (644), Expect = 3e-69
Identities = 180/498 (36%), Positives = 260/498 (52%), Gaps = 23/498 (4%)
Query: 100 ALIDDAKAMAIGMFISIGVSLVFCVLSFSLISWSALRQITRIRTLFLRSVLRQDMSWYDT 159
+ + +++ ++ + I GV + L+S R +R S+LRQD++++D
Sbjct: 169 SFMTESQNLSTHLLILYGVQGLLTFGYLVLLSHVGERMAVDMRRALFSSLLRQDITFFDA 228
Query: 160 DSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVI--CLCTAFPLGWQLTLACAAVMP 217
+ L S+++ ++ K KL + L + + CL + L +LTL P
Sbjct: 229 NKTGQLVSRLTTDVQEFKSSF--KLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATP 286
Query: 218 FSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAFGGENKEVERYRRLLEP 277
+ + + K S + E + A A+E L +VRT+ AF E +E ERY LE
Sbjct: 287 ALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEA 346
Query: 278 ----AEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSY-GTRLVVNDFDTDSNLRQYPVGA 332
AEE GR LF GL N + ++ +G + G LV T +L + V A
Sbjct: 347 CRCRAEELGRGIALFQGLSN-----IAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLV-A 400
Query: 333 VYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPRRVVG 392
++ S MA S+ F + G +F + P I + ++ G
Sbjct: 401 SQTVQRS--MANLSVLFGQV-VRGLSAGAR----VFEYMALNPCIPLSGGCCVPKEQLRG 453
Query: 393 DILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGS 452
+ ++V F YP RP +VLK F++ + PG+ VALVG SG GK+TV LL+R YDP AG
Sbjct: 454 SVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGV 513
Query: 453 VXXXXXXXXXXXXSWLRSSL-GVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYA 511
V SWLR + G + QEPVLF TI +NI G EA+ EE+ A A A
Sbjct: 514 VMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIMENIRFGKLEASDEEVYTAAREANA 573
Query: 512 HDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV 571
H+FI+ P GY+TV+GERG +LSGGQKQR+AIAR+L+++P VL+LDEATSALD SER V
Sbjct: 574 HEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERVV 633
Query: 572 QAALDRASVGRTTITVSH 589
Q ALDRAS GRT + +H
Sbjct: 634 QEALDRASAGRTVLAGTH 651
Score = 158 bits (383), Expect = 1e-37
Identities = 127/418 (30%), Positives = 208/418 (49%), Gaps = 21/418 (5%)
Query: 784 SVLFVVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAIC 843
S +++ V G+ + G +M +R F+SLL+Q+I FFD N G +
Sbjct: 178 STHLLILYGVQGLLTFGYLVLLSHVGERMAVDMRRALFSSLLRQDITFFD--ANKTGQLV 235
Query: 844 ARLSGDTAEVQGATGLRIGLILQGISSV--VVGFLLAISY-NWKLTLVATVFLPLMVGSI 900
+RL+ D E + + L +I QG+ S V G L+++S + +LTL+ V P ++G
Sbjct: 236 SRLTTDVQEFKSSFKL---VISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMGVG 292
Query: 901 WLEGIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVA 960
L G +K + + A +A EA+ +++TV++ +E +++ L+
Sbjct: 293 TLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAE 352
Query: 961 YKTRWRGLVYGLGVYIPFMAYCSATVY-GAVLVAYGEM---EYKLVLLVNEAIMYGAYML 1016
R L GL I F T++ G LVA ++ + L+ ++ + M
Sbjct: 353 ELGRGIALFQGLS-NIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRS--MA 409
Query: 1017 GQSLVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTR 1076
S+++ + A GAR+ + P I + G K+ + G+ + ++V F YP R
Sbjct: 410 NLSVLFGQVVRGLSA-GARVFEYMALNPCIPLSGGCCVPKEQLR-GSVTFQNVCFSYPCR 467
Query: 1077 PSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTI 1136
P VLK L + GK +ALVG SG GK+T+ L +RFYDP +G + LD RD+R+ L
Sbjct: 468 PGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRT-LDP 526
Query: 1137 PRLRRQ-LGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPK 1193
LR Q +G + QEPVL ++ ENI +G + + E+ AA+ AN H FI S P+
Sbjct: 527 SWLRGQVVGFISQEPVLFGTTIMENIRFG--KLEASDEEVYTAAREANAHEFITSFPE 582
>BC064384-1|AAH64384.1| 769|Homo sapiens ABCB9 protein protein.
Length = 769
Score = 260 bits (637), Expect = 2e-68
Identities = 162/506 (32%), Positives = 259/506 (51%), Gaps = 21/506 (4%)
Query: 140 RIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAV-VSNLVGTSVICL 198
R+R RS++ Q+ S++D + +L S+++ + + + + + + V + N V + + +
Sbjct: 260 RLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVV 319
Query: 199 CTAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTI 258
F L WQL+L P ++ S Y + S + + A AEE + +++T+
Sbjct: 320 FM-FSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTV 378
Query: 259 VAFGGENKEVERYRRLLEPAEEFGRKRG---LFTGLGNGFNWVLTYSLNAIGFSYGTRLV 315
+F E +E E Y R L+ + RK ++ G+G +L ++ + YG LV
Sbjct: 379 RSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLT-LLVVQVSIL--YYGGHLV 435
Query: 316 VNDFDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREP 375
++ T NL + +Y + M + + G +F I+R+P
Sbjct: 436 ISGQMTSGNLIAF---IIYEFVLGDCMESVGSVY-----SGLMQGVGAAEKVFEFIDRQP 487
Query: 376 KIDSLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGK 435
+ + L P + G + E+V F Y +RP +VL+ S + PG+ ALVG SG GK
Sbjct: 488 TM--VHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGK 545
Query: 436 STVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSP 495
S+ + +L+ Y + G V +L + +V QEPVLF +I DNI+ G P
Sbjct: 546 SSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLP 605
Query: 496 EATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLL 555
E + A+ A AH FI L +GY T GE+GA LSGGQKQR+A+AR+L+R P VL+
Sbjct: 606 TVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLI 665
Query: 556 LDEATSALDPHSE---RQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQG 612
LDEATSALD SE Q+Q A+ T + ++HRLST+ +A I+ +D+G +V+QG
Sbjct: 666 LDEATSALDAESEYLSPQIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQG 725
Query: 613 THEDLMKAKGFYHKLVTTGNENKEPA 638
TH+ L+ G Y KLV +PA
Sbjct: 726 THQQLLAQGGLYAKLVQRQMLGLQPA 751
Score = 165 bits (402), Expect = 7e-40
Identities = 133/435 (30%), Positives = 205/435 (47%), Gaps = 26/435 (5%)
Query: 781 DLYSVLFVVIAAVA-GISMC--LQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETN 837
D +S V++ +A G S ++ FT ++ RLR+ F SL+ QE FFD+ N
Sbjct: 223 DQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDE--N 280
Query: 838 TVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLMV 897
G + +RL+ DT V I + L+ V + S +W+L+LV + P+++
Sbjct: 281 RTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIM 340
Query: 898 GSIWLEGIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVET----VFLQKFQDALK 953
+ G ++ + +NA+ A+ A E + ++KTV+S E V+L+K Q K
Sbjct: 341 MVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYK 400
Query: 954 -TACVAVAYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEY-KLVLLVNEAIMY 1011
A AY V+G G+ + + S YG LV G+M L+ + +
Sbjct: 401 LNRKEAAAYMY----YVWGSGLTL-LVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVL 455
Query: 1012 GAYMLGQSLVYAPSLNTAKACGARILSIIQRQPK-IHNAVGVKDKKDWVASGNFSMRDVE 1070
G M VY+ L ++ I RQP +H+ D + G +V
Sbjct: 456 GDCMESVGSVYS-GLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLE----GRVDFENVT 510
Query: 1071 FCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDI 1130
F Y TRP +VL+ + + GK ALVG SG GKS+ + + + FY + G + LD + I
Sbjct: 511 FTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPI 570
Query: 1131 RSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVS 1190
SA L R + +V QEPVL RS+ +NI+YG V +V AA+ AN H FI+
Sbjct: 571 -SAYDHKYLHRVISLVSQEPVLFARSITDNISYG--LPTVPFEMVVEAAQKANAHGFIME 627
Query: 1191 LPKAV-TEALEKAAK 1204
L TE EK A+
Sbjct: 628 LQDGYSTETGEKGAQ 642
Score = 56.8 bits (131), Expect = 5e-07
Identities = 26/65 (40%), Positives = 43/65 (66%)
Query: 1191 LPKAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWR 1250
L + +A+ + T + IAHRLSTV+ A LI V+DKG++V++GTH +L++ G Y +
Sbjct: 680 LSPQIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAK 739
Query: 1251 MCRGQ 1255
+ + Q
Sbjct: 740 LVQRQ 744
>AC006154-1|AAD05023.1| 407|Homo sapiens unknown protein.
Length = 407
Score = 255 bits (624), Expect = 8e-67
Identities = 140/430 (32%), Positives = 236/430 (54%), Gaps = 24/430 (5%)
Query: 24 FRYGNCLELLATALGVVFGMISGAGVCCNLLQIGELSTAFVERT-KYHDRLSSYLPLTAT 82
FRY + + L +LG + + G+G+ ++ GE++ FV+ + ++ L L
Sbjct: 1 FRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSL--- 57
Query: 83 FGGGKRLVNATHEQNMEALIDDAKAMAIGMFISIGVSLVFCVLSFSLISWSALRQITRIR 142
GK L E+ M + G+ ++ + + F L +A RQI +IR
Sbjct: 58 LNPGKIL-----EEEMTRYAYYYSGLGAGVLVAAYIQVSFWTL-------AAGRQIRKIR 105
Query: 143 TLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAF 202
F ++LRQ++ W+D + L +++++++ I EG+G+K+ + V T F
Sbjct: 106 QKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGF 165
Query: 203 PLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAFG 262
GW+LTL A+ P +++ + + S +E+ +Y+ AG AEE L ++RT++AFG
Sbjct: 166 IRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFG 225
Query: 263 GENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTD 322
G+NKE+ERY++ LE A+E G K+ + + G ++L Y+ A+ F YG+ LV++
Sbjct: 226 GQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVIS----- 280
Query: 323 SNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQ 382
++Y +G ++ FS+ + S+ P ++ F IF +I+ PKIDS +
Sbjct: 281 ---KEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSE 337
Query: 383 KGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLL 442
+G P + G++ DV F YPSR VK+LKG ++ V+ G+ VALVGSSGCGKST +QL+
Sbjct: 338 RGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLI 397
Query: 443 QRLYDPQAGS 452
QRLYDP G+
Sbjct: 398 QRLYDPDEGT 407
Score = 184 bits (447), Expect = 2e-45
Identities = 108/341 (31%), Positives = 183/341 (53%), Gaps = 7/341 (2%)
Query: 783 YSVLFVVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAI 842
Y+ + + A ++ +Q + +T A + ++R ++F ++L+QEIG+FD N +
Sbjct: 71 YAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFD--INDTTEL 128
Query: 843 CARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLM--VGSI 900
RL+ D +++ G ++G+ Q +++ GF++ WKLTLV P++ ++
Sbjct: 129 NTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAV 188
Query: 901 WLEGIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVA 960
W + I+S + E A A A+A EA+ +I+TV + G + L+++Q L+ A
Sbjct: 189 WAK-ILSAFSD-KELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGI 246
Query: 961 YKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSL 1020
K + G+ + + +Y A YG+ LV E + V +I+ GA+ +GQ+
Sbjct: 247 KKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAA 306
Query: 1021 VYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQR 1080
+ A+ I II PKI + K D + GN DV F YP+R + +
Sbjct: 307 PCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSI-KGNLEFNDVHFSYPSRANVK 365
Query: 1081 VLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSG 1121
+LKG++LK+++G+T+ALVGSSGCGKST +QL QR YDPD G
Sbjct: 366 ILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEG 406
>AK074738-1|BAC11171.1| 472|Homo sapiens protein ( Homo sapiens
cDNA FLJ90257 fis, clone NT2RM4000444, weakly similar to
ANTIGEN PEPTIDE TRANSPORTER 1. ).
Length = 472
Score = 248 bits (607), Expect = 1e-64
Identities = 149/440 (33%), Positives = 225/440 (51%), Gaps = 16/440 (3%)
Query: 202 FPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAF 261
F L WQL+L P ++ S Y + S + + A AEE + +++T+ +F
Sbjct: 28 FSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSF 87
Query: 262 GGENKEVERYRRLLEPAEEFGRKRG---LFTGLGNGFNWVLTYSLNAIGFSYGTRLVVND 318
E +E E Y R L+ + RK ++ G+G +L ++ + YG LV++
Sbjct: 88 ANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLT-LLVVQVSIL--YYGGHLVISG 144
Query: 319 FDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKID 378
T NL + +Y + M + + G +F I+R+P +
Sbjct: 145 QMTSGNLIAF---IIYEFVLGDCMESVGSVY-----SGLMQGVGAAEKVFEFIDRQPTM- 195
Query: 379 SLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTV 438
+ L P + G + E+V F Y +RP +VL+ S + PG+ ALVG SG GKS+
Sbjct: 196 -VHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSC 254
Query: 439 LQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEAT 498
+ +L+ Y + G V +L + +V QEPVLF +I DNI+ G P
Sbjct: 255 VNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVP 314
Query: 499 REEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 558
E + A+ A AH FI L +GY T GE+GA LSGGQKQR+A+AR+L+R P VL+LDE
Sbjct: 315 FEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDE 374
Query: 559 ATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLM 618
ATSALD SE +Q A+ T + ++HRLST+ +A I+ +D+G +V+QGTH+ L+
Sbjct: 375 ATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLL 434
Query: 619 KAKGFYHKLVTTGNENKEPA 638
G Y KLV +PA
Sbjct: 435 AQGGLYAKLVQRQMLGLQPA 454
Score = 132 bits (318), Expect = 1e-29
Identities = 107/352 (30%), Positives = 165/352 (46%), Gaps = 21/352 (5%)
Query: 861 IGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMES 920
I + L+ V + S +W+L+LV + P+++ + G ++ + +NA+
Sbjct: 10 INVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALAR 69
Query: 921 ATAIATEAVVSIKTVQSLGVET----VFLQKFQDALK-TACVAVAYKTRWRGLVYGLGVY 975
A+ A E + ++KTV+S E V+L+K Q K A AY V+G G+
Sbjct: 70 ASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMY----YVWGSGLT 125
Query: 976 IPFMAYCSATVYGAVLVAYGEMEY-KLVLLVNEAIMYGAYMLGQSLVYAPSLNTAKACGA 1034
+ + S YG LV G+M L+ + + G M VY+ L
Sbjct: 126 L-LVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYS-GLMQGVGAAE 183
Query: 1035 RILSIIQRQPK-IHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGK 1093
++ I RQP +H+ D + G +V F Y TRP +VL+ + + GK
Sbjct: 184 KVFEFIDRQPTMVHDGSLAPDHLE----GRVDFENVTFTYRTRPHTQVLQNVSFSLSPGK 239
Query: 1094 TIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLL 1153
ALVG SG GKS+ + + + FY + G + LD + I SA L R + +V QEPVL
Sbjct: 240 VTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPI-SAYDHKYLHRVISLVSQEPVLF 298
Query: 1154 DRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAV-TEALEKAAK 1204
RS+ +NI+YG V +V AA+ AN H FI+ L TE EK A+
Sbjct: 299 ARSITDNISYG--LPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQ 348
Score = 56.4 bits (130), Expect = 6e-07
Identities = 25/61 (40%), Positives = 42/61 (68%)
Query: 1195 VTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRMCRG 1254
+ +A+ + T + IAHRLSTV+ A LI V+DKG++V++GTH +L++ G Y ++ +
Sbjct: 387 IQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQR 446
Query: 1255 Q 1255
Q
Sbjct: 447 Q 447
>AY523970-1|AAS55411.1| 748|Homo sapiens TAP1 protein.
Length = 748
Score = 248 bits (606), Expect = 1e-64
Identities = 153/488 (31%), Positives = 258/488 (52%), Gaps = 21/488 (4%)
Query: 148 SVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPLGW- 206
+VLRQ+ ++ + N+ S+++E+ ++ + + E L++ + V LC + W
Sbjct: 267 AVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSL---FLWYLVRGLCLLGIMLWG 323
Query: 207 --QLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAFGGE 264
LT+ +P + + + ++ ES + + + A E+L ++ T+ +F E
Sbjct: 324 SVSLTMVTLVTLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEVLSAMPTVRSFANE 383
Query: 265 NKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSY-GTRLVVNDFDTDS 323
E +++R L+ + +K + + N + ++ L +G Y G +LV + +
Sbjct: 384 EGEAQKFREKLQEIKTLNQKEAVAYAV-NSWTTSISGMLLKVGILYIGGQLVTSGAVSSG 442
Query: 324 NLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQK 383
NL + +Y + F+ A + + P ++ IF ++R P+
Sbjct: 443 NLVTF---VLYQMQFT--QAVEVLLSIYPRVQ---KAVGSSEKIFEYLDRTPRCPPSGL- 493
Query: 384 GLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQ 443
LTP + G + +DV F YP+RP++ VL+G + ++PGE ALVG +G GKSTV LLQ
Sbjct: 494 -LTPLHLEGLVQFQDVSFAYPNRPDILVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQ 552
Query: 444 RLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIG-SPEATREEI 502
LY P G + +L + VGQEP +F ++ +NIA G + + T EEI
Sbjct: 553 NLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEI 612
Query: 503 QRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSA 562
A + AH FIS LP GYDT +GE G+ LSGGQ+Q +A+AR+L+R+P VL+LD+ATSA
Sbjct: 613 TAAAVKSGAHSFISGLPQGYDTEVGEAGSQLSGGQRQAVALARALIRKPCVLILDDATSA 672
Query: 563 LDPHSERQVQAALDRA--SVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKA 620
LD +S+ QV+ L + R+ + ++ LS + AD I+ ++ G I E GTH+ LM+
Sbjct: 673 LDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEK 732
Query: 621 KGFYHKLV 628
KG Y +V
Sbjct: 733 KGCYWAMV 740
Score = 134 bits (323), Expect = 2e-30
Identities = 115/388 (29%), Positives = 183/388 (47%), Gaps = 23/388 (5%)
Query: 814 TRLRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGI--SSV 871
+ L+ + F ++L+QE FF + N G I +R++ DT+ + + + L L +
Sbjct: 258 SHLQGEVFGAVLRQETEFFQQ--NQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLC 315
Query: 872 VVGFLLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVS 931
++G +L S + LT+V V LPL+ G Q ++ R ++ ++ +A E + +
Sbjct: 316 LLGIMLWGSVS--LTMVTLVTLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEVLSA 373
Query: 932 IKTVQSLGVETVFLQKFQDALKTACV-----AVAYKTR-WRGLVYGLGVYIPFMAYCSAT 985
+ TV+S E QKF++ L+ AVAY W + G+ + + + Y
Sbjct: 374 MPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGIL-YIGGQ 432
Query: 986 VYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYAPSLNTAKACGARILSIIQRQPK 1045
+ + V+ G LV V + + + +Y P + A +I + R P+
Sbjct: 433 LVTSGAVSSGN----LVTFVLYQMQFTQAVEVLLSIY-PRVQKAVGSSEKIFEYLDRTPR 487
Query: 1046 IHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGK 1105
+ G+ G +DV F YP RP VL+G+ + G+ ALVG +G GK
Sbjct: 488 CPPS-GLLTPLH--LEGLVQFQDVSFAYPNRPDILVLQGLTFTLRPGEVTALVGPNGSGK 544
Query: 1106 STILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGD 1165
ST+ L Q Y P G + LD + + L RQ+ V QEP + RSL ENIAYG
Sbjct: 545 STVAALLQNLYQPTGGQLLLDGKPL-PQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYG- 602
Query: 1166 NNRKVTMHEIVAAAKAANIHSFIVSLPK 1193
+K TM EI AAA + HSFI LP+
Sbjct: 603 LTQKPTMEEITAAAVKSGAHSFISGLPQ 630
Score = 42.7 bits (96), Expect = 0.008
Identities = 20/46 (43%), Positives = 27/46 (58%)
Query: 1206 RTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRM 1251
R+ + I LS V+ AD I ++ G I E GTH +L+ KG YW M
Sbjct: 694 RSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAM 739
>L21206-1|AAC12904.1| 748|Homo sapiens peptide transporter protein.
Length = 748
Score = 246 bits (603), Expect = 3e-64
Identities = 154/488 (31%), Positives = 257/488 (52%), Gaps = 21/488 (4%)
Query: 148 SVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPLGW- 206
+VLRQ+ ++ + N+ S+++E+ ++ + + E L++ + V LC + W
Sbjct: 267 AVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSL---FLWYLVRGLCLLGIMLWG 323
Query: 207 --QLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAFGGE 264
LT+ +P + + + ++ ES + + + A E L ++ T+ +F E
Sbjct: 324 SVSLTMVTLVTLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANE 383
Query: 265 NKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSY-GTRLVVNDFDTDS 323
E +++R L+ + +K + + N + ++ L +G Y G +LV + +
Sbjct: 384 EGEAQKFREKLQEIKTLNQKEAVAYAV-NSWTTSISGMLLKVGILYIGGQLVTSGAVSSG 442
Query: 324 NLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQK 383
NL + +Y + F+ A + + P ++ IF ++R P+
Sbjct: 443 NLVTF---VLYQMQFT--QAVEVLLSIYPRVQ---KAVGSSEKIFEYLDRTPRCPPSGL- 493
Query: 384 GLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQ 443
LTP + G + +DV F YP+RP+V VL+G + ++PGE ALVG +G GKSTV LLQ
Sbjct: 494 -LTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQ 552
Query: 444 RLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIG-SPEATREEI 502
LY P G + +L + VGQEP +F ++ +NIA G + + T EEI
Sbjct: 553 NLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEI 612
Query: 503 QRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSA 562
A + AH FIS LP GYDT +GE G+ LSGGQ+Q +A+AR+L+R+P VL+LD+ATSA
Sbjct: 613 TAAAVKSGAHSFISGLPQGYDTEVGEAGSQLSGGQRQAVALARALIRKPCVLILDDATSA 672
Query: 563 LDPHSERQVQAALDRA--SVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKA 620
LD +S+ QV+ L + R+ + ++ LS + AD I+ ++ G I E GTH+ LM+
Sbjct: 673 LDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEK 732
Query: 621 KGFYHKLV 628
KG Y +V
Sbjct: 733 KGCYWAMV 740
Score = 136 bits (328), Expect = 6e-31
Identities = 116/388 (29%), Positives = 184/388 (47%), Gaps = 23/388 (5%)
Query: 814 TRLRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGI--SSV 871
+ L+ + F ++L+QE FF + N G I +R++ DT+ + + + L L +
Sbjct: 258 SHLQGEVFGAVLRQETEFFQQ--NQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLC 315
Query: 872 VVGFLLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVS 931
++G +L S + LT+V V LPL+ G Q ++ R ++ ++ +A EA+ +
Sbjct: 316 LLGIMLWGSVS--LTMVTLVTLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSA 373
Query: 932 IKTVQSLGVETVFLQKFQDALKTACV-----AVAYKTR-WRGLVYGLGVYIPFMAYCSAT 985
+ TV+S E QKF++ L+ AVAY W + G+ + + + Y
Sbjct: 374 MPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGIL-YIGGQ 432
Query: 986 VYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYAPSLNTAKACGARILSIIQRQPK 1045
+ + V+ G LV V + + + +Y P + A +I + R P+
Sbjct: 433 LVTSGAVSSGN----LVTFVLYQMQFTQAVEVLLSIY-PRVQKAVGSSEKIFEYLDRTPR 487
Query: 1046 IHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGK 1105
+ G+ G +DV F YP RP VL+G+ + G+ ALVG +G GK
Sbjct: 488 CPPS-GLLTPLH--LEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGK 544
Query: 1106 STILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGD 1165
ST+ L Q Y P G + LD + + L RQ+ V QEP + RSL ENIAYG
Sbjct: 545 STVAALLQNLYQPTGGQLLLDGKPL-PQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYG- 602
Query: 1166 NNRKVTMHEIVAAAKAANIHSFIVSLPK 1193
+K TM EI AAA + HSFI LP+
Sbjct: 603 LTQKPTMEEITAAAVKSGAHSFISGLPQ 630
Score = 42.7 bits (96), Expect = 0.008
Identities = 20/46 (43%), Positives = 27/46 (58%)
Query: 1206 RTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRM 1251
R+ + I LS V+ AD I ++ G I E GTH +L+ KG YW M
Sbjct: 694 RSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAM 739
>L21205-1|AAC12903.1| 748|Homo sapiens peptide transporter protein.
Length = 748
Score = 246 bits (603), Expect = 3e-64
Identities = 154/488 (31%), Positives = 257/488 (52%), Gaps = 21/488 (4%)
Query: 148 SVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPLGW- 206
+VLRQ+ ++ + N+ S+++E+ ++ + + E L++ + V LC + W
Sbjct: 267 AVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSL---FLWYLVRGLCLLGIMLWG 323
Query: 207 --QLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAFGGE 264
LT+ +P + + + ++ ES + + + A E L ++ T+ +F E
Sbjct: 324 SVSLTMVTLVTLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANE 383
Query: 265 NKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSY-GTRLVVNDFDTDS 323
E +++R L+ + +K + + N + ++ L +G Y G +LV + +
Sbjct: 384 EGEAQKFREKLQEIKTLNQKEAVAYAV-NSWTTSISGMLLKVGILYIGGQLVTSGAVSSG 442
Query: 324 NLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQK 383
NL + +Y + F+ A + + P ++ IF ++R P+
Sbjct: 443 NLVTF---VLYQMQFT--QAVEVLLSIYPRVQ---KAVGSSEKIFEYLDRTPRCPPSGL- 493
Query: 384 GLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQ 443
LTP + G + +DV F YP+RP+V VL+G + ++PGE ALVG +G GKSTV LLQ
Sbjct: 494 -LTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQ 552
Query: 444 RLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIG-SPEATREEI 502
LY P G + +L + VGQEP +F ++ +NIA G + + T EEI
Sbjct: 553 NLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEI 612
Query: 503 QRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSA 562
A + AH FIS LP GYDT +GE G+ LSGGQ+Q +A+AR+L+R+P VL+LD+ATSA
Sbjct: 613 TAAAVKSGAHSFISGLPQGYDTEVGEAGSQLSGGQRQAVALARALIRKPCVLILDDATSA 672
Query: 563 LDPHSERQVQAALDRA--SVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKA 620
LD +S+ QV+ L + R+ + ++ LS + AD I+ ++ G I E GTH+ LM+
Sbjct: 673 LDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEK 732
Query: 621 KGFYHKLV 628
KG Y +V
Sbjct: 733 KGCYWAMV 740
Score = 136 bits (328), Expect = 6e-31
Identities = 116/388 (29%), Positives = 184/388 (47%), Gaps = 23/388 (5%)
Query: 814 TRLRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGI--SSV 871
+ L+ + F ++L+QE FF + N G I +R++ DT+ + + + L L +
Sbjct: 258 SHLQGEVFGAVLRQETEFFQQ--NQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLC 315
Query: 872 VVGFLLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVS 931
++G +L S + LT+V V LPL+ G Q ++ R ++ ++ +A EA+ +
Sbjct: 316 LLGIMLWGSVS--LTMVTLVTLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSA 373
Query: 932 IKTVQSLGVETVFLQKFQDALKTACV-----AVAYKTR-WRGLVYGLGVYIPFMAYCSAT 985
+ TV+S E QKF++ L+ AVAY W + G+ + + + Y
Sbjct: 374 MPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGIL-YIGGQ 432
Query: 986 VYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYAPSLNTAKACGARILSIIQRQPK 1045
+ + V+ G LV V + + + +Y P + A +I + R P+
Sbjct: 433 LVTSGAVSSGN----LVTFVLYQMQFTQAVEVLLSIY-PRVQKAVGSSEKIFEYLDRTPR 487
Query: 1046 IHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGK 1105
+ G+ G +DV F YP RP VL+G+ + G+ ALVG +G GK
Sbjct: 488 CPPS-GLLTPLH--LEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGK 544
Query: 1106 STILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGD 1165
ST+ L Q Y P G + LD + + L RQ+ V QEP + RSL ENIAYG
Sbjct: 545 STVAALLQNLYQPTGGQLLLDGKPL-PQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYG- 602
Query: 1166 NNRKVTMHEIVAAAKAANIHSFIVSLPK 1193
+K TM EI AAA + HSFI LP+
Sbjct: 603 LTQKPTMEEITAAAVKSGAHSFISGLPQ 630
Score = 42.7 bits (96), Expect = 0.008
Identities = 20/46 (43%), Positives = 27/46 (58%)
Query: 1206 RTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRM 1251
R+ + I LS V+ AD I ++ G I E GTH +L+ KG YW M
Sbjct: 694 RSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAM 739
>AY523971-1|AAS55412.1| 748|Homo sapiens TAP1 protein.
Length = 748
Score = 246 bits (603), Expect = 3e-64
Identities = 154/488 (31%), Positives = 257/488 (52%), Gaps = 21/488 (4%)
Query: 148 SVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPLGW- 206
+VLRQ+ ++ + N+ S+++E+ ++ + + E L++ + V LC + W
Sbjct: 267 AVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSL---FLWYLVRGLCLLGIMLWG 323
Query: 207 --QLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAFGGE 264
LT+ +P + + + ++ ES + + + A E L ++ T+ +F E
Sbjct: 324 SVSLTMVTLVTLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANE 383
Query: 265 NKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSY-GTRLVVNDFDTDS 323
E +++R L+ + +K + + N + ++ L +G Y G +LV + +
Sbjct: 384 EGEAQKFREKLQEIKTLNQKEAVAYAV-NSWTTSISGMLLKVGILYIGGQLVTSGAVSSG 442
Query: 324 NLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQK 383
NL + +Y + F+ A + + P ++ IF ++R P+
Sbjct: 443 NLVTF---VLYQMQFT--QAVEVLLSIYPRVQ---KAVGSSEKIFEYLDRTPRCPPSGL- 493
Query: 384 GLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQ 443
LTP + G + +DV F YP+RP+V VL+G + ++PGE ALVG +G GKSTV LLQ
Sbjct: 494 -LTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQ 552
Query: 444 RLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIG-SPEATREEI 502
LY P G + +L + VGQEP +F ++ +NIA G + + T EEI
Sbjct: 553 NLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEI 612
Query: 503 QRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSA 562
A + AH FIS LP GYDT +GE G+ LSGGQ+Q +A+AR+L+R+P VL+LD+ATSA
Sbjct: 613 TAAAVKSGAHSFISGLPQGYDTEVGEAGSQLSGGQRQAVALARALIRKPCVLILDDATSA 672
Query: 563 LDPHSERQVQAALDRA--SVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKA 620
LD +S+ QV+ L + R+ + ++ LS + AD I+ ++ G I E GTH+ LM+
Sbjct: 673 LDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEK 732
Query: 621 KGFYHKLV 628
KG Y +V
Sbjct: 733 KGCYWAMV 740
Score = 136 bits (328), Expect = 6e-31
Identities = 116/388 (29%), Positives = 184/388 (47%), Gaps = 23/388 (5%)
Query: 814 TRLRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGI--SSV 871
+ L+ + F ++L+QE FF + N G I +R++ DT+ + + + L L +
Sbjct: 258 SHLQGEVFGAVLRQETEFFQQ--NQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLC 315
Query: 872 VVGFLLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVS 931
++G +L S + LT+V V LPL+ G Q ++ R ++ ++ +A EA+ +
Sbjct: 316 LLGIMLWGSVS--LTMVTLVTLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSA 373
Query: 932 IKTVQSLGVETVFLQKFQDALKTACV-----AVAYKTR-WRGLVYGLGVYIPFMAYCSAT 985
+ TV+S E QKF++ L+ AVAY W + G+ + + + Y
Sbjct: 374 MPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGIL-YIGGQ 432
Query: 986 VYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYAPSLNTAKACGARILSIIQRQPK 1045
+ + V+ G LV V + + + +Y P + A +I + R P+
Sbjct: 433 LVTSGAVSSGN----LVTFVLYQMQFTQAVEVLLSIY-PRVQKAVGSSEKIFEYLDRTPR 487
Query: 1046 IHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGK 1105
+ G+ G +DV F YP RP VL+G+ + G+ ALVG +G GK
Sbjct: 488 CPPS-GLLTPLH--LEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGK 544
Query: 1106 STILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGD 1165
ST+ L Q Y P G + LD + + L RQ+ V QEP + RSL ENIAYG
Sbjct: 545 STVAALLQNLYQPTGGQLLLDGKPL-PQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYG- 602
Query: 1166 NNRKVTMHEIVAAAKAANIHSFIVSLPK 1193
+K TM EI AAA + HSFI LP+
Sbjct: 603 LTQKPTMEEITAAAVKSGAHSFISGLPQ 630
Score = 42.7 bits (96), Expect = 0.008
Identities = 20/46 (43%), Positives = 27/46 (58%)
Query: 1206 RTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRM 1251
R+ + I LS V+ AD I ++ G I E GTH +L+ KG YW M
Sbjct: 694 RSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAM 739
>L21207-1|AAC12905.1| 748|Homo sapiens peptide transporter protein.
Length = 748
Score = 246 bits (601), Expect = 5e-64
Identities = 154/488 (31%), Positives = 257/488 (52%), Gaps = 21/488 (4%)
Query: 148 SVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPLGW- 206
+VLRQ+ ++ + N+ S+++E+ ++ + + E L++ + V LC + W
Sbjct: 267 AVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSL---FLWYLVRGLCLLGIMLWG 323
Query: 207 --QLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAFGGE 264
LT+ +P + + + ++ ES + + + A E L ++ T+ +F E
Sbjct: 324 SVSLTMVTLVTLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANE 383
Query: 265 NKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSY-GTRLVVNDFDTDS 323
E +++R L+ + +K + + N + ++ L +G Y G +LV + +
Sbjct: 384 EGEAQKFREKLQEIKTLNQKEAVAYAV-NSWTTSISGMLLKVGILYIGGQLVTSGAVSSG 442
Query: 324 NLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQK 383
NL + +Y + F+ A + + P ++ IF ++R P+
Sbjct: 443 NLVTF---VLYQMQFT--QALEVLLSIYPRVQ---KAVGSSEKIFEYLDRTPRCPPSGL- 493
Query: 384 GLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQ 443
LTP + G + +DV F YP+RP+V VL+G + ++PGE ALVG +G GKSTV LLQ
Sbjct: 494 -LTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQ 552
Query: 444 RLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIG-SPEATREEI 502
LY P G + +L + VGQEP +F ++ +NIA G + + T EEI
Sbjct: 553 NLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEI 612
Query: 503 QRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSA 562
A + AH FIS LP GYDT +GE G+ LSGGQ+Q +A+AR+L+R+P VL+LD+ATSA
Sbjct: 613 TAAAVKSGAHSFISGLPQGYDTEVGEAGSQLSGGQQQAVALARALIRKPCVLILDDATSA 672
Query: 563 LDPHSERQVQAALDRA--SVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKA 620
LD +S+ QV+ L + R+ + ++ LS + AD I+ ++ G I E GTH+ LM+
Sbjct: 673 LDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEK 732
Query: 621 KGFYHKLV 628
KG Y +V
Sbjct: 733 KGCYWAMV 740
Score = 136 bits (329), Expect = 5e-31
Identities = 116/388 (29%), Positives = 184/388 (47%), Gaps = 23/388 (5%)
Query: 814 TRLRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGI--SSV 871
+ L+ + F ++L+QE FF + N G I +R++ DT+ + + + L L +
Sbjct: 258 SHLQGEVFGAVLRQETEFFQQ--NQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLC 315
Query: 872 VVGFLLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVS 931
++G +L S + LT+V V LPL+ G Q ++ R ++ ++ +A EA+ +
Sbjct: 316 LLGIMLWGSVS--LTMVTLVTLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSA 373
Query: 932 IKTVQSLGVETVFLQKFQDALKTACV-----AVAYKTR-WRGLVYGLGVYIPFMAYCSAT 985
+ TV+S E QKF++ L+ AVAY W + G+ + + + Y
Sbjct: 374 MPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGIL-YIGGQ 432
Query: 986 VYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYAPSLNTAKACGARILSIIQRQPK 1045
+ + V+ G LV V + + + +Y P + A +I + R P+
Sbjct: 433 LVTSGAVSSGN----LVTFVLYQMQFTQALEVLLSIY-PRVQKAVGSSEKIFEYLDRTPR 487
Query: 1046 IHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGK 1105
+ G+ G +DV F YP RP VL+G+ + G+ ALVG +G GK
Sbjct: 488 CPPS-GLLTPLH--LEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGK 544
Query: 1106 STILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGD 1165
ST+ L Q Y P G + LD + + L RQ+ V QEP + RSL ENIAYG
Sbjct: 545 STVAALLQNLYQPTGGQLLLDGKPL-PQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYG- 602
Query: 1166 NNRKVTMHEIVAAAKAANIHSFIVSLPK 1193
+K TM EI AAA + HSFI LP+
Sbjct: 603 LTQKPTMEEITAAAVKSGAHSFISGLPQ 630
Score = 42.7 bits (96), Expect = 0.008
Identities = 20/46 (43%), Positives = 27/46 (58%)
Query: 1206 RTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRM 1251
R+ + I LS V+ AD I ++ G I E GTH +L+ KG YW M
Sbjct: 694 RSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAM 739
>L21208-1|AAC12906.1| 748|Homo sapiens peptide transporter protein.
Length = 748
Score = 244 bits (596), Expect = 2e-63
Identities = 153/488 (31%), Positives = 256/488 (52%), Gaps = 21/488 (4%)
Query: 148 SVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPLGW- 206
+VLRQ+ ++ + N+ S+++E+ ++ + + E L++ + V LC + W
Sbjct: 267 AVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSL---FLWYLVRGLCLLGIMLWG 323
Query: 207 --QLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAFGGE 264
LT+ +P + + + ++ ES + + + A E L ++ T+ +F E
Sbjct: 324 SVSLTMVTLVTLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANE 383
Query: 265 NKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSY-GTRLVVNDFDTDS 323
E +++R L+ + +K + + N + ++ L +G Y G +LV + +
Sbjct: 384 EGEAQKFREKLQEIKTLNQKEAVAYAV-NSWTTSISGMLLKVGILYIGGQLVTSGAVSSG 442
Query: 324 NLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQK 383
NL + +Y + F+ A + + P ++ IF ++R P+
Sbjct: 443 NLVTF---VLYQMQFT--QAVEVLLSIYPRVQ---KAVGSSEKIFEYLDRTPRCPPSGL- 493
Query: 384 GLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQ 443
LTP + G + +DV F YP+RP+V VL+G + ++PGE ALVG +G GKSTV LLQ
Sbjct: 494 -LTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQ 552
Query: 444 RLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIG-SPEATREEI 502
LY P G + +L + VGQEP +F ++ +NIA G + + T EEI
Sbjct: 553 NLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEI 612
Query: 503 QRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSA 562
A + AH FIS LP GYDT + E G+ LSGGQ+Q +A+AR+L+R+P VL+LD+ATSA
Sbjct: 613 TAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSA 672
Query: 563 LDPHSERQVQAALDRA--SVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKA 620
LD +S+ QV+ L + R+ + ++ LS + AD I+ ++ G I E GTH+ LM+
Sbjct: 673 LDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEK 732
Query: 621 KGFYHKLV 628
KG Y +V
Sbjct: 733 KGCYWAMV 740
Score = 137 bits (332), Expect = 2e-31
Identities = 117/397 (29%), Positives = 188/397 (47%), Gaps = 23/397 (5%)
Query: 814 TRLRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGI--SSV 871
+ L+ + F ++L+QE FF + N G I +R++ DT+ + + + L L +
Sbjct: 258 SHLQGEVFGAVLRQETEFFQQ--NQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLC 315
Query: 872 VVGFLLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVS 931
++G +L S + LT+V V LPL+ G Q ++ R ++ ++ +A EA+ +
Sbjct: 316 LLGIMLWGSVS--LTMVTLVTLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSA 373
Query: 932 IKTVQSLGVETVFLQKFQDALKTACV-----AVAYKTR-WRGLVYGLGVYIPFMAYCSAT 985
+ TV+S E QKF++ L+ AVAY W + G+ + + + Y
Sbjct: 374 MPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGIL-YIGGQ 432
Query: 986 VYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYAPSLNTAKACGARILSIIQRQPK 1045
+ + V+ G LV V + + + +Y P + A +I + R P+
Sbjct: 433 LVTSGAVSSGN----LVTFVLYQMQFTQAVEVLLSIY-PRVQKAVGSSEKIFEYLDRTPR 487
Query: 1046 IHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGK 1105
+ G+ G +DV F YP RP VL+G+ + G+ ALVG +G GK
Sbjct: 488 CPPS-GLLTPLH--LEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGK 544
Query: 1106 STILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGD 1165
ST+ L Q Y P G + LD + + L RQ+ V QEP + RSL ENIAYG
Sbjct: 545 STVAALLQNLYQPTGGQLLLDGKPL-PQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYG- 602
Query: 1166 NNRKVTMHEIVAAAKAANIHSFIVSLPKAVTEALEKA 1202
+K TM EI AAA + HSFI LP+ +++A
Sbjct: 603 LTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEA 639
Score = 42.7 bits (96), Expect = 0.008
Identities = 20/46 (43%), Positives = 27/46 (58%)
Query: 1206 RTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRM 1251
R+ + I LS V+ AD I ++ G I E GTH +L+ KG YW M
Sbjct: 694 RSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAM 739
>X87344-5|CAA60785.1| 748|Homo sapiens TAP1 protein.
Length = 748
Score = 243 bits (595), Expect = 3e-63
Identities = 153/488 (31%), Positives = 256/488 (52%), Gaps = 21/488 (4%)
Query: 148 SVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPLGW- 206
+VLRQ+ ++ + N+ S+++E+ ++ + + E L++ + V LC + W
Sbjct: 267 AVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSL---FLWYLVRGLCLLGIMLWG 323
Query: 207 --QLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAFGGE 264
LT+ +P + + + ++ ES + + + A E L ++ T+ +F E
Sbjct: 324 SVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANE 383
Query: 265 NKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSY-GTRLVVNDFDTDS 323
E +++R L+ + +K + + N + ++ L +G Y G +LV + +
Sbjct: 384 EGEAQKFREKLQEIKTLNQKEAVAYAV-NSWTTSISGMLLKVGILYIGGQLVTSGAVSSG 442
Query: 324 NLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQK 383
NL + +Y + F+ A + + P ++ IF ++R P+
Sbjct: 443 NLVTF---VLYQMQFT--QAVEVLLSIYPRVQ---KAVGSSEKIFEYLDRTPRCPPSGL- 493
Query: 384 GLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQ 443
LTP + G + +DV F YP+RP+V VL+G + ++PGE ALVG +G GKSTV LLQ
Sbjct: 494 -LTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQ 552
Query: 444 RLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIG-SPEATREEI 502
LY P G + +L + VGQEP +F ++ +NIA G + + T EEI
Sbjct: 553 NLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEI 612
Query: 503 QRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSA 562
A + AH FIS LP GYDT + E G+ LSGGQ+Q +A+AR+L+R+P VL+LD+ATSA
Sbjct: 613 TAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSA 672
Query: 563 LDPHSERQVQAALDRA--SVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKA 620
LD +S+ QV+ L + R+ + ++ LS + AD I+ ++ G I E GTH+ LM+
Sbjct: 673 LDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEK 732
Query: 621 KGFYHKLV 628
KG Y +V
Sbjct: 733 KGCYWAMV 740
Score = 137 bits (331), Expect = 3e-31
Identities = 116/397 (29%), Positives = 188/397 (47%), Gaps = 23/397 (5%)
Query: 814 TRLRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGI--SSV 871
+ L+ + F ++L+QE FF + N G I +R++ DT+ + + + L L +
Sbjct: 258 SHLQGEVFGAVLRQETEFFQQ--NQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLC 315
Query: 872 VVGFLLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVS 931
++G +L S + LT+V + LPL+ G Q ++ R ++ ++ +A EA+ +
Sbjct: 316 LLGIMLWGSVS--LTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSA 373
Query: 932 IKTVQSLGVETVFLQKFQDALKTACV-----AVAYKTR-WRGLVYGLGVYIPFMAYCSAT 985
+ TV+S E QKF++ L+ AVAY W + G+ + + + Y
Sbjct: 374 MPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGIL-YIGGQ 432
Query: 986 VYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYAPSLNTAKACGARILSIIQRQPK 1045
+ + V+ G LV V + + + +Y P + A +I + R P+
Sbjct: 433 LVTSGAVSSGN----LVTFVLYQMQFTQAVEVLLSIY-PRVQKAVGSSEKIFEYLDRTPR 487
Query: 1046 IHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGK 1105
+ G+ G +DV F YP RP VL+G+ + G+ ALVG +G GK
Sbjct: 488 CPPS-GLLTPLH--LEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGK 544
Query: 1106 STILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGD 1165
ST+ L Q Y P G + LD + + L RQ+ V QEP + RSL ENIAYG
Sbjct: 545 STVAALLQNLYQPTGGQLLLDGKPL-PQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYG- 602
Query: 1166 NNRKVTMHEIVAAAKAANIHSFIVSLPKAVTEALEKA 1202
+K TM EI AAA + HSFI LP+ +++A
Sbjct: 603 LTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEA 639
Score = 42.7 bits (96), Expect = 0.008
Identities = 20/46 (43%), Positives = 27/46 (58%)
Query: 1206 RTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRM 1251
R+ + I LS V+ AD I ++ G I E GTH +L+ KG YW M
Sbjct: 694 RSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAM 739
>X66401-2|CAA47025.1| 748|Homo sapiens ABC-transporter protein.
Length = 748
Score = 243 bits (595), Expect = 3e-63
Identities = 153/488 (31%), Positives = 256/488 (52%), Gaps = 21/488 (4%)
Query: 148 SVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPLGW- 206
+VLRQ+ ++ + N+ S+++E+ ++ + + E L++ + V LC + W
Sbjct: 267 AVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSL---FLWYLVRGLCLLGIMLWG 323
Query: 207 --QLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAFGGE 264
LT+ +P + + + ++ ES + + + A E L ++ T+ +F E
Sbjct: 324 SVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANE 383
Query: 265 NKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSY-GTRLVVNDFDTDS 323
E +++R L+ + +K + + N + ++ L +G Y G +LV + +
Sbjct: 384 EGEAQKFREKLQEIKTLNQKEAVAYAV-NSWTTSISGMLLKVGILYIGGQLVTSGAVSSG 442
Query: 324 NLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQK 383
NL + +Y + F+ A + + P ++ IF ++R P+
Sbjct: 443 NLVTF---VLYQMQFT--QAVEVLLSIYPRVQ---KAVGSSEKIFEYLDRTPRCPPSGL- 493
Query: 384 GLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQ 443
LTP + G + +DV F YP+RP+V VL+G + ++PGE ALVG +G GKSTV LLQ
Sbjct: 494 -LTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQ 552
Query: 444 RLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIG-SPEATREEI 502
LY P G + +L + VGQEP +F ++ +NIA G + + T EEI
Sbjct: 553 NLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEI 612
Query: 503 QRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSA 562
A + AH FIS LP GYDT + E G+ LSGGQ+Q +A+AR+L+R+P VL+LD+ATSA
Sbjct: 613 TAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSA 672
Query: 563 LDPHSERQVQAALDRA--SVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKA 620
LD +S+ QV+ L + R+ + ++ LS + AD I+ ++ G I E GTH+ LM+
Sbjct: 673 LDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEK 732
Query: 621 KGFYHKLV 628
KG Y +V
Sbjct: 733 KGCYWAMV 740
Score = 137 bits (331), Expect = 3e-31
Identities = 116/397 (29%), Positives = 188/397 (47%), Gaps = 23/397 (5%)
Query: 814 TRLRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGI--SSV 871
+ L+ + F ++L+QE FF + N G I +R++ DT+ + + + L L +
Sbjct: 258 SHLQGEVFGAVLRQETEFFQQ--NQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLC 315
Query: 872 VVGFLLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVS 931
++G +L S + LT+V + LPL+ G Q ++ R ++ ++ +A EA+ +
Sbjct: 316 LLGIMLWGSVS--LTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSA 373
Query: 932 IKTVQSLGVETVFLQKFQDALKTACV-----AVAYKTR-WRGLVYGLGVYIPFMAYCSAT 985
+ TV+S E QKF++ L+ AVAY W + G+ + + + Y
Sbjct: 374 MPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGIL-YIGGQ 432
Query: 986 VYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYAPSLNTAKACGARILSIIQRQPK 1045
+ + V+ G LV V + + + +Y P + A +I + R P+
Sbjct: 433 LVTSGAVSSGN----LVTFVLYQMQFTQAVEVLLSIY-PRVQKAVGSSEKIFEYLDRTPR 487
Query: 1046 IHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGK 1105
+ G+ G +DV F YP RP VL+G+ + G+ ALVG +G GK
Sbjct: 488 CPPS-GLLTPLH--LEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGK 544
Query: 1106 STILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGD 1165
ST+ L Q Y P G + LD + + L RQ+ V QEP + RSL ENIAYG
Sbjct: 545 STVAALLQNLYQPTGGQLLLDGKPL-PQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYG- 602
Query: 1166 NNRKVTMHEIVAAAKAANIHSFIVSLPKAVTEALEKA 1202
+K TM EI AAA + HSFI LP+ +++A
Sbjct: 603 LTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEA 639
Score = 42.7 bits (96), Expect = 0.008
Identities = 20/46 (43%), Positives = 27/46 (58%)
Query: 1206 RTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRM 1251
R+ + I LS V+ AD I ++ G I E GTH +L+ KG YW M
Sbjct: 694 RSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAM 739
>X57522-1|CAA40741.1| 808|Homo sapiens peptide transporter protein.
Length = 808
Score = 243 bits (595), Expect = 3e-63
Identities = 153/488 (31%), Positives = 256/488 (52%), Gaps = 21/488 (4%)
Query: 148 SVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPLGW- 206
+VLRQ+ ++ + N+ S+++E+ ++ + + E L++ + V LC + W
Sbjct: 327 AVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSL---FLWYLVRGLCLLGIMLWG 383
Query: 207 --QLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAFGGE 264
LT+ +P + + + ++ ES + + + A E L ++ T+ +F E
Sbjct: 384 SVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANE 443
Query: 265 NKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSY-GTRLVVNDFDTDS 323
E +++R L+ + +K + + N + ++ L +G Y G +LV + +
Sbjct: 444 EGEAQKFREKLQEIKTLNQKEAVAYAV-NSWTTSISGMLLKVGILYIGGQLVTSGAVSSG 502
Query: 324 NLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQK 383
NL + +Y + F+ A + + P ++ IF ++R P+
Sbjct: 503 NLVTF---VLYQMQFT--QAVEVLLSIYPRVQ---KAVGSSEKIFEYLDRTPRCPPSGL- 553
Query: 384 GLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQ 443
LTP + G + +DV F YP+RP+V VL+G + ++PGE ALVG +G GKSTV LLQ
Sbjct: 554 -LTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQ 612
Query: 444 RLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIG-SPEATREEI 502
LY P G + +L + VGQEP +F ++ +NIA G + + T EEI
Sbjct: 613 NLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEI 672
Query: 503 QRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSA 562
A + AH FIS LP GYDT + E G+ LSGGQ+Q +A+AR+L+R+P VL+LD+ATSA
Sbjct: 673 TAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSA 732
Query: 563 LDPHSERQVQAALDRA--SVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKA 620
LD +S+ QV+ L + R+ + ++ LS + AD I+ ++ G I E GTH+ LM+
Sbjct: 733 LDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEK 792
Query: 621 KGFYHKLV 628
KG Y +V
Sbjct: 793 KGCYWAMV 800
Score = 137 bits (331), Expect = 3e-31
Identities = 116/397 (29%), Positives = 188/397 (47%), Gaps = 23/397 (5%)
Query: 814 TRLRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGI--SSV 871
+ L+ + F ++L+QE FF + N G I +R++ DT+ + + + L L +
Sbjct: 318 SHLQGEVFGAVLRQETEFFQQ--NQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLC 375
Query: 872 VVGFLLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVS 931
++G +L S + LT+V + LPL+ G Q ++ R ++ ++ +A EA+ +
Sbjct: 376 LLGIMLWGSVS--LTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSA 433
Query: 932 IKTVQSLGVETVFLQKFQDALKTACV-----AVAYKTR-WRGLVYGLGVYIPFMAYCSAT 985
+ TV+S E QKF++ L+ AVAY W + G+ + + + Y
Sbjct: 434 MPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGIL-YIGGQ 492
Query: 986 VYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYAPSLNTAKACGARILSIIQRQPK 1045
+ + V+ G LV V + + + +Y P + A +I + R P+
Sbjct: 493 LVTSGAVSSGN----LVTFVLYQMQFTQAVEVLLSIY-PRVQKAVGSSEKIFEYLDRTPR 547
Query: 1046 IHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGK 1105
+ G+ G +DV F YP RP VL+G+ + G+ ALVG +G GK
Sbjct: 548 CPPS-GLLTPLH--LEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGK 604
Query: 1106 STILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGD 1165
ST+ L Q Y P G + LD + + L RQ+ V QEP + RSL ENIAYG
Sbjct: 605 STVAALLQNLYQPTGGQLLLDGKPL-PQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYG- 662
Query: 1166 NNRKVTMHEIVAAAKAANIHSFIVSLPKAVTEALEKA 1202
+K TM EI AAA + HSFI LP+ +++A
Sbjct: 663 LTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEA 699
Score = 42.7 bits (96), Expect = 0.008
Identities = 20/46 (43%), Positives = 27/46 (58%)
Query: 1206 RTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRM 1251
R+ + I LS V+ AD I ++ G I E GTH +L+ KG YW M
Sbjct: 754 RSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAM 799
>L21204-1|AAC12902.1| 748|Homo sapiens peptide transporter protein.
Length = 748
Score = 243 bits (595), Expect = 3e-63
Identities = 153/488 (31%), Positives = 256/488 (52%), Gaps = 21/488 (4%)
Query: 148 SVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPLGW- 206
+VLRQ+ ++ + N+ S+++E+ ++ + + E L++ + V LC + W
Sbjct: 267 AVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSL---FLWYLVRGLCLLGIMLWG 323
Query: 207 --QLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAFGGE 264
LT+ +P + + + ++ ES + + + A E L ++ T+ +F E
Sbjct: 324 SVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANE 383
Query: 265 NKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSY-GTRLVVNDFDTDS 323
E +++R L+ + +K + + N + ++ L +G Y G +LV + +
Sbjct: 384 EGEAQKFREKLQEIKTLNQKEAVAYAV-NSWTTSISGMLLKVGILYIGGQLVTSGAVSSG 442
Query: 324 NLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQK 383
NL + +Y + F+ A + + P ++ IF ++R P+
Sbjct: 443 NLVTF---VLYQMQFT--QAVEVLLSIYPRVQ---KAVGSSEKIFEYLDRTPRCPPSGL- 493
Query: 384 GLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQ 443
LTP + G + +DV F YP+RP+V VL+G + ++PGE ALVG +G GKSTV LLQ
Sbjct: 494 -LTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQ 552
Query: 444 RLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIG-SPEATREEI 502
LY P G + +L + VGQEP +F ++ +NIA G + + T EEI
Sbjct: 553 NLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEI 612
Query: 503 QRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSA 562
A + AH FIS LP GYDT + E G+ LSGGQ+Q +A+AR+L+R+P VL+LD+ATSA
Sbjct: 613 TAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSA 672
Query: 563 LDPHSERQVQAALDRA--SVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKA 620
LD +S+ QV+ L + R+ + ++ LS + AD I+ ++ G I E GTH+ LM+
Sbjct: 673 LDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEK 732
Query: 621 KGFYHKLV 628
KG Y +V
Sbjct: 733 KGCYWAMV 740
Score = 137 bits (331), Expect = 3e-31
Identities = 116/397 (29%), Positives = 188/397 (47%), Gaps = 23/397 (5%)
Query: 814 TRLRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGI--SSV 871
+ L+ + F ++L+QE FF + N G I +R++ DT+ + + + L L +
Sbjct: 258 SHLQGEVFGAVLRQETEFFQQ--NQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLC 315
Query: 872 VVGFLLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVS 931
++G +L S + LT+V + LPL+ G Q ++ R ++ ++ +A EA+ +
Sbjct: 316 LLGIMLWGSVS--LTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSA 373
Query: 932 IKTVQSLGVETVFLQKFQDALKTACV-----AVAYKTR-WRGLVYGLGVYIPFMAYCSAT 985
+ TV+S E QKF++ L+ AVAY W + G+ + + + Y
Sbjct: 374 MPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGIL-YIGGQ 432
Query: 986 VYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYAPSLNTAKACGARILSIIQRQPK 1045
+ + V+ G LV V + + + +Y P + A +I + R P+
Sbjct: 433 LVTSGAVSSGN----LVTFVLYQMQFTQAVEVLLSIY-PRVQKAVGSSEKIFEYLDRTPR 487
Query: 1046 IHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGK 1105
+ G+ G +DV F YP RP VL+G+ + G+ ALVG +G GK
Sbjct: 488 CPPS-GLLTPLH--LEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGK 544
Query: 1106 STILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGD 1165
ST+ L Q Y P G + LD + + L RQ+ V QEP + RSL ENIAYG
Sbjct: 545 STVAALLQNLYQPTGGQLLLDGKPL-PQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYG- 602
Query: 1166 NNRKVTMHEIVAAAKAANIHSFIVSLPKAVTEALEKA 1202
+K TM EI AAA + HSFI LP+ +++A
Sbjct: 603 LTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEA 639
Score = 42.7 bits (96), Expect = 0.008
Identities = 20/46 (43%), Positives = 27/46 (58%)
Query: 1206 RTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRM 1251
R+ + I LS V+ AD I ++ G I E GTH +L+ KG YW M
Sbjct: 694 RSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAM 739
>BX088556-4|CAM26263.1| 808|Homo sapiens transporter 1 ATP-binding
cassette sub-family B (MDR/TAP) protein.
Length = 808
Score = 243 bits (595), Expect = 3e-63
Identities = 153/488 (31%), Positives = 256/488 (52%), Gaps = 21/488 (4%)
Query: 148 SVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPLGW- 206
+VLRQ+ ++ + N+ S+++E+ ++ + + E L++ + V LC + W
Sbjct: 327 AVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSL---FLWYLVRGLCLLGIMLWG 383
Query: 207 --QLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAFGGE 264
LT+ +P + + + ++ ES + + + A E L ++ T+ +F E
Sbjct: 384 SVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANE 443
Query: 265 NKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSY-GTRLVVNDFDTDS 323
E +++R L+ + +K + + N + ++ L +G Y G +LV + +
Sbjct: 444 EGEAQKFREKLQEIKTLNQKEAVAYAV-NSWTTSISGMLLKVGILYIGGQLVTSGAVSSG 502
Query: 324 NLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQK 383
NL + +Y + F+ A + + P ++ IF ++R P+
Sbjct: 503 NLVTF---VLYQMQFT--QAVEVLLSIYPRVQ---KAVGSSEKIFEYLDRTPRCPPSGL- 553
Query: 384 GLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQ 443
LTP + G + +DV F YP+RP+V VL+G + ++PGE ALVG +G GKSTV LLQ
Sbjct: 554 -LTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQ 612
Query: 444 RLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIG-SPEATREEI 502
LY P G + +L + VGQEP +F ++ +NIA G + + T EEI
Sbjct: 613 NLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEI 672
Query: 503 QRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSA 562
A + AH FIS LP GYDT + E G+ LSGGQ+Q +A+AR+L+R+P VL+LD+ATSA
Sbjct: 673 TAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSA 732
Query: 563 LDPHSERQVQAALDRA--SVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKA 620
LD +S+ QV+ L + R+ + ++ LS + AD I+ ++ G I E GTH+ LM+
Sbjct: 733 LDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEK 792
Query: 621 KGFYHKLV 628
KG Y +V
Sbjct: 793 KGCYWAMV 800
Score = 137 bits (331), Expect = 3e-31
Identities = 116/397 (29%), Positives = 188/397 (47%), Gaps = 23/397 (5%)
Query: 814 TRLRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGI--SSV 871
+ L+ + F ++L+QE FF + N G I +R++ DT+ + + + L L +
Sbjct: 318 SHLQGEVFGAVLRQETEFFQQ--NQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLC 375
Query: 872 VVGFLLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVS 931
++G +L S + LT+V + LPL+ G Q ++ R ++ ++ +A EA+ +
Sbjct: 376 LLGIMLWGSVS--LTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSA 433
Query: 932 IKTVQSLGVETVFLQKFQDALKTACV-----AVAYKTR-WRGLVYGLGVYIPFMAYCSAT 985
+ TV+S E QKF++ L+ AVAY W + G+ + + + Y
Sbjct: 434 MPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGIL-YIGGQ 492
Query: 986 VYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYAPSLNTAKACGARILSIIQRQPK 1045
+ + V+ G LV V + + + +Y P + A +I + R P+
Sbjct: 493 LVTSGAVSSGN----LVTFVLYQMQFTQAVEVLLSIY-PRVQKAVGSSEKIFEYLDRTPR 547
Query: 1046 IHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGK 1105
+ G+ G +DV F YP RP VL+G+ + G+ ALVG +G GK
Sbjct: 548 CPPS-GLLTPLH--LEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGK 604
Query: 1106 STILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGD 1165
ST+ L Q Y P G + LD + + L RQ+ V QEP + RSL ENIAYG
Sbjct: 605 STVAALLQNLYQPTGGQLLLDGKPL-PQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYG- 662
Query: 1166 NNRKVTMHEIVAAAKAANIHSFIVSLPKAVTEALEKA 1202
+K TM EI AAA + HSFI LP+ +++A
Sbjct: 663 LTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEA 699
Score = 42.7 bits (96), Expect = 0.008
Identities = 20/46 (43%), Positives = 27/46 (58%)
Query: 1206 RTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRM 1251
R+ + I LS V+ AD I ++ G I E GTH +L+ KG YW M
Sbjct: 754 RSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAM 799
>BC014081-1|AAH14081.1| 808|Homo sapiens transporter 1, ATP-binding
cassette, sub-family B (MDR/TAP) protein.
Length = 808
Score = 243 bits (595), Expect = 3e-63
Identities = 153/488 (31%), Positives = 256/488 (52%), Gaps = 21/488 (4%)
Query: 148 SVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPLGW- 206
+VLRQ+ ++ + N+ S+++E+ ++ + + E L++ + V LC + W
Sbjct: 327 AVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSL---FLWYLVRGLCLLGIMLWG 383
Query: 207 --QLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAFGGE 264
LT+ +P + + + ++ ES + + + A E L ++ T+ +F E
Sbjct: 384 SVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANE 443
Query: 265 NKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSY-GTRLVVNDFDTDS 323
E +++R L+ + +K + + N + ++ L +G Y G +LV + +
Sbjct: 444 EGEAQKFREKLQEIKTLNQKEAVAYAV-NSWTTSISGMLLKVGILYIGGQLVTSGAVSSG 502
Query: 324 NLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQK 383
NL + +Y + F+ A + + P ++ IF ++R P+
Sbjct: 503 NLVTF---VLYQMQFT--QAVEVLLSIYPRVQ---KAVGSSEKIFEYLDRTPRCPPSGL- 553
Query: 384 GLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQ 443
LTP + G + +DV F YP+RP+V VL+G + ++PGE ALVG +G GKSTV LLQ
Sbjct: 554 -LTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQ 612
Query: 444 RLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIG-SPEATREEI 502
LY P G + +L + VGQEP +F ++ +NIA G + + T EEI
Sbjct: 613 NLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEI 672
Query: 503 QRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSA 562
A + AH FIS LP GYDT + E G+ LSGGQ+Q +A+AR+L+R+P VL+LD+ATSA
Sbjct: 673 TAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSA 732
Query: 563 LDPHSERQVQAALDRA--SVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKA 620
LD +S+ QV+ L + R+ + ++ LS + AD I+ ++ G I E GTH+ LM+
Sbjct: 733 LDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEK 792
Query: 621 KGFYHKLV 628
KG Y +V
Sbjct: 793 KGCYWAMV 800
Score = 137 bits (331), Expect = 3e-31
Identities = 116/397 (29%), Positives = 188/397 (47%), Gaps = 23/397 (5%)
Query: 814 TRLRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGI--SSV 871
+ L+ + F ++L+QE FF + N G I +R++ DT+ + + + L L +
Sbjct: 318 SHLQGEVFGAVLRQETEFFQQ--NQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLC 375
Query: 872 VVGFLLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVS 931
++G +L S + LT+V + LPL+ G Q ++ R ++ ++ +A EA+ +
Sbjct: 376 LLGIMLWGSVS--LTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSA 433
Query: 932 IKTVQSLGVETVFLQKFQDALKTACV-----AVAYKTR-WRGLVYGLGVYIPFMAYCSAT 985
+ TV+S E QKF++ L+ AVAY W + G+ + + + Y
Sbjct: 434 MPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGIL-YIGGQ 492
Query: 986 VYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYAPSLNTAKACGARILSIIQRQPK 1045
+ + V+ G LV V + + + +Y P + A +I + R P+
Sbjct: 493 LVTSGAVSSGN----LVTFVLYQMQFTQAVEVLLSIY-PRVQKAVGSSEKIFEYLDRTPR 547
Query: 1046 IHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGK 1105
+ G+ G +DV F YP RP VL+G+ + G+ ALVG +G GK
Sbjct: 548 CPPS-GLLTPLH--LEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGK 604
Query: 1106 STILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGD 1165
ST+ L Q Y P G + LD + + L RQ+ V QEP + RSL ENIAYG
Sbjct: 605 STVAALLQNLYQPTGGQLLLDGKPL-PQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYG- 662
Query: 1166 NNRKVTMHEIVAAAKAANIHSFIVSLPKAVTEALEKA 1202
+K TM EI AAA + HSFI LP+ +++A
Sbjct: 663 LTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEA 699
Score = 42.7 bits (96), Expect = 0.008
Identities = 20/46 (43%), Positives = 27/46 (58%)
Query: 1206 RTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRM 1251
R+ + I LS V+ AD I ++ G I E GTH +L+ KG YW M
Sbjct: 754 RSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAM 799
>AL935043-6|CAI18626.1| 808|Homo sapiens transporter 1, ATP-binding
cassette, sub-family Bpha protein.
Length = 808
Score = 243 bits (595), Expect = 3e-63
Identities = 153/488 (31%), Positives = 256/488 (52%), Gaps = 21/488 (4%)
Query: 148 SVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPLGW- 206
+VLRQ+ ++ + N+ S+++E+ ++ + + E L++ + V LC + W
Sbjct: 327 AVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSL---FLWYLVRGLCLLGIMLWG 383
Query: 207 --QLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAFGGE 264
LT+ +P + + + ++ ES + + + A E L ++ T+ +F E
Sbjct: 384 SVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANE 443
Query: 265 NKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSY-GTRLVVNDFDTDS 323
E +++R L+ + +K + + N + ++ L +G Y G +LV + +
Sbjct: 444 EGEAQKFREKLQEIKTLNQKEAVAYAV-NSWTTSISGMLLKVGILYIGGQLVTSGAVSSG 502
Query: 324 NLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQK 383
NL + +Y + F+ A + + P ++ IF ++R P+
Sbjct: 503 NLVTF---VLYQMQFT--QAVEVLLSIYPRVQ---KAVGSSEKIFEYLDRTPRCPPSGL- 553
Query: 384 GLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQ 443
LTP + G + +DV F YP+RP+V VL+G + ++PGE ALVG +G GKSTV LLQ
Sbjct: 554 -LTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQ 612
Query: 444 RLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIG-SPEATREEI 502
LY P G + +L + VGQEP +F ++ +NIA G + + T EEI
Sbjct: 613 NLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEI 672
Query: 503 QRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSA 562
A + AH FIS LP GYDT + E G+ LSGGQ+Q +A+AR+L+R+P VL+LD+ATSA
Sbjct: 673 TAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSA 732
Query: 563 LDPHSERQVQAALDRA--SVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKA 620
LD +S+ QV+ L + R+ + ++ LS + AD I+ ++ G I E GTH+ LM+
Sbjct: 733 LDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEK 792
Query: 621 KGFYHKLV 628
KG Y +V
Sbjct: 793 KGCYWAMV 800
Score = 137 bits (331), Expect = 3e-31
Identities = 116/397 (29%), Positives = 188/397 (47%), Gaps = 23/397 (5%)
Query: 814 TRLRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGI--SSV 871
+ L+ + F ++L+QE FF + N G I +R++ DT+ + + + L L +
Sbjct: 318 SHLQGEVFGAVLRQETEFFQQ--NQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLC 375
Query: 872 VVGFLLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVS 931
++G +L S + LT+V + LPL+ G Q ++ R ++ ++ +A EA+ +
Sbjct: 376 LLGIMLWGSVS--LTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSA 433
Query: 932 IKTVQSLGVETVFLQKFQDALKTACV-----AVAYKTR-WRGLVYGLGVYIPFMAYCSAT 985
+ TV+S E QKF++ L+ AVAY W + G+ + + + Y
Sbjct: 434 MPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGIL-YIGGQ 492
Query: 986 VYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYAPSLNTAKACGARILSIIQRQPK 1045
+ + V+ G LV V + + + +Y P + A +I + R P+
Sbjct: 493 LVTSGAVSSGN----LVTFVLYQMQFTQAVEVLLSIY-PRVQKAVGSSEKIFEYLDRTPR 547
Query: 1046 IHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGK 1105
+ G+ G +DV F YP RP VL+G+ + G+ ALVG +G GK
Sbjct: 548 CPPS-GLLTPLH--LEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGK 604
Query: 1106 STILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGD 1165
ST+ L Q Y P G + LD + + L RQ+ V QEP + RSL ENIAYG
Sbjct: 605 STVAALLQNLYQPTGGQLLLDGKPL-PQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYG- 662
Query: 1166 NNRKVTMHEIVAAAKAANIHSFIVSLPKAVTEALEKA 1202
+K TM EI AAA + HSFI LP+ +++A
Sbjct: 663 LTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEA 699
Score = 42.7 bits (96), Expect = 0.008
Identities = 20/46 (43%), Positives = 27/46 (58%)
Query: 1206 RTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRM 1251
R+ + I LS V+ AD I ++ G I E GTH +L+ KG YW M
Sbjct: 754 RSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAM 799
>AL671681-12|CAI17714.1| 808|Homo sapiens transporter 1,
ATP-binding cassette, sub-family Be, 9 (large
multifunctional pe protein.
Length = 808
Score = 243 bits (595), Expect = 3e-63
Identities = 153/488 (31%), Positives = 256/488 (52%), Gaps = 21/488 (4%)
Query: 148 SVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPLGW- 206
+VLRQ+ ++ + N+ S+++E+ ++ + + E L++ + V LC + W
Sbjct: 327 AVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSL---FLWYLVRGLCLLGIMLWG 383
Query: 207 --QLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAFGGE 264
LT+ +P + + + ++ ES + + + A E L ++ T+ +F E
Sbjct: 384 SVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANE 443
Query: 265 NKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSY-GTRLVVNDFDTDS 323
E +++R L+ + +K + + N + ++ L +G Y G +LV + +
Sbjct: 444 EGEAQKFREKLQEIKTLNQKEAVAYAV-NSWTTSISGMLLKVGILYIGGQLVTSGAVSSG 502
Query: 324 NLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQK 383
NL + +Y + F+ A + + P ++ IF ++R P+
Sbjct: 503 NLVTF---VLYQMQFT--QAVEVLLSIYPRVQ---KAVGSSEKIFEYLDRTPRCPPSGL- 553
Query: 384 GLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQ 443
LTP + G + +DV F YP+RP+V VL+G + ++PGE ALVG +G GKSTV LLQ
Sbjct: 554 -LTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQ 612
Query: 444 RLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIG-SPEATREEI 502
LY P G + +L + VGQEP +F ++ +NIA G + + T EEI
Sbjct: 613 NLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEI 672
Query: 503 QRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSA 562
A + AH FIS LP GYDT + E G+ LSGGQ+Q +A+AR+L+R+P VL+LD+ATSA
Sbjct: 673 TAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSA 732
Query: 563 LDPHSERQVQAALDRA--SVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKA 620
LD +S+ QV+ L + R+ + ++ LS + AD I+ ++ G I E GTH+ LM+
Sbjct: 733 LDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEK 792
Query: 621 KGFYHKLV 628
KG Y +V
Sbjct: 793 KGCYWAMV 800
Score = 137 bits (331), Expect = 3e-31
Identities = 116/397 (29%), Positives = 188/397 (47%), Gaps = 23/397 (5%)
Query: 814 TRLRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGI--SSV 871
+ L+ + F ++L+QE FF + N G I +R++ DT+ + + + L L +
Sbjct: 318 SHLQGEVFGAVLRQETEFFQQ--NQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLC 375
Query: 872 VVGFLLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVS 931
++G +L S + LT+V + LPL+ G Q ++ R ++ ++ +A EA+ +
Sbjct: 376 LLGIMLWGSVS--LTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSA 433
Query: 932 IKTVQSLGVETVFLQKFQDALKTACV-----AVAYKTR-WRGLVYGLGVYIPFMAYCSAT 985
+ TV+S E QKF++ L+ AVAY W + G+ + + + Y
Sbjct: 434 MPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGIL-YIGGQ 492
Query: 986 VYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYAPSLNTAKACGARILSIIQRQPK 1045
+ + V+ G LV V + + + +Y P + A +I + R P+
Sbjct: 493 LVTSGAVSSGN----LVTFVLYQMQFTQAVEVLLSIY-PRVQKAVGSSEKIFEYLDRTPR 547
Query: 1046 IHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGK 1105
+ G+ G +DV F YP RP VL+G+ + G+ ALVG +G GK
Sbjct: 548 CPPS-GLLTPLH--LEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGK 604
Query: 1106 STILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGD 1165
ST+ L Q Y P G + LD + + L RQ+ V QEP + RSL ENIAYG
Sbjct: 605 STVAALLQNLYQPTGGQLLLDGKPL-PQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYG- 662
Query: 1166 NNRKVTMHEIVAAAKAANIHSFIVSLPKAVTEALEKA 1202
+K TM EI AAA + HSFI LP+ +++A
Sbjct: 663 LTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEA 699
Score = 42.7 bits (96), Expect = 0.008
Identities = 20/46 (43%), Positives = 27/46 (58%)
Query: 1206 RTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRM 1251
R+ + I LS V+ AD I ++ G I E GTH +L+ KG YW M
Sbjct: 754 RSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAM 799
>AL669918-8|CAI18140.1| 808|Homo sapiens transporter 1, ATP-binding
cassette, sub-family Bpha protein.
Length = 808
Score = 243 bits (595), Expect = 3e-63
Identities = 153/488 (31%), Positives = 256/488 (52%), Gaps = 21/488 (4%)
Query: 148 SVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPLGW- 206
+VLRQ+ ++ + N+ S+++E+ ++ + + E L++ + V LC + W
Sbjct: 327 AVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSL---FLWYLVRGLCLLGIMLWG 383
Query: 207 --QLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAFGGE 264
LT+ +P + + + ++ ES + + + A E L ++ T+ +F E
Sbjct: 384 SVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANE 443
Query: 265 NKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSY-GTRLVVNDFDTDS 323
E +++R L+ + +K + + N + ++ L +G Y G +LV + +
Sbjct: 444 EGEAQKFREKLQEIKTLNQKEAVAYAV-NSWTTSISGMLLKVGILYIGGQLVTSGAVSSG 502
Query: 324 NLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQK 383
NL + +Y + F+ A + + P ++ IF ++R P+
Sbjct: 503 NLVTF---VLYQMQFT--QAVEVLLSIYPRVQ---KAVGSSEKIFEYLDRTPRCPPSGL- 553
Query: 384 GLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQ 443
LTP + G + +DV F YP+RP+V VL+G + ++PGE ALVG +G GKSTV LLQ
Sbjct: 554 -LTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQ 612
Query: 444 RLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIG-SPEATREEI 502
LY P G + +L + VGQEP +F ++ +NIA G + + T EEI
Sbjct: 613 NLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEI 672
Query: 503 QRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSA 562
A + AH FIS LP GYDT + E G+ LSGGQ+Q +A+AR+L+R+P VL+LD+ATSA
Sbjct: 673 TAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSA 732
Query: 563 LDPHSERQVQAALDRA--SVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKA 620
LD +S+ QV+ L + R+ + ++ LS + AD I+ ++ G I E GTH+ LM+
Sbjct: 733 LDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEK 792
Query: 621 KGFYHKLV 628
KG Y +V
Sbjct: 793 KGCYWAMV 800
Score = 137 bits (331), Expect = 3e-31
Identities = 116/397 (29%), Positives = 188/397 (47%), Gaps = 23/397 (5%)
Query: 814 TRLRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGI--SSV 871
+ L+ + F ++L+QE FF + N G I +R++ DT+ + + + L L +
Sbjct: 318 SHLQGEVFGAVLRQETEFFQQ--NQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLC 375
Query: 872 VVGFLLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVS 931
++G +L S + LT+V + LPL+ G Q ++ R ++ ++ +A EA+ +
Sbjct: 376 LLGIMLWGSVS--LTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSA 433
Query: 932 IKTVQSLGVETVFLQKFQDALKTACV-----AVAYKTR-WRGLVYGLGVYIPFMAYCSAT 985
+ TV+S E QKF++ L+ AVAY W + G+ + + + Y
Sbjct: 434 MPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGIL-YIGGQ 492
Query: 986 VYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYAPSLNTAKACGARILSIIQRQPK 1045
+ + V+ G LV V + + + +Y P + A +I + R P+
Sbjct: 493 LVTSGAVSSGN----LVTFVLYQMQFTQAVEVLLSIY-PRVQKAVGSSEKIFEYLDRTPR 547
Query: 1046 IHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGK 1105
+ G+ G +DV F YP RP VL+G+ + G+ ALVG +G GK
Sbjct: 548 CPPS-GLLTPLH--LEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGK 604
Query: 1106 STILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGD 1165
ST+ L Q Y P G + LD + + L RQ+ V QEP + RSL ENIAYG
Sbjct: 605 STVAALLQNLYQPTGGQLLLDGKPL-PQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYG- 662
Query: 1166 NNRKVTMHEIVAAAKAANIHSFIVSLPKAVTEALEKA 1202
+K TM EI AAA + HSFI LP+ +++A
Sbjct: 663 LTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEA 699
Score = 42.7 bits (96), Expect = 0.008
Identities = 20/46 (43%), Positives = 27/46 (58%)
Query: 1206 RTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRM 1251
R+ + I LS V+ AD I ++ G I E GTH +L+ KG YW M
Sbjct: 754 RSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAM 799
>X87344-8|CAA60788.1| 686|Homo sapiens TAP2 protein.
Length = 686
Score = 227 bits (556), Expect = 1e-58
Identities = 148/468 (31%), Positives = 238/468 (50%), Gaps = 14/468 (2%)
Query: 140 RIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLC 199
RIR S+LRQD+ ++ L S++S + + + V+ + V
Sbjct: 224 RIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYG 283
Query: 200 TAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREME-SYSLAGKQAEEILKSVRTI 258
+ +LTL MPF++ + N + + +RE++ + + AG+ E + ++T+
Sbjct: 284 FMLSISPRLTLLSLLHMPFTIAAE-KVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTV 342
Query: 259 VAFGGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVND 318
+FG E EV RY+ LE + +R L L VL + + S G + + +
Sbjct: 343 RSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDG 402
Query: 319 FDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKID 378
T +L + +Y Y+ Q++ + + +F ++R+P +
Sbjct: 403 ELTQGSLLSF---MIYQESVGSYV--QTLVYIYGDM---LSNVGAAEKVFSYMDRQPNLP 454
Query: 379 SLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTV 438
S L P + G + +DV F YP+RP+ VLKG + ++PGE ALVG +G GKSTV
Sbjct: 455 S--PGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV 512
Query: 439 LQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEAT 498
LLQ LY P G V +L S + VGQEPVLF G++ +NIA G
Sbjct: 513 AALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE 572
Query: 499 REEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 558
+++ A+ A+A DFI + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDE
Sbjct: 573 DDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDE 632
Query: 559 ATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQG 606
ATSALD E+ +Q R RT + ++HRL T+ A +I+ + +G
Sbjct: 633 ATSALDVQCEQALQDWNSRGD--RTVLVIAHRLQTVQRAHQILVLQEG 678
Score = 158 bits (383), Expect = 1e-37
Identities = 139/486 (28%), Positives = 238/486 (48%), Gaps = 26/486 (5%)
Query: 727 WQLLKLNAPEWPLITVGSIAAFLQGACFPVFALLFGFSSGIFILDNRDDIIYLADLYSVL 786
W+LLKL+ P+ PL+ +AAF + L SG I D A ++
Sbjct: 139 WRLLKLSRPDLPLL----VAAFFFLVLAVLGETLIPHYSGRVIDILGGDFDPHAFASAIF 194
Query: 787 FVVIAAV-AGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICAR 845
F+ + + + +S + FT ++ R+R Q F+SLL+Q++GFF +ET T G + +R
Sbjct: 195 FMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFF-QETKT-GELNSR 252
Query: 846 LSGDTAEVQGATGLRIGLILQGISSVV--VGFLLAISYNWKLTLVATVFLPLMVGSIWLE 903
LS DT + L ++L+ + VV GF+L+IS +LTL++ + +P + + +
Sbjct: 253 LSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISP--RLTLLSLLHMPFTIAAEKVY 310
Query: 904 GIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVAYKT 963
Q+ + ++A+ A + EAV ++TV+S G E + ++++AL+ C + ++
Sbjct: 311 NTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQ-CRQLYWRR 369
Query: 964 RWRGLVYGLGVYIPFMAYCSATVY-GAVLVAYGEMEYKLVL---LVNEAIMYGAYMLGQS 1019
+Y L + + + G + GE+ +L + E++ G+Y+
Sbjct: 370 DLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESV--GSYVQTLV 427
Query: 1020 LVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQ 1079
+Y L+ A ++ S + RQP + + + G +DV F YP RP +
Sbjct: 428 YIYGDMLSNVGAA-EKVFSYMDRQPNLPSPGTLAPT---TLQGVVKFQDVSFAYPNRPDR 483
Query: 1080 RVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRL 1139
VLKG+ + G+ ALVG +G GKST+ L Q Y P G + LD + I S L
Sbjct: 484 PVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPI-SQYEHCYL 542
Query: 1140 RRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAV-TEA 1198
Q+ V QEPVL S+ NIAYG + +++AAA+AA+ FI + + T+
Sbjct: 543 HSQVVSVGQEPVLFSGSVRNNIAYG--LQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDV 600
Query: 1199 LEKAAK 1204
EK ++
Sbjct: 601 GEKGSQ 606
>X66401-4|CAA47027.1| 686|Homo sapiens TAP2 protein.
Length = 686
Score = 227 bits (556), Expect = 1e-58
Identities = 148/468 (31%), Positives = 238/468 (50%), Gaps = 14/468 (2%)
Query: 140 RIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLC 199
RIR S+LRQD+ ++ L S++S + + + V+ + V
Sbjct: 224 RIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYG 283
Query: 200 TAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREME-SYSLAGKQAEEILKSVRTI 258
+ +LTL MPF++ + N + + +RE++ + + AG+ E + ++T+
Sbjct: 284 FMLSISPRLTLLSLLHMPFTIAAE-KVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTV 342
Query: 259 VAFGGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVND 318
+FG E EV RY+ LE + +R L L VL + + S G + + +
Sbjct: 343 RSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDG 402
Query: 319 FDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKID 378
T +L + +Y Y+ Q++ + + +F ++R+P +
Sbjct: 403 ELTQGSLLSF---MIYQESVGSYV--QTLVYIYGDM---LSNVGAAEKVFSYMDRQPNLP 454
Query: 379 SLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTV 438
S L P + G + +DV F YP+RP+ VLKG + ++PGE ALVG +G GKSTV
Sbjct: 455 S--PGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV 512
Query: 439 LQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEAT 498
LLQ LY P G V +L S + VGQEPVLF G++ +NIA G
Sbjct: 513 AALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE 572
Query: 499 REEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 558
+++ A+ A+A DFI + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDE
Sbjct: 573 DDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDE 632
Query: 559 ATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQG 606
ATSALD E+ +Q R RT + ++HRL T+ A +I+ + +G
Sbjct: 633 ATSALDVQCEQALQDWNSRGD--RTVLVIAHRLQTVQRAHQILVLQEG 678
Score = 158 bits (383), Expect = 1e-37
Identities = 139/486 (28%), Positives = 238/486 (48%), Gaps = 26/486 (5%)
Query: 727 WQLLKLNAPEWPLITVGSIAAFLQGACFPVFALLFGFSSGIFILDNRDDIIYLADLYSVL 786
W+LLKL+ P+ PL+ +AAF + L SG I D A ++
Sbjct: 139 WRLLKLSRPDLPLL----VAAFFFLVLAVLGETLIPHYSGRVIDILGGDFDPHAFASAIF 194
Query: 787 FVVIAAV-AGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICAR 845
F+ + + + +S + FT ++ R+R Q F+SLL+Q++GFF +ET T G + +R
Sbjct: 195 FMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFF-QETKT-GELNSR 252
Query: 846 LSGDTAEVQGATGLRIGLILQGISSVV--VGFLLAISYNWKLTLVATVFLPLMVGSIWLE 903
LS DT + L ++L+ + VV GF+L+IS +LTL++ + +P + + +
Sbjct: 253 LSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISP--RLTLLSLLHMPFTIAAEKVY 310
Query: 904 GIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVAYKT 963
Q+ + ++A+ A + EAV ++TV+S G E + ++++AL+ C + ++
Sbjct: 311 NTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQ-CRQLYWRR 369
Query: 964 RWRGLVYGLGVYIPFMAYCSATVY-GAVLVAYGEMEYKLVL---LVNEAIMYGAYMLGQS 1019
+Y L + + + G + GE+ +L + E++ G+Y+
Sbjct: 370 DLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESV--GSYVQTLV 427
Query: 1020 LVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQ 1079
+Y L+ A ++ S + RQP + + + G +DV F YP RP +
Sbjct: 428 YIYGDMLSNVGAA-EKVFSYMDRQPNLPSPGTLAPT---TLQGVVKFQDVSFAYPNRPDR 483
Query: 1080 RVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRL 1139
VLKG+ + G+ ALVG +G GKST+ L Q Y P G + LD + I S L
Sbjct: 484 PVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPI-SQYEHCYL 542
Query: 1140 RRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAV-TEA 1198
Q+ V QEPVL S+ NIAYG + +++AAA+AA+ FI + + T+
Sbjct: 543 HSQVVSVGQEPVLFSGSVRNNIAYG--LQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDV 600
Query: 1199 LEKAAK 1204
EK ++
Sbjct: 601 GEKGSQ 606
>U07844-1|AAA79901.1| 622|Homo sapiens ABC transport protein
protein.
Length = 622
Score = 227 bits (556), Expect = 1e-58
Identities = 151/469 (32%), Positives = 239/469 (50%), Gaps = 16/469 (3%)
Query: 140 RIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLC 199
RIR S+LRQD+ ++ L S++S + + + V+ + V
Sbjct: 160 RIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYG 219
Query: 200 TAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREME-SYSLAGKQAEEILKSVRTI 258
+ +LTL MPF++ + N + + +RE++ + + AG+ E + ++T+
Sbjct: 220 FMLSISPRLTLLSLLHMPFTIAAE-KVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTV 278
Query: 259 VAFGGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVND 318
+FG E EV RY+ LE + +R L L VL + + S G + + +
Sbjct: 279 RSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDG 338
Query: 319 FDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKID 378
T +L + +Y Y+ Q++ + + +F ++R+P +
Sbjct: 339 ELTQGSLLSF---MIYQESVGSYV--QTLVYIYGDM---LSNVGAAEKVFSYMDRQPNLP 390
Query: 379 SLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTV 438
S L P + G + +DV F YP+RP+ VLKG + ++PGE ALVG +G GKSTV
Sbjct: 391 S--PGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV 448
Query: 439 LQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEAT 498
LLQ LY P G V +L S + VGQEPVLF G++ +NIA G
Sbjct: 449 AALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE 508
Query: 499 REEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 558
+++ A+ A+A DFI + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDE
Sbjct: 509 DDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDE 568
Query: 559 ATSALDPHSERQVQAALDRASVG-RTTITVSHRLSTIVNADRIICMDQG 606
ATSALD E QA D S G RT + ++HRL T+ A +I+ + +G
Sbjct: 569 ATSALDVQCE---QALQDWNSCGDRTVLVIAHRLQTVQRAHQILVLQEG 614
Score = 158 bits (383), Expect = 1e-37
Identities = 139/486 (28%), Positives = 238/486 (48%), Gaps = 26/486 (5%)
Query: 727 WQLLKLNAPEWPLITVGSIAAFLQGACFPVFALLFGFSSGIFILDNRDDIIYLADLYSVL 786
W+LLKL+ P+ PL+ +AAF + L SG I D A ++
Sbjct: 75 WRLLKLSRPDLPLL----VAAFFFLVLAVLGETLIPHYSGRVIDILGGDFDPHAFASAIF 130
Query: 787 FVVIAAV-AGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICAR 845
F+ + + + +S + FT ++ R+R Q F+SLL+Q++GFF +ET T G + +R
Sbjct: 131 FMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFF-QETKT-GELNSR 188
Query: 846 LSGDTAEVQGATGLRIGLILQGISSVV--VGFLLAISYNWKLTLVATVFLPLMVGSIWLE 903
LS DT + L ++L+ + VV GF+L+IS +LTL++ + +P + + +
Sbjct: 189 LSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISP--RLTLLSLLHMPFTIAAEKVY 246
Query: 904 GIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVAYKT 963
Q+ + ++A+ A + EAV ++TV+S G E + ++++AL+ C + ++
Sbjct: 247 NTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQ-CRQLYWRR 305
Query: 964 RWRGLVYGLGVYIPFMAYCSATVY-GAVLVAYGEMEYKLVL---LVNEAIMYGAYMLGQS 1019
+Y L + + + G + GE+ +L + E++ G+Y+
Sbjct: 306 DLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESV--GSYVQTLV 363
Query: 1020 LVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQ 1079
+Y L+ A ++ S + RQP + + + G +DV F YP RP +
Sbjct: 364 YIYGDMLSNVGAA-EKVFSYMDRQPNLPSPGTLAPT---TLQGVVKFQDVSFAYPNRPDR 419
Query: 1080 RVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRL 1139
VLKG+ + G+ ALVG +G GKST+ L Q Y P G + LD + I S L
Sbjct: 420 PVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPI-SQYEHCYL 478
Query: 1140 RRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAV-TEA 1198
Q+ V QEPVL S+ NIAYG + +++AAA+AA+ FI + + T+
Sbjct: 479 HSQVVSVGQEPVLFSGSVRNNIAYG--LQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDV 536
Query: 1199 LEKAAK 1204
EK ++
Sbjct: 537 GEKGSQ 542
>BT009906-1|AAP88908.1| 686|Homo sapiens transporter 2, ATP-binding
cassette, sub-family B (MDR/TAP) protein.
Length = 686
Score = 227 bits (556), Expect = 1e-58
Identities = 148/468 (31%), Positives = 238/468 (50%), Gaps = 14/468 (2%)
Query: 140 RIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLC 199
RIR S+LRQD+ ++ L S++S + + + V+ + V
Sbjct: 224 RIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYG 283
Query: 200 TAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREME-SYSLAGKQAEEILKSVRTI 258
+ +LTL MPF++ + N + + +RE++ + + AG+ E + ++T+
Sbjct: 284 FMLSISPRLTLLSLLHMPFTIAAE-KVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTV 342
Query: 259 VAFGGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVND 318
+FG E EV RY+ LE + +R L L VL + + S G + + +
Sbjct: 343 RSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDG 402
Query: 319 FDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKID 378
T +L + +Y Y+ Q++ + + +F ++R+P +
Sbjct: 403 ELTQGSLLSF---MIYQESVGSYV--QTLVYIYGDM---LSNVGAAEKVFSYMDRQPNLP 454
Query: 379 SLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTV 438
S L P + G + +DV F YP+RP+ VLKG + ++PGE ALVG +G GKSTV
Sbjct: 455 S--PGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV 512
Query: 439 LQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEAT 498
LLQ LY P G V +L S + VGQEPVLF G++ +NIA G
Sbjct: 513 AALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE 572
Query: 499 REEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 558
+++ A+ A+A DFI + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDE
Sbjct: 573 DDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDE 632
Query: 559 ATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQG 606
ATSALD E+ +Q R RT + ++HRL T+ A +I+ + +G
Sbjct: 633 ATSALDVQCEQALQDWNSRGD--RTVLVIAHRLQTVQRAHQILVLQEG 678
Score = 158 bits (383), Expect = 1e-37
Identities = 139/486 (28%), Positives = 238/486 (48%), Gaps = 26/486 (5%)
Query: 727 WQLLKLNAPEWPLITVGSIAAFLQGACFPVFALLFGFSSGIFILDNRDDIIYLADLYSVL 786
W+LLKL+ P+ PL+ +AAF + L SG I D A ++
Sbjct: 139 WRLLKLSRPDLPLL----VAAFFFLVLAVLGETLIPHYSGRVIDILGGDFDPHAFASAIF 194
Query: 787 FVVIAAV-AGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICAR 845
F+ + + + +S + FT ++ R+R Q F+SLL+Q++GFF +ET T G + +R
Sbjct: 195 FMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFF-QETKT-GELNSR 252
Query: 846 LSGDTAEVQGATGLRIGLILQGISSVV--VGFLLAISYNWKLTLVATVFLPLMVGSIWLE 903
LS DT + L ++L+ + VV GF+L+IS +LTL++ + +P + + +
Sbjct: 253 LSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISP--RLTLLSLLHMPFTIAAEKVY 310
Query: 904 GIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVAYKT 963
Q+ + ++A+ A + EAV ++TV+S G E + ++++AL+ C + ++
Sbjct: 311 NTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQ-CRQLYWRR 369
Query: 964 RWRGLVYGLGVYIPFMAYCSATVY-GAVLVAYGEMEYKLVL---LVNEAIMYGAYMLGQS 1019
+Y L + + + G + GE+ +L + E++ G+Y+
Sbjct: 370 DLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESV--GSYVQTLV 427
Query: 1020 LVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQ 1079
+Y L+ A ++ S + RQP + + + G +DV F YP RP +
Sbjct: 428 YIYGDMLSNVGAA-EKVFSYMDRQPNLPSPGTLAPT---TLQGVVKFQDVSFAYPNRPDR 483
Query: 1080 RVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRL 1139
VLKG+ + G+ ALVG +G GKST+ L Q Y P G + LD + I S L
Sbjct: 484 PVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPI-SQYEHCYL 542
Query: 1140 RRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAV-TEA 1198
Q+ V QEPVL S+ NIAYG + +++AAA+AA+ FI + + T+
Sbjct: 543 HSQVVSVGQEPVLFSGSVRNNIAYG--LQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDV 600
Query: 1199 LEKAAK 1204
EK ++
Sbjct: 601 GEKGSQ 606
>AL935043-2|CAI18622.1| 686|Homo sapiens transporter 2, ATP-binding
cassette, sub-family Bta protein.
Length = 686
Score = 227 bits (556), Expect = 1e-58
Identities = 148/468 (31%), Positives = 238/468 (50%), Gaps = 14/468 (2%)
Query: 140 RIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLC 199
RIR S+LRQD+ ++ L S++S + + + V+ + V
Sbjct: 224 RIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYG 283
Query: 200 TAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREME-SYSLAGKQAEEILKSVRTI 258
+ +LTL MPF++ + N + + +RE++ + + AG+ E + ++T+
Sbjct: 284 FMLSISPRLTLLSLLHMPFTIAAE-KVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTV 342
Query: 259 VAFGGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVND 318
+FG E EV RY+ LE + +R L L VL + + S G + + +
Sbjct: 343 RSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDG 402
Query: 319 FDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKID 378
T +L + +Y Y+ Q++ + + +F ++R+P +
Sbjct: 403 ELTQGSLLSF---MIYQESVGSYV--QTLVYIYGDM---LSNVGAAEKVFSYMDRQPNLP 454
Query: 379 SLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTV 438
S L P + G + +DV F YP+RP+ VLKG + ++PGE ALVG +G GKSTV
Sbjct: 455 S--PGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV 512
Query: 439 LQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEAT 498
LLQ LY P G V +L S + VGQEPVLF G++ +NIA G
Sbjct: 513 AALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE 572
Query: 499 REEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 558
+++ A+ A+A DFI + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDE
Sbjct: 573 DDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDE 632
Query: 559 ATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQG 606
ATSALD E+ +Q R RT + ++HRL T+ A +I+ + +G
Sbjct: 633 ATSALDVQCEQALQDWNSRGD--RTVLVIAHRLQTVQRAHQILVLQEG 678
Score = 158 bits (383), Expect = 1e-37
Identities = 139/486 (28%), Positives = 238/486 (48%), Gaps = 26/486 (5%)
Query: 727 WQLLKLNAPEWPLITVGSIAAFLQGACFPVFALLFGFSSGIFILDNRDDIIYLADLYSVL 786
W+LLKL+ P+ PL+ +AAF + L SG I D A ++
Sbjct: 139 WRLLKLSRPDLPLL----VAAFFFLVLAVLGETLIPHYSGRVIDILGGDFDPHAFASAIF 194
Query: 787 FVVIAAV-AGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICAR 845
F+ + + + +S + FT ++ R+R Q F+SLL+Q++GFF +ET T G + +R
Sbjct: 195 FMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFF-QETKT-GELNSR 252
Query: 846 LSGDTAEVQGATGLRIGLILQGISSVV--VGFLLAISYNWKLTLVATVFLPLMVGSIWLE 903
LS DT + L ++L+ + VV GF+L+IS +LTL++ + +P + + +
Sbjct: 253 LSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISP--RLTLLSLLHMPFTIAAEKVY 310
Query: 904 GIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVAYKT 963
Q+ + ++A+ A + EAV ++TV+S G E + ++++AL+ C + ++
Sbjct: 311 NTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQ-CRQLYWRR 369
Query: 964 RWRGLVYGLGVYIPFMAYCSATVY-GAVLVAYGEMEYKLVL---LVNEAIMYGAYMLGQS 1019
+Y L + + + G + GE+ +L + E++ G+Y+
Sbjct: 370 DLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESV--GSYVQTLV 427
Query: 1020 LVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQ 1079
+Y L+ A ++ S + RQP + + + G +DV F YP RP +
Sbjct: 428 YIYGDMLSNVGAA-EKVFSYMDRQPNLPSPGTLAPT---TLQGVVKFQDVSFAYPNRPDR 483
Query: 1080 RVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRL 1139
VLKG+ + G+ ALVG +G GKST+ L Q Y P G + LD + I S L
Sbjct: 484 PVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPI-SQYEHCYL 542
Query: 1140 RRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAV-TEA 1198
Q+ V QEPVL S+ NIAYG + +++AAA+AA+ FI + + T+
Sbjct: 543 HSQVVSVGQEPVLFSGSVRNNIAYG--LQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDV 600
Query: 1199 LEKAAK 1204
EK ++
Sbjct: 601 GEKGSQ 606
>AL671681-8|CAI17711.1| 686|Homo sapiens transporter 2, ATP-binding
cassette, sub-family Bta 9 (pseudogene) protein.
Length = 686
Score = 227 bits (556), Expect = 1e-58
Identities = 148/468 (31%), Positives = 238/468 (50%), Gaps = 14/468 (2%)
Query: 140 RIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLC 199
RIR S+LRQD+ ++ L S++S + + + V+ + V
Sbjct: 224 RIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYG 283
Query: 200 TAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREME-SYSLAGKQAEEILKSVRTI 258
+ +LTL MPF++ + N + + +RE++ + + AG+ E + ++T+
Sbjct: 284 FMLSISPRLTLLSLLHMPFTIAAE-KVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTV 342
Query: 259 VAFGGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVND 318
+FG E EV RY+ LE + +R L L VL + + S G + + +
Sbjct: 343 RSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDG 402
Query: 319 FDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKID 378
T +L + +Y Y+ Q++ + + +F ++R+P +
Sbjct: 403 ELTQGSLLSF---MIYQESVGSYV--QTLVYIYGDM---LSNVGAAEKVFSYMDRQPNLP 454
Query: 379 SLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTV 438
S L P + G + +DV F YP+RP+ VLKG + ++PGE ALVG +G GKSTV
Sbjct: 455 S--PGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV 512
Query: 439 LQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEAT 498
LLQ LY P G V +L S + VGQEPVLF G++ +NIA G
Sbjct: 513 AALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE 572
Query: 499 REEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 558
+++ A+ A+A DFI + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDE
Sbjct: 573 DDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDE 632
Query: 559 ATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQG 606
ATSALD E+ +Q R RT + ++HRL T+ A +I+ + +G
Sbjct: 633 ATSALDVQCEQALQDWNSRGD--RTVLVIAHRLQTVQRAHQILVLQEG 678
Score = 158 bits (383), Expect = 1e-37
Identities = 139/486 (28%), Positives = 238/486 (48%), Gaps = 26/486 (5%)
Query: 727 WQLLKLNAPEWPLITVGSIAAFLQGACFPVFALLFGFSSGIFILDNRDDIIYLADLYSVL 786
W+LLKL+ P+ PL+ +AAF + L SG I D A ++
Sbjct: 139 WRLLKLSRPDLPLL----VAAFFFLVLAVLGETLIPHYSGRVIDILGGDFDPHAFASAIF 194
Query: 787 FVVIAAV-AGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICAR 845
F+ + + + +S + FT ++ R+R Q F+SLL+Q++GFF +ET T G + +R
Sbjct: 195 FMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFF-QETKT-GELNSR 252
Query: 846 LSGDTAEVQGATGLRIGLILQGISSVV--VGFLLAISYNWKLTLVATVFLPLMVGSIWLE 903
LS DT + L ++L+ + VV GF+L+IS +LTL++ + +P + + +
Sbjct: 253 LSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISP--RLTLLSLLHMPFTIAAEKVY 310
Query: 904 GIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVAYKT 963
Q+ + ++A+ A + EAV ++TV+S G E + ++++AL+ C + ++
Sbjct: 311 NTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQ-CRQLYWRR 369
Query: 964 RWRGLVYGLGVYIPFMAYCSATVY-GAVLVAYGEMEYKLVL---LVNEAIMYGAYMLGQS 1019
+Y L + + + G + GE+ +L + E++ G+Y+
Sbjct: 370 DLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESV--GSYVQTLV 427
Query: 1020 LVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQ 1079
+Y L+ A ++ S + RQP + + + G +DV F YP RP +
Sbjct: 428 YIYGDMLSNVGAA-EKVFSYMDRQPNLPSPGTLAPT---TLQGVVKFQDVSFAYPNRPDR 483
Query: 1080 RVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRL 1139
VLKG+ + G+ ALVG +G GKST+ L Q Y P G + LD + I S L
Sbjct: 484 PVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPI-SQYEHCYL 542
Query: 1140 RRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAV-TEA 1198
Q+ V QEPVL S+ NIAYG + +++AAA+AA+ FI + + T+
Sbjct: 543 HSQVVSVGQEPVLFSGSVRNNIAYG--LQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDV 600
Query: 1199 LEKAAK 1204
EK ++
Sbjct: 601 GEKGSQ 606
>AL669918-4|CAI18137.1| 686|Homo sapiens transporter 2, ATP-binding
cassette, sub-family Bunit 11 protein.
