Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA000721-TA|BGIBMGA000721-PA|IPR011904|Acetate--CoA
ligase, IPR000873|AMP-dependent synthetase and ligase
(714 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q9NR19 Cluster: Acetyl-coenzyme A synthetase, cytoplasm... 580 e-164
UniRef50_Q01L46 Cluster: H0502B11.5 protein; n=5; Magnoliophyta|... 476 e-133
UniRef50_Q89WV5 Cluster: Acetyl-coenzyme A synthetase; n=105; Ba... 456 e-127
UniRef50_Q8YJ48 Cluster: Acetyl-coenzyme A synthetase; n=48; cel... 450 e-125
UniRef50_Q4QBC0 Cluster: Acetyl-CoA synthetase, putative; n=6; E... 426 e-117
UniRef50_Q8EYG2 Cluster: Acetyl-coenzyme A synthetase; n=76; cel... 424 e-117
UniRef50_Q55404 Cluster: Acetyl-coenzyme A synthetase; n=89; cel... 421 e-116
UniRef50_Q01CP6 Cluster: Acyl-CoA synthetase; n=6; Eukaryota|Rep... 414 e-114
UniRef50_Q82EL5 Cluster: Acetyl-coenzyme A synthetase; n=28; cel... 411 e-113
UniRef50_Q8KBY0 Cluster: Acetyl-coenzyme A synthetase; n=44; cel... 409 e-112
UniRef50_O67872 Cluster: Acetyl-coenzyme A synthetase; n=5; cell... 404 e-111
UniRef50_A7ATQ7 Cluster: Acetyl-CoA synthetase, putative; n=1; B... 401 e-110
UniRef50_Q0I9W4 Cluster: Acetate--CoA ligase; n=19; cellular org... 396 e-109
UniRef50_A6G1J4 Cluster: Acetate--CoA ligase; n=1; Plesiocystis ... 392 e-107
UniRef50_Q9PMD2 Cluster: Acetyl-coenzyme A synthetase; n=143; ce... 392 e-107
UniRef50_O25686 Cluster: Acetyl-coenzyme A synthetase; n=40; Bac... 392 e-107
UniRef50_Q27549 Cluster: Acetyl-coenzyme A synthetase; n=7; Apic... 392 e-107
UniRef50_Q8ZUB3 Cluster: Acetyl-coenzyme A synthetase; n=4; Arch... 375 e-102
UniRef50_Q93LL2 Cluster: Acetyl-coenzyme A synthetase; n=165; ce... 366 e-100
UniRef50_Q9NUB1 Cluster: Acetyl-coenzyme A synthetase 2-like, mi... 355 2e-96
UniRef50_Q5FTV0 Cluster: Acetyl-coenzyme A synthetase; n=1; Gluc... 351 5e-95
UniRef50_A2E702 Cluster: AMP-binding enzyme family protein; n=2;... 351 5e-95
UniRef50_Q01574 Cluster: Acetyl-coenzyme A synthetase 1; n=40; F... 347 8e-94
UniRef50_O93730 Cluster: Acetyl-coenzyme A synthetase; n=11; Arc... 344 6e-93
UniRef50_P27095 Cluster: Acetyl-coenzyme A synthetase; n=12; cel... 341 4e-92
UniRef50_A5UUT7 Cluster: Acetate--CoA ligase; n=2; Roseiflexus|R... 337 7e-91
UniRef50_P55912 Cluster: Propionate--CoA ligase; n=57; Bacteria|... 336 9e-91
UniRef50_Q9HQU8 Cluster: Acetyl-CoA synthetase; n=11; root|Rep: ... 333 8e-90
UniRef50_Q869S4 Cluster: Similar to Bradyrhizobium japonicum. Ac... 329 1e-88
UniRef50_UPI00015B60D2 Cluster: PREDICTED: similar to ENSANGP000... 324 7e-87
UniRef50_Q9VC92 Cluster: CG6432-PA; n=7; cellular organisms|Rep:... 316 1e-84
UniRef50_Q8SRZ9 Cluster: ACETYLCOENZYME A SYNTHETASE; n=1; Encep... 316 1e-84
UniRef50_Q871W2 Cluster: Related to acetyl coenzyme A synthetase... 312 2e-83
UniRef50_Q1JYJ4 Cluster: AMP-dependent synthetase and ligase; n=... 296 2e-78
UniRef50_Q247U0 Cluster: AMP-binding enzyme family protein; n=1;... 287 9e-76
UniRef50_A7HB74 Cluster: AMP-dependent synthetase and ligase; n=... 281 6e-74
UniRef50_Q127M4 Cluster: AMP-dependent synthetase and ligase; n=... 277 8e-73
UniRef50_A1CSK5 Cluster: Acyl-CoA synthetase, putative; n=7; Pez... 276 1e-72
UniRef50_Q4J9J7 Cluster: Acetyl-coenzyme A synthetase; n=4; Sulf... 271 5e-71
UniRef50_Q6LEZ6 Cluster: Acetyl-coenzyme a synthetase; n=3; Plas... 266 2e-69
UniRef50_A5K2B0 Cluster: Acetyl-CoA synthetase, putative; n=1; P... 264 6e-69
UniRef50_Q7RL40 Cluster: Acetate--CoA ligase-related; n=3; Plasm... 261 5e-68
UniRef50_A7RH51 Cluster: Predicted protein; n=1; Nematostella ve... 261 5e-68
UniRef50_Q5QYS0 Cluster: Propionyl-CoA synthetase; n=1; Idiomari... 254 5e-66
UniRef50_A5WC66 Cluster: Propionate--CoA ligase; n=3; Psychrobac... 254 8e-66
UniRef50_Q9H6R3 Cluster: CDNA: FLJ21963 fis, clone HEP05583; n=3... 250 1e-64
UniRef50_Q4ST59 Cluster: Chromosome undetermined SCAF14300, whol... 248 3e-64
UniRef50_Q0JDG8 Cluster: Os04g0404800 protein; n=8; cellular org... 248 3e-64
UniRef50_Q978X5 Cluster: Acetyl-CoA synthetase; n=3; cellular or... 248 5e-64
UniRef50_P28812 Cluster: Uncharacterized protein PA3568; n=81; c... 245 3e-63
UniRef50_Q9RX55 Cluster: Acetyl-CoA synthase; n=4; cellular orga... 244 5e-63
UniRef50_A7DME3 Cluster: AMP-dependent synthetase and ligase; n=... 244 5e-63
UniRef50_A0JS90 Cluster: AMP-dependent synthetase and ligase; n=... 241 5e-62
UniRef50_Q22UI3 Cluster: AMP-binding enzyme family protein; n=6;... 238 4e-61
UniRef50_A2TC85 Cluster: AMP-dependent synthetase and ligase; n=... 236 1e-60
UniRef50_Q8ZV36 Cluster: Acetyl-coenzyme A synthetase; n=4; Pyro... 235 2e-60
UniRef50_Q5V498 Cluster: Acyl-coenzyme A synthetases; n=5; Halob... 232 2e-59
UniRef50_Q81Q80 Cluster: Acetoacetyl-CoA synthase, putative; n=1... 231 4e-59
UniRef50_Q5P1M8 Cluster: Acyl-CoA synthetase; n=2; Azoarcus|Rep:... 230 1e-58
UniRef50_Q140P4 Cluster: Putative acetyl-CoA synthetase and liga... 229 2e-58
UniRef50_Q67QN3 Cluster: Acetyl-coenzyme A synthetase; n=6; Bact... 226 2e-57
UniRef50_Q6L1R5 Cluster: Acetyl-coenzyme A synthetase; n=1; Picr... 215 3e-54
UniRef50_Q9YCA8 Cluster: Acetyl-coenzyme A synthetase; n=2; Arch... 215 5e-54
UniRef50_Q3E187 Cluster: AMP-dependent synthetase and ligase:Eno... 213 1e-53
UniRef50_Q4PHQ0 Cluster: Putative uncharacterized protein; n=1; ... 213 1e-53
UniRef50_Q4WAZ5 Cluster: Acetate-CoA ligase, putative; n=1; Aspe... 211 4e-53
UniRef50_A3WE14 Cluster: Acetyl-coenzyme A synthetase; n=1; Eryt... 209 2e-52
UniRef50_A5UY60 Cluster: AMP-dependent synthetase and ligase; n=... 208 4e-52
UniRef50_Q5BYW0 Cluster: SJCHGC03435 protein; n=1; Schistosoma j... 207 9e-52
UniRef50_Q54YU1 Cluster: Putative uncharacterized protein; n=1; ... 196 1e-48
UniRef50_Q0FW37 Cluster: Acyl-CoA synthetase; n=1; Roseovarius s... 193 1e-47
UniRef50_Q39MW7 Cluster: AMP-dependent synthetase and ligase; n=... 192 4e-47
UniRef50_Q2RGI0 Cluster: Acetyl-coenzyme A synthetase; n=1; Moor... 189 2e-46
UniRef50_A3W6I7 Cluster: AMP-dependent synthetase and ligase; n=... 182 3e-44
UniRef50_Q97WQ9 Cluster: Acetyl-CoA synthetase; n=3; Sulfolobus|... 174 6e-42
UniRef50_Q39MD9 Cluster: AMP-dependent synthetase and ligase; n=... 167 7e-40
UniRef50_Q7WPR9 Cluster: AMP-binding enzyme; n=5; Burkholderiale... 167 9e-40
UniRef50_Q0RXR5 Cluster: Acetate--CoA ligase; n=1; Rhodococcus s... 167 1e-39
UniRef50_Q6L1R6 Cluster: Acetyl-coenzyme A synthetase; n=1; Picr... 164 6e-39
UniRef50_A4WKF4 Cluster: AMP-dependent synthetase and ligase; n=... 164 8e-39
UniRef50_Q6A9A4 Cluster: Acetyl-coenzyme A synthetase; n=1; Prop... 163 2e-38
UniRef50_UPI0000E4931E Cluster: PREDICTED: hypothetical protein,... 161 6e-38
UniRef50_Q9HLJ9 Cluster: Acetyl-CoA synthetase related protein; ... 159 2e-37
UniRef50_Q8ZV30 Cluster: Acetyl-coenzyme A synthetase; n=6; Ther... 157 1e-36
UniRef50_P39062 Cluster: Acetyl-coenzyme A synthetase; n=41; cel... 153 2e-35
UniRef50_Q557A3 Cluster: Putative uncharacterized protein; n=2; ... 151 6e-35
UniRef50_Q86AI5 Cluster: Similar to Bradyrhizobium japonicum. Ac... 149 3e-34
UniRef50_A1S0M6 Cluster: AMP-dependent synthetase and ligase; n=... 146 2e-33
UniRef50_Q01NM8 Cluster: AMP-dependent synthetase and ligase; n=... 146 2e-33
UniRef50_Q55GU6 Cluster: Putative acetyl-CoA synthetase; n=3; Di... 144 7e-33
UniRef50_Q75JX6 Cluster: Similar to Vibrio cholerae. PrpE protei... 142 2e-32
UniRef50_A6C4K4 Cluster: Acetate--CoA ligase; n=1; Planctomyces ... 136 2e-30
UniRef50_Q5UWB7 Cluster: Acyl-coenzyme A synthetases; n=2; Halob... 134 6e-30
UniRef50_A4A7V6 Cluster: Acetyl-coenzyme A synthetase/GroES-like... 133 1e-29
UniRef50_Q4J776 Cluster: Acetyl-coenzyme A synthetase; n=2; Sulf... 133 2e-29
UniRef50_Q39T59 Cluster: AMP-dependent synthetase and ligase; n=... 130 1e-28
UniRef50_A4TUE0 Cluster: Acyl-coenzyme A synthetases/AMP-(Fatty)... 129 2e-28
UniRef50_Q72J94 Cluster: Acetyl-coenzyme A synthetase; n=2; Ther... 129 3e-28
UniRef50_O30042 Cluster: Acetyl-CoA synthetase; n=1; Archaeoglob... 128 4e-28
UniRef50_UPI0000510398 Cluster: COG0365: Acyl-coenzyme A synthet... 128 7e-28
UniRef50_A4QIB2 Cluster: Putative uncharacterized protein; n=1; ... 126 2e-27
UniRef50_Q0S3K9 Cluster: Acetoacetate--CoA ligase; n=10; Actinom... 124 8e-27
UniRef50_Q9KLB7 Cluster: Acetyl-CoA synthase; n=21; Vibrio|Rep: ... 124 1e-26
UniRef50_Q87H07 Cluster: Acetyl-CoA synthase; n=13; Vibrionales|... 124 1e-26
UniRef50_Q4P432 Cluster: Putative uncharacterized protein; n=1; ... 122 3e-26
UniRef50_Q9HI39 Cluster: Probable SA protein; n=4; Thermoplasma|... 121 6e-26
UniRef50_Q7S7A6 Cluster: Putative uncharacterized protein NCU014... 119 2e-25
UniRef50_Q6U666 Cluster: Putative uncharacterized protein; n=1; ... 118 4e-25
UniRef50_Q4JHB4 Cluster: Acetoacyl-CoA synthetase; n=2; cellular... 118 7e-25
UniRef50_Q5LKI0 Cluster: Benzoate-coenzyme A ligase; n=33; Bacte... 116 3e-24
UniRef50_Q1V1I6 Cluster: Acetoacetyl-CoA synthase; n=2; Bacteria... 116 3e-24
UniRef50_Q55RP2 Cluster: Putative uncharacterized protein; n=2; ... 116 3e-24
UniRef50_Q8ESW2 Cluster: Acetoacetyl-CoA synthetase; n=1; Oceano... 115 5e-24
UniRef50_Q97WK0 Cluster: Acetyl-CoA synthetase; n=4; Sulfolobace... 114 9e-24
UniRef50_Q397N8 Cluster: Acetoacetyl-CoA synthase; n=5; Bacteria... 113 1e-23
UniRef50_Q8G3C8 Cluster: Acetoacetyl-CoA synthase; n=36; Proteob... 113 2e-23
UniRef50_Q5KW92 Cluster: Acetyl-CoA synthetase; n=2; Geobacillus... 113 2e-23
UniRef50_A0LVM6 Cluster: Acetoacetyl-CoA synthase; n=5; Bacteria... 113 2e-23
UniRef50_UPI00005102FE Cluster: COG0365: Acyl-coenzyme A synthet... 112 4e-23
UniRef50_A0KEL2 Cluster: Acetoacetyl-CoA synthase; n=2; Aeromona... 111 6e-23
UniRef50_UPI000038E2AC Cluster: hypothetical protein Faci_030001... 109 3e-22
UniRef50_Q8IWD2 Cluster: Acetoacetyl-CoA synthetase; n=53; Eumet... 109 3e-22
UniRef50_Q21PV0 Cluster: Bifunctional acetoacetyl-CoA synthase/A... 109 3e-22
UniRef50_Q11M02 Cluster: Acetoacetyl-CoA synthase; n=7; Proteoba... 108 4e-22
UniRef50_Q2GPB1 Cluster: Putative uncharacterized protein; n=1; ... 108 6e-22
UniRef50_Q0SJB1 Cluster: Acetoacetate--CoA ligase; n=1; Rhodococ... 107 1e-21
UniRef50_O28981 Cluster: Acetyl-CoA synthetase; n=2; Archaea|Rep... 107 1e-21
UniRef50_O34613 Cluster: YtcI; n=53; Bacillales|Rep: YtcI - Baci... 106 2e-21
UniRef50_Q1AT30 Cluster: AMP-dependent synthetase and ligase; n=... 106 2e-21
UniRef50_A0Z1E2 Cluster: Acetyl-coenzyme A synthetase; n=1; mari... 106 2e-21
UniRef50_Q4PHX8 Cluster: Putative uncharacterized protein; n=1; ... 105 3e-21
UniRef50_A0T9G0 Cluster: AMP-dependent synthetase and ligase; n=... 105 4e-21
UniRef50_A3VFU7 Cluster: Acetoacetyl-CoA synthase; n=1; Rhodobac... 105 5e-21
UniRef50_Q9Z3R3 Cluster: Acetoacetyl-coenzyme A synthetase; n=7;... 105 5e-21
UniRef50_A0LK08 Cluster: AMP-dependent synthetase and ligase; n=... 103 2e-20
UniRef50_A6W2Z8 Cluster: Acetoacetyl-CoA synthase; n=1; Marinomo... 103 2e-20
UniRef50_A0QZD4 Cluster: Acetyl-coenzyme A synthetase; n=3; Cory... 103 2e-20
UniRef50_A5WDS3 Cluster: AMP-dependent synthetase and ligase; n=... 102 3e-20
UniRef50_A1ID66 Cluster: Acetyl-coenzyme A synthetase; n=1; Cand... 102 4e-20
UniRef50_Q5KZW6 Cluster: Acetoacetyl-CoA synthetase; n=20; Bacte... 101 9e-20
UniRef50_Q2J785 Cluster: Acetoacetyl-CoA synthase; n=5; Actinoba... 100 2e-19
UniRef50_Q1ATG8 Cluster: AMP-dependent synthetase and ligase; n=... 99 2e-19
UniRef50_Q0RL74 Cluster: Putative long-chain-fatty-acid CoA liga... 99 2e-19
UniRef50_Q97WS5 Cluster: Acetyl-CoA synthetase; n=4; Sulfolobus|... 99 4e-19
UniRef50_Q9KZN9 Cluster: Acetoacetyl-CoA synthetase; n=5; Actino... 99 5e-19
UniRef50_Q0A597 Cluster: AMP-dependent synthetase and ligase; n=... 98 6e-19
UniRef50_Q8R8N5 Cluster: Acyl-CoA synthetases (AMP-forming)/AMP-... 98 8e-19
UniRef50_Q3W9E5 Cluster: AMP-dependent synthetase and ligase; n=... 98 8e-19
UniRef50_Q5V0W0 Cluster: Medium-chain fatty acid-CoA ligase; n=5... 98 8e-19
UniRef50_A3JB96 Cluster: Acetyl-coenzyme A synthetase; n=6; Gamm... 97 1e-18
UniRef50_Q91VA0-2 Cluster: Isoform 2 of Q91VA0 ; n=3; Euarchonto... 97 2e-18
UniRef50_Q89HB8 Cluster: Bll6076 protein; n=17; Bacteria|Rep: Bl... 97 2e-18
UniRef50_Q12D64 Cluster: AMP-dependent synthetase and ligase; n=... 97 2e-18
UniRef50_UPI00005104B2 Cluster: COG0318: Acyl-CoA synthetases (A... 96 3e-18
UniRef50_Q5GMK0 Cluster: Fatty-acid-CoA ligase; n=1; uncultured ... 96 3e-18
UniRef50_Q9A9L4 Cluster: Long-chain-fatty-acid--CoA ligase, puta... 95 4e-18
UniRef50_Q2FT08 Cluster: AMP-dependent synthetase and ligase; n=... 95 4e-18
UniRef50_Q0HLV4 Cluster: AMP-dependent synthetase and ligase; n=... 95 6e-18
UniRef50_Q3ABP3 Cluster: Long-chain-fatty-acid--CoA ligase; n=1;... 94 1e-17
UniRef50_Q1ITX8 Cluster: AMP-dependent synthetase and ligase; n=... 94 1e-17
UniRef50_A7JC22 Cluster: Predicted protein; n=1; Francisella tul... 93 2e-17
UniRef50_Q0CFH7 Cluster: Putative uncharacterized protein; n=1; ... 93 2e-17
UniRef50_Q97WU3 Cluster: Acetyl-CoA synthetase (Acetate-CoA liga... 93 2e-17
UniRef50_Q21UY9 Cluster: AMP-dependent synthetase and ligase; n=... 93 3e-17
UniRef50_Q1E700 Cluster: Putative uncharacterized protein; n=1; ... 92 4e-17
UniRef50_UPI000049951B Cluster: acyl-CoA synthetase; n=2; Entamo... 92 5e-17
UniRef50_Q8YBS1 Cluster: ACETYL-COENZYME A SYNTHETASE; n=38; Pro... 92 5e-17
UniRef50_Q7W0W3 Cluster: Acetyl-CoA synthetase; n=2; Bordetella|... 92 5e-17
UniRef50_A4T5I6 Cluster: Acetoacetyl-CoA synthase; n=2; Mycobact... 92 5e-17
UniRef50_Q97YK9 Cluster: Acetyl-CoA synthetase; n=4; Sulfolobus|... 92 5e-17
UniRef50_Q8KUH3 Cluster: Polyketide synthase; n=2; Bacteria|Rep:... 91 7e-17
UniRef50_Q83DG9 Cluster: Acetoacetyl-CoA synthase; n=5; Gammapro... 91 9e-17
UniRef50_Q12HA7 Cluster: Acetoacetyl-CoA synthase precursor; n=6... 91 9e-17
UniRef50_Q5YX39 Cluster: Putative acyl-CoA synthetase; n=1; Noca... 91 1e-16
UniRef50_A0Z8S4 Cluster: Acyl-CoA synthase; n=1; marine gamma pr... 91 1e-16
UniRef50_Q7KWS0 Cluster: Similar to Rhizobium loti (Mesorhizobiu... 91 1e-16
UniRef50_UPI000155F3B9 Cluster: PREDICTED: hypothetical protein;... 90 2e-16
UniRef50_Q89DS2 Cluster: Acetyl-coenzyme A synthetase; n=1; Brad... 90 2e-16
UniRef50_A3VKE9 Cluster: Acyl-CoA synthase; n=5; Proteobacteria|... 90 2e-16
UniRef50_A1VP64 Cluster: Acetoacetyl-CoA synthase; n=2; Comamona... 90 2e-16
UniRef50_Q86JR9 Cluster: Putative uncharacterized protein; n=2; ... 90 2e-16
UniRef50_Q5CD72 Cluster: Acyl-CoA synthetase; n=3; Pseudomonadal... 89 4e-16
UniRef50_Q0SGA4 Cluster: Acetate--CoA ligase; n=2; Corynebacteri... 89 4e-16
UniRef50_A0FSJ3 Cluster: AMP-dependent synthetase and ligase; n=... 89 5e-16
UniRef50_Q2GYG4 Cluster: Putative uncharacterized protein; n=1; ... 89 5e-16
UniRef50_O29286 Cluster: Acetyl-CoA synthetase; n=1; Archaeoglob... 89 5e-16
UniRef50_A7BL94 Cluster: Beta-ketoacyl synthase; n=1; Beggiatoa ... 88 7e-16
UniRef50_Q98AG0 Cluster: Acetyl-CoA synthetase; n=48; Bacteria|R... 88 9e-16
UniRef50_Q89Y48 Cluster: Blr0107 protein; n=7; Alphaproteobacter... 88 9e-16
UniRef50_Q6MR22 Cluster: Long-chain fatty-acid-CoA ligase; n=1; ... 88 9e-16
UniRef50_Q4J553 Cluster: AMP-dependent synthetase and ligase; n=... 88 9e-16
UniRef50_A1SEZ8 Cluster: AMP-dependent synthetase and ligase; n=... 88 9e-16
UniRef50_Q2PC83 Cluster: Putative polyketide synthase; n=2; Acti... 87 1e-15
UniRef50_Q04R11 Cluster: Acyl-CoA synthetase; n=2; Leptospira bo... 87 1e-15
UniRef50_Q89T13 Cluster: Bll2237 protein; n=2; Bradyrhizobium|Re... 87 2e-15
UniRef50_Q0AL69 Cluster: AMP-dependent synthetase and ligase; n=... 87 2e-15
UniRef50_Q6DJK1 Cluster: MGC82117 protein; n=15; root|Rep: MGC82... 87 2e-15
UniRef50_Q67RT9 Cluster: Long-chain fatty-acid-CoA ligase; n=5; ... 87 2e-15
UniRef50_A4FDM8 Cluster: Modular polyketide synthase-; n=1; Sacc... 87 2e-15
UniRef50_O29418 Cluster: Long-chain-fatty-acid--CoA ligase; n=4;... 87 2e-15
UniRef50_A3Q3Y3 Cluster: AMP-dependent synthetase and ligase; n=... 86 3e-15
UniRef50_Q3IUK7 Cluster: Acyl-CoA synthetase I 5; n=2; Halobacte... 86 3e-15
UniRef50_UPI000038E2BB Cluster: hypothetical protein Faci_030016... 86 4e-15
UniRef50_Q5KZW0 Cluster: Long-chain fatty-acid-CoA ligase; n=6; ... 86 4e-15
UniRef50_Q1AV80 Cluster: AMP-dependent synthetase and ligase; n=... 86 4e-15
UniRef50_A3I408 Cluster: Long-chain fatty-acid-CoA ligase; n=2; ... 86 4e-15
UniRef50_O30147 Cluster: Long-chain-fatty-acid--CoA ligase; n=1;... 86 4e-15
UniRef50_A7IKN7 Cluster: AMP-dependent synthetase and ligase; n=... 85 5e-15
UniRef50_A5Z6T7 Cluster: Putative uncharacterized protein; n=1; ... 85 5e-15
UniRef50_A1SPU7 Cluster: AMP-dependent synthetase and ligase; n=... 85 5e-15
UniRef50_Q5L252 Cluster: AMP-binding enzyme; n=3; Bacillaceae|Re... 85 6e-15
UniRef50_A3Q8J7 Cluster: AMP-dependent synthetase and ligase; n=... 85 6e-15
UniRef50_A1SK97 Cluster: AMP-dependent synthetase and ligase; n=... 85 6e-15
UniRef50_Q3W9D1 Cluster: AMP-dependent synthetase and ligase; n=... 85 8e-15
UniRef50_A1IB03 Cluster: Long-chain-fatty-acid--CoA ligase; n=1;... 85 8e-15
UniRef50_A0H8Z8 Cluster: AMP-dependent synthetase and ligase; n=... 85 8e-15
UniRef50_Q8ESG9 Cluster: Long-chain fatty-acid-CoA ligase; n=1; ... 84 1e-14
UniRef50_Q2B4D3 Cluster: Long-chain fatty-acid-CoA ligase; n=3; ... 84 1e-14
UniRef50_Q1GM48 Cluster: Acetoacetyl-CoA synthase; n=3; Proteoba... 84 1e-14
UniRef50_Q8L9Z5 Cluster: 4-coumarate-CoA ligase-like protein; n=... 84 1e-14
UniRef50_O29233 Cluster: Long-chain-fatty-acid--CoA ligase; n=1;... 84 1e-14
UniRef50_Q53FZ2 Cluster: Acyl-coenzyme A synthetase ACSM3, mitoc... 84 1e-14
UniRef50_UPI000065D652 Cluster: CDNA: FLJ21963 fis, clone HEP055... 84 1e-14
UniRef50_Q39P28 Cluster: AMP-dependent synthetase and ligase; n=... 84 1e-14
UniRef50_A3Q356 Cluster: AMP-dependent synthetase and ligase; n=... 84 1e-14
UniRef50_A1SP58 Cluster: AMP-dependent synthetase and ligase; n=... 84 1e-14
UniRef50_Q3IQ14 Cluster: Acyl-CoA synthetase II 4; n=1; Natronom... 84 1e-14
UniRef50_Q3WJL5 Cluster: AMP-dependent synthetase and ligase; n=... 83 2e-14
UniRef50_Q1AV60 Cluster: Benzoate-CoA ligase family; n=3; Bacter... 83 2e-14
UniRef50_Q0S6C5 Cluster: CoA synthetase; n=2; Rhodococcus|Rep: C... 83 2e-14
UniRef50_A3VRX0 Cluster: Acetoacetyl-CoA synthase; n=1; Parvular... 83 2e-14
UniRef50_A0V7F5 Cluster: AMP-dependent synthetase and ligase; n=... 83 2e-14
UniRef50_A6RVZ7 Cluster: Putative uncharacterized protein; n=1; ... 83 2e-14
UniRef50_UPI0000E88035 Cluster: acetyl-coenzyme A synthetase fam... 83 3e-14
UniRef50_Q0SGM6 Cluster: Long-chain-fatty-acid--CoA ligase; n=8;... 83 3e-14
UniRef50_UPI0001556387 Cluster: PREDICTED: similar to acyl-CoA s... 83 3e-14
UniRef50_A7HTP6 Cluster: AMP-dependent synthetase and ligase; n=... 83 3e-14
UniRef50_Q9FFE6 Cluster: AMP-binding protein; n=11; Brassicaceae... 83 3e-14
UniRef50_Q80W40 Cluster: Acyl-coenzyme A synthetase O-MACS, mito... 83 3e-14
UniRef50_Q18UZ8 Cluster: AMP-dependent synthetase and ligase; n=... 82 4e-14
UniRef50_Q12FZ3 Cluster: Benzoate-CoA ligase family; n=5; Burkho... 82 4e-14
UniRef50_A6G5C8 Cluster: Benzoate-CoA ligase family protein; n=1... 82 4e-14
UniRef50_Q399N2 Cluster: AMP-dependent synthetase and ligase; n=... 82 6e-14
UniRef50_Q1GWM8 Cluster: AMP-dependent synthetase and ligase; n=... 82 6e-14
UniRef50_Q13HM2 Cluster: Putative AMP-dependent synthetase and l... 82 6e-14
UniRef50_Q0RV51 Cluster: Probable synthetase/ligase; n=1; Rhodoc... 82 6e-14
UniRef50_A5V1C7 Cluster: AMP-dependent synthetase and ligase pre... 82 6e-14
UniRef50_A5UV13 Cluster: AMP-dependent synthetase and ligase; n=... 82 6e-14
UniRef50_A1GFR6 Cluster: AMP-dependent synthetase and ligase; n=... 82 6e-14
UniRef50_P38137 Cluster: Peroxisomal-coenzyme A synthetase; n=3;... 82 6e-14
UniRef50_Q88L97 Cluster: Long-chain-fatty-acid--CoA ligase, puta... 81 8e-14
UniRef50_Q5KY15 Cluster: Long-chain fatty-acid-CoA ligase; n=1; ... 81 8e-14
UniRef50_Q1YKS4 Cluster: Putative acyl coenzyme A synthetase, lo... 81 8e-14
UniRef50_Q0RMJ3 Cluster: Putative uncharacterized protein; n=1; ... 81 8e-14
UniRef50_A4FGY3 Cluster: Acyl-CoA synthase; n=2; Actinomycetales... 81 8e-14
UniRef50_A1ZSB8 Cluster: AMP-dependent synthetase and ligase; n=... 81 8e-14
UniRef50_A0YFX1 Cluster: Acyl-CoA synthase; n=2; Proteobacteria|... 81 8e-14
UniRef50_A7MBE6 Cluster: MGC179444 protein; n=1; Bos taurus|Rep:... 81 8e-14
UniRef50_Q2KHB5 Cluster: Putative uncharacterized protein; n=2; ... 81 8e-14
UniRef50_Q93H12 Cluster: Long-chain fatty acid--CoA ligase; n=3;... 81 1e-13
UniRef50_Q3WAU4 Cluster: AMP-dependent synthetase and ligase; n=... 81 1e-13
UniRef50_Q0LEJ2 Cluster: AMP-dependent synthetase and ligase; n=... 81 1e-13
UniRef50_A1T3N1 Cluster: AMP-dependent synthetase and ligase; n=... 81 1e-13
UniRef50_A7QIU3 Cluster: Chromosome chr2 scaffold_105, whole gen... 81 1e-13
UniRef50_O07899 Cluster: Vibriobactin-specific 2,3-dihydroxybenz... 81 1e-13
UniRef50_P38135 Cluster: Short-chain-fatty-acid--CoA ligase; n=2... 81 1e-13
UniRef50_UPI000038CCA4 Cluster: COG0318: Acyl-CoA synthetases (A... 81 1e-13
UniRef50_Q5E2J5 Cluster: Long-chain-fatty-acid--CoA ligase; n=4;... 81 1e-13
UniRef50_Q3IWF1 Cluster: AMP-binding enzyme; n=6; Alphaproteobac... 81 1e-13
UniRef50_A6CKR2 Cluster: Long-chain fatty-acid-CoA ligase; n=1; ... 81 1e-13
UniRef50_Q97VU7 Cluster: Medium-chain-fatty-acid--CoA ligase; n=... 81 1e-13
UniRef50_Q67T49 Cluster: Medium-chain fatty-acid-CoA ligase; n=2... 80 2e-13
UniRef50_Q39TG8 Cluster: AMP-dependent synthetase and ligase; n=... 80 2e-13
UniRef50_Q13I80 Cluster: Putative AMP-dependent synthetase and l... 80 2e-13
UniRef50_A6LV83 Cluster: AMP-dependent synthetase and ligase; n=... 80 2e-13
UniRef50_A0QPA1 Cluster: AMP-dependent synthetase and ligase; n=... 80 2e-13
UniRef50_O74976 Cluster: Putative peroxisomal-coenzyme A synthet... 80 2e-13
UniRef50_UPI0000E46385 Cluster: PREDICTED: hypothetical protein,... 80 2e-13
UniRef50_Q8ERX1 Cluster: Long-chain fatty-acid-CoA ligase; n=47;... 80 2e-13
UniRef50_Q5LP47 Cluster: AMP-binding enzyme; n=27; Bacteria|Rep:... 80 2e-13
UniRef50_Q3M5Z4 Cluster: AMP-dependent synthetase and ligase; n=... 80 2e-13
UniRef50_Q138P7 Cluster: AMP-dependent synthetase and ligase; n=... 80 2e-13
UniRef50_P71716 Cluster: BIFUNCTIONAL ENZYME MBTA: SALICYL-AMP L... 80 2e-13
UniRef50_Q0SEC4 Cluster: Possible long-chain-fatty-acid-CoA liga... 80 2e-13
UniRef50_A7H9R1 Cluster: AMP-dependent synthetase and ligase; n=... 80 2e-13
UniRef50_A4AHB6 Cluster: Putative acid-CoA ligase; n=1; marine a... 80 2e-13
UniRef50_A3K0X6 Cluster: Benzoate-coenzyme A ligase; n=1; Sagitt... 80 2e-13
UniRef50_Q9RTR4 Cluster: Long-chain fatty acid--CoA ligase; n=4;... 79 3e-13
UniRef50_Q3AEI5 Cluster: Medium-chain-fatty-acid--CoA ligase; n=... 79 3e-13
UniRef50_Q0RLX3 Cluster: Putative acyl-CoA synthetase, long-chai... 79 3e-13
UniRef50_Q9VXZ8 Cluster: CG9009-PA; n=5; Eumetazoa|Rep: CG9009-P... 79 3e-13
UniRef50_UPI0000165EEF Cluster: acyl-CoA synthase; n=1; Deinococ... 79 4e-13
UniRef50_Q0KDD5 Cluster: Acyl-CoA synthetase (AMP-forming)/AMP-a... 79 4e-13
UniRef50_A7IE14 Cluster: AMP-dependent synthetase and ligase; n=... 79 4e-13
UniRef50_O02200 Cluster: Putative uncharacterized protein; n=3; ... 79 4e-13
UniRef50_Q8ZES9 Cluster: Long-chain-fatty-acid--CoA ligase; n=20... 79 4e-13
UniRef50_UPI0000DB771C Cluster: PREDICTED: similar to CG9009-PA;... 79 5e-13
UniRef50_Q8KGC2 Cluster: Long-chain-fatty-acid--CoA ligase; n=8;... 79 5e-13
UniRef50_Q89UT2 Cluster: Fatty acid CoA-ligase; n=6; Bradyrhizob... 79 5e-13
UniRef50_Q7WBV5 Cluster: Putative ligase; n=2; Bordetella|Rep: P... 79 5e-13
UniRef50_Q2RJ14 Cluster: AMP-dependent synthetase and ligase; n=... 79 5e-13
UniRef50_A7I4G3 Cluster: AMP-dependent synthetase and ligase; n=... 79 5e-13
UniRef50_UPI000050F844 Cluster: COG0318: Acyl-CoA synthetases (A... 78 7e-13
UniRef50_Q2G4B6 Cluster: AMP-dependent synthetase and ligase; n=... 78 7e-13
UniRef50_Q9L8H4 Cluster: Actinomycin synthetase III; n=1; Strept... 78 7e-13
UniRef50_Q2J0Z7 Cluster: AMP-dependent synthetase and ligase; n=... 78 7e-13
UniRef50_A3SDR1 Cluster: Acyl-CoA synthase; n=3; Sulfitobacter|R... 78 7e-13
UniRef50_A1WPM5 Cluster: AMP-dependent synthetase and ligase; n=... 78 7e-13
UniRef50_A2XYW7 Cluster: Putative uncharacterized protein; n=1; ... 78 7e-13
UniRef50_Q7W0Z1 Cluster: Putative long-chain-fatty-acid-CoA liga... 78 9e-13
UniRef50_A3JBQ3 Cluster: AMP-dependent synthetase and ligase; n=... 78 9e-13
UniRef50_A4RRN4 Cluster: Predicted protein; n=2; Ostreococcus|Re... 78 9e-13
UniRef50_Q5LVA1 Cluster: 4-coumarate:CoA ligase; n=5; Rhodobacte... 77 1e-12
UniRef50_A3UNV4 Cluster: Acetyl-CoA synthase; n=5; Vibrionaceae|... 77 1e-12
UniRef50_A0U111 Cluster: AMP-dependent synthetase and ligase; n=... 77 1e-12
UniRef50_Q2Y4D8 Cluster: Acetyl-CoA synthetase homologue; n=1; u... 77 1e-12
UniRef50_Q8XBV3 Cluster: Enterobactin synthetase component E (En... 77 1e-12
UniRef50_Q9RXH7 Cluster: Fatty-acid--CoA ligase, putative; n=1; ... 77 2e-12
UniRef50_Q5YWI7 Cluster: Putative acyl-CoA synthetase; n=1; Noca... 77 2e-12
UniRef50_Q5L0D6 Cluster: Fatty acid-CoA ligase; n=16; Bacillacea... 77 2e-12
UniRef50_Q310X4 Cluster: Long-chain-fatty-acid--CoA ligase; n=4;... 77 2e-12
UniRef50_Q84HC5 Cluster: Adenylate ligase; n=3; Actinomycetales|... 77 2e-12
UniRef50_Q2IWT3 Cluster: AMP-dependent synthetase and ligase; n=... 77 2e-12
UniRef50_Q24QW2 Cluster: Putative uncharacterized protein; n=1; ... 77 2e-12
UniRef50_Q21B05 Cluster: AMP-dependent synthetase and ligase; n=... 77 2e-12
UniRef50_Q0S0V4 Cluster: Possible CoA-dependent ligase; n=1; Rho... 77 2e-12
UniRef50_Q0LRR9 Cluster: AMP-dependent synthetase and ligase; n=... 77 2e-12
UniRef50_A5V7K3 Cluster: AMP-dependent synthetase and ligase pre... 77 2e-12
UniRef50_A4ABA8 Cluster: Long-chain-fatty-acid--CoA ligase; n=1;... 77 2e-12
UniRef50_A7SZA8 Cluster: Predicted protein; n=4; Nematostella ve... 77 2e-12
UniRef50_Q7NJ82 Cluster: Gll1950 protein; n=2; Gloeobacter viola... 77 2e-12
UniRef50_Q5P4T8 Cluster: Benzoate-CoA ligase; n=42; cellular org... 77 2e-12
UniRef50_Q4ZYG5 Cluster: AMP-dependent synthetase and ligase; n=... 77 2e-12
UniRef50_Q0SA57 Cluster: Long-chain-fatty-acid--CoA ligase; n=8;... 77 2e-12
UniRef50_A7HXR1 Cluster: AMP-dependent synthetase and ligase; n=... 77 2e-12
UniRef50_Q54297 Cluster: Polyketide synthase; n=8; Streptomyces ... 76 3e-12
UniRef50_Q0SEE6 Cluster: Possible long-chain-fatty-acid--CoA lig... 76 3e-12
UniRef50_A3PSP1 Cluster: AMP-dependent synthetase and ligase; n=... 76 3e-12
UniRef50_A0V818 Cluster: AMP-dependent synthetase and ligase; n=... 76 3e-12
UniRef50_Q7NZM4 Cluster: Acyl-CoA synthetase; n=11; Proteobacter... 76 4e-12
UniRef50_Q47YL8 Cluster: Long-chain-fatty-acid--CoA ligase; n=1;... 76 4e-12
UniRef50_Q8RNW9 Cluster: Adenylate-forming enzyme; n=2; Streptom... 76 4e-12
UniRef50_Q2B979 Cluster: Putative long-chain fatty-acid-CoA liga... 76 4e-12
UniRef50_A5V241 Cluster: AMP-dependent synthetase and ligase; n=... 76 4e-12
UniRef50_A4EN20 Cluster: Acetyl-CoA synthetase; n=2; Rhodobacter... 76 4e-12
UniRef50_A3PQM5 Cluster: AMP-dependent synthetase and ligase; n=... 76 4e-12
UniRef50_Q1EC93 Cluster: IP12016p; n=1; Drosophila melanogaster|... 76 4e-12
UniRef50_Q3ARY0 Cluster: Acyl-CoA synthetases (AMP-forming)/AMP-... 75 5e-12
UniRef50_Q1RPI4 Cluster: 2,3-dihydroxybenzoate-AMP ligase; n=31;... 75 5e-12
UniRef50_A6Q2E0 Cluster: Long-chain fatty-acid-CoA ligase; n=8; ... 75 5e-12
UniRef50_A4F0Q0 Cluster: AMP-dependent synthetase and ligase; n=... 75 5e-12
UniRef50_A2U676 Cluster: AMP-dependent synthetase and ligase; n=... 75 5e-12
UniRef50_P46450 Cluster: Long-chain-fatty-acid--CoA ligase; n=25... 75 5e-12
UniRef50_Q06959 Cluster: RfbL protein; n=6; Vibrio cholerae|Rep:... 75 7e-12
UniRef50_Q190Y4 Cluster: AMP-dependent synthetase and ligase; n=... 75 7e-12
UniRef50_A1SPQ8 Cluster: AMP-dependent synthetase and ligase; n=... 75 7e-12
UniRef50_A0HKG0 Cluster: AMP-dependent synthetase and ligase; n=... 75 7e-12
UniRef50_Q97UF6 Cluster: Long-chain-fatty-acid--CoA ligase; n=4;... 75 7e-12
UniRef50_P40871 Cluster: 2,3-dihydroxybenzoate-AMP ligase; n=38;... 75 7e-12
UniRef50_Q3KCL9 Cluster: AMP-dependent synthetase and ligase; n=... 75 9e-12
UniRef50_Q21F78 Cluster: Thioester reductase; n=1; Saccharophagu... 75 9e-12
UniRef50_Q0SDC3 Cluster: Possible long-chain-fatty-acid--CoA lig... 75 9e-12
UniRef50_Q0RKC1 Cluster: Putative Cyclohexanecarboxylate-CoA lig... 75 9e-12
UniRef50_Q0LHV6 Cluster: AMP-dependent synthetase and ligase; n=... 75 9e-12
UniRef50_A3Q403 Cluster: AMP-dependent synthetase and ligase; n=... 75 9e-12
UniRef50_Q5KH65 Cluster: Long-chain-fatty-acid--CoA ligase, puta... 75 9e-12
UniRef50_Q9HSM3 Cluster: Medium-chain acyl-CoA ligase; n=6; Halo... 75 9e-12
UniRef50_UPI0000519DC0 Cluster: PREDICTED: similar to CG6178-PA;... 74 1e-11
UniRef50_Q982I6 Cluster: Peptide synthetase; n=1; Mesorhizobium ... 74 1e-11
UniRef50_Q3EU54 Cluster: Long-chain-fatty-acid--CoA ligase; n=1;... 74 1e-11
UniRef50_Q2HR07 Cluster: Feruloyl-CoA synthetase; n=3; Actinomyc... 74 1e-11
UniRef50_Q0RI70 Cluster: 2,3-dihydroxybenzoate-AMP ligase; n=2; ... 74 1e-11
UniRef50_A5VF80 Cluster: AMP-dependent synthetase and ligase; n=... 74 1e-11
UniRef50_A0Z9L2 Cluster: Coenzyme a synthetase-like protein; n=3... 74 1e-11
UniRef50_Q0YNJ4 Cluster: AMP-dependent synthetase and ligase; n=... 74 2e-11
UniRef50_Q0RXJ7 Cluster: Probable long-chain-fatty-acid--CoA lig... 74 2e-11
UniRef50_Q07P07 Cluster: AMP-dependent synthetase and ligase; n=... 74 2e-11
UniRef50_O54666 Cluster: RifA; n=4; Actinomycetales|Rep: RifA - ... 74 2e-11
UniRef50_O30479 Cluster: PKS module 1; n=2; Streptomyces hygrosc... 74 2e-11
UniRef50_A1SEU0 Cluster: AMP-dependent synthetase and ligase; n=... 74 2e-11
UniRef50_Q01FY3 Cluster: Acyl-CoA synthetase; n=1; Ostreococcus ... 74 2e-11
UniRef50_Q4PD77 Cluster: Putative uncharacterized protein; n=1; ... 74 2e-11
UniRef50_Q89NI2 Cluster: Bll3856 protein; n=2; Bradyrhizobiaceae... 73 2e-11
UniRef50_Q639Z2 Cluster: Long-chain-fatty-acid--CoA ligase; n=3;... 73 2e-11
UniRef50_Q488V3 Cluster: AMP-binding enzyme family protein; n=2;... 73 2e-11
UniRef50_A6UHL1 Cluster: AMP-dependent synthetase and ligase; n=... 73 2e-11
UniRef50_A5WEE0 Cluster: AMP-dependent synthetase and ligase; n=... 73 2e-11
UniRef50_A5UQX5 Cluster: AMP-dependent synthetase and ligase; n=... 73 2e-11
UniRef50_A0TVZ5 Cluster: AMP-dependent synthetase and ligase; n=... 73 2e-11
UniRef50_Q6KZU2 Cluster: Acetoacetyl-CoA synthetase; n=1; Picrop... 73 2e-11
UniRef50_O29570 Cluster: Long-chain-fatty-acid--CoA ligase; n=1;... 73 2e-11
UniRef50_Q5P869 Cluster: 3-hydroxybenzoate CoA ligase; n=2; Rhod... 73 3e-11
UniRef50_Q9KHL1 Cluster: Putative acyl-CoA ligase EncH; n=1; Str... 73 3e-11
UniRef50_Q28S28 Cluster: AMP-dependent synthetase and ligase; n=... 73 3e-11
UniRef50_Q0YL54 Cluster: AMP-dependent synthetase and ligase; n=... 73 3e-11
UniRef50_Q000A6 Cluster: MoeA4; n=7; Actinomycetales|Rep: MoeA4 ... 73 3e-11
UniRef50_A5EXY6 Cluster: Long-chain-fatty-acid--CoA ligase; n=1;... 73 3e-11
UniRef50_A4FF93 Cluster: AMP-dependent synthetase and ligase; n=... 73 3e-11
UniRef50_A3PUH1 Cluster: AMP-dependent synthetase and ligase; n=... 73 3e-11
UniRef50_A1ZCD3 Cluster: Medium-chain-fatty-acid--CoA ligase; n=... 73 3e-11
UniRef50_A1H8X6 Cluster: Medium-chain acyl-CoA ligase; n=5; Bact... 73 3e-11
UniRef50_A0R1V1 Cluster: AMP-dependent synthetase and ligase; n=... 73 3e-11
UniRef50_Q54YU2 Cluster: Putative uncharacterized protein; n=1; ... 73 3e-11
UniRef50_Q9Y8M8 Cluster: Acetyl-coenzyme A synthetase; n=1; Aero... 73 3e-11
UniRef50_Q9A5P7 Cluster: Acid-CoA ligase, putative; n=7; Proteob... 73 4e-11
UniRef50_Q98JP7 Cluster: Probable acid-CoA ligase; n=2; Rhizobia... 73 4e-11
UniRef50_Q7NNH6 Cluster: Glr0435 protein; n=1; Gloeobacter viola... 73 4e-11
UniRef50_Q5NW52 Cluster: DitJ-like CoA ligase (AMP forming), pos... 73 4e-11
UniRef50_Q2NDF4 Cluster: AMP-dependent synthetase and ligase; n=... 73 4e-11
UniRef50_Q24N89 Cluster: Putative uncharacterized protein; n=1; ... 73 4e-11
UniRef50_Q1AUW1 Cluster: AMP-dependent synthetase and ligase; n=... 73 4e-11
UniRef50_Q124C5 Cluster: AMP-dependent synthetase and ligase; n=... 73 4e-11
UniRef50_A3TSX9 Cluster: AMP-dependent synthetase and ligase; n=... 73 4e-11
UniRef50_A1SI84 Cluster: AMP-dependent synthetase and ligase; n=... 73 4e-11
UniRef50_A0PWL4 Cluster: Long-chain-fatty-acid--CoA ligase FadD1... 73 4e-11
UniRef50_Q97VT6 Cluster: Long-chain-fatty-acid--CoA ligase; n=2;... 73 4e-11
UniRef50_Q608C6 Cluster: Putative long-chain fatty-acid-CoA liga... 72 5e-11
UniRef50_Q10878 Cluster: POSSIBLE FATTY-ACID-CoA LIGASE FADD10; ... 72 5e-11
UniRef50_Q70J62 Cluster: Acyl CoA ligase; n=1; Streptomyces gris... 72 5e-11
UniRef50_Q1GTX6 Cluster: AMP-dependent synthetase and ligase; n=... 72 5e-11
UniRef50_Q0G5H5 Cluster: Acyl-CoA synthase; n=1; Fulvimarina pel... 72 5e-11
UniRef50_Q029G6 Cluster: AMP-dependent synthetase and ligase; n=... 72 5e-11
UniRef50_A5UZF0 Cluster: AMP-dependent synthetase and ligase; n=... 72 5e-11
UniRef50_A0QTV8 Cluster: Acyl-CoA synthase; n=3; Corynebacterine... 72 5e-11
UniRef50_A0LU54 Cluster: 3-phosphoshikimate 1-carboxyvinyltransf... 72 5e-11
UniRef50_P94547 Cluster: Long-chain-fatty-acid--CoA ligase; n=26... 72 5e-11
UniRef50_Q9I4X3 Cluster: Probable coenzyme A ligase; n=5; Pseudo... 72 6e-11
UniRef50_Q46S37 Cluster: AMP-dependent synthetase and ligase; n=... 72 6e-11
UniRef50_Q392M0 Cluster: AMP-dependent synthetase and ligase; n=... 72 6e-11
UniRef50_Q9ZGA4 Cluster: FK506 polyketide synthase; n=4; cellula... 72 6e-11
UniRef50_Q1GS96 Cluster: AMP-dependent synthetase and ligase; n=... 72 6e-11
UniRef50_Q13I22 Cluster: Putative AMP-dependent synthetase and l... 72 6e-11
UniRef50_Q0RWB4 Cluster: Long-chain-fatty-acid--CoA ligase; n=5;... 72 6e-11
UniRef50_Q0RF46 Cluster: Putative long-chain-fatty-acid-CoA liga... 72 6e-11
UniRef50_A7DFD6 Cluster: AMP-dependent synthetase and ligase; n=... 72 6e-11
UniRef50_A6T956 Cluster: Putative acyl-CoA synthase; n=1; Klebsi... 72 6e-11
UniRef50_A5WHJ1 Cluster: AMP-dependent synthetase and ligase; n=... 72 6e-11
UniRef50_A3DBZ4 Cluster: AMP-dependent synthetase and ligase; n=... 72 6e-11
UniRef50_A1I8F3 Cluster: Long-chain-fatty-acid--CoA ligase; n=1;... 72 6e-11
UniRef50_A0NHZ6 Cluster: Long-chain acyl-CoA synthetase, ligase;... 72 6e-11
UniRef50_A0HJN0 Cluster: AMP-dependent synthetase and ligase; n=... 72 6e-11
UniRef50_Q89MB1 Cluster: Bll4282 protein; n=1; Bradyrhizobium ja... 71 8e-11
UniRef50_Q2JAS9 Cluster: AMP-dependent synthetase and ligase; n=... 71 8e-11
UniRef50_Q3VZ07 Cluster: AMP-dependent synthetase and ligase; n=... 71 8e-11
UniRef50_Q1GUP2 Cluster: AMP-dependent synthetase and ligase; n=... 71 8e-11
UniRef50_Q1D3K9 Cluster: Non-ribosomal peptide synthase; n=1; My... 71 8e-11
UniRef50_Q13R15 Cluster: Putative long-chain-fatty-acid--CoA lig... 71 8e-11
UniRef50_Q0S7V5 Cluster: CoA ligase; n=21; Bacteria|Rep: CoA lig... 71 8e-11
UniRef50_Q0FLF0 Cluster: Acetyl-CoA synthetase; n=1; Roseovarius... 71 8e-11
UniRef50_Q0AP45 Cluster: AMP-dependent synthetase and ligase; n=... 71 8e-11
UniRef50_A4XY94 Cluster: AMP-dependent synthetase and ligase; n=... 71 8e-11
UniRef50_A4X885 Cluster: AMP-dependent synthetase and ligase; n=... 71 8e-11
UniRef50_A3VLM5 Cluster: Acyl-CoA synthase; n=1; Rhodobacterales... 71 8e-11
UniRef50_A3TSX1 Cluster: Pimeloyl-CoA ligase; n=1; Oceanicola ba... 71 8e-11
UniRef50_A1UD40 Cluster: AMP-dependent synthetase and ligase; n=... 71 8e-11
UniRef50_A0Z815 Cluster: Acyl-CoA synthase; n=2; Gammaproteobact... 71 8e-11
UniRef50_UPI0000D55F1E Cluster: PREDICTED: similar to CG9009-PA;... 71 1e-10
UniRef50_Q9EWP5 Cluster: Putative non-ribosomal peptide synthase... 71 1e-10
UniRef50_Q8D5R8 Cluster: Peptide arylation enzyme; n=6; Vibriona... 71 1e-10
UniRef50_Q6FBY9 Cluster: Putative acyl-CoA ligase; n=1; Acinetob... 71 1e-10
UniRef50_Q9FB23 Cluster: Peptide synthetase NRPS5-4-3; n=1; Stre... 71 1e-10
UniRef50_Q0ASY3 Cluster: AMP-dependent synthetase and ligase; n=... 71 1e-10
UniRef50_A7IDS2 Cluster: AMP-dependent synthetase and ligase; n=... 71 1e-10
UniRef50_A6DB12 Cluster: Acyl-CoA synthase; n=1; Caminibacter me... 71 1e-10
UniRef50_A3RXA3 Cluster: AMP-(Fatty)acid ligases; n=6; Burkholde... 71 1e-10
UniRef50_A1U9T0 Cluster: AMP-dependent synthetase and ligase; n=... 71 1e-10
UniRef50_A0HBU7 Cluster: AMP-dependent synthetase and ligase; n=... 71 1e-10
UniRef50_Q10S72 Cluster: AMP-binding enzyme family protein, expr... 71 1e-10
UniRef50_A7D4R3 Cluster: AMP-dependent synthetase and ligase; n=... 71 1e-10
UniRef50_UPI000159721D Cluster: YdaB; n=1; Bacillus amyloliquefa... 71 1e-10
UniRef50_UPI0001555FCA Cluster: PREDICTED: hypothetical protein,... 71 1e-10
UniRef50_UPI00005F9362 Cluster: COG1021: Peptide arylation enzym... 71 1e-10
UniRef50_Q9CCY8 Cluster: Acyl-CoA synthase; n=14; Mycobacterium|... 71 1e-10
UniRef50_Q987N4 Cluster: Mll6983 protein; n=14; Proteobacteria|R... 71 1e-10
UniRef50_Q8CUP9 Cluster: Long-chain fatty-acid-CoA ligase; n=1; ... 71 1e-10
UniRef50_Q89HA9 Cluster: Blr6085 protein; n=2; Bradyrhizobium|Re... 71 1e-10
UniRef50_Q7WPM7 Cluster: Putative acetyl-CoA synthetase; n=2; Bo... 71 1e-10
UniRef50_Q53005 Cluster: 4-hydroxybenzoate: coenzyme A ligase; n... 71 1e-10
UniRef50_Q39MZ8 Cluster: AMP-dependent synthetase and ligase; n=... 71 1e-10
UniRef50_Q396T0 Cluster: AMP-dependent synthetase and ligase; n=... 71 1e-10
UniRef50_Q2JBC2 Cluster: AMP-dependent synthetase and ligase pre... 71 1e-10
UniRef50_Q2IVI4 Cluster: AMP-dependent synthetase and ligase; n=... 71 1e-10
UniRef50_Q28SY9 Cluster: AMP-dependent synthetase and ligase; n=... 71 1e-10
UniRef50_Q1YTB9 Cluster: Acyl-CoA synthase; n=1; gamma proteobac... 71 1e-10
UniRef50_Q0KAX9 Cluster: Acyl-CoA synthetase (AMP-forming)/AMP-a... 71 1e-10
UniRef50_A5VCX1 Cluster: AMP-dependent synthetase and ligase; n=... 71 1e-10
UniRef50_A4YUD8 Cluster: Putative O-succinylbenzoate--CoA ligase... 71 1e-10
UniRef50_A4VFR2 Cluster: Long-chain-fatty-acid--CoA ligase; n=1;... 71 1e-10
UniRef50_A3TIE6 Cluster: FadD13; n=2; Actinomycetales|Rep: FadD1... 71 1e-10
UniRef50_A3Q5X9 Cluster: AMP-dependent synthetase and ligase; n=... 71 1e-10
UniRef50_A3Q0M6 Cluster: AMP-dependent synthetase and ligase; n=... 71 1e-10
UniRef50_A1WPK7 Cluster: AMP-dependent synthetase and ligase; n=... 71 1e-10
UniRef50_A0NTU6 Cluster: Putative non-ribosomal peptide syntheta... 71 1e-10
UniRef50_A2WY08 Cluster: Putative uncharacterized protein; n=8; ... 71 1e-10
UniRef50_Q4J6S0 Cluster: Medium-chain-fatty-acid-CoA ligase; n=7... 71 1e-10
UniRef50_UPI000051006A Cluster: COG1021: Peptide arylation enzym... 70 2e-10
UniRef50_Q3WCA8 Cluster: AMP-dependent synthetase and ligase; n=... 70 2e-10
UniRef50_Q0IA46 Cluster: Feruloyl-CoA synthetase; n=3; Synechoco... 70 2e-10
UniRef50_A5WEP1 Cluster: AMP-dependent synthetase and ligase; n=... 70 2e-10
UniRef50_A5NRS6 Cluster: AMP-dependent synthetase and ligase; n=... 70 2e-10
>UniRef50_Q9NR19 Cluster: Acetyl-coenzyme A synthetase, cytoplasmic;
n=80; Eukaryota|Rep: Acetyl-coenzyme A synthetase,
cytoplasmic - Homo sapiens (Human)
Length = 701
Score = 580 bits (1433), Expect = e-164
Identities = 260/469 (55%), Positives = 346/469 (73%), Gaps = 15/469 (3%)
Query: 3 SRMYKPTDHVIKKSYLPSIQKYKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNF 62
+R + P V + +++PS+Q+Y+E++ RS+ E FW ++A+EF W P PG F++YNF
Sbjct: 26 ARSWSPPPEVSRSAHVPSLQRYRELHRRSVEEPREFWGDIAKEFYWKT-PCPGPFLRYNF 84
Query: 63 DITKGRVFVKFMEEAELNVCYNLLDRNV-KNGFGDKIAFFWEGNSPDDYTRITYRKLLDL 121
D+TKG++F+++M+ A N+CYN+LDRNV + GDK+AF+WEGN P + T+ITY +LL
Sbjct: 85 DVTKGKIFIEWMKGATTNICYNVLDRNVHEKKLGDKVAFYWEGNEPGETTQITYHQLLVQ 144
Query: 122 VCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLS 181
VCQF+N L +GI+KGDRVA+YMPMI E V+ MLACARIGA+H++VFAGFSS++L ER+
Sbjct: 145 VCQFSNVLRKQGIQKGDRVAIYMPMIPELVVAMLACARIGALHSIVFAGFSSESLCERIL 204
Query: 182 DAKAKLLVTADGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGS-- 239
D+ LL+T D +RGE++ K D+A++K + V C+VV HL R G
Sbjct: 205 DSSCSLLITTDAFYRGEKLVNLKELADEALQKCQEK-GFPVRCCIVVKHLGRAELGMGDS 263
Query: 240 ------LKSEIKDLY-NWNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKP 292
+K D+ +WN+ D+WWHE+++ + C PEW AEDPLF+LYTSGSTGKP
Sbjct: 264 TSQSPPIKRSCPDVQISWNQGIDLWWHELMQEAGDECEPEWCDAEDPLFILYTSGSTGKP 323
Query: 293 KGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFE 352
KGVVHT GY++Y A TF+YVFD+H DV+WCTAD+GWITGH+YV Y PLAN ATSV+FE
Sbjct: 324 KGVVHTVGGYMLYVATTFKYVFDFHAEDVFWCTADIGWITGHSYVTYGPLANGATSVLFE 383
Query: 353 GTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGE 412
G P +P V+R WSI++KYKVT+FYTAPTAIR LM D +T +SL+VLG+VGE
Sbjct: 384 GIPTYPDVNRLWSIVDKYKVTKFYTAPTAIRLLM---KFGDEPVTKHSRASLQVLGTVGE 440
Query: 413 PINPAAWLWYYTRIGKERCSIVDTFWQTETGGHVITGLPGATPMKPGAA 461
PINP AWLWY+ +G +RC IVDTFWQTETGGH++T LPGATPMKPG+A
Sbjct: 441 PINPEAWLWYHRVVGAQRCPIVDTFWQTETGGHMLTPLPGATPMKPGSA 489
Score = 298 bits (732), Expect = 3e-79
Identities = 140/223 (62%), Positives = 164/223 (73%), Gaps = 3/223 (1%)
Query: 486 MIVHLPNKSNRTRG---FPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQ 542
M+ LP + G FPFFGV P ILNE G E+EG EGYLVF +PWPG+MRT+ +
Sbjct: 474 MLTPLPGATPMKPGSATFPFFGVAPAILNESGEELEGEAEGYLVFKQPWPGIMRTVYGNH 533
Query: 543 DRFERVYFSKFPGYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPR 602
+RFE YF KFPGYY TGDG +RD+DGY WITGRIDDMLNVSGHL+STAEVE L
Sbjct: 534 ERFETTYFKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLNVSGHLLSTAEVESALVEHEA 593
Query: 603 VSEAAVVPKPHEVKGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPG 662
V+EAAVV PH VKGE LYCFV L +G F L + L +R+KIG A PD IQNAPG
Sbjct: 594 VAEAAVVGHPHPVKGECLYCFVTLCDGHTFSPKLTEELKKQIREKIGPIATPDYIQNAPG 653
Query: 663 LPKTRSGKIMRRILRKIAVGDHEVGDISTLADPGVVEELFNNR 705
LPKTRSGKIMRR+LRKIA DH++GD+ST+ADP V+ LF++R
Sbjct: 654 LPKTRSGKIMRRVLRKIAQNDHDLGDMSTVADPSVISHLFSHR 696
>UniRef50_Q01L46 Cluster: H0502B11.5 protein; n=5;
Magnoliophyta|Rep: H0502B11.5 protein - Oryza sativa
(Rice)
Length = 747
Score = 476 bits (1174), Expect = e-133
Identities = 223/456 (48%), Positives = 304/456 (66%), Gaps = 17/456 (3%)
Query: 8 PTDHVIKKSYLPSIQKYKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKG 67
P+ ++ + S Q+Y+EMY RS+ + FW+E+A+ F W P N D+TKG
Sbjct: 97 PSADFASQALVSSTQQYQEMYRRSIDDPAGFWSEIAETFYWKHKWNPDEVCTENLDVTKG 156
Query: 68 RVFVKFMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFAN 127
+ +++ + + N+CYN +DRNV+ G G+KIA +WEGN P ++TY +LL+ VCQ AN
Sbjct: 157 PIKIEWFKGGKTNICYNAVDRNVEAGDGEKIAMYWEGNEPGQDAKLTYSELLNKVCQLAN 216
Query: 128 GLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKL 187
L + G+ KGD V +Y+PM++E I MLACARIGAVH+VVFAGFS+DALA+R+ D K K+
Sbjct: 217 YLKSVGVGKGDAVVIYLPMLMELPIAMLACARIGAVHSVVFAGFSADALAQRIIDCKPKV 276
Query: 188 LVTADGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDL 247
++T + RG+++ K D ++ + K+ VD+ + + + ++ ++K E
Sbjct: 277 VITCNAVKRGKKLIALKDIVDVSLADSA---KNGVDVGISLTYENQ----SAMKREDT-- 327
Query: 248 YNWNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAA 307
W D+WW +V+ C EWV AEDPLF+LYTSGSTGKPKGV+HTT GY++Y+A
Sbjct: 328 -KWTSGRDVWWQDVVPNFPTKCDVEWVDAEDPLFLLYTSGSTGKPKGVLHTTGGYMVYSA 386
Query: 308 ATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSII 367
TF++ FDY D+YWCTAD GWITGH+YV Y PL N AT +++EG P +P R W ++
Sbjct: 387 TTFKHAFDYKPSDIYWCTADCGWITGHSYVTYGPLLNGATVLVYEGAPNYPDPGRCWDVV 446
Query: 368 NKYKVTQFYTAPTAIRALMAHYNVEDGN--LTMPDLSSLRVLGSVGEPINPAAWLWYYTR 425
+KY VT FYTAPT IRALM DG +T SLRVLGSVGEPINP AW W+Y
Sbjct: 447 DKYGVTIFYTAPTLIRALM-----RDGTEYVTRYSRKSLRVLGSVGEPINPTAWRWFYDI 501
Query: 426 IGKERCSIVDTFWQTETGGHVITGLPGATPMKPGAA 461
IG RC I DT+WQTETGG +IT LPGA P+KPG+A
Sbjct: 502 IGDARCPISDTWWQTETGGFMITPLPGAWPLKPGSA 537
Score = 252 bits (618), Expect = 2e-65
Identities = 120/203 (59%), Positives = 150/203 (73%), Gaps = 1/203 (0%)
Query: 500 FPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYCT 559
FPFFGV+P I++E G E+EG GYL + WPG RTL D+DR+E YF F GYY +
Sbjct: 539 FPFFGVQPVIVDEKGKEMEGECSGYLCIKKSWPGAFRTLYGDKDRYETTYFKPFAGYYFS 598
Query: 560 GDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEA 619
GDG RD+DGY ++TGR+DD++NVSGH + TAEVE L S P+ +EAAVV HEVKG+
Sbjct: 599 GDGCSRDKDGYHFLTGRVDDVINVSGHRIGTAEVESALVSHPKCAEAAVVGIDHEVKGQG 658
Query: 620 LYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKI 679
+Y FV L +G+ + +L K+L + VR +IGAFAAPD I APGLPKTRSGKIMRRILRKI
Sbjct: 659 IYAFVTLVDGVPYSDELRKSLVMTVRNQIGAFAAPDKIHWAPGLPKTRSGKIMRRILRKI 718
Query: 680 AVGD-HEVGDISTLADPGVVEEL 701
A E+GD STLA+PGVV++L
Sbjct: 719 ASRQLDELGDTSTLAEPGVVDQL 741
>UniRef50_Q89WV5 Cluster: Acetyl-coenzyme A synthetase; n=105;
Bacteria|Rep: Acetyl-coenzyme A synthetase -
Bradyrhizobium japonicum
Length = 648
Score = 456 bits (1125), Expect = e-127
Identities = 225/461 (48%), Positives = 303/461 (65%), Gaps = 27/461 (5%)
Query: 1 MSSRMYKPTDHVIKKSYLPSIQKYKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKY 60
MS ++Y K++++ KYKEMY RS+++ FW E A+ W AP
Sbjct: 1 MSEKIYDVPAEWAKRAWVDQA-KYKEMYARSISDPNGFWAEQAKRIDWMKAPTK----IE 55
Query: 61 NFDITKGRVFVKFMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLD 120
N G V +K+ E+ LNV +N +DR++ ++ A WEG+ P ITY++L D
Sbjct: 56 NVSFAPGNVSIKWFEDGVLNVAHNCIDRHLHKR-ANQTAIIWEGDDPSQSRHITYKELHD 114
Query: 121 LVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERL 180
VC+ AN L + ++KGDRV +Y+PMI EA MLACARIGA+H+VVFAGFS D+LA+R+
Sbjct: 115 EVCRMANILRTRNVKKGDRVTIYLPMIPEAAYAMLACARIGAIHSVVFAGFSPDSLAQRI 174
Query: 181 SDAKAKLLVTADGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSL 240
+D ++K+++TAD RG + K D A+ KA VD +VV GG +
Sbjct: 175 NDCQSKVIITADEGLRGGKKVPLKANVDAALAKA-----DGVDWVVVVKRT-----GGKI 224
Query: 241 KSEIKDLYNWNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTA 300
+ N D+W+HE + CP E + AEDPLF+LYTSGSTG+PKGV+HT+A
Sbjct: 225 --------DMNPTRDLWYHEAAAMVTTECPVEHMHAEDPLFILYTSGSTGQPKGVLHTSA 276
Query: 301 GYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKV 360
GYL+YAA T +YVFDYH D+YWCTADVGW+TGH+Y++Y PLAN AT++MFEG P +P
Sbjct: 277 GYLVYAAMTHQYVFDYHDGDIYWCTADVGWVTGHSYILYGPLANGATTLMFEGVPNYPDN 336
Query: 361 DRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWL 420
R+W++I+K+KV FYTAPTAIRALM D + +SLR+LGSVGEPINP AW
Sbjct: 337 SRFWNVIDKHKVNTFYTAPTAIRALM---QGGDEPVKKTSRASLRLLGSVGEPINPEAWE 393
Query: 421 WYYTRIGKERCSIVDTFWQTETGGHVITGLPGATPMKPGAA 461
WY+ +G++RC IVDT+WQTETGG +IT LPGAT +KPG+A
Sbjct: 394 WYHRVVGEDRCPIVDTWWQTETGGILITPLPGATKLKPGSA 434
Score = 252 bits (616), Expect = 3e-65
Identities = 126/225 (56%), Positives = 154/225 (68%), Gaps = 4/225 (1%)
Query: 485 VMIVHLPNKSNRTRGF---PFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLED 541
++I LP + G PFFGV P+I++ DG +EG G L R WPGMMRT+ D
Sbjct: 418 ILITPLPGATKLKPGSATQPFFGVVPEIVDADGKVLEGETTGNLCLTRAWPGMMRTVYGD 477
Query: 542 QDRFERVYFSKFPGYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDP 601
RFE+ YFS + G Y TGDG RRD DGY WITGR+DD++NVSGH M TAEVE L +
Sbjct: 478 HARFEQTYFSTYKGKYFTGDGCRRDADGYYWITGRVDDVINVSGHRMGTAEVESALVAHE 537
Query: 602 RVSEAAVVPKPHEVKGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAP 661
+VSEAAVV PH++KG+ +Y +V L G+Q DL K L VR++IG A+PD IQ AP