Length = 686
Score = 227 bits (556), Expect = 1e-58
Identities = 148/468 (31%), Positives = 238/468 (50%), Gaps = 14/468 (2%)
Query: 140 RIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLC 199
RIR S+LRQD+ ++ L S++S + + + V+ + V
Sbjct: 224 RIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYG 283
Query: 200 TAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREME-SYSLAGKQAEEILKSVRTI 258
+ +LTL MPF++ + N + + +RE++ + + AG+ E + ++T+
Sbjct: 284 FMLSISPRLTLLSLLHMPFTIAAE-KVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTV 342
Query: 259 VAFGGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVND 318
+FG E EV RY+ LE + +R L L VL + + S G + + +
Sbjct: 343 RSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDG 402
Query: 319 FDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKID 378
T +L + +Y Y+ Q++ + + +F ++R+P +
Sbjct: 403 ELTQGSLLSF---MIYQESVGSYV--QTLVYIYGDM---LSNVGAAEKVFSYMDRQPNLP 454
Query: 379 SLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTV 438
S L P + G + +DV F YP+RP+ VLKG + ++PGE ALVG +G GKSTV
Sbjct: 455 S--PGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV 512
Query: 439 LQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEAT 498
LLQ LY P G V +L S + VGQEPVLF G++ +NIA G
Sbjct: 513 AALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE 572
Query: 499 REEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 558
+++ A+ A+A DFI + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDE
Sbjct: 573 DDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDE 632
Query: 559 ATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQG 606
ATSALD E+ +Q R RT + ++HRL T+ A +I+ + +G
Sbjct: 633 ATSALDVQCEQALQDWNSRGD--RTVLVIAHRLQTVQRAHQILVLQEG 678
Score = 158 bits (383), Expect = 1e-37
Identities = 139/486 (28%), Positives = 238/486 (48%), Gaps = 26/486 (5%)
Query: 727 WQLLKLNAPEWPLITVGSIAAFLQGACFPVFALLFGFSSGIFILDNRDDIIYLADLYSVL 786
W+LLKL+ P+ PL+ +AAF + L SG I D A ++
Sbjct: 139 WRLLKLSRPDLPLL----VAAFFFLVLAVLGETLIPHYSGRVIDILGGDFDPHAFASAIF 194
Query: 787 FVVIAAV-AGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICAR 845
F+ + + + +S + FT ++ R+R Q F+SLL+Q++GFF +ET T G + +R
Sbjct: 195 FMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFF-QETKT-GELNSR 252
Query: 846 LSGDTAEVQGATGLRIGLILQGISSVV--VGFLLAISYNWKLTLVATVFLPLMVGSIWLE 903
LS DT + L ++L+ + VV GF+L+IS +LTL++ + +P + + +
Sbjct: 253 LSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISP--RLTLLSLLHMPFTIAAEKVY 310
Query: 904 GIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVAYKT 963
Q+ + ++A+ A + EAV ++TV+S G E + ++++AL+ C + ++
Sbjct: 311 NTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQ-CRQLYWRR 369
Query: 964 RWRGLVYGLGVYIPFMAYCSATVY-GAVLVAYGEMEYKLVL---LVNEAIMYGAYMLGQS 1019
+Y L + + + G + GE+ +L + E++ G+Y+
Sbjct: 370 DLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESV--GSYVQTLV 427
Query: 1020 LVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQ 1079
+Y L+ A ++ S + RQP + + + G +DV F YP RP +
Sbjct: 428 YIYGDMLSNVGAA-EKVFSYMDRQPNLPSPGTLAPT---TLQGVVKFQDVSFAYPNRPDR 483
Query: 1080 RVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRL 1139
VLKG+ + G+ ALVG +G GKST+ L Q Y P G + LD + I S L
Sbjct: 484 PVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPI-SQYEHCYL 542
Query: 1140 RRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAV-TEA 1198
Q+ V QEPVL S+ NIAYG + +++AAA+AA+ FI + + T+
Sbjct: 543 HSQVVSVGQEPVLFSGSVRNNIAYG--LQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDV 600
Query: 1199 LEKAAK 1204
EK ++
Sbjct: 601 GEKGSQ 606
>M74447-1|AAA59841.1| 703|Homo sapiens PSF-2 protein.
Length = 703
Score = 227 bits (555), Expect = 2e-58
Identities = 151/490 (30%), Positives = 246/490 (50%), Gaps = 17/490 (3%)
Query: 140 RIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLC 199
RIR S+LRQD+ ++ L S++S + + + V+ + V
Sbjct: 224 RIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYG 283
Query: 200 TAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREME-SYSLAGKQAEEILKSVRTI 258
+ +LTL MPF++ + N + + +RE++ + + AG+ E + ++T+
Sbjct: 284 FMLSISPRLTLLSLLHMPFTIAAE-KVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTV 342
Query: 259 VAFGGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVND 318
+FG E EV RY+ LE + +R L L VL + + S G + + +
Sbjct: 343 RSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLIRRVLHLGVQMLMLSCGLQQMQDG 402
Query: 319 FDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKID 378
T +L + +Y Y+ Q++ + + +F ++R+P +
Sbjct: 403 ELTQGSLLSF---MIYQESVGSYV--QTLVYIYGDM---LSNVGAAEKVFSYMDRQPNLP 454
Query: 379 SLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTV 438
S L P + G + +DV F YP+RP+ VLKG + ++PGE ALVG +G GKSTV
Sbjct: 455 S--PGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV 512
Query: 439 LQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEAT 498
LLQ LY P G V +L S + VGQEPVLF G++ +NIA G
Sbjct: 513 AALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE 572
Query: 499 REEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 558
+++ A+ A+A DFI + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDE
Sbjct: 573 DDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDE 632
Query: 559 ATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLM 618
ATSALD E+ +Q R RT + ++HRL + A +I+ + +G + + L
Sbjct: 633 ATSALDVQCEQALQDWNSRGD--RTVLVIAHRLQAVQRAHQILVLQEGKLQKLA---QLQ 687
Query: 619 KAKGFYHKLV 628
+ + Y +LV
Sbjct: 688 EGQDLYSRLV 697
Score = 157 bits (382), Expect = 2e-37
Identities = 138/485 (28%), Positives = 233/485 (48%), Gaps = 24/485 (4%)
Query: 727 WQLLKLNAPEWPLITVGSIAAFLQGACFPVFALLFGFSSGIFILDNRDDIIYLADLYSVL 786
W+LLKL+ P+ PL+ +AAF + L SG I D A ++
Sbjct: 139 WRLLKLSRPDLPLL----VAAFFFLVLAVLGETLIPHYSGRVIDILGGDFDPHAFASAIF 194
Query: 787 FVVIAAV-AGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICAR 845
F+ + + + +S + FT ++ R+R Q F+SLL+Q++GFF +ET T G + +R
Sbjct: 195 FMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFF-QETKT-GELNSR 252
Query: 846 LSGDTAEVQGATGLRIGLILQGISSVV--VGFLLAISYNWKLTLVATVFLPLMVGSIWLE 903
LS DT + L ++L+ + VV GF+L+IS +LTL++ + +P + + +
Sbjct: 253 LSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISP--RLTLLSLLHMPFTIAAEKVY 310
Query: 904 GIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVAYKT 963
Q+ + ++A+ A + EAV ++TV+S G E + ++++AL+ +
Sbjct: 311 NTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQCRQLYWRRD 370
Query: 964 RWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEYKLVL---LVNEAIMYGAYMLGQSL 1020
R L + + G + GE+ +L + E++ G+Y+
Sbjct: 371 LERALYLLIRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESV--GSYVQTLVY 428
Query: 1021 VYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQR 1080
+Y L+ A ++ S + RQP + + + G +DV F YP RP +
Sbjct: 429 IYGDMLSNVGAA-EKVFSYMDRQPNLPSPGTLAPT---TLQGVVKFQDVSFAYPNRPDRP 484
Query: 1081 VLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLR 1140
VLKG+ + G+ ALVG +G GKST+ L Q Y P G + LD + I S L
Sbjct: 485 VLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPI-SQYEHCYLH 543
Query: 1141 RQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAV-TEAL 1199
Q+ V QEPVL S+ NIAYG + +++AAA+AA+ FI + + T+
Sbjct: 544 SQVVSVGQEPVLFSGSVRNNIAYG--LQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVG 601
Query: 1200 EKAAK 1204
EK ++
Sbjct: 602 EKGSQ 606
>Z22935-1|CAA80522.1| 703|Homo sapiens TAP2B protein.
Length = 703
Score = 227 bits (554), Expect = 3e-58
Identities = 151/490 (30%), Positives = 246/490 (50%), Gaps = 17/490 (3%)
Query: 140 RIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLC 199
RIR S+LRQD+ ++ L S++S + + + V+ + V
Sbjct: 224 RIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYG 283
Query: 200 TAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREME-SYSLAGKQAEEILKSVRTI 258
+ +LTL MPF++ + N + + +RE++ + + AG+ E + ++T+
Sbjct: 284 FMLSISPRLTLLSLLHMPFTIAAE-KVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTV 342
Query: 259 VAFGGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVND 318
+FG E EV RY+ LE + +R L L VL + + S G + + +
Sbjct: 343 RSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDG 402
Query: 319 FDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKID 378
T +L + +Y Y+ Q++ + + +F ++R+P +
Sbjct: 403 ELTQGSLLSF---MIYQESVGSYV--QTLVYIYGDM---LSNVGAAEKVFSYMDRQPNLP 454
Query: 379 SLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTV 438
S L P + G + +DV F YP+RP+ VLKG + ++PGE ALVG +G GKSTV
Sbjct: 455 S--PGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV 512
Query: 439 LQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEAT 498
LLQ LY P G V +L S + VGQEPVLF G++ +NIA G
Sbjct: 513 AALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE 572
Query: 499 REEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 558
+++ A+ A+A DFI + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDE
Sbjct: 573 DDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDE 632
Query: 559 ATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLM 618
ATSALD E+ +Q R RT + ++HRL + A +I+ + +G + + L
Sbjct: 633 ATSALDVQCEQALQDWNSRGD--RTVLVIAHRLQAVQRAHQILVLQEGKLQKLA---QLQ 687
Query: 619 KAKGFYHKLV 628
+ + Y +LV
Sbjct: 688 EGQDLYSRLV 697
Score = 158 bits (383), Expect = 1e-37
Identities = 139/486 (28%), Positives = 238/486 (48%), Gaps = 26/486 (5%)
Query: 727 WQLLKLNAPEWPLITVGSIAAFLQGACFPVFALLFGFSSGIFILDNRDDIIYLADLYSVL 786
W+LLKL+ P+ PL+ +AAF + L SG I D A ++
Sbjct: 139 WRLLKLSRPDLPLL----VAAFFFLVLAVLGETLIPHYSGRVIDILGGDFDPHAFASAIF 194
Query: 787 FVVIAAV-AGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICAR 845
F+ + + + +S + FT ++ R+R Q F+SLL+Q++GFF +ET T G + +R
Sbjct: 195 FMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFF-QETKT-GELNSR 252
Query: 846 LSGDTAEVQGATGLRIGLILQGISSVV--VGFLLAISYNWKLTLVATVFLPLMVGSIWLE 903
LS DT + L ++L+ + VV GF+L+IS +LTL++ + +P + + +
Sbjct: 253 LSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISP--RLTLLSLLHMPFTIAAEKVY 310
Query: 904 GIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVAYKT 963
Q+ + ++A+ A + EAV ++TV+S G E + ++++AL+ C + ++
Sbjct: 311 NTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQ-CRQLYWRR 369
Query: 964 RWRGLVYGLGVYIPFMAYCSATVY-GAVLVAYGEMEYKLVL---LVNEAIMYGAYMLGQS 1019
+Y L + + + G + GE+ +L + E++ G+Y+
Sbjct: 370 DLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESV--GSYVQTLV 427
Query: 1020 LVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQ 1079
+Y L+ A ++ S + RQP + + + G +DV F YP RP +
Sbjct: 428 YIYGDMLSNVGAA-EKVFSYMDRQPNLPSPGTLAPT---TLQGVVKFQDVSFAYPNRPDR 483
Query: 1080 RVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRL 1139
VLKG+ + G+ ALVG +G GKST+ L Q Y P G + LD + I S L
Sbjct: 484 PVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPI-SQYEHCYL 542
Query: 1140 RRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAV-TEA 1198
Q+ V QEPVL S+ NIAYG + +++AAA+AA+ FI + + T+
Sbjct: 543 HSQVVSVGQEPVLFSGSVRNNIAYG--LQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDV 600
Query: 1199 LEKAAK 1204
EK ++
Sbjct: 601 GEKGSQ 606
>BX682530-4|CAI41935.1| 703|Homo sapiens transporter 2 ATP-binding
cassette sub-family B (MDR/TAP) protein.
Length = 703
Score = 227 bits (554), Expect = 3e-58
Identities = 151/490 (30%), Positives = 246/490 (50%), Gaps = 17/490 (3%)
Query: 140 RIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLC 199
RIR S+LRQD+ ++ L S++S + + + V+ + V
Sbjct: 224 RIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYG 283
Query: 200 TAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREME-SYSLAGKQAEEILKSVRTI 258
+ +LTL MPF++ + N + + +RE++ + + AG+ E + ++T+
Sbjct: 284 FMLSISPRLTLLSLLHMPFTIAAE-KVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTV 342
Query: 259 VAFGGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVND 318
+FG E EV RY+ LE + +R L L VL + + S G + + +
Sbjct: 343 RSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDG 402
Query: 319 FDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKID 378
T +L + +Y Y+ Q++ + + +F ++R+P +
Sbjct: 403 ELTQGSLLSF---MIYQESVGSYV--QTLVYIYGDM---LSNVGAAEKVFSYMDRQPNLP 454
Query: 379 SLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTV 438
S L P + G + +DV F YP+RP+ VLKG + ++PGE ALVG +G GKSTV
Sbjct: 455 S--PGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV 512
Query: 439 LQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEAT 498
LLQ LY P G V +L S + VGQEPVLF G++ +NIA G
Sbjct: 513 AALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE 572
Query: 499 REEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 558
+++ A+ A+A DFI + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDE
Sbjct: 573 DDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDE 632
Query: 559 ATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLM 618
ATSALD E+ +Q R RT + ++HRL + A +I+ + +G + + L
Sbjct: 633 ATSALDVQCEQALQDWNSRGD--RTVLVIAHRLQAVQRAHQILVLQEGKLQKLA---QLQ 687
Query: 619 KAKGFYHKLV 628
+ + Y +LV
Sbjct: 688 EGQDLYSRLV 697
Score = 158 bits (383), Expect = 1e-37
Identities = 139/486 (28%), Positives = 238/486 (48%), Gaps = 26/486 (5%)
Query: 727 WQLLKLNAPEWPLITVGSIAAFLQGACFPVFALLFGFSSGIFILDNRDDIIYLADLYSVL 786
W+LLKL+ P+ PL+ +AAF + L SG I D A ++
Sbjct: 139 WRLLKLSRPDLPLL----VAAFFFLVLAVLGETLIPHYSGRVIDILGGDFDPHAFASAIF 194
Query: 787 FVVIAAV-AGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICAR 845
F+ + + + +S + FT ++ R+R Q F+SLL+Q++GFF +ET T G + +R
Sbjct: 195 FMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFF-QETKT-GELNSR 252
Query: 846 LSGDTAEVQGATGLRIGLILQGISSVV--VGFLLAISYNWKLTLVATVFLPLMVGSIWLE 903
LS DT + L ++L+ + VV GF+L+IS +LTL++ + +P + + +
Sbjct: 253 LSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISP--RLTLLSLLHMPFTIAAEKVY 310
Query: 904 GIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVAYKT 963
Q+ + ++A+ A + EAV ++TV+S G E + ++++AL+ C + ++
Sbjct: 311 NTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQ-CRQLYWRR 369
Query: 964 RWRGLVYGLGVYIPFMAYCSATVY-GAVLVAYGEMEYKLVL---LVNEAIMYGAYMLGQS 1019
+Y L + + + G + GE+ +L + E++ G+Y+
Sbjct: 370 DLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESV--GSYVQTLV 427
Query: 1020 LVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQ 1079
+Y L+ A ++ S + RQP + + + G +DV F YP RP +
Sbjct: 428 YIYGDMLSNVGAA-EKVFSYMDRQPNLPSPGTLAPT---TLQGVVKFQDVSFAYPNRPDR 483
Query: 1080 RVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRL 1139
VLKG+ + G+ ALVG +G GKST+ L Q Y P G + LD + I S L
Sbjct: 484 PVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPI-SQYEHCYL 542
Query: 1140 RRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAV-TEA 1198
Q+ V QEPVL S+ NIAYG + +++AAA+AA+ FI + + T+
Sbjct: 543 HSQVVSVGQEPVLFSGSVRNNIAYG--LQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDV 600
Query: 1199 LEKAAK 1204
EK ++
Sbjct: 601 GEKGSQ 606
>AK222823-1|BAD96543.1| 703|Homo sapiens transporter 2, ATP-binding
cassette, sub-family B isoform 1 variant protein.
Length = 703
Score = 227 bits (554), Expect = 3e-58
Identities = 151/490 (30%), Positives = 246/490 (50%), Gaps = 17/490 (3%)
Query: 140 RIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLC 199
RIR S+LRQD+ ++ L S++S + + + V+ + V
Sbjct: 224 RIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYG 283
Query: 200 TAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREME-SYSLAGKQAEEILKSVRTI 258
+ +LTL MPF++ + N + + +RE++ + + AG+ E + ++T+
Sbjct: 284 FMLSISPRLTLLSLLHMPFTIAAE-KVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTV 342
Query: 259 VAFGGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVND 318
+FG E EV RY+ LE + +R L L VL + + S G + + +
Sbjct: 343 RSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDG 402
Query: 319 FDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKID 378
T +L + +Y Y+ Q++ + + +F ++R+P +
Sbjct: 403 ELTQGSLLSF---MIYQESVGSYV--QTLVYIYGDM---LSNVGAAEKVFSYMDRQPNLP 454
Query: 379 SLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTV 438
S L P + G + +DV F YP+RP+ VLKG + ++PGE ALVG +G GKSTV
Sbjct: 455 S--PGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV 512
Query: 439 LQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEAT 498
LLQ LY P G V +L S + VGQEPVLF G++ +NIA G
Sbjct: 513 AALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE 572
Query: 499 REEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 558
+++ A+ A+A DFI + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDE
Sbjct: 573 DDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDE 632
Query: 559 ATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLM 618
ATSALD E+ +Q R RT + ++HRL + A +I+ + +G + + L
Sbjct: 633 ATSALDVQCEQALQDWNSRGD--RTVLVIAHRLQAVQRAHQILVLQEGKLQKLA---QLQ 687
Query: 619 KAKGFYHKLV 628
+ + Y +LV
Sbjct: 688 EGQDLYSRLV 697
Score = 158 bits (383), Expect = 1e-37
Identities = 139/486 (28%), Positives = 238/486 (48%), Gaps = 26/486 (5%)
Query: 727 WQLLKLNAPEWPLITVGSIAAFLQGACFPVFALLFGFSSGIFILDNRDDIIYLADLYSVL 786
W+LLKL+ P+ PL+ +AAF + L SG I D A ++
Sbjct: 139 WRLLKLSRPDLPLL----VAAFFFLVLAVLGETLIPHYSGRVIDILGGDFDPHAFASAIF 194
Query: 787 FVVIAAV-AGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICAR 845
F+ + + + +S + FT ++ R+R Q F+SLL+Q++GFF +ET T G + +R
Sbjct: 195 FMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFF-QETKT-GELNSR 252
Query: 846 LSGDTAEVQGATGLRIGLILQGISSVV--VGFLLAISYNWKLTLVATVFLPLMVGSIWLE 903
LS DT + L ++L+ + VV GF+L+IS +LTL++ + +P + + +
Sbjct: 253 LSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISP--RLTLLSLLHMPFTIAAEKVY 310
Query: 904 GIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVAYKT 963
Q+ + ++A+ A + EAV ++TV+S G E + ++++AL+ C + ++
Sbjct: 311 NTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQ-CRQLYWRR 369
Query: 964 RWRGLVYGLGVYIPFMAYCSATVY-GAVLVAYGEMEYKLVL---LVNEAIMYGAYMLGQS 1019
+Y L + + + G + GE+ +L + E++ G+Y+
Sbjct: 370 DLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESV--GSYVQTLV 427
Query: 1020 LVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQ 1079
+Y L+ A ++ S + RQP + + + G +DV F YP RP +
Sbjct: 428 YIYGDMLSNVGAA-EKVFSYMDRQPNLPSPGTLAPT---TLQGVVKFQDVSFAYPNRPDR 483
Query: 1080 RVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRL 1139
VLKG+ + G+ ALVG +G GKST+ L Q Y P G + LD + I S L
Sbjct: 484 PVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPI-SQYEHCYL 542
Query: 1140 RRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAV-TEA 1198
Q+ V QEPVL S+ NIAYG + +++AAA+AA+ FI + + T+
Sbjct: 543 HSQVVSVGQEPVLFSGSVRNNIAYG--LQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDV 600
Query: 1199 LEKAAK 1204
EK ++
Sbjct: 601 GEKGSQ 606
>AF100418-1|AAD23381.1| 483|Homo sapiens TAP2 protein protein.
Length = 483
Score = 227 bits (554), Expect = 3e-58
Identities = 148/468 (31%), Positives = 238/468 (50%), Gaps = 14/468 (2%)
Query: 140 RIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLC 199
RIR S+LRQD+ ++ L S++S + + + V+ + V
Sbjct: 21 RIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYG 80
Query: 200 TAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREME-SYSLAGKQAEEILKSVRTI 258
+ +LTL MPF++ + N + + +RE++ + + AG+ E + ++T+
Sbjct: 81 FMLSISPRLTLLSLLHMPFTIAAE-KVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTV 139
Query: 259 VAFGGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVND 318
+FG E EV RY+ LE + +R L L VL + + S G + + +
Sbjct: 140 RSFGAEEHEVCRYKEALEQCRQLYWRRDLERTLYLLVRRVLHLGVQMLMLSCGLQQMQDG 199
Query: 319 FDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKID 378
T +L + +Y Y+ Q++ + + +F ++R+P +
Sbjct: 200 ELTQGSLLSF---MIYQESVGSYV--QTLVYIYGDM---LSNVGAAEKVFSYMDRQPNLP 251
Query: 379 SLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTV 438
S L P + G + +DV F YP+RP+ VLKG + ++PGE ALVG +G GKSTV
Sbjct: 252 S--PGTLAPTTLQGIVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV 309
Query: 439 LQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEAT 498
LLQ LY P G V +L S + VGQEPVLF G++ +NIA G
Sbjct: 310 AALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE 369
Query: 499 REEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 558
+++ A+ A+A DFI + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDE
Sbjct: 370 DDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDE 429
Query: 559 ATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQG 606
ATSALD E+ +Q R RT + ++HRL T+ A +I+ + +G
Sbjct: 430 ATSALDVQCEQALQDWNSRGD--RTVLVIAHRLQTVQRAHQILVLQEG 475
Score = 149 bits (360), Expect = 8e-35
Identities = 120/407 (29%), Positives = 205/407 (50%), Gaps = 21/407 (5%)
Query: 805 FTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLI 864
FT ++ R+R Q F+SLL+Q++GFF +ET T G + +RLS DT + L ++
Sbjct: 11 FTYTMSRINLRIREQLFSSLLRQDLGFF-QETKT-GELNSRLSSDTTLMSNWLPLNANVL 68
Query: 865 LQGISSVV--VGFLLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESAT 922
L+ + VV GF+L+IS +LTL++ + +P + + + Q+ + ++A+ A
Sbjct: 69 LRSLVKVVGLYGFMLSISP--RLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAG 126
Query: 923 AIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVAYKTRWRGLVYGLGVYIPFMAYC 982
+ EAV ++TV+S G E + ++++AL+ C + ++ +Y L + +
Sbjct: 127 QVVREAVGGLQTVRSFGAEEHEVCRYKEALEQ-CRQLYWRRDLERTLYLLVRRVLHLGVQ 185
Query: 983 SATVY-GAVLVAYGEMEYKLVL---LVNEAIMYGAYMLGQSLVYAPSLNTAKACGARILS 1038
+ G + GE+ +L + E++ G+Y+ +Y L+ A ++ S
Sbjct: 186 MLMLSCGLQQMQDGELTQGSLLSFMIYQESV--GSYVQTLVYIYGDMLSNVGAA-EKVFS 242
Query: 1039 IIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTIALV 1098
+ RQP + + + G +DV F YP RP + VLKG+ + G+ ALV
Sbjct: 243 YMDRQPNLPSPGTLAPT---TLQGIVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALV 299
Query: 1099 GSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLA 1158
G +G GKST+ L Q Y P G + LD + I S L Q+ V QEPVL S+
Sbjct: 300 GPNGSGKSTVAALLQNLYQPTGGQVLLDEKPI-SQYEHCYLHSQVVSVGQEPVLFSGSVR 358
Query: 1159 ENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAV-TEALEKAAK 1204
NIAYG + +++AAA+AA+ FI + + T+ EK ++
Sbjct: 359 NNIAYG--LQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQ 403
>AB208953-1|BAD92190.1| 704|Homo sapiens transporter 2, ATP-binding
cassette, sub-family B isoform 1 variant protein.
Length = 704
Score = 227 bits (554), Expect = 3e-58
Identities = 151/490 (30%), Positives = 246/490 (50%), Gaps = 17/490 (3%)
Query: 140 RIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLC 199
RIR S+LRQD+ ++ L S++S + + + V+ + V
Sbjct: 225 RIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYG 284
Query: 200 TAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREME-SYSLAGKQAEEILKSVRTI 258
+ +LTL MPF++ + N + + +RE++ + + AG+ E + ++T+
Sbjct: 285 FMLSISPRLTLLSLLHMPFTIAAE-KVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTV 343
Query: 259 VAFGGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVND 318
+FG E EV RY+ LE + +R L L VL + + S G + + +
Sbjct: 344 RSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDG 403
Query: 319 FDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKID 378
T +L + +Y Y+ Q++ + + +F ++R+P +
Sbjct: 404 ELTQGSLLSF---MIYQESVGSYV--QTLVYIYGDM---LSNVGAAEKVFSYMDRQPNLP 455
Query: 379 SLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTV 438
S L P + G + +DV F YP+RP+ VLKG + ++PGE ALVG +G GKSTV
Sbjct: 456 S--PGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV 513
Query: 439 LQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEAT 498
LLQ LY P G V +L S + VGQEPVLF G++ +NIA G
Sbjct: 514 AALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE 573
Query: 499 REEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 558
+++ A+ A+A DFI + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDE
Sbjct: 574 DDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDE 633
Query: 559 ATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLM 618
ATSALD E+ +Q R RT + ++HRL + A +I+ + +G + + L
Sbjct: 634 ATSALDVQCEQALQDWNSRGD--RTVLVIAHRLQAVQRAHQILVLQEGKLQKLA---QLQ 688
Query: 619 KAKGFYHKLV 628
+ + Y +LV
Sbjct: 689 EGQDLYSRLV 698
Score = 158 bits (383), Expect = 1e-37
Identities = 139/486 (28%), Positives = 238/486 (48%), Gaps = 26/486 (5%)
Query: 727 WQLLKLNAPEWPLITVGSIAAFLQGACFPVFALLFGFSSGIFILDNRDDIIYLADLYSVL 786
W+LLKL+ P+ PL+ +AAF + L SG I D A ++
Sbjct: 140 WRLLKLSRPDLPLL----VAAFFFLVLAVLGETLIPHYSGRVIDILGGDFDPHAFASAIF 195
Query: 787 FVVIAAV-AGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICAR 845
F+ + + + +S + FT ++ R+R Q F+SLL+Q++GFF +ET T G + +R
Sbjct: 196 FMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFF-QETKT-GELNSR 253
Query: 846 LSGDTAEVQGATGLRIGLILQGISSVV--VGFLLAISYNWKLTLVATVFLPLMVGSIWLE 903
LS DT + L ++L+ + VV GF+L+IS +LTL++ + +P + + +
Sbjct: 254 LSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISP--RLTLLSLLHMPFTIAAEKVY 311
Query: 904 GIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVAYKT 963
Q+ + ++A+ A + EAV ++TV+S G E + ++++AL+ C + ++
Sbjct: 312 NTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQ-CRQLYWRR 370
Query: 964 RWRGLVYGLGVYIPFMAYCSATVY-GAVLVAYGEMEYKLVL---LVNEAIMYGAYMLGQS 1019
+Y L + + + G + GE+ +L + E++ G+Y+
Sbjct: 371 DLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESV--GSYVQTLV 428
Query: 1020 LVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQ 1079
+Y L+ A ++ S + RQP + + + G +DV F YP RP +
Sbjct: 429 YIYGDMLSNVGAA-EKVFSYMDRQPNLPSPGTLAPT---TLQGVVKFQDVSFAYPNRPDR 484
Query: 1080 RVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRL 1139
VLKG+ + G+ ALVG +G GKST+ L Q Y P G + LD + I S L
Sbjct: 485 PVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPI-SQYEHCYL 543
Query: 1140 RRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAV-TEA 1198
Q+ V QEPVL S+ NIAYG + +++AAA+AA+ FI + + T+
Sbjct: 544 HSQVVSVGQEPVLFSGSVRNNIAYG--LQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDV 601
Query: 1199 LEKAAK 1204
EK ++
Sbjct: 602 GEKGSQ 607
>Z22936-1|CAA80523.1| 686|Homo sapiens TAP2E protein.
Length = 686
Score = 226 bits (552), Expect = 4e-58
Identities = 147/468 (31%), Positives = 237/468 (50%), Gaps = 14/468 (2%)
Query: 140 RIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLC 199
RIR S+LRQD+ ++ L S++S + + + V+ + V
Sbjct: 224 RIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYG 283
Query: 200 TAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREME-SYSLAGKQAEEILKSVRTI 258
+ +LTL MPF++ + N + + +RE++ + + AG+ E + ++T+
Sbjct: 284 FMLSISPRLTLLSLLHMPFTIAAE-KVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTV 342
Query: 259 VAFGGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVND 318
+FG E EV RY+ LE + +R L L VL + + S G + + +
Sbjct: 343 RSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDG 402
Query: 319 FDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKID 378
T +L + +Y Y+ Q++ + + +F ++R+P +
Sbjct: 403 ELTQGSLLSF---MIYQESVGSYV--QTLVYIYGDM---LSNVGAAEKVFSYMDRQPNLP 454
Query: 379 SLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTV 438
S L P + G + +DV F YP+RP+ VLKG + ++PGE ALVG +G GKSTV
Sbjct: 455 S--PGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV 512
Query: 439 LQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEAT 498
LLQ LY P G V +L S + VGQEPVLF G++ +NI G
Sbjct: 513 AALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNITYGLQSCE 572
Query: 499 REEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 558
+++ A+ A+A DFI + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDE
Sbjct: 573 DDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDE 632
Query: 559 ATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQG 606
ATSALD E+ +Q R RT + ++HRL T+ A +I+ + +G
Sbjct: 633 ATSALDVQCEQALQDWNSRGD--RTVLVIAHRLQTVQRAHQILVLQEG 678
Score = 156 bits (379), Expect = 4e-37
Identities = 138/486 (28%), Positives = 237/486 (48%), Gaps = 26/486 (5%)
Query: 727 WQLLKLNAPEWPLITVGSIAAFLQGACFPVFALLFGFSSGIFILDNRDDIIYLADLYSVL 786
W+LLKL+ P+ PL+ +AAF + L SG I D A ++
Sbjct: 139 WRLLKLSRPDLPLL----VAAFFFLVLAVLGETLIPHYSGRVIDILGGDFDPHAFASAIF 194
Query: 787 FVVIAAV-AGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICAR 845
F+ + + + +S + FT ++ R+R Q F+SLL+Q++GFF +ET T G + +R
Sbjct: 195 FMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFF-QETKT-GELNSR 252
Query: 846 LSGDTAEVQGATGLRIGLILQGISSVV--VGFLLAISYNWKLTLVATVFLPLMVGSIWLE 903
LS DT + L ++L+ + VV GF+L+IS +LTL++ + +P + + +
Sbjct: 253 LSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISP--RLTLLSLLHMPFTIAAEKVY 310
Query: 904 GIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVAYKT 963
Q+ + ++A+ A + EAV ++TV+S G E + ++++AL+ C + ++
Sbjct: 311 NTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQ-CRQLYWRR 369
Query: 964 RWRGLVYGLGVYIPFMAYCSATVY-GAVLVAYGEMEYKLVL---LVNEAIMYGAYMLGQS 1019
+Y L + + + G + GE+ +L + E++ G+Y+
Sbjct: 370 DLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESV--GSYVQTLV 427
Query: 1020 LVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQ 1079
+Y L+ A ++ S + RQP + + + G +DV F YP RP +
Sbjct: 428 YIYGDMLSNVGAA-EKVFSYMDRQPNLPSPGTLAPT---TLQGVVKFQDVSFAYPNRPDR 483
Query: 1080 RVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRL 1139
VLKG+ + G+ ALVG +G GKST+ L Q Y P G + LD + I S L
Sbjct: 484 PVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPI-SQYEHCYL 542
Query: 1140 RRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAV-TEA 1198
Q+ V QEPVL S+ NI YG + +++AAA+AA+ FI + + T+
Sbjct: 543 HSQVVSVGQEPVLFSGSVRNNITYG--LQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDV 600
Query: 1199 LEKAAK 1204
EK ++
Sbjct: 601 GEKGSQ 606
>AB073779-1|BAB71769.1| 703|Homo sapiens ABC-transporter protein.
Length = 703
Score = 226 bits (552), Expect = 4e-58
Identities = 151/490 (30%), Positives = 246/490 (50%), Gaps = 17/490 (3%)
Query: 140 RIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLC 199
RIR S+LRQD+ ++ L S++S + + + V+ + V
Sbjct: 224 RIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYG 283
Query: 200 TAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREME-SYSLAGKQAEEILKSVRTI 258
+ +LTL MPF++ + N + + +RE++ + + AG+ E + ++T+
Sbjct: 284 FMLSISPRLTLLSLLHMPFTIAAE-KVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTV 342
Query: 259 VAFGGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVND 318
+FG E EV RY+ LE + +R L L VL + + S G + + +
Sbjct: 343 RSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDG 402
Query: 319 FDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKID 378
T +L + +Y Y+ Q++ + + +F ++R+P +
Sbjct: 403 ELTQGSLLSF---MIYQESVGSYV--QTLVYIYGDM---LSNVGAAEKVFSYMDRQPNLP 454
Query: 379 SLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTV 438
S L P + G + +DV F YP+RP+ VLKG + ++PGE ALVG +G GKSTV
Sbjct: 455 S--PGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV 512
Query: 439 LQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEAT 498
LLQ LY P G V +L S + VGQEPVLF G++ +NIA G
Sbjct: 513 AALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE 572
Query: 499 REEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 558
+++ A+ A+A DFI + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDE
Sbjct: 573 DDKVVAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDE 632
Query: 559 ATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLM 618
ATSALD E+ +Q R RT + ++HRL + A +I+ + +G + + L
Sbjct: 633 ATSALDVQCEQALQDWNSRGD--RTVLVIAHRLQAVQRAHQILVLQEGKLQKLA---QLQ 687
Query: 619 KAKGFYHKLV 628
+ + Y +LV
Sbjct: 688 EGQDLYSRLV 697
Score = 159 bits (386), Expect = 6e-38
Identities = 140/486 (28%), Positives = 238/486 (48%), Gaps = 26/486 (5%)
Query: 727 WQLLKLNAPEWPLITVGSIAAFLQGACFPVFALLFGFSSGIFILDNRDDIIYLADLYSVL 786
W+LLKL+ P+ PL+ +AAF + L SG I D A ++
Sbjct: 139 WRLLKLSRPDLPLL----VAAFFFLVLAVLGETLIPHYSGRVIDILGGDFDPHAFASAIF 194
Query: 787 FVVIAAV-AGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICAR 845
F+ + + + +S + FT ++ R+R Q F+SLL+Q++GFF +ET T G + +R
Sbjct: 195 FMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFF-QETKT-GELNSR 252
Query: 846 LSGDTAEVQGATGLRIGLILQGISSVV--VGFLLAISYNWKLTLVATVFLPLMVGSIWLE 903
LS DT + L ++L+ + VV GF+L+IS +LTL++ + +P + + +
Sbjct: 253 LSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISP--RLTLLSLLHMPFTIAAEKVY 310
Query: 904 GIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVAYKT 963
Q+ + ++A+ A + EAV ++TV+S G E + ++++AL+ C + ++
Sbjct: 311 NTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQ-CRQLYWRR 369
Query: 964 RWRGLVYGLGVYIPFMAYCSATVY-GAVLVAYGEMEYKLVL---LVNEAIMYGAYMLGQS 1019
+Y L + + + G + GE+ +L + E++ G+Y+
Sbjct: 370 DLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESV--GSYVQTLV 427
Query: 1020 LVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQ 1079
+Y L+ A ++ S + RQP + + + G +DV F YP RP +
Sbjct: 428 YIYGDMLSNVGAA-EKVFSYMDRQPNLPSPGTLAPT---TLQGVVKFQDVSFAYPNRPDR 483
Query: 1080 RVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRL 1139
VLKG+ + G+ ALVG +G GKST+ L Q Y P G + LD + I S L
Sbjct: 484 PVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPI-SQYEHCYL 542
Query: 1140 RRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAV-TEA 1198
Q+ V QEPVL S+ NIAYG + ++VAAA+AA+ FI + + T+
Sbjct: 543 HSQVVSVGQEPVLFSGSVRNNIAYG--LQSCEDDKVVAAAQAAHADDFIQEMEHGIYTDV 600
Query: 1199 LEKAAK 1204
EK ++
Sbjct: 601 GEKGSQ 606
>AF136750-1|AAD23601.1| 483|Homo sapiens TAP2 protein protein.
Length = 483
Score = 225 bits (549), Expect = 1e-57
Identities = 147/468 (31%), Positives = 237/468 (50%), Gaps = 14/468 (2%)
Query: 140 RIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLC 199
RIR S+LRQD+ ++ L S++S + + + V+ + V
Sbjct: 21 RIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYG 80
Query: 200 TAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREME-SYSLAGKQAEEILKSVRTI 258
+ +LTL MPF++ + N + + +RE++ + + AG+ E + ++T+
Sbjct: 81 FMLSISPRLTLLSLLHMPFTIAAE-KVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTV 139
Query: 259 VAFGGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVND 318
+FG E EV RY+ LE + +R L L VL + + S G + + +
Sbjct: 140 RSFGAEEHEVCRYKEALEQCRQLYWRRDLERTLYLLVRRVLHLGVQMLMLSCGLQQMQDG 199
Query: 319 FDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKID 378
T +L + +Y Y+ Q++ + + +F ++R+P +
Sbjct: 200 ELTQGSLLSF---MIYQESVGSYV--QTLVYIYGDM---LSNVGAAEKVFSYMDRQPNLP 251
Query: 379 SLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTV 438
S L P + G + +DV F YP+RP+ VLKG + ++PGE ALVG +G GKSTV
Sbjct: 252 S--PGTLAPTTLQGIVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV 309
Query: 439 LQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEAT 498
LLQ LY P G V +L S + VGQEPVLF G++ +NIA G
Sbjct: 310 AALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE 369
Query: 499 REEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 558
+++ A+ A+A DFI + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDE
Sbjct: 370 DDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDE 429
Query: 559 ATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQG 606
ATSALD E+ +Q R RT + ++HRL + A +I+ + +G
Sbjct: 430 ATSALDVQCEQALQDWNSRGD--RTVLVIAHRLQAVQRAHQILVLQEG 475
Score = 149 bits (360), Expect = 8e-35
Identities = 120/407 (29%), Positives = 205/407 (50%), Gaps = 21/407 (5%)
Query: 805 FTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLI 864
FT ++ R+R Q F+SLL+Q++GFF +ET T G + +RLS DT + L ++
Sbjct: 11 FTYTMSRINLRIREQLFSSLLRQDLGFF-QETKT-GELNSRLSSDTTLMSNWLPLNANVL 68
Query: 865 LQGISSVV--VGFLLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESAT 922
L+ + VV GF+L+IS +LTL++ + +P + + + Q+ + ++A+ A
Sbjct: 69 LRSLVKVVGLYGFMLSISP--RLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAG 126
Query: 923 AIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVAYKTRWRGLVYGLGVYIPFMAYC 982
+ EAV ++TV+S G E + ++++AL+ C + ++ +Y L + +
Sbjct: 127 QVVREAVGGLQTVRSFGAEEHEVCRYKEALEQ-CRQLYWRRDLERTLYLLVRRVLHLGVQ 185
Query: 983 SATVY-GAVLVAYGEMEYKLVL---LVNEAIMYGAYMLGQSLVYAPSLNTAKACGARILS 1038
+ G + GE+ +L + E++ G+Y+ +Y L+ A ++ S
Sbjct: 186 MLMLSCGLQQMQDGELTQGSLLSFMIYQESV--GSYVQTLVYIYGDMLSNVGAA-EKVFS 242
Query: 1039 IIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTIALV 1098
+ RQP + + + G +DV F YP RP + VLKG+ + G+ ALV
Sbjct: 243 YMDRQPNLPSPGTLAPT---TLQGIVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALV 299
Query: 1099 GSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLA 1158
G +G GKST+ L Q Y P G + LD + I S L Q+ V QEPVL S+
Sbjct: 300 GPNGSGKSTVAALLQNLYQPTGGQVLLDEKPI-SQYEHCYLHSQVVSVGQEPVLFSGSVR 358
Query: 1159 ENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAV-TEALEKAAK 1204
NIAYG + +++AAA+AA+ FI + + T+ EK ++
Sbjct: 359 NNIAYG--LQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQ 403
>BC000559-1|AAH00559.1| 842|Homo sapiens ATP-binding cassette,
sub-family B (MDR/TAP), member 6 protein.
Length = 842
Score = 224 bits (548), Expect = 1e-57
Identities = 147/410 (35%), Positives = 215/410 (52%), Gaps = 13/410 (3%)
Query: 216 MPFSVITSIALSNYQTKSSIREMESYSLAGK-QAEEILKSVRTIVAFGGENKEVERYRRL 274
M + +I ++ ++TK R M + A + +A + L + T+ + E+ EVERYR
Sbjct: 421 MSLYLTLTIVVTEWRTKFR-RAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREA 479
Query: 275 LEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVY 334
+ + K L N ++ +G G+ L F T+ L+
Sbjct: 480 IIKYQGLEWKSSASLVLLNQTQNLVI----GLGLLAGSLLCAY-FVTEQKLQVGDYVLFG 534
Query: 335 SILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPRRVVGDI 394
+ + +YM + + + ++F L++ E ++ L G R G I
Sbjct: 535 TYIIQLYMP---LNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPL-RFQKGRI 590
Query: 395 LLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVX 454
E+V F Y E L+ S V PG+ +ALVG SG GKST+L+LL R YD +G +
Sbjct: 591 EFENVHFSYADGRET--LQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIR 648
Query: 455 XXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDF 514
+ LRS +GVV Q+ VLF TI DNI G A +E++ A+ A HD
Sbjct: 649 IDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHDA 708
Query: 515 ISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAA 574
I P GY T +GERG LSGG+KQR+AIAR++L+ P ++LLDEATSALD +ER +QA+
Sbjct: 709 IMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQAS 768
Query: 575 LDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFY 624
L + RTTI V+HRLST+VNAD+I+ + G IVE+G HE L+ G Y
Sbjct: 769 LAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVY 818
Score = 105 bits (251), Expect = 1e-21
Identities = 99/375 (26%), Positives = 187/375 (49%), Gaps = 45/375 (12%)
Query: 850 TAEVQGATGLRIGLILQGISSVVVGFL-LAISYNWKLTLVATVFLPLMVGSIWLEGIISQ 908
T+ V G + ++ ++ +++G + ++ +N L+ VFL + + + L ++++
Sbjct: 377 TSSVTGLLSYLVFNVIPTLADIIIGIIYFSMFFNAWFGLI--VFLCMSL-YLTLTIVVTE 433
Query: 909 KAQIDER--NAMESAT-AIATEAVVSIKTVQSLGVETVFLQKFQDALKT-------ACVA 958
R N E+AT A A +++++ +TV+ E+ ++++++A+ + +
Sbjct: 434 WRTKFRRAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREAIIKYQGLEWKSSAS 493
Query: 959 VAYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQ 1018
+ + + LV GLG+ + G++L AY E KL V + +++G Y++
Sbjct: 494 LVLLNQTQNLVIGLGL-----------LAGSLLCAYFVTEQKLQ--VGDYVLFGTYIIQL 540
Query: 1019 SL------VYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFC 1072
+ Y + T + +++ + ++ + G + G +V F
Sbjct: 541 YMPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPLR--FQKGRIEFENVHFS 598
Query: 1073 YPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRS 1132
Y + L+ + + G+T+ALVG SG GKSTIL+L RFYD SG I +D +DI S
Sbjct: 599 YAD--GRETLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDI-S 655
Query: 1133 ALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTM--HEIVAAAKAANIHSFIVS 1190
+T LR +GVV Q+ VL + ++A+NI YG +VT E+ AAA+AA IH I++
Sbjct: 656 QVTQASLRSHIGVVPQDTVLFNDTIADNIRYG----RVTAGNDEVEAAAQAAGIHDAIMA 711
Query: 1191 LPKAV-TEALEKAAK 1204
P+ T+ E+ K
Sbjct: 712 FPEGYRTQVGERGLK 726
Score = 59.3 bits (137), Expect = 9e-08
Identities = 32/66 (48%), Positives = 41/66 (62%), Gaps = 3/66 (4%)
Query: 1193 KAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHY---W 1249
+A+ +L K RT I +AHRLSTV +AD I VI G IVERG H L+S G Y W
Sbjct: 763 RAIQASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMW 822
Query: 1250 RMCRGQ 1255
++ +GQ
Sbjct: 823 QLQQGQ 828
>AK057026-1|BAB71347.1| 766|Homo sapiens protein ( Homo sapiens
cDNA FLJ32464 fis, clone SKNMC1000251, highly similar to
Homo sapiens MT-ABC transporter (MTABC) mRNA. ).
Length = 766
Score = 224 bits (548), Expect = 1e-57
Identities = 147/410 (35%), Positives = 215/410 (52%), Gaps = 13/410 (3%)
Query: 216 MPFSVITSIALSNYQTKSSIREMESYSLAGK-QAEEILKSVRTIVAFGGENKEVERYRRL 274
M + +I ++ ++TK R M + A + +A + L + T+ + E+ EVERYR
Sbjct: 345 MSLYLTLTIVVTEWRTKFR-RAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREA 403
Query: 275 LEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVY 334
+ + K L N ++ +G G+ L F T+ L+
Sbjct: 404 IIKYQGLEWKSSASLVLLNQTQNLVI----GLGLLAGSLLCAY-FVTEQKLQVGDYVLFG 458
Query: 335 SILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPRRVVGDI 394
+ + +YM + + + ++F L++ E ++ L G R G I
Sbjct: 459 TYIIQLYMP---LNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPL-RFQKGRI 514
Query: 395 LLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVX 454
E+V F Y E L+ S V PG+ +ALVG SG GKST+L+LL R YD +G +
Sbjct: 515 EFENVHFSYADGRET--LQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIR 572
Query: 455 XXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDF 514
+ LRS +GVV Q+ VLF TI DNI G A +E++ A+ A HD
Sbjct: 573 IDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHDA 632
Query: 515 ISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAA 574
I P GY T +GERG LSGG+KQR+AIAR++L+ P ++LLDEATSALD +ER +QA+
Sbjct: 633 IMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQAS 692
Query: 575 LDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFY 624
L + RTTI V+HRLST+VNAD+I+ + G IVE+G HE L+ G Y
Sbjct: 693 LAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVY 742
Score = 105 bits (251), Expect = 1e-21
Identities = 99/375 (26%), Positives = 187/375 (49%), Gaps = 45/375 (12%)
Query: 850 TAEVQGATGLRIGLILQGISSVVVGFL-LAISYNWKLTLVATVFLPLMVGSIWLEGIISQ 908
T+ V G + ++ ++ +++G + ++ +N L+ VFL + + + L ++++
Sbjct: 301 TSSVTGLLSYLVFNVIPTLADIIIGIIYFSMFFNAWFGLI--VFLCMSL-YLTLTIVVTE 357
Query: 909 KAQIDER--NAMESAT-AIATEAVVSIKTVQSLGVETVFLQKFQDALKT-------ACVA 958
R N E+AT A A +++++ +TV+ E+ ++++++A+ + +
Sbjct: 358 WRTKFRRAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREAIIKYQGLEWKSSAS 417
Query: 959 VAYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQ 1018
+ + + LV GLG+ + G++L AY E KL V + +++G Y++
Sbjct: 418 LVLLNQTQNLVIGLGL-----------LAGSLLCAYFVTEQKLQ--VGDYVLFGTYIIQL 464
Query: 1019 SL------VYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFC 1072
+ Y + T + +++ + ++ + G + G +V F
Sbjct: 465 YMPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPLR--FQKGRIEFENVHFS 522
Query: 1073 YPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRS 1132
Y + L+ + + G+T+ALVG SG GKSTIL+L RFYD SG I +D +DI S
Sbjct: 523 YAD--GRETLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDI-S 579
Query: 1133 ALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTM--HEIVAAAKAANIHSFIVS 1190
+T LR +GVV Q+ VL + ++A+NI YG +VT E+ AAA+AA IH I++
Sbjct: 580 QVTQASLRSHIGVVPQDTVLFNDTIADNIRYG----RVTAGNDEVEAAAQAAGIHDAIMA 635
Query: 1191 LPKAV-TEALEKAAK 1204
P+ T+ E+ K
Sbjct: 636 FPEGYRTQVGERGLK 650
Score = 59.3 bits (137), Expect = 9e-08
Identities = 32/66 (48%), Positives = 41/66 (62%), Gaps = 3/66 (4%)
Query: 1193 KAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHY---W 1249
+A+ +L K RT I +AHRLSTV +AD I VI G IVERG H L+S G Y W
Sbjct: 687 RAIQASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMW 746
Query: 1250 RMCRGQ 1255
++ +GQ
Sbjct: 747 QLQQGQ 752
>AJ289233-1|CAB95766.2| 842|Homo sapiens ABC transporter umat
protein.
Length = 842
Score = 224 bits (548), Expect = 1e-57
Identities = 147/410 (35%), Positives = 215/410 (52%), Gaps = 13/410 (3%)
Query: 216 MPFSVITSIALSNYQTKSSIREMESYSLAGK-QAEEILKSVRTIVAFGGENKEVERYRRL 274
M + +I ++ ++TK R M + A + +A + L + T+ + E+ EVERYR
Sbjct: 421 MSLYLTLTIVVTEWRTKFR-RAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREA 479
Query: 275 LEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVY 334
+ + K L N ++ +G G+ L F T+ L+
Sbjct: 480 IIKYQGLEWKSSASLVLLNQTQNLVI----GLGLLAGSLLCAY-FVTEQKLQVGDYVLFG 534
Query: 335 SILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPRRVVGDI 394
+ + +YM + + + ++F L++ E ++ L G R G I
Sbjct: 535 TYIIQLYMP---LNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPL-RFQKGRI 590
Query: 395 LLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVX 454
E+V F Y E L+ S V PG+ +ALVG SG GKST+L+LL R YD +G +
Sbjct: 591 EFENVHFSYADGRET--LQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIR 648
Query: 455 XXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDF 514
+ LRS +GVV Q+ VLF TI DNI G A +E++ A+ A HD
Sbjct: 649 IDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHDA 708
Query: 515 ISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAA 574
I P GY T +GERG LSGG+KQR+AIAR++L+ P ++LLDEATSALD +ER +QA+
Sbjct: 709 IMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQAS 768
Query: 575 LDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFY 624
L + RTTI V+HRLST+VNAD+I+ + G IVE+G HE L+ G Y
Sbjct: 769 LAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVY 818
Score = 105 bits (251), Expect = 1e-21
Identities = 99/375 (26%), Positives = 187/375 (49%), Gaps = 45/375 (12%)
Query: 850 TAEVQGATGLRIGLILQGISSVVVGFL-LAISYNWKLTLVATVFLPLMVGSIWLEGIISQ 908
T+ V G + ++ ++ +++G + ++ +N L+ VFL + + + L ++++
Sbjct: 377 TSSVTGLLSYLVFNVIPTLADIIIGIIYFSMFFNAWFGLI--VFLCMSL-YLTLTIVVTE 433
Query: 909 KAQIDER--NAMESAT-AIATEAVVSIKTVQSLGVETVFLQKFQDALKT-------ACVA 958
R N E+AT A A +++++ +TV+ E+ ++++++A+ + +
Sbjct: 434 WRTKFRRAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREAIIKYQGLEWKSSAS 493
Query: 959 VAYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQ 1018
+ + + LV GLG+ + G++L AY E KL V + +++G Y++
Sbjct: 494 LVLLNQTQNLVIGLGL-----------LAGSLLCAYFVTEQKLQ--VGDYVLFGTYIIQL 540
Query: 1019 SL------VYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFC 1072
+ Y + T + +++ + ++ + G + G +V F
Sbjct: 541 YMPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPLR--FQKGRIEFENVHFS 598
Query: 1073 YPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRS 1132
Y + L+ + + G+T+ALVG SG GKSTIL+L RFYD SG I +D +DI S
Sbjct: 599 YAD--GRETLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDI-S 655
Query: 1133 ALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTM--HEIVAAAKAANIHSFIVS 1190
+T LR +GVV Q+ VL + ++A+NI YG +VT E+ AAA+AA IH I++
Sbjct: 656 QVTQASLRSHIGVVPQDTVLFNDTIADNIRYG----RVTAGNDEVEAAAQAAGIHDAIMA 711
Query: 1191 LPKAV-TEALEKAAK 1204
P+ T+ E+ K
Sbjct: 712 FPEGYRTQVGERGLK 726
Score = 59.3 bits (137), Expect = 9e-08
Identities = 32/66 (48%), Positives = 41/66 (62%), Gaps = 3/66 (4%)
Query: 1193 KAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHY---W 1249
+A+ +L K RT I +AHRLSTV +AD I VI G IVERG H L+S G Y W
Sbjct: 763 RAIQASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMW 822
Query: 1250 RMCRGQ 1255
++ +GQ
Sbjct: 823 QLQQGQ 828
>AF308472-1|AAG33617.1| 896|Homo sapiens ATP-binding cassette
half-transporter protein.
Length = 896
Score = 224 bits (548), Expect = 1e-57
Identities = 147/410 (35%), Positives = 215/410 (52%), Gaps = 13/410 (3%)
Query: 216 MPFSVITSIALSNYQTKSSIREMESYSLAGK-QAEEILKSVRTIVAFGGENKEVERYRRL 274
M + +I ++ ++TK R M + A + +A + L + T+ + E+ EVERYR
Sbjct: 475 MSLYLTLTIVVTEWRTKFR-RAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREA 533
Query: 275 LEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVY 334
+ + K L N ++ +G G+ L F T+ L+
Sbjct: 534 IIKYQGLEWKSSASLVLLNQTQNLVI----GLGLLAGSLLCAY-FVTEQKLQVGDYVLFG 588
Query: 335 SILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPRRVVGDI 394
+ + +YM + + + ++F L++ E ++ L G R G I
Sbjct: 589 TYIIQLYMP---LNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPL-RFQKGRI 644
Query: 395 LLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVX 454
E+V F Y E L+ S V PG+ +ALVG SG GKST+L+LL R YD +G +
Sbjct: 645 EFENVHFSYADGRET--LQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIR 702
Query: 455 XXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDF 514
+ LRS +GVV Q+ VLF TI DNI G A +E++ A+ A HD
Sbjct: 703 IDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHDA 762
Query: 515 ISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAA 574
I P GY T +GERG LSGG+KQR+AIAR++L+ P ++LLDEATSALD +ER +QA+
Sbjct: 763 IMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQAS 822
Query: 575 LDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFY 624
L + RTTI V+HRLST+VNAD+I+ + G IVE+G HE L+ G Y
Sbjct: 823 LAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVY 872
Score = 105 bits (251), Expect = 1e-21
Identities = 99/375 (26%), Positives = 187/375 (49%), Gaps = 45/375 (12%)
Query: 850 TAEVQGATGLRIGLILQGISSVVVGFL-LAISYNWKLTLVATVFLPLMVGSIWLEGIISQ 908
T+ V G + ++ ++ +++G + ++ +N L+ VFL + + + L ++++
Sbjct: 431 TSSVTGLLSYLVFNVIPTLADIIIGIIYFSMFFNAWFGLI--VFLCMSL-YLTLTIVVTE 487
Query: 909 KAQIDER--NAMESAT-AIATEAVVSIKTVQSLGVETVFLQKFQDALKT-------ACVA 958
R N E+AT A A +++++ +TV+ E+ ++++++A+ + +
Sbjct: 488 WRTKFRRAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREAIIKYQGLEWKSSAS 547
Query: 959 VAYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQ 1018
+ + + LV GLG+ + G++L AY E KL V + +++G Y++
Sbjct: 548 LVLLNQTQNLVIGLGL-----------LAGSLLCAYFVTEQKLQ--VGDYVLFGTYIIQL 594
Query: 1019 SL------VYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFC 1072
+ Y + T + +++ + ++ + G + G +V F
Sbjct: 595 YMPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPLR--FQKGRIEFENVHFS 652
Query: 1073 YPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRS 1132
Y + L+ + + G+T+ALVG SG GKSTIL+L RFYD SG I +D +DI S
Sbjct: 653 YAD--GRETLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDI-S 709
Query: 1133 ALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTM--HEIVAAAKAANIHSFIVS 1190
+T LR +GVV Q+ VL + ++A+NI YG +VT E+ AAA+AA IH I++
Sbjct: 710 QVTQASLRSHIGVVPQDTVLFNDTIADNIRYG----RVTAGNDEVEAAAQAAGIHDAIMA 765
Query: 1191 LPKAV-TEALEKAAK 1204
P+ T+ E+ K
Sbjct: 766 FPEGYRTQVGERGLK 780
Score = 59.3 bits (137), Expect = 9e-08
Identities = 32/66 (48%), Positives = 41/66 (62%), Gaps = 3/66 (4%)
Query: 1193 KAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHY---W 1249
+A+ +L K RT I +AHRLSTV +AD I VI G IVERG H L+S G Y W
Sbjct: 817 RAIQASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMW 876
Query: 1250 RMCRGQ 1255
++ +GQ
Sbjct: 877 QLQQGQ 882
>AF076775-1|AAF75107.1| 842|Homo sapiens MT-ABC transporter
protein.
Length = 842
Score = 224 bits (548), Expect = 1e-57
Identities = 147/410 (35%), Positives = 215/410 (52%), Gaps = 13/410 (3%)
Query: 216 MPFSVITSIALSNYQTKSSIREMESYSLAGK-QAEEILKSVRTIVAFGGENKEVERYRRL 274
M + +I ++ ++TK R M + A + +A + L + T+ + E+ EVERYR
Sbjct: 421 MSLYLTLTIVVTEWRTKFR-RAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREA 479
Query: 275 LEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVY 334
+ + K L N ++ +G G+ L F T+ L+
Sbjct: 480 IIKYQGLEWKSSASLVLLNQTQNLVI----GLGLLAGSLLCAY-FVTEQKLQVGDYVLFG 534
Query: 335 SILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPRRVVGDI 394
+ + +YM + + + ++F L++ E ++ L G R G I
Sbjct: 535 TYIIQLYMP---LNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPL-RFQKGRI 590
Query: 395 LLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVX 454
E+V F Y E L+ S V PG+ +ALVG SG GKST+L+LL R YD +G +
Sbjct: 591 EFENVHFSYADGRET--LQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIR 648
Query: 455 XXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDF 514
+ LRS +GVV Q+ VLF TI DNI G A +E++ A+ A HD
Sbjct: 649 IDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHDA 708
Query: 515 ISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAA 574
I P GY T +GERG LSGG+KQR+AIAR++L+ P ++LLDEATSALD +ER +QA+
Sbjct: 709 IMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQAS 768
Query: 575 LDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFY 624
L + RTTI V+HRLST+VNAD+I+ + G IVE+G HE L+ G Y
Sbjct: 769 LAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVY 818
Score = 105 bits (251), Expect = 1e-21
Identities = 99/375 (26%), Positives = 187/375 (49%), Gaps = 45/375 (12%)
Query: 850 TAEVQGATGLRIGLILQGISSVVVGFL-LAISYNWKLTLVATVFLPLMVGSIWLEGIISQ 908
T+ V G + ++ ++ +++G + ++ +N L+ VFL + + + L ++++
Sbjct: 377 TSSVTGLLSYLVFNVIPTLADIIIGIIYFSMFFNAWFGLI--VFLCMSL-YLTLTIVVTE 433
Query: 909 KAQIDER--NAMESAT-AIATEAVVSIKTVQSLGVETVFLQKFQDALKT-------ACVA 958
R N E+AT A A +++++ +TV+ E+ ++++++A+ + +
Sbjct: 434 WRTKFRRAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREAIIKYQGLEWKSSAS 493
Query: 959 VAYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQ 1018
+ + + LV GLG+ + G++L AY E KL V + +++G Y++
Sbjct: 494 LVLLNQTQNLVIGLGL-----------LAGSLLCAYFVTEQKLQ--VGDYVLFGTYIIQL 540
Query: 1019 SL------VYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFC 1072
+ Y + T + +++ + ++ + G + G +V F
Sbjct: 541 YMPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPLR--FQKGRIEFENVHFS 598
Query: 1073 YPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRS 1132
Y + L+ + + G+T+ALVG SG GKSTIL+L RFYD SG I +D +DI S
Sbjct: 599 YAD--GRETLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDI-S 655
Query: 1133 ALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTM--HEIVAAAKAANIHSFIVS 1190
+T LR +GVV Q+ VL + ++A+NI YG +VT E+ AAA+AA IH I++
Sbjct: 656 QVTQASLRSHIGVVPQDTVLFNDTIADNIRYG----RVTAGNDEVEAAAQAAGIHDAIMA 711
Query: 1191 LPKAV-TEALEKAAK 1204
P+ T+ E+ K
Sbjct: 712 FPEGYRTQVGERGLK 726
Score = 59.3 bits (137), Expect = 9e-08
Identities = 32/66 (48%), Positives = 41/66 (62%), Gaps = 3/66 (4%)
Query: 1193 KAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHY---W 1249
+A+ +L K RT I +AHRLSTV +AD I VI G IVERG H L+S G Y W
Sbjct: 763 RAIQASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMW 822
Query: 1250 RMCRGQ 1255
++ +GQ
Sbjct: 823 QLQQGQ 828
>AF070598-1|AAC28653.1| 511|Homo sapiens ABC transporter protein.
Length = 511
Score = 224 bits (548), Expect = 1e-57
Identities = 147/410 (35%), Positives = 215/410 (52%), Gaps = 13/410 (3%)
Query: 216 MPFSVITSIALSNYQTKSSIREMESYSLAGK-QAEEILKSVRTIVAFGGENKEVERYRRL 274
M + +I ++ ++TK R M + A + +A + L + T+ + E+ EVERYR
Sbjct: 90 MSLYLTLTIVVTEWRTKFR-RAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREA 148
Query: 275 LEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVY 334
+ + K L N ++ +G G+ L F T+ L+
Sbjct: 149 IIKYQGLEWKSSASLVLLNQTQNLVI----GLGLLAGSLLCAY-FVTEQKLQVGDYVLFG 203
Query: 335 SILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPRRVVGDI 394
+ + +YM + + + ++F L++ E ++ L G R G I
Sbjct: 204 TYIIQLYMP---LNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPL-RFQKGRI 259
Query: 395 LLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVX 454
E+V F Y E L+ S V PG+ +ALVG SG GKST+L+LL R YD +G +
Sbjct: 260 EFENVHFSYADGRET--LQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIR 317
Query: 455 XXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDF 514
+ LRS +GVV Q+ VLF TI DNI G A +E++ A+ A HD
Sbjct: 318 IDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHDA 377
Query: 515 ISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAA 574
I P GY T +GERG LSGG+KQR+AIAR++L+ P ++LLDEATSALD +ER +QA+
Sbjct: 378 IMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQAS 437
Query: 575 LDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFY 624
L + RTTI V+HRLST+VNAD+I+ + G IVE+G HE L+ G Y
Sbjct: 438 LAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVY 487
Score = 105 bits (251), Expect = 1e-21
Identities = 99/375 (26%), Positives = 187/375 (49%), Gaps = 45/375 (12%)
Query: 850 TAEVQGATGLRIGLILQGISSVVVGFL-LAISYNWKLTLVATVFLPLMVGSIWLEGIISQ 908
T+ V G + ++ ++ +++G + ++ +N L+ VFL + + + L ++++
Sbjct: 46 TSSVTGLLSYLVFNVIPTLADIIIGIIYFSMFFNAWFGLI--VFLCMSL-YLTLTIVVTE 102
Query: 909 KAQIDER--NAMESAT-AIATEAVVSIKTVQSLGVETVFLQKFQDALKT-------ACVA 958
R N E+AT A A +++++ +TV+ E+ ++++++A+ + +
Sbjct: 103 WRTKFRRAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREAIIKYQGLEWKSSAS 162
Query: 959 VAYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQ 1018
+ + + LV GLG+ + G++L AY E KL V + +++G Y++
Sbjct: 163 LVLLNQTQNLVIGLGL-----------LAGSLLCAYFVTEQKLQ--VGDYVLFGTYIIQL 209
Query: 1019 SL------VYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFC 1072
+ Y + T + +++ + ++ + G + G +V F
Sbjct: 210 YMPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPLR--FQKGRIEFENVHFS 267
Query: 1073 YPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRS 1132
Y + L+ + + G+T+ALVG SG GKSTIL+L RFYD SG I +D +DI S
Sbjct: 268 YAD--GRETLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDI-S 324
Query: 1133 ALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTM--HEIVAAAKAANIHSFIVS 1190
+T LR +GVV Q+ VL + ++A+NI YG +VT E+ AAA+AA IH I++
Sbjct: 325 QVTQASLRSHIGVVPQDTVLFNDTIADNIRYG----RVTAGNDEVEAAAQAAGIHDAIMA 380
Query: 1191 LPKAV-TEALEKAAK 1204
P+ T+ E+ K
Sbjct: 381 FPEGYRTQVGERGLK 395
Score = 59.3 bits (137), Expect = 9e-08
Identities = 32/66 (48%), Positives = 41/66 (62%), Gaps = 3/66 (4%)
Query: 1193 KAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHY---W 1249
+A+ +L K RT I +AHRLSTV +AD I VI G IVERG H L+S G Y W
Sbjct: 432 RAIQASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMW 491
Query: 1250 RMCRGQ 1255
++ +GQ
Sbjct: 492 QLQQGQ 497
>AB039371-1|BAA96733.1| 842|Homo sapiens mitochondrial ABC
transporter 3 protein.
Length = 842
Score = 224 bits (548), Expect = 1e-57
Identities = 147/410 (35%), Positives = 215/410 (52%), Gaps = 13/410 (3%)
Query: 216 MPFSVITSIALSNYQTKSSIREMESYSLAGK-QAEEILKSVRTIVAFGGENKEVERYRRL 274
M + +I ++ ++TK R M + A + +A + L + T+ + E+ EVERYR
Sbjct: 421 MSLYLTLTIVVTEWRTKFR-RAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREA 479
Query: 275 LEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVY 334
+ + K L N ++ +G G+ L F T+ L+
Sbjct: 480 IIKYQGLEWKSSASLVLLNQTQNLVI----GLGLLAGSLLCAY-FVTEQKLQVGDYVLFG 534
Query: 335 SILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPRRVVGDI 394
+ + +YM + + + ++F L++ E ++ L G R G I
Sbjct: 535 TYIIQLYMP---LNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPL-RFQKGRI 590
Query: 395 LLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVX 454
E+V F Y E L+ S V PG+ +ALVG SG GKST+L+LL R YD +G +
Sbjct: 591 EFENVHFSYADGRET--LQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIR 648
Query: 455 XXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDF 514
+ LRS +GVV Q+ VLF TI DNI G A +E++ A+ A HD
Sbjct: 649 IDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHDA 708
Query: 515 ISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAA 574
I P GY T +GERG LSGG+KQR+AIAR++L+ P ++LLDEATSALD +ER +QA+
Sbjct: 709 IMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQAS 768
Query: 575 LDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFY 624
L + RTTI V+HRLST+VNAD+I+ + G IVE+G HE L+ G Y
Sbjct: 769 LAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVY 818
Score = 105 bits (251), Expect = 1e-21
Identities = 99/375 (26%), Positives = 187/375 (49%), Gaps = 45/375 (12%)
Query: 850 TAEVQGATGLRIGLILQGISSVVVGFL-LAISYNWKLTLVATVFLPLMVGSIWLEGIISQ 908
T+ V G + ++ ++ +++G + ++ +N L+ VFL + + + L ++++
Sbjct: 377 TSSVTGLLSYLVFNVIPTLADIIIGIIYFSMFFNAWFGLI--VFLCMSL-YLTLTIVVTE 433
Query: 909 KAQIDER--NAMESAT-AIATEAVVSIKTVQSLGVETVFLQKFQDALKT-------ACVA 958
R N E+AT A A +++++ +TV+ E+ ++++++A+ + +
Sbjct: 434 WRTKFRRAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREAIIKYQGLEWKSSAS 493
Query: 959 VAYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQ 1018
+ + + LV GLG+ + G++L AY E KL V + +++G Y++
Sbjct: 494 LVLLNQTQNLVIGLGL-----------LAGSLLCAYFVTEQKLQ--VGDYVLFGTYIIQL 540
Query: 1019 SL------VYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFC 1072
+ Y + T + +++ + ++ + G + G +V F
Sbjct: 541 YMPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPLR--FQKGRIEFENVHFS 598
Query: 1073 YPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRS 1132
Y + L+ + + G+T+ALVG SG GKSTIL+L RFYD SG I +D +DI S
Sbjct: 599 YAD--GRETLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDI-S 655
Query: 1133 ALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTM--HEIVAAAKAANIHSFIVS 1190
+T LR +GVV Q+ VL + ++A+NI YG +VT E+ AAA+AA IH I++
Sbjct: 656 QVTQASLRSHIGVVPQDTVLFNDTIADNIRYG----RVTAGNDEVEAAAQAAGIHDAIMA 711
Query: 1191 LPKAV-TEALEKAAK 1204
P+ T+ E+ K
Sbjct: 712 FPEGYRTQVGERGLK 726
Score = 59.3 bits (137), Expect = 9e-08
Identities = 32/66 (48%), Positives = 41/66 (62%), Gaps = 3/66 (4%)
Query: 1193 KAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHY---W 1249
+A+ +L K RT I +AHRLSTV +AD I VI G IVERG H L+S G Y W
Sbjct: 763 RAIQASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMW 822
Query: 1250 RMCRGQ 1255
++ +GQ
Sbjct: 823 QLQQGQ 828
>BC043423-1|AAH43423.1| 301|Homo sapiens ABCB6 protein protein.
Length = 301
Score = 221 bits (540), Expect = 1e-56
Identities = 119/259 (45%), Positives = 159/259 (61%), Gaps = 3/259 (1%)
Query: 366 SIFHLIEREPKIDSLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECV 425
++F L++ E ++ L G R G I E+V F Y E L+ S V PG+ +
Sbjct: 22 NMFDLLKEETEVKDLPGAGPL-RFQKGRIEFENVHFSYADGRET--LQDVSFTVMPGQTL 78
Query: 426 ALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGT 485
ALVG SG GKST+L+LL R YD +G + + LRS +GVV Q+ VLF T
Sbjct: 79 ALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQASLRSHIGVVPQDTVLFNDT 138
Query: 486 IYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIAR 545
I DNI G A +E++ A+ A HD I P GY T +GERG LSGG+KQR+AIAR
Sbjct: 139 IADNIRYGRVTAGNDEVEAAAQAAGIHDAIMAFPEGYRTQVGERGLKLSGGEKQRVAIAR 198
Query: 546 SLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQ 605
++L+ P ++LLDEATSALD +ER +QA+L + RTTI V+HRLST+VNAD+I+ +
Sbjct: 199 TILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTTIVVAHRLSTVVNADQILVIKD 258
Query: 606 GVIVEQGTHEDLMKAKGFY 624
G IVE+G HE L+ G Y
Sbjct: 259 GCIVERGRHEALLSRGGVY 277
Score = 95.9 bits (228), Expect = 8e-19
Identities = 60/146 (41%), Positives = 85/146 (58%), Gaps = 10/146 (6%)
Query: 1062 GNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSG 1121
G +V F Y + L+ + + G+T+ALVG SG GKSTIL+L RFYD SG
Sbjct: 47 GRIEFENVHFSYAD--GRETLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSG 104
Query: 1122 FIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTM--HEIVAAA 1179
I +D +DI S +T LR +GVV Q+ VL + ++A+NI YG +VT E+ AAA
Sbjct: 105 CIRIDGQDI-SQVTQASLRSHIGVVPQDTVLFNDTIADNIRYG----RVTAGNDEVEAAA 159
Query: 1180 KAANIHSFIVSLPKAV-TEALEKAAK 1204
+AA IH I++ P+ T+ E+ K
Sbjct: 160 QAAGIHDAIMAFPEGYRTQVGERGLK 185
Score = 59.3 bits (137), Expect = 9e-08
Identities = 32/66 (48%), Positives = 41/66 (62%), Gaps = 3/66 (4%)
Query: 1193 KAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHY---W 1249
+A+ +L K RT I +AHRLSTV +AD I VI G IVERG H L+S G Y W
Sbjct: 222 RAIQASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMW 281
Query: 1250 RMCRGQ 1255
++ +GQ
Sbjct: 282 QLQQGQ 287
>AK223300-1|BAD97020.1| 703|Homo sapiens transporter 2, ATP-binding
cassette, sub-family B isoform 1 variant protein.
Length = 703
Score = 219 bits (534), Expect = 7e-56
Identities = 148/490 (30%), Positives = 243/490 (49%), Gaps = 17/490 (3%)
Query: 140 RIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLC 199
RIR S+LRQD+ ++ L S++S + + + V+ + V
Sbjct: 224 RIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYG 283
Query: 200 TAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREME-SYSLAGKQAEEILKSVRTI 258
+ +LTL MPF++ + N + + +RE++ + + AG+ E + ++T+
Sbjct: 284 FMLSISPRLTLLSLLHMPFTIAAE-KVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTV 342
Query: 259 VAFGGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVND 318
+ G E EV RY+ LE + +R L L VL + + S G + + +
Sbjct: 343 RSIGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDG 402
Query: 319 FDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKID 378
T +L + +Y Y+ Q++ + + +F ++R+P +
Sbjct: 403 ELTQGSLLSF---MIYQESVGSYV--QTLVYIYGDM---LSNVGAAEKVFSYMDRQPNLP 454
Query: 379 SLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTV 438
S L P + G + +DV F YP+RP+ VLKG + ++PGE ALVG +G GKSTV
Sbjct: 455 S--PGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV 512
Query: 439 LQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEAT 498
LLQ L P G V +L S + VGQEPVLF G++ +NIA G
Sbjct: 513 AALLQNLNQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE 572
Query: 499 REEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 558
+++ A+ A+A DFI + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDE
Sbjct: 573 DDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDE 632
Query: 559 ATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLM 618
ATSALD E+ +Q R R + ++HRL + A +I+ + +G + + L
Sbjct: 633 ATSALDVQCEQALQDWNSRGD--RAVLVIAHRLQAVQRAHQILVLQEGKLQKLA---QLQ 687
Query: 619 KAKGFYHKLV 628
+ + Y +LV
Sbjct: 688 EGQDLYSRLV 697
Score = 155 bits (376), Expect = 9e-37
Identities = 138/486 (28%), Positives = 238/486 (48%), Gaps = 26/486 (5%)
Query: 727 WQLLKLNAPEWPLITVGSIAAFLQGACFPVFALLFGFSSGIFILDNRDDIIYLADLYSVL 786
W+LLKL+ P+ PL+ +AAF + L SG I D A ++
Sbjct: 139 WRLLKLSRPDLPLL----VAAFFFLVLAVLGETLIPHYSGRVIDILGGDFDPHAFASAIF 194
Query: 787 FVVIAAV-AGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICAR 845
F+ + + + +S + FT ++ R+R Q F+SLL+Q++GFF +ET T G + +R
Sbjct: 195 FMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFF-QETKT-GELNSR 252
Query: 846 LSGDTAEVQGATGLRIGLILQGISSVV--VGFLLAISYNWKLTLVATVFLPLMVGSIWLE 903
LS DT + L ++L+ + VV GF+L+IS +LTL++ + +P + + +
Sbjct: 253 LSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISP--RLTLLSLLHMPFTIAAEKVY 310
Query: 904 GIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVAYKT 963
Q+ + ++A+ A + EAV ++TV+S+G E + ++++AL+ C + ++
Sbjct: 311 NTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSIGAEEHEVCRYKEALEQ-CRQLYWRR 369
Query: 964 RWRGLVYGLGVYIPFMAYCSATVY-GAVLVAYGEMEYKLVL---LVNEAIMYGAYMLGQS 1019
+Y L + + + G + GE+ +L + E++ G+Y+
Sbjct: 370 DLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESV--GSYVQTLV 427
Query: 1020 LVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQ 1079
+Y L+ A ++ S + RQP + + + G +DV F YP RP +
Sbjct: 428 YIYGDMLSNVGAA-EKVFSYMDRQPNLPSPGTLAPT---TLQGVVKFQDVSFAYPNRPDR 483
Query: 1080 RVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRL 1139
VLKG+ + G+ ALVG +G GKST+ L Q P G + LD + I S L
Sbjct: 484 PVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLNQPTGGQVLLDEKPI-SQYEHCYL 542
Query: 1140 RRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAV-TEA 1198
Q+ V QEPVL S+ NIAYG + +++AAA+AA+ FI + + T+
Sbjct: 543 HSQVVSVGQEPVLFSGSVRNNIAYG--LQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDV 600
Query: 1199 LEKAAK 1204
EK ++
Sbjct: 601 GEKGSQ 606
>AK172812-1|BAD18782.1| 571|Homo sapiens protein ( Homo sapiens
cDNA FLJ23973 fis, clone HEP18305, highly similar to
ATP-binding cassette, sub-family B, member 6,
mitochondrial precursor. ).
Length = 571
Score = 218 bits (533), Expect = 9e-56
Identities = 145/410 (35%), Positives = 213/410 (51%), Gaps = 13/410 (3%)
Query: 216 MPFSVITSIALSNYQTKSSIREMESYSLAGK-QAEEILKSVRTIVAFGGENKEVERYRRL 274
M + +I ++ ++TK R M + A + +A + L + T+ + E+ EVERYR
Sbjct: 150 MSLYLTLTIVVTEWRTKFR-RAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREA 208
Query: 275 LEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVY 334
+ + K L N ++ +G G+ L F T+ L+
Sbjct: 209 IIKYQGLEWKSSASLVLLNQTQNLVI----GLGLLAGSLLCAY-FVTEQKLQVGDYVLFG 263
Query: 335 SILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPRRVVGDI 394
+ + +YM + + + ++F L++ E ++ L G R G I
Sbjct: 264 TYIIQLYMP---LNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPL-RFQKGRI 319
Query: 395 LLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVX 454
E+V F Y E L+ S V P + +ALVG SG GKST+L+LL YD +G +
Sbjct: 320 EFENVHFSYADGRET--LQDVSFTVMPEQTLALVGPSGAGKSTILRLLFLFYDISSGCIR 377
Query: 455 XXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDF 514
+ LRS +GVV Q+ VLF TI DNI G A +E++ A+ A HD
Sbjct: 378 IDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHDA 437
Query: 515 ISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAA 574
I P GY T +GERG LSGG+KQR+AIAR++L+ P ++LLDEATSALD +ER +QA+
Sbjct: 438 IMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQAS 497
Query: 575 LDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFY 624
L + RTTI V+HRLST+VNAD+I+ + G IVE+G HE L+ G Y
Sbjct: 498 LAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVY 547
Score = 98.3 bits (234), Expect = 2e-19
Identities = 86/306 (28%), Positives = 153/306 (50%), Gaps = 39/306 (12%)
Query: 916 NAMESAT-AIATEAVVSIKTVQSLGVETVFLQKFQDALKT-------ACVAVAYKTRWRG 967
N E+AT A A +++++ +TV+ E+ ++++++A+ + ++ + +
Sbjct: 172 NTQENATRARAVDSLLNFETVKYYNAESYEVERYREAIIKYQGLEWKSSASLVLLNQTQN 231
Query: 968 LVYGLGVYIPFMAYCSATVYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSL------V 1021
LV GLG+ + G++L AY E KL V + +++G Y++ +
Sbjct: 232 LVIGLGL-----------LAGSLLCAYFVTEQKLQ--VGDYVLFGTYIIQLYMPLNWFGT 278
Query: 1022 YAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRV 1081
Y + T + +++ + ++ + G + G +V F Y +
Sbjct: 279 YYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPLR--FQKGRIEFENVHFSYAD--GRET 334
Query: 1082 LKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRR 1141
L+ + + +T+ALVG SG GKSTIL+L FYD SG I +D +DI S +T LR
Sbjct: 335 LQDVSFTVMPEQTLALVGPSGAGKSTILRLLFLFYDISSGCIRIDGQDI-SQVTQASLRS 393
Query: 1142 QLGVVQQEPVLLDRSLAENIAYGDNNRKVTM--HEIVAAAKAANIHSFIVSLPKAV-TEA 1198
+GVV Q+ VL + ++A+NI YG +VT E+ AAA+AA IH I++ P+ T+
Sbjct: 394 HIGVVPQDTVLFNDTIADNIRYG----RVTAGNDEVEAAAQAAGIHDAIMAFPEGYRTQV 449
Query: 1199 LEKAAK 1204
E+ K
Sbjct: 450 GERGLK 455
Score = 59.3 bits (137), Expect = 9e-08
Identities = 32/66 (48%), Positives = 41/66 (62%), Gaps = 3/66 (4%)
Query: 1193 KAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHY---W 1249
+A+ +L K RT I +AHRLSTV +AD I VI G IVERG H L+S G Y W
Sbjct: 492 RAIQASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMW 551
Query: 1250 RMCRGQ 1255
++ +GQ
Sbjct: 552 QLQQGQ 557
>BT009918-1|AAP88920.1| 753|Homo sapiens ATP-binding cassette,
sub-family B (MDR/TAP), member 7 protein.
Length = 753
Score = 218 bits (532), Expect = 1e-55
Identities = 138/418 (33%), Positives = 215/418 (51%), Gaps = 11/418 (2%)
Query: 202 FPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAF 261
+ G Q L + ++A++ ++T+ I ++ + AG A + L + T+ F
Sbjct: 288 YKCGAQFALVTLGTLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYF 347
Query: 262 GGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDT 321
E E +RY L+ E K + L + +AI FS G ++
Sbjct: 348 NNERYEAQRYDGFLKTYETASLKSTSTLAM-------LNFGQSAI-FSVGLTAIMVLASQ 399
Query: 322 DSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKI-DSL 380
VG + + ++ + + F ++F L++ + +I D +
Sbjct: 400 GIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKV 459
Query: 381 QQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQ 440
L + ++V F Y KVL G S V G+ VA+VG SG GKST+++
Sbjct: 460 MASPLQITPQTATVAFDNVHFEYIEGQ--KVLSGISFEVPAGKKVAIVGGSGSGKSTIVR 517
Query: 441 LLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATRE 500
LL R Y+PQ GS+ LR ++GVV Q+ VLF TIY N+ G+ A+ E
Sbjct: 518 LLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPE 577
Query: 501 EIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEAT 560
E+ VA++A HD I +P+GYDT +GERG LSGG+KQR+AIAR++L++P V+L DEAT
Sbjct: 578 EVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEAT 637
Query: 561 SALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLM 618
S+LD +E + A+ RT+I ++HRLST+V+AD II +DQG + E+GTH L+
Sbjct: 638 SSLDSITEETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLL 695
Score = 93.1 bits (221), Expect = 6e-18
Identities = 51/127 (40%), Positives = 77/127 (60%), Gaps = 4/127 (3%)
Query: 1079 QRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPR 1138
Q+VL GI ++ AGK +A+VG SG GKSTI++L RFY+P G I L ++I+ +++
Sbjct: 486 QKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQD-VSLES 544
Query: 1139 LRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAV-TE 1197
LRR +GVV Q+ VL ++ N+ YG N + E+ A AK A +H I+ +P T+
Sbjct: 545 LRRAVGVVPQDAVLFHNTIYYNLLYG--NISASPEEVYAVAKLAGLHDAILRMPHGYDTQ 602
Query: 1198 ALEKAAK 1204
E+ K
Sbjct: 603 VGERGLK 609
Score = 56.8 bits (131), Expect = 5e-07
Identities = 27/51 (52%), Positives = 36/51 (70%)
Query: 1193 KAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVS 1243
+ + A++ K RT I IAHRLSTV DAD I V+D+GK+ ERGTH L++
Sbjct: 646 ETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLA 696
>BC006323-1|AAH06323.1| 753|Homo sapiens ATP-binding cassette,
sub-family B (MDR/TAP), member 7 protein.
Length = 753
Score = 218 bits (532), Expect = 1e-55
Identities = 138/418 (33%), Positives = 215/418 (51%), Gaps = 11/418 (2%)
Query: 202 FPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAF 261
+ G Q L + ++A++ ++T+ I ++ + AG A + L + T+ F
Sbjct: 288 YKCGAQFALVTLGTLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYF 347
Query: 262 GGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDT 321
E E +RY L+ E K + L + +AI FS G ++
Sbjct: 348 NNERYEAQRYDGFLKTYETASLKSTSTLAM-------LNFGQSAI-FSVGLTAIMVLASQ 399
Query: 322 DSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKI-DSL 380
VG + + ++ + + F ++F L++ + +I D +
Sbjct: 400 GIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKV 459
Query: 381 QQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQ 440
L + ++V F Y KVL G S V G+ VA+VG SG GKST+++
Sbjct: 460 MASPLQITPQTATVAFDNVHFEYIEGQ--KVLSGISFEVPAGKKVAIVGGSGSGKSTIVR 517
Query: 441 LLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATRE 500
LL R Y+PQ GS+ LR ++GVV Q+ VLF TIY N+ G+ A+ E
Sbjct: 518 LLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPE 577
Query: 501 EIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEAT 560
E+ VA++A HD I +P+GYDT +GERG LSGG+KQR+AIAR++L++P V+L DEAT
Sbjct: 578 EVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEAT 637
Query: 561 SALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLM 618
S+LD +E + A+ RT+I ++HRLST+V+AD II +DQG + E+GTH L+
Sbjct: 638 SSLDSITEETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLL 695
Score = 93.1 bits (221), Expect = 6e-18
Identities = 51/127 (40%), Positives = 77/127 (60%), Gaps = 4/127 (3%)
Query: 1079 QRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPR 1138
Q+VL GI ++ AGK +A+VG SG GKSTI++L RFY+P G I L ++I+ +++
Sbjct: 486 QKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQD-VSLES 544
Query: 1139 LRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAV-TE 1197
LRR +GVV Q+ VL ++ N+ YG N + E+ A AK A +H I+ +P T+
Sbjct: 545 LRRAVGVVPQDAVLFHNTIYYNLLYG--NISASPEEVYAVAKLAGLHDAILRMPHGYDTQ 602
Query: 1198 ALEKAAK 1204
E+ K
Sbjct: 603 VGERGLK 609
Score = 56.8 bits (131), Expect = 5e-07
Identities = 27/51 (52%), Positives = 36/51 (70%)
Query: 1193 KAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVS 1243
+ + A++ K RT I IAHRLSTV DAD I V+D+GK+ ERGTH L++
Sbjct: 646 ETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLA 696
>AL360179-2|CAH70565.1| 752|Homo sapiens ATP-binding cassette,
sub-family B (MDR/TAP), member 7 protein.
Length = 752
Score = 218 bits (532), Expect = 1e-55
Identities = 138/418 (33%), Positives = 215/418 (51%), Gaps = 11/418 (2%)
Query: 202 FPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAF 261
+ G Q L + ++A++ ++T+ I ++ + AG A + L + T+ F
Sbjct: 287 YKCGAQFALVTLGTLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYF 346
Query: 262 GGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDT 321
E E +RY L+ E K + L + +AI FS G ++
Sbjct: 347 NNERYEAQRYDGFLKTYETASLKSTSTLAM-------LNFGQSAI-FSVGLTAIMVLASQ 398
Query: 322 DSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKI-DSL 380
VG + + ++ + + F ++F L++ + +I D +
Sbjct: 399 GIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKV 458
Query: 381 QQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQ 440
L + ++V F Y KVL G S V G+ VA+VG SG GKST+++
Sbjct: 459 MASPLQITPQTATVAFDNVHFEYIEGQ--KVLSGISFEVPAGKKVAIVGGSGSGKSTIVR 516
Query: 441 LLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATRE 500
LL R Y+PQ GS+ LR ++GVV Q+ VLF TIY N+ G+ A+ E
Sbjct: 517 LLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPE 576
Query: 501 EIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEAT 560
E+ VA++A HD I +P+GYDT +GERG LSGG+KQR+AIAR++L++P V+L DEAT
Sbjct: 577 EVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEAT 636
Query: 561 SALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLM 618
S+LD +E + A+ RT+I ++HRLST+V+AD II +DQG + E+GTH L+
Sbjct: 637 SSLDSITEETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLL 694
Score = 93.1 bits (221), Expect = 6e-18
Identities = 51/127 (40%), Positives = 77/127 (60%), Gaps = 4/127 (3%)
Query: 1079 QRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPR 1138
Q+VL GI ++ AGK +A+VG SG GKSTI++L RFY+P G I L ++I+ +++
Sbjct: 485 QKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQD-VSLES 543
Query: 1139 LRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAV-TE 1197
LRR +GVV Q+ VL ++ N+ YG N + E+ A AK A +H I+ +P T+
Sbjct: 544 LRRAVGVVPQDAVLFHNTIYYNLLYG--NISASPEEVYAVAKLAGLHDAILRMPHGYDTQ 601
Query: 1198 ALEKAAK 1204
E+ K
Sbjct: 602 VGERGLK 608
Score = 56.8 bits (131), Expect = 5e-07
Identities = 27/51 (52%), Positives = 36/51 (70%)
Query: 1193 KAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVS 1243
+ + A++ K RT I IAHRLSTV DAD I V+D+GK+ ERGTH L++
Sbjct: 645 ETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLA 695
>AL360179-1|CAH70564.1| 753|Homo sapiens ATP-binding cassette,
sub-family B (MDR/TAP), member 7 protein.
Length = 753
Score = 218 bits (532), Expect = 1e-55
Identities = 138/418 (33%), Positives = 215/418 (51%), Gaps = 11/418 (2%)
Query: 202 FPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAF 261
+ G Q L + ++A++ ++T+ I ++ + AG A + L + T+ F
Sbjct: 288 YKCGAQFALVTLGTLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYF 347
Query: 262 GGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDT 321
E E +RY L+ E K + L + +AI FS G ++
Sbjct: 348 NNERYEAQRYDGFLKTYETASLKSTSTLAM-------LNFGQSAI-FSVGLTAIMVLASQ 399
Query: 322 DSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKI-DSL 380
VG + + ++ + + F ++F L++ + +I D +
Sbjct: 400 GIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKV 459
Query: 381 QQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQ 440
L + ++V F Y KVL G S V G+ VA+VG SG GKST+++
Sbjct: 460 MASPLQITPQTATVAFDNVHFEYIEGQ--KVLSGISFEVPAGKKVAIVGGSGSGKSTIVR 517
Query: 441 LLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATRE 500
LL R Y+PQ GS+ LR ++GVV Q+ VLF TIY N+ G+ A+ E
Sbjct: 518 LLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPE 577
Query: 501 EIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEAT 560
E+ VA++A HD I +P+GYDT +GERG LSGG+KQR+AIAR++L++P V+L DEAT
Sbjct: 578 EVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEAT 637
Query: 561 SALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLM 618
S+LD +E + A+ RT+I ++HRLST+V+AD II +DQG + E+GTH L+
Sbjct: 638 SSLDSITEETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLL 695
Score = 93.1 bits (221), Expect = 6e-18
Identities = 51/127 (40%), Positives = 77/127 (60%), Gaps = 4/127 (3%)
Query: 1079 QRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPR 1138
Q+VL GI ++ AGK +A+VG SG GKSTI++L RFY+P G I L ++I+ +++
Sbjct: 486 QKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQD-VSLES 544
Query: 1139 LRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAV-TE 1197
LRR +GVV Q+ VL ++ N+ YG N + E+ A AK A +H I+ +P T+
Sbjct: 545 LRRAVGVVPQDAVLFHNTIYYNLLYG--NISASPEEVYAVAKLAGLHDAILRMPHGYDTQ 602
Query: 1198 ALEKAAK 1204
E+ K
Sbjct: 603 VGERGLK 609
Score = 56.8 bits (131), Expect = 5e-07
Identities = 27/51 (52%), Positives = 36/51 (70%)
Query: 1193 KAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVS 1243
+ + A++ K RT I IAHRLSTV DAD I V+D+GK+ ERGTH L++
Sbjct: 646 ETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLA 696
>AL359545-2|CAI41573.1| 752|Homo sapiens ATP-binding cassette,
sub-family B (MDR/TAP), member 7 protein.
Length = 752
Score = 218 bits (532), Expect = 1e-55
Identities = 138/418 (33%), Positives = 215/418 (51%), Gaps = 11/418 (2%)
Query: 202 FPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAF 261
+ G Q L + ++A++ ++T+ I ++ + AG A + L + T+ F
Sbjct: 287 YKCGAQFALVTLGTLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYF 346
Query: 262 GGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDT 321
E E +RY L+ E K + L + +AI FS G ++
Sbjct: 347 NNERYEAQRYDGFLKTYETASLKSTSTLAM-------LNFGQSAI-FSVGLTAIMVLASQ 398
Query: 322 DSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKI-DSL 380
VG + + ++ + + F ++F L++ + +I D +
Sbjct: 399 GIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKV 458
Query: 381 QQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQ 440
L + ++V F Y KVL G S V G+ VA+VG SG GKST+++
Sbjct: 459 MASPLQITPQTATVAFDNVHFEYIEGQ--KVLSGISFEVPAGKKVAIVGGSGSGKSTIVR 516
Query: 441 LLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATRE 500
LL R Y+PQ GS+ LR ++GVV Q+ VLF TIY N+ G+ A+ E
Sbjct: 517 LLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPE 576
Query: 501 EIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEAT 560
E+ VA++A HD I +P+GYDT +GERG LSGG+KQR+AIAR++L++P V+L DEAT
Sbjct: 577 EVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEAT 636
Query: 561 SALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLM 618
S+LD +E + A+ RT+I ++HRLST+V+AD II +DQG + E+GTH L+
Sbjct: 637 SSLDSITEETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLL 694
Score = 93.1 bits (221), Expect = 6e-18
Identities = 51/127 (40%), Positives = 77/127 (60%), Gaps = 4/127 (3%)
Query: 1079 QRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPR 1138
Q+VL GI ++ AGK +A+VG SG GKSTI++L RFY+P G I L ++I+ +++
Sbjct: 485 QKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQD-VSLES 543
Query: 1139 LRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAV-TE 1197
LRR +GVV Q+ VL ++ N+ YG N + E+ A AK A +H I+ +P T+
Sbjct: 544 LRRAVGVVPQDAVLFHNTIYYNLLYG--NISASPEEVYAVAKLAGLHDAILRMPHGYDTQ 601
Query: 1198 ALEKAAK 1204
E+ K
Sbjct: 602 VGERGLK 608
Score = 56.8 bits (131), Expect = 5e-07
Identities = 27/51 (52%), Positives = 36/51 (70%)
Query: 1193 KAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVS 1243
+ + A++ K RT I IAHRLSTV DAD I V+D+GK+ ERGTH L++
Sbjct: 645 ETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLA 695
>AL359545-1|CAI41574.1| 753|Homo sapiens ATP-binding cassette,
sub-family B (MDR/TAP), member 7 protein.
Length = 753
Score = 218 bits (532), Expect = 1e-55
Identities = 138/418 (33%), Positives = 215/418 (51%), Gaps = 11/418 (2%)
Query: 202 FPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAF 261
+ G Q L + ++A++ ++T+ I ++ + AG A + L + T+ F
Sbjct: 288 YKCGAQFALVTLGTLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYF 347
Query: 262 GGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDT 321
E E +RY L+ E K + L + +AI FS G ++
Sbjct: 348 NNERYEAQRYDGFLKTYETASLKSTSTLAM-------LNFGQSAI-FSVGLTAIMVLASQ 399
Query: 322 DSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKI-DSL 380
VG + + ++ + + F ++F L++ + +I D +
Sbjct: 400 GIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKV 459
Query: 381 QQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQ 440
L + ++V F Y KVL G S V G+ VA+VG SG GKST+++
Sbjct: 460 MASPLQITPQTATVAFDNVHFEYIEGQ--KVLSGISFEVPAGKKVAIVGGSGSGKSTIVR 517
Query: 441 LLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATRE 500
LL R Y+PQ GS+ LR ++GVV Q+ VLF TIY N+ G+ A+ E
Sbjct: 518 LLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPE 577
Query: 501 EIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEAT 560
E+ VA++A HD I +P+GYDT +GERG LSGG+KQR+AIAR++L++P V+L DEAT
Sbjct: 578 EVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEAT 637
Query: 561 SALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLM 618
S+LD +E + A+ RT+I ++HRLST+V+AD II +DQG + E+GTH L+
Sbjct: 638 SSLDSITEETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLL 695
Score = 93.1 bits (221), Expect = 6e-18
Identities = 51/127 (40%), Positives = 77/127 (60%), Gaps = 4/127 (3%)
Query: 1079 QRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPR 1138
Q+VL GI ++ AGK +A+VG SG GKSTI++L RFY+P G I L ++I+ +++
Sbjct: 486 QKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQD-VSLES 544
Query: 1139 LRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAV-TE 1197
LRR +GVV Q+ VL ++ N+ YG N + E+ A AK A +H I+ +P T+
Sbjct: 545 LRRAVGVVPQDAVLFHNTIYYNLLYG--NISASPEEVYAVAKLAGLHDAILRMPHGYDTQ 602
Query: 1198 ALEKAAK 1204
E+ K
Sbjct: 603 VGERGLK 609
Score = 56.8 bits (131), Expect = 5e-07
Identities = 27/51 (52%), Positives = 36/51 (70%)
Query: 1193 KAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVS 1243
+ + A++ K RT I IAHRLSTV DAD I V+D+GK+ ERGTH L++
Sbjct: 646 ETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLA 696
>AF241887-1|AAK20173.1| 752|Homo sapiens ATP binding cassette 7
protein.
Length = 752
Score = 218 bits (532), Expect = 1e-55
Identities = 138/418 (33%), Positives = 215/418 (51%), Gaps = 11/418 (2%)
Query: 202 FPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAF 261
+ G Q L + ++A++ ++T+ I ++ + AG A + L + T+ F
Sbjct: 287 YKCGAQFALVTLGTLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYF 346
Query: 262 GGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDT 321
E E +RY L+ E K + L + +AI FS G ++
Sbjct: 347 NNERYEAQRYDGFLKTYETASLKSTSTLAM-------LNFGQSAI-FSVGLTAIMVLASQ 398
Query: 322 DSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKI-DSL 380
VG + + ++ + + F ++F L++ + +I D +
Sbjct: 399 GIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKV 458
Query: 381 QQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQ 440
L + ++V F Y KVL G S V G+ VA+VG SG GKST+++
Sbjct: 459 MASPLQITPQTATVAFDNVHFEYIEGQ--KVLSGISFEVPAGKKVAIVGGSGSGKSTIVR 516
Query: 441 LLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATRE 500
LL R Y+PQ GS+ LR ++GVV Q+ VLF TIY N+ G+ A+ E
Sbjct: 517 LLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPE 576
Query: 501 EIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEAT 560
E+ VA++A HD I +P+GYDT +GERG LSGG+KQR+AIAR++L++P V+L DEAT
Sbjct: 577 EVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEAT 636
Query: 561 SALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLM 618
S+LD +E + A+ RT+I ++HRLST+V+AD II +DQG + E+GTH L+
Sbjct: 637 SSLDSITEETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLL 694
Score = 93.1 bits (221), Expect = 6e-18
Identities = 51/127 (40%), Positives = 77/127 (60%), Gaps = 4/127 (3%)
Query: 1079 QRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPR 1138
Q+VL GI ++ AGK +A+VG SG GKSTI++L RFY+P G I L ++I+ +++
Sbjct: 485 QKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQD-VSLES 543
Query: 1139 LRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAV-TE 1197
LRR +GVV Q+ VL ++ N+ YG N + E+ A AK A +H I+ +P T+
Sbjct: 544 LRRAVGVVPQDAVLFHNTIYYNLLYG--NISASPEEVYAVAKLAGLHDAILRMPHGYDTQ 601
Query: 1198 ALEKAAK 1204
E+ K
Sbjct: 602 VGERGLK 608
Score = 56.8 bits (131), Expect = 5e-07
Identities = 27/51 (52%), Positives = 36/51 (70%)
Query: 1193 KAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVS 1243
+ + A++ K RT I IAHRLSTV DAD I V+D+GK+ ERGTH L++
Sbjct: 645 ETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLA 695
>AF133659-1|AAD33045.1| 752|Homo sapiens ATP-binding cassette 7
iron transporter protein.
Length = 752
Score = 218 bits (532), Expect = 1e-55
Identities = 138/418 (33%), Positives = 215/418 (51%), Gaps = 11/418 (2%)
Query: 202 FPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAF 261
+ G Q L + ++A++ ++T+ I ++ + AG A + L + T+ F
Sbjct: 287 YKCGAQFALVTLGTLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYF 346
Query: 262 GGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDT 321
E E +RY L+ E K + L + +AI FS G ++
Sbjct: 347 NNERYEAQRYDGFLKTYETASLKSTSTLAM-------LNFGQSAI-FSVGLTAIMVLASQ 398
Query: 322 DSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKI-DSL 380
VG + + ++ + + F ++F L++ + +I D +
Sbjct: 399 GIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKV 458
Query: 381 QQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQ 440
L + ++V F Y KVL G S V G+ VA+VG SG GKST+++
Sbjct: 459 MASPLQITPQTATVAFDNVHFEYIEGQ--KVLSGISFEVPAGKKVAIVGGSGSGKSTIVR 516
Query: 441 LLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATRE 500
LL R Y+PQ GS+ LR ++GVV Q+ VLF TIY N+ G+ A+ E
Sbjct: 517 LLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPE 576
Query: 501 EIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEAT 560
E+ VA++A HD I +P+GYDT +GERG LSGG+KQR+AIAR++L++P V+L DEAT
Sbjct: 577 EVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEAT 636
Query: 561 SALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLM 618
S+LD +E + A+ RT+I ++HRLST+V+AD II +DQG + E+GTH L+
Sbjct: 637 SSLDSITEETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLL 694
Score = 93.1 bits (221), Expect = 6e-18
Identities = 51/127 (40%), Positives = 77/127 (60%), Gaps = 4/127 (3%)
Query: 1079 QRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPR 1138
Q+VL GI ++ AGK +A+VG SG GKSTI++L RFY+P G I L ++I+ +++
Sbjct: 485 QKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQD-VSLES 543
Query: 1139 LRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAV-TE 1197
LRR +GVV Q+ VL ++ N+ YG N + E+ A AK A +H I+ +P T+
Sbjct: 544 LRRAVGVVPQDAVLFHNTIYYNLLYG--NISASPEEVYAVAKLAGLHDAILRMPHGYDTQ 601
Query: 1198 ALEKAAK 1204
E+ K
Sbjct: 602 VGERGLK 608
Score = 56.8 bits (131), Expect = 5e-07
Identities = 27/51 (52%), Positives = 36/51 (70%)
Query: 1193 KAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVS 1243
+ + A++ K RT I IAHRLSTV DAD I V+D+GK+ ERGTH L++
Sbjct: 645 ETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLA 695
>AF078777-1|AAD47141.1| 748|Homo sapiens ABC transporter protein.
Length = 748
Score = 217 bits (530), Expect = 2e-55
Identities = 138/418 (33%), Positives = 215/418 (51%), Gaps = 11/418 (2%)
Query: 202 FPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAF 261
+ G Q L + ++A++ ++T+ I ++ + AG A + L + T+ F
Sbjct: 283 YKCGAQFALVTLGTLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYF 342
Query: 262 GGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDT 321
E E +RY L+ E K + L + +AI FS G ++
Sbjct: 343 NNERYEAQRYDGFLKTYETASLKSTSTLAM-------LNFGQSAI-FSVGLTAIMVLASQ 394
Query: 322 DSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKI-DSL 380
VG + + ++ + + F ++F L++ + +I D +
Sbjct: 395 GIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKV 454
Query: 381 QQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQ 440
L + ++V F Y KVL G S V G+ VA+VG SG GKST+++
Sbjct: 455 MASPLQITPQTATVAFDNVHFEYIEGQ--KVLSGISFEVPAGKKVAIVGGSGSGKSTIVR 512
Query: 441 LLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATRE 500
LL R Y+PQ GS+ LR ++GVV Q+ VLF TIY N+ G+ A+ E
Sbjct: 513 LLFRFYEPQKGSIYLAGQNIQDVSLVSLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPE 572
Query: 501 EIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEAT 560
E+ VA++A HD I +P+GYDT +GERG LSGG+KQR+AIAR++L++P V+L DEAT
Sbjct: 573 EVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEAT 632
Query: 561 SALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLM 618
S+LD +E + A+ RT+I ++HRLST+V+AD II +DQG + E+GTH L+
Sbjct: 633 SSLDSITEETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLL 690
Score = 92.7 bits (220), Expect = 8e-18
Identities = 51/127 (40%), Positives = 77/127 (60%), Gaps = 4/127 (3%)
Query: 1079 QRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPR 1138
Q+VL GI ++ AGK +A+VG SG GKSTI++L RFY+P G I L ++I+ +++
Sbjct: 481 QKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQD-VSLVS 539
Query: 1139 LRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAV-TE 1197
LRR +GVV Q+ VL ++ N+ YG N + E+ A AK A +H I+ +P T+
Sbjct: 540 LRRAVGVVPQDAVLFHNTIYYNLLYG--NISASPEEVYAVAKLAGLHDAILRMPHGYDTQ 597
Query: 1198 ALEKAAK 1204
E+ K
Sbjct: 598 VGERGLK 604
Score = 56.8 bits (131), Expect = 5e-07
Identities = 27/51 (52%), Positives = 36/51 (70%)
Query: 1193 KAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVS 1243
+ + A++ K RT I IAHRLSTV DAD I V+D+GK+ ERGTH L++
Sbjct: 641 ETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLA 691
>AB112583-1|BAC98410.1| 681|Homo sapiens TAP-Like isoform 12C
protein.
Length = 681
Score = 216 bits (527), Expect = 5e-55
Identities = 136/433 (31%), Positives = 218/433 (50%), Gaps = 18/433 (4%)
Query: 140 RIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAV-VSNLVGTSVICL 198
R+R RS++ Q+ S++D + +L S+++ + + + + + + V + N V + + +
Sbjct: 260 RLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVV 319
Query: 199 CTAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTI 258
F L WQL+L P ++ S Y + S + + A AEE + +++T+
Sbjct: 320 FM-FSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTV 378
Query: 259 VAFGGENKEVERYRRLLEPAEEFGRKRG---LFTGLGNGFNWVLTYSLNAIGFSYGTRLV 315
+F E +E E Y R L+ + RK ++ G+G +L ++ + YG LV
Sbjct: 379 RSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLT-LLVVQVSIL--YYGGHLV 435
Query: 316 VNDFDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREP 375
++ T NL + +Y + M + + G +F I+R+P
Sbjct: 436 ISGQMTSGNLIAF---IIYEFVLGDCMESVGSVY-----SGLMQGVGAAEKVFEFIDRQP 487
Query: 376 KIDSLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGK 435
+ + L P + G + E+V F Y +RP +VL+ S + PG+ ALVG SG GK
Sbjct: 488 TM--VHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGK 545
Query: 436 STVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSP 495
S+ + +L+ Y + G V +L + +V QEPVLF +I DNI+ G P
Sbjct: 546 SSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLP 605
Query: 496 EATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLL 555
E + A+ A AH FI L +GY T GE+GA LSGGQKQR+A+AR+L+R P VL+
Sbjct: 606 TVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLI 665
Query: 556 LDEATSALDPHSE 568
LDEATSALD SE
Sbjct: 666 LDEATSALDAESE 678
Score = 165 bits (402), Expect = 7e-40
Identities = 133/435 (30%), Positives = 205/435 (47%), Gaps = 26/435 (5%)
Query: 781 DLYSVLFVVIAAVA-GISMC--LQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETN 837
D +S V++ +A G S ++ FT ++ RLR+ F SL+ QE FFD+ N
Sbjct: 223 DQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDE--N 280
Query: 838 TVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLMV 897
G + +RL+ DT V I + L+ V + S +W+L+LV + P+++
Sbjct: 281 RTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIM 340
Query: 898 GSIWLEGIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVET----VFLQKFQDALK 953
+ G ++ + +NA+ A+ A E + ++KTV+S E V+L+K Q K
Sbjct: 341 MVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYK 400
Query: 954 -TACVAVAYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEY-KLVLLVNEAIMY 1011
A AY V+G G+ + + S YG LV G+M L+ + +
Sbjct: 401 LNRKEAAAYMY----YVWGSGLTL-LVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVL 455
Query: 1012 GAYMLGQSLVYAPSLNTAKACGARILSIIQRQPK-IHNAVGVKDKKDWVASGNFSMRDVE 1070
G M VY+ L ++ I RQP +H+ D + G +V
Sbjct: 456 GDCMESVGSVYS-GLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLE----GRVDFENVT 510
Query: 1071 FCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDI 1130
F Y TRP +VL+ + + GK ALVG SG GKS+ + + + FY + G + LD + I
Sbjct: 511 FTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPI 570
Query: 1131 RSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVS 1190
SA L R + +V QEPVL RS+ +NI+YG V +V AA+ AN H FI+
Sbjct: 571 -SAYDHKYLHRVISLVSQEPVLFARSITDNISYG--LPTVPFEMVVEAAQKANAHGFIME 627
Query: 1191 LPKAV-TEALEKAAK 1204
L TE EK A+
Sbjct: 628 LQDGYSTETGEKGAQ 642
>AB112582-1|BAC98409.1| 683|Homo sapiens TAP-Like isoform 12B
protein.
Length = 683
Score = 216 bits (527), Expect = 5e-55
Identities = 136/433 (31%), Positives = 218/433 (50%), Gaps = 18/433 (4%)
Query: 140 RIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAV-VSNLVGTSVICL 198
R+R RS++ Q+ S++D + +L S+++ + + + + + + V + N V + + +
Sbjct: 260 RLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVV 319
Query: 199 CTAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTI 258
F L WQL+L P ++ S Y + S + + A AEE + +++T+
Sbjct: 320 FM-FSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTV 378
Query: 259 VAFGGENKEVERYRRLLEPAEEFGRKRG---LFTGLGNGFNWVLTYSLNAIGFSYGTRLV 315
+F E +E E Y R L+ + RK ++ G+G +L ++ + YG LV
Sbjct: 379 RSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLT-LLVVQVSIL--YYGGHLV 435
Query: 316 VNDFDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREP 375
++ T NL + +Y + M + + G +F I+R+P
Sbjct: 436 ISGQMTSGNLIAF---IIYEFVLGDCMESVGSVY-----SGLMQGVGAAEKVFEFIDRQP 487
Query: 376 KIDSLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGK 435
+ + L P + G + E+V F Y +RP +VL+ S + PG+ ALVG SG GK
Sbjct: 488 TM--VHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGK 545
Query: 436 STVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSP 495
S+ + +L+ Y + G V +L + +V QEPVLF +I DNI+ G P
Sbjct: 546 SSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLP 605
Query: 496 EATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLL 555
E + A+ A AH FI L +GY T GE+GA LSGGQKQR+A+AR+L+R P VL+
Sbjct: 606 TVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLI 665
Query: 556 LDEATSALDPHSE 568
LDEATSALD SE
Sbjct: 666 LDEATSALDAESE 678
Score = 165 bits (402), Expect = 7e-40
Identities = 133/435 (30%), Positives = 205/435 (47%), Gaps = 26/435 (5%)
Query: 781 DLYSVLFVVIAAVA-GISMC--LQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETN 837
D +S V++ +A G S ++ FT ++ RLR+ F SL+ QE FFD+ N
Sbjct: 223 DQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDE--N 280
Query: 838 TVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLMV 897
G + +RL+ DT V I + L+ V + S +W+L+LV + P+++
Sbjct: 281 RTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIM 340
Query: 898 GSIWLEGIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVET----VFLQKFQDALK 953
+ G ++ + +NA+ A+ A E + ++KTV+S E V+L+K Q K
Sbjct: 341 MVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYK 400
Query: 954 -TACVAVAYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEY-KLVLLVNEAIMY 1011
A AY V+G G+ + + S YG LV G+M L+ + +
Sbjct: 401 LNRKEAAAYMY----YVWGSGLTL-LVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVL 455
Query: 1012 GAYMLGQSLVYAPSLNTAKACGARILSIIQRQPK-IHNAVGVKDKKDWVASGNFSMRDVE 1070
G M VY+ L ++ I RQP +H+ D + G +V
Sbjct: 456 GDCMESVGSVYS-GLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLE----GRVDFENVT 510
Query: 1071 FCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDI 1130
F Y TRP +VL+ + + GK ALVG SG GKS+ + + + FY + G + LD + I
Sbjct: 511 FTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPI 570
Query: 1131 RSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVS 1190
SA L R + +V QEPVL RS+ +NI+YG V +V AA+ AN H FI+
Sbjct: 571 -SAYDHKYLHRVISLVSQEPVLFARSITDNISYG--LPTVPFEMVVEAAQKANAHGFIME 627
Query: 1191 LPKAV-TEALEKAAK 1204
L TE EK A+
Sbjct: 628 LQDGYSTETGEKGAQ 642
>AB005289-1|BAA28861.1| 752|Homo sapiens ABC transporter 7 protein
protein.
Length = 752
Score = 214 bits (523), Expect = 1e-54
Identities = 137/418 (32%), Positives = 213/418 (50%), Gaps = 11/418 (2%)
Query: 202 FPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAF 261
+ G Q L + ++A++ + T+ I ++ + AG A + L + T+
Sbjct: 287 YKCGAQFALVTLGTLGTYTAFTVAVTRWGTRFRIEMNKADNDAGNAAIDSLLNYETVKYI 346
Query: 262 GGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDT 321
E E +RY L+ E K + L + +AI FS G ++
Sbjct: 347 NNERYEAQRYDGFLKTYETASLKSTSTLAM-------LNFGQSAI-FSVGLTAIMVLASQ 398
Query: 322 DSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKI-DSL 380
VG + + ++ + + F ++F L++ + +I D +
Sbjct: 399 GIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKV 458
Query: 381 QQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQ 440
L + ++V F Y KVL G S V G+ VA+VG SG GKST+++
Sbjct: 459 MASPLQITPQTATVAFDNVHFEYIEGQ--KVLSGISFEVPAGKKVAIVGGSGSGKSTIVR 516
Query: 441 LLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATRE 500
LL R Y+PQ GS+ LR ++GVV Q+ VLF TIY N+ G+ A+ E
Sbjct: 517 LLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPE 576
Query: 501 EIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEAT 560
E+ VA++A HD I +P+GYDT +GERG LSGG+KQR+AIAR++L++P V+L DEAT
Sbjct: 577 EVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEAT 636
Query: 561 SALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLM 618
S+LD +E + A+ RT+I ++HRLST+V+AD II +DQG + E+GTH L+
Sbjct: 637 SSLDSITEETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLL 694
Score = 93.1 bits (221), Expect = 6e-18
Identities = 51/127 (40%), Positives = 77/127 (60%), Gaps = 4/127 (3%)
Query: 1079 QRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPR 1138
Q+VL GI ++ AGK +A+VG SG GKSTI++L RFY+P G I L ++I+ +++
Sbjct: 485 QKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQD-VSLES 543
Query: 1139 LRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAV-TE 1197
LRR +GVV Q+ VL ++ N+ YG N + E+ A AK A +H I+ +P T+
Sbjct: 544 LRRAVGVVPQDAVLFHNTIYYNLLYG--NISASPEEVYAVAKLAGLHDAILRMPHGYDTQ 601
Query: 1198 ALEKAAK 1204
E+ K
Sbjct: 602 VGERGLK 608
Score = 56.8 bits (131), Expect = 5e-07
Identities = 27/51 (52%), Positives = 36/51 (70%)
Query: 1193 KAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVS 1243
+ + A++ K RT I IAHRLSTV DAD I V+D+GK+ ERGTH L++
Sbjct: 645 ETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLA 695
>U18237-1|AAA84438.1| 229|Homo sapiens ATP-binding cassette protein
protein.
Length = 229
Score = 212 bits (517), Expect = 8e-54
Identities = 116/221 (52%), Positives = 145/221 (65%), Gaps = 6/221 (2%)
Query: 413 KGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXS-WLRSS 471
K FS+ + G ALVG SG GKSTVL LL RLYDP +G++ S WLRS
Sbjct: 2 KDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDNPSAKPSVWLRSK 61
Query: 472 LGVVGQEPVLFRGTIYDNIAIGSPE---ATREEIQRVAEIAYAHDFISLLPNGYDTVIGE 528
+G V QEP+LF +I +NIA G+ + T EEIQRVAE+A A P ++TV+GE
Sbjct: 62 IGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVASPEFPPR-FNTVVGE 120
Query: 529 RGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVS 588
+G LSGGQKQRIAIAR+LL+ P +LLLDEATSALD +E VQ ALDR GRT + ++
Sbjct: 121 KGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIA 180
Query: 589 HRLSTIVNADRIICMDQGVIVEQGTHEDLM-KAKGFYHKLV 628
H LSTI NA+ + +DQG I E G HE+L+ K G Y KL+
Sbjct: 181 HSLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLM 221
Score = 92.3 bits (219), Expect = 1e-17
Identities = 51/102 (50%), Positives = 60/102 (58%), Gaps = 1/102 (0%)
Query: 1083 KGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQ 1142
K L + +G ALVG SG GKST+L L R YDP SG I LD D SA LR +
Sbjct: 2 KDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDNPSAKPSVWLRSK 61
Query: 1143 LGVVQQEPVLLDRSLAENIAYG-DNNRKVTMHEIVAAAKAAN 1183
+G V QEP+L S+AENIAYG D+ VT EI A+ AN
Sbjct: 62 IGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVAN 103
Score = 60.9 bits (141), Expect = 3e-08
Identities = 46/141 (32%), Positives = 71/141 (50%), Gaps = 15/141 (10%)
Query: 1117 DPDSGFIELDNR--DIRSALTIPRLRRQLG-VVQQEPVLLDRSLAENIAYG----DNNRK 1169
DP S E R ++ +A+ P + VV ++ VLL + IA N +
Sbjct: 86 DPSSVTAEEIQRVAEVANAVASPEFPPRFNTVVGEKGVLLSGGQKQRIAIARALLKNPKI 145
Query: 1170 VTMHEIVAAAKAANIHSFIVSLPKAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDK 1229
+ + E +A A N + V EAL++ GRT + IAH LST+K+A+++ V+D+
Sbjct: 146 LLLDEATSALDAENEY--------LVQEALDRLMDGRTVLVIAHSLSTIKNANMVAVLDQ 197
Query: 1230 GKIVERGTHAELVSMKGHYWR 1250
GKI E G H EL+S +R
Sbjct: 198 GKITEYGKHEELLSKPNGIYR 218
>AF176984-1|AAD50509.1| 372|Homo sapiens TAP2 protein protein.
Length = 372
Score = 211 bits (515), Expect = 1e-53
Identities = 128/373 (34%), Positives = 200/373 (53%), Gaps = 13/373 (3%)
Query: 235 IREME-SYSLAGKQAEEILKSVRTIVAFGGENKEVERYRRLLEPAEEFGRKRGLFTGLGN 293
+RE++ + + AG+ E + ++T+ +FG E EV RY+ LE + +R L L
Sbjct: 3 LREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYL 62
Query: 294 GFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPH 353
VL + + S G + + + T +L + +Y Y+ Q++ +
Sbjct: 63 LVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSF---MIYQESVGSYV--QTLVYIYGD 117
Query: 354 LEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLK 413
+ +F ++R+P + S L P + G + +DV F YP+RP+ VLK
Sbjct: 118 M---LSNVGAAEKVFSYMDRQPNLPS--PGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLK 172
Query: 414 GFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLG 473
G + ++PGE ALVG +G GKSTV LLQ LY P G V +L S +
Sbjct: 173 GLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVV 232
Query: 474 VVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASL 533
VGQEPVLF G++ +NIA G +++ A+ A+A DFI + +G T +GE+G+ L
Sbjct: 233 SVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQL 292
Query: 534 SGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHRLST 593
+ GQKQR+AIAR+L+R+P VL+LDEATSALD E+ +Q R RT + ++HRL T
Sbjct: 293 AAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQDWNSRGD--RTVLVIAHRLQT 350
Query: 594 IVNADRIICMDQG 606
+ A +I+ + +G
Sbjct: 351 VQRAHQILVLQEG 363
Score = 101 bits (243), Expect = 1e-20
Identities = 84/295 (28%), Positives = 142/295 (48%), Gaps = 15/295 (5%)
Query: 915 RNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVAYKTRWRGLVYGLGV 974
++A+ A + EAV ++TV+S G E + ++++AL+ C + ++ +Y L
Sbjct: 7 QDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQ-CRQLYWRRDLERALYLLVR 65
Query: 975 YIPFMAYCSATVY-GAVLVAYGEMEYKLVL---LVNEAIMYGAYMLGQSLVYAPSLNTAK 1030
+ + + G + GE+ +L + E++ G+Y+ +Y L+
Sbjct: 66 RVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESV--GSYVQTLVYIYGDMLSNVG 123
Query: 1031 ACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKME 1090
A ++ S + RQP + + + G +DV F YP RP + VLKG+ +
Sbjct: 124 AA-EKVFSYMDRQPNLPSPGTLAPT---TLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLR 179
Query: 1091 AGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEP 1150
G+ ALVG +G GKST+ L Q Y P G + LD + I S L Q+ V QEP
Sbjct: 180 PGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPI-SQYEHCYLHSQVVSVGQEP 238
Query: 1151 VLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAV-TEALEKAAK 1204
VL S+ NIAYG + +++AAA+AA+ FI + + T+ EK ++
Sbjct: 239 VLFSGSVRNNIAYG--LQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQ 291
>AF105151-1|AAD12059.1| 653|Homo sapiens Tap2 transporter isoform
protein.
Length = 653
Score = 209 bits (510), Expect = 5e-53
Identities = 137/431 (31%), Positives = 218/431 (50%), Gaps = 12/431 (2%)
Query: 140 RIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLC 199
RIR S+LRQD+ ++ L S++S + + + V+ + V
Sbjct: 224 RIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYG 283
Query: 200 TAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREME-SYSLAGKQAEEILKSVRTI 258
+ +LTL MPF++ + N + + +RE++ + + AG+ E + ++T+
Sbjct: 284 FMLSISPRLTLLSLLHMPFTIAAE-KVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTV 342
Query: 259 VAFGGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVND 318
+FG E EV RY+ LE + +R L L VL + + S G + + +
Sbjct: 343 RSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLIRRVLHLGVQMLMLSCGLQQMQDG 402
Query: 319 FDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKID 378
T +L + +Y Y+ Q++ + + +F ++R+P +
Sbjct: 403 ELTQGSLLSF---MIYQESVGSYV--QTLVYIYGDM---LSNVGAAEKVFSYMDRQPNLP 454
Query: 379 SLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTV 438
S L P + G + +DV F YP+RP+ VLKG + ++PGE ALVG +G GKSTV
Sbjct: 455 S--PGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV 512
Query: 439 LQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEAT 498
LLQ LY P G V +L S + VGQEPVLF G++ +NIA G
Sbjct: 513 AALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE 572
Query: 499 REEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 558
+++ A+ A+A DFI + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDE
Sbjct: 573 DDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDE 632
Query: 559 ATSALDPHSER 569
ATSALD E+
Sbjct: 633 ATSALDVQCEQ 643
Score = 157 bits (382), Expect = 2e-37
Identities = 138/485 (28%), Positives = 233/485 (48%), Gaps = 24/485 (4%)
Query: 727 WQLLKLNAPEWPLITVGSIAAFLQGACFPVFALLFGFSSGIFILDNRDDIIYLADLYSVL 786
W+LLKL+ P+ PL+ +AAF + L SG I D A ++
Sbjct: 139 WRLLKLSRPDLPLL----VAAFFFLVLAVLGETLIPHYSGRVIDILGGDFDPHAFASAIF 194
Query: 787 FVVIAAV-AGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICAR 845
F+ + + + +S + FT ++ R+R Q F+SLL+Q++GFF +ET T G + +R
Sbjct: 195 FMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFF-QETKT-GELNSR 252
Query: 846 LSGDTAEVQGATGLRIGLILQGISSVV--VGFLLAISYNWKLTLVATVFLPLMVGSIWLE 903
LS DT + L ++L+ + VV GF+L+IS +LTL++ + +P + + +
Sbjct: 253 LSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISP--RLTLLSLLHMPFTIAAEKVY 310
Query: 904 GIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVAYKT 963
Q+ + ++A+ A + EAV ++TV+S G E + ++++AL+ +
Sbjct: 311 NTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQCRQLYWRRD 370
Query: 964 RWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEYKLVL---LVNEAIMYGAYMLGQSL 1020
R L + + G + GE+ +L + E++ G+Y+
Sbjct: 371 LERALYLLIRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESV--GSYVQTLVY 428
Query: 1021 VYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQR 1080
+Y L+ A ++ S + RQP + + + G +DV F YP RP +
Sbjct: 429 IYGDMLSNVGAA-EKVFSYMDRQPNLPSPGTLAPT---TLQGVVKFQDVSFAYPNRPDRP 484
Query: 1081 VLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLR 1140
VLKG+ + G+ ALVG +G GKST+ L Q Y P G + LD + I S L
Sbjct: 485 VLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPI-SQYEHCYLH 543
Query: 1141 RQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAV-TEAL 1199
Q+ V QEPVL S+ NIAYG + +++AAA+AA+ FI + + T+
Sbjct: 544 SQVVSVGQEPVLFSGSVRNNIAYG--LQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVG 601
Query: 1200 EKAAK 1204
EK ++
Sbjct: 602 EKGSQ 606
>BX682530-5|CAI41936.1| 653|Homo sapiens transporter 2 ATP-binding
cassette sub-family B (MDR/TAP) protein.
Length = 653
Score = 208 bits (509), Expect = 7e-53
Identities = 137/431 (31%), Positives = 218/431 (50%), Gaps = 12/431 (2%)
Query: 140 RIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLC 199
RIR S+LRQD+ ++ L S++S + + + V+ + V
Sbjct: 224 RIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYG 283
Query: 200 TAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREME-SYSLAGKQAEEILKSVRTI 258
+ +LTL MPF++ + N + + +RE++ + + AG+ E + ++T+
Sbjct: 284 FMLSISPRLTLLSLLHMPFTIAAE-KVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTV 342
Query: 259 VAFGGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVND 318
+FG E EV RY+ LE + +R L L VL + + S G + + +
Sbjct: 343 RSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDG 402
Query: 319 FDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKID 378
T +L + +Y Y+ Q++ + + +F ++R+P +
Sbjct: 403 ELTQGSLLSF---MIYQESVGSYV--QTLVYIYGDM---LSNVGAAEKVFSYMDRQPNLP 454
Query: 379 SLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTV 438
S L P + G + +DV F YP+RP+ VLKG + ++PGE ALVG +G GKSTV
Sbjct: 455 S--PGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV 512
Query: 439 LQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEAT 498
LLQ LY P G V +L S + VGQEPVLF G++ +NIA G
Sbjct: 513 AALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE 572
Query: 499 REEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 558
+++ A+ A+A DFI + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDE
Sbjct: 573 DDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDE 632
Query: 559 ATSALDPHSER 569
ATSALD E+
Sbjct: 633 ATSALDVQCEQ 643
Score = 158 bits (383), Expect = 1e-37
Identities = 139/486 (28%), Positives = 238/486 (48%), Gaps = 26/486 (5%)
Query: 727 WQLLKLNAPEWPLITVGSIAAFLQGACFPVFALLFGFSSGIFILDNRDDIIYLADLYSVL 786
W+LLKL+ P+ PL+ +AAF + L SG I D A ++
Sbjct: 139 WRLLKLSRPDLPLL----VAAFFFLVLAVLGETLIPHYSGRVIDILGGDFDPHAFASAIF 194
Query: 787 FVVIAAV-AGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICAR 845
F+ + + + +S + FT ++ R+R Q F+SLL+Q++GFF +ET T G + +R
Sbjct: 195 FMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFF-QETKT-GELNSR 252
Query: 846 LSGDTAEVQGATGLRIGLILQGISSVV--VGFLLAISYNWKLTLVATVFLPLMVGSIWLE 903
LS DT + L ++L+ + VV GF+L+IS +LTL++ + +P + + +
Sbjct: 253 LSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISP--RLTLLSLLHMPFTIAAEKVY 310
Query: 904 GIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVAYKT 963
Q+ + ++A+ A + EAV ++TV+S G E + ++++AL+ C + ++
Sbjct: 311 NTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQ-CRQLYWRR 369
Query: 964 RWRGLVYGLGVYIPFMAYCSATVY-GAVLVAYGEMEYKLVL---LVNEAIMYGAYMLGQS 1019
+Y L + + + G + GE+ +L + E++ G+Y+
Sbjct: 370 DLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESV--GSYVQTLV 427
Query: 1020 LVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQ 1079
+Y L+ A ++ S + RQP + + + G +DV F YP RP +
Sbjct: 428 YIYGDMLSNVGAA-EKVFSYMDRQPNLPSPGTLAPT---TLQGVVKFQDVSFAYPNRPDR 483
Query: 1080 RVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRL 1139
VLKG+ + G+ ALVG +G GKST+ L Q Y P G + LD + I S L
Sbjct: 484 PVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPI-SQYEHCYL 542
Query: 1140 RRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAV-TEA 1198
Q+ V QEPVL S+ NIAYG + +++AAA+AA+ FI + + T+
Sbjct: 543 HSQVVSVGQEPVLFSGSVRNNIAYG--LQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDV 600
Query: 1199 LEKAAK 1204
EK ++
Sbjct: 601 GEKGSQ 606
>BX296564-5|CAI41937.1| 653|Homo sapiens transporter 2 ATP-binding
cassette sub-family B (MDR/TAP) protein.
Length = 653
Score = 208 bits (509), Expect = 7e-53
Identities = 137/431 (31%), Positives = 218/431 (50%), Gaps = 12/431 (2%)
Query: 140 RIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLC 199
RIR S+LRQD+ ++ L S++S + + + V+ + V
Sbjct: 224 RIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYG 283
Query: 200 TAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREME-SYSLAGKQAEEILKSVRTI 258
+ +LTL MPF++ + N + + +RE++ + + AG+ E + ++T+
Sbjct: 284 FMLSISPRLTLLSLLHMPFTIAAE-KVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTV 342
Query: 259 VAFGGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVND 318
+FG E EV RY+ LE + +R L L VL + + S G + + +
Sbjct: 343 RSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDG 402
Query: 319 FDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKID 378
T +L + +Y Y+ Q++ + + +F ++R+P +
Sbjct: 403 ELTQGSLLSF---MIYQESVGSYV--QTLVYIYGDM---LSNVGAAEKVFSYMDRQPNLP 454
Query: 379 SLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTV 438
S L P + G + +DV F YP+RP+ VLKG + ++PGE ALVG +G GKSTV
Sbjct: 455 S--PGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV 512
Query: 439 LQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEAT 498
LLQ LY P G V +L S + VGQEPVLF G++ +NIA G
Sbjct: 513 AALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE 572
Query: 499 REEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 558
+++ A+ A+A DFI + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDE
Sbjct: 573 DDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDE 632
Query: 559 ATSALDPHSER 569
ATSALD E+
Sbjct: 633 ATSALDVQCEQ 643
Score = 158 bits (383), Expect = 1e-37
Identities = 139/486 (28%), Positives = 238/486 (48%), Gaps = 26/486 (5%)
Query: 727 WQLLKLNAPEWPLITVGSIAAFLQGACFPVFALLFGFSSGIFILDNRDDIIYLADLYSVL 786
W+LLKL+ P+ PL+ +AAF + L SG I D A ++
Sbjct: 139 WRLLKLSRPDLPLL----VAAFFFLVLAVLGETLIPHYSGRVIDILGGDFDPHAFASAIF 194
Query: 787 FVVIAAV-AGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICAR 845
F+ + + + +S + FT ++ R+R Q F+SLL+Q++GFF +ET T G + +R
Sbjct: 195 FMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFF-QETKT-GELNSR 252
Query: 846 LSGDTAEVQGATGLRIGLILQGISSVV--VGFLLAISYNWKLTLVATVFLPLMVGSIWLE 903
LS DT + L ++L+ + VV GF+L+IS +LTL++ + +P + + +
Sbjct: 253 LSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISP--RLTLLSLLHMPFTIAAEKVY 310
Query: 904 GIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVAYKT 963
Q+ + ++A+ A + EAV ++TV+S G E + ++++AL+ C + ++
Sbjct: 311 NTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQ-CRQLYWRR 369
Query: 964 RWRGLVYGLGVYIPFMAYCSATVY-GAVLVAYGEMEYKLVL---LVNEAIMYGAYMLGQS 1019
+Y L + + + G + GE+ +L + E++ G+Y+
Sbjct: 370 DLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESV--GSYVQTLV 427
Query: 1020 LVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQ 1079
+Y L+ A ++ S + RQP + + + G +DV F YP RP +
Sbjct: 428 YIYGDMLSNVGAA-EKVFSYMDRQPNLPSPGTLAPT---TLQGVVKFQDVSFAYPNRPDR 483
Query: 1080 RVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRL 1139
VLKG+ + G+ ALVG +G GKST+ L Q Y P G + LD + I S L
Sbjct: 484 PVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPI-SQYEHCYL 542
Query: 1140 RRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAV-TEA 1198
Q+ V QEPVL S+ NIAYG + +++AAA+AA+ FI + + T+
Sbjct: 543 HSQVVSVGQEPVLFSGSVRNNIAYG--LQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDV 600
Query: 1199 LEKAAK 1204
EK ++
Sbjct: 601 GEKGSQ 606
>AL935043-1|CAI18621.1| 653|Homo sapiens transporter 2, ATP-binding
cassette, sub-family Budogene) protein.
Length = 653
Score = 208 bits (509), Expect = 7e-53
Identities = 137/431 (31%), Positives = 218/431 (50%), Gaps = 12/431 (2%)
Query: 140 RIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLC 199
RIR S+LRQD+ ++ L S++S + + + V+ + V
Sbjct: 224 RIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYG 283
Query: 200 TAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREME-SYSLAGKQAEEILKSVRTI 258
+ +LTL MPF++ + N + + +RE++ + + AG+ E + ++T+
Sbjct: 284 FMLSISPRLTLLSLLHMPFTIAAE-KVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTV 342
Query: 259 VAFGGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVND 318
+FG E EV RY+ LE + +R L L VL + + S G + + +
Sbjct: 343 RSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDG 402
Query: 319 FDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKID 378
T +L + +Y Y+ Q++ + + +F ++R+P +
Sbjct: 403 ELTQGSLLSF---MIYQESVGSYV--QTLVYIYGDM---LSNVGAAEKVFSYMDRQPNLP 454
Query: 379 SLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTV 438
S L P + G + +DV F YP+RP+ VLKG + ++PGE ALVG +G GKSTV
Sbjct: 455 S--PGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV 512
Query: 439 LQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEAT 498
LLQ LY P G V +L S + VGQEPVLF G++ +NIA G
Sbjct: 513 AALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE 572
Query: 499 REEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 558
+++ A+ A+A DFI + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDE
Sbjct: 573 DDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDE 632
Query: 559 ATSALDPHSER 569
ATSALD E+
Sbjct: 633 ATSALDVQCEQ 643
Score = 158 bits (383), Expect = 1e-37
Identities = 139/486 (28%), Positives = 238/486 (48%), Gaps = 26/486 (5%)
Query: 727 WQLLKLNAPEWPLITVGSIAAFLQGACFPVFALLFGFSSGIFILDNRDDIIYLADLYSVL 786
W+LLKL+ P+ PL+ +AAF + L SG I D A ++
Sbjct: 139 WRLLKLSRPDLPLL----VAAFFFLVLAVLGETLIPHYSGRVIDILGGDFDPHAFASAIF 194
Query: 787 FVVIAAV-AGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICAR 845
F+ + + + +S + FT ++ R+R Q F+SLL+Q++GFF +ET T G + +R
Sbjct: 195 FMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFF-QETKT-GELNSR 252
Query: 846 LSGDTAEVQGATGLRIGLILQGISSVV--VGFLLAISYNWKLTLVATVFLPLMVGSIWLE 903
LS DT + L ++L+ + VV GF+L+IS +LTL++ + +P + + +
Sbjct: 253 LSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISP--RLTLLSLLHMPFTIAAEKVY 310
Query: 904 GIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVAYKT 963
Q+ + ++A+ A + EAV ++TV+S G E + ++++AL+ C + ++
Sbjct: 311 NTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQ-CRQLYWRR 369
Query: 964 RWRGLVYGLGVYIPFMAYCSATVY-GAVLVAYGEMEYKLVL---LVNEAIMYGAYMLGQS 1019
+Y L + + + G + GE+ +L + E++ G+Y+
Sbjct: 370 DLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESV--GSYVQTLV 427
Query: 1020 LVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQ 1079
+Y L+ A ++ S + RQP + + + G +DV F YP RP +
Sbjct: 428 YIYGDMLSNVGAA-EKVFSYMDRQPNLPSPGTLAPT---TLQGVVKFQDVSFAYPNRPDR 483
Query: 1080 RVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRL 1139
VLKG+ + G+ ALVG +G GKST+ L Q Y P G + LD + I S L
Sbjct: 484 PVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPI-SQYEHCYL 542
Query: 1140 RRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAV-TEA 1198
Q+ V QEPVL S+ NIAYG + +++AAA+AA+ FI + + T+
Sbjct: 543 HSQVVSVGQEPVLFSGSVRNNIAYG--LQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDV 600
Query: 1199 LEKAAK 1204
EK ++
Sbjct: 601 GEKGSQ 606
>AL671681-7|CAI17710.1| 653|Homo sapiens transporter 2, ATP-binding
cassette, sub-family Bpha protein.
Length = 653
Score = 208 bits (509), Expect = 7e-53
Identities = 137/431 (31%), Positives = 218/431 (50%), Gaps = 12/431 (2%)
Query: 140 RIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLC 199
RIR S+LRQD+ ++ L S++S + + + V+ + V
Sbjct: 224 RIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYG 283
Query: 200 TAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREME-SYSLAGKQAEEILKSVRTI 258
+ +LTL MPF++ + N + + +RE++ + + AG+ E + ++T+
Sbjct: 284 FMLSISPRLTLLSLLHMPFTIAAE-KVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTV 342
Query: 259 VAFGGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVND 318
+FG E EV RY+ LE + +R L L VL + + S G + + +
Sbjct: 343 RSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDG 402
Query: 319 FDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKID 378
T +L + +Y Y+ Q++ + + +F ++R+P +
Sbjct: 403 ELTQGSLLSF---MIYQESVGSYV--QTLVYIYGDM---LSNVGAAEKVFSYMDRQPNLP 454
Query: 379 SLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTV 438
S L P + G + +DV F YP+RP+ VLKG + ++PGE ALVG +G GKSTV
Sbjct: 455 S--PGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV 512
Query: 439 LQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEAT 498
LLQ LY P G V +L S + VGQEPVLF G++ +NIA G
Sbjct: 513 AALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE 572
Query: 499 REEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 558
+++ A+ A+A DFI + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDE
Sbjct: 573 DDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDE 632
Query: 559 ATSALDPHSER 569
ATSALD E+
Sbjct: 633 ATSALDVQCEQ 643
Score = 158 bits (383), Expect = 1e-37
Identities = 139/486 (28%), Positives = 238/486 (48%), Gaps = 26/486 (5%)
Query: 727 WQLLKLNAPEWPLITVGSIAAFLQGACFPVFALLFGFSSGIFILDNRDDIIYLADLYSVL 786
W+LLKL+ P+ PL+ +AAF + L SG I D A ++
Sbjct: 139 WRLLKLSRPDLPLL----VAAFFFLVLAVLGETLIPHYSGRVIDILGGDFDPHAFASAIF 194
Query: 787 FVVIAAV-AGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICAR 845
F+ + + + +S + FT ++ R+R Q F+SLL+Q++GFF +ET T G + +R
Sbjct: 195 FMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFF-QETKT-GELNSR 252
Query: 846 LSGDTAEVQGATGLRIGLILQGISSVV--VGFLLAISYNWKLTLVATVFLPLMVGSIWLE 903
LS DT + L ++L+ + VV GF+L+IS +LTL++ + +P + + +
Sbjct: 253 LSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISP--RLTLLSLLHMPFTIAAEKVY 310
Query: 904 GIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVAYKT 963
Q+ + ++A+ A + EAV ++TV+S G E + ++++AL+ C + ++
Sbjct: 311 NTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQ-CRQLYWRR 369
Query: 964 RWRGLVYGLGVYIPFMAYCSATVY-GAVLVAYGEMEYKLVL---LVNEAIMYGAYMLGQS 1019
+Y L + + + G + GE+ +L + E++ G+Y+
Sbjct: 370 DLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESV--GSYVQTLV 427
Query: 1020 LVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQ 1079
+Y L+ A ++ S + RQP + + + G +DV F YP RP +
Sbjct: 428 YIYGDMLSNVGAA-EKVFSYMDRQPNLPSPGTLAPT---TLQGVVKFQDVSFAYPNRPDR 483
Query: 1080 RVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRL 1139
VLKG+ + G+ ALVG +G GKST+ L Q Y P G + LD + I S L
Sbjct: 484 PVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPI-SQYEHCYL 542
Query: 1140 RRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAV-TEA 1198
Q+ V QEPVL S+ NIAYG + +++AAA+AA+ FI + + T+
Sbjct: 543 HSQVVSVGQEPVLFSGSVRNNIAYG--LQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDV 600
Query: 1199 LEKAAK 1204
EK ++
Sbjct: 601 GEKGSQ 606
>AL669918-3|CAI18136.1| 653|Homo sapiens transporter 2, ATP-binding
cassette, sub-family Bunit 11 protein.
Length = 653
Score = 208 bits (509), Expect = 7e-53
Identities = 137/431 (31%), Positives = 218/431 (50%), Gaps = 12/431 (2%)
Query: 140 RIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLC 199
RIR S+LRQD+ ++ L S++S + + + V+ + V
Sbjct: 224 RIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYG 283
Query: 200 TAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREME-SYSLAGKQAEEILKSVRTI 258
+ +LTL MPF++ + N + + +RE++ + + AG+ E + ++T+
Sbjct: 284 FMLSISPRLTLLSLLHMPFTIAAE-KVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTV 342
Query: 259 VAFGGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVND 318
+FG E EV RY+ LE + +R L L VL + + S G + + +
Sbjct: 343 RSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDG 402
Query: 319 FDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKID 378
T +L + +Y Y+ Q++ + + +F ++R+P +
Sbjct: 403 ELTQGSLLSF---MIYQESVGSYV--QTLVYIYGDM---LSNVGAAEKVFSYMDRQPNLP 454
Query: 379 SLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTV 438
S L P + G + +DV F YP+RP+ VLKG + ++PGE ALVG +G GKSTV
Sbjct: 455 S--PGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV 512
Query: 439 LQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEAT 498
LLQ LY P G V +L S + VGQEPVLF G++ +NIA G
Sbjct: 513 AALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE 572
Query: 499 REEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 558
+++ A+ A+A DFI + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDE
Sbjct: 573 DDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDE 632
Query: 559 ATSALDPHSER 569
ATSALD E+
Sbjct: 633 ATSALDVQCEQ 643
Score = 158 bits (383), Expect = 1e-37
Identities = 139/486 (28%), Positives = 238/486 (48%), Gaps = 26/486 (5%)
Query: 727 WQLLKLNAPEWPLITVGSIAAFLQGACFPVFALLFGFSSGIFILDNRDDIIYLADLYSVL 786
W+LLKL+ P+ PL+ +AAF + L SG I D A ++
Sbjct: 139 WRLLKLSRPDLPLL----VAAFFFLVLAVLGETLIPHYSGRVIDILGGDFDPHAFASAIF 194
Query: 787 FVVIAAV-AGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICAR 845
F+ + + + +S + FT ++ R+R Q F+SLL+Q++GFF +ET T G + +R
Sbjct: 195 FMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFF-QETKT-GELNSR 252
Query: 846 LSGDTAEVQGATGLRIGLILQGISSVV--VGFLLAISYNWKLTLVATVFLPLMVGSIWLE 903
LS DT + L ++L+ + VV GF+L+IS +LTL++ + +P + + +
Sbjct: 253 LSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISP--RLTLLSLLHMPFTIAAEKVY 310
Query: 904 GIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVAYKT 963
Q+ + ++A+ A + EAV ++TV+S G E + ++++AL+ C + ++
Sbjct: 311 NTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQ-CRQLYWRR 369
Query: 964 RWRGLVYGLGVYIPFMAYCSATVY-GAVLVAYGEMEYKLVL---LVNEAIMYGAYMLGQS 1019
+Y L + + + G + GE+ +L + E++ G+Y+
Sbjct: 370 DLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESV--GSYVQTLV 427
Query: 1020 LVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQ 1079
+Y L+ A ++ S + RQP + + + G +DV F YP RP +
Sbjct: 428 YIYGDMLSNVGAA-EKVFSYMDRQPNLPSPGTLAPT---TLQGVVKFQDVSFAYPNRPDR 483
Query: 1080 RVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRL 1139
VLKG+ + G+ ALVG +G GKST+ L Q Y P G + LD + I S L
Sbjct: 484 PVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPI-SQYEHCYL 542
Query: 1140 RRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAV-TEA 1198
Q+ V QEPVL S+ NIAYG + +++AAA+AA+ FI + + T+
Sbjct: 543 HSQVVSVGQEPVLFSGSVRNNIAYG--LQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDV 600
Query: 1199 LEKAAK 1204
EK ++
Sbjct: 601 GEKGSQ 606
>AF078671-1|AAD31384.1| 653|Homo sapiens transporter 2 isoform
protein.
Length = 653
Score = 208 bits (509), Expect = 7e-53
Identities = 137/431 (31%), Positives = 218/431 (50%), Gaps = 12/431 (2%)
Query: 140 RIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLC 199
RIR S+LRQD+ ++ L S++S + + + V+ + V
Sbjct: 224 RIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYG 283
Query: 200 TAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREME-SYSLAGKQAEEILKSVRTI 258
+ +LTL MPF++ + N + + +RE++ + + AG+ E + ++T+
Sbjct: 284 FMLSISPRLTLLSLLHMPFTIAAE-KVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTV 342
Query: 259 VAFGGENKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVND 318
+FG E EV RY+ LE + +R L L VL + + S G + + +
Sbjct: 343 RSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDG 402
Query: 319 FDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKID 378
T +L + +Y Y+ Q++ + + +F ++R+P +
Sbjct: 403 ELTQGSLLSF---MIYQESVGSYV--QTLVYIYGDM---LSNVGAAEKVFSYMDRQPNLP 454
Query: 379 SLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTV 438
S L P + G + +DV F YP+RP+ VLKG + ++PGE ALVG +G GKSTV
Sbjct: 455 S--PGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV 512
Query: 439 LQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEAT 498
LLQ LY P G V +L S + VGQEPVLF G++ +NIA G
Sbjct: 513 AALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE 572
Query: 499 REEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDE 558
+++ A+ A+A DFI + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDE
Sbjct: 573 DDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDE 632
Query: 559 ATSALDPHSER 569
ATSALD E+
Sbjct: 633 ATSALDVQCEQ 643
Score = 158 bits (383), Expect = 1e-37
Identities = 139/486 (28%), Positives = 238/486 (48%), Gaps = 26/486 (5%)
Query: 727 WQLLKLNAPEWPLITVGSIAAFLQGACFPVFALLFGFSSGIFILDNRDDIIYLADLYSVL 786
W+LLKL+ P+ PL+ +AAF + L SG I D A ++
Sbjct: 139 WRLLKLSRPDLPLL----VAAFFFLVLAVLGETLIPHYSGRVIDILGGDFDPHAFASAIF 194
Query: 787 FVVIAAV-AGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICAR 845
F+ + + + +S + FT ++ R+R Q F+SLL+Q++GFF +ET T G + +R
Sbjct: 195 FMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFF-QETKT-GELNSR 252
Query: 846 LSGDTAEVQGATGLRIGLILQGISSVV--VGFLLAISYNWKLTLVATVFLPLMVGSIWLE 903
LS DT + L ++L+ + VV GF+L+IS +LTL++ + +P + + +
Sbjct: 253 LSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISP--RLTLLSLLHMPFTIAAEKVY 310
Query: 904 GIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVAYKT 963
Q+ + ++A+ A + EAV ++TV+S G E + ++++AL+ C + ++
Sbjct: 311 NTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQ-CRQLYWRR 369
Query: 964 RWRGLVYGLGVYIPFMAYCSATVY-GAVLVAYGEMEYKLVL---LVNEAIMYGAYMLGQS 1019
+Y L + + + G + GE+ +L + E++ G+Y+
Sbjct: 370 DLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESV--GSYVQTLV 427
Query: 1020 LVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQ 1079
+Y L+ A ++ S + RQP + + + G +DV F YP RP +
Sbjct: 428 YIYGDMLSNVGAA-EKVFSYMDRQPNLPSPGTLAPT---TLQGVVKFQDVSFAYPNRPDR 483
Query: 1080 RVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRL 1139
VLKG+ + G+ ALVG +G GKST+ L Q Y P G + LD + I S L
Sbjct: 484 PVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPI-SQYEHCYL 542
Query: 1140 RRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAV-TEA 1198
Q+ V QEPVL S+ NIAYG + +++AAA+AA+ FI + + T+
Sbjct: 543 HSQVVSVGQEPVLFSGSVRNNIAYG--LQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDV 600
Query: 1199 LEKAAK 1204
EK ++
Sbjct: 601 GEKGSQ 606
>AF087138-1|AAC36724.1| 1581|Homo sapiens sulfonylurea receptor 1
protein.
Length = 1581
Score = 145 bits (352), Expect = 8e-34
Identities = 122/521 (23%), Positives = 237/521 (45%), Gaps = 21/521 (4%)
Query: 107 AMAIGMFISIGVSLVFCVLSFSLISWSALRQITRIRTLFLRSVLRQDMSWYDTDSEFNLA 166
AM + S+G+ V C+++ + W+ L+ R+ L ++ M +++T ++
Sbjct: 1064 AMVFTVLCSLGI--VLCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSIL 1121
Query: 167 SKMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPLGWQLTLACAAVMPFSVITSIAL 226
++ S + +I + + L +S ++++C+ + + + A++P +++
Sbjct: 1122 NRFSSDCNTIDQHIPSTLECLSR---STLLCVSALAVISYVTPVFLVALLPLAIVCYFIQ 1178
Query: 227 SNYQTKS-SIREMESYSLAGKQAE--EILKSVRTIVAFGGENKEVERYRRLLEPAEEFGR 283
++ S +++++ + + E ++ + TI AF E ++LLE +
Sbjct: 1179 KYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAF---RYEARFQQKLLEYTDS-NN 1234
Query: 284 KRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVYSILFSVYMA 343
LF N W L + IG V ++S R+ G V L M
Sbjct: 1235 IASLFLTAAN--RW-LEVRMEYIGACVVLIAAVTSI-SNSLHRELSAGLVGLGLTYALMV 1290
Query: 344 TQSITFCVPHLEGFXXXXXXXXSIFHLIEREPK-IDSLQQKGLTPRRVV--GDILLEDVE 400
+ + + V +L I L++ E + + L L P+ G I ++++
Sbjct: 1291 SNYLNWMVRNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLS 1350
Query: 401 FCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXX 460
Y S + VLK + + PG+ + + G +G GKS+ R+ D G +
Sbjct: 1351 VRYDSSLK-PVLKHVNALISPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDI 1409
Query: 461 XXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPN 520
LRS L ++ Q+PVLF GTI N+ + + + EIA + LP
Sbjct: 1410 AKLPLHTLRSRLSIILQDPVLFSGTIRFNLD-PERKCSDSTLWEALEIAQLKLVVKALPG 1468
Query: 521 GYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASV 580
G D +I E G + S GQ+Q +AR+ +R+ ++ ++DEAT+++D +E +Q + A
Sbjct: 1469 GLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFA 1528
Query: 581 GRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAK 621
RT +T++HR+ TI++AD +I + +G I+E E L+ K
Sbjct: 1529 DRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRK 1569
Score = 106 bits (255), Expect = 4e-22
Identities = 73/229 (31%), Positives = 113/229 (49%), Gaps = 17/229 (7%)
Query: 409 VKVLKGFSIHVKPGECVALVGSSGCGKSTVLQL----LQR---------LYDPQAGSVXX 455
+ L +I + G+ +VG GCGKS++L +Q+ L D + G
Sbjct: 693 IPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPS 752
Query: 456 XXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFI 515
R + Q+P L T+ +NI SP ++ + V E I
Sbjct: 753 PERETATDLDIRKRGPVAYASQKPWLLNATVEENIIFESP-FNKQRYKMVIEACSLQPDI 811
Query: 516 SLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPH-SERQVQAA 574
+LP+G T IGERG +LSGGQ+QRI++AR+L + V+ LD+ SALD H S+ +QA
Sbjct: 812 DILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLMQAG 871
Query: 575 LDR--ASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAK 621
+ RT + V+H+L + +AD II M G I +GT +D +++
Sbjct: 872 ILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSE 920
Score = 85.0 bits (201), Expect = 2e-15
Identities = 103/443 (23%), Positives = 194/443 (43%), Gaps = 37/443 (8%)
Query: 782 LYSVLFVVIAAVAGISMCL-QSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVG 840
+Y+++F V+ ++ GI +CL S T GLK+ RL ++ + FF ET +G
Sbjct: 1062 VYAMVFTVLCSL-GIVLCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFF--ETTPLG 1118
Query: 841 AICARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLMVGSI 900
+I R S D + + + + + + V L ISY + LVA LPL +
Sbjct: 1119 SILNRFSSDCNTIDQHIPSTLECLSRS-TLLCVSALAVISYVTPVFLVA--LLPLAIVCY 1175
Query: 901 WLEGIISQKA----QIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQK---FQDALK 953
+++ + Q+D+ + + A E V + T+++ E F QK + D+
Sbjct: 1176 FIQKYFRVASRDLQQLDDTTQLPLLSHFA-ETVEGLTTIRAFRYEARFQQKLLEYTDSNN 1234
Query: 954 TACVAVAYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVA---YGEMEYKLVLL-VNEAI 1009
A + + RW L V + ++ C + ++ + E+ LV L + A+
Sbjct: 1235 IASLFLTAANRW------LEVRMEYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTYAL 1288
Query: 1010 MYGAYMLGQSLVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKD--KKDWVASGNFSMR 1067
M Y L + + RI +++ + + + + K+W G ++
Sbjct: 1289 MVSNY-LNWMVRNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQ 1347
Query: 1068 DVEFCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDN 1127
++ Y + + VLK ++ + G+ I + G +G GKS+ F R D G I +D
Sbjct: 1348 NLSVRYDSS-LKPVLKHVNALISPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDG 1406
Query: 1128 RDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSF 1187
DI + L + LR +L ++ Q+PVL ++ N+ D RK + + A + A +
Sbjct: 1407 IDI-AKLPLHTLRSRLSIILQDPVLFSGTIRFNL---DPERKCSDSTLWEALEIAQLKLV 1462
Query: 1188 IVSLP----KAVTEALEKAAKGR 1206
+ +LP +TE E ++G+
Sbjct: 1463 VKALPGGLDAIITEGGENFSQGQ 1485
Score = 39.9 bits (89), Expect = 0.056
Identities = 27/91 (29%), Positives = 40/91 (43%), Gaps = 4/91 (4%)
Query: 1159 ENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAVTEALEK----AAKGRTCITIAHR 1214
EN + G V + S+ A L+K A RT +TIAHR
Sbjct: 1479 ENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHR 1538
Query: 1215 LSTVKDADLICVIDKGKIVERGTHAELVSMK 1245
+ T+ ADL+ V+ +G I+E +L+S K
Sbjct: 1539 VHTILSADLVIVLKRGAILEFDKPEKLLSRK 1569
>L78243-2|AAB02418.1| 1582|Homo sapiens SUR1 protein.
Length = 1582
Score = 144 bits (349), Expect = 2e-33
Identities = 122/521 (23%), Positives = 236/521 (45%), Gaps = 21/521 (4%)
Query: 107 AMAIGMFISIGVSLVFCVLSFSLISWSALRQITRIRTLFLRSVLRQDMSWYDTDSEFNLA 166
AM S+G+ V C+++ + W+ L+ R+ L ++ M +++T ++
Sbjct: 1065 AMVFTAVCSLGI--VLCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSIL 1122
Query: 167 SKMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPLGWQLTLACAAVMPFSVITSIAL 226
++ S + +I + + L +S ++++C+ + + + A++P +++
Sbjct: 1123 NRFSSDCNTIDQHIPSTLECLSR---STLLCVSALAVISYVTPVFLVALLPLAIVCYFIQ 1179
Query: 227 SNYQTKS-SIREMESYSLAGKQAE--EILKSVRTIVAFGGENKEVERYRRLLEPAEEFGR 283
++ S +++++ + + E ++ + TI AF E ++LLE +
Sbjct: 1180 KYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAF---RYEARFQQKLLEYTDS-NN 1235
Query: 284 KRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVYSILFSVYMA 343
LF N W L + IG V ++S R+ G V L M
Sbjct: 1236 IASLFLTAAN--RW-LEVRMEYIGACVVLIAAVTSI-SNSLHRELSAGLVGLGLTYALMV 1291
Query: 344 TQSITFCVPHLEGFXXXXXXXXSIFHLIEREPK-IDSLQQKGLTPRRVV--GDILLEDVE 400
+ + + V +L I L++ E + + L L P+ G I ++++
Sbjct: 1292 SNYLNWMVRNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLS 1351
Query: 401 FCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXX 460
Y S + VLK + + PG+ + + G +G GKS+ R+ D G +
Sbjct: 1352 VRYDSSLK-PVLKHVNALISPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDI 1410
Query: 461 XXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPN 520
LRS L ++ Q+PVLF GTI N+ + + + EIA + LP
Sbjct: 1411 AKLPLHTLRSRLSIILQDPVLFSGTIRFNLD-PERKCSDSTLWEALEIAQLKLVVKALPG 1469
Query: 521 GYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASV 580
G D +I E G + S GQ+Q +AR+ +R+ ++ ++DEAT+++D +E +Q + A
Sbjct: 1470 GLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFA 1529
Query: 581 GRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAK 621
RT +T++HR+ TI++AD +I + +G I+E E L+ K
Sbjct: 1530 DRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRK 1570
Score = 105 bits (253), Expect = 8e-22
Identities = 73/230 (31%), Positives = 113/230 (49%), Gaps = 18/230 (7%)
Query: 409 VKVLKGFSIHVKPGECVALVGSSGCGKSTVLQL----LQR----------LYDPQAGSVX 454
+ L +I + G+ +VG GCGKS++L +Q+ L D + G
Sbjct: 693 IPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSSLPDSEIGEDP 752
Query: 455 XXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDF 514
R + Q+P L T+ +NI SP ++ + V E
Sbjct: 753 SPERETATDLDIRKRGPVAYASQKPWLLNATVEENIIFESP-FNKQRYKMVIEACSLQPD 811
Query: 515 ISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPH-SERQVQA 573
I +LP+G T IGERG +LSGGQ+QRI++AR+L + V+ LD+ SALD H S+ +QA
Sbjct: 812 IDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLMQA 871
Query: 574 ALDR--ASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAK 621
+ RT + V+H+L + +AD II M G I +GT +D +++
Sbjct: 872 GILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSE 921
Score = 83.8 bits (198), Expect = 3e-15
Identities = 102/443 (23%), Positives = 193/443 (43%), Gaps = 37/443 (8%)
Query: 782 LYSVLFVVIAAVAGISMCL-QSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVG 840
+Y+++F + ++ GI +CL S T GLK+ RL ++ + FF ET +G
Sbjct: 1063 VYAMVFTAVCSL-GIVLCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFF--ETTPLG 1119
Query: 841 AICARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLMVGSI 900
+I R S D + + + + + + V L ISY + LVA LPL +
Sbjct: 1120 SILNRFSSDCNTIDQHIPSTLECLSRS-TLLCVSALAVISYVTPVFLVA--LLPLAIVCY 1176
Query: 901 WLEGIISQKA----QIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQK---FQDALK 953
+++ + Q+D+ + + A E V + T+++ E F QK + D+
Sbjct: 1177 FIQKYFRVASRDLQQLDDTTQLPLLSHFA-ETVEGLTTIRAFRYEARFQQKLLEYTDSNN 1235
Query: 954 TACVAVAYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVA---YGEMEYKLVLL-VNEAI 1009
A + + RW L V + ++ C + ++ + E+ LV L + A+
Sbjct: 1236 IASLFLTAANRW------LEVRMEYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTYAL 1289
Query: 1010 MYGAYMLGQSLVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKD--KKDWVASGNFSMR 1067
M Y L + + RI +++ + + + + K+W G ++
Sbjct: 1290 MVSNY-LNWMVRNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQ 1348
Query: 1068 DVEFCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDN 1127
++ Y + + VLK ++ + G+ I + G +G GKS+ F R D G I +D
Sbjct: 1349 NLSVRYDSS-LKPVLKHVNALISPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDG 1407
Query: 1128 RDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSF 1187
DI + L + LR +L ++ Q+PVL ++ N+ D RK + + A + A +
Sbjct: 1408 IDI-AKLPLHTLRSRLSIILQDPVLFSGTIRFNL---DPERKCSDSTLWEALEIAQLKLV 1463
Query: 1188 IVSLP----KAVTEALEKAAKGR 1206
+ +LP +TE E ++G+
Sbjct: 1464 VKALPGGLDAIITEGGENFSQGQ 1486
Score = 39.9 bits (89), Expect = 0.056
Identities = 27/91 (29%), Positives = 40/91 (43%), Gaps = 4/91 (4%)
Query: 1159 ENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAVTEALEK----AAKGRTCITIAHR 1214
EN + G V + S+ A L+K A RT +TIAHR
Sbjct: 1480 ENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHR 1539
Query: 1215 LSTVKDADLICVIDKGKIVERGTHAELVSMK 1245
+ T+ ADL+ V+ +G I+E +L+S K
Sbjct: 1540 VHTILSADLVIVLKRGAILEFDKPEKLLSRK 1570
>L78243-1|AAB02417.1| 1581|Homo sapiens SUR1 protein.
Length = 1581
Score = 144 bits (349), Expect = 2e-33
Identities = 122/521 (23%), Positives = 236/521 (45%), Gaps = 21/521 (4%)
Query: 107 AMAIGMFISIGVSLVFCVLSFSLISWSALRQITRIRTLFLRSVLRQDMSWYDTDSEFNLA 166
AM S+G+ V C+++ + W+ L+ R+ L ++ M +++T ++
Sbjct: 1064 AMVFTAVCSLGI--VLCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSIL 1121
Query: 167 SKMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPLGWQLTLACAAVMPFSVITSIAL 226
++ S + +I + + L +S ++++C+ + + + A++P +++
Sbjct: 1122 NRFSSDCNTIDQHIPSTLECLSR---STLLCVSALAVISYVTPVFLVALLPLAIVCYFIQ 1178
Query: 227 SNYQTKS-SIREMESYSLAGKQAE--EILKSVRTIVAFGGENKEVERYRRLLEPAEEFGR 283
++ S +++++ + + E ++ + TI AF E ++LLE +
Sbjct: 1179 KYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAF---RYEARFQQKLLEYTDS-NN 1234
Query: 284 KRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVYSILFSVYMA 343
LF N W L + IG V ++S R+ G V L M
Sbjct: 1235 IASLFLTAAN--RW-LEVRMEYIGACVVLIAAVTSI-SNSLHRELSAGLVGLGLTYALMV 1290
Query: 344 TQSITFCVPHLEGFXXXXXXXXSIFHLIEREPK-IDSLQQKGLTPRRVV--GDILLEDVE 400
+ + + V +L I L++ E + + L L P+ G I ++++
Sbjct: 1291 SNYLNWMVRNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLS 1350
Query: 401 FCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXX 460
Y S + VLK + + PG+ + + G +G GKS+ R+ D G +
Sbjct: 1351 VRYDSSLK-PVLKHVNALISPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDI 1409
Query: 461 XXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPN 520
LRS L ++ Q+PVLF GTI N+ + + + EIA + LP
Sbjct: 1410 AKLPLHTLRSRLSIILQDPVLFSGTIRFNLD-PERKCSDSTLWEALEIAQLKLVVKALPG 1468
Query: 521 GYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASV 580
G D +I E G + S GQ+Q +AR+ +R+ ++ ++DEAT+++D +E +Q + A
Sbjct: 1469 GLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFA 1528
Query: 581 GRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAK 621
RT +T++HR+ TI++AD +I + +G I+E E L+ K
Sbjct: 1529 DRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRK 1569
Score = 106 bits (255), Expect = 4e-22
Identities = 73/229 (31%), Positives = 113/229 (49%), Gaps = 17/229 (7%)
Query: 409 VKVLKGFSIHVKPGECVALVGSSGCGKSTVLQL----LQR---------LYDPQAGSVXX 455
+ L +I + G+ +VG GCGKS++L +Q+ L D + G
Sbjct: 693 IPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPS 752
Query: 456 XXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFI 515
R + Q+P L T+ +NI SP ++ + V E I
Sbjct: 753 PERETATDLDIRKRGPVAYASQKPWLLNATVEENIIFESP-FNKQRYKMVIEACSLQPDI 811
Query: 516 SLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPH-SERQVQAA 574
+LP+G T IGERG +LSGGQ+QRI++AR+L + V+ LD+ SALD H S+ +QA
Sbjct: 812 DILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLMQAG 871
Query: 575 LDR--ASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAK 621
+ RT + V+H+L + +AD II M G I +GT +D +++
Sbjct: 872 ILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSE 920
Score = 83.8 bits (198), Expect = 3e-15
Identities = 102/443 (23%), Positives = 193/443 (43%), Gaps = 37/443 (8%)
Query: 782 LYSVLFVVIAAVAGISMCL-QSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVG 840
+Y+++F + ++ GI +CL S T GLK+ RL ++ + FF ET +G
Sbjct: 1062 VYAMVFTAVCSL-GIVLCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFF--ETTPLG 1118
Query: 841 AICARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLMVGSI 900
+I R S D + + + + + + V L ISY + LVA LPL +
Sbjct: 1119 SILNRFSSDCNTIDQHIPSTLECLSRS-TLLCVSALAVISYVTPVFLVA--LLPLAIVCY 1175
Query: 901 WLEGIISQKA----QIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQK---FQDALK 953
+++ + Q+D+ + + A E V + T+++ E F QK + D+
Sbjct: 1176 FIQKYFRVASRDLQQLDDTTQLPLLSHFA-ETVEGLTTIRAFRYEARFQQKLLEYTDSNN 1234
Query: 954 TACVAVAYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVA---YGEMEYKLVLL-VNEAI 1009
A + + RW L V + ++ C + ++ + E+ LV L + A+
Sbjct: 1235 IASLFLTAANRW------LEVRMEYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTYAL 1288
Query: 1010 MYGAYMLGQSLVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKD--KKDWVASGNFSMR 1067
M Y L + + RI +++ + + + + K+W G ++
Sbjct: 1289 MVSNY-LNWMVRNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQ 1347
Query: 1068 DVEFCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDN 1127
++ Y + + VLK ++ + G+ I + G +G GKS+ F R D G I +D
Sbjct: 1348 NLSVRYDSS-LKPVLKHVNALISPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDG 1406
Query: 1128 RDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSF 1187
DI + L + LR +L ++ Q+PVL ++ N+ D RK + + A + A +
Sbjct: 1407 IDI-AKLPLHTLRSRLSIILQDPVLFSGTIRFNL---DPERKCSDSTLWEALEIAQLKLV 1462
Query: 1188 IVSLP----KAVTEALEKAAKGR 1206
+ +LP +TE E ++G+
Sbjct: 1463 VKALPGGLDAIITEGGENFSQGQ 1485
Score = 39.9 bits (89), Expect = 0.056
Identities = 27/91 (29%), Positives = 40/91 (43%), Gaps = 4/91 (4%)
Query: 1159 ENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAVTEALEK----AAKGRTCITIAHR 1214
EN + G V + S+ A L+K A RT +TIAHR
Sbjct: 1479 ENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHR 1538
Query: 1215 LSTVKDADLICVIDKGKIVERGTHAELVSMK 1245
+ T+ ADL+ V+ +G I+E +L+S K
Sbjct: 1539 VHTILSADLVIVLKRGAILEFDKPEKLLSRK 1569
>L78207-1|AAB02278.1| 1581|Homo sapiens sulfonylurea receptor protein.
Length = 1581
Score = 144 bits (349), Expect = 2e-33
Identities = 122/521 (23%), Positives = 236/521 (45%), Gaps = 21/521 (4%)
Query: 107 AMAIGMFISIGVSLVFCVLSFSLISWSALRQITRIRTLFLRSVLRQDMSWYDTDSEFNLA 166
AM S+G+ V C+++ + W+ L+ R+ L ++ M +++T ++
Sbjct: 1064 AMVFTAVCSLGI--VLCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSIL 1121
Query: 167 SKMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPLGWQLTLACAAVMPFSVITSIAL 226
++ S + +I + + L +S ++++C+ + + + A++P +++
Sbjct: 1122 NRFSSDCNTIDQHIPSTLECLSR---STLLCVSALAVISYVTPVFLVALLPLAIVCYFIQ 1178
Query: 227 SNYQTKS-SIREMESYSLAGKQAE--EILKSVRTIVAFGGENKEVERYRRLLEPAEEFGR 283
++ S +++++ + + E ++ + TI AF E ++LLE +
Sbjct: 1179 KYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAF---RYEARFQQKLLEYTDS-NN 1234
Query: 284 KRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVYSILFSVYMA 343
LF N W L + IG V ++S R+ G V L M
Sbjct: 1235 IASLFLTAAN--RW-LEVRMEYIGACVVLIAAVTSI-SNSLHRELSAGLVGLGLTYALMV 1290
Query: 344 TQSITFCVPHLEGFXXXXXXXXSIFHLIEREPK-IDSLQQKGLTPRRVV--GDILLEDVE 400
+ + + V +L I L++ E + + L L P+ G I ++++
Sbjct: 1291 SNYLNWMVRNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLS 1350
Query: 401 FCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXX 460
Y S + VLK + + PG+ + + G +G GKS+ R+ D G +
Sbjct: 1351 VRYDSSLK-PVLKHVNALISPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDI 1409
Query: 461 XXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPN 520
LRS L ++ Q+PVLF GTI N+ + + + EIA + LP
Sbjct: 1410 AKLPLHTLRSRLSIILQDPVLFSGTIRFNLD-PERKCSDSTLWEALEIAQLKLVVKALPG 1468
Query: 521 GYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASV 580
G D +I E G + S GQ+Q +AR+ +R+ ++ ++DEAT+++D +E +Q + A
Sbjct: 1469 GLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFA 1528
Query: 581 GRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAK 621
RT +T++HR+ TI++AD +I + +G I+E E L+ K
Sbjct: 1529 DRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRK 1569
Score = 106 bits (255), Expect = 4e-22
Identities = 73/229 (31%), Positives = 113/229 (49%), Gaps = 17/229 (7%)
Query: 409 VKVLKGFSIHVKPGECVALVGSSGCGKSTVLQL----LQR---------LYDPQAGSVXX 455
+ L +I + G+ +VG GCGKS++L +Q+ L D + G
Sbjct: 693 IPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPS 752
Query: 456 XXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFI 515
R + Q+P L T+ +NI SP ++ + V E I
Sbjct: 753 PERETATDLDIRKRGPVAYASQKPWLLNATVEENIIFESP-FNKQRYKMVIEACSLQPDI 811
Query: 516 SLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPH-SERQVQAA 574
+LP+G T IGERG +LSGGQ+QRI++AR+L + V+ LD+ SALD H S+ +QA
Sbjct: 812 DILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLMQAG 871
Query: 575 LDR--ASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAK 621
+ RT + V+H+L + +AD II M G I +GT +D +++
Sbjct: 872 ILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSE 920
Score = 83.8 bits (198), Expect = 3e-15
Identities = 102/443 (23%), Positives = 193/443 (43%), Gaps = 37/443 (8%)
Query: 782 LYSVLFVVIAAVAGISMCL-QSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVG 840
+Y+++F + ++ GI +CL S T GLK+ RL ++ + FF ET +G
Sbjct: 1062 VYAMVFTAVCSL-GIVLCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFF--ETTPLG 1118
Query: 841 AICARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLMVGSI 900
+I R S D + + + + + + V L ISY + LVA LPL +
Sbjct: 1119 SILNRFSSDCNTIDQHIPSTLECLSRS-TLLCVSALAVISYVTPVFLVA--LLPLAIVCY 1175
Query: 901 WLEGIISQKA----QIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQK---FQDALK 953
+++ + Q+D+ + + A E V + T+++ E F QK + D+
Sbjct: 1176 FIQKYFRVASRDLQQLDDTTQLPLLSHFA-ETVEGLTTIRAFRYEARFQQKLLEYTDSNN 1234
Query: 954 TACVAVAYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVA---YGEMEYKLVLL-VNEAI 1009
A + + RW L V + ++ C + ++ + E+ LV L + A+
Sbjct: 1235 IASLFLTAANRW------LEVRMEYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTYAL 1288
Query: 1010 MYGAYMLGQSLVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKD--KKDWVASGNFSMR 1067
M Y L + + RI +++ + + + + K+W G ++
Sbjct: 1289 MVSNY-LNWMVRNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQ 1347
Query: 1068 DVEFCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDN 1127
++ Y + + VLK ++ + G+ I + G +G GKS+ F R D G I +D
Sbjct: 1348 NLSVRYDSS-LKPVLKHVNALISPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDG 1406
Query: 1128 RDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSF 1187
DI + L + LR +L ++ Q+PVL ++ N+ D RK + + A + A +
Sbjct: 1407 IDI-AKLPLHTLRSRLSIILQDPVLFSGTIRFNL---DPERKCSDSTLWEALEIAQLKLV 1462
Query: 1188 IVSLP----KAVTEALEKAAKGR 1206
+ +LP +TE E ++G+
Sbjct: 1463 VKALPGGLDAIITEGGENFSQGQ 1485
Score = 39.9 bits (89), Expect = 0.056
Identities = 27/91 (29%), Positives = 40/91 (43%), Gaps = 4/91 (4%)
Query: 1159 ENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAVTEALEK----AAKGRTCITIAHR 1214
EN + G V + S+ A L+K A RT +TIAHR
Sbjct: 1479 ENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHR 1538
Query: 1215 LSTVKDADLICVIDKGKIVERGTHAELVSMK 1245
+ T+ ADL+ V+ +G I+E +L+S K
Sbjct: 1539 VHTILSADLVIVLKRGAILEFDKPEKLLSRK 1569
>Y17151-1|CAA76658.2| 1527|Homo sapiens multidrug resistance protein 3
(ABCC3) protein.
Length = 1527
Score = 144 bits (348), Expect = 2e-33
Identities = 125/527 (23%), Positives = 241/527 (45%), Gaps = 25/527 (4%)
Query: 107 AMAIGMFISIGVSLVFCVLSFSLISWSALRQITRI-RTLFLRSVLRQDMSWYDTDSEFNL 165
++ +G++ ++G+ F V+ ++ + Q R+ L + +R S++DT +
Sbjct: 1009 SLRLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRI 1068
Query: 166 ASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPLGWQLTLACAAVMPFSVITSIA 225
+ S+++ + E + + ++ N ++ L L ++P +V+ ++
Sbjct: 1069 LNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMA---STPLFTVVILPLAVLYTLV 1125
Query: 226 LSNYQ-TKSSIREMESYSLAG--KQAEEILKSVRTIVAFGGENKEVERYRRLLEPAEEFG 282
Y T ++ +ES S + E + I A+ +++ E ++ +
Sbjct: 1126 QRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYN-RSRDFE----IISDTKVDA 1180
Query: 283 RKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVYSILFSVYM 342
+R + + + W L+ + +G + S+L VG S V
Sbjct: 1181 NQRSCYPYIISN-RW-LSIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTF 1238
Query: 343 ATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKI--DSLQQKGLTPRRVVGDILLEDVE 400
A + + LE P + S +G PR G++ +
Sbjct: 1239 ALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPR---GEVEFRNYS 1295
Query: 401 FCYPSRPEVK-VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXX 459
Y RP + VL+ S+HV GE V +VG +G GKS++ L R+ + G +
Sbjct: 1296 VRY--RPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLN 1353
Query: 460 XXXXXXSWLRSSLGVVGQEPVLFRGTIYDNI-AIGSPEATREEIQRVAEIAYAHDFISLL 518
LRS L ++ Q+P+LF GT+ N+ GS + E+I E+++ H F+S
Sbjct: 1354 VADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGS--YSEEDIWWALELSHLHTFVSSQ 1411
Query: 519 PNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRA 578
P G D E G +LS GQ+Q + +AR+LLR+ +L+LDEAT+A+D ++ +QA +
Sbjct: 1412 PAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQ 1471
Query: 579 SVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYH 625
T +T++HRL+TI++ R++ +D+GV+ E + +L+ A+G ++
Sbjct: 1472 FDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIFY 1518
Score = 97.1 bits (231), Expect = 4e-19
Identities = 69/260 (26%), Positives = 121/260 (46%), Gaps = 21/260 (8%)
Query: 412 LKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSS 471
L I V G VA+VG GCGKS+++ L + G V ++ S
Sbjct: 644 LHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVH-------------MKGS 690
Query: 472 LGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGA 531
+ V Q+ + T+ +N+ G + Q + A D + +LP G T IGE+G
Sbjct: 691 VAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLAD-LEMLPGGDQTEIGEKGI 749
Query: 532 SLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV---QAALDRASVGRTTITVS 588
+LSGGQ+QR+++AR++ + + LLD+ SA+D H + + + G+T + V+
Sbjct: 750 NLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVT 809
Query: 589 HRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENKEPADIEPLIEEAD 648
H +S + D II + G + E G + L++ G + + +++ +E +
Sbjct: 810 HGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTALE 869
Query: 649 GDGDN----IEPTVPSRLDV 664
G D IE T+ + D+
Sbjct: 870 GAEDKEALLIEDTLSNHTDL 889
Score = 57.6 bits (133), Expect = 3e-07
Identities = 81/417 (19%), Positives = 161/417 (38%), Gaps = 28/417 (6%)
Query: 786 LFVVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICAR 845
++ + + G + L + + G++ L + ++ FFD T G I
Sbjct: 1014 VYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFD--TTPSGRILNC 1071
Query: 846 LSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLMVGSIWLEGI 905
S D V I ++L + + ++ ++ L V LPL V ++
Sbjct: 1072 FSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMA---STPLFTVVILPLAVLYTLVQRF 1128
Query: 906 ISQKAQIDERNAMESATAIAT---EAVVSIKTVQSLGVETVF---LQKFQDALKTACVAV 959
+ ++ +R S + I + E V +++ F DA + +C
Sbjct: 1129 YAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPY 1188
Query: 960 AYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEYK--LVLLVNEAIMYGAYMLG 1017
RW L + + F+ C ++ A+ G LV L + + L
Sbjct: 1189 IISNRW------LSIGVEFVGNC-VVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALN 1241
Query: 1018 QSLVYAPSLNTAKACGARILSIIQRQPKIHNAV-GVKDKKDWVASGNFSMRDVEFCYPTR 1076
+ L + R+ + + + V G + + W G R+ Y R
Sbjct: 1242 WMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRY--R 1299
Query: 1077 PS-QRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALT 1135
P VL+ + L + G+ + +VG +G GKS++ R + G I +D ++ + +
Sbjct: 1300 PGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNV-ADIG 1358
Query: 1136 IPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP 1192
+ LR QL ++ Q+P+L +L N+ D + +I A + +++H+F+ S P
Sbjct: 1359 LHDLRSQLTIIPQDPILFSGTLRMNL---DPFGSYSEEDIWWALELSHLHTFVSSQP 1412
>AF104943-1|AAD04170.1| 1527|Homo sapiens ABC transporter MOAT-D
protein.
Length = 1527
Score = 144 bits (348), Expect = 2e-33
Identities = 125/527 (23%), Positives = 241/527 (45%), Gaps = 25/527 (4%)
Query: 107 AMAIGMFISIGVSLVFCVLSFSLISWSALRQITRI-RTLFLRSVLRQDMSWYDTDSEFNL 165
++ +G++ ++G+ F V+ ++ + Q R+ L + +R S++DT +
Sbjct: 1009 SLRLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRI 1068
Query: 166 ASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPLGWQLTLACAAVMPFSVITSIA 225
+ S+++ + E + + ++ N ++ L L ++P +V+ ++
Sbjct: 1069 LNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMA---STPLFTVVILPLAVLYTLV 1125
Query: 226 LSNYQ-TKSSIREMESYSLAG--KQAEEILKSVRTIVAFGGENKEVERYRRLLEPAEEFG 282
Y T ++ +ES S + E + I A+ +++ E ++ +
Sbjct: 1126 QRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYN-RSRDFE----IISDTKVDA 1180
Query: 283 RKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVYSILFSVYM 342
+R + + + W L+ + +G + S+L VG S V
Sbjct: 1181 NQRSCYPYIISN-RW-LSIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTF 1238
Query: 343 ATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKI--DSLQQKGLTPRRVVGDILLEDVE 400
A + + LE P + S +G PR G++ +
Sbjct: 1239 ALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPR---GEVEFRNYS 1295
Query: 401 FCYPSRPEVK-VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXX 459
Y RP + VL+ S+HV GE V +VG +G GKS++ L R+ + G +
Sbjct: 1296 VRY--RPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLN 1353
Query: 460 XXXXXXSWLRSSLGVVGQEPVLFRGTIYDNI-AIGSPEATREEIQRVAEIAYAHDFISLL 518
LRS L ++ Q+P+LF GT+ N+ GS + E+I E+++ H F+S
Sbjct: 1354 VADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGS--YSEEDIWWALELSHLHTFVSSQ 1411
Query: 519 PNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRA 578
P G D E G +LS GQ+Q + +AR+LLR+ +L+LDEAT+A+D ++ +QA +
Sbjct: 1412 PAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQ 1471
Query: 579 SVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYH 625
T +T++HRL+TI++ R++ +D+GV+ E + +L+ A+G ++
Sbjct: 1472 FDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIFY 1518
Score = 97.1 bits (231), Expect = 4e-19
Identities = 69/260 (26%), Positives = 121/260 (46%), Gaps = 21/260 (8%)
Query: 412 LKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSS 471
L I V G VA+VG GCGKS+++ L + G V ++ S
Sbjct: 644 LHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVH-------------MKGS 690
Query: 472 LGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGA 531
+ V Q+ + T+ +N+ G + Q + A D + +LP G T IGE+G
Sbjct: 691 VAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLAD-LEMLPGGDQTEIGEKGI 749
Query: 532 SLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV---QAALDRASVGRTTITVS 588
+LSGGQ+QR+++AR++ + + LLD+ SA+D H + + + G+T + V+
Sbjct: 750 NLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVT 809
Query: 589 HRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENKEPADIEPLIEEAD 648
H +S + D II + G + E G + L++ G + + +++ +E +
Sbjct: 810 HGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTALE 869
Query: 649 GDGDN----IEPTVPSRLDV 664
G D IE T+ + D+
Sbjct: 870 GAEDKEALLIEDTLSNHTDL 889
Score = 57.6 bits (133), Expect = 3e-07
Identities = 81/417 (19%), Positives = 161/417 (38%), Gaps = 28/417 (6%)
Query: 786 LFVVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICAR 845
++ + + G + L + + G++ L + ++ FFD T G I
Sbjct: 1014 VYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFD--TTPSGRILNC 1071
Query: 846 LSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLMVGSIWLEGI 905
S D V I ++L + + ++ ++ L V LPL V ++
Sbjct: 1072 FSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMA---STPLFTVVILPLAVLYTLVQRF 1128
Query: 906 ISQKAQIDERNAMESATAIAT---EAVVSIKTVQSLGVETVF---LQKFQDALKTACVAV 959
+ ++ +R S + I + E V +++ F DA + +C
Sbjct: 1129 YAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPY 1188
Query: 960 AYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEYK--LVLLVNEAIMYGAYMLG 1017
RW L + + F+ C ++ A+ G LV L + + L
Sbjct: 1189 IISNRW------LSIGVEFVGNC-VVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALN 1241
Query: 1018 QSLVYAPSLNTAKACGARILSIIQRQPKIHNAV-GVKDKKDWVASGNFSMRDVEFCYPTR 1076
+ L + R+ + + + V G + + W G R+ Y R
Sbjct: 1242 WMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRY--R 1299
Query: 1077 PS-QRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALT 1135
P VL+ + L + G+ + +VG +G GKS++ R + G I +D ++ + +
Sbjct: 1300 PGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNV-ADIG 1358
Query: 1136 IPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP 1192
+ LR QL ++ Q+P+L +L N+ D + +I A + +++H+F+ S P
Sbjct: 1359 LHDLRSQLTIIPQDPILFSGTLRMNL---DPFGSYSEEDIWWALELSHLHTFVSSQP 1412
>AF085690-1|AAD02845.1| 1527|Homo sapiens multidrug
resistance-associated protein 3 protein.
Length = 1527
Score = 144 bits (348), Expect = 2e-33
Identities = 125/527 (23%), Positives = 241/527 (45%), Gaps = 25/527 (4%)
Query: 107 AMAIGMFISIGVSLVFCVLSFSLISWSALRQITRI-RTLFLRSVLRQDMSWYDTDSEFNL 165
++ +G++ ++G+ F V+ ++ + Q R+ L + +R S++DT +
Sbjct: 1009 SLRLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRI 1068
Query: 166 ASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPLGWQLTLACAAVMPFSVITSIA 225
+ S+++ + E + + ++ N ++ L L ++P +V+ ++
Sbjct: 1069 LNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMA---STPLFTVVILPLAVLYTLV 1125
Query: 226 LSNYQ-TKSSIREMESYSLAG--KQAEEILKSVRTIVAFGGENKEVERYRRLLEPAEEFG 282
Y T ++ +ES S + E + I A+ +++ E ++ +
Sbjct: 1126 QRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYN-RSRDFE----IISDTKVDA 1180
Query: 283 RKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVYSILFSVYM 342
+R + + + W L+ + +G + S+L VG S V
Sbjct: 1181 NQRSCYPYIISN-RW-LSIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTF 1238
Query: 343 ATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKI--DSLQQKGLTPRRVVGDILLEDVE 400
A + + LE P + S +G PR G++ +
Sbjct: 1239 ALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPR---GEVEFRNYS 1295
Query: 401 FCYPSRPEVK-VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXX 459
Y RP + VL+ S+HV GE V +VG +G GKS++ L R+ + G +
Sbjct: 1296 VRY--RPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLN 1353
Query: 460 XXXXXXSWLRSSLGVVGQEPVLFRGTIYDNI-AIGSPEATREEIQRVAEIAYAHDFISLL 518
LRS L ++ Q+P+LF GT+ N+ GS + E+I E+++ H F+S
Sbjct: 1354 VADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGS--YSEEDIWWALELSHLHTFVSSQ 1411
Query: 519 PNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRA 578
P G D E G +LS GQ+Q + +AR+LLR+ +L+LDEAT+A+D ++ +QA +
Sbjct: 1412 PAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQ 1471
Query: 579 SVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYH 625
T +T++HRL+TI++ R++ +D+GV+ E + +L+ A+G ++
Sbjct: 1472 FDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIFY 1518
Score = 97.1 bits (231), Expect = 4e-19
Identities = 69/260 (26%), Positives = 121/260 (46%), Gaps = 21/260 (8%)
Query: 412 LKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSS 471
L I V G VA+VG GCGKS+++ L + G V ++ S
Sbjct: 644 LHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVH-------------MKGS 690
Query: 472 LGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGA 531
+ V Q+ + T+ +N+ G + Q + A D + +LP G T IGE+G
Sbjct: 691 VAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLAD-LEMLPGGDQTEIGEKGI 749
Query: 532 SLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV---QAALDRASVGRTTITVS 588
+LSGGQ+QR+++AR++ + + LLD+ SA+D H + + + G+T + V+
Sbjct: 750 NLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVT 809
Query: 589 HRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENKEPADIEPLIEEAD 648
H +S + D II + G + E G + L++ G + + +++ +E +
Sbjct: 810 HGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTALE 869
Query: 649 GDGDN----IEPTVPSRLDV 664
G D IE T+ + D+
Sbjct: 870 GAEDKEALLIEDTLSNHTDL 889
Score = 57.6 bits (133), Expect = 3e-07
Identities = 81/417 (19%), Positives = 161/417 (38%), Gaps = 28/417 (6%)
Query: 786 LFVVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICAR 845
++ + + G + L + + G++ L + ++ FFD T G I
Sbjct: 1014 VYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFD--TTPSGRILNC 1071
Query: 846 LSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLMVGSIWLEGI 905
S D V I ++L + + ++ ++ L V LPL V ++
Sbjct: 1072 FSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMA---STPLFTVVILPLAVLYTLVQRF 1128
Query: 906 ISQKAQIDERNAMESATAIAT---EAVVSIKTVQSLGVETVF---LQKFQDALKTACVAV 959
+ ++ +R S + I + E V +++ F DA + +C
Sbjct: 1129 YAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPY 1188
Query: 960 AYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEYK--LVLLVNEAIMYGAYMLG 1017
RW L + + F+ C ++ A+ G LV L + + L
Sbjct: 1189 IISNRW------LSIGVEFVGNC-VVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALN 1241
Query: 1018 QSLVYAPSLNTAKACGARILSIIQRQPKIHNAV-GVKDKKDWVASGNFSMRDVEFCYPTR 1076
+ L + R+ + + + V G + + W G R+ Y R
Sbjct: 1242 WMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRY--R 1299
Query: 1077 PS-QRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALT 1135
P VL+ + L + G+ + +VG +G GKS++ R + G I +D ++ + +
Sbjct: 1300 PGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNV-ADIG 1358
Query: 1136 IPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP 1192
+ LR QL ++ Q+P+L +L N+ D + +I A + +++H+F+ S P
Sbjct: 1359 LHDLRSQLTIIPQDPILFSGTLRMNL---DPFGSYSEEDIWWALELSHLHTFVSSQP 1412
>AF009670-1|AAD01430.1| 1528|Homo sapiens MRP3 protein.
Length = 1528
Score = 144 bits (348), Expect = 2e-33
Identities = 125/527 (23%), Positives = 241/527 (45%), Gaps = 25/527 (4%)
Query: 107 AMAIGMFISIGVSLVFCVLSFSLISWSALRQITRI-RTLFLRSVLRQDMSWYDTDSEFNL 165
++ +G++ ++G+ F V+ ++ + Q R+ L + +R S++DT +
Sbjct: 1010 SLRLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRI 1069
Query: 166 ASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPLGWQLTLACAAVMPFSVITSIA 225
+ S+++ + E + + ++ N ++ L L ++P +V+ ++
Sbjct: 1070 LNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMA---STPLFTVVILPLAVLYTLV 1126
Query: 226 LSNYQ-TKSSIREMESYSLAG--KQAEEILKSVRTIVAFGGENKEVERYRRLLEPAEEFG 282
Y T ++ +ES S + E + I A+ +++ E ++ +
Sbjct: 1127 QRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYN-RSRDFE----IISDTKVDA 1181
Query: 283 RKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVYSILFSVYM 342
+R + + + W L+ + +G + S+L VG S V
Sbjct: 1182 NQRSCYPYIISN-RW-LSIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTF 1239
Query: 343 ATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKI--DSLQQKGLTPRRVVGDILLEDVE 400
A + + LE P + S +G PR G++ +
Sbjct: 1240 ALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPR---GEVEFRNYS 1296
Query: 401 FCYPSRPEVK-VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXX 459
Y RP + VL+ S+HV GE V +VG +G GKS++ L R+ + G +
Sbjct: 1297 VRY--RPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLN 1354
Query: 460 XXXXXXSWLRSSLGVVGQEPVLFRGTIYDNI-AIGSPEATREEIQRVAEIAYAHDFISLL 518
LRS L ++ Q+P+LF GT+ N+ GS + E+I E+++ H F+S
Sbjct: 1355 VADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGS--YSEEDIWWALELSHLHTFVSSQ 1412
Query: 519 PNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRA 578
P G D E G +LS GQ+Q + +AR+LLR+ +L+LDEAT+A+D ++ +QA +
Sbjct: 1413 PAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQ 1472
Query: 579 SVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYH 625
T +T++HRL+TI++ R++ +D+GV+ E + +L+ A+G ++
Sbjct: 1473 FDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIFY 1519
Score = 97.1 bits (231), Expect = 4e-19
Identities = 69/260 (26%), Positives = 121/260 (46%), Gaps = 21/260 (8%)
Query: 412 LKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSS 471
L I V G VA+VG GCGKS+++ L + G V ++ S
Sbjct: 645 LHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVH-------------MKGS 691
Query: 472 LGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGA 531
+ V Q+ + T+ +N+ G + Q + A D + +LP G T IGE+G
Sbjct: 692 VAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLAD-LEMLPGGDQTEIGEKGI 750
Query: 532 SLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV---QAALDRASVGRTTITVS 588
+LSGGQ+QR+++AR++ + + LLD+ SA+D H + + + G+T + V+
Sbjct: 751 NLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVT 810
Query: 589 HRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENKEPADIEPLIEEAD 648
H +S + D II + G + E G + L++ G + + +++ +E +
Sbjct: 811 HGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTALE 870
Query: 649 GDGDN----IEPTVPSRLDV 664
G D IE T+ + D+
Sbjct: 871 GAEDKEALLIEDTLSNHTDL 890
Score = 57.6 bits (133), Expect = 3e-07
Identities = 81/417 (19%), Positives = 161/417 (38%), Gaps = 28/417 (6%)
Query: 786 LFVVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICAR 845
++ + + G + L + + G++ L + ++ FFD T G I
Sbjct: 1015 VYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFD--TTPSGRILNC 1072
Query: 846 LSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLMVGSIWLEGI 905
S D V I ++L + + ++ ++ L V LPL V ++
Sbjct: 1073 FSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMA---STPLFTVVILPLAVLYTLVQRF 1129
Query: 906 ISQKAQIDERNAMESATAIAT---EAVVSIKTVQSLGVETVF---LQKFQDALKTACVAV 959
+ ++ +R S + I + E V +++ F DA + +C
Sbjct: 1130 YAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPY 1189
Query: 960 AYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEYK--LVLLVNEAIMYGAYMLG 1017
RW L + + F+ C ++ A+ G LV L + + L
Sbjct: 1190 IISNRW------LSIGVEFVGNC-VVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALN 1242
Query: 1018 QSLVYAPSLNTAKACGARILSIIQRQPKIHNAV-GVKDKKDWVASGNFSMRDVEFCYPTR 1076
+ L + R+ + + + V G + + W G R+ Y R
Sbjct: 1243 WMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRY--R 1300
Query: 1077 PS-QRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALT 1135
P VL+ + L + G+ + +VG +G GKS++ R + G I +D ++ + +
Sbjct: 1301 PGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNV-ADIG 1359
Query: 1136 IPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP 1192
+ LR QL ++ Q+P+L +L N+ D + +I A + +++H+F+ S P
Sbjct: 1360 LHDLRSQLTIIPQDPILFSGTLRMNL---DPFGSYSEEDIWWALELSHLHTFVSSQP 1413
>AB010887-1|BAA28146.1| 1527|Homo sapiens multidrug
resistance-associated protein(MRP)-like protein-2 (MLP-2)
protein.
Length = 1527
Score = 144 bits (348), Expect = 2e-33
Identities = 125/527 (23%), Positives = 241/527 (45%), Gaps = 25/527 (4%)
Query: 107 AMAIGMFISIGVSLVFCVLSFSLISWSALRQITRI-RTLFLRSVLRQDMSWYDTDSEFNL 165
++ +G++ ++G+ F V+ ++ + Q R+ L + +R S++DT +
Sbjct: 1009 SLRLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRI 1068
Query: 166 ASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPLGWQLTLACAAVMPFSVITSIA 225
+ S+++ + E + + ++ N ++ L L ++P +V+ ++
Sbjct: 1069 LNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMA---STPLFTVVILPLAVLYTLV 1125
Query: 226 LSNYQ-TKSSIREMESYSLAG--KQAEEILKSVRTIVAFGGENKEVERYRRLLEPAEEFG 282
Y T ++ +ES S + E + I A+ +++ E ++ +
Sbjct: 1126 QRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYN-RSRDFE----IISDTKVDA 1180
Query: 283 RKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVYSILFSVYM 342
+R + + + W L+ + +G + S+L VG S V
Sbjct: 1181 NQRSCYPYIISN-RW-LSIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTF 1238
Query: 343 ATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKI--DSLQQKGLTPRRVVGDILLEDVE 400
A + + LE P + S +G PR G++ +
Sbjct: 1239 ALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPR---GEVEFRNYS 1295
Query: 401 FCYPSRPEVK-VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXX 459
Y RP + VL+ S+HV GE V +VG +G GKS++ L R+ + G +
Sbjct: 1296 VRY--RPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLN 1353
Query: 460 XXXXXXSWLRSSLGVVGQEPVLFRGTIYDNI-AIGSPEATREEIQRVAEIAYAHDFISLL 518
LRS L ++ Q+P+LF GT+ N+ GS + E+I E+++ H F+S
Sbjct: 1354 VADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGS--YSEEDIWWALELSHLHTFVSSQ 1411
Query: 519 PNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRA 578
P G D E G +LS GQ+Q + +AR+LLR+ +L+LDEAT+A+D ++ +QA +
Sbjct: 1412 PAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQ 1471
Query: 579 SVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYH 625
T +T++HRL+TI++ R++ +D+GV+ E + +L+ A+G ++
Sbjct: 1472 FDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIFY 1518
Score = 97.1 bits (231), Expect = 4e-19
Identities = 69/260 (26%), Positives = 121/260 (46%), Gaps = 21/260 (8%)
Query: 412 LKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSS 471
L I V G VA+VG GCGKS+++ L + G V ++ S
Sbjct: 644 LHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVH-------------MKGS 690
Query: 472 LGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGA 531
+ V Q+ + T+ +N+ G + Q + A D + +LP G T IGE+G
Sbjct: 691 VAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLAD-LEMLPGGDQTEIGEKGI 749
Query: 532 SLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV---QAALDRASVGRTTITVS 588
+LSGGQ+QR+++AR++ + + LLD+ SA+D H + + + G+T + V+
Sbjct: 750 NLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVT 809
Query: 589 HRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENKEPADIEPLIEEAD 648
H +S + D II + G + E G + L++ G + + +++ +E +
Sbjct: 810 HGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTALE 869
Query: 649 GDGDN----IEPTVPSRLDV 664
G D IE T+ + D+
Sbjct: 870 GAEDKEALLIEDTLSNHTDL 889
Score = 57.6 bits (133), Expect = 3e-07
Identities = 81/417 (19%), Positives = 161/417 (38%), Gaps = 28/417 (6%)
Query: 786 LFVVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICAR 845
++ + + G + L + + G++ L + ++ FFD T G I
Sbjct: 1014 VYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFD--TTPSGRILNC 1071
Query: 846 LSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLMVGSIWLEGI 905
S D V I ++L + + ++ ++ L V LPL V ++
Sbjct: 1072 FSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMA---STPLFTVVILPLAVLYTLVQRF 1128
Query: 906 ISQKAQIDERNAMESATAIAT---EAVVSIKTVQSLGVETVF---LQKFQDALKTACVAV 959
+ ++ +R S + I + E V +++ F DA + +C
Sbjct: 1129 YAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPY 1188
Query: 960 AYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEYK--LVLLVNEAIMYGAYMLG 1017
RW L + + F+ C ++ A+ G LV L + + L
Sbjct: 1189 IISNRW------LSIGVEFVGNC-VVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALN 1241
Query: 1018 QSLVYAPSLNTAKACGARILSIIQRQPKIHNAV-GVKDKKDWVASGNFSMRDVEFCYPTR 1076
+ L + R+ + + + V G + + W G R+ Y R
Sbjct: 1242 WMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRY--R 1299
Query: 1077 PS-QRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALT 1135
P VL+ + L + G+ + +VG +G GKS++ R + G I +D ++ + +
Sbjct: 1300 PGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNV-ADIG 1358
Query: 1136 IPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP 1192
+ LR QL ++ Q+P+L +L N+ D + +I A + +++H+F+ S P
Sbjct: 1359 LHDLRSQLTIIPQDPILFSGTLRMNL---DPFGSYSEEDIWWALELSHLHTFVSSQP 1412
>AF154001-1|AAD38185.1| 285|Homo sapiens MRP3s1 protein protein.
Length = 285
Score = 143 bits (346), Expect = 4e-33
Identities = 76/216 (35%), Positives = 128/216 (59%), Gaps = 3/216 (1%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
VL+ S+HV GE V +VG +G GKS++ L R+ + G + LRS
Sbjct: 63 VLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRS 122
Query: 471 SLGVVGQEPVLFRGTIYDNI-AIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGER 529
L ++ Q+P+LF GT+ N+ GS + E+I E+++ H F+S P G D E
Sbjct: 123 QLTIIPQDPILFSGTLRMNLDPFGS--YSEEDIWWALELSHLHTFVSSQPAGLDFQCSEG 180
Query: 530 GASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSH 589
G +LS GQ+Q + +AR+LLR+ +L+LDEAT+A+D ++ +QA + T +T++H
Sbjct: 181 GENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAH 240
Query: 590 RLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYH 625
RL+TI++ R++ +D+GV+ E + +L+ A+G ++
Sbjct: 241 RLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIFY 276
Score = 56.8 bits (131), Expect = 5e-07
Identities = 37/143 (25%), Positives = 70/143 (48%), Gaps = 7/143 (4%)
Query: 1051 GVKDKKDWVASGNFSMRDVEFCYPTRPS-QRVLKGIDLKMEAGKTIALVGSSGCGKSTIL 1109
G + + W G R+ Y RP VL+ + L + G+ + +VG +G GKS++
Sbjct: 34 GSRPPEGWPPRGEVEFRNYSVRY--RPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMT 91
Query: 1110 QLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRK 1169
R + G I +D ++ + + + LR QL ++ Q+P+L +L N+ D
Sbjct: 92 LCLFRILEAAKGEIRIDGLNV-ADIGLHDLRSQLTIIPQDPILFSGTLRMNL---DPFGS 147
Query: 1170 VTMHEIVAAAKAANIHSFIVSLP 1192
+ +I A + +++H+F+ S P
Sbjct: 148 YSEEDIWWALELSHLHTFVSSQP 170
>AB208954-1|BAD92191.1| 1533|Homo sapiens ATP-binding cassette,
sub-family C, member 3 isoform MRP3 variant protein.