Sbjct: 538 KVSEAAVVGFPHDIKGQGIYAYVTLMAGVQPTEDLRKELVTWVRKEIGPIASPDQIQFAP 597
Query: 662 GLPKTRSGKIMRRILRKIAVGD-HEVGDISTLADPGVVEELFNNR 705
GLPKTRSGKIMRRILRKIA + +GD STLADP VV++L NR
Sbjct: 598 GLPKTRSGKIMRRILRKIAEDEPGSLGDTSTLADPAVVDDLVKNR 642
>UniRef50_Q8YJ48 Cluster: Acetyl-coenzyme A synthetase; n=48;
cellular organisms|Rep: Acetyl-coenzyme A synthetase -
Brucella melitensis
Length = 651
Score = 450 bits (1109), Expect = e-125
Identities = 225/463 (48%), Positives = 301/463 (65%), Gaps = 24/463 (5%)
Query: 1 MSSRMYKPTDHVIKKSYLPSIQKYKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKY 60
MS ++Y P KK+ L + Y E YE S+++ + FW + + W KP F K
Sbjct: 1 MSEKLY-PVLPEAKKNTLIDNETYLEWYEESVSDPDGFWAKHGRRIDWF---KP--FTKV 54
Query: 61 NFDITKGRVFVKFMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLD 120
G V +K+ E+ NV YN +DR++K+ GDK+A WEG++P +ITYR+L +
Sbjct: 55 KNTDFNGDVTIKWYEDGVTNVSYNCIDRHLKSR-GDKVAIIWEGDNPYIDKKITYRELYE 113
Query: 121 LVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERL 180
VC+ AN L G++KGDRV +Y+PMI EA MLACARIGAVH+VVFAGFS +ALA R+
Sbjct: 114 NVCRMANVLKKHGVKKGDRVTIYLPMIPEAAYAMLACARIGAVHSVVFAGFSPEALAGRI 173
Query: 181 SDAKAKLLVTADGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSL 240
D ++ ++TAD RG + K D AI+ A + V+ +VV GG +
Sbjct: 174 VDCESTFVITADEGVRGGKPVALKENTDTAIDIAAKQYV-MVNKVLVVRRT-----GGKV 227
Query: 241 KSEIKDLYNWNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTA 300
+W D+W+H+ + C PE + AEDPLF+LYTSGSTGKPKGV+HTT
Sbjct: 228 --------SWGRGRDLWYHQEVASVEPHCEPEPMNAEDPLFILYTSGSTGKPKGVLHTTG 279
Query: 301 GYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKV 360
GYL+YA+ T +YVFDYH ++YWCTADVGW+TGH+Y+VY PLAN AT++MFEG P FP
Sbjct: 280 GYLVYASMTHQYVFDYHDGEIYWCTADVGWVTGHSYIVYGPLANGATTLMFEGVPNFPDQ 339
Query: 361 DRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWL 420
R+W +++K+ V FYTAPTA+RALM D +T S+LR+LGSVGEPINP AW
Sbjct: 340 GRFWEVVDKHHVNIFYTAPTALRALM---GAGDEFVTRSSRSTLRLLGSVGEPINPEAWE 396
Query: 421 WYYTRIGKERCSIVDTFWQTETGGHVITGLPGATPMKPGAAEK 463
WYY +G ++C IVDT+WQTE GG +IT LPGAT +KPG+A +
Sbjct: 397 WYYNVVGDQKCPIVDTWWQTENGGILITPLPGATDLKPGSATR 439
Score = 234 bits (573), Expect = 5e-60
Identities = 120/227 (52%), Positives = 150/227 (66%), Gaps = 6/227 (2%)
Query: 485 VMIVHLPNKSNRTRGF---PFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLED 541
++I LP ++ G PFFGV+P +++ +G EG +G L + WPG MRT+ D
Sbjct: 421 ILITPLPGATDLKPGSATRPFFGVKPVLVDNEGNVQEGVADGNLCISDSWPGQMRTVYGD 480
Query: 542 QDRFERVYFSKFPGYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDP 601
RF YFS + G Y +GDG RRDEDGY WITGR+DD+LN+SGH + TAE+E L S
Sbjct: 481 HKRFIETYFSTYKGMYFSGDGCRRDEDGYYWITGRVDDVLNISGHRLGTAEIESALVSHH 540
Query: 602 RVSEAAVVPKPHEVKGEALYCFVVLKEG--LQFDADLVKTLTLLVRQKIGAFAAPDTIQN 659
VSEAAVV PH +KG+ +YC+V L G Q +L K L VR++IG A PD IQ
Sbjct: 541 SVSEAAVVGYPHPIKGQGIYCYVTLMTGADAQDPDELRKELVQHVRKEIGPIATPDKIQF 600
Query: 660 APGLPKTRSGKIMRRILRKIAVGDH-EVGDISTLADPGVVEELFNNR 705
APGLPKTRSGKIMRRILRKIA + +GD STLAD GVV++L NR
Sbjct: 601 APGLPKTRSGKIMRRILRKIAEDEFGALGDTSTLADRGVVDDLIENR 647
>UniRef50_Q4QBC0 Cluster: Acetyl-CoA synthetase, putative; n=6;
Eukaryota|Rep: Acetyl-CoA synthetase, putative -
Leishmania major
Length = 705
Score = 426 bits (1049), Expect = e-117
Identities = 216/467 (46%), Positives = 296/467 (63%), Gaps = 26/467 (5%)
Query: 3 SRMYKPTDHVIKKSYL-PSIQKYKEMYERSLTESELFWTEVAQ-EFQWHVA-PKPGGFMK 59
+ + +PT+ KS++ P + +YE S+ +++FW E+A+ +F W P
Sbjct: 41 TNVVEPTEANRTKSHVGPHLGSRMRIYEYSIEHNDVFWAEIARRDFYWKTTWPDDQHVKS 100
Query: 60 YNFDITKGRVFVKFMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLL 119
YNFD +KG +FVK+ E A N+CYN LDR++ D++ F++EGN P ++TY +
Sbjct: 101 YNFDKSKGPIFVKWFEGAVTNICYNALDRHLP-AHKDRVCFYFEGNDPSVTEKVTYGSMY 159
Query: 120 DLVCQFANGLLAK-GIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAE 178
V + AN L + GI KGDRV +Y+PMI A + MLACARIGAV TV+F GFS+ AL+
Sbjct: 160 TRVVELANVLKHQYGITKGDRVGLYLPMIPFAAVAMLACARIGAVITVIFGGFSAQALSS 219
Query: 179 RLSDAKAKLLVTADGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGG 238
RL DA+AKLL+TAD + RG + + K D+A++ + C+V +++R
Sbjct: 220 RLKDAQAKLLITADASARGTKPILLKDMADEALKVCEE--EGMSIACLVFENMNR----- 272
Query: 239 SLKSEIKDLYNWNEETDIWWHEVLEG----ESNICPPEWVAAEDPLFVLYTSGSTGKPKG 294
E D W+ + L + CP EW+ AED LF+LYTSGSTGKPK
Sbjct: 273 -------QFCKMKEGRDTWYGDALARLTPEQHEECPVEWMDAEDVLFLLYTSGSTGKPKA 325
Query: 295 VVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGT 354
+VHTTAGY++YA+ TF Y FDYH DVY+CTAD+GWITGH+YVVY P+ + ATSV+FEG
Sbjct: 326 IVHTTAGYMVYASTTFMYSFDYHMDDVYFCTADIGWITGHSYVVYGPMIHCATSVLFEGV 385
Query: 355 PYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPI 414
+P R+W ++ KYKV+ YTAPTAIR+LM D + + + S+LRVLGSVGEPI
Sbjct: 386 ANYPDYSRWWQLVEKYKVSILYTAPTAIRSLM---QAGDDYVKVGNRSTLRVLGSVGEPI 442
Query: 415 NPAAWLWYYTRIGKERCSIVDTFWQTETGGHVITGLPGATPMKPGAA 461
N AW W G+ C + DT+WQTETGGH+IT +PG TPMKPG+A
Sbjct: 443 NVEAWKWLRDVGGEGHCDVSDTWWQTETGGHMITPMPGCTPMKPGSA 489
Score = 220 bits (538), Expect = 9e-56
Identities = 108/204 (52%), Positives = 140/204 (68%), Gaps = 4/204 (1%)
Query: 501 PFFGVEPKILNEDGV-EIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYCT 559
PFFGV+P IL+ + E +GP EG L PWPGM RT+ D RFE+ YF GYY T
Sbjct: 492 PFFGVQPVILDPMKLNEKQGPAEGLLAIRAPWPGMARTIYGDHARFEKTYFD-VDGYYMT 550
Query: 560 GDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEA 619
GDG RRD DGY WITGR+DD+LNVSGH + T+E+E + + P V E+AVV PH +KGE
Sbjct: 551 GDGARRDSDGYYWITGRVDDVLNVSGHRIGTSEIEDAVNTHPAVVESAVVGFPHNIKGEG 610
Query: 620 LYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNA-PGLPKTRSGKIMRRILRK 678
+Y F+ ++G + +L+ + VR+ IG A PD +Q A GLPKTRSGKI+RRILRK
Sbjct: 611 IYVFLTFRQGTEVTPELLAAVKATVRKVIGPLATPDVMQVARVGLPKTRSGKIVRRILRK 670
Query: 679 IAVGDHE-VGDISTLADPGVVEEL 701
++ G + +GD STLA+P VVE+L
Sbjct: 671 VSSGQYTGLGDTSTLANPDVVEDL 694
>UniRef50_Q8EYG2 Cluster: Acetyl-coenzyme A synthetase; n=76;
cellular organisms|Rep: Acetyl-coenzyme A synthetase -
Leptospira interrogans
Length = 661
Score = 424 bits (1045), Expect = e-117
Identities = 216/450 (48%), Positives = 281/450 (62%), Gaps = 26/450 (5%)
Query: 14 KKSYLPSIQKYKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRVFVKF 73
KK+ S++ YK +Y+ S+ FW A W K + ++F K V++
Sbjct: 21 KKNANISLKNYKSLYKESIENPNKFWAREANRLIWF--KKWTKVLSHDFKNAK----VEW 74
Query: 74 MEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKG 133
+ +LNV YN LDR++ +K A WEG++P + +TY + V +FAN L G
Sbjct: 75 FKGGKLNVSYNCLDRHISTPLKNKAALIWEGDNPTESRVLTYYDVYREVNRFANILKKFG 134
Query: 134 IRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADG 193
++KGDRV VY+PMI E I +LAC RIGA+H+VVF GFS +AL R+ D K KL+VTADG
Sbjct: 135 VKKGDRVLVYLPMIPELAITILACTRIGAIHSVVFGGFSPEALQSRIDDCKPKLVVTADG 194
Query: 194 AWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEE 253
+RG + K+ D A+EK+ K +V +VV + W +
Sbjct: 195 GFRGGKPIELKKNVDLALEKS----KEKVKTVIVVRRTGNESG-----------LTWKDG 239
Query: 254 TDIWWHEVLEGE--SNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFR 311
D W+H ++ S C PE + AEDPLF+LYTSGSTGKPKGV+HTT GYL+ A TF
Sbjct: 240 QDYWYHFLMNDPELSAYCKPEEMDAEDPLFILYTSGSTGKPKGVLHTTGGYLLGANLTFH 299
Query: 312 YVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYK 371
YVFD D YWCTAD+GW+TGH+Y+VY PL+N A+SVMFEG P +P R+W +I+KY
Sbjct: 300 YVFDIKPEDTYWCTADIGWVTGHSYLVYGPLSNGASSVMFEGVPSYPDAGRFWDVIDKYG 359
Query: 372 VTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERC 431
V FYTAPTAIRALM ++ DLSSLR+LGSVGEPINP AW WY+ IGK +C
Sbjct: 360 VNIFYTAPTAIRALMRE---GLNHIQKRDLSSLRLLGSVGEPINPEAWEWYFKNIGKGKC 416
Query: 432 SIVDTFWQTETGGHVITGLPGATPMKPGAA 461
IVDT+WQTETG +IT LPGA P KPG+A
Sbjct: 417 PIVDTWWQTETGSIMITALPGAIPQKPGSA 446
Score = 239 bits (584), Expect = 2e-61
Identities = 120/228 (52%), Positives = 152/228 (66%), Gaps = 6/228 (2%)
Query: 484 TVMIVHLPNKSNRTRG---FPFFGVEPKILNEDGVEIEGPGE--GYLVFARPWPGMMRTL 538
++MI LP + G PFFGV+P +++ DG EI GE G L PWP MMR +
Sbjct: 429 SIMITALPGAIPQKPGSATLPFFGVQPVLVDNDGKEITDKGEVSGNLCIKGPWPSMMRGV 488
Query: 539 LEDQDRFERVYFSKFPGYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLA 598
D RF YFS+F GYY TGDG RRD+DGY WITGR+DD++NVSGH + +AEVE L
Sbjct: 489 YGDPKRFFETYFSQFKGYYFTGDGARRDKDGYFWITGRVDDVINVSGHRIGSAEVESALV 548
Query: 599 SDPRVSEAAVVPKPHEVKGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQ 658
+ V+EAAVV PH++KG+ +Y +V +KEG+ + L K L V + IG A PD I
Sbjct: 549 ENKSVAEAAVVGFPHDIKGQGIYAYVTVKEGVTTNDVLKKELISTVEKMIGKIARPDVIH 608
Query: 659 NAPGLPKTRSGKIMRRILRKIAVGDHE-VGDISTLADPGVVEELFNNR 705
APGLPKTRSGKIMRRILRKI G+ E +GD STLADP VV++L ++
Sbjct: 609 WAPGLPKTRSGKIMRRILRKIVSGEFEGLGDTSTLADPSVVQKLIEDK 656
>UniRef50_Q55404 Cluster: Acetyl-coenzyme A synthetase; n=89;
cellular organisms|Rep: Acetyl-coenzyme A synthetase -
Synechocystis sp. (strain PCC 6803)
Length = 653
Score = 421 bits (1036), Expect = e-116
Identities = 216/464 (46%), Positives = 293/464 (63%), Gaps = 30/464 (6%)
Query: 4 RMYKPTDHVIKKSYLPSIQKYKEMYERSLTESELFWTEVA-QEFQWHVAPKPGGFMKYNF 62
R++ P +++Y+ S ++Y+++Y R+ + E FW E+A QE W F K++
Sbjct: 13 RLFDPPTEFSERAYVRSGREYEQLYSRAASNPEKFWGELAEQELHW--------FKKWDQ 64
Query: 63 DITKGRVFVKFMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLV 122
+ F K+ +LN+ +N LDR++ +K A WEG P D ITY +L V
Sbjct: 65 VLDWQPPFAKWFVGGQLNISHNCLDRHLTTWRRNKAAIIWEGE-PGDSRIITYAQLHREV 123
Query: 123 CQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSD 182
CQFAN L + G++KGDRVA+Y+PMI EA I MLAC+RIGA H+VVF GFS++AL +RL D
Sbjct: 124 CQFANALKSLGVQKGDRVAIYLPMIPEAAITMLACSRIGAPHSVVFGGFSAEALRDRLVD 183
Query: 183 AKAKLLVTADGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKS 242
A+AKL++TADG +R ++ K+ D A+E V+ +VV K+
Sbjct: 184 AEAKLVITADGGFRKDKAIALKQEVDKALEHGAP----SVENVIVVQRT---------KA 230
Query: 243 EIKDLYNWNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGY 302
++ D WWHE+ +S CP E + +ED LF+LYTSGSTGKPKGVVHTT GY
Sbjct: 231 DV----TMTAGRDHWWHELQPQQSAHCPAEPIDSEDMLFILYTSGSTGKPKGVVHTTGGY 286
Query: 303 LMYAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDR 362
+Y T +++FD DVYWCTADVGWITGH+Y+VY PL+N AT+VM+EG P
Sbjct: 287 NLYTHMTTKWIFDLKDTDVYWCTADVGWITGHSYIVYGPLSNGATTVMYEGVPRPSNPGC 346
Query: 363 YWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWY 422
+W +I +Y V FYTAPTAIRA + + + DLSSLR+LG+VGEPINP AW+WY
Sbjct: 347 FWDVIERYGVNIFYTAPTAIRAFI---RMGEAVPNARDLSSLRLLGTVGEPINPEAWMWY 403
Query: 423 YTRIGKERCSIVDTFWQTETGGHVITGLPGATPMKPGAAEKKHP 466
+ IG +C IVDT+WQTETGG ++T LPGA P KPG+ K P
Sbjct: 404 HRVIGGGKCPIVDTWWQTETGGIMLTPLPGAIPTKPGSCTKPFP 447
Score = 186 bits (454), Expect = 1e-45
Identities = 96/206 (46%), Positives = 129/206 (62%), Gaps = 5/206 (2%)
Query: 501 PFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFS----KFPGY 556
PF G+ +I++ DG +E G+LV +PWP M+R + D DRF Y+ K Y
Sbjct: 445 PFPGIVAEIVDLDGNPVESDQGGFLVIKQPWPSMIRDVYGDTDRFRHTYWEHIQPKEGQY 504
Query: 557 -YCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEV 615
Y GDG RRD+DGY W+ GR+DD++NVSGH + T E+E L S P V+EAAVV +P E+
Sbjct: 505 LYFAGDGARRDKDGYFWVMGRVDDVINVSGHRLGTMEIESALVSHPLVAEAAVVGRPDEL 564
Query: 616 KGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRI 675
GEA++ FV L+ + +L K L V ++IGA A P I+ LPKTRSGKIMRR+
Sbjct: 565 TGEAIFAFVSLEGNAEPSEELKKDLVKHVTEEIGAIARPAEIRFTDVLPKTRSGKIMRRL 624
Query: 676 LRKIAVGDHEVGDISTLADPGVVEEL 701
LR +A G GD STL D V+++L
Sbjct: 625 LRSLASGQEISGDTSTLEDRTVLDKL 650
>UniRef50_Q01CP6 Cluster: Acyl-CoA synthetase; n=6; Eukaryota|Rep:
Acyl-CoA synthetase - Ostreococcus tauri
Length = 744
Score = 414 bits (1019), Expect = e-114
Identities = 201/464 (43%), Positives = 300/464 (64%), Gaps = 15/464 (3%)
Query: 7 KPTDHVIKKSYLPSIQKYKEMYERSLTESELFWTEVAQEFQWHVA----PKPGGFMKYNF 62
+P + ++++ S+++Y+ MY RS+ E E+FW+E+A E +W A KP +++NF
Sbjct: 68 EPPMELAARAHVGSMEQYRSMYNRSIKEPEMFWSEIAGELRWETAFDGVDKPEEVLEWNF 127
Query: 63 DITKGRVFVKFMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLV 122
D +KG V+VK+ N+ +N LD ++ G GD A +E N + T+ +L + V
Sbjct: 128 DPSKGEVYVKWFAGGRTNMSFNCLDLQIERGLGDSPALIFEANDAVNSRIFTFNELREEV 187
Query: 123 CQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSD 182
F+ L+A+GI KGDRV +Y+PMI I MLACARIGAVH++VFAG+S+ +LA+R+ D
Sbjct: 188 STFSKFLVAQGIGKGDRVIMYLPMIPMMPIAMLACARIGAVHSIVFAGYSAKSLAQRVVD 247
Query: 183 AKAKLLVTADGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLD-RVTPGGSLK 241
+AK+++TA + RG+++ K+ D+A+E D +V + D R+ L
Sbjct: 248 CQAKMIITASASRRGKKIIPLKKIVDEALEICMQNDGFSPDRVVVKGNADTRIDDTPFL- 306
Query: 242 SEIKDLYNWNEETDIWWHEVLEG---ESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHT 298
I D+ +N + D+WW + + + P E++ + DP F+LYTSGSTGKPKGVVH
Sbjct: 307 -NIDDV-PFNPQRDLWWDDDISQYRMDEKPDPMEFIDSLDPAFILYTSGSTGKPKGVVHA 364
Query: 299 TAGYLMYAAATFRYVFDYH-RRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYF 357
GYL+YA AT ++VFD H D+ +CTAD+GWITGH+Y +Y PL N +V+FEGTP +
Sbjct: 365 LGGYLVYAYATSKFVFDLHPGEDIVFCTADLGWITGHSYTLYGPLLNGCATVLFEGTPTY 424
Query: 358 PKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPA 417
P + +W+I++K++VT FYT+PTA+R L D + ++LR+LG+VGEPI
Sbjct: 425 PNAEIWWNIVDKHRVTIFYTSPTALRTLQ---GFGDAPVHKSSRATLRILGTVGEPIAKE 481
Query: 418 AWLWYYTRIGKERCSIVDTFWQTETGGHVITGLPGATPMKPGAA 461
WLWY+ IG ++ IVDT+WQTETGGH+IT LPGATP+KP +A
Sbjct: 482 TWLWYHEIIGDKKLPIVDTWWQTETGGHIITPLPGATPLKPSSA 525
Score = 212 bits (517), Expect = 3e-53
Identities = 110/208 (52%), Positives = 138/208 (66%), Gaps = 11/208 (5%)
Query: 500 FPFFGVEPKILNE-DGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPG-YY 557
FPFFGVEP +L+ DG EI+G GEG L RPWPG+ + +R+E YF F G YY
Sbjct: 527 FPFFGVEPVLLDPVDGHEIDGEGEGSLCIKRPWPGIFMDVHGAHERYENSYFKVFEGGYY 586
Query: 558 CTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKG 617
+GDG RRD DGYL++TGR+DD++NVSGH + TAEVE L P EAAVV HE+KG
Sbjct: 587 ASGDGARRDADGYLYVTGRLDDVMNVSGHRIGTAEVESALVQHPLCIEAAVVSIGHEIKG 646
Query: 618 EALYCFVVL-----KEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIM 672
E + FV+L KE Q+ + L VR +IG FAAP+ + LPKTRSGKIM
Sbjct: 647 ETIVAFVILDPLRKKEATQYPE---QELVFKVRAEIGPFAAPERVIVVKNLPKTRSGKIM 703
Query: 673 RRILRKIAVGD-HEVGDISTLADPGVVE 699
RRIL+KIA G+ ++GD+S LADPG +E
Sbjct: 704 RRILKKIAAGNIEDLGDVSALADPGSIE 731
>UniRef50_Q82EL5 Cluster: Acetyl-coenzyme A synthetase; n=28;
cellular organisms|Rep: Acetyl-coenzyme A synthetase -
Streptomyces avermitilis
Length = 652
Score = 411 bits (1011), Expect = e-113
Identities = 213/442 (48%), Positives = 276/442 (62%), Gaps = 30/442 (6%)
Query: 26 EMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRVFVKFMEEAELNVCYNL 85
E YE++ + FW E A+ W A +P + ++ F K+ ++ +LNV YN
Sbjct: 31 EAYEQAKADRLGFWAEQARRLTW--ATEPTETLDWS-----NPPFAKWFKDGKLNVAYNC 83
Query: 86 LDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMP 145
+DR+V+ G GD++A +EG P D ITY +L D V + AN L G++KGDRVAVY+P
Sbjct: 84 VDRHVEAGHGDRVAIHFEGE-PGDSRAITYAELKDEVSKAANALTELGVQKGDRVAVYLP 142
Query: 146 MILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGERMYVYKR 205
MI EAV+ MLACARIGA H+VVF GFS+DA+A R+ DA AKL++TADG +R + K
Sbjct: 143 MIPEAVVAMLACARIGAAHSVVFGGFSADAIAARIKDADAKLVITADGGYRRGKPSALKP 202
Query: 206 TCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIWWHEVLEGE 265
DDA+ + V+ +VV + E+ W E D+WWHE+ +
Sbjct: 203 AVDDAVSRG-----DGVEKVLVVRRTGQ---------EVA----WTEGRDVWWHEITAKQ 244
Query: 266 SNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYH-RRDVYWC 324
S PE AE PLF+LYTSG+TGKPKG++HT+ GYL + T VFD DVYWC
Sbjct: 245 SAEHTPEAFDAEHPLFILYTSGTTGKPKGILHTSGGYLTQTSYTHHAVFDLKPETDVYWC 304
Query: 325 TADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRA 384
TAD+GW+TGH+Y+ Y PL+N AT VM+EGTP P R+W I+ KY VT YTAPTAIR
Sbjct: 305 TADIGWVTGHSYITYGPLSNGATQVMYEGTPDTPHQGRFWEIVQKYGVTILYTAPTAIRT 364
Query: 385 LMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTETGG 444
M D DLSSLRVLGSVGEPINP AW+WY IG +R IVDT+WQTETG
Sbjct: 365 FM---KWGDDIPAKFDLSSLRVLGSVGEPINPEAWIWYRKHIGGDRTPIVDTWWQTETGA 421
Query: 445 HVITGLPGATPMKPGAAEKKHP 466
+I+ LPG T KPG+A++ P
Sbjct: 422 MMISPLPGVTETKPGSAQRPLP 443
Score = 178 bits (433), Expect = 5e-43
Identities = 95/227 (41%), Positives = 133/227 (58%), Gaps = 5/227 (2%)
Query: 485 VMIVHLPNKSNRTRGF---PFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLED 541
+MI LP + G P G+ +++++ E+ G GYLV PWP M+RT+ D
Sbjct: 422 MMISPLPGVTETKPGSAQRPLPGISATVVDDEAREVPNGGGGYLVLTEPWPSMLRTIWGD 481
Query: 542 QDRFERVYFSKFPGYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDP 601
RF Y+S+F G Y GDG ++DEDG +W+ GR+DD++ VSGH +ST EVE L S P
Sbjct: 482 DQRFLDTYWSRFEGKYFAGDGAKKDEDGDIWLLGRVDDVMLVSGHNISTTEVESALVSHP 541
Query: 602 RVSEAAVVPKPHEVKGEALYCFVVLKEGLQFDAD-LVKTLTLLVRQKIGAFAAPDTIQNA 660
V+EAAVV E G+A+ FV+L+ + D LV L V +G A P I
Sbjct: 542 SVAEAAVVGAADETTGQAIVAFVILRGTANAEDDNLVADLRNHVGTTLGPIAKPKRILPV 601
Query: 661 PGLPKTRSGKIMRRILRKIAVGDHEVGDISTLADPGVVEELFNNRPA 707
LPKTRSGKIMRR+LR +A + +GD++TL D V++ + + PA
Sbjct: 602 AELPKTRSGKIMRRLLRDVA-ENRALGDVTTLTDSSVMDLIQSKLPA 647
>UniRef50_Q8KBY0 Cluster: Acetyl-coenzyme A synthetase; n=44;
cellular organisms|Rep: Acetyl-coenzyme A synthetase -
Chlorobium tepidum
Length = 659
Score = 409 bits (1006), Expect = e-112
Identities = 199/463 (42%), Positives = 297/463 (64%), Gaps = 30/463 (6%)
Query: 4 RMYKPTDHVIKKSYLPSIQKYKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFD 63
R + P + +S++ S+++Y+++Y + + + +W ++A++F W F K++
Sbjct: 22 RKFPPPEAFSSQSHISSMEQYEKLYADAAADPDKYWGDLAEQFHW--------FKKWDSV 73
Query: 64 ITKGRVFVKFMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVC 123
+ + K+ N+ YN LD +V + +K A WEG ++ +TY +L V
Sbjct: 74 LEWNAPYAKWFNGGTTNIAYNCLDVHVGSWRKNKAAIIWEGEEGNERI-LTYGELHRQVS 132
Query: 124 QFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDA 183
+FAN L GI+ GD+VA+YM M+ E VI +LACAR+GAVH V+FAGF++ A+ ER++D+
Sbjct: 133 KFANVLKIAGIKPGDKVAIYMGMVPELVIAVLACARVGAVHNVIFAGFAAHAITERVNDS 192
Query: 184 KAKLLVTADGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSE 243
+AK+++ ADG R K D+AI ++ V N + G +
Sbjct: 193 RAKIVICADGTRRRGSTINLKNIVDEAI----------INTPSVKNVIVLKVTGEEI--- 239
Query: 244 IKDLYNWNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYL 303
+ ++ D WWH+++ + C P V +E PLF+LYTSGSTGKPKG++HTTAGY+
Sbjct: 240 -----HMHDGMDHWWHDLMGLAVDECEPAQVDSEHPLFLLYTSGSTGKPKGILHTTAGYM 294
Query: 304 MYAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRY 363
++AA++F+YVFD D+Y+CTAD+GWITGHTY++Y PL N AT M+EG P +P+ DR+
Sbjct: 295 VHAASSFKYVFDIKDEDIYFCTADIGWITGHTYIIYGPLLNGATVFMYEGAPNYPQWDRF 354
Query: 364 WSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYY 423
W IIN++K+T YTAPTAIRA + N +T DLSSLR+LG+VGEPINP AW+WY+
Sbjct: 355 WDIINRHKITILYTAPTAIRAFIRAGNEW---VTKHDLSSLRLLGTVGEPINPEAWMWYH 411
Query: 424 TRIGKERCSIVDTFWQTETGGHVITGLPGATPMKPGAAEKKHP 466
+G+E+C IVDT+WQTETGG +I+ +PGATP KPG A + P
Sbjct: 412 KYVGQEKCPIVDTWWQTETGGIMISPMPGATPTKPGTATRPLP 454
Score = 226 bits (552), Expect = 2e-57
Identities = 105/201 (52%), Positives = 140/201 (69%)
Query: 501 PFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYCTG 560
P G+ ++ +DG GYLV RPWP M+RT+ D +R+E+ Y+S+FPG Y TG
Sbjct: 452 PLPGIMVDVVRKDGTPCNANEGGYLVVKRPWPSMLRTIYGDNERYEKTYWSEFPGMYFTG 511
Query: 561 DGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEAL 620
DG R+D+DGY+WI GR+DD++NVSGH + T+EVE L S V+EAAVV +P E+KG AL
Sbjct: 512 DGARKDDDGYIWIMGRVDDVVNVSGHRLGTSEVESALVSHEAVAEAAVVSRPDEIKGNAL 571
Query: 621 YCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKIA 680
FV LK+G + DA L +L V ++IGA A PD I+ A GLPKTRSGKIMRR+LR++A
Sbjct: 572 VAFVTLKDGYEGDAKLRDSLGKHVAKEIGAIAKPDEIRWAKGLPKTRSGKIMRRLLRELA 631
Query: 681 VGDHEVGDISTLADPGVVEEL 701
+ GD++TL D GV+E L
Sbjct: 632 TSNEIKGDVTTLEDLGVIENL 652
>UniRef50_O67872 Cluster: Acetyl-coenzyme A synthetase; n=5;
cellular organisms|Rep: Acetyl-coenzyme A synthetase -
Aquifex aeolicus
Length = 510
Score = 404 bits (994), Expect = e-111
Identities = 213/458 (46%), Positives = 295/458 (64%), Gaps = 34/458 (7%)
Query: 6 YKPTDHVIKKSYLPSIQKYKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDIT 65
Y P ++++++ I+ Y+++YE S+ + E FW +VA+E W K +++NF
Sbjct: 16 YYPPKEIVERAW---IKDYEKVYEESIKDREGFWAKVAEELHWF--KKWDKVLEWNFP-- 68
Query: 66 KGRVFVKFMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQF 125
+ K+ A+ N+ YN LDR+V+NG +K+A+ + + D+ +ITY +LL+LV +
Sbjct: 69 ----YAKWFVGAKTNITYNCLDRHVQNGKRNKVAYIYVDEN-DNEKKITYGELLELVNRI 123
Query: 126 ANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKA 185
ANGL + G++KGDRV++YMP +EA+ MLACARIGA+H+VVFAGFS AL R+ DAKA
Sbjct: 124 ANGLKSLGVKKGDRVSIYMPTTIEAIATMLACARIGAIHSVVFAGFSEGALRTRIEDAKA 183
Query: 186 KLLVTADGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIK 245
K++VTA R + T + AI+ +D V DR G E
Sbjct: 184 KVVVTASYTQRRGKKIDLLTTVERAIDG--------LDFVEKVVVWDR---DGDALEEKG 232
Query: 246 DLYNWNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMY 305
L+ + ++E+++ S C PE + AEDPLF+LYTSG+TGKPKGV+HTT GY++
Sbjct: 233 GLF-------VDFNEMVKNASPECEPEVMDAEDPLFILYTSGTTGKPKGVLHTTGGYMVQ 285
Query: 306 AAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWS 365
T + VFD H D+YWCTAD+GWITGH+Y+VY LAN TSV+ EG P +P R+W
Sbjct: 286 TYYTSKIVFDLHEDDIYWCTADIGWITGHSYIVYGILANGVTSVITEGAPDYPDPGRWWR 345
Query: 366 IINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTR 425
+ KY+V FYTAPTAIR M + E+ + DLSSLR+LGSVGEPINP AWLWYY
Sbjct: 346 YVEKYRVNVFYTAPTAIRMFMRY--GEEWPMKY-DLSSLRILGSVGEPINPEAWLWYYKY 402
Query: 426 IGKERCSIVDTFWQTETGGHVITGLPGATPMKPGAAEK 463
IG+E+C IVDT+WQTETG H+IT +P + P KPG A K
Sbjct: 403 IGREKCVIVDTWWQTETGAHMITTIP-SYPAKPGKAGK 439
Score = 52.8 bits (121), Expect = 3e-05
Identities = 28/87 (32%), Positives = 49/87 (56%), Gaps = 3/87 (3%)
Query: 472 MDTF-RPKQGWDRTVMIVHLPNKSNRTRGFPFFGVEPKILNEDGVEIEGPGEGYLVFARP 530
+DT+ + + G I P K + G PFF +EP+I+++DG ++ G+LV P
Sbjct: 411 VDTWWQTETGAHMITTIPSYPAKPGKA-GKPFFTIEPEIVDKDGNKVPPNTVGFLVIKSP 469
Query: 531 WPGMMRTLLEDQDRFERVYFSKFPGYY 557
WP M+RT + +R+E+ Y++ G +
Sbjct: 470 WPSMLRTCWGEPERYEK-YWNTIKGVW 495
>UniRef50_A7ATQ7 Cluster: Acetyl-CoA synthetase, putative; n=1;
Babesia bovis|Rep: Acetyl-CoA synthetase, putative -
Babesia bovis
Length = 703
Score = 401 bits (987), Expect = e-110
Identities = 208/457 (45%), Positives = 286/457 (62%), Gaps = 29/457 (6%)
Query: 6 YKPTDHVIKKSYLPSIQKYKEMYERSLTESELFWTEVAQ-EFQWHVAPKPGGFMKYNFDI 64
Y P H +K ++ S+ +YKEM+ RSL + E FW ++A+ E +W + P F + +
Sbjct: 52 YPPIRHEGRKYHISSLDEYKEMHRRSLEDPEGFWGDMAKKELRW-IHP----FSRVSEGD 106
Query: 65 TKGRVFVKFMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQ 124
++ F+ ++N C N +DR + D IA EG+ P T +TYR+L VC+
Sbjct: 107 FTAADYMWFVG-GKINACENCVDRWAEERPND-IAIIAEGDDPTKVTTVTYRELRHNVCR 164
Query: 125 FANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAK 184
FAN L+ KG+RKGD V +YMP I E MLACARIGA+H+VVF G+S+ ++AER+ DA
Sbjct: 165 FANVLIDKGVRKGDVVTLYMPSIPELAYAMLACARIGAIHSVVFGGYSAASIAERIRDAD 224
Query: 185 AKLLVTADGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEI 244
+ +++T D ++RG + K D+A+ V C+V+ + + +
Sbjct: 225 SHIIITVDESYRGGKTIKMKSIVDEALLSCAG-----VTTCLVLRY-----------AGV 268
Query: 245 KDLYNWNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLM 304
K N E D W ++LE CP E + +ED LF+LYTSGSTG+PKGV HTT GYL+
Sbjct: 269 K--VNMKEGRDFWLDDLLEHVRPYCPIEVMDSEDSLFLLYTSGSTGRPKGVSHTTGGYLV 326
Query: 305 YAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYW 364
YA AT +Y+FD H D++ C AD+GWITGHTYVVY PL N T+ MF P +P RYW
Sbjct: 327 YAHATTKYIFDAHVGDIFGCVADLGWITGHTYVVYGPLLNGLTTFMFSSLPNYPDPGRYW 386
Query: 365 SIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYT 424
+I ++++TQFYTAPTAIR+LM H D D+SS+RVLGSVGEPINP AW WYY
Sbjct: 387 RMIEQHRITQFYTAPTAIRSLMRH---GDDYPRQYDISSVRVLGSVGEPINPEAWRWYYE 443
Query: 425 RIGKERCSIVDTFWQTETGGHVITGLPGATPMKPGAA 461
+G+ R ++VDT+WQTE GG V+ L G TPMKPG+A
Sbjct: 444 VVGRGRTNVVDTYWQTENGGIVVAPLAGVTPMKPGSA 480
Score = 200 bits (489), Expect = 8e-50
Identities = 103/205 (50%), Positives = 132/205 (64%), Gaps = 4/205 (1%)
Query: 501 PFFGVEPKILNE-DGVEI-EGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYC 558
PFFG++ +++ G EI + G LV RPWPG+ RTL R YFSK PG Y
Sbjct: 483 PFFGIDVALVDSATGKEILQNDVGGLLVVRRPWPGIFRTLYNSHKRGIVTYFSKVPGSYL 542
Query: 559 TGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGE 618
TGD RD+DGY+WI GR+DD LN+SGH + +A++E L V+EAA V PH +KG
Sbjct: 543 TGDAAYRDKDGYIWINGRVDDTLNISGHRIGSADIEHALVEVSYVAEAAAVAFPHPIKGN 602
Query: 619 ALYCFVVLKEGLQFDAD-LVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILR 677
++CFV LK+G D L + L L VR+ +G FA PD I ++P LPKTRSGKIMRRILR
Sbjct: 603 GIFCFVSLKDGFDIVHDVLERELKLAVRRIVGPFATPDIIISSPNLPKTRSGKIMRRILR 662
Query: 678 KIAVGD-HEVGDISTLADPGVVEEL 701
K+ G ++GD STLAD V+E L
Sbjct: 663 KLVSGQAKDLGDTSTLADQTVLEGL 687
>UniRef50_Q0I9W4 Cluster: Acetate--CoA ligase; n=19; cellular
organisms|Rep: Acetate--CoA ligase - Synechococcus sp.
(strain CC9311)
Length = 656
Score = 396 bits (976), Expect = e-109
Identities = 209/459 (45%), Positives = 285/459 (62%), Gaps = 28/459 (6%)
Query: 4 RMYKPTDHVIKKSYLPSIQKYKEMYERSLTESELFWTEVAQ-EFQWHVAPKPGGFMKYNF 62
R++ P + + + + + Y+ + E + ++ + FW + A+ E W +P + ++
Sbjct: 15 RVFDPPADLARDARISGMDSYRALAEAAKSDPDTFWGDAARRELHWF---EPFHTV-LDW 70
Query: 63 DITKGRVFVKFMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLV 122
D F ++ E N+ YN LDR++ K A WEG P D TY++L V
Sbjct: 71 D---NPPFARWFEGGTTNLSYNCLDRHLNGPKASKTALIWEGE-PGDVRTFTYQELHAEV 126
Query: 123 CQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSD 182
C+ AN L A GI KGD VA+YMPM+ EA I MLACARIGA H+VVF GFS++AL +RL D
Sbjct: 127 CRAANALKAIGIGKGDLVALYMPMVPEAAIAMLACARIGAPHSVVFGGFSAEALRDRLID 186
Query: 183 AKAKLLVTADGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKS 242
+ K ++TADG +R ++ K + A+ + V +VV D+
Sbjct: 187 GEVKAVITADGGFRKDKPVSLKPAVNAALANSAC---PTVKSVLVVKRTDQPV------- 236
Query: 243 EIKDLYNWNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGY 302
E+ D D WWHE++ +S+ C E +A+ED LFVLYTSGSTGKPKGVVHTTAGY
Sbjct: 237 EMVD------GRDQWWHELVAHQSDECTAEPMASEDRLFVLYTSGSTGKPKGVVHTTAGY 290
Query: 303 LMYAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDR 362
++ TF+++FD DV+WCTADVGWITGH+Y+VY PL+N AT+VM+EG P K
Sbjct: 291 NLWTHLTFQWIFDIRDDDVFWCTADVGWITGHSYIVYGPLSNGATTVMYEGAPRPSKPGA 350
Query: 363 YWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWY 422
+W +I K++V+ FYTAPTAIRA M D+SSLR+LG+VGEPINP AW+WY
Sbjct: 351 FWELIQKHRVSIFYTAPTAIRAFMRSGRAVPDQY---DMSSLRLLGTVGEPINPEAWMWY 407
Query: 423 YTRIGKERCSIVDTFWQTETGGHVITGLPGATPMKPGAA 461
+G ERC IVDT+WQTETGG +I+ LPGATP KPG+A
Sbjct: 408 RDVVGGERCPIVDTWWQTETGGVMISPLPGATPTKPGSA 446
Score = 186 bits (453), Expect = 2e-45
Identities = 100/225 (44%), Positives = 131/225 (58%), Gaps = 8/225 (3%)
Query: 485 VMIVHLPNKSNRTRG---FPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLED 541
VMI LP + G P G++ I++ +G GYL PWPGMMRT+ +
Sbjct: 430 VMISPLPGATPTKPGSATLPLPGIQADIIDAEGNSCGANEGGYLAVRAPWPGMMRTVHGN 489
Query: 542 QDRFERVYFSKF-PG----YYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGV 596
RF Y+ P Y GDG RRD DGY W+ GR+DD++NVSGH + T E+E
Sbjct: 490 PQRFRESYWEAIRPSDGSHLYFAGDGARRDADGYFWVMGRVDDVINVSGHRLGTMEIESA 549
Query: 597 LASDPRVSEAAVVPKPHEVKGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDT 656
L S P V+EAAVV +P ++KGE + FV L+ G + + LV L V ++IG A PD
Sbjct: 550 LVSHPAVAEAAVVGRPDDLKGEGIVAFVTLELGRESNDALVAELRTHVGKEIGPIARPDE 609
Query: 657 IQNAPGLPKTRSGKIMRRILRKIAVGDHEVGDISTLADPGVVEEL 701
I+ + LPKTRSGKIMRRILR +A G+ GD STL D V++ L
Sbjct: 610 IRCSDALPKTRSGKIMRRILRALAAGEEVTGDTSTLEDRSVLDRL 654
>UniRef50_A6G1J4 Cluster: Acetate--CoA ligase; n=1; Plesiocystis
pacifica SIR-1|Rep: Acetate--CoA ligase - Plesiocystis
pacifica SIR-1
Length = 658
Score = 392 bits (966), Expect = e-107
Identities = 203/452 (44%), Positives = 270/452 (59%), Gaps = 25/452 (5%)
Query: 16 SYLPSIQKYKEMYERSLTESELFW-TEVAQEFQWHVAPKPGGFMKYNFDITKGRVFVKFM 74
S + + Y+E + R + +W + Q W AP G + + G + +
Sbjct: 24 SQIQDMPAYREHWSRGEADPSGYWLAQTKQRVHWRKAPTQG-LEGDCWSVCDGPI--TWF 80
Query: 75 EEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGI 134
+ ELNV + LDR + GDK+A WEG+ P D +TY++L VC+ AN L G+
Sbjct: 81 ADGELNVTESCLDRQLAKR-GDKVAIVWEGDEPGDVRELTYKELHAEVCRCANALRELGL 139
Query: 135 RKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGA 194
+KG+R +YM M+ EA + MLACAR+GAVH+VVF GFS++AL +R+ D A +++T D
Sbjct: 140 KKGERAIIYMGMVPEAAVAMLACARLGAVHSVVFGGFSAEALRDRVRDCGASVVITQDVG 199
Query: 195 WRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEET 254
RG + K T D A+E + V+ +V S++ +K
Sbjct: 200 KRGSKNIPLKATTDQALEG-----EAGVEAVLVYQR------DASVEVAMK------AGR 242
Query: 255 DIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVF 314
D WWHE + S C AEDPLFVLYTSGSTG+PKG+VHT GYL + A T F
Sbjct: 243 DHWWHETVSPASAECEAVVCKAEDPLFVLYTSGSTGRPKGLVHTCGGYLTWTAYTHAVTF 302
Query: 315 DYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQ 374
D DVY C AD+GWITGH+Y+VY PL N ATS+MFE P +P VDRYW ++ ++K+T
Sbjct: 303 DLREDDVYACVADIGWITGHSYIVYGPLCNGATSLMFESVPTYPDVDRYWDMVARHKITI 362
Query: 375 FYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIV 434
FYTAPTAIR L A G + DLSSLRVLG+VGEPI+P AW WYY +G+ERC++V
Sbjct: 363 FYTAPTAIRVLAAQ---GPGPVRKHDLSSLRVLGTVGEPIDPVAWRWYYEVVGQERCAVV 419
Query: 435 DTFWQTETGGHVITGLPGATPMKPGAAEKKHP 466
DT+WQTETGGH IT + ATP KPG+A P
Sbjct: 420 DTWWQTETGGHCITPIAPATPEKPGSATLPMP 451
Score = 226 bits (553), Expect = 1e-57
Identities = 110/202 (54%), Positives = 137/202 (67%), Gaps = 1/202 (0%)
Query: 501 PFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYCTG 560
P G+ P ++NE G + GPGEG L A PWPGM RT+ D R+ YF+ FPG+Y TG
Sbjct: 449 PMPGIMPVLVNEHGRPMVGPGEGRLCIAHPWPGMARTVWGDHARYVMTYFTTFPGFYFTG 508
Query: 561 DGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEAL 620
DG RRD DGY WITGR+DD+LNVSGH M TAE E L + ++EAAVV PH VKG+ +
Sbjct: 509 DGCRRDADGYYWITGRVDDVLNVSGHRMGTAEFEAALIAIDELAEAAVVGYPHAVKGQGV 568
Query: 621 YCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKIA 680
+ +VV + G++ D L VR IGA A D +Q PGLPKTRSGK MRRILRKIA
Sbjct: 569 HAYVVAQPGVEADDALTAKAHEAVRGSIGAHARIDRLQYVPGLPKTRSGKCMRRILRKIA 628
Query: 681 VGD-HEVGDISTLADPGVVEEL 701
G+ ++GD+STLADP VV+ +
Sbjct: 629 EGEPDKLGDVSTLADPSVVDAI 650
>UniRef50_Q9PMD2 Cluster: Acetyl-coenzyme A synthetase; n=143;
cellular organisms|Rep: Acetyl-coenzyme A synthetase -
Campylobacter jejuni
Length = 657
Score = 392 bits (965), Expect = e-107
Identities = 210/473 (44%), Positives = 297/473 (62%), Gaps = 32/473 (6%)
Query: 2 SSRMYKPTDHVIKKSYLPSIQKYKEMYERSLTESELFWTEVA-QEFQWHVAPKPGGFMKY 60
+ ++KP+ + + + ++ +Y ++ + + + E FW A ++ +W F +
Sbjct: 6 NQELFKPSKEFSRNARIKNLCEYYDLCDEAKEDFEGFWKRQAFEKIEW--------FSPF 57
Query: 61 NFDITKGRV-FVKFMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLL 119
+ + + + F K+ E LNV Y LDR++K +K A +EG DY TYR+LL
Sbjct: 58 SRVLNEDKAPFYKWFEGGTLNVSYQCLDRHMKTR-RNKAALIFEGEM-GDYEVYTYRRLL 115
Query: 120 DLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAER 179
C+ AN L G++KGDRV +YMPMI E I MLACARIGA+H+VVF GFS +AL +R
Sbjct: 116 HETCKAANLLKKFGVKKGDRVVIYMPMIPETAIVMLACARIGAIHSVVFGGFSPEALRDR 175
Query: 180 LSDAKAKLLVTADGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGS 239
+ DA AKL+VTADGA+R + Y+ K A++KA + V+ ++V + P
Sbjct: 176 IIDAGAKLVVTADGAFRRGKPYMLK----PAVDKALSEGCESVEKVLIV--IRNNEPIEY 229
Query: 240 LKSEIKDLYNWNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTT 299
+K D ++E+++ ES C PE + +ED LF+LYTSGSTGKPKGV+H +
Sbjct: 230 IKGR-----------DYVYNELVKNESYKCEPEIMDSEDLLFLLYTSGSTGKPKGVMHAS 278
Query: 300 AGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPK 359
AGY+++A T +VFD D YWC+ADVGWITGHTYVVY PLA AT++M EGTP +P
Sbjct: 279 AGYILWAQMTMEWVFDIKDYDNYWCSADVGWITGHTYVVYGPLACGATTIMHEGTPTYPN 338
Query: 360 VDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAW 419
R+W +I +Y++++FYT+PTAIR L A E DLS+L VLG+VGEPINP+AW
Sbjct: 339 SGRWWRMIEEYQISKFYTSPTAIRMLHADAPNEPRKY---DLSTLEVLGTVGEPINPSAW 395
Query: 420 LWYYTRIGKERCSIVDTFWQTETGGHVITGLPGATPMKPGAAEKKHPVYYSSM 472
W+Y IG + IVDT+WQTETGGH+IT LPGATP+KPG A P ++ +
Sbjct: 396 KWFYDEIGGTKSPIVDTWWQTETGGHMITPLPGATPLKPGCATLPLPGIFAEV 448
Score = 163 bits (396), Expect = 1e-38
Identities = 95/234 (40%), Positives = 135/234 (57%), Gaps = 11/234 (4%)
Query: 486 MIVHLPNKSNRTRG---FPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQ 542
MI LP + G P G+ ++++E+G + + +G L +PWP M+R + +
Sbjct: 422 MITPLPGATPLKPGCATLPLPGIFAEVIDEEGNKKDEGEDGLLCITKPWPSMIRGIWGND 481
Query: 543 DRFERVYFSKFP----GYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLA 598
+R+ YFS+ Y +GDG D++GY+ ITGR DD++NV+GH + TAE+E +A
Sbjct: 482 ERYIESYFSQAKKDGKAVYFSGDGAFYDKNGYITITGRTDDVVNVAGHRIGTAEIESAIA 541
Query: 599 SDPRVSEAAVVPKPHEVKGEALYCFVVLKEGLQFD----ADLVKTLTLLVRQKIGAFAAP 654
P V+E+AVV +KGE+L+ FVVL D + +K L ++R +IG A
Sbjct: 542 KHPSVAESAVVSILDTIKGESLFAFVVLSPASSCDLGGAIETLKELNDILRVEIGPIAKI 601
Query: 655 DTIQNAPGLPKTRSGKIMRRILRKIAVGDHEVGDISTLADPGVVEELFNNRPAE 708
+ I PGLPKTRSGKIMRRILR IA G+ DISTL D VVE + AE
Sbjct: 602 EKILYTPGLPKTRSGKIMRRILRTIARGEEIKQDISTLEDSKVVETIVKLAKAE 655
>UniRef50_O25686 Cluster: Acetyl-coenzyme A synthetase; n=40;
Bacteria|Rep: Acetyl-coenzyme A synthetase -
Helicobacter pylori (Campylobacter pylori)
Length = 662
Score = 392 bits (964), Expect = e-107
Identities = 207/463 (44%), Positives = 299/463 (64%), Gaps = 32/463 (6%)
Query: 2 SSRMYKPTDHVIKKSYLPSIQKYKEMYERSLTESELFWTEVA-QEFQWHVAPKPGGFMKY 60
+ +++ P K++ + ++ +YK++ + + E FW ++A Q+ W KP F K
Sbjct: 10 AKKIFNPNRAFAKQARIKNMCEYKDLVHEANEDYEHFWGDLAKQKLTWF---KP--FDKV 64
Query: 61 -NFDITKGRVFVKFMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLL 119
N D F K+ E ++NV YN +DR++K+ +K+A +EG DY ITYRKL
Sbjct: 65 LNSD---NAPFFKWFENGKINVSYNCIDRHLKDK-KNKVAIIFEGEM-GDYNVITYRKLH 119
Query: 120 DLVCQFANGLLAK-GIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAE 178
V + AN L + ++KGDRV +YMPMI+E+V MLAC RIGA+H++VFAGFS +AL +
Sbjct: 120 SEVNKTANLLKNEFNVKKGDRVIIYMPMIVESVYMMLACTRIGAIHSIVFAGFSPEALRD 179
Query: 179 RLSDAKAKLLVTADGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGG 238
R++DA+AKL++TADG +R + Y+ K D A+E V+ ++V
Sbjct: 180 RINDAQAKLVITADGTFRKGKPYMLKPALDKALENNAC---PSVEKALIVIR-------- 228
Query: 239 SLKSEIKDLYNWNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHT 298
K++ ++ D ++E++ +S+ C PE + +EDPLF+LYTSGSTGKPKGV H+
Sbjct: 229 ----NAKEI-DYVRGRDFVYNEMVNYQSDKCEPEMMDSEDPLFLLYTSGSTGKPKGVQHS 283
Query: 299 TAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFP 358
+AGYL++A T +VFD D +WCTAD+GWITGHTYVVY PLA AT+++ EGT +P
Sbjct: 284 SAGYLLWAQMTMEWVFDIRDNDNFWCTADIGWITGHTYVVYGPLACGATTLILEGTMSYP 343
Query: 359 KVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAA 418
R+W +I +Y+V +FYT+PTAIR L A E +L SL+VLG+VGEPINP A
Sbjct: 344 DYGRWWRMIEEYRVDKFYTSPTAIRMLHAKGENEPSKY---NLESLKVLGTVGEPINPTA 400
Query: 419 WLWYYTRIGKERCSIVDTFWQTETGGHVITGLPGATPMKPGAA 461
W W+Y +IG +CSIVDT+WQTETGGH+I+ LPGATP++ A
Sbjct: 401 WKWFYEKIGNSKCSIVDTWWQTETGGHIISPLPGATPIRASCA 443
Score = 170 bits (414), Expect = 1e-40
Identities = 91/211 (43%), Positives = 129/211 (61%), Gaps = 8/211 (3%)
Query: 501 PFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFS--KFPG--Y 556
P G+ ++LNEDG + + +G+L +PWP M+R + D+ R+ YFS K G
Sbjct: 446 PLPGIHAEVLNEDGTKTKPGEQGFLCITKPWPSMIRNIWGDEKRYIDSYFSQIKLNGEYV 505
Query: 557 YCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVK 616
Y +GDG DE+GY+ I GR DD++NVSGH + TAEVE ++ V+E AVV P +K
Sbjct: 506 YLSGDGAIVDENGYITIIGRTDDIVNVSGHRIGTAEVESAISKHEMVAECAVVGIPDAIK 565
Query: 617 GEALYCFVVLKEG----LQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIM 672
GE L+ FVVL +G L +L+K + ++ +IG A D + PGLPKTRSGKIM
Sbjct: 566 GEGLFAFVVLCDGAKCNLGESLELLKEMNHILSIEIGKIAKLDNVMYVPGLPKTRSGKIM 625
Query: 673 RRILRKIAVGDHEVGDISTLADPGVVEELFN 703
RR+L+ IA + D+STL D VV+E+ +
Sbjct: 626 RRLLKSIAKKEPITQDLSTLEDVNVVKEIMS 656
>UniRef50_Q27549 Cluster: Acetyl-coenzyme A synthetase; n=7;
Apicomplexa|Rep: Acetyl-coenzyme A synthetase -
Cryptosporidium parvum
Length = 694
Score = 392 bits (964), Expect = e-107
Identities = 209/458 (45%), Positives = 284/458 (62%), Gaps = 29/458 (6%)
Query: 6 YKPTDHVIKKSY-LPSIQKYKEMYERSLTESELFWTEVAQ-EFQWHVAPKPGGFMKYNFD 63
YK K Y + I KYKE+YE+S+ + E FW+++A+ E +W F K
Sbjct: 43 YKSKPTPADKPYRVDGIDKYKELYEQSIRDPEGFWSQMARKELRWL-----RDFTKVRSS 97
Query: 64 ITKGRVFVKFMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVC 123
T + + + +LNVC N +DR + + A WEG+ P I+Y +L VC
Sbjct: 98 GTCLQDRLAWFLNGKLNVCDNCVDRWAEIQ-PNTTALIWEGDDPSSIRHISYIELFRNVC 156
Query: 124 QFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDA 183
+ AN L GI+KGD V +YMPMI E + MLACARIGAVH VVFAGF++ L ERL +A
Sbjct: 157 KMANVLKRFGIKKGDSVGIYMPMIPETIYTMLACARIGAVHMVVFAGFAAQNLLERLVNA 216
Query: 184 KAKLLVTADGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSE 243
+ K++VTAD RG+++ K D A+EK + C+V HL+ P +K
Sbjct: 217 RCKIVVTADQGSRGKKIINLKDVVDKALEKIP-----EIKTCIVFRHLNG--PIEFVKGR 269
Query: 244 IKDLYNWNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYL 303
+++ ET ++ E CP E + +EDPLF LYTSGSTG PKGV H+TAGYL
Sbjct: 270 -----DFDGET------LMRSEKPYCPLEDMDSEDPLFYLYTSGSTGTPKGVQHSTAGYL 318
Query: 304 MYAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRY 363
+YAA T +Y+F+ H D++ C D+GWITGH+Y+VYAPL N T+++FEG P +P RY
Sbjct: 319 LYAAVTQKYLFNIHPGDIFGCAGDIGWITGHSYLVYAPLCNGITTLIFEGVPTYPNAGRY 378
Query: 364 WSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYY 423
W ++ ++++T FY APTAIR L + D + D SSLRVLGSVGEPINP+AW WY+
Sbjct: 379 WEMVERHRITHFYAAPTAIRTLK---RLGDDFVKKHDRSSLRVLGSVGEPINPSAWRWYH 435
Query: 424 TRIGKERCSIVDTFWQTETGGHVITGLPGATPMKPGAA 461
+ +G+ERCSIVDT+WQTETGG VI +PG KPG+A
Sbjct: 436 SVVGEERCSIVDTYWQTETGGIVIAPIPGCFDTKPGSA 473
Score = 204 bits (498), Expect = 6e-51
Identities = 106/211 (50%), Positives = 135/211 (63%), Gaps = 10/211 (4%)
Query: 500 FPFFGVEPKILNED-GVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYC 558
FPFFG+EP IL+ D G EI+GPG G L WPGM R + E +Y FP YY
Sbjct: 475 FPFFGIEPAILDPDTGKEIDGPGSGVLCIKNSWPGMFRGIFGAHYLHE-IYTKPFPKYYF 533
Query: 559 TGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGE 618
TGDGV RD+DGYLWITGRIDD +NVSGH +S+ E+E L + ++EAA V H+VKG
Sbjct: 534 TGDGVLRDQDGYLWITGRIDDTINVSGHRLSSKEIEDALTNHFGIAEAAAVAIDHDVKGN 593
Query: 619 ALYCFVVLKEGLQFDADLVKT--------LTLLVRQKIGAFAAPDTIQNAPGLPKTRSGK 670
AL CFVVLK+ DL + L + VR +IG A PD I +PKTRSGK
Sbjct: 594 ALVCFVVLKDSGNRTFDLNNSSPHPFEYELRMCVRTQIGPVATPDHIIVVENIPKTRSGK 653
Query: 671 IMRRILRKIAVGDHEVGDISTLADPGVVEEL 701
++RR+LRKIA G ++ GDIST+A+P ++ +
Sbjct: 654 VVRRLLRKIATGCNDYGDISTVANPECIKSI 684
>UniRef50_Q8ZUB3 Cluster: Acetyl-coenzyme A synthetase; n=4;
Archaea|Rep: Acetyl-coenzyme A synthetase - Pyrobaculum
aerophilum
Length = 651
Score = 375 bits (922), Expect = e-102
Identities = 246/684 (35%), Positives = 358/684 (52%), Gaps = 58/684 (8%)
Query: 23 KYKEMYERSLTESELFWTEVAQEFQWHV--APKPGGFMKYNFDITKGRVFVKFMEEAELN 80
KY E+Y R L +S+ +W E ++ ++ A KP ++N F K+ N
Sbjct: 7 KY-EVYNRWLQDSDGYWQEFIEKTAGYIYWAKKPEKIFEWN----PPNPF-KWFVGGYTN 60
Query: 81 VCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRV 140
Y+ +D + FGDK A+ + RITY +L LVC+ + L A G++KGD +
Sbjct: 61 AGYSAVDYKLGR-FGDKTAYIYINPEASVERRITYGELYQLVCRISAALRAFGVKKGDTI 119
Query: 141 AVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGERM 200
VYMP +EAV +LA ARIGAV + VFAGFS A+A+R+ + K++ T D + R R
Sbjct: 120 LVYMPNSIEAVAVLLAAARIGAVSSTVFAGFSPKAVADRIELVEPKIIFTQDYSLRRGRR 179
Query: 201 YVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIWWHE 260
K D+A+ K T+ R +V L G K + D+W E
Sbjct: 180 IALKENIDEAL-KLSTW---RPQAVVVKRAL------GEEKEPPME-----RGRDMWLEE 224
Query: 261 VLE-GESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRR 319
LE G+ C PE+V + +PLFVL TSG+T KPK VVH GY ++ V+
Sbjct: 225 FLEMGKHGNCTPEFVESNEPLFVLPTSGTTAKPKPVVHVHGGYQVWIVHGALLVYGLSSD 284
Query: 320 DVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAP 379
DV + T+D+GWI G +Y+V+AP TS++F+G +PK D +W II KYK T +T+P
Sbjct: 285 DVIFNTSDIGWIVGQSYIVFAPTIMGTTSILFDGAIDYPKPDLFWEIIEKYKPTLIWTSP 344
Query: 380 TAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQ 439
TA R LM + + DLSS++ + + GE +NP W W Y ++ ++D +WQ
Sbjct: 345 TAARMLM---RLGVSHARRHDLSSVKRVVTAGEVLNPEVWRWLYEEAFQKNVPVIDHWWQ 401
Query: 440 TETGGHVITGLPGATPMKPGAAEKKHPVYYSSMDTFRPKQGWDRTVMIVHLPNKSNRTRG 499
T L G A K PV M+ K G + G
Sbjct: 402 --------TELGGPAIGYYYALVKDMPVGLEFMEI---KPG----------------SAG 434
Query: 500 FPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPG--YY 557
P GVE ++++E G + +G LV RP+PGM TL +D R+ Y+ ++ G Y
Sbjct: 435 VPLPGVEVEVVDERGNAVSAGQKGTLVLKRPFPGMTPTLWKDHKRYMAEYWERYEGKLVY 494
Query: 558 CTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKG 617
TGD D++GY+W GR D+++ ++GH + T EVE L + P V+EAAVV P ++G
Sbjct: 495 YTGDAAYIDDEGYVWFGGRADEVIKIAGHRIGTIEVESALLTHPAVAEAAVVGVPDPIRG 554
Query: 618 EALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILR 677
EA+ FVVLK + +L K L VR+ G A ++ LPKTRSGKIMRR+L+
Sbjct: 555 EAIAAFVVLKPSWRPTEELRKELIEHVRKTFGPIAVFAGLEFVNMLPKTRSGKIMRRVLK 614
Query: 678 KIAVGDHEVGDISTLADPGVVEEL 701
++ G+ +GDIST+ D VEE+
Sbjct: 615 RLWTGE-PIGDISTIEDEASVEEI 637
>UniRef50_Q93LL2 Cluster: Acetyl-coenzyme A synthetase; n=165;
cellular organisms|Rep: Acetyl-coenzyme A synthetase -
Nostoc linckia
Length = 337
Score = 366 bits (901), Expect = e-100
Identities = 179/362 (49%), Positives = 239/362 (66%), Gaps = 28/362 (7%)
Query: 65 TKGRVFVKFMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQ 124
T G+V +K+ E+ LNV + LDR++ GD++A WEG+ P+ +++TYR+L VCQ
Sbjct: 1 TSGKVSIKWFEDGVLNVTESCLDRHLATR-GDQVAIIWEGDDPNADSKVTYRELHARVCQ 59
Query: 125 FANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAK 184
AN + G++KGDRV +Y+PMI EA + MLACARIGAVH++VF GFS D+L+ R+ D+
Sbjct: 60 LANAMRGMGVQKGDRVCIYLPMIEEAAVAMLACARIGAVHSIVFGGFSPDSLSSRIQDSD 119
Query: 185 AKLLVTADGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNH-LDRVTPGGSLKSE 243
LL+TAD RG R K D+A++ C + H + GG++ +
Sbjct: 120 CVLLITADEGRRGGRKVPLKVNADEALKT-----------CPSIRHVIVAKNTGGNVAMQ 168
Query: 244 IKDLYNWNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYL 303
E D WW + + + PE + AEDPLF+LYTSGSTGKPKGV+HTT GYL
Sbjct: 169 --------EGRDHWWADACDNQPKTSTPEPMGAEDPLFILYTSGSTGKPKGVLHTTGGYL 220
Query: 304 MYAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRY 363
++A+ T + VFDY ++YWCTADVGW+TGHTY+VY PLAN AT++MFEG P +P V R+
Sbjct: 221 VWASFTHQNVFDYRDGEIYWCTADVGWVTGHTYIVYGPLANGATTLMFEGVPNYPTVSRF 280
Query: 364 WSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLS--SLRVLGSVGEPINPAAWLW 421
W +I+K++V FYTAPTAIRALM DG + S SLR+LGSVGEPINP AWLW
Sbjct: 281 WEVIDKHQVNIFYTAPTAIRALM-----RDGEAPVKKTSRKSLRILGSVGEPINPEAWLW 335
Query: 422 YY 423
YY
Sbjct: 336 YY 337
>UniRef50_Q9NUB1 Cluster: Acetyl-coenzyme A synthetase 2-like,
mitochondrial precursor; n=35; Deuterostomia|Rep:
Acetyl-coenzyme A synthetase 2-like, mitochondrial
precursor - Homo sapiens (Human)
Length = 689
Score = 355 bits (874), Expect = 2e-96
Identities = 188/428 (43%), Positives = 259/428 (60%), Gaps = 28/428 (6%)
Query: 24 YKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRVFVKFMEEAELNVCY 83
Y + ++ E FW +A++ P ++ D + G++ + +LNV
Sbjct: 58 YPALSAQAAREPAAFWGPLARDTLVWDTPY---HTVWDCDFSTGKI--GWFLGGQLNVSV 112
Query: 84 NLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAVY 143
N LD++V+ + +A WE + P RITYR+LL+ C+ AN L G+ +GDRVA+Y
Sbjct: 113 NCLDQHVRKS-PESVALIWERDEPGTEVRITYRELLETTCRLANTLKRHGVHRGDRVAIY 171
Query: 144 MPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGERMYVY 203
MP+ AV MLACARIGAVHTV+FAGFS+++LA R++DAK K+++T + RG R+
Sbjct: 172 MPVSPLAVAAMLACARIGAVHTVIFAGFSAESLAGRINDAKCKVVITFNQGLRGGRVVEL 231
Query: 204 KRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIWWHEVLE 263
K+ D+A+ KH C V H+ V K + DL D+ + +
Sbjct: 232 KKIVDEAV-------KH----CPTVQHV-LVAHRTDNKVHMGDL-------DVPLEQEMA 272
Query: 264 GESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYW 323
E +C PE + +ED LF+LYTSGSTG PKG+VHT AGYL+YAA T + VFD+ D++
Sbjct: 273 KEDPVCAPESMGSEDMLFMLYTSGSTGMPKGIVHTQAGYLLYAALTHKLVFDHQPGDIFG 332
Query: 324 CTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIR 383
C AD+GWITGH+YVVY PL N ATSV+FE TP +P RYW + + K+ QFY APTA+R
Sbjct: 333 CVADIGWITGHSYVVYGPLCNGATSVLFESTPVYPNAGRYWETVERLKINQFYGAPTAVR 392
Query: 384 ALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTETG 443
L+ + D + D SSLR LGSVGEPIN AW W + +G RC++VDT+WQTETG
Sbjct: 393 LLLKY---GDAWVKKYDRSSLRTLGSVGEPINCEAWEWLHRVVGDSRCTLVDTWWQTETG 449
Query: 444 GHVITGLP 451
G I P
Sbjct: 450 GICIAPRP 457
Score = 204 bits (498), Expect = 6e-51
Identities = 95/205 (46%), Positives = 132/205 (64%), Gaps = 2/205 (0%)
Query: 501 PFFGVEPKILNEDGVEIEGPG-EGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYCT 559
PFFG+ P +++E G +EG G L ++ WPGM RT+ D RF YF +PGYY T
Sbjct: 472 PFFGIVPVLMDEKGSVVEGSNVSGALCISQAWPGMARTIYGDHQRFVDAYFKAYPGYYFT 531
Query: 560 GDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEA 619
GDG R E GY ITGR+DD++N+SGH + TAE+E +A P V E+AV+ PH++KGEA
Sbjct: 532 GDGAYRTEGGYYQITGRMDDVINISGHRLGTAEIEDAIADHPAVPESAVIGYPHDIKGEA 591
Query: 620 LYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKI 679
+ F+V+K+ +V+ L +V KI +A PD I LPKTRSGK+MRR+LRKI
Sbjct: 592 AFAFIVVKDSAGDSDVVVQELKSMVATKIAKYAVPDEILVVKRLPKTRSGKVMRRLLRKI 651
Query: 680 AVGD-HEVGDISTLADPGVVEELFN 703
+ E+GD +TL DP ++ E+ +
Sbjct: 652 ITSEAQELGDTTTLEDPSIIAEILS 676
>UniRef50_Q5FTV0 Cluster: Acetyl-coenzyme A synthetase; n=1;
Gluconobacter oxydans|Rep: Acetyl-coenzyme A synthetase
- Gluconobacter oxydans (Gluconobacter suboxydans)
Length = 635
Score = 351 bits (862), Expect = 5e-95
Identities = 181/404 (44%), Positives = 250/404 (61%), Gaps = 21/404 (5%)
Query: 79 LNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGD 138
LN N LDR+++ GD+ A W+ D TYR L + VC+ AN L +G++ GD
Sbjct: 61 LNASVNCLDRHLETR-GDQNALVWQAEETDRVVTFTYRTLHERVCRMANVLREQGVQTGD 119
Query: 139 RVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGE 198
RVA+++P + E +I MLACARIGA+H V+F GFS +A+A+RLSD+ A L++TA+ RG
Sbjct: 120 RVAIHLPSVPEGLIAMLACARIGAIHVVLFGGFSPEAIADRLSDSGAVLVITANMGRRGP 179
Query: 199 RMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIWW 258
+ +K T D A++ + V H+ V S +D + D+W
Sbjct: 180 KRIPFKTTLDAALDLRPE--------ALAVRHVLVV-------SVTQDDVDLTAGRDLWL 224
Query: 259 HEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHR 318
+L+ S C + + A PLF+LYTSGSTGKPKG+VH T GYL++A+ T VFD+
Sbjct: 225 TPLLDAASADCAAQDMPASAPLFLLYTSGSTGKPKGIVHGTGGYLVWASYTHELVFDHQE 284
Query: 319 RDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTA 378
D++WCTAD+GWITGHTY VY PL N T ++FEG P +P R+WS+I +KVT FYT+
Sbjct: 285 GDIFWCTADIGWITGHTYGVYGPLLNGGTILLFEGMPSYPGPGRWWSVIQDHKVTTFYTS 344
Query: 379 PTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFW 438
PTAIRALM D + DLSSLRVLG+VGEPI+ AW W+ +G RC+ VDT+W
Sbjct: 345 PTAIRALMRE---GDEVVQRHDLSSLRVLGTVGEPISQEAWSWFNDHVGGGRCAFVDTWW 401
Query: 439 QTETGGHVITGLPGATPMKPGAAEKKHPVYYSSM--DTFRPKQG 480
QTE+GG +I+ +PGA KP +A P + + + PK+G
Sbjct: 402 QTESGGIMISPVPGAVREKPASATLPLPGVHPVLLDERGAPKEG 445
Score = 199 bits (486), Expect = 2e-49
Identities = 96/202 (47%), Positives = 129/202 (63%), Gaps = 3/202 (1%)
Query: 501 PFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYCTG 560
P GV P +L+E G EG EG L WPG T+ D FER Y +PGYY TG
Sbjct: 427 PLPGVHPVLLDERGAPKEGATEGVLCLRGSWPGRALTIWNDAALFERTYLQSYPGYYFTG 486
Query: 561 DGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEAL 620
DG RRDEDGY WITGR+DD++NVSGH + +AE+E LA++ ++E+A + PH++KG+ +
Sbjct: 487 DGARRDEDGYYWITGRVDDVINVSGHRIGSAEIEDALATELAIAESAAIGVPHDLKGQGI 546
Query: 621 YCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKIA 680
++V ++ DL + K+G +AAP+ I P LPKTRSGK +RR+LRKIA
Sbjct: 547 VVYLVPRDNA--PEDLHIRAAKAITSKVGRYAAPERIHVVPDLPKTRSGKSVRRLLRKIA 604
Query: 681 VGDHE-VGDISTLADPGVVEEL 701
G+ E GD+STLADP +V L
Sbjct: 605 CGETEGFGDLSTLADPEIVATL 626
>UniRef50_A2E702 Cluster: AMP-binding enzyme family protein; n=2;
Trichomonas vaginalis G3|Rep: AMP-binding enzyme family
protein - Trichomonas vaginalis G3
Length = 649
Score = 351 bits (862), Expect = 5e-95
Identities = 219/661 (33%), Positives = 343/661 (51%), Gaps = 63/661 (9%)
Query: 22 QKYKEMYERSLTESELFWTEVAQEF-QWHVAPKPGGFMKYNFDITKGRVFVKFMEEAELN 80
+ YK+M + ++ FW+E A++ +W K + + + E ++N
Sbjct: 9 ETYKKMEKEAIENPTKFWSETAKDILKWESTDFKNIIGKIGDEKSC------WFEGGKIN 62
Query: 81 VCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRV 140
CYN +DR+ DK+A +EGN DD ++TY +LL VC+ AN L +KG+ KG V
Sbjct: 63 TCYNAVDRHAM-AHPDKVALLYEGNDIDDSRQMTYGELLQNVCKMANVLKSKGVTKGSHV 121
Query: 141 AVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGERM 200
A+Y P+ +E ++ MLACARIGA+HTV+F FS DAL+ R+ ++ A ++++ + R +
Sbjct: 122 AIYFPVSIEGIVSMLACARIGAIHTVIFGAFSGDALSYRIHNSDATVVISQESYKRAAKA 181
Query: 201 YVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIWWHE 260
K T +A++ ++++ L P L E++ + E
Sbjct: 182 IPMKTTLLNALKSCPNIKN------VIISGLTE-KPTEKLPYEVES-----------YQE 223
Query: 261 VLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRD 320
++ S+ C E + DPLF+LYTSGSTG+PKG++H GY + TF+YVFD + +
Sbjct: 224 LMAAASDKCDCEIMDGSDPLFILYTSGSTGEPKGIIHRVGGYTVATTLTFKYVFDTNEKS 283
Query: 321 VYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPT 380
++ CT+D+GWITGH+YV Y PL N +T+++F G P +P R W +I K K+T FYT+P+
Sbjct: 284 IFGCTSDIGWITGHSYVCYGPLLNGSTTLIFGGLPLWPDATRSWQLIQKLKLTHFYTSPS 343
Query: 381 AIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQT 440
A RA+ A D ++ D+SSLRV+GSVGE ++ ++ T +G+++C W
Sbjct: 344 AARAIAAKIKSVD-QVSQFDISSLRVIGSVGETLDEDTCIYMRTVLGRDKC------WLV 396
Query: 441 ETGGHVITGLPGATPMKPGAAEKKHPVYYSSMDTFRPKQGWDRTVMIVHLPNKS--NRTR 498
+T G AT + PG E P RP G T +++ PN + TR
Sbjct: 397 DTYWQTELGSIIATSV-PGI-ENLPPGIVG-----RPLFG---TEIVLAEPNGQIISTTR 446
Query: 499 GFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYC 558
P+I++ G L A PWPG+ + F+ Y + ++
Sbjct: 447 N-----PHPEIVHN----------GILCIATPWPGLANAAFKSTRSFKDRYIMQGTEFFL 491
Query: 559 TGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGE 618
GD + D G + ITGRIDD L V+GH + AEVE + V + AV+ P + +
Sbjct: 492 AGDTAQIDTKGNIRITGRIDDQLCVNGHRVGPAEVEEAILKVDGVEDVAVIGVPSKKTTQ 551
Query: 619 ALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRK 678
A+ FVV + Q ++V + + V Q GA P + LPKT S KI+R LR+
Sbjct: 552 AIIAFVVSADNSQ---EMVTKVAVKVTQNFGAIGRPQKVIFVKMLPKTNSAKIIRSYLRE 608
Query: 679 I 679
+
Sbjct: 609 L 609
>UniRef50_Q01574 Cluster: Acetyl-coenzyme A synthetase 1; n=40;
Fungi|Rep: Acetyl-coenzyme A synthetase 1 -
Saccharomyces cerevisiae (Baker's yeast)
Length = 713
Score = 347 bits (852), Expect = 8e-94
Identities = 193/450 (42%), Positives = 268/450 (59%), Gaps = 29/450 (6%)
Query: 17 YLPSIQKYKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRVFVK---F 73
+L +Q Y+ +++ S+ + F+ A +F P F+ D GR + +
Sbjct: 69 HLDGLQDYQRLHKESIEDPAKFFGSKATQFLNWSKPFDKVFIP---DPKTGRPSFQNNAW 125
Query: 74 MEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLL-AK 132
+LN CYN +DR+ +K A +EG+ P ITY++LL+ VCQ A L +
Sbjct: 126 FLNGQLNACYNCVDRHALKT-PNKKAIIFEGDEPGQGYSITYKELLEEVCQVAQVLTYSM 184
Query: 133 GIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTAD 192
G+RKGD VAVYMPM+ EA+I +LA +RIGA+H+VVFAGFSS++L +R++D +K+++T D
Sbjct: 185 GVRKGDTVAVYMPMVPEAIITLLAISRIGAIHSVVFAGFSSNSLRDRINDGDSKVVITTD 244
Query: 193 GAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNE 252
+ RG ++ KR DDA+ + +H + + R T S+ ++
Sbjct: 245 ESNRGGKVIETKRIVDDALRETPGV-RHVL--------VYRKTNNPSVA--------FHA 287
Query: 253 ETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRY 312
D+ W + P V +EDPLF+LYTSGSTG PKGV H+TAGYL+ A T RY
Sbjct: 288 PRDLDWATEKKKYKTYYPCTPVDSEDPLFLLYTSGSTGAPKGVQHSTAGYLLGALLTMRY 347
Query: 313 VFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKV 372
FD H+ DV++ D+GWITGHTYVVY PL +++FEGTP +P RYW II+++KV
Sbjct: 348 TFDTHQEDVFFTAGDIGWITGHTYVVYGPLLYGCATLVFEGTPAYPNYSRYWDIIDEHKV 407
Query: 373 TQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCS 432
TQFY APTA+R L D + L SLR LGSVGEPI W WY +IGK
Sbjct: 408 TQFYVAPTALRLLK---RAGDSYIENHSLKSLRCLGSVGEPIAAEVWEWYSEKIGKNEIP 464
Query: 433 IVDTFWQTETGGHVITGLP-GATPMKPGAA 461
IVDT+WQTE+G H++T L G TPMKPG+A
Sbjct: 465 IVDTYWQTESGSHLVTPLAGGVTPMKPGSA 494
Score = 195 bits (475), Expect = 4e-48
Identities = 99/215 (46%), Positives = 137/215 (63%), Gaps = 10/215 (4%)
Query: 500 FPFFGVEPKILNED-GVEIE-GPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYY 557
FPFFG++ +L+ + G E+ EG L WP RT+ ++ DR+ Y + +PGYY
Sbjct: 496 FPFFGIDAVVLDPNTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTYLNPYPGYY 555
Query: 558 CTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKG 617
TGDG +D+DGY+WI GR+DD++NVSGH +STAE+E + DP V+E AVV ++ G
Sbjct: 556 FTGDGAAKDKDGYIWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFNDDLTG 615
Query: 618 EALYCFVVLKEGLQFDA-------DLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGK 670
+A+ FVVLK + D+ K L VR+ IG FAAP I LPKTRSGK
Sbjct: 616 QAVAAFVVLKNKSSWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLPKTRSGK 675
Query: 671 IMRRILRKIAVGD-HEVGDISTLADPGVVEELFNN 704
IMRRILRKI G+ ++GD+STL++PG+V L ++
Sbjct: 676 IMRRILRKILAGESDQLGDVSTLSNPGIVRHLIDS 710
>UniRef50_O93730 Cluster: Acetyl-coenzyme A synthetase; n=11;
Archaea|Rep: Acetyl-coenzyme A synthetase - Pyrobaculum
aerophilum
Length = 670
Score = 344 bits (845), Expect = 6e-93
Identities = 192/457 (42%), Positives = 273/457 (59%), Gaps = 39/457 (8%)
Query: 14 KKSYLPSIQKYKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRVFVKF 73
+ Y P I Y + + +++ E FW VA+E +W KP + D + F K+
Sbjct: 24 RSKYTP-IDAYFKFHRQTVENLESFWESVAKELEWF---KPWDKV---LDASNPP-FYKW 75
Query: 74 MEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNS------PDDYTRITYRKLLDLVCQFAN 127
LN+ Y +DR+VK +K+A WEG P D ++TY L V + A
Sbjct: 76 FVGGRLNLSYLAVDRHVKTWRKNKLAIEWEGEPVDENGYPTDRRKLTYYDLYREVNRVAY 135
Query: 128 GLLAK-GIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAK 186
L G++KGD++ +Y+PM+ E I MLA RIGA+ +VVF+GFS+DALAER++D++++
Sbjct: 136 MLKQNFGVKKGDKITLYLPMVPELPITMLAAWRIGAITSVVFSGFSADALAERINDSQSR 195
Query: 187 LLVTADGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKD 246
+++TADG WR R+ K D A+EKA V+ +V+ L +KD
Sbjct: 196 IVITADGFWRRGRVVRLKEVVDAALEKATG-----VESVIVLPRLG-----------LKD 239
Query: 247 LYNWNEETDIWWHEVLEG--ESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLM 304
+ E D WW+++++G + PE V +E P F+LYTSG+TGKPKG+VH T G+ +
Sbjct: 240 V-PMTEGRDYWWNKLMQGIPPNAYIEPEPVESEHPSFILYTSGTTGKPKGIVHDTGGWAV 298
Query: 305 YAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYW 364
+ AT ++VFD D++WCTAD+GW+TGH+YVV PL AT V++EG P +P+ DR+W
Sbjct: 299 HVYATMKWVFDIRDDDIFWCTADIGWVTGHSYVVLGPLLMGATEVIYEGAPDYPQPDRWW 358
Query: 365 SIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYT 424
SII +Y VT FYT+PTAIR M Y E DLS+LR++ SVGEPINP AW W Y
Sbjct: 359 SIIERYGVTIFYTSPTAIRMFM-RYGEEWPR--KHDLSTLRIIHSVGEPINPEAWRWAYR 415
Query: 425 RIGKERCSIVDTFWQTETGGHVITGLPG--ATPMKPG 459
+G E+ + T+W TETGG VI+ PG PMKPG
Sbjct: 416 VLGNEKVAFGSTWWMTETGGIVISHAPGLYLVPMKPG 452
Score = 178 bits (434), Expect = 4e-43
Identities = 90/204 (44%), Positives = 127/204 (62%), Gaps = 1/204 (0%)
Query: 497 TRGFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGY 556
T G P G E +++E+G +GYLV +PWPGM+ + D +R+ + Y+S+FPG
Sbjct: 453 TNGPPLPGFEVDVVDENGNPAPPGVKGYLVIKKPWPGMLHGIWGDPERYIKTYWSRFPGM 512
Query: 557 YCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVK 616
+ GD +D+DGY+W+ GR D+++ V+GH + T E+E L S P V+E+AVV P +K
Sbjct: 513 FYAGDYAIKDKDGYIWVLGRADEVIKVAGHRLGTYELESALISHPAVAESAVVGVPDAIK 572
Query: 617 GEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRIL 676
GE FVVLK+G+ +L K L VR+ IG A P I LPKTRSGKIMRR+L
Sbjct: 573 GEVPIAFVVLKQGVAPSDELRKELREHVRRTIGPIAEPAQIFFVTKLPKTRSGKIMRRLL 632
Query: 677 RKIAVGDHEVGDISTLADPGVVEE 700
+ +A G +GD++TL D VEE
Sbjct: 633 KAVATG-APLGDVTTLEDETSVEE 655
>UniRef50_P27095 Cluster: Acetyl-coenzyme A synthetase; n=12;
cellular organisms|Rep: Acetyl-coenzyme A synthetase -
Methanothrix soehngenii
Length = 672
Score = 341 bits (838), Expect = 4e-92
Identities = 193/476 (40%), Positives = 271/476 (56%), Gaps = 39/476 (8%)
Query: 3 SRMYKPTDHVIKKSYLPSIQKYK----EMYERSLTESEL----FWTEVAQEF-QWHVAPK 53
+R++ P +++KS + K K E R+ S+ FW E+A+ + WH K
Sbjct: 21 TRIFNPPKELVEKSIVMQWMKKKGFKTEKEMRAWCSSDEHYLEFWDEMAKTYVDWH---K 77
Query: 54 PGGFMKYNFDITKGRVFVKFMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDD-YTR 112
P + K D + + E+N+ YN +DR+ K DK+A+ W D +
Sbjct: 78 P--YTKVMDD--SEMPYFHWFTGGEINITYNAVDRHAKGAKKDKVAYIWIPEPTDQPVQK 133
Query: 113 ITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFS 172
ITY L V +FANGL + G++KGDRV++YMPMI + I MLACA++G H VVF+GFS
Sbjct: 134 ITYGDLYKEVNKFANGLKSLGLKKGDRVSIYMPMIPQLPIAMLACAKLGVSHIVVFSGFS 193
Query: 173 SDALAERLSDAKAKLLVTADGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLD 232
S L +R + ++ ++T DG +R + K D+A A + V+ +V
Sbjct: 194 SKGLMDRAAHCGSRAIITVDGFYRRGKPVPLKPNADEAAGGAPS-----VEKIIVYK--- 245
Query: 233 RVTPGGSLKSEIKDLYNWNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKP 292
R S+K E D+WWH++++G+S C P WV E L++LYTSG+TGKP
Sbjct: 246 RAGVDVSMK----------EGRDVWWHDLVKGQSEECEPVWVDPEHRLYILYTSGTTGKP 295
Query: 293 KGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFE 352
KG+ H T G + A T +VFD DV+WCTAD+GW+TGH+Y+VYAPL TS+M+E
Sbjct: 296 KGIEHATGGNAVGPAQTLHWVFDLKDDDVWWCTADIGWVTGHSYIVYAPLILGMTSLMYE 355
Query: 353 GTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGE 412
G +P R+W I +KVT YTAPTA+R M E + DLSSLR+LGSVGE
Sbjct: 356 GAADYPDFGRWWKNIQDHKVTVLYTAPTAVRMFMKQ-GAEWPD--KYDLSSLRLLGSVGE 412
Query: 413 PINPAAWLWYYTRIGKERCSIVDTFWQTETGGHVITGLPGATPMKPGAAEKKHPVY 468
PINP AW+WY IG+ I+DT+WQTETG + + LP TP+KPG+ P Y
Sbjct: 413 PINPEAWMWYREHIGRGELQIMDTWWQTETGTFLNSPLP-ITPLKPGSCTFPLPGY 467
Score = 174 bits (423), Expect = 8e-42
Identities = 90/206 (43%), Positives = 131/206 (63%), Gaps = 7/206 (3%)
Query: 500 FPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKF------ 553
FP G + IL+E+G E+ G +V +P+P M+R D++RF + Y+ +
Sbjct: 462 FPLPGYDISILDEEGNEVPLGSGGNIVALKPYPSMLRAFWGDKERFMKEYWQFYWDVPGR 521
Query: 554 PGYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPH 613
G Y GD +RD+DGY +I GRIDD+L+V+GH ++ AEVE L + P+++EAAVV KP
Sbjct: 522 RGVYLAGDKAQRDKDGYFFIQGRIDDVLSVAGHRIANAEVESALVAHPKIAEAAVVGKPD 581
Query: 614 EVKGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMR 673
EVKGE++ FV+L+ G + +L K VR+ +G AAP + LPKTRSGKIMR
Sbjct: 582 EVKGESIVAFVILRVGNEPSPELAKDAIAFVRKTLGPVAAPTEVHFVNDLPKTRSGKIMR 641
Query: 674 RILRKIAVGDHEVGDISTLADPGVVE 699
R+++ A+G + VGDISTL +P V+
Sbjct: 642 RVVKARALG-NPVGDISTLMNPEAVD 666
>UniRef50_A5UUT7 Cluster: Acetate--CoA ligase; n=2; Roseiflexus|Rep:
Acetate--CoA ligase - Roseiflexus sp. RS-1
Length = 639
Score = 337 bits (828), Expect = 7e-91
Identities = 178/446 (39%), Positives = 254/446 (56%), Gaps = 34/446 (7%)
Query: 18 LPSIQKYKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRV-FVKFMEE 76
+ ++ Y+ +Y RS+ + + FW E AQ W F ++ + + F K+
Sbjct: 29 IANLTDYEAVYRRSIEDPQGFWAEAAQALHW--------FEPFHTVLDDSKAPFYKWFVG 80
Query: 77 AELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRK 136
+ N+ YN LDR+V+ +K+A WE + T TY +L V +FAN L + G+RK
Sbjct: 81 GKTNMAYNALDRHVQTWRKNKVALIWESEDGEVRT-YTYWQLYRDVNKFANVLKSLGVRK 139
Query: 137 GDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWR 196
GDRVA+Y E I MLACARIGAVHTVV+ G S++AL R+ DA AK+LV ADG+
Sbjct: 140 GDRVAIYTGRCPEQAIAMLACARIGAVHTVVYGGLSTEALRSRIDDAHAKVLVVADGSLL 199
Query: 197 GERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDI 256
++ K D A+E A + ++ C+V+ D+ D
Sbjct: 200 NGKIVKLKEIADQAVEHAPS-----IETCVVIRRTGHPV----------DI---RSGRDY 241
Query: 257 WWHEV--LEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVF 314
WWHE+ L S C E + AEDP F++YTSGSTGKPKGVVHT GY++ T +YV
Sbjct: 242 WWHELMALPIASARCESEVLDAEDPFFIIYTSGSTGKPKGVVHTLGGYMVDVYTTLKYVL 301
Query: 315 DYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQ 374
D+ D +CT+D GWI GH+ V+Y PL + T++M+EG P +P DR+W +I ++ VT
Sbjct: 302 DFKEEDTLFCTSDAGWIVGHSIVLYGPLMHGITTLMYEGAPAYPYPDRWWHLIERHGVTL 361
Query: 375 FYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIV 434
+TAPT +R LM + D DLS+LR+L GEP+NP AW W+Y IG+ RC ++
Sbjct: 362 MFTAPTGVRGLMRY---GDAWPKRRDLSTLRLLACAGEPLNPEAWRWFYEVIGQRRCPVI 418
Query: 435 DTFWQTETGGHVITGLPGATPMKPGA 460
D +WQTET +++ PMKPG+
Sbjct: 419 DNWWQTETSRPMLSNF-ACLPMKPGS 443
Score = 194 bits (472), Expect = 9e-48
Identities = 93/194 (47%), Positives = 126/194 (64%), Gaps = 1/194 (0%)
Query: 499 GFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYC 558
GFP GV +++E G + EG LV RPWP M+RT+ D R+ Y+S++PG Y
Sbjct: 445 GFPAPGVAIDVVDEQGQSVPPGVEGSLVITRPWPAMLRTIYGDDQRYIEQYWSRYPGMYL 504
Query: 559 TGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGE 618
TGD +RD DGY+WI GR DD++ VSG+ + TAEVE L S P V+EAAV+ PH V+G
Sbjct: 505 TGDAAKRDADGYIWIIGRTDDVIKVSGYRLGTAEVESALVSHPAVAEAAVIGLPHPVRGN 564
Query: 619 ALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRK 678
A++ FV+L+ G +L L V + +G A P+TI P LPKTRSGKIMRR+LR
Sbjct: 565 AIHAFVLLRAGHSPSEELANELKAHVGKVMGPIAKPETISFPPTLPKTRSGKIMRRVLRA 624
Query: 679 IAVGDHEVGDISTL 692
A+G+ +GD+ST+
Sbjct: 625 QALGE-PLGDLSTM 637
>UniRef50_P55912 Cluster: Propionate--CoA ligase; n=57;
Bacteria|Rep: Propionate--CoA ligase - Salmonella
typhimurium
Length = 628
Score = 336 bits (827), Expect = 9e-91
Identities = 229/686 (33%), Positives = 351/686 (51%), Gaps = 74/686 (10%)
Query: 24 YKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRVFVKFMEEAELNVCY 83
+ E Y+RS+ E E FW E A+ W +P D ++ F ++ N+C+
Sbjct: 3 FSEFYQRSINEPEAFWAEQARRIDWR---QP---FTQTLDHSRPP-FARWFCGGTTNLCH 55
Query: 84 NLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAVY 143
N +DR ++ + +A + D+ T+ +L D V A LL+ G+++GDRV VY
Sbjct: 56 NAVDR-WRDKQPEALALIAVSSETDEERTFTFSQLHDEVNIVAAMLLSLGVQRGDRVLVY 114
Query: 144 MPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGERMYVY 203
MPMI EA I +LACARIGA+H+VVF GF+S ++A R+ DA+ L+V+AD RG ++ Y
Sbjct: 115 MPMIAEAQITLLACARIGAIHSVVFGGFASHSVAARIDDARPALIVSADAGARGGKILPY 174
Query: 204 KRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIWWHEVLE 263
K+ DDAI +A+ KH V +DR G K W + D+ + + +
Sbjct: 175 KKLLDDAIAQAQHQPKH-------VLLVDR----GLAKMA------WVDGRDLDFATLRQ 217
Query: 264 GESNICPP-EWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVY 322
P W+ + + +LYTSG+TGKPKGV GY + A + +F V+
Sbjct: 218 QHLGASVPVAWLESNETSCILYTSGTTGKPKGVQRDVGGYAVALATSMDTIFGGKAGGVF 277
Query: 323 WCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAI 382
+C +D+GW+ GH+Y+VYAPL ++++EG P +P +W I+ KY+V + ++APTAI
Sbjct: 278 FCASDIGWVVGHSYIVYAPLLAGMATIVYEGLPTYPDCGVWWKIVEKYQVNRMFSAPTAI 337
Query: 383 RALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTET 442
R L + N DLSSL L GEP++ W +G ++D +WQTE+
Sbjct: 338 RVLKKFPTAQIRN---HDLSSLEALYLAGEPLDEPTASWVTETLG---VPVIDNYWQTES 391
Query: 443 GGHVITGLPGATPMKPGAAEKKHPVYYSSMDTFRPKQGWDRTVMIVHLPNKSNRTRGFPF 502
G + M A P S P G++ ++ N G
Sbjct: 392 GWPI---------MALARALDDRPSRLGSPGV--PMYGYNVQLL--------NEVTG--- 429
Query: 503 FGVEPKILNEDG-VEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKF-PGYYCTG 560
EP +NE G + IEGP P PG ++T+ D RF + Y+S F Y T
Sbjct: 430 ---EPCGINEKGMLVIEGP--------LP-PGCIQTIWGDDARFVKTYWSLFNRQVYATF 477
Query: 561 DGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEAL 620
D RD +GY +I GR DD++N++GH + T E+E ++S P V+E AVV +KG+
Sbjct: 478 DWGIRDAEGYYFILGRTDDVINIAGHRLGTREIEESISSYPNVAEVAVVGIKDALKGQVA 537
Query: 621 YCFVVLKEG-----LQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRI 675
FV+ K+ + D + LV +IG F P + LPKTRSGK++RR
Sbjct: 538 VAFVIPKQSDTLADREAARDEENAIMALVDNQIGHFGRPAHVWFVSQLPKTRSGKMLRRT 597
Query: 676 LRKIAVGDHEVGDISTLADPGVVEEL 701
++ I G + GD++T+ DP ++++
Sbjct: 598 IQAICEG-RDPGDLTTIDDPASLQQI 622
>UniRef50_Q9HQU8 Cluster: Acetyl-CoA synthetase; n=11; root|Rep:
Acetyl-CoA synthetase - Halobacterium salinarium
(Halobacterium halobium)
Length = 667
Score = 333 bits (819), Expect = 8e-90
Identities = 182/399 (45%), Positives = 247/399 (61%), Gaps = 19/399 (4%)
Query: 70 FVKFMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRI-TYRKLLDLVCQFANG 128
F ++ LN N LDR++ GD+ A W G D+ R TY +L V +FA G
Sbjct: 73 FYEWFPGGGLNASANCLDRHLDER-GDEAAIEWVGEPADEANRTYTYAQLHREVNEFAAG 131
Query: 129 LLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLL 188
L G+ + D V +YMPM+ E I MLACAR+GA H+VVFAGFS+DAL+ R++ A ++ L
Sbjct: 132 LREMGVGEDDIVTLYMPMVPELPIAMLACARLGAPHSVVFAGFSADALSTRMNAADSEYL 191
Query: 189 VTADGAWR-GERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDL 247
VT DG +R G+ + Y +T D H V +VV DR+ G +
Sbjct: 192 VTCDGYYRRGDPLDHYAKTLDGL-----DGVSHAVSDVVVV---DRLGANGDGFDHDRPA 243
Query: 248 YNWNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAA 307
+ + + + H+ +++ P E A D LF++YTSG+TG+PKGV H+T GYL +AA
Sbjct: 244 AHHDYDAVVAAHD----GASVSPVERDAT-DMLFLMYTSGTTGQPKGVTHSTGGYLSWAA 298
Query: 308 ATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSII 367
T + V D D Y+C+AD+GWITGH+Y+VY PLA T++++EG P P DR W ++
Sbjct: 299 WTSQAVLDIKPSDTYFCSADIGWITGHSYIVYGPLALGTTTMLYEGAPDHPDKDRLWELV 358
Query: 368 NKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIG 427
Y+ TQ YTAPTAIR+ M + VE + DLSSLR+LG+VGEPINP AW WYYT IG
Sbjct: 359 ESYEATQLYTAPTAIRSFM-KWGVEYPD--AHDLSSLRLLGTVGEPINPRAWTWYYTHIG 415
Query: 428 KERCSIVDTFWQTETGGHVITGLPGATPMKPGAAEKKHP 466
E C IVDT+WQTETGG ++TGLPG + MKPG+A + P
Sbjct: 416 DESCPIVDTWWQTETGGMMVTGLPGVSTMKPGSAGRPLP 454
Score = 171 bits (417), Expect = 4e-41
Identities = 93/229 (40%), Positives = 135/229 (58%), Gaps = 13/229 (5%)
Query: 485 VMIVHLPNKSNR---TRGFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLED 541
+M+ LP S + G P GV+ ++++ DG ++ G G+L +PWPGM++TL E+
Sbjct: 433 MMVTGLPGVSTMKPGSAGRPLPGVDARVIDTDGDDVAGGRAGHLTIQKPWPGMLQTLYEN 492
Query: 542 QDRFE----RVYFSKFPG-----YYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAE 592
+RF RVY G Y DG + D+DGY+ + GR+DD++NVSGH + T E
Sbjct: 493 DERFIDEYWRVYSDTDSGDSADWVYFPEDGAKVDDDGYITVLGRVDDVVNVSGHRLGTME 552
Query: 593 VEGVLASDPRVSEAAVVPKPHEVKGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFA 652
+E + P V+EAAVV H++KGEA+Y +V+ + L + + V IG A
Sbjct: 553 IESAIVDVPGVAEAAVVGGDHDLKGEAVYAYVLTTDDHDASDALRERIVASVEDAIGPIA 612
Query: 653 APDTIQNAPGLPKTRSGKIMRRILRKIAVGDHEVGDISTLADPGVVEEL 701
P+ + AP LPKTRSGKIMRR+L IA D ++GD STL +P VVE +
Sbjct: 613 RPEAVVFAPELPKTRSGKIMRRLLEDIA-NDADLGDTSTLRNPDVVETI 660
>UniRef50_Q869S4 Cluster: Similar to Bradyrhizobium japonicum.
Acetyl-coenzyme A synthetase; n=2; Dictyostelium
discoideum|Rep: Similar to Bradyrhizobium japonicum.
Acetyl-coenzyme A synthetase - Dictyostelium discoideum
(Slime mold)
Length = 655
Score = 329 bits (809), Expect = 1e-88
Identities = 236/687 (34%), Positives = 347/687 (50%), Gaps = 70/687 (10%)
Query: 1 MSSRMYKPTDHVIKKSY-LPSIQKYKEMYERSLTESELFWTEVAQEF-QWHVA-PKPGGF 57
+S + T ++ K Y L Y++ E +L E FW EVA ++ W+ K
Sbjct: 28 ISKLSFSSTSILLNKKYKLSEPFNYEQDCEYALKEPIQFWDEVASKYVHWNKRYEKVYSG 87
Query: 58 MKYNFDITKGRVFVKFMEEAELNVCYNLLDRNVKNGFG-DKIAFFWEGNSPDDYTRITYR 116
+YN + KG V LN CYN LD + K+ ++IA E S ++ ++TY
Sbjct: 88 DEYNPEWFKGGV---------LNACYNALDVHAKDPITKNRIAIIHETPSKNNTNKLTYG 138
Query: 117 KLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDAL 176
+L D VC FA GL G+ KGDRV +YMPMI +A+I MLACAR+GA H+VVF GF+S L
Sbjct: 139 ELWDEVCIFARGLHNLGVEKGDRVVIYMPMINQALIAMLACARLGATHSVVFGGFASPQL 198
Query: 177 AERLSDAKAKLLVTADGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTP 236
A+R+ K K++++A+ G ++ Y A+E + H+ + +V N LD
Sbjct: 199 AQRIEHFKPKVVISANFGVEGHKINCYTPLLSKALELS----SHKPNHTIVYNRLD---- 250
Query: 237 GGSLKSEIKDLYNWNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVV 296
+K + ++ E + W E+++ + V + PL++LYTSG+TG PKGVV
Sbjct: 251 ---VKLDAGEVLPPRVEGSLDWSELIKNIAPYRDYALVDSTHPLYILYTSGTTGMPKGVV 307
Query: 297 HTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPY 356
T GY + + R + D ++ +DVGW+ GHT VY PL TS++FEG P
Sbjct: 308 RDTGGYSVALNYSIRNCYGMKSGDTFFAGSDVGWVVGHTLSVYGPLMVGLTSIIFEGKPT 367
Query: 357 FPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMP-DLSSLRVLGSVGEPIN 415
P YW +I K++V ++APTAIRA+ H + DG L DLSSLR + GE ++
Sbjct: 368 VPDASTYWKLIEKHRVNALFSAPTAIRAI--HRDDADGKLASKCDLSSLRSIWLGGERLD 425
Query: 416 PAAWLWYYTRIGKERCSIVDTFWQTETGGHVITGLPGATPMKPGAAEKKHPVY-YSSMDT 474
+ + + R I+D +W TE+G +IT P+K A K P Y + +
Sbjct: 426 SST--FNFLRNITNNKPILDNYWNTESGSPLITNPSCQVPIKANATGKPMPGYQFHVLSP 483
Query: 475 FRPKQGWDRT-VMIVHLPNKSNRTRGFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPG 533
+ G D+ + + LP V P N + EG YL +PG
Sbjct: 484 TSERLGADKIGEVCIKLP-------------VAPGFTNTLYLNPEGYKNAYL---NEYPG 527
Query: 534 MMRTLLEDQDRFERVYFSKFPGYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEV 593
+RT D GYY DE+GY I R+DD++NVSGH +ST +
Sbjct: 528 YLRT--ADS------------GYY--------DENGYYHIISRVDDIINVSGHRLSTGSI 565
Query: 594 EGVLASDPRVSEAAVVPKPHEVKGEALYCFVVLKEGLQFDADLVKT-LTLLVRQKIGAFA 652
E +L P++ E AV+ E+KGE + VVLK + A+ V+ L VR+ IG A
Sbjct: 566 EEILVKHPKIVECAVIGVHDELKGEIPFGLVVLKPQYKDCAEEVENELIKEVRENIGPVA 625
Query: 653 APDTIQNAPGLPKTRSGKIMRRILRKI 679
+ + LPKT SGKI+R ILRK+
Sbjct: 626 TFKKVLSVNRLPKTGSGKILRNILRKM 652
>UniRef50_UPI00015B60D2 Cluster: PREDICTED: similar to
ENSANGP00000011599; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000011599 - Nasonia
vitripennis
Length = 684
Score = 324 bits (795), Expect = 7e-87
Identities = 231/697 (33%), Positives = 343/697 (49%), Gaps = 70/697 (10%)
Query: 9 TDHVIKKS-YLPSIQKYKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKG 67
+D+++ ++ Y +I Y+E + +S+ E FW E+ Q +W +P + N
Sbjct: 37 SDYILNQNRYRSTI--YEEAFRKSIENPEEFWAEIGQCIEWS---RPWDRVLDN----SN 87
Query: 68 RVFVKFMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFAN 127
F K+ E N CYN +DR+V G G K A + + R++Y +LLD + A
Sbjct: 88 EPFTKWYVGGETNACYNAVDRHVAAGLGSKTALIHDSPMTETVRRVSYAELLDRTSRLAG 147
Query: 128 GLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKL 187
L G+ +GDRV +YMP+I E ++ +LA AR+GAVH+VVF GF++ LA R+ A+ K+
Sbjct: 148 ALAELGVSRGDRVLIYMPLIPETIVAILATARLGAVHSVVFGGFAAKELATRIDHAEPKV 207
Query: 188 LVTADGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDL 247
+V A ++ Y +DA+ H C VV + L+S++
Sbjct: 208 IVAASCGLEPGKVVKYTDMLNDAMNLISVAAPH----C-VVYQRRHIWEAPLLESQLD-- 260
Query: 248 YNWNEETDIWWHEVLE-GESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYA 306
W ++LE E + C P V A PL++LYTSG+T KPKG+ G++
Sbjct: 261 ----------WDDLLEHAEPHPCVP--VEANQPLYILYTSGTTDKPKGIQRPIGGHIATL 308
Query: 307 AATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTP-YFPKVDRYWS 365
T ++ + V+W +D+GW+ G +Y+ Y PL ATSVM+EG P P +Y+
Sbjct: 309 CWTMNAIYGMDKNSVWWVASDLGWVVGLSYICYGPLLYGATSVMYEGKPDRTPDAGQYFR 368
Query: 366 IINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTR 425
II+++KV +T PTA R L + E SLR + GE + A W +
Sbjct: 369 IIDEHKVNALFTVPTAFRVL-RRADPETHLGRKYSTKSLRTIFVAGEHCDYEAKAW-AEK 426
Query: 426 IGKERCSIVDTFWQTETGGHVITGLPGATPMKPGAAEKKHPVYYSSMDTFRPKQGWDRTV 485
+ K I++ +WQTET GH IT AT + G P YS T P G+ V
Sbjct: 427 VFK--VPILNHWWQTET-GHAIT----ATCL--GLGHTTSPPKYS---TGMPFPGYYVEV 474
Query: 486 MIVHLPNKSNRTRGFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRF 545
+ R G EP L V + P PG M TL RF
Sbjct: 475 L---------REDGSK---AEPHELGRIAVRLPLP-----------PGTMSTLYHAPGRF 511
Query: 546 ERVYFSKFPGYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSE 605
+ +YFSK+PGYY T D DE GY+++T R DD++NV+GH +ST+ +E V+ P V +
Sbjct: 512 KEIYFSKYPGYYDTMDAGYIDEYGYVFVTARDDDVINVAGHRLSTSALEDVVLGHPEVVD 571
Query: 606 AAVVPKPHEVKGEALYCFVVLKEGLQFDADLVKT-LTLLVRQKIGAFAAPDTIQNAPGLP 664
AAVV P KGE C V+++ + + T L VR+ IG AA + LP
Sbjct: 572 AAVVGVPEHTKGEIPLCLYVMRDHSRKSEQEINTELIARVRELIGPIAAFKVAASVKALP 631
Query: 665 KTRSGKIMRRILRKIAVGDHEVGDISTLADPGVVEEL 701
+TRSGK R+ + +A H V ST+ DP V ++
Sbjct: 632 RTRSGKTCRKSIADLARSKH-VQIPSTIDDPTVYRDI 667
>UniRef50_Q9VC92 Cluster: CG6432-PA; n=7; cellular organisms|Rep:
CG6432-PA - Drosophila melanogaster (Fruit fly)
Length = 674
Score = 316 bits (776), Expect = 1e-84
Identities = 214/686 (31%), Positives = 334/686 (48%), Gaps = 70/686 (10%)
Query: 24 YKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRVFVKFMEEAELNVCY 83
Y + Y +S+ FW E W +P + N F K+ LN CY
Sbjct: 28 YLKAYRQSVQNPAAFWEEQGNLLDWD---RPWEKVLDN----SNPPFTKWYVGGYLNACY 80
Query: 84 NLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAVY 143
N +DR++ G G +A + R+TY++L D + A GL G+ KGDRV +Y
Sbjct: 81 NSIDRHILAGRGSNVALIHDSPLTGTLRRVTYQELYDQIVLLAGGLAKLGVVKGDRVVIY 140
Query: 144 MPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGERMYVY 203
MP+I E +I MLA R+GA+H+VVF GF++ L R+ + KL++ ++ ++ Y
Sbjct: 141 MPLIPETIIAMLAIVRLGAIHSVVFGGFAARELCSRIEHVEPKLVIASNVGVEPGKVVPY 200
Query: 204 KRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIWWHEVL- 262
D + A + + R ++ D V+P D + TD+ W ++L
Sbjct: 201 L----DILHSAISMSRWRPPQRNIIFRRDNVSP---------DTTKLDPLTDVLWSDILK 247
Query: 263 --EGESNI-CPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRR 319
EGE I C P + A DPL++LYTSG+T KPKGV+ T G+L+ T R ++ +
Sbjct: 248 MAEGERPIACVP--IEANDPLYILYTSGTTDKPKGVLRTIGGHLVALVYTLRTLYGINPG 305
Query: 320 DVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTP-YFPKVDRYWSIINKYKVTQFYTA 378
+W +D+GW+ GH+Y+ Y PL ATSVM+EG P P +Y+ II++Y+V ++
Sbjct: 306 HTWWAASDMGWVVGHSYICYGPLCLGATSVMYEGKPDRTPDPGQYFRIIDQYQVRSIFSV 365
Query: 379 PTAIRAL-MAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTF 437
PT+ R + A ++ G + SLR + GE + W + +++ +
Sbjct: 366 PTSFRVIRRADPDISYGR--QYSMKSLRAIFIAGEHCDYETKSWIEKTF---KVPVLNHW 420
Query: 438 WQTETGGHVITGLPGATPMKPGAAEKKHPVYYSSMDTFRPKQGWDRTVMIVHLPNKSNRT 497
WQTETG V AT + G + P YS T P G+D ++
Sbjct: 421 WQTETGSAVT-----ATCL--GFQQNLSPPTYS---TGLPLMGYDVKIL----------- 459
Query: 498 RGFPFFGVEPKILNEDGVEIEGPGEGYLVFARPW-PGMMRTLLEDQDRFERVYFSKFPGY 556
DG E + G + P PG M TL ++++ F +YF KFPGY
Sbjct: 460 -------------KADGSEAQTSELGRIALKLPLPPGNMATLYKNEELFRTLYFQKFPGY 506
Query: 557 YCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVK 616
Y T D +DE GY+++T R DD++NV+GH +ST+ +E + P V + AV P K
Sbjct: 507 YDTMDAGYKDERGYIFVTARDDDVINVAGHRLSTSSLEDAVLRHPDVVDVAVFGVPEATK 566
Query: 617 GEALYC-FVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRI 675
G+ C ++ ++ + DA L + L+R +G AA + + LP+TRSGK MR+
Sbjct: 567 GQVPLCLYIPVENCKKTDAKLSTEIIKLIRDVVGPIAAFRLVTSVNNLPRTRSGKTMRKA 626
Query: 676 LRKIAVGDHEVGDISTLADPGVVEEL 701
+ A + V +T+ D V E+
Sbjct: 627 MADFARNERVVLP-ATIDDASVFIEI 651
>UniRef50_Q8SRZ9 Cluster: ACETYLCOENZYME A SYNTHETASE; n=1;
Encephalitozoon cuniculi|Rep: ACETYLCOENZYME A
SYNTHETASE - Encephalitozoon cuniculi
Length = 632
Score = 316 bits (776), Expect = 1e-84
Identities = 182/443 (41%), Positives = 251/443 (56%), Gaps = 34/443 (7%)
Query: 23 KYKEMYERSLTESELFWTEVAQEF-QWHVAPKPGGFMKYNFDITKGRVFVKFMEEAELNV 81
+Y+ +Y+RS+ + E FW E A+ +W YN D R F E LN
Sbjct: 5 EYEGLYKRSIEDKEGFWGEQAKVLLKWDRMFD----RVYNNDFENSRWF----EGGMLNA 56
Query: 82 CYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVA 141
CYN +DR+ DK+A +EGN + T++ +LD V + L +G+ KGD VA
Sbjct: 57 CYNCVDRHAACS-PDKVAVIYEGNDGES-VYYTFKDVLDEVIRICTILKDEGLEKGDTVA 114
Query: 142 VYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGERMY 201
+YM M AV LACAR+G VH +F GFS+ ++A RL+D+ AKLL+ D R +
Sbjct: 115 MYMAMSPYAVFSALACARLGLVHNAIFGGFSASSVALRLNDSNAKLLIVQDVVARQDSTM 174
Query: 202 VYKRTCDDAIEKARTFFKHR-VDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIWWHE 260
+ +E R K + + + + LD + +I D + + W +
Sbjct: 175 NF-------LENTRVALKGKSIPVLVFDTFLD--------ERKILDSLDGIGGRILIWSK 219
Query: 261 VLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRD 320
VL+ E+ P V AED LF LYTSGSTGKPKG++HT GYL+YA T + FD D
Sbjct: 220 VLKRENEFIPCVSVNAEDRLFYLYTSGSTGKPKGIIHTAGGYLVYAMLTSKICFDLQEND 279
Query: 321 VYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPT 380
V+ CTAD+GWITGHTYV+Y PL N T+V+F GTP++P R + ++ KY++TQ YTAPT
Sbjct: 280 VFACTADIGWITGHTYVIYGPLLNGITTVVFGGTPFYPSYYRLFKMVEKYRITQLYTAPT 339
Query: 381 AIRALMAHYNVE--DGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFW 438
IR L H++ D N DLSSLR+LGSVGEPIN A LW+ C ++DT+W
Sbjct: 340 VIRMLRKHFSTTPLDHNY---DLSSLRILGSVGEPINKNAHLWFSENF--NGCPVIDTYW 394
Query: 439 QTETGGHVITGLPGATPMKPGAA 461
QTE+GG +I +P A +KP A
Sbjct: 395 QTESGGILIAPIPHAVDIKPECA 417
Score = 157 bits (380), Expect = 1e-36
Identities = 84/206 (40%), Positives = 121/206 (58%), Gaps = 7/206 (3%)
Query: 501 PFFGVE-----PKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPG 555
PF G E P ++ VE + G ++ WPG+ R +L + +RF + YF + G
Sbjct: 420 PFLGQEVVIADPSSRSDCVVEAKAYELGRVLLKGSWPGITRGILGNPERFRKGYFF-YKG 478
Query: 556 YYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEV 615
+Y TGD +D DG++WI GR DD++NVSGH +STAEVEG +DP ++EAA V + ++
Sbjct: 479 FYFTGDEGYKDSDGHVWIRGRADDVINVSGHRISTAEVEGAACTDPHIAEAAAVAESDDI 538
Query: 616 KGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRI 675
G+AL FVVLK+ + +L +R KIG F I G+PKT +GKIMRR+
Sbjct: 539 TGQALCIFVVLKDRKTSHEGVRASLRTTLRSKIGKFVNAKRIYFCEGIPKTATGKIMRRV 598
Query: 676 LRKIAVGDHEVGDISTLADPGVVEEL 701
L+ I GD GD+ST + ++E L
Sbjct: 599 LKSILAGD-PPGDVSTCTNADIIEGL 623
>UniRef50_Q871W2 Cluster: Related to acetyl coenzyme A synthetase;
n=9; Pezizomycotina|Rep: Related to acetyl coenzyme A
synthetase - Neurospora crassa
Length = 694
Score = 312 bits (766), Expect = 2e-83
Identities = 223/698 (31%), Positives = 351/698 (50%), Gaps = 60/698 (8%)
Query: 26 EMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNF-DITKGRVFV--KFMEEAELNVC 82
E SLT+ E FW A++ WH KP +K D+ G ++ + E++ C
Sbjct: 7 EAQHLSLTDPEGFWGHQAEQLHWH--RKPSAVLKRTTKDLKLGTSHSHWEWFPDGEISTC 64
Query: 83 YNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAV 142
YN LDR+V G GD+ A ++ + + R+TY++LL V FA L +G++KGD V V
Sbjct: 65 YNCLDRHVLAGHGDQPAILYDSSVTNTKQRLTYKQLLAEVETFAGVLREEGVKKGDVVLV 124
Query: 143 YMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGERMYV 202
YMPM+ +I +LA R+GA+H VVF GF+S ALA+R+ ++ ++TA G + V
Sbjct: 125 YMPMVPATLIGILAINRLGAIHAVVFGGFASTALAQRIEASRPVAILTASCGIEGNKGPV 184
Query: 203 YKRTCDDAIEKARTFFKHRVDMCMVVNHLDRV-TPGGSLKSEIKDLYNWNEETDIWWHEV 261
R IE+A + + ++ V P + E +W +
Sbjct: 185 SYRA---YIEEAISISSFKPPKTIIWQREQLVWRPIKKTEGE----RDWQKLVKSARFRN 237
Query: 262 LEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYH-RRD 320
++ E C P V + DP++++YTSG+TG+PKGVV + G+ + + Y+F H D
Sbjct: 238 IKVE---CVP--VRSADPIYIIYTSGTTGRPKGVVRDSGGHAVGLHMSISYLFGIHGPGD 292
Query: 321 VYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPY-FPKVDRYWSIINKYKVTQFYTAP 379
V C +D+GW+ H+Y +Y PL A +V++EG P P +W + +YK+ +TAP
Sbjct: 293 VMGCFSDIGWVVSHSYTLYGPLLTGAATVLYEGKPVGTPDASAFWRLAEEYKINTLFTAP 352
Query: 380 TAIRALMAH--YNVEDGNL-TMPDLSSLRVLGSVGEPINPAAWLWY---YTRIGKERCSI 433
TA+RA+ NV + L SL+ L GE PA Y R G +
Sbjct: 353 TALRAIRKEDPDNVFITEIGRRGGLKSLKALFLAGERSEPAIINMYQDLLRRYGAAGSQV 412
Query: 434 VDTFWQTETGGHVITGLPGATPMKPGAAEKKHPVYYSSMDTFRPKQGWDRTVMIVHLPNK 493
VD +W +E+G + + P A + + ++M P LP K
Sbjct: 413 VDNWWSSESGSPI-----SGVALVPHAGKNRK----TNMKDHPP------------LPIK 451
Query: 494 SNRTRGFPFFGVEPKILNEDGVEIEGPGEGYLVFARPW-PGMMRTLLEDQDRFERVYFSK 552
+ G G + ++++++G E+ G +V P P RTL D++RF + Y +
Sbjct: 452 PG-SAGKAMPGFDVRVVDDEGNEVPRGNMGNIVLGLPLAPTAFRTLWGDEERFYKSYMIR 510
Query: 553 FPGYYC-TGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPK 611
F G + TGD D+ GY+ I R DD++NV+ H +ST +E + S P V+EA VV
Sbjct: 511 FNGKWVDTGDAGYVDQTGYIHIMARTDDIINVAAHRLSTGTLEQAVTSHPLVTEACVVSV 570
Query: 612 PHEVKGEALYCFVVLKEG---LQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPG-LPKTR 667
P +KG+ + FV +G ++ D L + + LVR ++GA A+ + G +PKTR
Sbjct: 571 PDALKGQLPFAFVSTSDGGADVKSDEQLFQDIQKLVRAQVGAIASLGGMIRGKGMIPKTR 630
Query: 668 SGKIMRRILRKI---AVGDH---EVGDISTLADPGVVE 699
SGK +RR+LR++ AV D + ST+ DP VV+
Sbjct: 631 SGKTLRRVLRELLENAVHDEFEKPINIPSTVEDPSVVD 668
>UniRef50_Q1JYJ4 Cluster: AMP-dependent synthetase and ligase; n=1;
Desulfuromonas acetoxidans DSM 684|Rep: AMP-dependent
synthetase and ligase - Desulfuromonas acetoxidans DSM
684
Length = 621
Score = 296 bits (726), Expect = 2e-78
Identities = 208/671 (30%), Positives = 341/671 (50%), Gaps = 77/671 (11%)
Query: 20 SIQKYKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRVFVKFMEEAEL 79
S Q+Y+E +S S LF T + +WH +P + N + ++ +L
Sbjct: 14 SAQQYEEYQAQSA--STLFDTLAQKYIEWH---EPYRKVLDNM----APPYYRWYTGGKL 64
Query: 80 NVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDR 139
NV +N+L R+++ +K A W G + ++ T TY+ L V NGL+ G++KGDR
Sbjct: 65 NVYHNILGRHLETERRNKAALIWRGANFEERT-YTYQTLAHEVLAMINGLVHLGVKKGDR 123
Query: 140 VAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGER 199
V ++MP I E VI M+ACA IGA+H +S++ALA+RL+ +AK ++T DGA + R
Sbjct: 124 VLLFMPDIPETVIAMIACASIGAIHVAYHMAYSAEALAQRLNHCQAKFIITCDGAHQRTR 183
Query: 200 MYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIWWH 259
K ++A+E+ + ++ C+VVNH + + DIW+H
Sbjct: 184 SL--KGVVNEALER----LDYEINHCIVVNHTHKQVL-------------MRPQRDIWYH 224
Query: 260 EVLEGE--SNICPPEWVA-AEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDY 316
+++ S + V A++PLF++YTS + KP+ VH+ AGYL++A T +FD
Sbjct: 225 DLITDPEFSRGATVDLVRHADEPLFMIYTSTKSKKPRAAVHSLAGYLVWAQFTTELLFDL 284
Query: 317 HRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFY 376
D++W TAD+ W+ GHTY VY PLA AT ++EGT + ++ ++K+ VT Y
Sbjct: 285 DDMDIFWNTADLVWVNGHTYSVYGPLALGATLFLYEGTISYENTQFFFDYLDKFHVTVLY 344
Query: 377 TAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDT 436
T PT +R++M + + +SLR++G GE I+ + W + R +
Sbjct: 345 TTPTILRSVMRAKSTK--RYLNRSSNSLRLIGCGGEKISEDLYDWTQFELTNNRNLPITQ 402
Query: 437 FW-QTETGGHVITGLPGATPMKPGAAEKKHPVYYSSMDTFRPKQGWDRTVMIVHLPNKSN 495
W QTETGG +I G+PG +G++ M+ LP
Sbjct: 403 IWGQTETGGCLIAGVPGV-------------------------RGFEDDTMMAPLPGVEA 437
Query: 496 RTRGFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFP- 554
R + +L++ G PG LV A P P M++ L +D+ +++ ++ K+P
Sbjct: 438 R-----LVDAQGHVLDQPG----EPGR--LVLATPLPSMLQDLYKDEVGYQQTFWKKYPE 486
Query: 555 -GYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPH 613
Y+ TGDG D+ G L +TGR+DD+L+ S E+E + + RV E A + H
Sbjct: 487 RTYFSTGDGAIYDDKGNLNLTGRLDDILSTGAGRRSLDEIEETVLTMKRVRECAAIVIDH 546
Query: 614 EVKGEALYCFVVLKEGLQFDADLVKTLTLL---VRQKIGAFAAPDTIQNAPGLPKTRSGK 670
+G L + VLK+ + ++ KTL + + ++IG PD I+ LPKT +
Sbjct: 547 PSQGYILVTYCVLKD-FRDESYREKTLREVREHIIEEIGELNLPDKIRFTKYLPKTPDNR 605
Query: 671 IMRRILRKIAV 681
+ R +L++IA+
Sbjct: 606 VNRDLLKEIAL 616
>UniRef50_Q247U0 Cluster: AMP-binding enzyme family protein; n=1;
Tetrahymena thermophila SB210|Rep: AMP-binding enzyme
family protein - Tetrahymena thermophila SB210
Length = 691
Score = 287 bits (703), Expect = 9e-76
Identities = 218/696 (31%), Positives = 344/696 (49%), Gaps = 75/696 (10%)
Query: 20 SIQKYKEMYERSLTES--ELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRV-FVKFMEE 76
+I +Y ++Y S+ E E FW + A+ W F K + + K + F ++ +
Sbjct: 2 NIGQYNKLYNESVQEKSKEQFWQKAAENLHW--------FKKPSKILDKSQPPFYRWYSD 53
Query: 77 AELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTR---ITYRKLLDLVCQFANGLLAKG 133
E+N+CYN +DR+ G+K A WE S + TY++L + V + A L G
Sbjct: 54 GEINICYNAIDRHQAQ-HGNKTALIWESPSLKSSVQSETYTYKQLYENVAKLAWVLKQFG 112
Query: 134 IRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTAD- 192
++KGDRV +Y+P + EAV MLAC+RIGA+H VV+ G+ + LA R+ + + KL++TA
Sbjct: 113 VKKGDRVIIYLPNVPEAVFSMLACSRIGAIHVVVYGGYPAKELAGRIIECQPKLIITASA 172
Query: 193 GAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNE 252
G RG+++ YK D A+E + +H + + ++V +T LK + Y++
Sbjct: 173 GIERGDKIIYYKGIVDAALEMSG---QHNL-ISLIVQRDIHMTSNFVLKRD----YDYYT 224
Query: 253 ETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRY 312
I LE E C E + + DPL++L++SG PKG+VH AG +Y ++
Sbjct: 225 ALKI---AQLETE---C--EHMNSNDPLYILFSSGEN-HPKGIVHDHAGTAVYCDWQMKH 275
Query: 313 VFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEG-TPYFPKVDRYWSIINKYK 371
+ D D + DVGWI GH +++Y AT++++EG + P ++W II+KY
Sbjct: 276 ILDIGSNDTLFSATDVGWIVGHIFMIYGAFIKGATTILYEGRSTGTPDNIQFWRIIDKYN 335
Query: 372 VTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERC 431
V +T PT+IR + + N L+SL+ + + GE + + I K
Sbjct: 336 VKCLFTNPTSIREIRKE-DPNGMNTKKFKLTSLQSVHTTGEHTDQETSEYLKKHINKN-L 393
Query: 432 SIVDTFWQTETGGHVITGLPGATPMKPGAAEKKHPVYYSSMDTFRPKQGWDRTVMIVHLP 491
I + + Q E G GA +P S +F+ K G
Sbjct: 394 FINNIYIQQEIG---------------GAISANYP---QSFQSFQDKPG----------- 424
Query: 492 NKSNRTRGFPFFGVEPKILNEDGVEIEGPGE-GYLVFARPWPG-MMRTLLEDQDRFERVY 549
+ T P F V IL+ +IE + G + P P M +L + + F + Y
Sbjct: 425 ---SVTMPCPSFEVH--ILDNQNKKIEEANKLGKVCLKTPLPPPFMLSLFNNDEIFMKKY 479
Query: 550 FSKFPGYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVV 609
PGYY TGD DED YLW+ GRIDD++ G +S + VE VL S P + AAVV
Sbjct: 480 LGDSPGYYTTGDAGFFDEDSYLWVVGRIDDIIKTGGKKLSMSSVEQVLQSAPEIVNAAVV 539
Query: 610 PKPHEVKGEALYCFVVLKEG--LQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTR 667
K E GE FVV+++G ++ + L LV +IG++A + P LP+TR
Sbjct: 540 SKYDETLGEVPVGFVVIEKGKLIKNKQQFLSQLVDLVDVEIGSYANFKQVIIVPRLPQTR 599
Query: 668 SGKIMRRILRKIAVGDHEVGDISTLADPGVVEELFN 703
+G+I+R +L+KI + + ++ D VVEE+ N
Sbjct: 600 NGEILRSLLKKI-INEENYKIPPSIEDESVVEEIKN 634
>UniRef50_A7HB74 Cluster: AMP-dependent synthetase and ligase; n=8;
cellular organisms|Rep: AMP-dependent synthetase and
ligase - Anaeromyxobacter sp. Fw109-5
Length = 650
Score = 281 bits (688), Expect = 6e-74
Identities = 155/393 (39%), Positives = 219/393 (55%), Gaps = 26/393 (6%)
Query: 78 ELNVCYNLLDRNVKNGFGD---KIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGI 134
+LN N +DR+V FGD K A W G +++T TY +L V +FAN L G+
Sbjct: 91 KLNATVNCIDRHV---FGDRRLKAALIWVGEDGEEHT-YTYNRLYREVNRFANALKKLGV 146
Query: 135 RKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGA 194
RKGDRV +YMP+ E +I MLACARIGA+H+VVFAG + AL R+ D AK++V +D
Sbjct: 147 RKGDRVLLYMPLTPEGIISMLACARIGAIHSVVFAGMGTQALRSRIEDCAAKVVVCSDYT 206
Query: 195 WRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEET 254
+R + K T D+A+ +H V+ H PG + + + E
Sbjct: 207 YRRGKKVPLKPTVDEAVRDLYGV-EH------VIVHRRGSRPGDAP-------FTFESER 252
Query: 255 DIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVF 314
+ ++++ +G + CPPE + +EDPLF+LYTSG+TGKPKGVVHTT GYL+ R +
Sbjct: 253 EHDFYDIQDGHAIHCPPEPMDSEDPLFILYTSGTTGKPKGVVHTTGGYLVGTTYLARAYY 312
Query: 315 DYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQ 374
D+YW T+D+GWI GH+++VY PL+ AT EG P +P D W + +Y V
Sbjct: 313 QITDSDIYWSTSDIGWIVGHSFIVYGPLSAGATIFTREGVPDYPSPDVTWELCERYGVNV 372
Query: 375 FYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTR-IGKERCSI 433
+TAPTA+R M+H DL LR++ GEP+NP A W +G+ + +
Sbjct: 373 MFTAPTAVRMWMSHGGDAPSRY---DLQKLRLIACAGEPLNPEAHRWAQANLVGQSKGMV 429
Query: 434 VDTFWQTETGGHVITGLPGATPMKPGAAEKKHP 466
VD +WQTE V+ LP +PG K P
Sbjct: 430 VDNWWQTEIAAPVLGTLP-TFDARPGKVGKPVP 461
Score = 163 bits (396), Expect = 1e-38
Identities = 84/196 (42%), Positives = 120/196 (61%), Gaps = 2/196 (1%)
Query: 499 GFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYC 558
G P G + +++ G + G LV +P P M+RT+ D R+E+ Y+S+ PG Y
Sbjct: 457 GKPVPGADVAVVDAAGKPVSDGEGGLLVIRKPLPYMLRTIWNDHARYEK-YWSQIPGVYT 515
Query: 559 TGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGE 618
GD RD DGY + GR DD++NV+GH + TA+VE L P V+E+AV+ P VKGE
Sbjct: 516 AGDIAVRDRDGYFAVLGRADDVMNVAGHRIGTADVESALLRHPAVAESAVIGLPDPVKGE 575
Query: 619 ALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRK 678
+ FVVL++G+ LV +L VRQ +G A P ++ LPKTRSGKIMRR+L+
Sbjct: 576 KIKAFVVLRKGVPQGPGLVASLKDHVRQDLGPIATPADVELRASLPKTRSGKIMRRLLKA 635
Query: 679 IAVGDHEVGDISTLAD 694
+ +G + GD+ST+AD
Sbjct: 636 VEMG-QDPGDVSTMAD 650
>UniRef50_Q127M4 Cluster: AMP-dependent synthetase and ligase; n=4;
cellular organisms|Rep: AMP-dependent synthetase and
ligase - Polaromonas sp. (strain JS666 / ATCC BAA-500)
Length = 688
Score = 277 bits (679), Expect = 8e-73
Identities = 159/413 (38%), Positives = 232/413 (56%), Gaps = 24/413 (5%)
Query: 65 TKGRVFVKFMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTR-ITYRKLLDLVC 123
T F ++ ++N CYN +DR++ +K A + D+ + +TY++L V
Sbjct: 85 TSNPPFWRWFVGGKINACYNCVDRHLGQ-HKNKTAIHFVPEPEDEAPQHLTYQELFVRVN 143
Query: 124 QFANGLLAK--GIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLS 181
+FA LL G++ GDRV ++MPM+ E I MLACAR+G +H+ VF+GFS A A+R++
Sbjct: 144 EFA-ALLRDFCGLKAGDRVTLHMPMVAELPITMLACARLGVIHSQVFSGFSGKACADRVA 202
Query: 182 DAKAKLLVTADGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLK 241
D+++++L+T D R + +K D A+ +A + + +VD ++ PG +
Sbjct: 203 DSESRVLITMDAYHRAGNLLDHKEKADIAVMEAASHGQ-QVDKVLIWQRY----PGKN-S 256
Query: 242 SEIKDLYNWNEETDIWWHEVLEG-ESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTA 300
S K + E D ++VL+ P + AE PLF++YTSG+TG+PKG H
Sbjct: 257 SPTKLV----EGRDFVINDVLKQFRGKRVEPVQMPAEAPLFLMYTSGTTGRPKGCQHGIG 312
Query: 301 GYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKV 360
GYL Y T +++ D H DVYWC AD+GWITGH+Y+VY PLA AA+SV++EG P +P
Sbjct: 313 GYLAYVTWTSKFIQDIHPEDVYWCMADIGWITGHSYIVYGPLALAASSVVYEGVPTYPDA 372
Query: 361 DRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWL 420
R W I V F+T+PTAIRAL E + + +VGEPI P W
Sbjct: 373 GRPWRIAENLDVNIFHTSPTAIRALRRDGPDEPAKYN----HHFKHMTTVGEPIEPEVWK 428
Query: 421 WYYTRIGKERCSIVDTFWQTETGGHVITGLPGATPMKPG----AAEKKHPVYY 469
WY+ +GK IVDT+WQTE GG + + +P MKPG A HPV Y
Sbjct: 429 WYHRMVGKGEAVIVDTWWQTENGGFLCSTVPAIHKMKPGSTGPAIPGIHPVIY 481
Score = 148 bits (358), Expect = 6e-34
Identities = 86/231 (37%), Positives = 129/231 (55%), Gaps = 17/231 (7%)
Query: 484 TVMIVHLPNKSNRTRGFPFFGVEPKILNEDGVE-IEGPGE-GYLVFARPWPGMMRTLLED 541
TV +H + P G+ P I +++G E + G G+ G + PWPG +T+ +D
Sbjct: 457 TVPAIHKMKPGSTGPAIP--GIHPVIYDDEGKELVSGSGKAGNICIRNPWPGGFQTIWKD 514
Query: 542 QDRFERVYFSKFPGY----------YCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTA 591
+R+ R Y++++ Y GDG + DGY I GRIDD++NV+GH + T
Sbjct: 515 PERYVRQYYARYCADPKSKDWRDWPYMAGDGAVQAADGYYRILGRIDDVINVAGHRLGTK 574
Query: 592 EVEGVLASDPRVSEAAVVPKPHEVKGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAF 651
E+E P V EAAVVP +KG+ +V LK GL ++ ++ V +IGA
Sbjct: 575 EIESAALLVPEVVEAAVVPVADPIKGKVPDLYVALKPGLAPSEEIANRVSASVVSEIGAI 634
Query: 652 AAPDTIQNAPGLPKTRSGKIMRRILRKIAVGDH-EVGDISTLADPGVVEEL 701
A P + P +PKTRSGKIMRR+L A+ +H + GD+STLA+P VV+++
Sbjct: 635 ARPRRVIVVPDMPKTRSGKIMRRVL--AAISNHLDPGDVSTLANPEVVDKI 683
>UniRef50_A1CSK5 Cluster: Acyl-CoA synthetase, putative; n=7;
Pezizomycotina|Rep: Acyl-CoA synthetase, putative -
Aspergillus clavatus
Length = 716
Score = 276 bits (677), Expect = 1e-72
Identities = 207/716 (28%), Positives = 335/716 (46%), Gaps = 72/716 (10%)
Query: 27 MYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRVFVKF--MEEAELNVCYN 84
++ SL + E FW+ + WH P ++ + G + + E++ YN
Sbjct: 8 VHAHSLQDPESFWSHHTAQLHWHKPPSRA-LVRQPKTLPSGVTHEHWAWFPDGEISTTYN 66
Query: 85 LLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAVYM 144
+DR+V G GD A W+ TYR+LLD V A L +G+RKGD V +YM
Sbjct: 67 CVDRHVAAGRGDHAAIIWDSAVTGVQETYTYRRLLDEVEVLAGVLREEGVRKGDVVIIYM 126
Query: 145 PMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGERMYV-Y 203
PMI A+I LA R+GA+H+ VF GF++ +LA+R+ A+ ++++TA G + V Y
Sbjct: 127 PMIPAALIAALAITRLGAIHSAVFGGFAAKSLAQRIEAARPRVVMTASCGIEGSKGPVAY 186
Query: 204 KRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIWWHEVLE 263
+ + AI A + FK + L P ++ NW +
Sbjct: 187 RPLVEGAI--AASSFKPFKTLIWQREQLRWDNP-----DKVSGQRNWQRLVK---SARMR 236
Query: 264 GESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRR-DVY 322
G P V + D L+++YTSG+TG PKGV G+ + + +Y+FD H DV
Sbjct: 237 GVR--AGPVPVKSTDGLYIIYTSGTTGLPKGVYREAGGHAVGLHLSIKYLFDIHGPGDVM 294
Query: 323 WCTADVGWITGHTYVVYAPLANAATSVMFEGTPY-FPKVDRYWSIINKYKVTQFYTAPTA 381
+C +D+GW+ GH+Y++Y PL AT+V+FEG P P +W I+ +++ +TAPTA
Sbjct: 295 FCASDIGWVVGHSYILYGPLLVGATTVLFEGKPVGTPDAGTFWRIVEQHRAKVLFTAPTA 354
Query: 382 IRALMAHYNVEDGNLT------MPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVD 435
+RA+ + L + +L + G EP A+ T+ +VD
Sbjct: 355 MRAIRKDDPDDQFFLQVARRGGLKHFKALFLAGERSEPSIVQAYQKLLTQHAAPGAMVVD 414
Query: 436 TFWQTETGGHVITGLPGATPMKPGAAEKKHPVYYSSMDTFRPKQGWDRTVMIVHLPNKSN 495
+W +E+G I+GL + + + +++ R + G
Sbjct: 415 NWWSSESGS-PISGLALRSVAGLVQQQPQQDGQHTNPAPLRVRPG--------------- 458
Query: 496 RTRGFPFFGVEPKILNEDGVEIEGPGEGYLVFARP-WPGMMRTLLEDQDRFERVYFSKFP 554
+ G P G + +I+++DG E+ G +V A P P +L D +RF + Y +F
Sbjct: 459 -SAGLPMPGFDVRIVDDDGKEVPRGTMGNIVMAMPLGPTAFTSLFNDDERFYKGYLKRFH 517
Query: 555 GYYC-TGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAE--------------------- 592
G + TGD D++GY+ I R DD++NV+ H ST
Sbjct: 518 GQWMDTGDAGMVDDEGYVHIMSRSDDIINVAAHRFSTGNTPTPPLSLAHGLRMLFTIAIT 577
Query: 593 --VEGVLASDPRVSEAAVVPKPHEVKGEALYCFVVLKEG-----LQFDADLVKTLTLLVR 645
+E + S P + EA+VV P +KG + F+ ++G + A+L + VR
Sbjct: 578 GAIEQAILSHPDIGEASVVGIPDPLKGHLPFAFIQPRDGTGALPARPSAELFAAVNAAVR 637
Query: 646 QKIGAFAA-PDTIQNAPGLPKTRSGKIMRRILRKIAVGDHEVGDISTLADPGVVEE 700
++IGA A+ IQ +PKTRSGK +RR+LR++ T++ P VE+
Sbjct: 638 EQIGAIASLGGMIQGRGMIPKTRSGKTLRRVLRELVEQGVRGEFAGTVSIPPTVED 693
>UniRef50_Q4J9J7 Cluster: Acetyl-coenzyme A synthetase; n=4;
Sulfolobaceae|Rep: Acetyl-coenzyme A synthetase -
Sulfolobus acidocaldarius
Length = 654
Score = 271 bits (664), Expect = 5e-71
Identities = 159/443 (35%), Positives = 250/443 (56%), Gaps = 30/443 (6%)
Query: 20 SIQKYKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRVFVKFMEEAEL 79
+++ YK +Y++S+ E FW +A+ P K F +G + K+ E +L
Sbjct: 19 NLRIYKNIYKQSIEEPSKFWDRIAESLIDWFEP-----WKKTFVQEEG-LLTKWFVEGKL 72
Query: 80 NVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDR 139
N YN +DR+ + K A WE + +TY+ L V ++AN L G+RKGDR
Sbjct: 73 NASYNAIDRHAFSNRKFKAAIIWESGKHERRV-LTYQDLYYEVNRWANALREIGVRKGDR 131
Query: 140 VAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGER 199
V +YMP+ E VI MLA R+GA+H VVFAGF ALA+R+SDA +K+++TAD +R +
Sbjct: 132 VTIYMPLTPEGVISMLAVTRLGAIHNVVFAGFGVQALADRISDAGSKVVITADAYYRRGK 191
Query: 200 MYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIWWH 259
+ K+ D++I R K+ + +++V SEI ++++ D+++
Sbjct: 192 LVELKKAVDESI---RLLGKN--------SPVEKVIIYKRTGSEIP----FDDKRDVYFE 236
Query: 260 EVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDY-HR 318
E+ + + PE V + PL++LYTSG+TGKPKG+VH+TAGYL+ + + +
Sbjct: 237 EIAKYKP--IDPEPVESTHPLYILYTSGTTGKPKGIVHSTAGYLVGTSIMLLWSYGMSEE 294
Query: 319 RDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTA 378
D+ + T+D+GW+ GH+Y+ YAPL + V++E P +P D++ II + +VT F T+
Sbjct: 295 NDILFNTSDIGWVVGHSYITYAPLVMGRSIVIYEDAPDYPYADKWAEIIERNRVTVFGTS 354
Query: 379 PTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFW 438
TA+R+ M + D + DLSSLRV+ + GEP+N A W W +G R + +W
Sbjct: 355 ATALRSFMKY---GDEVVKKHDLSSLRVIVTAGEPLNYAPWKWGLEVVGNGRVYMSHQWW 411
Query: 439 QTETGGHVITGLPGA--TPMKPG 459
QTETG + +PG PMK G
Sbjct: 412 QTETGSPNLGYMPGLIYLPMKSG 434
Score = 168 bits (408), Expect = 5e-40
Identities = 89/218 (40%), Positives = 128/218 (58%), Gaps = 5/218 (2%)
Query: 487 IVHLPNKSNRTRGFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWP-GMMRTLLED--QD 543
+++LP KS T GFP G + +IL+E G + GYLV P+P MM + D +
Sbjct: 426 LIYLPMKSGPTCGFPLPGNKIEILDESGNTTKPRNRGYLVMLPPYPPSMMIGMWNDPGNE 485
Query: 544 RFERVYFSKFPGYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRV 603
R ++ YFSKFPG Y +GD DE+GY+W+ GR D+ + V+ H + EVE + S P V
Sbjct: 486 RLKKSYFSKFPGIYYSGDYAMIDEEGYIWVMGRADETIKVAAHRIGAGEVESITTSHPAV 545
Query: 604 SEAAVVPKPHEVKGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGL 663
+EAA + P VKGE ++ FVVLK G +L + +R +GA P+ I L
Sbjct: 546 AEAAAIGLPDPVKGENIHIFVVLKTGHVPSQELATEIQAYMRGHMGAIVTPE-IHFVEKL 604
Query: 664 PKTRSGKIMRRILRKIAVGDHEVGDISTLADPGVVEEL 701
PKTRSGK+MRR+++ + +G GDIST+ D +EE+
Sbjct: 605 PKTRSGKVMRRVIKAVMLG-QSTGDISTIEDETSMEEI 641
>UniRef50_Q6LEZ6 Cluster: Acetyl-coenzyme a synthetase; n=3;
Plasmodium|Rep: Acetyl-coenzyme a synthetase -
Plasmodium falciparum (isolate 3D7)
Length = 997
Score = 266 bits (651), Expect = 2e-69
Identities = 120/207 (57%), Positives = 149/207 (71%), Gaps = 3/207 (1%)
Query: 255 DIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVF 314
DI +L+ + CP E+V +ED LF+LYTSGSTGKPKGV HTTAGYL+YA T +Y+F
Sbjct: 526 DIDGTALLKNMRSYCPIEYVDSEDFLFLLYTSGSTGKPKGVAHTTAGYLLYAYTTCKYIF 585
Query: 315 DYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQ 374