Length = 1533
Score = 143 bits (346), Expect = 4e-33
Identities = 76/216 (35%), Positives = 128/216 (59%), Gaps = 3/216 (1%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
VL+ S+HV GE V +VG +G GKS++ L R+ + G + LRS
Sbjct: 1311 VLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRS 1370
Query: 471 SLGVVGQEPVLFRGTIYDNI-AIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGER 529
L ++ Q+P+LF GT+ N+ GS + E+I E+++ H F+S P G D E
Sbjct: 1371 QLTIIPQDPILFSGTLRMNLDPFGS--YSEEDIWWALELSHLHTFVSSQPAGLDFQCSEG 1428
Query: 530 GASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSH 589
G +LS GQ+Q + +AR+LLR+ +L+LDEAT+A+D ++ +QA + T +T++H
Sbjct: 1429 GENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAH 1488
Query: 590 RLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYH 625
RL+TI++ R++ +D+GV+ E + +L+ A+G ++
Sbjct: 1489 RLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIFY 1524
Score = 97.1 bits (231), Expect = 4e-19
Identities = 69/260 (26%), Positives = 121/260 (46%), Gaps = 21/260 (8%)
Query: 412 LKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSS 471
L I V G VA+VG GCGKS+++ L + G V ++ S
Sbjct: 650 LHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVH-------------MKGS 696
Query: 472 LGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGA 531
+ V Q+ + T+ +N+ G + Q + A D + +LP G T IGE+G
Sbjct: 697 VAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLAD-LEMLPGGDQTEIGEKGI 755
Query: 532 SLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV---QAALDRASVGRTTITVS 588
+LSGGQ+QR+++AR++ + + LLD+ SA+D H + + + G+T + V+
Sbjct: 756 NLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVT 815
Query: 589 HRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENKEPADIEPLIEEAD 648
H +S + D II + G + E G + L++ G + + +++ +E +
Sbjct: 816 HGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTALE 875
Query: 649 GDGDN----IEPTVPSRLDV 664
G D IE T+ + D+
Sbjct: 876 GAEDKEALLIEDTLSNHTDL 895
Score = 56.8 bits (131), Expect = 5e-07
Identities = 37/143 (25%), Positives = 70/143 (48%), Gaps = 7/143 (4%)
Query: 1051 GVKDKKDWVASGNFSMRDVEFCYPTRPS-QRVLKGIDLKMEAGKTIALVGSSGCGKSTIL 1109
G + + W G R+ Y RP VL+ + L + G+ + +VG +G GKS++
Sbjct: 1282 GSRPPEGWPPRGEVEFRNYSVRY--RPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMT 1339
Query: 1110 QLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRK 1169
R + G I +D ++ + + + LR QL ++ Q+P+L +L N+ D
Sbjct: 1340 LCLFRILEAAKGEIRIDGLNV-ADIGLHDLRSQLTIIPQDPILFSGTLRMNL---DPFGS 1395
Query: 1170 VTMHEIVAAAKAANIHSFIVSLP 1192
+ +I A + +++H+F+ S P
Sbjct: 1396 YSEEDIWWALELSHLHTFVSSQP 1418
>U63455-1|AAB36700.1| 1581|Homo sapiens sulfonylurea receptor protein.
Length = 1581
Score = 142 bits (345), Expect = 5e-33
Identities = 122/521 (23%), Positives = 236/521 (45%), Gaps = 21/521 (4%)
Query: 107 AMAIGMFISIGVSLVFCVLSFSLISWSALRQITRIRTLFLRSVLRQDMSWYDTDSEFNLA 166
AM + S+G+ V C+++ + W+ L+ R+ L ++ M +++T ++
Sbjct: 1064 AMVFTVLCSLGI--VLCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSIL 1121
Query: 167 SKMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPLGWQLTLACAAVMPFSVITSIAL 226
++ S + +I + + L +S ++++C+ + + + A++P +V+
Sbjct: 1122 NRFSSDCNTIDQHIPSTLECLSR---STLLCVSALAVISYVTPVFLVALLPLAVVCYFIQ 1178
Query: 227 SNYQTKS-SIREMESYSLAGKQAE--EILKSVRTIVAFGGENKEVERYRRLLEPAEEFGR 283
++ S +++++ + + E ++ + TI AF E ++LLE +
Sbjct: 1179 KYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAF---RYEARFQQKLLEYTDS-NN 1234
Query: 284 KRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVYSILFSVYMA 343
LF N W L + IG V ++S R+ G V L M
Sbjct: 1235 IASLFLTAAN--RW-LEVRMEYIGACVVLIAAVTSI-SNSLHRELSAGLVGLGLTYALMV 1290
Query: 344 TQSITFCVPHLEGFXXXXXXXXSIFHLIEREPK-IDSLQQKGLTPRRVV--GDILLEDVE 400
+ + + V +L I L++ E + + L L P+ G I ++++
Sbjct: 1291 SNYLNWMVRNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLS 1350
Query: 401 FCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXX 460
Y S + VLK + + PG+ + + G +G GKS+ R+ D G +
Sbjct: 1351 VRYDSSLK-PVLKHVNALISPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDI 1409
Query: 461 XXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPN 520
L S L ++ Q+PVLF GTI N+ + + + EIA + LP
Sbjct: 1410 RKLPLHTLPSRLSIILQDPVLFSGTIRFNLD-PERKCSDSTLWEALEIAQLKLVVKALPG 1468
Query: 521 GYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASV 580
G D +I E G + S GQ+Q +AR+ +R+ ++ ++DEAT+++D +E +Q + A
Sbjct: 1469 GLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFA 1528
Query: 581 GRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAK 621
RT +T++HR+ TI++AD +I + +G I+E E L+ K
Sbjct: 1529 DRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRK 1569
Score = 106 bits (255), Expect = 4e-22
Identities = 73/229 (31%), Positives = 113/229 (49%), Gaps = 17/229 (7%)
Query: 409 VKVLKGFSIHVKPGECVALVGSSGCGKSTVLQL----LQR---------LYDPQAGSVXX 455
+ L +I + G+ +VG GCGKS++L +Q+ L D + G
Sbjct: 693 IPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPS 752
Query: 456 XXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFI 515
R + Q+P L T+ +NI SP ++ + V E I
Sbjct: 753 PERETATDLDIRKRGPVAYASQKPWLLNATVEENIIFESP-FNKQRYKMVIEACSLQPDI 811
Query: 516 SLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPH-SERQVQAA 574
+LP+G T IGERG +LSGGQ+QRI++AR+L + V+ LD+ SALD H S+ +QA
Sbjct: 812 DILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLMQAG 871
Query: 575 LDR--ASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAK 621
+ RT + V+H+L + +AD II M G I +GT +D +++
Sbjct: 872 ILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSE 920
Score = 84.6 bits (200), Expect = 2e-15
Identities = 104/443 (23%), Positives = 193/443 (43%), Gaps = 37/443 (8%)
Query: 782 LYSVLFVVIAAVAGISMCL-QSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVG 840
+Y+++F V+ ++ GI +CL S T GLK+ RL ++ + FF ET +G
Sbjct: 1062 VYAMVFTVLCSL-GIVLCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFF--ETTPLG 1118
Query: 841 AICARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLMVGSI 900
+I R S D + + + + + + V L ISY + LVA LPL V
Sbjct: 1119 SILNRFSSDCNTIDQHIPSTLECLSRS-TLLCVSALAVISYVTPVFLVA--LLPLAVVCY 1175
Query: 901 WLEGIISQKA----QIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQK---FQDALK 953
+++ + Q+D+ + + A E V + T+++ E F QK + D+
Sbjct: 1176 FIQKYFRVASRDLQQLDDTTQLPLLSHFA-ETVEGLTTIRAFRYEARFQQKLLEYTDSNN 1234
Query: 954 TACVAVAYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVA---YGEMEYKLVLL-VNEAI 1009
A + + RW L V + ++ C + ++ + E+ LV L + A+
Sbjct: 1235 IASLFLTAANRW------LEVRMEYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTYAL 1288
Query: 1010 MYGAYMLGQSLVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKD--KKDWVASGNFSMR 1067
M Y L + + RI +++ + + + + K+W G ++
Sbjct: 1289 MVSNY-LNWMVRNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQ 1347
Query: 1068 DVEFCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDN 1127
++ Y + + VLK ++ + G+ I + G +G GKS+ F R D G I +D
Sbjct: 1348 NLSVRYDSS-LKPVLKHVNALISPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDG 1406
Query: 1128 RDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSF 1187
DIR L + L +L ++ Q+PVL ++ N+ D RK + + A + A +
Sbjct: 1407 IDIRK-LPLHTLPSRLSIILQDPVLFSGTIRFNL---DPERKCSDSTLWEALEIAQLKLV 1462
Query: 1188 IVSLP----KAVTEALEKAAKGR 1206
+ +LP +TE E ++G+
Sbjct: 1463 VKALPGGLDAIITEGGENFSQGQ 1485
Score = 39.9 bits (89), Expect = 0.056
Identities = 27/91 (29%), Positives = 40/91 (43%), Gaps = 4/91 (4%)
Query: 1159 ENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAVTEALEK----AAKGRTCITIAHR 1214
EN + G V + S+ A L+K A RT +TIAHR
Sbjct: 1479 ENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHR 1538
Query: 1215 LSTVKDADLICVIDKGKIVERGTHAELVSMK 1245
+ T+ ADL+ V+ +G I+E +L+S K
Sbjct: 1539 VHTILSADLVIVLKRGAILEFDKPEKLLSRK 1569
>U63421-1|AAB36699.1| 1581|Homo sapiens sulfonylurea receptor protein.
Length = 1581
Score = 142 bits (345), Expect = 5e-33
Identities = 122/521 (23%), Positives = 236/521 (45%), Gaps = 21/521 (4%)
Query: 107 AMAIGMFISIGVSLVFCVLSFSLISWSALRQITRIRTLFLRSVLRQDMSWYDTDSEFNLA 166
AM + S+G+ V C+++ + W+ L+ R+ L ++ M +++T ++
Sbjct: 1064 AMVFTVLCSLGI--VLCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSIL 1121
Query: 167 SKMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPLGWQLTLACAAVMPFSVITSIAL 226
++ S + +I + + L +S ++++C+ + + + A++P +V+
Sbjct: 1122 NRFSSDCNTIDQHIPSTLECLSR---STLLCVSALAVISYVTPVFLVALLPLAVVCYFIQ 1178
Query: 227 SNYQTKS-SIREMESYSLAGKQAE--EILKSVRTIVAFGGENKEVERYRRLLEPAEEFGR 283
++ S +++++ + + E ++ + TI AF E ++LLE +
Sbjct: 1179 KYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAF---RYEARFQQKLLEYTDS-NN 1234
Query: 284 KRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVYSILFSVYMA 343
LF N W L + IG V ++S R+ G V L M
Sbjct: 1235 IASLFLTAAN--RW-LEVRMEYIGACVVLIAAVTSI-SNSLHRELSAGLVGLGLTYALMV 1290
Query: 344 TQSITFCVPHLEGFXXXXXXXXSIFHLIEREPK-IDSLQQKGLTPRRVV--GDILLEDVE 400
+ + + V +L I L++ E + + L L P+ G I ++++
Sbjct: 1291 SNYLNWMVRNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLS 1350
Query: 401 FCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXX 460
Y S + VLK + + PG+ + + G +G GKS+ R+ D G +
Sbjct: 1351 VRYDSSLK-PVLKHVNALISPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDI 1409
Query: 461 XXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPN 520
L S L ++ Q+PVLF GTI N+ + + + EIA + LP
Sbjct: 1410 RKLPLHTLPSRLSIILQDPVLFSGTIRFNLD-PERKCSDSTLWEALEIAQLKLVVKALPG 1468
Query: 521 GYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASV 580
G D +I E G + S GQ+Q +AR+ +R+ ++ ++DEAT+++D +E +Q + A
Sbjct: 1469 GLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFA 1528
Query: 581 GRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAK 621
RT +T++HR+ TI++AD +I + +G I+E E L+ K
Sbjct: 1529 DRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRK 1569
Score = 106 bits (255), Expect = 4e-22
Identities = 73/229 (31%), Positives = 113/229 (49%), Gaps = 17/229 (7%)
Query: 409 VKVLKGFSIHVKPGECVALVGSSGCGKSTVLQL----LQR---------LYDPQAGSVXX 455
+ L +I + G+ +VG GCGKS++L +Q+ L D + G
Sbjct: 693 IPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPS 752
Query: 456 XXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFI 515
R + Q+P L T+ +NI SP ++ + V E I
Sbjct: 753 PERETATDLDIRKRGPVAYASQKPWLLNATVEENIIFESP-FNKQRYKMVIEACSLQPDI 811
Query: 516 SLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPH-SERQVQAA 574
+LP+G T IGERG +LSGGQ+QRI++AR+L + V+ LD+ SALD H S+ +QA
Sbjct: 812 DILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLMQAG 871
Query: 575 LDR--ASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAK 621
+ RT + V+H+L + +AD II M G I +GT +D +++
Sbjct: 872 ILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSE 920
Score = 84.6 bits (200), Expect = 2e-15
Identities = 104/443 (23%), Positives = 193/443 (43%), Gaps = 37/443 (8%)
Query: 782 LYSVLFVVIAAVAGISMCL-QSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVG 840
+Y+++F V+ ++ GI +CL S T GLK+ RL ++ + FF ET +G
Sbjct: 1062 VYAMVFTVLCSL-GIVLCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFF--ETTPLG 1118
Query: 841 AICARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLMVGSI 900
+I R S D + + + + + + V L ISY + LVA LPL V
Sbjct: 1119 SILNRFSSDCNTIDQHIPSTLECLSRS-TLLCVSALAVISYVTPVFLVA--LLPLAVVCY 1175
Query: 901 WLEGIISQKA----QIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQK---FQDALK 953
+++ + Q+D+ + + A E V + T+++ E F QK + D+
Sbjct: 1176 FIQKYFRVASRDLQQLDDTTQLPLLSHFA-ETVEGLTTIRAFRYEARFQQKLLEYTDSNN 1234
Query: 954 TACVAVAYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVA---YGEMEYKLVLL-VNEAI 1009
A + + RW L V + ++ C + ++ + E+ LV L + A+
Sbjct: 1235 IASLFLTAANRW------LEVRMEYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTYAL 1288
Query: 1010 MYGAYMLGQSLVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKD--KKDWVASGNFSMR 1067
M Y L + + RI +++ + + + + K+W G ++
Sbjct: 1289 MVSNY-LNWMVRNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQ 1347
Query: 1068 DVEFCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDN 1127
++ Y + + VLK ++ + G+ I + G +G GKS+ F R D G I +D
Sbjct: 1348 NLSVRYDSS-LKPVLKHVNALISPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDG 1406
Query: 1128 RDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSF 1187
DIR L + L +L ++ Q+PVL ++ N+ D RK + + A + A +
Sbjct: 1407 IDIRK-LPLHTLPSRLSIILQDPVLFSGTIRFNL---DPERKCSDSTLWEALEIAQLKLV 1462
Query: 1188 IVSLP----KAVTEALEKAAKGR 1206
+ +LP +TE E ++G+
Sbjct: 1463 VKALPGGLDAIITEGGENFSQGQ 1485
Score = 39.9 bits (89), Expect = 0.056
Identities = 27/91 (29%), Positives = 40/91 (43%), Gaps = 4/91 (4%)
Query: 1159 ENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAVTEALEK----AAKGRTCITIAHR 1214
EN + G V + S+ A L+K A RT +TIAHR
Sbjct: 1479 ENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHR 1538
Query: 1215 LSTVKDADLICVIDKGKIVERGTHAELVSMK 1245
+ T+ ADL+ V+ +G I+E +L+S K
Sbjct: 1539 VHTILSADLVIVLKRGAILEFDKPEKLLSRK 1569
>AF083552-1|AAC34668.1| 1527|Homo sapiens canalicular multispecific
organic anion transporter 2 protein.
Length = 1527
Score = 142 bits (345), Expect = 5e-33
Identities = 124/527 (23%), Positives = 241/527 (45%), Gaps = 25/527 (4%)
Query: 107 AMAIGMFISIGVSLVFCVLSFSLISWSALRQITRI-RTLFLRSVLRQDMSWYDTDSEFNL 165
++ +G++ ++G+ F V+ ++ + Q R+ L + +R S++DT +
Sbjct: 1009 SLRLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRI 1068
Query: 166 ASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPLGWQLTLACAAVMPFSVITSIA 225
+ S+++ + E + + ++ N ++ L L ++P +V+ ++
Sbjct: 1069 LNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMA---STPLFTVVILPLAVLYTLV 1125
Query: 226 LSNYQ-TKSSIREMESYSLAG--KQAEEILKSVRTIVAFGGENKEVERYRRLLEPAEEFG 282
Y T ++ +ES S + E + I A+ +++ E ++ +
Sbjct: 1126 QRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYN-RSRDFE----IISDTKVDA 1180
Query: 283 RKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVYSILFSVYM 342
+R + + + W L+ + +G + S+L VG S V
Sbjct: 1181 NQRSCYPYIISN-RW-LSIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTF 1238
Query: 343 ATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKI--DSLQQKGLTPRRVVGDILLEDVE 400
A + + LE P + S +G PR G++ +
Sbjct: 1239 ALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPR---GEVEFRNYS 1295
Query: 401 FCYPSRPEVK-VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXX 459
Y RP + VL+ S+HV GE V +VG +G GKS++ L R+ + G +
Sbjct: 1296 VRY--RPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLN 1353
Query: 460 XXXXXXSWLRSSLGVVGQEPVLFRGTIYDNI-AIGSPEATREEIQRVAEIAYAHDFISLL 518
+RS L ++ Q+P+LF GT+ N+ GS + E+I E+++ H F+S
Sbjct: 1354 VADIGLHDVRSQLTIIPQDPILFSGTLRMNLDPFGS--YSEEDIWWALELSHLHTFVSSQ 1411
Query: 519 PNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRA 578
P G D E G +LS GQ+Q + +AR+LLR+ +L+LDEAT+A+D ++ +QA +
Sbjct: 1412 PAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQ 1471
Query: 579 SVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYH 625
T +T++HRL+TI++ R++ +D+GV+ E + +L+ A+G ++
Sbjct: 1472 FDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIFY 1518
Score = 97.1 bits (231), Expect = 4e-19
Identities = 69/260 (26%), Positives = 121/260 (46%), Gaps = 21/260 (8%)
Query: 412 LKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSS 471
L I V G VA+VG GCGKS+++ L + G V ++ S
Sbjct: 644 LHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVH-------------MKGS 690
Query: 472 LGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGA 531
+ V Q+ + T+ +N+ G + Q + A D + +LP G T IGE+G
Sbjct: 691 VAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLAD-LEMLPGGDQTEIGEKGI 749
Query: 532 SLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV---QAALDRASVGRTTITVS 588
+LSGGQ+QR+++AR++ + + LLD+ SA+D H + + + G+T + V+
Sbjct: 750 NLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVT 809
Query: 589 HRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENKEPADIEPLIEEAD 648
H +S + D II + G + E G + L++ G + + +++ +E +
Sbjct: 810 HGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTALE 869
Query: 649 GDGDN----IEPTVPSRLDV 664
G D IE T+ + D+
Sbjct: 870 GAEDKEALLIEDTLSNHTDL 889
Score = 56.4 bits (130), Expect = 6e-07
Identities = 112/528 (21%), Positives = 200/528 (37%), Gaps = 69/528 (13%)
Query: 786 LFVVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICAR 845
++ + + G + L + + G++ L + ++ FFD T G I
Sbjct: 1014 VYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFD--TTPSGRILNC 1071
Query: 846 LSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLMVGSIWLEGI 905
S D V I ++L + + ++ ++ L V LPL V ++
Sbjct: 1072 FSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMA---STPLFTVVILPLAVLYTLVQRF 1128
Query: 906 ISQKAQIDERNAMESATAIAT---EAVVSIKTVQSLGVETVF---LQKFQDALKTACVAV 959
+ ++ +R S + I + E V +++ F DA + +C
Sbjct: 1129 YAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPY 1188
Query: 960 AYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEYK--LVLLVNEAIMYGAYMLG 1017
RW L + + F+ C ++ A+ G LV L + + L
Sbjct: 1189 IISNRW------LSIGVEFVGNC-VVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALN 1241
Query: 1018 QSLVYAPSLNTAKACGARILSIIQRQPKIHNAV-GVKDKKDWVASGNFSMRDVEFCYPTR 1076
+ L + R+ + + + V G + + W G R+ Y R
Sbjct: 1242 WMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRY--R 1299
Query: 1077 PS-QRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDN-------- 1127
P VL+ + L + G+ + +VG +G GKS++ R + G I +D
Sbjct: 1300 PGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGL 1359
Query: 1128 RDIRSALT-IPR--------LRRQL---GVVQQEPVLLDRSLAE--------------NI 1161
D+RS LT IP+ LR L G +E + L+
Sbjct: 1360 HDVRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQC 1419
Query: 1162 AYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAV------TEALEKAA---KGRTC--IT 1210
+ G N V ++V A+A S I+ L +A T+ L +A + TC +T
Sbjct: 1420 SEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLT 1479
Query: 1211 IAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRMCRGQNMA 1258
IAHRL+T+ D + V+DKG + E + A L++ +G ++ M R +A
Sbjct: 1480 IAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIFYGMARDAGLA 1527
>L05628-1|AAB46616.1| 1531|Homo sapiens multidrug
resistance-associated protein protein.
Length = 1531
Score = 142 bits (344), Expect = 7e-33
Identities = 131/525 (24%), Positives = 243/525 (46%), Gaps = 23/525 (4%)
Query: 110 IGMFISIGVSLVFCVLSFSL-ISWSALRQITRIRTLFLRSVLRQDMSWYDTDSEFNLASK 168
+ ++ ++G+S V +S+ +S + + L S+LR MS+++ NL ++
Sbjct: 1016 LSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNR 1075
Query: 169 MSENLMSIKEGMGEKLAVVSNLVGT--SVICLCTAFPLGWQLTLACAAVMPFSVITSIAL 226
S+ L ++ + E V+ +G+ +VI C L +A + P +I
Sbjct: 1076 FSKELDTVDSMIPE---VIKMFMGSLFNVIGACIVILLA--TPIAAIIIPPLGLIYFFVQ 1130
Query: 227 SNYQTKS-SIREMESYSLAGKQAE--EILKSVRTIVAFGGENKEVERYRRLLEPAEEFGR 283
Y S ++ +ES S + + E L V I AF +E ER+ + + +
Sbjct: 1131 RFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAF----EEQERFIHQSDLKVDENQ 1186
Query: 284 KRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVYSILFSVYMA 343
K + + N W L L +G + + +L VG S+ +S+ +
Sbjct: 1187 KAYYPSIVAN--RW-LAVRLECVGNCIVLFAALFAVISRHSLSAGLVGL--SVSYSLQVT 1241
Query: 344 TQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPRRVVGDILLEDVEFCY 403
T + + V + E E + Q+ P +E +C
Sbjct: 1242 TY-LNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCL 1300
Query: 404 PSRPEVK-VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXX 462
R ++ VL+ ++ + GE V +VG +G GKS++ L R+ + G +
Sbjct: 1301 RYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAK 1360
Query: 463 XXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGY 522
LR + ++ Q+PVLF G++ N+ S + + EE+ E+A+ DF+S LP+
Sbjct: 1361 IGLHDLRFKITIIPQDPVLFSGSLRMNLDPFS-QYSDEEVWTSLELAHLKDFVSALPDKL 1419
Query: 523 DTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGR 582
D E G +LS GQ+Q + +AR+LLR+ +L+LDEAT+A+D ++ +Q+ +
Sbjct: 1420 DHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDC 1479
Query: 583 TTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKL 627
T +T++HRL+TI++ R+I +D+G I E G DL++ +G ++ +
Sbjct: 1480 TVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSM 1524
Score = 119 bits (287), Expect = 6e-26
Identities = 124/550 (22%), Positives = 242/550 (44%), Gaps = 33/550 (6%)
Query: 102 IDDAKAMAI-GMFISIGVSLVFCVLSFSLISWSALRQIT--RIRTLFLRSVLRQDMSWYD 158
++D KA G F ++ + + C+ + L + + ++ RI+T + +V R+ + +
Sbjct: 353 VNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITN 412
Query: 159 TDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPLGW----QLTLACAA 214
+ + + ++ NLMS+ LA N++ ++ + + A L W LA A
Sbjct: 413 SARKSSTVGEIV-NLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVA 471
Query: 215 VMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAFGGENKEVERYRRL 274
VM V + ++ + M+S K EIL ++ + + E ++ +
Sbjct: 472 VMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAI 531
Query: 275 LEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVY 334
+ + +K + +G F WV T L A+ ++ + +++ +N+ V
Sbjct: 532 RQEELKVLKKSAYLSAVGT-FTWVCTPFLVAL-CTFAVYVTIDE----NNILDAQTAFVS 585
Query: 335 SILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPRRVVGDI 394
LF++ +I V IF L E + DS++++ + I
Sbjct: 586 LALFNILRFPLNILPMVISSIVQASVSLKRLRIF-LSHEELEPDSIERRPVKDGGGTNSI 644
Query: 395 LLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVX 454
+ + F + +R + L G + + G VA+VG GCGKS++L L D G V
Sbjct: 645 TVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVA 703
Query: 455 XXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDF 514
++ S+ V Q+ + ++ +NI G + + V +
Sbjct: 704 -------------IKGSVAYVPQQAWIQNDSLRENILFGC-QLEEPYYRSVIQACALLPD 749
Query: 515 ISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QA 573
+ +LP+G T IGE+G +LSGGQKQR+++AR++ + L D+ SA+D H + + +
Sbjct: 750 LEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFEN 809
Query: 574 ALDRASV--GRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTG 631
+ + +T I V+H +S + D II M G I E G++++L+ G + + + T
Sbjct: 810 VIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTY 869
Query: 632 NENKEPADIE 641
++ D E
Sbjct: 870 ASTEQEQDAE 879
Score = 48.8 bits (111), Expect = 1e-04
Identities = 35/136 (25%), Positives = 68/136 (50%), Gaps = 7/136 (5%)
Query: 1058 WVASGNFSMRDVEFCYPTRPS-QRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFY 1116
W G R+ +C R VL+ I++ + G+ + +VG +G GKS++ R
Sbjct: 1287 WPQVGRVEFRN--YCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRIN 1344
Query: 1117 DPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIV 1176
+ G I +D +I + + + LR ++ ++ Q+PVL SL N+ D + + E+
Sbjct: 1345 ESAEGEIIIDGINI-AKIGLHDLRFKITIIPQDPVLFSGSLRMNL---DPFSQYSDEEVW 1400
Query: 1177 AAAKAANIHSFIVSLP 1192
+ + A++ F+ +LP
Sbjct: 1401 TSLELAHLKDFVSALP 1416
Score = 46.4 bits (105), Expect = 6e-04
Identities = 37/143 (25%), Positives = 67/143 (46%), Gaps = 18/143 (12%)
Query: 1122 FIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKA 1181
F + + ++ ++L + L+ V P LD AE G N V ++V A+A
Sbjct: 1391 FSQYSDEEVWTSLELAHLK---DFVSALPDKLDHECAE----GGENLSVGQRQLVCLARA 1443
Query: 1182 ANIHSFIVSLPKA-----------VTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKG 1230
+ I+ L +A + + + T +TIAHRL+T+ D + V+DKG
Sbjct: 1444 LLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKG 1503
Query: 1231 KIVERGTHAELVSMKGHYWRMCR 1253
+I E G ++L+ +G ++ M +
Sbjct: 1504 EIQEYGAPSDLLQQRGLFYSMAK 1526
Score = 39.9 bits (89), Expect = 0.056
Identities = 59/295 (20%), Positives = 114/295 (38%), Gaps = 8/295 (2%)
Query: 834 KETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFL 893
++++TVG I +S D I +I V++ L L +
Sbjct: 415 RKSSTVGEIVNLMSVDAQRFMDLATY-INMIWSAPLQVILALYLLWLNLGPSVLAGVAVM 473
Query: 894 PLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALK 953
LMV + + ++ Q+ + ++ + E + IK ++ E F K A++
Sbjct: 474 VLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVL-AIR 532
Query: 954 TACVAVAYKTRWRGLVYGLG-VYIPFM-AYCSATVYGAVLVAYGEMEYKLVLLVNEAIM- 1010
+ V K+ + V V PF+ A C+ VY V + + V+ A+
Sbjct: 533 QEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVY--VTIDENNILDAQTAFVSLALFN 590
Query: 1011 YGAYMLGQSLVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVE 1070
+ L + S+ A R+ + + +++ + KD + + ++R+
Sbjct: 591 ILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNAT 650
Query: 1071 FCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIEL 1125
F + R L GI + G +A+VG GCGKS++L D G + +
Sbjct: 651 FTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAI 704
Score = 36.7 bits (81), Expect = 0.53
Identities = 17/50 (34%), Positives = 28/50 (56%)
Query: 1204 KGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRMCR 1253
K +T I + H +S + D+I V+ GKI E G++ EL++ G + R
Sbjct: 818 KNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLR 867
>EF419769-1|ABN79590.1| 1531|Homo sapiens ATP-binding cassette,
sub-family C (CFTR/MRP), member 1 protein.
Length = 1531
Score = 142 bits (344), Expect = 7e-33
Identities = 131/525 (24%), Positives = 243/525 (46%), Gaps = 23/525 (4%)
Query: 110 IGMFISIGVSLVFCVLSFSL-ISWSALRQITRIRTLFLRSVLRQDMSWYDTDSEFNLASK 168
+ ++ ++G+S V +S+ +S + + L S+LR MS+++ NL ++
Sbjct: 1016 LSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNR 1075
Query: 169 MSENLMSIKEGMGEKLAVVSNLVGT--SVICLCTAFPLGWQLTLACAAVMPFSVITSIAL 226
S+ L ++ + E V+ +G+ +VI C L +A + P +I
Sbjct: 1076 FSKELDTVDSMIPE---VIKMFMGSLFNVIGACIVILLA--TPIAAIIIPPLGLIYFFVQ 1130
Query: 227 SNYQTKS-SIREMESYSLAGKQAE--EILKSVRTIVAFGGENKEVERYRRLLEPAEEFGR 283
Y S ++ +ES S + + E L V I AF +E ER+ + + +
Sbjct: 1131 RFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAF----EEQERFIHQSDLKVDENQ 1186
Query: 284 KRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVYSILFSVYMA 343
K + + N W L L +G + + +L VG S+ +S+ +
Sbjct: 1187 KAYYPSIVAN--RW-LAVRLECVGNCIVLFAALFAVISRHSLSAGLVGL--SVSYSLQVT 1241
Query: 344 TQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPRRVVGDILLEDVEFCY 403
T + + V + E E + Q+ P +E +C
Sbjct: 1242 TY-LNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCL 1300
Query: 404 PSRPEVK-VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXX 462
R ++ VL+ ++ + GE V +VG +G GKS++ L R+ + G +
Sbjct: 1301 RYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAK 1360
Query: 463 XXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGY 522
LR + ++ Q+PVLF G++ N+ S + + EE+ E+A+ DF+S LP+
Sbjct: 1361 IGLHDLRFKITIIPQDPVLFSGSLRMNLDPFS-QYSDEEVWTSLELAHLKDFVSALPDKL 1419
Query: 523 DTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGR 582
D E G +LS GQ+Q + +AR+LLR+ +L+LDEAT+A+D ++ +Q+ +
Sbjct: 1420 DHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDC 1479
Query: 583 TTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKL 627
T +T++HRL+TI++ R+I +D+G I E G DL++ +G ++ +
Sbjct: 1480 TVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSM 1524
Score = 119 bits (287), Expect = 6e-26
Identities = 124/550 (22%), Positives = 242/550 (44%), Gaps = 33/550 (6%)
Query: 102 IDDAKAMAI-GMFISIGVSLVFCVLSFSLISWSALRQIT--RIRTLFLRSVLRQDMSWYD 158
++D KA G F ++ + + C+ + L + + ++ RI+T + +V R+ + +
Sbjct: 353 VNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITN 412
Query: 159 TDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPLGW----QLTLACAA 214
+ + + ++ NLMS+ LA N++ ++ + + A L W LA A
Sbjct: 413 SARKSSTVGEIV-NLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVA 471
Query: 215 VMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAFGGENKEVERYRRL 274
VM V + ++ + M+S K EIL ++ + + E ++ +
Sbjct: 472 VMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAI 531
Query: 275 LEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVY 334
+ + +K + +G F WV T L A+ ++ + +++ +N+ V
Sbjct: 532 RQEELKVLKKSAYLSAVGT-FTWVCTPFLVAL-CTFAVYVTIDE----NNILDAQTAFVS 585
Query: 335 SILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPRRVVGDI 394
LF++ +I V IF L E + DS++++ + I
Sbjct: 586 LALFNILRFPLNILPMVISSIVQASVSLKRLRIF-LSHEELEPDSIERRPVKDGGGTNSI 644
Query: 395 LLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVX 454
+ + F + +R + L G + + G VA+VG GCGKS++L L D G V
Sbjct: 645 TVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVA 703
Query: 455 XXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDF 514
++ S+ V Q+ + ++ +NI G + + V +
Sbjct: 704 -------------IKGSVAYVPQQAWIQNDSLRENILFGC-QLEEPYYRSVIQACALLPD 749
Query: 515 ISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QA 573
+ +LP+G T IGE+G +LSGGQKQR+++AR++ + L D+ SA+D H + + +
Sbjct: 750 LEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFEN 809
Query: 574 ALDRASV--GRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTG 631
+ + +T I V+H +S + D II M G I E G++++L+ G + + + T
Sbjct: 810 VIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTY 869
Query: 632 NENKEPADIE 641
++ D E
Sbjct: 870 ASTEQEQDAE 879
Score = 48.8 bits (111), Expect = 1e-04
Identities = 35/136 (25%), Positives = 68/136 (50%), Gaps = 7/136 (5%)
Query: 1058 WVASGNFSMRDVEFCYPTRPS-QRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFY 1116
W G R+ +C R VL+ I++ + G+ + +VG +G GKS++ R
Sbjct: 1287 WPQVGRVEFRN--YCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRIN 1344
Query: 1117 DPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIV 1176
+ G I +D +I + + + LR ++ ++ Q+PVL SL N+ D + + E+
Sbjct: 1345 ESAEGEIIIDGINI-AKIGLHDLRFKITIIPQDPVLFSGSLRMNL---DPFSQYSDEEVW 1400
Query: 1177 AAAKAANIHSFIVSLP 1192
+ + A++ F+ +LP
Sbjct: 1401 TSLELAHLKDFVSALP 1416
Score = 46.4 bits (105), Expect = 6e-04
Identities = 37/143 (25%), Positives = 67/143 (46%), Gaps = 18/143 (12%)
Query: 1122 FIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKA 1181
F + + ++ ++L + L+ V P LD AE G N V ++V A+A
Sbjct: 1391 FSQYSDEEVWTSLELAHLK---DFVSALPDKLDHECAE----GGENLSVGQRQLVCLARA 1443
Query: 1182 ANIHSFIVSLPKA-----------VTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKG 1230
+ I+ L +A + + + T +TIAHRL+T+ D + V+DKG
Sbjct: 1444 LLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKG 1503
Query: 1231 KIVERGTHAELVSMKGHYWRMCR 1253
+I E G ++L+ +G ++ M +
Sbjct: 1504 EIQEYGAPSDLLQQRGLFYSMAK 1526
Score = 39.9 bits (89), Expect = 0.056
Identities = 59/295 (20%), Positives = 114/295 (38%), Gaps = 8/295 (2%)
Query: 834 KETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFL 893
++++TVG I +S D I +I V++ L L +
Sbjct: 415 RKSSTVGEIVNLMSVDAQRFMDLATY-INMIWSAPLQVILALYLLWLNLGPSVLAGVAVM 473
Query: 894 PLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALK 953
LMV + + ++ Q+ + ++ + E + IK ++ E F K A++
Sbjct: 474 VLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVL-AIR 532
Query: 954 TACVAVAYKTRWRGLVYGLG-VYIPFM-AYCSATVYGAVLVAYGEMEYKLVLLVNEAIM- 1010
+ V K+ + V V PF+ A C+ VY V + + V+ A+
Sbjct: 533 QEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVY--VTIDENNILDAQTAFVSLALFN 590
Query: 1011 YGAYMLGQSLVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVE 1070
+ L + S+ A R+ + + +++ + KD + + ++R+
Sbjct: 591 ILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNAT 650
Query: 1071 FCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIEL 1125
F + R L GI + G +A+VG GCGKS++L D G + +
Sbjct: 651 FTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAI 704
Score = 36.7 bits (81), Expect = 0.53
Identities = 17/50 (34%), Positives = 28/50 (56%)
Query: 1204 KGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRMCR 1253
K +T I + H +S + D+I V+ GKI E G++ EL++ G + R
Sbjct: 818 KNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLR 867
>AF022853-5|AAB83982.1| 1400|Homo sapiens multidrug resistance protein
protein.
Length = 1400
Score = 142 bits (344), Expect = 7e-33
Identities = 131/525 (24%), Positives = 243/525 (46%), Gaps = 23/525 (4%)
Query: 110 IGMFISIGVSLVFCVLSFSL-ISWSALRQITRIRTLFLRSVLRQDMSWYDTDSEFNLASK 168
+ ++ ++G+S V +S+ +S + + L S+LR MS+++ NL ++
Sbjct: 885 LSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNR 944
Query: 169 MSENLMSIKEGMGEKLAVVSNLVGT--SVICLCTAFPLGWQLTLACAAVMPFSVITSIAL 226
S+ L ++ + E V+ +G+ +VI C L +A + P +I
Sbjct: 945 FSKELDTVDSMIPE---VIKMFMGSLFNVIGACIVILLA--TPIAAIIIPPLGLIYFFVQ 999
Query: 227 SNYQTKS-SIREMESYSLAGKQAE--EILKSVRTIVAFGGENKEVERYRRLLEPAEEFGR 283
Y S ++ +ES S + + E L V I AF +E ER+ + + +
Sbjct: 1000 RFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAF----EEQERFIHQSDLKVDENQ 1055
Query: 284 KRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVYSILFSVYMA 343
K + + N W L L +G + + +L VG S+ +S+ +
Sbjct: 1056 KAYYPSIVAN--RW-LAVRLECVGNCIVLFAALFAVISRHSLSAGLVGL--SVSYSLQVT 1110
Query: 344 TQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPRRVVGDILLEDVEFCY 403
T + + V + E E + Q+ P +E +C
Sbjct: 1111 TY-LNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCL 1169
Query: 404 PSRPEVK-VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXX 462
R ++ VL+ ++ + GE V +VG +G GKS++ L R+ + G +
Sbjct: 1170 RYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAK 1229
Query: 463 XXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGY 522
LR + ++ Q+PVLF G++ N+ S + + EE+ E+A+ DF+S LP+
Sbjct: 1230 IGLHDLRFKITIIPQDPVLFSGSLRMNLDPFS-QYSDEEVWTSLELAHLKDFVSALPDKL 1288
Query: 523 DTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGR 582
D E G +LS GQ+Q + +AR+LLR+ +L+LDEAT+A+D ++ +Q+ +
Sbjct: 1289 DHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDC 1348
Query: 583 TTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKL 627
T +T++HRL+TI++ R+I +D+G I E G DL++ +G ++ +
Sbjct: 1349 TVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSM 1393
Score = 56.0 bits (129), Expect = 8e-07
Identities = 77/374 (20%), Positives = 153/374 (40%), Gaps = 16/374 (4%)
Query: 102 IDDAKAMAI-GMFISIGVSLVFCVLSFSLISWSALRQIT--RIRTLFLRSVLRQDMSWYD 158
++D KA G F ++ + + C+ + L + + ++ RI+T + +V R+ + +
Sbjct: 337 VNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITN 396
Query: 159 TDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPLGW----QLTLACAA 214
+ + + ++ NLMS+ LA N++ ++ + + A L W LA A
Sbjct: 397 SARKSSTVGEIV-NLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVA 455
Query: 215 VMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAFGGENKEVERYRRL 274
VM V + ++ + M+S K EIL ++ + + E ++ +
Sbjct: 456 VMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAI 515
Query: 275 LEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVY 334
+ + +K + +G F WV T L A+ ++ + +++ +N+ V
Sbjct: 516 RQEELKVLKKSAYLSAVGT-FTWVCTPFLVAL-CTFAVYVTIDE----NNILDAQTAFVS 569
Query: 335 SILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPRRVVGDI 394
LF++ +I V IF L E + DS++++ + I
Sbjct: 570 LALFNILRFPLNILPMVISSIVQASVSLKRLRIF-LSHEELEPDSIERRPVKDGGGTNSI 628
Query: 395 LLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVX 454
+ + F + +R + L G + + G VA+VG GCGKS++L L D G V
Sbjct: 629 TVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVA 687
Query: 455 XXXXXXXXXXXSWL 468
S+L
Sbjct: 688 IKTRILVTHSMSYL 701
Score = 48.8 bits (111), Expect = 1e-04
Identities = 35/136 (25%), Positives = 68/136 (50%), Gaps = 7/136 (5%)
Query: 1058 WVASGNFSMRDVEFCYPTRPS-QRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFY 1116
W G R+ +C R VL+ I++ + G+ + +VG +G GKS++ R
Sbjct: 1156 WPQVGRVEFRN--YCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRIN 1213
Query: 1117 DPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIV 1176
+ G I +D +I + + + LR ++ ++ Q+PVL SL N+ D + + E+
Sbjct: 1214 ESAEGEIIIDGINI-AKIGLHDLRFKITIIPQDPVLFSGSLRMNL---DPFSQYSDEEVW 1269
Query: 1177 AAAKAANIHSFIVSLP 1192
+ + A++ F+ +LP
Sbjct: 1270 TSLELAHLKDFVSALP 1285
Score = 46.4 bits (105), Expect = 6e-04
Identities = 37/143 (25%), Positives = 67/143 (46%), Gaps = 18/143 (12%)
Query: 1122 FIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKA 1181
F + + ++ ++L + L+ V P LD AE G N V ++V A+A
Sbjct: 1260 FSQYSDEEVWTSLELAHLK---DFVSALPDKLDHECAE----GGENLSVGQRQLVCLARA 1312
Query: 1182 ANIHSFIVSLPKA-----------VTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKG 1230
+ I+ L +A + + + T +TIAHRL+T+ D + V+DKG
Sbjct: 1313 LLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKG 1372
Query: 1231 KIVERGTHAELVSMKGHYWRMCR 1253
+I E G ++L+ +G ++ M +
Sbjct: 1373 EIQEYGAPSDLLQQRGLFYSMAK 1395
Score = 41.5 bits (93), Expect = 0.018
Identities = 60/298 (20%), Positives = 115/298 (38%), Gaps = 8/298 (2%)
Query: 834 KETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFL 893
++++TVG I +S D I +I V++ L L +
Sbjct: 399 RKSSTVGEIVNLMSVDAQRFMDLATY-INMIWSAPLQVILALYLLWLNLGPSVLAGVAVM 457
Query: 894 PLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALK 953
LMV + + ++ Q+ + ++ + E + IK ++ E F K A++
Sbjct: 458 VLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVL-AIR 516
Query: 954 TACVAVAYKTRWRGLVYGLG-VYIPFM-AYCSATVYGAVLVAYGEMEYKLVLLVNEAIM- 1010
+ V K+ + V V PF+ A C+ VY V + + V+ A+
Sbjct: 517 QEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVY--VTIDENNILDAQTAFVSLALFN 574
Query: 1011 YGAYMLGQSLVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVE 1070
+ L + S+ A R+ + + +++ + KD + + ++R+
Sbjct: 575 ILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNAT 634
Query: 1071 FCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNR 1128
F + R L GI + G +A+VG GCGKS++L D G + + R
Sbjct: 635 FTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKTR 691
Score = 37.1 bits (82), Expect = 0.40
Identities = 18/60 (30%), Positives = 32/60 (53%)
Query: 582 RTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENKEPADIE 641
+T I V+H +S + D II M G I E G++++L+ G + + + T ++ D E
Sbjct: 689 KTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAE 748
Score = 35.5 bits (78), Expect = 1.2
Identities = 20/68 (29%), Positives = 35/68 (51%)
Query: 1186 SFIVSLPKAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMK 1245
S ++S A + +E +T I + H +S + D+I V+ GKI E G++ EL++
Sbjct: 669 SSLLSALLAEMDKVEGHVAIKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARD 728
Query: 1246 GHYWRMCR 1253
G + R
Sbjct: 729 GAFAEFLR 736
>AF022853-4|AAB83981.1| 1456|Homo sapiens multidrug resistance protein
protein.
Length = 1456
Score = 142 bits (344), Expect = 7e-33
Identities = 131/525 (24%), Positives = 243/525 (46%), Gaps = 23/525 (4%)
Query: 110 IGMFISIGVSLVFCVLSFSL-ISWSALRQITRIRTLFLRSVLRQDMSWYDTDSEFNLASK 168
+ ++ ++G+S V +S+ +S + + L S+LR MS+++ NL ++
Sbjct: 941 LSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNR 1000
Query: 169 MSENLMSIKEGMGEKLAVVSNLVGT--SVICLCTAFPLGWQLTLACAAVMPFSVITSIAL 226
S+ L ++ + E V+ +G+ +VI C L +A + P +I
Sbjct: 1001 FSKELDTVDSMIPE---VIKMFMGSLFNVIGACIVILLA--TPIAAIIIPPLGLIYFFVQ 1055
Query: 227 SNYQTKS-SIREMESYSLAGKQAE--EILKSVRTIVAFGGENKEVERYRRLLEPAEEFGR 283
Y S ++ +ES S + + E L V I AF +E ER+ + + +
Sbjct: 1056 RFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAF----EEQERFIHQSDLKVDENQ 1111
Query: 284 KRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVYSILFSVYMA 343
K + + N W L L +G + + +L VG S+ +S+ +
Sbjct: 1112 KAYYPSIVAN--RW-LAVRLECVGNCIVLFAALFAVISRHSLSAGLVGL--SVSYSLQVT 1166
Query: 344 TQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPRRVVGDILLEDVEFCY 403
T + + V + E E + Q+ P +E +C
Sbjct: 1167 TY-LNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCL 1225
Query: 404 PSRPEVK-VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXX 462
R ++ VL+ ++ + GE V +VG +G GKS++ L R+ + G +
Sbjct: 1226 RYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAK 1285
Query: 463 XXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGY 522
LR + ++ Q+PVLF G++ N+ S + + EE+ E+A+ DF+S LP+
Sbjct: 1286 IGLHDLRFKITIIPQDPVLFSGSLRMNLDPFS-QYSDEEVWTSLELAHLKDFVSALPDKL 1344
Query: 523 DTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGR 582
D E G +LS GQ+Q + +AR+LLR+ +L+LDEAT+A+D ++ +Q+ +
Sbjct: 1345 DHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDC 1404
Query: 583 TTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKL 627
T +T++HRL+TI++ R+I +D+G I E G DL++ +G ++ +
Sbjct: 1405 TVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSM 1449
Score = 65.7 bits (153), Expect = 1e-09
Identities = 35/116 (30%), Positives = 64/116 (55%), Gaps = 3/116 (2%)
Query: 529 RGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASV--GRTTI 585
+G +LSGGQKQR+++AR++ + L D+ SA+D H + + + + + +T I
Sbjct: 689 KGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRI 748
Query: 586 TVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENKEPADIE 641
V+H +S + D II M G I E G++++L+ G + + + T ++ D E
Sbjct: 749 LVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAE 804
Score = 55.2 bits (127), Expect = 1e-06
Identities = 75/359 (20%), Positives = 150/359 (41%), Gaps = 16/359 (4%)
Query: 102 IDDAKAMAI-GMFISIGVSLVFCVLSFSLISWSALRQIT--RIRTLFLRSVLRQDMSWYD 158
++D KA G F ++ + + C+ + L + + ++ RI+T + +V R+ + +
Sbjct: 337 VNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITN 396
Query: 159 TDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPLGW----QLTLACAA 214
+ + + ++ NLMS+ LA N++ ++ + + A L W LA A
Sbjct: 397 SARKSSTVGEIV-NLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVA 455
Query: 215 VMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAFGGENKEVERYRRL 274
VM V + ++ + M+S K EIL ++ + + E ++ +
Sbjct: 456 VMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAI 515
Query: 275 LEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVY 334
+ + +K + +G F WV T L A+ ++ + +++ +N+ V
Sbjct: 516 RQEELKVLKKSAYLSAVGT-FTWVCTPFLVAL-CTFAVYVTIDE----NNILDAQTAFVS 569
Query: 335 SILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPRRVVGDI 394
LF++ +I V IF L E + DS++++ + I
Sbjct: 570 LALFNILRFPLNILPMVISSIVQASVSLKRLRIF-LSHEELEPDSIERRPVKDGGGTNSI 628
Query: 395 LLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSV 453
+ + F + +R + L G + + G VA+VG GCGKS++L L D G V
Sbjct: 629 TVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHV 686
Score = 48.8 bits (111), Expect = 1e-04
Identities = 87/423 (20%), Positives = 163/423 (38%), Gaps = 32/423 (7%)
Query: 834 KETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFL 893
++++TVG I +S D I +I V++ L L +
Sbjct: 399 RKSSTVGEIVNLMSVDAQRFMDLATY-INMIWSAPLQVILALYLLWLNLGPSVLAGVAVM 457
Query: 894 PLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALK 953
LMV + + ++ Q+ + ++ + E + IK ++ E F K A++
Sbjct: 458 VLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVL-AIR 516
Query: 954 TACVAVAYKTRWRGLVYGLG-VYIPFM-AYCSATVYGAVLVAYGEMEYKLVLLVNEAIM- 1010
+ V K+ + V V PF+ A C+ VY V + + V+ A+
Sbjct: 517 QEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVY--VTIDENNILDAQTAFVSLALFN 574
Query: 1011 YGAYMLGQSLVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVE 1070
+ L + S+ A R+ + + +++ + KD + + ++R+
Sbjct: 575 ILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNAT 634
Query: 1071 FCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDI 1130
F + R L GI + G +A+VG GCGKS++L D G + + ++
Sbjct: 635 FTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGVNL 693
Query: 1131 RSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVS 1190
Q++ V L R++ N D V A +I ++
Sbjct: 694 SGG-------------QKQRVSLARAVYSN---ADIYLFDDPLSAVDAHVGKHIFENVIG 737
Query: 1191 LPKAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWR 1250
PK + K +T I + H +S + D+I V+ GKI E G++ EL++ G +
Sbjct: 738 -PKGM-------LKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAE 789
Query: 1251 MCR 1253
R
Sbjct: 790 FLR 792
Score = 48.8 bits (111), Expect = 1e-04
Identities = 35/136 (25%), Positives = 68/136 (50%), Gaps = 7/136 (5%)
Query: 1058 WVASGNFSMRDVEFCYPTRPS-QRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFY 1116
W G R+ +C R VL+ I++ + G+ + +VG +G GKS++ R
Sbjct: 1212 WPQVGRVEFRN--YCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRIN 1269
Query: 1117 DPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIV 1176
+ G I +D +I + + + LR ++ ++ Q+PVL SL N+ D + + E+
Sbjct: 1270 ESAEGEIIIDGINI-AKIGLHDLRFKITIIPQDPVLFSGSLRMNL---DPFSQYSDEEVW 1325
Query: 1177 AAAKAANIHSFIVSLP 1192
+ + A++ F+ +LP
Sbjct: 1326 TSLELAHLKDFVSALP 1341
Score = 46.4 bits (105), Expect = 6e-04
Identities = 37/143 (25%), Positives = 67/143 (46%), Gaps = 18/143 (12%)
Query: 1122 FIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKA 1181
F + + ++ ++L + L+ V P LD AE G N V ++V A+A
Sbjct: 1316 FSQYSDEEVWTSLELAHLK---DFVSALPDKLDHECAE----GGENLSVGQRQLVCLARA 1368
Query: 1182 ANIHSFIVSLPKA-----------VTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKG 1230
+ I+ L +A + + + T +TIAHRL+T+ D + V+DKG
Sbjct: 1369 LLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKG 1428
Query: 1231 KIVERGTHAELVSMKGHYWRMCR 1253
+I E G ++L+ +G ++ M +
Sbjct: 1429 EIQEYGAPSDLLQQRGLFYSMAK 1451
>AF022853-3|AAB83980.1| 1459|Homo sapiens multidrug resistance protein
protein.
Length = 1459
Score = 142 bits (344), Expect = 7e-33
Identities = 131/525 (24%), Positives = 243/525 (46%), Gaps = 23/525 (4%)
Query: 110 IGMFISIGVSLVFCVLSFSL-ISWSALRQITRIRTLFLRSVLRQDMSWYDTDSEFNLASK 168
+ ++ ++G+S V +S+ +S + + L S+LR MS+++ NL ++
Sbjct: 944 LSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNR 1003
Query: 169 MSENLMSIKEGMGEKLAVVSNLVGT--SVICLCTAFPLGWQLTLACAAVMPFSVITSIAL 226
S+ L ++ + E V+ +G+ +VI C L +A + P +I
Sbjct: 1004 FSKELDTVDSMIPE---VIKMFMGSLFNVIGACIVILLA--TPIAAIIIPPLGLIYFFVQ 1058
Query: 227 SNYQTKS-SIREMESYSLAGKQAE--EILKSVRTIVAFGGENKEVERYRRLLEPAEEFGR 283
Y S ++ +ES S + + E L V I AF +E ER+ + + +
Sbjct: 1059 RFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAF----EEQERFIHQSDLKVDENQ 1114
Query: 284 KRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVYSILFSVYMA 343
K + + N W L L +G + + +L VG S+ +S+ +
Sbjct: 1115 KAYYPSIVAN--RW-LAVRLECVGNCIVLFAALFAVISRHSLSAGLVGL--SVSYSLQVT 1169
Query: 344 TQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPRRVVGDILLEDVEFCY 403
T + + V + E E + Q+ P +E +C
Sbjct: 1170 TY-LNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCL 1228
Query: 404 PSRPEVK-VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXX 462
R ++ VL+ ++ + GE V +VG +G GKS++ L R+ + G +
Sbjct: 1229 RYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAK 1288
Query: 463 XXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGY 522
LR + ++ Q+PVLF G++ N+ S + + EE+ E+A+ DF+S LP+
Sbjct: 1289 IGLHDLRFKITIIPQDPVLFSGSLRMNLDPFS-QYSDEEVWTSLELAHLKDFVSALPDKL 1347
Query: 523 DTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGR 582
D E G +LS GQ+Q + +AR+LLR+ +L+LDEAT+A+D ++ +Q+ +
Sbjct: 1348 DHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDC 1407
Query: 583 TTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKL 627
T +T++HRL+TI++ R+I +D+G I E G DL++ +G ++ +
Sbjct: 1408 TVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSM 1452
Score = 58.8 bits (136), Expect = 1e-07
Identities = 89/435 (20%), Positives = 179/435 (41%), Gaps = 30/435 (6%)
Query: 102 IDDAKAMAI-GMFISIGVSLVFCVLSFSLISWSALRQIT--RIRTLFLRSVLRQDMSWYD 158
++D KA G F ++ + + C+ + L + + ++ RI+T + +V R+ + +
Sbjct: 337 VNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITN 396
Query: 159 TDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPLGW----QLTLACAA 214
+ + + ++ NLMS+ LA N++ ++ + + A L W LA A
Sbjct: 397 SARKSSTVGEIV-NLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVA 455
Query: 215 VMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAFGGENKEVERYRRL 274
VM V + ++ + M+S K EIL ++ + + E ++ +
Sbjct: 456 VMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAI 515
Query: 275 LEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVY 334
+ + +K + +G F WV T L A+ ++ + +++ +N+ V
Sbjct: 516 RQEELKVLKKSAYLSAVGT-FTWVCTPFLVAL-CTFAVYVTIDE----NNILDAQTAFVS 569
Query: 335 SILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPRRVVGDI 394
LF++ +I V IF L E + DS++++ + I
Sbjct: 570 LALFNILRFPLNILPMVISSIVQASVSLKRLRIF-LSHEELEPDSIERRPVKDGGGTNSI 628
Query: 395 LLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVX 454
+ + F + +R + L G + + G VA+VG GCGKS++L L D G V
Sbjct: 629 TVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVA 687
Query: 455 XXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDF 514
++ S+ V Q+ + ++ +NI G + + V +
Sbjct: 688 -------------IKGSVAYVPQQAWIQNDSLRENILFGC-QLEEPYYRSVIQACALLPD 733
Query: 515 ISLLPNGYDTVIGER 529
+ +LP+G T IGE+
Sbjct: 734 LEILPSGDRTEIGEK 748
Score = 57.6 bits (133), Expect = 3e-07
Identities = 89/423 (21%), Positives = 165/423 (39%), Gaps = 29/423 (6%)
Query: 834 KETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFL 893
++++TVG I +S D I +I V++ L L +
Sbjct: 399 RKSSTVGEIVNLMSVDAQRFMDLATY-INMIWSAPLQVILALYLLWLNLGPSVLAGVAVM 457
Query: 894 PLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALK 953
LMV + + ++ Q+ + ++ + E + IK ++ E F K A++
Sbjct: 458 VLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVL-AIR 516
Query: 954 TACVAVAYKTRWRGLVYGLG-VYIPFM-AYCSATVYGAVLVAYGEMEYKLVLLVNEAIM- 1010
+ V K+ + V V PF+ A C+ VY V + + V+ A+
Sbjct: 517 QEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVY--VTIDENNILDAQTAFVSLALFN 574
Query: 1011 YGAYMLGQSLVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVE 1070
+ L + S+ A R+ + + +++ + KD + + ++R+
Sbjct: 575 ILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNAT 634
Query: 1071 FCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDI 1130
F + R L GI + G +A+VG GCGKS++L D G +
Sbjct: 635 FTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHV------- 686
Query: 1131 RSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVS 1190
++ + V Q+ + + SL ENI +G + ++ A + S
Sbjct: 687 -------AIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPS 739
Query: 1191 LPKAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWR 1250
+ TE EK T I + H +S + D+I V+ GKI E G++ EL++ G +
Sbjct: 740 GDR--TEIGEK-----TRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAE 792
Query: 1251 MCR 1253
R
Sbjct: 793 FLR 795
Score = 48.8 bits (111), Expect = 1e-04
Identities = 35/136 (25%), Positives = 68/136 (50%), Gaps = 7/136 (5%)
Query: 1058 WVASGNFSMRDVEFCYPTRPS-QRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFY 1116
W G R+ +C R VL+ I++ + G+ + +VG +G GKS++ R
Sbjct: 1215 WPQVGRVEFRN--YCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRIN 1272
Query: 1117 DPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIV 1176
+ G I +D +I + + + LR ++ ++ Q+PVL SL N+ D + + E+
Sbjct: 1273 ESAEGEIIIDGINI-AKIGLHDLRFKITIIPQDPVLFSGSLRMNL---DPFSQYSDEEVW 1328
Query: 1177 AAAKAANIHSFIVSLP 1192
+ + A++ F+ +LP
Sbjct: 1329 TSLELAHLKDFVSALP 1344
Score = 46.4 bits (105), Expect = 6e-04
Identities = 37/143 (25%), Positives = 67/143 (46%), Gaps = 18/143 (12%)
Query: 1122 FIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKA 1181
F + + ++ ++L + L+ V P LD AE G N V ++V A+A
Sbjct: 1319 FSQYSDEEVWTSLELAHLK---DFVSALPDKLDHECAE----GGENLSVGQRQLVCLARA 1371
Query: 1182 ANIHSFIVSLPKA-----------VTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKG 1230
+ I+ L +A + + + T +TIAHRL+T+ D + V+DKG
Sbjct: 1372 LLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKG 1431
Query: 1231 KIVERGTHAELVSMKGHYWRMCR 1253
+I E G ++L+ +G ++ M +
Sbjct: 1432 EIQEYGAPSDLLQQRGLFYSMAK 1454
Score = 40.7 bits (91), Expect = 0.032
Identities = 21/67 (31%), Positives = 36/67 (53%), Gaps = 1/67 (1%)
Query: 576 DRASVG-RTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNEN 634
DR +G +T I V+H +S + D II M G I E G++++L+ G + + + T
Sbjct: 741 DRTEIGEKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYAST 800
Query: 635 KEPADIE 641
++ D E
Sbjct: 801 EQEQDAE 807
>AF022853-1|AAB83979.1| 1515|Homo sapiens multidrug resistance protein
protein.
Length = 1515
Score = 142 bits (344), Expect = 7e-33
Identities = 131/525 (24%), Positives = 243/525 (46%), Gaps = 23/525 (4%)
Query: 110 IGMFISIGVSLVFCVLSFSL-ISWSALRQITRIRTLFLRSVLRQDMSWYDTDSEFNLASK 168
+ ++ ++G+S V +S+ +S + + L S+LR MS+++ NL ++
Sbjct: 1000 LSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNR 1059
Query: 169 MSENLMSIKEGMGEKLAVVSNLVGT--SVICLCTAFPLGWQLTLACAAVMPFSVITSIAL 226
S+ L ++ + E V+ +G+ +VI C L +A + P +I
Sbjct: 1060 FSKELDTVDSMIPE---VIKMFMGSLFNVIGACIVILLA--TPIAAIIIPPLGLIYFFVQ 1114
Query: 227 SNYQTKS-SIREMESYSLAGKQAE--EILKSVRTIVAFGGENKEVERYRRLLEPAEEFGR 283
Y S ++ +ES S + + E L V I AF +E ER+ + + +
Sbjct: 1115 RFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAF----EEQERFIHQSDLKVDENQ 1170
Query: 284 KRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVYSILFSVYMA 343
K + + N W L L +G + + +L VG S+ +S+ +
Sbjct: 1171 KAYYPSIVAN--RW-LAVRLECVGNCIVLFAALFAVISRHSLSAGLVGL--SVSYSLQVT 1225
Query: 344 TQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPRRVVGDILLEDVEFCY 403
T + + V + E E + Q+ P +E +C
Sbjct: 1226 TY-LNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCL 1284
Query: 404 PSRPEVK-VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXX 462
R ++ VL+ ++ + GE V +VG +G GKS++ L R+ + G +
Sbjct: 1285 RYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAK 1344
Query: 463 XXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGY 522
LR + ++ Q+PVLF G++ N+ S + + EE+ E+A+ DF+S LP+
Sbjct: 1345 IGLHDLRFKITIIPQDPVLFSGSLRMNLDPFS-QYSDEEVWTSLELAHLKDFVSALPDKL 1403
Query: 523 DTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGR 582
D E G +LS GQ+Q + +AR+LLR+ +L+LDEAT+A+D ++ +Q+ +
Sbjct: 1404 DHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDC 1463
Query: 583 TTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKL 627
T +T++HRL+TI++ R+I +D+G I E G DL++ +G ++ +
Sbjct: 1464 TVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSM 1508
Score = 119 bits (287), Expect = 6e-26
Identities = 124/550 (22%), Positives = 242/550 (44%), Gaps = 33/550 (6%)
Query: 102 IDDAKAMAI-GMFISIGVSLVFCVLSFSLISWSALRQIT--RIRTLFLRSVLRQDMSWYD 158
++D KA G F ++ + + C+ + L + + ++ RI+T + +V R+ + +
Sbjct: 337 VNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITN 396
Query: 159 TDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPLGW----QLTLACAA 214
+ + + ++ NLMS+ LA N++ ++ + + A L W LA A
Sbjct: 397 SARKSSTVGEIV-NLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVA 455
Query: 215 VMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAFGGENKEVERYRRL 274
VM V + ++ + M+S K EIL ++ + + E ++ +
Sbjct: 456 VMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAI 515
Query: 275 LEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVY 334
+ + +K + +G F WV T L A+ ++ + +++ +N+ V
Sbjct: 516 RQEELKVLKKSAYLSAVGT-FTWVCTPFLVAL-CTFAVYVTIDE----NNILDAQTAFVS 569
Query: 335 SILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPRRVVGDI 394
LF++ +I V IF L E + DS++++ + I
Sbjct: 570 LALFNILRFPLNILPMVISSIVQASVSLKRLRIF-LSHEELEPDSIERRPVKDGGGTNSI 628
Query: 395 LLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVX 454
+ + F + +R + L G + + G VA+VG GCGKS++L L D G V
Sbjct: 629 TVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVA 687
Query: 455 XXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDF 514
++ S+ V Q+ + ++ +NI G + + V +
Sbjct: 688 -------------IKGSVAYVPQQAWIQNDSLRENILFGC-QLEEPYYRSVIQACALLPD 733
Query: 515 ISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QA 573
+ +LP+G T IGE+G +LSGGQKQR+++AR++ + L D+ SA+D H + + +
Sbjct: 734 LEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFEN 793
Query: 574 ALDRASV--GRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTG 631
+ + +T I V+H +S + D II M G I E G++++L+ G + + + T
Sbjct: 794 VIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTY 853
Query: 632 NENKEPADIE 641
++ D E
Sbjct: 854 ASTEQEQDAE 863
Score = 48.8 bits (111), Expect = 1e-04
Identities = 35/136 (25%), Positives = 68/136 (50%), Gaps = 7/136 (5%)
Query: 1058 WVASGNFSMRDVEFCYPTRPS-QRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFY 1116
W G R+ +C R VL+ I++ + G+ + +VG +G GKS++ R
Sbjct: 1271 WPQVGRVEFRN--YCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRIN 1328
Query: 1117 DPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIV 1176
+ G I +D +I + + + LR ++ ++ Q+PVL SL N+ D + + E+
Sbjct: 1329 ESAEGEIIIDGINI-AKIGLHDLRFKITIIPQDPVLFSGSLRMNL---DPFSQYSDEEVW 1384
Query: 1177 AAAKAANIHSFIVSLP 1192
+ + A++ F+ +LP
Sbjct: 1385 TSLELAHLKDFVSALP 1400
Score = 46.4 bits (105), Expect = 6e-04
Identities = 37/143 (25%), Positives = 67/143 (46%), Gaps = 18/143 (12%)
Query: 1122 FIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKA 1181
F + + ++ ++L + L+ V P LD AE G N V ++V A+A
Sbjct: 1375 FSQYSDEEVWTSLELAHLK---DFVSALPDKLDHECAE----GGENLSVGQRQLVCLARA 1427
Query: 1182 ANIHSFIVSLPKA-----------VTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKG 1230
+ I+ L +A + + + T +TIAHRL+T+ D + V+DKG
Sbjct: 1428 LLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKG 1487
Query: 1231 KIVERGTHAELVSMKGHYWRMCR 1253
+I E G ++L+ +G ++ M +
Sbjct: 1488 EIQEYGAPSDLLQQRGLFYSMAK 1510
Score = 39.9 bits (89), Expect = 0.056
Identities = 59/295 (20%), Positives = 114/295 (38%), Gaps = 8/295 (2%)
Query: 834 KETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFL 893
++++TVG I +S D I +I V++ L L +
Sbjct: 399 RKSSTVGEIVNLMSVDAQRFMDLATY-INMIWSAPLQVILALYLLWLNLGPSVLAGVAVM 457
Query: 894 PLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALK 953
LMV + + ++ Q+ + ++ + E + IK ++ E F K A++
Sbjct: 458 VLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVL-AIR 516
Query: 954 TACVAVAYKTRWRGLVYGLG-VYIPFM-AYCSATVYGAVLVAYGEMEYKLVLLVNEAIM- 1010
+ V K+ + V V PF+ A C+ VY V + + V+ A+
Sbjct: 517 QEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVY--VTIDENNILDAQTAFVSLALFN 574
Query: 1011 YGAYMLGQSLVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVE 1070
+ L + S+ A R+ + + +++ + KD + + ++R+
Sbjct: 575 ILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNAT 634
Query: 1071 FCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIEL 1125
F + R L GI + G +A+VG GCGKS++L D G + +
Sbjct: 635 FTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAI 688
Score = 36.7 bits (81), Expect = 0.53
Identities = 17/50 (34%), Positives = 28/50 (56%)
Query: 1204 KGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRMCR 1253
K +T I + H +S + D+I V+ GKI E G++ EL++ G + R
Sbjct: 802 KNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLR 851
>AB209120-1|BAD92357.1| 1439|Homo sapiens ATP-binding cassette,
sub-family C, member 1 isoform 1 variant protein.
Length = 1439
Score = 142 bits (344), Expect = 7e-33
Identities = 131/525 (24%), Positives = 243/525 (46%), Gaps = 23/525 (4%)
Query: 110 IGMFISIGVSLVFCVLSFSL-ISWSALRQITRIRTLFLRSVLRQDMSWYDTDSEFNLASK 168
+ ++ ++G+S V +S+ +S + + L S+LR MS+++ NL ++
Sbjct: 924 LSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNR 983
Query: 169 MSENLMSIKEGMGEKLAVVSNLVGT--SVICLCTAFPLGWQLTLACAAVMPFSVITSIAL 226
S+ L ++ + E V+ +G+ +VI C L +A + P +I
Sbjct: 984 FSKELDTVDSMIPE---VIKMFMGSLFNVIGACIVILLA--TPIAAIIIPPLGLIYFFVQ 1038
Query: 227 SNYQTKS-SIREMESYSLAGKQAE--EILKSVRTIVAFGGENKEVERYRRLLEPAEEFGR 283
Y S ++ +ES S + + E L V I AF +E ER+ + + +
Sbjct: 1039 RFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAF----EEQERFIHQSDLKVDENQ 1094
Query: 284 KRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVYSILFSVYMA 343
K + + N W L L +G + + +L VG S+ +S+ +
Sbjct: 1095 KAYYPSIVAN--RW-LAVRLECVGNCIVLFAALFAVISRHSLSAGLVGL--SVSYSLQVT 1149
Query: 344 TQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPRRVVGDILLEDVEFCY 403
T + + V + E E + Q+ P +E +C
Sbjct: 1150 TY-LNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCL 1208
Query: 404 PSRPEVK-VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXX 462
R ++ VL+ ++ + GE V +VG +G GKS++ L R+ + G +
Sbjct: 1209 RYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAK 1268
Query: 463 XXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGY 522
LR + ++ Q+PVLF G++ N+ S + + EE+ E+A+ DF+S LP+
Sbjct: 1269 IGLHDLRFKITIIPQDPVLFSGSLRMNLDPFS-QYSDEEVWTSLELAHLKDFVSALPDKL 1327
Query: 523 DTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGR 582
D E G +LS GQ+Q + +AR+LLR+ +L+LDEAT+A+D ++ +Q+ +
Sbjct: 1328 DHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDC 1387
Query: 583 TTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKL 627
T +T++HRL+TI++ R+I +D+G I E G DL++ +G ++ +
Sbjct: 1388 TVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSM 1432
Score = 119 bits (287), Expect = 6e-26
Identities = 124/550 (22%), Positives = 242/550 (44%), Gaps = 33/550 (6%)
Query: 102 IDDAKAMAI-GMFISIGVSLVFCVLSFSLISWSALRQIT--RIRTLFLRSVLRQDMSWYD 158
++D KA G F ++ + + C+ + L + + ++ RI+T + +V R+ + +
Sbjct: 251 VNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITN 310
Query: 159 TDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPLGW----QLTLACAA 214
+ + + ++ NLMS+ LA N++ ++ + + A L W LA A
Sbjct: 311 SARKSSTVGEIV-NLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVA 369
Query: 215 VMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAFGGENKEVERYRRL 274
VM V + ++ + M+S K EIL ++ + + E ++ +
Sbjct: 370 VMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAI 429
Query: 275 LEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVY 334
+ + +K + +G F WV T L A+ ++ + +++ +N+ V
Sbjct: 430 RQEELKVLKKSAYLSAVGT-FTWVCTPFLVAL-CTFAVYVTIDE----NNILDAQTAFVS 483
Query: 335 SILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPRRVVGDI 394
LF++ +I V IF L E + DS++++ + I
Sbjct: 484 LALFNILRFPLNILPMVISSIVQASVSLKRLRIF-LSHEELEPDSIERRPVKDGGGTNSI 542
Query: 395 LLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVX 454
+ + F + +R + L G + + G VA+VG GCGKS++L L D G V
Sbjct: 543 TVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVA 601
Query: 455 XXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDF 514
++ S+ V Q+ + ++ +NI G + + V +
Sbjct: 602 -------------IKGSVAYVPQQAWIQNDSLRENILFGC-QLEEPYYRSVIQACALLPD 647
Query: 515 ISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QA 573
+ +LP+G T IGE+G +LSGGQKQR+++AR++ + L D+ SA+D H + + +
Sbjct: 648 LEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFEN 707
Query: 574 ALDRASV--GRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTG 631
+ + +T I V+H +S + D II M G I E G++++L+ G + + + T
Sbjct: 708 VIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTY 767
Query: 632 NENKEPADIE 641
++ D E
Sbjct: 768 ASTEQEQDAE 777
Score = 48.8 bits (111), Expect = 1e-04
Identities = 35/136 (25%), Positives = 68/136 (50%), Gaps = 7/136 (5%)
Query: 1058 WVASGNFSMRDVEFCYPTRPS-QRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFY 1116
W G R+ +C R VL+ I++ + G+ + +VG +G GKS++ R
Sbjct: 1195 WPQVGRVEFRN--YCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRIN 1252
Query: 1117 DPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIV 1176
+ G I +D +I + + + LR ++ ++ Q+PVL SL N+ D + + E+
Sbjct: 1253 ESAEGEIIIDGINI-AKIGLHDLRFKITIIPQDPVLFSGSLRMNL---DPFSQYSDEEVW 1308
Query: 1177 AAAKAANIHSFIVSLP 1192
+ + A++ F+ +LP
Sbjct: 1309 TSLELAHLKDFVSALP 1324
Score = 46.4 bits (105), Expect = 6e-04
Identities = 37/143 (25%), Positives = 67/143 (46%), Gaps = 18/143 (12%)
Query: 1122 FIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKA 1181
F + + ++ ++L + L+ V P LD AE G N V ++V A+A
Sbjct: 1299 FSQYSDEEVWTSLELAHLK---DFVSALPDKLDHECAE----GGENLSVGQRQLVCLARA 1351
Query: 1182 ANIHSFIVSLPKA-----------VTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKG 1230
+ I+ L +A + + + T +TIAHRL+T+ D + V+DKG
Sbjct: 1352 LLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKG 1411
Query: 1231 KIVERGTHAELVSMKGHYWRMCR 1253
+I E G ++L+ +G ++ M +
Sbjct: 1412 EIQEYGAPSDLLQQRGLFYSMAK 1434
Score = 39.9 bits (89), Expect = 0.056
Identities = 59/295 (20%), Positives = 114/295 (38%), Gaps = 8/295 (2%)
Query: 834 KETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFL 893
++++TVG I +S D I +I V++ L L +
Sbjct: 313 RKSSTVGEIVNLMSVDAQRFMDLATY-INMIWSAPLQVILALYLLWLNLGPSVLAGVAVM 371
Query: 894 PLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALK 953
LMV + + ++ Q+ + ++ + E + IK ++ E F K A++
Sbjct: 372 VLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVL-AIR 430
Query: 954 TACVAVAYKTRWRGLVYGLG-VYIPFM-AYCSATVYGAVLVAYGEMEYKLVLLVNEAIM- 1010
+ V K+ + V V PF+ A C+ VY V + + V+ A+
Sbjct: 431 QEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVY--VTIDENNILDAQTAFVSLALFN 488
Query: 1011 YGAYMLGQSLVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVE 1070
+ L + S+ A R+ + + +++ + KD + + ++R+
Sbjct: 489 ILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNAT 548
Query: 1071 FCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIEL 1125
F + R L GI + G +A+VG GCGKS++L D G + +
Sbjct: 549 FTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAI 602
Score = 36.7 bits (81), Expect = 0.53
Identities = 17/50 (34%), Positives = 28/50 (56%)
Query: 1204 KGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRMCR 1253
K +T I + H +S + D+I V+ GKI E G++ EL++ G + R
Sbjct: 716 KNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLR 765
>U49248-1|AAB09422.1| 1545|Homo sapiens canalicular multispecific
organic anion transporter protein.
Length = 1545
Score = 142 bits (343), Expect = 9e-33
Identities = 130/542 (23%), Positives = 258/542 (47%), Gaps = 39/542 (7%)
Query: 108 MAIGMFISIGVSL-VFCVLSFSLISWSALRQITRIRTLFLRSVLRQDMSWYDTDSEFNLA 166
M +G++ ++G++ +F ++ ++ + + L ++LR M ++DT +
Sbjct: 1022 MRVGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRIV 1081
Query: 167 SKMSENLMSIKEGMGEKL-AVVSNLVG--TSVICLCTAFPLGWQLTLACAAVMPFSVI-T 222
++ + ++ ++ + + + L + ++ +G ++++ +C A P+ T+ V+P +I
Sbjct: 1082 NRFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPV---FTII---VIPLGIIYV 1135
Query: 223 SIALSNYQTKSSIREMESYSLAG--KQAEEILKSVRTIVAFGGENKEVERYRRLLEPAEE 280
S+ + T +R ++S + + E + + I AF E +R L+ EE
Sbjct: 1136 SVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAF-------EHQQRFLKHNEE 1188
Query: 281 F--GRKRGLFTGLGNGFNWVLTYSLNAIG---FSYGTRLVVNDFDTDSNLRQYPVGAVYS 335
++ +F+ + + W L L +G + ++V DT L VG V S
Sbjct: 1189 RIDTNQKCVFSWITSN-RW-LAIRLELVGNLTVFFSALMMVIYRDT---LSGDTVGFVLS 1243
Query: 336 ILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPR-RVVGDI 394
++ TQ++ + V I + E + + K P G I
Sbjct: 1244 NALNI---TQTLNWLVRMTSEIETNIVAVERITEYTKVENEAPWVTDKRPPPDWPSKGKI 1300
Query: 395 LLEDVEFCYPSRPEVK-VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSV 453
+ + Y RPE+ VL+G + + E + +VG +G GKS++ L R+ + G +
Sbjct: 1301 QFNNYQVRY--RPELDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQI 1358
Query: 454 XXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHD 513
LR L ++ Q+P+LF G++ N+ + + EEI + E+A+
Sbjct: 1359 IIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLDPFN-NYSDEEIWKALELAHLKS 1417
Query: 514 FISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQA 573
F++ L G + E G +LS GQ+Q + + R+LLR+ +L+LDEAT+A+D ++ +Q
Sbjct: 1418 FVASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQT 1477
Query: 574 ALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKG-FYHKLVTTGN 632
+ T IT++HRL TI+++D+++ +D G I+E G+ E+L++ G FY G
Sbjct: 1478 TIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIEYGSPEELLQIPGPFYFMAKEAGI 1537
Query: 633 EN 634
EN
Sbjct: 1538 EN 1539
Score = 139 bits (337), Expect = 5e-32
Identities = 186/818 (22%), Positives = 342/818 (41%), Gaps = 65/818 (7%)
Query: 412 LKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSS 471
++ ++ + G+ VA++G G GKS+++ + + G + SW+++
Sbjct: 654 VRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTTAYVPQQSWIQN- 712
Query: 472 LGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGA 531
GTI DNI G+ E + Q+V E + +LP G IGE+G
Sbjct: 713 ------------GTIKDNILFGT-EFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGI 759
Query: 532 SLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASV--GRTTITVS 588
+LSGGQKQRI++AR+ + + LLD+ SA+D H + + L + G+T + V+
Sbjct: 760 NLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVT 819
Query: 589 HRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNEN---KEPADIEPLIE 645
H + + D I+ + G IVE+G++ L+ KG + K + T + +E A + E
Sbjct: 820 HSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLKTFLRHTGPEEEATVHDGSE 879
Query: 646 EADGDGDNIE-----PTVPSRLDVRRRSSKKVLRHHSIKKDHPDWLTPRGSISSMVSIGL 700
E D D I P + + +RR +S + S + + + R S+ + L
Sbjct: 880 EEDDDYGLISSVEEIPEDAASITMRRENSFRRTLSRSSRSNGRHLKSLRNSLKTRNVNSL 939
Query: 701 QNFVFNXXXXXXXXXXXXXTVKTVSDWQLLKLNAPEWPLITVGSIAAFLQGACFPVFAL- 759
+ T K L L A I +A + F L
Sbjct: 940 KEDEELVKGQKLIKKEFIETGKVKFSIYLEYLQAIGLFSIFFIILAFVMNSVAFIGSNLW 999
Query: 760 LFGFSSGIFILDNRDDIIYLADLYSVLFVVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQ 819
L ++S I ++ D D+ ++ + GI + + + + L Q
Sbjct: 1000 LSAWTSDSKIFNSTDYPASQRDMRVGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQ 1059
Query: 820 YFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAI 879
++L+ + FFD T G I R +GD + V + Q + S + FL I
Sbjct: 1060 LLNNILRAPMRFFD--TTPTGRIVNRFAGDISTVDDT-------LPQSLRSWITCFLGII 1110
Query: 880 SYNWKLTLVATVFLPLMV--GSIWLE---GIISQKAQIDERNAMESATAIA--TEAVVSI 932
S + + VF +++ G I++ +S Q+ +++ + + +E V +
Sbjct: 1111 STLVMICMATPVFTIIVIPLGIIYVSVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGL 1170
Query: 933 KTVQSLGVETVFLQKFQDALKT--ACV-AVAYKTRWRGLVYGLGVYIPFMAYCSATVYGA 989
+++ + FL+ ++ + T CV + RW L + + + +
Sbjct: 1171 PVIRAFEHQQRFLKHNEERIDTNQKCVFSWITSNRW------LAIRLELVGNLTVFFSAL 1224
Query: 990 VLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYAPSLNTAKACGARILSIIQRQPKIHN- 1048
++V Y + L ++ A + Q+L + + + + I K+ N
Sbjct: 1225 MMVIYRD---TLSGDTVGFVLSNALNITQTLNWLVRMTSEIETNIVAVERITEYTKVENE 1281
Query: 1049 AVGVKDKK---DWVASGNFSMRDVEFCYPTRPS-QRVLKGIDLKMEAGKTIALVGSSGCG 1104
A V DK+ DW + G + + Y RP VL+GI + + + I +VG +G G
Sbjct: 1282 APWVTDKRPPPDWPSKGKIQFNNYQVRY--RPELDLVLRGITCDIGSMEKIGVVGRTGAG 1339
Query: 1105 KSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYG 1164
KS++ R + G I +D DI S + + LR +L ++ Q+P+L SL N+
Sbjct: 1340 KSSLTNCLFRILEAAGGQIIIDGVDIAS-IGLHDLREKLTIIPQDPILFSGSLRMNL--- 1395
Query: 1165 DNNRKVTMHEIVAAAKAANIHSFIVSLPKAVTEALEKA 1202
D + EI A + A++ SF+ SL ++ + +A
Sbjct: 1396 DPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEA 1433
Score = 51.2 bits (117), Expect = 2e-05
Identities = 22/47 (46%), Positives = 33/47 (70%)
Query: 1207 TCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRMCR 1253
T ITIAHRL T+ D+D + V+D GKI+E G+ EL+ + G ++ M +
Sbjct: 1487 TVITIAHRLHTIMDSDKVMVLDNGKIIEYGSPEELLQIPGPFYFMAK 1533
Score = 37.9 bits (84), Expect = 0.23
Identities = 15/45 (33%), Positives = 28/45 (62%)
Query: 1204 KGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHY 1248
KG+T + + H + + D I V+ G IVE+G+++ L++ KG +
Sbjct: 811 KGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEF 855
>X96395-1|CAA65259.2| 1545|Homo sapiens canalicular multidrug
resistance protein protein.
Length = 1545
Score = 140 bits (338), Expect = 4e-32
Identities = 128/540 (23%), Positives = 258/540 (47%), Gaps = 35/540 (6%)
Query: 108 MAIGMFISIGVSL-VFCVLSFSLISWSALRQITRIRTLFLRSVLRQDMSWYDTDSEFNLA 166
M +G++ ++G++ +F ++ ++ + + L ++LR M ++DT +
Sbjct: 1022 MRVGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRIV 1081
Query: 167 SKMSENLMSIKEGMGEKL-AVVSNLVG--TSVICLCTAFPLGWQLTLACAAVMPFSVI-T 222
++ + ++ ++ + + + L + ++ +G ++++ +C A P+ T+ V+P +I
Sbjct: 1082 NRFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPV---FTII---VIPLGIIYV 1135
Query: 223 SIALSNYQTKSSIREMESYSLAG--KQAEEILKSVRTIVAFGGENKEVERYRRLLEPAEE 280
S+ + T +R ++S + + E + + I AF + +R+ + E +
Sbjct: 1136 SVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAF----EHQQRFLKHNEVRID 1191
Query: 281 FGRKRGLFTGLGNGFNWVLTYSLNAIG---FSYGTRLVVNDFDTDSNLRQYPVGAVYSIL 337
+K +F+ + + W L L +G + ++V DT L VG V S
Sbjct: 1192 TNQKC-VFSWITSN-RW-LAIRLELVGNLTVFFSALMMVIYRDT---LSGDTVGFVLSNA 1245
Query: 338 FSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPR-RVVGDILL 396
++ TQ++ + V I + E + + K P G I
Sbjct: 1246 LNI---TQTLNWLVRMTSEIETNIVAVERITEYTKVENEAPWVTDKRPPPDWPSKGKIQF 1302
Query: 397 EDVEFCYPSRPEVK-VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXX 455
+ + Y RPE+ VL+G + + E + +VG +G GKS++ L R+ + G +
Sbjct: 1303 NNYQVRY--RPELDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIII 1360
Query: 456 XXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFI 515
LR L ++ Q+P+LF G++ N+ + + EEI + E+A+ F+
Sbjct: 1361 DGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLDPFN-NYSDEEIWKALELAHLKSFV 1419
Query: 516 SLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAAL 575
+ L G + E G +LS GQ+Q + + R+LLR+ +L+LDEAT+A+D ++ +Q +
Sbjct: 1420 ASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTI 1479
Query: 576 DRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKG-FYHKLVTTGNEN 634
T IT++HRL TI+++D+++ +D G I+E G+ E+L++ G FY G EN
Sbjct: 1480 QNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGPFYFMAKEAGIEN 1539
Score = 137 bits (332), Expect = 2e-31
Identities = 186/818 (22%), Positives = 341/818 (41%), Gaps = 65/818 (7%)
Query: 412 LKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSS 471
++ ++ + G+ VA++G G GKS+++ + + G + SW+++
Sbjct: 654 VRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTTAYVPQQSWIQN- 712
Query: 472 LGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGA 531
GTI DNI G+ E + Q+V E + +LP G IGE+G
Sbjct: 713 ------------GTIKDNILFGT-EFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGI 759
Query: 532 SLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASV--GRTTITVS 588
+LSGGQKQRI++AR+ + + LLD+ SA+D H + + L + G+T + V+
Sbjct: 760 NLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVT 819
Query: 589 HRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNEN---KEPADIEPLIE 645
H + + D I+ + G IVE+G++ L+ KG + K + T + +E A + E
Sbjct: 820 HSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLKTFLRHTGPEEEATVHDGSE 879
Query: 646 EADGDGDNIE-----PTVPSRLDVRRRSSKKVLRHHSIKKDHPDWLTPRGSISSMVSIGL 700
E D D I P + + +RR +S + S + + + R S+ + L
Sbjct: 880 EEDDDYGLISSVEEIPEDAASITMRRENSFRRTLSRSSRSNGRHLKSLRNSLKTRNVNSL 939
Query: 701 QNFVFNXXXXXXXXXXXXXTVKTVSDWQLLKLNAPEWPLITVGSIAAFLQGACFPVFAL- 759
+ T K L L A I +A + F L
Sbjct: 940 KEDEELVKGQKLIKKEFIETGKVKFSIYLEYLQAIGLFSIFFIILAFVMNSVAFIGSNLW 999
Query: 760 LFGFSSGIFILDNRDDIIYLADLYSVLFVVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQ 819
L ++S I ++ D D+ ++ + GI + + + + L Q
Sbjct: 1000 LSAWTSDSKIFNSTDYPASQRDMRVGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQ 1059
Query: 820 YFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAI 879
++L+ + FFD T G I R +GD + V + Q + S + FL I
Sbjct: 1060 LLNNILRAPMRFFD--TTPTGRIVNRFAGDISTVDDT-------LPQSLRSWITCFLGII 1110
Query: 880 SYNWKLTLVATVFLPLMV--GSIWLE---GIISQKAQIDERNAMESATAIA--TEAVVSI 932
S + + VF +++ G I++ +S Q+ +++ + + +E V +
Sbjct: 1111 STLVMICMATPVFTIIVIPLGIIYVSVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGL 1170
Query: 933 KTVQSLGVETVFLQKFQDALKT--ACV-AVAYKTRWRGLVYGLGVYIPFMAYCSATVYGA 989
+++ + FL+ + + T CV + RW L + + + +
Sbjct: 1171 PVIRAFEHQQRFLKHNEVRIDTNQKCVFSWITSNRW------LAIRLELVGNLTVFFSAL 1224
Query: 990 VLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYAPSLNTAKACGARILSIIQRQPKIHN- 1048
++V Y + L ++ A + Q+L + + + + I K+ N
Sbjct: 1225 MMVIYRD---TLSGDTVGFVLSNALNITQTLNWLVRMTSEIETNIVAVERITEYTKVENE 1281
Query: 1049 AVGVKDKK---DWVASGNFSMRDVEFCYPTRPS-QRVLKGIDLKMEAGKTIALVGSSGCG 1104
A V DK+ DW + G + + Y RP VL+GI + + + I +VG +G G
Sbjct: 1282 APWVTDKRPPPDWPSKGKIQFNNYQVRY--RPELDLVLRGITCDIGSMEKIGVVGRTGAG 1339
Query: 1105 KSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYG 1164
KS++ R + G I +D DI S + + LR +L ++ Q+P+L SL N+
Sbjct: 1340 KSSLTNCLFRILEAAGGQIIIDGVDIAS-IGLHDLREKLTIIPQDPILFSGSLRMNL--- 1395
Query: 1165 DNNRKVTMHEIVAAAKAANIHSFIVSLPKAVTEALEKA 1202
D + EI A + A++ SF+ SL ++ + +A
Sbjct: 1396 DPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEA 1433
Score = 50.8 bits (116), Expect = 3e-05
Identities = 22/47 (46%), Positives = 33/47 (70%)
Query: 1207 TCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRMCR 1253
T ITIAHRL T+ D+D + V+D GKI+E G+ EL+ + G ++ M +
Sbjct: 1487 TVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGPFYFMAK 1533
Score = 37.9 bits (84), Expect = 0.23
Identities = 15/45 (33%), Positives = 28/45 (62%)
Query: 1204 KGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHY 1248
KG+T + + H + + D I V+ G IVE+G+++ L++ KG +
Sbjct: 811 KGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEF 855
>U63970-1|AAB39892.1| 1545|Homo sapiens canalicular multispecific
organic anion transporter protein.
Length = 1545
Score = 140 bits (338), Expect = 4e-32
Identities = 128/540 (23%), Positives = 258/540 (47%), Gaps = 35/540 (6%)
Query: 108 MAIGMFISIGVSL-VFCVLSFSLISWSALRQITRIRTLFLRSVLRQDMSWYDTDSEFNLA 166
M +G++ ++G++ +F ++ ++ + + L ++LR M ++DT +
Sbjct: 1022 MRVGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRIV 1081
Query: 167 SKMSENLMSIKEGMGEKL-AVVSNLVG--TSVICLCTAFPLGWQLTLACAAVMPFSVI-T 222
++ + ++ ++ + + + L + ++ +G ++++ +C A P+ T+ V+P +I
Sbjct: 1082 NRFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPV---FTII---VIPLGIIYV 1135
Query: 223 SIALSNYQTKSSIREMESYSLAG--KQAEEILKSVRTIVAFGGENKEVERYRRLLEPAEE 280
S+ + T +R ++S + + E + + I AF + +R+ + E +
Sbjct: 1136 SVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAF----EHQQRFLKHNEVRID 1191
Query: 281 FGRKRGLFTGLGNGFNWVLTYSLNAIG---FSYGTRLVVNDFDTDSNLRQYPVGAVYSIL 337
+K +F+ + + W L L +G + ++V DT L VG V S
Sbjct: 1192 TNQKC-VFSWITSN-RW-LAIRLELVGNLTVFFSALMMVIYRDT---LSGDTVGFVLSNA 1245
Query: 338 FSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPR-RVVGDILL 396
++ TQ++ + V I + E + + K P G I
Sbjct: 1246 LNI---TQTLNWLVRMTSEIETNIVAVERITEYTKVENEAPWVTDKRPPPDWPSKGKIQF 1302
Query: 397 EDVEFCYPSRPEVK-VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXX 455
+ + Y RPE+ VL+G + + E + +VG +G GKS++ L R+ + G +
Sbjct: 1303 NNYQVRY--RPELDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIII 1360
Query: 456 XXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFI 515
LR L ++ Q+P+LF G++ N+ + + EEI + E+A+ F+
Sbjct: 1361 DGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLDPFN-NYSDEEIWKALELAHLKSFV 1419
Query: 516 SLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAAL 575
+ L G + E G +LS GQ+Q + + R+LLR+ +L+LDEAT+A+D ++ +Q +
Sbjct: 1420 ASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTI 1479
Query: 576 DRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKG-FYHKLVTTGNEN 634
T IT++HRL TI+++D+++ +D G I+E G+ E+L++ G FY G EN
Sbjct: 1480 QNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGPFYFMAKEAGIEN 1539
Score = 137 bits (332), Expect = 2e-31
Identities = 186/818 (22%), Positives = 341/818 (41%), Gaps = 65/818 (7%)
Query: 412 LKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSS 471
++ ++ + G+ VA++G G GKS+++ + + G + SW+++
Sbjct: 654 VRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTTAYVPQQSWIQN- 712
Query: 472 LGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGA 531
GTI DNI G+ E + Q+V E + +LP G IGE+G
Sbjct: 713 ------------GTIKDNILFGT-EFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGI 759
Query: 532 SLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASV--GRTTITVS 588
+LSGGQKQRI++AR+ + + LLD+ SA+D H + + L + G+T + V+
Sbjct: 760 NLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVT 819
Query: 589 HRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNEN---KEPADIEPLIE 645
H + + D I+ + G IVE+G++ L+ KG + K + T + +E A + E
Sbjct: 820 HSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLKTFLRHTGPEEEATVHDGSE 879
Query: 646 EADGDGDNIE-----PTVPSRLDVRRRSSKKVLRHHSIKKDHPDWLTPRGSISSMVSIGL 700
E D D I P + + +RR +S + S + + + R S+ + L
Sbjct: 880 EEDDDYGLISSVEEIPEDAASITMRRENSFRRTLSRSSRSNGRHLKSLRNSLKTRNVNSL 939
Query: 701 QNFVFNXXXXXXXXXXXXXTVKTVSDWQLLKLNAPEWPLITVGSIAAFLQGACFPVFAL- 759
+ T K L L A I +A + F L
Sbjct: 940 KEDEELVKGQKLIKKEFIETGKVKFSIYLEYLQAIGLFSIFFIILAFVMNSVAFIGSNLW 999
Query: 760 LFGFSSGIFILDNRDDIIYLADLYSVLFVVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQ 819
L ++S I ++ D D+ ++ + GI + + + + L Q
Sbjct: 1000 LSAWTSDSKIFNSTDYPASQRDMRVGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQ 1059
Query: 820 YFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAI 879
++L+ + FFD T G I R +GD + V + Q + S + FL I
Sbjct: 1060 LLNNILRAPMRFFD--TTPTGRIVNRFAGDISTVDDT-------LPQSLRSWITCFLGII 1110
Query: 880 SYNWKLTLVATVFLPLMV--GSIWLE---GIISQKAQIDERNAMESATAIA--TEAVVSI 932
S + + VF +++ G I++ +S Q+ +++ + + +E V +
Sbjct: 1111 STLVMICMATPVFTIIVIPLGIIYVSVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGL 1170
Query: 933 KTVQSLGVETVFLQKFQDALKT--ACV-AVAYKTRWRGLVYGLGVYIPFMAYCSATVYGA 989
+++ + FL+ + + T CV + RW L + + + +
Sbjct: 1171 PVIRAFEHQQRFLKHNEVRIDTNQKCVFSWITSNRW------LAIRLELVGNLTVFFSAL 1224
Query: 990 VLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYAPSLNTAKACGARILSIIQRQPKIHN- 1048
++V Y + L ++ A + Q+L + + + + I K+ N
Sbjct: 1225 MMVIYRD---TLSGDTVGFVLSNALNITQTLNWLVRMTSEIETNIVAVERITEYTKVENE 1281
Query: 1049 AVGVKDKK---DWVASGNFSMRDVEFCYPTRPS-QRVLKGIDLKMEAGKTIALVGSSGCG 1104
A V DK+ DW + G + + Y RP VL+GI + + + I +VG +G G
Sbjct: 1282 APWVTDKRPPPDWPSKGKIQFNNYQVRY--RPELDLVLRGITCDIGSMEKIGVVGRTGAG 1339
Query: 1105 KSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYG 1164
KS++ R + G I +D DI S + + LR +L ++ Q+P+L SL N+
Sbjct: 1340 KSSLTNCLFRILEAAGGQIIIDGVDIAS-IGLHDLREKLTIIPQDPILFSGSLRMNL--- 1395
Query: 1165 DNNRKVTMHEIVAAAKAANIHSFIVSLPKAVTEALEKA 1202
D + EI A + A++ SF+ SL ++ + +A
Sbjct: 1396 DPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEA 1433
Score = 50.8 bits (116), Expect = 3e-05
Identities = 22/47 (46%), Positives = 33/47 (70%)
Query: 1207 TCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRMCR 1253
T ITIAHRL T+ D+D + V+D GKI+E G+ EL+ + G ++ M +
Sbjct: 1487 TVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGPFYFMAK 1533
Score = 37.9 bits (84), Expect = 0.23
Identities = 15/45 (33%), Positives = 28/45 (62%)
Query: 1204 KGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHY 1248
KG+T + + H + + D I V+ G IVE+G+++ L++ KG +
Sbjct: 811 KGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEF 855
>AL392107-3|CAI11010.1| 1545|Homo sapiens ATP-binding cassette,
sub-family C (CFTR/MRP), member 2 protein.
Length = 1545
Score = 140 bits (338), Expect = 4e-32
Identities = 128/540 (23%), Positives = 258/540 (47%), Gaps = 35/540 (6%)
Query: 108 MAIGMFISIGVSL-VFCVLSFSLISWSALRQITRIRTLFLRSVLRQDMSWYDTDSEFNLA 166
M +G++ ++G++ +F ++ ++ + + L ++LR M ++DT +
Sbjct: 1022 MRVGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRIV 1081
Query: 167 SKMSENLMSIKEGMGEKL-AVVSNLVG--TSVICLCTAFPLGWQLTLACAAVMPFSVI-T 222
++ + ++ ++ + + + L + ++ +G ++++ +C A P+ T+ V+P +I
Sbjct: 1082 NRFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPV---FTII---VIPLGIIYV 1135
Query: 223 SIALSNYQTKSSIREMESYSLAG--KQAEEILKSVRTIVAFGGENKEVERYRRLLEPAEE 280
S+ + T +R ++S + + E + + I AF + +R+ + E +
Sbjct: 1136 SVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAF----EHQQRFLKHNEVRID 1191
Query: 281 FGRKRGLFTGLGNGFNWVLTYSLNAIG---FSYGTRLVVNDFDTDSNLRQYPVGAVYSIL 337
+K +F+ + + W L L +G + ++V DT L VG V S
Sbjct: 1192 TNQKC-VFSWITSN-RW-LAIRLELVGNLTVFFSALMMVIYRDT---LSGDTVGFVLSNA 1245
Query: 338 FSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPR-RVVGDILL 396
++ TQ++ + V I + E + + K P G I
Sbjct: 1246 LNI---TQTLNWLVRMTSEIETNIVAVERITEYTKVENEAPWVTDKRPPPDWPSKGKIQF 1302
Query: 397 EDVEFCYPSRPEVK-VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXX 455
+ + Y RPE+ VL+G + + E + +VG +G GKS++ L R+ + G +
Sbjct: 1303 NNYQVRY--RPELDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIII 1360
Query: 456 XXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFI 515
LR L ++ Q+P+LF G++ N+ + + EEI + E+A+ F+
Sbjct: 1361 DGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLDPFN-NYSDEEIWKALELAHLKSFV 1419
Query: 516 SLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAAL 575
+ L G + E G +LS GQ+Q + + R+LLR+ +L+LDEAT+A+D ++ +Q +
Sbjct: 1420 ASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTI 1479
Query: 576 DRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKG-FYHKLVTTGNEN 634
T IT++HRL TI+++D+++ +D G I+E G+ E+L++ G FY G EN
Sbjct: 1480 QNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGPFYFMAKEAGIEN 1539
Score = 137 bits (332), Expect = 2e-31
Identities = 186/818 (22%), Positives = 341/818 (41%), Gaps = 65/818 (7%)
Query: 412 LKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSS 471
++ ++ + G+ VA++G G GKS+++ + + G + SW+++
Sbjct: 654 VRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTTAYVPQQSWIQN- 712
Query: 472 LGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGA 531
GTI DNI G+ E + Q+V E + +LP G IGE+G
Sbjct: 713 ------------GTIKDNILFGT-EFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGI 759
Query: 532 SLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASV--GRTTITVS 588
+LSGGQKQRI++AR+ + + LLD+ SA+D H + + L + G+T + V+
Sbjct: 760 NLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVT 819
Query: 589 HRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNEN---KEPADIEPLIE 645
H + + D I+ + G IVE+G++ L+ KG + K + T + +E A + E
Sbjct: 820 HSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLKTFLRHTGPEEEATVHDGSE 879
Query: 646 EADGDGDNIE-----PTVPSRLDVRRRSSKKVLRHHSIKKDHPDWLTPRGSISSMVSIGL 700
E D D I P + + +RR +S + S + + + R S+ + L
Sbjct: 880 EEDDDYGLISSVEEIPEDAASITMRRENSFRRTLSRSSRSNGRHLKSLRNSLKTRNVNSL 939
Query: 701 QNFVFNXXXXXXXXXXXXXTVKTVSDWQLLKLNAPEWPLITVGSIAAFLQGACFPVFAL- 759
+ T K L L A I +A + F L
Sbjct: 940 KEDEELVKGQKLIKKEFIETGKVKFSIYLEYLQAIGLFSIFFIILAFVMNSVAFIGSNLW 999
Query: 760 LFGFSSGIFILDNRDDIIYLADLYSVLFVVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQ 819
L ++S I ++ D D+ ++ + GI + + + + L Q
Sbjct: 1000 LSAWTSDSKIFNSTDYPASQRDMRVGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQ 1059
Query: 820 YFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAI 879
++L+ + FFD T G I R +GD + V + Q + S + FL I
Sbjct: 1060 LLNNILRAPMRFFD--TTPTGRIVNRFAGDISTVDDT-------LPQSLRSWITCFLGII 1110
Query: 880 SYNWKLTLVATVFLPLMV--GSIWLE---GIISQKAQIDERNAMESATAIA--TEAVVSI 932
S + + VF +++ G I++ +S Q+ +++ + + +E V +
Sbjct: 1111 STLVMICMATPVFTIIVIPLGIIYVSVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGL 1170
Query: 933 KTVQSLGVETVFLQKFQDALKT--ACV-AVAYKTRWRGLVYGLGVYIPFMAYCSATVYGA 989
+++ + FL+ + + T CV + RW L + + + +
Sbjct: 1171 PVIRAFEHQQRFLKHNEVRIDTNQKCVFSWITSNRW------LAIRLELVGNLTVFFSAL 1224
Query: 990 VLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYAPSLNTAKACGARILSIIQRQPKIHN- 1048
++V Y + L ++ A + Q+L + + + + I K+ N
Sbjct: 1225 MMVIYRD---TLSGDTVGFVLSNALNITQTLNWLVRMTSEIETNIVAVERITEYTKVENE 1281
Query: 1049 AVGVKDKK---DWVASGNFSMRDVEFCYPTRPS-QRVLKGIDLKMEAGKTIALVGSSGCG 1104
A V DK+ DW + G + + Y RP VL+GI + + + I +VG +G G
Sbjct: 1282 APWVTDKRPPPDWPSKGKIQFNNYQVRY--RPELDLVLRGITCDIGSMEKIGVVGRTGAG 1339
Query: 1105 KSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYG 1164
KS++ R + G I +D DI S + + LR +L ++ Q+P+L SL N+
Sbjct: 1340 KSSLTNCLFRILEAAGGQIIIDGVDIAS-IGLHDLREKLTIIPQDPILFSGSLRMNL--- 1395
Query: 1165 DNNRKVTMHEIVAAAKAANIHSFIVSLPKAVTEALEKA 1202
D + EI A + A++ SF+ SL ++ + +A
Sbjct: 1396 DPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEA 1433
Score = 50.8 bits (116), Expect = 3e-05
Identities = 22/47 (46%), Positives = 33/47 (70%)
Query: 1207 TCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRMCR 1253
T ITIAHRL T+ D+D + V+D GKI+E G+ EL+ + G ++ M +
Sbjct: 1487 TVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGPFYFMAK 1533
Score = 37.9 bits (84), Expect = 0.23
Identities = 15/45 (33%), Positives = 28/45 (62%)
Query: 1204 KGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHY 1248
KG+T + + H + + D I V+ G IVE+G+++ L++ KG +
Sbjct: 811 KGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEF 855
>AL133353-7|CAI14502.1| 1545|Homo sapiens ATP-binding cassette,
sub-family C (CFTR/MRP), member 2 protein.