D D++ C AD+GW+TGHTYV+Y PL N T+V+F P +P RYWS+I +KVTQ
Sbjct: 586 DVKENDIFGCVADIGWVTGHTYVLYGPLLNGITTVIFSSIPTYPDCGRYWSLIQTHKVTQ 645
Query: 375 FYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIV 434
FYTAPTA+RALM + D + DLSS R+LGSVGEPINP W WYY +GK++C+IV
Sbjct: 646 FYTAPTALRALMKY---GDEWIQKYDLSSCRILGSVGEPINPETWRWYYNVVGKKKCTIV 702
Query: 435 DTFWQTETGGHVITGLPGATPMKPGAA 461
DT+WQTETGG VI +P MKPG A
Sbjct: 703 DTYWQTETGGIVIAPIPHLFSMKPGCA 729
Score = 142 bits (344), Expect = 3e-32
Identities = 75/197 (38%), Positives = 118/197 (59%), Gaps = 10/197 (5%)
Query: 18 LPSIQKYKEMYERSLTESELFWTEVAQE-FQWHVAPKPGGFMK-YNFDITKGRVFVKFME 75
+ + Q YK MYE S+ E FW +A+ W+ F K + + KG + +
Sbjct: 53 IKNFQAYKAMYEESINNPEAFWGNLAKNNLIWYKL-----FTKVFLGNFKKGNI--NWFV 105
Query: 76 EAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIR 135
++N C N +DR V+ +KIA WE + PD Y +ITY+KLL+ C+ AN L G++
Sbjct: 106 NGKINACENCVDRWVEKD-PNKIALIWEQDCPDQYKKITYQKLLEKTCKVANLLKLIGVK 164
Query: 136 KGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAW 195
K D V +Y+PMI E + MLAC RIGA+H VVFAG+S+ +L++R+ D+++ +L+T+D
Sbjct: 165 KQDTVTIYLPMIPELIYSMLACVRIGAIHNVVFAGYSAASLSDRIIDSRSTVLITSDFGL 224
Query: 196 RGERMYVYKRTCDDAIE 212
RG ++ K+ D A++
Sbjct: 225 RGGKLTKLKQIADVAMD 241
Score = 134 bits (323), Expect = 1e-29
Identities = 67/145 (46%), Positives = 87/145 (60%), Gaps = 2/145 (1%)
Query: 487 IVHLPNKSNRTRGFPFFGVEPKILNEDGVE-IEGPGE-GYLVFARPWPGMMRTLLEDQDR 544
I HL + PF GV+ +IL+ ++ + G G L PWPGM+RT+ + R
Sbjct: 718 IPHLFSMKPGCASLPFLGVQLEILDSKTLQPLSGNNVCGLLCIKSPWPGMLRTVYGNHQR 777
Query: 545 FERVYFSKFPGYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVS 604
+ YF+ P YY TGDG RDEDGY WI+GRIDD LNV+GH + AE+E L ++
Sbjct: 778 LIKTYFTMCPNYYFTGDGAFRDEDGYYWISGRIDDTLNVAGHRLGAAEIEHALVQHFYIA 837
Query: 605 EAAVVPKPHEVKGEALYCFVVLKEG 629
EAAVV H VKGE + CFVV K+G
Sbjct: 838 EAAVVSFHHNVKGEGILCFVVKKKG 862
Score = 75.4 bits (177), Expect = 5e-12
Identities = 43/80 (53%), Positives = 52/80 (65%), Gaps = 1/80 (1%)
Query: 633 DADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKIAVGDHEVGDISTL 692
D L++ L L VRQ IG A PD I P LPKTRSGKI+RRILR IA G + GDIST+
Sbjct: 911 DEKLIEQLKLYVRQVIGPIATPDLICVVPDLPKTRSGKIVRRILRCIANGITDFGDISTV 970
Query: 693 ADPGVVEELFNNRPAEAKPK 712
++ V+E + NN E K K
Sbjct: 971 SNYEVIETI-NNTLIECKKK 989
>UniRef50_A5K2B0 Cluster: Acetyl-CoA synthetase, putative; n=1;
Plasmodium vivax|Rep: Acetyl-CoA synthetase, putative -
Plasmodium vivax
Length = 1053
Score = 264 bits (647), Expect = 6e-69
Identities = 119/210 (56%), Positives = 146/210 (69%), Gaps = 3/210 (1%)
Query: 252 EETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFR 311
E D+ +++ CP E+V +ED L +LYTSGSTGKPKGV HTTAGYL+YA T +
Sbjct: 570 EGRDVDGSALIKNMRAYCPIEYVDSEDFLCLLYTSGSTGKPKGVAHTTAGYLLYAYTTCK 629
Query: 312 YVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYK 371
Y+FD D++ C AD+GW+TGHTYV+Y PL N T+V+F P +P RYWS+I +K
Sbjct: 630 YIFDVTADDIFGCVADIGWVTGHTYVLYGPLLNGITTVLFSSIPTYPDCGRYWSLIETHK 689
Query: 372 VTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERC 431
VTQFYTAPTA+RALM H D + DLSS R+LGSVGEPINP W WYY +GK +C
Sbjct: 690 VTQFYTAPTALRALMKH---GDSYIEKYDLSSCRILGSVGEPINPETWRWYYNTVGKRKC 746
Query: 432 SIVDTFWQTETGGHVITGLPGATPMKPGAA 461
IVDT+WQTETGG VI +P MKPG A
Sbjct: 747 VIVDTYWQTETGGIVIAPIPNLFKMKPGCA 776
Score = 150 bits (363), Expect = 1e-34
Identities = 79/197 (40%), Positives = 120/197 (60%), Gaps = 10/197 (5%)
Query: 18 LPSIQKYKEMYERSLTESELFWTEVAQE-FQWHVAPKPGGFMK-YNFDITKGRVFVKFME 75
+ + YKEMYE S+ ELFW +A+ +W F K Y + KG + +
Sbjct: 53 IKDVSIYKEMYEESINNPELFWGNIAKNSVRWFKL-----FTKVYIGNFKKGNI--SWFV 105
Query: 76 EAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIR 135
++N C N +DR V+ +KIA WE ++P+D+ +ITY+KLL+ C+ AN L G++
Sbjct: 106 NGKINACDNCVDRWVEK-HPNKIAIIWEKDTPNDFKKITYQKLLERTCKIANLLKMYGVK 164
Query: 136 KGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAW 195
K D V +Y+PMI E V MLACARIGA+H VVFAG+S+ +L +R+ D+ + +L+T+D
Sbjct: 165 KQDVVTIYLPMIPEIVYTMLACARIGAIHNVVFAGYSAGSLCDRILDSNSSVLITSDFGM 224
Query: 196 RGERMYVYKRTCDDAIE 212
RG ++ K+ D A+E
Sbjct: 225 RGGKLTKLKQIADAAME 241
Score = 144 bits (349), Expect = 7e-33
Identities = 73/151 (48%), Positives = 93/151 (61%), Gaps = 5/151 (3%)
Query: 485 VMIVHLPNKSNRTRG---FPFFGVEPKILNEDGVE-IEGPGE-GYLVFARPWPGMMRTLL 539
++I +PN G PFFGV+ +IL+ +E + GP G L PWPGM+RT+
Sbjct: 760 IVIAPIPNLFKMKPGCASLPFFGVQLEILDSKTLEPLNGPNVCGLLCIKSPWPGMLRTVY 819
Query: 540 EDQDRFERVYFSKFPGYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLAS 599
+ +R + YFS P YY TGDG RDEDGY WI+GRIDD LNVSGH + AE+E L
Sbjct: 820 GNHNRLVKTYFSSCPNYYFTGDGAYRDEDGYYWISGRIDDTLNVSGHRLGAAEIEHALVQ 879
Query: 600 DPRVSEAAVVPKPHEVKGEALYCFVVLKEGL 630
++EAAVV H VKGE + CFVV K G+
Sbjct: 880 HSCIAEAAVVSFRHVVKGEGILCFVVKKVGV 910
Score = 68.9 bits (161), Expect = 4e-10
Identities = 38/83 (45%), Positives = 55/83 (66%), Gaps = 1/83 (1%)
Query: 633 DADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKIAVGDHEVGDISTL 692
D ++++ L L VR+ IG A PD I P LPKTRSGKI+RRILR IA ++ GDI+T+
Sbjct: 970 DENIIEELKLYVRRAIGPIATPDLICIVPDLPKTRSGKIIRRILRCIANELNDFGDITTV 1029
Query: 693 ADPGVVEELFNN-RPAEAKPKTG 714
A+ V++ + N R ++ K + G
Sbjct: 1030 ANHEVIDIIVNKFRDSKLKCQLG 1052
>UniRef50_Q7RL40 Cluster: Acetate--CoA ligase-related; n=3;
Plasmodium (Vinckeia)|Rep: Acetate--CoA ligase-related -
Plasmodium yoelii yoelii
Length = 951
Score = 261 bits (639), Expect = 5e-68
Identities = 118/210 (56%), Positives = 147/210 (70%), Gaps = 3/210 (1%)
Query: 252 EETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFR 311
E DI +++ CP E+V +ED L +LYTSGSTGKPKGV HTTAGYL+YA AT +
Sbjct: 487 EGRDINGSMLMKNMRPYCPIEYVDSEDFLSILYTSGSTGKPKGVTHTTAGYLLYAFATSK 546
Query: 312 YVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYK 371
Y+FD D++ C AD+GW+TGHTYVVY PL N T+ +F P +P RYW++I +K
Sbjct: 547 YIFDIKDDDIFGCVADIGWVTGHTYVVYGPLLNGITTTLFSSIPTYPDCSRYWNLIQTHK 606
Query: 372 VTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERC 431
+TQFYTAPTA+R LM H D + DLSS R+LGSVGEPINP W WYY +GK++C
Sbjct: 607 ITQFYTAPTALRTLMKH---GDYYIKNYDLSSCRILGSVGEPINPETWRWYYNVVGKKKC 663
Query: 432 SIVDTFWQTETGGHVITGLPGATPMKPGAA 461
IVDT+WQTETGG VI +P MKPG+A
Sbjct: 664 VIVDTYWQTETGGIVIAPIPHLFKMKPGSA 693
Score = 148 bits (359), Expect = 4e-34
Identities = 79/197 (40%), Positives = 122/197 (61%), Gaps = 10/197 (5%)
Query: 18 LPSIQKYKEMYERSLTESELFWTEVAQE-FQWHVAPKPGGFMK-YNFDITKGRVFVKFME 75
+ I++YK+MYE S+ ELFW ++A+ +W F K Y + KG V +
Sbjct: 53 IKDIKEYKKMYEESIKNPELFWGDMAKNNLRWSKL-----FTKTYIGNFNKGNV--SWFV 105
Query: 76 EAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIR 135
++N C N +DR V+ +K A WE ++P+DY +I+Y+KLL+ VC+ AN L G++
Sbjct: 106 NGKINACDNCVDRWVEK-HPNKTAIIWEKDTPNDYKKISYQKLLEKVCKIANLLKMYGVK 164
Query: 136 KGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAW 195
K D V +Y+PMI E + MLACARIGA+H VVFAG+S+ +L+ER+ + + +L+T+D
Sbjct: 165 KQDCVTIYLPMIPELIYSMLACARIGAIHNVVFAGYSTRSLSERIVSSGSTILITSDFGL 224
Query: 196 RGERMYVYKRTCDDAIE 212
RG ++ K D A+E
Sbjct: 225 RGGKLTKLKNIADGAME 241
Score = 140 bits (340), Expect = 9e-32
Identities = 69/143 (48%), Positives = 88/143 (61%), Gaps = 2/143 (1%)
Query: 487 IVHLPNKSNRTRGFPFFGVEPKILNEDGVE-IEGPGE-GYLVFARPWPGMMRTLLEDQDR 544
I HL + PFFG++ +ILN +E ++GP G L WPGM+RT+ + +R
Sbjct: 682 IPHLFKMKPGSASLPFFGIQLEILNSKTLEPLKGPNVCGILCIKSSWPGMLRTVYGNHNR 741
Query: 545 FERVYFSKFPGYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVS 604
+ YF P YY TGDG RDEDGY WI+GRIDD LNVSGH + AE+E L +S
Sbjct: 742 LIKTYFEACPSYYFTGDGAYRDEDGYYWISGRIDDTLNVSGHRLGAAEIEHALVQHSCIS 801
Query: 605 EAAVVPKPHEVKGEALYCFVVLK 627
E+AVV H+VKGE + CFVV K
Sbjct: 802 ESAVVSFSHKVKGEGILCFVVKK 824
Score = 77.4 bits (182), Expect = 1e-12
Identities = 41/80 (51%), Positives = 55/80 (68%), Gaps = 1/80 (1%)
Query: 633 DADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKIAVGDHEVGDISTL 692
D L++ L L VR+ IG A PD I P LPKTRSGKI+RRILR IA+G ++ GDIST+
Sbjct: 867 DEKLIEELKLYVRKVIGPIATPDIICIVPDLPKTRSGKIIRRILRAIAIGLNDYGDISTV 926
Query: 693 ADPGVVEELFNNRPAEAKPK 712
++ V+ E+ N+ E+K K
Sbjct: 927 SNYDVI-EIIKNKFMESKEK 945
>UniRef50_A7RH51 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 696
Score = 261 bits (639), Expect = 5e-68
Identities = 151/422 (35%), Positives = 229/422 (54%), Gaps = 32/422 (7%)
Query: 24 YKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRVFVKFMEEAELNVCY 83
Y E +++S+ + E FW +VAQ W+ KP + K + T F K+ ELN C+
Sbjct: 57 YDEAFKQSVEDPEGFWDDVAQGIDWY---KP--YTKVVDNATPP--FTKWFPGGELNTCF 109
Query: 84 NLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAVY 143
N LDR+++NG G +IA ++ +Y+ L LV +FA L + + KGDRV +Y
Sbjct: 110 NCLDRHIENGIGGRIALIYDSPVSGKIEMYSYQNLQRLVAKFAGALNSLNVGKGDRVVIY 169
Query: 144 MPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGERMYVY 203
MPM+ +AVI MLACARIGA+H+VVF GF++ LA R+ A+ +++VTA R+ Y
Sbjct: 170 MPMVPQAVIAMLACARIGAIHSVVFGGFAAAELARRIEHAEPRVIVTASCGIEPSRIVTY 229
Query: 204 KRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIWWHEVLE 263
K D+AI K +F V + + PG DI W +V+E
Sbjct: 230 KPLVDEAI-KISSFKPSTVVLYQRDQCTGDIIPG----------------RDITWDQVME 272
Query: 264 -GESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVY 322
E + C P V A DPL++LYTSG+TG PKG+V G+ + + + ++ + +V+
Sbjct: 273 RAEPHDCVP--VLATDPLYILYTSGTTGDPKGIVRRNGGHAVALNWSMKNIYGVNPGEVW 330
Query: 323 WCTADVGWITGHTYVVYAPLANAATSVMFEGTPY-FPKVDRYWSIINKYKVTQFYTAPTA 381
W +D+GW+ GH+Y+VYAPL N T+V+FEG P P ++ +I ++KV +TAPTA
Sbjct: 331 WAASDLGWVVGHSYIVYAPLFNGCTTVLFEGKPVGTPDAGAFFRVIEQHKVISMFTAPTA 390
Query: 382 IRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTE 441
IR + + + + DLS R + GE ++ W I + D +WQTE
Sbjct: 391 IRIIRTE-DPKAELIRQYDLSHFRDMFLAGEHLDKDTMQWARRAIS---APVYDNWWQTE 446
Query: 442 TG 443
+G
Sbjct: 447 SG 448
Score = 123 bits (297), Expect = 1e-26
Identities = 81/223 (36%), Positives = 112/223 (50%), Gaps = 8/223 (3%)
Query: 466 PVYYSSMDTFRPKQGWDRTVMIVHLPNKSNR---TRGFPFFGVEPKILNEDGVEIEGPGE 522
PVY + T + GW T V L + T G G KIL ED E +
Sbjct: 437 PVYDNWWQT---ESGWAITAHTVGLGRPMDEKLETTGKAVPGYNVKILREDMTEADRGEL 493
Query: 523 GYLVFARPWP-GMMRTLLEDQDRFERVYFSKFPGYYCTGDGVRRDEDGYLWITGRIDDML 581
G + P P G M TL +RF++ YF K+PGYY + D DEDGY+ I R DD++
Sbjct: 494 GQICVKLPMPPGTMGTLWRADERFKKTYFEKYPGYYDSSDAGVMDEDGYVSIMARTDDVI 553
Query: 582 NVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALYCFVVLKEGLQF-DADLVKTL 640
NV+GH +ST +E + V +AA + +KG FV++ + + D++K +
Sbjct: 554 NVAGHRISTKSLEEGMMKPSFVVDAACIGLKDGIKGHVPLGFVIVDKTVSMKKEDMIKEV 613
Query: 641 TLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKIAVGD 683
VR+ +G AA T P LPKTRSGK +R IL KI G+
Sbjct: 614 KKSVREFVGPVAAFKTAVIVPALPKTRSGKTVRGILAKIVHGE 656
>UniRef50_Q5QYS0 Cluster: Propionyl-CoA synthetase; n=1; Idiomarina
loihiensis|Rep: Propionyl-CoA synthetase - Idiomarina
loihiensis
Length = 623
Score = 254 bits (623), Expect = 5e-66
Identities = 154/456 (33%), Positives = 245/456 (53%), Gaps = 35/456 (7%)
Query: 21 IQKYKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRVFVKFMEEAELN 80
+Q YK +Y + + E FW E A+ W PK +K N + + E+N
Sbjct: 1 MQAYKNVYSEAQQDPEGFWLEQARRLNWFKTPKVAAQVKKNG-------LADWFPDGEVN 53
Query: 81 VCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRV 140
+ Y LD ++ G G+++A +++ T+ +L + V FA+ L +G+ KGDRV
Sbjct: 54 ISYLALDAQIEAGRGEQVALYYDSPVTQSKANYTFNQLREQVACFAHVLKQQGVEKGDRV 113
Query: 141 AVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGERM 200
+Y+PMI +A I MLACARIGA+H+VVF GF++ LA R+ DA KL++TA G ++
Sbjct: 114 IIYLPMIPQAAIAMLACARIGAIHSVVFGGFAAHELAVRIDDAAPKLIITASCGIEGTKV 173
Query: 201 YVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIWWHE 260
YK D A+ +A +K R +V ++ ++E+++ ++TD W +
Sbjct: 174 LPYKPIVDKALAEAT--YKPRT----IVYQREQ------CQAEMQE----GQDTD--WEQ 215
Query: 261 VLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRD 320
L S + + A PL++LYTSG+TGKPKGVV GY + + YV+ +
Sbjct: 216 ALTTASPL-EAIPLPATHPLYILYTSGTTGKPKGVVRDHGGYAVALNFSMNYVYGLEPGE 274
Query: 321 VYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPY-FPKVDRYWSIINKYKVTQFYTAP 379
V++ +DVGW+ GH+Y+VY PL +SV++EG P P +W I+ Y V+ ++AP
Sbjct: 275 VFFTASDVGWVVGHSYIVYGPLLFGCSSVLYEGKPVNTPDAGAFWRIVQDYNVSAIFSAP 334
Query: 380 TAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQ 439
TA RA+ + E + DLSSL+ + GE ++PA + W T + + D +WQ
Sbjct: 335 TAFRAIKKE-DPEGEFIQRYDLSSLKRIYMAGERLDPATYEW-TTEL--TDLPVYDHWWQ 390
Query: 440 TETGGHVI---TGLPGATPMKPGAAEKKHPVYYSSM 472
TE+G + G+ GA +KPG++ P Y S+
Sbjct: 391 TESGWPMCANPVGI-GAVKVKPGSSTFPVPGYEISV 425
Score = 154 bits (373), Expect = 9e-36
Identities = 84/204 (41%), Positives = 120/204 (58%), Gaps = 3/204 (1%)
Query: 500 FPFFGVEPKILNEDGVEIEGPGEGYLVFARPWP-GMMRTLLEDQDRFERVYFSKFPGYYC 558
FP G E +L+ G + EG + P P G + T+ D+ R Y + FPGYYC
Sbjct: 416 FPVPGYEISVLDPLGKGLGSKEEGAICVRLPLPPGCLTTVWGDEQRLHSSYLNAFPGYYC 475
Query: 559 TGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGE 618
+GDG DE GY++I GR DD++NV+GH +ST E+E +LA+ V+E AVV +P E+KGE
Sbjct: 476 SGDGGYIDEQGYVFIMGRTDDVINVAGHRLSTGEMEEILAAHKDVAECAVVAQPDELKGE 535
Query: 619 ALYCFVVLKEGLQF-DADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILR 677
FV+LK L + L +R +IGA A T+ LPKTRSGKI+RR++R
Sbjct: 536 LPVGFVILKNSSTIAHEQLQQELIQSIRAEIGAIACLKTLHIVSRLPKTRSGKILRRLIR 595
Query: 678 KIAVGDHEVGDISTLADPGVVEEL 701
++ GD +V ST+ DP ++ +
Sbjct: 596 QVLQGD-DVAVPSTIDDPSSIDAI 618
>UniRef50_A5WC66 Cluster: Propionate--CoA ligase; n=3;
Psychrobacter|Rep: Propionate--CoA ligase -
Psychrobacter sp. PRwf-1
Length = 670
Score = 254 bits (621), Expect = 8e-66
Identities = 161/502 (32%), Positives = 252/502 (50%), Gaps = 61/502 (12%)
Query: 22 QKYKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRVFVKFMEEAELNV 81
+ + E+++ SL++ FW + A+ WH P+ D F K+ E N+
Sbjct: 14 ESFAELHQNSLSDPNAFWGKQAERIYWHKPPQQV------LD-DSNLPFAKWFVGGETNL 66
Query: 82 CYNLLDRNVKNGFGDKIAFFWEG---------NSPD----------------DYT--RIT 114
CYN +DR+++ ++ AF W N P DY R+T
Sbjct: 67 CYNCVDRHLE-ARAEQDAFVWVSSEINQELLDNHPGVAEAFKALDNHVEFYTDYAKRRLT 125
Query: 115 YRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSD 174
Y +L V FA+ L G+ KGDRV +YMPMILEA MLAC RIGA+H+VVF GF++
Sbjct: 126 YNRLYKEVNYFADVLQRLGVGKGDRVVIYMPMILEAAYAMLACTRIGAIHSVVFGGFAAH 185
Query: 175 ALAERLSDAKAKLLVTADGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRV 234
LA R+SDA+AKL++T D RG ++ YK + +E+A +H+ + +VV DR
Sbjct: 186 NLAVRMSDAEAKLVITVDAGLRGGKVINYKNLVNQGVEQA----EHKPEHVLVV---DR- 237
Query: 235 TPGGSLKSEIKDLYNWNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKG 294
G + E + + + T+ + + P W+ + +P ++LYTSG+TG PKG
Sbjct: 238 ---GIMPYE-RQAIDVDYATE---RRISCDNRAVVEPVWLESNEPSYLLYTSGTTGTPKG 290
Query: 295 VVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGT 354
V T GY + T Y++D + + +W +D+GW GH+Y +YAPL TS+M+EG
Sbjct: 291 VQRDTGGYAVALTTTMDYIYDGNPGETFWAISDIGWAVGHSYTIYAPLLAGLTSIMYEGL 350
Query: 355 PYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPI 414
P+ P +W I+ KV +TAPT +R L ++ LT D SS++ GEP+
Sbjct: 351 PHNPNPGIWWRIVEANKVNILFTAPTGVRMLKKQ---DESWLTRYDTSSVKSFFLAGEPL 407
Query: 415 NPAAWLWYYTRIGKERCSIVDTFWQTETGGHVITGLP-----GATPMKPGAAEKKHPVYY 469
+ W +G I+D +WQTETG +++ +P P PG +
Sbjct: 408 DEPTGEWLSGHLG---VPIIDHYWQTETGWPILSHVPKFDYKAHRPGTPGYPMYGYDAKV 464
Query: 470 SSMDTFRPKQGWDRTVMIVHLP 491
+ +T P Q ++ ++ + P
Sbjct: 465 LNEETGEPCQPGEKGLLAISAP 486
Score = 145 bits (351), Expect = 4e-33
Identities = 85/235 (36%), Positives = 130/235 (55%), Gaps = 11/235 (4%)
Query: 475 FRPKQGWDRTVMIVHLPNKSNR--TRGFPFFGVEPKILNEDGVEIEGPGE-GYLVFARPW 531
++ + GW + K++R T G+P +G + K+LNE+ E PGE G L + P
Sbjct: 428 WQTETGWPILSHVPKFDYKAHRPGTPGYPMYGYDAKVLNEETGEPCQPGEKGLLAISAPL 487
Query: 532 P-GMMRTLLEDQDRFERVYFSKFPG-YYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMS 589
P G + T+ + +RF + Y+S F G Y + D DEDGY I GR DD++NV+GH +
Sbjct: 488 PPGCLTTVWRNDERFMKSYYSLFNGKQYSSSDYAMIDEDGYYHILGRTDDVINVAGHRLG 547
Query: 590 TAEVEGVLASDPRVSEAAVVPKPHEVKGEALYCFVVLKEGLQFDAD-----LVKTLTLLV 644
T E+E ++ P V+E VV E+KGE F +L++ + + + + +V
Sbjct: 548 TQEIEAAISEHPEVAEVGVVGIKDELKGELPIAFCILRDPSVIEETENRFRVEQQIMGVV 607
Query: 645 RQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKIAVGDHEVGDISTLADPGVVE 699
+ +GA A P I LPKTRSGKI+RR +R +A G + GD+STL DP ++
Sbjct: 608 AKSLGALARPAAIYFPKALPKTRSGKILRRAIRALAEG-QDTGDMSTLDDPTAID 661
>UniRef50_Q9H6R3 Cluster: CDNA: FLJ21963 fis, clone HEP05583; n=30;
cellular organisms|Rep: CDNA: FLJ21963 fis, clone
HEP05583 - Homo sapiens (Human)
Length = 686
Score = 250 bits (612), Expect = 1e-64
Identities = 154/452 (34%), Positives = 241/452 (53%), Gaps = 36/452 (7%)
Query: 23 KYKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRVFVKFMEEAELNVC 82
+YK + S+T+ E FW + A++ W+ KP N R FV+ M LN+C
Sbjct: 61 EYKTHFAASVTDPERFWGKAAEQISWY---KPWTKTLENKHSPSTRWFVEGM----LNIC 113
Query: 83 YNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAV 142
YN +DR+++NG GDKIA ++ + TY+++L+ V + A L+ GI+KGD V +
Sbjct: 114 YNAVDRHIENGKGDKIAIIYDSPVTNTKATFTYKEVLEQVSKLAGVLVKHGIKKGDTVVI 173
Query: 143 YMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTAD-GAWRGERM- 200
YMPMI +A+ MLACARIGA+H+++F GF+S L+ R+ K K++VTA G G R+
Sbjct: 174 YMPMIPQAMYTMLACARIGAIHSLIFGGFASKELSSRIDHVKPKVVVTASFGIEPGRRVE 233
Query: 201 YVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIWWHE 260
YV +E+A +H+ D ++ N R + +DL +W+E E
Sbjct: 234 YV------PLVEEALKIGQHKPDKILIYN---RPNMEAVPLAPGRDL-DWDE-------E 276
Query: 261 VLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRD 320
+ + +S+ C P V +E PL++LYTSG+TG PKGV+ T GY + + ++ +
Sbjct: 277 MAKAQSHDCVP--VLSEHPLYILYTSGTTGLPKGVIRPTGGYAVMLHWSMSSIYGLQPGE 334
Query: 321 VYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPY-FPKVDRYWSIINKYKVTQFYTAP 379
V+W +D+GW+ GH+Y+ Y PL + T+V++EG P P Y+ ++ ++ V +TAP
Sbjct: 335 VWWAASDLGWVVGHSYICYGPLLHGNTTVLYEGKPVGTPDAGAYFRVLAEHGVAALFTAP 394
Query: 380 TAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQ 439
TAIRA+ + L+ + L GE + W R ++D +WQ
Sbjct: 395 TAIRAI-RQQDPGAALGKQYSLTRFKTLFVAGERCDVETLEWSKNVF---RVPVLDHWWQ 450
Query: 440 TETGGHV---ITGLPGATPMKPGAAEKKHPVY 468
TETG + GL + PG A K P Y
Sbjct: 451 TETGSPITASCVGLGNSKTPPPGQAGKSVPGY 482
Score = 113 bits (273), Expect = 1e-23
Identities = 73/203 (35%), Positives = 108/203 (53%), Gaps = 6/203 (2%)
Query: 504 GVEPKILNEDGVEIEGPGEGYLVFARPWP-GMMRTLLEDQDRFERVYFSKFPGYYCTGDG 562
G IL+++ +++ G +V P P G L ++Q+ F+ +YF KFPGYY T D
Sbjct: 481 GYNVMILDDNMQKLKARCLGNIVVKLPLPPGAFSGLWKNQEAFKHLYFEKFPGYYDTMDA 540
Query: 563 VRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALYC 622
DE+GYL++ R+DD++NV+GH +S +E + S V++ AVV K +KG
Sbjct: 541 GYMDEEGYLYVMSRVDDVINVAGHRISAGAIEESILSHGTVADCAVVGKEDPLKGHVPLA 600
Query: 623 FVVLKEGLQ-FDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKIAV 681
VL++ + + +++ + VRQ IG AA LPKTRSGKI R L I V
Sbjct: 601 LCVLRKDINATEEQVLEEIVKHVRQNIGPVAAFRNAVFVKQLPKTRSGKIPRSALSAI-V 659
Query: 682 GDHEVGDISTLADP---GVVEEL 701
ST+ DP G VEE+
Sbjct: 660 NGKPYKITSTIEDPSIFGHVEEM 682
>UniRef50_Q4ST59 Cluster: Chromosome undetermined SCAF14300, whole
genome shotgun sequence; n=1; Tetraodon
nigroviridis|Rep: Chromosome undetermined SCAF14300,
whole genome shotgun sequence - Tetraodon nigroviridis
(Green puffer)
Length = 737
Score = 248 bits (608), Expect = 3e-64
Identities = 112/186 (60%), Positives = 140/186 (75%), Gaps = 8/186 (4%)
Query: 281 FVLYTSGSTG-----KPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHT 335
F L+T G G +GV+HT +GY++Y AATF+ VFD+ DV+WCTAD+GWITGH+
Sbjct: 236 FELFTCGLQGFDLPASSQGVLHTVSGYMLYTAATFKLVFDHQPDDVFWCTADIGWITGHS 295
Query: 336 YVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGN 395
Y+ Y PLAN ATSV+FEG P +P V R W I++KY+VT+FYTAPTAIR LM Y E
Sbjct: 296 YITYGPLANGATSVLFEGLPTYPDVSRMWEIVDKYQVTKFYTAPTAIRMLM-KYGSEPVQ 354
Query: 396 LTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTETGGHVITGLPGATP 455
T SL++LG+VGEPINP AW WY+T +G++RC IVDTFWQTETGGHV+T LP ATP
Sbjct: 355 KT--GRESLKILGTVGEPINPEAWQWYHTVVGEKRCPIVDTFWQTETGGHVLTPLPVATP 412
Query: 456 MKPGAA 461
+KPG+A
Sbjct: 413 LKPGSA 418
Score = 199 bits (486), Expect = 2e-49
Identities = 98/177 (55%), Positives = 120/177 (67%), Gaps = 7/177 (3%)
Query: 462 EKKHPVYYSSMDTFRPKQ--GWDRTVMIVHLPNKSNRTRGFPFFGVEPKILNEDGVEIEG 519
EK+ P+ +DTF + G T + V P K PFFGV P ILNE G E+EG
Sbjct: 385 EKRCPI----VDTFWQTETGGHVLTPLPVATPLKPGSAT-LPFFGVVPAILNESGEELEG 439
Query: 520 PGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYCTGDGVRRDEDGYLWITGRIDD 579
EGYLVF +PWPG+MRT+ + RF+ YF KFPGYY TGDG RRD+DGY WITGRIDD
Sbjct: 440 ETEGYLVFKQPWPGVMRTVYGNHQRFQTTYFKKFPGYYVTGDGCRRDKDGYYWITGRIDD 499
Query: 580 MLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALYCFVVLKEGLQFDADL 636
MLNVSGHL+ST++VE L V+EAAVV +PH +KGE+LYCFV L +G+ + L
Sbjct: 500 MLNVSGHLLSTSQVESALVEHEAVAEAAVVGRPHPIKGESLYCFVTLTQGVTYSRAL 556
Score = 195 bits (475), Expect = 4e-48
Identities = 89/167 (53%), Positives = 124/167 (74%), Gaps = 2/167 (1%)
Query: 74 MEEAELNVCYNLLDRNV-KNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAK 132
M+ A N+CYN+LDRNV + GDK+AF+WEGN P D +TYR+LL VCQFAN L ++
Sbjct: 1 MDGASTNICYNVLDRNVHEKKLGDKVAFYWEGNEPGDELTVTYRELLQRVCQFANVLKSR 60
Query: 133 GIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTAD 192
G++KGDRV++YMPM++E V+ MLACARIGAVH++VFAGFSS++L ER+ D++ LL+TAD
Sbjct: 61 GVKKGDRVSIYMPMVVELVVAMLACARIGAVHSIVFAGFSSESLCERILDSQCCLLITAD 120
Query: 193 GAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGS 239
G +RG+++ K D+A++K R + C+V+ HL R GGS
Sbjct: 121 GFYRGDKLINLKVLADEALQKCRD-NGFLLQNCIVLKHLSREPRGGS 166
>UniRef50_Q0JDG8 Cluster: Os04g0404800 protein; n=8; cellular
organisms|Rep: Os04g0404800 protein - Oryza sativa
subsp. japonica (Rice)
Length = 810
Score = 248 bits (608), Expect = 3e-64
Identities = 118/271 (43%), Positives = 174/271 (64%), Gaps = 10/271 (3%)
Query: 23 KYKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRVFVKFMEEAELNVC 82
+Y+EMY RS+ + FW+E+A+ F W P N D+TKG + +++ + + N+C
Sbjct: 220 QYQEMYRRSIDDPAGFWSEIAETFYWKHKWNPDEVCTENLDVTKGPIKIEWFKGGKTNIC 279
Query: 83 YNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAV 142
YN +DRNV+ G G+KIA +WEGN P ++TY +LL+ VCQ AN L + G+ KGD V +
Sbjct: 280 YNAVDRNVEAGDGEKIAMYWEGNEPGQDAKLTYSELLNKVCQLANYLKSVGVGKGDAVVI 339
Query: 143 YMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGERMYV 202
Y+PM++E I MLACARIGAVH+VVFAGFS+DALA+R+ D K K+++T + RG+++
Sbjct: 340 YLPMLMELPIAMLACARIGAVHSVVFAGFSADALAQRIIDCKPKVVITCNAVKRGKKLIA 399
Query: 203 YKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIWWHEVL 262
K D ++ + K+ VD+ + + + ++ ++K E W D+WW +V+
Sbjct: 400 LKDIVDVSLADSA---KNGVDVGISLTYENQ----SAMKREDT---KWTSGRDVWWQDVV 449
Query: 263 EGESNICPPEWVAAEDPLFVLYTSGSTGKPK 293
C EWV AEDPLF+LYTSGSTGKPK
Sbjct: 450 PNFPTKCDVEWVDAEDPLFLLYTSGSTGKPK 480
Score = 237 bits (579), Expect = 1e-60
Identities = 120/218 (55%), Positives = 150/218 (68%), Gaps = 16/218 (7%)
Query: 500 FPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYCT 559
FPFFGV+P I++E G E+EG GYL + WPG RTL D+DR+E YF F GYY +
Sbjct: 587 FPFFGVQPVIVDEKGKEMEGECSGYLCIKKSWPGAFRTLYGDKDRYETTYFKPFAGYYFS 646
Query: 560 GDGVRR---------------DEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVS 604
GDG R D+DGY ++TGR+DD++NVSGH + TAEVE L S P+ +
Sbjct: 647 GDGCSRITGCLHTGKCNLNARDKDGYHFLTGRVDDVINVSGHRIGTAEVESALVSHPKCA 706
Query: 605 EAAVVPKPHEVKGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLP 664
EAAVV HEVKG+ +Y FV L +G+ + +L K+L + VR +IGAFAAPD I APGLP
Sbjct: 707 EAAVVGIDHEVKGQGIYAFVTLVDGVPYSDELRKSLVMTVRSQIGAFAAPDKIHWAPGLP 766
Query: 665 KTRSGKIMRRILRKIAVGD-HEVGDISTLADPGVVEEL 701
KTRSGKIMRRILRKIA E+GD STLA+PGVV++L
Sbjct: 767 KTRSGKIMRRILRKIASRQLDELGDTSTLAEPGVVDQL 804
Score = 132 bits (320), Expect = 2e-29
Identities = 65/109 (59%), Positives = 75/109 (68%), Gaps = 7/109 (6%)
Query: 355 PYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGN--LTMPDLSSLRVLGSVGE 412
P +P R W +++KY VT FYTAPT IRALM DG +T SLRVLGSVGE
Sbjct: 482 PNYPDPSRCWDVVDKYGVTIFYTAPTLIRALM-----RDGTEYVTRYSRKSLRVLGSVGE 536
Query: 413 PINPAAWLWYYTRIGKERCSIVDTFWQTETGGHVITGLPGATPMKPGAA 461
PINP AW W+Y IG RC I DT+WQTETGG +IT LPGA P+KPG+A
Sbjct: 537 PINPTAWRWFYDIIGDARCPISDTWWQTETGGFMITPLPGAWPLKPGSA 585
>UniRef50_Q978X5 Cluster: Acetyl-CoA synthetase; n=3; cellular
organisms|Rep: Acetyl-CoA synthetase - Thermoplasma
volcanium
Length = 641
Score = 248 bits (606), Expect = 5e-64
Identities = 150/441 (34%), Positives = 241/441 (54%), Gaps = 40/441 (9%)
Query: 23 KYKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRV-FVKFMEEAELNV 81
++K + E S + FW +A + W K++ + +GR+ F + LNV
Sbjct: 25 EFKRLLEFSKNDPNGFWESIASDLVWR--------KKWD-TVMEGRLPEFSFFKGGYLNV 75
Query: 82 CYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVA 141
NL+DR+++ G ++ A +E + TY L +V + +N L + G++KGDRV+
Sbjct: 76 AENLIDRHIEAGEANRAALIFESETGRSAV-YTYAMLQSIVNKLSNALRSLGVKKGDRVS 134
Query: 142 VYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGERMY 201
+++P I E + +LAC R+GAV +F+GFS+ AL RL +++TADG +R ++
Sbjct: 135 IFLPNIPETLFSVLACYRVGAVFNTIFSGFSTQALENRLKHFNPMIIITADGTYRRGKLV 194
Query: 202 VYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIWWHEV 261
K+ D+ + + +VV ++ G +L N+ E D+ ++ +
Sbjct: 195 ELKKKVDEIRDS-------NFEKIIVVKNV-----GLNL--------NFTER-DLDFYSL 233
Query: 262 LEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDV 321
+ ++ V A +P V YTSG+TGKPKGVV + AG+L+ ++ D + DV
Sbjct: 234 IAKFNDKDKGGDVEANEPGIVFYTSGTTGKPKGVVLSGAGFLVNNYVYAKHHLDLSKSDV 293
Query: 322 YWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTA 381
WCTAD+GW+T H + + LAN +T++ +EG +P DR++ I+ KYKVT+ +TAPT
Sbjct: 294 LWCTADIGWLTMHIWGIIGALANGSTTLFYEGAIDYPSQDRFYEIVQKYKVTKIFTAPTL 353
Query: 382 IRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFW-QT 440
IR LM Y +G D+SS+RV+G VGEP+NP AW W R + ++ W QT
Sbjct: 354 IRMLM-KYGFPEGKY---DVSSVRVIGLVGEPLNPEAWHWMNKHF---RSAYINNTWGQT 406
Query: 441 ETGGHVITGLPGATPMKPGAA 461
ET G + G AT MKPG++
Sbjct: 407 ETAGTPLAGSAFATGMKPGSS 427
Score = 148 bits (358), Expect = 6e-34
Identities = 79/204 (38%), Positives = 122/204 (59%), Gaps = 4/204 (1%)
Query: 499 GFPFFGVEPKILNEDGVEI-EGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYY 557
G F G +++++G + E PG LV +P+P M+R L + +RF + Y+ K G Y
Sbjct: 428 GIEFLGASLDVVDDEGNPVLERPGN--LVIKKPFPMMIRDLWNEHERFLKEYYGKLEGLY 485
Query: 558 CTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKG 617
T D +D+DG+ W+ GR DD++NVSGH +ST E+E ++AS ++E AVV P E++G
Sbjct: 486 FTYDVAVKDKDGHFWVLGRNDDVINVSGHRLSTMEMESLVASVNGIAECAVVGIPDEIRG 545
Query: 618 EALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILR 677
FV LK + + +T++ ++ + IG FAAP + +PKT SGKI+RR LR
Sbjct: 546 LTPVVFVSLKNDIS-ATGIEETISKMIEEGIGKFAAPSDVIVVEEMPKTPSGKILRRFLR 604
Query: 678 KIAVGDHEVGDISTLADPGVVEEL 701
+I V VGD + L +P +E+L
Sbjct: 605 EIYVYGDIVGDRTGLENPASIEKL 628
>UniRef50_P28812 Cluster: Uncharacterized protein PA3568; n=81;
cellular organisms|Rep: Uncharacterized protein PA3568 -
Pseudomonas aeruginosa
Length = 628
Score = 245 bits (600), Expect = 3e-63
Identities = 156/473 (32%), Positives = 235/473 (49%), Gaps = 34/473 (7%)
Query: 24 YKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRVFVKFMEEAELNVCY 83
Y + + RS+ E FW E A+ W+ AP ++ D T ++ + LN Y
Sbjct: 3 YLQQHARSIAEPAAFWAEQARSLAWYQAP--ANILESLPDGTH-----RWFADGRLNSAY 55
Query: 84 NLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAVY 143
LDR ++ G G++ A ++ R +Y +L D V + A L A G+ KGDRV +Y
Sbjct: 56 LALDRQIEEGRGEQTALIYDSPVTGTQDRYSYLRLRDEVARLAGALRALGVGKGDRVIIY 115
Query: 144 MPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGERMYVY 203
MPM+ +A + MLACAR+GAVH+VVF GF+ LA R+ DA KL++TA +R+ Y
Sbjct: 116 MPMVPQAAMAMLACARLGAVHSVVFGGFAPYELALRIDDATPKLVLTASCGLEFDRVIEY 175
Query: 204 KRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIWWHEVLE 263
K D A+E A H V + R+ PG D+ W + L
Sbjct: 176 KPLVDKALELAIHQPAH-VMVWQRPQAPARLHPG----------------RDLDWQDCLA 218
Query: 264 GESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYW 323
+ P VA+ DPL+++YTSG+TGKPKG+V G+ + R ++ DV+W
Sbjct: 219 A-AEPADPLPVASGDPLYIMYTSGTTGKPKGIVRDNGGHAVAVRYAVRTIYGMQAGDVWW 277
Query: 324 CTADVGWITGHTYVVYAPLANAATSVMFEGTPY-FPKVDRYWSIINKYKVTQFYTAPTAI 382
+DVGW+ GH+ +VY PL T+V +EG P P YW +I +++V + APTAI
Sbjct: 278 GISDVGWVVGHSLIVYGPLMCGCTTVFYEGKPVRTPDAGAYWRVIEEHRVNSLFCAPTAI 337
Query: 383 RALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTET 442
RA+ + + DL SLR L GE ++ + W G+ + D +WQTET
Sbjct: 338 RAIRKE-DPHGERVKRYDLGSLRHLFLAGEKLDSSTQHWLEEHTGR---PVHDHWWQTET 393
Query: 443 GGHVITGLPGAT--PMKPGAAEKKHPVYYSSM--DTFRPKQGWDRTVMIVHLP 491
G V G ++ G+ + P Y+ + D RP + +++ LP
Sbjct: 394 GWPVTAPCIGIAGHDLRAGSTNRAVPGYHVQVLDDEGRPLGANRQGAIVIALP 446
Score = 148 bits (359), Expect = 4e-34
Identities = 83/200 (41%), Positives = 120/200 (60%), Gaps = 3/200 (1%)
Query: 504 GVEPKILNEDGVEIEGPGEGYLVFARPWP-GMMRTLLEDQDRFERVYFSKFPGYYCTGDG 562
G ++L+++G + +G +V A P P G +TL D R+ + Y +PGYY TGDG
Sbjct: 420 GYHVQVLDDEGRPLGANRQGAIVIALPLPPGCAQTLWGDHPRYLQAYLGNYPGYYHTGDG 479
Query: 563 VRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALYC 622
DEDG+++I GR DD++NVSGH +ST E+E +A V+E AV+ E+KG
Sbjct: 480 GYLDEDGFVYIMGRTDDVINVSGHRLSTGEMEERVAQHQAVAECAVIGVRDELKGHVPLG 539
Query: 623 FVVLKEGLQFDAD-LVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKIAV 681
VVLK+ A+ L + L LVR++IGA A + LPKTRSGKI+R +LRKIA
Sbjct: 540 LVVLKDDAGIAAEQLQRELVALVREQIGALACFQRVVVVKRLPKTRSGKILRAVLRKIAD 599
Query: 682 GDHEVGDISTLADPGVVEEL 701
G+ + ST+ DP ++ E+
Sbjct: 600 GE-DYAAPSTIDDPTILGEI 618
>UniRef50_Q9RX55 Cluster: Acetyl-CoA synthase; n=4; cellular
organisms|Rep: Acetyl-CoA synthase - Deinococcus
radiodurans
Length = 642
Score = 244 bits (598), Expect = 5e-63
Identities = 160/472 (33%), Positives = 251/472 (53%), Gaps = 40/472 (8%)
Query: 1 MSSRMYKPTDHVIKKSYLPSIQKYKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKY 60
+++ + PTD +KK+ + ++ +++ R + + +W VA E W V P
Sbjct: 6 LTTPLVSPTD-ALKKTAPVTPERAQQL--RDMPAGD-YWLSVASELTWDVPPTTA----- 56
Query: 61 NFDITKGRVFVKFMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLD 120
+ T G ++ A+ NV N LDR+ KN ++A ++E T +Y L D
Sbjct: 57 -LEGTFGDF--QYFPGAKGNVSVNCLDRHPKN----RVALYYEREDGLKETW-SYGDLTD 108
Query: 121 LVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERL 180
+FA L G+ KGDRVA+Y+ + EA I + AC RIGA+++V+FAGFS+ A+ +RL
Sbjct: 109 ATARFAAALQDLGVDKGDRVAIYLSNVPEAFIAIHACYRIGAIYSVIFAGFSASAVRDRL 168
Query: 181 SDAKAKLLVTADGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSL 240
+DA+ K++V DG R R K T D+A+E K V +V LD P G
Sbjct: 169 TDAQPKVVVCTDGTLRRGRNIPLKATLDEALEGLE---KPTV---IVARRLDPFLPLG-- 220
Query: 241 KSEIKDLYNWNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTA 300
E ++ + E+LE + P + A DP F++YTSG+T KPKG+VH+
Sbjct: 221 ------------ENELDFAELLEKTTRRAAPVSLDANDPGFIIYTSGTTSKPKGLVHSGI 268
Query: 301 GYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKV 360
G+L A ++ + DVYWCTADVGW+T + + LA+ AT V++EG+ P
Sbjct: 269 GFLTGTYANVKWALNLQPDDVYWCTADVGWLTFPIFALVGGLAHGATHVIYEGSIDTPTP 328
Query: 361 DRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWL 420
+R + II +Y+ + +TAPTA+R L D L DLS L+++ VGEP++P W
Sbjct: 329 ERPYQIIERYRADKVFTAPTALRMLR---RSGDEALARYDLSPLQLVALVGEPLDPETWH 385
Query: 421 WYYTRIGKERCSIVDTFWQTETGGHVITGLPGATPMKPGAAEKKHPVYYSSM 472
W + +G R + +T+ QTETG + + G T +PG+ P Y +++
Sbjct: 386 WTHDVLGGGRLFVNNTYGQTETGTAWASSMVGLTEGRPGSCGHPLPGYRAAV 437
Score = 167 bits (406), Expect = 9e-40
Identities = 85/205 (41%), Positives = 118/205 (57%), Gaps = 5/205 (2%)
Query: 499 GFPFFGVEPKILNEDGVEIEGPGE-GYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYY 557
G P G +++EDG GP E G L P+P + RT+ D DR+ Y S+FPG Y
Sbjct: 427 GHPLPGYRAAVVHEDGTPC-GPNELGSLTLTEPFPCLARTVWGDHDRYVETYLSEFPGKY 485
Query: 558 CTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKG 617
D D DG LW+TGR+DD++NV+GH + T E+E L + P VSEAAVV P ++KG
Sbjct: 486 AAADAALLDSDGQLWVTGRLDDVMNVAGHRLGTMEMEAALLTHPAVSEAAVVAMPDDIKG 545
Query: 618 EALYCFVVLKEGLQFDADLV---KTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRR 674
FVV + G++ D DL L V +GA A P + P +P+TRSGKIMRR
Sbjct: 546 AVPVAFVVPRAGIRLDTDLTWLENELADAVVSGVGAIARPGRVVVTPTVPRTRSGKIMRR 605
Query: 675 ILRKIAVGDHEVGDISTLADPGVVE 699
+LR + + GD+++L +P +E
Sbjct: 606 LLRDLLLTGEVKGDLTSLENPDALE 630
>UniRef50_A7DME3 Cluster: AMP-dependent synthetase and ligase; n=1;
Candidatus Nitrosopumilus maritimus SCM1|Rep:
AMP-dependent synthetase and ligase - Candidatus
Nitrosopumilus maritimus SCM1
Length = 641
Score = 244 bits (598), Expect = 5e-63
Identities = 161/465 (34%), Positives = 260/465 (55%), Gaps = 37/465 (7%)
Query: 1 MSSRMYKPTDHVIKKSYL-PSIQKY-----KEMYERSLTESELFWTEVAQEFQWHVAPKP 54
MS + PT + +++S + +QK+ E+ ++S E E FW EV ++ V P
Sbjct: 1 MSDFEFVPTQNQVEESNIFRFMQKHGLSSLSELSKKSKDELEWFWQEVDKDIGV-VWDSP 59
Query: 55 GGFMKYNFDITKGRVFVKFMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYT-RI 113
+ D + G K+ + N+ + +++ VK DK A+ + S D T ++
Sbjct: 60 YSQI---LDSSNGIAHSKWFVNGKTNIYKSTVEKFVKLT-PDKTAYHFV--SEDGATSKL 113
Query: 114 TYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSS 173
TY++L + V + ANGL + ++KGD VA+Y+PMI EA++ +LA A+IGAV TV+F+G+S+
Sbjct: 114 TYQELDNKVSKLANGLKSLRVKKGDVVAIYLPMIQEAILAILASAKIGAVQTVIFSGYST 173
Query: 174 DALAERLSDAKAKLLVTADGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDR 233
++L RL D AK+L +DG R + K T AI+ T+ V+ +VV
Sbjct: 174 ESLHIRLQDCNAKVLFVSDGFCRKGKPISQKETVQKAIQD--TY----VEKTIVV----- 222
Query: 234 VTPGGSLKSEIKDLYNWNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPK 293
K + D Y N E ++++E++E ++ CP E + +EDPLF+LYTSG+TGKPK
Sbjct: 223 -------KYKGVDKYE-NSENIVFYNELIESQNPDCPTEIMDSEDPLFILYTSGTTGKPK 274
Query: 294 GVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEG 353
GVVH G+ ++A Y+ D +DV + AD+GWITG + VY L A+SV+++G
Sbjct: 275 GVVHVHGGFSVFAGHQAAYLIDLQAQDVLFWPADIGWITGLVWNVYGLLIMGASSVIYDG 334
Query: 354 TPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEP 413
FPK DR W I+++Y T F +PTA R L N E L L ++ + + GEP
Sbjct: 335 ALDFPKSDRVWKILSEYNATIFGISPTATR-LFKKNNEEP--LQNFSLDKIKNIPTTGEP 391
Query: 414 INPAAWLWYYTRIGKERCSIVDTFWQTETGGHVITGLPGATPMKP 458
++ +W W + ++G ++ I++ TE GG +++ PG +KP
Sbjct: 392 LDEDSWWWLFDKVGNKKIPIMNLSGGTEIGGAMLSVFPG-MKLKP 435
Score = 160 bits (389), Expect = 1e-37
Identities = 82/205 (40%), Positives = 127/205 (61%), Gaps = 4/205 (1%)
Query: 497 TRGFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGY 556
T G P G+ +++ DG ++ GYL+ PWPGM R LL D +RF Y+S+F
Sbjct: 437 TVGIPVPGMNLDVVDNDGNSVKNKN-GYLIIRSPWPGMTRGLLNDNERFIETYWSRFKDI 495
Query: 557 YCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVK 616
+ GD V D+DG ++ GR DD++NVSGH MSTAE+E ++ S ++S+AA + P ++
Sbjct: 496 WFHGDYVFVDQDGLWYMRGRTDDVINVSGHRMSTAEIEHMVISHEKISDAASIAIPDDIT 555
Query: 617 GEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRIL 676
GEA+ F V + D++L ++ + QKIG A P + LPKTR+GKIMRR+L
Sbjct: 556 GEAIVIFFVADS--KDDSNLEGIVSDFISQKIGKVAKPKFVYQLTDLPKTRTGKIMRRLL 613
Query: 677 RKIAVGDHEVGDISTLADPGVVEEL 701
+ +G E+GD+S+L +P +++E+
Sbjct: 614 KSKLLG-KELGDLSSLENPQILDEV 637
>UniRef50_A0JS90 Cluster: AMP-dependent synthetase and ligase; n=16;
Bacteria|Rep: AMP-dependent synthetase and ligase -
Arthrobacter sp. (strain FB24)
Length = 607
Score = 241 bits (590), Expect = 5e-62
Identities = 156/421 (37%), Positives = 216/421 (51%), Gaps = 42/421 (9%)
Query: 276 AEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHT 335
AE+ + +TSG+TG PKG +H + A F + D H DVYWCTAD GW+TG +
Sbjct: 219 AEEMALLHFTSGTTGTPKGAIHVHDAVTAHHATGF-FALDLHADDVYWCTADPGWVTGTS 277
Query: 336 YVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGN 395
Y V APL + T+++ E +R++ I+ + VT +YTAPTA+R LM G+
Sbjct: 278 YGVIAPLTHGVTTIVDEEE---MDAERWYRILAEQHVTVWYTAPTALRMLM---KAGAGH 331
Query: 396 LTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTETGGHVITGLPGATP 455
DLS+LR + SVGEP+NP +W G+ + D +WQTETGG +I+ P A
Sbjct: 332 AAGHDLSALRFVASVGEPLNPEVVVWGQEAFGQ---PVHDNWWQTETGGIMISNYP-AME 387
Query: 456 MKPGAAEKKHPVYYSSMDTFRPKQGWDRTVMIVHLPNKSNRTRGFPFFGVEPKILNEDGV 515
++PG SM RP G + ++ K+ ILN + V
Sbjct: 388 IRPG-----------SMG--RPLPGVEAAIVARDPDGKA-------------VILNGEAV 421
Query: 516 EIEGP-GEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYCTGDGVRRDEDGYLWIT 574
+ P G G L WP M R L + +R+ R + G+Y TGD R D DGY W
Sbjct: 422 LVTEPEGVGELALRPGWPSMFRGYLHEDERYLRCFAG---GWYLTGDLARMDADGYFWFV 478
Query: 575 GRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALYCFVVLKEGLQFDA 634
GR DD++ SGHL+ EVE L V+EA V+ P V GE + FV L+ G Q
Sbjct: 479 GRGDDVIKSSGHLIGPFEVESSLMEHEAVAEAGVIGVPDPVAGEVVKAFVELRTGWQPSE 538
Query: 635 DLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKIAVGDHEVGDISTLAD 694
L + R+++G AP + LPKTRSGKI+RR+L+ +G E GD ST+
Sbjct: 539 SLKLDIIGFARKRLGPAVAPRLLDFTDALPKTRSGKILRRLLKARELGLPE-GDTSTIES 597
Query: 695 P 695
P
Sbjct: 598 P 598
Score = 38.7 bits (86), Expect = 0.54
Identities = 28/123 (22%), Positives = 53/123 (43%), Gaps = 1/123 (0%)
Query: 74 MEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKG 133
+ + +N+ Y +DR+ A + S ++Y +L + +FA L G
Sbjct: 49 LPDGGVNIAYEAVDRHAAGERAGHEALRFI-RSDGTARSLSYAELAEQTGRFAGVLHRLG 107
Query: 134 IRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADG 193
I +G+RV M E + +L + +V +F+ F + + +RL + LVT
Sbjct: 108 IGRGERVFSLMGRSPELYVAVLGTLKNASVFCPLFSAFGPEPVRQRLHLGSGRALVTTRA 167
Query: 194 AWR 196
+R
Sbjct: 168 LYR 170
>UniRef50_Q22UI3 Cluster: AMP-binding enzyme family protein; n=6;
Oligohymenophorea|Rep: AMP-binding enzyme family protein
- Tetrahymena thermophila SB210
Length = 670
Score = 238 bits (582), Expect = 4e-61
Identities = 149/448 (33%), Positives = 231/448 (51%), Gaps = 32/448 (7%)
Query: 24 YKEMYERSLTE--SELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRVFVKFMEEAELNV 81
Y+ +ERS+ E +W E W P + + G F ++ +++++N+
Sbjct: 35 YQIAFERSVNPLTREDYWREQTHFVDWFKRPD---VILDKSNPNPG--FWRWFKDSQVNM 89
Query: 82 CYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVA 141
CYN +DR+VK DK A W T+ +L D V + A G++KGDRV
Sbjct: 90 CYNAVDRHVKQ-LHDKPALHWISPYEKIERTYTWAELQDNVARLAGVYQNLGVKKGDRVV 148
Query: 142 VYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGERMY 201
+YMPM+ EAV MLACAR+GA+H+VVF GF++ LA R+ D++ L++ + ++
Sbjct: 149 IYMPMVPEAVFGMLACARLGAIHSVVFGGFAAKELASRIKDSEPALILGGSFGYEPGKVI 208
Query: 202 VYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIWWHEV 261
YK+ D+AI+ A + + + PG + K+L + ++ D
Sbjct: 209 NYKKILDEAIDIAGAQNTKVLVYQRDEKNKCSMVPGRDY--DYKELISRAQKAD------ 260
Query: 262 LEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDV 321
C P V + PL++LYTSG+TG+PKG+V TAG + A +++ D H+ DV
Sbjct: 261 -------CVP--VEGDHPLYILYTSGTTGQPKGIVRDTAGTCVAAQWAMKHIVDIHKGDV 311
Query: 322 YWCTADVGWITGHTYVVYAPLANAATSVMFEGTPY-FPKVDRYWSIINKYKVTQFYTAPT 380
Y+ +D+GW+ GH ++VY PL AT+++ EG P P +YW II KY+V YTAPT
Sbjct: 312 YFSGSDIGWVVGHQFIVYGPLLRGATTILHEGKPTGTPDASQYWRIIEKYRVKGLYTAPT 371
Query: 381 AIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQT 440
A+RA+ ++ + DLSSL + GE + + W + + I D +WQT
Sbjct: 372 AMRAIRKE-DLNGDWIKKFDLSSLTNVALAGERCDVPTYEWIHKHVPG---LINDNYWQT 427
Query: 441 ETGGHVITGLPG--ATPMKPGAAEKKHP 466
ETG + P+KPG A K P
Sbjct: 428 ETGWVISGNFQNLHTFPIKPGTACKPVP 455
Score = 124 bits (300), Expect = 6e-27
Identities = 77/204 (37%), Positives = 106/204 (51%), Gaps = 3/204 (1%)
Query: 501 PFFGVEPKILNEDGVEIEGPGE-GYLVFARPWP-GMMRTLLEDQDRFERVYFSKFPGYYC 558
P G + IL+E EI+ P + G + P P M TL + FE+ Y PGYY
Sbjct: 453 PVPGFDVHILDEHNQEIKNPNKLGRICIKLPMPPSFMLTLYNNDSVFEQKYLHDSPGYYL 512
Query: 559 TGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGE 618
GD DEDGYL + RIDD++N +GH +ST +E L + EAAVV K + KGE
Sbjct: 513 AGDSGYFDEDGYLNVMARIDDVINTAGHRLSTGSMEEALLKHDNIVEAAVVAKHCDFKGE 572
Query: 619 ALYCFVVLKEGLQFDADLV-KTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILR 677
+ FVV K+ + D + K L+R++IG A+ LPKTRSGKI+R L+
Sbjct: 573 VPFGFVVPKDSQRVDIQVFEKECVSLIRKEIGPVASFKNCIVVEKLPKTRSGKILRNTLK 632
Query: 678 KIAVGDHEVGDISTLADPGVVEEL 701
KI G T+ D V+ ++
Sbjct: 633 KIVDGKQIDRIPPTIEDDTVIPKI 656
>UniRef50_A2TC85 Cluster: AMP-dependent synthetase and ligase; n=4;
Bacteria|Rep: AMP-dependent synthetase and ligase -
Sphingomonas yanoikuyae
Length = 643
Score = 236 bits (578), Expect = 1e-60
Identities = 152/436 (34%), Positives = 219/436 (50%), Gaps = 37/436 (8%)
Query: 38 FWTEVAQEFQWHVAPKPGGFMKYNFDITKGRVFVKFMEEAELNVCYNLLDRNVKNGFGDK 97
FW E A+ W P D + G + E LN C+N LDR+V+ G GD
Sbjct: 24 FWLEAAKAIDWVENPPRA------HDQSMG-----WFPEGILNTCHNCLDRHVQAGRGDA 72
Query: 98 IAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLAC 157
+A ++ TYR+LL + A L + G +KGDRV +YMPMI E V MLAC
Sbjct: 73 LALAYDSPVTGTIRHYTYRELLHETERTAAMLASLGAKKGDRVILYMPMIPETVFAMLAC 132
Query: 158 ARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGERMYVYKRTCDDAIEKARTF 217
AR+G +H+VVF GF+ LA+R+ DA KL++TA G R YK D+A+ A
Sbjct: 133 ARLGVIHSVVFGGFAPPELAKRIDDATPKLVLTASCGIEGSRTIAYKPLVDEALVLAA-- 190
Query: 218 FKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIWWHEVLEGESNICPPEWV--A 275
H V+ ++V L +++ + DI WH++ +++ P V A
Sbjct: 191 --HSVEHVVLVQR-------EQLTADLMPV------RDIDWHDLRRRTADMPVPPCVPLA 235
Query: 276 AEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHT 335
+ DPL++LYTSG+TG PKGVV G+ + + + ++ D +W +DVGW+ GH+
Sbjct: 236 SGDPLYILYTSGTTGTPKGVVRDNGGHAVALSWSMANIYGIGAGDTFWAASDVGWVVGHS 295
Query: 336 YVVYAPLANAATSVMFEGTPY-FPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDG 394
Y+VYAPL AT+V+FEG P P +W I ++ V F+TAPTAIRA+ + +
Sbjct: 296 YIVYAPLLVGATTVLFEGKPVGTPDPGTFWRTIARHNVKSFFTAPTAIRAIRKE-DPDAR 354
Query: 395 NLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTETGGHVITG--LPG 452
L + R + GE +P W G ++D +WQTE G I G
Sbjct: 355 FLKEIGTGACRAVFLAGERADPETIAWLERLSG---LPVIDHWWQTELGWPAIASCFAMG 411
Query: 453 ATPMKPGAAEKKHPVY 468
KPG+A P Y
Sbjct: 412 DLRRKPGSAGFPVPGY 427
Score = 138 bits (334), Expect = 5e-31
Identities = 80/199 (40%), Positives = 114/199 (57%), Gaps = 5/199 (2%)
Query: 499 GFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWP-GMMRTLLEDQDRFERVYFSKFPGYY 557
GFP G + IL++DG+ + G +V P P G R+L + F R F FPGYY
Sbjct: 421 GFPVPGYQFAILDDDGLALPDGASGNVVIETPLPPGTFRSLWNNNATFVR-NFETFPGYY 479
Query: 558 CTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKG 617
TGD RD +G++ I GR DD++N++GH +ST ++E +++ P V+E AVV +KG
Sbjct: 480 ETGDAGFRDSEGFMHIMGRTDDIINIAGHRLSTGQMEEIVSRQPGVAECAVVGADDNLKG 539
Query: 618 EALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILR 677
FV + G D LV+ L VR ++GA AA + LPKTRSGKI+R +LR
Sbjct: 540 MVPIAFVTPQAGYATDKSLVERSVLSVRSELGAIAALKAVLVVEQLPKTRSGKILRSLLR 599
Query: 678 KIAVGDHEVGDI-STLADP 695
KI + E DI +T+ +P
Sbjct: 600 KIV--NREPFDIPATIDEP 616
>UniRef50_Q8ZV36 Cluster: Acetyl-coenzyme A synthetase; n=4;
Pyrobaculum|Rep: Acetyl-coenzyme A synthetase -
Pyrobaculum aerophilum
Length = 615
Score = 235 bits (576), Expect = 2e-60
Identities = 147/426 (34%), Positives = 226/426 (53%), Gaps = 46/426 (10%)
Query: 24 YKEMYERSLTESELFWTEVAQEFQWHVA-PKPGGFMKYNFDITKGRVFVKFMEEAELNVC 82
Y E + +S++ E+FW VA+E W KP D F ++ N+
Sbjct: 3 YIEFWRKSISYPEIFWESVAKELFWKKKWEKP-------LD-GSNPPFYRWFVGGVTNIT 54
Query: 83 YNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAV 142
YN+L+R+ K DK A W + + ITY +L V ++A L G+++GDRV +
Sbjct: 55 YNILERHSK----DKPAIIWFNSELKPHI-ITYGELSQEVNKWACLLKKAGVQQGDRVTI 109
Query: 143 YMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGERMYV 202
YMPMI +A MLA A+IGAVH VVF+GFS AL ER+ D+ +K+++T D R ++
Sbjct: 110 YMPMIPQAAYAMLAVAKIGAVHNVVFSGFSVRALHERILDSGSKIILTVDAMRRRGKVIK 169
Query: 203 YKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIWWHEVL 262
A + AR +V N+L G +++E N E+ +I +
Sbjct: 170 LAEIALKAADSARV---------VVFNYLGEKIDGDFVQAE-----NLLEKCEIEY---- 211
Query: 263 EGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVY 322
WV ++DPLF+LYTSG+TGKPKG+ H Y+++A A ++ F + + D+
Sbjct: 212 ---------TWVKSDDPLFILYTSGTTGKPKGIYHGHGSYMVWAYAHTKWFFGFEKGDIL 262
Query: 323 WCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAI 382
+ TAD+GWI GHTY +Y PL N +T V +E P +P +W I+++ K T + +PTA+
Sbjct: 263 FSTADIGWINGHTYGLYGPLLNGSTVVWYEDAPDYPHPGVWWEIVDRSKATFIWLSPTAV 322
Query: 383 RALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKER--CSIVDTFWQT 440
R LM + + L SL+++ S GE + AW W + + K R C +V+T+ QT
Sbjct: 323 RLLMRYGEEWPAKYS---LESLKMVVSAGEILGKEAWKWLKSHVCKNRQGCHVVETWGQT 379
Query: 441 ETGGHV 446
E G +
Sbjct: 380 ENSGFI 385
Score = 153 bits (370), Expect = 2e-35
Identities = 80/204 (39%), Positives = 126/204 (61%), Gaps = 5/204 (2%)
Query: 499 GFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRT-LLEDQDRFERVYFSKFPGYY 557
G P+ G++ +I +++G E+ +G++V P P + + R+ Y+SKFPG Y
Sbjct: 404 GLPYPGIDVRIYDDNGQELPPGAKGHVVILPPTPPAFALGIWGNPARWIEAYWSKFPGVY 463
Query: 558 CTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKG 617
TGD +DE+GY++I GR DD++ ++GH +S AEVE ++A+ P V EAA V P E+KG
Sbjct: 464 YTGDVGIKDEEGYIYILGRADDVIKIAGHRLSPAEVENIVATFPGVVEAATVGVPDEIKG 523
Query: 618 EALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILR 677
L FVV KEG++ ++ + + ++++ G A + LPKTR+GKIMRR+LR
Sbjct: 524 TTLAIFVVPKEGVRINS---QEVVEFLKREFGPVAVVSKVYVVNKLPKTRTGKIMRRVLR 580
Query: 678 KIAVGDHEVGDISTLADPGVVEEL 701
+ G E+GDISTL D ++E+
Sbjct: 581 ALISGG-EIGDISTLEDEASIDEV 603
>UniRef50_Q5V498 Cluster: Acyl-coenzyme A synthetases; n=5;
Halobacteriaceae|Rep: Acyl-coenzyme A synthetases -
Haloarcula marismortui (Halobacterium marismortui)
Length = 673
Score = 232 bits (568), Expect = 2e-59
Identities = 145/446 (32%), Positives = 226/446 (50%), Gaps = 23/446 (5%)
Query: 21 IQKYKEMYERSLTESELFWTEVAQEFQWHVAPKPGG---FMKYNF--DITKGRVFVKFME 75
I Y E+ ER+ T+ + E+ W + P+ F Y+ D ++G F +
Sbjct: 33 IDNYDELIERTTTDLPEE-PDSGVEWFWDLLPEYLDIEFFDAYDQVRDNSEGPQFTDWYA 91
Query: 76 EAELNVCYNLLDRNVKNGFGDK--IAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKG 133
+N +N+LDR+ + +A WEG P D ITY +L + AN L + G
Sbjct: 92 GGTINAAHNVLDRHAARDSPTRNTVALIWEGE-PGDVREITYHELNRQASKVANYLESVG 150
Query: 134 IRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADG 193
+ GD V +YMPM+ E + C ++GA+ +F+GF DA A R++DA+ +L T DG
Sbjct: 151 VGTGDTVGLYMPMVPEVASILYGCLKVGAIAVPIFSGFGVDATATRIADAECSVLFTGDG 210
Query: 194 AWRGERMYVYKRTCDDAIEKA-RTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNE 252
+R K + D+AI++A V+ +V + L + + + W
Sbjct: 211 FYRRGSGVHLKESADEAIKQAGEELGTTPVEHTVVYDRL-------GIADDPDETIRWTR 263
Query: 253 ETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRY 312
D WW E + + + + + +LY+SG+TGKPKG+VHT AG LM AA +
Sbjct: 264 R-DEWWDEAIATADDEYAAKELPSNQESMLLYSSGTTGKPKGIVHTHAGALMQAAKEIYF 322
Query: 313 VFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKV 372
FD+ D ++ +D+GW+ G + + A T M+EG P P+ DR+W +I+++ +
Sbjct: 323 GFDHKPSDRFFWVSDIGWMMG-PWTLLGNHAFGGTVFMYEGAPDHPEPDRFWEMIDRHDI 381
Query: 373 TQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCS 432
T F +PTAIRAL D L DLSSLR+LGS GEP +P +W W+Y +G E C
Sbjct: 382 TTFGVSPTAIRALR---KKGDEWLEGHDLSSLRLLGSTGEPWDPESWQWFYEHVGDEDCP 438
Query: 433 IVDTFWQTETGGHVITGLPGATPMKP 458
I++ TE G + +P +KP
Sbjct: 439 IINISGGTEIMGCFLMPMP-TQSLKP 463
Score = 123 bits (297), Expect = 1e-26
Identities = 72/218 (33%), Positives = 120/218 (55%), Gaps = 4/218 (1%)
Query: 487 IVHLPNKSNR--TRGFPFFGVEPKILNEDGVEIEGPGE-GYLVFARPWPGMMRTLLEDQD 543
++ +P +S + T G P G++ I++ DG I E GYLV P M R+L D
Sbjct: 453 LMPMPTQSLKPCTLGGPGLGMDIDIVDSDGESIADTHERGYLVARDSCPSMTRSLWSGDD 512
Query: 544 RFERVYFSKFPGYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRV 603
R+ Y+S + + GD ++DEDG ++ GR DD+LNV+G + AEVEG V
Sbjct: 513 RYLHEYWSTWDDVWDHGDWAQKDEDGLWFLHGRADDVLNVAGRKVGPAEVEGAAMEHDAV 572
Query: 604 SEAAVVPKPHEVKGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGL 663
++AA V P + G A+ + VL+ G + + DL + V +++G P +
Sbjct: 573 NQAAAVGVPDDTTGTAVVLYAVLEPGYESNDDLRDDIRAAVGEELGKPFRPREVLFVDEF 632
Query: 664 PKTRSGKIMRRILRKIAVGDHEVGDISTLADPGVVEEL 701
PKT+SGKI+RR + + G+ ++GD+S++ +P ++E+
Sbjct: 633 PKTQSGKIIRRAIAGVYRGE-DLGDMSSIENPTALDEV 669
>UniRef50_Q81Q80 Cluster: Acetoacetyl-CoA synthase, putative; n=10;
Bacillus|Rep: Acetoacetyl-CoA synthase, putative -
Bacillus anthracis
Length = 646
Score = 231 bits (566), Expect = 4e-59
Identities = 153/430 (35%), Positives = 225/430 (52%), Gaps = 38/430 (8%)
Query: 22 QKYKEMYERSLTESELFWTEVAQE--FQWHVAPKPGGFMKYNFDITKGRVFVKFMEEAEL 79
+ Y+ Y +S+ E+ FW E + +QW KP + D+ G F ++
Sbjct: 28 EDYETFYNKSIEETAWFWGEAEKVVGYQWM---KPYTEV---LDLQNGTPFAQWYNGGTC 81
Query: 80 NVCYNLLDRNVKNG-FGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGD 138
NV ++L R + + + A +EG + + TY +L V + ANGL GI KGD
Sbjct: 82 NVVESVLSRWLADDETRTQPALQYEGENGTSKS-FTYEELDSWVSRAANGLKHAGIEKGD 140
Query: 139 RVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGE 198
RV +YMPMI E V+ MLA +IGA+ + +F+GF+SDA+ R+ A +K+++TADG R
Sbjct: 141 RVTIYMPMIPETVVAMLAVMKIGAIISPIFSGFASDAVMTRVQAAGSKMIITADGFSRRG 200
Query: 199 RMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHL-DRVTPGGSLKSEIKDLYNWNEETDIW 257
++ K D A E T V+ ++V H + TP +N+ D
Sbjct: 201 KIVSLKDEVDKACEHCPT-----VEKVVIVRHAGNDFTP-----------HNY----DFS 240
Query: 258 WHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYH 317
W LE E E + ++DPL ++YTSG+TGKPKG VHT AG+ + AA + +
Sbjct: 241 W-STLEKEKPFVHAEEMHSDDPLMLIYTSGTTGKPKGTVHTHAGFPLKAAFDAGFGMNIK 299
Query: 318 RRD-VYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFY 376
+ D V W T D+GW+ G ++++ L N AT VM+EG P FPK DR W ++KY++T
Sbjct: 300 QGDRVLWVT-DMGWMMG-PFLLFGSLINGATMVMYEGVPDFPKADRLWETVDKYEITHLG 357
Query: 377 TAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDT 436
+PT IRALMA D + L SL V S GEP NP W+W + +GK I +
Sbjct: 358 ISPTLIRALMAK---GDEYVNKHSLKSLEVFASTGEPWNPDPWMWLFETVGKSNVPICNY 414
Query: 437 FWQTETGGHV 446
TE G +
Sbjct: 415 SGGTEISGGI 424
Score = 141 bits (342), Expect = 5e-32
Identities = 76/195 (38%), Positives = 111/195 (56%), Gaps = 3/195 (1%)
Query: 504 GVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYCTGDGV 563
G+ +L++ G I G L +PW GM ++ ED +R+ Y+S+F + GD V
Sbjct: 444 GMAAVVLDDQGNPIRDE-VGELCLEKPWVGMTKSFWEDDERYVNTYWSRFENKWVHGDWV 502
Query: 564 RRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALYCF 623
D + Y+ ITGR DD LN++G + AE E +L V EAA + P +VKGE +CF
Sbjct: 503 VYDGEQYI-ITGRSDDTLNIAGKRIGPAEYESILVKHNDVIEAAAIGVPDDVKGEVCHCF 561
Query: 624 VVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKIAVGD 683
VVL++ + F +L K L LV IG P I LPKTR+ K+MRR+++ +G
Sbjct: 562 VVLRDNVTFTGELKKELMSLVNSHIGKALCPKDIHVVEDLPKTRNSKVMRRVIKAAYLG- 620
Query: 684 HEVGDISTLADPGVV 698
E+GD+S+L +P VV
Sbjct: 621 KELGDLSSLVNPEVV 635
>UniRef50_Q5P1M8 Cluster: Acyl-CoA synthetase; n=2; Azoarcus|Rep:
Acyl-CoA synthetase - Azoarcus sp. (strain EbN1)
(Aromatoleum aromaticum (strain EbN1))
Length = 663
Score = 230 bits (562), Expect = 1e-58
Identities = 151/443 (34%), Positives = 234/443 (52%), Gaps = 27/443 (6%)
Query: 26 EMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRVFVKFMEEAELNVCYNL 85
++ ER+ E E FW +V + A + D+T G ++ K+ L++ NL
Sbjct: 30 DLRERAAREPERFWDQVLEAIGLDWATP----YRQTLDLTDGVMWPKWFVGGRLDLVDNL 85
Query: 86 LDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMP 145
+ ++ + KIA WEG+ + T ++Y L V + A GL A G+ +G+R+A+Y+P
Sbjct: 86 VGKHAR-ATPAKIAVRWEGDGGELRT-LSYAALAGEVERVAAGLRALGVSEGERIALYLP 143
Query: 146 MILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWR-GERMYVYK 204
M+ EAV+ MLA RIGAV F+G+ +D++A+R++D +A++LV A+G +R G+R+ +
Sbjct: 144 MVAEAVVTMLAATRIGAVFIPFFSGYGADSVAQRVADCEARVLVCANGYFRRGKRVPMLA 203
Query: 205 RTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIWWHEVLEG 264
DA AR C + HL V G + D ++ + +
Sbjct: 204 ----DARAAARA--------CPSLRHLVVVDRLGLGQLAANDGAA-ESFAEVDFRALQAA 250
Query: 265 ESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWC 324
+ P A+ L ++YTSG+TGKPKGVVHT AG+ + AA FD D
Sbjct: 251 SPDRGPASAWPADQTLMLIYTSGTTGKPKGVVHTHAGFPVKAAQDLLMAFDLRADDTLMW 310
Query: 325 TADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRA 384
D+GW+ G ++VY L AT V++EGTP +P R W ++ ++ VT F +PT +R
Sbjct: 311 VTDMGWLMG-PWMVYGGLMLGATLVLYEGTPDYPDAGRLWQVVERHGVTHFGLSPTLVRL 369
Query: 385 LMAHYNVEDGNLTMPD-LSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTETG 443
LMA+ D +L P L +LRV GS GE N A WLW + ++G+ R I++ TE G
Sbjct: 370 LMAN----DASLPAPGALDTLRVFGSTGEAWNEAPWLWLFEQVGQSRRPIINYSGGTEIG 425
Query: 444 GHVITGLPGATPMKPGAAEKKHP 466
G ++ PG P KP A + P
Sbjct: 426 GGILACFPG-LPQKPCAFDGPIP 447
Score = 129 bits (311), Expect = 3e-28
Identities = 76/227 (33%), Positives = 117/227 (51%), Gaps = 8/227 (3%)
Query: 490 LPNKSNRTRGFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVY 549
LP K G P G+ ++L+ DG + G G LV +PWPGM D +R+ Y
Sbjct: 435 LPQKPCAFDG-PIPGMAVEVLDSDGRPVRG-SVGELVIRQPWPGMTHGFWRDTERYREAY 492
Query: 550 FSKFPGYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVV 609
+S +P + GD R D DGY ++ GR DD + ++G + A+ E L S P V EA V
Sbjct: 493 WSVWPDVWVHGDWARVDADGYWFVHGRSDDTIKIAGKRVGPADFESALVSHPLVVEAVAV 552
Query: 610 PKPHEVKGEALYCFVVLKEGLQFDADLVKT----LTLLVRQKIGAFAAPDTIQNAPGLPK 665
P E+KGE CFV + + A + L V +++G P + +PK
Sbjct: 553 GVPDELKGETAVCFVTVADNEALAARPWQAWEAELVDHVGRQLGKPLRPAHVHRVEAIPK 612
Query: 666 TRSGKIMRRILRKIAVGDHEVGDISTLADPGVVEELFNNRP-AEAKP 711
TR+GK +RR++R +G +GD+S++ +P ++ + RP A+A P
Sbjct: 613 TRNGKTVRRVMRNAYLGT-ALGDLSSIENPAAIDAVSALRPSAQAVP 658
>UniRef50_Q140P4 Cluster: Putative acetyl-CoA synthetase and ligase;
n=1; Burkholderia xenovorans LB400|Rep: Putative
acetyl-CoA synthetase and ligase - Burkholderia
xenovorans (strain LB400)
Length = 650
Score = 229 bits (560), Expect = 2e-58
Identities = 145/430 (33%), Positives = 236/430 (54%), Gaps = 41/430 (9%)
Query: 36 ELFWTEVAQEFQWH---VAPKPGGFMKYNFDITKGRVFVKFMEEAELNVCYNLLDRNVKN 92
+ +W VA++F+W + + G F ++ K+ LNVC N +DR ++
Sbjct: 44 DAYWEWVAKKFRWMRPWESVRDGNFPEF-----------KYFAGGMLNVCDNCVDRYAED 92
Query: 93 G-FGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAV 151
+ + A WEG P D ++Y +L +FANGL + G+ +GD VA+Y+P +LE+
Sbjct: 93 PHYASRPAITWEGE-PGDCATLSYAQLRTATARFANGLRSLGVGQGDVVAIYLPNMLESF 151
Query: 152 ICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWR-GERMYVYKRTCDDA 210
+ + AC RIGA++TV+FAGFS+DA A RL ++AK+LVTAD ++R G+++ + +
Sbjct: 152 VAIQACNRIGAIYTVLFAGFSADAAALRLQTSRAKVLVTADASYRRGKQVPLLENA---- 207
Query: 211 IEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIWWHEVLEGESNICP 270
KAR R++ +V+ DR +L + + + E++ +S+ CP
Sbjct: 208 -RKARRSAP-RLEHIVVI---DRTGAAPAL-----------HDGETGYKELVAAQSDDCP 251
Query: 271 PEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGW 330
+ A P F+++TSG+ KPKGVVH+ AG+L+ A ++ + DVYWC ADVGW
Sbjct: 252 CVPLEANAPAFLIFTSGTESKPKGVVHSVAGFLLGTWANVQWQVGPAKDDVYWCAADVGW 311
Query: 331 ITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYN 390
+T V LA+ A+ V +EG P DR++ I N++ VT+ APTA+R L A
Sbjct: 312 LTFPIQAVIGGLAHGASLVCYEGALDTPGKDRFYQIANRHHVTKILIAPTALRMLRA--- 368
Query: 391 VEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTETGGHVITGL 450
+ D + LR++ + GEP++P + W +G ++ IV+ + QTETG +
Sbjct: 369 LGDEVAKANRIDGLRLITTQGEPLDPETYHWTSNTLG-DQLPIVNAYGQTETGSTWTYPV 427
Query: 451 PGATPMKPGA 460
G P+K G+
Sbjct: 428 YGVEPLKAGS 437
Score = 134 bits (325), Expect = 6e-30
Identities = 75/213 (35%), Positives = 109/213 (51%), Gaps = 1/213 (0%)
Query: 499 GFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYC 558
G P G ++L EDG +G LV P+P + RT+ +D R+ YF ++PG Y
Sbjct: 439 GTPVPGHAYRVLLEDGSTAPVGTKGALVLTAPFPTLARTVWDDHQRYLNTYFGRYPGVYN 498
Query: 559 TGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGE 618
T D D G LW+ GR DD++NV+ H +ST E+E V+AS P +++AAVV VKG
Sbjct: 499 TSDEAVVDSTGQLWVLGRGDDVINVAAHRLSTMEIESVVASQPGIADAAVVGVSDAVKGT 558
Query: 619 ALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRK 678
FV L G ++ + + IG A + + LPKTR+GK +RR+LR+
Sbjct: 559 VPVAFVTLVAGAPVES-TIGQICAAASDAIGTIARLEQVFVCKALPKTRAGKTVRRLLRE 617
Query: 679 IAVGDHEVGDISTLADPGVVEELFNNRPAEAKP 711
I D++ + D VV L A +P
Sbjct: 618 IVETGEAKSDLTGIEDLEVVGNLIREVAARKRP 650
>UniRef50_Q67QN3 Cluster: Acetyl-coenzyme A synthetase; n=6;
Bacteria|Rep: Acetyl-coenzyme A synthetase -
Symbiobacterium thermophilum
Length = 649
Score = 226 bits (552), Expect = 2e-57
Identities = 138/436 (31%), Positives = 223/436 (51%), Gaps = 36/436 (8%)
Query: 25 KEMYERSLTESELFWTEVAQEF--QWHVAPKPGGFMKYNFDITKGRVFVKFMEEAELNVC 82
+E+ R+ + FW E ++ +W+ P+ D++ G + + A +N+
Sbjct: 31 EELQARAAADPAWFWGEAVKDIGIEWYEPPRQ------ILDLSAGAPWAAWFRGARMNLA 84
Query: 83 YNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAV 142
+ +D++++N ++A +EG T +YR+L + A L A G+ KGDRV +
Sbjct: 85 HEAVDKHLRNR-PHQLAVIYEGEEGTVRTW-SYRQLWAESNRLAGALRALGVAKGDRVGI 142
Query: 143 YMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGERMYV 202
+P+I EAV M+A AR+GA+ T +F+GF+ A A RL+D +AKLL+TADG +R R+
Sbjct: 143 MLPLIPEAVAAMMAVARLGAIFTPIFSGFAPAAAASRLADCEAKLLITADGFYRRGRLVN 202
Query: 203 YKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIWWHEVL 262
K D+A +A + V +VV G ++ W D+W+HE +
Sbjct: 203 LKAVADEAAAQAPS-----VRNVLVVRRT-----GAAV--------GWTPGRDLWYHEQV 244
Query: 263 EGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVY 322
+ + EDP ++YTSG+TG+PKG VH G+ + AA + FD D+
Sbjct: 245 AAQPARFETARMDPEDPCMIIYTSGTTGRPKGAVHVHGGFPLKAAQDMAHCFDVGPGDLV 304
Query: 323 WCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAI 382
D+GW+ G +++Y L AT +++G P P DR W ++ ++ +T +PT I
Sbjct: 305 MWFTDLGWMMG-PWLIYGGLILGATVFLYDGAPDHPAPDRLWDMVERHGITHLGLSPTVI 363
Query: 383 RALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTET 442
RAL + DLSSLRVLG GEP NP + W+ +G RC +++ TE
Sbjct: 364 RALAP---AGTDWVARHDLSSLRVLGGTGEPWNPEPYRWFVEHVGGGRCPMINYSGGTEI 420
Query: 443 GGHVITGLPGATPMKP 458
G G+ G P++P
Sbjct: 421 SG----GILGCVPIRP 432
Score = 154 bits (373), Expect = 9e-36
Identities = 84/207 (40%), Positives = 118/207 (57%), Gaps = 3/207 (1%)
Query: 504 GVEPKILNEDGVEIEGPGE-GYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYCTGDG 562
G+ +L+E G + PG+ G L PWPGM R D DR+ Y+ +F G++ GD
Sbjct: 444 GMAATVLDERG-QPAPPGQVGELALTAPWPGMTRGFWRDPDRYLETYWRRFEGFWVHGDW 502
Query: 563 VRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALYC 622
D +G+ +I GR DD +NV+G + AE E VL SDPRV EAA V PH VKG A C
Sbjct: 503 ASVDAEGFWYIHGRSDDTINVAGKRVGPAEYESVLVSDPRVQEAATVGVPHPVKGTAPVC 562
Query: 623 FVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKIAVG 682
FVVL+ G+ L L V +++G P+ + LPKTR+ KIMRR++R +G
Sbjct: 563 FVVLRPGVTPGPGLADELRERVAREMGRPLVPEAVLFVGSLPKTRNAKIMRRVVRAAYLG 622
Query: 683 DHEVGDISTLADPGVVEELFNNRPAEA 709
+ + GD+S L +P V E+ R A++
Sbjct: 623 E-DPGDLSALENPEAVAEIQRVRAAQS 648
>UniRef50_Q6L1R5 Cluster: Acetyl-coenzyme A synthetase; n=1;
Picrophilus torridus|Rep: Acetyl-coenzyme A synthetase -
Picrophilus torridus
Length = 396
Score = 215 bits (525), Expect = 3e-54
Identities = 125/402 (31%), Positives = 211/402 (52%), Gaps = 34/402 (8%)
Query: 18 LPSIQKYKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRVFVKFMEEA 77
+ S Y + Y++S+ +W VA E W F K++ ++ KF
Sbjct: 29 IKSNDDYYQFYKKSIENIGDYWAGVASELYW--------FKKWDINMHGDFPDFKFFLNG 80
Query: 78 ELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKG 137
NVC+N +DR+ DK A W + ++ YR L+ +FA+ L + GI+KG
Sbjct: 81 YSNVCFNCIDRHALKK-PDKTAIIWLSEDGLEI-KMDYRSLMIYTSKFASYLRSIGIKKG 138
Query: 138 DRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRG 197
D VA++MP +E+ I + AC RIGA++ ++F+GFS+ AL +RL + K+++TAD R
Sbjct: 139 DVVAIFMPNRIESFIAVHACYRIGAIYNIIFSGFSTKALLDRLYETMPKVIITADKTVRR 198
Query: 198 ERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIW 257
++ K D I ++ K ++V +K + N NE +
Sbjct: 199 GKVINIKEKLDSIINNVKSIQK------VIV-----------VKRFVDTSLNKNE---VS 238
Query: 258 WHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYH 317
+ +VL+ +++ P + A +P FV+YTSG+T +PKG+VH+ G+++ A +Y D +
Sbjct: 239 FEDVLKETNDLIDPVHIEANEPGFVIYTSGTTSRPKGIVHSGIGFMVGAYHNVKYALDLN 298
Query: 318 RRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYT 377
+ DVYWCTAD+GW+T + + LA+ AT V +EG FP +D +++ + KYK+ + +
Sbjct: 299 KSDVYWCTADIGWLTFPIFELVGGLAHGATVVAYEGALDFPGIDNFYNTLEKYKINKLFK 358
Query: 378 APTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAW 419
APT +R L + N + L ++ VGEP++ W
Sbjct: 359 APTFLRMLARYGNEAASKYNI----KLDLISLVGEPLDTKTW 396
>UniRef50_Q9YCA8 Cluster: Acetyl-coenzyme A synthetase; n=2;
Archaea|Rep: Acetyl-coenzyme A synthetase - Aeropyrum
pernix
Length = 656
Score = 215 bits (524), Expect = 5e-54
Identities = 144/446 (32%), Positives = 223/446 (50%), Gaps = 39/446 (8%)
Query: 22 QKYKEMYERSLTESELFWTEVAQEF--QWHVAPKPGGFMKYNFDITKGRVFVKFMEEAEL 79
+ Y+E+ RS + + FW + + +W PK D+++G + ++ L
Sbjct: 28 KSYEELVRRSSEDLKWFWGNLPEWLGVEWFREPKAV------VDLSRGVEWAQWYRGGLL 81
Query: 80 NVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAK--GIRKG 137
N YN++DR VK G+G + AF W G + R TY +L D V + A LL++ G+ G
Sbjct: 82 NAAYNVVDRIVKMGYGHREAFTWVGED-GEVRRYTYLQLKDEVDRMAK-LLSQDYGLGVG 139
Query: 138 DRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRG 197
D VA+Y PM+ E++ MLA ++GAV + +F+GF+ A+AERL +A++LVT DG R
Sbjct: 140 DVVAIYAPMMPESIAAMLAAMKVGAVASPIFSGFAPPAVAERLKLGEARVLVTVDGYLRR 199
Query: 198 ERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIW 257
R K D A++ A +H + VV L P W E D W
Sbjct: 200 GRRIALKEQADQAVKLAGGAVEHVI----VVRRLGIDVP-------------WVEGRDEW 242
Query: 258 WHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYH 317
+ + G++ PE + E P +L+TSG+TG+PKG V + AG ++ + D H
Sbjct: 243 YDRAIAGKAGSAEPEELDPEHPALLLFTSGTTGRPKGAVISHAGAILQPGKEHYFNLDIH 302
Query: 318 -----RRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKV 372
D W D+GW+ G V+ + L A+ +M EG +P R W +I +++V
Sbjct: 303 PAWRGGEDRLWWITDIGWMMGPWQVLGSQLL-GASHLMAEGAIDYPYKSRVWRLIQEHRV 361
Query: 373 TQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCS 432
T F A T R L A V + DLSS+R G+ GEPI+ A W+W ++G R
Sbjct: 362 THFGFAATVARMLRA---VASDTVEDYDLSSIRAFGNTGEPIDHATWMWVMEKLGGWRRP 418
Query: 433 IVDTFWQTETGGHVITGLPGATPMKP 458
+++ TE G ++ P P+KP
Sbjct: 419 LINLSGGTEVFGCILLPSP-VVPLKP 443
Score = 152 bits (369), Expect = 3e-35
Identities = 83/202 (41%), Positives = 122/202 (60%), Gaps = 5/202 (2%)
Query: 501 PFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYCTG 560
P GV+ + +++G + G GYLV +P+P M R L +D +R+ + Y+S+FPG + G
Sbjct: 449 PALGVDADVFDDEGRPVRGE-PGYLVVKKPFPSMTRGLWKDPERYIKTYWSRFPGVWYHG 507
Query: 561 DGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEAL 620
D DEDG+ +I GR DD++ V+G + +AE+E VL P V+EAA + PH +KGE +
Sbjct: 508 DYALVDEDGFWYILGRADDVIKVAGKRIGSAELESVLTQLPEVAEAACIGVPHPIKGEVI 567
Query: 621 YCFVVLKEGLQFDA-DLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKI 679
CF+V K G +DA +L V + G AP+ + LPKTRSGKI RR+LR +
Sbjct: 568 ACFLVPKGG--YDAEELASKARKAVVDRFGKPFAPEHVVIVSELPKTRSGKITRRVLRDL 625
Query: 680 AVGDHEVGDISTLADPGVVEEL 701
A G E ++S L +P VE+L
Sbjct: 626 ARG-VEPKELSVLENPEAVEKL 646
>UniRef50_Q3E187 Cluster: AMP-dependent synthetase and
ligase:Enoyl-CoA hydratase/isomerase; n=2; Chloroflexus
aurantiacus|Rep: AMP-dependent synthetase and
ligase:Enoyl-CoA hydratase/isomerase - Chloroflexus
aurantiacus J-10-fl
Length = 1822
Score = 213 bits (521), Expect = 1e-53
Identities = 149/444 (33%), Positives = 213/444 (47%), Gaps = 27/444 (6%)
Query: 270 PPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVG 329
P E V AE P+F++YTSGSTGKPKGV+H GY+ T R FD D + AD G
Sbjct: 407 PCEPVDAEYPMFIIYTSGSTGKPKGVIHVHGGYVAGVVHTLRVSFDAEPGDTIYVIADPG 466
Query: 330 WITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAH- 388
WITG +Y++ A +A T V+ EG+P FP RY SII +Y V F T ++ +M++
Sbjct: 467 WITGQSYMLTATMAGRLTGVIAEGSPLFPSAGRYASIIERYGVQIFKAGVTFLKTVMSNP 526
Query: 389 YNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTETGGHVIT 448
NVED + + D+ SLRV EP++PA + + + ++++W TE GG V T
Sbjct: 527 QNVED--VRLYDMHSLRVATFCAEPVSPAVQQFGMQIMTPQ---YINSYWATEHGGIVWT 581
Query: 449 GLPGAT--PMKPGAAEKKHPVYYSSMDTFRPKQGWDRTVMIVHLPNKSNRTRGFPFFGVE 506
G P++P A P + + + K P+
Sbjct: 582 HFYGNQDFPLRPDAHTYPLPWVMGDVWVAETDESGTTRYRVADFDEKGEIVITAPY---- 637
Query: 507 PKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPG---YYCTGDGV 563
P + ++ G E YL P +R D +RF + Y+ + P Y GD
Sbjct: 638 PYLTRTLWGDVPG-FEAYLRGEIP----LRAWKGDAERFVKTYWRRGPNGEWGYIQGDFA 692
Query: 564 RRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPR------VSEAAVVPKPHEVKG 617
+ DG + GR DD++NVSGH M T E+EG + D + V VV PH KG
Sbjct: 693 IKYPDGSFTLHGRSDDVINVSGHRMGTEEIEGAILRDRQITPDSPVGNCIVVGAPHREKG 752
Query: 618 EALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILR 677
F+ G + L LVR + GA + P+ P+TRSGK MRR LR
Sbjct: 753 LTPVAFIQPAPGRHLTGADRRRLDELVRTEKGAVSVPEDYIEVSAFPETRSGKYMRRFLR 812
Query: 678 KIAVGDHEVGDISTLADPGVVEEL 701
+ + D +GD +TL +P V+EE+
Sbjct: 813 NMML-DEPLGDTTTLRNPEVLEEI 835
Score = 99.5 bits (237), Expect = 3e-19
Identities = 54/156 (34%), Positives = 92/156 (58%), Gaps = 12/156 (7%)
Query: 70 FVKFMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTR-----------ITYRKL 118
F ++ N C+N +DR+V G+GD++A+++EG+ D+ IT R+L
Sbjct: 100 FYRWFSGGLTNACFNEVDRHVMMGYGDEVAYYFEGDRWDNSLNNGRGGPVVQETITRRRL 159
Query: 119 LDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAE 178
L V + A L G++KGDR+A+ MP I+ + A R+G ++T VF GFS L++
Sbjct: 160 LVEVVKAAQVLRDLGLKKGDRIALNMPNIMPQIYYTEAAKRLGILYTPVFGGFSDKTLSD 219
Query: 179 RLSDAKAKLLVTADGAWRGERMYVYKRT-CDDAIEK 213
R+ +A A++++T+DGA+R ++ YK D A++K
Sbjct: 220 RIHNAGARVVITSDGAYRNAQVVPYKEAYTDQALDK 255
>UniRef50_Q4PHQ0 Cluster: Putative uncharacterized protein; n=1;
Ustilago maydis|Rep: Putative uncharacterized protein -
Ustilago maydis (Smut fungus)
Length = 1162
Score = 213 bits (520), Expect = 1e-53
Identities = 129/365 (35%), Positives = 200/365 (54%), Gaps = 21/365 (5%)
Query: 113 ITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFS 172
+TY +LL V A L KG+ KGD V +YMPM+ E I MLACARIGAVH+VVF GF+
Sbjct: 119 VTYYELLQQVQIVAGILRHKGVSKGDAVVIYMPMVPETSIAMLACARIGAVHSVVFGGFA 178
Query: 173 SDALAERLSDAKAKLLVTADGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNH-L 231
LA+R+ D++ K+++ A + YK D+A++ + K + + + H +
Sbjct: 179 PKELAKRVEDSRCKIIIAASCGLEPKGPVDYKPLVDEALKVSD--HKPQSGLLFLRRHTI 236
Query: 232 DRVTP-----GGSLKSEIKDLYNWNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTS 286
+P GG+ ++W E+ + E + G S VA+EDP++ +YTS
Sbjct: 237 SGHSPAQCANGGANGPAGLPEWDWEVESKLT-SERVGGRSPCWECVPVASEDPIYTIYTS 295
Query: 287 GSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAA 346
G+TG PKGV + G+++ + ++F DV +C +D+GW+ GH+Y+ Y PL A
Sbjct: 296 GTTGAPKGVCRLSGGHIVQLRYSIEHMFGMTPNDVMFCASDLGWVVGHSYIHYGPLLLGA 355
Query: 347 TSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMP--DLSSL 404
TS++FEG P P +W I ++YKVTQ + APTA+RA++ + + + P DL SL
Sbjct: 356 TSIIFEGKPVIPDAGIWWRICSQYKVTQMFCAPTALRAIVGQ-DADATLMRAPGVDLRSL 414
Query: 405 RVLGSVGEPINPAAWLWYYTRIGKERCS----IVDTFWQTETG----GHVITGLPGATPM 456
R L GE P + + R+ KE + D FW +E+G G +++ G P
Sbjct: 415 RALFLAGERSEPQI-VAKFERLLKELAAPGAQTNDNFWSSESGSPITGLMLSSAFGPLPA 473
Query: 457 KPGAA 461
+PG+A
Sbjct: 474 RPGSA 478
Score = 103 bits (248), Expect = 1e-20
Identities = 78/218 (35%), Positives = 114/218 (52%), Gaps = 20/218 (9%)
Query: 499 GFPFFGVEPKILNEDGVEIEGPGEGYLVFARPW-PGMMRTLLEDQDRFERVYFSKFP--- 554
G P G++ +I++++G E+ G LV A P P + L + DRF + YFS F
Sbjct: 479 GLPMPGMDVRIVDDNGRELPRGQMGNLVLAPPLAPSFLGGLWRNPDRFFKSYFSTFASKG 538
Query: 555 GYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHE 614
G++ TGD D+ GY+ I R DD++NVS H + T +E V+ S P V E AVV P +
Sbjct: 539 GWFETGDQGIIDDHGYVSILARSDDIINVSAHRLGTGLIEQVVTSHPDVIECAVVGAPDK 598
Query: 615 VKGEALYCFVVL------------KEGLQFDA--DLVKTLTLLVRQKIGAFAAPDTIQNA 660
+KG++ + VV Q D+ ++K + VR+++G A + A
Sbjct: 599 LKGQSPFAIVVAHSRVAAAAGGESHNSAQSDSAKQMLKNINDHVRKEMGPIAQLSGLIEA 658
Query: 661 PGLPKTRSGKIMRRILRKIAVGDHEVGDISTL-ADPGV 697
LPKTRSGK +RR LR+ AV + G S ADP V
Sbjct: 659 QKLPKTRSGKTLRRSLRQ-AVENAAAGKRSLANADPHV 695
>UniRef50_Q4WAZ5 Cluster: Acetate-CoA ligase, putative; n=1;
Aspergillus fumigatus|Rep: Acetate-CoA ligase, putative
- Aspergillus fumigatus (Sartorya fumigata)
Length = 721
Score = 211 bits (516), Expect = 4e-53
Identities = 138/449 (30%), Positives = 232/449 (51%), Gaps = 41/449 (9%)
Query: 269 CPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHR-RDVYWCTAD 327
C P V ++ P+++++TSG+TG PKGV+ ++ G+ + T +Y+F+ H RDV + +D
Sbjct: 266 CVP--VPSDQPIYIMHTSGTTGAPKGVLRSSGGHAVGLQFTIQYIFNIHGPRDVMFAASD 323
Query: 328 VGWITGHTYVVYAPLANAATSVMFEGTPY-FPKVDRYWSIINKYKVTQFYTAPTAIRALM 386
+GW+ GH+Y++YAPL A +V++EG P P +W ++ +Y+V + PTA+RA+
Sbjct: 324 IGWVVGHSYILYAPLLAGAATVLYEGKPVGTPDASAFWKVVEEYQVNTMFATPTALRAIK 383
Query: 387 AH--YNVEDGNL-TMPDLSSLRVLGSVGEPINPAAWLWYYTRI---GKERCSIVDTFWQT 440
N + + L SL+ L GE P Y + G ++D +W T
Sbjct: 384 QEDPSNTKLAEIGARGGLRSLQALFLAGERSEPTLVSMYQELLDQHGGRNAQVIDNWWST 443
Query: 441 ETGGHVITGLPGATPMKPGAAEKKHPVYYSSMDTFRPKQGWDRTVMIVHLPNKSNRTRGF 500
E G ITG M P ++ T + +D + +P + G
Sbjct: 444 EAGS-PITG----RAMAP---------HFGL--TTELSRSFD-----IPIPPIKPGSAGK 482
Query: 501 PFFGVEPKILNEDGVEIEGPGEGYLVFARP-WPGMMRTLLEDQDRFERVYFSKFPGYYC- 558
P G + ++++E G E+ G +V A P P TL +++RF + Y +F +
Sbjct: 483 PMPGFDVRVVDEHGEEVPKGSMGNIVLALPLGPTAFNTLWLEEERFYKSYLQRFDSRFLD 542
Query: 559 TGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGE 618
TGD D DGY+ + R DD+LNVS + +S+ +E ++S P+V+EA VV P ++KG+
Sbjct: 543 TGDAGWVDPDGYVHVMSRNDDVLNVSAYRLSSGAIEEAISSHPQVAEACVVAIPDQLKGQ 602
Query: 619 ALYCFVVLKEGLQFDA-----DLVKTLTLLVRQKIGAFAAPDTIQNAPG-LPKTRSGKIM 672
+ F+ L D+ + + LVR ++GAFA+ I G +PKTRSGK +
Sbjct: 603 LPFAFISLSVADHPDSAIPAPTIAAEVQSLVRSRVGAFASLGGIVQGKGMIPKTRSGKTL 662
Query: 673 RRILRKIAVGDHEVGDISTLAD-PGVVEE 700
RR+LR++ + + GD+ + P +E+
Sbjct: 663 RRVLREL-LENGVYGDLDRSVEVPSTIED 690
Score = 109 bits (262), Expect = 3e-22
Identities = 72/192 (37%), Positives = 106/192 (55%), Gaps = 8/192 (4%)
Query: 26 EMYERSLTESELFWTEVAQEFQWHVAPKPG--GFMKYNFDITKGRVFVKFMEEAELNVCY 83
E+ +SL + FW+ A+ WH P K D T ++ ++ E++ CY
Sbjct: 9 EVLRQSLQNPDEFWSRQAERLHWHRKPDTALRTTQKSLPDGTAHPMW-EWFPGGEISTCY 67
Query: 84 NLLDRNVKNGFGDKIAFFWEGNSPDDYTR--ITYRKLLDLVCQFANGLLAKGIRKGDRVA 141
N +DR+V G G + A ++ NSP T+ ITY LL V A L G++KGD V
Sbjct: 68 NCVDRHVAAGNGHESAIYY--NSPVTNTKETITYHTLLREVETLAGVLRETGVKKGDVVM 125
Query: 142 VYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGERMY 201
+YMPMI A+I MLA R+GAVH+VVF GF+ +ALA+R+ K +L+TA G R
Sbjct: 126 LYMPMIPAALIGMLAVNRLGAVHSVVFGGFAPNALAQRVEACKPDVLLTASCGIVGNRPP 185
Query: 202 V-YKRTCDDAIE 212
+ Y+ ++AI+
Sbjct: 186 IAYQALVEEAIK 197
>UniRef50_A3WE14 Cluster: Acetyl-coenzyme A synthetase; n=1;
Erythrobacter sp. NAP1|Rep: Acetyl-coenzyme A synthetase
- Erythrobacter sp. NAP1
Length = 1850
Score = 209 bits (510), Expect = 2e-52
Identities = 162/459 (35%), Positives = 224/459 (48%), Gaps = 51/459 (11%)
Query: 274 VAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITG 333
V AE P F++YTSGSTGKPKGVVH GY AAT F DV + AD GWITG
Sbjct: 429 VDAEYPNFIIYTSGSTGKPKGVVHVHGGYASGVAATMPAAFGAEPGDVMYVVADPGWITG 488
Query: 334 HTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAH-YNVE 392
+Y + A L + T+V+ EG+P FP R+ SII +Y V F T ++++M + N++
Sbjct: 489 QSYQIAASLLSRVTTVITEGSPVFPHAGRFASIIERYGVNVFKAGVTFLKSVMQNPENLK 548
Query: 393 DGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTETGGHVITGLPG 452
D + DLSSL+V EP++PA + I ++++W TE GG V T
Sbjct: 549 D--IQRYDLSSLKVATFCAEPVSPAVQAFAMEHITHR---YINSYWATEHGGMVWTHFAD 603
Query: 453 ATPMKPGAAEKKHPVYYSSMDTFRPKQGWDRTVMIVHLPNKSNRTRGFPFFGVEPKILNE 512
A A +P+ + D + + D + + P + R G G P + E
Sbjct: 604 ADGFPLEADAHTYPLPWIMGDVW--VEDADGS---SNGPVEYERDTG---TGGAPWRVAE 655
Query: 513 DGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRF--ERV--------------------YF 550
DG +G +V A P+P + RT+ D + F E V Y+
Sbjct: 656 DG------EKGEIVIALPYPYLTRTIWGDVENFTVEHVGNLARVAGGWRGDEVRYADTYW 709
Query: 551 SKFPG--YYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVL----ASDPR-- 602
++ G Y GD R DG + GR DD++NVSGH + T E+EG + A DP
Sbjct: 710 RRWKGAWAYTQGDFAMRHPDGSFSLHGRSDDVINVSGHRIGTEEIEGAILRDKALDPNSP 769
Query: 603 VSEAAVVPKPHEVKGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPG 662
V V+ PH KG FV EG + D + LT LVR + GA A P
Sbjct: 770 VGNVIVIGAPHSQKGVTPIAFVTPVEGRRLTQDDKRRLTDLVRTEKGAVAVPQDFIELSE 829
Query: 663 LPKTRSGKIMRRILRKIAVGDHEVGDISTLADPGVVEEL 701
P+TRSGK MRR++R + G EVGD STL +P ++EL
Sbjct: 830 FPETRSGKYMRRMVRAVVEGG-EVGDASTLRNPESLDEL 867
Score = 88.6 bits (210), Expect = 5e-16
Identities = 53/149 (35%), Positives = 83/149 (55%), Gaps = 11/149 (7%)
Query: 72 KFMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGN-----------SPDDYTRITYRKLLD 120
++ E + +N +DR+V +G GD+ A +EG+ P D I+ RKLL
Sbjct: 110 RWFEGGLTSTAFNEVDRHVLSGHGDEAAMIFEGDRWNMASEGGRGGPVDSEVISRRKLLL 169
Query: 121 LVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERL 180
+ A L A G+ GDR+A+ MP I E + R+G V+T VF GFS L++R+
Sbjct: 170 ESAKCALALKALGLEAGDRIALNMPSIPEQIYWTEGAKRMGIVYTPVFGGFSDKTLSDRI 229
Query: 181 SDAKAKLLVTADGAWRGERMYVYKRTCDD 209
+DA A+++VTADG++R +M +K + D
Sbjct: 230 ADAGARVVVTADGSYRNAQMVPFKPSYTD 258
>UniRef50_A5UY60 Cluster: AMP-dependent synthetase and ligase; n=2;
Roseiflexus|Rep: AMP-dependent synthetase and ligase -
Roseiflexus sp. RS-1
Length = 1912
Score = 208 bits (508), Expect = 4e-52
Identities = 146/445 (32%), Positives = 217/445 (48%), Gaps = 31/445 (6%)
Query: 276 AEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHT 335
AE PLF++YTSGSTGKPKGVVH GY+ A T + FD D + AD GWITG +
Sbjct: 420 AEYPLFIIYTSGSTGKPKGVVHVHGGYVAGVAHTMKVSFDAEPGDTIYVVADPGWITGQS 479
Query: 336 YVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAH-YNVEDG 394
Y++ A L T ++ EG+P FP R+ SII +Y V F T ++ +M+ N D
Sbjct: 480 YMICATLTTRCTGIITEGSPVFPSAGRFASIIERYGVRIFKAGVTFLKTVMSDPQNTADA 539
Query: 395 NLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCS--IVDTFWQTETGGHVITGLPG 452
D+SSLRV EP++PA + G E S ++++W TE GG V T G
Sbjct: 540 R--QYDMSSLRVCTFCAEPVSPAV-----QQFGMELMSPQYINSYWATEHGGIVWTHFYG 592
Query: 453 AT--PMKPGAAEKKHPVYYSSMDTFRPKQGWDRTVMIVHLPN---KSNRTRG-FPFFGVE 506
P++P A +P+ + + + + +G DR P +G
Sbjct: 593 NEDFPLRPDA--HTYPLPWIAGEVW-VLEGGDRDASGAEAPRYRIADYEEKGEIVITAPY 649
Query: 507 PKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLE-DQDRFERVYFSKFPG---YYCTGDG 562
P + +++G E ++ + G D +RF + Y+ + P Y GD
Sbjct: 650 PYLTRTIWGDVKG-FEAWVAALQSGNGAAAPRWRGDAERFVKTYWRRGPNGEWGYIQGDF 708
Query: 563 VRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEG------VLASDPRVSEAAVVPKPHEVK 616
+ DG + GR DD++NVSGH M T E+EG ++ D V VV PH K
Sbjct: 709 AMKYPDGSFTLHGRSDDVINVSGHRMGTEEIEGAILRDKIITPDSPVGNCIVVGAPHREK 768
Query: 617 GEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRIL 676
G F++ G + ++ + L LVR + GA + P+ P+TRSGK MRR L
Sbjct: 769 GLTPVAFILTAPGRKLTSEDRRRLNELVRNEKGAVSVPEDYIEVSAFPETRSGKYMRRFL 828
Query: 677 RKIAVGDHEVGDISTLADPGVVEEL 701
R + + D +GD +TL +P ++E+
Sbjct: 829 RNLML-DEPLGDTTTLRNPESLKEI 852
Score = 101 bits (243), Expect = 5e-20
Identities = 54/156 (34%), Positives = 93/156 (59%), Gaps = 12/156 (7%)
Query: 70 FVKFMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTR-----------ITYRKL 118
F ++ E N C+N +DR+V G+GD++AF++EG+ D +T ++L
Sbjct: 98 FYRWFEGGLTNACFNEVDRHVLTGYGDEVAFYFEGDRWDSSLNNGRGGPVVSFAVTRKQL 157
Query: 119 LDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAE 178
+ V + A L G++ GDR+A+ MP I+E + A R+G ++T VF GFS L++
Sbjct: 158 MLEVVKAAQVLRDLGLKTGDRIALNMPNIMEQIYYTEAAKRLGIIYTPVFGGFSDKTLSD 217
Query: 179 RLSDAKAKLLVTADGAWRGERMYVYK-RTCDDAIEK 213
R+ +A A+L++T+DGA+R ++ YK + D A++K
Sbjct: 218 RIHNAGARLVITSDGAYRNAQVVAYKEQYTDQALDK 253
>UniRef50_Q5BYW0 Cluster: SJCHGC03435 protein; n=1; Schistosoma
japonicum|Rep: SJCHGC03435 protein - Schistosoma
japonicum (Blood fluke)
Length = 206
Score = 207 bits (505), Expect = 9e-52
Identities = 90/193 (46%), Positives = 133/193 (68%)
Query: 8 PTDHVIKKSYLPSIQKYKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKG 67
P++ + K +++ S +++K + +++L+ + FW A +F W P + YNFD G
Sbjct: 6 PSESIRKSAHVKSEEEHKWLSDKALSNPKEFWLGYAMKFDWKPHPSFEKCLSYNFDCRMG 65
Query: 68 RVFVKFMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFAN 127
+F+K+ E+ N+CYN+LDRN+ GFGDK+A WEGN P+D T++TY ++L V +
Sbjct: 66 PIFIKWFEDGYTNICYNILDRNIDRGFGDKVAILWEGNDPNDTTQLTYSEMLFKVKRIGK 125
Query: 128 GLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKL 187
L GIRKGD VA+YMPM+ E ++ MLACARIGAVH+V+F GFS+ ALA R+ DAK K+
Sbjct: 126 MLENFGIRKGDCVAIYMPMVPELIMTMLACARIGAVHSVIFGGFSACALAGRIMDAKCKI 185
Query: 188 LVTADGAWRGERM 200
L+TADG WRG ++
Sbjct: 186 LITADGTWRGSKL 198
>UniRef50_Q54YU1 Cluster: Putative uncharacterized protein; n=1;
Dictyostelium discoideum AX4|Rep: Putative
uncharacterized protein - Dictyostelium discoideum AX4
Length = 661
Score = 196 bits (479), Expect = 1e-48
Identities = 179/661 (27%), Positives = 302/661 (45%), Gaps = 76/661 (11%)
Query: 79 LNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGD 138
LN CYN LD+++ NG G++IAF E S T+ITY++L D VC+F+ L GI+KGD
Sbjct: 26 LNACYNALDKHIVNGGGEEIAFVHEIPSKQISTQITYKQLFDKVCKFSRSLKNLGIKKGD 85
Query: 139 RVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLS----------------- 181
V +YM +E +I L+C RIGA H ++F G++ L + L+
Sbjct: 86 IVIIYMHNSIELIISALSCCRIGATHNIIFGGYTQKGLTDLLNIYSPTPTPTPTPTPTPT 145
Query: 182 -------DAKAKLLVTAD-GAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDR 233
+ KL++T++ G + Y YK + I + ++ N D
Sbjct: 146 PTPTPNFNQSPKLIITSNYGLLNNDIYYFYKEIIESLINS-----NLNLKNIILFNRND- 199
Query: 234 VTPGGSLKSEIKDLYNWNEETDIW-WHEVLEGE--SNICPPEWVAAEDPLFVLYTSGSTG 290
G+ K+ + N N +I+ W++++ G + E V + P++V+ TSG+T
Sbjct: 200 YNNNGNNKNNNNNNQNNNHNFNIFDWNDLVNGGDIEPLLEYELVESNHPIYVMNTSGTTS 259
Query: 291 KPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVM 350
KPK +V TAG++ + + +F ++ D Y + +GW++GH+ ++Y L + SV
Sbjct: 260 KPKAIVRETAGHIASLCYSVKNIFKLNKGDTYLSLSSIGWVSGHSTLLYGCLFSGCKSVF 319
Query: 351 FEG-----TPYFPKVDRYWSIINKYKVTQFYTAPTAIRAL-MAHYNVEDGNLTMP-DLSS 403
EG KV +WS+I KY V F T P + + M N G + +L
Sbjct: 320 IEGPLNENDNDTEKVRMFWSLIEKYNVNVFPTTPHQMNLIKMVDPN---GEIRFQFNLKH 376
Query: 404 LRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTETGGHVITGLPGATPMKPGAAEK 463
L+ + S+G + Y T K SI+ +WQTE+G PM + E
Sbjct: 377 LKHV-SIGSEKVYEKTINYLTNTLK--LSIIIDYWQTESG----------FPMIYNSTEN 423
Query: 464 KHPVYYSSMDTFRPKQGWDRTVMIVHLPNKSNRTRGFPFFGVEPKILNEDGVEIEGPGEG 523
+ S+D K + IV N +N+T I N++ + GE
Sbjct: 424 DLNLKNCSVDAI-GKVAPGYNIKIVSKINNNNQT---------SVIENKENEK----GEI 469
Query: 524 YLVFARPWPGMMRTLLED-QDR--FERVYFSKFPGYYCTGDGVRRDEDGYLWITGRIDDM 580
+ F P PG+ L D DR +++ Y ++F GY+ T D DE+ + + R DD
Sbjct: 470 VIKFPLP-PGLCNCLFGDTNDRLLYKQHYLNEFEGYFRTKDIGYFDENKVWYFSSRSDDS 528
Query: 581 LNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALYCFVVLKEGLQFDADLVKTL 640
++ ++++ +E ++ +SE+ V+ E+ G+ + +VL+ L +
Sbjct: 529 ISYGSVIVNSGVLENLILKIQNISESCVIGIDDEIHGQEIAAILVLENKNIDTISLKNEI 588
Query: 641 TLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKIAVGDHEVGDISTLADPGVVEE 700
+V+ + I LPKTR+GK ++ +L I + TL D V++E
Sbjct: 589 NNIVKTNLFTCINIKYIIIVKRLPKTRTGKRIKSLLTSIFNNKSYIIP-PTLQDDIVIDE 647
Query: 701 L 701
L
Sbjct: 648 L 648
>UniRef50_Q0FW37 Cluster: Acyl-CoA synthetase; n=1; Roseovarius sp.
HTCC2601|Rep: Acyl-CoA synthetase - Roseovarius sp.
HTCC2601
Length = 656
Score = 193 bits (471), Expect = 1e-47
Identities = 135/425 (31%), Positives = 205/425 (48%), Gaps = 29/425 (6%)
Query: 25 KEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRVFVKFMEEAELNVCYN 84
++M+ S+ + E FW + F D + G F ++ LNV +
Sbjct: 40 EDMHRASIDDPESFWPRALDDLGVTFTTPWSTFR----DDSAGFAFPRWFSGGALNVATH 95
Query: 85 LLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAVYM 144
+ R+ K+ K +++ L V + A GL A GI KGDRV +++
Sbjct: 96 CVTRHAKDPEAAKRPAVISEADSGVCRELSFGALGAEVERVAAGLAALGIGKGDRVGLFL 155
Query: 145 PMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGERMYVYK 204
P+I EA + ++ACA+IGAV F+G+ D LA RL+ A A LVT DG R + K
Sbjct: 156 PVIPEAAVALMACAKIGAVAVPAFSGYGPDPLAARLNAADAVALVTVDGTTRKGKPVAMK 215
Query: 205 RTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIWWHEVLEG 264
T D A+++A +H +V+ + T G +E +D + W DI + +
Sbjct: 216 ETADGALKQAPGV-RH----VLVIEN----TGSGCAMTEGRD-HAW---ADIG--KACDP 260
Query: 265 ESNI-CPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYW 323
+ C P DP ++YTSG+TG PKG+VH+ AGYL+ + F Y FD D+
Sbjct: 261 VPTVACDPN-----DPFMIIYTSGTTGAPKGIVHSHAGYLIKSGVDFGYAFDVQSDDLVG 315
Query: 324 CTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIR 383
AD+GW+ G ++ L A V EG P FP +R W I+ +++VT APTA R
Sbjct: 316 WIADMGWMLG-PLMITGCLQFGAGIVFVEGLPNFPDHNRMWDIVERHRVTMLGMAPTAAR 374
Query: 384 ALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTETG 443
L A G + D+SSLR S GE + W W + +G + I++ TETG
Sbjct: 375 GLRA---AMAGGVPEQDISSLRAFTSTGEAWDEPTWWWLFRDVGGKTLPIINYTGGTETG 431
Query: 444 GHVIT 448
G +++
Sbjct: 432 GGILS 436
Score = 124 bits (298), Expect = 1e-26
Identities = 72/192 (37%), Positives = 101/192 (52%), Gaps = 5/192 (2%)
Query: 501 PFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYCTG 560
P G + +L+ +G +G GE L WPGM +D +R+ Y+S FP + G
Sbjct: 451 PLPGQDADVLDAEGNPTDGIGE--LAVHNTWPGMTHAFWQDPERYFETYWSTFPDTWVHG 508
Query: 561 DGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEAL 620
D DGY I GR DD + VSG + AE+E L ++P VSEAAV+ P +G +
Sbjct: 509 DLASVAGDGYWRIHGRSDDTIKVSGRRIGPAEIESALVTNPEVSEAAVIGVPDPDRGSRI 568
Query: 621 YCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKIA 680
FV L G++ D+V+ + R +G P I PGLPKT++GKIMRR +R
Sbjct: 569 VAFVTLGSGVE-ALDMVRAAEAVTR-LVGKAMIPSLIVPVPGLPKTKNGKIMRRAIRARY 626
Query: 681 VGDHEVGDISTL 692
+G GD+S L
Sbjct: 627 LG-QPAGDMSAL 637
>UniRef50_Q39MW7 Cluster: AMP-dependent synthetase and ligase; n=1;
Burkholderia sp. 383|Rep: AMP-dependent synthetase and
ligase - Burkholderia sp. (strain 383) (Burkholderia
cepacia (strain ATCC 17760/ NCIB 9086 / R18194))
Length = 668
Score = 192 bits (467), Expect = 4e-47
Identities = 133/437 (30%), Positives = 204/437 (46%), Gaps = 28/437 (6%)
Query: 24 YKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRVFVKFMEEAELNVCY 83
Y+++ E + T + +W+ + + + D G + K+ N
Sbjct: 41 YRQLLEFAETRPDDYWSALIRHMDLRFYQPYDAVV----DTRDGIEWAKWCVGGTTNAVL 96
Query: 84 NLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAVY 143
N LDR + A WEG R TY +L + A GL G R+GD +A+Y
Sbjct: 97 NCLDRYRGTARDRQEAVVWEGED-GTVRRWTYAELDAQTSRLAAGLREIGCRQGDVIALY 155
Query: 144 MPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGERMYVY 203
+PM+ EAV MLA ++IGA+ +F+GF + A+A RL DA A ++TAD + R ++
Sbjct: 156 LPMVPEAVAGMLAISKIGAIVLPLFSGFGAQAVASRLQDAGAVAVLTADASTRRGKVTPL 215
Query: 204 KRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIWWHEVLE 263
K+T D A T KH V V+ H T W+ D WHE+++
Sbjct: 216 KQTIDAARADVPT-LKHVV----VLRHRGAET-------------EWDARVDHEWHELID 257
Query: 264 GESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYW 323
G+ P + A+ P+ ++YTSG+TGKPKG VH+ G + A D D
Sbjct: 258 GQPTDAPTTEMPADAPMMLMYTSGTTGKPKGTVHSHCGLITKLALDMGLCADMRAGDRLM 317
Query: 324 CTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIR 383
+D+GW+ G ++Y T VM EG FP R+W ++ +++V+ APT +R
Sbjct: 318 WLSDMGWLVG-PMLIYGTTLLGGTIVMAEGAHDFPDSGRFWRLMEQHRVSVLGIAPTIVR 376
Query: 384 ALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTETG 443
+ M + DLS+LRV S GE AW W + ++ I++ TE G
Sbjct: 377 SFM---QAGGAGIENHDLSALRVALSTGEAWTVDAWRWMFDKVCGGSRPIINYSGGTEVG 433
Query: 444 GHVITGLPGATPMKPGA 460
G ++TG P+KP A
Sbjct: 434 GGIVTGTV-IHPLKPCA 449
Score = 112 bits (270), Expect = 3e-23
Identities = 66/201 (32%), Positives = 104/201 (51%), Gaps = 1/201 (0%)
Query: 501 PFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYCTG 560
P G+ ++++ G + G G L P G+ R L D +R+ Y+ G + G
Sbjct: 453 PIPGMGADVVDDAGRSVGPGGTGELALRAPSIGLTRGLWHDNERYLASYWGTTSGMWRHG 512
Query: 561 DGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEAL 620
D D DG+ ++ GR DD L V+G +E+E ++ + +V+EAA + P VKGE +
Sbjct: 513 DRAAIDADGFWYVLGRADDTLKVAGKRTGPSEIETLVMATGQVAEAAAIGVPDCVKGETV 572
Query: 621 YCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKIA 680
V L G+ DAD+ K L+ V +G P + LPKTR+ KIMRR +R
Sbjct: 573 GLVVTLMPGVPADADVEKALSAAVVSGLGTAFRPALVLFVDDLPKTRNMKIMRRAVRAAC 632
Query: 681 VGDHEVGDISTLADPGVVEEL 701
+G GD+S+LA+P ++ +
Sbjct: 633 LG-LPPGDLSSLANPETLDAI 652
>UniRef50_Q2RGI0 Cluster: Acetyl-coenzyme A synthetase; n=1;
Moorella thermoacetica ATCC 39073|Rep: Acetyl-coenzyme A
synthetase - Moorella thermoacetica (strain ATCC 39073)
Length = 329
Score = 189 bits (461), Expect = 2e-46
Identities = 109/269 (40%), Positives = 153/269 (56%), Gaps = 19/269 (7%)
Query: 41 EVAQEFQWHVAPKPGGFMKYNFDITKGRVFVKFMEEAELNVCYNLLDRNVKNGFGDKIAF 100
E A+EF A + F +++ + + LN YN LDR+V+ +K A
Sbjct: 40 ESAEEFWGREAARLHWFRRWDRVLEWDYPLAWWFNGGTLNASYNCLDRHVETWRRNKAAI 99
Query: 101 FWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARI 160
WEG P D +TYR L V +FA L + +++ DRVA+Y+PMI E I MLACARI
Sbjct: 100 IWEGE-PGDAVVLTYRDLYREVNKFAAVLRSLWVKRDDRVAIYLPMIPELPIAMLACARI 158
Query: 161 GAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGERMYVYKRTCDDAIEKARTFFKH 220
GAVH VVF GFS+ AL +R++D AK+L+TADG +R R+ K + D A++ A +
Sbjct: 159 GAVHNVVFGGFSAAALRDRINDTGAKILITADGGFRKGRIVGLKESADTALDGAPS---- 214
Query: 221 RVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIWWHEVLEGESNICPPEWVAAEDPL 280
++RV + + N + D+WWHE++ PPE + AEDPL
Sbjct: 215 ----------IERVI----VAKRTGERVNMHPGRDLWWHELMAAAPLYTPPEHMEAEDPL 260
Query: 281 FVLYTSGSTGKPKGVVHTTAGYLMYAAAT 309
F+L+TSG++GKPKGVVHTT GYL+ A T
Sbjct: 261 FILHTSGTSGKPKGVVHTTGGYLVGTATT 289
>UniRef50_A3W6I7 Cluster: AMP-dependent synthetase and ligase; n=2;
Rhodobacteraceae|Rep: AMP-dependent synthetase and
ligase - Roseovarius sp. 217
Length = 645
Score = 182 bits (443), Expect = 3e-44
Identities = 145/464 (31%), Positives = 218/464 (46%), Gaps = 40/464 (8%)
Query: 5 MYKPTDHVIKKSYLPSI------QKYKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFM 58
M++P+ + + S L + Y+++ R+ + FW + + +P ++
Sbjct: 1 MFQPSPDIQRSSTLAAFLADCAADSYEDLVRRANAAPDWFWRRIIDHAGIRFS-RP--YL 57
Query: 59 KYNFDITKGRVFVKFMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRI-TYRK 117
+ DI KG +++ A LN+ LD ++ G DK+ W G D R TY +
Sbjct: 58 QLR-DIFKGPESIRWAVGAALNLTETCLDARIEEGLADKMVIDWVGE--DASRRCWTYAE 114
Query: 118 LLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALA 177
L + A+ L A+G++ G+RV +YMPMI E +L AR+GAV +F+GF+ A+
Sbjct: 115 LAAETARVASALAARGVKPGERVGIYMPMIPEIAAALLGIARLGAVAVPLFSGFAPPAIV 174
Query: 178 ERLSDAKAKLLVTADGA-WRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTP 236
RL DA A ++TAD RG+ +++ + A+ +A T V V L R
Sbjct: 175 SRLQDAGAVAVLTADATPRRGKPVWM-----EAALAEALT----EVPAVHTVISLRRF-- 223
Query: 237 GGSLKSEIKDLYNWNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVV 296
GG + DL D+ W E + P V A+ PL + YTSG+TGKPKGVV
Sbjct: 224 GG----VVADL-----ARDLDWQESVGKADPTRPAHPVEADAPLLIAYTSGTTGKPKGVV 274
Query: 297 HTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPY 356
HT G A A F D R D + D+GW+ G + + L + AT V+ EG P
Sbjct: 275 HTHLGVPAKATADFLLCLDMKRDDRHLWMTDMGWVMG-PLTLLSVLLSGATLVLAEGAPS 333
Query: 357 FP-KVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPIN 415
P R I KVT APT +R M H + L+ DLS LR++ + GEP
Sbjct: 334 MPGDPFRLLRITADMKVTHLGIAPTLVRQFMTH---DPAPLSGYDLSPLRIVAATGEPWT 390
Query: 416 PAAWLWYYTRIGKERCSIVDTFWQTETGGHVITGLPGATPMKPG 459
AWLW+ I + ++ TE G ++T +KPG
Sbjct: 391 DDAWLWHLDHICRRHAVPLNISGGTELFGAILTSTV-LHEIKPG 433
Score = 134 bits (325), Expect = 6e-30
Identities = 78/203 (38%), Positives = 114/203 (56%), Gaps = 3/203 (1%)
Query: 504 GVEPKILNEDGVEIEGPGE-GYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYCTGDG 562
GV K+L EDG E PGE G LV ++P G+ + D++R+ Y+S FPG + GD
Sbjct: 441 GVGAKVLREDGSEA-APGEVGELVVSQPPMGLTPAIWGDRERYLETYWSTFPGVWRHGDW 499
Query: 563 VRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALYC 622
VRRD DG +I GR DD LN++G + E+E L V +AA + P ++KG A+ C
Sbjct: 500 VRRDPDGTWYILGRSDDTLNIAGKRIGPPEIEAALTETGEVVDAAAIAAPDDIKGVAVVC 559
Query: 623 FVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKIAVG 682
V G+ DA LV L V + + P I LPKTRS K MRRI+R +G
Sbjct: 560 ICVAAPGVTPDAALVDRLKDRVGEVVSKPFRPREIHFVEALPKTRSMKTMRRIVRAAYLG 619
Query: 683 DHEVGDISTLADPGVVEELFNNR 705
+ + GD+S++++P ++ + + R
Sbjct: 620 E-DPGDLSSVSNPETMQPIADLR 641
>UniRef50_Q97WQ9 Cluster: Acetyl-CoA synthetase; n=3;
Sulfolobus|Rep: Acetyl-CoA synthetase - Sulfolobus
solfataricus
Length = 622
Score = 174 bits (424), Expect = 6e-42
Identities = 129/452 (28%), Positives = 217/452 (48%), Gaps = 40/452 (8%)
Query: 20 SIQKYKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRV-FVKFMEEAE 78
S+ + K + + S+ E FW + A W P+ I +G + K+
Sbjct: 7 SLDQIKALAKFSMENPEAFWRDKANYVSWFRQPEK---------ILEGEPPYEKWFVGGT 57
Query: 79 LNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGD 138
LN+ YN +DR++ + DK+AF+W D + I+++ L V + A L G++KGD
Sbjct: 58 LNISYNAIDRHLPDK-KDKVAFYWTNERLDSFRSISFQDLYQEVNKAAYVLSELGVKKGD 116
Query: 139 RVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGE 198
V++ MP I EAV LA R+GA+ + + G S + +A R +D +K+L+ A +R
Sbjct: 117 TVSMLMPNIPEAVYFSLATHRLGAILIIHYVGLSEETVAYRFNDCGSKVLIVASKTFRNG 176
Query: 199 RMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIWW 258
K D +E H + V+ P G D +N N + D+ +
Sbjct: 177 NEIRIKDFVDKVLES------HTTPIQKVLT-----VPRG-----YSD-FNVNGKRDVVY 219
Query: 259 HEVL-EGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYH 317
V +G+ + P E V A +P V YTSG+TG+PKG+ H+ GY++ F+ +F+
Sbjct: 220 DGVKPKGKVYVKPVE-VEANEPATVYYTSGTTGRPKGLYHSNGGYVIALNWAFKAIFNPT 278
Query: 318 RRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYT 377
DV+W +++GW +Y V+FEG + K D + +I +Y V+ ++
Sbjct: 279 ENDVWWTVSELGWPVWPMANLYTIPVMGIPGVLFEGYVGY-KRDLFSRVIERYNVSLVWS 337
Query: 378 APTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTF 437
+ T + L ++ + ++ D SSLR++ + GEP+N AW+W + + I D +
Sbjct: 338 STTTLYTLK---SLGEESVKSGDTSSLRMILNTGEPLNVGAWMWLNQNL--PQVKIADAY 392
Query: 438 WQTE---TGGHVITGLPGATPMKPGAAEKKHP 466
W TE G G+ G P K G+A + P
Sbjct: 393 WMTEHLSPVGATPYGI-GEIPFKAGSAGIQFP 423
Score = 113 bits (273), Expect = 1e-23
Identities = 68/194 (35%), Positives = 110/194 (56%), Gaps = 10/194 (5%)
Query: 509 ILNEDGVEIEGPGEGYLVFARPWPGMMRTLLE-DQDRFERVYFSKFPGYYCTGDGVRRDE 567
I++++G + +GY+V P + + + + ++ + Y+S+FPGY+ TGD DE
Sbjct: 430 IVDDEGKPLPPKQKGYIVLKPLNPALAKMWNDPNYEKIKEKYWSRFPGYFYTGDYGYVDE 489
Query: 568 DGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALYCFVVLK 627
DGYL++ GR DD++ G + T EVE V+ + P V+EAAV+ +G + FVV +
Sbjct: 490 DGYLFVLGRADDVIRAEGERIGTLEVESVIVTHPNVAEAAVIG-----QGGNIIAFVVPR 544
Query: 628 EGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKIAVGDHEVG 687
+G++ L + R A D + LPKT+SGKIMRR+L+ I ++ G
Sbjct: 545 QGVEVGDALRNDIKNYCR---NAGYIVDKVVFVKRLPKTKSGKIMRRLLKAILANENP-G 600
Query: 688 DISTLADPGVVEEL 701
D+STL D ++EEL
Sbjct: 601 DVSTLDDIRIMEEL 614
>UniRef50_Q39MD9 Cluster: AMP-dependent synthetase and ligase; n=2;
Burkholderia|Rep: AMP-dependent synthetase and ligase -
Burkholderia sp. (strain 383) (Burkholderia cepacia
(strain ATCC 17760/ NCIB 9086 / R18194))
Length = 650
Score = 167 bits (407), Expect = 7e-40
Identities = 126/457 (27%), Positives = 209/457 (45%), Gaps = 34/457 (7%)
Query: 12 VIKKSYLPSIQKYKEMYERSLTESELFWTEVAQE--FQWHVAPKPGGFMKYNFDITKGRV 69
++K + Y E+ S+ E E +W V +E W V P G++ D+++G
Sbjct: 22 IVKLMRALDVSSYDELMRVSIAEPERYWDTVMRECAIAWDVPPT--GYV----DLSRGAQ 75
Query: 70 FVKFMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGL 129
F + +LN + + A E + +T+ +L V FA GL
Sbjct: 76 FPSWFPGGKLNWVNTIYAWARHPATAQQKAVVAE-REDGSVSTLTFAELEQRVQDFAAGL 134
Query: 130 LAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLV 189
G+++GDR+ + M +EA + +LA +GA+ +F+GF DA+ RLS A+A++++
Sbjct: 135 ARHGVKQGDRIGLLMENGVEATVSLLAIVHLGALVVPLFSGFGVDAIVARLSAAEARMVI 194
Query: 190 TADGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYN 249
+ G R + + DA + ++ H+ G + +DL +
Sbjct: 195 ASTGFSRRTKRVDVQGALRDAWRQLP-----------LLEHVIWKRGEGDTAQDARDL-D 242
Query: 250 WNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAAT 309
W +ET E ++ P + P V+YTSG+TGKPKGVVHT + + A
Sbjct: 243 W-QETAAAAPEQRSAAVSVTP------DTPFMVIYTSGTTGKPKGVVHTHGSFPIKIAHD 295
Query: 310 FRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINK 369
FD DVY AD+GWI G T V+ L AT V ++G P +P R ++ +
Sbjct: 296 SLIHFDVQPGDVYCWPADMGWIAG-TLVLGCALLRGATLVCYDGAPDYPDWSRMSRVVER 354
Query: 370 YKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKE 429
++VT F +APT IR + +H + D S++R+L + GE I P + W+ R G
Sbjct: 355 HRVTHFGSAPTLIRGMASH----EALALAGDRSTVRLLITAGEGIAPEHFNWFLQRFGDG 410
Query: 430 RCSIVDTFWQTETGGHVITGLPGATPMKPGAAEKKHP 466
+++ TE G ++ +P P+ P P
Sbjct: 411 TAPVINYTGGTEASGALLASVP-IRPIPPSGFNTVSP 446
Score = 111 bits (267), Expect = 6e-23
Identities = 68/199 (34%), Positives = 102/199 (51%), Gaps = 3/199 (1%)
Query: 504 GVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYCTGDGV 563
GV ++N DG + G G L P+ GM + D +R+ Y+ PG + GD
Sbjct: 447 GVAADVVNADGQSVTGE-VGELAIRAPFVGMTHSFWRDDERYLETYWQTIPGIWVHGDLA 505
Query: 564 RRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALYCF 623
R DG ++ GR DD L V+G + AEVE V+ V+EAA + KG+ L F
Sbjct: 506 LRTPDGNYFMMGRSDDTLKVAGKRLGPAEVEEVVLELHDVAEAAAIGVADADKGQKLVVF 565
Query: 624 VVLKEGLQFD-ADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKIAVG 682
+V K G A+L ++ V +++G P + LPKTRS KIMRR++R + G
Sbjct: 566 IVPKPGTAVAVAELETLVSGHVDKRLGRPFRPGRVHVVAQLPKTRSSKIMRRVIRSVYCG 625
Query: 683 DHEVGDISTLADPGVVEEL 701
GD+S+L +P ++E+
Sbjct: 626 -QPPGDLSSLDNPAALDEV 643
>UniRef50_Q7WPR9 Cluster: AMP-binding enzyme; n=5;
Burkholderiales|Rep: AMP-binding enzyme - Bordetella
bronchiseptica (Alcaligenes bronchisepticus)
Length = 649
Score = 167 bits (406), Expect = 9e-40
Identities = 124/435 (28%), Positives = 205/435 (47%), Gaps = 30/435 (6%)
Query: 24 YKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRVFVKFMEEAELNVCY 83
Y ++ S+ E E +W V +E P G++ D+ +G F + LN
Sbjct: 35 YDDLMRVSVEEPERYWNTVMRECAIAWDEPPTGYV----DLARGPQFPSWFPGGRLNWVN 90
Query: 84 NLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAVY 143
+ + A E +TY++L V +FA GL G R GDR+ +
Sbjct: 91 TIYAWARNPATAGQTAVIGE-REDGSVGSLTYQELETRVREFAAGLARHGARPGDRIGLL 149
Query: 144 MPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGERMYVY 203
M ++A + +LA +GA+ +F+GF DA+ RLS A+A++++ + G R +
Sbjct: 150 MENGVDATVSLLAIVHLGALVVPLFSGFGVDAIVARLSAAEARMVIASTGFQRRTKRVDV 209
Query: 204 KRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIWWHEVLE 263
+ DA + + ++ N + + G S + + +DL +W + +
Sbjct: 210 QGALRDAWRQ----------LPLLENVVWKRADGESAQDQ-RDL-DWQQIAT-----AAQ 252
Query: 264 GESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYW 323
G+ P V + P V+YTSG+TGKPKGVVHT + + A FD H DVY
Sbjct: 253 GQGQ--DPVSVTPDTPFMVIYTSGTTGKPKGVVHTHGSFPIKIAHDSLVHFDVHPGDVYC 310
Query: 324 CTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIR 383
AD+GWI G T V+ L AT V ++G P +P R ++ ++KVT F +APT IR
Sbjct: 311 WPADMGWIAG-TLVLGCALLRGATLVCYDGAPDYPDWSRMSRVVERHKVTHFGSAPTLIR 369
Query: 384 ALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTETG 443
+ ++ + D +++RVL + GE I P ++W+ R G +V+ TE
Sbjct: 370 GMASNETL----ALAGDRATVRVLITAGEGIAPEHFIWFQQRFGDGSAPLVNYTGGTEVS 425
Query: 444 GHVITGLPGATPMKP 458
G +++ +P P+ P
Sbjct: 426 GALLSSVP-IRPIPP 439
Score = 112 bits (269), Expect = 4e-23
Identities = 66/199 (33%), Positives = 103/199 (51%), Gaps = 3/199 (1%)
Query: 504 GVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYCTGDGV 563
GV +++ DG + G G L P+ GM ++ D R+ Y+ PG + GD
Sbjct: 448 GVAVDVVDPDGHSVTGE-VGELAVRAPFVGMTQSFWHDDARYLETYWQAIPGIWVHGDLA 506
Query: 564 RRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALYCF 623
R +GY ++ GR DD L V+G + AEVE V+ V+EAA + KG+ L F
Sbjct: 507 LRTPEGYFFMMGRSDDTLKVAGKRLGPAEVEEVVLELHDVAEAAAIGVADAAKGQKLVVF 566
Query: 624 VVLKEGLQFDADLVKTLTL-LVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKIAVG 682
VV + G+ D ++ + V +++G P + LPKTRS KIMRR++R + G
Sbjct: 567 VVPRPGVSVPDDALQAAVIGHVDKRLGRPFRPGRVHVVSQLPKTRSSKIMRRVIRSVYCG 626
Query: 683 DHEVGDISTLADPGVVEEL 701
GD+S+L +P ++E+
Sbjct: 627 -QPPGDLSSLDNPAALDEV 644
>UniRef50_Q0RXR5 Cluster: Acetate--CoA ligase; n=1; Rhodococcus sp.