Length = 1545
Score = 140 bits (338), Expect = 4e-32
Identities = 128/540 (23%), Positives = 258/540 (47%), Gaps = 35/540 (6%)
Query: 108 MAIGMFISIGVSL-VFCVLSFSLISWSALRQITRIRTLFLRSVLRQDMSWYDTDSEFNLA 166
M +G++ ++G++ +F ++ ++ + + L ++LR M ++DT +
Sbjct: 1022 MRVGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRIV 1081
Query: 167 SKMSENLMSIKEGMGEKL-AVVSNLVG--TSVICLCTAFPLGWQLTLACAAVMPFSVI-T 222
++ + ++ ++ + + + L + ++ +G ++++ +C A P+ T+ V+P +I
Sbjct: 1082 NRFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPV---FTII---VIPLGIIYV 1135
Query: 223 SIALSNYQTKSSIREMESYSLAG--KQAEEILKSVRTIVAFGGENKEVERYRRLLEPAEE 280
S+ + T +R ++S + + E + + I AF + +R+ + E +
Sbjct: 1136 SVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAF----EHQQRFLKHNEVRID 1191
Query: 281 FGRKRGLFTGLGNGFNWVLTYSLNAIG---FSYGTRLVVNDFDTDSNLRQYPVGAVYSIL 337
+K +F+ + + W L L +G + ++V DT L VG V S
Sbjct: 1192 TNQKC-VFSWITSN-RW-LAIRLELVGNLTVFFSALMMVIYRDT---LSGDTVGFVLSNA 1245
Query: 338 FSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPR-RVVGDILL 396
++ TQ++ + V I + E + + K P G I
Sbjct: 1246 LNI---TQTLNWLVRMTSEIETNIVAVERITEYTKVENEAPWVTDKRPPPDWPSKGKIQF 1302
Query: 397 EDVEFCYPSRPEVK-VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXX 455
+ + Y RPE+ VL+G + + E + +VG +G GKS++ L R+ + G +
Sbjct: 1303 NNYQVRY--RPELDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIII 1360
Query: 456 XXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFI 515
LR L ++ Q+P+LF G++ N+ + + EEI + E+A+ F+
Sbjct: 1361 DGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLDPFN-NYSDEEIWKALELAHLKSFV 1419
Query: 516 SLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAAL 575
+ L G + E G +LS GQ+Q + + R+LLR+ +L+LDEAT+A+D ++ +Q +
Sbjct: 1420 ASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTI 1479
Query: 576 DRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKG-FYHKLVTTGNEN 634
T IT++HRL TI+++D+++ +D G I+E G+ E+L++ G FY G EN
Sbjct: 1480 QNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGPFYFMAKEAGIEN 1539
Score = 137 bits (332), Expect = 2e-31
Identities = 186/818 (22%), Positives = 341/818 (41%), Gaps = 65/818 (7%)
Query: 412 LKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSS 471
++ ++ + G+ VA++G G GKS+++ + + G + SW+++
Sbjct: 654 VRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTTAYVPQQSWIQN- 712
Query: 472 LGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGA 531
GTI DNI G+ E + Q+V E + +LP G IGE+G
Sbjct: 713 ------------GTIKDNILFGT-EFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGI 759
Query: 532 SLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASV--GRTTITVS 588
+LSGGQKQRI++AR+ + + LLD+ SA+D H + + L + G+T + V+
Sbjct: 760 NLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVT 819
Query: 589 HRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNEN---KEPADIEPLIE 645
H + + D I+ + G IVE+G++ L+ KG + K + T + +E A + E
Sbjct: 820 HSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLKTFLRHTGPEEEATVHDGSE 879
Query: 646 EADGDGDNIE-----PTVPSRLDVRRRSSKKVLRHHSIKKDHPDWLTPRGSISSMVSIGL 700
E D D I P + + +RR +S + S + + + R S+ + L
Sbjct: 880 EEDDDYGLISSVEEIPEDAASITMRRENSFRRTLSRSSRSNGRHLKSLRNSLKTRNVNSL 939
Query: 701 QNFVFNXXXXXXXXXXXXXTVKTVSDWQLLKLNAPEWPLITVGSIAAFLQGACFPVFAL- 759
+ T K L L A I +A + F L
Sbjct: 940 KEDEELVKGQKLIKKEFIETGKVKFSIYLEYLQAIGLFSIFFIILAFVMNSVAFIGSNLW 999
Query: 760 LFGFSSGIFILDNRDDIIYLADLYSVLFVVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQ 819
L ++S I ++ D D+ ++ + GI + + + + L Q
Sbjct: 1000 LSAWTSDSKIFNSTDYPASQRDMRVGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQ 1059
Query: 820 YFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAI 879
++L+ + FFD T G I R +GD + V + Q + S + FL I
Sbjct: 1060 LLNNILRAPMRFFD--TTPTGRIVNRFAGDISTVDDT-------LPQSLRSWITCFLGII 1110
Query: 880 SYNWKLTLVATVFLPLMV--GSIWLE---GIISQKAQIDERNAMESATAIA--TEAVVSI 932
S + + VF +++ G I++ +S Q+ +++ + + +E V +
Sbjct: 1111 STLVMICMATPVFTIIVIPLGIIYVSVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGL 1170
Query: 933 KTVQSLGVETVFLQKFQDALKT--ACV-AVAYKTRWRGLVYGLGVYIPFMAYCSATVYGA 989
+++ + FL+ + + T CV + RW L + + + +
Sbjct: 1171 PVIRAFEHQQRFLKHNEVRIDTNQKCVFSWITSNRW------LAIRLELVGNLTVFFSAL 1224
Query: 990 VLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYAPSLNTAKACGARILSIIQRQPKIHN- 1048
++V Y + L ++ A + Q+L + + + + I K+ N
Sbjct: 1225 MMVIYRD---TLSGDTVGFVLSNALNITQTLNWLVRMTSEIETNIVAVERITEYTKVENE 1281
Query: 1049 AVGVKDKK---DWVASGNFSMRDVEFCYPTRPS-QRVLKGIDLKMEAGKTIALVGSSGCG 1104
A V DK+ DW + G + + Y RP VL+GI + + + I +VG +G G
Sbjct: 1282 APWVTDKRPPPDWPSKGKIQFNNYQVRY--RPELDLVLRGITCDIGSMEKIGVVGRTGAG 1339
Query: 1105 KSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYG 1164
KS++ R + G I +D DI S + + LR +L ++ Q+P+L SL N+
Sbjct: 1340 KSSLTNCLFRILEAAGGQIIIDGVDIAS-IGLHDLREKLTIIPQDPILFSGSLRMNL--- 1395
Query: 1165 DNNRKVTMHEIVAAAKAANIHSFIVSLPKAVTEALEKA 1202
D + EI A + A++ SF+ SL ++ + +A
Sbjct: 1396 DPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEA 1433
Score = 50.8 bits (116), Expect = 3e-05
Identities = 22/47 (46%), Positives = 33/47 (70%)
Query: 1207 TCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRMCR 1253
T ITIAHRL T+ D+D + V+D GKI+E G+ EL+ + G ++ M +
Sbjct: 1487 TVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGPFYFMAK 1533
Score = 37.9 bits (84), Expect = 0.23
Identities = 15/45 (33%), Positives = 28/45 (62%)
Query: 1204 KGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHY 1248
KG+T + + H + + D I V+ G IVE+G+++ L++ KG +
Sbjct: 811 KGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEF 855
>AL833963-1|CAD38811.1| 453|Homo sapiens hypothetical protein
protein.
Length = 453
Score = 139 bits (337), Expect = 5e-32
Identities = 72/157 (45%), Positives = 95/157 (60%)
Query: 412 LKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSS 471
++ S + PG+ ALVG SG GKS+ + +L+ Y + G V +L
Sbjct: 268 MENVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRV 327
Query: 472 LGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGA 531
+ +V QEPVLF +I DNI+ G P E + A+ A AH FI L +GY T GE+GA
Sbjct: 328 ISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGA 387
Query: 532 SLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSE 568
LSGGQKQR+A+AR+L+R P VL+LDEATSALD SE
Sbjct: 388 QLSGGQKQRVAMARALVRNPPVLILDEATSALDAESE 424
Score = 80.6 bits (190), Expect = 3e-14
Identities = 48/124 (38%), Positives = 68/124 (54%), Gaps = 4/124 (3%)
Query: 1082 LKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRR 1141
++ + + GK ALVG SG GKS+ + + + FY + G + LD + I SA L R
Sbjct: 268 MENVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPI-SAYDHKYLHR 326
Query: 1142 QLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAV-TEALE 1200
+ +V QEPVL RS+ +NI+YG V +V AA+ AN H FI+ L TE E
Sbjct: 327 VISLVSQEPVLFARSITDNISYG--LPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGE 384
Query: 1201 KAAK 1204
K A+
Sbjct: 385 KGAQ 388
Score = 41.1 bits (92), Expect = 0.024
Identities = 42/156 (26%), Positives = 71/156 (45%), Gaps = 11/156 (7%)
Query: 880 SYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIKTVQSLG 939
S +W+L+LV + P+++ + G ++ + +NA+ A+ A E + ++KTV+S
Sbjct: 132 SLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFA 191
Query: 940 VE----TVFLQKFQDALK-TACVAVAYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVAY 994
E V+L+K Q K A AY V+G G+ + + S YG LV
Sbjct: 192 NEEEEAEVYLRKLQQVYKLNRKEAAAYMY----YVWGSGLTL-LVVQVSILYYGGHLVIS 246
Query: 995 GEM-EYKLVLLVNEAIMYGAYMLGQSLVYAPSLNTA 1029
G+M L+ + + G M S +P TA
Sbjct: 247 GQMTSGNLIAFIIYEFVLGDCMENVSFSLSPGKVTA 282
>AF061324-1|AAC16058.1| 1549|Homo sapiens sulfonylurea receptor 2B
protein.
Length = 1549
Score = 138 bits (334), Expect = 1e-31
Identities = 119/513 (23%), Positives = 221/513 (43%), Gaps = 21/513 (4%)
Query: 111 GMFISIGVSLVFCVLSFSLISWSALRQITRIRTLFLRSVLRQDMSWYDTDSEFNLASKMS 170
G I G + C+++ + W L + L ++ + ++DT + ++ S
Sbjct: 1038 GFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFS 1097
Query: 171 ENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPLGWQLTLACAAVMPFSVITSIALSNYQ 230
+ I + + L +L ++++CL + + + A++P V ++
Sbjct: 1098 ADTNIIDQHIPPTL---ESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFR 1154
Query: 231 TKSS-IREMESYSLAGKQAE--EILKSVRTIVAFGGENKEVERYRRLLEPAEEFGRKRGL 287
S ++E++ + E + + TI AF E + +R L + L
Sbjct: 1155 VASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDT----NNIAYL 1210
Query: 288 FTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVYSILFSVYMATQSI 347
F N W L + +G + SN +G +Y++ + Y+
Sbjct: 1211 FLSAAN--RW-LEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITNYLNWVVR 1267
Query: 348 TFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPRRVVGDILLEDVEFCYPSRP 407
++ E +D Q P+ G+I + D+ Y +
Sbjct: 1268 NLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQE--GEIKIHDLCVRYENNL 1325
Query: 408 EVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSW 467
+ VLK ++KPG+ V + G +G GKS++ R+ D G +
Sbjct: 1326 K-PVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHT 1384
Query: 468 LRSSLGVVGQEPVLFRGTIYDNIAIGSPEA--TREEIQRVAEIAYAHDFISLLPNGYDTV 525
LRS L ++ Q+P+LF G+I N+ PE T + + EIA + + LP G D V
Sbjct: 1385 LRSRLSIILQDPILFSGSIRFNL---DPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAV 1441
Query: 526 IGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTI 585
+ E G + S GQ+Q +AR+ +R+ ++L++DEAT+++D +E +Q + A RT +
Sbjct: 1442 VTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVV 1501
Query: 586 TVSHRLSTIVNADRIICMDQGVIVEQGTHEDLM 618
T++HR+ TI+ AD +I M +G I+E T E L+
Sbjct: 1502 TMAHRVHTILTADLVIVMKRGNILEYDTPESLL 1534
Score = 113 bits (271), Expect = 5e-24
Identities = 71/213 (33%), Positives = 107/213 (50%), Gaps = 8/213 (3%)
Query: 412 LKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS- 470
L I + G+ +VG GCGKS++L + G V RS
Sbjct: 688 LSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSR 747
Query: 471 ---SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIG 527
S+ Q+P L T+ +NI GSP ++ + V + I LLP G T IG
Sbjct: 748 NRYSVAYAAQKPWLLNATVEENITFGSP-FNKQRYKAVTDACSLQPDIDLLPFGDQTEIG 806
Query: 528 ERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPH-SERQVQAALDR--ASVGRTT 584
ERG +LSGGQ+QRI +AR+L + ++ LD+ SALD H S+ +Q + + RT
Sbjct: 807 ERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTL 866
Query: 585 ITVSHRLSTIVNADRIICMDQGVIVEQGTHEDL 617
+ V+H+L + +AD II M G ++ +GT +D+
Sbjct: 867 VLVTHKLQYLTHADWIIAMKDGSVLREGTLKDI 899
Score = 70.1 bits (164), Expect = 5e-11
Identities = 107/457 (23%), Positives = 180/457 (39%), Gaps = 34/457 (7%)
Query: 783 YSVLFVVIAAVAGISMCL-QSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGA 841
Y V I AGI +CL S T GL L H ++ I FFD T +G
Sbjct: 1034 YYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFD--TTPLGL 1091
Query: 842 ICARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLMVGSIW 901
I R S DT + + + + + + + + ISY + LVA LPL V +
Sbjct: 1092 ILNRFSADTNIIDQHIPPTLESLTRS-TLLCLSAIGMISYATPVFLVA--LLPLGVAFYF 1148
Query: 902 LEG---IISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVA 958
++ + S+ Q + + +E + T+++ ET F Q+ + T +A
Sbjct: 1149 IQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIA 1208
Query: 959 VAYKT---RWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEYKLVLLVNEAIMYGAYM 1015
+ + RW L V ++ C ++ + L + A+ Y
Sbjct: 1209 YLFLSAANRW------LEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITNY- 1261
Query: 1016 LGQSLVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKD----WVASGNFSMRDVEF 1071
L + L ++ S + + + N G D W G + D+
Sbjct: 1262 LNWVVRNLADLEVQMGAVKKVNSFLTMESE--NYEGTMDPSQVPEHWPQEGEIKIHDLCV 1319
Query: 1072 CYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIR 1131
Y + VLK + ++ G+ + + G +G GKS++ F R D G I +D DI
Sbjct: 1320 RYENN-LKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDI- 1377
Query: 1132 SALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSL 1191
S L + LR +L ++ Q+P+L S+ N+ D K T + A + A + + + SL
Sbjct: 1378 SKLPLHTLRSRLSIILQDPILFSGSIRFNL---DPECKCTDDRLWEALEIAQLKNMVKSL 1434
Query: 1192 P----KAVTEALEKAAKGRTCITIAHRLSTVKDADLI 1224
P VTE E + G+ + R K + LI
Sbjct: 1435 PGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILI 1471
Score = 40.3 bits (90), Expect = 0.043
Identities = 25/86 (29%), Positives = 41/86 (47%), Gaps = 3/86 (3%)
Query: 1082 LKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDN-RDIRSALTIPRLR 1140
L ID+++ G+ +VG GCGKS++L G + N + + R R
Sbjct: 688 LSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSR 747
Query: 1141 RQLGV--VQQEPVLLDRSLAENIAYG 1164
+ V Q+P LL+ ++ ENI +G
Sbjct: 748 NRYSVAYAAQKPWLLNATVEENITFG 773
Score = 39.5 bits (88), Expect = 0.075
Identities = 40/139 (28%), Positives = 62/139 (44%), Gaps = 14/139 (10%)
Query: 1120 SGFIELDNRDIRSALTIPRLRRQLGVVQQEPVL--LDRSLAENIAYGDNNRKVTMHEIVA 1177
SG I N D T RL L + Q + ++ L L + G N V ++
Sbjct: 1400 SGSIRF-NLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFC 1458
Query: 1178 AAKAANIHSFIV-------SLPKAVTEALEK----AAKGRTCITIAHRLSTVKDADLICV 1226
A+A S I+ S+ A L+K A RT +T+AHR+ T+ ADL+ V
Sbjct: 1459 LARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTMAHRVHTILTADLVIV 1518
Query: 1227 IDKGKIVERGTHAELVSMK 1245
+ +G I+E T L++ +
Sbjct: 1519 MKRGNILEYDTPESLLAQE 1537
>AJ132244-1|CAB45309.1| 1545|Homo sapiens multidrug resistance protein
2 (MRP2) protein.
Length = 1545
Score = 137 bits (331), Expect = 3e-31
Identities = 128/540 (23%), Positives = 257/540 (47%), Gaps = 35/540 (6%)
Query: 108 MAIGMFISIGVSL-VFCVLSFSLISWSALRQITRIRTLFLRSVLRQDMSWYDTDSEFNLA 166
M +G++ ++G++ +F ++ ++ + + L ++LR M ++DT +
Sbjct: 1022 MRVGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRIV 1081
Query: 167 SKMSENLMSIKEGMGEKL-AVVSNLVG--TSVICLCTAFPLGWQLTLACAAVMPFSVI-T 222
++ + ++ ++ + + + L + ++ +G ++++ +C A P+ T+ V+P +I
Sbjct: 1082 NRFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPV---FTII---VIPLGIIYV 1135
Query: 223 SIALSNYQTKSSIREMESYSLAG--KQAEEILKSVRTIVAFGGENKEVERYRRLLEPAEE 280
S+ + T +R ++S + + E + + I AF + +R+ + E +
Sbjct: 1136 SVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAF----EHQQRFLKHNEVRID 1191
Query: 281 FGRKRGLFTGLGNGFNWVLTYSLNAIG---FSYGTRLVVNDFDTDSNLRQYPVGAVYSIL 337
+K +F+ + + W L L +G + ++V DT L VG V S
Sbjct: 1192 TNQKC-VFSWITSN-RW-LAIRLELVGNLTVFFSALMMVIYRDT---LSGDTVGFVLSNA 1245
Query: 338 FSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPR-RVVGDILL 396
++ TQ++ + V I + E + + K P G I
Sbjct: 1246 LNI---TQTLNWLVRMTSEIETNIVAVERITEYTKVENEAPWVTDKRPPPDWPSKGKIQF 1302
Query: 397 EDVEFCYPSRPEVK-VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXX 455
+ + Y RPE+ VL+G + + E + +VG +G GKS++ L R+ + G +
Sbjct: 1303 NNYQVRY--RPELDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIII 1360
Query: 456 XXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFI 515
LR L ++ Q+P+LF G++ N+ + + EEI + E+A+ F+
Sbjct: 1361 DGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLDPFN-NYSDEEIWKALELAHLKSFV 1419
Query: 516 SLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAAL 575
+ L G E G +LS GQ+Q + + R+LLR+ +L+LDEAT+A+D ++ +Q +
Sbjct: 1420 ASLQLGLSHEGTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTI 1479
Query: 576 DRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKG-FYHKLVTTGNEN 634
T IT++HRL TI+++D+++ +D G I+E G+ E+L++ G FY G EN
Sbjct: 1480 QNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGPFYFMAKEAGIEN 1539
Score = 136 bits (329), Expect = 5e-31
Identities = 185/807 (22%), Positives = 336/807 (41%), Gaps = 65/807 (8%)
Query: 412 LKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSS 471
++ ++ + G+ VA++G G GKS+++ + + G + SW+++
Sbjct: 654 VRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTTAYVPQQSWIQN- 712
Query: 472 LGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGA 531
GTI DNI G+ E + Q+V E + +LP G IGE+G
Sbjct: 713 ------------GTIKDNILFGT-EFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGI 759
Query: 532 SLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASV--GRTTITVS 588
+LSGGQKQRI++AR+ + + LLD+ SA+D H + + L + G+T + V+
Sbjct: 760 NLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVT 819
Query: 589 HRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNEN---KEPADIEPLIE 645
H + + D I+ + G IVE+G++ L+ KG + K + T + +E A + E
Sbjct: 820 HSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLKTFLRHTGPEEEATVHDGSE 879
Query: 646 EADGDGDNIE-----PTVPSRLDVRRRSSKKVLRHHSIKKDHPDWLTPRGSISSMVSIGL 700
E D D I P + + +RR +S + S + + + R S+ + L
Sbjct: 880 EEDDDYGLISSVEEIPEDAASITMRRENSFRRTLSRSSRSNGRHLKSLRNSLKTRNVNSL 939
Query: 701 QNFVFNXXXXXXXXXXXXXTVKTVSDWQLLKLNAPEWPLITVGSIAAFLQGACFPVFAL- 759
+ T K L L A I +A + F L
Sbjct: 940 KEDEELVKGQKLIKKEFIETGKVKFSIYLEYLQAIGLFSIFFIILAFVMNSVAFIGSNLW 999
Query: 760 LFGFSSGIFILDNRDDIIYLADLYSVLFVVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQ 819
L ++S I ++ D D+ ++ + GI + + + + L Q
Sbjct: 1000 LSAWTSDSKIFNSTDYPASQRDMRVGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQ 1059
Query: 820 YFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAI 879
++L+ + FFD T G I R +GD + V + Q + S + FL I
Sbjct: 1060 LLNNILRAPMRFFD--TTPTGRIVNRFAGDISTVDDT-------LPQSLRSWITCFLGII 1110
Query: 880 SYNWKLTLVATVFLPLMV--GSIWLE---GIISQKAQIDERNAMESATAIA--TEAVVSI 932
S + + VF +++ G I++ +S Q+ +++ + + +E V +
Sbjct: 1111 STLVMICMATPVFTIIVIPLGIIYVSVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGL 1170
Query: 933 KTVQSLGVETVFLQKFQDALKT--ACV-AVAYKTRWRGLVYGLGVYIPFMAYCSATVYGA 989
+++ + FL+ + + T CV + RW L + + + +
Sbjct: 1171 PVIRAFEHQQRFLKHNEVRIDTNQKCVFSWITSNRW------LAIRLELVGNLTVFFSAL 1224
Query: 990 VLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYAPSLNTAKACGARILSIIQRQPKIHN- 1048
++V Y + L ++ A + Q+L + + + + I K+ N
Sbjct: 1225 MMVIYRD---TLSGDTVGFVLSNALNITQTLNWLVRMTSEIETNIVAVERITEYTKVENE 1281
Query: 1049 AVGVKDKK---DWVASGNFSMRDVEFCYPTRPS-QRVLKGIDLKMEAGKTIALVGSSGCG 1104
A V DK+ DW + G + + Y RP VL+GI + + + I +VG +G G
Sbjct: 1282 APWVTDKRPPPDWPSKGKIQFNNYQVRY--RPELDLVLRGITCDIGSMEKIGVVGRTGAG 1339
Query: 1105 KSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYG 1164
KS++ R + G I +D DI S + + LR +L ++ Q+P+L SL N+
Sbjct: 1340 KSSLTNCLFRILEAAGGQIIIDGVDIAS-IGLHDLREKLTIIPQDPILFSGSLRMNL--- 1395
Query: 1165 DNNRKVTMHEIVAAAKAANIHSFIVSL 1191
D + EI A + A++ SF+ SL
Sbjct: 1396 DPFNNYSDEEIWKALELAHLKSFVASL 1422
Score = 50.8 bits (116), Expect = 3e-05
Identities = 22/47 (46%), Positives = 33/47 (70%)
Query: 1207 TCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRMCR 1253
T ITIAHRL T+ D+D + V+D GKI+E G+ EL+ + G ++ M +
Sbjct: 1487 TVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGPFYFMAK 1533
Score = 37.9 bits (84), Expect = 0.23
Identities = 15/45 (33%), Positives = 28/45 (62%)
Query: 1204 KGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHY 1248
KG+T + + H + + D I V+ G IVE+G+++ L++ KG +
Sbjct: 811 KGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEF 855
>X95715-1|CAA65019.1| 453|Homo sapiens anthracycline resistance
associated protein protein.
Length = 453
Score = 136 bits (330), Expect = 4e-31
Identities = 76/233 (32%), Positives = 128/233 (54%), Gaps = 2/233 (0%)
Query: 396 LEDVEFCYPSRPEVKV-LKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVX 454
+E +F RPE+ + ++G S + GE V +VG +G GKS++ L RL + G +
Sbjct: 215 IEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIW 274
Query: 455 XXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDF 514
LRS + ++ Q+P+LF G++ N+ + E + E I E
Sbjct: 275 IDGVPIAHVGVHTLRSRISIIPQDPILFPGSLRMNLDL-LQEHSDEAIWAALETVQLKAL 333
Query: 515 ISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAA 574
++ LP +RG LS GQKQ + +AR+LLR+ +L+LDEAT+A+DP +E Q+QA
Sbjct: 334 VACLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAM 393
Query: 575 LDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKL 627
L T + ++HRL ++++ R++ MD+G + E G+ L+ KG +++L
Sbjct: 394 LGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRL 446
Score = 58.8 bits (136), Expect = 1e-07
Identities = 45/201 (22%), Positives = 92/201 (45%), Gaps = 14/201 (6%)
Query: 1058 WVASGNFSMRDVEFCYPTRPSQRV-LKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFY 1116
W G RD Y RP + ++G+ K+ AG+ + +VG +G GKS++ R
Sbjct: 209 WPQGGQIEFRDFGLRY--RPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQ 266
Query: 1117 DPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIV 1176
+ G I +D I + + + LR ++ ++ Q+P+L SL N+ D ++ + I
Sbjct: 267 EAAEGGIWIDGVPI-AHVGVHTLRSRISIIPQDPILFPGSLRMNL---DLLQEHSDEAIW 322
Query: 1177 AAAKAANIHSFIVSLP-----KAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGK 1231
AA + + + + LP K + + + + +A L ++ ++ + +
Sbjct: 323 AALETVQLKALVACLPGQLQYKCADRGEDLSVGQKQLLCLARAL--LRKTQILILDEATA 380
Query: 1232 IVERGTHAELVSMKGHYWRMC 1252
V+ GT ++ +M G ++ C
Sbjct: 381 AVDPGTELQMQAMLGSWFAQC 401
Score = 46.4 bits (105), Expect = 6e-04
Identities = 19/47 (40%), Positives = 33/47 (70%)
Query: 1207 TCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRMCR 1253
T + IAHRL +V D + V+DKG++ E G+ A+L++ KG ++R+ +
Sbjct: 402 TVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQ 448
>U91318-1|AAC15784.1| 401|Homo sapiens Multiple drug resistance
gene MRP1 (5' partial) protein.
Length = 401
Score = 136 bits (330), Expect = 4e-31
Identities = 74/228 (32%), Positives = 132/228 (57%), Gaps = 2/228 (0%)
Query: 401 FCYPSRPEVK-VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXX 459
+C R ++ VL+ ++ + GE V +VG +G GKS++ L R+ + G +
Sbjct: 168 YCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGIN 227
Query: 460 XXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLP 519
LR + ++ Q+PVLF G++ N+ S + + EE+ E+A+ DF+S LP
Sbjct: 228 IAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFS-QYSDEEVWTSLELAHLKDFVSALP 286
Query: 520 NGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRAS 579
+ D E G +LS GQ+Q + +AR+LLR+ +L+LDEAT+A+D ++ +Q+ +
Sbjct: 287 DKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQF 346
Query: 580 VGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKL 627
T +T++HRL+TI++ R+I +D+G I E G DL++ +G ++ +
Sbjct: 347 EDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSM 394
Score = 48.8 bits (111), Expect = 1e-04
Identities = 35/136 (25%), Positives = 68/136 (50%), Gaps = 7/136 (5%)
Query: 1058 WVASGNFSMRDVEFCYPTRPS-QRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFY 1116
W G R+ +C R VL+ I++ + G+ + +VG +G GKS++ R
Sbjct: 157 WPQVGRVEFRN--YCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRIN 214
Query: 1117 DPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIV 1176
+ G I +D +I + + + LR ++ ++ Q+PVL SL N+ D + + E+
Sbjct: 215 ESAEGEIIIDGINI-AKIGLHDLRFKITIIPQDPVLFSGSLRMNL---DPFSQYSDEEVW 270
Query: 1177 AAAKAANIHSFIVSLP 1192
+ + A++ F+ +LP
Sbjct: 271 TSLELAHLKDFVSALP 286
Score = 46.4 bits (105), Expect = 6e-04
Identities = 37/143 (25%), Positives = 67/143 (46%), Gaps = 18/143 (12%)
Query: 1122 FIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKA 1181
F + + ++ ++L + L+ V P LD AE G N V ++V A+A
Sbjct: 261 FSQYSDEEVWTSLELAHLK---DFVSALPDKLDHECAE----GGENLSVGQRQLVCLARA 313
Query: 1182 ANIHSFIVSLPKA-----------VTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKG 1230
+ I+ L +A + + + T +TIAHRL+T+ D + V+DKG
Sbjct: 314 LLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKG 373
Query: 1231 KIVERGTHAELVSMKGHYWRMCR 1253
+I E G ++L+ +G ++ M +
Sbjct: 374 EIQEYGAPSDLLQQRGLFYSMAK 396
>U83659-1|AAB71756.1| 485|Homo sapiens multidrug
resistance-associated protein homolog protein.
Length = 485
Score = 136 bits (330), Expect = 4e-31
Identities = 71/216 (32%), Positives = 126/216 (58%), Gaps = 3/216 (1%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
VL+ S+HV GE V +VG +G GKS++ R+ + G + +R
Sbjct: 263 VLRDLSLHVHGGEKVGIVGRTGAGKSSMTLACSRILEAAKGEIRIDGLNVADIGFHDVRC 322
Query: 471 SLGVVGQEPVLFRGTIYDNI-AIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGER 529
+ ++ ++P+LF GT+ N+ GS + E+I E+++ H F+S P G D E
Sbjct: 323 QMTIIPRDPILFSGTLRMNLDPFGS--YSEEDIWWALELSHLHTFVSSQPAGLDFQCSEG 380
Query: 530 GASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSH 589
G +LS GQ+Q + +AR+LLR+ +L+LDEAT+A+D ++ +QA + T +T++H
Sbjct: 381 GENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAH 440
Query: 590 RLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYH 625
RL+TI++ R++ +D+GV+ E + +L+ A+G ++
Sbjct: 441 RLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIFY 476
Score = 52.0 bits (119), Expect = 1e-05
Identities = 34/143 (23%), Positives = 69/143 (48%), Gaps = 7/143 (4%)
Query: 1051 GVKDKKDWVASGNFSMRDVEFCYPTRPS-QRVLKGIDLKMEAGKTIALVGSSGCGKSTIL 1109
G + + W G R+ Y RP VL+ + L + G+ + +VG +G GKS++
Sbjct: 234 GSRPPEGWPPRGEVEFRNYSVRY--RPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMT 291
Query: 1110 QLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRK 1169
R + G I +D ++ + + +R Q+ ++ ++P+L +L N+ D
Sbjct: 292 LACSRILEAAKGEIRIDGLNV-ADIGFHDVRCQMTIIPRDPILFSGTLRMNL---DPFGS 347
Query: 1170 VTMHEIVAAAKAANIHSFIVSLP 1192
+ +I A + +++H+F+ S P
Sbjct: 348 YSEEDIWWALELSHLHTFVSSQP 370
Score = 47.6 bits (108), Expect = 3e-04
Identities = 39/124 (31%), Positives = 62/124 (50%), Gaps = 15/124 (12%)
Query: 1146 VQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAV------TEAL 1199
V +P LD +E G N V ++V A+A S I+ L +A T+ L
Sbjct: 366 VSSQPAGLDFQCSE----GGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNL 421
Query: 1200 EKAA---KGRTC--ITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRMCRG 1254
+A + TC +TIAHRL+T+ D + V+DKG + E + A L++ +G ++ M R
Sbjct: 422 IQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIFYGMARD 481
Query: 1255 QNMA 1258
+A
Sbjct: 482 AGLA 485
>BC001636-1|AAH01636.1| 316|Homo sapiens Unknown (protein for
IMAGE:3355848) protein.
Length = 316
Score = 136 bits (330), Expect = 4e-31
Identities = 74/228 (32%), Positives = 132/228 (57%), Gaps = 2/228 (0%)
Query: 401 FCYPSRPEVK-VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXX 459
+C R ++ VL+ ++ + GE V +VG +G GKS++ L R+ + G +
Sbjct: 83 YCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGIN 142
Query: 460 XXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLP 519
LR + ++ Q+PVLF G++ N+ S + + EE+ E+A+ DF+S LP
Sbjct: 143 IAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFS-QYSDEEVWTSLELAHLKDFVSALP 201
Query: 520 NGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRAS 579
+ D E G +LS GQ+Q + +AR+LLR+ +L+LDEAT+A+D ++ +Q+ +
Sbjct: 202 DKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQF 261
Query: 580 VGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKL 627
T +T++HRL+TI++ R+I +D+G I E G DL++ +G ++ +
Sbjct: 262 EDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSM 309
Score = 48.8 bits (111), Expect = 1e-04
Identities = 35/136 (25%), Positives = 68/136 (50%), Gaps = 7/136 (5%)
Query: 1058 WVASGNFSMRDVEFCYPTRPS-QRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFY 1116
W G R+ +C R VL+ I++ + G+ + +VG +G GKS++ R
Sbjct: 72 WPQVGRVEFRN--YCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRIN 129
Query: 1117 DPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIV 1176
+ G I +D +I + + + LR ++ ++ Q+PVL SL N+ D + + E+
Sbjct: 130 ESAEGEIIIDGINI-AKIGLHDLRFKITIIPQDPVLFSGSLRMNL---DPFSQYSDEEVW 185
Query: 1177 AAAKAANIHSFIVSLP 1192
+ + A++ F+ +LP
Sbjct: 186 TSLELAHLKDFVSALP 201
Score = 46.4 bits (105), Expect = 6e-04
Identities = 37/143 (25%), Positives = 67/143 (46%), Gaps = 18/143 (12%)
Query: 1122 FIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKA 1181
F + + ++ ++L + L+ V P LD AE G N V ++V A+A
Sbjct: 176 FSQYSDEEVWTSLELAHLK---DFVSALPDKLDHECAE----GGENLSVGQRQLVCLARA 228
Query: 1182 ANIHSFIVSLPKA-----------VTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKG 1230
+ I+ L +A + + + T +TIAHRL+T+ D + V+DKG
Sbjct: 229 LLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKG 288
Query: 1231 KIVERGTHAELVSMKGHYWRMCR 1253
+I E G ++L+ +G ++ M +
Sbjct: 289 EIQEYGAPSDLLQQRGLFYSMAK 311
>AF168791-1|AAD51293.1| 1503|Homo sapiens multi-specific organic anion
tranporter-E protein.
Length = 1503
Score = 136 bits (330), Expect = 4e-31
Identities = 76/233 (32%), Positives = 128/233 (54%), Gaps = 2/233 (0%)
Query: 396 LEDVEFCYPSRPEVKV-LKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVX 454
+E +F RPE+ + ++G S + GE V +VG +G GKS++ L RL + G +
Sbjct: 1265 IEFRDFGLRCRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIW 1324
Query: 455 XXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDF 514
LRS + ++ Q+P+LF G++ N+ + E + E I E
Sbjct: 1325 IDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDL-LQEHSDEAIWAALETVQLKAL 1383
Query: 515 ISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAA 574
++ LP +RG LS GQKQ + +AR+LLR+ +L+LDEAT+A+DP +E Q+QA
Sbjct: 1384 VASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAM 1443
Query: 575 LDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKL 627
L T + ++HRL ++++ R++ MD+G + E G+ L+ KG +++L
Sbjct: 1444 LGSWFAQCTVLPIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRL 1496
Score = 102 bits (245), Expect = 7e-21
Identities = 131/570 (22%), Positives = 231/570 (40%), Gaps = 35/570 (6%)
Query: 108 MAIGMFISIGVSLVFCVLSFSLISWSALRQITRIRTLFLRSVLRQDMSWYDTDSEFNLAS 167
+A+ MF+S + +F + + +R + I L R VL + ++ +
Sbjct: 352 LAVLMFLSACLQTLFEQQNMYRLKVPQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVN 411
Query: 168 KMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPLGWQLTLACAAVMPFSVITSIALS 227
+S ++ + E + + LV V+C + L L AV + + +S
Sbjct: 412 LVSVDVQRLTESVLYLNGLWLPLVWI-VVCFVYLWQLLGPSALTAIAVFLSLLPLNFFIS 470
Query: 228 NYQTKSSIREMESYSLAGKQAEEILKSVRTIVAFGGENKEVERYRRLLEPAEEFG--RKR 285
+ +M + IL++ +TI G E ++R + +E G R
Sbjct: 471 KKRNHHQEEQMRQKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIR--GQELGALRTS 528
Query: 286 GLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVYSILFSVYMATQ 345
GL + V T+ + + F+ T + N + + ++L + A
Sbjct: 529 GLLFSVSLVSFQVSTFLVALVVFAVHTLVAENAMNAEKAF------VTLTVLNILNKAQA 582
Query: 346 SITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPRRVVGDILLEDVEFCYPS 405
+ F + L + L E +P + G + I + F + S
Sbjct: 583 FLPFSIHSLVQARVSFDRLVTFLCLEEVDPGVVDSSSSGSAAGKDC--ITIHSATFAW-S 639
Query: 406 RPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXX 465
+ L ++ V G +A+VG G GKS++L L G V
Sbjct: 640 QESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVS----------- 688
Query: 466 SWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTV 525
+ ++ V QE + ++ +N+ G E ++RV E + P G T
Sbjct: 689 --IEGAVAYVPQEAWVQNTSVVENVCFGQ-ELDPPWLERVLEACALQPDVDSFPEGIHTS 745
Query: 526 IGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASV--GR 582
IGE+G +LSGGQKQR+++AR++ R+ AV LLD+ +ALD H + V + + G
Sbjct: 746 IGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGT 805
Query: 583 TTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENKEPADI-E 641
T I V+H L + AD II + G I E G++++L++ KG LV ++ ++P D E
Sbjct: 806 TRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKG---ALVCLLDQARQPGDRGE 862
Query: 642 PLIEEADGDGDNIEPTVPSRLDVRRRSSKK 671
E D + R ++RR S K
Sbjct: 863 GETEPGTSTKDPRGTSAGRRPELRRERSIK 892
Score = 61.7 bits (143), Expect = 2e-08
Identities = 46/201 (22%), Positives = 92/201 (45%), Gaps = 14/201 (6%)
Query: 1058 WVASGNFSMRDVEF-CYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFY 1116
W G RD C P P ++G+ K+ AG+ + +VG +G GKS++ R
Sbjct: 1259 WPQGGQIEFRDFGLRCRPELPL--AVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQ 1316
Query: 1117 DPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIV 1176
+ G I +D I + + + LR ++ ++ Q+P+L SL N+ D ++ + I
Sbjct: 1317 EAAEGGIWIDGVPI-AHVGLHTLRSRISIIPQDPILFPGSLRMNL---DLLQEHSDEAIW 1372
Query: 1177 AAAKAANIHSFIVSLP-----KAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGK 1231
AA + + + + SLP K + + + + +A L ++ ++ + +
Sbjct: 1373 AALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARAL--LRKTQILILDEATA 1430
Query: 1232 IVERGTHAELVSMKGHYWRMC 1252
V+ GT ++ +M G ++ C
Sbjct: 1431 AVDPGTELQMQAMLGSWFAQC 1451
Score = 46.4 bits (105), Expect = 6e-04
Identities = 19/47 (40%), Positives = 33/47 (70%)
Query: 1207 TCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRMCR 1253
T + IAHRL +V D + V+DKG++ E G+ A+L++ KG ++R+ +
Sbjct: 1452 TVLPIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQ 1498
>BC131732-1|AAI31733.1| 1503|Homo sapiens ATP-binding cassette,
sub-family C (CFTR/MRP), member 6 protein.
Length = 1503
Score = 136 bits (329), Expect = 5e-31
Identities = 76/233 (32%), Positives = 128/233 (54%), Gaps = 2/233 (0%)
Query: 396 LEDVEFCYPSRPEVKV-LKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVX 454
+E +F RPE+ + ++G S + GE V +VG +G GKS++ L RL + G +
Sbjct: 1265 IEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIW 1324
Query: 455 XXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDF 514
LRS + ++ Q+P+LF G++ N+ + E + E I E
Sbjct: 1325 IDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDL-LQEHSDEAIWAALETVQLKAL 1383
Query: 515 ISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAA 574
++ LP +RG LS GQKQ + +AR+LLR+ +L+LDEAT+A+DP +E Q+QA
Sbjct: 1384 VASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAM 1443
Query: 575 LDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKL 627
L T + ++HRL ++++ R++ MD+G + E G+ L+ KG +++L
Sbjct: 1444 LGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRL 1496
Score = 101 bits (242), Expect = 2e-20
Identities = 131/570 (22%), Positives = 231/570 (40%), Gaps = 35/570 (6%)
Query: 108 MAIGMFISIGVSLVFCVLSFSLISWSALRQITRIRTLFLRSVLRQDMSWYDTDSEFNLAS 167
+A+ MF+S + +F + + +R + I L R VL + ++ +
Sbjct: 352 LAVLMFLSACLQTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVN 411
Query: 168 KMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPLGWQLTLACAAVMPFSVITSIALS 227
+S ++ + E + + LV V+C + L L AV + + +S
Sbjct: 412 LVSVDVQRLTESVLYLNGLWLPLVWI-VVCFVYLWQLLGPSALTAIAVFLSLLPLNFFIS 470
Query: 228 NYQTKSSIREMESYSLAGKQAEEILKSVRTIVAFGGENKEVERYRRLLEPAEEFG--RKR 285
+ +M + IL++ +TI G E ++R + +E G R
Sbjct: 471 KKRNHHQEEQMRQKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIR--GQELGALRTS 528
Query: 286 GLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVYSILFSVYMATQ 345
GL + V T+ + + F+ T + N + + ++L + A
Sbjct: 529 GLLFSVSLVSFQVSTFLVALVVFAVHTLVAENAMNAEKAF------VTLTVLNILNKAQA 582
Query: 346 SITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPRRVVGDILLEDVEFCYPS 405
+ F + L + L E +P G + I ++ F + S
Sbjct: 583 FLPFSIHSLVQARVSFDRLVTFLCLEEVDPGAVDSSSSGSAAGKDC--ITIQSATFAW-S 639
Query: 406 RPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXX 465
+ L ++ V G +A+VG G GKS++L L G V
Sbjct: 640 QESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVS----------- 688
Query: 466 SWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTV 525
+ ++ V QE + ++ +N+ G E ++RV E + P G T
Sbjct: 689 --IEGAVAYVPQEAWVQNTSVVENVCFGQ-ELDPPWLERVLEACALQPDVDSFPEGIHTS 745
Query: 526 IGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASV--GR 582
IGE+G +LSGGQKQR+++AR++ R+ AV LLD+ +ALD H + V + + G
Sbjct: 746 IGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGT 805
Query: 583 TTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENKEPADI-E 641
T I V+H L + AD II + G I E G++++L++ KG LV ++ ++P D E
Sbjct: 806 TRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKG---ALVCLLDQARQPGDRGE 862
Query: 642 PLIEEADGDGDNIEPTVPSRLDVRRRSSKK 671
E D + R ++RR S K
Sbjct: 863 GETEPGTSTKDPRGTSAGRRPELRRERSIK 892
Score = 60.5 bits (140), Expect = 4e-08
Identities = 46/201 (22%), Positives = 93/201 (46%), Gaps = 14/201 (6%)
Query: 1058 WVASGNFSMRDVEFCYPTRPSQRV-LKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFY 1116
W G RD Y RP + ++G+ K+ AG+ + +VG +G GKS++ R
Sbjct: 1259 WPQGGQIEFRDFGLRY--RPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQ 1316
Query: 1117 DPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIV 1176
+ G I +D I + + + LR ++ ++ Q+P+L SL N+ D ++ + I
Sbjct: 1317 EAAEGGIWIDGVPI-AHVGLHTLRSRISIIPQDPILFPGSLRMNL---DLLQEHSDEAIW 1372
Query: 1177 AAAKAANIHSFIVSLP-----KAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGK 1231
AA + + + + SLP K + + + + +A L ++ ++ + +
Sbjct: 1373 AALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARAL--LRKTQILILDEATA 1430
Query: 1232 IVERGTHAELVSMKGHYWRMC 1252
V+ GT ++ +M G ++ C
Sbjct: 1431 AVDPGTELQMQAMLGSWFAQC 1451
Score = 46.4 bits (105), Expect = 6e-04
Identities = 19/47 (40%), Positives = 33/47 (70%)
Query: 1207 TCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRMCR 1253
T + IAHRL +V D + V+DKG++ E G+ A+L++ KG ++R+ +
Sbjct: 1452 TVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQ 1498
>BC024103-1|AAH24103.1| 282|Homo sapiens ABCC10 protein protein.
Length = 282
Score = 136 bits (329), Expect = 5e-31
Identities = 75/220 (34%), Positives = 125/220 (56%), Gaps = 5/220 (2%)
Query: 392 GDILLEDVEFCY-PSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQA 450
G + +DV Y P P L G + V+PGE + +VG +G GKS++L +L RL +P +
Sbjct: 34 GGVEFQDVVLAYRPGLPNA--LDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSS 91
Query: 451 GSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAY 510
G V + LRS L ++ QEP LF GT+ +N+ R Q + +
Sbjct: 92 GRVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCHL 151
Query: 511 AHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQ 570
+ S+ G D +GE G SLS GQ+Q + +AR+LL + +L +DEAT+++D +++
Sbjct: 152 SEVITSM--GGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQL 209
Query: 571 VQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVE 610
+Q + + +T +T++HRL+TI+N+DR++ + G +VE
Sbjct: 210 LQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVE 249
Score = 70.1 bits (164), Expect = 5e-11
Identities = 48/182 (26%), Positives = 88/182 (48%), Gaps = 7/182 (3%)
Query: 1058 WVASGNFSMRDVEFCYPTRPS-QRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFY 1116
W+ G +DV Y RP L G+ ++ G+ + +VG +G GKS++L + R
Sbjct: 30 WLTQGGVEFQDVVLAY--RPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLL 87
Query: 1117 DPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIV 1176
+P SG + LD D S L + +LR QL ++ QEP L ++ EN+ ++ + + +
Sbjct: 88 EPSSGRVLLDGVD-TSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQAL 146
Query: 1177 AAAKAANIHSFIVSLPKAVTEALEKAAKG-RTCITIAHRLSTVKDADLICVIDKGKIVER 1235
+ + + + L + E + G R + +A L T DA ++C+ + V++
Sbjct: 147 KQCHLSEVITSMGGLDGELGEGGRSLSLGQRQLLCLARALLT--DAKILCIDEATASVDQ 204
Query: 1236 GT 1237
T
Sbjct: 205 KT 206
Score = 37.5 bits (83), Expect = 0.30
Identities = 26/96 (27%), Positives = 46/96 (47%), Gaps = 7/96 (7%)
Query: 1153 LDRSLAE---NIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAVTEALE----KAAKG 1205
LD L E +++ G ++ AK I S+ + + L+ K
Sbjct: 161 LDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRFAN 220
Query: 1206 RTCITIAHRLSTVKDADLICVIDKGKIVERGTHAEL 1241
+T +TIAHRL+T+ ++D + V+ G++VE + A L
Sbjct: 221 KTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATL 256
>AL359813-2|CAI23217.1| 1492|Homo sapiens ATP-binding cassette,
sub-family C (CFTR/MRP), member 10 protein.
Length = 1492
Score = 136 bits (329), Expect = 5e-31
Identities = 75/220 (34%), Positives = 125/220 (56%), Gaps = 5/220 (2%)
Query: 392 GDILLEDVEFCY-PSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQA 450
G + +DV Y P P L G + V+PGE + +VG +G GKS++L +L RL +P +
Sbjct: 1244 GGVEFQDVVLAYRPGLPNA--LDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSS 1301
Query: 451 GSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAY 510
G V + LRS L ++ QEP LF GT+ +N+ R Q + +
Sbjct: 1302 GRVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCHL 1361
Query: 511 AHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQ 570
+ S+ G D +GE G SLS GQ+Q + +AR+LL + +L +DEAT+++D +++
Sbjct: 1362 SEVITSM--GGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQL 1419
Query: 571 VQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVE 610
+Q + + +T +T++HRL+TI+N+DR++ + G +VE
Sbjct: 1420 LQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVE 1459
Score = 92.3 bits (219), Expect = 1e-17
Identities = 61/203 (30%), Positives = 98/203 (48%), Gaps = 12/203 (5%)
Query: 417 IHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVG 476
+ VK G V +VG GCGKS++L + G V L G+
Sbjct: 621 LEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRG----------LSKGFGLAT 670
Query: 477 QEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGG 536
QEP + TI DNI G + + V E +D +S+LP G T +GE+G +LSGG
Sbjct: 671 QEPWIQFATIRDNILFGKT-FDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGG 729
Query: 537 QKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTT-ITVSHRLSTIV 595
Q+ RIA+AR++ +E + LLD+ +A+D + + TT + +HR +
Sbjct: 730 QRARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRLLCTHRTEYLE 789
Query: 596 NADRIICMDQGVIVEQGTHEDLM 618
AD ++ M+ G ++ G +++
Sbjct: 790 RADAVLLMEAGRLIRAGPPSEIL 812
Score = 70.1 bits (164), Expect = 5e-11
Identities = 48/182 (26%), Positives = 88/182 (48%), Gaps = 7/182 (3%)
Query: 1058 WVASGNFSMRDVEFCYPTRPS-QRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFY 1116
W+ G +DV Y RP L G+ ++ G+ + +VG +G GKS++L + R
Sbjct: 1240 WLTQGGVEFQDVVLAY--RPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLL 1297
Query: 1117 DPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIV 1176
+P SG + LD D S L + +LR QL ++ QEP L ++ EN+ ++ + + +
Sbjct: 1298 EPSSGRVLLDGVD-TSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQAL 1356
Query: 1177 AAAKAANIHSFIVSLPKAVTEALEKAAKG-RTCITIAHRLSTVKDADLICVIDKGKIVER 1235
+ + + + L + E + G R + +A L T DA ++C+ + V++
Sbjct: 1357 KQCHLSEVITSMGGLDGELGEGGRSLSLGQRQLLCLARALLT--DAKILCIDEATASVDQ 1414
Query: 1236 GT 1237
T
Sbjct: 1415 KT 1416
Score = 37.5 bits (83), Expect = 0.30
Identities = 26/96 (27%), Positives = 46/96 (47%), Gaps = 7/96 (7%)
Query: 1153 LDRSLAE---NIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAVTEALE----KAAKG 1205
LD L E +++ G ++ AK I S+ + + L+ K
Sbjct: 1371 LDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRFAN 1430
Query: 1206 RTCITIAHRLSTVKDADLICVIDKGKIVERGTHAEL 1241
+T +TIAHRL+T+ ++D + V+ G++VE + A L
Sbjct: 1431 KTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATL 1466
>AL133613-1|CAB63742.1| 700|Homo sapiens hypothetical protein
protein.
Length = 700
Score = 136 bits (329), Expect = 5e-31
Identities = 75/220 (34%), Positives = 125/220 (56%), Gaps = 5/220 (2%)
Query: 392 GDILLEDVEFCY-PSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQA 450
G + +DV Y P P L G + V+PGE + +VG +G GKS++L +L RL +P +
Sbjct: 452 GGVEFQDVVLAYRPGLPNA--LDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSS 509
Query: 451 GSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAY 510
G V + LRS L ++ QEP LF GT+ +N+ R Q + +
Sbjct: 510 GRVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCHL 569
Query: 511 AHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQ 570
+ S+ G D +GE G SLS GQ+Q + +AR+LL + +L +DEAT+++D +++
Sbjct: 570 SEVITSM--GGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQL 627
Query: 571 VQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVE 610
+Q + + +T +T++HRL+TI+N+DR++ + G +VE
Sbjct: 628 LQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVE 667
Score = 70.1 bits (164), Expect = 5e-11
Identities = 48/182 (26%), Positives = 88/182 (48%), Gaps = 7/182 (3%)
Query: 1058 WVASGNFSMRDVEFCYPTRPS-QRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFY 1116
W+ G +DV Y RP L G+ ++ G+ + +VG +G GKS++L + R
Sbjct: 448 WLTQGGVEFQDVVLAY--RPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLL 505
Query: 1117 DPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIV 1176
+P SG + LD D S L + +LR QL ++ QEP L ++ EN+ ++ + + +
Sbjct: 506 EPSSGRVLLDGVD-TSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQAL 564
Query: 1177 AAAKAANIHSFIVSLPKAVTEALEKAAKG-RTCITIAHRLSTVKDADLICVIDKGKIVER 1235
+ + + + L + E + G R + +A L T DA ++C+ + V++
Sbjct: 565 KQCHLSEVITSMGGLDGELGEGGRSLSLGQRQLLCLARALLT--DAKILCIDEATASVDQ 622
Query: 1236 GT 1237
T
Sbjct: 623 KT 624
Score = 37.5 bits (83), Expect = 0.30
Identities = 26/96 (27%), Positives = 46/96 (47%), Gaps = 7/96 (7%)
Query: 1153 LDRSLAE---NIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAVTEALE----KAAKG 1205
LD L E +++ G ++ AK I S+ + + L+ K
Sbjct: 579 LDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRFAN 638
Query: 1206 RTCITIAHRLSTVKDADLICVIDKGKIVERGTHAEL 1241
+T +TIAHRL+T+ ++D + V+ G++VE + A L
Sbjct: 639 KTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATL 674
>AK024446-1|BAB15736.1| 706|Homo sapiens FLJ00036 protein protein.
Length = 706
Score = 136 bits (329), Expect = 5e-31
Identities = 75/220 (34%), Positives = 125/220 (56%), Gaps = 5/220 (2%)
Query: 392 GDILLEDVEFCY-PSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQA 450
G + +DV Y P P L G + V+PGE + +VG +G GKS++L +L RL +P +
Sbjct: 458 GGVEFQDVVLAYRPGLPNA--LDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSS 515
Query: 451 GSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAY 510
G V + LRS L ++ QEP LF GT+ +N+ R Q + +
Sbjct: 516 GRVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCHL 575
Query: 511 AHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQ 570
+ S+ G D +GE G SLS GQ+Q + +AR+LL + +L +DEAT+++D +++
Sbjct: 576 SEVITSM--GGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQL 633
Query: 571 VQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVE 610
+Q + + +T +T++HRL+TI+N+DR++ + G +VE
Sbjct: 634 LQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVE 673
Score = 70.1 bits (164), Expect = 5e-11
Identities = 48/182 (26%), Positives = 88/182 (48%), Gaps = 7/182 (3%)
Query: 1058 WVASGNFSMRDVEFCYPTRPS-QRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFY 1116
W+ G +DV Y RP L G+ ++ G+ + +VG +G GKS++L + R
Sbjct: 454 WLTQGGVEFQDVVLAY--RPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLL 511
Query: 1117 DPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIV 1176
+P SG + LD D S L + +LR QL ++ QEP L ++ EN+ ++ + + +
Sbjct: 512 EPSSGRVLLDGVD-TSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQAL 570
Query: 1177 AAAKAANIHSFIVSLPKAVTEALEKAAKG-RTCITIAHRLSTVKDADLICVIDKGKIVER 1235
+ + + + L + E + G R + +A L T DA ++C+ + V++
Sbjct: 571 KQCHLSEVITSMGGLDGELGEGGRSLSLGQRQLLCLARALLT--DAKILCIDEATASVDQ 628
Query: 1236 GT 1237
T
Sbjct: 629 KT 630
Score = 37.5 bits (83), Expect = 0.30
Identities = 26/96 (27%), Positives = 46/96 (47%), Gaps = 7/96 (7%)
Query: 1153 LDRSLAE---NIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAVTEALE----KAAKG 1205
LD L E +++ G ++ AK I S+ + + L+ K
Sbjct: 585 LDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRFAN 644
Query: 1206 RTCITIAHRLSTVKDADLICVIDKGKIVERGTHAEL 1241
+T +TIAHRL+T+ ++D + V+ G++VE + A L
Sbjct: 645 KTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATL 680
>AK000002-1|BAA92227.1| 1513|Homo sapiens FLJ00002 protein protein.
Length = 1513
Score = 136 bits (329), Expect = 5e-31
Identities = 75/220 (34%), Positives = 125/220 (56%), Gaps = 5/220 (2%)
Query: 392 GDILLEDVEFCY-PSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQA 450
G + +DV Y P P L G + V+PGE + +VG +G GKS++L +L RL +P +
Sbjct: 1265 GGVEFQDVVLAYRPGLPNA--LDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSS 1322
Query: 451 GSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAY 510
G V + LRS L ++ QEP LF GT+ +N+ R Q + +
Sbjct: 1323 GRVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCHL 1382
Query: 511 AHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQ 570
+ S+ G D +GE G SLS GQ+Q + +AR+LL + +L +DEAT+++D +++
Sbjct: 1383 SEVITSM--GGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQL 1440
Query: 571 VQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVE 610
+Q + + +T +T++HRL+TI+N+DR++ + G +VE
Sbjct: 1441 LQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVE 1480
Score = 92.3 bits (219), Expect = 1e-17
Identities = 61/203 (30%), Positives = 98/203 (48%), Gaps = 12/203 (5%)
Query: 417 IHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVG 476
+ VK G V +VG GCGKS++L + G V L G+
Sbjct: 642 LEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRG----------LSKGFGLAT 691
Query: 477 QEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGG 536
QEP + TI DNI G + + V E +D +S+LP G T +GE+G +LSGG
Sbjct: 692 QEPWIQFATIRDNILFGKT-FDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGG 750
Query: 537 QKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTT-ITVSHRLSTIV 595
Q+ RIA+AR++ +E + LLD+ +A+D + + TT + +HR +
Sbjct: 751 QRARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRLLCTHRTEYLE 810
Query: 596 NADRIICMDQGVIVEQGTHEDLM 618
AD ++ M+ G ++ G +++
Sbjct: 811 RADAVLLMEAGRLIRAGPPSEIL 833
Score = 70.1 bits (164), Expect = 5e-11
Identities = 48/182 (26%), Positives = 88/182 (48%), Gaps = 7/182 (3%)
Query: 1058 WVASGNFSMRDVEFCYPTRPS-QRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFY 1116
W+ G +DV Y RP L G+ ++ G+ + +VG +G GKS++L + R
Sbjct: 1261 WLTQGGVEFQDVVLAY--RPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLL 1318
Query: 1117 DPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIV 1176
+P SG + LD D S L + +LR QL ++ QEP L ++ EN+ ++ + + +
Sbjct: 1319 EPSSGRVLLDGVD-TSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQAL 1377
Query: 1177 AAAKAANIHSFIVSLPKAVTEALEKAAKG-RTCITIAHRLSTVKDADLICVIDKGKIVER 1235
+ + + + L + E + G R + +A L T DA ++C+ + V++
Sbjct: 1378 KQCHLSEVITSMGGLDGELGEGGRSLSLGQRQLLCLARALLT--DAKILCIDEATASVDQ 1435
Query: 1236 GT 1237
T
Sbjct: 1436 KT 1437
Score = 37.5 bits (83), Expect = 0.30
Identities = 26/96 (27%), Positives = 46/96 (47%), Gaps = 7/96 (7%)
Query: 1153 LDRSLAE---NIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAVTEALE----KAAKG 1205
LD L E +++ G ++ AK I S+ + + L+ K
Sbjct: 1392 LDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRFAN 1451
Query: 1206 RTCITIAHRLSTVKDADLICVIDKGKIVERGTHAEL 1241
+T +TIAHRL+T+ ++D + V+ G++VE + A L
Sbjct: 1452 KTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATL 1487
>AF076622-1|AAC79696.1| 1503|Homo sapiens MRP6 protein.
Length = 1503
Score = 136 bits (329), Expect = 5e-31
Identities = 76/233 (32%), Positives = 128/233 (54%), Gaps = 2/233 (0%)
Query: 396 LEDVEFCYPSRPEVKV-LKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVX 454
+E +F RPE+ + ++G S + GE V +VG +G GKS++ L RL + G +
Sbjct: 1265 IEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIW 1324
Query: 455 XXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDF 514
LRS + ++ Q+P+LF G++ N+ + E + E I E
Sbjct: 1325 IDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDL-LQEHSDEAIWAALETVQLKAL 1383
Query: 515 ISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAA 574
++ LP +RG LS GQKQ + +AR+LLR+ +L+LDEAT+A+DP +E Q+QA
Sbjct: 1384 VASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAM 1443
Query: 575 LDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKL 627
L T + ++HRL ++++ R++ MD+G + E G+ L+ KG +++L
Sbjct: 1444 LGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRL 1496
Score = 102 bits (244), Expect = 9e-21
Identities = 131/570 (22%), Positives = 231/570 (40%), Gaps = 35/570 (6%)
Query: 108 MAIGMFISIGVSLVFCVLSFSLISWSALRQITRIRTLFLRSVLRQDMSWYDTDSEFNLAS 167
+A+ MF+S + +F + + +R + I L R VL + ++ +
Sbjct: 352 LAVLMFLSACLQTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVN 411
Query: 168 KMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPLGWQLTLACAAVMPFSVITSIALS 227
+S ++ + E + + LV V+C + L L AV + + +S
Sbjct: 412 LVSVDVQRLTESVLYLNGLWLPLVWI-VVCFVYLWQLLGPSALTAIAVFLSLLPLNFFIS 470
Query: 228 NYQTKSSIREMESYSLAGKQAEEILKSVRTIVAFGGENKEVERYRRLLEPAEEFG--RKR 285
+ +M + IL++ +TI G E ++R + +E G R
Sbjct: 471 KKRNHHQEEQMRQKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIR--GQELGALRTS 528
Query: 286 GLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVYSILFSVYMATQ 345
GL + V T+ + + F+ T + N + + ++L + A
Sbjct: 529 GLLFSVSLVSFQVSTFLVALVVFAVHTLVAENAMNAEKAF------VTLTVLNILNKAQA 582
Query: 346 SITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPRRVVGDILLEDVEFCYPS 405
+ F + L + L E +P + G + I + F + S
Sbjct: 583 FLPFSIHSLVQARVSFDRLVTFLCLEEVDPGVVDSSSSGSAAGKDC--ITIHSATFAW-S 639
Query: 406 RPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXX 465
+ L ++ V G +A+VG G GKS++L L G V
Sbjct: 640 QESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVS----------- 688
Query: 466 SWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTV 525
+ ++ V QE + ++ +N+ G E ++RV E + P G T
Sbjct: 689 --IEGAVAYVPQEAWVQNTSVVENVCFGQ-ELDPPWLERVLEACALQPDVDSFPEGIHTS 745
Query: 526 IGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASV--GR 582
IGE+G +LSGGQKQR+++AR++ R+ AV LLD+ +ALD H + V + + G
Sbjct: 746 IGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGT 805
Query: 583 TTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENKEPADI-E 641
T I V+H L + AD II + G I E G++++L++ KG LV ++ ++P D E
Sbjct: 806 TRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKG---ALVCLLDQARQPGDRGE 862
Query: 642 PLIEEADGDGDNIEPTVPSRLDVRRRSSKK 671
E D + R ++RR S K
Sbjct: 863 GETEPGTSTKDPRGTSAGRRPELRRERSIK 892
Score = 60.5 bits (140), Expect = 4e-08
Identities = 46/201 (22%), Positives = 93/201 (46%), Gaps = 14/201 (6%)
Query: 1058 WVASGNFSMRDVEFCYPTRPSQRV-LKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFY 1116
W G RD Y RP + ++G+ K+ AG+ + +VG +G GKS++ R
Sbjct: 1259 WPQGGQIEFRDFGLRY--RPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQ 1316
Query: 1117 DPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIV 1176
+ G I +D I + + + LR ++ ++ Q+P+L SL N+ D ++ + I
Sbjct: 1317 EAAEGGIWIDGVPI-AHVGLHTLRSRISIIPQDPILFPGSLRMNL---DLLQEHSDEAIW 1372
Query: 1177 AAAKAANIHSFIVSLP-----KAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGK 1231
AA + + + + SLP K + + + + +A L ++ ++ + +
Sbjct: 1373 AALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARAL--LRKTQILILDEATA 1430
Query: 1232 IVERGTHAELVSMKGHYWRMC 1252
V+ GT ++ +M G ++ C
Sbjct: 1431 AVDPGTELQMQAMLGSWFAQC 1451
Score = 46.4 bits (105), Expect = 6e-04
Identities = 19/47 (40%), Positives = 33/47 (70%)
Query: 1207 TCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRMCR 1253
T + IAHRL +V D + V+DKG++ E G+ A+L++ KG ++R+ +
Sbjct: 1452 TVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQ 1498
>AF061323-1|AAC16057.1| 1549|Homo sapiens sulfonylurea receptor 2A
protein.
Length = 1549
Score = 135 bits (327), Expect = 8e-31
Identities = 120/526 (22%), Positives = 227/526 (43%), Gaps = 22/526 (4%)
Query: 111 GMFISIGVSLVFCVLSFSLISWSALRQITRIRTLFLRSVLRQDMSWYDTDSEFNLASKMS 170
G I G + C+++ + W L + L ++ + ++DT + ++ S
Sbjct: 1038 GFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFS 1097
Query: 171 ENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPLGWQLTLACAAVMPFSVITSIALSNYQ 230
+ I + + L +L ++++CL + + + A++P V ++
Sbjct: 1098 ADTNIIDQHIPPTL---ESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFR 1154
Query: 231 TKSS-IREMESYSLAGKQAE--EILKSVRTIVAFGGENKEVERYRRLLEPAEEFGRKRGL 287
S ++E++ + E + + TI AF E + +R L + L
Sbjct: 1155 VASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDT----NNIAYL 1210
Query: 288 FTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVYSILFSVYMATQSI 347
F N W L + +G + SN +G +Y++ + Y+
Sbjct: 1211 FLSAAN--RW-LEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITNYLNWVVR 1267
Query: 348 TFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPRRVVGDILLEDVEFCYPSRP 407
++ E +D Q P+ G+I + D+ Y +
Sbjct: 1268 NLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQE--GEIKIHDLCVRYENNL 1325
Query: 408 EVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSW 467
+ VLK ++KPG+ V + G +G GKS++ R+ D G +
Sbjct: 1326 K-PVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHT 1384
Query: 468 LRSSLGVVGQEPVLFRGTIYDNIAIGSPEA--TREEIQRVAEIAYAHDFISLLPNGYDTV 525
LRS L ++ Q+P+LF G+I N+ PE T + + EIA + + LP G D V
Sbjct: 1385 LRSRLSIILQDPILFSGSIRFNL---DPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAV 1441
Query: 526 IGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTI 585
+ E G + S GQ+Q +AR+ +R+ ++L++DEAT+++D +E +Q + A RT +
Sbjct: 1442 VTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVV 1501
Query: 586 TVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAK-GFYHKLVTT 630
T++HR+S+I++A ++ +G++VE T +L K G + LV T
Sbjct: 1502 TMAHRVSSIMDAGLVLVFSEGILVECDTVPNLFAHKNGPFSTLVMT 1547
Score = 113 bits (271), Expect = 5e-24
Identities = 71/213 (33%), Positives = 107/213 (50%), Gaps = 8/213 (3%)
Query: 412 LKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS- 470
L I + G+ +VG GCGKS++L + G V RS
Sbjct: 688 LSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSR 747
Query: 471 ---SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIG 527
S+ Q+P L T+ +NI GSP ++ + V + I LLP G T IG
Sbjct: 748 NRYSVAYAAQKPWLLNATVEENITFGSP-FNKQRYKAVTDACSLQPDIDLLPFGDQTEIG 806
Query: 528 ERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPH-SERQVQAALDR--ASVGRTT 584
ERG +LSGGQ+QRI +AR+L + ++ LD+ SALD H S+ +Q + + RT
Sbjct: 807 ERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTL 866
Query: 585 ITVSHRLSTIVNADRIICMDQGVIVEQGTHEDL 617
+ V+H+L + +AD II M G ++ +GT +D+
Sbjct: 867 VLVTHKLQYLTHADWIIAMKDGSVLREGTLKDI 899
Score = 70.1 bits (164), Expect = 5e-11
Identities = 107/457 (23%), Positives = 180/457 (39%), Gaps = 34/457 (7%)
Query: 783 YSVLFVVIAAVAGISMCL-QSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGA 841
Y V I AGI +CL S T GL L H ++ I FFD T +G
Sbjct: 1034 YYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFD--TTPLGL 1091
Query: 842 ICARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLMVGSIW 901
I R S DT + + + + + + + + ISY + LVA LPL V +
Sbjct: 1092 ILNRFSADTNIIDQHIPPTLESLTRS-TLLCLSAIGMISYATPVFLVA--LLPLGVAFYF 1148
Query: 902 LEG---IISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALKTACVA 958
++ + S+ Q + + +E + T+++ ET F Q+ + T +A
Sbjct: 1149 IQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIA 1208
Query: 959 VAYKT---RWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEYKLVLLVNEAIMYGAYM 1015
+ + RW L V ++ C ++ + L + A+ Y
Sbjct: 1209 YLFLSAANRW------LEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITNY- 1261
Query: 1016 LGQSLVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKD----WVASGNFSMRDVEF 1071
L + L ++ S + + + N G D W G + D+
Sbjct: 1262 LNWVVRNLADLEVQMGAVKKVNSFLTMESE--NYEGTMDPSQVPEHWPQEGEIKIHDLCV 1319
Query: 1072 CYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIR 1131
Y + VLK + ++ G+ + + G +G GKS++ F R D G I +D DI
Sbjct: 1320 RYENN-LKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDI- 1377
Query: 1132 SALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSL 1191
S L + LR +L ++ Q+P+L S+ N+ D K T + A + A + + + SL
Sbjct: 1378 SKLPLHTLRSRLSIILQDPILFSGSIRFNL---DPECKCTDDRLWEALEIAQLKNMVKSL 1434
Query: 1192 P----KAVTEALEKAAKGRTCITIAHRLSTVKDADLI 1224
P VTE E + G+ + R K + LI
Sbjct: 1435 PGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILI 1471
Score = 40.3 bits (90), Expect = 0.043
Identities = 25/86 (29%), Positives = 41/86 (47%), Gaps = 3/86 (3%)
Query: 1082 LKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDN-RDIRSALTIPRLR 1140
L ID+++ G+ +VG GCGKS++L G + N + + R R
Sbjct: 688 LSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSR 747
Query: 1141 RQLGV--VQQEPVLLDRSLAENIAYG 1164
+ V Q+P LL+ ++ ENI +G
Sbjct: 748 NRYSVAYAAQKPWLLNATVEENITFG 773
Score = 38.3 bits (85), Expect = 0.17
Identities = 41/139 (29%), Positives = 61/139 (43%), Gaps = 14/139 (10%)
Query: 1120 SGFIELDNRDIRSALTIPRLRRQLGVVQQEPVL--LDRSLAENIAYGDNNRKVTMHEIVA 1177
SG I N D T RL L + Q + ++ L L + G N V ++
Sbjct: 1400 SGSIRF-NLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFC 1458
Query: 1178 AAKAANIHSFIV-------SLPKAVTEALEK----AAKGRTCITIAHRLSTVKDADLICV 1226
A+A S I+ S+ A L+K A RT +T+AHR+S++ DA L+ V
Sbjct: 1459 LARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTMAHRVSSIMDAGLVLV 1518
Query: 1227 IDKGKIVERGTHAELVSMK 1245
+G +VE T L + K
Sbjct: 1519 FSEGILVECDTVPNLFAHK 1537
>U83661-1|AAB71758.2| 1437|Homo sapiens multidrug resistance protein 5
protein.
Length = 1437
Score = 134 bits (324), Expect = 2e-30
Identities = 132/528 (25%), Positives = 230/528 (43%), Gaps = 21/528 (3%)
Query: 114 ISIGVSLVFCVLSFSLISWSALRQITRIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENL 173
+S+ V L+ + + LR +R+ R +LR M ++DT + ++ S+++
Sbjct: 920 LSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFSKDM 979
Query: 174 MSIKEGMGEKLAV-VSN--LVGTSVICLCTAFPLGWQLTLACAAVMPFSVITSIALSNYQ 230
+ + + + + N LV V + FP W L V+ FSV+ ++ +
Sbjct: 980 DEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFP--WFLVAVGPLVILFSVLHIVSRVLIR 1037
Query: 231 TKSSIREMESYSLAGKQAEEILKSVRTIVAFGGENKEVERYRRLLEPAEEFGRKRGLFTG 290
+ + I + + TI A+ + + RY+ LL+ + LFT
Sbjct: 1038 ELKRLDNITQSPFLSHITSSI-QGLATIHAYNKGQEFLHRYQELLDDNQA---PFFLFTC 1093
Query: 291 LGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVYSILFSVYMATQSITFC 350
W L L+ I + T + + P A +I ++V + T F
Sbjct: 1094 ---AMRW-LAVRLDLISIALITTTGLMIVLMHGQIP--PAYAGLAISYAVQL-TGLFQFT 1146
Query: 351 VPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPRR---VVGDILLEDVEFCYPSRP 407
V I H I+ + K P G++ E+ E Y
Sbjct: 1147 VRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENL 1206
Query: 408 EVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSW 467
+ VLK S +KP E + +VG +G GKS++ L RL + G + +
Sbjct: 1207 PL-VLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLAD 1265
Query: 468 LRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIG 527
LRS L ++ QEPVLF GT+ N+ + + T ++I E + + I+ LP ++ +
Sbjct: 1266 LRSKLSIIPQEPVLFSGTVRSNLDPFN-QYTEDQIWDALERTHMKECIAQLPLKLESEVM 1324
Query: 528 ERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITV 587
E G + S G++Q + IAR+LLR +L+LDEAT+A+D ++ +Q + A T +T+
Sbjct: 1325 ENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTI 1384
Query: 588 SHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENK 635
+HRL T++ +DRI+ + QG +VE T L+ + ENK
Sbjct: 1385 AHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAMFAAAENK 1432
Score = 114 bits (274), Expect = 2e-24
Identities = 67/216 (31%), Positives = 112/216 (51%), Gaps = 15/216 (6%)
Query: 410 KVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLR 469
+ L + ++ G+ V + GS G GK++++ + GS+ +
Sbjct: 576 RTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIA-------------IS 622
Query: 470 SSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGER 529
+ V Q+ + T+ DNI G E E V +++LP+ T IGER
Sbjct: 623 GTFAYVAQQAWILNATLRDNILFGK-EYDEERYNSVLNSCCLRPDLAILPSSDLTEIGER 681
Query: 530 GASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVS 588
GA+LSGGQ+QRI++AR+L + ++ +LD+ SALD H + +A+ + +T + V+
Sbjct: 682 GANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVT 741
Query: 589 HRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFY 624
H+L +V+ D +I M +G I E+GTHE+LM G Y
Sbjct: 742 HQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDY 777
Score = 84.6 bits (200), Expect = 2e-15
Identities = 98/430 (22%), Positives = 178/430 (41%), Gaps = 30/430 (6%)
Query: 783 YSVLFVVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAI 842
Y+ ++ + AV I ++ F L+ ++RL + F +L+ + FFD T G I
Sbjct: 914 YASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFD--TTPTGRI 971
Query: 843 CARLSGDTAEVQGATGLRIGLILQGISSVV--VGFLLAISYNWKLTLVATVFLPLMVGSI 900
R S D EV + + +Q + V VG + + + W L V + + V I
Sbjct: 972 LNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGV-FPWFLVAVGPLVILFSVLHI 1030
Query: 901 WLEGIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDAL---KTACV 957
+I + ++D + I T ++ + T+ + FL ++Q+ L +
Sbjct: 1031 VSRVLIRELKRLDNITQSPFLSHI-TSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFF 1089
Query: 958 AVAYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVA-YGEMEYKLVLLVNEAIMYGAYML 1016
RW L V + ++ T G ++V +G++ L AI Y +
Sbjct: 1090 LFTCAMRW------LAVRLDLISIALITTTGLMIVLMHGQIPPAYAGL---AISYAVQLT 1140
Query: 1017 G--QSLVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKK---DWVASGNFSMRDVEF 1071
G Q V S A+ ++ + + +K+K DW G + + E
Sbjct: 1141 GLFQFTVRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEM 1200
Query: 1072 CYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIR 1131
Y VLK + ++ + I +VG +G GKS++ R + G I++D I
Sbjct: 1201 RYREN-LPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRI- 1258
Query: 1132 SALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSL 1191
S + + LR +L ++ QEPVL ++ N+ D + T +I A + ++ I L
Sbjct: 1259 SDIGLADLRSKLSIIPQEPVLFSGTVRSNL---DPFNQYTEDQIWDALERTHMKECIAQL 1315
Query: 1192 P-KAVTEALE 1200
P K +E +E
Sbjct: 1316 PLKLESEVME 1325
Score = 45.6 bits (103), Expect = 0.001
Identities = 19/51 (37%), Positives = 31/51 (60%)
Query: 1198 ALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHY 1248
A+ K K +T + + H+L + D D + + +G I ERGTH EL+++ G Y
Sbjct: 727 AIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDY 777
Score = 41.5 bits (93), Expect = 0.018
Identities = 35/109 (32%), Positives = 56/109 (51%), Gaps = 15/109 (13%)
Query: 1146 VQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKA----------- 1194
+ Q P+ L+ + EN GDN V +++ A+A H I+ L +A
Sbjct: 1312 IAQLPLKLESEVMEN---GDNF-SVGERQLLCIARALLRHCKILILDEATAAMDTETDLL 1367
Query: 1195 VTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVS 1243
+ E + +A T +TIAHRL TV +D I V+ +G++VE T + L+S
Sbjct: 1368 IQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLS 1416
Score = 33.9 bits (74), Expect = 3.7
Identities = 13/31 (41%), Positives = 22/31 (70%)
Query: 1079 QRVLKGIDLKMEAGKTIALVGSSGCGKSTIL 1109
QR L IDL+++ GK + + GS G GK++++
Sbjct: 575 QRTLHSIDLEIQEGKLVGICGSVGSGKTSLI 605
>AY032599-1|AAK39642.1| 1463|Homo sapiens multidrug
resistance-associated protein 7 protein.
Length = 1463
Score = 134 bits (324), Expect = 2e-30
Identities = 75/220 (34%), Positives = 124/220 (56%), Gaps = 5/220 (2%)
Query: 392 GDILLEDVEFCY-PSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQA 450
G + +DV Y P P L G + V+PGE V +VG +G GKS++L +L RL +P +
Sbjct: 1215 GGVEFQDVVLAYRPGLPNA--LDGVTFCVQPGEKVGIVGRTGSGKSSLLLVLFRLLEPSS 1272
Query: 451 GSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAY 510
G V + LRS L ++ QEP LF GT+ +N+ R Q + +
Sbjct: 1273 GRVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCHL 1332
Query: 511 AHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQ 570
+ S+ G D +GE G SLS GQ+Q + +AR+LL + +L +DEAT+++D +++
Sbjct: 1333 SEVITSM--GGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQL 1390
Query: 571 VQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVE 610
+Q + + +T +T++HRL+TI+N+DR++ + +VE
Sbjct: 1391 LQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAERVVE 1430
Score = 89.4 bits (212), Expect = 7e-17
Identities = 61/203 (30%), Positives = 96/203 (47%), Gaps = 12/203 (5%)
Query: 417 IHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVG 476
+ VK G V VG GCGKS++L + G V L G+
Sbjct: 592 LEVKKGMLVGTVGKVGCGKSSLLAAIAGELHRLRGHVAVRG----------LSKGFGLAT 641
Query: 477 QEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGG 536
QEP + TI DNI G + + V E +D +S+LP G T +GE+G +LSGG
Sbjct: 642 QEPWIQFATIRDNILFGKT-FDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGG 700
Query: 537 QKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTT-ITVSHRLSTIV 595
Q+ RIA+AR++ +E + LLD+ +A+D + TT + +HR +
Sbjct: 701 QRARIALARAVYQEKELYLLDDPLAAVDADVANHPLHRCILGMLSYTTRLLCTHRTEYLE 760
Query: 596 NADRIICMDQGVIVEQGTHEDLM 618
AD ++ M+ G ++ G +++
Sbjct: 761 RADAVLLMEAGRLIRAGPPPEIL 783
Score = 70.5 bits (165), Expect = 3e-11
Identities = 48/182 (26%), Positives = 88/182 (48%), Gaps = 7/182 (3%)
Query: 1058 WVASGNFSMRDVEFCYPTRPS-QRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFY 1116
W+ G +DV Y RP L G+ ++ G+ + +VG +G GKS++L + R
Sbjct: 1211 WLTQGGVEFQDVVLAY--RPGLPNALDGVTFCVQPGEKVGIVGRTGSGKSSLLLVLFRLL 1268
Query: 1117 DPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIV 1176
+P SG + LD D S L + +LR QL ++ QEP L ++ EN+ ++ + + +
Sbjct: 1269 EPSSGRVLLDGVD-TSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQAL 1327
Query: 1177 AAAKAANIHSFIVSLPKAVTEALEKAAKG-RTCITIAHRLSTVKDADLICVIDKGKIVER 1235
+ + + + L + E + G R + +A L T DA ++C+ + V++
Sbjct: 1328 KQCHLSEVITSMGGLDGELGEGGRSLSLGQRQLLCLARALLT--DAKILCIDEATASVDQ 1385
Query: 1236 GT 1237
T
Sbjct: 1386 KT 1387
Score = 34.3 bits (75), Expect = 2.8
Identities = 25/96 (26%), Positives = 45/96 (46%), Gaps = 7/96 (7%)
Query: 1153 LDRSLAE---NIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAVTEALE----KAAKG 1205
LD L E +++ G ++ AK I S+ + + L+ K
Sbjct: 1342 LDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRFAN 1401
Query: 1206 RTCITIAHRLSTVKDADLICVIDKGKIVERGTHAEL 1241
+T +TIAHRL+T+ ++D + V+ ++VE + A L
Sbjct: 1402 KTVLTIAHRLNTILNSDRVLVLQAERVVELDSPATL 1437
>AF146074-1|AAD37716.1| 1437|Homo sapiens ABC protein protein.
Length = 1437
Score = 134 bits (324), Expect = 2e-30
Identities = 132/528 (25%), Positives = 230/528 (43%), Gaps = 21/528 (3%)
Query: 114 ISIGVSLVFCVLSFSLISWSALRQITRIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENL 173
+S+ V L+ + + LR +R+ R +LR M ++DT + ++ S+++
Sbjct: 920 LSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFSKDM 979
Query: 174 MSIKEGMGEKLAV-VSN--LVGTSVICLCTAFPLGWQLTLACAAVMPFSVITSIALSNYQ 230
+ + + + + N LV V + FP W L V+ FSV+ ++ +
Sbjct: 980 DEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFP--WFLVAVGPLVILFSVLHIVSRVLIR 1037
Query: 231 TKSSIREMESYSLAGKQAEEILKSVRTIVAFGGENKEVERYRRLLEPAEEFGRKRGLFTG 290
+ + I + + TI A+ + + RY+ LL+ + LFT
Sbjct: 1038 ELKRLDNITQSPFLSHITSSI-QGLATIHAYNKGQEFLHRYQELLDDNQA---PFFLFTC 1093
Query: 291 LGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVYSILFSVYMATQSITFC 350
W L L+ I + T + + P A +I ++V + T F
Sbjct: 1094 ---AMRW-LAVRLDLISIALITTTGLMIVLMHGQIP--PAYAGLAISYAVQL-TGLFQFT 1146
Query: 351 VPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPRR---VVGDILLEDVEFCYPSRP 407
V I H I+ + K P G++ E+ E Y
Sbjct: 1147 VRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENL 1206
Query: 408 EVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSW 467
+ VLK S +KP E + +VG +G GKS++ L RL + G + +
Sbjct: 1207 PL-VLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLAD 1265
Query: 468 LRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIG 527
LRS L ++ QEPVLF GT+ N+ + + T ++I E + + I+ LP ++ +
Sbjct: 1266 LRSKLSIIPQEPVLFSGTVRSNLDPFN-QYTEDQIWDALERTHMKECIAQLPLKLESEVM 1324
Query: 528 ERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITV 587
E G + S G++Q + IAR+LLR +L+LDEAT+A+D ++ +Q + A T +T+
Sbjct: 1325 ENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTI 1384
Query: 588 SHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENK 635
+HRL T++ +DRI+ + QG +VE T L+ + ENK
Sbjct: 1385 AHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAMFAAAENK 1432
Score = 113 bits (273), Expect = 3e-24
Identities = 67/216 (31%), Positives = 112/216 (51%), Gaps = 15/216 (6%)
Query: 410 KVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLR 469
+ L + ++ G+ V + GS G GK++++ + GS+ +
Sbjct: 576 RTLHSVDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIA-------------IS 622
Query: 470 SSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGER 529
+ V Q+ + T+ DNI G E E V +++LP+ T IGER
Sbjct: 623 GTFAYVAQQAWILNATLRDNILFGK-EYDEERYNSVLNSCCLRPDLAILPSSDLTEIGER 681
Query: 530 GASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVS 588
GA+LSGGQ+QRI++AR+L + ++ +LD+ SALD H + +A+ + +T + V+
Sbjct: 682 GANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVT 741
Query: 589 HRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFY 624
H+L +V+ D +I M +G I E+GTHE+LM G Y
Sbjct: 742 HQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDY 777
Score = 84.6 bits (200), Expect = 2e-15
Identities = 98/430 (22%), Positives = 178/430 (41%), Gaps = 30/430 (6%)
Query: 783 YSVLFVVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAI 842
Y+ ++ + AV I ++ F L+ ++RL + F +L+ + FFD T G I
Sbjct: 914 YASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFD--TTPTGRI 971
Query: 843 CARLSGDTAEVQGATGLRIGLILQGISSVV--VGFLLAISYNWKLTLVATVFLPLMVGSI 900
R S D EV + + +Q + V VG + + + W L V + + V I
Sbjct: 972 LNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGV-FPWFLVAVGPLVILFSVLHI 1030
Query: 901 WLEGIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDAL---KTACV 957
+I + ++D + I T ++ + T+ + FL ++Q+ L +
Sbjct: 1031 VSRVLIRELKRLDNITQSPFLSHI-TSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFF 1089
Query: 958 AVAYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVA-YGEMEYKLVLLVNEAIMYGAYML 1016
RW L V + ++ T G ++V +G++ L AI Y +
Sbjct: 1090 LFTCAMRW------LAVRLDLISIALITTTGLMIVLMHGQIPPAYAGL---AISYAVQLT 1140
Query: 1017 G--QSLVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKK---DWVASGNFSMRDVEF 1071
G Q V S A+ ++ + + +K+K DW G + + E
Sbjct: 1141 GLFQFTVRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEM 1200
Query: 1072 CYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIR 1131
Y VLK + ++ + I +VG +G GKS++ R + G I++D I
Sbjct: 1201 RYREN-LPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRI- 1258
Query: 1132 SALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSL 1191
S + + LR +L ++ QEPVL ++ N+ D + T +I A + ++ I L
Sbjct: 1259 SDIGLADLRSKLSIIPQEPVLFSGTVRSNL---DPFNQYTEDQIWDALERTHMKECIAQL 1315
Query: 1192 P-KAVTEALE 1200
P K +E +E
Sbjct: 1316 PLKLESEVME 1325
Score = 45.6 bits (103), Expect = 0.001
Identities = 19/51 (37%), Positives = 31/51 (60%)
Query: 1198 ALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHY 1248
A+ K K +T + + H+L + D D + + +G I ERGTH EL+++ G Y
Sbjct: 727 AIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDY 777
Score = 41.5 bits (93), Expect = 0.018
Identities = 35/109 (32%), Positives = 56/109 (51%), Gaps = 15/109 (13%)
Query: 1146 VQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKA----------- 1194
+ Q P+ L+ + EN GDN V +++ A+A H I+ L +A
Sbjct: 1312 IAQLPLKLESEVMEN---GDNF-SVGERQLLCIARALLRHCKILILDEATAAMDTETDLL 1367
Query: 1195 VTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVS 1243
+ E + +A T +TIAHRL TV +D I V+ +G++VE T + L+S
Sbjct: 1368 IQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLS 1416
Score = 33.5 bits (73), Expect = 4.9
Identities = 12/31 (38%), Positives = 22/31 (70%)
Query: 1079 QRVLKGIDLKMEAGKTIALVGSSGCGKSTIL 1109
QR L +DL+++ GK + + GS G GK++++
Sbjct: 575 QRTLHSVDLEIQEGKLVGICGSVGSGKTSLI 605
>AF104942-1|AAD04169.1| 1437|Homo sapiens ABC transporter MOAT-C
protein.
Length = 1437
Score = 134 bits (324), Expect = 2e-30
Identities = 132/528 (25%), Positives = 230/528 (43%), Gaps = 21/528 (3%)
Query: 114 ISIGVSLVFCVLSFSLISWSALRQITRIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENL 173
+S+ V L+ + + LR +R+ R +LR M ++DT + ++ S+++
Sbjct: 920 LSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFSKDM 979
Query: 174 MSIKEGMGEKLAV-VSN--LVGTSVICLCTAFPLGWQLTLACAAVMPFSVITSIALSNYQ 230
+ + + + + N LV V + FP W L V+ FSV+ ++ +
Sbjct: 980 DEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFP--WFLVAVGPLVILFSVLHIVSRVLIR 1037
Query: 231 TKSSIREMESYSLAGKQAEEILKSVRTIVAFGGENKEVERYRRLLEPAEEFGRKRGLFTG 290
+ + I + + TI A+ + + RY+ LL+ + LFT
Sbjct: 1038 ELKRLDNITQSPFLSHITSSI-QGLATIHAYNKGQEFLHRYQELLDDNQA---PFFLFTC 1093
Query: 291 LGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVYSILFSVYMATQSITFC 350
W L L+ I + T + + P A +I ++V + T F
Sbjct: 1094 ---AMRW-LAVRLDLISIALITTTGLMIVLMHGQIP--PAYAGLAISYAVQL-TGLFQFT 1146
Query: 351 VPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPRR---VVGDILLEDVEFCYPSRP 407
V I H I+ + K P G++ E+ E Y
Sbjct: 1147 VRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENL 1206
Query: 408 EVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSW 467
+ VLK S +KP E + +VG +G GKS++ L RL + G + +
Sbjct: 1207 PL-VLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLAD 1265
Query: 468 LRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIG 527
LRS L ++ QEPVLF GT+ N+ + + T ++I E + + I+ LP ++ +
Sbjct: 1266 LRSKLSIIPQEPVLFSGTVRSNLDPFN-QYTEDQIWDALERTHMKECIAQLPLKLESEVM 1324
Query: 528 ERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITV 587
E G + S G++Q + IAR+LLR +L+LDEAT+A+D ++ +Q + A T +T+
Sbjct: 1325 ENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTI 1384
Query: 588 SHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENK 635
+HRL T++ +DRI+ + QG +VE T L+ + ENK
Sbjct: 1385 AHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAMFAAAENK 1432
Score = 114 bits (274), Expect = 2e-24
Identities = 67/216 (31%), Positives = 112/216 (51%), Gaps = 15/216 (6%)
Query: 410 KVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLR 469
+ L + ++ G+ V + GS G GK++++ + GS+ +
Sbjct: 576 RTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIA-------------IS 622
Query: 470 SSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGER 529
+ V Q+ + T+ DNI G E E V +++LP+ T IGER
Sbjct: 623 GTFAYVAQQAWILNATLRDNILFGK-EYDEERYNSVLNSCCLRPDLAILPSSDLTEIGER 681
Query: 530 GASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVS 588
GA+LSGGQ+QRI++AR+L + ++ +LD+ SALD H + +A+ + +T + V+
Sbjct: 682 GANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVT 741
Query: 589 HRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFY 624
H+L +V+ D +I M +G I E+GTHE+LM G Y
Sbjct: 742 HQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDY 777
Score = 84.6 bits (200), Expect = 2e-15
Identities = 98/430 (22%), Positives = 178/430 (41%), Gaps = 30/430 (6%)
Query: 783 YSVLFVVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAI 842
Y+ ++ + AV I ++ F L+ ++RL + F +L+ + FFD T G I
Sbjct: 914 YASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFD--TTPTGRI 971
Query: 843 CARLSGDTAEVQGATGLRIGLILQGISSVV--VGFLLAISYNWKLTLVATVFLPLMVGSI 900
R S D EV + + +Q + V VG + + + W L V + + V I
Sbjct: 972 LNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGV-FPWFLVAVGPLVILFSVLHI 1030
Query: 901 WLEGIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDAL---KTACV 957
+I + ++D + I T ++ + T+ + FL ++Q+ L +
Sbjct: 1031 VSRVLIRELKRLDNITQSPFLSHI-TSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFF 1089
Query: 958 AVAYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVA-YGEMEYKLVLLVNEAIMYGAYML 1016
RW L V + ++ T G ++V +G++ L AI Y +
Sbjct: 1090 LFTCAMRW------LAVRLDLISIALITTTGLMIVLMHGQIPPAYAGL---AISYAVQLT 1140
Query: 1017 G--QSLVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKK---DWVASGNFSMRDVEF 1071
G Q V S A+ ++ + + +K+K DW G + + E
Sbjct: 1141 GLFQFTVRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEM 1200
Query: 1072 CYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIR 1131
Y VLK + ++ + I +VG +G GKS++ R + G I++D I
Sbjct: 1201 RYREN-LPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRI- 1258
Query: 1132 SALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSL 1191
S + + LR +L ++ QEPVL ++ N+ D + T +I A + ++ I L
Sbjct: 1259 SDIGLADLRSKLSIIPQEPVLFSGTVRSNL---DPFNQYTEDQIWDALERTHMKECIAQL 1315
Query: 1192 P-KAVTEALE 1200
P K +E +E
Sbjct: 1316 PLKLESEVME 1325
Score = 45.6 bits (103), Expect = 0.001
Identities = 19/51 (37%), Positives = 31/51 (60%)
Query: 1198 ALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHY 1248
A+ K K +T + + H+L + D D + + +G I ERGTH EL+++ G Y
Sbjct: 727 AIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDY 777
Score = 41.5 bits (93), Expect = 0.018
Identities = 35/109 (32%), Positives = 56/109 (51%), Gaps = 15/109 (13%)
Query: 1146 VQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKA----------- 1194
+ Q P+ L+ + EN GDN V +++ A+A H I+ L +A
Sbjct: 1312 IAQLPLKLESEVMEN---GDNF-SVGERQLLCIARALLRHCKILILDEATAAMDTETDLL 1367
Query: 1195 VTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVS 1243
+ E + +A T +TIAHRL TV +D I V+ +G++VE T + L+S
Sbjct: 1368 IQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLS 1416
Score = 33.9 bits (74), Expect = 3.7
Identities = 13/31 (41%), Positives = 22/31 (70%)
Query: 1079 QRVLKGIDLKMEAGKTIALVGSSGCGKSTIL 1109
QR L IDL+++ GK + + GS G GK++++
Sbjct: 575 QRTLHSIDLEIQEGKLVGICGSVGSGKTSLI 605
>AB209454-1|BAD92691.1| 1430|Homo sapiens Multidrug
resistance-associated protein 5 variant protein.
Length = 1430
Score = 134 bits (324), Expect = 2e-30
Identities = 132/528 (25%), Positives = 230/528 (43%), Gaps = 21/528 (3%)
Query: 114 ISIGVSLVFCVLSFSLISWSALRQITRIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENL 173
+S+ V L+ + + LR +R+ R +LR M ++DT + ++ S+++
Sbjct: 913 LSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFSKDM 972
Query: 174 MSIKEGMGEKLAV-VSN--LVGTSVICLCTAFPLGWQLTLACAAVMPFSVITSIALSNYQ 230
+ + + + + N LV V + FP W L V+ FSV+ ++ +
Sbjct: 973 DEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFP--WFLVAVGPLVILFSVLHIVSRVLIR 1030
Query: 231 TKSSIREMESYSLAGKQAEEILKSVRTIVAFGGENKEVERYRRLLEPAEEFGRKRGLFTG 290
+ + I + + TI A+ + + RY+ LL+ + LFT
Sbjct: 1031 ELKRLDNITQSPFLSHITSSI-QGLATIHAYNKGQEFLHRYQELLDDNQA---PFFLFTC 1086
Query: 291 LGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVYSILFSVYMATQSITFC 350
W L L+ I + T + + P A +I ++V + T F
Sbjct: 1087 ---AMRW-LAVRLDLISIALITTTGLMIVLMHGQIP--PAYAGLAISYAVQL-TGLFQFT 1139
Query: 351 VPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPRR---VVGDILLEDVEFCYPSRP 407
V I H I+ + K P G++ E+ E Y
Sbjct: 1140 VRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENL 1199
Query: 408 EVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSW 467
+ VLK S +KP E + +VG +G GKS++ L RL + G + +
Sbjct: 1200 PL-VLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLAD 1258
Query: 468 LRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIG 527
LRS L ++ QEPVLF GT+ N+ + + T ++I E + + I+ LP ++ +
Sbjct: 1259 LRSKLSIIPQEPVLFSGTVRSNLDPFN-QYTEDQIWDALERTHMKECIAQLPLKLESEVM 1317
Query: 528 ERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITV 587
E G + S G++Q + IAR+LLR +L+LDEAT+A+D ++ +Q + A T +T+
Sbjct: 1318 ENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTI 1377
Query: 588 SHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENK 635
+HRL T++ +DRI+ + QG +VE T L+ + ENK
Sbjct: 1378 AHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAMFAAAENK 1425
Score = 114 bits (274), Expect = 2e-24
Identities = 67/216 (31%), Positives = 112/216 (51%), Gaps = 15/216 (6%)
Query: 410 KVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLR 469
+ L + ++ G+ V + GS G GK++++ + GS+ +
Sbjct: 569 RTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIA-------------IS 615
Query: 470 SSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGER 529
+ V Q+ + T+ DNI G E E V +++LP+ T IGER
Sbjct: 616 GTFAYVAQQAWILNATLRDNILFGK-EYDEERYNSVLNSCCLRPDLAILPSSDLTEIGER 674
Query: 530 GASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVS 588
GA+LSGGQ+QRI++AR+L + ++ +LD+ SALD H + +A+ + +T + V+
Sbjct: 675 GANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVT 734
Query: 589 HRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFY 624
H+L +V+ D +I M +G I E+GTHE+LM G Y
Sbjct: 735 HQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDY 770
Score = 84.6 bits (200), Expect = 2e-15
Identities = 98/430 (22%), Positives = 178/430 (41%), Gaps = 30/430 (6%)
Query: 783 YSVLFVVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAI 842
Y+ ++ + AV I ++ F L+ ++RL + F +L+ + FFD T G I
Sbjct: 907 YASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFD--TTPTGRI 964
Query: 843 CARLSGDTAEVQGATGLRIGLILQGISSVV--VGFLLAISYNWKLTLVATVFLPLMVGSI 900
R S D EV + + +Q + V VG + + + W L V + + V I
Sbjct: 965 LNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGV-FPWFLVAVGPLVILFSVLHI 1023
Query: 901 WLEGIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDAL---KTACV 957
+I + ++D + I T ++ + T+ + FL ++Q+ L +
Sbjct: 1024 VSRVLIRELKRLDNITQSPFLSHI-TSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFF 1082
Query: 958 AVAYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVA-YGEMEYKLVLLVNEAIMYGAYML 1016
RW L V + ++ T G ++V +G++ L AI Y +
Sbjct: 1083 LFTCAMRW------LAVRLDLISIALITTTGLMIVLMHGQIPPAYAGL---AISYAVQLT 1133
Query: 1017 G--QSLVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKK---DWVASGNFSMRDVEF 1071
G Q V S A+ ++ + + +K+K DW G + + E
Sbjct: 1134 GLFQFTVRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEM 1193
Query: 1072 CYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIR 1131
Y VLK + ++ + I +VG +G GKS++ R + G I++D I
Sbjct: 1194 RYREN-LPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRI- 1251
Query: 1132 SALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSL 1191
S + + LR +L ++ QEPVL ++ N+ D + T +I A + ++ I L
Sbjct: 1252 SDIGLADLRSKLSIIPQEPVLFSGTVRSNL---DPFNQYTEDQIWDALERTHMKECIAQL 1308
Query: 1192 P-KAVTEALE 1200
P K +E +E
Sbjct: 1309 PLKLESEVME 1318
Score = 45.6 bits (103), Expect = 0.001
Identities = 19/51 (37%), Positives = 31/51 (60%)
Query: 1198 ALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHY 1248
A+ K K +T + + H+L + D D + + +G I ERGTH EL+++ G Y
Sbjct: 720 AIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDY 770
Score = 41.5 bits (93), Expect = 0.018
Identities = 35/109 (32%), Positives = 56/109 (51%), Gaps = 15/109 (13%)
Query: 1146 VQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKA----------- 1194
+ Q P+ L+ + EN GDN V +++ A+A H I+ L +A
Sbjct: 1305 IAQLPLKLESEVMEN---GDNF-SVGERQLLCIARALLRHCKILILDEATAAMDTETDLL 1360
Query: 1195 VTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVS 1243
+ E + +A T +TIAHRL TV +D I V+ +G++VE T + L+S
Sbjct: 1361 IQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLS 1409
Score = 33.9 bits (74), Expect = 3.7
Identities = 13/31 (41%), Positives = 22/31 (70%)
Query: 1079 QRVLKGIDLKMEAGKTIALVGSSGCGKSTIL 1109
QR L IDL+++ GK + + GS G GK++++
Sbjct: 568 QRTLHSIDLEIQEGKLVGICGSVGSGKTSLI 598
>AY207008-1|AAO37649.1| 1325|Homo sapiens ATP-binding cassette
transporter C4 protein.