RHA1|Rep: Acetate--CoA ligase - Rhodococcus sp. (strain
RHA1)
Length = 654
Score = 167 bits (405), Expect = 1e-39
Identities = 129/423 (30%), Positives = 196/423 (46%), Gaps = 31/423 (7%)
Query: 38 FWTEVAQEFQWHVAPKPGGFMKYNFDITKGRVFVKFMEEAELNVCYNLLDRNVKNGFGDK 97
FW+ VA Q +P FD K+ LN+ N +DR ++ G G+
Sbjct: 52 FWSYVADWLQLEWQREPTSV----FDQLDAPHNTKWFPGGALNITDNAVDRWIRAGRGND 107
Query: 98 IAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLAC 157
A WE R T+ +L + + A GL+ GI GD V + +PM+ EA + LAC
Sbjct: 108 TALSWELEDGSS-GRWTFSQLSLEIDRVARGLIDAGIGFGDTVGIQLPMVREAAVAQLAC 166
Query: 158 ARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGERMYVYKRTCDDAIEKARTF 217
A+IGA+ +F+GF + A+ +RL A AK + + G R R A+ T
Sbjct: 167 AKIGAISVPIFSGFGTAAVIDRLRIAGAKAHIMSSGFHRRGREVAIPADLPTALADLGT- 225
Query: 218 FKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNE-ETDIWWHEVLEGESNICPPEWVAA 276
+ +VV L P ++ +W+E T V E CP
Sbjct: 226 ----LTTTIVVPLLAHTLP-----VDLPGPVHWDELGTGTTEEPVAAAE---CP-----T 268
Query: 277 EDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTY 336
+ P+ + +TSG+TG PKGVV AG+ + A + + FD DV D GWI
Sbjct: 269 DHPMLIAFTSGTTGAPKGVVLGHAGFAVKAGSDAAFSFDIGPGDVSTWITDPGWIMSPII 328
Query: 337 VVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNL 396
V+ +A +A + ++ GTP +P DR W+++ + VT +PT IR+LM +D +
Sbjct: 329 VLGGLIAGSAVA-LYAGTPDWPDTDRIWNMVRELGVTMMGVSPTLIRSLMD----KDTHP 383
Query: 397 TMP-DLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTETGGHVITGLPGATP 455
+P D LRVL S GE P A+ W Y+R+G I++ TE G +++ A P
Sbjct: 384 EVPIDTGQLRVLASSGEAWTPDAYEWLYSRVGGGHIPIINYSGGTEVSGAILSNTT-AQP 442
Query: 456 MKP 458
+ P
Sbjct: 443 IHP 445
Score = 123 bits (297), Expect = 1e-26
Identities = 70/204 (34%), Positives = 113/204 (55%), Gaps = 3/204 (1%)
Query: 501 PFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYCTG 560
P G+ I++ DG + G G G L +P PGM T + DR+ Y++++ G + G
Sbjct: 451 PLPGMGADIVDSDGRSL-GRGLGELALRQPSPGMPLTFWANPDRYYSTYWNRWDGTWYHG 509
Query: 561 DGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEAL 620
D V D + ++ GR DD L ++G + AEVE V+ +V E+A + P ++KGEAL
Sbjct: 510 DWVEVDNNDIWYVRGRSDDTLKIAGKRLGPAEVESVVNGIDQVVESAAIGVPDDIKGEAL 569
Query: 621 YCFVVLKEGLQFD-ADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKI 679
F + E Q + A+L T+ V +++G P + LP+TRSGKI+RR++R +
Sbjct: 570 VVFARVAEAKQGEHAELPATIAAEVGRQLGKPLTPKQVHIVDSLPRTRSGKILRRVIRAV 629
Query: 680 AVGDHEVGDISTLADPGVVEELFN 703
+G+ GD S+L DP ++ + N
Sbjct: 630 YLGNPS-GDTSSLDDPAALDLIRN 652
>UniRef50_Q6L1R6 Cluster: Acetyl-coenzyme A synthetase; n=1;
Picrophilus torridus|Rep: Acetyl-coenzyme A synthetase -
Picrophilus torridus
Length = 214
Score = 164 bits (399), Expect = 6e-39
Identities = 82/210 (39%), Positives = 125/210 (59%), Gaps = 6/210 (2%)
Query: 499 GFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYC 558
G P G KI+++ G E++ G LV +P+P + R++ D +++ YFS FP +YC
Sbjct: 7 GLPLPGHAFKIIDDTGKEVKTGEAGTLVITKPFPSLARSIWNDHNKYINQYFSVFPNFYC 66
Query: 559 TGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGE 618
T D +D+ G++W+ GR DD++NVSGH +ST E+E + S P +SEAAV+ HE+KG
Sbjct: 67 TYDSAIKDKFGHIWVIGRTDDVINVSGHRISTMEMENSIMSVPDISEAAVIGIDHEIKGT 126
Query: 619 ALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRK 678
Y F K D +L ++ + IG FA P+ I P +PKTRSGKIMRR+L++
Sbjct: 127 VPYVFFTSK---NTDNELKNKISSAIESSIGRFAMPEKIIIIPEMPKTRSGKIMRRLLKE 183
Query: 679 IAVGDHEVGDISTLADP---GVVEELFNNR 705
I + GDI+ L +P +++ NN+
Sbjct: 184 IVMHGDVSGDITGLENPDSINIIKNAINNQ 213
>UniRef50_A4WKF4 Cluster: AMP-dependent synthetase and ligase; n=3;
Pyrobaculum|Rep: AMP-dependent synthetase and ligase -
Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321)
Length = 633
Score = 164 bits (398), Expect = 8e-39
Identities = 163/591 (27%), Positives = 247/591 (41%), Gaps = 71/591 (12%)
Query: 22 QKYKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRVFVKFMEEAELNV 81
++YK++Y+ SL FW A W +P + + V++ EL+
Sbjct: 27 EQYKKIYKESLKPE--FWAREASYLIWE---RPWTKL-----VEGDPPAVRWFVGGELSP 76
Query: 82 CYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVA 141
N++ ++ DK+A W G T TY L L +++ L A G+ KGD V
Sbjct: 77 YKNIVGKHAGTWIWDKVALIWRGEDGLIKT-FTYSDLDQLAARYSGALRALGVGKGDWVM 135
Query: 142 VYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGERMY 201
Y P E + MLA RIGA VF GF LA R+ D + +LLV D R +
Sbjct: 136 FYAPPTPEVIALMLAAVRIGAPFEPVFTGFGHGDLAMRIEDRRPELLVAVDAFPRKGKAI 195
Query: 202 VYKRTCDDAIEKARTFFKHRVDMCMVVNHL--DRVTPGGSLKSEIKDLYNWNEETDIWWH 259
K T D A++ KH V +VV + D GG + + D D+
Sbjct: 196 KVKETVDKALKLT----KH-VPKVLVVQRMGIDVELIGG--RDFVLD--------DV--- 237
Query: 260 EVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRR 319
+E E + V + PLF L+ G V H GYL AT R++ R
Sbjct: 238 SPVEAEEVV-----VESSHPLFGLHVGYDDGLGF-VAHGAGGYLAQTYATTRWI-GLRPR 290
Query: 320 DVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAP 379
D Y+CT GWITG TYV++ P + V++EG P +P D +WS++ Y V F T
Sbjct: 291 DTYFCTVLPGWITGITYVLFGPFMVGSAVVIYEGGPDYPSWDVWWSVLEDYAVNVFLTTA 350
Query: 380 TAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQ 439
A+R L + L +L L+++ + EP+ W W Y +G +D+ +
Sbjct: 351 GALRLLSRQ---DPKLLESHNLDMLKLILTTAEPMEVKYWKWAYHYVGTGTTPSIDSLPE 407
Query: 440 TETGGHVITGLPGATPMKPGAAEKKHPVYYSSMDTFRPKQGWDRTVMIVHLPNKSNRTRG 499
L G P+ H + + TF + P G
Sbjct: 408 K---------LSGRIPVI-------HMFIQTELGTF-VTGSLPNYAFVPVAPGSV----G 446
Query: 500 FPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPG-YYC 558
P G + ++++ G + G G LV RPWP M + Y K+ G Y
Sbjct: 447 PPMPGFDIDVVDDSGNPVRGR-PGQLVVKRPWPAM-------PVEYSAWYAEKWRGGVYY 498
Query: 559 TGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVV 609
GD +D ++ GR D ++ ++G+ +S A +E +AS P V +A V
Sbjct: 499 VGDMAVMADDMNIFPLGRSDTVMKINGYRISPAIIEKAVASLPGVEDAVAV 549
>UniRef50_Q6A9A4 Cluster: Acetyl-coenzyme A synthetase; n=1;
Propionibacterium acnes|Rep: Acetyl-coenzyme A
synthetase - Propionibacterium acnes
Length = 222
Score = 163 bits (395), Expect = 2e-38
Identities = 81/159 (50%), Positives = 96/159 (60%), Gaps = 5/159 (3%)
Query: 255 DIWWHEV--LEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRY 312
D W+ E+ L C V EDPLF+LYTSG TGKPK +VHT GY + T +
Sbjct: 67 DHWYDELCKLPIAKGKCETVQVDTEDPLFILYTSGFTGKPKAIVHTHGGYQVGTYITLKQ 126
Query: 313 VFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKV 372
FD D +WCTAD GWI GH+Y+VY PL N AT M EG P +P D +W +I Y +
Sbjct: 127 YFDIKEEDRWWCTADPGWINGHSYLVYGPLLNGATVFMHEGGPTYPYPDGWWQLIEHYGI 186
Query: 373 TQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVG 411
T FYTAPTAIR LM D + DLSSLR+LGSVG
Sbjct: 187 TSFYTAPTAIRTLM---RFGDAWVRKHDLSSLRILGSVG 222
Score = 53.6 bits (123), Expect = 2e-05
Identities = 32/85 (37%), Positives = 47/85 (55%), Gaps = 4/85 (4%)
Query: 126 ANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKA 185
AN L G+RKGD V +Y+P I E MLACA+IGAVH+ VF+ + + R + +
Sbjct: 2 ANVLKVMGVRKGDVVTIYLPRIPEIFFAMLACAKIGAVHS-VFSPTVENVIVVRNTKTEV 60
Query: 186 KLLVTADGAWRGE--RMYVYKRTCD 208
+ T D W E ++ + K C+
Sbjct: 61 SMDSTRD-HWYDELCKLPIAKGKCE 84
>UniRef50_UPI0000E4931E Cluster: PREDICTED: hypothetical protein,
partial; n=1; Strongylocentrotus purpuratus|Rep:
PREDICTED: hypothetical protein, partial -
Strongylocentrotus purpuratus
Length = 353
Score = 161 bits (391), Expect = 6e-38
Identities = 99/273 (36%), Positives = 150/273 (54%), Gaps = 30/273 (10%)
Query: 24 YKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYN--FDITKGRVFVKFMEEAELNV 81
Y +++ S+T+ E FW E A+ W F K++ D+T+ F+ ELN+
Sbjct: 60 YPQVFADSITQPEEFWAEQAERVVW--------FKKWDRVMDLTQSPASNWFVG-GELNM 110
Query: 82 CYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVA 141
CYN +DR+V G+GD+ A + T+ITY++L D V +FA L+ G++ GDRV
Sbjct: 111 CYNAVDRHVDEGYGDQDAIIHDSPVTGSVTKITYKELQDEVSKFAAALVKSGVKYGDRVL 170
Query: 142 VYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGERMY 201
+YMPMI +AV+ MLACARIGA+H +VF GF+S L+ R+ K K++V+A R+
Sbjct: 171 IYMPMIPQAVMAMLACARIGAIHVLVFGGFASKELSVRIDHVKPKVIVSASVGVEPGRIV 230
Query: 202 VYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIWWHEV 261
YK D+AI+ + + C++ N + T N+ D W E+
Sbjct: 231 DYKSLLDNAIDMCES----KPKACIIYNRPNFETA------------NFIPGRDFCWTEL 274
Query: 262 LEG-ESNICPPEWVAAEDPLFVLYTSGSTGKPK 293
+ + + C P V A DP+FVL+TSG+TG PK
Sbjct: 275 VSSVKGHDCVP--VKATDPIFVLHTSGTTGTPK 305
>UniRef50_Q9HLJ9 Cluster: Acetyl-CoA synthetase related protein;
n=2; Thermoplasma|Rep: Acetyl-CoA synthetase related
protein - Thermoplasma acidophilum
Length = 619
Score = 159 bits (387), Expect = 2e-37
Identities = 127/460 (27%), Positives = 216/460 (46%), Gaps = 59/460 (12%)
Query: 6 YKPTDHVIKKSYLPSIQK-----YKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKY 60
YKP+D I ++ L K++Y R+ + E FW V + K +
Sbjct: 4 YKPSDEAIAETNLGRFASSLGMTVKDLYARADRDPEWFWPRVIDDLGLEFFKK----FDH 59
Query: 61 NFDITKGRVFVKFMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDY-TRITYRKLL 119
D+++G + K+ +N+ YN ++R + + A +E S D Y ++++Y +L
Sbjct: 60 VMDLSEGVPWAKWFTGGRINIEYNAVERYSDS---ENTAIVYE--SEDGYKSKMSYSELN 114
Query: 120 DLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAER 179
V ++ + GI +GDRVA+YMP + I A RIGA+ +F+G+ DA+ R
Sbjct: 115 RKVSALSSAIHDMGIGRGDRVAIYMPFNANSAIAFYAVLRIGAIAVPMFSGYGVDAVRNR 174
Query: 180 LSDAKAKLLVTADGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGS 239
+ D+ + L++T+ Y+R K + +DM V ++ T
Sbjct: 175 IEDSGSSLMITSAS---------YRR-------KGKA-----IDMSAVARSINMKT---I 210
Query: 240 LKSEIKDLYNWNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTT 299
+ ++ D Y + + + G N+ P E ++EDP +LYTSG+TGKPKG VH
Sbjct: 211 MDADRTDFYR--------FEDAVSGGKNV-PVERTSSEDPAIMLYTSGTTGKPKGTVHVH 261
Query: 300 AGYLMYAAATFRYVFDYHRRDV-YWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFP 358
G L+ A +Y D DV +W T D+GW+ G + + A T +++G +P
Sbjct: 262 GGALVNIAKEVKYYMDLKENDVLHWIT-DLGWMMG-PWALIGTNALHGTIFLYDGAIDYP 319
Query: 359 KVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAA 418
DR + I++ VT +PT +R + T ++RV GS GEP + +
Sbjct: 320 DPDRIFDIVHDNGVTLLGLSPTVVRMIKFRG-------TSRTFDTVRVFGSTGEPWDEES 372
Query: 419 WLWYYTRIGKERCSIVDTFWQTETGGHVITGLPGATPMKP 458
W++ ++ +G+ R SI + T+ G + P A P KP
Sbjct: 373 WVYLFSILGRGRASISNISGGTDIIGCFLASNP-AIPQKP 411
Score = 112 bits (269), Expect = 4e-23
Identities = 70/198 (35%), Positives = 104/198 (52%), Gaps = 8/198 (4%)
Query: 504 GVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYCTGDGV 563
G+ I NE+G E+ GYLV P P M R L +++++ Y+SKF + GD
Sbjct: 419 GMNASIFNEEGREVYNT-VGYLVAKFPSPSMTRGLWNNREKYLETYWSKFKDIWFHGDFG 477
Query: 564 RRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALYCF 623
DE+GY ++ GR DD++ ++G + EVE ++ V+E AVV P VKGE L F
Sbjct: 478 EMDEEGYFYLYGRSDDVIKIAGKRVGPNEVEDMVMRVSGVTECAVVSIPDSVKGEVLAVF 537
Query: 624 VVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKIAVGD 683
V + GL + K + + +G P + +PKTR+GKIMRR++R G
Sbjct: 538 YVGEPGL--SGRIAKQIEV----GMGKPFTPAHVVRISRIPKTRNGKIMRRVIRSAFCG- 590
Query: 684 HEVGDISTLADPGVVEEL 701
VGD+S D V+ E+
Sbjct: 591 LPVGDVSNTDDGDVIREI 608
>UniRef50_Q8ZV30 Cluster: Acetyl-coenzyme A synthetase; n=6;
Thermoprotei|Rep: Acetyl-coenzyme A synthetase -
Pyrobaculum aerophilum
Length = 626
Score = 157 bits (380), Expect = 1e-36
Identities = 84/212 (39%), Positives = 119/212 (56%), Gaps = 3/212 (1%)
Query: 491 PNKSNRTRGFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYF 550
P K + G P G + + EDG EG LV WPGM R D R+ Y+
Sbjct: 413 PIKPSSFNG-PSIGTKAAVFTEDGRPAPPGVEGELVVLSVWPGMTRGFWRDPQRYLETYW 471
Query: 551 SKFPGYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVP 610
+K+PG + GD DE+G+ +I GR DD + V+G + AE+E VL + P V+E+A +
Sbjct: 472 NKWPGVWAHGDAAVVDEEGFFYILGRADDTIKVAGKRLGPAEIETVLNAHPAVAESACIG 531
Query: 611 KPHEVKGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIG-AFAAPDTIQNAPGLPKTRSG 669
PHE+KGE CFVVLK G + L + L L + +G AF A + I+ LPKTR+
Sbjct: 532 VPHEIKGEVPVCFVVLKPGYEPSEALRRELIKLTEEALGKAFGAVEDIRFVKMLPKTRNA 591
Query: 670 KIMRRILRKIAVGDHEVGDISTLADPGVVEEL 701
KIMRR++R + +G GD+S L +P +EE+
Sbjct: 592 KIMRRVIRAVYLG-RNPGDLSALENPEAIEEI 622
Score = 120 bits (290), Expect = 1e-25
Identities = 69/186 (37%), Positives = 100/186 (53%), Gaps = 10/186 (5%)
Query: 276 AEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHT 335
AEDP+ ++YTSG+TGKPKG VHT G+ + AAA + FD + D+GW+ G
Sbjct: 242 AEDPIMIIYTSGTTGKPKGTVHTHDGFPVKAAADVYFHFDVSEGETLSWVTDMGWMMG-P 300
Query: 336 YVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGN 395
++V+A + FEG P +PK DR W + ++KV A T R L + G
Sbjct: 301 WMVFAAYLLRGSMAFFEGAPDYPK-DRLWRFVERFKVNALGLAATLTRYLRS-----IGA 354
Query: 396 LTMP-DLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTETGGHVITGLPGAT 454
P L SL+ G+ GEPI+ +WLW Y R+G+ R I++ TE G ++ G
Sbjct: 355 AAEPGQLDSLKAFGNTGEPIDVESWLWLY-RMGRGRIPIINYSGGTEISGGIL-GCYVVR 412
Query: 455 PMKPGA 460
P+KP +
Sbjct: 413 PIKPSS 418
Score = 69.7 bits (163), Expect = 3e-10
Identities = 55/201 (27%), Positives = 99/201 (49%), Gaps = 23/201 (11%)
Query: 5 MYKPTDHVIKKS----YLPS--IQKYKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFM 58
+++P H +++S Y+ S I+ + + + E FW +E K G +
Sbjct: 3 LWRPEKHHLEESNVAKYITSHGIKGLDDFLSLTFDKPEEFWRSFEKEVL-----KLGWYE 57
Query: 59 KYN--FDITKGRVFVKFMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRI-TY 115
+Y D++KG + ++ ++N+ L D + + WEG D T + +Y
Sbjct: 58 EYIKVLDLSKGVQWPRWFVGGKINIADQLEDSS-------RPLVKWEGE--DGSTAVWSY 108
Query: 116 RKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDA 175
++L A+ L G+ KGDRVA++MPM+ E + ML R G V +F+GF +A
Sbjct: 109 SEVLYKAKAVASWLKRNGLEKGDRVAIFMPMVPEIIPVMLGAIRAGGVIVPLFSGFGKEA 168
Query: 176 LAERLSDAKAKLLVTADGAWR 196
+ RL D++AK + +D ++R
Sbjct: 169 IRVRLEDSEAKFVFASDISYR 189
>UniRef50_P39062 Cluster: Acetyl-coenzyme A synthetase; n=41;
cellular organisms|Rep: Acetyl-coenzyme A synthetase -
Bacillus subtilis
Length = 572
Score = 153 bits (371), Expect = 2e-35
Identities = 126/407 (30%), Positives = 192/407 (47%), Gaps = 47/407 (11%)
Query: 61 NFDITKGRVFVKFMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLD 120
+FD + + E +LN Y +DR+ ++ +K+A +++ D+ + T++++ +
Sbjct: 24 HFDWAEAEKHFSWHETGKLNAAYEAIDRHAESFRKNKVALYYKDAKRDE--KYTFKEMKE 81
Query: 121 LVCQFANGLLAKG-IRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAER 179
+ N L G + KGDRV ++MP E ML GA+ AG L E
Sbjct: 82 ESNRAGNVLRRYGNVEKGDRVFIFMPRSPELYFIML-----GAIKIGAIAG----PLFEA 132
Query: 180 LSDAKAKLLVTADGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGS 239
+ K D E V T + +E+ VD + H+ V GG
Sbjct: 133 FMEGAVK-----DRLENSEAKVVV--TTPELLERIP------VDKLPHLQHVFVV--GGE 177
Query: 240 LKSEIKDLYNWNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTT 299
+S ++ N++E + ES EW+ +D + YTSGSTG PKGV+H
Sbjct: 178 AESGT-NIINYDEAA--------KQESTRLDIEWMDKKDGFLLHYTSGSTGTPKGVLHVH 228
Query: 300 AGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPK 359
++ T ++V D D+YWCTAD GW+TG Y ++AP N AT+V+ G + P
Sbjct: 229 EA-MIQQYQTGKWVLDLKEEDIYWCTADPGWVTGTVYGIFAPWLNGATNVIVGGR-FSP- 285
Query: 360 VDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAW 419
+ ++ I + V +Y+APTA R LM D DL+SLR + SVGEP+NP
Sbjct: 286 -ESWYGTIEQLGVNVWYSAPTAFRMLM---GAGDEMAAKYDLTSLRHVLSVGEPLNPEVI 341
Query: 420 LWYYTRIGKERCSIVDTFWQTETGGHVITGLPGATPMKPGAAEKKHP 466
W + K I DT+W TETG +I P +KPG+ K P
Sbjct: 342 RWGHKVFNKR---IHDTWWMTETGSQLICNYP-CMDIKPGSMGKPIP 384
Score = 147 bits (355), Expect = 1e-33
Identities = 77/196 (39%), Positives = 112/196 (57%), Gaps = 3/196 (1%)
Query: 499 GFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYC 558
G P GVE I++ G E+ G L + WP MM T+ + +++E YF G+Y
Sbjct: 380 GKPIPGVEAAIVDNQGNELPPYRMGNLAIKKGWPSMMHTIWNNPEKYES-YFMP-GGWYV 437
Query: 559 TGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGE 618
+GD DE+GY W GR+DD++ SG + EVE L P ++EA V+ KP V+GE
Sbjct: 438 SGDSAYMDEEGYFWFQGRVDDVIMTSGERVGPFEVESKLVEHPAIAEAGVIGKPDPVRGE 497
Query: 619 ALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRK 678
+ F+ L+EG + L + + L V+Q + A AAP I+ LPKTRSGKIMRR+L+
Sbjct: 498 IIKAFIALREGFEPSDKLKEEIRLFVKQGLAAHAAPREIEFKDKLPKTRSGKIMRRVLKA 557
Query: 679 IAVGDHEVGDISTLAD 694
+ + GD+ST+ D
Sbjct: 558 WEL-NLPAGDLSTMED 572
>UniRef50_Q557A3 Cluster: Putative uncharacterized protein; n=2;
Dictyostelium discoideum|Rep: Putative uncharacterized
protein - Dictyostelium discoideum AX4
Length = 709
Score = 151 bits (366), Expect = 6e-35
Identities = 115/424 (27%), Positives = 204/424 (48%), Gaps = 35/424 (8%)
Query: 38 FWTEVAQEF-QWHVAPKPGGFMKYNFDITKGRVFVKFMEEAELNVCYNLLDRNVKN-GFG 95
FW EVA+ F W Y+ + ++ + + ELN CYN+LD ++KN
Sbjct: 24 FWDEVAKNFVHWD--------RMYDKVYSGDEIYPDWFKGGELNTCYNVLDIHIKNPAKR 75
Query: 96 DKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICML 155
D+ A +E ++TY +L + VC+F+ LL + K D V +YM +EA I ML
Sbjct: 76 DQDALIYECPFLKKTIKLTYYQLYEKVCEFSRALLNLNVSKNDNVIIYMANTVEAPIAML 135
Query: 156 ACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGERMYVYKRTCDDAIEKAR 215
+CARIGA + +F G+S +L +R+ KL++T + + + + +AIE++
Sbjct: 136 SCARIGATYCTLFDGYSVKSLIDRIETITPKLIITTNYGISNDEIITFTPNLKEAIEQSN 195
Query: 216 TFFKHRVDMCMVVNHLDRVTPGGSLK-SEIKDLYNWNEETDIWWHEVLEGESNICPPEW- 273
H +++++ D +L I + T W+ E+ + + N P +
Sbjct: 196 FKPNH-----IIIHNRDDGDYNANLTLKTIIETIPTIPNTLSWYDEIKKFKENNQSPFYD 250
Query: 274 ---VAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVF---DYHRRDV------ 321
V + PL++LYTSG+TG K VV + +L+ T R +F + + +
Sbjct: 251 YIPVDSSHPLYILYTSGTTGNAKAVVRSNGPHLVGVKYTCRCMFLNDEVNNNNTNSDLIK 310
Query: 322 YWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRY--WSIINKYKVTQFYTAP 379
++ + +GW+T H + +Y+ L+ +MFEG +Y W +I K+KV +F+ P
Sbjct: 311 FFSHSSIGWVTFHGF-LYSLLSTGNIFIMFEGGICELNQIKYQLWKVIEKHKVNKFFIGP 369
Query: 380 TAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQ 439
+IR L+ + L+ +LSSL + + + + + ++ K +I + Q
Sbjct: 370 KSIRLLIKDDPNAEFILSNYNLSSLNTILVGADVVEKSVANYIENKLKKSASNI---YGQ 426
Query: 440 TETG 443
TETG
Sbjct: 427 TETG 430
Score = 37.1 bits (82), Expect = 1.6
Identities = 23/93 (24%), Positives = 42/93 (45%), Gaps = 6/93 (6%)
Query: 523 GYLVFARPWP-GMMRTLLEDQDRFERVYFSKFPG-----YYCTGDGVRRDEDGYLWITGR 576
G LVF P P G T ++ ++F++++ + YY +GD +D+D I R
Sbjct: 558 GELVFKLPLPPGFALTFYKNNEQFKKLFKTNLLNMEKGYYYFSGDLAFKDQDNNFTIVSR 617
Query: 577 IDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVV 609
DD + + + + +E + P V E +
Sbjct: 618 SDDQIKIKSNKVQLNTIEISVLKHPLVLECCCI 650
>UniRef50_Q86AI5 Cluster: Similar to Bradyrhizobium japonicum.
Acetyl-coenzyme A synthetase; n=2; Dictyostelium
discoideum|Rep: Similar to Bradyrhizobium japonicum.
Acetyl-coenzyme A synthetase - Dictyostelium discoideum
(Slime mold)
Length = 606
Score = 149 bits (360), Expect = 3e-34
Identities = 118/386 (30%), Positives = 192/386 (49%), Gaps = 28/386 (7%)
Query: 38 FWTEVAQEF-QWHVAPKPGGFMKYNFDITKGRVFVKFMEEAELNVCYNLLDRNVKNG-FG 95
FW EVA++ W Y+ + ++ + + ELN CYN+LD ++KN
Sbjct: 20 FWDEVAKDLVYWD--------RMYDKVYSGDEIYPDWFKGGELNTCYNVLDIHIKNPETR 71
Query: 96 DKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICML 155
D+ A +E + ++TY + + VC+F+ LL I K D V +YM +EA I ML
Sbjct: 72 DQTALIYECPFLNKNIKLTYYQFYEKVCEFSRVLLNLNISKNDNVLIYMSNTIEAPIAML 131
Query: 156 ACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGERMYVYKRTCDDAIEKAR 215
+CARIGA H V+F G+S +L +R+ KL++T + + + + DAIE +
Sbjct: 132 SCARIGATHCVLFDGYSVKSLIDRIETITPKLIITTNYGIFNDEIITFTPNLKDAIELS- 190
Query: 216 TFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIWWHEVLE-GESNICP-PEW 273
TF V + + +T LK ++ D+ T W+ E+ + E N P E+
Sbjct: 191 TFKPSNV----ITLFRNDITSESDLK-KVNDIPT-IPNTLSWYDEIKKFKEINQLPFYEY 244
Query: 274 VAAED--PLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWI 331
V E PL+++YTSG+TG K VV + Y++ ++ + + V + +GW+
Sbjct: 245 VPVESSHPLYIIYTSGTTGSAKAVVRSNGPYMV--GIKYQTLIQKGKIKVVFSHTSIGWV 302
Query: 332 TGHTYVVYAPLANAATSVMFEGTPYFPK--VDRYWSIINKYKVTQFYTAPTAIRALMAHY 389
+ H ++Y + T VM EG PK D W II + +V+ +T AIR L+
Sbjct: 303 SFHN-LLYGLFSVGYTLVMSEGGVTKPKHMEDDIWEIIERNEVSCAFTMAKAIRYLI-KV 360
Query: 390 NVEDGNL-TMPDLSSLRVLGSVGEPI 414
+ + NL + DLS+L+ + GEPI
Sbjct: 361 DPDCKNLHSKYDLSNLKEMVLGGEPI 386
Score = 72.1 bits (169), Expect = 5e-11
Identities = 52/179 (29%), Positives = 87/179 (48%), Gaps = 9/179 (5%)
Query: 508 KILNEDGVEIEGPGEGYLVFARPWP-GMMRTLLEDQDRFERVYFSKFPGYYCTGDGVRRD 566
++ ++DG E+ G LVF P P G T ++ ++F+++ F+KFPGYY GD +D
Sbjct: 404 RVFSDDGKELPLYEIGELVFKLPLPPGFTTTFYKNDEKFKQL-FTKFPGYYYPGDLGFKD 462
Query: 567 EDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALYCFVVL 626
E+ + R DD + +SG+ + ++E + P V E + + +VL
Sbjct: 463 ENNCYGVVSRSDDQIKISGNKVQLNKIETSILKHPLVLECCSIGINNPDCYNVPIGILVL 522
Query: 627 KEG------LQFDAD-LVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRK 678
K+ Q D + L + ++ + I FA I P LPKT+ GK R+I+ K
Sbjct: 523 KQQEENQSIRQIDLNKLQSEINTIISKDIENFAILRKILIVPQLPKTKVGKTQRQIISK 581
>UniRef50_A1S0M6 Cluster: AMP-dependent synthetase and ligase; n=1;
Thermofilum pendens Hrk 5|Rep: AMP-dependent synthetase
and ligase - Thermofilum pendens (strain Hrk 5)
Length = 588
Score = 146 bits (354), Expect = 2e-33
Identities = 173/637 (27%), Positives = 277/637 (43%), Gaps = 82/637 (12%)
Query: 20 SIQKYKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRV-FVKFMEEAE 78
++ +Y+ +Y S+ + FW+ A+ W KP + +G V++ E
Sbjct: 20 TLAEYRRVYRESVEDVYGFWSSYARLLLWR---KPWE------RVVEGEAPRVRWFAGGE 70
Query: 79 LNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGD 138
L+ N++ R+ K+A +E S D +TY L L + A L + G+ +GD
Sbjct: 71 LSPYENVVSRHRGTPVWRKVAVLYESESGDAEV-LTYEGLDALAGRIAGWLESVGVGRGD 129
Query: 139 RVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGE 198
V VY P E++ MLA R+GA VF GF LA+R++ ++++ T DG R
Sbjct: 130 WVTVYSPPNPESLAFMLAAMRVGAPFEPVFTGFGYYELAKRIARRGSRVVFTVDGYTRRG 189
Query: 199 RMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIWW 258
R + A+E++ + +V L R P +Y +E
Sbjct: 190 REVDTLGSVLRAVEESGA-----KPVLLVSERLGRKVPAAP------GVYTLDEALS--- 235
Query: 259 HEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHR 318
G + + + +PLF L+ S K + + AG+L+ AT R++
Sbjct: 236 SGAYSGSAVL------GSSEPLFGLH-SAYRDDFKPLSYPAAGFLVQVYATSRWI-GLKP 287
Query: 319 RDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTA 378
R+ + T GWITG +Y+V+ PL +T V+++G P + DR+ SI+ Y VT T
Sbjct: 288 RETLFNTVWPGWITGVSYLVFGPLMTGSTVVLYDGAPDWRGWDRWISIVESYGVTLLLTT 347
Query: 379 PTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFW 438
A+R LM+ E D SL+ + EP++ W W Y+ +G + +VD+
Sbjct: 348 SGALR-LMSRQPAE--LFRSHDYDSLKAVLVTAEPLDAETWGWAYSVLGTLKRPLVDS-- 402
Query: 439 QTETGGHVITGLPGATPMKPGAAEKKHPVYYSSMDTFRPKQGWDRTVMIVHLPNKSNRTR 498
V + L GA P+ + S + TF G + H+ T
Sbjct: 403 -------VPSELSGAIPVLDLYIQ-------SEVGTF--LVGNLPSYTFTHI---VPGTC 443
Query: 499 GFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKF-PGYY 557
G P G ++L EDG LV +PWP + D ++ K+ G+Y
Sbjct: 444 GPPMPGFHVEVL-EDG---------RLVVRKPWPAIPVEAPGD-------FWEKWREGFY 486
Query: 558 CTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKG 617
TGD R DGY+ + GR D ++ VSG+ +S +E V+A P V V +P +K
Sbjct: 487 DTGDAARYSVDGYIEVLGRRDGVMKVSGYRVSPGAIERVVAGVPGVRGVRVYARPDPLKF 546
Query: 618 EALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAP 654
E VV EG D + V+ VR+K+G P
Sbjct: 547 EVP---VVSVEG-SADPEAVRK---AVREKLGPILEP 576
>UniRef50_Q01NM8 Cluster: AMP-dependent synthetase and ligase; n=1;
Solibacter usitatus Ellin6076|Rep: AMP-dependent
synthetase and ligase - Solibacter usitatus (strain
Ellin6076)
Length = 610
Score = 146 bits (353), Expect = 2e-33
Identities = 81/197 (41%), Positives = 118/197 (59%), Gaps = 5/197 (2%)
Query: 499 GFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYC 558
G P G+ ++++E GV + G +GYLV RP P M R + D +R+ Y+SKFPG +
Sbjct: 416 GGPAPGMSTEVVDESGVPVRGR-KGYLVCTRPAPSMTRGIWGDPERYIETYWSKFPGMWY 474
Query: 559 TGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGE 618
GD DEDG+ ++ GR D+ +NV+G + AEVE + P V+EAAV+ P E+KGE
Sbjct: 475 HGDWASVDEDGHWFLHGRADESMNVAGRKVGPAEVEEAMMQHPDVAEAAVIGVPDELKGE 534
Query: 619 ALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRK 678
+ F V K G DA V V + +G P I LPKT+SGKI+RR++R+
Sbjct: 535 TIVGFAVAKAGTVLDAAAV---VRTVVEVLGPTFRPREIVVVTELPKTQSGKIVRRLIRQ 591
Query: 679 IAVGDHEVGDISTLADP 695
+G+ E+GD+ST+A+P
Sbjct: 592 KYLGE-ELGDLSTVANP 607
Score = 136 bits (329), Expect = 2e-30
Identities = 73/203 (35%), Positives = 109/203 (53%), Gaps = 8/203 (3%)
Query: 258 WHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYH 317
W E L + E + AE F+LYTSG+TGKPKG VHT AG L FD+
Sbjct: 220 WQEFLASQPAEFATESLEAEARAFILYTSGTTGKPKGTVHTHAGSLAQMGKEIWLGFDHR 279
Query: 318 RRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYT 377
+ ++ +D+GW+ G + + T +++G P +P R W I+++++T F
Sbjct: 280 EGERFFWLSDIGWMMG-PWTILGNHLFGGTIFLYDGAPDYPGPMRLWETIDRHRITTFGV 338
Query: 378 APTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTF 437
+PTAIR L G L P + SLR+LGS GEP + A+WLW++ R+G+ RC I++
Sbjct: 339 SPTAIRVL----RKSPGEL--PAMESLRLLGSTGEPWDDASWLWFFERVGRRRCPIINIS 392
Query: 438 WQTETGGHVITGLPGATPMKPGA 460
TE G + LP +KP +
Sbjct: 393 GGTEIVGSFLFPLP-IQALKPSS 414
Score = 81.8 bits (193), Expect = 6e-14
Identities = 56/170 (32%), Positives = 86/170 (50%), Gaps = 12/170 (7%)
Query: 25 KEMYERSLTESELFWTEVAQEF--QWHVAPKPGGFMKYNFDITKGRVFVKFMEEAELNVC 82
+E S E FW E+ +E +W + K D++ G + ++ LN+
Sbjct: 32 EEFLRFSRENPERFWGEMMREMRVEWFTP-----YSK-ELDLSGGPEWARWFIGGRLNIA 85
Query: 83 YNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAV 142
+N LDR + D A WEG S T +T+R+L + + ANGL A G+ GDRVA+
Sbjct: 86 HNCLDRWADS---DCAACIWEGESGAGGT-LTFRELREQANRTANGLRALGLEAGDRVAL 141
Query: 143 YMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTAD 192
+PM E + + C + G +FAGF + A+A RL D+ A +L TA+
Sbjct: 142 CLPMTPEILPILYGCFKAGLTVVPIFAGFGTGAIATRLIDSGACVLFTAE 191
>UniRef50_Q55GU6 Cluster: Putative acetyl-CoA synthetase; n=3;
Dictyostelium discoideum|Rep: Putative acetyl-CoA
synthetase - Dictyostelium discoideum AX4
Length = 684
Score = 144 bits (349), Expect = 7e-33
Identities = 123/430 (28%), Positives = 195/430 (45%), Gaps = 29/430 (6%)
Query: 24 YKEMYERSLTESELFWTEVAQEF-QWHVAPKPGGFMKYNFDITKGRVFVKFMEEAELNVC 82
Y+ Y S FW EVA++F W Y+ + ++ + + ELN C
Sbjct: 10 YENDYSYSQINPISFWDEVAKKFVHWDKI--------YDKVYSGDEIYPDWFQGGELNTC 61
Query: 83 YNLLDRNVKNGFG-DKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVA 141
YN+LD+ VKN DK A +E ++TY +L + VC+F+ LL I K D V
Sbjct: 62 YNVLDKQVKNPLKRDKDALIYECLYLKKTVKLTYYQLYEKVCEFSRVLLNINISKNDNVL 121
Query: 142 VYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGERMY 201
+YM LE +I ML+CARIGA TV+F G+ +L +R+ L++T++ + +
Sbjct: 122 IYMANTLEPLIAMLSCARIGATFTVLFEGYPVKSLIDRIETITPTLIITSNYGILNDELI 181
Query: 202 VYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIWWHEV 261
+ +AI+++ H ++ H K+ I + D W E+
Sbjct: 182 TFTPNLKEAIQQSAFKPNH------IITHFRNDYEDIEFKNIIGTMTIIPNTLD-WDKEI 234
Query: 262 LEGESNICPP--EWVAAED--PLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYH 317
+ + N P E+V E PL + +TSG+TG K VV L+ +
Sbjct: 235 QKIKYNNQSPFYEYVPVESSHPLSIHFTSGTTGNAKAVVRGNGSNLVGLVYNWYSSMSSK 294
Query: 318 RRD--VYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFP-KVDRY-WSIINKYKVT 373
+ D VY+ + +GWIT H ++ LA T VMFEG P + Y W+ I K+K+
Sbjct: 295 KYDDSVYFSHSSIGWITFHMGLI-GSLALGNTFVMFEGGITKPIHYEHYLWATIEKHKIN 353
Query: 374 QFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSI 433
F T IR L+ + + D SSL + GE I + + +++ +C
Sbjct: 354 TFLTLAKTIRYLIKNDPGATNINSKYDSSSLLSIWIAGEVIEQSIPEYIESKL---KCCS 410
Query: 434 VDTFWQTETG 443
+ + QTE G
Sbjct: 411 GNVYGQTEGG 420
Score = 65.3 bits (152), Expect = 5e-09
Identities = 40/140 (28%), Positives = 61/140 (43%)
Query: 492 NKSNRTRGFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFS 551
NK T P ++P I +EDG+E+ G +VF P P T + + F+
Sbjct: 432 NKQYNTLINPTPFLKPSIFSEDGIELPDNQVGEIVFKLPMPPSFATTFYKNELLYKKIFN 491
Query: 552 KFPGYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPK 611
KFPGYY +G + E Y I R DD + + G + ++E + P V E +
Sbjct: 492 KFPGYYNSGVITFKKEIDYYGIVSRADDQIKIGGFKVDLNQIETSILKHPLVLECCSIAI 551
Query: 612 PHEVKGEALYCFVVLKEGLQ 631
H+ +VLK+ Q
Sbjct: 552 YHQDLKNVPIGLLVLKQQQQ 571
>UniRef50_Q75JX6 Cluster: Similar to Vibrio cholerae. PrpE protein;
n=21; Dictyostelium discoideum|Rep: Similar to Vibrio
cholerae. PrpE protein - Dictyostelium discoideum (Slime
mold)
Length = 658
Score = 142 bits (345), Expect = 2e-32
Identities = 117/414 (28%), Positives = 198/414 (47%), Gaps = 26/414 (6%)
Query: 38 FWTEVAQEF-QWHVAPKPGGFMKYNFDITKGRVFVKFMEEAELNVCYNLLDRNVKN-GFG 95
FW EVA+++ W Y+ + ++ + + ELN CYN+LD++VKN
Sbjct: 24 FWDEVAKKYAHWD--------KMYDKVYSSDGMYPDWFKGGELNTCYNVLDKHVKNPSKR 75
Query: 96 DKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICML 155
D+ A +E ++TY +L + VC+F+ LL I K D V +YM LE +I +L
Sbjct: 76 DQDALIYECPFIKKTIKLTYFQLYEKVCEFSRVLLNLNISKNDNVLIYMANTLEPIIALL 135
Query: 156 ACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGERMYVYKRTCDDAIEKAR 215
+CARIGA V++ G+ +L +R+ KL++T++ + + + DAI+ +
Sbjct: 136 SCARIGATFIVLYDGYPVKSLIDRIDTFTPKLIITSNCGILNDEIITFTSDLKDAIQLS- 194
Query: 216 TFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIWWHEVLEGESNICPP--EW 273
TF + V + N+ D + I + N T W E+ + + N P E+
Sbjct: 195 TFKPNHV-ITHFRNNEDIEFNDSIIIGTIPIIPN----TLDWDKEIQKIKDNNQKPFYEY 249
Query: 274 VAAED--PLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWI 331
V E PL + + SG++G K +V + G ++ A ++ VY + +GW
Sbjct: 250 VPVESSHPLSIYFPSGTSGNYKAIVRSNGGSIVGLAYSWFSCISKKDETVYLSHSSIGWA 309
Query: 332 TGHTYVVYAPLANAATSVMFEGTPYFP-KVDRY-WSIINKYKVTQFYTAPTAIRALMAHY 389
T H ++ L T VMFEG P + Y W+ I K+K+ F T+P IR L+ +
Sbjct: 310 TFH-LGLFGSLGLGNTMVMFEGDIMKPIHYEHYLWATIEKHKINTFLTSPKTIRYLIKND 368
Query: 390 NVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTETG 443
+ DLSSL + + GE I + + +++ +C + + QTE+G
Sbjct: 369 PDASKIKSKYDLSSLVSIWTSGEVIEQSIPEYIESKL---KCRSSNLYGQTESG 419
Score = 78.6 bits (185), Expect = 5e-13
Identities = 54/197 (27%), Positives = 88/197 (44%), Gaps = 11/197 (5%)
Query: 493 KSNRTRGFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSK 552
K N T P ++P I +EDG+E+ G + F P P T + + F+K
Sbjct: 432 KQNNTLINPTPFLKPSIFSEDGIELPENQVGEVAFKLPLPPSFATTFYKNELLYKKMFNK 491
Query: 553 FPGYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKP 612
FPGYY +GD ++E+ Y I R DD +N G + E+E + P V E +
Sbjct: 492 FPGYYNSGDLGFKNENDYYGIVSRADDQINSRGFYVLLNEIETSILKHPLVLECCSIGIH 551
Query: 613 HEVKGEALYCFVVLKEGLQFDA-----------DLVKTLTLLVRQKIGAFAAPDTIQNAP 661
H+ +VL + ++ DL + +++ + ++ I P
Sbjct: 552 HQDLANVPIGLLVLNQQQPDNSSLSSSSSSSLIDLKNQINEIIKNDMDYYSELSKIIIVP 611
Query: 662 GLPKTRSGKIMRRILRK 678
LPKT++GKI R+I+ K
Sbjct: 612 QLPKTKTGKIPRQIISK 628
>UniRef50_A6C4K4 Cluster: Acetate--CoA ligase; n=1; Planctomyces
maris DSM 8797|Rep: Acetate--CoA ligase - Planctomyces
maris DSM 8797
Length = 679
Score = 136 bits (329), Expect = 2e-30
Identities = 154/626 (24%), Positives = 261/626 (41%), Gaps = 87/626 (13%)
Query: 59 KYNFDITKGRVFVKFMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKL 118
K D+ G ++++ A LN+ + L ++IA ++ S D+ +++YR+L
Sbjct: 130 KQIMDLHAGVEQIEWLRGASLNIVESCLREK-----SEQIAILFQ-RSTDEVQQLSYREL 183
Query: 119 LDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAE 178
L + ANGL GI G+R+AV +PM E+V L G V + FS++ +
Sbjct: 184 RALTARVANGLTEAGIEPGERIAVMLPMTPESVAIFLGIIAAGCVVVTIADSFSAEEMQV 243
Query: 179 RLSDAKAKLLVTADGAWR-GERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPG 237
RL +L+ D R G ++ +Y + + L + P
Sbjct: 244 RLKITAPRLIFIQDVITRNGRQLPLYAK----------------------LESLSEL-PA 280
Query: 238 GSLKSEIKDLYNWNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVH 297
L + E +W + C P +D +L++SG+TG PKG+
Sbjct: 281 VVLPESASHTVSLREHDQLWSDFLSASLELNCVPR--KPQDETTILFSSGTTGNPKGIPW 338
Query: 298 TTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYF 357
+ A + + D H D+ ++GW+ G ++VYA L N AT + +
Sbjct: 339 DQTTPIKSAGDGYLH-HDIHAGDIVCWPTNLGWMMG-PWLVYAALINDATIALSDAV--- 393
Query: 358 PKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPA 417
P R+ + VT P+ + A + ++ + D S ++V S GE NP
Sbjct: 394 PTSRRFCEFVQNAGVTMLGLVPSIVSA----WRSQETTAGL-DWSHIKVFSSTGECSNPD 448
Query: 418 AWLWYYTRIGKERCSIVDTFWQTETGGHVITGLPGATPMKPGAAEKKHPVYYSSMDTFRP 477
LW +R G +++ TETGG ITG T +KPG P +S P
Sbjct: 449 DMLWLMSRAGYR--PVIEYCGGTETGGGYITG----TVLKPGV-----PGLFSC-----P 492
Query: 478 KQGWDRTVMIVHLPNKSNRTRGF--PFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMM 535
G++ ++ +N F P G+ +++N D E+ Y P P
Sbjct: 493 ALGFEWLLLNETGKETANGEVFFVPPVIGLSTRLINRDHHEV------YYADIAPGPD-G 545
Query: 536 RTLLEDQDRFERVYFSKFPGYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEG 595
+ L D+ E + PG GY GR+DD +N+ G +S+ ++E
Sbjct: 546 QVLRRHGDQIEAL-----PG-------------GYFRAHGRVDDAMNLGGIKVSSVQIEE 587
Query: 596 VLASDPRVSEAAVVPKPHEVKGEA-LYCFVVLKEGLQF-DADLVKTLTLLVRQKIGAFAA 653
+L V E A + P G L F+V++EG F A++ + + ++R ++
Sbjct: 588 LLTQTSGVREVAAIAVPPSGGGPGQLVIFMVMQEGAAFVAAEIQQQMQQIIRSQLNPLFK 647
Query: 654 PDTIQNAPGLPKTRSGKIMRRILRKI 679
++ LP+T S K+MRR LR +
Sbjct: 648 IHAVREIEQLPRTASNKVMRRKLRDL 673
>UniRef50_Q5UWB7 Cluster: Acyl-coenzyme A synthetases; n=2;
Halobacteriaceae|Rep: Acyl-coenzyme A synthetases -
Haloarcula marismortui (Halobacterium marismortui)
Length = 616
Score = 134 bits (325), Expect = 6e-30
Identities = 113/390 (28%), Positives = 186/390 (47%), Gaps = 50/390 (12%)
Query: 78 ELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKG 137
+LN+ + + DR+ + ++A + G + +++T+ +L D QFAN L G+ +G
Sbjct: 89 DLNIGHEVADRHATDR--GQVALYQVGTD-GELSKMTFWELADRSSQFANVLDDLGVAQG 145
Query: 138 DRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRG 197
DRV YMP I E + ++ + GAV V F D ++ RL D AK++VT
Sbjct: 146 DRVFSYMPRIPEHYVALVGTLKHGAVWGSVNERFGPDGISYRLDDCDAKVVVTTTNN--- 202
Query: 198 ERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIW 257
+ T +DA++ A V H+ V GG ++ D+
Sbjct: 203 ------RDTVEDALDDAPA-----------VEHVITVDRGGGAPAD-----------DVV 234
Query: 258 WHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYH 317
++ L+G S + ED + YTSG+TG KGV+H ++ AAT ++ D
Sbjct: 235 FNTALDGASTAYEVAETSGEDDALLYYTSGTTGLAKGVLHKQR-WIAGVAATQKHAVDLQ 293
Query: 318 RRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYT 377
D+YW T D+GW+TG + A A+ +EG F D + +++++Y ++ ++
Sbjct: 294 DGDLYWSTGDLGWLTGAINTLGAWFWGASL-FTYEGE--F-DTDEWAALLDEYPISVLFS 349
Query: 378 APTAIRALMAHYNV-EDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDT 436
PTA R L + +V D NL LR S+GEP++ W +G +I+DT
Sbjct: 350 VPTAYRMLRENEDVLADVNL------DLRHALSIGEPLSAGVVEWGEDELG---VTILDT 400
Query: 437 FWQTETGGHVITGLPGATPMKPGAAEKKHP 466
+ QTETG +I P ++PG+ K P
Sbjct: 401 YGQTETGNMIINNYP-TMELRPGSMGKPLP 429
Score = 105 bits (252), Expect = 4e-21
Identities = 63/190 (33%), Positives = 94/190 (49%), Gaps = 2/190 (1%)
Query: 499 GFPFFGVEPKILNEDGVEIEGPGE-GYLVFARPWPGMMRTLLEDQDRFERVYFSKFPG-Y 556
G P G+E I++ E+ PGE G + +P + +R + G +
Sbjct: 425 GKPLPGIEADIVDPQSGEVLEPGETGEIAQRGDYPCFFAEFWNKPKKTQRAFIDGPDGKW 484
Query: 557 YCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVK 616
Y +GD +DEDGY W GR DD++ SG+ + EVE L V+EAAVVPKPHE +
Sbjct: 485 YLSGDLAHKDEDGYFWFEGRADDVILSSGYRIGPFEVESSLGEHEAVAEAAVVPKPHEAR 544
Query: 617 GEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRIL 676
G + +VV + + L + + V++++ A P I+ LPKT +GKI R L
Sbjct: 545 GNIVKAYVVPSDDAEPSDPLKEDIQSYVKEELSAHEYPREIEFREELPKTVTGKIRRTEL 604
Query: 677 RKIAVGDHEV 686
A + EV
Sbjct: 605 HDDAEAEAEV 614
>UniRef50_A4A7V6 Cluster: Acetyl-coenzyme A synthetase/GroES-like
domain; n=4; Bacteria|Rep: Acetyl-coenzyme A
synthetase/GroES-like domain - Congregibacter litoralis
KT71
Length = 1809
Score = 133 bits (322), Expect = 1e-29
Identities = 89/278 (32%), Positives = 141/278 (50%), Gaps = 13/278 (4%)
Query: 173 SDALAERLSDAKAKLLVTADGAWRGERMYVYKR-TCDDAIEKARTFFKHRVDMCMVVNHL 231
+D AER ++ + + G + V R T D + ++R + H + L
Sbjct: 303 ADLAAERSAELRTTVARELAGVEHTVKQVVVVRYTGQDIVRQSRDRWSHELVSEATDRVL 362
Query: 232 DRVTPGGSLKSEIKDLYNWNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGK 291
+ G + + I++L + D+ H+ L P V A+ PLF++YTSGSTGK
Sbjct: 363 AKAAEEGFIAANIEELLKLGDR-DL--HKALCASHAPVP---VDADWPLFIIYTSGSTGK 416
Query: 292 PKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMF 351
PKGVVHT G+L A T R VF+ D + D GWITG Y++ APL +++
Sbjct: 417 PKGVVHTHGGWLAGIAHTMRMVFNAEGDDRIYVVGDPGWITGQAYLIAAPLCLGIGTIIA 476
Query: 352 EGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAH-YNVEDGNLTMPDLSSLRVLGSV 410
EG+P FP R+ SII ++K + F T ++A+M +VED ++ D+S ++V
Sbjct: 477 EGSPLFPHAGRFSSIIERHKASIFKAGSTFLKAVMTDPASVED--MSTYDMSGVKVATFC 534
Query: 411 GEPINPAAWLWYYTRIGKERCSIVDTFWQTETGGHVIT 448
EP++PA + RI ++++W TE GG V +
Sbjct: 535 AEPVSPAVQQFGMDRICDH---YINSYWATEHGGMVFS 569
Score = 123 bits (297), Expect = 1e-26
Identities = 81/203 (39%), Positives = 105/203 (51%), Gaps = 22/203 (10%)
Query: 520 PGE-GYLVFARPWPGMMRTLLEDQD------------RFERVYFSKFPG--YYCTGDGVR 564
PGE G LV +P+P + RT+ D D RF VYF+++ Y GD R
Sbjct: 614 PGEKGELVITQPYPYLARTIWGDADALGTDEWQGDIKRFAEVYFNRWSDGLAYTQGDYAR 673
Query: 565 RDEDGYLWITGRIDDMLNVSGHLMSTAEVEGV------LASDPRVSEAAVVPKPHEVKGE 618
EDG + GR DD++NVSGH + T E+EG L +D V VV PH+ KGE
Sbjct: 674 SHEDGAFTLHGRSDDVINVSGHRIGTEEIEGAVLRDKTLRTDSPVGNVVVVGAPHDEKGE 733
Query: 619 ALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRK 678
F++ G + D L LVR + GA A P P P+TRSGK MRR LR
Sbjct: 734 TPVAFLIAAPGSRLGDDDFSRLQGLVRSEKGATAVPSDFLVIPAFPETRSGKYMRRTLRA 793
Query: 679 IAVGDHEVGDISTLADPGVVEEL 701
I + D +GD+STL +P VV E+
Sbjct: 794 ILL-DEPLGDLSTLRNPEVVPEI 815
Score = 90.6 bits (215), Expect = 1e-16
Identities = 51/151 (33%), Positives = 81/151 (53%), Gaps = 11/151 (7%)
Query: 70 FVKFMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGN-----------SPDDYTRITYRKL 118
F ++ A N C+N +DR+V G GD A +EG+ P +++R+L
Sbjct: 90 FYRWYAGALTNACFNEVDRHVLAGRGDATAIVFEGDRWDPSRNDGKGGPVQEITVSFRQL 149
Query: 119 LDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAE 178
L A L + G+++GDR+A +P ILE + A R+G ++T VF GFS+ L++
Sbjct: 150 LAETVLRAEVLSSLGLKRGDRIAFNLPNILEQIFYTQAAKRLGIIYTPVFGGFSAKTLSD 209
Query: 179 RLSDAKAKLLVTADGAWRGERMYVYKRTCDD 209
R+ DA A +++TADG +R + YK D
Sbjct: 210 RIYDAGATVVITADGGYRNAEVVSYKEAYTD 240
>UniRef50_Q4J776 Cluster: Acetyl-coenzyme A synthetase; n=2;
Sulfolobus|Rep: Acetyl-coenzyme A synthetase -
Sulfolobus acidocaldarius
Length = 561
Score = 133 bits (321), Expect = 2e-29
Identities = 74/213 (34%), Positives = 120/213 (56%), Gaps = 5/213 (2%)
Query: 488 VHLPNKSNRTRGFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFER 547
V +P K + G P GV+ +++E+G + +G L +P M + + D++R++
Sbjct: 353 VSMPIKIG-SMGKPLPGVKALVVDENGNPLPPNTKGILALDPDFPAMAKGIWNDEERWKN 411
Query: 548 VYFSKFPGYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAA 607
+ + GYY TGD DEDGY W GR DD++ VSG+ +S E+E V+ + P V+E+A
Sbjct: 412 SFKN---GYYLTGDMGYIDEDGYFWYLGRADDIIKVSGYRISPVEIESVIMTHPAVAESA 468
Query: 608 VVPKPHEVKGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTR 667
V+ ++G + ++VLK+ +L + VR K+GA P ++ LP T
Sbjct: 469 VIGVEDPIRGFRIKAYIVLKKDYSPSDELKNEIINHVRVKLGAHVVPREVEIVKELPHTL 528
Query: 668 SGKIMRRILRKIAVGDHEVGDISTLADPGVVEE 700
SGK MRR+LR I G ++GD+STL +P V++
Sbjct: 529 SGKTMRRVLRAIESGS-QLGDVSTLENPETVKK 560
Score = 95.1 bits (226), Expect = 6e-18
Identities = 73/209 (34%), Positives = 106/209 (50%), Gaps = 14/209 (6%)
Query: 260 EVLEGESNICPPEWV--AAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYH 317
E + E N+ +V + DP +LYTSG+TG+PKG+ H + + + + +Y FD H
Sbjct: 171 EGIVNEQNVHNTSYVERSINDPTLILYTSGTTGRPKGIWH-SQDIMTFYYFSGKYHFDMH 229
Query: 318 RRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYT 377
+D +W T D W+ G V A L N+ V +EG F + ++S I + KVT T
Sbjct: 230 AQDKFWHTGDPAWVAGFAGVWTAWL-NSIPIVSYEGK--F-DAESWYSNIERVKVTLMST 285
Query: 378 APTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTF 437
APTAIR L+ VE DLSS+R + + GE ++P W G I D +
Sbjct: 286 APTAIR-LLKKEGVELARKF--DLSSIRFIHAGGEYVDPDIIRWSMEVFG---VPIHDGY 339
Query: 438 WQTETGGHVITGLPGATPMKPGAAEKKHP 466
QTET +VI + P+K G+ K P
Sbjct: 340 GQTETATYVIANYV-SMPIKIGSMGKPLP 367
Score = 42.3 bits (95), Expect = 0.043
Identities = 32/129 (24%), Positives = 54/129 (41%), Gaps = 5/129 (3%)
Query: 61 NFDITKGRVFVKFMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLD 120
NF+ R + F+ + NV ++D N DK W D T+ L
Sbjct: 25 NFNWDNARKTLNFVGKG--NVSKLVMDLNADGK--DKSGLIWISEK-GDIKSYTFHDLEV 79
Query: 121 LVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERL 180
F L G++ GDRV V + +LA IGAV +++ F +A+ R+
Sbjct: 80 KASSFGAVLKDSGVKPGDRVVVMSKRVPSLYFSLLAIGMIGAVIVPIYSTFGEEAIRYRV 139
Query: 181 SDAKAKLLV 189
++ +K+ +
Sbjct: 140 ENSGSKVAI 148
>UniRef50_Q39T59 Cluster: AMP-dependent synthetase and ligase; n=1;
Geobacter metallireducens GS-15|Rep: AMP-dependent
synthetase and ligase - Geobacter metallireducens
(strain GS-15 / ATCC 53774 / DSM 7210)
Length = 539
Score = 130 bits (315), Expect = 1e-28
Identities = 78/188 (41%), Positives = 106/188 (56%), Gaps = 11/188 (5%)
Query: 276 AEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHT 335
A+ P + YTSGSTGKPKGV+H M + T + V DVYWCTAD GW+TG +
Sbjct: 173 ADAPSVLHYTSGSTGKPKGVLHRHGAVTMINS-TAQLVLGLREDDVYWCTADQGWVTGTS 231
Query: 336 YVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGN 395
Y + P + T V F G Y ++++ I+ + +V+ +YTAPTA+R LM E
Sbjct: 232 YGIIGPWSMGVTQVHF-GGGY--AAEQWFEILEREEVSVWYTAPTALRMLMRE---EPLL 285
Query: 396 LTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTETGGHVITGLPGATP 455
DL LR + SVGEP+NP W + KE + DT++QTETG +I PG P
Sbjct: 286 FARFDLGMLRHICSVGEPLNPEVIHWARRVLAKE---VYDTWFQTETGAIMIANRPG-IP 341
Query: 456 MKPGAAEK 463
+KPG+ K
Sbjct: 342 VKPGSMGK 349
Score = 126 bits (303), Expect = 3e-27
Identities = 74/198 (37%), Positives = 105/198 (53%), Gaps = 8/198 (4%)
Query: 499 GFPFFGVEPKILNEDGVEIEGPGE-GYLVFARPWPGMMRTLLEDQDRFERVYFSKFP-GY 556
G P G+E +++ +G E+ G G+ G L W M + L + Y SKF G+
Sbjct: 348 GKPVDGIEAVVISTEG-ELLGSGQQGDLCLKPGWASMFSSYLNNAG----AYASKFRNGF 402
Query: 557 YCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVK 616
YCTGD RD DGY W GR DD++N +GHL+S E+E L V+EA V+ P E+
Sbjct: 403 YCTGDVAYRDTDGYFWFVGRSDDVINTAGHLISPFEIESALIEVHEVAEAGVIGAPDELL 462
Query: 617 GEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRIL 676
E + FV L G +L + L + K+ + A P I +PK +SGKIMRR L
Sbjct: 463 YEKVVAFVSLHLGYALTDELQLKIRLHLANKLSSVATPHEIHCLERIPKNKSGKIMRRYL 522
Query: 677 RKIAVGDHEVGDISTLAD 694
+ +G + GDIST+ +
Sbjct: 523 KATYLG-QDAGDISTMEE 539
Score = 57.6 bits (133), Expect = 1e-06
Identities = 36/119 (30%), Positives = 60/119 (50%), Gaps = 5/119 (4%)
Query: 74 MEEAELNVCYNLLDRNVKNGFGDKIAFFW--EGNSPDDYTRITYRKLLDLVCQFANGLLA 131
+E + N+ R + G GD++A W G DYT + +L L +FAN L +
Sbjct: 3 IENGQYNIGDICTSRQCRLGRGDRVAMRWLTPGMERRDYT---FNELDGLSGRFANVLAS 59
Query: 132 KGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVT 190
G+ G+ Y+P E + L ++ AV +F+ F +AL +RL+DA+A ++T
Sbjct: 60 LGVGAGEVFFTYLPKQPEQFVAFLGALKLTAVAGTLFSNFGEEALLDRLADARACGIIT 118
>UniRef50_A4TUE0 Cluster: Acyl-coenzyme A synthetases/AMP-(Fatty)
acid ligases; n=5; Proteobacteria|Rep: Acyl-coenzyme A
synthetases/AMP-(Fatty) acid ligases - Magnetospirillum
gryphiswaldense
Length = 588
Score = 129 bits (312), Expect = 2e-28
Identities = 75/176 (42%), Positives = 99/176 (56%), Gaps = 10/176 (5%)
Query: 277 EDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTY 336
E P F+ +TSG+TG PKGV+H+ + ++ A T R VF DV+WCTAD GWIT Y
Sbjct: 209 ETPAFLHFTSGTTGTPKGVLHSHSA-VVAEALTARQVFGLVPDDVFWCTADPGWITNTAY 267
Query: 337 VVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNL 396
+ APLAN V+ + + P+ R++ I+ KVT +YT PT IR +M Y
Sbjct: 268 ALIAPLANGC-QVVVDEDDFDPR--RWYGILKDEKVTVWYTTPTNIR-MMMRYGAALARA 323
Query: 397 TMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTETGGHVITGLPG 452
+SLRV SVGEP+NP A W +G +DT+WQTETG I PG
Sbjct: 324 YKE--NSLRVAASVGEPLNPEAVAWGEKALG---VPFLDTWWQTETGAIAIANCPG 374
Score = 105 bits (252), Expect = 4e-21
Identities = 68/206 (33%), Positives = 94/206 (45%), Gaps = 8/206 (3%)
Query: 485 VMIVHLPNKSNR-TRGFPFFGVEPKILNEDGVEIEGPGE----GYLVFARPWPGMMRTLL 539
+ I + P K+ + G P GVE +++ D + G G L P M +
Sbjct: 367 IAIANCPGKAKAGSMGMPLPGVEAAVISRDLSSVTPVGRADEVGELALRADLPSMFTAYM 426
Query: 540 EDQDRFERVYFSKFPGYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLAS 599
+ ++ S G+Y TGD VRRD DG W GR DDM+ + H + EVE L
Sbjct: 427 GEGANYD---LSFIDGWYLTGDLVRRDADGCFWFVGRADDMIKSASHTIGPFEVECGLMD 483
Query: 600 DPRVSEAAVVPKPHEVKGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQN 659
P V+E VV KP + E F+ L G + L L RQ +G AP I
Sbjct: 484 HPAVAEIGVVGKPDLLLREVPVAFISLNPGFEAGEALRVELLTFARQCLGGTLAPREIHF 543
Query: 660 APGLPKTRSGKIMRRILRKIAVGDHE 685
+PKT +GKI+RR L+ AV + E
Sbjct: 544 VDSMPKTTTGKILRRALKAKAVAEPE 569
Score = 70.9 bits (166), Expect = 1e-10
Identities = 39/120 (32%), Positives = 64/120 (53%), Gaps = 1/120 (0%)
Query: 77 AELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRK 136
A +N+ Y +DR+V G GD+ A G + R++Y +L DL + A L A G+
Sbjct: 39 AGMNIAYAAVDRHVAAGRGDRPAILSLGRRYEK-RRLSYAQLADLSARLAAVLAAHGVGA 97
Query: 137 GDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWR 196
GD+VAV +E + C ++GAV+ +F+ F L RL ++AK+L+ + +R
Sbjct: 98 GDKVAVLTGRSVELYVAAFGCWKVGAVYCPLFSAFGPGPLKSRLELSRAKVLIATEELYR 157
>UniRef50_Q72J94 Cluster: Acetyl-coenzyme A synthetase; n=2; Thermus
thermophilus|Rep: Acetyl-coenzyme A synthetase - Thermus
thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Length = 845
Score = 129 bits (311), Expect = 3e-28
Identities = 76/195 (38%), Positives = 101/195 (51%), Gaps = 13/195 (6%)
Query: 265 ESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWC 324
E+ PE V A PLF+L TSGSTGKPKGVVH GY++ A R+VFD +V+
Sbjct: 465 EARPAEPEPVPAAHPLFLLPTSGSTGKPKGVVHGHGGYMVGVAWALRHVFDLKPGEVFHT 524
Query: 325 TADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRA 384
TAD+ WI GH++ +YAPL TS++ E P P ++ + V T+P +R
Sbjct: 525 TADLFWIVGHSFGLYAPLLLGGTSLLVEDRPDHPSPGAFYERLAHLGVDVLLTSPAVLRT 584
Query: 385 LMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTETGG 444
L H + LR+ SVGE ++P W W TR + VD +WQTE G
Sbjct: 585 LRRHGEARP--------TGLRLAASVGEVLSPEIWRW--TR--EHLAWPVDNWWQTELGA 632
Query: 445 HVITGLPGATPMKPG 459
+ P A P KPG
Sbjct: 633 PAL-ATPPALPAKPG 646
Score = 89.0 bits (211), Expect = 4e-16
Identities = 69/209 (33%), Positives = 104/209 (49%), Gaps = 16/209 (7%)
Query: 490 LPNKSNRTRGFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVY 549
LP K G P GVE ++++E+G + +G+LV P M L + +
Sbjct: 641 LPAKPGHV-GLPLPGVEARVVDEEGRPLPPGSKGHLVLGATGPAHMVDLQGGRSPWRG-- 697
Query: 550 FSKFPGYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVV 609
G Y TGD DE+GY I GR ++++ V + AEVE VL + P+V+EAA V
Sbjct: 698 -----GLYWTGDLAEMDEEGYFRILGRTEEVIKVGEARIGPAEVEAVLLTHPQVAEAAAV 752
Query: 610 PKPHEVKGEALYCFVVLKEGLQFDAD----LVKTLTLLVRQKIGAFAAPDTIQNAPGLPK 665
P E GE + FVV + +F + L + L + + +G P + LP+
Sbjct: 753 GVPGET-GEEIAVFVV-PQAREFPEELKPLLAEKLKAHILRHLGP-VPPPRVFFRERLPR 809
Query: 666 TRSGKIMRRILRKIAVGDHEVGDISTLAD 694
TRSGKI+RR+L+ +G + GD S L +
Sbjct: 810 TRSGKILRRLLKAELLG-LDPGDTSGLEE 837
Score = 80.2 bits (189), Expect = 2e-13
Identities = 57/176 (32%), Positives = 84/176 (47%), Gaps = 13/176 (7%)
Query: 28 YERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRVFVKFMEEAELNVCYNLLD 87
+ SL + E FW A+ F W P F + + G + NV N LD
Sbjct: 271 HRASLEDPEAFWEGFARGFAWE-RPWKAVFRREDRTWFAGGL---------TNVALNALD 320
Query: 88 RNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMI 147
R++ +G + TY+++ +L + A G+ +GDRVA+Y+P
Sbjct: 321 RHLPEKAQQVALLTLDGEGR--LGKWTYKEVRELSSRLAGLFRTLGVGRGDRVALYLPTG 378
Query: 148 LEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADG-AWRGERMYV 202
LEA + LACARIGAVH + G +AL RL D + +LLV AD +RG+ + V
Sbjct: 379 LEAALAALACARIGAVHAALPLGLGPEALRRRLEDLRPRLLVAADAYFYRGQPVRV 434
>UniRef50_O30042 Cluster: Acetyl-CoA synthetase; n=1; Archaeoglobus
fulgidus|Rep: Acetyl-CoA synthetase - Archaeoglobus
fulgidus
Length = 662
Score = 128 bits (310), Expect = 4e-28
Identities = 123/455 (27%), Positives = 207/455 (45%), Gaps = 46/455 (10%)
Query: 7 KPTDHVIKKSYLPSIQKYKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITK 66
K D V+ ++ +++ YK +++ S+ E FW V + F+ + Y + +
Sbjct: 30 KGLDFVVSENARENVENYKNLWKWSVENLEDFWESVWEFFEIK------SYSDYKTVLDE 83
Query: 67 GRV-FVKFMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTR-ITYRKLLDLVCQ 124
++ K+ E A LN + +K G G+ + + E D R +T+ +L
Sbjct: 84 RKMPGAKWFEGATLNYAEHAF---LKAGEGEAVVYVRE----DGLRRALTWSELERQTAA 136
Query: 125 FANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAK 184
FA L G++KGDRV Y + EAVI +LA A IGA+ V + A+ +R +
Sbjct: 137 FAAWLKDMGVKKGDRVVAYCSQVPEAVIALLATASIGAIWAAVGGEVAPRAVIDRFKQLE 196
Query: 185 AKLLVTADGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEI 244
K+L+ +DG + + + + +E +T + VV + + LK I
Sbjct: 197 PKVLIASDGHFYNGKEF-------NKLEDIKTVVSGIPSLERVVL-IPNLYESHDLKLSI 248
Query: 245 KDLYNWNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLM 304
L+ W E D E L E + + PL+VLYTSG+TG PK +VH G +
Sbjct: 249 P-LHYWEETVDR--KEKLTFEP-------LPFDHPLWVLYTSGTTGIPKPIVHGHGG-IT 297
Query: 305 YAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYW 364
+ D+ D + + W+ +T V + L AT V ++G+P + + W
Sbjct: 298 VEIFKGSFHMDFKEGDRFLWYSPPSWMMWNT--VVSGLLAGATIVFYDGSPLYNFLQPLW 355
Query: 365 SIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYT 424
I K K+ F T+ + M + ++ G + DLSSLR++GS P++P + W Y
Sbjct: 356 QICEKEKLNIFGTSAPFLHGCM-KFGLQPG--SQYDLSSLRMVGSTAAPLSPEGFEWVYR 412
Query: 425 RIGKERCSIVDTFWQTETGG-HVITGLPGATPMKP 458
+ KE D + + +GG V+TG G P+ P
Sbjct: 413 NV-KE-----DVWLNSASGGTDVMTGFVGGCPILP 441
Score = 66.5 bits (155), Expect = 2e-09
Identities = 47/162 (29%), Positives = 78/162 (48%), Gaps = 7/162 (4%)
Query: 523 GYLVFARPWPGMMRTLLEDQDR--FERVYFSKFPGYYCTGDGVRRDEDGYLWITGRIDDM 580
G LV P P M D+D ++ YFS FP + GD + + G I GR D
Sbjct: 471 GELVIELPMPSMPLYFWNDKDFSWYKESYFSMFPNVWWHGDWLMITDRGTAIIFGRSDST 530
Query: 581 LNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALYCFVVLKEGLQFDADLVKTL 640
+ G M T + V+ S + + VV EVKG+ ++ FVV G++ + +L + +
Sbjct: 531 IKRKGVRMGTLDFYKVVESMNEIISSLVV----EVKGK-IFLFVVPAHGIEVNEELKEKI 585
Query: 641 TLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKIAVG 682
+++ +GA+ D I P +P T + K + ++KI +G
Sbjct: 586 NRALKENLGAYFVADYIIPVPDIPMTLNYKKLEVPIKKILLG 627
>UniRef50_UPI0000510398 Cluster: COG0365: Acyl-coenzyme A
synthetases/AMP-(fatty) acid ligases; n=1;
Brevibacterium linens BL2|Rep: COG0365: Acyl-coenzyme A
synthetases/AMP-(fatty) acid ligases - Brevibacterium
linens BL2
Length = 597
Score = 128 bits (308), Expect = 7e-28
Identities = 109/428 (25%), Positives = 168/428 (39%), Gaps = 29/428 (6%)
Query: 27 MYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRVFVKFMEEAELNVCYNLL 86
M ++ E W + W V P + D T G F A ++ +NLL
Sbjct: 1 MIGNHVSSIESNWRPIINTLDWEVEPDE----LFRPDPTGGTWF----PGARIDALHNLL 52
Query: 87 DRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPM 146
R++ D++A WEG P D +TYR+L D V F L G+ GDRVA++
Sbjct: 53 LRHLDT-HSDRLALHWEGE-PGDRESLTYRELADDVATFTAALQKLGVGAGDRVALHTGW 110
Query: 147 ILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGERMYVYKRT 206
+ + MLAC +GA T++ +AL+++ + L+VT DGAWR + K
Sbjct: 111 LPSTAVAMLACTGLGAPWTLIPVSLPVEALSQKFAQLNPTLVVTQDGAWRHGSIIPTKHR 170
Query: 207 CDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIWWHEVLEGES 266
DDA+ + V+ +VV DL N + +
Sbjct: 171 VDDALAAIES-----VEHTIVVRRTGMDVAWFVGDHWYSDLLESNRDR--------RHAA 217
Query: 267 NICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTA 326
P D S P + T G L+ A F WC
Sbjct: 218 RFVSPTSAVDVDTTLCRALVASHDSPALLTSHTVGQLLPNIAAFHRAI--RGPGNLWCAG 275
Query: 327 DVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALM 386
D W+ + + PL T++++EGT P DR II+++ V+ F TAP+ +R++
Sbjct: 276 DASWVVSQWHGLLGPLLFGDTAILYEGTLDIPNRDRAGQIISRFNVSTFLTAPSVMRSI- 334
Query: 387 AHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTETGGHV 446
+ E N S +R + + GE + P W R ++D + Q GG V
Sbjct: 335 REWEDESHNQAN---SGIRRIITAGEAVEPELKAWLRERFKAHGTEVIDGWGQVLLGGIV 391
Query: 447 ITGLPGAT 454
AT
Sbjct: 392 YLRHASAT 399
Score = 55.2 bits (127), Expect = 6e-06
Identities = 46/149 (30%), Positives = 72/149 (48%), Gaps = 10/149 (6%)
Query: 480 GWDRTVM--IVHLPNKSNRTRGFPFFGVEPKILNEDGVEIEGPGE-GYLVFARPWPGMMR 536
GW + ++ IV+L + S P G+ ++ +DG I PGE G +V P PG +R
Sbjct: 381 GWGQVLLGGIVYLRHASAT---MPDCGLH--VIADDGQTIR-PGETGEMVLTTPLPGQVR 434
Query: 537 TLLEDQDRFERVYFSKF-PGYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEG 595
+ R +F P Y TGD V G + GR+DD++++SG L+S + VE
Sbjct: 435 SWEGPGSSSTRDKQQRFGPDRYATGDRVTFSTTGEVIHHGRLDDLVSISGQLISLSAVEN 494
Query: 596 VLASDPRVSEAAVVPKPHEVKGEALYCFV 624
V+ P V ++ + E G A+ V
Sbjct: 495 VIDDHPFVHSSSALVIRREGLGRAVAAVV 523
>UniRef50_A4QIB2 Cluster: Putative uncharacterized protein; n=1;
Corynebacterium glutamicum R|Rep: Putative
uncharacterized protein - Corynebacterium glutamicum
(strain R)
Length = 675
Score = 126 bits (305), Expect = 2e-27
Identities = 118/462 (25%), Positives = 204/462 (44%), Gaps = 35/462 (7%)
Query: 6 YKPTDHVIKKSYLPSIQKYKEMYE-RSLTE--SELFWTEVAQEFQWHVAPKPGGFMKYNF 62
+ PT ++ S + +Y E+ RSL + S L W+ E W + F
Sbjct: 16 WNPTPEQVRSSRMADFARYSEVPAGRSLPDFHSLLDWSVTEVEAFWRSIQSYFDVIGEGF 75
Query: 63 D---ITKGRV--FVKFMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRK 117
D + K V F + A +N N+L R+ N ++ +T +++ +
Sbjct: 76 DTSEVLKEHVMPFASWFPGARVNFAENVL-RHAHNPLLANEPAIYQVEEDGSHTVLSWVQ 134
Query: 118 LLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALA 177
L V A G+ +GDR+A +P + EA+I +LA A IGAV T+ S++A
Sbjct: 135 LESQVASLAATFKELGVERGDRIAAVLPNVPEAIIGLLAAASIGAVWTINSPDLSAEASI 194
Query: 178 ERLSDAKAKLLVTADGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPG 237
R+ + K+LV +DG G + + +R +E + ++V LD
Sbjct: 195 RRVKQLEPKVLVASDGYVFGGKE-IDRREHTAEVEAGLP----SISATVLVRILDTQREP 249
Query: 238 GSLKSEIKDLYNWNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVH 297
G + KD+ + + E + + + E V DPL++L++SG+TG+PKG+VH
Sbjct: 250 GVVSG--KDVKR------LAFDECVN-KPHAPAYERVGFNDPLWILFSSGTTGEPKGIVH 300
Query: 298 TTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYF 357
G ++ D DVY+ A+ W+ +T V L A++V + G+P
Sbjct: 301 GHGGMVLDGLKNISLHQDIGPGDVYYVAANTSWMVWNTLV--QNLLAGASAVTYAGSPKV 358
Query: 358 PKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPA 417
D ++ II+ + VT F T A ++ ++ D S+LR + S G P+ P+
Sbjct: 359 TGKDHHFQIISDFGVTMFATG-AAYLTMVEKAGIDP--RAGRDFSALRSILSTGSPLPPS 415
Query: 418 AWLWYYTRIGKERCSIVDTFWQTETGG-HVITGLPGATPMKP 458
W W + + D +++GG + G G+ PM+P
Sbjct: 416 TWRWVHDAVKS------DVHLGSDSGGTDICGGFLGSNPMEP 451
Score = 68.1 bits (159), Expect = 8e-10
Identities = 49/180 (27%), Positives = 83/180 (46%), Gaps = 3/180 (1%)
Query: 501 PFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQD--RFERVYFSKFPGYYC 558
P GV + + DG + + G + +P P M L D D R++ YF++ G +
Sbjct: 460 PLLGVAVEAHDADG-QPQIDQVGAMAVTKPLPSMPVMLWGDTDGSRYKSSYFTEGEGIWM 518
Query: 559 TGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGE 618
GD + R G + GR D LN G + +++ L +S+ V+ + G
Sbjct: 519 HGDWITRTSSGEFIVHGRADATLNRQGVRIGPSDIYDALTDIEELSDYLVLGIEEDNGGY 578
Query: 619 ALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRK 678
+ FVVL++G++ D L + + +R + A PD I AP +P T + K + L+K
Sbjct: 579 WMPLFVVLEDGVELDDALQQRICTTLRARTSARHVPDEIIVAPDIPVTHTMKRLEVPLKK 638
>UniRef50_Q0S3K9 Cluster: Acetoacetate--CoA ligase; n=10;
Actinomycetales|Rep: Acetoacetate--CoA ligase -
Rhodococcus sp. (strain RHA1)
Length = 647
Score = 124 bits (299), Expect = 8e-27
Identities = 122/456 (26%), Positives = 193/456 (42%), Gaps = 42/456 (9%)
Query: 21 IQKYKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRVFVKFMEEAELN 80
+ Y+ ++ S+ + FW +V F++ A PG + D G V+
Sbjct: 34 VDHYRALWRWSIADPAAFWQDVWDYFEFRSATDPGPALAD--DAMPGAVWFP-------G 84
Query: 81 VCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRV 140
N +D +N A + G D + + + +L V A L G+ GDRV
Sbjct: 85 ATLNYVDHVFRNARPGTPAILYAGEGATDVS-VGWDELRSAVAGLAVTLREHGVGVGDRV 143
Query: 141 AVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGERM 200
Y+P I EAV+ LA A +GAV +S+ A +RL K L+TADG G +
Sbjct: 144 VGYLPNIPEAVVAFLATASLGAVWAACGQDYSAPAALDRLGQLDPKALITADGYRFGGKE 203
Query: 201 YVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIWWHE 260
+ R A + R + +VV HLD S + W + T
Sbjct: 204 H--DRLA--AAAELRGGLPSSA-LTVVVPHLDP-------DSAVDGALTWADAT------ 245
Query: 261 VLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRD 320
G + V + PL+V+++SG+TG PKG+VH G L+ + D R D
Sbjct: 246 ---GRDAVLESVAVPFDHPLWVVFSSGTTGLPKGIVHGHGGVLLEHVKSLALQLDIRRDD 302
Query: 321 -VYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAP 379
++W T+ W+ + A L AT V ++G+P +P D WS++++ VT T+P
Sbjct: 303 TLFWYTSP-SWMMWNFQT--AGLLVGATIVTYDGSPSYPTPDALWSLVSRLGVTVVGTSP 359
Query: 380 TAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQ 439
+ A V + DLS+LR +G G + A+ LW +G+ R +V
Sbjct: 360 GYVLACDKAGVVP---VREHDLSALRAVGVTGSTLPAASSLWLSENVGR-RVPVVSITGG 415
Query: 440 TETGGHVITGLPGATPMKPGAAEKKHPVYYSSMDTF 475
T+ + G P+ PG E P ++D F
Sbjct: 416 TDVVSAFVGGARN-VPVWPG--ELSAPCLGVAVDAF 448
Score = 100 bits (239), Expect = 2e-19
Identities = 67/203 (33%), Positives = 98/203 (48%), Gaps = 5/203 (2%)
Query: 501 PFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQD--RFERVYFSKFPGYYC 558
P GV +E G + G G LV P P M + D D R+ YF FPG +
Sbjct: 439 PCLGVAVDAFDESGQPVRGE-VGELVVTAPMPSMPVSFWNDPDGKRYREAYFDVFPGVWR 497
Query: 559 TGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGE 618
GD + + G + + GR D LN +G M +A++ V+ P V+EA VV G
Sbjct: 498 HGDWITITDRGTVLMHGRSDSTLNRNGIRMGSADIYQVVEKLPEVAEALVVGVDLADGGY 557
Query: 619 ALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRK 678
+ FVVL EG + D L + + +R++ PD I APG+P TR+GK + L++
Sbjct: 558 WMPLFVVLSEGAELDDALKQRIRAAIREQASPRHVPDDIIEAPGIPHTRTGKKLEVPLKR 617
Query: 679 IAVGDH--EVGDISTLADPGVVE 699
I G D S + DPG+++
Sbjct: 618 IFQGADAGRTVDRSAVDDPGLLD 640
>UniRef50_Q9KLB7 Cluster: Acetyl-CoA synthase; n=21; Vibrio|Rep:
Acetyl-CoA synthase - Vibrio cholerae
Length = 649
Score = 124 bits (298), Expect = 1e-26
Identities = 113/450 (25%), Positives = 196/450 (43%), Gaps = 36/450 (8%)
Query: 20 SIQKYKEMYERSLTESELFWTEVAQEFQWHVAPKPG-----GFMKYNFDITKGRVFVKFM 74
+I Y +++ S+ E+ FW EV Q F + + G ++ + R + F
Sbjct: 33 AIDSYSSLHQWSVAETRQFWLEVWQ-FCDVIGYRGNCIIGEGLPRFGKTMVPARDSIWF- 90
Query: 75 EEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGI 134
+A+LN NLL +N D IA W N + ++++L D V L G+
Sbjct: 91 PQAQLNYAENLLSYAFQNP--DGIAL-WFKNENGHTKKFSWQQLCDHVSVVQQWLAQNGV 147
Query: 135 RKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADG- 193
+GD VA Y+P + E VI MLA +GA+ T F +++ ER + K+L +G
Sbjct: 148 GEGDVVAGYLPHLPETVIAMLAATSLGAIWTSTSPDFGVESVIERFGQVQPKILFCCNGY 207
Query: 194 AWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDR-VTPGGSLKSEIKDLYNWNE 252
+ G+ + +R A + V+ C + DR TP ++N+
Sbjct: 208 TFNGKSFPMQERNAQIA-----SALPSLVNTCQIEYLQDRNFTP------------DFND 250
Query: 253 ETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRY 312
W + + DPLFVLY+SG+TGKPK + H+ G L+ +
Sbjct: 251 SFSDWQSIFASYQPRGVEYRRIGFNDPLFVLYSSGTTGKPKCITHSVGGTLLNHLKEHQL 310
Query: 313 VFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKV 372
D +D + GW+ + +V + LA+ AT V+++G P +P+ W+++++ KV
Sbjct: 311 HCDIQPQDRVFYYTTTGWMMWNWHV--SALASGATLVIYDGHPLYPQAGALWALVDEAKV 368
Query: 373 TQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCS 432
+ F T+ + L + + LS L+ L S G + P + + Y + K
Sbjct: 369 SLFGTSAKYLETLQKN---QFSPCDFYSLSHLKTLCSTGSVLYPEQFDYVYEHV-KSDLH 424
Query: 433 IVDTFWQTETGGHVITGLPGATPMKPGAAE 462
+ T+ G + G P +P+ G +
Sbjct: 425 LASISGGTDICGCFVLGNP-ISPVYQGECQ 453
Score = 71.7 bits (168), Expect = 6e-11
Identities = 37/144 (25%), Positives = 76/144 (52%), Gaps = 1/144 (0%)
Query: 540 EDQDRFERVYFSKFPGYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLAS 599
+D R+ + Y+ K+PG + GD + + G + GR D +LN G + TAE+ + +
Sbjct: 494 DDGSRYHQAYWDKYPGVWHHGDEIEITDKGGVLFFGRSDTVLNPGGVRIGTAEIYQQVNA 553
Query: 600 DPRVSEAAVVPKPHEVKGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQN 659
P + ++ + + H + E + FV L + + F+ +L + + L+R++ P I
Sbjct: 554 LPEIHDSIAIGR-HIDRDEQVILFVQLAQNVPFNDELQQKIRSLLRERCSPRHVPAHIYA 612
Query: 660 APGLPKTRSGKIMRRILRKIAVGD 683
+P+T+SGK++ ++++ GD
Sbjct: 613 ISEIPRTKSGKLVELAVKQVCHGD 636
>UniRef50_Q87H07 Cluster: Acetyl-CoA synthase; n=13;
Vibrionales|Rep: Acetyl-CoA synthase - Vibrio
parahaemolyticus
Length = 677
Score = 124 bits (298), Expect = 1e-26
Identities = 105/392 (26%), Positives = 180/392 (45%), Gaps = 31/392 (7%)
Query: 76 EAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIR 135
+ LN NLL ++ I F N + +++ ++L++ V L+A G+
Sbjct: 97 DTTLNYAQNLLVHAEQSPERQLIVF---SNESGEQKQLSGQQLIEQVSIVQQWLIANGVG 153
Query: 136 KGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAW 195
KGD VA Y+P + E VI MLA +GA+ T F D++ ER K+L +G
Sbjct: 154 KGDVVAAYLPYLPETVIAMLATTSLGAIWTSTSPDFGVDSVLERFGQVTPKVLFCCNGYQ 213
Query: 196 RGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETD 255
G +++ D +K R ++ + V +D +TP SE+ ++
Sbjct: 214 FGGKIF-------DMTQKNRA-ISSKLGNTISVCQIDYLTP----SSELTPRDERSDSDF 261
Query: 256 IWWHEVLEGESNICPP----EWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFR 311
I W E+ E +I P + DPLF+LY+SG+TG+PK +VH+ G L+ +
Sbjct: 262 ITWSELSE---HIAPQSVHYQPALFNDPLFILYSSGTTGQPKCIVHSVGGTLLNHLKEHQ 318
Query: 312 YVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYK 371
D D + GW+ + +V + LA+ AT V+++G+P +P W + +
Sbjct: 319 LHCDVKPLDKVFYYTTCGWMMWNWHV--SALASGATLVIYDGSPVYPDHSVLWRLAEEQS 376
Query: 372 VTQFYTAPTAIRAL-MAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKER 430
V+ F T+ + AL A+Y+ + +L SL+ L S G + P + + Y I K+
Sbjct: 377 VSLFGTSAKYLEALEQANYSPRSEH----NLDSLKTLCSTGSVLYPEQFSYVYQHI-KQD 431
Query: 431 CSIVDTFWQTETGGHVITGLPGATPMKPGAAE 462
+ T+ G + G P +P+ G +
Sbjct: 432 LHLASIAGGTDICGCFVLGNP-ISPVYKGECQ 462
Score = 64.9 bits (151), Expect = 7e-09
Identities = 51/199 (25%), Positives = 89/199 (44%), Gaps = 4/199 (2%)
Query: 504 GVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQ-DRFERVYFSKFPGYYCTGDG 562
G K+L++ G E+ G L P D +R+ Y+SKF + D
Sbjct: 467 GNNVKVLDDAGSEVVSQ-RGELTCNNSLPNFPIGFWHDNGERYHDAYWSKFADTWHHSDD 525
Query: 563 VRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALYC 622
V + +G GR D LN G + TAE+ + + + ++ V K + + E ++
Sbjct: 526 VMQTANGGFIFYGRSDATLNPGGVRIGTAEIYQQVNALSGIEDSIAVGKLSQ-QSEEIWL 584
Query: 623 FVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKIAVG 682
FV L + ++ L + ++ K P I +P+TRSGK + +++ AV
Sbjct: 585 FVKLSQSVELTPQLTDLIRQTLKTKCSPRHIPRKIFALSDIPRTRSGKTVELAVKQ-AVN 643
Query: 683 DHEVGDISTLADPGVVEEL 701
V +I +A+P V+EE+
Sbjct: 644 GQTVKNIGAIANPEVLEEI 662
>UniRef50_Q4P432 Cluster: Putative uncharacterized protein; n=1;
Ustilago maydis|Rep: Putative uncharacterized protein -
Ustilago maydis (Smut fungus)
Length = 709
Score = 122 bits (295), Expect = 3e-26
Identities = 112/423 (26%), Positives = 190/423 (44%), Gaps = 32/423 (7%)
Query: 21 IQKYKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRVFVKFMEEAELN 80
++ Y ++++ S T FWT V E V G + D ++ + A LN
Sbjct: 48 LRTYDQLWQWSCTHLNDFWTTVWDETA--VISSVGAPLAIG-DNAPIYPPPRWFQGARLN 104
Query: 81 VCYNLLDRNVKNGFG-DKIAFFWEGNSPD------DYTRITYRKLLDLVCQFANGLLAKG 133
NLL ++ D +A + D D + I+Y +L +V Q A L ++G
Sbjct: 105 FAENLLRHGTRSSANRDDVAVI-QSTEVDTTTGELDESSISYAQLYSMVAQAAAALRSRG 163
Query: 134 IRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADG 193
I+K D VA Y + +I LA + IGAV T A F + + ERL + K+L++ +
Sbjct: 164 IQKNDCVASYSANNTQNLIAFLAASSIGAVWTSAAADFGPEGVLERLRTVRPKVLISVNA 223
Query: 194 AWRGERMYVY---KRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNW 250
+++ + R+ + +E R + R++ +V+ H+ + P L+ D W
Sbjct: 224 VRYNGKVHDHLAKLRSVVEGLEHDRDEQEQRLEGVVVIPHV-KTHP--VLEPHAGDAARW 280
Query: 251 NEETDIWWHEVLEGESNICPP---EWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAA 307
W H V EG S + P E + PL++L++SG+TGKPK + H G L+ +
Sbjct: 281 TS----WDHFVAEGASAVDQPIAFEQLDFNHPLWILFSSGTTGKPKAITHRAGGMLLQLS 336
Query: 308 ATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSII 367
R DV++ GW+ + V A L T V+++G+P P V W +
Sbjct: 337 KEHIIHGGLTRSDVFFQHTTTGWMMWNFLV--AGLVTGCTIVLYDGSPLKP-VSVLWELA 393
Query: 368 NKYKVTQFYTAPTAIRAL-MAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRI 426
K+ VT F T+ + AL + Y V + + +R + S G P+ + + + RI
Sbjct: 394 EKHGVTTFGTSAAYLGALEKSGYEVGANHAEL----CVRQILSTGSPLRAELYAFIHQRI 449
Query: 427 GKE 429
G +
Sbjct: 450 GSD 452
Score = 51.6 bits (118), Expect = 7e-05
Identities = 43/168 (25%), Positives = 77/168 (45%), Gaps = 8/168 (4%)
Query: 523 GYLVFARPWPGM-MRTLLEDQDRFERVYFSKFPGYYCTGDGVRRDEDGYLWITGRIDDML 581
G ++ P+P + + + ++ Y+S+ G + GD + E G + + GR D +L
Sbjct: 509 GDMICKSPFPAQPLGFWKQPESKYFDSYYSQVSGVWYHGDFIMLSEHGGVVMLGRSDGIL 568
Query: 582 NVSGHLMSTAEVEGVLASDPR-----VSEAAVVP-KPHEVKGEALYCFVVLKEGLQFDA- 634
N G ++E+ +L S ++++ VV K E + FVVL ++ D
Sbjct: 569 NPGGIRFGSSEIYELLESPDNAFASWITDSLVVALKTPRADDEVVCLFVVLDPAVRIDVQ 628
Query: 635 DLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKIAVG 682
L +L L+R K P I+ +PKT +GK + ++KI G
Sbjct: 629 QLEHSLVSLIRTKRSPRHVPKFIKIVSDIPKTLNGKKVEVPVKKIING 676
>UniRef50_Q9HI39 Cluster: Probable SA protein; n=4;
Thermoplasma|Rep: Probable SA protein - Thermoplasma
acidophilum
Length = 528
Score = 121 bits (292), Expect = 6e-26
Identities = 113/399 (28%), Positives = 176/399 (44%), Gaps = 56/399 (14%)
Query: 282 VLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAP 341
+ +TSG+ G PK V+H Y + T R++ D +D +W + GW Y+P
Sbjct: 161 IFFTSGTEGNPKMVLHNNT-YPLGHRTTVRWL-DLRAQDTHWNISSPGWAKWGWSSYYSP 218
Query: 342 LANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDL 401
+ + +T + P+V + K+ +T PT R + ++ NL
Sbjct: 219 MISGSTVFNMRYRKFDPEV--ALKAMEKFLITSICAPPTVWRMFLLQ-DLSSMNL----- 270
Query: 402 SSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTETGGHVITGLPGATPMKPGAA 461
LR S GEP+NP +G ++ D + Q+E+ ++ G +KPG+
Sbjct: 271 -HLRKAASAGEPLNPEIIDRIRQYLG---VTVKDGYGQSES--TLMVGNLEKQTVKPGSM 324
Query: 462 EKKHPVYYSSMDTFRPKQGWDRTVMIVHLPNKSNRTRGFPFFGVEPKILNEDGVEIEGPG 521
+ +D +R +V + + NR + P V+I
Sbjct: 325 GR-------PLDPYR----------VVIVDDAGNR--------LPPNTTGHIAVDIGERP 359
Query: 522 EGYLVFARPWPGMMRTLLEDQDRFER-VYFSKFPGYYCTGDGVRRDEDGYLWITGRIDDM 580
G V P + R DRF +Y++ GY DEDGYLW R DD+
Sbjct: 360 NGLFVSYMNDPSLTR------DRFRNGLYYTGDMGY--------MDEDGYLWFVSRSDDV 405
Query: 581 LNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALYCFVVLKEGLQFDADLVKTL 640
+ S + + EVE L P V+E+AVV P E++G+ + FVVLK G DL + L
Sbjct: 406 IKSSDYRIGPFEVESALLRHPAVAESAVVGTPDEIRGDLVKAFVVLKSGYTPSQDLAREL 465
Query: 641 TLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKI 679
++ VR +G A P I+ LPKT SGKI+R+ LRK+
Sbjct: 466 SIHVRNLVGPHARPRKIEFVGELPKTISGKIIRKELRKL 504
>UniRef50_Q7S7A6 Cluster: Putative uncharacterized protein
NCU01417.1; n=1; Neurospora crassa|Rep: Putative
uncharacterized protein NCU01417.1 - Neurospora crassa
Length = 709
Score = 119 bits (287), Expect = 2e-25
Identities = 95/320 (29%), Positives = 153/320 (47%), Gaps = 42/320 (13%)
Query: 26 EMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNF-DITKGRVFV--KFMEEAELNVC 82
E SLT+ E FW A++ WH KP +K D+ G ++ + E++ C
Sbjct: 61 EAQHLSLTDPEGFWGHQAEQLHWH--RKPSAVLKRTTKDLKLGTSHSHWEWFPDGEISTC 118
Query: 83 YNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAV 142
YN LDR+V G GD+ A ++ + + R+TY++LL V FA L +G++KGD V V
Sbjct: 119 YNCLDRHVLAGHGDQPAILYDSSVTNTKQRLTYKQLLAEVETFAGVLREEGVKKGDVVLV 178
Query: 143 Y------------------------MPMILEAVICMLACARIGAVHTVVFAGFSSDALAE 178
Y +PM+ +I +LA R+GA+H VVF GF+S ALA+
Sbjct: 179 YSQFTQLRLSRVSTEPATDSLPIYIVPMVPATLIGILAINRLGAIHAVVFGGFASTALAQ 238
Query: 179 RLSDAKAKLLVTADGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRV-TPG 237
R+ ++ ++TA G + V R IE+A + + ++ V P
Sbjct: 239 RIEASRPVAILTASCGIEGNKGPVSYRA---YIEEAISISSFKPPKTIIWQREQLVWRPI 295
Query: 238 GSLKSEIKDLYNWNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVH 297
+ E +W + ++ E C P V + DP++++YTSG+TG+PKGVV
Sbjct: 296 KKTEGE----RDWQKLVKSARFRNIKVE---CVP--VRSADPIYIIYTSGTTGRPKGVVR 346
Query: 298 TTAGYLMYAAATFRYVFDYH 317
+ G+ + + Y+F H
Sbjct: 347 DSGGHAVGLHMSISYLFGIH 366
Score = 111 bits (266), Expect = 8e-23
Identities = 96/314 (30%), Positives = 150/314 (47%), Gaps = 41/314 (13%)
Query: 401 LSSLRVLGSVGEPINPAAWLWYYT---RIGKERCSIVDTFWQTETGGHVITGLPGATPMK 457
L SL+ L GE PA Y R G +VD +W +E+G + +
Sbjct: 396 LKSLKALFLAGERSEPAIINMYQDLLRRYGAAGSQVVDNWWSSESGSPI-----SGVALV 450
Query: 458 PGAAEKKHPVYYSSMDTFRPKQGWDRTVMIVHLPNKSNRTRGFPFFGVEPKILNEDGVEI 517
P A + + ++M P LP K + G G + ++++++G E+
Sbjct: 451 PHAGKNRK----TNMKDHPP------------LPIKPG-SAGKAMPGFDVRVVDDEGNEV 493
Query: 518 EGPGEGYLVFARPW-PGMMRTLLEDQDRFERVYFSKFPGYYC-TGDGVRRDEDGYLWITG 575
G +V P P RTL D++RF + Y +F G + TGD D+ GY+ I
Sbjct: 494 PRGNMGNIVLGLPLAPTAFRTLWGDEERFYKSYMIRFNGKWVDTGDAGYVDQTGYIHIMA 553
Query: 576 RIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALYCFVVLKEG---LQF 632
R DD++NV+ H +E + S P V+EA VV P +KG+ + FV +G ++
Sbjct: 554 RTDDIINVAAH----RTLEQAVTSHPLVTEACVVSVPDALKGQLPFAFVSTSDGGADVKS 609
Query: 633 DADLVKTLTLLVRQKIGAFAAPDTIQNAPG-LPKTRSGKIMRRILRKI---AVGDH---E 685
D L + + LVR ++GA A+ + G +PKTRSGK +RR+LR++ AV D
Sbjct: 610 DEQLFQDIQKLVRAQVGAIASLGGMIRGKGMIPKTRSGKTLRRVLRELLENAVHDEFEKP 669
Query: 686 VGDISTLADPGVVE 699
+ ST+ DP VV+
Sbjct: 670 INIPSTVEDPSVVD 683
>UniRef50_Q6U666 Cluster: Putative uncharacterized protein; n=1;
Klebsiella pneumoniae|Rep: Putative uncharacterized
protein - Klebsiella pneumoniae
Length = 579
Score = 118 bits (285), Expect = 4e-25
Identities = 71/201 (35%), Positives = 108/201 (53%), Gaps = 13/201 (6%)
Query: 267 NICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTA 326
N+ P W+AA P +L+TSG+TG PKG+V T GY + A+ ++F ++++ TA
Sbjct: 222 NVVPCTWLAASAPSHLLFTSGTTGTPKGIVRDTGGYAVALLASLVHLFRLRDDEIFFTTA 281
Query: 327 DVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALM 386
D GW+TGH+Y +Y PL T+V+ E + +W ++ +T+ T AIR M
Sbjct: 282 DAGWVTGHSYGIYGPLLAGLTTVLCEVN---SPGEYWWQMVETLGITRMLTIAGAIR--M 336
Query: 387 AHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTETGGHV 446
A G DL+SLR L GEP++ A W ++G C + +WQTE+G +
Sbjct: 337 AR---RQGK-PRADLTSLRTLYLAGEPLDNATDEWVAAQLGVP-CE--NHYWQTESGWPL 389
Query: 447 ITGLPGA-TPMKPGAAEKKHP 466
+ G A +P+ AAE HP
Sbjct: 390 LAGSGRALSPVFTRAAEVVHP 410
Score = 74.9 bits (176), Expect = 7e-12
Identities = 60/182 (32%), Positives = 89/182 (48%), Gaps = 8/182 (4%)
Query: 501 PFFGVEPKILNEDGVEIEGPGE-GYLVFARPW-PGMMRTLLEDQDRFERVYFS--KFPGY 556
P F ++++ + PGE G LV PG M TL ++ + ++ Y+S +
Sbjct: 399 PVFTRAAEVVHPASGKTCAPGETGMLVINNTLGPGGMSTLWQNDIQHDQYYWSYRQRQWR 458
Query: 557 YCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVK 616
Y T D R + + I GR+DD++N+ G ++TAE+E L V E H +
Sbjct: 459 YATHDCAIRVGERII-IQGRMDDVMNIGGKRIATAEIENALMGLEGVVEVVAAGTAHYLL 517
Query: 617 GEALYCFVV--LKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRR 674
GE + FVV + + Q A L K + + + G FA P I LPKT SGK+MRR
Sbjct: 518 GEMVALFVVTDIADPAQ-QAALKKNICARLVARCGRFAVPRRIHITSALPKTFSGKVMRR 576
Query: 675 IL 676
IL
Sbjct: 577 IL 578
Score = 69.3 bits (162), Expect = 3e-10
Identities = 37/110 (33%), Positives = 65/110 (59%), Gaps = 2/110 (1%)
Query: 80 NVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDR 139
N+ +N LDR++ G+K A + R++YR+L V + + + G++ GDR
Sbjct: 74 NLSFNALDRHLAEK-GEKCAIIHRDYLGQTH-RLSYRELWQQVNTLCSMMQSWGVKPGDR 131
Query: 140 VAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLV 189
V + +PM + MLACARIGAVH V+++ + +AL +R++ ++ LL+
Sbjct: 132 VLIALPMTPLVAVAMLACARIGAVHVVLYSSITHEALMQRIAVSQPVLLL 181
>UniRef50_Q4JHB4 Cluster: Acetoacyl-CoA synthetase; n=2; cellular
organisms|Rep: Acetoacyl-CoA synthetase - Amanita
muscaria (Fly agaric)
Length = 702
Score = 118 bits (283), Expect = 7e-25
Identities = 102/423 (24%), Positives = 183/423 (43%), Gaps = 25/423 (5%)
Query: 11 HVIKKSYLPSIQKYKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRVF 70
H++ + + Y ++Y+ S + FW+ V +F +V G + N
Sbjct: 24 HLVNSMHDLRLSSYYDLYQWSTKHIDYFWSLV-WDFT-NVIGHKGEHVVDNAATPSANP- 80
Query: 71 VKFMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYT-----RITYRKLLDLVCQF 125
++ +A+LN N+L DKIA D+Y + TY +L LV
Sbjct: 81 -QWFSDAKLNWAENMLQCRSP----DKIALVHATEPTDEYPNPELRQCTYAQLYTLVADL 135
Query: 126 ANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKA 185
+ LL G++ GDRVA Y +E V LA IG + A F + + ERL +
Sbjct: 136 VSALLLNGLKPGDRVASYSSNCIENVAACLATTAIGGIWVSAAADFGPEGVLERLEQVQP 195
Query: 186 KLLVTADGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIK 245
+ AD +++ + +E+ R+ +H ++++ + + P + E
Sbjct: 196 AFVFAADAVVYNAKVHNHISKVSVLLERLRSKGQH-PSKVIIIHAIPQPAPQHEWRPEWT 254
Query: 246 DLYNW-NEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLM 304
+ +E + GE + C ++ + PL++L++SG+TG PK +VH G L+
Sbjct: 255 SWEAFISEGQTAKLGQTASGEIDWCR---LSFDAPLWILFSSGTTGPPKPIVHRAGGMLL 311
Query: 305 YAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPY-FPKVDRY 363
A F D +DV++ GW+ + + + L T V+++G+P P
Sbjct: 312 QAKKEFIICADLESQDVFFYYTTTGWMMWNFLI--SGLGVGCTLVLYDGSPLRRPSFLWL 369
Query: 364 WSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYY 423
W +++K +T F T+ I L Y + + +L SLR L S G P+ P + + Y
Sbjct: 370 WGLVDKLGITIFGTSAKYIDQLSRSYKPRENH----NLQSLRHLYSTGSPLAPNLFDFIY 425
Query: 424 TRI 426
+
Sbjct: 426 KHV 428
Score = 49.6 bits (113), Expect = 3e-04
Identities = 54/189 (28%), Positives = 79/189 (41%), Gaps = 26/189 (13%)
Query: 520 PGE-GYLVFARP--------WP----GMMRTLLEDQDRFERVYFSKFPGYYCTGDGV--- 563
PGE G LV ARP WP G + RFE+ YF++ G + GD +
Sbjct: 482 PGEPGELVCARPFPCIPLGFWPLPGYGQEGDEKTARSRFEQSYFAEHNGVWYHGDHIVIT 541
Query: 564 --RRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLA---SDPR-----VSEAAVVPKPH 613
+ G + + GR D +LN G +AE+ V+ S P V AV K
Sbjct: 542 RSKAGNGGGVIMLGRSDGVLNPGGVRFGSAELYDVIELCFSSPTSPFTVVDSLAVAQKID 601
Query: 614 EVKGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMR 673
E + FV L G Q + V+ + +R + P I P +P T +GK +
Sbjct: 602 RGLDERVILFVKLTNGQQLSNEFVQRINSEIRSRRSPRHIPAKIIQVPDIPYTLNGKRVE 661
Query: 674 RILRKIAVG 682
+++KI G
Sbjct: 662 VLVKKIING 670
>UniRef50_Q5LKI0 Cluster: Benzoate-coenzyme A ligase; n=33;
Bacteria|Rep: Benzoate-coenzyme A ligase - Silicibacter
pomeroyi
Length = 540
Score = 116 bits (278), Expect = 3e-24
Identities = 121/401 (30%), Positives = 174/401 (43%), Gaps = 59/401 (14%)
Query: 277 EDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTY 336
+D + +TSG+TG PK +H L+ A R V DV+ + + + G
Sbjct: 195 DDVALLGFTSGTTGDPKATMHFHRDLLIIADGYAREVLGVVPEDVFIGSPPLAFTFGLGG 254
Query: 337 VVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNL 396
+ PL A + + E V+ II +Y+ T +TAPTA R ++ +E+G
Sbjct: 255 LAVFPLRFGAAATLLEQASPPNMVE----IIQQYRATVCFTAPTAYRFMLKA--MEEG-- 306
Query: 397 TMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTETGGHVITGLPGATPM 456
DLSSLR S GE + PA + D W +TG ++ G+
Sbjct: 307 --ADLSSLRAAVSAGETL-PAP--------------VYDE-WIAKTGKPMLDGI------ 342
Query: 457 KPGAAEKKHPVYYSSMDTFRPKQGWDRTVMIVHLPNKSNRTRGFPFFGVEPKILNEDGVE 516
GA E H + D RP G P G + +IL+E+G E
Sbjct: 343 --GATEMLHIFISNRFDDHRPA------------------CTGKPVTGYQVRILDENGNE 382
Query: 517 IEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYCTGDGVRRDEDGYLWITGR 576
G L P R L +D+ + Y G+ TGD D+DGYL R
Sbjct: 383 APRGEVGRLAVRGPTG--CRYLADDR---QSGYVQN--GWNVTGDSFVMDDDGYLHFAAR 435
Query: 577 IDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALYCFVVLKEGLQFDADL 636
DDM+ SG+ ++ EVE L S P V+E V+ P E +G + VVL G DA +
Sbjct: 436 SDDMIVSSGYNIAGPEVEAALLSHPAVAECGVIGAPDEARGHIVEAHVVLTPGHTGDALM 495
Query: 637 VKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILR 677
VKTL V+ I + P +++ LPKT++GKI R LR
Sbjct: 496 VKTLQDHVKATIAPYKYPRSVRFIEALPKTQTGKIQRFRLR 536
Score = 40.7 bits (91), Expect = 0.13
Identities = 30/86 (34%), Positives = 40/86 (46%), Gaps = 7/86 (8%)
Query: 79 LNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAK-GIRKG 137
LNV L D V GFGD A G R TY++L D + A+ L+ G++ G
Sbjct: 36 LNVGVELTDAMVDKGFGDHTALIGNGR------RRTYKELSDWTNRLAHVLVEDLGVKPG 89
Query: 138 DRVAVYMPMILEAVICMLACARIGAV 163
+RV + V C LA + GAV
Sbjct: 90 NRVLIRSANNPAMVACWLAATKAGAV 115
>UniRef50_Q1V1I6 Cluster: Acetoacetyl-CoA synthase; n=2;
Bacteria|Rep: Acetoacetyl-CoA synthase - Candidatus
Pelagibacter ubique HTCC1002
Length = 653
Score = 116 bits (278), Expect = 3e-24
Identities = 106/411 (25%), Positives = 182/411 (44%), Gaps = 37/411 (9%)
Query: 22 QKYKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRVFVK--FMEEAEL 79
QKY+ + + S+ FW+ + W + G K I K ++F K F+ ++L
Sbjct: 35 QKYESILKWSIENPGNFWSSI-----WDFSEIKG--FKSKIKIKKSKIFYKNKFLLNSKL 87
Query: 80 NVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDR 139
N NLL +N K DK F NS + ++++L V + + L + I++ DR
Sbjct: 88 NFAENLLSKNNK----DKAITFISENSFREER--SWQELNLNVSKISKFLKSINIKEKDR 141
Query: 140 VAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGER 199
+A YMP +E V +A + +GA+ + F + ER S K+L D
Sbjct: 142 LAAYMPNTIETVEAFIASSSLGAIWSSCSPDFGVKGVVERFSQISPKVLFVVD------- 194
Query: 200 MYVYKRTCDDAIEKARTFFKH--RVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIW 257
Y Y + +E+ K ++ ++ N+ PG + +K+ Y++ + +
Sbjct: 195 KYFYNGKIINILERIPLILKEIPSIEYVVIANY-----PG---EKYLKNKYSYKKVKVLK 246
Query: 258 WHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYH 317
W+E+++ ES E L +LY+SG+TGKPK + H + G L+ + D
Sbjct: 247 WNELMKKESEKIQFSKFDFEQDLAILYSSGTTGKPKCICHRSGGVLLQHKKEHQLHCDIR 306
Query: 318 RRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYT 377
D + GW+ + V + LA+ A+ V+F+G+P + K D I K K+T F
Sbjct: 307 EGDNVFYFTTCGWMMWNWLV--SVLASKASIVLFDGSPMYKKNDLLLKIAEKEKITLFGI 364
Query: 378 APTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGK 428
+ + AL LS LR + S G P++ + + Y I K
Sbjct: 365 SAKYVDALRKSKPTLKYKY---KLSKLRTICSTGSPLSNDGFKYIYENIKK 412
Score = 75.4 bits (177), Expect = 5e-12
Identities = 52/202 (25%), Positives = 95/202 (47%), Gaps = 5/202 (2%)
Query: 504 GVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQD--RFERVYFSKFPGYYCTGD 561
G+ + NE G ++ +G LV P+P M D++ +F++ YF+ F + GD
Sbjct: 449 GMNVDVFNEKGEPLKNK-KGELVCKNPFPSMPLKFWNDKNDIKFKKAYFNNFLNTWYHGD 507
Query: 562 GVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALY 621
+ G I GR D LN G + TAE+ + + E+ VV + + +
Sbjct: 508 YAEIKKGGGFIIHGRSDTTLNPGGVRLGTAEIYSEVEKFIEIKESIVVGQAWD-NDVRII 566
Query: 622 CFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKIAV 681
F+VL + DL+K + + +R+ P I +P+T++GKI+ ++
Sbjct: 567 LFIVLNPKYVLNEDLLKKIKIQIRKNASPRHVPSKIIVVDDIPRTKNGKIVELAVKNTIE 626
Query: 682 GDHEVGDISTLADPGVVEELFN 703
G +E+ + LA+P V+++ N
Sbjct: 627 G-NEIKNKEALANPRVLDQYKN 647
>UniRef50_Q55RP2 Cluster: Putative uncharacterized protein; n=2;
Filobasidiella neoformans|Rep: Putative uncharacterized
protein - Cryptococcus neoformans (Filobasidiella
neoformans)
Length = 698
Score = 116 bits (278), Expect = 3e-24
Identities = 114/428 (26%), Positives = 196/428 (45%), Gaps = 41/428 (9%)
Query: 13 IKKSYLPSIQKYKEMYERSLTESELFWTEVAQEFQW-HVAPKPGGFMKYNFDITKGRVFV 71
I K + S+ Y +++E S FW+ + + W HV G +K N +
Sbjct: 27 INKIHSLSLTTYADLWEWSCAHRSDFWSAL---WDWEHVIGDKG--VKENGKVVDEDKTP 81
Query: 72 K----FMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYT----RITYRKLLDLVC 123
+ + E+ LN N L R+ K+ D IA Y +IT +L LV
Sbjct: 82 EENPPWFTESSLNWAENQL-RHAKSR-PDDIAIIQVCEPCSTYVPSIKQITQFELYSLVG 139
Query: 124 QFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDA 183
+ L A G+ KGDRVA + LEAV+ +LA + +G + + A F D + ERL
Sbjct: 140 KAQRSLRAAGVGKGDRVAFWGGNCLEAVVTVLATSSLGGIFSSAAADFGIDGVVERLEQI 199
Query: 184 KAKLLVTADGA-WRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHL-DRVTPGGSLK 241
+ K+LV +G + G + R + K+ + + V+HL + + P
Sbjct: 200 QPKVLVVTNGVIYAGTPRPLLPR-----VAPLLNILKNPPSVVVSVDHLPEELVP---TF 251
Query: 242 SEIKD-LYNWNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTA 300
+E+K+ L W++ W + +GE + + ++P+++L++SG+TGKPK +VH
Sbjct: 252 AEVKEKLVRWDD-----WLDQEDGEVDFLR---MGFDEPIWILFSSGTTGKPKAIVHRQG 303
Query: 301 GYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKV 360
G L+ + D D+++ GW+ Y++ + LA AT V++EG+P
Sbjct: 304 GMLLDSLREHHLAGDISSSDIFFYYTTPGWMM-FQYLI-SGLATGATIVLYEGSP-LKLP 360
Query: 361 DRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWL 420
WS+I+ +T F T+ I + HY N DL +L+ + S G P+ +
Sbjct: 361 SHLWSLIDDLGITVFGTSAKWIEQVEKHYPDVGKN---HDLKTLKQILSTGSPLPGRLFD 417
Query: 421 WYYTRIGK 428
+ Y ++ K
Sbjct: 418 FIYEKVKK 425
Score = 41.5 bits (93), Expect = 0.076
Identities = 47/173 (27%), Positives = 72/173 (41%), Gaps = 13/173 (7%)
Query: 540 EDQDRFERVYFSKFPGYYCTGDGV-----RRDEDGYLWITGRIDDMLNVSGHLMSTAEVE 594
E + RF+ YF G + GD V R G L + GR D +LN G ++
Sbjct: 505 EAKKRFKDSYFKGDKGIWYHGDYVQITPSRLGNGGGLIMLGRSDGVLNPGGIRFGPTDIY 564
Query: 595 GVLAS----DPRVSEAAVVPKPHEVKG-EALYCFVVLKEGLQFDADLVKTLTLLVRQKIG 649
VL + V E VV + E + FV ++ G + D L+ + +R
Sbjct: 565 SVLENLTFAKEGVEETLVVGLMCDGGADEKVVLFVKMRGGKELDDGLLAKIRASIRTARS 624
Query: 650 AFAAPDTIQNAPGLPKTRSGKIMRRILRKIAVGDHEVGDI--STLADPGVVEE 700
A P I +P T +GK + +RK+ + + I STL +P +EE
Sbjct: 625 ARHVPAKIIQVSDIPVTLTGKRVEVPIRKV-INGAPISSINPSTLQNPECLEE 676
>UniRef50_Q8ESW2 Cluster: Acetoacetyl-CoA synthetase; n=1;
Oceanobacillus iheyensis|Rep: Acetoacetyl-CoA synthetase
- Oceanobacillus iheyensis
Length = 661
Score = 115 bits (276), Expect = 5e-24
Identities = 86/299 (28%), Positives = 142/299 (47%), Gaps = 25/299 (8%)
Query: 133 GIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTAD 192
G+ KGDRV Y P I E V+ LA + +GA+ + F ++ ER + K+++T D
Sbjct: 139 GVTKGDRVVSYAPNIYETVVAFLATSSLGAIWSSASPDFGKQSVIERFQQIEPKVMITID 198
Query: 193 GAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNE 252
G G + + R IE+ ++ ++ + + +L T +LK I W +
Sbjct: 199 GYQYGGKS--FDRMA--IIEEIQSTIP-SLEATIAIPYLHADTDFSNLKQPI----TWKD 249
Query: 253 ETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLM-YAAATFR 311
H E P V DPL+VLY+SG+TGKPK +VH+ G L+ + AT
Sbjct: 250 AV----HTSKPLELTFTP---VGFNDPLWVLYSSGTTGKPKAIVHSQGGMLLEHLKATHL 302
Query: 312 YV-FDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKY 370
++ D + R +W T GW+ + V L N + ++++G+P +P W
Sbjct: 303 HLDLDQNSR-FFWFTT-TGWMMWNFLV--GGLLNGSCIILYDGSPSYPDERFLWKFAEDT 358
Query: 371 KVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKE 429
K+T F T+ + I + M + DLS+L+ + S G P+ P + W YT + K+
Sbjct: 359 KMTVFGTSASFITSSMKKDIHPEEEF---DLSALKNISSTGSPLPPEGFQWCYTHVKKD 414
Score = 64.1 bits (149), Expect = 1e-08
Identities = 47/186 (25%), Positives = 85/186 (45%), Gaps = 6/186 (3%)
Query: 523 GYLVFARPWPGMMRTLLEDQD--RFERVYFSKFPGYYCTGDGVRRDEDGYLWITGRIDDM 580
G LV +P+P M D D R YF + G +C GD ++ E G I GR D
Sbjct: 468 GELVLTKPFPCMPIFFWNDDDGMRMYHSYFDTYRGVWCHGDYIKITEKGTSIIYGRSDAT 527
Query: 581 LNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALY-CFVVLKEGLQFDADLVKT 639
+N G + T+E+ + V ++ ++ P + G+++ FVV+K F ++ +
Sbjct: 528 INRGGIRIGTSEIYRAVDQIEEVEDSLMIDLP-QTNGDSITPLFVVMKNSKPFTDEVKNS 586
Query: 640 LTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKIAVGD--HEVGDISTLADPGV 697
+ ++ P + LPKT +GK + ++KI +G+ +V + +L +
Sbjct: 587 IKNNLKTHCSPRHVPTHMFEVKELPKTLNGKKIEVPIKKILMGESFEQVMNKGSLINESA 646
Query: 698 VEELFN 703
+E N
Sbjct: 647 IEYFIN 652
>UniRef50_Q97WK0 Cluster: Acetyl-CoA synthetase; n=4;
Sulfolobaceae|Rep: Acetyl-CoA synthetase - Sulfolobus
solfataricus
Length = 571
Score = 114 bits (274), Expect = 9e-24
Identities = 78/205 (38%), Positives = 114/205 (55%), Gaps = 12/205 (5%)
Query: 499 GFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYC 558
G PF ++E+G + G G+LV P+P + +D+D+F YF KF +
Sbjct: 371 GLPFPAAVIDTVDENGKSLRGH-IGHLVAREPFPTQFIGIWKDEDKFLS-YFEKFNSHD- 427
Query: 559 TGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGE 618
TGD DE GY+ I GR DDM+ ++GH +++ EVE V+ S + E+A V P E+KGE
Sbjct: 428 TGDLAIIDEKGYVKIVGRDDDMIKIAGHRITSGEVESVINSLQGIIESAAVGIPDEIKGE 487
Query: 619 ALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRK 678
L F V G D +V T VR+ +G D I LPK+RSGKI+RR+LR
Sbjct: 488 KLVVFYV---G-NVDERIVAT---KVREMLGPIYVIDKIYKVERLPKSRSGKIVRRVLRD 540
Query: 679 IAVGDHEVGDISTLADPGVVEELFN 703
+ +G E+ D + L DP +++E+ N
Sbjct: 541 LLLG-KEI-DETILEDPEILKEIKN 563
Score = 89.8 bits (213), Expect = 2e-16
Identities = 55/183 (30%), Positives = 95/183 (51%), Gaps = 18/183 (9%)
Query: 24 YKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRVF--VKFMEEAELNV 81
Y +Y+ SL + E +W A + F K+ I K + K+ N+
Sbjct: 3 YYTLYDLSLEKPETYWETFANRLSF--------FKKWEKVIEKNKQLPIAKWFINGTTNI 54
Query: 82 CYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVA 141
YN L+ G + F+ E D IT+ +L ++ A LL KG+R+GDR+A
Sbjct: 55 AYNALNHG-----GKALIFYQENKHKGD--EITFDELNNMSSMIAGLLLDKGVRRGDRIA 107
Query: 142 VYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAW-RGERM 200
+YMP + + +LA AR+GA++T++FAG +A+ R+S+ + KL+++ D + RG+ +
Sbjct: 108 IYMPNSICTIATILAAARLGAIYTLIFAGLGINAIVSRISNLEPKLVISIDKTFRRGKEI 167
Query: 201 YVY 203
+Y
Sbjct: 168 KLY 170
Score = 84.6 bits (200), Expect = 8e-15
Identities = 57/182 (31%), Positives = 91/182 (50%), Gaps = 17/182 (9%)
Query: 272 EWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWI 331
E + + +PL ++YTSG+TGKPKGV+ +++ F +F D+ TADVGWI
Sbjct: 195 EKIESNEPLKIMYTSGTTGKPKGVILPHGAWMVGDYTVFDLMFSLKSDDIVLTTADVGWI 254
Query: 332 TGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNV 391
T + ++Y L + +T EG P +P DR II++ + +T+PT +R L +V
Sbjct: 255 T-FSRIMYGTLMHGSTLAFMEGAPDYPS-DRLPKIIDELQPKVLFTSPTLLRTLQ-KLDV 311
Query: 392 EDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTETGGHVITGLP 451
+ L + + + GE ++ AW Y R + D + QTE G + G P
Sbjct: 312 K--------LPRVEFIATAGEIMDETAWK-YALRFSDR---VADVYGQTELG--YVIGYP 357
Query: 452 GA 453
A
Sbjct: 358 YA 359
>UniRef50_Q397N8 Cluster: Acetoacetyl-CoA synthase; n=5;
Bacteria|Rep: Acetoacetyl-CoA synthase - Burkholderia
sp. (strain 383) (Burkholderia cepacia (strain ATCC
17760/ NCIB 9086 / R18194))
Length = 665
Score = 113 bits (273), Expect = 1e-23
Identities = 109/441 (24%), Positives = 191/441 (43%), Gaps = 41/441 (9%)
Query: 24 YKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRVF--VKFMEEAELNV 81
Y ++ S+ E + FW + +QW+ G + +T G ++ +A +N
Sbjct: 39 YDALWRWSVREPDAFWASI---WQWYGVQYDGSARR----VTDGAPMPHTRWFPDARVNY 91
Query: 82 CYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVA 141
++L G AF + + T ++ +L V + A L G+ GDRV
Sbjct: 92 AEHVLQNAAHAGAAP--AFHYASETRPLQT-MSLAELASQVRRVATRLRDLGVVPGDRVV 148
Query: 142 VYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGERMY 201
Y+P + E + MLA IGA+ + F + +R K+L+ ADG G +++
Sbjct: 149 AYLPNVPECAVAMLATTAIGAIWSSAAIDFGVRTVVDRFQQIAPKVLIAADGYHFGGKVF 208
Query: 202 VYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIWWHEV 261
+R + I +A + V + V + + SL + W +
Sbjct: 209 DRRREVAE-IARALPSLQTLVWLPNVADAMP--ADATSLPCAVHA-----------WDAL 254
Query: 262 LEGE---SNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHR 318
L G ++ E V A+ PL+++++SG+TG PK +VH AG L D H
Sbjct: 255 LAGPDVPADTFRFERVGADHPLWIVFSSGTTGLPKAIVHGHAGILAEHLKLMHLHVDLHP 314
Query: 319 RDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTA 378
DV + + GW+ + V A L A++V+++G+P + W + T F +
Sbjct: 315 GDVMFFYSTTGWMMWNLLV--ASLLTGASAVLYDGSPMHGGPECLWRLAADAGATCFGGS 372
Query: 379 PTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFW 438
PT ++ +M +E G DLS+LR + G P P + W+Y + + D +
Sbjct: 373 PTFVQ-MMEKSGIEPGR--QFDLSALRSVLLSGAPSTPETFAWFYRNVKQ------DLWV 423
Query: 439 QTETGG-HVITGLPGATPMKP 458
+++GG + +GL GA P P
Sbjct: 424 TSQSGGTELCSGLVGAVPSLP 444
Score = 70.1 bits (164), Expect = 2e-10
Identities = 57/200 (28%), Positives = 87/200 (43%), Gaps = 5/200 (2%)
Query: 504 GVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQD--RFERVYFSKFPGYYCTGD 561
G+ + N+DG + G LV +P P M D R+ YF FPG + GD
Sbjct: 456 GMAVDVWNDDGQPVVDE-VGELVVTQPAPSMPIFFWNDDGGARYRESYFETFPGVWRHGD 514
Query: 562 GVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALY 621
+R DG +I GR D LN G + +AE+ V+ V+++ VV G +
Sbjct: 515 FMRITRDGGCYIYGRADSTLNRYGVRIGSAEIYRVVEEIDEVADSLVVCCELPGGGFFMP 574
Query: 622 CFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKIAV 681
FV L+ G D L + +R PDT+ +P T +GK M +RKI +
Sbjct: 575 LFVRLRNGETLDDTLRARIAERLRTLCSPRHVPDTMVAMEQIPYTLTGKKMEVPVRKILM 634
Query: 682 GD--HEVGDISTLADPGVVE 699
G + +A+P ++
Sbjct: 635 GRPVEQAASRDAMANPAALD 654
>UniRef50_Q8G3C8 Cluster: Acetoacetyl-CoA synthase; n=36;
Proteobacteria|Rep: Acetoacetyl-CoA synthase - Brucella
suis
Length = 662
Score = 113 bits (272), Expect = 2e-23
Identities = 101/361 (27%), Positives = 164/361 (45%), Gaps = 32/361 (8%)
Query: 72 KFMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLA 131
KF EA LN NLL G G+ I F E R+T+ L LV + +L+
Sbjct: 90 KFFPEARLNFAENLLRHK---GDGEAIVFRGENKVE---RRLTWNDLHALVSKLQQFMLS 143
Query: 132 KGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTA 191
+G++ GDRVA MP + EAV MLA + IGAV + F + +R + KL
Sbjct: 144 EGVQPGDRVAGMMPNMPEAVALMLAASSIGAVWSSCSPDFGVQGVLDRFGQIEPKLFFAC 203
Query: 192 DGAW-RGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNW 250
DG W G+R+ V + + + K V +V +L + D
Sbjct: 204 DGYWYNGKRIAVADKVAE--VTAKLPGLKRAV----IVTYLGEA-------EAVAD---- 246
Query: 251 NEETDIWWHEVLEGESNICPPEWVAA--EDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAA 308
E I + LE P E+ + PL++L++SG+TG PK +VH G L+
Sbjct: 247 KAEKGIALYAALE-PFKAKPVEFTQLPFDHPLYILFSSGTTGIPKCIVHRAGGVLLQHLK 305
Query: 309 TFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIIN 368
R D D ++ GW+ + + + +A+ AT ++++G+P++P + +
Sbjct: 306 EHRLHADLRDGDRFFYFTTCGWMMWNW--LASGIASGATLMLYDGSPFYPDGNVLFDYAA 363
Query: 369 KYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGK 428
+T F T+ I A++ ++ G DLS+LR + S G P++P + + Y I K
Sbjct: 364 AEGMTYFGTSAKFIDAVL-KAGLKPGE--THDLSALRTISSTGSPLSPEGFAFVYDAIKK 420
Query: 429 E 429
+
Sbjct: 421 D 421
Score = 84.2 bits (199), Expect = 1e-14
Identities = 58/198 (29%), Positives = 93/198 (46%), Gaps = 5/198 (2%)
Query: 504 GVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQ--DRFERVYFSKFPGYYCTGD 561
G+ + N+DG + G +G LV + +P M D ++++ YF +F +C GD
Sbjct: 457 GMAVDVWNDDGKPVRGE-KGELVCTKAFPSMPLQFWNDAQGEKYQAAYFERFDNIWCHGD 515
Query: 562 GVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALY 621
E G + I GR D LN G + TAE+ + P ++EA + + + + +
Sbjct: 516 FAEWTEHGGIVIHGRSDATLNPGGVRIGTAEIYNQVEQMPEIAEALCIGQDWD-RDVRVV 574
Query: 622 CFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKIAV 681
FV L EG+ D DL + +R P I +P+T+SGKI+ +R I
Sbjct: 575 LFVRLAEGVVLDDDLKARIRTKIRTGATPRHVPAKIIAVRDIPRTKSGKIVELAVRDIVH 634
Query: 682 GDHEVGDISTLADPGVVE 699
G EV + LA+P +E
Sbjct: 635 G-REVKNREALANPEALE 651
>UniRef50_Q5KW92 Cluster: Acetyl-CoA synthetase; n=2;
Geobacillus|Rep: Acetyl-CoA synthetase - Geobacillus
kaustophilus
Length = 552
Score = 113 bits (272), Expect = 2e-23
Identities = 63/180 (35%), Positives = 95/180 (52%), Gaps = 4/180 (2%)
Query: 499 GFPFFGVEPKILNEDGVEIEGPGEGYLVF-ARPWPGMMRTLLEDQDRFERVYFSKFPGYY 557
G+P G + +L+E+G + G + F P + + +D ++ K ++
Sbjct: 366 GWPLPGFDVALLDENGTPVADGEVGQIAFNTDSIPNVFKGYWKDPEKTAERLIGK---WF 422
Query: 558 CTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKG 617
TGD +DEDGY W GR DD+++ +G+ + E+E L P V EAA V KP VKG
Sbjct: 423 LTGDLATKDEDGYFWFQGRADDIISSAGYRIGPFEIESCLLEHPAVVEAAAVGKPDPVKG 482
Query: 618 EALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILR 677
E + FVVL+EG +L + L+L V+ ++ P ++ LPKT SGKI R ILR
Sbjct: 483 EIVKAFVVLREGFAPSDELAEELSLFVKTRLSKHEYPREVEFVTELPKTPSGKIQRFILR 542
Score = 83.4 bits (197), Expect = 2e-14
Identities = 52/156 (33%), Positives = 78/156 (50%), Gaps = 8/156 (5%)
Query: 272 EWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWI 331
E +D L + YTSGSTG PKG + L+ RY DV++ AD GW
Sbjct: 187 EETTVDDLLAIQYTSGSTGMPKGAMWPH-NVLINIYPYMRYAIGLRDDDVFFGGADPGWA 245
Query: 332 TGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNV 391
G + +AP+A V +EG P+ P + +S++ KY+VT F APTA RA+ A
Sbjct: 246 YGLIFCTFAPMAFGVPIVFYEG-PFKP--ETCYSLMEKYRVTNFAYAPTAYRAMAA---- 298
Query: 392 EDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIG 427
++ ++R + S GEP+NP ++ +G
Sbjct: 299 AGADVIRRYQLNVRAMSSAGEPLNPEVIRFFQEHVG 334
Score = 69.3 bits (162), Expect = 3e-10
Identities = 39/111 (35%), Positives = 64/111 (57%), Gaps = 3/111 (2%)
Query: 80 NVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDR 139
N + + DR ++ ++IA F+E N+ + ITYR+L D Q AN G++KGDR
Sbjct: 32 NAAHEVCDRYAEDP--NRIALFYE-NALGEQKTITYRQLRDWSNQMANVFRKLGVKKGDR 88
Query: 140 VAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVT 190
V MP V+ +LA ++GAV+ +F F A+ R++ ++AK+L+T
Sbjct: 89 VCALMPKNPALVVYILAAWKVGAVYVPLFTAFGPQAIEYRINHSEAKVLLT 139
>UniRef50_A0LVM6 Cluster: Acetoacetyl-CoA synthase; n=5;
Bacteria|Rep: Acetoacetyl-CoA synthase - Acidothermus