Length = 1325
Score = 133 bits (321), Expect = 4e-30
Identities = 78/239 (32%), Positives = 134/239 (56%), Gaps = 6/239 (2%)
Query: 392 GDILLEDVEFCY-PSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQA 450
G I+ ++V F Y P P VLK + +K E V +VG +G GKS+++ L RL +P+
Sbjct: 1039 GVIIFDNVNFMYSPGGP--LVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPE- 1095
Query: 451 GSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAY 510
G + LR + ++ QEPVLF GT+ N+ + E T EE+ +
Sbjct: 1096 GKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFN-EHTDEELWNALQEVQ 1154
Query: 511 AHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQ 570
+ I LP DT + E G++ S GQ+Q + +AR++LR+ +L++DEAT+ +DP ++
Sbjct: 1155 LKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDEL 1214
Query: 571 VQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAK-GFYHKLV 628
+Q + T +T++HRL+TI+++D+I+ +D G + E L++ K ++K+V
Sbjct: 1215 IQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMV 1273
Score = 123 bits (296), Expect = 5e-27
Identities = 189/830 (22%), Positives = 349/830 (42%), Gaps = 88/830 (10%)
Query: 396 LEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXX 455
++D + E L+G S V+PGE +A+VG G GKS++L + P G V
Sbjct: 412 VQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVS- 470
Query: 456 XXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFI 515
+ + V Q+P +F GT+ NI G + +E ++V + +
Sbjct: 471 ------------VHGRIAYVSQQPWVFSGTLRSNILFGK-KYEKERYEKVIKACALKKDL 517
Query: 516 SLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAA 574
LL +G TVIG+RG +LSGGQK R+ +AR++ ++ + LLD+ SA+D R + +
Sbjct: 518 QLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELC 577
Query: 575 LDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNEN 634
+ + + TI V+H+L + A +I+ I++ G M KG Y + + +G
Sbjct: 578 ICQILHEKITILVTHQLQYLKAASQIL------ILKDGK----MVQKGTYTEFLKSG--- 624
Query: 635 KEPADIEPLIEEADGDGDNIEPTVPSRLDVRRR--SSKKVLRHHSIKKDHPDW-LTPRGS 691
D L+++ + + + +P VP +R R S V S + D L + +
Sbjct: 625 ---IDFGSLLKKDNEESE--QPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGALESQDT 679
Query: 692 ISSMVSIGLQNFVFNXXXXXXXXXXXXXTVKTVSDWQLLKLNAPEWPLITVGSIAAFLQG 751
+ V++ +N + L+ LN T +A LQ
Sbjct: 680 ENVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLN-------TAAQVAYVLQD 732
Query: 752 ACFPVFA----LLFGFSSGIFILDNRDDIIYLADLYSVLFVVIAAVAGISMCLQSTTFTS 807
+A +L +G + + D+ + +YS L V + GI+ L +
Sbjct: 733 WWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGL-TVATVLFGIARSLL-VFYVL 790
Query: 808 AGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQG 867
T L ++ F S+LK + FFD+ N +G I R S D + L +Q
Sbjct: 791 VNSSQT--LHNKMFESILKAPVLFFDR--NPIGRILNRFSKDIGHLDDLLPLTFLDFIQT 846
Query: 868 ISSVVVGFLLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATE 927
+ VV +A++ + +A +PL + I+L + ++ +R + + + +
Sbjct: 847 LLQVVGVVSVAVAV---IPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSH 903
Query: 928 AVVSIK---TVQSLGVETVFLQKF---QDALKTACVAVAYKTRWRGLVYGLGVYIPFMAY 981
S++ T+++ E + F QD A +RW + A
Sbjct: 904 LSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFA--------VRLDAI 955
Query: 982 CSATVYGAVLVAYGEMEYKLVL---LVNEAIMYGAYMLGQ---SLVYAPSLNTAKACGAR 1035
C+ V ++VA+G + L V A+ Y ++G + + + R
Sbjct: 956 CAMFV---IIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVER 1012
Query: 1036 ILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCY-PTRPSQRVLKGIDLKMEAGKT 1094
++ + + + W G +V F Y P P VLK + +++ +
Sbjct: 1013 VIEYTDLEKEAPWEYQKRPPPAWPHEGVIIFDNVNFMYSPGGPL--VLKHLTALIKSQEK 1070
Query: 1095 IALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLD 1154
+ +VG +G GKS+++ R +P+ G I +D + + + + + LR+++ ++ QEPVL
Sbjct: 1071 VGIVGRTGAGKSSLISALFRLSEPE-GKIWID-KILTTEIGLHDLRKKMSIIPQEPVLFT 1128
Query: 1155 RSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP-KAVTEALEKAA 1203
++ +N+ D + T E+ A + + I LP K TE E +
Sbjct: 1129 GTMRKNL---DPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGS 1175
Score = 38.7 bits (86), Expect = 0.13
Identities = 31/120 (25%), Positives = 56/120 (46%), Gaps = 10/120 (8%)
Query: 1122 FIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAE---NIAYGDNNRKVTMHEIVAA 1178
F E + ++ +AL +L+ ++ P +D LAE N + G I+
Sbjct: 1138 FNEHTDEELWNALQEVQLKE---TIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRK 1194
Query: 1179 AKAANIHSFIVSLPKAVTEALEKAAKGR----TCITIAHRLSTVKDADLICVIDKGKIVE 1234
+ I ++ E ++K + + T +TIAHRL+T+ D+D I V+D G++ E
Sbjct: 1195 NQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKE 1254
>AY196484-1|AAO49801.1| 1394|Homo sapiens ATP-binding cassette C5
splicing variant A protein.
Length = 1394
Score = 133 bits (321), Expect = 4e-30
Identities = 79/244 (32%), Positives = 130/244 (53%), Gaps = 2/244 (0%)
Query: 392 GDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAG 451
G++ E+ E Y + VLK S +KP E + +VG +G GKS++ L RL + G
Sbjct: 1148 GEVTFENAEMRYRENLPL-VLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGG 1206
Query: 452 SVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYA 511
+ + LRS L ++ QEPVLF GT+ N+ + + T ++I E +
Sbjct: 1207 CIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPFN-QYTEDQIWDALERTHM 1265
Query: 512 HDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV 571
+ I+ LP ++ + E G + S G++Q + IAR+LLR +L+LDEAT+A+D ++ +
Sbjct: 1266 KECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLI 1325
Query: 572 QAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTG 631
Q + A T +T++HRL T++ +DRI+ + QG +VE T L+ +
Sbjct: 1326 QETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAMFAA 1385
Query: 632 NENK 635
ENK
Sbjct: 1386 AENK 1389
Score = 114 bits (274), Expect = 2e-24
Identities = 67/216 (31%), Positives = 112/216 (51%), Gaps = 15/216 (6%)
Query: 410 KVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLR 469
+ L + ++ G+ V + GS G GK++++ + GS+ +
Sbjct: 576 RTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIA-------------IS 622
Query: 470 SSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGER 529
+ V Q+ + T+ DNI G E E V +++LP+ T IGER
Sbjct: 623 GTFAYVAQQAWILNATLRDNILFGK-EYDEERYNSVLNSCCLRPDLAILPSSDLTEIGER 681
Query: 530 GASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVS 588
GA+LSGGQ+QRI++AR+L + ++ +LD+ SALD H + +A+ + +T + V+
Sbjct: 682 GANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVT 741
Query: 589 HRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFY 624
H+L +V+ D +I M +G I E+GTHE+LM G Y
Sbjct: 742 HQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDY 777
Score = 53.6 bits (123), Expect = 4e-06
Identities = 40/145 (27%), Positives = 68/145 (46%), Gaps = 6/145 (4%)
Query: 1057 DWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFY 1116
DW G + + E Y VLK + ++ + I +VG +G GKS++ R
Sbjct: 1143 DWPQEGEVTFENAEMRYREN-LPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLV 1201
Query: 1117 DPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIV 1176
+ G I++D I S + + LR +L ++ QEPVL ++ N+ D + T +I
Sbjct: 1202 ELSGGCIKIDGVRI-SDIGLADLRSKLSIIPQEPVLFSGTVRSNL---DPFNQYTEDQIW 1257
Query: 1177 AAAKAANIHSFIVSLP-KAVTEALE 1200
A + ++ I LP K +E +E
Sbjct: 1258 DALERTHMKECIAQLPLKLESEVME 1282
Score = 45.6 bits (103), Expect = 0.001
Identities = 19/51 (37%), Positives = 31/51 (60%)
Query: 1198 ALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHY 1248
A+ K K +T + + H+L + D D + + +G I ERGTH EL+++ G Y
Sbjct: 727 AIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDY 777
Score = 41.5 bits (93), Expect = 0.018
Identities = 35/109 (32%), Positives = 56/109 (51%), Gaps = 15/109 (13%)
Query: 1146 VQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKA----------- 1194
+ Q P+ L+ + EN GDN V +++ A+A H I+ L +A
Sbjct: 1269 IAQLPLKLESEVMEN---GDNF-SVGERQLLCIARALLRHCKILILDEATAAMDTETDLL 1324
Query: 1195 VTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVS 1243
+ E + +A T +TIAHRL TV +D I V+ +G++VE T + L+S
Sbjct: 1325 IQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLS 1373
Score = 33.9 bits (74), Expect = 3.7
Identities = 13/31 (41%), Positives = 22/31 (70%)
Query: 1079 QRVLKGIDLKMEAGKTIALVGSSGCGKSTIL 1109
QR L IDL+++ GK + + GS G GK++++
Sbjct: 575 QRTLHSIDLEIQEGKLVGICGSVGSGKTSLI 605
>AY081219-1|AAL88745.1| 1325|Homo sapiens multidrug
resistance-associated protein protein.
Length = 1325
Score = 133 bits (321), Expect = 4e-30
Identities = 78/239 (32%), Positives = 134/239 (56%), Gaps = 6/239 (2%)
Query: 392 GDILLEDVEFCY-PSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQA 450
G I+ ++V F Y P P VLK + +K E V +VG +G GKS+++ L RL +P+
Sbjct: 1039 GVIIFDNVNFMYSPGGP--LVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPE- 1095
Query: 451 GSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAY 510
G + LR + ++ QEPVLF GT+ N+ + E T EE+ +
Sbjct: 1096 GKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFN-EHTDEELWNALQEVQ 1154
Query: 511 AHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQ 570
+ I LP DT + E G++ S GQ+Q + +AR++LR+ +L++DEAT+ +DP ++
Sbjct: 1155 LKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDEL 1214
Query: 571 VQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAK-GFYHKLV 628
+Q + T +T++HRL+TI+++D+I+ +D G + E L++ K ++K+V
Sbjct: 1215 IQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMV 1273
Score = 124 bits (298), Expect = 3e-27
Identities = 189/830 (22%), Positives = 349/830 (42%), Gaps = 88/830 (10%)
Query: 396 LEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXX 455
++D + E L+G S V+PGE +A+VG G GKS++L + P G V
Sbjct: 412 VQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVS- 470
Query: 456 XXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFI 515
+ + V Q+P +F GT+ NI G + +E ++V + +
Sbjct: 471 ------------VHGRIAYVSQQPWVFSGTLRSNILFGK-KYEKERYEKVIKACALKKDL 517
Query: 516 SLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAA 574
LL +G TVIG+RG +LSGGQK R+ +AR++ ++ + LLD+ SA+D R + +
Sbjct: 518 QLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELC 577
Query: 575 LDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNEN 634
+ + + TI V+H+L + A +I+ I++ G M KG Y + + +G
Sbjct: 578 ICQILHEKITILVTHQLQYLKAASQIL------ILKDGK----MVQKGTYTEFLKSG--- 624
Query: 635 KEPADIEPLIEEADGDGDNIEPTVPSRLDVRRR--SSKKVLRHHSIKKDHPDW-LTPRGS 691
D L+++ + + + +P VP +R R S V S + D L + +
Sbjct: 625 ---IDFGSLLKKDNEESE--QPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGALESQDT 679
Query: 692 ISSMVSIGLQNFVFNXXXXXXXXXXXXXTVKTVSDWQLLKLNAPEWPLITVGSIAAFLQG 751
+ V++ +N + L+ LN T +A LQ
Sbjct: 680 ENVPVTLSEENRSEGKVGFQAYKSYFRAGAHWIVFIFLILLN-------TAAQVAYVLQD 732
Query: 752 ACFPVFA----LLFGFSSGIFILDNRDDIIYLADLYSVLFVVIAAVAGISMCLQSTTFTS 807
+A +L +G + + D+ + +YS L V + GI+ L +
Sbjct: 733 WWLSYWANKQSMLNVTVNGGGNVTGKLDLNWYLGIYSGL-TVATVLFGIARSLL-VFYVL 790
Query: 808 AGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQG 867
T L ++ F S+LK + FFD+ N +G I R S D + L +Q
Sbjct: 791 VNSSQT--LHNKMFESILKAPVLFFDR--NPIGRILNRFSKDIGHLDDLLPLTFLDFIQT 846
Query: 868 ISSVVVGFLLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATE 927
+ VV +A++ + +A +PL + I+L + ++ +R + + + +
Sbjct: 847 LLQVVGVVSVAVAV---IPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLGSTTRSPVFSH 903
Query: 928 AVVSIK---TVQSLGVETVFLQKF---QDALKTACVAVAYKTRWRGLVYGLGVYIPFMAY 981
S++ T+++ E + F QD A +RW + A
Sbjct: 904 LSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFA--------VRLDAI 955
Query: 982 CSATVYGAVLVAYGEMEYKLVL---LVNEAIMYGAYMLGQ---SLVYAPSLNTAKACGAR 1035
C+ V ++VA+G + L V A+ Y ++G + + + R
Sbjct: 956 CAMFV---IIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVER 1012
Query: 1036 ILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCY-PTRPSQRVLKGIDLKMEAGKT 1094
++ + + + W G +V F Y P P VLK + +++ +
Sbjct: 1013 VIEYTDLEKEAPWEYQKRPPPAWPHEGVIIFDNVNFMYSPGGPL--VLKHLTALIKSQEK 1070
Query: 1095 IALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLD 1154
+ +VG +G GKS+++ R +P+ G I +D + + + + + LR+++ ++ QEPVL
Sbjct: 1071 VGIVGRTGAGKSSLISALFRLSEPE-GKIWID-KILTTEIGLHDLRKKMSIIPQEPVLFT 1128
Query: 1155 RSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP-KAVTEALEKAA 1203
++ +N+ D + T E+ A + + I LP K TE E +
Sbjct: 1129 GTMRKNL---DPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGS 1175
Score = 38.7 bits (86), Expect = 0.13
Identities = 31/120 (25%), Positives = 56/120 (46%), Gaps = 10/120 (8%)
Query: 1122 FIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAE---NIAYGDNNRKVTMHEIVAA 1178
F E + ++ +AL +L+ ++ P +D LAE N + G I+
Sbjct: 1138 FNEHTDEELWNALQEVQLKE---TIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRK 1194
Query: 1179 AKAANIHSFIVSLPKAVTEALEKAAKGR----TCITIAHRLSTVKDADLICVIDKGKIVE 1234
+ I ++ E ++K + + T +TIAHRL+T+ D+D I V+D G++ E
Sbjct: 1195 NQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKE 1254
>AY040220-1|AAK76740.1| 1359|Homo sapiens ATP-binding cassette
transporter sub-family C member 12 protein.
Length = 1359
Score = 133 bits (321), Expect = 4e-30
Identities = 71/219 (32%), Positives = 122/219 (55%), Gaps = 2/219 (0%)
Query: 392 GDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAG 451
G+I D + Y + VL +++++ G+ V +VG +G GKS++ L RL +P +G
Sbjct: 1118 GEITFRDYQMRYRDNTPL-VLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPASG 1176
Query: 452 SVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYA 511
++ LR+ L V+ Q+PVLF GT+ N+ T E + +V E +
Sbjct: 1177 TIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESH-TDEMLWQVLERTFM 1235
Query: 512 HDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV 571
D I LP + E G + S G++Q + +AR+LLR ++LLDEAT+++D ++ V
Sbjct: 1236 RDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATASMDSKTDTLV 1295
Query: 572 QAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVE 610
Q + A G T +T++HRL+T++N D ++ M+ G ++E
Sbjct: 1296 QNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIE 1334
Score = 119 bits (286), Expect = 8e-26
Identities = 74/230 (32%), Positives = 122/230 (53%), Gaps = 17/230 (7%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
VL S V+ G+ + + G+ G GKS++L L Q G V +
Sbjct: 495 VLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVA-------------VNG 541
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
+L V Q+ +F G + +NI G + + Q + +S LP G T IGERG
Sbjct: 542 TLAYVSQQAWIFHGNVRENILFGE-KYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERG 600
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVSH 589
+LSGGQ+QRI++AR++ + + LLD+ SA+D H + V + + + G+T + V+H
Sbjct: 601 LNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLVTH 660
Query: 590 RLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLV--TTGNENKEP 637
+L + + D +I ++ G I E+GTH++LM+ +G Y KL+ G + K+P
Sbjct: 661 QLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDP 710
Score = 68.1 bits (159), Expect = 2e-10
Identities = 91/361 (25%), Positives = 157/361 (43%), Gaps = 22/361 (6%)
Query: 805 FTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLI 864
FT L ++ L F +LK + FFD T G + R S D E+
Sbjct: 873 FTKTTLMASSSLHDTVFDKILKSPMSFFD--TTPTGRLMNRFSKDMDELDVRLPFHAENF 930
Query: 865 LQGISSVV-VGFLLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATA 923
LQ VV + +LA + L +VA+ L VG L I + Q E +E+ +
Sbjct: 931 LQQFFMVVFILVILAAVFPAVLLVVAS----LAVGFFILLRIFHRGVQ--ELKKVENVSR 984
Query: 924 IATEAVVSIKTVQSLGVETVFLQKFQDALKTACVAVAYKTRWRGLVYGLGVYIPFMAYCS 983
++ ++Q LG+ + +K + + + RW L + V + + +
Sbjct: 985 SPWFTHIT-SSMQGLGIIHAYGKK-ESCITYHLLYFNCALRWFAL--RMDVLMNILTF-- 1038
Query: 984 ATVYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYAPSLNTAKACGARILS--IIQ 1041
TV V +++ + L I+ + +L Q V + AK +L I
Sbjct: 1039 -TVALLVTLSFSSISTSSKGLSLSYIIQLSGLL-QVCVRTGTETQAKFTSVELLREYIST 1096
Query: 1042 RQPKIHNAVGVKD-KKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTIALVGS 1100
P+ + + V KDW + G + RD + Y + VL ++L +++G+T+ +VG
Sbjct: 1097 CVPECTHPLKVGTCPKDWPSCGEITFRDYQMRYRDN-TPLVLDSLNLNIQSGQTVGIVGR 1155
Query: 1101 SGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAEN 1160
+G GKS++ R +P SG I +D DI L++ LR +L V+ Q+PVL ++ N
Sbjct: 1156 TGSGKSSLGMALFRLVEPASGTIFIDEVDI-CILSLEDLRTKLTVIPQDPVLFVGTVRYN 1214
Query: 1161 I 1161
+
Sbjct: 1215 L 1215
Score = 49.2 bits (112), Expect = 9e-05
Identities = 17/55 (30%), Positives = 36/55 (65%)
Query: 1197 EALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRM 1251
E ++K +G+T + + H+L ++ D + +++ G+I E+GTH EL+ +G Y ++
Sbjct: 644 ECIKKTLRGKTVVLVTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKL 698
Score = 41.9 bits (94), Expect = 0.014
Identities = 18/40 (45%), Positives = 28/40 (70%)
Query: 1195 VTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVE 1234
V ++ A KG T +TIAHRL+TV + D + V++ GK++E
Sbjct: 1295 VQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIE 1334
>AL356257-1|CAI16722.1| 1325|Homo sapiens ATP-binding cassette,
sub-family C (CFTR/MRP), member 4 protein.
Length = 1325
Score = 133 bits (321), Expect = 4e-30
Identities = 78/239 (32%), Positives = 134/239 (56%), Gaps = 6/239 (2%)
Query: 392 GDILLEDVEFCY-PSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQA 450
G I+ ++V F Y P P VLK + +K E V +VG +G GKS+++ L RL +P+
Sbjct: 1039 GVIIFDNVNFMYSPGGP--LVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPE- 1095
Query: 451 GSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAY 510
G + LR + ++ QEPVLF GT+ N+ + E T EE+ +
Sbjct: 1096 GKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFN-EHTDEELWNALQEVQ 1154
Query: 511 AHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQ 570
+ I LP DT + E G++ S GQ+Q + +AR++LR+ +L++DEAT+ +DP ++
Sbjct: 1155 LKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDEL 1214
Query: 571 VQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAK-GFYHKLV 628
+Q + T +T++HRL+TI+++D+I+ +D G + E L++ K ++K+V
Sbjct: 1215 IQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMV 1273
Score = 123 bits (296), Expect = 5e-27
Identities = 189/830 (22%), Positives = 349/830 (42%), Gaps = 88/830 (10%)
Query: 396 LEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXX 455
++D + E L+G S V+PGE +A+VG G GKS++L + P G V
Sbjct: 412 VQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVS- 470
Query: 456 XXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFI 515
+ + V Q+P +F GT+ NI G + +E ++V + +
Sbjct: 471 ------------VHGRIAYVSQQPWVFSGTLRSNILFGK-KYEKERYEKVIKACALKKDL 517
Query: 516 SLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAA 574
LL +G TVIG+RG +LSGGQK R+ +AR++ ++ + LLD+ SA+D R + +
Sbjct: 518 QLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELC 577
Query: 575 LDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNEN 634
+ + + TI V+H+L + A +I+ I++ G M KG Y + + +G
Sbjct: 578 ICQILHEKITILVTHQLQYLKAASQIL------ILKDGK----MVQKGTYTEFLKSG--- 624
Query: 635 KEPADIEPLIEEADGDGDNIEPTVPSRLDVRRR--SSKKVLRHHSIKKDHPDW-LTPRGS 691
D L+++ + + + +P VP +R R S V S + D L + +
Sbjct: 625 ---IDFGSLLKKDNEESE--QPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGALESQDT 679
Query: 692 ISSMVSIGLQNFVFNXXXXXXXXXXXXXTVKTVSDWQLLKLNAPEWPLITVGSIAAFLQG 751
+ V++ +N + L+ LN T +A LQ
Sbjct: 680 ENVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLN-------TAAQVAYVLQD 732
Query: 752 ACFPVFA----LLFGFSSGIFILDNRDDIIYLADLYSVLFVVIAAVAGISMCLQSTTFTS 807
+A +L +G + + D+ + +YS L V + GI+ L +
Sbjct: 733 WWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGL-TVATVLFGIARSLL-VFYVL 790
Query: 808 AGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQG 867
T L ++ F S+LK + FFD+ N +G I R S D + L +Q
Sbjct: 791 VNSSQT--LHNKMFESILKAPVLFFDR--NPIGRILNRFSKDIGHLDDLLPLTFLDFIQT 846
Query: 868 ISSVVVGFLLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATE 927
+ VV +A++ + +A +PL + I+L + ++ +R + + + +
Sbjct: 847 LLQVVGVVSVAVAV---IPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSH 903
Query: 928 AVVSIK---TVQSLGVETVFLQKF---QDALKTACVAVAYKTRWRGLVYGLGVYIPFMAY 981
S++ T+++ E + F QD A +RW + A
Sbjct: 904 LSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFA--------VRLDAI 955
Query: 982 CSATVYGAVLVAYGEMEYKLVL---LVNEAIMYGAYMLGQ---SLVYAPSLNTAKACGAR 1035
C+ V ++VA+G + L V A+ Y ++G + + + R
Sbjct: 956 CAMFV---IIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVER 1012
Query: 1036 ILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCY-PTRPSQRVLKGIDLKMEAGKT 1094
++ + + + W G +V F Y P P VLK + +++ +
Sbjct: 1013 VIEYTDLEKEAPWEYQKRPPPAWPHEGVIIFDNVNFMYSPGGPL--VLKHLTALIKSQEK 1070
Query: 1095 IALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLD 1154
+ +VG +G GKS+++ R +P+ G I +D + + + + + LR+++ ++ QEPVL
Sbjct: 1071 VGIVGRTGAGKSSLISALFRLSEPE-GKIWID-KILTTEIGLHDLRKKMSIIPQEPVLFT 1128
Query: 1155 RSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP-KAVTEALEKAA 1203
++ +N+ D + T E+ A + + I LP K TE E +
Sbjct: 1129 GTMRKNL---DPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGS 1175
Score = 38.7 bits (86), Expect = 0.13
Identities = 31/120 (25%), Positives = 56/120 (46%), Gaps = 10/120 (8%)
Query: 1122 FIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAE---NIAYGDNNRKVTMHEIVAA 1178
F E + ++ +AL +L+ ++ P +D LAE N + G I+
Sbjct: 1138 FNEHTDEELWNALQEVQLKE---TIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRK 1194
Query: 1179 AKAANIHSFIVSLPKAVTEALEKAAKGR----TCITIAHRLSTVKDADLICVIDKGKIVE 1234
+ I ++ E ++K + + T +TIAHRL+T+ D+D I V+D G++ E
Sbjct: 1195 NQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKE 1254
>AL157818-1|CAC36037.2| 1325|Homo sapiens ATP-binding cassette,
sub-family C (CFTR/MRP), member 4 protein.
Length = 1325
Score = 133 bits (321), Expect = 4e-30
Identities = 78/239 (32%), Positives = 134/239 (56%), Gaps = 6/239 (2%)
Query: 392 GDILLEDVEFCY-PSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQA 450
G I+ ++V F Y P P VLK + +K E V +VG +G GKS+++ L RL +P+
Sbjct: 1039 GVIIFDNVNFMYSPGGP--LVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPE- 1095
Query: 451 GSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAY 510
G + LR + ++ QEPVLF GT+ N+ + E T EE+ +
Sbjct: 1096 GKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFN-EHTDEELWNALQEVQ 1154
Query: 511 AHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQ 570
+ I LP DT + E G++ S GQ+Q + +AR++LR+ +L++DEAT+ +DP ++
Sbjct: 1155 LKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDEL 1214
Query: 571 VQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAK-GFYHKLV 628
+Q + T +T++HRL+TI+++D+I+ +D G + E L++ K ++K+V
Sbjct: 1215 IQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMV 1273
Score = 123 bits (296), Expect = 5e-27
Identities = 189/830 (22%), Positives = 349/830 (42%), Gaps = 88/830 (10%)
Query: 396 LEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXX 455
++D + E L+G S V+PGE +A+VG G GKS++L + P G V
Sbjct: 412 VQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVS- 470
Query: 456 XXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFI 515
+ + V Q+P +F GT+ NI G + +E ++V + +
Sbjct: 471 ------------VHGRIAYVSQQPWVFSGTLRSNILFGK-KYEKERYEKVIKACALKKDL 517
Query: 516 SLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAA 574
LL +G TVIG+RG +LSGGQK R+ +AR++ ++ + LLD+ SA+D R + +
Sbjct: 518 QLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELC 577
Query: 575 LDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNEN 634
+ + + TI V+H+L + A +I+ I++ G M KG Y + + +G
Sbjct: 578 ICQILHEKITILVTHQLQYLKAASQIL------ILKDGK----MVQKGTYTEFLKSG--- 624
Query: 635 KEPADIEPLIEEADGDGDNIEPTVPSRLDVRRR--SSKKVLRHHSIKKDHPDW-LTPRGS 691
D L+++ + + + +P VP +R R S V S + D L + +
Sbjct: 625 ---IDFGSLLKKDNEESE--QPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGALESQDT 679
Query: 692 ISSMVSIGLQNFVFNXXXXXXXXXXXXXTVKTVSDWQLLKLNAPEWPLITVGSIAAFLQG 751
+ V++ +N + L+ LN T +A LQ
Sbjct: 680 ENVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLN-------TAAQVAYVLQD 732
Query: 752 ACFPVFA----LLFGFSSGIFILDNRDDIIYLADLYSVLFVVIAAVAGISMCLQSTTFTS 807
+A +L +G + + D+ + +YS L V + GI+ L +
Sbjct: 733 WWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGL-TVATVLFGIARSLL-VFYVL 790
Query: 808 AGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQG 867
T L ++ F S+LK + FFD+ N +G I R S D + L +Q
Sbjct: 791 VNSSQT--LHNKMFESILKAPVLFFDR--NPIGRILNRFSKDIGHLDDLLPLTFLDFIQT 846
Query: 868 ISSVVVGFLLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATE 927
+ VV +A++ + +A +PL + I+L + ++ +R + + + +
Sbjct: 847 LLQVVGVVSVAVAV---IPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSH 903
Query: 928 AVVSIK---TVQSLGVETVFLQKF---QDALKTACVAVAYKTRWRGLVYGLGVYIPFMAY 981
S++ T+++ E + F QD A +RW + A
Sbjct: 904 LSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFA--------VRLDAI 955
Query: 982 CSATVYGAVLVAYGEMEYKLVL---LVNEAIMYGAYMLGQ---SLVYAPSLNTAKACGAR 1035
C+ V ++VA+G + L V A+ Y ++G + + + R
Sbjct: 956 CAMFV---IIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVER 1012
Query: 1036 ILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCY-PTRPSQRVLKGIDLKMEAGKT 1094
++ + + + W G +V F Y P P VLK + +++ +
Sbjct: 1013 VIEYTDLEKEAPWEYQKRPPPAWPHEGVIIFDNVNFMYSPGGPL--VLKHLTALIKSQEK 1070
Query: 1095 IALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLD 1154
+ +VG +G GKS+++ R +P+ G I +D + + + + + LR+++ ++ QEPVL
Sbjct: 1071 VGIVGRTGAGKSSLISALFRLSEPE-GKIWID-KILTTEIGLHDLRKKMSIIPQEPVLFT 1128
Query: 1155 RSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP-KAVTEALEKAA 1203
++ +N+ D + T E+ A + + I LP K TE E +
Sbjct: 1129 GTMRKNL---DPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGS 1175
Score = 38.7 bits (86), Expect = 0.13
Identities = 31/120 (25%), Positives = 56/120 (46%), Gaps = 10/120 (8%)
Query: 1122 FIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAE---NIAYGDNNRKVTMHEIVAA 1178
F E + ++ +AL +L+ ++ P +D LAE N + G I+
Sbjct: 1138 FNEHTDEELWNALQEVQLKE---TIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRK 1194
Query: 1179 AKAANIHSFIVSLPKAVTEALEKAAKGR----TCITIAHRLSTVKDADLICVIDKGKIVE 1234
+ I ++ E ++K + + T +TIAHRL+T+ D+D I V+D G++ E
Sbjct: 1195 NQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKE 1254
>AL139381-1|CAI16589.1| 1325|Homo sapiens ATP-binding cassette,
sub-family C (CFTR/MRP), member 4 protein.
Length = 1325
Score = 133 bits (321), Expect = 4e-30
Identities = 78/239 (32%), Positives = 134/239 (56%), Gaps = 6/239 (2%)
Query: 392 GDILLEDVEFCY-PSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQA 450
G I+ ++V F Y P P VLK + +K E V +VG +G GKS+++ L RL +P+
Sbjct: 1039 GVIIFDNVNFMYSPGGP--LVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPE- 1095
Query: 451 GSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAY 510
G + LR + ++ QEPVLF GT+ N+ + E T EE+ +
Sbjct: 1096 GKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFN-EHTDEELWNALQEVQ 1154
Query: 511 AHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQ 570
+ I LP DT + E G++ S GQ+Q + +AR++LR+ +L++DEAT+ +DP ++
Sbjct: 1155 LKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDEL 1214
Query: 571 VQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAK-GFYHKLV 628
+Q + T +T++HRL+TI+++D+I+ +D G + E L++ K ++K+V
Sbjct: 1215 IQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMV 1273
Score = 123 bits (296), Expect = 5e-27
Identities = 189/830 (22%), Positives = 349/830 (42%), Gaps = 88/830 (10%)
Query: 396 LEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXX 455
++D + E L+G S V+PGE +A+VG G GKS++L + P G V
Sbjct: 412 VQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVS- 470
Query: 456 XXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFI 515
+ + V Q+P +F GT+ NI G + +E ++V + +
Sbjct: 471 ------------VHGRIAYVSQQPWVFSGTLRSNILFGK-KYEKERYEKVIKACALKKDL 517
Query: 516 SLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAA 574
LL +G TVIG+RG +LSGGQK R+ +AR++ ++ + LLD+ SA+D R + +
Sbjct: 518 QLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELC 577
Query: 575 LDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNEN 634
+ + + TI V+H+L + A +I+ I++ G M KG Y + + +G
Sbjct: 578 ICQILHEKITILVTHQLQYLKAASQIL------ILKDGK----MVQKGTYTEFLKSG--- 624
Query: 635 KEPADIEPLIEEADGDGDNIEPTVPSRLDVRRR--SSKKVLRHHSIKKDHPDW-LTPRGS 691
D L+++ + + + +P VP +R R S V S + D L + +
Sbjct: 625 ---IDFGSLLKKDNEESE--QPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGALESQDT 679
Query: 692 ISSMVSIGLQNFVFNXXXXXXXXXXXXXTVKTVSDWQLLKLNAPEWPLITVGSIAAFLQG 751
+ V++ +N + L+ LN T +A LQ
Sbjct: 680 ENVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLN-------TAAQVAYVLQD 732
Query: 752 ACFPVFA----LLFGFSSGIFILDNRDDIIYLADLYSVLFVVIAAVAGISMCLQSTTFTS 807
+A +L +G + + D+ + +YS L V + GI+ L +
Sbjct: 733 WWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGL-TVATVLFGIARSLL-VFYVL 790
Query: 808 AGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQG 867
T L ++ F S+LK + FFD+ N +G I R S D + L +Q
Sbjct: 791 VNSSQT--LHNKMFESILKAPVLFFDR--NPIGRILNRFSKDIGHLDDLLPLTFLDFIQT 846
Query: 868 ISSVVVGFLLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATE 927
+ VV +A++ + +A +PL + I+L + ++ +R + + + +
Sbjct: 847 LLQVVGVVSVAVAV---IPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSH 903
Query: 928 AVVSIK---TVQSLGVETVFLQKF---QDALKTACVAVAYKTRWRGLVYGLGVYIPFMAY 981
S++ T+++ E + F QD A +RW + A
Sbjct: 904 LSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFA--------VRLDAI 955
Query: 982 CSATVYGAVLVAYGEMEYKLVL---LVNEAIMYGAYMLGQ---SLVYAPSLNTAKACGAR 1035
C+ V ++VA+G + L V A+ Y ++G + + + R
Sbjct: 956 CAMFV---IIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVER 1012
Query: 1036 ILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCY-PTRPSQRVLKGIDLKMEAGKT 1094
++ + + + W G +V F Y P P VLK + +++ +
Sbjct: 1013 VIEYTDLEKEAPWEYQKRPPPAWPHEGVIIFDNVNFMYSPGGPL--VLKHLTALIKSQEK 1070
Query: 1095 IALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLD 1154
+ +VG +G GKS+++ R +P+ G I +D + + + + + LR+++ ++ QEPVL
Sbjct: 1071 VGIVGRTGAGKSSLISALFRLSEPE-GKIWID-KILTTEIGLHDLRKKMSIIPQEPVLFT 1128
Query: 1155 RSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP-KAVTEALEKAA 1203
++ +N+ D + T E+ A + + I LP K TE E +
Sbjct: 1129 GTMRKNL---DPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGS 1175
Score = 38.7 bits (86), Expect = 0.13
Identities = 31/120 (25%), Positives = 56/120 (46%), Gaps = 10/120 (8%)
Query: 1122 FIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAE---NIAYGDNNRKVTMHEIVAA 1178
F E + ++ +AL +L+ ++ P +D LAE N + G I+
Sbjct: 1138 FNEHTDEELWNALQEVQLKE---TIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRK 1194
Query: 1179 AKAANIHSFIVSLPKAVTEALEKAAKGR----TCITIAHRLSTVKDADLICVIDKGKIVE 1234
+ I ++ E ++K + + T +TIAHRL+T+ D+D I V+D G++ E
Sbjct: 1195 NQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKE 1254
>AF541977-1|AAN17334.1| 1278|Homo sapiens ATP-binding cassette protein
C4 splice variant A protein.
Length = 1278
Score = 133 bits (321), Expect = 4e-30
Identities = 78/239 (32%), Positives = 134/239 (56%), Gaps = 6/239 (2%)
Query: 392 GDILLEDVEFCY-PSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQA 450
G I+ ++V F Y P P VLK + +K E V +VG +G GKS+++ L RL +P+
Sbjct: 992 GVIIFDNVNFMYSPGGP--LVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPE- 1048
Query: 451 GSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAY 510
G + LR + ++ QEPVLF GT+ N+ + E T EE+ +
Sbjct: 1049 GKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFN-EHTDEELWNALQEVQ 1107
Query: 511 AHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQ 570
+ I LP DT + E G++ S GQ+Q + +AR++LR+ +L++DEAT+ +DP ++
Sbjct: 1108 LKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDEL 1167
Query: 571 VQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAK-GFYHKLV 628
+Q + T +T++HRL+TI+++D+I+ +D G + E L++ K ++K+V
Sbjct: 1168 IQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMV 1226
Score = 113 bits (273), Expect = 3e-24
Identities = 72/242 (29%), Positives = 125/242 (51%), Gaps = 15/242 (6%)
Query: 396 LEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXX 455
++D + E L+G S V+PGE +A+VG G GKS++L + P G V
Sbjct: 412 VQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVS- 470
Query: 456 XXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFI 515
+ + V Q+P +F GT+ NI G + +E ++V + +
Sbjct: 471 ------------VHGRIAYVSQQPWVFSGTLRSNILFGK-KYEKERYEKVIKACALKKDL 517
Query: 516 SLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAA 574
LL +G TVIG+RG +LSGGQK R+ +AR++ ++ + LLD+ SA+D R + +
Sbjct: 518 QLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELC 577
Query: 575 LDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNEN 634
+ + + TI V+H+L + A +I+ + G +V++GT+ + +K+ + L+ NE
Sbjct: 578 ICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDNEE 637
Query: 635 KE 636
E
Sbjct: 638 SE 639
Score = 56.0 bits (129), Expect = 8e-07
Identities = 86/402 (21%), Positives = 169/402 (42%), Gaps = 37/402 (9%)
Query: 816 LRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGF 875
L ++ F S+LK + FFD+ N +G I R S D + L +Q + VV
Sbjct: 750 LHNKMFESILKAPVLFFDR--NPIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGVV 807
Query: 876 LLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIK-- 933
+A++ + +A +PL + I+L + ++ +R + + + + S++
Sbjct: 808 SVAVAV---IPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGL 864
Query: 934 -TVQSLGVETVFLQKF---QDALKTACVAVAYKTRWRGLVYGLGVYIPFMAYCSATVYGA 989
T+++ E + F QD A +RW + A C+ V
Sbjct: 865 WTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFA--------VRLDAICAMFV--- 913
Query: 990 VLVAYGEMEYKLVL---LVNEAIMYGAYMLGQ---SLVYAPSLNTAKACGARILSIIQRQ 1043
++VA+G + L V A+ Y ++G + + + R++ +
Sbjct: 914 IIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLE 973
Query: 1044 PKIHNAVGVKDKKDWVASGNFSMRDVEFCY-PTRPSQRVLKGIDLKMEAGKTIALVGSSG 1102
+ + W G +V F Y P P VLK + +++ + + +VG +G
Sbjct: 974 KEAPWEYQKRPPPAWPHEGVIIFDNVNFMYSPGGPL--VLKHLTALIKSQEKVGIVGRTG 1031
Query: 1103 CGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIA 1162
GKS+++ R +P+ G I +D + + + + + LR+++ ++ QEPVL ++ +N+
Sbjct: 1032 AGKSSLISALFRLSEPE-GKIWID-KILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNL- 1088
Query: 1163 YGDNNRKVTMHEIVAAAKAANIHSFIVSLP-KAVTEALEKAA 1203
D + T E+ A + + I LP K TE E +
Sbjct: 1089 --DPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGS 1128
Score = 38.7 bits (86), Expect = 0.13
Identities = 31/120 (25%), Positives = 56/120 (46%), Gaps = 10/120 (8%)
Query: 1122 FIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAE---NIAYGDNNRKVTMHEIVAA 1178
F E + ++ +AL +L+ ++ P +D LAE N + G I+
Sbjct: 1091 FNEHTDEELWNALQEVQLKE---TIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRK 1147
Query: 1179 AKAANIHSFIVSLPKAVTEALEKAAKGR----TCITIAHRLSTVKDADLICVIDKGKIVE 1234
+ I ++ E ++K + + T +TIAHRL+T+ D+D I V+D G++ E
Sbjct: 1148 NQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKE 1207
Score = 34.7 bits (76), Expect = 2.1
Identities = 23/97 (23%), Positives = 41/97 (42%), Gaps = 14/97 (14%)
Query: 1082 LKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRR 1141
L+G+ + G+ +A+VG G GKS++L P G + + R
Sbjct: 428 LQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGR------------- 474
Query: 1142 QLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAA 1178
+ V Q+P + +L NI +G K +++ A
Sbjct: 475 -IAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKA 510
>AF071203-1|AAC27077.1| 893|Homo sapiens ABC transporter MOAT-B
isoform protein.
Length = 893
Score = 133 bits (321), Expect = 4e-30
Identities = 78/239 (32%), Positives = 133/239 (55%), Gaps = 6/239 (2%)
Query: 392 GDILLEDVEFCY-PSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQA 450
G I+ ++V F Y P P VLK + +K E V +VG +G GKS+++ L RL +P+
Sbjct: 629 GVIIFDNVNFMYSPGGP--LVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPE- 685
Query: 451 GSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAY 510
G + LR + ++ QEPVLF GT+ N+ E T EE+ +
Sbjct: 686 GKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLD-PFKEHTDEELWNALQEVQ 744
Query: 511 AHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQ 570
+ I LP DT + E G++ S GQ+Q + +AR++LR+ +L++DEAT+ +DP ++
Sbjct: 745 LKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDEL 804
Query: 571 VQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAK-GFYHKLV 628
+Q + T +T++HRL+TI+++D+I+ +D G + E L++ K ++K+V
Sbjct: 805 IQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMV 863
Score = 124 bits (298), Expect = 3e-27
Identities = 189/830 (22%), Positives = 350/830 (42%), Gaps = 88/830 (10%)
Query: 396 LEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXX 455
++D + E L+G S V+PGE +A+VG G GKS++L + P G V
Sbjct: 2 VQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVS- 60
Query: 456 XXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFI 515
+ + V Q+P +F GT+ NI G + +E ++V + +
Sbjct: 61 ------------VHGRIAYVSQQPWVFSGTLRSNILFGK-KYEKERYEKVIKACALKKDL 107
Query: 516 SLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAA 574
LL +G TVIG+RG +LSGGQK R+ +AR++ ++ + LLD+ SA+D R + +
Sbjct: 108 QLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELC 167
Query: 575 LDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNEN 634
+ + + TI V+H+L + A +I+ I++ G M KG Y + + +G
Sbjct: 168 ICQILHEKITILVTHQLQYLKAASQIL------ILKDGK----MVQKGTYTEFLKSG--- 214
Query: 635 KEPADIEPLIEEADGDGDNIEPTVPSRLDVRRR--SSKKVLRHHSIKKDHPDW-LTPRGS 691
D L+++ + + + +P VP +R R S V S + D L + +
Sbjct: 215 ---IDFGSLLKKDNEESE--QPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGALESQDT 269
Query: 692 ISSMVSIGLQNFVFNXXXXXXXXXXXXXTVKTVSDWQLLKLNAPEWPLITVGSIAAFLQG 751
+ V++ +N + L+ LN T +A LQ
Sbjct: 270 ENVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLN-------TAAQVAYVLQD 322
Query: 752 ACFPVFA----LLFGFSSGIFILDNRDDIIYLADLYSVLFVVIAAVAGISMCLQSTTFTS 807
+A +L +G + + D+ + +YS L V + GI+ L +
Sbjct: 323 WWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGL-TVATVLFGIARSLL-VFYVL 380
Query: 808 AGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQG 867
T L ++ F S+LK + FFD+ N +G I R S D + L +Q
Sbjct: 381 VNSSQT--LHNKMFESILKAPVLFFDR--NPIGRILNRFSKDIGHLDDLLPLTFLDFIQT 436
Query: 868 ISSVVVGFLLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATE 927
+ VV +A++ + +A +PL + I+L + ++ +R + + + +
Sbjct: 437 LLQVVGVVSVAVAV---IPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSH 493
Query: 928 AVVSIK---TVQSLGVETVFLQKF---QDALKTACVAVAYKTRWRGLVYGLGVYIPFMAY 981
S++ T+++ E + F QD A +RW + A
Sbjct: 494 LSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFA--------VRLDAI 545
Query: 982 CSATVYGAVLVAYGEMEYKLVL---LVNEAIMYGAYMLGQ---SLVYAPSLNTAKACGAR 1035
C+ V ++VA+G + L V A+ Y ++G + + + R
Sbjct: 546 CAMFV---IIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVER 602
Query: 1036 ILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCY-PTRPSQRVLKGIDLKMEAGKT 1094
++ + + + W G +V F Y P P VLK + +++ +
Sbjct: 603 VIEYTDLEKEAPWEYQKRPPPAWPHEGVIIFDNVNFMYSPGGPL--VLKHLTALIKSQEK 660
Query: 1095 IALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLD 1154
+ +VG +G GKS+++ R +P+ G I +D + + + + + LR+++ ++ QEPVL
Sbjct: 661 VGIVGRTGAGKSSLISALFRLSEPE-GKIWID-KILTTEIGLHDLRKKMSIIPQEPVLFT 718
Query: 1155 RSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP-KAVTEALEKAA 1203
++ +N+ D ++ T E+ A + + I LP K TE E +
Sbjct: 719 GTMRKNL---DPFKEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGS 765
Score = 38.7 bits (86), Expect = 0.13
Identities = 31/120 (25%), Positives = 56/120 (46%), Gaps = 10/120 (8%)
Query: 1122 FIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAE---NIAYGDNNRKVTMHEIVAA 1178
F E + ++ +AL +L+ ++ P +D LAE N + G I+
Sbjct: 728 FKEHTDEELWNALQEVQLKE---TIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRK 784
Query: 1179 AKAANIHSFIVSLPKAVTEALEKAAKGR----TCITIAHRLSTVKDADLICVIDKGKIVE 1234
+ I ++ E ++K + + T +TIAHRL+T+ D+D I V+D G++ E
Sbjct: 785 NQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKE 844
>AF071202-1|AAC27076.1| 1325|Homo sapiens ABC transporter MOAT-B
protein.
Length = 1325
Score = 133 bits (321), Expect = 4e-30
Identities = 78/239 (32%), Positives = 133/239 (55%), Gaps = 6/239 (2%)
Query: 392 GDILLEDVEFCY-PSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQA 450
G I+ ++V F Y P P VLK + +K E V +VG +G GKS+++ L RL +P+
Sbjct: 1039 GVIIFDNVNFMYSPGGP--LVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPE- 1095
Query: 451 GSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAY 510
G + LR + ++ QEPVLF GT+ N+ E T EE+ +
Sbjct: 1096 GKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLD-PFKEHTDEELWNALQEVQ 1154
Query: 511 AHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQ 570
+ I LP DT + E G++ S GQ+Q + +AR++LR+ +L++DEAT+ +DP ++
Sbjct: 1155 LKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDEL 1214
Query: 571 VQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAK-GFYHKLV 628
+Q + T +T++HRL+TI+++D+I+ +D G + E L++ K ++K+V
Sbjct: 1215 IQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMV 1273
Score = 124 bits (298), Expect = 3e-27
Identities = 189/830 (22%), Positives = 350/830 (42%), Gaps = 88/830 (10%)
Query: 396 LEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXX 455
++D + E L+G S V+PGE +A+VG G GKS++L + P G V
Sbjct: 412 VQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVS- 470
Query: 456 XXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFI 515
+ + V Q+P +F GT+ NI G + +E ++V + +
Sbjct: 471 ------------VHGRIAYVSQQPWVFSGTLRSNILFGK-KYEKERYEKVIKACALKKDL 517
Query: 516 SLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAA 574
LL +G TVIG+RG +LSGGQK R+ +AR++ ++ + LLD+ SA+D R + +
Sbjct: 518 QLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELC 577
Query: 575 LDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNEN 634
+ + + TI V+H+L + A +I+ I++ G M KG Y + + +G
Sbjct: 578 ICQILHEKITILVTHQLQYLKAASQIL------ILKDGK----MVQKGTYTEFLKSG--- 624
Query: 635 KEPADIEPLIEEADGDGDNIEPTVPSRLDVRRR--SSKKVLRHHSIKKDHPDW-LTPRGS 691
D L+++ + + + +P VP +R R S V S + D L + +
Sbjct: 625 ---IDFGSLLKKDNEESE--QPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGALESQDT 679
Query: 692 ISSMVSIGLQNFVFNXXXXXXXXXXXXXTVKTVSDWQLLKLNAPEWPLITVGSIAAFLQG 751
+ V++ +N + L+ LN T +A LQ
Sbjct: 680 ENVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLN-------TAAQVAYVLQD 732
Query: 752 ACFPVFA----LLFGFSSGIFILDNRDDIIYLADLYSVLFVVIAAVAGISMCLQSTTFTS 807
+A +L +G + + D+ + +YS L V + GI+ L +
Sbjct: 733 WWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGL-TVATVLFGIARSLL-VFYVL 790
Query: 808 AGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQG 867
T L ++ F S+LK + FFD+ N +G I R S D + L +Q
Sbjct: 791 VNSSQT--LHNKMFESILKAPVLFFDR--NPIGRILNRFSKDIGHLDDLLPLTFLDFIQT 846
Query: 868 ISSVVVGFLLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATE 927
+ VV +A++ + +A +PL + I+L + ++ +R + + + +
Sbjct: 847 LLQVVGVVSVAVAV---IPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSH 903
Query: 928 AVVSIK---TVQSLGVETVFLQKF---QDALKTACVAVAYKTRWRGLVYGLGVYIPFMAY 981
S++ T+++ E + F QD A +RW + A
Sbjct: 904 LSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFA--------VRLDAI 955
Query: 982 CSATVYGAVLVAYGEMEYKLVL---LVNEAIMYGAYMLGQ---SLVYAPSLNTAKACGAR 1035
C+ V ++VA+G + L V A+ Y ++G + + + R
Sbjct: 956 CAMFV---IIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVER 1012
Query: 1036 ILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCY-PTRPSQRVLKGIDLKMEAGKT 1094
++ + + + W G +V F Y P P VLK + +++ +
Sbjct: 1013 VIEYTDLEKEAPWEYQKRPPPAWPHEGVIIFDNVNFMYSPGGPL--VLKHLTALIKSQEK 1070
Query: 1095 IALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLD 1154
+ +VG +G GKS+++ R +P+ G I +D + + + + + LR+++ ++ QEPVL
Sbjct: 1071 VGIVGRTGAGKSSLISALFRLSEPE-GKIWID-KILTTEIGLHDLRKKMSIIPQEPVLFT 1128
Query: 1155 RSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP-KAVTEALEKAA 1203
++ +N+ D ++ T E+ A + + I LP K TE E +
Sbjct: 1129 GTMRKNL---DPFKEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGS 1175
Score = 38.7 bits (86), Expect = 0.13
Identities = 31/120 (25%), Positives = 56/120 (46%), Gaps = 10/120 (8%)
Query: 1122 FIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAE---NIAYGDNNRKVTMHEIVAA 1178
F E + ++ +AL +L+ ++ P +D LAE N + G I+
Sbjct: 1138 FKEHTDEELWNALQEVQLKE---TIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRK 1194
Query: 1179 AKAANIHSFIVSLPKAVTEALEKAAKGR----TCITIAHRLSTVKDADLICVIDKGKIVE 1234
+ I ++ E ++K + + T +TIAHRL+T+ D+D I V+D G++ E
Sbjct: 1195 NQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKE 1254
>AB019002-1|BAA76608.1| 1437|Homo sapiens MRP5 protein.
Length = 1437
Score = 132 bits (319), Expect = 8e-30
Identities = 131/528 (24%), Positives = 229/528 (43%), Gaps = 21/528 (3%)
Query: 114 ISIGVSLVFCVLSFSLISWSALRQITRIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENL 173
+S+ V L+ + + LR +R+ R +LR M ++DT + ++ S+++
Sbjct: 920 LSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFSKDM 979
Query: 174 MSIKEGMGEKLAV-VSN--LVGTSVICLCTAFPLGWQLTLACAAVMPFSVITSIALSNYQ 230
+ + + + + N LV V + FP W L V+ FSV+ ++ +
Sbjct: 980 DEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFP--WFLVAVGPLVILFSVLHIVSRVLIR 1037
Query: 231 TKSSIREMESYSLAGKQAEEILKSVRTIVAFGGENKEVERYRRLLEPAEEFGRKRGLFTG 290
+ + I + + TI A+ + + RY+ LL+ + LFT
Sbjct: 1038 ELKRLDNITQSPFLSHITSSI-QGLATIHAYNKGQEFLHRYQELLDDNQA---PFFLFTC 1093
Query: 291 LGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVYSILFSVYMATQSITFC 350
W L L+ I + T + + P A +I ++V + T F
Sbjct: 1094 ---AMRW-LAVRLDLISIALITTTGLMIVLMHGQIP--PAYAGLAISYAVQL-TGLFQFT 1146
Query: 351 VPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPRR---VVGDILLEDVEFCYPSRP 407
V I H I+ + K P G++ E+ E Y
Sbjct: 1147 VRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENL 1206
Query: 408 EVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSW 467
+ VLK S +KP E + +VG +G GKS++ L RL + G + +
Sbjct: 1207 PL-VLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLAD 1265
Query: 468 LRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIG 527
LRS L ++ QEPVLF GT+ N+ + + T ++I E + + I+ LP ++ +
Sbjct: 1266 LRSKLSIIPQEPVLFSGTVRSNLDPFN-QYTEDQIWDALERTHMKECIAQLPLKLESEVM 1324
Query: 528 ERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITV 587
E G + S G++Q + IAR+LLR +L+LDEAT+A+D ++ +Q + A T + +
Sbjct: 1325 ENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLNI 1384
Query: 588 SHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENK 635
+HRL T++ +DRI+ + QG +VE T L+ + ENK
Sbjct: 1385 AHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAMFAAAENK 1432
Score = 114 bits (274), Expect = 2e-24
Identities = 67/216 (31%), Positives = 112/216 (51%), Gaps = 15/216 (6%)
Query: 410 KVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLR 469
+ L + ++ G+ V + GS G GK++++ + GS+ +
Sbjct: 576 RTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIA-------------IS 622
Query: 470 SSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGER 529
+ V Q+ + T+ DNI G E E V +++LP+ T IGER
Sbjct: 623 GTFAYVAQQAWILNATLRDNILFGK-EYDEERYNSVLNSCCLRPDLAILPSSDLTEIGER 681
Query: 530 GASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVS 588
GA+LSGGQ+QRI++AR+L + ++ +LD+ SALD H + +A+ + +T + V+
Sbjct: 682 GANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVT 741
Query: 589 HRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFY 624
H+L +V+ D +I M +G I E+GTHE+LM G Y
Sbjct: 742 HQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDY 777
Score = 84.6 bits (200), Expect = 2e-15
Identities = 98/430 (22%), Positives = 178/430 (41%), Gaps = 30/430 (6%)
Query: 783 YSVLFVVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAI 842
Y+ ++ + AV I ++ F L+ ++RL + F +L+ + FFD T G I
Sbjct: 914 YASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFD--TTPTGRI 971
Query: 843 CARLSGDTAEVQGATGLRIGLILQGISSVV--VGFLLAISYNWKLTLVATVFLPLMVGSI 900
R S D EV + + +Q + V VG + + + W L V + + V I
Sbjct: 972 LNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGV-FPWFLVAVGPLVILFSVLHI 1030
Query: 901 WLEGIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDAL---KTACV 957
+I + ++D + I T ++ + T+ + FL ++Q+ L +
Sbjct: 1031 VSRVLIRELKRLDNITQSPFLSHI-TSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFF 1089
Query: 958 AVAYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVA-YGEMEYKLVLLVNEAIMYGAYML 1016
RW L V + ++ T G ++V +G++ L AI Y +
Sbjct: 1090 LFTCAMRW------LAVRLDLISIALITTTGLMIVLMHGQIPPAYAGL---AISYAVQLT 1140
Query: 1017 G--QSLVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKK---DWVASGNFSMRDVEF 1071
G Q V S A+ ++ + + +K+K DW G + + E
Sbjct: 1141 GLFQFTVRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEM 1200
Query: 1072 CYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIR 1131
Y VLK + ++ + I +VG +G GKS++ R + G I++D I
Sbjct: 1201 RYREN-LPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRI- 1258
Query: 1132 SALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSL 1191
S + + LR +L ++ QEPVL ++ N+ D + T +I A + ++ I L
Sbjct: 1259 SDIGLADLRSKLSIIPQEPVLFSGTVRSNL---DPFNQYTEDQIWDALERTHMKECIAQL 1315
Query: 1192 P-KAVTEALE 1200
P K +E +E
Sbjct: 1316 PLKLESEVME 1325
Score = 45.6 bits (103), Expect = 0.001
Identities = 19/51 (37%), Positives = 31/51 (60%)
Query: 1198 ALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHY 1248
A+ K K +T + + H+L + D D + + +G I ERGTH EL+++ G Y
Sbjct: 727 AIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDY 777
Score = 39.5 bits (88), Expect = 0.075
Identities = 34/109 (31%), Positives = 55/109 (50%), Gaps = 15/109 (13%)
Query: 1146 VQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKA----------- 1194
+ Q P+ L+ + EN GDN V +++ A+A H I+ L +A
Sbjct: 1312 IAQLPLKLESEVMEN---GDNF-SVGERQLLCIARALLRHCKILILDEATAAMDTETDLL 1367
Query: 1195 VTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVS 1243
+ E + +A T + IAHRL TV +D I V+ +G++VE T + L+S
Sbjct: 1368 IQETIREAFADCTMLNIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLS 1416
Score = 33.9 bits (74), Expect = 3.7
Identities = 13/31 (41%), Positives = 22/31 (70%)
Query: 1079 QRVLKGIDLKMEAGKTIALVGSSGCGKSTIL 1109
QR L IDL+++ GK + + GS G GK++++
Sbjct: 575 QRTLHSIDLEIQEGKLVGICGSVGSGKTSLI 605
>AB005659-1|BAA22887.1| 946|Homo sapiens SMRP protein.
Length = 946
Score = 132 bits (319), Expect = 8e-30
Identities = 131/528 (24%), Positives = 229/528 (43%), Gaps = 21/528 (3%)
Query: 114 ISIGVSLVFCVLSFSLISWSALRQITRIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENL 173
+S+ V L+ + + LR +R+ R +LR M ++DT + ++ S+++
Sbjct: 429 LSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFSKDM 488
Query: 174 MSIKEGMGEKLAV-VSN--LVGTSVICLCTAFPLGWQLTLACAAVMPFSVITSIALSNYQ 230
+ + + + + N LV V + FP W L V+ FSV+ ++ +
Sbjct: 489 DEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFP--WFLVAVGPLVILFSVLHIVSRVLIR 546
Query: 231 TKSSIREMESYSLAGKQAEEILKSVRTIVAFGGENKEVERYRRLLEPAEEFGRKRGLFTG 290
+ + I + + TI A+ + + RY+ LL+ + LFT
Sbjct: 547 ELKRLDNITQSPFLSHITSSI-QGLATIHAYNKGQEFLHRYQELLDDNQA---PFFLFTC 602
Query: 291 LGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVYSILFSVYMATQSITFC 350
W L L+ I + T + + P A +I ++V + T F
Sbjct: 603 ---AMRW-LAVRLDLISIALITTTGLMIVLMHGQIP--PAYAGLAISYAVQL-TGLFQFT 655
Query: 351 VPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPRR---VVGDILLEDVEFCYPSRP 407
V I H I+ + K P G++ E+ E Y
Sbjct: 656 VRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENL 715
Query: 408 EVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSW 467
+ VLK S +KP E + +VG +G GKS++ L RL + G + +
Sbjct: 716 PL-VLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLAD 774
Query: 468 LRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIG 527
LRS L ++ QEPVLF GT+ N+ + + T ++I E + + I+ LP ++ +
Sbjct: 775 LRSKLSIIPQEPVLFSGTVRSNLDPFN-QYTEDQIWDALERTHMKECIAQLPLKLESEVM 833
Query: 528 ERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITV 587
E G + S G++Q + IAR+LLR +L+LDEAT+A+D ++ +Q + A T + +
Sbjct: 834 ENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLNI 893
Query: 588 SHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENK 635
+HRL T++ +DRI+ + QG +VE T L+ + ENK
Sbjct: 894 AHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAMFAAAENK 941
Score = 114 bits (274), Expect = 2e-24
Identities = 67/216 (31%), Positives = 112/216 (51%), Gaps = 15/216 (6%)
Query: 410 KVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLR 469
+ L + ++ G+ V + GS G GK++++ + GS+ +
Sbjct: 85 RTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIA-------------IS 131
Query: 470 SSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGER 529
+ V Q+ + T+ DNI G E E V +++LP+ T IGER
Sbjct: 132 GTFAYVAQQAWILNATLRDNILFGK-EYDEERYNSVLNSCCLRPDLAILPSSDLTEIGER 190
Query: 530 GASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVS 588
GA+LSGGQ+QRI++AR+L + ++ +LD+ SALD H + +A+ + +T + V+
Sbjct: 191 GANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVT 250
Query: 589 HRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFY 624
H+L +V+ D +I M +G I E+GTHE+LM G Y
Sbjct: 251 HQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDY 286
Score = 84.6 bits (200), Expect = 2e-15
Identities = 98/430 (22%), Positives = 178/430 (41%), Gaps = 30/430 (6%)
Query: 783 YSVLFVVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAI 842
Y+ ++ + AV I ++ F L+ ++RL + F +L+ + FFD T G I
Sbjct: 423 YASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFD--TTPTGRI 480
Query: 843 CARLSGDTAEVQGATGLRIGLILQGISSVV--VGFLLAISYNWKLTLVATVFLPLMVGSI 900
R S D EV + + +Q + V VG + + + W L V + + V I
Sbjct: 481 LNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGV-FPWFLVAVGPLVILFSVLHI 539
Query: 901 WLEGIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDAL---KTACV 957
+I + ++D + I T ++ + T+ + FL ++Q+ L +
Sbjct: 540 VSRVLIRELKRLDNITQSPFLSHI-TSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFF 598
Query: 958 AVAYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVA-YGEMEYKLVLLVNEAIMYGAYML 1016
RW L V + ++ T G ++V +G++ L AI Y +
Sbjct: 599 LFTCAMRW------LAVRLDLISIALITTTGLMIVLMHGQIPPAYAGL---AISYAVQLT 649
Query: 1017 G--QSLVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKK---DWVASGNFSMRDVEF 1071
G Q V S A+ ++ + + +K+K DW G + + E
Sbjct: 650 GLFQFTVRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEM 709
Query: 1072 CYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIR 1131
Y VLK + ++ + I +VG +G GKS++ R + G I++D I
Sbjct: 710 RYREN-LPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRI- 767
Query: 1132 SALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSL 1191
S + + LR +L ++ QEPVL ++ N+ D + T +I A + ++ I L
Sbjct: 768 SDIGLADLRSKLSIIPQEPVLFSGTVRSNL---DPFNQYTEDQIWDALERTHMKECIAQL 824
Query: 1192 P-KAVTEALE 1200
P K +E +E
Sbjct: 825 PLKLESEVME 834
Score = 45.6 bits (103), Expect = 0.001
Identities = 19/51 (37%), Positives = 31/51 (60%)
Query: 1198 ALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHY 1248
A+ K K +T + + H+L + D D + + +G I ERGTH EL+++ G Y
Sbjct: 236 AIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDY 286
Score = 39.5 bits (88), Expect = 0.075
Identities = 34/109 (31%), Positives = 55/109 (50%), Gaps = 15/109 (13%)
Query: 1146 VQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKA----------- 1194
+ Q P+ L+ + EN GDN V +++ A+A H I+ L +A
Sbjct: 821 IAQLPLKLESEVMEN---GDNF-SVGERQLLCIARALLRHCKILILDEATAAMDTETDLL 876
Query: 1195 VTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVS 1243
+ E + +A T + IAHRL TV +D I V+ +G++VE T + L+S
Sbjct: 877 IQETIREAFADCTMLNIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLS 925
Score = 33.9 bits (74), Expect = 3.7
Identities = 13/31 (41%), Positives = 22/31 (70%)
Query: 1079 QRVLKGIDLKMEAGKTIALVGSSGCGKSTIL 1109
QR L IDL+++ GK + + GS G GK++++
Sbjct: 84 QRTLHSIDLEIQEGKLVGICGSVGSGKTSLI 114
>AY851364-1|AAW31629.1| 131|Homo sapiens ABCB5alpha protein.
Length = 131
Score = 131 bits (316), Expect = 2e-29
Identities = 64/109 (58%), Positives = 82/109 (75%)
Query: 469 RSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGE 528
R +GVV QEPVLF TI +NI G + T EE++R A A A+DFI PN ++T++GE
Sbjct: 16 RDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDFIMEFPNKFNTLVGE 75
Query: 529 RGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDR 577
+GA +SGGQKQRIAIAR+L+R P +L+LDEATSALD SE VQAAL++
Sbjct: 76 KGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESESAVQAALEK 124
Score = 53.6 bits (123), Expect = 4e-06
Identities = 34/81 (41%), Positives = 47/81 (58%), Gaps = 4/81 (4%)
Query: 1125 LDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANI 1184
+D DIR AL + R +GVV QEPVL +++ NI YG ++ VT E+ AA+ AN
Sbjct: 2 VDENDIR-ALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDD--VTDEEMERAAREANA 58
Query: 1185 HSFIVSLP-KAVTEALEKAAK 1204
+ FI+ P K T EK A+
Sbjct: 59 YDFIMEFPNKFNTLVGEKGAQ 79
>AF352582-1|AAK19755.1| 1382|Homo sapiens ATP-binding cassette
transporter MRP8 protein.
Length = 1382
Score = 131 bits (316), Expect = 2e-29
Identities = 76/231 (32%), Positives = 121/231 (52%), Gaps = 2/231 (0%)
Query: 392 GDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAG 451
G+I+ +D Y VL G ++ ++ E V +VG +G GKS++ L RL +P AG
Sbjct: 1139 GEIIFQDYHMKYRDNTPT-VLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAG 1197
Query: 452 SVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYA 511
+ LRS L V+ Q+PVL GTI N+ T ++I E +
Sbjct: 1198 RILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLD-PFDRHTDQQIWDALERTFL 1256
Query: 512 HDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV 571
IS P T + E G + S G++Q + IAR++LR ++L+DEAT+++D ++ +
Sbjct: 1257 TKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETDTLI 1316
Query: 572 QAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKG 622
Q + A G T + ++HR++T++N DRI+ M G +VE E L K G
Sbjct: 1317 QRTIREAFQGCTVLVIAHRVTTVLNCDRILVMGNGKVVEFDRPEVLRKKPG 1367
Score = 107 bits (256), Expect = 3e-22
Identities = 69/218 (31%), Positives = 115/218 (52%), Gaps = 15/218 (6%)
Query: 412 LKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSS 471
L ++ V G + + G++G GKS++L + GSV ++ S
Sbjct: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVG-------------VQGS 573
Query: 472 LGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGA 531
L V Q+ + G I +NI +G +Q + + D + LLP G T IGERG
Sbjct: 574 LAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRD-LELLPFGDMTEIGERGP 632
Query: 532 SLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVSHR 590
+LSGGQKQRI++AR++ + + LLD+ SA+D H + + + + + G+T + V+H+
Sbjct: 633 NLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVQVTHQ 692
Query: 591 LSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLV 628
L + ++I ++ G I E GTH +LM+ KG Y +L+
Sbjct: 693 LQYLEFCGQVILLENGKICENGTHSELMQKKGKYAQLI 730
Score = 63.7 bits (148), Expect = 4e-09
Identities = 88/414 (21%), Positives = 173/414 (41%), Gaps = 25/414 (6%)
Query: 796 ISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQG 855
+ +C S FT K +T L ++ F + + + FFD T +G + +GD ++
Sbjct: 876 VGVC-SSGIFTKVTRKASTALHNKLFNKVFRCPMSFFD--TIPIGRLLNCFAGDLEQLDQ 932
Query: 856 ATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDER 915
+ L +S +V+ LL +S L+ + ++ ++ + + + +R
Sbjct: 933 LLPIFSEQFLV-LSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYM--MFKEAIGVFKR 989
Query: 916 NAMESATAIATEAVVSIKTVQSL---GVETVFLQKFQ---DALKTACVAVAYKTRWRGLV 969
S + + + + S++ + S+ G F+ +F+ DA + TRW L
Sbjct: 990 LENYSRSPLFSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALR 1049
Query: 970 YGLGVYIPFMAYCSATVYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLV--YAPSLN 1027
+ + +A +G Y +K V+ VN + + + + +
Sbjct: 1050 LEIMTNLVTLAVALFVAFGISSTPYS---FK-VMAVNIVLQLASSFQATARIGLETEAQF 1105
Query: 1028 TAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDL 1087
TA + + + + +H G + W G +D Y + VL GI+L
Sbjct: 1106 TAVERILQYMKMCVSEAPLHME-GTSCPQGWPQHGEIIFQDYHMKYRDN-TPTVLHGINL 1163
Query: 1088 KMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQ 1147
+ + + +VG +G GKS++ R +P +G I +D DI S + + LR +L V+
Sbjct: 1164 TIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICS-IGLEDLRSKLSVIP 1222
Query: 1148 QEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAV-TEALE 1200
Q+PVLL ++ N+ D + T +I A + + I PK + T+ +E
Sbjct: 1223 QDPVLLSGTIRFNLDPFDRH---TDQQIWDALERTFLTKAISKFPKKLHTDVVE 1273
Score = 48.4 bits (110), Expect = 2e-04
Identities = 18/52 (34%), Positives = 33/52 (63%)
Query: 1197 EALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHY 1248
E ++K +G+T + + H+L ++ + +++ GKI E GTH+EL+ KG Y
Sbjct: 675 ECIKKTLRGKTVVQVTHQLQYLEFCGQVILLENGKICENGTHSELMQKKGKY 726
Score = 37.1 bits (82), Expect = 0.40
Identities = 16/40 (40%), Positives = 26/40 (65%)
Query: 1195 VTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVE 1234
+ + +A +G T + IAHR++TV + D I V+ GK+VE
Sbjct: 1316 IQRTIREAFQGCTVLVIAHRVTTVLNCDRILVMGNGKVVE 1355
>AY040219-1|AAK76739.1| 1382|Homo sapiens ATP-binding cassette
transporter sub-family C member 11 protein.
Length = 1382
Score = 129 bits (311), Expect = 7e-29
Identities = 75/231 (32%), Positives = 120/231 (51%), Gaps = 2/231 (0%)
Query: 392 GDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAG 451
G+I+ +D Y VL G ++ ++ E V +VG +G GKS++ L RL +P AG
Sbjct: 1139 GEIIFQDYHMKYRDNTPT-VLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAG 1197
Query: 452 SVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYA 511
+ LRS L V+ Q+PVL GTI N+ T ++I E +
Sbjct: 1198 RILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLD-PFDRHTDQQIWDALERTFL 1256
Query: 512 HDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV 571
IS P T + E G + S G++Q + IAR++LR ++L+DEAT+++D ++ +
Sbjct: 1257 TKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETDTLI 1316
Query: 572 QAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKG 622
Q + A G T + ++HR++T++N D I+ M G +VE E L K G
Sbjct: 1317 QRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPG 1367
Score = 107 bits (257), Expect = 2e-22
Identities = 70/218 (32%), Positives = 115/218 (52%), Gaps = 15/218 (6%)
Query: 412 LKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSS 471
L ++ V G + + G++G GKS++L + GSV ++ S
Sbjct: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVG-------------VQGS 573
Query: 472 LGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGA 531
L V Q+ + G I +NI +G +Q + + D + LLP G T IGERG
Sbjct: 574 LAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRD-LELLPFGDMTEIGERGL 632
Query: 532 SLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVSHR 590
+LSGGQKQRI++AR++ + + LLD+ SA+D H + + + + + G+T + V+H+
Sbjct: 633 NLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQ 692
Query: 591 LSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLV 628
L + +II ++ G I E GTH +LM+ KG Y +L+
Sbjct: 693 LQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI 730
Score = 63.7 bits (148), Expect = 4e-09
Identities = 87/413 (21%), Positives = 171/413 (41%), Gaps = 23/413 (5%)
Query: 796 ISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQG 855
+ +C S FT K +T L ++ F + + + FFD T +G + +GD ++
Sbjct: 876 VGVC-SSGIFTKVTRKASTALHNKLFNKVFRCPMSFFD--TIPIGRLLNCFAGDLEQLDQ 932
Query: 856 ATGLRIGLILQGISSVVVGFLLAISY--NWKLTLVATVFLPLMVGSIWLEGIISQKAQID 913
+ L +S +V+ LL +S + L + A + + + + + I +++
Sbjct: 933 LLPIFSEQFLV-LSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLE 991
Query: 914 ERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQ---DALKTACVAVAYKTRWRGLVY 970
+ + I ++ + ++ G F+ +F+ DA + TRW L
Sbjct: 992 NYSRSPLFSHILN-SLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRL 1050
Query: 971 GLGVYIPFMAYCSATVYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLV--YAPSLNT 1028
+ + +A +G Y +K V+ VN + + + + + T
Sbjct: 1051 EIMTNLVTLAVALFVAFGISSTPYS---FK-VMAVNIVLQLASSFQATARIGLETEAQFT 1106
Query: 1029 AKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLK 1088
A + + + + +H G + W G +D Y + VL GI+L
Sbjct: 1107 AVERILQYMKMCVSEAPLHME-GTSCPQGWPQHGEIIFQDYHMKYRDN-TPTVLHGINLT 1164
Query: 1089 MEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQ 1148
+ + + +VG +G GKS++ R +P +G I +D DI S + + LR +L V+ Q
Sbjct: 1165 IRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICS-IGLEDLRSKLSVIPQ 1223
Query: 1149 EPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAV-TEALE 1200
+PVLL ++ N+ D + T +I A + + I PK + T+ +E
Sbjct: 1224 DPVLLSGTIRFNLDPFDRH---TDQQIWDALERTFLTKAISKFPKKLHTDVVE 1273
Score = 48.8 bits (111), Expect = 1e-04
Identities = 19/52 (36%), Positives = 33/52 (63%)
Query: 1197 EALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHY 1248
E ++K +G+T + + H+L ++ I +++ GKI E GTH+EL+ KG Y
Sbjct: 675 ECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKY 726
Score = 36.7 bits (81), Expect = 0.53
Identities = 16/40 (40%), Positives = 26/40 (65%)
Query: 1195 VTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVE 1234
+ + +A +G T + IAHR++TV + D I V+ GK+VE
Sbjct: 1316 IQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVE 1355
>AF367202-1|AAK58869.1| 1382|Homo sapiens ATP-binding cassette protein
C11 protein.
Length = 1382
Score = 129 bits (311), Expect = 7e-29
Identities = 75/231 (32%), Positives = 120/231 (51%), Gaps = 2/231 (0%)
Query: 392 GDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAG 451
G+I+ +D Y VL G ++ ++ E V +VG +G GKS++ L RL +P AG
Sbjct: 1139 GEIIFQDYHMKYRDNTPT-VLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAG 1197
Query: 452 SVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYA 511
+ LRS L V+ Q+PVL GTI N+ T ++I E +
Sbjct: 1198 RILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLD-PFDRHTDQQIWDALERTFL 1256
Query: 512 HDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV 571
IS P T + E G + S G++Q + IAR++LR ++L+DEAT+++D ++ +
Sbjct: 1257 TKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETDTLI 1316
Query: 572 QAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKG 622
Q + A G T + ++HR++T++N D I+ M G +VE E L K G
Sbjct: 1317 QRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPG 1367
Score = 107 bits (257), Expect = 2e-22
Identities = 70/218 (32%), Positives = 115/218 (52%), Gaps = 15/218 (6%)
Query: 412 LKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSS 471
L ++ V G + + G++G GKS++L + GSV ++ S
Sbjct: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVG-------------VQGS 573
Query: 472 LGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGA 531
L V Q+ + G I +NI +G +Q + + D + LLP G T IGERG
Sbjct: 574 LAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRD-LELLPFGDMTEIGERGL 632
Query: 532 SLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVSHR 590
+LSGGQKQRI++AR++ + + LLD+ SA+D H + + + + + G+T + V+H+
Sbjct: 633 NLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQ 692
Query: 591 LSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLV 628
L + +II ++ G I E GTH +LM+ KG Y +L+
Sbjct: 693 LQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI 730
Score = 63.7 bits (148), Expect = 4e-09
Identities = 87/413 (21%), Positives = 171/413 (41%), Gaps = 23/413 (5%)
Query: 796 ISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQG 855
+ +C S FT K +T L ++ F + + + FFD T +G + +GD ++
Sbjct: 876 VGVC-SSGIFTKVTRKASTALHNKLFNKVFRCPMSFFD--TIPIGRLLNCFAGDLEQLDQ 932
Query: 856 ATGLRIGLILQGISSVVVGFLLAISY--NWKLTLVATVFLPLMVGSIWLEGIISQKAQID 913
+ L +S +V+ LL +S + L + A + + + + + I +++
Sbjct: 933 LLPIFSEQFLV-LSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLE 991
Query: 914 ERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQ---DALKTACVAVAYKTRWRGLVY 970
+ + I ++ + ++ G F+ +F+ DA + TRW L
Sbjct: 992 NYSRSPLFSHILN-SLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRL 1050
Query: 971 GLGVYIPFMAYCSATVYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLV--YAPSLNT 1028
+ + +A +G Y +K V+ VN + + + + + T
Sbjct: 1051 EIMTNLVTLAVALFVAFGISSTPYS---FK-VMAVNIVLQLASSFQATARIGLETEAQFT 1106
Query: 1029 AKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLK 1088
A + + + + +H G + W G +D Y + VL GI+L
Sbjct: 1107 AVERILQYMKMCVSEAPLHME-GTSCPQGWPQHGEIIFQDYHMKYRDN-TPTVLHGINLT 1164
Query: 1089 MEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQ 1148
+ + + +VG +G GKS++ R +P +G I +D DI S + + LR +L V+ Q
Sbjct: 1165 IRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICS-IGLEDLRSKLSVIPQ 1223
Query: 1149 EPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAV-TEALE 1200
+PVLL ++ N+ D + T +I A + + I PK + T+ +E
Sbjct: 1224 DPVLLSGTIRFNLDPFDRH---TDQQIWDALERTFLTKAISKFPKKLHTDVVE 1273
Score = 48.8 bits (111), Expect = 1e-04
Identities = 19/52 (36%), Positives = 33/52 (63%)
Query: 1197 EALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHY 1248
E ++K +G+T + + H+L ++ I +++ GKI E GTH+EL+ KG Y
Sbjct: 675 ECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKY 726
Score = 36.7 bits (81), Expect = 0.53
Identities = 16/40 (40%), Positives = 26/40 (65%)
Query: 1195 VTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVE 1234
+ + +A +G T + IAHR++TV + D I V+ GK+VE
Sbjct: 1316 IQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVE 1355
>BC017348-1|AAH17348.1| 596|Homo sapiens ABCB9 protein protein.
Length = 596
Score = 126 bits (304), Expect = 5e-28
Identities = 102/360 (28%), Positives = 165/360 (45%), Gaps = 22/360 (6%)
Query: 781 DLYSVLFVVIAAVA-GISMC--LQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETN 837
D +S V++ +A G S ++ FT ++ RLR+ F SL+ QE FFD+ N
Sbjct: 223 DQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDE--N 280
Query: 838 TVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLMV 897
G + +RL+ DT V I + L+ V + S +W+L+LV + P+++
Sbjct: 281 RTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIM 340
Query: 898 GSIWLEGIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVET----VFLQKFQDALK 953
+ G ++ + +NA+ A+ A E + ++KTV+S E V+L+K Q K
Sbjct: 341 MVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYK 400
Query: 954 -TACVAVAYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEY-KLVLLVNEAIMY 1011
A AY V+G G+ + + S YG LV G+M L+ + +
Sbjct: 401 LNRKEAAAYMY----YVWGSGLTL-LVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVL 455
Query: 1012 GAYMLGQSLVYAPSLNTAKACGARILSIIQRQPK-IHNAVGVKDKKDWVASGNFSMRDVE 1070
G M VY+ L ++ I RQP +H+ D + G +V
Sbjct: 456 GDCMESVGSVYS-GLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLE----GRVDFENVT 510
Query: 1071 FCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDI 1130
F Y TRP +VL+ + + GK ALVG SG GKS+ + + + FY + G + LD + I
Sbjct: 511 FTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPI 570
Score = 113 bits (273), Expect = 3e-24
Identities = 80/318 (25%), Positives = 148/318 (46%), Gaps = 18/318 (5%)
Query: 140 RIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAV-VSNLVGTSVICL 198
R+R RS++ Q+ S++D + +L S+++ + + + + + + V + N V + + +
Sbjct: 260 RLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVV 319
Query: 199 CTAFPLGWQLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTI 258
F L WQL+L P ++ S Y + S + + A AEE + +++T+
Sbjct: 320 FM-FSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTV 378
Query: 259 VAFGGENKEVERYRRLLEPAEEFGRKRG---LFTGLGNGFNWVLTYSLNAIGFSYGTRLV 315
+F E +E E Y R L+ + RK ++ G+G +L ++ + YG LV
Sbjct: 379 RSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLT-LLVVQVSIL--YYGGHLV 435
Query: 316 VNDFDTDSNLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREP 375
++ T NL + +Y + M + + G +F I+R+P
Sbjct: 436 ISGQMTSGNLIAF---IIYEFVLGDCMESVGSVY-----SGLMQGVGAAEKVFEFIDRQP 487
Query: 376 KIDSLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGK 435
+ + L P + G + E+V F Y +RP +VL+ S + PG+ ALVG SG GK
Sbjct: 488 TM--VHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGK 545
Query: 436 STVLQLLQRLYDPQAGSV 453
S+ + +L+ Y + G V
Sbjct: 546 SSCVNILENFYPLEGGRV 563
>L40625-1|AAA99227.1| 395|Homo sapiens sulfonylurea receptor
protein.
Length = 395
Score = 124 bits (299), Expect = 2e-27
Identities = 84/299 (28%), Positives = 144/299 (48%), Gaps = 5/299 (1%)
Query: 326 RQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPK-IDSLQQKG 384
R+ G V L M + + + V +L I L++ E + + L
Sbjct: 87 RELSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLLKTEAESYEGLLAPS 146
Query: 385 LTPRRVV--GDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLL 442
L P+ G I ++++ Y S + VLK + + PG+ + + G +G GKS+
Sbjct: 147 LIPKNWPDQGKIQIQNLSVRYDSSLK-PVLKHVNALISPGQKIGICGRTGSGKSSFSLAF 205
Query: 443 QRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEI 502
R+ D G + LRS L ++ Q+PVLF GTI N+ + + +
Sbjct: 206 FRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLD-PERKCSDSTL 264
Query: 503 QRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSA 562
EIA + LP G D +I E G + S GQ+Q +AR+ +R+ ++ ++DEAT++
Sbjct: 265 WEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATAS 324
Query: 563 LDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAK 621
+D +E +Q + A RT +T++HR+ TI++AD +I + +G I+E E L+ K
Sbjct: 325 IDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRK 383
Score = 59.7 bits (138), Expect = 7e-08
Identities = 69/309 (22%), Positives = 134/309 (43%), Gaps = 26/309 (8%)
Query: 911 QIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQK---FQDALKTACVAVAYKTRWRG 967
Q+D+ + + A E V + T+++ E F QK + D+ A + + RW
Sbjct: 4 QLDDTTQLPLLSHFA-ETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRW-- 60
Query: 968 LVYGLGVYIPFMAYCSATVYGAVLVA---YGEMEYKLVLL-VNEAIMYGAYMLGQSLVYA 1023
L V + ++ C + ++ + E+ LV L + A+M Y L +
Sbjct: 61 ----LEVRMEYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTYALMVSNY-LNWMVRNL 115
Query: 1024 PSLNTAKACGARILSIIQRQPKIHNAVGVKD--KKDWVASGNFSMRDVEFCYPTRPSQRV 1081
+ RI +++ + + + + K+W G ++++ Y + + V
Sbjct: 116 ADMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSS-LKPV 174
Query: 1082 LKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRR 1141
LK ++ + G+ I + G +G GKS+ F R D G I +D DI + L + LR
Sbjct: 175 LKHVNALISPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDI-AKLPLHTLRS 233
Query: 1142 QLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP----KAVTE 1197
+L ++ Q+PVL ++ N+ D RK + + A + A + + +LP +TE
Sbjct: 234 RLSIILQDPVLFSGTIRFNL---DPERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITE 290
Query: 1198 ALEKAAKGR 1206
E ++G+
Sbjct: 291 GGENFSQGQ 299
Score = 39.9 bits (89), Expect = 0.056
Identities = 27/91 (29%), Positives = 40/91 (43%), Gaps = 4/91 (4%)
Query: 1159 ENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAVTEALEK----AAKGRTCITIAHR 1214
EN + G V + S+ A L+K A RT +TIAHR
Sbjct: 293 ENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHR 352
Query: 1215 LSTVKDADLICVIDKGKIVERGTHAELVSMK 1245
+ T+ ADL+ V+ +G I+E +L+S K
Sbjct: 353 VHTILSADLVIVLKRGAILEFDKPEKLLSRK 383
>AY490254-1|AAR99172.1| 164|Homo sapiens P-glycoprotein protein.
Length = 164
Score = 124 bits (299), Expect = 2e-27
Identities = 68/148 (45%), Positives = 92/148 (62%), Gaps = 20/148 (13%)
Query: 1062 GNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSG 1121
GN R+V F YP+R ++LKG++LK+++G+T+ALVG+SGCGKST +QL QR YDP G
Sbjct: 19 GNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEG 78
Query: 1122 F-----------------IELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYG 1164
+ +D +DIR+ + + LR +GVV QEPVL ++AENI YG
Sbjct: 79 MLPFQLQMYESHTYFLFQVSVDGQDIRT-INVRFLREIIGVVSQEPVLFATTIAENIRYG 137
Query: 1165 DNNRKVTMHEIVAAAKAANIHSFIVSLP 1192
N VTM EI A K AN + FI+ LP
Sbjct: 138 REN--VTMDEIEKAVKEANAYDFIMKLP 163
Score = 124 bits (298), Expect = 3e-27
Identities = 69/164 (42%), Positives = 92/164 (56%), Gaps = 17/164 (10%)
Query: 374 EPKIDSLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGC 433
+P IDS + G P + G++ +V F YPSR EVK+LKG ++ V+ G+ VALVG+SGC
Sbjct: 1 KPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGC 60
Query: 434 GKSTVLQLLQRLYDPQAG-----------------SVXXXXXXXXXXXXSWLRSSLGVVG 476
GKST +QL+QRLYDP G V +LR +GVV
Sbjct: 61 GKSTTVQLMQRLYDPTEGMLPFQLQMYESHTYFLFQVSVDGQDIRTINVRFLREIIGVVS 120
Query: 477 QEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPN 520
QEPVLF TI +NI G T +EI++ + A A+DFI LP+
Sbjct: 121 QEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPH 164
>AJ294545-1|CAC69553.1| 1514|Homo sapiens multidrug resistance
associated protein protein.
Length = 1514
Score = 124 bits (299), Expect = 2e-27
Identities = 121/527 (22%), Positives = 238/527 (45%), Gaps = 38/527 (7%)
Query: 107 AMAIGMFISIGVSLVFCVLSFSLISWSALRQITRI-RTLFLRSVLRQDMSWYDTDSEFNL 165
++ +G++ ++G+ F V+ ++ + Q R+ L + +R S++DT +
Sbjct: 1009 SLRLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRI 1068
Query: 166 ASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPLGWQLTLACAAVMPFSVITSIA 225
+ S+++ + E + + ++ N ++ L L ++P +V+ ++
Sbjct: 1069 LNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMA---STPLFTVVILPLAVLYTLV 1125
Query: 226 LSNYQ-TKSSIREMESYSLAG--KQAEEILKSVRTIVAFGGENKEVERYRRLLEPAEEFG 282
Y T ++ +ES S + E + I A+ +++ E ++ +
Sbjct: 1126 QRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYN-RSRDFE----IISDTKVDA 1180
Query: 283 RKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVYSILFSVYM 342
+R + + + W L+ + +G + S+L VG S V
Sbjct: 1181 NQRSCYPYIISN-RW-LSIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTF 1238
Query: 343 ATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKI--DSLQQKGLTPRRVVGDILLEDVE 400
A + + LE P + S +G PR G++ +
Sbjct: 1239 ALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPR---GEVEFRNYS 1295
Query: 401 FCYPSRPEVK-VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXX 459
Y RP + VL+ S+HV GE V +VG +G GKS++ L R+ + G +
Sbjct: 1296 VRY--RPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGL- 1352
Query: 460 XXXXXXSWLRSSLGVVGQEPVLFRGTIYDNI-AIGSPEATREEIQRVAEIAYAHDFISLL 518
++ +G +P+LF GT+ N+ GS + E+I E+++ H F+S
Sbjct: 1353 -----------NVADIG-DPILFSGTLRMNLDPFGS--YSEEDIWWALELSHLHTFVSSQ 1398
Query: 519 PNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRA 578
P G D E G +LS GQ+Q + +AR+LLR+ +L+LDEAT+A+D ++ +QA +
Sbjct: 1399 PAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQ 1458
Query: 579 SVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYH 625
T +T++HRL+TI++ R++ +D+GV+ E + +L+ A+G ++
Sbjct: 1459 FDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIFY 1505
Score = 97.1 bits (231), Expect = 4e-19
Identities = 69/260 (26%), Positives = 121/260 (46%), Gaps = 21/260 (8%)
Query: 412 LKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSS 471
L I V G VA+VG GCGKS+++ L + G V ++ S
Sbjct: 644 LHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVH-------------MKGS 690
Query: 472 LGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGA 531
+ V Q+ + T+ +N+ G + Q + A D + +LP G T IGE+G
Sbjct: 691 VAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLAD-LEMLPGGDQTEIGEKGI 749
Query: 532 SLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV---QAALDRASVGRTTITVS 588
+LSGGQ+QR+++AR++ + + LLD+ SA+D H + + + G+T + V+
Sbjct: 750 NLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVT 809
Query: 589 HRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENKEPADIEPLIEEAD 648
H +S + D II + G + E G + L++ G + + +++ +E +
Sbjct: 810 HGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTALE 869
Query: 649 GDGDN----IEPTVPSRLDV 664
G D IE T+ + D+
Sbjct: 870 GAEDKEALLIEDTLSNHTDL 889
Score = 57.6 bits (133), Expect = 3e-07
Identities = 106/515 (20%), Positives = 194/515 (37%), Gaps = 56/515 (10%)
Query: 786 LFVVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICAR 845
++ + + G + L + + G++ L + ++ FFD T G I
Sbjct: 1014 VYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFD--TTPSGRILNC 1071
Query: 846 LSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLMVGSIWLEGI 905
S D V I ++L + + ++ ++ L V LPL V ++
Sbjct: 1072 FSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMA---STPLFTVVILPLAVLYTLVQRF 1128
Query: 906 ISQKAQIDERNAMESATAIAT---EAVVSIKTVQSLGVETVF---LQKFQDALKTACVAV 959
+ ++ +R S + I + E V +++ F DA + +C
Sbjct: 1129 YAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPY 1188
Query: 960 AYKTRWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEYK--LVLLVNEAIMYGAYMLG 1017
RW L + + F+ C ++ A+ G LV L + + L
Sbjct: 1189 IISNRW------LSIGVEFVGNC-VVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALN 1241
Query: 1018 QSLVYAPSLNTAKACGARILSIIQRQPKIHNAV-GVKDKKDWVASGNFSMRDVEFCYPTR 1076
+ L + R+ + + + V G + + W G R+ Y R
Sbjct: 1242 WMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRY--R 1299
Query: 1077 PS-QRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSA-- 1133
P VL+ + L + G+ + +VG +G GKS++ R + G I +D ++
Sbjct: 1300 PGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGD 1359
Query: 1134 --LTIPRLRRQL---GVVQQEPVLLDRSLAE--------------NIAYGDNNRKVTMHE 1174
L LR L G +E + L+ + G N V +
Sbjct: 1360 PILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQ 1419
Query: 1175 IVAAAKAANIHSFIVSLPKAV------TEALEKAA---KGRTC--ITIAHRLSTVKDADL 1223
+V A+A S I+ L +A T+ L +A + TC +TIAHRL+T+ D
Sbjct: 1420 LVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTR 1479
Query: 1224 ICVIDKGKIVERGTHAELVSMKGHYWRMCRGQNMA 1258
+ V+DKG + E + A L++ +G ++ M R +A
Sbjct: 1480 VLVLDKGVVAEFDSPANLIAARGIFYGMARDAGLA 1514
>AL122095-1|CAB59263.1| 216|Homo sapiens hypothetical protein
protein.
Length = 216
Score = 121 bits (292), Expect = 1e-26
Identities = 63/184 (34%), Positives = 108/184 (58%), Gaps = 2/184 (1%)
Query: 427 LVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTI 486
+VG +G GKS++L +L RL +P +G V + LRS L ++ QEP LF GT+
Sbjct: 2 IVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSGTV 61
Query: 487 YDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARS 546
+N+ R Q + + + S+ G D +GE G SLS GQ+Q + +AR+
Sbjct: 62 RENLDPQGLHKDRALWQALKQCHLSEVITSM--GGLDGELGEGGRSLSLGQRQLLCLARA 119
Query: 547 LLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMDQG 606
LL + +L +DEAT+++D +++ +Q + + +T +T++HRL+TI+N+DR++ + G
Sbjct: 120 LLTDAKILCIDEATASVDQKTDQLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAG 179
Query: 607 VIVE 610
+VE
Sbjct: 180 RVVE 183
Score = 54.8 bits (126), Expect = 2e-06
Identities = 38/142 (26%), Positives = 71/142 (50%), Gaps = 4/142 (2%)
Query: 1097 LVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRS 1156
+VG +G GKS++L + R +P SG + LD D S L + +LR QL ++ QEP L +
Sbjct: 2 IVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVD-TSQLELAQLRSQLAIIPQEPFLFSGT 60
Query: 1157 LAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAVTEALEKAAKG-RTCITIAHRL 1215
+ EN+ ++ + + + + + + + L + E + G R + +A L
Sbjct: 61 VRENLDPQGLHKDRALWQALKQCHLSEVITSMGGLDGELGEGGRSLSLGQRQLLCLARAL 120
Query: 1216 STVKDADLICVIDKGKIVERGT 1237
T DA ++C+ + V++ T
Sbjct: 121 LT--DAKILCIDEATASVDQKT 140
Score = 37.5 bits (83), Expect = 0.30
Identities = 26/96 (27%), Positives = 46/96 (47%), Gaps = 7/96 (7%)
Query: 1153 LDRSLAE---NIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAVTEALE----KAAKG 1205
LD L E +++ G ++ AK I S+ + + L+ K
Sbjct: 95 LDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRFAN 154
Query: 1206 RTCITIAHRLSTVKDADLICVIDKGKIVERGTHAEL 1241
+T +TIAHRL+T+ ++D + V+ G++VE + A L
Sbjct: 155 KTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATL 190
>AF022853-2|AAB83983.1| 1450|Homo sapiens multidrug resistance
protein protein.
Length = 1450
Score = 119 bits (287), Expect = 6e-26
Identities = 124/550 (22%), Positives = 242/550 (44%), Gaps = 33/550 (6%)
Query: 102 IDDAKAMAI-GMFISIGVSLVFCVLSFSLISWSALRQIT--RIRTLFLRSVLRQDMSWYD 158
++D KA G F ++ + + C+ + L + + ++ RI+T + +V R+ + +
Sbjct: 337 VNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITN 396
Query: 159 TDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPLGW----QLTLACAA 214
+ + + ++ NLMS+ LA N++ ++ + + A L W LA A
Sbjct: 397 SARKSSTVGEIV-NLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVA 455
Query: 215 VMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAFGGENKEVERYRRL 274
VM V + ++ + M+S K EIL ++ + + E ++ +
Sbjct: 456 VMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAI 515
Query: 275 LEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVY 334
+ + +K + +G F WV T L A+ ++ + +++ +N+ V
Sbjct: 516 RQEELKVLKKSAYLSAVGT-FTWVCTPFLVAL-CTFAVYVTIDE----NNILDAQTAFVS 569
Query: 335 SILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPRRVVGDI 394
LF++ +I V IF L E + DS++++ + I
Sbjct: 570 LALFNILRFPLNILPMVISSIVQASVSLKRLRIF-LSHEELEPDSIERRPVKDGGGTNSI 628
Query: 395 LLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVX 454
+ + F + +R + L G + + G VA+VG GCGKS++L L D G V
Sbjct: 629 TVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVA 687
Query: 455 XXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDF 514
++ S+ V Q+ + ++ +NI G + + V +
Sbjct: 688 -------------IKGSVAYVPQQAWIQNDSLRENILFGC-QLEEPYYRSVIQACALLPD 733
Query: 515 ISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QA 573
+ +LP+G T IGE+G +LSGGQKQR+++AR++ + L D+ SA+D H + + +
Sbjct: 734 LEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFEN 793
Query: 574 ALDRASV--GRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTG 631
+ + +T I V+H +S + D II M G I E G++++L+ G + + + T
Sbjct: 794 VIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTY 853
Query: 632 NENKEPADIE 641
++ D E
Sbjct: 854 ASTEQEQDAE 863
Score = 67.7 bits (158), Expect = 2e-10
Identities = 96/431 (22%), Positives = 179/431 (41%), Gaps = 23/431 (5%)
Query: 110 IGMFISIGVSLVFCVLSFSL-ISWSALRQITRIRTLFLRSVLRQDMSWYDTDSEFNLASK 168
+ ++ ++G+S V +S+ +S + + L S+LR MS+++ NL ++
Sbjct: 1000 LSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNR 1059
Query: 169 MSENLMSIKEGMGEKLAVVSNLVGT--SVICLCTAFPLGWQLTLACAAVMPFSVITSIAL 226
S+ L ++ + E V+ +G+ +VI C L +A + P +I
Sbjct: 1060 FSKELDTVDSMIPE---VIKMFMGSLFNVIGACIVILLA--TPIAAIIIPPLGLIYFFVQ 1114
Query: 227 SNYQTKS-SIREMESYSLAGKQAE--EILKSVRTIVAFGGENKEVERYRRLLEPAEEFGR 283
Y S ++ +ES S + + E L V I AF +E ER+ + + +
Sbjct: 1115 RFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAF----EEQERFIHQSDLKVDENQ 1170
Query: 284 KRGLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVYSILFSVYMA 343
K + + N W L L +G + + +L VG S+ +S+ +
Sbjct: 1171 KAYYPSIVAN--RW-LAVRLECVGNCIVLFAALFAVISRHSLSAGLVGL--SVSYSLQVT 1225
Query: 344 TQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPRRVVGDILLEDVEFCY 403
T + + V + E E + Q+ P +E +C
Sbjct: 1226 TY-LNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCL 1284
Query: 404 PSRPEVK-VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXX 462
R ++ VL+ ++ + GE V +VG +G GKS++ L R+ + G +
Sbjct: 1285 RYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAK 1344
Query: 463 XXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGY 522
LR + ++ Q+PVLF G++ N+ S + + EE+ E+A+ DF+S LP+
Sbjct: 1345 IGLHDLRFKITIIPQDPVLFSGSLRMNLDPFS-QYSDEEVWTSLELAHLKDFVSALPDKL 1403
Query: 523 DTVIGERGASL 533
D E G +L
Sbjct: 1404 DHECAEGGENL 1414
Score = 54.4 bits (125), Expect = 2e-06
Identities = 47/197 (23%), Positives = 94/197 (47%), Gaps = 23/197 (11%)
Query: 1058 WVASGNFSMRDVEFCYPTRPS-QRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFY 1116
W G R+ +C R VL+ I++ + G+ + +VG +G GKS++ R
Sbjct: 1271 WPQVGRVEFRN--YCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRIN 1328
Query: 1117 DPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIV 1176
+ G I +D +I + + + LR ++ ++ Q+PVL SL N+ D + + E+
Sbjct: 1329 ESAEGEIIIDGINI-AKIGLHDLRFKITIIPQDPVLFSGSLRMNL---DPFSQYSDEEVW 1384
Query: 1177 AAAKAANIHSFIVSLPKAVTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERG 1236
+ + A++ F+ +LP + + A+G + + V+DKG+I E G
Sbjct: 1385 TSLELAHLKDFVSALPDKLD---HECAEGGENLR-------------VIVLDKGEIQEYG 1428
Query: 1237 THAELVSMKGHYWRMCR 1253
++L+ +G ++ M +
Sbjct: 1429 APSDLLQQRGLFYSMAK 1445
Score = 39.9 bits (89), Expect = 0.056
Identities = 59/295 (20%), Positives = 114/295 (38%), Gaps = 8/295 (2%)
Query: 834 KETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFL 893
++++TVG I +S D I +I V++ L L +
Sbjct: 399 RKSSTVGEIVNLMSVDAQRFMDLATY-INMIWSAPLQVILALYLLWLNLGPSVLAGVAVM 457
Query: 894 PLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQDALK 953
LMV + + ++ Q+ + ++ + E + IK ++ E F K A++
Sbjct: 458 VLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVL-AIR 516
Query: 954 TACVAVAYKTRWRGLVYGLG-VYIPFM-AYCSATVYGAVLVAYGEMEYKLVLLVNEAIM- 1010
+ V K+ + V V PF+ A C+ VY V + + V+ A+
Sbjct: 517 QEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVY--VTIDENNILDAQTAFVSLALFN 574
Query: 1011 YGAYMLGQSLVYAPSLNTAKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVE 1070
+ L + S+ A R+ + + +++ + KD + + ++R+
Sbjct: 575 ILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNAT 634
Query: 1071 FCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIEL 1125
F + R L GI + G +A+VG GCGKS++L D G + +
Sbjct: 635 FTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAI 688
Score = 36.7 bits (81), Expect = 0.53
Identities = 17/50 (34%), Positives = 28/50 (56%)
Query: 1204 KGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRMCR 1253
K +T I + H +S + D+I V+ GKI E G++ EL++ G + R
Sbjct: 802 KNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLR 851
>AY196326-1|AAO40749.1| 930|Homo sapiens truncated ABCC12 protein
protein.
Length = 930
Score = 119 bits (286), Expect = 8e-26
Identities = 74/230 (32%), Positives = 122/230 (53%), Gaps = 17/230 (7%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
VL S V+ G+ + + G+ G GKS++L L Q G V +
Sbjct: 437 VLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVA-------------VNG 483
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
+L V Q+ +F G + +NI G + + Q + +S LP G T IGERG
Sbjct: 484 TLAYVSQQAWIFHGNVRENILFGE-KYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERG 542
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVSH 589
+LSGGQ+QRI++AR++ + + LLD+ SA+D H + V + + + G+T + V+H
Sbjct: 543 LNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLVTH 602
Query: 590 RLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLV--TTGNENKEP 637
+L + + D +I ++ G I E+GTH++LM+ +G Y KL+ G + K+P
Sbjct: 603 QLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDP 652
Score = 49.2 bits (112), Expect = 9e-05
Identities = 17/55 (30%), Positives = 36/55 (65%)
Query: 1197 EALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRM 1251
E ++K +G+T + + H+L ++ D + +++ G+I E+GTH EL+ +G Y ++
Sbjct: 586 ECIKKTLRGKTVVLVTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKL 640
>AF411578-1|AAL99901.1| 1009|Homo sapiens ATP-binding cassette
protein C12 isoform D protein.
Length = 1009
Score = 119 bits (286), Expect = 8e-26
Identities = 74/230 (32%), Positives = 122/230 (53%), Gaps = 17/230 (7%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
VL S V+ G+ + + G+ G GKS++L L Q G V +
Sbjct: 495 VLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVA-------------VNG 541
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
+L V Q+ +F G + +NI G + + Q + +S LP G T IGERG
Sbjct: 542 TLAYVSQQAWIFHGNVRENILFGE-KYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERG 600
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVSH 589
+LSGGQ+QRI++AR++ + + LLD+ SA+D H + V + + + G+T + V+H
Sbjct: 601 LNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLVTH 660
Query: 590 RLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLV--TTGNENKEP 637
+L + + D +I ++ G I E+GTH++LM+ +G Y KL+ G + K+P
Sbjct: 661 QLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDP 710
Score = 49.2 bits (112), Expect = 9e-05
Identities = 17/55 (30%), Positives = 36/55 (65%)
Query: 1197 EALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRM 1251
E ++K +G+T + + H+L ++ D + +++ G+I E+GTH EL+ +G Y ++
Sbjct: 644 ECIKKTLRGKTVVLVTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKL 698
>AF411577-1|AAL99900.1| 1009|Homo sapiens ATP-binding cassette
protein C12 isoform C-p1 protein.
Length = 1009
Score = 119 bits (286), Expect = 8e-26
Identities = 74/230 (32%), Positives = 122/230 (53%), Gaps = 17/230 (7%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
VL S V+ G+ + + G+ G GKS++L L Q G V +
Sbjct: 495 VLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVA-------------VNG 541
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
+L V Q+ +F G + +NI G + + Q + +S LP G T IGERG
Sbjct: 542 TLAYVSQQAWIFHGNVRENILFGE-KYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERG 600
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVSH 589
+LSGGQ+QRI++AR++ + + LLD+ SA+D H + V + + + G+T + V+H
Sbjct: 601 LNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLVTH 660
Query: 590 RLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLV--TTGNENKEP 637
+L + + D +I ++ G I E+GTH++LM+ +G Y KL+ G + K+P
Sbjct: 661 QLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDP 710
Score = 49.2 bits (112), Expect = 9e-05
Identities = 17/55 (30%), Positives = 36/55 (65%)
Query: 1197 EALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRM 1251
E ++K +G+T + + H+L ++ D + +++ G+I E+GTH EL+ +G Y ++
Sbjct: 644 ECIKKTLRGKTVVLVTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKL 698
>AF395909-1|AAL79529.1| 935|Homo sapiens ATP-binding cassette
protein C12 isoform B protein.
Length = 935
Score = 119 bits (286), Expect = 8e-26
Identities = 74/230 (32%), Positives = 122/230 (53%), Gaps = 17/230 (7%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
VL S V+ G+ + + G+ G GKS++L L Q G V +
Sbjct: 495 VLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVA-------------VNG 541
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
+L V Q+ +F G + +NI G + + Q + +S LP G T IGERG
Sbjct: 542 TLAYVSQQAWIFHGNVRENILFGE-KYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERG 600
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVSH 589
+LSGGQ+QRI++AR++ + + LLD+ SA+D H + V + + + G+T + V+H
Sbjct: 601 LNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLVTH 660
Query: 590 RLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLV--TTGNENKEP 637
+L + + D +I ++ G I E+GTH++LM+ +G Y KL+ G + K+P
Sbjct: 661 QLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDP 710
Score = 49.2 bits (112), Expect = 9e-05
Identities = 17/55 (30%), Positives = 36/55 (65%)
Query: 1197 EALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRM 1251
E ++K +G+T + + H+L ++ D + +++ G+I E+GTH EL+ +G Y ++
Sbjct: 644 ECIKKTLRGKTVVLVTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKL 698
>AF395908-1|AAL79528.1| 1009|Homo sapiens ATP-binding cassette
protein C12 isoform A protein.
Length = 1009
Score = 119 bits (286), Expect = 8e-26
Identities = 74/230 (32%), Positives = 122/230 (53%), Gaps = 17/230 (7%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
VL S V+ G+ + + G+ G GKS++L L Q G V +
Sbjct: 495 VLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVA-------------VNG 541
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
+L V Q+ +F G + +NI G + + Q + +S LP G T IGERG
Sbjct: 542 TLAYVSQQAWIFHGNVRENILFGE-KYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERG 600
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVSH 589
+LSGGQ+QRI++AR++ + + LLD+ SA+D H + V + + + G+T + V+H
Sbjct: 601 LNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLVTH 660
Query: 590 RLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLV--TTGNENKEP 637
+L + + D +I ++ G I E+GTH++LM+ +G Y KL+ G + K+P
Sbjct: 661 QLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDP 710
Score = 49.2 bits (112), Expect = 9e-05
Identities = 17/55 (30%), Positives = 36/55 (65%)
Query: 1197 EALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRM 1251
E ++K +G+T + + H+L ++ D + +++ G+I E+GTH EL+ +G Y ++
Sbjct: 644 ECIKKTLRGKTVVLVTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKL 698
>AB208973-1|BAD92210.1| 776|Homo sapiens ABCC4 protein variant
protein.
Length = 776
Score = 115 bits (277), Expect = 9e-25
Identities = 73/242 (30%), Positives = 125/242 (51%), Gaps = 15/242 (6%)
Query: 396 LEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXX 455
++D + E L+G S V+PGE +A+VG G GKS++L + P G V
Sbjct: 329 VQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVS- 387
Query: 456 XXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFI 515
+ + V Q+P +F GT+ NI G E +E ++V + +
Sbjct: 388 ------------VHGRIAYVSQQPWVFSGTLRSNILFGK-EYEKERYEKVIKACALKKDL 434
Query: 516 SLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAA 574
LL +G TVIG+RG +LSGGQK R+ +AR++ ++ + LLD+ SA+D R + +
Sbjct: 435 QLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELC 494
Query: 575 LDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNEN 634
+ + + TI V+H+L + A +I+ + G +V++GT+ + +K+ + L+ NE
Sbjct: 495 ICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDNEE 554
Query: 635 KE 636
E
Sbjct: 555 SE 556
Score = 34.7 bits (76), Expect = 2.1
Identities = 23/97 (23%), Positives = 41/97 (42%), Gaps = 14/97 (14%)
Query: 1082 LKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRR 1141
L+G+ + G+ +A+VG G GKS++L P G + + R
Sbjct: 345 LQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGR------------- 391
Query: 1142 QLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAA 1178
+ V Q+P + +L NI +G K +++ A
Sbjct: 392 -IAYVSQQPWVFSGTLRSNILFGKEYEKERYEKVIKA 427
>AB209103-1|BAD92340.1| 799|Homo sapiens ATP-binding cassette C5
splicing variant A variant protein.
Length = 799
Score = 114 bits (274), Expect = 2e-24
Identities = 67/216 (31%), Positives = 112/216 (51%), Gaps = 15/216 (6%)
Query: 410 KVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLR 469
+ L + ++ G+ V + GS G GK++++ + GS+ +
Sbjct: 474 RTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIA-------------IS 520
Query: 470 SSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGER 529
+ V Q+ + T+ DNI G E E V +++LP+ T IGER
Sbjct: 521 GTFAYVAQQAWILNATLRDNILFGK-EYDEERYNSVLNSCCLRPDLAILPSSDLTEIGER 579
Query: 530 GASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVS 588
GA+LSGGQ+QRI++AR+L + ++ +LD+ SALD H + +A+ + +T + V+
Sbjct: 580 GANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVT 639
Query: 589 HRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFY 624
H+L +V+ D +I M +G I E+GTHE+LM G Y
Sbjct: 640 HQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDY 675
Score = 45.6 bits (103), Expect = 0.001
Identities = 19/51 (37%), Positives = 31/51 (60%)
Query: 1198 ALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHY 1248
A+ K K +T + + H+L + D D + + +G I ERGTH EL+++ G Y
Sbjct: 625 AIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDY 675
Score = 33.9 bits (74), Expect = 3.7
Identities = 13/31 (41%), Positives = 22/31 (70%)
Query: 1079 QRVLKGIDLKMEAGKTIALVGSSGCGKSTIL 1109
QR L IDL+++ GK + + GS G GK++++
Sbjct: 473 QRTLHSIDLEIQEGKLVGICGSVGSGKTSLI 503
>BC041560-1|AAH41560.1| 859|Homo sapiens ABCC4 protein protein.
Length = 859
Score = 113 bits (273), Expect = 3e-24
Identities = 72/242 (29%), Positives = 125/242 (51%), Gaps = 15/242 (6%)
Query: 396 LEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXX 455
++D + E L+G S V+PGE +A+VG G GKS++L + P G V
Sbjct: 412 VQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVS- 470
Query: 456 XXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFI 515
+ + V Q+P +F GT+ NI G + +E ++V + +
Sbjct: 471 ------------VHGRIAYVSQQPWVFSGTLRSNILFGK-KYEKERYEKVIKACALKKDL 517
Query: 516 SLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAA 574
LL +G TVIG+RG +LSGGQK R+ +AR++ ++ + LLD+ SA+D R + +
Sbjct: 518 QLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELC 577
Query: 575 LDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNEN 634
+ + + TI V+H+L + A +I+ + G +V++GT+ + +K+ + L+ NE
Sbjct: 578 ICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDNEE 637
Query: 635 KE 636
E
Sbjct: 638 SE 639
Score = 34.7 bits (76), Expect = 2.1
Identities = 23/97 (23%), Positives = 41/97 (42%), Gaps = 14/97 (14%)
Query: 1082 LKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRR 1141
L+G+ + G+ +A+VG G GKS++L P G + + R
Sbjct: 428 LQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGR------------- 474
Query: 1142 QLGVVQQEPVLLDRSLAENIAYGDNNRKVTMHEIVAA 1178
+ V Q+P + +L NI +G K +++ A
Sbjct: 475 -IAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKA 510
>L09191-1|AAA58648.1| 129|Homo sapiens TAP2 protein.
Length = 129
Score = 113 bits (272), Expect = 4e-24
Identities = 57/127 (44%), Positives = 79/127 (62%)
Query: 443 QRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEI 502
Q LY P G V +L S + VGQEPVLF G++ +NIA G +++
Sbjct: 1 QNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKV 60
Query: 503 QRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSA 562
A+ A+A DFI + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDEATSA
Sbjct: 61 MAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSA 120
Query: 563 LDPHSER 569
LD E+
Sbjct: 121 LDVQCEQ 127
Score = 43.2 bits (97), Expect = 0.006
Identities = 32/93 (34%), Positives = 47/93 (50%), Gaps = 4/93 (4%)
Query: 1113 QRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTM 1172
Q Y P G + LD + I S L Q+ V QEPVL S+ NIAYG +
Sbjct: 1 QNLYQPTGGQVLLDEKPI-SQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYG--LQSCED 57
Query: 1173 HEIVAAAKAANIHSFIVSLPKAV-TEALEKAAK 1204
+++AAA+AA+ FI + + T+ EK ++
Sbjct: 58 DKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQ 90
>L10287-1|AAA58649.1| 129|Homo sapiens TAP2 protein.
Length = 129
Score = 111 bits (268), Expect = 1e-23
Identities = 56/127 (44%), Positives = 78/127 (61%)
Query: 443 QRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEI 502
Q LY P G V +L S + VGQEPVLF G++ +NI G +++
Sbjct: 1 QNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNITYGLQSCEDDKV 60
Query: 503 QRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSA 562
A+ A+A DFI + +G T +GE+G+ L+ GQKQR+AIAR+L+R+P VL+LDEATSA
Sbjct: 61 MAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSA 120
Query: 563 LDPHSER 569
LD E+
Sbjct: 121 LDVQCEQ 127
Score = 41.5 bits (93), Expect = 0.018
Identities = 31/93 (33%), Positives = 46/93 (49%), Gaps = 4/93 (4%)
Query: 1113 QRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTM 1172
Q Y P G + LD + I S L Q+ V QEPVL S+ NI YG +
Sbjct: 1 QNLYQPTGGQVLLDEKPI-SQYEHCYLHSQVVSVGQEPVLFSGSVRNNITYG--LQSCED 57
Query: 1173 HEIVAAAKAANIHSFIVSLPKAV-TEALEKAAK 1204
+++AAA+AA+ FI + + T+ EK ++
Sbjct: 58 DKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQ 90
>AF411579-1|AAL99902.1| 1344|Homo sapiens ATP-binding cassette
protein C11 isoform A protein.
Length = 1344
Score = 107 bits (257), Expect = 2e-22
Identities = 70/218 (32%), Positives = 115/218 (52%), Gaps = 15/218 (6%)
Query: 412 LKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSS 471
L ++ V G + + G++G GKS++L + GSV ++ S
Sbjct: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVG-------------VQGS 573
Query: 472 LGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGA 531
L V Q+ + G I +NI +G +Q + + D + LLP G T IGERG
Sbjct: 574 LAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRD-LELLPFGDMTEIGERGL 632
Query: 532 SLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVSHR 590
+LSGGQKQRI++AR++ + + LLD+ SA+D H + + + + + G+T + V+H+
Sbjct: 633 NLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQ 692
Query: 591 LSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLV 628
L + +II ++ G I E GTH +LM+ KG Y +L+
Sbjct: 693 LQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI 730
Score = 81.8 bits (193), Expect = 1e-14
Identities = 100/457 (21%), Positives = 194/457 (42%), Gaps = 33/457 (7%)
Query: 796 ISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQG 855
+ +C S FT K +T L ++ F + + + FFD T +G + +GD ++
Sbjct: 876 VGVC-SSGIFTKVTRKASTALHNKLFNKVFRCPMSFFD--TIPIGRLLNCFAGDLEQLDQ 932
Query: 856 ATGLRIGLILQGISSVVVGFLLAISY--NWKLTLVATVFLPLMVGSIWLEGIISQKAQID 913
+ L +S +V+ LL +S + L + A + + + + + I +++
Sbjct: 933 LLPIFSEQFLV-LSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLE 991
Query: 914 ERNAMESATAIATEAVVSIKTVQSLGVETVFLQKFQ---DALKTACVAVAYKTRWRGLVY 970
+ + I ++ + ++ G F+ +F+ DA + TRW L
Sbjct: 992 NYSRSPLFSHILN-SLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRL 1050
Query: 971 GLGVYIPFMAYCSATVYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLV--YAPSLNT 1028
+ + +A +G Y +K V+ VN + + + + + T
Sbjct: 1051 EIMTNLVTLAVALFVAFGISSTPYS---FK-VMAVNIVLQLASSFQATARIGLETEAQFT 1106
Query: 1029 AKACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLK 1088
A + + + + +H G + W G +D Y + VL GI+L
Sbjct: 1107 AVERILQYMKMCVSEAPLHME-GTSCPQGWPQHGEIIFQDYHMKYRDN-TPTVLHGINLT 1164
Query: 1089 MEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQ 1148
+ + + +VG +G GKS++ R +P +G I +D DI S + + LR +L V+ Q
Sbjct: 1165 IRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICS-IGLEDLRSKLSVIPQ 1223
Query: 1149 EPVLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKA-----------VTE 1197
+PVLL ++ N+ D + T +I A + + I+ + +A +
Sbjct: 1224 DPVLLSGTIRFNLDPFDRH---TDQQIWDALERTFLTKAIILIDEATASIDMETDTLIQR 1280
Query: 1198 ALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVE 1234
+ +A +G T + IAHR++TV + D I V+ GK+VE
Sbjct: 1281 TIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVE 1317
Score = 59.3 bits (137), Expect = 9e-08
Identities = 34/99 (34%), Positives = 50/99 (50%), Gaps = 1/99 (1%)
Query: 392 GDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAG 451
G+I+ +D Y VL G ++ ++ E V +VG +G GKS++ L RL +P AG
Sbjct: 1139 GEIIFQDYHMKYRDNTPT-VLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAG 1197
Query: 452 SVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNI 490
+ LRS L V+ Q+PVL GTI N+
Sbjct: 1198 RILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNL 1236
Score = 58.8 bits (136), Expect = 1e-07
Identities = 28/81 (34%), Positives = 50/81 (61%), Gaps = 1/81 (1%)
Query: 542 AIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRII 601
A+ R+ L + A++L+DEAT+++D ++ +Q + A G T + ++HR++T++N D I+
Sbjct: 1250 ALERTFLTK-AIILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHIL 1308
Query: 602 CMDQGVIVEQGTHEDLMKAKG 622
M G +VE E L K G
Sbjct: 1309 VMGNGKVVEFDRPEVLRKKPG 1329
Score = 48.8 bits (111), Expect = 1e-04
Identities = 19/52 (36%), Positives = 33/52 (63%)
Query: 1197 EALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHY 1248
E ++K +G+T + + H+L ++ I +++ GKI E GTH+EL+ KG Y
Sbjct: 675 ECIKKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKY 726
>AB209084-1|BAD92321.1| 1011|Homo sapiens Sulfonylurea receptor 1
variant protein.
Length = 1011
Score = 106 bits (255), Expect = 4e-22
Identities = 73/229 (31%), Positives = 113/229 (49%), Gaps = 17/229 (7%)
Query: 409 VKVLKGFSIHVKPGECVALVGSSGCGKSTVLQL----LQR---------LYDPQAGSVXX 455
+ L +I + G+ +VG GCGKS++L +Q+ L D + G
Sbjct: 697 IPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPS 756
Query: 456 XXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFI 515
R + Q+P L T+ +NI SP ++ + V E I
Sbjct: 757 PERETATDLDIRKRGPVAYASQKPWLLNATVEENIIFESP-FNKQRYKMVIEACSLQPDI 815
Query: 516 SLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPH-SERQVQAA 574
+LP+G T IGERG +LSGGQ+QRI++AR+L + V+ LD+ SALD H S+ +QA
Sbjct: 816 DILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLMQAG 875
Query: 575 LDR--ASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAK 621
+ RT + V+H+L + +AD II M G I +GT +D +++
Sbjct: 876 ILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSE 924
>AC003026-1|AAC05808.1| 691|Homo sapiens Multiple drug resistance
gene MRP1 (partial) protein.
Length = 691
Score = 103 bits (248), Expect = 3e-21
Identities = 74/273 (27%), Positives = 132/273 (48%), Gaps = 20/273 (7%)
Query: 372 EREPKIDSLQQKGLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSS 431
E EP DS++++ + I + + F + +R + L G + + G VA+VG
Sbjct: 109 ELEP--DSIERRPVKDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQV 165
Query: 432 GCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIA 491
GCGKS++L L D G V ++ S+ V Q+ + ++ +NI
Sbjct: 166 GCGKSSLLSALLAEMDKVEGHVA-------------IKGSVAYVPQQAWIQNDSLRENIL 212
Query: 492 IGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREP 551
G + + V + + +LP+G T IGE+G +LSGGQKQR+++AR++
Sbjct: 213 FGC-QLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNA 271
Query: 552 AVLLLDEATSALDPHSERQV-QAALDRASV--GRTTITVSHRLSTIVNADRIICMDQGVI 608
+ L D+ SA+D H + + + + + +T I V+H +S + D II M G I
Sbjct: 272 DIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKI 331
Query: 609 VEQGTHEDLMKAKGFYHKLVTTGNENKEPADIE 641
E G++++L+ G + + + T ++ D E
Sbjct: 332 SEMGSYQELLARDGAFAEFLRTYASTEQEQDAE 364
Score = 37.9 bits (84), Expect = 0.23
Identities = 20/70 (28%), Positives = 33/70 (47%), Gaps = 1/70 (1%)
Query: 1056 KDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRF 1115
KD + + ++R+ F + R L GI + G +A+VG GCGKS++L
Sbjct: 121 KDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAE 179
Query: 1116 YDPDSGFIEL 1125
D G + +
Sbjct: 180 MDKVEGHVAI 189
Score = 36.7 bits (81), Expect = 0.53
Identities = 17/50 (34%), Positives = 28/50 (56%)
Query: 1204 KGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHYWRMCR 1253
K +T I + H +S + D+I V+ GKI E G++ EL++ G + R
Sbjct: 303 KNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLR 352
>X57521-1|CAA40740.1| 430|Homo sapiens Y3 protein.
Length = 430
Score = 103 bits (247), Expect = 4e-21
Identities = 76/300 (25%), Positives = 144/300 (48%), Gaps = 18/300 (6%)
Query: 148 SVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPLGW- 206
+VLRQ+ ++ + N+ S+++E+ ++ + + E L++ + V LC + W
Sbjct: 145 AVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSL---FLWYLVRGLCLLGIMLWG 201
Query: 207 --QLTLACAAVMPFSVITSIALSNYQTKSSIREMESYSLAGKQAEEILKSVRTIVAFGGE 264
LT+ +P + + + ++ ES + + + A E L ++ T+ +F E
Sbjct: 202 SVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANE 261
Query: 265 NKEVERYRRLLEPAEEFGRKRGLFTGLGNGFNWVLTYSLNAIGFSY-GTRLVVNDFDTDS 323
E +++R L+ + +K + + N + ++ L +G Y G +LV + +
Sbjct: 262 EGEAQKFREKLQEIKTLNQKEAVAYAV-NSWTTSISGMLLKVGILYIGGQLVTSGAVSSG 320
Query: 324 NLRQYPVGAVYSILFSVYMATQSITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQK 383
NL + +Y + F+ A + + P ++ IF ++R P+
Sbjct: 321 NLVTF---VLYQMQFT--QAVEVLLSIYPRVQ---KAVGSSEKIFEYLDRTPRCPPSGL- 371
Query: 384 GLTPRRVVGDILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQ 443
LTP + G + +DV F YP+RP+V VL+G + ++PGE ALVG +G GKSTV LLQ
Sbjct: 372 -LTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQ 430
Score = 82.6 bits (195), Expect = 8e-15
Identities = 80/308 (25%), Positives = 141/308 (45%), Gaps = 21/308 (6%)
Query: 814 TRLRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGI--SSV 871
+ L+ + F ++L+QE FF + N G I +R++ DT+ + + + L L +
Sbjct: 136 SHLQGEVFGAVLRQETEFFQQ--NQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLC 193
Query: 872 VVGFLLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVS 931
++G +L S + LT+V + LPL+ G Q ++ R ++ ++ +A EA+ +
Sbjct: 194 LLGIMLWGSVS--LTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSA 251
Query: 932 IKTVQSLGVETVFLQKFQDALKTACV-----AVAYKTR-WRGLVYGLGVYIPFMAYCSAT 985
+ TV+S E QKF++ L+ AVAY W + G+ + + + Y
Sbjct: 252 MPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGIL-YIGGQ 310
Query: 986 VYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYAPSLNTAKACGARILSIIQRQPK 1045
+ + V+ G LV V + + + +Y P + A +I + R P+
Sbjct: 311 LVTSGAVSSGN----LVTFVLYQMQFTQAVEVLLSIY-PRVQKAVGSSEKIFEYLDRTPR 365
Query: 1046 IHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGK 1105
+ G+ G +DV F YP RP VL+G+ + G+ ALVG +G GK
Sbjct: 366 CPPS-GLLTPLH--LEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGK 422
Query: 1106 STILQLFQ 1113
ST+ L Q
Sbjct: 423 STVAALLQ 430
>U91318-3|AAC15785.1| 848|Homo sapiens Gene product with similarity
to Multidrug resistance protein MRP1 protein.
Length = 848
Score = 101 bits (243), Expect = 1e-20
Identities = 123/537 (22%), Positives = 220/537 (40%), Gaps = 34/537 (6%)
Query: 108 MAIGMFISIGVSLVFCVLSFSLISWSALRQITRIRTLFLRSVLRQDMSWYDTDSEFNLAS 167
+A+ MF+S + +F + + +R + I L R VL + ++ +
Sbjct: 310 LAVLMFLSACLQTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVN 369
Query: 168 KMSENLMSIKEGMGEKLAVVSNLVGTSVICLCTAFPLGWQLTLACAAVMPFSVITSIALS 227
+S ++ + E + + LV V+C + L L AV + + +S
Sbjct: 370 LVSVDVQRLTESVLYLNGLWLPLVWI-VVCFVYLWQLLGPSALTAIAVFLSLLPLNFFIS 428
Query: 228 NYQTKSSIREMESYSLAGKQAEEILKSVRTIVAFGGENKEVERYRRLLEPAEEFG--RKR 285
+ +M + IL++ +TI G E ++R + +E G R
Sbjct: 429 KKRNHHQEEQMRQKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIR--GQELGALRTS 486
Query: 286 GLFTGLGNGFNWVLTYSLNAIGFSYGTRLVVNDFDTDSNLRQYPVGAVYSILFSVYMATQ 345
GL + V T+ + + F+ T + N + + ++L + A
Sbjct: 487 GLLFSVSLVSFQVSTFLVALVVFAVHTLVAENAMNAEKAF------VTLTVLNILNKAQA 540
Query: 346 SITFCVPHLEGFXXXXXXXXSIFHLIEREPKIDSLQQKGLTPRRVVGDILLEDVEFCYPS 405
+ F + L + L E +P + G + I + F + S
Sbjct: 541 FLPFSIHSLVQARVSFDRLVTFLCLEEVDPGVVDSSSSGSAAGKDC--ITIHSATFAW-S 597
Query: 406 RPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXX 465
+ L ++ V G +A+VG G GKS++L L G V
Sbjct: 598 QESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVS----------- 646
Query: 466 SWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTV 525
+ ++ V QE + ++ +N+ G E ++RV E + P G T
Sbjct: 647 --IEGAVAYVPQEAWVQNTSVVENVCFGQ-ELDPPWLERVLEACALQPDVDSFPEGIHTS 703
Query: 526 IGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASV--GR 582
IGE+G +LSGGQKQR+++AR++ R+ AV LLD+ +ALD H + V + + G
Sbjct: 704 IGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGT 763
Query: 583 TTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENKEPAD 639
T I V+H L + AD II + G I E G++++L++ KG LV ++ ++P D
Sbjct: 764 TRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKG---ALVCLLDQARQPGD 817
>M55131-1|AAC13657.1| 1480|Homo sapiens cystic fibrosis transmembrane
conductance regulator protein.
Length = 1480
Score = 100 bits (239), Expect = 4e-20
Identities = 58/225 (25%), Positives = 110/225 (48%), Gaps = 2/225 (0%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
+L+ S + PG+ V L+G +G GKST+L RL + + W R
Sbjct: 1226 ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQW-RK 1284
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
+ GV+ Q+ +F GT N+ + + +EI +VA+ I P D V+ + G
Sbjct: 1285 AFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGG 1343
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHR 590
LS G KQ + +ARS+L + +LLLDE ++ LDP + + ++ L +A T I HR
Sbjct: 1344 CVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHR 1403
Query: 591 LSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENK 635
+ ++ + + +++ + + + + L+ + + + ++ + K
Sbjct: 1404 IEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVK 1448
Score = 82.2 bits (194), Expect = 1e-14
Identities = 56/220 (25%), Positives = 106/220 (48%), Gaps = 16/220 (7%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
VLK + ++ G+ +A+ GS+G GK+++L ++ +P G + SW+
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGRISFCSQFSWIMP 499
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
GTI +NI G + V + + IS + V+GE G
Sbjct: 500 -------------GTIKENIIFGV-SYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGG 545
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVSH 589
+LSGGQ+ RI++AR++ ++ + LLD LD +E+++ ++ + + +T I V+
Sbjct: 546 ITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTS 605
Query: 590 RLSTIVNADRIICMDQGVIVEQGTHEDLMKAK-GFYHKLV 628
++ + AD+I+ + +G GT +L + F KL+
Sbjct: 606 KMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 65.3 bits (152), Expect = 1e-09
Identities = 96/397 (24%), Positives = 166/397 (41%), Gaps = 32/397 (8%)
Query: 816 LRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGF 875
L H+ S+L+ + + T G I R S D A + L I +Q + +V+G
Sbjct: 948 LHHKMLHSVLQAPMSTLN--TLKAGGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGA 1004
Query: 876 LLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIK-- 933
+ ++ VATV P++V I L Q +Q ++ E + I T V S+K
Sbjct: 1005 IAVVAVLQPYIFVATV--PVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGL 1062
Query: 934 -TVQSLGVETVFLQKFQDALK--TACVAVAYKT-RWRGLVYGLGVYIPFMAYCSATVY-- 987
T+++ G + F F AL TA + T RW + + I F+A ++
Sbjct: 1063 WTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTT 1122
Query: 988 -------GAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYA----PSLNT-AKACGAR 1035
G +L + L VN +I + M S V+ P+ K+
Sbjct: 1123 GEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPY 1182
Query: 1036 ILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTI 1095
+ + I N+ VK W + G +++D+ Y T +L+ I + G+ +
Sbjct: 1183 KNGQLSKVMIIENS-HVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRV 1240
Query: 1096 ALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDR 1155
L+G +G GKST+L F R + + G I++D S +T+ + R+ GV+ Q+ +
Sbjct: 1241 GLLGRTGSGKSTLLSAFLRLLNTE-GEIQIDGVSWDS-ITLQQWRKAFGVIPQKVFIFSG 1298
Query: 1156 SLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP 1192
+ +N+ D + + EI A + S I P
Sbjct: 1299 TFRKNL---DPYEQWSDQEIWKVADEVGLRSVIEQFP 1332
Score = 40.7 bits (91), Expect = 0.032
Identities = 18/48 (37%), Positives = 30/48 (62%)
Query: 1081 VLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNR 1128
VLK I+ K+E G+ +A+ GS+G GK+++L + +P G I+ R
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGR 487
>M28668-1|AAA35680.1| 1480|Homo sapiens protein ( Human cystic
fibrosis mRNA, encoding a presumed transmembrane
conductance regulator (CFTR). ).
Length = 1480
Score = 100 bits (239), Expect = 4e-20
Identities = 58/225 (25%), Positives = 110/225 (48%), Gaps = 2/225 (0%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
+L+ S + PG+ V L+G +G GKST+L RL + + W R
Sbjct: 1226 ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQW-RK 1284
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
+ GV+ Q+ +F GT N+ + + +EI +VA+ I P D V+ + G
Sbjct: 1285 AFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGG 1343
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHR 590
LS G KQ + +ARS+L + +LLLDE ++ LDP + + ++ L +A T I HR
Sbjct: 1344 CVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHR 1403
Query: 591 LSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENK 635
+ ++ + + +++ + + + + L+ + + + ++ + K
Sbjct: 1404 IEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVK 1448
Score = 83.0 bits (196), Expect = 6e-15
Identities = 56/220 (25%), Positives = 107/220 (48%), Gaps = 16/220 (7%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
VLK + ++ G+ +A+ GS+G GK+++L ++ +P G + SW+
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGRISFCSQFSWIMP 499
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
GTI +NI G + V + + IS + V+GE G
Sbjct: 500 -------------GTIKENIIFGV-SYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGG 545
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVSH 589
+LSGGQ+ RI++AR++ ++ + LLD LD +E+++ ++ + + +T I V+
Sbjct: 546 ITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTS 605
Query: 590 RLSTIVNADRIICMDQGVIVEQGTHEDLMKAK-GFYHKLV 628
++ + AD+I+ +++G GT +L + F KL+
Sbjct: 606 KMEHLKKADKILILNEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 65.3 bits (152), Expect = 1e-09
Identities = 96/397 (24%), Positives = 166/397 (41%), Gaps = 32/397 (8%)
Query: 816 LRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGF 875
L H+ S+L+ + + T G I R S D A + L I +Q + +V+G
Sbjct: 948 LHHKMLHSVLQAPMSTLN--TLKAGGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGA 1004
Query: 876 LLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIK-- 933
+ ++ VATV P++V I L Q +Q ++ E + I T V S+K
Sbjct: 1005 IAVVAVLQPYIFVATV--PVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGL 1062
Query: 934 -TVQSLGVETVFLQKFQDALK--TACVAVAYKT-RWRGLVYGLGVYIPFMAYCSATVY-- 987
T+++ G + F F AL TA + T RW + + I F+A ++
Sbjct: 1063 WTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTT 1122
Query: 988 -------GAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYA----PSLNT-AKACGAR 1035
G +L + L VN +I + M S V+ P+ K+
Sbjct: 1123 GEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPY 1182
Query: 1036 ILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTI 1095
+ + I N+ VK W + G +++D+ Y T +L+ I + G+ +
Sbjct: 1183 KNGQLSKVMIIENS-HVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRV 1240
Query: 1096 ALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDR 1155
L+G +G GKST+L F R + + G I++D S +T+ + R+ GV+ Q+ +
Sbjct: 1241 GLLGRTGSGKSTLLSAFLRLLNTE-GEIQIDGVSWDS-ITLQQWRKAFGVIPQKVFIFSG 1298
Query: 1156 SLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP 1192
+ +N+ D + + EI A + S I P
Sbjct: 1299 TFRKNL---DPYEQWSDQEIWKVADEVGLRSVIEQFP 1332
Score = 40.7 bits (91), Expect = 0.032
Identities = 18/48 (37%), Positives = 30/48 (62%)
Query: 1081 VLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNR 1128
VLK I+ K+E G+ +A+ GS+G GK+++L + +P G I+ R
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGR 487
>DQ388145-1|ABD72217.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 100 bits (239), Expect = 4e-20
Identities = 58/225 (25%), Positives = 110/225 (48%), Gaps = 2/225 (0%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
+L+ S + PG+ V L+G +G GKST+L RL + + W R
Sbjct: 1226 ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQW-RK 1284
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
+ GV+ Q+ +F GT N+ + + +EI +VA+ I P D V+ + G
Sbjct: 1285 AFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGG 1343
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHR 590
LS G KQ + +ARS+L + +LLLDE ++ LDP + + ++ L +A T I HR
Sbjct: 1344 CVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHR 1403
Query: 591 LSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENK 635
+ ++ + + +++ + + + + L+ + + + ++ + K
Sbjct: 1404 IEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVK 1448
Score = 81.8 bits (193), Expect = 1e-14
Identities = 56/220 (25%), Positives = 106/220 (48%), Gaps = 16/220 (7%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
VLK + ++ G+ +A+ GS+G GK+++L ++ +P G + SW+
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIMP 499
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
GTI +NI G + V + + IS + V+GE G
Sbjct: 500 -------------GTIKENIIFGV-SYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGG 545
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVSH 589
+LSGGQ+ RI++AR++ ++ + LLD LD +E+++ ++ + + +T I V+
Sbjct: 546 ITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTS 605
Query: 590 RLSTIVNADRIICMDQGVIVEQGTHEDLMKAK-GFYHKLV 628
++ + AD+I+ + +G GT +L + F KL+
Sbjct: 606 KMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 65.3 bits (152), Expect = 1e-09
Identities = 96/397 (24%), Positives = 166/397 (41%), Gaps = 32/397 (8%)
Query: 816 LRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGF 875
L H+ S+L+ + + T G I R S D A + L I +Q + +V+G
Sbjct: 948 LHHKMLHSVLQAPMSTLN--TLKAGGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGA 1004
Query: 876 LLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIK-- 933
+ ++ VATV P++V I L Q +Q ++ E + I T V S+K
Sbjct: 1005 IAVVAVLQPYIFVATV--PVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGL 1062
Query: 934 -TVQSLGVETVFLQKFQDALK--TACVAVAYKT-RWRGLVYGLGVYIPFMAYCSATVY-- 987
T+++ G + F F AL TA + T RW + + I F+A ++
Sbjct: 1063 WTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTT 1122
Query: 988 -------GAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYA----PSLNT-AKACGAR 1035
G +L + L VN +I + M S V+ P+ K+
Sbjct: 1123 GEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPY 1182
Query: 1036 ILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTI 1095
+ + I N+ VK W + G +++D+ Y T +L+ I + G+ +
Sbjct: 1183 KNGQLSKVMIIENS-HVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRV 1240
Query: 1096 ALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDR 1155
L+G +G GKST+L F R + + G I++D S +T+ + R+ GV+ Q+ +
Sbjct: 1241 GLLGRTGSGKSTLLSAFLRLLNTE-GEIQIDGVSWDS-ITLQQWRKAFGVIPQKVFIFSG 1298
Query: 1156 SLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP 1192
+ +N+ D + + EI A + S I P
Sbjct: 1299 TFRKNL---DPYEQWSDQEIWKVADEVGLRSVIEQFP 1332
Score = 40.3 bits (90), Expect = 0.043
Identities = 18/48 (37%), Positives = 30/48 (62%)
Query: 1081 VLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNR 1128
VLK I+ K+E G+ +A+ GS+G GK+++L + +P G I+ R
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGR 487
>DQ388143-1|ABD72213.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 100 bits (239), Expect = 4e-20
Identities = 58/225 (25%), Positives = 110/225 (48%), Gaps = 2/225 (0%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
+L+ S + PG+ V L+G +G GKST+L RL + + W R
Sbjct: 1226 ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQW-RK 1284
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
+ GV+ Q+ +F GT N+ + + +EI +VA+ I P D V+ + G
Sbjct: 1285 AFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGG 1343
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHR 590
LS G KQ + +ARS+L + +LLLDE ++ LDP + + ++ L +A T I HR
Sbjct: 1344 CVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHR 1403
Query: 591 LSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENK 635
+ ++ + + +++ + + + + L+ + + + ++ + K
Sbjct: 1404 IEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVK 1448
Score = 81.8 bits (193), Expect = 1e-14
Identities = 56/220 (25%), Positives = 106/220 (48%), Gaps = 16/220 (7%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
VLK + ++ G+ +A+ GS+G GK+++L ++ +P G + SW+
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIMP 499
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
GTI +NI G + V + + IS + V+GE G
Sbjct: 500 -------------GTIKENIIFGV-SYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGG 545
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVSH 589
+LSGGQ+ RI++AR++ ++ + LLD LD +E+++ ++ + + +T I V+
Sbjct: 546 ITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTS 605
Query: 590 RLSTIVNADRIICMDQGVIVEQGTHEDLMKAK-GFYHKLV 628
++ + AD+I+ + +G GT +L + F KL+
Sbjct: 606 KMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 65.3 bits (152), Expect = 1e-09
Identities = 96/397 (24%), Positives = 166/397 (41%), Gaps = 32/397 (8%)
Query: 816 LRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGF 875
L H+ S+L+ + + T G I R S D A + L I +Q + +V+G
Sbjct: 948 LHHKMLHSVLQAPMSTLN--TLKAGGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGA 1004
Query: 876 LLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIK-- 933
+ ++ VATV P++V I L Q +Q ++ E + I T V S+K
Sbjct: 1005 IAVVAVLQPYIFVATV--PVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGL 1062
Query: 934 -TVQSLGVETVFLQKFQDALK--TACVAVAYKT-RWRGLVYGLGVYIPFMAYCSATVY-- 987
T+++ G + F F AL TA + T RW + + I F+A ++
Sbjct: 1063 WTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTT 1122
Query: 988 -------GAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYA----PSLNT-AKACGAR 1035
G +L + L VN +I + M S V+ P+ K+
Sbjct: 1123 GEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPY 1182
Query: 1036 ILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTI 1095
+ + I N+ VK W + G +++D+ Y T +L+ I + G+ +
Sbjct: 1183 KNGQLSKVMIIENS-HVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRV 1240
Query: 1096 ALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDR 1155
L+G +G GKST+L F R + + G I++D S +T+ + R+ GV+ Q+ +
Sbjct: 1241 GLLGRTGSGKSTLLSAFLRLLNTE-GEIQIDGVSWDS-ITLQQWRKAFGVIPQKVFIFSG 1298
Query: 1156 SLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP 1192
+ +N+ D + + EI A + S I P
Sbjct: 1299 TFRKNL---DPYEQWSDQEIWKVADEVGLRSVIEQFP 1332
Score = 40.3 bits (90), Expect = 0.043
Identities = 18/48 (37%), Positives = 30/48 (62%)
Query: 1081 VLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNR 1128
VLK I+ K+E G+ +A+ GS+G GK+++L + +P G I+ R
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGR 487
>DQ388142-1|ABD72211.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 100 bits (239), Expect = 4e-20
Identities = 58/225 (25%), Positives = 110/225 (48%), Gaps = 2/225 (0%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
+L+ S + PG+ V L+G +G GKST+L RL + + W R
Sbjct: 1226 ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQW-RK 1284
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
+ GV+ Q+ +F GT N+ + + +EI +VA+ I P D V+ + G
Sbjct: 1285 AFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGG 1343
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHR 590
LS G KQ + +ARS+L + +LLLDE ++ LDP + + ++ L +A T I HR
Sbjct: 1344 CVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHR 1403
Query: 591 LSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENK 635
+ ++ + + +++ + + + + L+ + + + ++ + K
Sbjct: 1404 IEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVK 1448
Score = 81.8 bits (193), Expect = 1e-14
Identities = 56/220 (25%), Positives = 106/220 (48%), Gaps = 16/220 (7%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
VLK + ++ G+ +A+ GS+G GK+++L ++ +P G + SW+
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIMP 499
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
GTI +NI G + V + + IS + V+GE G
Sbjct: 500 -------------GTIKENIIFGV-SYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGG 545
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVSH 589
+LSGGQ+ RI++AR++ ++ + LLD LD +E+++ ++ + + +T I V+
Sbjct: 546 ITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTS 605
Query: 590 RLSTIVNADRIICMDQGVIVEQGTHEDLMKAK-GFYHKLV 628
++ + AD+I+ + +G GT +L + F KL+
Sbjct: 606 KMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 65.3 bits (152), Expect = 1e-09
Identities = 96/397 (24%), Positives = 166/397 (41%), Gaps = 32/397 (8%)
Query: 816 LRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGF 875
L H+ S+L+ + + T G I R S D A + L I +Q + +V+G
Sbjct: 948 LHHKMLHSVLQAPMSTLN--TLKAGGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGA 1004
Query: 876 LLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIK-- 933
+ ++ VATV P++V I L Q +Q ++ E + I T V S+K
Sbjct: 1005 IAVVAVLQPYIFVATV--PVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGL 1062
Query: 934 -TVQSLGVETVFLQKFQDALK--TACVAVAYKT-RWRGLVYGLGVYIPFMAYCSATVY-- 987
T+++ G + F F AL TA + T RW + + I F+A ++
Sbjct: 1063 WTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTT 1122
Query: 988 -------GAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYA----PSLNT-AKACGAR 1035
G +L + L VN +I + M S V+ P+ K+
Sbjct: 1123 GEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPY 1182
Query: 1036 ILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTI 1095
+ + I N+ VK W + G +++D+ Y T +L+ I + G+ +
Sbjct: 1183 KNGQLSKVMIIENS-HVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRV 1240
Query: 1096 ALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDR 1155
L+G +G GKST+L F R + + G I++D S +T+ + R+ GV+ Q+ +
Sbjct: 1241 GLLGRTGSGKSTLLSAFLRLLNTE-GEIQIDGVSWDS-ITLQQWRKAFGVIPQKVFIFSG 1298
Query: 1156 SLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP 1192
+ +N+ D + + EI A + S I P
Sbjct: 1299 TFRKNL---DPYEQWSDQEIWKVADEVGLRSVIEQFP 1332
Score = 40.3 bits (90), Expect = 0.043
Identities = 18/48 (37%), Positives = 30/48 (62%)
Query: 1081 VLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNR 1128
VLK I+ K+E G+ +A+ GS+G GK+++L + +P G I+ R
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGR 487
>DQ388141-1|ABD72209.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 100 bits (239), Expect = 4e-20
Identities = 58/225 (25%), Positives = 110/225 (48%), Gaps = 2/225 (0%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
+L+ S + PG+ V L+G +G GKST+L RL + + W R
Sbjct: 1226 ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQW-RK 1284
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
+ GV+ Q+ +F GT N+ + + +EI +VA+ I P D V+ + G
Sbjct: 1285 AFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGG 1343
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHR 590
LS G KQ + +ARS+L + +LLLDE ++ LDP + + ++ L +A T I HR
Sbjct: 1344 CVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHR 1403
Query: 591 LSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENK 635
+ ++ + + +++ + + + + L+ + + + ++ + K
Sbjct: 1404 IEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVK 1448
Score = 81.8 bits (193), Expect = 1e-14
Identities = 56/220 (25%), Positives = 106/220 (48%), Gaps = 16/220 (7%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
VLK + ++ G+ +A+ GS+G GK+++L ++ +P G + SW+
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIMP 499
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
GTI +NI G + V + + IS + V+GE G
Sbjct: 500 -------------GTIKENIIFGV-SYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGG 545
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVSH 589
+LSGGQ+ RI++AR++ ++ + LLD LD +E+++ ++ + + +T I V+
Sbjct: 546 ITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTS 605
Query: 590 RLSTIVNADRIICMDQGVIVEQGTHEDLMKAK-GFYHKLV 628
++ + AD+I+ + +G GT +L + F KL+
Sbjct: 606 KMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 65.3 bits (152), Expect = 1e-09
Identities = 96/397 (24%), Positives = 166/397 (41%), Gaps = 32/397 (8%)
Query: 816 LRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGF 875
L H+ S+L+ + + T G I R S D A + L I +Q + +V+G
Sbjct: 948 LHHKMLHSVLQAPMSTLN--TLKAGGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGA 1004
Query: 876 LLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIK-- 933
+ ++ VATV P++V I L Q +Q ++ E + I T V S+K
Sbjct: 1005 IAVVAVLQPYIFVATV--PVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGL 1062
Query: 934 -TVQSLGVETVFLQKFQDALK--TACVAVAYKT-RWRGLVYGLGVYIPFMAYCSATVY-- 987
T+++ G + F F AL TA + T RW + + I F+A ++
Sbjct: 1063 WTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTT 1122
Query: 988 -------GAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYA----PSLNT-AKACGAR 1035
G +L + L VN +I + M S V+ P+ K+
Sbjct: 1123 GEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPY 1182
Query: 1036 ILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTI 1095
+ + I N+ VK W + G +++D+ Y T +L+ I + G+ +
Sbjct: 1183 KNGQLSKVMIIENS-HVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRV 1240
Query: 1096 ALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDR 1155
L+G +G GKST+L F R + + G I++D S +T+ + R+ GV+ Q+ +
Sbjct: 1241 GLLGRTGSGKSTLLSAFLRLLNTE-GEIQIDGVSWDS-ITLQQWRKAFGVIPQKVFIFSG 1298
Query: 1156 SLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP 1192
+ +N+ D + + EI A + S I P
Sbjct: 1299 TFRKNL---DPYEQWSDQEIWKVADEVGLRSVIEQFP 1332
Score = 40.3 bits (90), Expect = 0.043
Identities = 18/48 (37%), Positives = 30/48 (62%)
Query: 1081 VLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNR 1128
VLK I+ K+E G+ +A+ GS+G GK+++L + +P G I+ R
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGR 487
>DQ388140-1|ABD72207.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 100 bits (239), Expect = 4e-20
Identities = 58/225 (25%), Positives = 110/225 (48%), Gaps = 2/225 (0%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
+L+ S + PG+ V L+G +G GKST+L RL + + W R
Sbjct: 1226 ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQW-RK 1284
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
+ GV+ Q+ +F GT N+ + + +EI +VA+ I P D V+ + G
Sbjct: 1285 AFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGG 1343
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHR 590
LS G KQ + +ARS+L + +LLLDE ++ LDP + + ++ L +A T I HR
Sbjct: 1344 CVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHR 1403
Query: 591 LSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENK 635
+ ++ + + +++ + + + + L+ + + + ++ + K
Sbjct: 1404 IEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVK 1448
Score = 82.2 bits (194), Expect = 1e-14
Identities = 56/220 (25%), Positives = 106/220 (48%), Gaps = 16/220 (7%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
VLK + ++ G+ +A+ GS+G GK+++L ++ +P G + SW+
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGRISFCSQFSWIMP 499
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
GTI +NI G + V + + IS + V+GE G
Sbjct: 500 -------------GTIKENIIFGV-SYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGG 545
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVSH 589
+LSGGQ+ RI++AR++ ++ + LLD LD +E+++ ++ + + +T I V+
Sbjct: 546 ITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTS 605
Query: 590 RLSTIVNADRIICMDQGVIVEQGTHEDLMKAK-GFYHKLV 628
++ + AD+I+ + +G GT +L + F KL+
Sbjct: 606 KMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 65.3 bits (152), Expect = 1e-09
Identities = 96/397 (24%), Positives = 166/397 (41%), Gaps = 32/397 (8%)
Query: 816 LRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGF 875
L H+ S+L+ + + T G I R S D A + L I +Q + +V+G
Sbjct: 948 LHHKMLHSVLQAPMSTLN--TLKAGGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGA 1004
Query: 876 LLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIK-- 933
+ ++ VATV P++V I L Q +Q ++ E + I T V S+K
Sbjct: 1005 IAVVAVLQPYIFVATV--PVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGL 1062
Query: 934 -TVQSLGVETVFLQKFQDALK--TACVAVAYKT-RWRGLVYGLGVYIPFMAYCSATVY-- 987
T+++ G + F F AL TA + T RW + + I F+A ++
Sbjct: 1063 WTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTT 1122
Query: 988 -------GAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYA----PSLNT-AKACGAR 1035
G +L + L VN +I + M S V+ P+ K+
Sbjct: 1123 GEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPY 1182
Query: 1036 ILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTI 1095
+ + I N+ VK W + G +++D+ Y T +L+ I + G+ +
Sbjct: 1183 KNGQLSKVMIIENS-HVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRV 1240
Query: 1096 ALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDR 1155
L+G +G GKST+L F R + + G I++D S +T+ + R+ GV+ Q+ +
Sbjct: 1241 GLLGRTGSGKSTLLSAFLRLLNTE-GEIQIDGVSWDS-ITLQQWRKAFGVIPQKVFIFSG 1298
Query: 1156 SLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP 1192
+ +N+ D + + EI A + S I P
Sbjct: 1299 TFRKNL---DPYEQWSDQEIWKVADEVGLRSVIEQFP 1332
Score = 40.7 bits (91), Expect = 0.032
Identities = 18/48 (37%), Positives = 30/48 (62%)
Query: 1081 VLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNR 1128
VLK I+ K+E G+ +A+ GS+G GK+++L + +P G I+ R
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGR 487
>DQ388139-1|ABD72205.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 100 bits (239), Expect = 4e-20
Identities = 58/225 (25%), Positives = 110/225 (48%), Gaps = 2/225 (0%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
+L+ S + PG+ V L+G +G GKST+L RL + + W R
Sbjct: 1226 ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQW-RK 1284
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
+ GV+ Q+ +F GT N+ + + +EI +VA+ I P D V+ + G
Sbjct: 1285 AFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGG 1343
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHR 590
LS G KQ + +ARS+L + +LLLDE ++ LDP + + ++ L +A T I HR
Sbjct: 1344 CVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHR 1403
Query: 591 LSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENK 635
+ ++ + + +++ + + + + L+ + + + ++ + K
Sbjct: 1404 IEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVK 1448
Score = 81.8 bits (193), Expect = 1e-14
Identities = 56/220 (25%), Positives = 106/220 (48%), Gaps = 16/220 (7%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
VLK + ++ G+ +A+ GS+G GK+++L ++ +P G + SW+
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIMP 499
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
GTI +NI G + V + + IS + V+GE G
Sbjct: 500 -------------GTIKENIIFGV-SYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGG 545
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVSH 589
+LSGGQ+ RI++AR++ ++ + LLD LD +E+++ ++ + + +T I V+
Sbjct: 546 ITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTS 605
Query: 590 RLSTIVNADRIICMDQGVIVEQGTHEDLMKAK-GFYHKLV 628
++ + AD+I+ + +G GT +L + F KL+
Sbjct: 606 KMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 65.3 bits (152), Expect = 1e-09
Identities = 96/397 (24%), Positives = 166/397 (41%), Gaps = 32/397 (8%)
Query: 816 LRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGF 875
L H+ S+L+ + + T G I R S D A + L I +Q + +V+G
Sbjct: 948 LHHKMLHSVLQAPMSTLN--TLKAGGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGA 1004
Query: 876 LLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIK-- 933
+ ++ VATV P++V I L Q +Q ++ E + I T V S+K
Sbjct: 1005 IAVVAVLQPYIFVATV--PVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGL 1062
Query: 934 -TVQSLGVETVFLQKFQDALK--TACVAVAYKT-RWRGLVYGLGVYIPFMAYCSATVY-- 987
T+++ G + F F AL TA + T RW + + I F+A ++
Sbjct: 1063 WTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTT 1122
Query: 988 -------GAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYA----PSLNT-AKACGAR 1035
G +L + L VN +I + M S V+ P+ K+
Sbjct: 1123 GEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPY 1182
Query: 1036 ILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTI 1095
+ + I N+ VK W + G +++D+ Y T +L+ I + G+ +
Sbjct: 1183 KNGQLSKVMIIENS-HVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRV 1240
Query: 1096 ALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDR 1155
L+G +G GKST+L F R + + G I++D S +T+ + R+ GV+ Q+ +
Sbjct: 1241 GLLGRTGSGKSTLLSAFLRLLNTE-GEIQIDGVSWDS-ITLQQWRKAFGVIPQKVFIFSG 1298
Query: 1156 SLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP 1192
+ +N+ D + + EI A + S I P
Sbjct: 1299 TFRKNL---DPYEQWSDQEIWKVADEVGLRSVIEQFP 1332
Score = 40.3 bits (90), Expect = 0.043
Identities = 18/48 (37%), Positives = 30/48 (62%)
Query: 1081 VLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNR 1128
VLK I+ K+E G+ +A+ GS+G GK+++L + +P G I+ R
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGR 487
>DQ388138-1|ABD72203.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 100 bits (239), Expect = 4e-20
Identities = 58/225 (25%), Positives = 110/225 (48%), Gaps = 2/225 (0%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
+L+ S + PG+ V L+G +G GKST+L RL + + W R
Sbjct: 1226 ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQW-RK 1284
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
+ GV+ Q+ +F GT N+ + + +EI +VA+ I P D V+ + G
Sbjct: 1285 AFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGG 1343
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHR 590
LS G KQ + +ARS+L + +LLLDE ++ LDP + + ++ L +A T I HR
Sbjct: 1344 CVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHR 1403
Query: 591 LSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENK 635
+ ++ + + +++ + + + + L+ + + + ++ + K
Sbjct: 1404 IEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVK 1448
Score = 82.2 bits (194), Expect = 1e-14
Identities = 56/220 (25%), Positives = 106/220 (48%), Gaps = 16/220 (7%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
VLK + ++ G+ +A+ GS+G GK+++L ++ +P G + SW+
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGRISFCSQFSWIMP 499
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
GTI +NI G + V + + IS + V+GE G
Sbjct: 500 -------------GTIKENIIFGV-SYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGG 545
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVSH 589
+LSGGQ+ RI++AR++ ++ + LLD LD +E+++ ++ + + +T I V+
Sbjct: 546 ITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTS 605
Query: 590 RLSTIVNADRIICMDQGVIVEQGTHEDLMKAK-GFYHKLV 628
++ + AD+I+ + +G GT +L + F KL+
Sbjct: 606 KMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 65.3 bits (152), Expect = 1e-09
Identities = 96/397 (24%), Positives = 166/397 (41%), Gaps = 32/397 (8%)
Query: 816 LRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGF 875
L H+ S+L+ + + T G I R S D A + L I +Q + +V+G
Sbjct: 948 LHHKMLHSVLQAPMSTLN--TLKAGGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGA 1004
Query: 876 LLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIK-- 933
+ ++ VATV P++V I L Q +Q ++ E + I T V S+K
Sbjct: 1005 IAVVAVLQPYIFVATV--PVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGL 1062
Query: 934 -TVQSLGVETVFLQKFQDALK--TACVAVAYKT-RWRGLVYGLGVYIPFMAYCSATVY-- 987
T+++ G + F F AL TA + T RW + + I F+A ++
Sbjct: 1063 WTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTT 1122
Query: 988 -------GAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYA----PSLNT-AKACGAR 1035
G +L + L VN +I + M S V+ P+ K+
Sbjct: 1123 GEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPY 1182
Query: 1036 ILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTI 1095
+ + I N+ VK W + G +++D+ Y T +L+ I + G+ +
Sbjct: 1183 KNGQLSKVMIIENS-HVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRV 1240
Query: 1096 ALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDR 1155
L+G +G GKST+L F R + + G I++D S +T+ + R+ GV+ Q+ +
Sbjct: 1241 GLLGRTGSGKSTLLSAFLRLLNTE-GEIQIDGVSWDS-ITLQQWRKAFGVIPQKVFIFSG 1298
Query: 1156 SLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP 1192
+ +N+ D + + EI A + S I P
Sbjct: 1299 TFRKNL---DPYEQWSDQEIWKVADEVGLRSVIEQFP 1332
Score = 40.7 bits (91), Expect = 0.032
Identities = 18/48 (37%), Positives = 30/48 (62%)
Query: 1081 VLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNR 1128
VLK I+ K+E G+ +A+ GS+G GK+++L + +P G I+ R
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGR 487
>DQ388137-1|ABD72201.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 100 bits (239), Expect = 4e-20
Identities = 58/225 (25%), Positives = 110/225 (48%), Gaps = 2/225 (0%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
+L+ S + PG+ V L+G +G GKST+L RL + + W R
Sbjct: 1226 ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQW-RK 1284
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
+ GV+ Q+ +F GT N+ + + +EI +VA+ I P D V+ + G
Sbjct: 1285 AFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGG 1343
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHR 590
LS G KQ + +ARS+L + +LLLDE ++ LDP + + ++ L +A T I HR
Sbjct: 1344 CVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHR 1403
Query: 591 LSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENK 635
+ ++ + + +++ + + + + L+ + + + ++ + K
Sbjct: 1404 IEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVK 1448
Score = 82.2 bits (194), Expect = 1e-14
Identities = 56/220 (25%), Positives = 106/220 (48%), Gaps = 16/220 (7%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
VLK + ++ G+ +A+ GS+G GK+++L ++ +P G + SW+
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGRISFCSQFSWIMP 499
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
GTI +NI G + V + + IS + V+GE G
Sbjct: 500 -------------GTIKENIIFGV-SYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGG 545
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVSH 589
+LSGGQ+ RI++AR++ ++ + LLD LD +E+++ ++ + + +T I V+
Sbjct: 546 ITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTS 605
Query: 590 RLSTIVNADRIICMDQGVIVEQGTHEDLMKAK-GFYHKLV 628
++ + AD+I+ + +G GT +L + F KL+
Sbjct: 606 KMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 65.3 bits (152), Expect = 1e-09
Identities = 96/397 (24%), Positives = 166/397 (41%), Gaps = 32/397 (8%)
Query: 816 LRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGF 875
L H+ S+L+ + + T G I R S D A + L I +Q + +V+G
Sbjct: 948 LHHKMLHSVLQAPMSTLN--TLKAGGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGA 1004
Query: 876 LLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIK-- 933
+ ++ VATV P++V I L Q +Q ++ E + I T V S+K
Sbjct: 1005 IAVVAVLQPYIFVATV--PVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGL 1062
Query: 934 -TVQSLGVETVFLQKFQDALK--TACVAVAYKT-RWRGLVYGLGVYIPFMAYCSATVY-- 987
T+++ G + F F AL TA + T RW + + I F+A ++
Sbjct: 1063 WTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTT 1122
Query: 988 -------GAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYA----PSLNT-AKACGAR 1035
G +L + L VN +I + M S V+ P+ K+
Sbjct: 1123 GEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPY 1182
Query: 1036 ILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTI 1095
+ + I N+ VK W + G +++D+ Y T +L+ I + G+ +
Sbjct: 1183 KNGQLSKVMIIENS-HVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRV 1240
Query: 1096 ALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDR 1155
L+G +G GKST+L F R + + G I++D S +T+ + R+ GV+ Q+ +
Sbjct: 1241 GLLGRTGSGKSTLLSAFLRLLNTE-GEIQIDGVSWDS-ITLQQWRKAFGVIPQKVFIFSG 1298
Query: 1156 SLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP 1192
+ +N+ D + + EI A + S I P
Sbjct: 1299 TFRKNL---DPYEQWSDQEIWKVADEVGLRSVIEQFP 1332
Score = 40.7 bits (91), Expect = 0.032
Identities = 18/48 (37%), Positives = 30/48 (62%)
Query: 1081 VLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNR 1128
VLK I+ K+E G+ +A+ GS+G GK+++L + +P G I+ R
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGR 487
>DQ388135-1|ABD72197.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 100 bits (239), Expect = 4e-20
Identities = 58/225 (25%), Positives = 110/225 (48%), Gaps = 2/225 (0%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
+L+ S + PG+ V L+G +G GKST+L RL + + W R
Sbjct: 1226 ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQW-RK 1284
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
+ GV+ Q+ +F GT N+ + + +EI +VA+ I P D V+ + G
Sbjct: 1285 AFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGG 1343
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHR 590
LS G KQ + +ARS+L + +LLLDE ++ LDP + + ++ L +A T I HR
Sbjct: 1344 CVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHR 1403
Query: 591 LSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENK 635
+ ++ + + +++ + + + + L+ + + + ++ + K
Sbjct: 1404 IEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVK 1448
Score = 82.2 bits (194), Expect = 1e-14
Identities = 56/220 (25%), Positives = 106/220 (48%), Gaps = 16/220 (7%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
VLK + ++ G+ +A+ GS+G GK+++L ++ +P G + SW+
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGRISFCSQFSWIMP 499
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
GTI +NI G + V + + IS + V+GE G
Sbjct: 500 -------------GTIKENIIFGV-SYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGG 545
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVSH 589
+LSGGQ+ RI++AR++ ++ + LLD LD +E+++ ++ + + +T I V+
Sbjct: 546 ITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTS 605
Query: 590 RLSTIVNADRIICMDQGVIVEQGTHEDLMKAK-GFYHKLV 628
++ + AD+I+ + +G GT +L + F KL+
Sbjct: 606 KMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 65.3 bits (152), Expect = 1e-09
Identities = 96/397 (24%), Positives = 166/397 (41%), Gaps = 32/397 (8%)
Query: 816 LRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGF 875
L H+ S+L+ + + T G I R S D A + L I +Q + +V+G
Sbjct: 948 LHHKMLHSVLQAPMSTLN--TLKAGGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGA 1004
Query: 876 LLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIK-- 933
+ ++ VATV P++V I L Q +Q ++ E + I T V S+K
Sbjct: 1005 IAVVAVLQPYIFVATV--PVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGL 1062
Query: 934 -TVQSLGVETVFLQKFQDALK--TACVAVAYKT-RWRGLVYGLGVYIPFMAYCSATVY-- 987
T+++ G + F F AL TA + T RW + + I F+A ++
Sbjct: 1063 WTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTT 1122
Query: 988 -------GAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYA----PSLNT-AKACGAR 1035
G +L + L VN +I + M S V+ P+ K+
Sbjct: 1123 GEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPY 1182
Query: 1036 ILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTI 1095
+ + I N+ VK W + G +++D+ Y T +L+ I + G+ +
Sbjct: 1183 KNGQLSKVMIIENS-HVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRV 1240
Query: 1096 ALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDR 1155
L+G +G GKST+L F R + + G I++D S +T+ + R+ GV+ Q+ +
Sbjct: 1241 GLLGRTGSGKSTLLSAFLRLLNTE-GEIQIDGVSWDS-ITLQQWRKAFGVIPQKVFIFSG 1298
Query: 1156 SLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP 1192
+ +N+ D + + EI A + S I P
Sbjct: 1299 TFRKNL---DPYEQWSDQEIWKVADEVGLRSVIEQFP 1332
Score = 40.7 bits (91), Expect = 0.032
Identities = 18/48 (37%), Positives = 30/48 (62%)
Query: 1081 VLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNR 1128
VLK I+ K+E G+ +A+ GS+G GK+++L + +P G I+ R
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGR 487
>DQ388134-1|ABD72195.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 100 bits (239), Expect = 4e-20
Identities = 58/225 (25%), Positives = 110/225 (48%), Gaps = 2/225 (0%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
+L+ S + PG+ V L+G +G GKST+L RL + + W R
Sbjct: 1226 ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQW-RK 1284
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
+ GV+ Q+ +F GT N+ + + +EI +VA+ I P D V+ + G
Sbjct: 1285 AFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGG 1343
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHR 590
LS G KQ + +ARS+L + +LLLDE ++ LDP + + ++ L +A T I HR
Sbjct: 1344 CVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHR 1403
Query: 591 LSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENK 635
+ ++ + + +++ + + + + L+ + + + ++ + K
Sbjct: 1404 IEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVK 1448
Score = 81.8 bits (193), Expect = 1e-14
Identities = 56/220 (25%), Positives = 106/220 (48%), Gaps = 16/220 (7%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
VLK + ++ G+ +A+ GS+G GK+++L ++ +P G + SW+
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIMP 499
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
GTI +NI G + V + + IS + V+GE G
Sbjct: 500 -------------GTIKENIIFGV-SYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGG 545
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVSH 589
+LSGGQ+ RI++AR++ ++ + LLD LD +E+++ ++ + + +T I V+
Sbjct: 546 ITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTS 605
Query: 590 RLSTIVNADRIICMDQGVIVEQGTHEDLMKAK-GFYHKLV 628
++ + AD+I+ + +G GT +L + F KL+
Sbjct: 606 KMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 65.3 bits (152), Expect = 1e-09
Identities = 96/397 (24%), Positives = 166/397 (41%), Gaps = 32/397 (8%)
Query: 816 LRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGF 875
L H+ S+L+ + + T G I R S D A + L I +Q + +V+G
Sbjct: 948 LHHKMLHSVLQAPMSTLN--TLKAGGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGA 1004
Query: 876 LLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIK-- 933
+ ++ VATV P++V I L Q +Q ++ E + I T V S+K
Sbjct: 1005 IAVVAVLQPYIFVATV--PVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGL 1062
Query: 934 -TVQSLGVETVFLQKFQDALK--TACVAVAYKT-RWRGLVYGLGVYIPFMAYCSATVY-- 987
T+++ G + F F AL TA + T RW + + I F+A ++
Sbjct: 1063 WTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTT 1122
Query: 988 -------GAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYA----PSLNT-AKACGAR 1035
G +L + L VN +I + M S V+ P+ K+
Sbjct: 1123 GEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPY 1182
Query: 1036 ILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTI 1095
+ + I N+ VK W + G +++D+ Y T +L+ I + G+ +
Sbjct: 1183 KNGQLSKVMIIENS-HVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRV 1240
Query: 1096 ALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDR 1155
L+G +G GKST+L F R + + G I++D S +T+ + R+ GV+ Q+ +
Sbjct: 1241 GLLGRTGSGKSTLLSAFLRLLNTE-GEIQIDGVSWDS-ITLQQWRKAFGVIPQKVFIFSG 1298
Query: 1156 SLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP 1192
+ +N+ D + + EI A + S I P
Sbjct: 1299 TFRKNL---DPYEQWSDQEIWKVADEVGLRSVIEQFP 1332
Score = 40.3 bits (90), Expect = 0.043
Identities = 18/48 (37%), Positives = 30/48 (62%)
Query: 1081 VLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNR 1128
VLK I+ K+E G+ +A+ GS+G GK+++L + +P G I+ R
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGR 487
>DQ388133-1|ABD72193.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 100 bits (239), Expect = 4e-20
Identities = 58/225 (25%), Positives = 110/225 (48%), Gaps = 2/225 (0%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
+L+ S + PG+ V L+G +G GKST+L RL + + W R
Sbjct: 1226 ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQW-RK 1284
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
+ GV+ Q+ +F GT N+ + + +EI +VA+ I P D V+ + G
Sbjct: 1285 AFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGG 1343
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHR 590
LS G KQ + +ARS+L + +LLLDE ++ LDP + + ++ L +A T I HR
Sbjct: 1344 CVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHR 1403
Query: 591 LSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENK 635
+ ++ + + +++ + + + + L+ + + + ++ + K
Sbjct: 1404 IEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVK 1448
Score = 82.2 bits (194), Expect = 1e-14
Identities = 56/220 (25%), Positives = 106/220 (48%), Gaps = 16/220 (7%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
VLK + ++ G+ +A+ GS+G GK+++L ++ +P G + SW+
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGRISFCSQFSWIMP 499
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
GTI +NI G + V + + IS + V+GE G
Sbjct: 500 -------------GTIKENIIFGV-SYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGG 545
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVSH 589
+LSGGQ+ RI++AR++ ++ + LLD LD +E+++ ++ + + +T I V+
Sbjct: 546 ITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTS 605
Query: 590 RLSTIVNADRIICMDQGVIVEQGTHEDLMKAK-GFYHKLV 628
++ + AD+I+ + +G GT +L + F KL+
Sbjct: 606 KMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 65.3 bits (152), Expect = 1e-09
Identities = 96/397 (24%), Positives = 166/397 (41%), Gaps = 32/397 (8%)
Query: 816 LRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGF 875
L H+ S+L+ + + T G I R S D A + L I +Q + +V+G
Sbjct: 948 LHHKMLHSVLQAPMSTLN--TLKAGGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGA 1004
Query: 876 LLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIK-- 933
+ ++ VATV P++V I L Q +Q ++ E + I T V S+K
Sbjct: 1005 IAVVAVLQPYIFVATV--PVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGL 1062
Query: 934 -TVQSLGVETVFLQKFQDALK--TACVAVAYKT-RWRGLVYGLGVYIPFMAYCSATVY-- 987
T+++ G + F F AL TA + T RW + + I F+A ++
Sbjct: 1063 WTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTT 1122
Query: 988 -------GAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYA----PSLNT-AKACGAR 1035
G +L + L VN +I + M S V+ P+ K+
Sbjct: 1123 GEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPY 1182
Query: 1036 ILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTI 1095
+ + I N+ VK W + G +++D+ Y T +L+ I + G+ +
Sbjct: 1183 KNGQLSKVMIIENS-HVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRV 1240
Query: 1096 ALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDR 1155
L+G +G GKST+L F R + + G I++D S +T+ + R+ GV+ Q+ +
Sbjct: 1241 GLLGRTGSGKSTLLSAFLRLLNTE-GEIQIDGVSWDS-ITLQQWRKAFGVIPQKVFIFSG 1298
Query: 1156 SLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP 1192
+ +N+ D + + EI A + S I P
Sbjct: 1299 TFRKNL---DPYEQWSDQEIWKVADEVGLRSVIEQFP 1332
Score = 40.7 bits (91), Expect = 0.032
Identities = 18/48 (37%), Positives = 30/48 (62%)
Query: 1081 VLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNR 1128
VLK I+ K+E G+ +A+ GS+G GK+++L + +P G I+ R
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGR 487
>DQ388132-1|ABD72191.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 100 bits (239), Expect = 4e-20
Identities = 58/225 (25%), Positives = 110/225 (48%), Gaps = 2/225 (0%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
+L+ S + PG+ V L+G +G GKST+L RL + + W R
Sbjct: 1226 ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQW-RK 1284
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
+ GV+ Q+ +F GT N+ + + +EI +VA+ I P D V+ + G
Sbjct: 1285 AFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGG 1343
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHR 590
LS G KQ + +ARS+L + +LLLDE ++ LDP + + ++ L +A T I HR
Sbjct: 1344 CVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHR 1403
Query: 591 LSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENK 635
+ ++ + + +++ + + + + L+ + + + ++ + K
Sbjct: 1404 IEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVK 1448
Score = 82.2 bits (194), Expect = 1e-14
Identities = 56/220 (25%), Positives = 106/220 (48%), Gaps = 16/220 (7%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
VLK + ++ G+ +A+ GS+G GK+++L ++ +P G + SW+
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGRISFCSQFSWIMP 499
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
GTI +NI G + V + + IS + V+GE G
Sbjct: 500 -------------GTIKENIIFGV-SYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGG 545
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVSH 589
+LSGGQ+ RI++AR++ ++ + LLD LD +E+++ ++ + + +T I V+
Sbjct: 546 ITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTS 605
Query: 590 RLSTIVNADRIICMDQGVIVEQGTHEDLMKAK-GFYHKLV 628
++ + AD+I+ + +G GT +L + F KL+
Sbjct: 606 KMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 65.3 bits (152), Expect = 1e-09
Identities = 96/397 (24%), Positives = 166/397 (41%), Gaps = 32/397 (8%)
Query: 816 LRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGF 875
L H+ S+L+ + + T G I R S D A + L I +Q + +V+G
Sbjct: 948 LHHKMLHSVLQAPMSTLN--TLKAGGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGA 1004
Query: 876 LLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIK-- 933
+ ++ VATV P++V I L Q +Q ++ E + I T V S+K
Sbjct: 1005 IAVVAVLQPYIFVATV--PVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGL 1062
Query: 934 -TVQSLGVETVFLQKFQDALK--TACVAVAYKT-RWRGLVYGLGVYIPFMAYCSATVY-- 987
T+++ G + F F AL TA + T RW + + I F+A ++
Sbjct: 1063 WTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTT 1122
Query: 988 -------GAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYA----PSLNT-AKACGAR 1035
G +L + L VN +I + M S V+ P+ K+
Sbjct: 1123 GEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPY 1182
Query: 1036 ILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTI 1095
+ + I N+ VK W + G +++D+ Y T +L+ I + G+ +
Sbjct: 1183 KNGQLSKVMIIENS-HVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRV 1240
Query: 1096 ALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDR 1155
L+G +G GKST+L F R + + G I++D S +T+ + R+ GV+ Q+ +
Sbjct: 1241 GLLGRTGSGKSTLLSAFLRLLNTE-GEIQIDGVSWDS-ITLQQWRKAFGVIPQKVFIFSG 1298
Query: 1156 SLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP 1192
+ +N+ D + + EI A + S I P
Sbjct: 1299 TFRKNL---DPYEQWSDQEIWKVADEVGLRSVIEQFP 1332
Score = 40.7 bits (91), Expect = 0.032
Identities = 18/48 (37%), Positives = 30/48 (62%)
Query: 1081 VLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNR 1128
VLK I+ K+E G+ +A+ GS+G GK+++L + +P G I+ R
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGR 487
>DQ388131-1|ABD72189.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 100 bits (239), Expect = 4e-20
Identities = 58/225 (25%), Positives = 110/225 (48%), Gaps = 2/225 (0%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
+L+ S + PG+ V L+G +G GKST+L RL + + W R
Sbjct: 1226 ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQW-RK 1284
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
+ GV+ Q+ +F GT N+ + + +EI +VA+ I P D V+ + G
Sbjct: 1285 AFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGG 1343
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHR 590
LS G KQ + +ARS+L + +LLLDE ++ LDP + + ++ L +A T I HR
Sbjct: 1344 CVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHR 1403
Query: 591 LSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENK 635
+ ++ + + +++ + + + + L+ + + + ++ + K
Sbjct: 1404 IEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVK 1448
Score = 82.2 bits (194), Expect = 1e-14
Identities = 56/220 (25%), Positives = 106/220 (48%), Gaps = 16/220 (7%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
VLK + ++ G+ +A+ GS+G GK+++L ++ +P G + SW+
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGRISFCSQFSWIMP 499
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
GTI +NI G + V + + IS + V+GE G
Sbjct: 500 -------------GTIKENIIFGV-SYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGG 545
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVSH 589
+LSGGQ+ RI++AR++ ++ + LLD LD +E+++ ++ + + +T I V+
Sbjct: 546 ITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTS 605
Query: 590 RLSTIVNADRIICMDQGVIVEQGTHEDLMKAK-GFYHKLV 628
++ + AD+I+ + +G GT +L + F KL+
Sbjct: 606 KMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 65.3 bits (152), Expect = 1e-09
Identities = 96/397 (24%), Positives = 166/397 (41%), Gaps = 32/397 (8%)
Query: 816 LRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGF 875
L H+ S+L+ + + T G I R S D A + L I +Q + +V+G
Sbjct: 948 LHHKMLHSVLQAPMSTLN--TLKAGGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGA 1004
Query: 876 LLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIK-- 933
+ ++ VATV P++V I L Q +Q ++ E + I T V S+K
Sbjct: 1005 IAVVAVLQPYIFVATV--PVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGL 1062
Query: 934 -TVQSLGVETVFLQKFQDALK--TACVAVAYKT-RWRGLVYGLGVYIPFMAYCSATVY-- 987
T+++ G + F F AL TA + T RW + + I F+A ++
Sbjct: 1063 WTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTT 1122
Query: 988 -------GAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYA----PSLNT-AKACGAR 1035
G +L + L VN +I + M S V+ P+ K+
Sbjct: 1123 GEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPY 1182
Query: 1036 ILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTI 1095
+ + I N+ VK W + G +++D+ Y T +L+ I + G+ +
Sbjct: 1183 KNGQLSKVMIIENS-HVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRV 1240
Query: 1096 ALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDR 1155
L+G +G GKST+L F R + + G I++D S +T+ + R+ GV+ Q+ +
Sbjct: 1241 GLLGRTGSGKSTLLSAFLRLLNTE-GEIQIDGVSWDS-ITLQQWRKAFGVIPQKVFIFSG 1298
Query: 1156 SLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP 1192
+ +N+ D + + EI A + S I P
Sbjct: 1299 TFRKNL---DPYEQWSDQEIWKVADEVGLRSVIEQFP 1332
Score = 40.7 bits (91), Expect = 0.032
Identities = 18/48 (37%), Positives = 30/48 (62%)
Query: 1081 VLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNR 1128
VLK I+ K+E G+ +A+ GS+G GK+++L + +P G I+ R
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGR 487
>DQ388130-1|ABD72187.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 100 bits (239), Expect = 4e-20
Identities = 58/225 (25%), Positives = 110/225 (48%), Gaps = 2/225 (0%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
+L+ S + PG+ V L+G +G GKST+L RL + + W R
Sbjct: 1226 ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQW-RK 1284
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
+ GV+ Q+ +F GT N+ + + +EI +VA+ I P D V+ + G
Sbjct: 1285 AFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGG 1343
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHR 590
LS G KQ + +ARS+L + +LLLDE ++ LDP + + ++ L +A T I HR
Sbjct: 1344 CVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHR 1403
Query: 591 LSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENK 635
+ ++ + + +++ + + + + L+ + + + ++ + K
Sbjct: 1404 IEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVK 1448
Score = 82.2 bits (194), Expect = 1e-14
Identities = 56/220 (25%), Positives = 106/220 (48%), Gaps = 16/220 (7%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
VLK + ++ G+ +A+ GS+G GK+++L ++ +P G + SW+
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGRISFCSQFSWIMP 499
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
GTI +NI G + V + + IS + V+GE G
Sbjct: 500 -------------GTIKENIIFGV-SYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGG 545
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVSH 589
+LSGGQ+ RI++AR++ ++ + LLD LD +E+++ ++ + + +T I V+
Sbjct: 546 ITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTS 605
Query: 590 RLSTIVNADRIICMDQGVIVEQGTHEDLMKAK-GFYHKLV 628
++ + AD+I+ + +G GT +L + F KL+
Sbjct: 606 KMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 65.3 bits (152), Expect = 1e-09
Identities = 96/397 (24%), Positives = 166/397 (41%), Gaps = 32/397 (8%)
Query: 816 LRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGF 875
L H+ S+L+ + + T G I R S D A + L I +Q + +V+G
Sbjct: 948 LHHKMLHSVLQAPMSTLN--TLKAGGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGA 1004
Query: 876 LLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIK-- 933
+ ++ VATV P++V I L Q +Q ++ E + I T V S+K
Sbjct: 1005 IAVVAVLQPYIFVATV--PVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGL 1062
Query: 934 -TVQSLGVETVFLQKFQDALK--TACVAVAYKT-RWRGLVYGLGVYIPFMAYCSATVY-- 987
T+++ G + F F AL TA + T RW + + I F+A ++
Sbjct: 1063 WTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTT 1122
Query: 988 -------GAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYA----PSLNT-AKACGAR 1035
G +L + L VN +I + M S V+ P+ K+
Sbjct: 1123 GEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPY 1182
Query: 1036 ILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTI 1095
+ + I N+ VK W + G +++D+ Y T +L+ I + G+ +
Sbjct: 1183 KNGQLSKVMIIENS-HVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRV 1240
Query: 1096 ALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDR 1155
L+G +G GKST+L F R + + G I++D S +T+ + R+ GV+ Q+ +
Sbjct: 1241 GLLGRTGSGKSTLLSAFLRLLNTE-GEIQIDGVSWDS-ITLQQWRKAFGVIPQKVFIFSG 1298
Query: 1156 SLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP 1192
+ +N+ D + + EI A + S I P
Sbjct: 1299 TFRKNL---DPYEQWSDQEIWKVADEVGLRSVIEQFP 1332
Score = 40.7 bits (91), Expect = 0.032
Identities = 18/48 (37%), Positives = 30/48 (62%)
Query: 1081 VLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNR 1128
VLK I+ K+E G+ +A+ GS+G GK+++L + +P G I+ R
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGR 487
>DQ388129-1|ABD72185.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 100 bits (239), Expect = 4e-20
Identities = 58/225 (25%), Positives = 110/225 (48%), Gaps = 2/225 (0%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
+L+ S + PG+ V L+G +G GKST+L RL + + W R
Sbjct: 1226 ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQW-RK 1284
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
+ GV+ Q+ +F GT N+ + + +EI +VA+ I P D V+ + G
Sbjct: 1285 AFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGG 1343
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHR 590
LS G KQ + +ARS+L + +LLLDE ++ LDP + + ++ L +A T I HR
Sbjct: 1344 CVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHR 1403
Query: 591 LSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENK 635
+ ++ + + +++ + + + + L+ + + + ++ + K
Sbjct: 1404 IEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVK 1448
Score = 82.2 bits (194), Expect = 1e-14
Identities = 56/220 (25%), Positives = 106/220 (48%), Gaps = 16/220 (7%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
VLK + ++ G+ +A+ GS+G GK+++L ++ +P G + SW+
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGRISFCSQFSWIMP 499
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
GTI +NI G + V + + IS + V+GE G
Sbjct: 500 -------------GTIKENIIFGV-SYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGG 545
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVSH 589
+LSGGQ+ RI++AR++ ++ + LLD LD +E+++ ++ + + +T I V+
Sbjct: 546 ITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTS 605
Query: 590 RLSTIVNADRIICMDQGVIVEQGTHEDLMKAK-GFYHKLV 628
++ + AD+I+ + +G GT +L + F KL+
Sbjct: 606 KMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 65.3 bits (152), Expect = 1e-09
Identities = 96/397 (24%), Positives = 166/397 (41%), Gaps = 32/397 (8%)
Query: 816 LRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGF 875
L H+ S+L+ + + T G I R S D A + L I +Q + +V+G
Sbjct: 948 LHHKMLHSVLQAPMSTLN--TLKAGGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGA 1004
Query: 876 LLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIK-- 933
+ ++ VATV P++V I L Q +Q ++ E + I T V S+K
Sbjct: 1005 IAVVAVLQPYIFVATV--PVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGL 1062
Query: 934 -TVQSLGVETVFLQKFQDALK--TACVAVAYKT-RWRGLVYGLGVYIPFMAYCSATVY-- 987
T+++ G + F F AL TA + T RW + + I F+A ++
Sbjct: 1063 WTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTT 1122
Query: 988 -------GAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYA----PSLNT-AKACGAR 1035
G +L + L VN +I + M S V+ P+ K+
Sbjct: 1123 GEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPY 1182
Query: 1036 ILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTI 1095
+ + I N+ VK W + G +++D+ Y T +L+ I + G+ +
Sbjct: 1183 KNGQLSKVMIIENS-HVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRV 1240
Query: 1096 ALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDR 1155
L+G +G GKST+L F R + + G I++D S +T+ + R+ GV+ Q+ +
Sbjct: 1241 GLLGRTGSGKSTLLSAFLRLLNTE-GEIQIDGVSWDS-ITLQQWRKAFGVIPQKVFIFSG 1298
Query: 1156 SLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP 1192
+ +N+ D + + EI A + S I P
Sbjct: 1299 TFRKNL---DPYEQWSDQEIWKVADEVGLRSVIEQFP 1332
Score = 40.7 bits (91), Expect = 0.032
Identities = 18/48 (37%), Positives = 30/48 (62%)
Query: 1081 VLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNR 1128
VLK I+ K+E G+ +A+ GS+G GK+++L + +P G I+ R
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGR 487
>DQ388128-1|ABD72183.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 100 bits (239), Expect = 4e-20
Identities = 58/225 (25%), Positives = 110/225 (48%), Gaps = 2/225 (0%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
+L+ S + PG+ V L+G +G GKST+L RL + + W R
Sbjct: 1226 ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQW-RK 1284
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
+ GV+ Q+ +F GT N+ + + +EI +VA+ I P D V+ + G
Sbjct: 1285 AFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGG 1343
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHR 590
LS G KQ + +ARS+L + +LLLDE ++ LDP + + ++ L +A T I HR
Sbjct: 1344 CVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHR 1403
Query: 591 LSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENK 635
+ ++ + + +++ + + + + L+ + + + ++ + K
Sbjct: 1404 IEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVK 1448
Score = 82.2 bits (194), Expect = 1e-14
Identities = 56/220 (25%), Positives = 106/220 (48%), Gaps = 16/220 (7%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
VLK + ++ G+ +A+ GS+G GK+++L ++ +P G + SW+
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGRISFCSQFSWIMP 499
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
GTI +NI G + V + + IS + V+GE G
Sbjct: 500 -------------GTIKENIIFGV-SYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGG 545
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVSH 589
+LSGGQ+ RI++AR++ ++ + LLD LD +E+++ ++ + + +T I V+
Sbjct: 546 ITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTS 605
Query: 590 RLSTIVNADRIICMDQGVIVEQGTHEDLMKAK-GFYHKLV 628
++ + AD+I+ + +G GT +L + F KL+
Sbjct: 606 KMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 65.3 bits (152), Expect = 1e-09
Identities = 96/397 (24%), Positives = 166/397 (41%), Gaps = 32/397 (8%)
Query: 816 LRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGF 875
L H+ S+L+ + + T G I R S D A + L I +Q + +V+G
Sbjct: 948 LHHKMLHSVLQAPMSTLN--TLKAGGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGA 1004
Query: 876 LLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIK-- 933
+ ++ VATV P++V I L Q +Q ++ E + I T V S+K
Sbjct: 1005 IAVVAVLQPYIFVATV--PVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGL 1062
Query: 934 -TVQSLGVETVFLQKFQDALK--TACVAVAYKT-RWRGLVYGLGVYIPFMAYCSATVY-- 987
T+++ G + F F AL TA + T RW + + I F+A ++
Sbjct: 1063 WTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTT 1122
Query: 988 -------GAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYA----PSLNT-AKACGAR 1035
G +L + L VN +I + M S V+ P+ K+
Sbjct: 1123 GEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPY 1182
Query: 1036 ILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTI 1095
+ + I N+ VK W + G +++D+ Y T +L+ I + G+ +
Sbjct: 1183 KNGQLSKVMIIENS-HVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRV 1240
Query: 1096 ALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDR 1155
L+G +G GKST+L F R + + G I++D S +T+ + R+ GV+ Q+ +
Sbjct: 1241 GLLGRTGSGKSTLLSAFLRLLNTE-GEIQIDGVSWDS-ITLQQWRKAFGVIPQKVFIFSG 1298
Query: 1156 SLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP 1192
+ +N+ D + + EI A + S I P
Sbjct: 1299 TFRKNL---DPYEQWSDQEIWKVADEVGLRSVIEQFP 1332
Score = 40.7 bits (91), Expect = 0.032
Identities = 18/48 (37%), Positives = 30/48 (62%)
Query: 1081 VLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNR 1128
VLK I+ K+E G+ +A+ GS+G GK+++L + +P G I+ R
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGR 487
>DQ356264-1|ABC87067.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 100 bits (239), Expect = 4e-20
Identities = 58/225 (25%), Positives = 110/225 (48%), Gaps = 2/225 (0%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
+L+ S + PG+ V L+G +G GKST+L RL + + W R
Sbjct: 1226 ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQW-RK 1284
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
+ GV+ Q+ +F GT N+ + + +EI +VA+ I P D V+ + G
Sbjct: 1285 AFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGG 1343
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHR 590
LS G KQ + +ARS+L + +LLLDE ++ LDP + + ++ L +A T I HR
Sbjct: 1344 CVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHR 1403
Query: 591 LSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENK 635
+ ++ + + +++ + + + + L+ + + + ++ + K
Sbjct: 1404 IEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVK 1448
Score = 82.2 bits (194), Expect = 1e-14
Identities = 56/220 (25%), Positives = 106/220 (48%), Gaps = 16/220 (7%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
VLK + ++ G+ +A+ GS+G GK+++L ++ +P G + SW+
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGRISFCSQFSWIMP 499
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
GTI +NI G + V + + IS + V+GE G
Sbjct: 500 -------------GTIKENIIFGV-SYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGG 545
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVSH 589
+LSGGQ+ RI++AR++ ++ + LLD LD +E+++ ++ + + +T I V+
Sbjct: 546 ITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTS 605
Query: 590 RLSTIVNADRIICMDQGVIVEQGTHEDLMKAK-GFYHKLV 628
++ + AD+I+ + +G GT +L + F KL+
Sbjct: 606 KMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 65.3 bits (152), Expect = 1e-09
Identities = 96/397 (24%), Positives = 166/397 (41%), Gaps = 32/397 (8%)
Query: 816 LRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGF 875
L H+ S+L+ + + T G I R S D A + L I +Q + +V+G
Sbjct: 948 LHHKMLHSVLQAPMSTLN--TLKAGGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGA 1004
Query: 876 LLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIK-- 933
+ ++ VATV P++V I L Q +Q ++ E + I T V S+K
Sbjct: 1005 IAVVAVLQPYIFVATV--PVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGL 1062
Query: 934 -TVQSLGVETVFLQKFQDALK--TACVAVAYKT-RWRGLVYGLGVYIPFMAYCSATVY-- 987
T+++ G + F F AL TA + T RW + + I F+A ++
Sbjct: 1063 WTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTT 1122
Query: 988 -------GAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYA----PSLNT-AKACGAR 1035
G +L + L VN +I + M S V+ P+ K+
Sbjct: 1123 GEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPY 1182
Query: 1036 ILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTI 1095
+ + I N+ VK W + G +++D+ Y T +L+ I + G+ +
Sbjct: 1183 KNGQLSKVMIIENS-HVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRV 1240
Query: 1096 ALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDR 1155
L+G +G GKST+L F R + + G I++D S +T+ + R+ GV+ Q+ +
Sbjct: 1241 GLLGRTGSGKSTLLSAFLRLLNTE-GEIQIDGVSWDS-ITLQQWRKAFGVIPQKVFIFSG 1298
Query: 1156 SLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP 1192
+ +N+ D + + EI A + S I P
Sbjct: 1299 TFRKNL---DPYEQWSDQEIWKVADEVGLRSVIEQFP 1332
Score = 40.7 bits (91), Expect = 0.032
Identities = 18/48 (37%), Positives = 30/48 (62%)
Query: 1081 VLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNR 1128
VLK I+ K+E G+ +A+ GS+G GK+++L + +P G I+ R
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGR 487
>DQ356263-1|ABC87065.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 100 bits (239), Expect = 4e-20
Identities = 58/225 (25%), Positives = 110/225 (48%), Gaps = 2/225 (0%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
+L+ S + PG+ V L+G +G GKST+L RL + + W R
Sbjct: 1226 ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQW-RK 1284
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
+ GV+ Q+ +F GT N+ + + +EI +VA+ I P D V+ + G
Sbjct: 1285 AFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGG 1343
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHR 590
LS G KQ + +ARS+L + +LLLDE ++ LDP + + ++ L +A T I HR
Sbjct: 1344 CVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHR 1403
Query: 591 LSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENK 635
+ ++ + + +++ + + + + L+ + + + ++ + K
Sbjct: 1404 IEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVK 1448
Score = 82.2 bits (194), Expect = 1e-14
Identities = 56/220 (25%), Positives = 106/220 (48%), Gaps = 16/220 (7%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
VLK + ++ G+ +A+ GS+G GK+++L ++ +P G + SW+
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGRISFCSQFSWIMP 499
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
GTI +NI G + V + + IS + V+GE G
Sbjct: 500 -------------GTIKENIIFGV-SYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGG 545
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVSH 589
+LSGGQ+ RI++AR++ ++ + LLD LD +E+++ ++ + + +T I V+
Sbjct: 546 ITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTS 605
Query: 590 RLSTIVNADRIICMDQGVIVEQGTHEDLMKAK-GFYHKLV 628
++ + AD+I+ + +G GT +L + F KL+
Sbjct: 606 KMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 65.3 bits (152), Expect = 1e-09
Identities = 96/397 (24%), Positives = 166/397 (41%), Gaps = 32/397 (8%)
Query: 816 LRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGF 875
L H+ S+L+ + + T G I R S D A + L I +Q + +V+G
Sbjct: 948 LHHKMLHSVLQAPMSTLN--TLKAGGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGA 1004
Query: 876 LLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIK-- 933
+ ++ VATV P++V I L Q +Q ++ E + I T V S+K
Sbjct: 1005 IAVVAVLQPYIFVATV--PVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGL 1062
Query: 934 -TVQSLGVETVFLQKFQDALK--TACVAVAYKT-RWRGLVYGLGVYIPFMAYCSATVY-- 987
T+++ G + F F AL TA + T RW + + I F+A ++
Sbjct: 1063 WTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTT 1122
Query: 988 -------GAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYA----PSLNT-AKACGAR 1035
G +L + L VN +I + M S V+ P+ K+
Sbjct: 1123 GEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPY 1182
Query: 1036 ILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTI 1095
+ + I N+ VK W + G +++D+ Y T +L+ I + G+ +
Sbjct: 1183 KNGQLSKVMIIENS-HVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRV 1240
Query: 1096 ALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDR 1155
L+G +G GKST+L F R + + G I++D S +T+ + R+ GV+ Q+ +
Sbjct: 1241 GLLGRTGSGKSTLLSAFLRLLNTE-GEIQIDGVSWDS-ITLQQWRKAFGVIPQKVFIFSG 1298
Query: 1156 SLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP 1192
+ +N+ D + + EI A + S I P
Sbjct: 1299 TFRKNL---DPYEQWSDQEIWKVADEVGLRSVIEQFP 1332
Score = 40.7 bits (91), Expect = 0.032
Identities = 18/48 (37%), Positives = 30/48 (62%)
Query: 1081 VLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNR 1128
VLK I+ K+E G+ +A+ GS+G GK+++L + +P G I+ R
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGR 487
>DQ356262-1|ABC87063.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 100 bits (239), Expect = 4e-20
Identities = 58/225 (25%), Positives = 110/225 (48%), Gaps = 2/225 (0%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
+L+ S + PG+ V L+G +G GKST+L RL + + W R
Sbjct: 1226 ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQW-RK 1284
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
+ GV+ Q+ +F GT N+ + + +EI +VA+ I P D V+ + G
Sbjct: 1285 AFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGG 1343
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHR 590
LS G KQ + +ARS+L + +LLLDE ++ LDP + + ++ L +A T I HR
Sbjct: 1344 CVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHR 1403
Query: 591 LSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENK 635
+ ++ + + +++ + + + + L+ + + + ++ + K
Sbjct: 1404 IEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVK 1448
Score = 82.2 bits (194), Expect = 1e-14
Identities = 56/220 (25%), Positives = 106/220 (48%), Gaps = 16/220 (7%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
VLK + ++ G+ +A+ GS+G GK+++L ++ +P G + SW+
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGRISFCSQFSWIMP 499
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
GTI +NI G + V + + IS + V+GE G
Sbjct: 500 -------------GTIKENIIFGV-SYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGG 545
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVSH 589
+LSGGQ+ RI++AR++ ++ + LLD LD +E+++ ++ + + +T I V+
Sbjct: 546 ITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTS 605
Query: 590 RLSTIVNADRIICMDQGVIVEQGTHEDLMKAK-GFYHKLV 628
++ + AD+I+ + +G GT +L + F KL+
Sbjct: 606 KMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 65.3 bits (152), Expect = 1e-09
Identities = 96/397 (24%), Positives = 166/397 (41%), Gaps = 32/397 (8%)
Query: 816 LRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGF 875
L H+ S+L+ + + T G I R S D A + L I +Q + +V+G
Sbjct: 948 LHHKMLHSVLQAPMSTLN--TLKAGGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGA 1004
Query: 876 LLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIK-- 933
+ ++ VATV P++V I L Q +Q ++ E + I T V S+K
Sbjct: 1005 IAVVAVLQPYIFVATV--PVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGL 1062
Query: 934 -TVQSLGVETVFLQKFQDALK--TACVAVAYKT-RWRGLVYGLGVYIPFMAYCSATVY-- 987
T+++ G + F F AL TA + T RW + + I F+A ++
Sbjct: 1063 WTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTT 1122
Query: 988 -------GAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYA----PSLNT-AKACGAR 1035
G +L + L VN +I + M S V+ P+ K+
Sbjct: 1123 GEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPY 1182
Query: 1036 ILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTI 1095
+ + I N+ VK W + G +++D+ Y T +L+ I + G+ +
Sbjct: 1183 KNGQLSKVMIIENS-HVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRV 1240
Query: 1096 ALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDR 1155
L+G +G GKST+L F R + + G I++D S +T+ + R+ GV+ Q+ +
Sbjct: 1241 GLLGRTGSGKSTLLSAFLRLLNTE-GEIQIDGVSWDS-ITLQQWRKAFGVIPQKVFIFSG 1298
Query: 1156 SLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP 1192
+ +N+ D + + EI A + S I P
Sbjct: 1299 TFRKNL---DPYEQWSDQEIWKVADEVGLRSVIEQFP 1332
Score = 40.7 bits (91), Expect = 0.032
Identities = 18/48 (37%), Positives = 30/48 (62%)
Query: 1081 VLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNR 1128
VLK I+ K+E G+ +A+ GS+G GK+++L + +P G I+ R
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGR 487
>DQ356261-1|ABC87061.1| 1462|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1462
Score = 100 bits (239), Expect = 4e-20
Identities = 58/225 (25%), Positives = 110/225 (48%), Gaps = 2/225 (0%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
+L+ S + PG+ V L+G +G GKST+L RL + + W R
Sbjct: 1208 ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQW-RK 1266
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
+ GV+ Q+ +F GT N+ + + +EI +VA+ I P D V+ + G
Sbjct: 1267 AFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGG 1325
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHR 590
LS G KQ + +ARS+L + +LLLDE ++ LDP + + ++ L +A T I HR
Sbjct: 1326 CVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHR 1385
Query: 591 LSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENK 635
+ ++ + + +++ + + + + L+ + + + ++ + K
Sbjct: 1386 IEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVK 1430
Score = 82.2 bits (194), Expect = 1e-14
Identities = 56/220 (25%), Positives = 106/220 (48%), Gaps = 16/220 (7%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
VLK + ++ G+ +A+ GS+G GK+++L ++ +P G + SW+
Sbjct: 422 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGRISFCSQFSWIMP 481
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
GTI +NI G + V + + IS + V+GE G
Sbjct: 482 -------------GTIKENIIFGV-SYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGG 527
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVSH 589
+LSGGQ+ RI++AR++ ++ + LLD LD +E+++ ++ + + +T I V+
Sbjct: 528 ITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTS 587
Query: 590 RLSTIVNADRIICMDQGVIVEQGTHEDLMKAK-GFYHKLV 628
++ + AD+I+ + +G GT +L + F KL+
Sbjct: 588 KMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 627
Score = 65.3 bits (152), Expect = 1e-09
Identities = 96/397 (24%), Positives = 166/397 (41%), Gaps = 32/397 (8%)
Query: 816 LRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGF 875
L H+ S+L+ + + T G I R S D A + L I +Q + +V+G
Sbjct: 930 LHHKMLHSVLQAPMSTLN--TLKAGGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGA 986
Query: 876 LLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIK-- 933
+ ++ VATV P++V I L Q +Q ++ E + I T V S+K
Sbjct: 987 IAVVAVLQPYIFVATV--PVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGL 1044
Query: 934 -TVQSLGVETVFLQKFQDALK--TACVAVAYKT-RWRGLVYGLGVYIPFMAYCSATVY-- 987
T+++ G + F F AL TA + T RW + + I F+A ++
Sbjct: 1045 WTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTT 1104
Query: 988 -------GAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYA----PSLNT-AKACGAR 1035
G +L + L VN +I + M S V+ P+ K+
Sbjct: 1105 GEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPY 1164
Query: 1036 ILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTI 1095
+ + I N+ VK W + G +++D+ Y T +L+ I + G+ +
Sbjct: 1165 KNGQLSKVMIIENS-HVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRV 1222
Query: 1096 ALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDR 1155
L+G +G GKST+L F R + + G I++D S +T+ + R+ GV+ Q+ +
Sbjct: 1223 GLLGRTGSGKSTLLSAFLRLLNTE-GEIQIDGVSWDS-ITLQQWRKAFGVIPQKVFIFSG 1280
Query: 1156 SLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP 1192
+ +N+ D + + EI A + S I P
Sbjct: 1281 TFRKNL---DPYEQWSDQEIWKVADEVGLRSVIEQFP 1314
Score = 40.7 bits (91), Expect = 0.032
Identities = 18/48 (37%), Positives = 30/48 (62%)
Query: 1081 VLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNR 1128
VLK I+ K+E G+ +A+ GS+G GK+++L + +P G I+ R
Sbjct: 422 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGR 469
>DQ356260-1|ABC87059.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 100 bits (239), Expect = 4e-20
Identities = 58/225 (25%), Positives = 110/225 (48%), Gaps = 2/225 (0%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
+L+ S + PG+ V L+G +G GKST+L RL + + W R
Sbjct: 1226 ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQW-RK 1284
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
+ GV+ Q+ +F GT N+ + + +EI +VA+ I P D V+ + G
Sbjct: 1285 AFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGG 1343
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHR 590
LS G KQ + +ARS+L + +LLLDE ++ LDP + + ++ L +A T I HR
Sbjct: 1344 CVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHR 1403
Query: 591 LSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENK 635
+ ++ + + +++ + + + + L+ + + + ++ + K
Sbjct: 1404 IEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVK 1448
Score = 81.8 bits (193), Expect = 1e-14
Identities = 56/220 (25%), Positives = 106/220 (48%), Gaps = 16/220 (7%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
VLK + ++ G+ +A+ GS+G GK+++L ++ +P G + SW+
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIMP 499
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
GTI +NI G + V + + IS + V+GE G
Sbjct: 500 -------------GTIKENIIFGV-SYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGG 545
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVSH 589
+LSGGQ+ RI++AR++ ++ + LLD LD +E+++ ++ + + +T I V+
Sbjct: 546 ITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTS 605
Query: 590 RLSTIVNADRIICMDQGVIVEQGTHEDLMKAK-GFYHKLV 628
++ + AD+I+ + +G GT +L + F KL+
Sbjct: 606 KMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 65.3 bits (152), Expect = 1e-09
Identities = 96/397 (24%), Positives = 166/397 (41%), Gaps = 32/397 (8%)
Query: 816 LRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGF 875
L H+ S+L+ + + T G I R S D A + L I +Q + +V+G
Sbjct: 948 LHHKMLHSVLQAPMSTLN--TLKAGGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGA 1004
Query: 876 LLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIK-- 933
+ ++ VATV P++V I L Q +Q ++ E + I T V S+K
Sbjct: 1005 IAVVAVLQPYIFVATV--PVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGL 1062
Query: 934 -TVQSLGVETVFLQKFQDALK--TACVAVAYKT-RWRGLVYGLGVYIPFMAYCSATVY-- 987
T+++ G + F F AL TA + T RW + + I F+A ++
Sbjct: 1063 WTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTT 1122
Query: 988 -------GAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYA----PSLNT-AKACGAR 1035
G +L + L VN +I + M S V+ P+ K+
Sbjct: 1123 GEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPY 1182
Query: 1036 ILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTI 1095
+ + I N+ VK W + G +++D+ Y T +L+ I + G+ +
Sbjct: 1183 KNGQLSKVMIIENS-HVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRV 1240
Query: 1096 ALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDR 1155
L+G +G GKST+L F R + + G I++D S +T+ + R+ GV+ Q+ +
Sbjct: 1241 GLLGRTGSGKSTLLSAFLRLLNTE-GEIQIDGVSWDS-ITLQQWRKAFGVIPQKVFIFSG 1298
Query: 1156 SLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP 1192
+ +N+ D + + EI A + S I P
Sbjct: 1299 TFRKNL---DPYEQWSDQEIWKVADEVGLRSVIEQFP 1332
Score = 40.3 bits (90), Expect = 0.043
Identities = 18/48 (37%), Positives = 30/48 (62%)
Query: 1081 VLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNR 1128
VLK I+ K+E G+ +A+ GS+G GK+++L + +P G I+ R
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGR 487
>DQ356259-1|ABC87057.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 100 bits (239), Expect = 4e-20
Identities = 58/225 (25%), Positives = 110/225 (48%), Gaps = 2/225 (0%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
+L+ S + PG+ V L+G +G GKST+L RL + + W R
Sbjct: 1226 ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQW-RK 1284
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
+ GV+ Q+ +F GT N+ + + +EI +VA+ I P D V+ + G
Sbjct: 1285 AFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGG 1343
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHR 590
LS G KQ + +ARS+L + +LLLDE ++ LDP + + ++ L +A T I HR
Sbjct: 1344 CVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHR 1403
Query: 591 LSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENK 635
+ ++ + + +++ + + + + L+ + + + ++ + K
Sbjct: 1404 IEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVK 1448
Score = 82.2 bits (194), Expect = 1e-14
Identities = 56/220 (25%), Positives = 106/220 (48%), Gaps = 16/220 (7%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
VLK + ++ G+ +A+ GS+G GK+++L ++ +P G + SW+
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGRISFCSQFSWIMP 499
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
GTI +NI G + V + + IS + V+GE G
Sbjct: 500 -------------GTIKENIIFGV-SYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGG 545
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVSH 589
+LSGGQ+ RI++AR++ ++ + LLD LD +E+++ ++ + + +T I V+
Sbjct: 546 ITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTS 605
Query: 590 RLSTIVNADRIICMDQGVIVEQGTHEDLMKAK-GFYHKLV 628
++ + AD+I+ + +G GT +L + F KL+
Sbjct: 606 KMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 65.3 bits (152), Expect = 1e-09
Identities = 96/397 (24%), Positives = 166/397 (41%), Gaps = 32/397 (8%)
Query: 816 LRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGF 875
L H+ S+L+ + + T G I R S D A + L I +Q + +V+G
Sbjct: 948 LHHKMLHSVLQAPMSTLN--TLKAGGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGA 1004
Query: 876 LLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIK-- 933
+ ++ VATV P++V I L Q +Q ++ E + I T V S+K
Sbjct: 1005 IAVVAVLQPYIFVATV--PVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGL 1062
Query: 934 -TVQSLGVETVFLQKFQDALK--TACVAVAYKT-RWRGLVYGLGVYIPFMAYCSATVY-- 987
T+++ G + F F AL TA + T RW + + I F+A ++
Sbjct: 1063 WTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTT 1122
Query: 988 -------GAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYA----PSLNT-AKACGAR 1035
G +L + L VN +I + M S V+ P+ K+
Sbjct: 1123 GEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPY 1182
Query: 1036 ILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTI 1095
+ + I N+ VK W + G +++D+ Y T +L+ I + G+ +
Sbjct: 1183 KNGQLSKVMIIENS-HVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRV 1240
Query: 1096 ALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDR 1155
L+G +G GKST+L F R + + G I++D S +T+ + R+ GV+ Q+ +
Sbjct: 1241 GLLGRTGSGKSTLLSAFLRLLNTE-GEIQIDGVSWDS-ITLQQWRKAFGVIPQKVFIFSG 1298
Query: 1156 SLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP 1192
+ +N+ D + + EI A + S I P
Sbjct: 1299 TFRKNL---DPYEQWSDQEIWKVADEVGLRSVIEQFP 1332
Score = 40.7 bits (91), Expect = 0.032
Identities = 18/48 (37%), Positives = 30/48 (62%)
Query: 1081 VLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNR 1128
VLK I+ K+E G+ +A+ GS+G GK+++L + +P G I+ R
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGR 487
>DQ356258-1|ABC87055.1| 1462|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1462
Score = 100 bits (239), Expect = 4e-20
Identities = 58/225 (25%), Positives = 110/225 (48%), Gaps = 2/225 (0%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
+L+ S + PG+ V L+G +G GKST+L RL + + W R
Sbjct: 1208 ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQW-RK 1266
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
+ GV+ Q+ +F GT N+ + + +EI +VA+ I P D V+ + G
Sbjct: 1267 AFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGG 1325
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHR 590
LS G KQ + +ARS+L + +LLLDE ++ LDP + + ++ L +A T I HR
Sbjct: 1326 CVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHR 1385
Query: 591 LSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENK 635
+ ++ + + +++ + + + + L+ + + + ++ + K
Sbjct: 1386 IEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVK 1430
Score = 82.2 bits (194), Expect = 1e-14
Identities = 56/220 (25%), Positives = 106/220 (48%), Gaps = 16/220 (7%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
VLK + ++ G+ +A+ GS+G GK+++L ++ +P G + SW+
Sbjct: 422 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGRISFCSQFSWIMP 481
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
GTI +NI G + V + + IS + V+GE G
Sbjct: 482 -------------GTIKENIIFGV-SYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGG 527
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVSH 589
+LSGGQ+ RI++AR++ ++ + LLD LD +E+++ ++ + + +T I V+
Sbjct: 528 ITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTS 587
Query: 590 RLSTIVNADRIICMDQGVIVEQGTHEDLMKAK-GFYHKLV 628
++ + AD+I+ + +G GT +L + F KL+
Sbjct: 588 KMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 627
Score = 65.3 bits (152), Expect = 1e-09
Identities = 96/397 (24%), Positives = 166/397 (41%), Gaps = 32/397 (8%)
Query: 816 LRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGF 875
L H+ S+L+ + + T G I R S D A + L I +Q + +V+G
Sbjct: 930 LHHKMLHSVLQAPMSTLN--TLKAGGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGA 986
Query: 876 LLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIK-- 933
+ ++ VATV P++V I L Q +Q ++ E + I T V S+K
Sbjct: 987 IAVVAVLQPYIFVATV--PVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGL 1044
Query: 934 -TVQSLGVETVFLQKFQDALK--TACVAVAYKT-RWRGLVYGLGVYIPFMAYCSATVY-- 987
T+++ G + F F AL TA + T RW + + I F+A ++
Sbjct: 1045 WTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTT 1104
Query: 988 -------GAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYA----PSLNT-AKACGAR 1035
G +L + L VN +I + M S V+ P+ K+
Sbjct: 1105 GEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPY 1164
Query: 1036 ILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTI 1095
+ + I N+ VK W + G +++D+ Y T +L+ I + G+ +
Sbjct: 1165 KNGQLSKVMIIENS-HVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRV 1222
Query: 1096 ALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDR 1155
L+G +G GKST+L F R + + G I++D S +T+ + R+ GV+ Q+ +
Sbjct: 1223 GLLGRTGSGKSTLLSAFLRLLNTE-GEIQIDGVSWDS-ITLQQWRKAFGVIPQKVFIFSG 1280
Query: 1156 SLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP 1192
+ +N+ D + + EI A + S I P
Sbjct: 1281 TFRKNL---DPYEQWSDQEIWKVADEVGLRSVIEQFP 1314
Score = 40.7 bits (91), Expect = 0.032
Identities = 18/48 (37%), Positives = 30/48 (62%)
Query: 1081 VLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNR 1128
VLK I+ K+E G+ +A+ GS+G GK+++L + +P G I+ R
Sbjct: 422 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGR 469
>DQ356257-1|ABC87053.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 100 bits (239), Expect = 4e-20
Identities = 58/225 (25%), Positives = 110/225 (48%), Gaps = 2/225 (0%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
+L+ S + PG+ V L+G +G GKST+L RL + + W R
Sbjct: 1226 ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQW-RK 1284
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
+ GV+ Q+ +F GT N+ + + +EI +VA+ I P D V+ + G
Sbjct: 1285 AFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGG 1343
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHR 590
LS G KQ + +ARS+L + +LLLDE ++ LDP + + ++ L +A T I HR
Sbjct: 1344 CVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHR 1403
Query: 591 LSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENK 635
+ ++ + + +++ + + + + L+ + + + ++ + K
Sbjct: 1404 IEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVK 1448
Score = 65.3 bits (152), Expect = 1e-09
Identities = 96/397 (24%), Positives = 166/397 (41%), Gaps = 32/397 (8%)
Query: 816 LRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGF 875
L H+ S+L+ + + T G I R S D A + L I +Q + +V+G
Sbjct: 948 LHHKMLHSVLQAPMSTLN--TLKAGGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGA 1004
Query: 876 LLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIK-- 933
+ ++ VATV P++V I L Q +Q ++ E + I T V S+K
Sbjct: 1005 IAVVAVLQPYIFVATV--PVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGL 1062
Query: 934 -TVQSLGVETVFLQKFQDALK--TACVAVAYKT-RWRGLVYGLGVYIPFMAYCSATVY-- 987
T+++ G + F F AL TA + T RW + + I F+A ++
Sbjct: 1063 WTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTT 1122
Query: 988 -------GAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYA----PSLNT-AKACGAR 1035
G +L + L VN +I + M S V+ P+ K+
Sbjct: 1123 GEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPY 1182
Query: 1036 ILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTI 1095
+ + I N+ VK W + G +++D+ Y T +L+ I + G+ +
Sbjct: 1183 KNGQLSKVMIIENS-HVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRV 1240
Query: 1096 ALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDR 1155
L+G +G GKST+L F R + + G I++D S +T+ + R+ GV+ Q+ +
Sbjct: 1241 GLLGRTGSGKSTLLSAFLRLLNTE-GEIQIDGVSWDS-ITLQQWRKAFGVIPQKVFIFSG 1298
Query: 1156 SLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP 1192
+ +N+ D + + EI A + S I P
Sbjct: 1299 TFRKNL---DPYEQWSDQEIWKVADEVGLRSVIEQFP 1332
Score = 45.6 bits (103), Expect = 0.001
Identities = 41/220 (18%), Positives = 85/220 (38%), Gaps = 16/220 (7%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
VLK + ++ G+ +A+ GS+G GK+++L ++ +P G + SW
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGRISFCSQFSW--- 496
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
+ GTI +NI G + V + +
Sbjct: 497 ----------IMPGTIKENIIFG-VSYDEYRYRSVIKACQLEEXXXXXXXXXXXXXXXXX 545
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVSH 589
++ ++ + LLD LD +E+++ ++ + + +T I V+
Sbjct: 546 XXXXXXXXXXXXXXXAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTS 605
Query: 590 RLSTIVNADRIICMDQGVIVEQGTHEDLMKAK-GFYHKLV 628
++ + AD+I+ + +G GT +L + F KL+
Sbjct: 606 KMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 40.7 bits (91), Expect = 0.032
Identities = 18/48 (37%), Positives = 30/48 (62%)
Query: 1081 VLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNR 1128
VLK I+ K+E G+ +A+ GS+G GK+++L + +P G I+ R
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGR 487
>DQ354391-1|ABC79056.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 100 bits (239), Expect = 4e-20
Identities = 58/225 (25%), Positives = 110/225 (48%), Gaps = 2/225 (0%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
+L+ S + PG+ V L+G +G GKST+L RL + + W R
Sbjct: 1226 ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQW-RK 1284
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
+ GV+ Q+ +F GT N+ + + +EI +VA+ I P D V+ + G
Sbjct: 1285 AFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGG 1343
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHR 590
LS G KQ + +ARS+L + +LLLDE ++ LDP + + ++ L +A T I HR
Sbjct: 1344 CVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHR 1403
Query: 591 LSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENK 635
+ ++ + + +++ + + + + L+ + + + ++ + K
Sbjct: 1404 IEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVK 1448
Score = 82.2 bits (194), Expect = 1e-14
Identities = 56/220 (25%), Positives = 106/220 (48%), Gaps = 16/220 (7%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
VLK + ++ G+ +A+ GS+G GK+++L ++ +P G + SW+
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGRISFCSQFSWIMP 499
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
GTI +NI G + V + + IS + V+GE G
Sbjct: 500 -------------GTIKENIIFGV-SYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGG 545
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVSH 589
+LSGGQ+ RI++AR++ ++ + LLD LD +E+++ ++ + + +T I V+
Sbjct: 546 ITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTS 605
Query: 590 RLSTIVNADRIICMDQGVIVEQGTHEDLMKAK-GFYHKLV 628
++ + AD+I+ + +G GT +L + F KL+
Sbjct: 606 KMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 65.3 bits (152), Expect = 1e-09
Identities = 96/397 (24%), Positives = 166/397 (41%), Gaps = 32/397 (8%)
Query: 816 LRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGF 875
L H+ S+L+ + + T G I R S D A + L I +Q + +V+G
Sbjct: 948 LHHKMLHSVLQAPMSTLN--TLKAGGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGA 1004
Query: 876 LLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIK-- 933
+ ++ VATV P++V I L Q +Q ++ E + I T V S+K
Sbjct: 1005 IAVVAVLQPYIFVATV--PVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGL 1062
Query: 934 -TVQSLGVETVFLQKFQDALK--TACVAVAYKT-RWRGLVYGLGVYIPFMAYCSATVY-- 987
T+++ G + F F AL TA + T RW + + I F+A ++
Sbjct: 1063 WTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTT 1122
Query: 988 -------GAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYA----PSLNT-AKACGAR 1035
G +L + L VN +I + M S V+ P+ K+
Sbjct: 1123 GEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPY 1182
Query: 1036 ILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTI 1095
+ + I N+ VK W + G +++D+ Y T +L+ I + G+ +
Sbjct: 1183 KNGQLSKVMIIENS-HVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRV 1240
Query: 1096 ALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDR 1155
L+G +G GKST+L F R + + G I++D S +T+ + R+ GV+ Q+ +
Sbjct: 1241 GLLGRTGSGKSTLLSAFLRLLNTE-GEIQIDGVSWDS-ITLQQWRKAFGVIPQKVFIFSG 1298
Query: 1156 SLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP 1192
+ +N+ D + + EI A + S I P
Sbjct: 1299 TFRKNL---DPYEQWSDQEIWKVADEVGLRSVIEQFP 1332
Score = 40.7 bits (91), Expect = 0.032
Identities = 18/48 (37%), Positives = 30/48 (62%)
Query: 1081 VLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNR 1128
VLK I+ K+E G+ +A+ GS+G GK+++L + +P G I+ R
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGR 487
>DQ354390-1|ABC79054.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 100 bits (239), Expect = 4e-20
Identities = 58/225 (25%), Positives = 110/225 (48%), Gaps = 2/225 (0%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
+L+ S + PG+ V L+G +G GKST+L RL + + W R
Sbjct: 1226 ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQW-RK 1284
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
+ GV+ Q+ +F GT N+ + + +EI +VA+ I P D V+ + G
Sbjct: 1285 AFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGG 1343
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHR 590
LS G KQ + +ARS+L + +LLLDE ++ LDP + + ++ L +A T I HR
Sbjct: 1344 CVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHR 1403
Query: 591 LSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENK 635
+ ++ + + +++ + + + + L+ + + + ++ + K
Sbjct: 1404 IEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVK 1448
Score = 82.2 bits (194), Expect = 1e-14
Identities = 56/220 (25%), Positives = 106/220 (48%), Gaps = 16/220 (7%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
VLK + ++ G+ +A+ GS+G GK+++L ++ +P G + SW+
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGRISFCSQFSWIMP 499
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
GTI +NI G + V + + IS + V+GE G
Sbjct: 500 -------------GTIKENIIFGV-SYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGG 545
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVSH 589
+LSGGQ+ RI++AR++ ++ + LLD LD +E+++ ++ + + +T I V+
Sbjct: 546 ITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTS 605
Query: 590 RLSTIVNADRIICMDQGVIVEQGTHEDLMKAK-GFYHKLV 628
++ + AD+I+ + +G GT +L + F KL+
Sbjct: 606 KMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 65.3 bits (152), Expect = 1e-09
Identities = 96/397 (24%), Positives = 166/397 (41%), Gaps = 32/397 (8%)
Query: 816 LRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGF 875
L H+ S+L+ + + T G I R S D A + L I +Q + +V+G
Sbjct: 948 LHHKMLHSVLQAPMSTLN--TLKAGGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGA 1004
Query: 876 LLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIK-- 933
+ ++ VATV P++V I L Q +Q ++ E + I T V S+K
Sbjct: 1005 IAVVAVLQPYIFVATV--PVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGL 1062
Query: 934 -TVQSLGVETVFLQKFQDALK--TACVAVAYKT-RWRGLVYGLGVYIPFMAYCSATVY-- 987
T+++ G + F F AL TA + T RW + + I F+A ++
Sbjct: 1063 WTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTT 1122
Query: 988 -------GAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYA----PSLNT-AKACGAR 1035
G +L + L VN +I + M S V+ P+ K+
Sbjct: 1123 GEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPY 1182
Query: 1036 ILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTI 1095
+ + I N+ VK W + G +++D+ Y T +L+ I + G+ +
Sbjct: 1183 KNGQLSKVMIIENS-HVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRV 1240
Query: 1096 ALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDR 1155
L+G +G GKST+L F R + + G I++D S +T+ + R+ GV+ Q+ +
Sbjct: 1241 GLLGRTGSGKSTLLSAFLRLLNTE-GEIQIDGVSWDS-ITLQQWRKAFGVIPQKVFIFSG 1298
Query: 1156 SLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP 1192
+ +N+ D + + EI A + S I P
Sbjct: 1299 TFRKNL---DPYEQWSDQEIWKVADEVGLRSVIEQFP 1332
Score = 40.7 bits (91), Expect = 0.032
Identities = 18/48 (37%), Positives = 30/48 (62%)
Query: 1081 VLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNR 1128
VLK I+ K+E G+ +A+ GS+G GK+++L + +P G I+ R
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGR 487
>DQ354389-1|ABC79052.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 100 bits (239), Expect = 4e-20
Identities = 58/225 (25%), Positives = 110/225 (48%), Gaps = 2/225 (0%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
+L+ S + PG+ V L+G +G GKST+L RL + + W R
Sbjct: 1226 ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQW-RK 1284
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
+ GV+ Q+ +F GT N+ + + +EI +VA+ I P D V+ + G
Sbjct: 1285 AFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGG 1343
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHR 590
LS G KQ + +ARS+L + +LLLDE ++ LDP + + ++ L +A T I HR
Sbjct: 1344 CVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHR 1403
Query: 591 LSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENK 635
+ ++ + + +++ + + + + L+ + + + ++ + K
Sbjct: 1404 IEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVK 1448
Score = 82.2 bits (194), Expect = 1e-14
Identities = 56/220 (25%), Positives = 106/220 (48%), Gaps = 16/220 (7%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
VLK + ++ G+ +A+ GS+G GK+++L ++ +P G + SW+
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGRISFCSQFSWIMP 499
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
GTI +NI G + V + + IS + V+GE G
Sbjct: 500 -------------GTIKENIIFGV-SYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGG 545
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVSH 589
+LSGGQ+ RI++AR++ ++ + LLD LD +E+++ ++ + + +T I V+
Sbjct: 546 ITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTS 605
Query: 590 RLSTIVNADRIICMDQGVIVEQGTHEDLMKAK-GFYHKLV 628
++ + AD+I+ + +G GT +L + F KL+
Sbjct: 606 KMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 65.3 bits (152), Expect = 1e-09
Identities = 96/397 (24%), Positives = 166/397 (41%), Gaps = 32/397 (8%)
Query: 816 LRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGF 875
L H+ S+L+ + + T G I R S D A + L I +Q + +V+G
Sbjct: 948 LHHKMLHSVLQAPMSTLN--TLKAGGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGA 1004
Query: 876 LLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIK-- 933
+ ++ VATV P++V I L Q +Q ++ E + I T V S+K
Sbjct: 1005 IAVVAVLQPYIFVATV--PVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGL 1062
Query: 934 -TVQSLGVETVFLQKFQDALK--TACVAVAYKT-RWRGLVYGLGVYIPFMAYCSATVY-- 987
T+++ G + F F AL TA + T RW + + I F+A ++
Sbjct: 1063 WTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTT 1122
Query: 988 -------GAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYA----PSLNT-AKACGAR 1035
G +L + L VN +I + M S V+ P+ K+
Sbjct: 1123 GEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPY 1182
Query: 1036 ILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTI 1095
+ + I N+ VK W + G +++D+ Y T +L+ I + G+ +
Sbjct: 1183 KNGQLSKVMIIENS-HVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRV 1240
Query: 1096 ALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDR 1155
L+G +G GKST+L F R + + G I++D S +T+ + R+ GV+ Q+ +
Sbjct: 1241 GLLGRTGSGKSTLLSAFLRLLNTE-GEIQIDGVSWDS-ITLQQWRKAFGVIPQKVFIFSG 1298
Query: 1156 SLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP 1192
+ +N+ D + + EI A + S I P
Sbjct: 1299 TFRKNL---DPYEQWSDQEIWKVADEVGLRSVIEQFP 1332
Score = 40.7 bits (91), Expect = 0.032
Identities = 18/48 (37%), Positives = 30/48 (62%)
Query: 1081 VLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNR 1128
VLK I+ K+E G+ +A+ GS+G GK+++L + +P G I+ R
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGR 487
>DQ354388-1|ABC79050.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 100 bits (239), Expect = 4e-20
Identities = 58/225 (25%), Positives = 110/225 (48%), Gaps = 2/225 (0%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
+L+ S + PG+ V L+G +G GKST+L RL + + W R
Sbjct: 1226 ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQW-RK 1284
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
+ GV+ Q+ +F GT N+ + + +EI +VA+ I P D V+ + G
Sbjct: 1285 AFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGG 1343
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHR 590
LS G KQ + +ARS+L + +LLLDE ++ LDP + + ++ L +A T I HR
Sbjct: 1344 CVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHR 1403
Query: 591 LSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENK 635
+ ++ + + +++ + + + + L+ + + + ++ + K
Sbjct: 1404 IEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVK 1448
Score = 82.2 bits (194), Expect = 1e-14
Identities = 56/220 (25%), Positives = 106/220 (48%), Gaps = 16/220 (7%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
VLK + ++ G+ +A+ GS+G GK+++L ++ +P G + SW+
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGRISFCSQFSWIMP 499
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
GTI +NI G + V + + IS + V+GE G
Sbjct: 500 -------------GTIKENIIFGV-SYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGG 545
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVSH 589
+LSGGQ+ RI++AR++ ++ + LLD LD +E+++ ++ + + +T I V+
Sbjct: 546 ITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTS 605
Query: 590 RLSTIVNADRIICMDQGVIVEQGTHEDLMKAK-GFYHKLV 628
++ + AD+I+ + +G GT +L + F KL+
Sbjct: 606 KMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 65.3 bits (152), Expect = 1e-09
Identities = 96/397 (24%), Positives = 166/397 (41%), Gaps = 32/397 (8%)
Query: 816 LRHQYFASLLKQEIGFFDKETNTVGAICARLSGDTAEVQGATGLRIGLILQGISSVVVGF 875
L H+ S+L+ + + T G I R S D A + L I +Q + +V+G
Sbjct: 948 LHHKMLHSVLQAPMSTLN--TLKAGGILNRFSKDIAILDDLLPLTIFDFIQ-LLLIVIGA 1004
Query: 876 LLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVVSIK-- 933
+ ++ VATV P++V I L Q +Q ++ E + I T V S+K
Sbjct: 1005 IAVVAVLQPYIFVATV--PVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGL 1062
Query: 934 -TVQSLGVETVFLQKFQDALK--TACVAVAYKT-RWRGLVYGLGVYIPFMAYCSATVY-- 987
T+++ G + F F AL TA + T RW + + I F+A ++
Sbjct: 1063 WTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTT 1122
Query: 988 -------GAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYA----PSLNT-AKACGAR 1035
G +L + L VN +I + M S V+ P+ K+
Sbjct: 1123 GEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPY 1182
Query: 1036 ILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTI 1095
+ + I N+ VK W + G +++D+ Y T +L+ I + G+ +
Sbjct: 1183 KNGQLSKVMIIENS-HVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRV 1240
Query: 1096 ALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDR 1155
L+G +G GKST+L F R + + G I++D S +T+ + R+ GV+ Q+ +
Sbjct: 1241 GLLGRTGSGKSTLLSAFLRLLNTE-GEIQIDGVSWDS-ITLQQWRKAFGVIPQKVFIFSG 1298
Query: 1156 SLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP 1192
+ +N+ D + + EI A + S I P
Sbjct: 1299 TFRKNL---DPYEQWSDQEIWKVADEVGLRSVIEQFP 1332
Score = 40.7 bits (91), Expect = 0.032
Identities = 18/48 (37%), Positives = 30/48 (62%)
Query: 1081 VLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNR 1128
VLK I+ K+E G+ +A+ GS+G GK+++L + +P G I+ R
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGR 487
>AC000061-1|AAB46340.2| 484|Homo sapiens unknown protein.
Length = 484
Score = 100 bits (239), Expect = 4e-20
Identities = 58/225 (25%), Positives = 110/225 (48%), Gaps = 2/225 (0%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
+L+ S + PG+ V L+G +G GKST+L RL + + W R
Sbjct: 230 ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQW-RK 288
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
+ GV+ Q+ +F GT N+ + + +EI +VA+ I P D V+ + G
Sbjct: 289 AFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGG 347
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHR 590
LS G KQ + +ARS+L + +LLLDE ++ LDP + + ++ L +A T I HR
Sbjct: 348 CVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHR 407
Query: 591 LSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENK 635
+ ++ + + +++ + + + + L+ + + + ++ + K
Sbjct: 408 IEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVK 452
Score = 58.8 bits (136), Expect = 1e-07
Identities = 82/342 (23%), Positives = 144/342 (42%), Gaps = 29/342 (8%)
Query: 871 VVVGFLLAISYNWKLTLVATVFLPLMVGSIWLEGIISQKAQIDERNAMESATAIATEAVV 930
+V+G + ++ VATV P++V I L Q +Q ++ E + I T V
Sbjct: 4 IVIGAIAVVAVLQPYIFVATV--PVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVT 61
Query: 931 SIK---TVQSLGVETVFLQKFQDALK--TACVAVAYKT-RWRGLVYGLGVYIPFMAYCSA 984
S+K T+++ G + F F AL TA + T RW + + I F+A
Sbjct: 62 SLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFI 121
Query: 985 TVY---------GAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVYA----PSLNT-AK 1030
++ G +L + L VN +I + M S V+ P+ K
Sbjct: 122 SILTTGEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTK 181
Query: 1031 ACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQRVLKGIDLKME 1090
+ + + I N+ VK W + G +++D+ Y T +L+ I +
Sbjct: 182 STKPYKNGQLSKVMIIENS-HVKKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSIS 239
Query: 1091 AGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEP 1150
G+ + L+G +G GKST+L F R + + G I++D S +T+ + R+ GV+ Q+
Sbjct: 240 PGQRVGLLGRTGSGKSTLLSAFLRLLNTE-GEIQIDGVSWDS-ITLQQWRKAFGVIPQKV 297
Query: 1151 VLLDRSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP 1192
+ + +N+ D + + EI A + S I P
Sbjct: 298 FIFSGTFRKNL---DPYEQWSDQEIWKVADEVGLRSVIEQFP 336
>AF085691-1|AAD02846.1| 1238|Homo sapiens multidrug
resistance-associated protein 3A protein.
Length = 1238
Score = 97.1 bits (231), Expect = 4e-19
Identities = 69/260 (26%), Positives = 121/260 (46%), Gaps = 21/260 (8%)
Query: 412 LKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSS 471
L I V G VA+VG GCGKS+++ L + G V ++ S
Sbjct: 644 LHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVH-------------MKGS 690
Query: 472 LGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGA 531
+ V Q+ + T+ +N+ G + Q + A D + +LP G T IGE+G
Sbjct: 691 VAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLAD-LEMLPGGDQTEIGEKGI 749
Query: 532 SLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV---QAALDRASVGRTTITVS 588
+LSGGQ+QR+++AR++ + + LLD+ SA+D H + + + G+T + V+
Sbjct: 750 NLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVT 809
Query: 589 HRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENKEPADIEPLIEEAD 648
H +S + D II + G + E G + L++ G + + +++ +E +
Sbjct: 810 HGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTALE 869
Query: 649 GDGDN----IEPTVPSRLDV 664
G D IE T+ + D+
Sbjct: 870 GAEDKEALLIEDTLSNHTDL 889
>AY848829-1|AAW33656.1| 258|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
subfam protein.
Length = 258
Score = 93.5 bits (222), Expect = 4e-18
Identities = 56/191 (29%), Positives = 94/191 (49%), Gaps = 2/191 (1%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
+L+ S + PG+ V L+G +G GKST+L RL + + W R
Sbjct: 70 ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQW-RK 128
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
+ GV+ Q+ +F GT N+ + + +EI +VA+ I P D V+ + G
Sbjct: 129 AFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGG 187
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHR 590
LS G KQ + +ARS+L + +LLLDE ++ LDP + + ++ L +A T I HR
Sbjct: 188 CVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHR 247
Query: 591 LSTIVNADRII 601
+ ++ + +
Sbjct: 248 IEAMLECQQFL 258
Score = 54.8 bits (126), Expect = 2e-06
Identities = 38/140 (27%), Positives = 68/140 (48%), Gaps = 8/140 (5%)
Query: 1055 KKD--WVASGNFSMRDVEFCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLF 1112
KKD W + G +++D+ Y T +L+ I + G+ + L+G +G GKST+L F
Sbjct: 43 KKDDIWPSGGQMTVKDLTAKY-TEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAF 101
Query: 1113 QRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENIAYGDNNRKVTM 1172
R + + G I++D S +T+ + R+ GV+ Q+ + + +N+ D + +
Sbjct: 102 LRLLNTE-GEIQIDGVSWDS-ITLQQWRKAFGVIPQKVFIFSGTFRKNL---DPYEQWSD 156
Query: 1173 HEIVAAAKAANIHSFIVSLP 1192
EI A + S I P
Sbjct: 157 QEIWKVADEVGLRSVIEQFP 176
>S83249-1|AAP31917.1| 125|Homo sapiens transporter protein/putative
hormone extrusion pump protein.
Length = 125
Score = 92.7 bits (220), Expect = 8e-18
Identities = 40/96 (41%), Positives = 64/96 (66%)
Query: 535 GGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHRLSTI 594
GGQKQR++IAR ++ P +L D+ TSA+D SE VQ ALD+ G TTI ++ ++S++
Sbjct: 1 GGQKQRLSIARGVVGSPKILFFDDPTSAVDARSENLVQEALDKELAGTTTIVIAEKISSV 60
Query: 595 VNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTT 630
++ADRI+ +D G +V G H +L+ + Y ++ T
Sbjct: 61 LHADRILVLDDGRLVGSGLHAELLASSAIYREIYET 96
Score = 50.4 bits (115), Expect = 4e-05
Identities = 25/54 (46%), Positives = 34/54 (62%)
Query: 1195 VTEALEKAAKGRTCITIAHRLSTVKDADLICVIDKGKIVERGTHAELVSMKGHY 1248
V EAL+K G T I IA ++S+V AD I V+D G++V G HAEL++ Y
Sbjct: 37 VQEALDKELAGTTTIVIAEKISSVLHADRILVLDDGRLVGSGLHAELLASSAIY 90
>AY848830-1|AAW33657.1| 241|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
subfam protein.
Length = 241
Score = 89.8 bits (213), Expect = 5e-17
Identities = 54/211 (25%), Positives = 102/211 (48%), Gaps = 2/211 (0%)
Query: 425 VALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRG 484
V L+G +G GKST+L RL + + W R + GV+ Q+ +F G
Sbjct: 1 VGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQW-RKAFGVIPQKVFIFSG 59
Query: 485 TIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIA 544
T N+ + + +EI +VA+ I P D V+ + G LS G KQ + +A
Sbjct: 60 TFRKNLD-PYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLA 118
Query: 545 RSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNADRIICMD 604
RS+L + +LLLDE ++ LDP + + ++ L +A T I HR+ ++ + + ++
Sbjct: 119 RSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIE 178
Query: 605 QGVIVEQGTHEDLMKAKGFYHKLVTTGNENK 635
+ + + + + L+ + + + ++ + K
Sbjct: 179 ENKVRQYDSIQKLLNERSLFRQAISPSDRVK 209
Score = 38.7 bits (86), Expect = 0.13
Identities = 27/98 (27%), Positives = 48/98 (48%), Gaps = 5/98 (5%)
Query: 1095 IALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLD 1154
+ L+G +G GKST+L F R + + G I++D S +T+ + R+ GV+ Q+ +
Sbjct: 1 VGLLGRTGSGKSTLLSAFLRLLNTE-GEIQIDGVSWDS-ITLQQWRKAFGVIPQKVFIFS 58
Query: 1155 RSLAENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLP 1192
+ +N+ D + + EI A + S I P
Sbjct: 59 GTFRKNL---DPYEQWSDQEIWKVADEVGLRSVIEQFP 93
>AB012959-1|BAA88711.1| 63|Homo sapiens sister p-glycoprotein
protein.
Length = 63
Score = 88.2 bits (209), Expect = 2e-16
Identities = 43/63 (68%), Positives = 52/63 (82%)
Query: 538 KQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHRLSTIVNA 597
KQRIAIAR+++R+P +LLLDEATSALD SE+ VQ ALD+A GRT I ++HRLSTI NA
Sbjct: 1 KQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNA 60
Query: 598 DRI 600
D I
Sbjct: 61 DII 63
Score = 48.0 bits (109), Expect = 2e-04
Identities = 21/32 (65%), Positives = 27/32 (84%)
Query: 1193 KAVTEALEKAAKGRTCITIAHRLSTVKDADLI 1224
K V AL+KA +GRTCI IAHRLST+++AD+I
Sbjct: 32 KTVQVALDKAREGRTCIVIAHRLSTIQNADII 63
>AL359813-4|CAI23219.1| 172|Homo sapiens ATP-binding cassette,
sub-family C (CFTR/MRP), member 10 protein.
Length = 172
Score = 87.4 bits (207), Expect = 3e-16
Identities = 55/160 (34%), Positives = 83/160 (51%), Gaps = 5/160 (3%)
Query: 392 GDILLEDVEFCY-PSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQA 450
G + +DV Y P P L G + V+PGE + +VG +G GKS++L +L RL +P +
Sbjct: 15 GGVEFQDVVLAYRPGLPNA--LDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSS 72
Query: 451 GSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAY 510
G V + LRS L ++ QEP LF GT+ +N+ R Q + +
Sbjct: 73 GRVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCHL 132
Query: 511 AHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLRE 550
+ S+ G D +GE G SLS GQ+Q + +AR+LL +
Sbjct: 133 SEVITSM--GGLDGELGEGGRSLSLGQRQLLCLARALLTD 170
Score = 66.9 bits (156), Expect = 4e-10
Identities = 36/105 (34%), Positives = 57/105 (54%), Gaps = 4/105 (3%)
Query: 1058 WVASGNFSMRDVEFCYPTRPS-QRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFY 1116
W+ G +DV Y RP L G+ ++ G+ + +VG +G GKS++L + R
Sbjct: 11 WLTQGGVEFQDVVLAY--RPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLL 68
Query: 1117 DPDSGFIELDNRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENI 1161
+P SG + LD D S L + +LR QL ++ QEP L ++ EN+
Sbjct: 69 EPSSGRVLLDGVD-TSQLELAQLRSQLAIIPQEPFLFSGTVRENL 112
>AK094171-1|BAC04300.1| 120|Homo sapiens protein ( Homo sapiens
cDNA FLJ36852 fis, clone ASTRO2014392, moderately
similar to SULFONYLUREA RECEPTOR 1. ).
Length = 120
Score = 86.6 bits (205), Expect = 5e-16
Identities = 40/104 (38%), Positives = 67/104 (64%)
Query: 515 ISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAA 574
+ LP G D V+ E G + S GQ+Q +AR+ +R+ ++L++DEAT+++D +E +Q
Sbjct: 2 VKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKV 61
Query: 575 LDRASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLM 618
+ A RT +T++HR+ TI+ AD +I M +G I+E T E L+
Sbjct: 62 VMTAFADRTVVTIAHRVHTILTADLVIVMKRGNILEYDTPESLL 105
Score = 40.3 bits (90), Expect = 0.043
Identities = 26/91 (28%), Positives = 41/91 (45%), Gaps = 4/91 (4%)
Query: 1159 ENIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAVTEALEK----AAKGRTCITIAHR 1214
EN + G V + + S+ A L+K A RT +TIAHR
Sbjct: 18 ENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHR 77
Query: 1215 LSTVKDADLICVIDKGKIVERGTHAELVSMK 1245
+ T+ ADL+ V+ +G I+E T L++ +
Sbjct: 78 VHTILTADLVIVMKRGNILEYDTPESLLAQE 108
>AL359813-5|CAI23220.1| 157|Homo sapiens ATP-binding cassette,
sub-family C (CFTR/MRP), member 10 protein.
Length = 157
Score = 85.0 bits (201), Expect = 2e-15
Identities = 55/159 (34%), Positives = 87/159 (54%), Gaps = 10/159 (6%)
Query: 398 DVEFCY-PSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXX 456
DV Y P P L G + V+PGE + +VG +G GKS++L +L RL +P +G V
Sbjct: 1 DVVLAYRPGLPNA--LDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLD 58
Query: 457 XXXXXXXXXSWLRSSLGVVGQEPVLFRGTIYDNI---AIGSPEATREEIQR--VAEIAYA 511
+ LRS L ++ QEP LF GT+ +N+ + A + +++ ++E+ +
Sbjct: 59 GVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCHLSEVITS 118
Query: 512 HDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLRE 550
D + L G D +GE G SLS GQ+Q + +AR+LL +
Sbjct: 119 MD--AFLAGGLDGELGEGGRSLSLGQRQLLCLARALLTD 155
Score = 59.7 bits (138), Expect = 7e-08
Identities = 34/95 (35%), Positives = 53/95 (55%), Gaps = 4/95 (4%)
Query: 1068 DVEFCYPTRPS-QRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELD 1126
DV Y RP L G+ ++ G+ + +VG +G GKS++L + R +P SG + LD
Sbjct: 1 DVVLAY--RPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLD 58
Query: 1127 NRDIRSALTIPRLRRQLGVVQQEPVLLDRSLAENI 1161
D S L + +LR QL ++ QEP L ++ EN+
Sbjct: 59 GVD-TSQLELAQLRSQLAIIPQEPFLFSGTVRENL 92
>AC002457-1|AAM49149.1| 234|Homo sapiens unknown protein.
Length = 234
Score = 83.4 bits (197), Expect = 5e-15
Identities = 53/200 (26%), Positives = 96/200 (48%), Gaps = 10/200 (5%)
Query: 18 VSFFQIFRYGNCLELLATALGVVFGMISGAGVCCNLLQIGELSTAFVERTKYHDRLSSYL 77
VS F +FRY N L+ L +G + +I GAG+ +L GE++ F D +S+
Sbjct: 34 VSVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNIT 93
Query: 78 PLTATFGGGKRLVNATHEQNMEALIDDAKAMAIGMFISIGVSLVFCVLSFSLISWSALRQ 137
+ G +N E++M + G+ ++ + + F L+ A RQ
Sbjct: 94 NRSDINDTGF-FMNL--EEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLA-------AGRQ 143
Query: 138 ITRIRTLFLRSVLRQDMSWYDTDSEFNLASKMSENLMSIKEGMGEKLAVVSNLVGTSVIC 197
I +IR F +++RQ++ W+D L +++++++ I EG+G+K+ + + T
Sbjct: 144 IHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTG 203
Query: 198 LCTAFPLGWQLTLACAAVMP 217
F GW+LTL A+ P
Sbjct: 204 FIVGFTRGWKLTLVILAISP 223
Score = 73.7 bits (173), Expect = 4e-12
Identities = 49/177 (27%), Positives = 91/177 (51%), Gaps = 22/177 (12%)
Query: 740 ITVGSIAAFLQGACFPVFALLFGFSSGIFI-----------LDNRDDII---YLADL--- 782
+ VG++AA + GA P+ L+FG + IF + NR DI + +L
Sbjct: 51 MVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITNRSDINDTGFFMNLEED 110
Query: 783 ---YSVLFVVIAAVAGISMCLQSTTFTSAGLKMTTRLRHQYFASLLKQEIGFFDKETNTV 839
Y+ + I A ++ +Q + + A + ++R Q+F ++++QEIG+FD + V
Sbjct: 111 MTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFD--VHDV 168
Query: 840 GAICARLSGDTAEVQGATGLRIGLILQGISSVVVGFLLAISYNWKLTLVATVFLPLM 896
G + RL+ D +++ G +IG+ Q +++ GF++ + WKLTLV P++
Sbjct: 169 GELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVL 225
>U83660-1|AAB71757.1| 162|Homo sapiens multidrug
resistance-associated protein homolog protein.
Length = 162
Score = 83.0 bits (196), Expect = 6e-15
Identities = 38/112 (33%), Positives = 72/112 (64%), Gaps = 1/112 (0%)
Query: 518 LPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDR 577
LP DT + E G++ S GQ+Q + +AR++LR+ +L++DEAT+ +DP ++ +Q +
Sbjct: 8 LPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELIQKKIRE 67
Query: 578 ASVGRTTITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAK-GFYHKLV 628
T +T++HRL+TI+++D+I+ +D G + E L++ K ++K+V
Sbjct: 68 KFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMV 119
Score = 38.3 bits (85), Expect = 0.17
Identities = 26/96 (27%), Positives = 45/96 (46%), Gaps = 7/96 (7%)
Query: 1146 VQQEPVLLDRSLAE---NIAYGDNNRKVTMHEIVAAAKAANIHSFIVSLPKAVTEALEKA 1202
++ P +D LAE N + G I+ + I ++ E ++K
Sbjct: 5 IEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELIQKK 64
Query: 1203 AKGR----TCITIAHRLSTVKDADLICVIDKGKIVE 1234
+ + T +TIAHRL+T+ D+D I V+D G++ E
Sbjct: 65 IREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKE 100
>DQ388144-1|ABD72215.1| 1480|Homo sapiens cystic fibrosis
transmembrane conductance regulator ATP-binding cassette
sub-fa protein.
Length = 1480
Score = 81.8 bits (193), Expect = 1e-14
Identities = 56/220 (25%), Positives = 106/220 (48%), Gaps = 16/220 (7%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
VLK + ++ G+ +A+ GS+G GK+++L ++ +P G + SW+
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIMP 499
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
GTI +NI G + V + + IS + V+GE G
Sbjct: 500 -------------GTIKENIIFGV-SYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGG 545
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVSH 589
+LSGGQ+ RI++AR++ ++ + LLD LD +E+++ ++ + + +T I V+
Sbjct: 546 ITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTS 605
Query: 590 RLSTIVNADRIICMDQGVIVEQGTHEDLMKAK-GFYHKLV 628
++ + AD+I+ + +G GT +L + F KL+
Sbjct: 606 KMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 40.3 bits (90), Expect = 0.043
Identities = 18/48 (37%), Positives = 30/48 (62%)
Query: 1081 VLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNR 1128
VLK I+ K+E G+ +A+ GS+G GK+++L + +P G I+ R
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGR 487
>AC000111-1|AAB46352.1| 996|Homo sapiens unknown protein.
Length = 996
Score = 81.8 bits (193), Expect = 1e-14
Identities = 56/220 (25%), Positives = 106/220 (48%), Gaps = 16/220 (7%)
Query: 411 VLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRS 470
VLK + ++ G+ +A+ GS+G GK+++L ++ +P G + SW+
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIMP 499
Query: 471 SLGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERG 530
GTI +NI G + V + + IS + V+GE G
Sbjct: 500 -------------GTIKENIIFGV-SYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGG 545
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQV-QAALDRASVGRTTITVSH 589
+LSGGQ+ RI++AR++ ++ + LLD LD +E+++ ++ + + +T I V+
Sbjct: 546 ITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTS 605
Query: 590 RLSTIVNADRIICMDQGVIVEQGTHEDLMKAK-GFYHKLV 628
++ + AD+I+ + +G GT +L + F KL+
Sbjct: 606 KMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLM 645
Score = 40.3 bits (90), Expect = 0.043
Identities = 18/48 (37%), Positives = 30/48 (62%)
Query: 1081 VLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNR 1128
VLK I+ K+E G+ +A+ GS+G GK+++L + +P G I+ R
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGR 487
>BC130280-1|AAI30281.1| 1621|Homo sapiens ABCA8 protein protein.
Length = 1621
Score = 79.4 bits (187), Expect = 8e-14
Identities = 74/263 (28%), Positives = 118/263 (44%), Gaps = 21/263 (7%)
Query: 394 ILLEDVEFCYPSRPE-VKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGS 452
I + +V Y +P+ ++ LK + G+ A++G SG GKST+L +L L P GS
Sbjct: 480 IRIRNVTKEYKGKPDKIEALKDLVFDIYEGQITAILGHSGAGKSTLLNILSGLSVPTKGS 539
Query: 453 VXXXXXXXXXXXXSWLRSSL-GVVGQEPVLFRG-TIYDNIAIGS------PEATREEIQR 504
V S L GV Q V F T+ +N+ + + P+ +EIQR
Sbjct: 540 VTIYNNKLSEMADLENLSKLTGVCPQSNVQFDFLTVRENLRLFAKIKGILPQEVDKEIQR 599
Query: 505 VAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALD 564
V + L V+ + +LSGGQK+++ ++L +P + LLDE T+ LD
Sbjct: 600 V--------LLELEMKNIQDVLAQ---NLSGGQKRKLTFGIAILGDPQIFLLDEPTAGLD 648
Query: 565 PHSERQVQAALDRASVGRTTITVSHRLSTI-VNADRIICMDQGVIVEQGTHEDLMKAKGF 623
P S QV L R + + + + ADR + + QG + G+ L K G
Sbjct: 649 PFSRHQVWNLLKERKTDRVILFSTQFMDEADILADRKVFLSQGKLKCAGSSLFLKKKWGI 708
Query: 624 YHKLVTTGNENKEPADIEPLIEE 646
+ L NE +I L+++
Sbjct: 709 GYHLSLQLNEICVEENITSLVKQ 731
Score = 54.4 bits (125), Expect = 2e-06
Identities = 64/251 (25%), Positives = 107/251 (42%), Gaps = 21/251 (8%)
Query: 402 CYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXX 461
C+ R + S V+ GE + L+G +G GKST ++++ P AG V
Sbjct: 1296 CFSKRKNKIATRNVSFCVRKGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLLKGSGGG 1355
Query: 462 XXXXSWLRSSLGVVGQEPVLFRG-TIYDNIAI-GSPEATREEIQRVAEIAYAHDFISLLP 519
LG QE L+ T+ ++ + + + R+ VA I D + L
Sbjct: 1356 DAL-----EFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAEVA-ITRLVDALKLQD 1409
Query: 520 NGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRAS 579
V +LS G K+++ S+L P+V+LLDE ++ +DP ++Q+ A+ RA+
Sbjct: 1410 QLKSPV-----KTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAI-RAT 1463
Query: 580 VGRT----TITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENK 635
T +T + DR+ M G + G+ + L K + K + K
Sbjct: 1464 FRNTERGALLTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHL---KSKFGKDYLLEMKVK 1520
Query: 636 EPADIEPLIEE 646
A +EPL E
Sbjct: 1521 NLAQVEPLHAE 1531
Score = 42.3 bits (95), Expect = 0.011
Identities = 27/98 (27%), Positives = 46/98 (46%), Gaps = 2/98 (2%)
Query: 1066 MRDVEFCYPTRPSQ-RVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIE 1124
+R+V Y +P + LK + + G+ A++G SG GKST+L + P G +
Sbjct: 482 IRNVTKEYKGKPDKIEALKDLVFDIYEGQITAILGHSGAGKSTLLNILSGLSVPTKGSVT 541
Query: 1125 LDNRDIRSALTIPRLRRQLGVVQQEPVLLD-RSLAENI 1161
+ N + + L + GV Q V D ++ EN+
Sbjct: 542 IYNNKLSEMADLENLSKLTGVCPQSNVQFDFLTVRENL 579
>AY028899-1|AAK30024.1| 1624|Homo sapiens ATP-binding cassette A9
protein.
Length = 1624
Score = 76.2 bits (179), Expect = 7e-13
Identities = 67/251 (26%), Positives = 109/251 (43%), Gaps = 20/251 (7%)
Query: 409 VKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVX-XXXXXXXXXXXSW 467
V+ LKG + G+ AL+G SG GK+T+L +L L P +GSV
Sbjct: 497 VEALKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIEN 556
Query: 468 LRSSLGVVGQEPVLFRG-TIYDNIAIGS------PEATREEIQRVAEIAYAHDFISLLPN 520
+ G Q V F T+ +N+ + + P +E+QRV + + +L
Sbjct: 557 ISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEVEKEVQRVVQELEMENIQDIL-- 614
Query: 521 GYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASV 580
+LSGGQ +++ ++L +P VLLLDE T+ LDP S ++ L
Sbjct: 615 ---------AQNLSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLLKEGKS 665
Query: 581 GRTTITVSHRLSTI-VNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENKEPAD 639
R + + + + ADR + + G + G+ L K G + L NE +P
Sbjct: 666 DRVILFSTQFIDEADILADRKVFISNGKLKCAGSSLFLKKKWGIGYHLSLHLNERCDPES 725
Query: 640 IEPLIEEADGD 650
I L+++ D
Sbjct: 726 ITSLVKQHISD 736
Score = 54.4 bits (125), Expect = 2e-06
Identities = 61/250 (24%), Positives = 104/250 (41%), Gaps = 19/250 (7%)
Query: 402 CYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXX 461
C+ R + + S VK GE + L+G +G GKST ++++ P AG V
Sbjct: 1299 CFSKRKKTIATRNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKGSGGG 1358
Query: 462 XXXXSWLRSSLGVVGQEPVLFRG-TIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPN 520
LG QE L+ T+ ++ + + + + I D + L
Sbjct: 1359 EPL-----GFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQ 1413
Query: 521 GYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASV 580
V +LS G K+++ S+L P+V+LLDE ++ +DP ++Q+ + RA+
Sbjct: 1414 LKAPV-----KTLSEGIKRKLRFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVI-RATF 1467
Query: 581 GRT----TITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENKE 636
T +T + DR+ M G + G+ + L K + K + K
Sbjct: 1468 RNTERGALLTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHL---KSKFGKDYLLEMKLKN 1524
Query: 637 PADIEPLIEE 646
A +EPL E
Sbjct: 1525 LAQMEPLHAE 1534
Score = 40.7 bits (91), Expect = 0.032
Identities = 25/95 (26%), Positives = 43/95 (45%), Gaps = 1/95 (1%)
Query: 1082 LKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRR 1141
LKG+ + G+ AL+G SG GK+T+L + P SG + + N + I + +
Sbjct: 500 LKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIENISK 559
Query: 1142 QLGVVQQEPVLLD-RSLAENIAYGDNNRKVTMHEI 1175
G Q V ++ EN+ + + HE+
Sbjct: 560 FTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEV 594
>AK074491-1|BAC11021.1| 483|Homo sapiens protein ( Homo sapiens
cDNA FLJ90010 fis, clone HEMBA1000349, weakly similar to
ATP-BINDING CASSETTE TRANSPORTER 1. ).
Length = 483
Score = 76.2 bits (179), Expect = 7e-13
Identities = 67/251 (26%), Positives = 109/251 (43%), Gaps = 20/251 (7%)
Query: 409 VKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVX-XXXXXXXXXXXSW 467
V+ LKG + G+ AL+G SG GK+T+L +L L P +GSV
Sbjct: 124 VEALKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIEN 183
Query: 468 LRSSLGVVGQEPVLFRG-TIYDNIAIGS------PEATREEIQRVAEIAYAHDFISLLPN 520
+ G Q V F T+ +N+ + + P +E+QRV + + +L
Sbjct: 184 ISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEVEKEVQRVVQELEMENIQDIL-- 241
Query: 521 GYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASV 580
+LSGGQ +++ ++L +P VLLLDE T+ LDP S ++ L
Sbjct: 242 ---------AQNLSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLLKEGKS 292
Query: 581 GRTTITVSHRLSTI-VNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENKEPAD 639
R + + + + ADR + + G + G+ L K G + L NE +P
Sbjct: 293 DRVILFSTQFIDEADILADRKVFISNGKLKCAGSSLFLKKKWGIGYHLSLHLNERCDPES 352
Query: 640 IEPLIEEADGD 650
I L+++ D
Sbjct: 353 ITSLVKQHISD 363
Score = 40.7 bits (91), Expect = 0.032
Identities = 25/95 (26%), Positives = 43/95 (45%), Gaps = 1/95 (1%)
Query: 1082 LKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRR 1141
LKG+ + G+ AL+G SG GK+T+L + P SG + + N + I + +
Sbjct: 127 LKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIENISK 186
Query: 1142 QLGVVQQEPVLLD-RSLAENIAYGDNNRKVTMHEI 1175
G Q V ++ EN+ + + HE+
Sbjct: 187 FTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEV 221
>AK057068-1|BAB71359.1| 856|Homo sapiens protein ( Homo sapiens
cDNA FLJ32506 fis, clone SMINT1000042, weakly similar to
ATP-BINDING CASSETTE, SUB-FAMILY A, MEMBER 3. ).
Length = 856
Score = 76.2 bits (179), Expect = 7e-13
Identities = 67/251 (26%), Positives = 109/251 (43%), Gaps = 20/251 (7%)
Query: 409 VKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVX-XXXXXXXXXXXSW 467
V+ LKG + G+ AL+G SG GK+T+L +L L P +GSV
Sbjct: 497 VEALKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIEN 556
Query: 468 LRSSLGVVGQEPVLFRG-TIYDNIAIGS------PEATREEIQRVAEIAYAHDFISLLPN 520
+ G Q V F T+ +N+ + + P +E+QRV + + +L
Sbjct: 557 ISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEVEKEVQRVVQELEMENIQDIL-- 614
Query: 521 GYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASV 580
+LSGGQ +++ ++L +P VLLLDE T+ LDP S ++ L
Sbjct: 615 ---------AQNLSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLLKEGKS 665
Query: 581 GRTTITVSHRLSTI-VNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENKEPAD 639
R + + + + ADR + + G + G+ L K G + L NE +P
Sbjct: 666 DRVILFSTQFIDEADILADRKVFISNGKLKCAGSSLFLKKKWGIGYHLSLHLNERCDPES 725
Query: 640 IEPLIEEADGD 650
I L+++ D
Sbjct: 726 ITSLVKQHISD 736
Score = 40.7 bits (91), Expect = 0.032
Identities = 25/95 (26%), Positives = 43/95 (45%), Gaps = 1/95 (1%)
Query: 1082 LKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRR 1141
LKG+ + G+ AL+G SG GK+T+L + P SG + + N + I + +
Sbjct: 500 LKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIENISK 559
Query: 1142 QLGVVQQEPVLLD-RSLAENIAYGDNNRKVTMHEI 1175
G Q V ++ EN+ + + HE+
Sbjct: 560 FTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEV 594
>AF423346-1|AAN32752.1| 1624|Homo sapiens ATP-binding cassette
sub-family A member 9 protein.
Length = 1624
Score = 76.2 bits (179), Expect = 7e-13
Identities = 67/251 (26%), Positives = 109/251 (43%), Gaps = 20/251 (7%)
Query: 409 VKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVX-XXXXXXXXXXXSW 467
V+ LKG + G+ AL+G SG GK+T+L +L L P +GSV
Sbjct: 497 VEALKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIEN 556
Query: 468 LRSSLGVVGQEPVLFRG-TIYDNIAIGS------PEATREEIQRVAEIAYAHDFISLLPN 520
+ G Q V F T+ +N+ + + P +E+QRV + + +L
Sbjct: 557 ISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEVEKEVQRVVQELEMENIQDIL-- 614
Query: 521 GYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASV 580
+LSGGQ +++ ++L +P VLLLDE T+ LDP S ++ L
Sbjct: 615 ---------AQNLSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLLKEGKS 665
Query: 581 GRTTITVSHRLSTI-VNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENKEPAD 639
R + + + + ADR + + G + G+ L K G + L NE +P
Sbjct: 666 DRVILFSTQFIDEADILADRKVFISNGKLKCAGSSLFLKKKWGIGYHLSLHLNERCDPES 725
Query: 640 IEPLIEEADGD 650
I L+++ D
Sbjct: 726 ITSLVKQHISD 736
Score = 54.0 bits (124), Expect = 3e-06
Identities = 61/250 (24%), Positives = 104/250 (41%), Gaps = 19/250 (7%)
Query: 402 CYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXX 461
C+ R + + S VK GE + L+G +G GKST ++++ P AG V
Sbjct: 1299 CFSKRKKKIATRNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKGSGGG 1358
Query: 462 XXXXSWLRSSLGVVGQEPVLFRG-TIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPN 520
LG QE L+ T+ ++ + + + + I D + L
Sbjct: 1359 EPL-----GFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQ 1413
Query: 521 GYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASV 580
V +LS G K+++ S+L P+V+LLDE ++ +DP ++Q+ + RA+
Sbjct: 1414 LKAPV-----KTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVI-RATF 1467
Query: 581 GRT----TITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENKE 636
T +T + DR+ M G + G+ + L K + K + K
Sbjct: 1468 RNTERGALLTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHL---KSKFGKDYLLEMKLKN 1524
Query: 637 PADIEPLIEE 646
A +EPL E
Sbjct: 1525 LAQMEPLHAE 1534
Score = 40.7 bits (91), Expect = 0.032
Identities = 25/95 (26%), Positives = 43/95 (45%), Gaps = 1/95 (1%)
Query: 1082 LKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRR 1141
LKG+ + G+ AL+G SG GK+T+L + P SG + + N + I + +
Sbjct: 500 LKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIENISK 559
Query: 1142 QLGVVQQEPVLLD-RSLAENIAYGDNNRKVTMHEI 1175
G Q V ++ EN+ + + HE+
Sbjct: 560 FTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEV 594
Score = 32.7 bits (71), Expect = 8.6
Identities = 14/54 (25%), Positives = 28/54 (51%)
Query: 1072 CYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIEL 1125
C+ R + + + ++ G+ I L+G +G GKST +++ P +G + L
Sbjct: 1299 CFSKRKKKIATRNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVIL 1352
>AF423307-1|AAN32751.1| 1624|Homo sapiens ATP-binding cassette
sub-family A member 9 protein.
Length = 1624
Score = 76.2 bits (179), Expect = 7e-13
Identities = 67/251 (26%), Positives = 109/251 (43%), Gaps = 20/251 (7%)
Query: 409 VKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVX-XXXXXXXXXXXSW 467
V+ LKG + G+ AL+G SG GK+T+L +L L P +GSV
Sbjct: 497 VEALKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIEN 556
Query: 468 LRSSLGVVGQEPVLFRG-TIYDNIAIGS------PEATREEIQRVAEIAYAHDFISLLPN 520
+ G Q V F T+ +N+ + + P +E+QRV + + +L
Sbjct: 557 ISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEVEKEVQRVVQELEMENIQDIL-- 614
Query: 521 GYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASV 580
+LSGGQ +++ ++L +P VLLLDE T+ LDP S ++ L
Sbjct: 615 ---------AQNLSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLLKEGKS 665
Query: 581 GRTTITVSHRLSTI-VNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENKEPAD 639
R + + + + ADR + + G + G+ L K G + L NE +P
Sbjct: 666 DRVILFSTQFIDEADILADRKVFISNGKLKCAGSSLFLKKKWGIGYHLSLHLNERCDPES 725
Query: 640 IEPLIEEADGD 650
I L+++ D
Sbjct: 726 ITSLVKQHISD 736
Score = 54.0 bits (124), Expect = 3e-06
Identities = 61/250 (24%), Positives = 104/250 (41%), Gaps = 19/250 (7%)
Query: 402 CYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXX 461
C+ R + + S VK GE + L+G +G GKST ++++ P AG V
Sbjct: 1299 CFSKRKKKIATRNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKGSGGG 1358
Query: 462 XXXXSWLRSSLGVVGQEPVLFRG-TIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPN 520
LG QE L+ T+ ++ + + + + I D + L
Sbjct: 1359 EPL-----GFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQ 1413
Query: 521 GYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASV 580
V +LS G K+++ S+L P+V+LLDE ++ +DP ++Q+ + RA+
Sbjct: 1414 LKAPV-----KTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVI-RATF 1467
Query: 581 GRT----TITVSHRLSTIVNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENKE 636
T +T + DR+ M G + G+ + L K + K + K
Sbjct: 1468 RNTERGALLTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHL---KSKFGKDYLLEMKLKN 1524
Query: 637 PADIEPLIEE 646
A +EPL E
Sbjct: 1525 LAQMEPLHAE 1534
Score = 40.7 bits (91), Expect = 0.032
Identities = 25/95 (26%), Positives = 43/95 (45%), Gaps = 1/95 (1%)
Query: 1082 LKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRR 1141
LKG+ + G+ AL+G SG GK+T+L + P SG + + N + I + +
Sbjct: 500 LKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIENISK 559
Query: 1142 QLGVVQQEPVLLD-RSLAENIAYGDNNRKVTMHEI 1175
G Q V ++ EN+ + + HE+
Sbjct: 560 FTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEV 594
Score = 32.7 bits (71), Expect = 8.6
Identities = 14/54 (25%), Positives = 28/54 (51%)
Query: 1072 CYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIEL 1125
C+ R + + + ++ G+ I L+G +G GKST +++ P +G + L
Sbjct: 1299 CFSKRKKKIATRNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVIL 1352
>X97187-1|CAA65825.1| 1704|Homo sapiens ABC-C transporter protein.
Length = 1704
Score = 75.8 bits (178), Expect = 9e-13
Identities = 57/235 (24%), Positives = 105/235 (44%), Gaps = 8/235 (3%)
Query: 412 LKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSS 471
++ ++++ G+ L+G +G GK+T L +L L+ P +G +R S
Sbjct: 549 VRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMVQ-IRKS 607
Query: 472 LGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPN-GYDTVIGERG 530
LG+ Q +LF DN+ + +++ ++ + +L G + R
Sbjct: 608 LGLCPQHDILF-----DNLTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGLEDKWNSRS 662
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHR 590
LSGG +++++I +L+ VL+LDE TS +D S R + L R RT + +H
Sbjct: 663 RFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIVLTTHF 722
Query: 591 LSTI-VNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENKEPADIEPLI 644
+ + DRI M +G + G+ L + G + + + P DI L+
Sbjct: 723 MDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTLVKEPHCNPEDISQLV 777
Score = 52.4 bits (120), Expect = 1e-05
Identities = 54/237 (22%), Positives = 101/237 (42%), Gaps = 9/237 (3%)
Query: 394 ILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSV 453
++++++ Y R + + S+ V+ GEC L+G +G GK+T ++L +G
Sbjct: 1381 LIIKELSKVYEQRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDA 1440
Query: 454 XXXXXXXXXXXXSWLRSSLGVVGQ-EPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAH 512
+R +G Q + +L T + + + + E A +
Sbjct: 1441 FVGGHRISSDVGK-VRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTL 1499
Query: 513 DFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQ 572
+ L P+ V + SGG K++++ +L+ EPAV+ LDE ++ +DP + R +
Sbjct: 1500 RGLLLEPHANKLV-----RTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLW 1554
Query: 573 AALDRA-SVGRTTITVSHRLSTI-VNADRIICMDQGVIVEQGTHEDLMKAKGFYHKL 627
+ RA G+ I SH + R+ M QG G+ + L G + L
Sbjct: 1555 DTVARARESGKAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSL 1611
Score = 42.3 bits (95), Expect = 0.011
Identities = 46/205 (22%), Positives = 87/205 (42%), Gaps = 13/205 (6%)
Query: 964 RWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVY- 1022
+WR L+ + V F C V G +L+ + Y LV EA+ G + + Q +
Sbjct: 433 QWRDLLSPVNVDDDF---CFGQVLGMLLL--DSVLYGLVTWYMEAVFPGQFGVPQPWYFF 487
Query: 1023 -APSLNTAK--ACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQ 1079
PS K A + + + N + +D VA F + +
Sbjct: 488 IMPSYWCGKPRAVAGKEEEDSDPEKALRNEYFEAEPEDLVAGIKIKHLSKVFRVGNK-DR 546
Query: 1080 RVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRL 1139
++ ++L + G+ L+G +G GK+T L + + P SG + +I + ++
Sbjct: 547 AAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMV--QI 604
Query: 1140 RRQLGVVQQEPVLLDR-SLAENIAY 1163
R+ LG+ Q +L D ++AE++ +
Sbjct: 605 RKSLGLCPQHDILFDNLTVAEHLYF 629
>U78735-1|AAC50967.1| 1704|Homo sapiens ABC3 protein.
Length = 1704
Score = 75.8 bits (178), Expect = 9e-13
Identities = 57/235 (24%), Positives = 105/235 (44%), Gaps = 8/235 (3%)
Query: 412 LKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSS 471
++ ++++ G+ L+G +G GK+T L +L L+ P +G +R S
Sbjct: 549 VRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMVQ-IRKS 607
Query: 472 LGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPN-GYDTVIGERG 530
LG+ Q +LF DN+ + +++ ++ + +L G + R
Sbjct: 608 LGLCPQHDILF-----DNLTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGLEDKWNSRS 662
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHR 590
LSGG +++++I +L+ VL+LDE TS +D S R + L R RT + +H
Sbjct: 663 RFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIVLTTHF 722
Query: 591 LSTI-VNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENKEPADIEPLI 644
+ + DRI M +G + G+ L + G + + + P DI L+
Sbjct: 723 MDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTLVKEPHCNPEDISQLV 777
Score = 52.4 bits (120), Expect = 1e-05
Identities = 54/237 (22%), Positives = 101/237 (42%), Gaps = 9/237 (3%)
Query: 394 ILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSV 453
++++++ Y R + + S+ V+ GEC L+G +G GK+T ++L +G
Sbjct: 1381 LIIKELSKVYEQRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDA 1440
Query: 454 XXXXXXXXXXXXSWLRSSLGVVGQ-EPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAH 512
+R +G Q + +L T + + + + E A +
Sbjct: 1441 FVGGHRISSDVGK-VRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTL 1499
Query: 513 DFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQ 572
+ L P+ V + SGG K++++ +L+ EPAV+ LDE ++ +DP + R +
Sbjct: 1500 RGLLLEPHANKLV-----RTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLW 1554
Query: 573 AALDRA-SVGRTTITVSHRLSTI-VNADRIICMDQGVIVEQGTHEDLMKAKGFYHKL 627
+ RA G+ I SH + R+ M QG G+ + L G + L
Sbjct: 1555 DTVARARESGKAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSL 1611
Score = 42.3 bits (95), Expect = 0.011
Identities = 46/205 (22%), Positives = 87/205 (42%), Gaps = 13/205 (6%)
Query: 964 RWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVY- 1022
+WR L+ + V F C V G +L+ + Y LV EA+ G + + Q +
Sbjct: 433 QWRDLLSPVNVDDDF---CFGQVLGMLLL--DSVLYGLVTWYMEAVFPGQFGVPQPWYFF 487
Query: 1023 -APSLNTAK--ACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQ 1079
PS K A + + + N + +D VA F + +
Sbjct: 488 IMPSYWCGKPRAVAGKEEEDSDPEKALRNEYFEAEPEDLVAGIKIKHLSKVFRVGNK-DR 546
Query: 1080 RVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRL 1139
++ ++L + G+ L+G +G GK+T L + + P SG + +I + ++
Sbjct: 547 AAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMV--QI 604
Query: 1140 RRQLGVVQQEPVLLDR-SLAENIAY 1163
R+ LG+ Q +L D ++AE++ +
Sbjct: 605 RKSLGLCPQHDILFDNLTVAEHLYF 629
>DQ073080-1|AAY57325.1| 1704|Homo sapiens ATP-binding cassette,
sub-family A (ABC1), member 3 protein.
Length = 1704
Score = 75.8 bits (178), Expect = 9e-13
Identities = 57/235 (24%), Positives = 105/235 (44%), Gaps = 8/235 (3%)
Query: 412 LKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSS 471
++ ++++ G+ L+G +G GK+T L +L L+ P +G +R S
Sbjct: 549 VRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMVQ-IRKS 607
Query: 472 LGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPN-GYDTVIGERG 530
LG+ Q +LF DN+ + +++ ++ + +L G + R
Sbjct: 608 LGLCPQHDILF-----DNLTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGLEDKWNSRS 662
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHR 590
LSGG +++++I +L+ VL+LDE TS +D S R + L R RT + +H
Sbjct: 663 RFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIVLTTHF 722
Query: 591 LSTI-VNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENKEPADIEPLI 644
+ + DRI M +G + G+ L + G + + + P DI L+
Sbjct: 723 MDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTLVKEPHCNPEDISQLV 777
Score = 52.4 bits (120), Expect = 1e-05
Identities = 54/237 (22%), Positives = 101/237 (42%), Gaps = 9/237 (3%)
Query: 394 ILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSV 453
++++++ Y R + + S+ V+ GEC L+G +G GK+T ++L +G
Sbjct: 1381 LIIKELSKVYEQRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDA 1440
Query: 454 XXXXXXXXXXXXSWLRSSLGVVGQ-EPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAH 512
+R +G Q + +L T + + + + E A +
Sbjct: 1441 FVGGHRISSDVGK-VRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTL 1499
Query: 513 DFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQ 572
+ L P+ V + SGG K++++ +L+ EPAV+ LDE ++ +DP + R +
Sbjct: 1500 RGLLLEPHANKLV-----RTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLW 1554
Query: 573 AALDRA-SVGRTTITVSHRLSTI-VNADRIICMDQGVIVEQGTHEDLMKAKGFYHKL 627
+ RA G+ I SH + R+ M QG G+ + L G + L
Sbjct: 1555 DTVARARESGKAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSL 1611
Score = 42.3 bits (95), Expect = 0.011
Identities = 46/205 (22%), Positives = 87/205 (42%), Gaps = 13/205 (6%)
Query: 964 RWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVY- 1022
+WR L+ + V F C V G +L+ + Y LV EA+ G + + Q +
Sbjct: 433 QWRDLLSPVNVDDDF---CFGQVLGMLLL--DSVLYGLVTWYMEAVFPGQFGVPQPWYFF 487
Query: 1023 -APSLNTAK--ACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQ 1079
PS K A + + + N + +D VA F + +
Sbjct: 488 IMPSYWCGKPRAVAGKEEEDSDPEKALRNEYFEAEPEDLVAGIKIKHLSKVFRVGNK-DR 546
Query: 1080 RVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRL 1139
++ ++L + G+ L+G +G GK+T L + + P SG + +I + ++
Sbjct: 547 AAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMV--QI 604
Query: 1140 RRQLGVVQQEPVLLDR-SLAENIAY 1163
R+ LG+ Q +L D ++AE++ +
Sbjct: 605 RKSLGLCPQHDILFDNLTVAEHLYF 629
>AB210044-1|BAE06126.1| 1708|Homo sapiens ABCA3 variant protein
protein.
Length = 1708
Score = 75.8 bits (178), Expect = 9e-13
Identities = 57/235 (24%), Positives = 105/235 (44%), Gaps = 8/235 (3%)
Query: 412 LKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSS 471
++ ++++ G+ L+G +G GK+T L +L L+ P +G +R S
Sbjct: 553 VRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMVQ-IRKS 611
Query: 472 LGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPN-GYDTVIGERG 530
LG+ Q +LF DN+ + +++ ++ + +L G + R
Sbjct: 612 LGLCPQHDILF-----DNLTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGLEDKWNSRS 666
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHR 590
LSGG +++++I +L+ VL+LDE TS +D S R + L R RT + +H
Sbjct: 667 RFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIVLTTHF 726
Query: 591 LSTI-VNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENKEPADIEPLI 644
+ + DRI M +G + G+ L + G + + + P DI L+
Sbjct: 727 MDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTLVKEPHCNPEDISQLV 781
Score = 52.4 bits (120), Expect = 1e-05
Identities = 54/237 (22%), Positives = 101/237 (42%), Gaps = 9/237 (3%)
Query: 394 ILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSV 453
++++++ Y R + + S+ V+ GEC L+G +G GK+T ++L +G
Sbjct: 1385 LIIKELSKVYEQRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDA 1444
Query: 454 XXXXXXXXXXXXSWLRSSLGVVGQ-EPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAH 512
+R +G Q + +L T + + + + E A +
Sbjct: 1445 FVGGHRISSDVGK-VRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTL 1503
Query: 513 DFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQ 572
+ L P+ V + SGG K++++ +L+ EPAV+ LDE ++ +DP + R +
Sbjct: 1504 RGLLLEPHANKLV-----RTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLW 1558
Query: 573 AALDRA-SVGRTTITVSHRLSTI-VNADRIICMDQGVIVEQGTHEDLMKAKGFYHKL 627
+ RA G+ I SH + R+ M QG G+ + L G + L
Sbjct: 1559 DTVARARESGKAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSL 1615
Score = 42.3 bits (95), Expect = 0.011
Identities = 46/205 (22%), Positives = 87/205 (42%), Gaps = 13/205 (6%)
Query: 964 RWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVY- 1022
+WR L+ + V F C V G +L+ + Y LV EA+ G + + Q +
Sbjct: 437 QWRDLLSPVNVDDDF---CFGQVLGMLLL--DSVLYGLVTWYMEAVFPGQFGVPQPWYFF 491
Query: 1023 -APSLNTAK--ACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQ 1079
PS K A + + + N + +D VA F + +
Sbjct: 492 IMPSYWCGKPRAVAGKEEEDSDPEKALRNEYFEAEPEDLVAGIKIKHLSKVFRVGNK-DR 550
Query: 1080 RVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRL 1139
++ ++L + G+ L+G +G GK+T L + + P SG + +I + ++
Sbjct: 551 AAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMV--QI 608
Query: 1140 RRQLGVVQQEPVLLDR-SLAENIAY 1163
R+ LG+ Q +L D ++AE++ +
Sbjct: 609 RKSLGLCPQHDILFDNLTVAEHLYF 633
>AB070929-1|BAB86781.1| 1704|Homo sapiens lamellar body membrane
specific ATP-binding cassette protein protein.
Length = 1704
Score = 75.8 bits (178), Expect = 9e-13
Identities = 57/235 (24%), Positives = 105/235 (44%), Gaps = 8/235 (3%)
Query: 412 LKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSS 471
++ ++++ G+ L+G +G GK+T L +L L+ P +G +R S
Sbjct: 549 VRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMVQ-IRKS 607
Query: 472 LGVVGQEPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPN-GYDTVIGERG 530
LG+ Q +LF DN+ + +++ ++ + +L G + R
Sbjct: 608 LGLCPQHDILF-----DNLTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGLEDKWNSRS 662
Query: 531 ASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDRASVGRTTITVSHR 590
LSGG +++++I +L+ VL+LDE TS +D S R + L R RT + +H
Sbjct: 663 RFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIVLTTHF 722
Query: 591 LSTI-VNADRIICMDQGVIVEQGTHEDLMKAKGFYHKLVTTGNENKEPADIEPLI 644
+ + DRI M +G + G+ L + G + + + P DI L+
Sbjct: 723 MDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTLVKEPHCNPEDISQLV 777
Score = 52.4 bits (120), Expect = 1e-05
Identities = 54/237 (22%), Positives = 101/237 (42%), Gaps = 9/237 (3%)
Query: 394 ILLEDVEFCYPSRPEVKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSV 453
++++++ Y R + + S+ V+ GEC L+G +G GK+T ++L +G
Sbjct: 1381 LIIKELSKVYEQRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDA 1440
Query: 454 XXXXXXXXXXXXSWLRSSLGVVGQ-EPVLFRGTIYDNIAIGSPEATREEIQRVAEIAYAH 512
+R +G Q + +L T + + + + E A +
Sbjct: 1441 FVGGHRISSDVGK-VRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTL 1499
Query: 513 DFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQ 572
+ L P+ V + SGG K++++ +L+ EPAV+ LDE ++ +DP + R +
Sbjct: 1500 RGLLLEPHANKLV-----RTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLW 1554
Query: 573 AALDRA-SVGRTTITVSHRLSTI-VNADRIICMDQGVIVEQGTHEDLMKAKGFYHKL 627
+ RA G+ I SH + R+ M QG G+ + L G + L
Sbjct: 1555 DTVARARESGKAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSL 1611
Score = 42.3 bits (95), Expect = 0.011
Identities = 46/205 (22%), Positives = 87/205 (42%), Gaps = 13/205 (6%)
Query: 964 RWRGLVYGLGVYIPFMAYCSATVYGAVLVAYGEMEYKLVLLVNEAIMYGAYMLGQSLVY- 1022
+WR L+ + V F C V G +L+ + Y LV EA+ G + + Q +
Sbjct: 433 QWRDLLSPVNVDDDF---CFGQVLGMLLL--DSVLYGLVTWYMEAVFPGQFGVPQPWYFF 487
Query: 1023 -APSLNTAK--ACGARILSIIQRQPKIHNAVGVKDKKDWVASGNFSMRDVEFCYPTRPSQ 1079
PS K A + + + N + +D VA F + +
Sbjct: 488 IMPSYWCGKPRAVAGKEEEDSDPEKALRNEYFEAEPEDLVAGIKIKHLSKVFRVGNK-DR 546
Query: 1080 RVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRL 1139
++ ++L + G+ L+G +G GK+T L + + P SG + +I + ++
Sbjct: 547 AAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMV--QI 604
Query: 1140 RRQLGVVQQEPVLLDR-SLAENIAY 1163
R+ LG+ Q +L D ++AE++ +
Sbjct: 605 RKSLGLCPQHDILFDNLTVAEHLYF 629
>BX640746-1|CAE45856.1| 431|Homo sapiens hypothetical protein
protein.
Length = 431
Score = 74.9 bits (176), Expect = 2e-12
Identities = 62/238 (26%), Positives = 107/238 (44%), Gaps = 9/238 (3%)
Query: 394 ILLEDVEFCYPSRPE-VKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGS 452
I + ++ Y + E V+ L+ S + G+ AL+G SG GKST++ +L L P G
Sbjct: 149 IRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGF 208
Query: 453 VXXXXXXXXXXXXSW-LRSSLGVVGQEPVLFRG-TIYDNIAIGSPEATREEIQRVAEIAY 510
+ R +G+ Q + F T+ +N++I + + E+
Sbjct: 209 ASIYGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQK 268
Query: 511 AHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQ 570
LL T+ + LSGGQK+++++ ++L P +LLLDE T+ +DP S
Sbjct: 269 V-----LLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHI 323
Query: 571 VQAALDRASVGRTTITVSHRLSTI-VNADRIICMDQGVIVEQGTHEDLMKAKGFYHKL 627
V L R T+ +H + + ADR + QG++ G+ L G ++L
Sbjct: 324 VWNLLKYRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRL 381
Score = 37.5 bits (83), Expect = 0.30
Identities = 20/82 (24%), Positives = 39/82 (47%), Gaps = 1/82 (1%)
Query: 1082 LKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRR 1141
L+ + + G+ AL+G SG GKST++ + P GF + + + R+
Sbjct: 168 LRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFEARK 227
Query: 1142 QLGVVQQEPVLLD-RSLAENIA 1162
+G+ Q + D ++ EN++
Sbjct: 228 MIGICPQLDIHFDVLTVEENLS 249
>AY028897-1|AAK30022.1| 1642|Homo sapiens ATP-binding cassette A5
protein.
Length = 1642
Score = 74.9 bits (176), Expect = 2e-12
Identities = 62/238 (26%), Positives = 107/238 (44%), Gaps = 9/238 (3%)
Query: 394 ILLEDVEFCYPSRPE-VKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGS 452
I + ++ Y + E V+ L+ S + G+ AL+G SG GKST++ +L L P G
Sbjct: 478 IRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGF 537
Query: 453 VXXXXXXXXXXXXSW-LRSSLGVVGQEPVLFRG-TIYDNIAIGSPEATREEIQRVAEIAY 510
+ R +G+ Q + F T+ +N++I + + E+
Sbjct: 538 ASIYGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQK 597
Query: 511 AHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQ 570
LL T+ + LSGGQK+++++ ++L P +LLLDE T+ +DP S
Sbjct: 598 V-----LLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHI 652
Query: 571 VQAALDRASVGRTTITVSHRLSTI-VNADRIICMDQGVIVEQGTHEDLMKAKGFYHKL 627
V L R T+ +H + + ADR + QG++ G+ L G ++L
Sbjct: 653 VWNLLKYRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRL 710
Score = 54.4 bits (125), Expect = 2e-06
Identities = 61/232 (26%), Positives = 101/232 (43%), Gaps = 22/232 (9%)
Query: 405 SRPEVKVL-KGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXX 463
SR KV K S VK GE + L+G +G GKST++ +L +P +G V
Sbjct: 1308 SRKVKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETS 1367
Query: 464 XXSWLRSSLGVVGQ-EPVLFRGTIYDNIAI-----GSPEATREEIQRVAEIAYAHDFISL 517
+G Q P+ T+ ++ I G + +E+ ++ I +A D
Sbjct: 1368 EDDDSLKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEV--ISRITHALDLKEH 1425
Query: 518 LPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDR 577
L TV L G K+++ A S+L P + LLDE ++ +DP +++ + A+
Sbjct: 1426 LQK---TV-----KKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRT 1477
Query: 578 A--SVGRTTITVSHRLSTI-VNADRIICMDQGVIVEQGTHEDLMK--AKGFY 624
A + R I +H + DR+ M G + GT + L KG++
Sbjct: 1478 AFKNRKRAAILTTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYF 1529
Score = 37.5 bits (83), Expect = 0.30
Identities = 20/82 (24%), Positives = 39/82 (47%), Gaps = 1/82 (1%)
Query: 1082 LKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRR 1141
L+ + + G+ AL+G SG GKST++ + P GF + + + R+
Sbjct: 497 LRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFEARK 556
Query: 1142 QLGVVQQEPVLLD-RSLAENIA 1162
+G+ Q + D ++ EN++
Sbjct: 557 MIGICPQLDIHFDVLTVEENLS 578
Score = 33.1 bits (72), Expect = 6.5
Identities = 24/96 (25%), Positives = 44/96 (45%), Gaps = 1/96 (1%)
Query: 1070 EFCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRD 1129
+F + + K I ++ G+ + L+G +G GKSTI+ + +P SG + L +
Sbjct: 1304 DFLLSRKVKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYS 1363
Query: 1130 IRSALTIPRLRRQLGVVQQEPVLLDRSLAENI-AYG 1164
++ L+ Q P+ D +L E+ YG
Sbjct: 1364 SETSEDDDSLKCMGYCPQINPLWPDTTLQEHFEIYG 1399
>AJ275973-1|CAB93535.3| 1642|Homo sapiens ATP-binding cassette
protein protein.
Length = 1642
Score = 74.9 bits (176), Expect = 2e-12
Identities = 62/238 (26%), Positives = 107/238 (44%), Gaps = 9/238 (3%)
Query: 394 ILLEDVEFCYPSRPE-VKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGS 452
I + ++ Y + E V+ L+ S + G+ AL+G SG GKST++ +L L P G
Sbjct: 478 IRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGF 537
Query: 453 VXXXXXXXXXXXXSW-LRSSLGVVGQEPVLFRG-TIYDNIAIGSPEATREEIQRVAEIAY 510
+ R +G+ Q + F T+ +N++I + + E+
Sbjct: 538 ASIYGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQK 597
Query: 511 AHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQ 570
LL T+ + LSGGQK+++++ ++L P +LLLDE T+ +DP S
Sbjct: 598 V-----LLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHI 652
Query: 571 VQAALDRASVGRTTITVSHRLSTI-VNADRIICMDQGVIVEQGTHEDLMKAKGFYHKL 627
V L R T+ +H + + ADR + QG++ G+ L G ++L
Sbjct: 653 VWNLLKYRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRL 710
Score = 54.0 bits (124), Expect = 3e-06
Identities = 60/232 (25%), Positives = 101/232 (43%), Gaps = 22/232 (9%)
Query: 405 SRPEVKVL-KGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXX 463
SR KV K S VK GE + L+G +G GKST++ +L +P +G +
Sbjct: 1308 SRKVKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQIFLGDYSSESS 1367
Query: 464 XXSWLRSSLGVVGQ-EPVLFRGTIYDNIAI-----GSPEATREEIQRVAEIAYAHDFISL 517
+G Q P+ T+ ++ I G + +E+ ++ I +A D
Sbjct: 1368 EDDDSLKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSASDMKEV--ISRITHALDLKEH 1425
Query: 518 LPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQVQAALDR 577
L TV L G K+++ A S+L P + LLDE ++ +DP +++ + A+
Sbjct: 1426 LQK---TV-----KKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRT 1477
Query: 578 A--SVGRTTITVSHRLSTI-VNADRIICMDQGVIVEQGTHEDLMK--AKGFY 624
A + R I +H + DR+ M G + GT + L KG++
Sbjct: 1478 AFKNRKRAAILTTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYF 1529
Score = 37.5 bits (83), Expect = 0.30
Identities = 20/82 (24%), Positives = 39/82 (47%), Gaps = 1/82 (1%)
Query: 1082 LKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRR 1141
L+ + + G+ AL+G SG GKST++ + P GF + + + R+
Sbjct: 497 LRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFEARK 556
Query: 1142 QLGVVQQEPVLLD-RSLAENIA 1162
+G+ Q + D ++ EN++
Sbjct: 557 MIGICPQLDIHFDVLTVEENLS 578
Score = 34.7 bits (76), Expect = 2.1
Identities = 26/96 (27%), Positives = 44/96 (45%), Gaps = 1/96 (1%)
Query: 1070 EFCYPTRPSQRVLKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRD 1129
+F + + K I ++ G+ + L+G +G GKSTI+ + +P SG I L +
Sbjct: 1304 DFLLSRKVKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQIFLGDYS 1363
Query: 1130 IRSALTIPRLRRQLGVVQQEPVLLDRSLAENI-AYG 1164
S+ L+ Q P+ D +L E+ YG
Sbjct: 1364 SESSEDDDSLKCMGYCPQINPLWPDTTLQEHFEIYG 1399
>AJ512612-1|CAD54757.1| 925|Homo sapiens ABCA5 transporter protein.
Length = 925
Score = 74.1 bits (174), Expect = 3e-12
Identities = 62/238 (26%), Positives = 106/238 (44%), Gaps = 9/238 (3%)
Query: 394 ILLEDVEFCYPSRPE-VKVLKGFSIHVKPGECVALVGSSGCGKSTVLQLLQRLYDPQAGS 452
I + + Y + E V+ L+ S + G+ AL+G SG GKST++ +L L P G
Sbjct: 478 IRISGIRKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGF 537
Query: 453 VXXXXXXXXXXXXSW-LRSSLGVVGQEPVLFRG-TIYDNIAIGSPEATREEIQRVAEIAY 510
+ R +G+ Q + F T+ +N++I + + E+
Sbjct: 538 ASIYGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQK 597
Query: 511 AHDFISLLPNGYDTVIGERGASLSGGQKQRIAIARSLLREPAVLLLDEATSALDPHSERQ 570
LL T+ + LSGGQK+++++ ++L P +LLLDE T+ +DP S
Sbjct: 598 V-----LLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHI 652
Query: 571 VQAALDRASVGRTTITVSHRLSTI-VNADRIICMDQGVIVEQGTHEDLMKAKGFYHKL 627
V L R T+ +H + + ADR + QG++ G+ L G ++L
Sbjct: 653 VWNLLKYRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRL 710
Score = 37.5 bits (83), Expect = 0.30
Identities = 20/82 (24%), Positives = 39/82 (47%), Gaps = 1/82 (1%)
Query: 1082 LKGIDLKMEAGKTIALVGSSGCGKSTILQLFQRFYDPDSGFIELDNRDIRSALTIPRLRR 1141
L+ + + G+ AL+G SG GKST++ + P GF + + + R+
Sbjct: 497 LRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFEARK 556
Query: 1142 QLGVVQQEPVLLD-RSLAENIA 1162
+G+ Q + D ++ EN++
Sbjct: 557 MIGICPQLDIHFDVLTVEENLS 578
>X91249-1|CAA62631.1| 674|Homo sapiens white protein.
Length = 674
Score = 72.9 bits (171), Expect = 7e-12
Identities = 68/253 (26%), Positives = 115/253 (45%), Gaps = 14/253 (5%)
Query: 369 HLIEREPKIDSLQQKGLTPRRVVGDILLEDVEFCYPSRPEVK------VLKGFSIHVKPG 422
HL + + + Q+ PRR +I D+ + P P + +LKG S G
Sbjct: 48 HLKKVDNNLTEAQRFSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSG 107
Query: 423 ECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLF 482
E VA++G SG GKST++ +L Y + + S ++ + +L
Sbjct: 108 ELVAIMGPSGAGKSTLMNILAG-YRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLP 166
Query: 483 RGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIA 542
T+ + + + + +E+ + E+ + ++ L G + R SLSGGQ++R+A
Sbjct: 167 HLTVQEAMMVSAHLKLQEKDEGRREMV--KEILTAL--GLLSCANTRTGSLSGGQRKRLA 222
Query: 543 IARSLLREPAVLLLDEATSALDPHSERQVQAAL-DRASVGRTTITVSHRLSTIVNA--DR 599
IA L+ P V+ DE TS LD S QV + + A GR+ I H+ S + D+
Sbjct: 223 IALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQ 282
Query: 600 IICMDQGVIVEQG 612
+ + QG V +G
Sbjct: 283 LYVLSQGQCVYRG 295
Score = 40.3 bits (90), Expect = 0.043
Identities = 21/58 (36%), Positives = 33/58 (56%), Gaps = 6/58 (10%)
Query: 1060 ASGNFSMRDVEFCYPTRPSQR------VLKGIDLKMEAGKTIALVGSSGCGKSTILQL 1111
A+ N RD+ + P P R +LKGI K +G+ +A++G SG GKST++ +
Sbjct: 69 AAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNI 126
>U34919-1|AAC51098.1| 638|Homo sapiens white homolog protein.
Length = 638
Score = 72.9 bits (171), Expect = 7e-12
Identities = 68/253 (26%), Positives = 115/253 (45%), Gaps = 14/253 (5%)
Query: 369 HLIEREPKIDSLQQKGLTPRRVVGDILLEDVEFCYPSRPEVK------VLKGFSIHVKPG 422
HL + + + Q+ PRR +I D+ + P P + +LKG S G
Sbjct: 12 HLKKVDNNLTEAQRFSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSG 71
Query: 423 ECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLF 482
E VA++G SG GKST++ +L Y + + S ++ + +L
Sbjct: 72 ELVAIMGPSGAGKSTLMNILAG-YRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLP 130
Query: 483 RGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIA 542
T+ + + + + +E+ + E+ + ++ L G + R SLSGGQ++R+A
Sbjct: 131 HLTVQEAMMVSAHLKLQEKDEGRREMV--KEILTAL--GLLSCANTRTGSLSGGQRKRLA 186
Query: 543 IARSLLREPAVLLLDEATSALDPHSERQVQAAL-DRASVGRTTITVSHRLSTIVNA--DR 599
IA L+ P V+ DE TS LD S QV + + A GR+ I H+ S + D+
Sbjct: 187 IALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQ 246
Query: 600 IICMDQGVIVEQG 612
+ + QG V +G
Sbjct: 247 LYVLSQGQCVYRG 259
Score = 40.3 bits (90), Expect = 0.043
Identities = 21/58 (36%), Positives = 33/58 (56%), Gaps = 6/58 (10%)
Query: 1060 ASGNFSMRDVEFCYPTRPSQR------VLKGIDLKMEAGKTIALVGSSGCGKSTILQL 1111
A+ N RD+ + P P R +LKGI K +G+ +A++G SG GKST++ +
Sbjct: 33 AAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNI 90
>BC029158-1|AAH29158.2| 666|Homo sapiens ATP-binding cassette,
sub-family G (WHITE), member 1 protein.
Length = 666
Score = 72.9 bits (171), Expect = 7e-12
Identities = 68/253 (26%), Positives = 115/253 (45%), Gaps = 14/253 (5%)
Query: 369 HLIEREPKIDSLQQKGLTPRRVVGDILLEDVEFCYPSRPEVK------VLKGFSIHVKPG 422
HL + + + Q+ PRR +I D+ + P P + +LKG S G
Sbjct: 52 HLKKVDNNLTEAQRFSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSG 111
Query: 423 ECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLF 482
E VA++G SG GKST++ +L Y + + S ++ + +L
Sbjct: 112 ELVAIMGPSGAGKSTLMNILAG-YRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLP 170
Query: 483 RGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIA 542
T+ + + + + +E+ + E+ + ++ L G + R SLSGGQ++R+A
Sbjct: 171 HLTVQEAMMVSAHLKLQEKDEGRREMV--KEILTAL--GLLSCANTRTGSLSGGQRKRLA 226
Query: 543 IARSLLREPAVLLLDEATSALDPHSERQVQAAL-DRASVGRTTITVSHRLSTIVNA--DR 599
IA L+ P V+ DE TS LD S QV + + A GR+ I H+ S + D+
Sbjct: 227 IALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQ 286
Query: 600 IICMDQGVIVEQG 612
+ + QG V +G
Sbjct: 287 LYVLSQGQCVYRG 299
Score = 40.3 bits (90), Expect = 0.043
Identities = 21/58 (36%), Positives = 33/58 (56%), Gaps = 6/58 (10%)
Query: 1060 ASGNFSMRDVEFCYPTRPSQR------VLKGIDLKMEAGKTIALVGSSGCGKSTILQL 1111
A+ N RD+ + P P R +LKGI K +G+ +A++G SG GKST++ +
Sbjct: 73 AAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNI 130
>AP001746-1|BAA95530.1| 674|Homo sapiens white protein homolog
(ATP-binding cassette transporter 8) protein.
Length = 674
Score = 72.9 bits (171), Expect = 7e-12
Identities = 68/253 (26%), Positives = 115/253 (45%), Gaps = 14/253 (5%)
Query: 369 HLIEREPKIDSLQQKGLTPRRVVGDILLEDVEFCYPSRPEVK------VLKGFSIHVKPG 422
HL + + + Q+ PRR +I D+ + P P + +LKG S G
Sbjct: 48 HLKKVDNNLTEAQRFSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSG 107
Query: 423 ECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLF 482
E VA++G SG GKST++ +L Y + + S ++ + +L
Sbjct: 108 ELVAIMGPSGAGKSTLMNILAG-YRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLP 166
Query: 483 RGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIA 542
T+ + + + + +E+ + E+ + ++ L G + R SLSGGQ++R+A
Sbjct: 167 HLTVQEAMMVSAHLKLQEKDEGRREMV--KEILTAL--GLLSCANTRTGSLSGGQRKRLA 222
Query: 543 IARSLLREPAVLLLDEATSALDPHSERQVQAAL-DRASVGRTTITVSHRLSTIVNA--DR 599
IA L+ P V+ DE TS LD S QV + + A GR+ I H+ S + D+
Sbjct: 223 IALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQ 282
Query: 600 IICMDQGVIVEQG 612
+ + QG V +G
Sbjct: 283 LYVLSQGQCVYRG 295
Score = 40.3 bits (90), Expect = 0.043
Identities = 21/58 (36%), Positives = 33/58 (56%), Gaps = 6/58 (10%)
Query: 1060 ASGNFSMRDVEFCYPTRPSQR------VLKGIDLKMEAGKTIALVGSSGCGKSTILQL 1111
A+ N RD+ + P P R +LKGI K +G+ +A++G SG GKST++ +
Sbjct: 69 AAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNI 126
>AJ289137-1|CAC00730.1| 674|Homo sapiens ATP-binding cassette
transporter, sub-family G member 1 protein.
Length = 674
Score = 72.9 bits (171), Expect = 7e-12
Identities = 68/253 (26%), Positives = 115/253 (45%), Gaps = 14/253 (5%)
Query: 369 HLIEREPKIDSLQQKGLTPRRVVGDILLEDVEFCYPSRPEVK------VLKGFSIHVKPG 422
HL + + + Q+ PRR +I D+ + P P + +LKG S G
Sbjct: 48 HLKKVDNNLTEAQRFSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSG 107
Query: 423 ECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLF 482
E VA++G SG GKST++ +L Y + + S ++ + +L
Sbjct: 108 ELVAIMGPSGAGKSTLMNILAG-YRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLP 166
Query: 483 RGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIA 542
T+ + + + + +E+ + E+ + ++ L G + R SLSGGQ++R+A
Sbjct: 167 HLTVQEAMMVSAHLKLQEKDEGRREMV--KEILTAL--GLLSCANTRTGSLSGGQRKRLA 222
Query: 543 IARSLLREPAVLLLDEATSALDPHSERQVQAAL-DRASVGRTTITVSHRLSTIVNA--DR 599
IA L+ P V+ DE TS LD S QV + + A GR+ I H+ S + D+
Sbjct: 223 IALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQ 282
Query: 600 IICMDQGVIVEQG 612
+ + QG V +G
Sbjct: 283 LYVLSQGQCVYRG 295
Score = 40.3 bits (90), Expect = 0.043
Identities = 21/58 (36%), Positives = 33/58 (56%), Gaps = 6/58 (10%)
Query: 1060 ASGNFSMRDVEFCYPTRPSQR------VLKGIDLKMEAGKTIALVGSSGCGKSTILQL 1111
A+ N RD+ + P P R +LKGI K +G+ +A++G SG GKST++ +
Sbjct: 69 AAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNI 126
>AF323664-1|AAK28842.1| 677|Homo sapiens ATP-binding cassette
transporter G1 variant V protein.
Length = 677
Score = 72.9 bits (171), Expect = 7e-12
Identities = 68/253 (26%), Positives = 115/253 (45%), Gaps = 14/253 (5%)
Query: 369 HLIEREPKIDSLQQKGLTPRRVVGDILLEDVEFCYPSRPEVK------VLKGFSIHVKPG 422
HL + + + Q+ PRR +I D+ + P P + +LKG S G
Sbjct: 63 HLKKVDNNLTEAQRFSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSG 122
Query: 423 ECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLF 482
E VA++G SG GKST++ +L Y + + S ++ + +L
Sbjct: 123 ELVAIMGPSGAGKSTLMNILAG-YRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLP 181
Query: 483 RGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIA 542
T+ + + + + +E+ + E+ + ++ L G + R SLSGGQ++R+A
Sbjct: 182 HLTVQEAMMVSAHLKLQEKDEGRREMV--KEILTAL--GLLSCANTRTGSLSGGQRKRLA 237
Query: 543 IARSLLREPAVLLLDEATSALDPHSERQVQAAL-DRASVGRTTITVSHRLSTIVNA--DR 599
IA L+ P V+ DE TS LD S QV + + A GR+ I H+ S + D+
Sbjct: 238 IALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQ 297
Query: 600 IICMDQGVIVEQG 612
+ + QG V +G
Sbjct: 298 LYVLSQGQCVYRG 310
Score = 40.3 bits (90), Expect = 0.043
Identities = 21/58 (36%), Positives = 33/58 (56%), Gaps = 6/58 (10%)
Query: 1060 ASGNFSMRDVEFCYPTRPSQR------VLKGIDLKMEAGKTIALVGSSGCGKSTILQL 1111
A+ N RD+ + P P R +LKGI K +G+ +A++G SG GKST++ +
Sbjct: 84 AAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNI 141
>AF323663-1|AAK28841.1| 662|Homo sapiens ATP-binding cassette
transporter G1 variant IV protein.
Length = 662
Score = 72.9 bits (171), Expect = 7e-12
Identities = 68/253 (26%), Positives = 115/253 (45%), Gaps = 14/253 (5%)
Query: 369 HLIEREPKIDSLQQKGLTPRRVVGDILLEDVEFCYPSRPEVK------VLKGFSIHVKPG 422
HL + + + Q+ PRR +I D+ + P P + +LKG S G
Sbjct: 48 HLKKVDNNLTEAQRFSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSG 107
Query: 423 ECVALVGSSGCGKSTVLQLLQRLYDPQAGSVXXXXXXXXXXXXSWLRSSLGVVGQEPVLF 482
E VA++G SG GKST++ +L Y + + S ++ + +L
Sbjct: 108 ELVAIMGPSGAGKSTLMNILAG-YRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLP 166
Query: 483 RGTIYDNIAIGSPEATREEIQRVAEIAYAHDFISLLPNGYDTVIGERGASLSGGQKQRIA 542
T+ + + + + +E+ + E+ + ++ L G + R SLSGGQ++R+A
Sbjct: 167 HLTVQEAMMVSAHLKLQEKDEGRREMV--KEILTAL--GLLSCANTRTGSLSGGQRKRLA 222
Query: 543 IARSLLREPAVLLLDEATSALDPHSERQVQAAL-DRASVGRTTITVSHRLSTIVNA--DR 599
IA L+ P V+ DE TS LD S QV + + A GR+ I H+ S + D+
Sbjct: 223 IALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQ 282
Query: 600 IICMDQGVIVEQG 612
+ + QG V +G
Sbjct: 283 LYVLSQGQCVYRG 295
Score = 40.3 bits (90), Expect = 0.043
Identities = 21/58 (36%), Positives = 33/58 (56%), Gaps = 6/58 (10%)
Query: 1060 ASGNFSMRDVEFCYPTRPSQR------VLKGIDLKMEAGKTIALVGSSGCGKSTILQL 1111
A+ N RD+ + P P R +LKGI K +G+ +A++G SG GKST++ +
Sbjct: 69 AAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNI 126
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.322 0.136 0.397
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 161,981,501
Number of Sequences: 224733
Number of extensions: 6493167
Number of successful extensions: 15617
Number of sequences better than 10.0: 440
Number of HSP's better than 10.0 without gapping: 427
Number of HSP's successfully gapped in prelim test: 13
Number of HSP's that attempted gapping in prelim test: 12776
Number of HSP's gapped (non-prelim): 1870
length of query: 1258
length of database: 73,234,838
effective HSP length: 99
effective length of query: 1159
effective length of database: 50,986,271
effective search space: 59093088089
effective search space used: 59093088089
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.9 bits)
S2: 71 (32.7 bits)
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