cellulolyticus (strain ATCC 43068 / 11B)
Length = 687
Score = 113 bits (271), Expect = 2e-23
Identities = 108/418 (25%), Positives = 177/418 (42%), Gaps = 35/418 (8%)
Query: 13 IKKSYLPSIQKYKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRVFVK 72
++++Y S+ ++E S+ FW+++ W G F +
Sbjct: 64 MQEAYGTSLPDTPALHEFSIRHIGEFWSQL-----WDFCSVVGEKGDVAFVDAPDMRDAR 118
Query: 73 FMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAK 132
F EA LNV LL R+ + F E + ++ + +L V + A L A
Sbjct: 119 FFPEARLNVVDTLLRRDDDT---PALLFVREDGVRETWS---WHQLRSTVSRAAGALAAV 172
Query: 133 GIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTAD 192
GI GD VA ++P +A + LA A IGA+ T F + A+ +R K+L D
Sbjct: 173 GITAGDVVAAWLPNCPQAYVVALAAAWIGAIFTSASPEFGAPAVLDRFGQVAPKILFAVD 232
Query: 193 GAWRGERMYVYKRTCDDAIEKARTFFKHRVDMC-MVVNHLDRVTPGGSLKSEIKDLYNWN 251
G W G R C D EK + +VV H P G+ + + D
Sbjct: 233 GYWYGGR-------CFDTAEKLAAVTAELATVRNVVVIHYVHERPHGAA-ANVCD----- 279
Query: 252 EETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFR 311
W + GE P + P +VLY+SG+TG+PK +VH G L+ R
Sbjct: 280 -----WRDFLTRGEHVSIAPVRGGFDVPQYVLYSSGTTGRPKCIVHRAGGLLLTHLKEHR 334
Query: 312 YVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYK 371
D D + GW+ + + LA+ AT V+++G+P +P+ + +
Sbjct: 335 LHCDIRPGDRVFYFTTTGWMMWNW--LLGALASEATLVVYDGSPMYPEPLALFDLAADLD 392
Query: 372 VTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKE 429
+T F T+ + +L ++ G + DLS+LR + S G P+ P A+ W Y + ++
Sbjct: 393 ITLFGTSARYLDSL-RRSGLQPG--SGRDLSALRTITSTGSPLLPDAFDWVYATVKRD 447
Score = 87.0 bits (206), Expect = 2e-15
Identities = 60/198 (30%), Positives = 93/198 (46%), Gaps = 6/198 (3%)
Query: 501 PFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDR--FERVYFSKFPGYYC 558
P G+ ++++ G + G LV RP+P + D+DR + YF+ FP +
Sbjct: 480 PALGMAVDVVDDTGRPVPVGVTGELVCTRPFPSLPLGFWGDEDRRRYTEAYFAVFPDIWR 539
Query: 559 TGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKG- 617
GD + R G I+GR D LN G + TAE+ +A P++ +A + + +V G
Sbjct: 540 HGDWITRTPHGGFVISGRSDATLNPGGVRIGTAEIYRQVARFPQIMDAVAIGQ--QVDGD 597
Query: 618 EALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILR 677
E + FV L +G Q +LV + +R P I P +P+T SGKI +R
Sbjct: 598 ERIVLFVTLADGAQLTPELVDEVQTAIRVNCSPRHVPARILAVPDVPRTHSGKIAEIAVR 657
Query: 678 KIAVGDHEVGDISTLADP 695
AV V + LA+P
Sbjct: 658 D-AVHGRPVRGVEALANP 674
>UniRef50_UPI00005102FE Cluster: COG0365: Acyl-coenzyme A
synthetases/AMP-(fatty) acid ligases; n=1;
Brevibacterium linens BL2|Rep: COG0365: Acyl-coenzyme A
synthetases/AMP-(fatty) acid ligases - Brevibacterium
linens BL2
Length = 680
Score = 112 bits (269), Expect = 4e-23
Identities = 114/448 (25%), Positives = 186/448 (41%), Gaps = 34/448 (7%)
Query: 20 SIQKYKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRVF--VKFMEEA 77
S + ++Y S+T+ E FW V + F Y + + RV ++ A
Sbjct: 32 SFDGWDDLYAWSITDIEDFWESVWEYFDVK------SHSPYT-SVLEERVMPHARWFTGA 84
Query: 78 ELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKG 137
LN + L + D++A + +D+T +TY +L V + GL+ G++KG
Sbjct: 85 TLNYAEHSLGAPEQ---ADEVAVTAVSQTREDFT-LTYAELRREVARVRAGLIDLGVKKG 140
Query: 138 DRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRG 197
DRV Y+P EA++ LA A +GA+ F + ++ +R S + +L+ G G
Sbjct: 141 DRVVGYLPNQPEALVAFLAAASLGAIWASCAPEFGTQSVIDRFSQVEPTVLLAISGYMYG 200
Query: 198 ERMYVYKRTCDDAIEKARTFFKHRV-----DMCMVVNHLDRVTPGGSLKSEIKDLYNWNE 252
+ + + T H V D + + ++ T G L I D+ ++
Sbjct: 201 NKAVDRTGELTEVLAALPTL-THLVSLDYGDFTLDDDTREQFTNGAGLDHAI-DVVDYAG 258
Query: 253 ETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRY 312
S E V + PLF+L++SG+TG+PK +VH+ G L+
Sbjct: 259 LGATSAGTAGGAPSAELEFEPVPFDHPLFILFSSGTTGRPKAIVHSHGGILLETLKNHAL 318
Query: 313 VFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKV 372
FD + + W+ +T V L ++ VM +G P FP W I K
Sbjct: 319 HFDLGPGSQFCWFSTTAWMMWNTLV--GGLVVGSSIVMIDGNPNFPDPKELWRIAANTKA 376
Query: 373 TQFYTAPTAI-RALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERC 431
T AP AI A A +N + DLS++ G+ G P+ + W Y + G
Sbjct: 377 TLMGVAPGAIMSARKAGFNPTEEF----DLSAVSQFGAAGAPLPAEGYEWVYEQFGD--- 429
Query: 432 SIVDTFWQTETGG-HVITGLPGATPMKP 458
D GG V TG+ A+P+ P
Sbjct: 430 ---DVLLNVGCGGTDVCTGILQASPLTP 454
Score = 71.3 bits (167), Expect = 8e-11
Identities = 54/184 (29%), Positives = 85/184 (46%), Gaps = 7/184 (3%)
Query: 523 GYLVFARPWPGMMRTLL-EDQD-RFERVYFSKFPGYYCTGDGVRRDEDGYLWITGRIDDM 580
G LV +P P M T E+ D R+E YF K+P + GD + G + +TGR D
Sbjct: 484 GELVITQPTPSMPVTFWGENGDARYEAAYFDKYPSIWRHGDWAKFTTGGGVVVTGRSDAT 543
Query: 581 LNVSGHLMSTAEVEGVLASDPRVSEAAVV--PKPHEVKGEALYCFVVLKEGLQFDADLVK 638
LN G + TA+ VL + V++A V+ P GE L FV ++G+ F L
Sbjct: 544 LNRGGVRLGTADFYSVLDTFAEVADALVIHLEDPDGGMGE-LVLFVQTEDGMSFSDGLSD 602
Query: 639 TLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKIAVG--DHEVGDISTLADPG 696
+ ++ ++ PD + +P R+GK + +++I G V L DP
Sbjct: 603 RIRTELKSRLSPRHTPDEVVPVTRIPLGRTGKKLEVPVKRIVQGATAESVASTGALQDPW 662
Query: 697 VVEE 700
++E
Sbjct: 663 SLDE 666
>UniRef50_A0KEL2 Cluster: Acetoacetyl-CoA synthase; n=2;
Aeromonas|Rep: Acetoacetyl-CoA synthase - Aeromonas
hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB
9240)
Length = 645
Score = 111 bits (267), Expect = 6e-23
Identities = 104/410 (25%), Positives = 182/410 (44%), Gaps = 39/410 (9%)
Query: 21 IQKYKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRVFVKFMEEAELN 80
+ Y ++Y+ S+ ++ FW V Q V + G + N + ++ ++ LN
Sbjct: 34 LHSYAQLYQWSVEKTTRFWPLVWQHCG--VKGELGNIVAENRQEMQR---TRWFPDSRLN 88
Query: 81 VCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRV 140
NLL R I EG SP +++R+L D V + A L +GI +GD V
Sbjct: 89 FAENLLRRQDDT---PAIISRIEG-SPSQ--TLSWRELADQVARLAQWLRGQGIGRGDVV 142
Query: 141 AVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGERM 200
A Y+P I + V+ MLA +GA+ T F ++ ER + ++L DG
Sbjct: 143 AAYLPNIPQTVVAMLATTSLGAIWTSTSPDFGEASVVERFGQTRPRVLFAVDG------- 195
Query: 201 YVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIWWHE 260
Y Y D +K + VV +D + ++ I L + W +
Sbjct: 196 YHYNGKAIDIQDK----------VAGVVGQIDSIE-----QTVIIPLLGHPLQLGHDWRQ 240
Query: 261 VLEGESNICPP-EWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRR 319
+L + + E +A DPL++LY+SG+TGKPK +VH G L+ + D
Sbjct: 241 ILASQPDASLQFEPMAFNDPLYILYSSGTTGKPKCIVHGIGGTLLQHLKEHQLHCDIKPG 300
Query: 320 DVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAP 379
+ + GW+ + V + LA+ AT V+++G+P++P + W + +V F T+
Sbjct: 301 ERIFYFTTCGWMMWNWLV--SALASGATLVLYDGSPFYPDGNVLWDLARDEEVALFGTSA 358
Query: 380 TAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKE 429
+ AL + + L LR++ S G ++P + + Y +I ++
Sbjct: 359 KYLDAL---HKQGYAPIKTHQLPQLRLICSTGSVLSPEGFDYVYQQIKRD 405
Score = 89.0 bits (211), Expect = 4e-16
Identities = 60/205 (29%), Positives = 99/205 (48%), Gaps = 6/205 (2%)
Query: 504 GVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQ--DRFERVYFSKFPGYYCTGD 561
G+ ++ NE G ++G +G LV +P+P D D++ YF +F +C GD
Sbjct: 441 GLAVQVFNEAGQPVQGE-KGELVCTKPFPAQPIGFWGDASGDKYHAAYFERFDNIWCHGD 499
Query: 562 GVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALY 621
+ G + GR D LN G + T+E+ + V E+ V+ + + + E +
Sbjct: 500 WIELTPTGGILFYGRSDATLNPGGVRIGTSEIYRYVEQLEEVEESIVIGQQWQ-QDERVV 558
Query: 622 CFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKIAV 681
FV LK GL D L + + VR A P I +P+T+SGKI+ +R++ V
Sbjct: 559 LFVKLKPGLMLDEALRERIRQQVRLHCTARHVPARILQVDAIPRTKSGKIVELAVREV-V 617
Query: 682 GDHEVGDISTLADPGVVEELFNNRP 706
+ V + LADP V+ + + +RP
Sbjct: 618 HNRPVNNTHALADPEVLSQ-YRDRP 641
>UniRef50_UPI000038E2AC Cluster: hypothetical protein Faci_03000151;
n=1; Ferroplasma acidarmanus fer1|Rep: hypothetical
protein Faci_03000151 - Ferroplasma acidarmanus fer1
Length = 646
Score = 109 bits (262), Expect = 3e-22
Identities = 107/409 (26%), Positives = 175/409 (42%), Gaps = 46/409 (11%)
Query: 20 SIQKYKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRVFVKFMEEAEL 79
++ YKE++E S+ E+FW +A + +YN +++ V ++ E A +
Sbjct: 35 NMNSYKELWEWSVKNPEIFWISLADFSGLDLG-------EYNSILSENNVNARWFEGARV 87
Query: 80 NVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDR 139
N DR + +K A N ITY L V A + GI D
Sbjct: 88 NYA----DRVYRMRNIEKAAII-SYNEEGKEQVITYHSLWQKVSSLAAYFQSNGIAASDT 142
Query: 140 VAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAK-LLVTADGAWRGE 198
V Y+ I EAVI +LA A IGA+ + F + ER S K L+V+ + ++ G+
Sbjct: 143 VCAYIGNIPEAVITLLATASIGAIWSSCSPDFGIKGVIERFSQISPKVLIVSPEYSYNGK 202
Query: 199 RMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIWW 258
+Y RT ++AI+ + + R+ +T G EI D N D
Sbjct: 203 ---LYDRT-ENAIKILKALPEVRI----------AITTGNK---EIHDFTKMNSIPD--- 242
Query: 259 HEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHR 318
S P + V PL++LY+SG+TGKPK +VH G L+ +
Sbjct: 243 -----SRSEFVPIK-VEFSHPLWILYSSGTTGKPKAIVHGHGGILLEHLKVIMLHMNIKE 296
Query: 319 RDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTA 378
V+ GW+ + V+ L +T ++++G+ +P W + KY +T +
Sbjct: 297 NSVFTWATTTGWMMWN--VLVGGLLAGSTILLYDGSLSYPDTGILWKLSEKYGITHLGVS 354
Query: 379 PTAIRALM-AHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRI 426
I +LM + ++D L L +GS G P++P A+ + Y I
Sbjct: 355 AAYIGSLMDSRIKIKDHY----QLDKLEFIGSTGSPLSPDAFEFVYENI 399
Score = 77.8 bits (183), Expect = 9e-13
Identities = 53/181 (29%), Positives = 85/181 (46%), Gaps = 3/181 (1%)
Query: 504 GVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQD--RFERVYFSKFPGYYCTGD 561
G + L+ DG + +G L P P M D D R+ Y++ +PG + GD
Sbjct: 438 GAHVEALDPDGKPVINE-KGELAIMDPMPDMPVFFWNDPDKTRYYESYYNFYPGIWRHGD 496
Query: 562 GVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALY 621
+ D++G + I GR D +LN +G + T E+ L V ++ V+ K +
Sbjct: 497 YISIDDEGRVIIYGRSDAILNRNGIRIGTGEIYSSLNGIEMVDDSIVIGYTDSRKIYRIT 556
Query: 622 CFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKIAV 681
FVVL+ + D +L+ T+ +R + PD I AP +P T +GK M +R+I
Sbjct: 557 LFVVLRGNAKLDDNLIGTIKSKIRDDLSPRHVPDYILQAPSVPYTLNGKKMEVPVRRILE 616
Query: 682 G 682
G
Sbjct: 617 G 617
>UniRef50_Q8IWD2 Cluster: Acetoacetyl-CoA synthetase; n=53;
Eumetazoa|Rep: Acetoacetyl-CoA synthetase - Homo sapiens
(Human)
Length = 672
Score = 109 bits (262), Expect = 3e-22
Identities = 107/411 (26%), Positives = 184/411 (44%), Gaps = 37/411 (9%)
Query: 20 SIQKYKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRVFV-KFMEEAE 78
+++ Y ++Y S+ FW E +F V + + D +KG V ++ + +
Sbjct: 43 ALESYDDLYHWSVESYSDFWAEF-WKFSGIVFSRVYDEV---VDTSKGIADVPEWFKGSR 98
Query: 79 LNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGD 138
LN NLL R+ +N D++A + ++ ++T+ +L V FA + G++KGD
Sbjct: 99 LNYAENLL-RHKEN---DRVALYVAREGKEEIVKVTFEELRQEVALFAAAMRKMGVKKGD 154
Query: 139 RVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGE 198
RV Y+P AV MLA A IGA+ + F + + +R S + KL+ + +
Sbjct: 155 RVVGYLPNSEHAVEAMLAAASIGAIWSSTSPDFGVNGVLDRFSQIQPKLIFSVEAV---- 210
Query: 199 RMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIWW 258
VY + +EK + K D+ VV V P S + I DL ++
Sbjct: 211 ---VYNGKEHNHMEKLQQVVKGLPDLKKVV-----VIPYVSSRENI-DLS--KIPNSVFL 259
Query: 259 HEVL-EGESNICPP---EWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVF 314
+ L G S P E + PLF++++SG+TG PK +VH+ G L+
Sbjct: 260 DDFLATGTSEQAPQLEFEQLPFSHPLFIMFSSGTTGAPKCMVHSAGGTLIQHLKEHLLHG 319
Query: 315 DYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQ 374
+ D+ C VGW+ + V + LA A V+++G+P P + W ++++ +T
Sbjct: 320 NMTSSDILLCYTTVGWMMWNWMV--SLLATGAAMVLYDGSPLVPTPNVLWDLVDRIGITV 377
Query: 375 FYTAPTAIRAL--MAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYY 423
T + L A VE +L M L + S G P+ ++ + Y
Sbjct: 378 LVTGAKWLSVLEEKAMKPVETHSLQM-----LHTILSTGSPLKAQSYEYVY 423
Score = 84.2 bits (199), Expect = 1e-14
Identities = 52/182 (28%), Positives = 90/182 (49%), Gaps = 4/182 (2%)
Query: 504 GVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQD--RFERVYFSKFPGYYCTGD 561
G+ + NE+G + G G LV +P P D++ ++ + YFSKFPG + GD
Sbjct: 465 GMAVEAWNEEGKAVWGES-GELVCTKPIPCQPTHFWNDENGNKYRKAYFSKFPGIWAHGD 523
Query: 562 GVR-RDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEAL 620
R + G + + GR D LN +G ++E+ ++ S V ++ VP+ ++ + E +
Sbjct: 524 YCRINPKTGGIVMLGRSDGTLNPNGVRFGSSEIYNIVESFEEVEDSLCVPQYNKYREERV 583
Query: 621 YCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKIA 680
F+ + G F DLVK + +R + A P I G+P T +GK + +++I
Sbjct: 584 ILFLKMASGHAFQPDLVKRIRDAIRMGLSARHVPSLILETKGIPYTLNGKKVEVAVKQII 643
Query: 681 VG 682
G
Sbjct: 644 AG 645
>UniRef50_Q21PV0 Cluster: Bifunctional acetoacetyl-CoA
synthase/AMP-(Fatty) acid ligase; n=1; Saccharophagus
degradans 2-40|Rep: Bifunctional acetoacetyl-CoA
synthase/AMP-(Fatty) acid ligase - Saccharophagus
degradans (strain 2-40 / ATCC 43961 / DSM 17024)
Length = 646
Score = 109 bits (261), Expect = 3e-22
Identities = 111/442 (25%), Positives = 194/442 (43%), Gaps = 36/442 (8%)
Query: 13 IKKSYLPSIQKYKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRVFVK 72
+ Y I+ Y E++ S+ + FWT + F + G + N D G
Sbjct: 22 LNSRYSLGIETYPELHRFSVERAAEFWTSL---FDFFDVQYSGSLLPANTDW--GFSEYG 76
Query: 73 FMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAK 132
+ ELN NLL + G + A + S + ITY L V G+ A
Sbjct: 77 WFPNVELNFAENLLHK----GKPQQRALYGILES-GEVQSITYADLRKSVAALQAGI-AD 130
Query: 133 GIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTAD 192
I++ D +A YMP I I MLA +G V T F + + +R ++ K+L+ A
Sbjct: 131 SIKEDDVLACYMPNIPATTISMLAATGLGGVFTSTSCDFGEEGVIDRFGQSEPKVLIAAL 190
Query: 193 G-AWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWN 251
+ G+R + ++ + ++K ++ K ++V+ L+ +L + I +
Sbjct: 191 AYQYNGKRFDLTQKIA-NIVKKVKSIKK-----VILVDFLNDADQDAAL-AAIPNAQ--- 240
Query: 252 EETDIWWHEVLEGESNICPPEWVAAE--DPLFVLYTSGSTGKPKGVVHTTAGYLMYAAAT 309
W +V+ S P++V + DPL+++Y+SG+TG+PK +VHT G L+
Sbjct: 241 -----MWQQVVNTTSECETPKYVKRKFADPLYIMYSSGTTGQPKCIVHTVGGVLLQHIKE 295
Query: 310 FRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINK 369
D + + GW+ + V + L T ++EG+P P + Y ++I+K
Sbjct: 296 LGLHADVTEQKNLFFFTTCGWMMWNWLV--SGLFFGGTVTLYEGSPTKPTIIDYCALIDK 353
Query: 370 YKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKE 429
+ F T+P ++AL DG T+ +L+SL + S G P+ P + + Y I K+
Sbjct: 354 LNINIFGTSPKFLKALEGE---TDGLKTL-NLASLESILSTGSPLLPEQYDFVYQHI-KQ 408
Query: 430 RCSIVDTFWQTETGGHVITGLP 451
++ T+ G G P
Sbjct: 409 DVALASISGGTDILGCFFLGNP 430
Score = 62.5 bits (145), Expect = 4e-08
Identities = 50/200 (25%), Positives = 85/200 (42%), Gaps = 6/200 (3%)
Query: 504 GVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQD--RFERVYFSKFPGYYCTGD 561
G+ ++E+G +E EG L+ + +P L D D + YF++ + GD
Sbjct: 445 GMAVDCVDENGARVERGKEGELICRQSFPSRPLGFLNDADNQKINNAYFNQVANVWYHGD 504
Query: 562 GVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEA-L 620
+ E G I GR D LN G + T+E+ S + + + K +V G+ L
Sbjct: 505 FIAITEHGGAVIYGRSDATLNPGGVRIGTSEIYRQTESFDYIQDTVCIGK--QVDGDVDL 562
Query: 621 YCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKIA 680
Y FV + + ++Q P + + +P TRSGK M + +I
Sbjct: 563 YLFVKPMPNQTLTDGRITEIKQRIKQNTTPRHVPKRVISVVDIPYTRSGKKMELAVSRI- 621
Query: 681 VGDHEVGDISTLADPGVVEE 700
V E+ +I +A+P + E
Sbjct: 622 VNGKEITNIDAIANPECLSE 641
>UniRef50_Q11M02 Cluster: Acetoacetyl-CoA synthase; n=7;
Proteobacteria|Rep: Acetoacetyl-CoA synthase -
Mesorhizobium sp. (strain BNC1)
Length = 652
Score = 108 bits (260), Expect = 4e-22
Identities = 93/357 (26%), Positives = 162/357 (45%), Gaps = 26/357 (7%)
Query: 73 FMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAK 132
+ +A+LN NLL K+G GD I F E RI++ +L LV + A+
Sbjct: 82 YFPDAKLNFAENLL---WKSGNGDAIVFRGEDKVE---RRISWHELKALVSRLQQLFKAE 135
Query: 133 GIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTAD 192
G++ GDR+A MP + E V MLA A +GAV + F + +R + L + D
Sbjct: 136 GVKAGDRIAGMMPNMPETVAAMLAAASLGAVWSSCSPDFGVRGVLDRFGQIEPVLFIAPD 195
Query: 193 GAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNE 252
G W G + + + + + + K ++V++L GS ++ + E
Sbjct: 196 GYWYGGKAFDVGQKTAEILSALPSVRK-----ALIVDYL------GSARNAASGI----E 240
Query: 253 ETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRY 312
+ + E + PL++L++SG+TG PK +VH+ G L+ R
Sbjct: 241 RAVALDDAIAPFSAGPLTYERLPFAHPLYILFSSGTTGIPKCIVHSAGGTLLQHVKEHRL 300
Query: 313 VFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKV 372
D ++ GW+ + V LA+ AT ++++G+P++P + + ++
Sbjct: 301 HAGLADGDRFFYFTTCGWMMWNWLV--TGLASGATLLLYDGSPFYPDGNILFDFAAGERM 358
Query: 373 TQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKE 429
T F T+ I A + +E DLSS+RV+ S G P++P + + Y I K+
Sbjct: 359 TYFGTSAKFIDA-VRKAGLEPAR--THDLSSIRVISSTGSPLSPECFEFVYHSIKKD 412
Score = 80.2 bits (189), Expect = 2e-13
Identities = 64/220 (29%), Positives = 100/220 (45%), Gaps = 9/220 (4%)
Query: 490 LPNKSNRTRGFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQ--DRFER 547
LP S +G P G+ ++ ++ G +E G+G LV + +P M D +++
Sbjct: 435 LPVWSGEIQG-PGLGMAIEVWDDQGHPLES-GKGELVCTKAFPSMPIAFWNDPSGEKYRS 492
Query: 548 VYFSKFPGYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAA 607
YF +F +C GD G + I GR D LN G + TAE+ + P + EA
Sbjct: 493 AYFDRFENIWCHGDFAEWTPHGGIVIHGRSDATLNPGGVRIGTAEIYNQVEQLPEILEAI 552
Query: 608 VVPKPHEVKGEA-LYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKT 666
+ + + G+ + FV L EGL D L K + +R P I +P+T
Sbjct: 553 CIGQDWD--GDVRVVLFVRLAEGLMLDEALQKKIRDRIRTGASPRHVPAKIVAVKDIPRT 610
Query: 667 RSGKIMRRILRKIAVGDHEVGDISTLADPGVVEELFNNRP 706
+SGKI +R + G EV + LA+P + EL+ P
Sbjct: 611 KSGKITELAVRDVVHG-REVKNKEALANPEAL-ELYRELP 648
>UniRef50_Q2GPB1 Cluster: Putative uncharacterized protein; n=1;
Chaetomium globosum|Rep: Putative uncharacterized
protein - Chaetomium globosum (Soil fungus)
Length = 140
Score = 108 bits (259), Expect = 6e-22
Identities = 63/145 (43%), Positives = 83/145 (57%), Gaps = 24/145 (16%)
Query: 549 YFSKFPGYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAV 608
Y + + GYY TGDG RD +G+ WI GR+DD++N AAV
Sbjct: 4 YLNVYKGYYFTGDGAGRDHEGFYWIRGRVDDVVN-----------------------AAV 40
Query: 609 VPKPHEVKGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRS 668
V E+ G+A+ FV +K+G + L K L VR+ IG FAAP + P LPKTRS
Sbjct: 41 VGVADELTGQAVNAFVAIKDGNEASDALRKEFILQVRRSIGPFAAPKAVYIVPDLPKTRS 100
Query: 669 GKIMRRILRKIAVGDH-EVGDISTL 692
GKIMRRILRKI G+ ++GDI+T+
Sbjct: 101 GKIMRRILRKILAGEEDQLGDITTV 125
>UniRef50_Q0SJB1 Cluster: Acetoacetate--CoA ligase; n=1; Rhodococcus
sp. RHA1|Rep: Acetoacetate--CoA ligase - Rhodococcus sp.
(strain RHA1)
Length = 666
Score = 107 bits (257), Expect = 1e-21
Identities = 96/346 (27%), Positives = 150/346 (43%), Gaps = 39/346 (11%)
Query: 120 DLVCQFANGLLAK----GIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDA 175
+LV Q AN L A G++ GDR+A +P I V +LA A +GAV + F
Sbjct: 123 ELVAQVAN-LAAHFRKIGVQPGDRIAAMLPNIAPTVAAVLAAASVGAVWSCCAPDFGVKG 181
Query: 176 LAERLSDAKAKLLVTADG-AWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRV 234
L +R + + +L+ DG + G+R+ R F +D V H V
Sbjct: 182 LVDRFAQIEPTVLIGVDGYQFNGKRV------------DRRDVFATLLDQLPTVRHAVVV 229
Query: 235 TPGGSLKSEIKDLYNWNEETDIWWHEVLEGESNICPP-EWVAAEDPLFVLYTSGSTGKPK 293
G + + + +V+ G++ P E V + PL++LY+SG+TG PK
Sbjct: 230 DNLGL------PFIGEHRPSIAAYADVVVGDA--APQYEQVPFDHPLWILYSSGTTGLPK 281
Query: 294 GVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEG 353
G+VH+ G ++ A +D D + A W+ + V + A + ++G
Sbjct: 282 GIVHSHGGIVLEALKANALHYDLGPTDRVFIAASTAWVVWNMLV--DTMVTGAAIITYDG 339
Query: 354 TPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEP 413
+P + + D + I +Y T+F T A L E G T DLS LR + S G P
Sbjct: 340 SPTYGRPDHQFEICARYGATRFGTG-AAYLTLCEKAGTEPG--TAFDLSGLRSIMSTGSP 396
Query: 414 INPAAWLWYYTRIGKERCSIVDTFWQTETGG-HVITGLPGATPMKP 458
+ W W Y + D +++GG V TG GA P+ P
Sbjct: 397 LPDTTWRWIYDTVSP------DVHLGSDSGGTDVATGFIGANPLSP 436
Score = 91.1 bits (216), Expect = 9e-17
Identities = 54/184 (29%), Positives = 89/184 (48%), Gaps = 3/184 (1%)
Query: 501 PFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQD--RFERVYFSKFPGYYC 558
P+ GV+ + E G + G G +V P P M D D R+ YF +PG +
Sbjct: 445 PYLGVDVQAWTETGEAVVGE-VGEMVITAPMPSMPIYFWNDPDGNRYRDAYFEVYPGVWR 503
Query: 559 TGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGE 618
GD + + DG + GR D +N G M +A++ + + P ++EA V+ G
Sbjct: 504 HGDWITMEADGGCVVHGRSDSTINRGGVRMGSADIYQAVEALPEIAEALVIGAELPHGGY 563
Query: 619 ALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRK 678
+ FVVL++G D LV+ + +R++ PD I + P +P TR+GK + ++K
Sbjct: 564 HMPLFVVLRDGYDLDDALVEKIRTTIRREASPRHVPDEIIDVPAIPITRTGKRLEIPVKK 623
Query: 679 IAVG 682
+ G
Sbjct: 624 LIQG 627
>UniRef50_O28981 Cluster: Acetyl-CoA synthetase; n=2; Archaea|Rep:
Acetyl-CoA synthetase - Archaeoglobus fulgidus
Length = 586
Score = 107 bits (257), Expect = 1e-21
Identities = 65/194 (33%), Positives = 100/194 (51%), Gaps = 7/194 (3%)
Query: 499 GFPFFGVEPKILNEDGVEIEGPGE-GYLVFARP-WP--GMMRTLLEDQDRFERVYFSKFP 554
G P F + +++++G EI P E G++V W G+ + + D ++ +V+ K
Sbjct: 379 GRPTFMYDVTLVDDEGNEITKPNEVGHIVVRLDRWRPIGLFKEYMGDPEKTAKVFVGK-- 436
Query: 555 GYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHE 614
YY TGD DE GY W GR DD++ S + + EVE L P V+EAAVV PH
Sbjct: 437 -YYYTGDKAFFDEKGYWWFVGRADDVIKTSDYRVGPFEVESALIEHPAVAEAAVVGSPHP 495
Query: 615 VKGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRR 674
++ + + FV+L G + +L L + + + + P I+ P LPKT SGKI R
Sbjct: 496 IRYQLVKAFVILAPGYEPSRELALELFMHCKNILARYKIPRIIEFVPELPKTISGKIRRV 555
Query: 675 ILRKIAVGDHEVGD 688
LR+I + G+
Sbjct: 556 ELRQIEEEKRKKGE 569
Score = 62.1 bits (144), Expect = 5e-08
Identities = 62/214 (28%), Positives = 93/214 (43%), Gaps = 22/214 (10%)
Query: 231 LDRVTPGGSLKSEIKDLYNWNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTG 290
L V +K I D W E D E E E+ +W +D +F +TSG+TG
Sbjct: 165 LSNVGAEPKVKIVIGDRSGW-ESYDSLSKESSEAEA--AKTKW---DDIIFSFFTSGTTG 218
Query: 291 KPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVM 350
PK V HT Y + T + + D++ + GW +APL AT+
Sbjct: 219 LPKRVAHTATSYPVGHLMT-ACIINVQPGDIHHNLSAPGWAKYAWSSFFAPLNVGATATG 277
Query: 351 FEGTPYFPKV--DRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLG 408
F Y+ ++ D Y ++++KV F PTA R M ++ D S+LR +
Sbjct: 278 F----YYTRLNGDLYLQAVSEFKVNTFCAPPTAWRLFMF------ADIGKYDYSALRDVV 327
Query: 409 SVGEPINPAAWLWYYTRIGKERCSIVDTFWQTET 442
S GEP+NP + + E I D + QTE+
Sbjct: 328 SAGEPLNPELYEQWKKYTDTE---IRDFYGQTES 358
>UniRef50_O34613 Cluster: YtcI; n=53; Bacillales|Rep: YtcI -
Bacillus subtilis
Length = 531
Score = 106 bits (254), Expect = 2e-21
Identities = 67/182 (36%), Positives = 95/182 (52%), Gaps = 7/182 (3%)
Query: 499 GFPFFGVEPKILNEDGVEIEGPGE-GYLVFARPWPGMMRTLLEDQDRFERVYFSKFPG-Y 556
G P G + +I+NEDG EI PGE G + P + + +D +R + ++ G Y
Sbjct: 344 GKPTPGNQVEIINEDG-EICKPGEVGDIAVHLSTPALFKEYFKDPERMK----TQIRGDY 398
Query: 557 YCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVK 616
+ TGD R+DE+GY W R DD++ SG+ + EVE L P V E AVV P E++
Sbjct: 399 FLTGDRARKDEEGYFWFESRNDDIIISSGYTIGPFEVEDALVKHPEVKECAVVASPDEIR 458
Query: 617 GEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRIL 676
G + +VVL+ + +LVK L V+ + P I+ LPKT S KI R L
Sbjct: 459 GSIVKAYVVLQNHEKRSDELVKMLQNHVKTITAPYKYPREIEFVESLPKTASAKIRRVEL 518
Query: 677 RK 678
RK
Sbjct: 519 RK 520
Score = 91.9 bits (218), Expect = 5e-17
Identities = 70/216 (32%), Positives = 101/216 (46%), Gaps = 15/216 (6%)
Query: 253 ETDIWWHEVL--EGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATF 310
E D W +L E + + +D F+ YTSG+TG+PKGVVHT + +
Sbjct: 146 ENDAGWKNLLSIEADGSQFKTADTTRDDMAFLSYTSGTTGQPKGVVHTHGWAFAHLKTSA 205
Query: 311 RYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKY 370
D +D+ W TA GW A L + AT ++ G F K ++Y ++N+Y
Sbjct: 206 GAWLDISEKDIVWATAAPGWQKWVWSPFLAVLGSGATGFVYHGR--F-KAEKYLELLNRY 262
Query: 371 KVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKER 430
K+ F PT R LMA VE L DLS+L S GEP+N + G
Sbjct: 263 KINVFCCTPTEYR-LMA--KVE--GLKRFDLSALHSAVSAGEPLNREVIDVFQKHFG--- 314
Query: 431 CSIVDTFWQTETGGHVITGLPGATPMKPGAAEKKHP 466
+ D + QTE+ ++ G+ TP+KPG+ K P
Sbjct: 315 IKVRDGYGQTES--TLLVGVLKDTPIKPGSMGKPTP 348
Score = 47.2 bits (107), Expect = 0.002
Identities = 35/119 (29%), Positives = 54/119 (45%), Gaps = 2/119 (1%)
Query: 69 VFVKFMEEAELNVCYNLLDRNVK-NGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFAN 127
+FV E+ V YNL++ K + G K A WE S + +Y KL++ +
Sbjct: 1 MFVLKREDLIAPVQYNLVNEMEKFSAAGQKTALLWEDESGKQESW-SYEKLMEETNKIGA 59
Query: 128 GLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAK 186
L G +KGD++ V +P +LEA LA + G V + L R+ A+ K
Sbjct: 60 ALADLGFKKGDKLIVMVPRVLEAYAVYLAILKSGMVVIPCSEMLRAKDLEYRIEHAEVK 118
>UniRef50_Q1AT30 Cluster: AMP-dependent synthetase and ligase; n=1;
Rubrobacter xylanophilus DSM 9941|Rep: AMP-dependent
synthetase and ligase - Rubrobacter xylanophilus (strain
DSM 9941 / NBRC 16129)
Length = 537
Score = 106 bits (254), Expect = 2e-21
Identities = 67/200 (33%), Positives = 102/200 (51%), Gaps = 7/200 (3%)
Query: 482 DRTVMIVHLPNKSNR--TRGFPFFGVEPKILNEDGVEIEGPGE-GYLVFARPWPGMMRTL 538
+ T+++ + P + + G P G + ++++E G E PGE G + P + +
Sbjct: 334 ENTLLVGNFPGMRVKPGSMGKPSPGCDVRVIDEAGNECP-PGEIGDIALRGRIPALFKEY 392
Query: 539 LEDQDRFERVYFSKFPGYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLA 598
E + V+ + YY TGD RDEDGYLW GR DD++ +G+ + EVE L
Sbjct: 393 WEAPEETAAVFRGE---YYITGDRAYRDEDGYLWFVGRSDDVILSAGYRIGPFEVESTLI 449
Query: 599 SDPRVSEAAVVPKPHEVKGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQ 658
P V E+AVV P +G + FVVL EG + +LV+ L +++ + P I+
Sbjct: 450 EHPAVVESAVVASPDPDRGSVVKAFVVLGEGYEPSEELVRELQEFCKRQTAPYKYPRRIE 509
Query: 659 NAPGLPKTRSGKIMRRILRK 678
LPKT SGKI R LR+
Sbjct: 510 FVDELPKTTSGKIRRVELRQ 529
Score = 84.6 bits (200), Expect = 8e-15
Identities = 70/216 (32%), Positives = 96/216 (44%), Gaps = 16/216 (7%)
Query: 253 ETDIW--WHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATF 310
E D W + ++EG + E A+ D F+LYTSG+T PKGV+H T GY
Sbjct: 156 ERDGWEPFEGLVEGAPDGFSAEDTASSDNAFMLYTSGTTKNPKGVLH-THGYTHAKRVQA 214
Query: 311 RYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKY 370
RY D D WCT+ GW V P + + EG F +R +I +Y
Sbjct: 215 RYWLDLQDGDRLWCTSGTGWAKSIWNVYLGPWSWGTEILFHEGG--FDPAERV-RLIQEY 271
Query: 371 KVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKER 430
+T APT R + +E+ DLS LR S GEP+NP + G
Sbjct: 272 GITVLCQAPTEYRLMAKTRELEEA-----DLSGLRHAVSAGEPLNPPVIQRWKELHG--- 323
Query: 431 CSIVDTFWQTETGGHVITGLPGATPMKPGAAEKKHP 466
+I D + QTE ++ PG +KPG+ K P
Sbjct: 324 ITIHDGYGQTE-NTLLVGNFPGMR-VKPGSMGKPSP 357
Score = 36.3 bits (80), Expect = 2.9
Identities = 32/118 (27%), Positives = 54/118 (45%), Gaps = 5/118 (4%)
Query: 84 NLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAVY 143
+++DR + G + A W G ++ R+++ L +FA G+RKGDRV V
Sbjct: 27 DVVDRWAEEG---RPAMVWLGTGGEE-RRLSFADFARLSDRFAAAARELGVRKGDRVMVL 82
Query: 144 MPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVT-ADGAWRGERM 200
I E + A ++GAV + L R + + A +LV+ +G E+M
Sbjct: 83 TGKIPEWHAILTALLKLGAVAIPCAPQLRARDLEYRANHSGAVMLVSDGEGLEESEKM 140
>UniRef50_A0Z1E2 Cluster: Acetyl-coenzyme A synthetase; n=1; marine
gamma proteobacterium HTCC2080|Rep: Acetyl-coenzyme A
synthetase - marine gamma proteobacterium HTCC2080
Length = 547
Score = 106 bits (254), Expect = 2e-21
Identities = 63/170 (37%), Positives = 90/170 (52%), Gaps = 5/170 (2%)
Query: 509 ILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPG-YYCTGDGVRRDE 567
I+++ G E+ +G + RP P M L++ D +KF G + TGD +DE
Sbjct: 370 IVDDKGQEVVTGTKGNIAIKRPHPAMFSGYLDNPDATA----AKFIGDWMITGDLGEQDE 425
Query: 568 DGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALYCFVVLK 627
DGYLW GR DD++ SG+ + E+E L V AAV+ P E + E + FVVL
Sbjct: 426 DGYLWFHGRTDDVITSSGYRIGPTEIEDCLLKSDAVQLAAVIGVPDEQRTELVKAFVVLA 485
Query: 628 EGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILR 677
+G + + L ++L LVRQ + P I+ LP T +GKIMRR LR
Sbjct: 486 DGFEPNEILAESLKKLVRQHLAKHEVPRLIEFVDALPLTTTGKIMRRALR 535
Score = 65.7 bits (153), Expect = 4e-09
Identities = 61/218 (27%), Positives = 96/218 (44%), Gaps = 17/218 (7%)
Query: 251 NEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATF 310
N+ W + L+ +S + AED ++ YTSG+TG+PKGV+ L+ F
Sbjct: 162 NQALSFW--KALQEQSTSFINKATRAEDTAWISYTSGTTGQPKGVL-MPHRLLLGNKPLF 218
Query: 311 RYVFDY--HRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIIN 368
Y +DY + DV W AD WI G ++ + V + + + I+
Sbjct: 219 EYYYDYGPKKNDVLWSPADWAWIAGLINILLIGWYSGCRVVSTDMQGF--DAQAAFRILA 276
Query: 369 KYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGK 428
++K+T PT ++ LM + E D+ LRV+ S GE + LW R G
Sbjct: 277 QHKITVSLLTPTVLK-LMRQVDSE----AAQDI-DLRVVLSGGEAVGKELALWADDRFG- 329
Query: 429 ERCSIVDTFWQTETGGHVITGLPGATPMKPGAAEKKHP 466
+I + F QTE G + T P ++ G+ K P
Sbjct: 330 --LTISEGFGQTECNGMIGTN-PRLMEVRHGSLGKAMP 364
Score = 39.9 bits (89), Expect = 0.23
Identities = 22/67 (32%), Positives = 32/67 (47%)
Query: 124 QFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDA 183
Q AN G++ GDRV V + E I + C + G V + F DA+ RL +
Sbjct: 66 QLANLFGELGLQSGDRVLVMLTQSPECAISHIGCFKAGIVSCLASVLFGPDAVKHRLLGS 125
Query: 184 KAKLLVT 190
AK+ +T
Sbjct: 126 SAKVCIT 132
>UniRef50_Q4PHX8 Cluster: Putative uncharacterized protein; n=1;
Ustilago maydis|Rep: Putative uncharacterized protein -
Ustilago maydis (Smut fungus)
Length = 828
Score = 105 bits (253), Expect = 3e-21
Identities = 125/606 (20%), Positives = 256/606 (42%), Gaps = 32/606 (5%)
Query: 112 RITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGF 171
++T+ +L V A G++KGDR+A ++ LA +GA+++++
Sbjct: 151 KVTWGELRRRVALLAETFRRIGVKKGDRLAHVSANTSSPIVATLAANSVGAIYSLIATDA 210
Query: 172 SSDALAERLSDAKAKLLVTADGA-WRGERMYVYKRTCDDAIEKARTFFK-----HRVDMC 225
A+ RL+ + KLL T D + G+++ + R A E+ + K H +
Sbjct: 211 GPQAIYGRLAQIRPKLLFTDDAVLYNGKQVDILDRVAQVA-ERLQADGKIDSPLHFQVVI 269
Query: 226 MVVNHLDRVTPG-GSLKSEIKDLYNWNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLY 284
+ L + +P S K +++++ ++T + + L E + A+ P+ + +
Sbjct: 270 IRNTRLPKASPAWTSTKVRGLEMHDFVQQTGLSMADSLSHHF-----EQLPAQHPVQIFF 324
Query: 285 TSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLAN 344
+SG+TG+PK ++HT L+ + D D + GWI ++V L+
Sbjct: 325 SSGTTGEPKCIIHTQC-LLLNMKKEALLMLDLKPADTFLQITSCGWIMWIYHLV--ALSI 381
Query: 345 AATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMP-DLSS 403
+T+V+++G+P FP +++ K + + +P + L + V ++ +L
Sbjct: 382 GSTAVLYDGSPMFPNPQHVVKVVSHLKCSGYGASPRFLSELEKYCRVNKFSIAQQLELGR 441
Query: 404 LRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTETGGHVITGLPGATPMKPGAAEK 463
R++ S G P++ ++Y + K R + T+ G V+ G P+ +
Sbjct: 442 FRMMTSTGSPLSAKNVEFFYQQFPK-RAHLCSISGGTDMAG-VLVGPTKLLPLYGNFIQC 499
Query: 464 KHPVYYSSMDTFRPKQGWDRTVMIVHLPNKSNRTRGFPFFGVEPKILNEDGVEIEGPGEG 523
K + + Q D T P + + FP V +++ V
Sbjct: 500 KALGFDIQVWDAESGQRIDDT----GKPGELIVAKPFPTQPVSGEMVLHRTVWERLTDLS 555
Query: 524 YLVFARPWPGMMRTLLEDQDRFERV---YFSKFPG--YYCTGDGVRRDEDGY-LWITGRI 577
+++ G + Q +E+ Y+++FP + GD + +D L I GR
Sbjct: 556 WILLGDEQSGFFGPADQKQALYEKYMDSYYNRFPARKVWAQGDFIYQDRSTQGLEILGRS 615
Query: 578 DDMLNVSGHLMSTAEVEGVLASDPRVSEAAVV--PKPHEVKGEALYCFVVLKE-GLQFDA 634
D +LN SG ++E+ V+ V ++ VV +P + + E + F+ +++ +Q +
Sbjct: 616 DGVLNPSGVRFGSSEIYSVVDKFEFVGDSIVVGQRRPGKDEHERVLLFIKMRDPAVQLER 675
Query: 635 DLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKIAVGDHEVGDISTLAD 694
+ L ++ A P+ +P T +GK ++ I G+ S A+
Sbjct: 676 SHIAELNKAIKAAYSARHVPEHTFQVHDIPVTLNGKKTELAVKAIVNGNVGFKPSSATAN 735
Query: 695 PGVVEE 700
P ++E
Sbjct: 736 PQSLKE 741
>UniRef50_A0T9G0 Cluster: AMP-dependent synthetase and ligase; n=2;
Burkholderia ambifaria|Rep: AMP-dependent synthetase and
ligase - Burkholderia ambifaria MC40-6
Length = 551
Score = 105 bits (252), Expect = 4e-21
Identities = 116/409 (28%), Positives = 180/409 (44%), Gaps = 63/409 (15%)
Query: 276 AEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHT 335
A+DP + +TSG+TG+PK VH + +V DV+ + + + G
Sbjct: 189 ADDPCLIAFTSGTTGEPKATVHFHRDVMAACHCFPEHVLRPTADDVFCGSPPLAFTFGLG 248
Query: 336 YVVYAPLANAATSVMF-EGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDG 394
++ P++ A+ V+ + +P +R + +++++V+ +TAP A R+++ H
Sbjct: 249 ALLLFPISVGASVVLLPKASP-----ERLLAAVDRHRVSTLFTAPAAYRSMLDH------ 297
Query: 395 NLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTETGGHVITGLPGAT 454
L D+SSLR S GE + +W TR WQ TG H+I G+
Sbjct: 298 -LDRHDVSSLRKCVSAGEAL--PSW----TRDA----------WQERTGLHLIDGI---- 336
Query: 455 PMKPGAAEKKHPVYYSSMDTFRPKQGWDRTVMIVHLPNKSNRTRGFPFFGVEPKILNEDG 514
G+ E H ++ S+ DT K G G G +++E G
Sbjct: 337 ----GSTEMLH-IFASTGDT-GAKDG----------------AIGKAVPGYRLAVVDEHG 374
Query: 515 VEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYCTGDGVRRDEDGYLWIT 574
+ GYL A P R L D +R Y G+ TGD DEDGYL+
Sbjct: 375 QCLPPYEIGYL--AVQGPTGCRYL---NDTRQRDYVKH--GWNLTGDSAYLDEDGYLFYQ 427
Query: 575 GRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALYCFVVLKEGLQFDA 634
R DDM+ SG+ +S EVE L P ++E VV + E G + VVL+ G+
Sbjct: 428 ARADDMIISSGYTVSPGEVEQALLRHPDIAECGVVGQIDERGGTLICAHVVLRPGVDGSE 487
Query: 635 DLVKTLTLLVRQKIGAFAAPDTI-QNAPGLPKTRSGKIMRRILRKIAVG 682
L L V+ I + P I +A LP+ SGK+ R +LR+ + G
Sbjct: 488 ALTMQLQQHVKSVIAPYKCPHRIAYHACSLPRNESGKLRRAVLRQASHG 536
>UniRef50_A3VFU7 Cluster: Acetoacetyl-CoA synthase; n=1;
Rhodobacterales bacterium HTCC2654|Rep: Acetoacetyl-CoA
synthase - Rhodobacterales bacterium HTCC2654
Length = 667
Score = 105 bits (251), Expect = 5e-21
Identities = 103/443 (23%), Positives = 185/443 (41%), Gaps = 32/443 (7%)
Query: 20 SIQKYKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRVFVKFMEEAEL 79
S+ Y+E+ S+ + FW V F G + D R ++ L
Sbjct: 37 SLAGYRELQVWSVEDPAGFWRAVWDYFD---VIHEGEIEQVLTDDPMPRT--RWFTGTRL 91
Query: 80 NVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDR 139
N N+L R+ +G ++ + D I++ ++ V + A + GI GDR
Sbjct: 92 NYAENIL-RHETSGDPERPMMMHCAETRPDIAAISWAEVAGQVRKLATRMREMGIEPGDR 150
Query: 140 VAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGER 199
V YMP I E I MLA IG + + F + + +R S + KL+ G G +
Sbjct: 151 VVAYMPNIPETFIAMLATTAIGGIWSSAAPEFGAQTVIDRFSQIEPKLVFAVTGYRYGGK 210
Query: 200 MYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIWWH 259
Y + T + +++++L PG + +W E
Sbjct: 211 DYDRSGELAGILAALPT-----AERLVLLDYL----PGAGRPVFAGETLDWAEL--FTGP 259
Query: 260 EVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRR 319
+V + V ++ PL+VL++SG+TG PK + H G ++ + D H+
Sbjct: 260 DVARADFAFTR---VPSDHPLWVLFSSGTTGLPKPITHGHHGIVVEHLKKASFQLDMHKD 316
Query: 320 DVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAP 379
VY+C + GW+ +T ++ P+ + V+++G P P W I+ + VT F +P
Sbjct: 317 SVYFCYSTTGWMVWNT-LMAGPMLDGKV-VLYDGHPAHPDARLMWRIMAETGVTTFGVSP 374
Query: 380 TAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQ 439
T ++ ++ + G DLS+L + G P P W + + + D +
Sbjct: 375 TFMQ-MVRGAGIRPGEEF--DLSALETILLTGSPATPEILAWTHEAVKR------DLYAT 425
Query: 440 TETGG-HVITGLPGATPMKPGAA 461
+++GG V +G+ G + + P A
Sbjct: 426 SQSGGTEVCSGILGGSSLLPAYA 448
Score = 68.9 bits (161), Expect = 4e-10
Identities = 52/186 (27%), Positives = 86/186 (46%), Gaps = 4/186 (2%)
Query: 501 PFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQD--RFERVYFSKFPGYYC 558
P G + +E G + G G LV +P P M L D R+ YF +PG +
Sbjct: 454 PALGCDAVAFDEAGQPVVGE-VGELVIRQPMPSMPLFLWGDVGFARYTDSYFDVYPGIWR 512
Query: 559 TGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGE 618
GD VR +E G ++ GR D LN G + +AE+ + + ++++ +V + G
Sbjct: 513 HGDRVRFNERGGSYVLGRSDATLNRFGVRIGSAEIYRTMETFDEIADSLIVCIEEKDGGY 572
Query: 619 ALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRK 678
+ FV + G DA L + +R + PD I P +P T +GK M +R+
Sbjct: 573 YMPLFVQMANGSLSDA-LKAEIARRLRSERSPRHVPDEIVEVPEIPTTLTGKKMEVPVRR 631
Query: 679 IAVGDH 684
+ +G++
Sbjct: 632 MLLGEN 637
>UniRef50_Q9Z3R3 Cluster: Acetoacetyl-coenzyme A synthetase; n=7;
Proteobacteria|Rep: Acetoacetyl-coenzyme A synthetase -
Rhizobium meliloti (Sinorhizobium meliloti)
Length = 650
Score = 105 bits (251), Expect = 5e-21
Identities = 110/411 (26%), Positives = 175/411 (42%), Gaps = 41/411 (9%)
Query: 20 SIQKYKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRVFVKFMEEAEL 79
S Y ++ S++E FWT V + + V + G + D + +F EA L
Sbjct: 34 SFADYDAFHDWSVSERGAFWTAVWEHCK--VIGESGEKALVDGD---RMLDARFFPEARL 88
Query: 80 NVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDR 139
N NLL K G GD + F G Y R+T+ +L LV + L A+GI GDR
Sbjct: 89 NFAENLLR---KTGSGDALIF--RGEDKVSY-RLTWDELRALVSRLQQALRAQGIGAGDR 142
Query: 140 VAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGER 199
VA MP + E + MLA A +GA+ + F + +R KL + DG W
Sbjct: 143 VAAMMPNMPETIALMLATASVGAIWSSCSPDFGEQGVLDRFGQIAPKLFIVCDGYW---- 198
Query: 200 MYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIWWH 259
Y KR D K R K ++V + +L + E +
Sbjct: 199 -YNGKR--QDVDSKVRAVAKSLGAPTVIVPYAG---DSAALAPTV--------EGGVTLA 244
Query: 260 EVLEG-ESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHR 318
+ + G ++ E + PL++L++SG+TG PK +VH+ G L+ R+
Sbjct: 245 DFIAGFQAGPLVFERLPFGHPLYILFSSGTTGVPKCIVHSAGGTLLQHLKEHRFHCGLRD 304
Query: 319 RDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTA 378
+ + GW+ + + + LA AT +++G+P+ P + + + F T+
Sbjct: 305 GERLFYFTTCGWMMWNW--LASGLAVGATLCLYDGSPFCPDGNVLFDYAAAERFAVFGTS 362
Query: 379 PTAIRALMAHYNVEDGNLT---MPDLSSLRVLGSVGEPINPAAWLWYYTRI 426
I A V G T DLSSLR++ S G P++P + + Y I
Sbjct: 363 AKYIDA------VRKGGFTPARTHDLSSLRLMTSTGSPLSPEGFSFVYEGI 407
Score = 73.3 bits (172), Expect = 2e-11
Identities = 54/201 (26%), Positives = 88/201 (43%), Gaps = 5/201 (2%)
Query: 501 PFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQD--RFERVYFSKFPGYYC 558
P G+ + N++G + G +G LV R +P M D D ++ YF +F +C
Sbjct: 443 PGLGLAVDVWNDEGKPVRGE-KGELVCTRAFPSMPVMFWNDPDGAKYRAAYFDRFDNVWC 501
Query: 559 TGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGE 618
GD G + I GR D LN G + TAE+ + V+EA + + E
Sbjct: 502 HGDFAEWTPHGGIVIHGRSDATLNPGGVRIGTAEIYNQVEQMDEVAEALCIGQDWE-DDV 560
Query: 619 ALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRK 678
+ FV L G++ L + + +R P I +P+T+SGKI+ +R
Sbjct: 561 RVVLFVRLARGVELTEALTREIKNRIRSGASPRHVPAKIIAVADIPRTKSGKIVELAVRD 620
Query: 679 IAVGDHEVGDISTLADPGVVE 699
+ G V + LA+P ++
Sbjct: 621 VVHG-RPVKNKEALANPEALD 640
>UniRef50_A0LK08 Cluster: AMP-dependent synthetase and ligase; n=1;
Syntrophobacter fumaroxidans MPOB|Rep: AMP-dependent
synthetase and ligase - Syntrophobacter fumaroxidans
(strain DSM 10017 / MPOB)
Length = 549
Score = 103 bits (247), Expect = 2e-20
Identities = 61/181 (33%), Positives = 95/181 (52%), Gaps = 3/181 (1%)
Query: 499 GFPFFGVEPKILNEDGVEIEGPGE-GYLVFARPWPGMM-RTLLEDQDRFERVYFSKFPGY 556
G P GV ++LN G + + PGE G L+ P G+ R +E+Q + G+
Sbjct: 366 GKPLPGVLVRVLNAWGGDCK-PGEIGSLMLKGPSGGLYWRPFIENQRLLDAQMKGVVNGW 424
Query: 557 YCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVK 616
GD V RD+DG ++ R DD++ SG+ + AE+E +A P V++ V+ PH K
Sbjct: 425 NQMGDAVYRDDDGNIFFVSREDDIIKSSGYRIGPAEIEEAIARHPGVADVGVIGVPHPDK 484
Query: 617 GEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRIL 676
G+ F+ LK G + D D + L ++ I + P I+ P LP+T +GK++RR L
Sbjct: 485 GQVTKAFIALKPGFKGDDDFSEELREFLKDIIAIYKMPRIIEYVPSLPRTPTGKLLRRKL 544
Query: 677 R 677
R
Sbjct: 545 R 545
Score = 83.4 bits (197), Expect = 2e-14
Identities = 90/338 (26%), Positives = 150/338 (44%), Gaps = 46/338 (13%)
Query: 78 ELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKG 137
ELN+ LLDR+V++G GD+ A + ITY +L LV +F + L G+
Sbjct: 30 ELNLADYLLDRHVRDGRGDRPAVKFVDQV------ITYSELQRLVNRFGSSLRDAGLEAR 83
Query: 138 DRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRG 197
DRV + + EA+I +LA ++GA+ ++++ +A ++A K
Sbjct: 84 DRVGIRLVNCPEAIISVLAVEKLGAIPVPTSPLWAAEEIAYVANNAMMKF---------- 133
Query: 198 ERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIW 257
Y+ A+E AR+ F + +V + D V G L ++ T+
Sbjct: 134 ---YIVSAPLMGAVENARSRFTSDTRVIVVGGNRDDVRRAGHL--------SFQGMTE-- 180
Query: 258 WHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYH 317
EG S + + ED +LYTSG+TG PKG VH ++ R+V+
Sbjct: 181 -----EGSSELAAV-MLDGEDIGLILYTSGTTGMPKGCVHFVRQTIIETRVVNRFVYGLT 234
Query: 318 RRDVYWCTADVGWITGH-TYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFY 376
RDV A V + G T+ + + AA S++ +P I K+++T
Sbjct: 235 PRDVLGGAAPVSFAAGFGTFTLISFEGGAAVSLLPRFSP-----QEMMETITKHRITVLT 289
Query: 377 TAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPI 414
PTA RAL+ + + D+SS+R+ + G+ +
Sbjct: 290 GLPTAYRALLKY-----PDFKRHDISSVRLFTTGGDSL 322
>UniRef50_A6W2Z8 Cluster: Acetoacetyl-CoA synthase; n=1; Marinomonas
sp. MWYL1|Rep: Acetoacetyl-CoA synthase - Marinomonas
sp. MWYL1
Length = 646
Score = 103 bits (246), Expect = 2e-20
Identities = 112/413 (27%), Positives = 179/413 (43%), Gaps = 46/413 (11%)
Query: 24 YKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRVFVKFMEEAELNVCY 83
Y ++ S+++ + FW++V +F + K N + +F A LN+
Sbjct: 32 YDALHRWSISDLDGFWSQV-WDFAGVIGEKGSDIFVSNAE--HWMTESQFFPSARLNLAE 88
Query: 84 NLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAVY 143
NLL + G + E N D + ++ V + A GL G+ GDRVAV
Sbjct: 89 NLLKQT---GSAPCVI---ETNESGDRQVYSADEVRAEVARVAQGLRQAGVEPGDRVAVV 142
Query: 144 MPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGERMYVY 203
MP ++ LA +G V T F +A+ +R+ KLL E + Y
Sbjct: 143 MPNKFSCLVTHLATLAVGGVWTSCSPDFGVEAIIDRIGQVTPKLLFV-------EPTFQY 195
Query: 204 KRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIWWHEVLE 263
D I ++ R++ V L V P SLKS+ K + +W++
Sbjct: 196 AGKQHD-ISQSALLLAQRIES---VEQLVIVGPH-SLKSQDK-VTHWSD---------FG 240
Query: 264 GESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRD-VY 322
E+N+ V +DP ++LYTSG+TG PK +VH T G L+ D + D V
Sbjct: 241 NEANLEFTR-VGFDDPAYILYTSGTTGVPKAIVHRTGGVLLQQLKEHLLHNDVRKGDRVL 299
Query: 323 WCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPK---VD--RYWSIINKYKVTQFYT 377
W T + W+ H V A L A V+++G P + +D W ++ + ++T
Sbjct: 300 WYT-NTAWMMYHWIV--AALGCDAVLVLYDGAPILKQQVGLDCAPLWRVVEQEQLTHLGI 356
Query: 378 APTAIRALM-AHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKE 429
+P + L A + + + DLSSLR L S G P+ P + W Y+ I K+
Sbjct: 357 SPKYLGTLAEAEFEPQQHH----DLSSLRWLLSAGSPVAPNQYDWIYSAISKQ 405
Score = 61.7 bits (143), Expect = 7e-08
Identities = 47/202 (23%), Positives = 88/202 (43%), Gaps = 5/202 (2%)
Query: 504 GVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQD--RFERVYFSKFPGYYCTGD 561
G+ +L++ G + G +G LV P+P M + + R+++ YFS + GD
Sbjct: 441 GMAINVLDDRGAPVMGR-QGNLVCTEPFPSMPLSFWGEDGFARYKKTYFSDRDEIWVHGD 499
Query: 562 GVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALY 621
+ + DG I GR D+ LN G + TA++ + + V +P E +
Sbjct: 500 HAQMNSDGTAVIYGRSDNTLNPGGVRIGTADIYNACEGIKEIEDCVVFGRPIAGDEEIVL 559
Query: 622 CFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKIAV 681
C + L+E + L + + +R P I +P T +GK + + +
Sbjct: 560 C-IQLREDVTAHDGLAQRIRKSIRMACSPRHVPAAIYLVDDVPYTLNGKRVEGAAQSSLL 618
Query: 682 GDHEVGDISTLADPGVVEELFN 703
G V ++++L +P +E+ N
Sbjct: 619 G-KPVNNVASLQNPQCLEQYRN 639
>UniRef50_A0QZD4 Cluster: Acetyl-coenzyme A synthetase; n=3;
Corynebacterineae|Rep: Acetyl-coenzyme A synthetase -
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Length = 543
Score = 103 bits (246), Expect = 2e-20
Identities = 53/123 (43%), Positives = 74/123 (60%)
Query: 556 YYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEV 615
+Y TGD D++G GR DD++ ++G+ + +VE VL P V EAAVV +P +
Sbjct: 418 WYLTGDIGHVDDEGKFHFCGRDDDVIIMAGYRIGPFDVESVLVMHPSVIEAAVVARPDHL 477
Query: 616 KGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRI 675
+GE L FVVL+EG + DL K L LV++K A A P T+ LPKT SGK+ R +
Sbjct: 478 RGEVLEAFVVLREGTEGSEDLEKELQTLVKKKYAAHAYPRTVHFVTELPKTSSGKVQRHL 537
Query: 676 LRK 678
LR+
Sbjct: 538 LRR 540
Score = 102 bits (244), Expect = 4e-20
Identities = 95/331 (28%), Positives = 135/331 (40%), Gaps = 42/331 (12%)
Query: 113 ITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFS 172
+TY +L + +FA L GI GD VA M E V+ +L R GA+H +F F+
Sbjct: 50 LTYGQLREQSTKFAAALSELGIGPGDHVATLMGKSAELVVALLGIWRRGAIHVPLFTAFA 109
Query: 173 SDALAERLSDAKAKLLVTADGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLD 232
A+ RL + A+ LV D ++K T DD+ + RV
Sbjct: 110 PPAITHRLRASDAR-LVICDAD------QLHKITHDDSAPSPAPW---RV---------- 149
Query: 233 RVTPGGSLKSEIKDLYNWNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKP 292
V G S ++ +L D G S L L+TSG+TG P
Sbjct: 150 -VVAGPSTTDDVLELAGLIRRHD--------GVSTAEMTAVTGGSGTLVELFTSGTTGSP 200
Query: 293 KGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFE 352
KGV + A + D R DV+W AD GW G Y + +PLA S++
Sbjct: 201 KGVAVPLRALASFHAYQ-EFGLDVRREDVFWNAADPGWAYGLYYAILSPLATGTRSILLH 259
Query: 353 GTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGE 412
P V W ++ ++ VT F APT R+L+ ++P LR S GE
Sbjct: 260 AGFSPPLV---WRVMERFGVTNFTAAPTVYRSLLT------DPTSVPPTVRLRRASSAGE 310
Query: 413 PINPAAWLWYYTRIGKERCSIVDTFWQTETG 443
P+ P W +G + D + QTE G
Sbjct: 311 PLTPDVISWSRANLG---VLVRDHYGQTEHG 338
>UniRef50_A5WDS3 Cluster: AMP-dependent synthetase and ligase; n=5;
Gammaproteobacteria|Rep: AMP-dependent synthetase and
ligase - Psychrobacter sp. PRwf-1
Length = 554
Score = 102 bits (245), Expect = 3e-20
Identities = 50/126 (39%), Positives = 73/126 (57%)
Query: 553 FPGYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKP 612
F YY TGD V R +DG W GR DD++ +G+ + +VE + V+E+A V P
Sbjct: 427 FDDYYLTGDVVERHQDGTFWFAGRDDDIIITAGYRIGPTDVENCVMEHEAVAESAAVGVP 486
Query: 613 HEVKGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIM 672
E +G + +VVLKEG+ DLV + LV++++ A A P ++ LPKT SGKI
Sbjct: 487 DETRGHVIKSYVVLKEGIDGSEDLVNQIKSLVQKRLSAHAYPRYVEFVTALPKTPSGKIQ 546
Query: 673 RRILRK 678
R +LR+
Sbjct: 547 RFLLRQ 552
Score = 82.6 bits (195), Expect = 3e-14
Identities = 58/182 (31%), Positives = 83/182 (45%), Gaps = 13/182 (7%)
Query: 263 EGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVY 322
E S +C P + + P ++TSG+ GK KGV A + RY D + D Y
Sbjct: 189 EQYSEVCEPVLLTPDAPFLQMFTSGTVGKSKGVSVPLAALPTFYLY-MRYAIDLQQTDHY 247
Query: 323 WCTADVGWITGHTYVVYAPLANAATSVMFE-GTPYFPKVDRYWSIINKYKVTQFYTAPTA 381
W AD GW G Y + PL T+ E G +D + ++K++ ++PTA
Sbjct: 248 WNMADPGWAYGLYYAITGPLLMGITTYFNEMGFDAQNTLD----FLVRHKISNIASSPTA 303
Query: 382 IRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTE 441
R +M V +G + D SLRV S GE +N W +G C + D + QTE
Sbjct: 304 FR-MMKSSGVFEG---VADQLSLRVANSAGETLNTEVVGWVSENLG---CKVCDQYGQTE 356
Query: 442 TG 443
TG
Sbjct: 357 TG 358
Score = 76.2 bits (179), Expect = 3e-12
Identities = 45/128 (35%), Positives = 73/128 (57%), Gaps = 3/128 (2%)
Query: 63 DITKGRVFVKFMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLV 122
D+ K ++F E+A LN R+V+NG GDK+A E ++ T++++ +L
Sbjct: 25 DLLK-QIFQDHPEDA-LNAYLACCGRHVRNGLGDKVALVHE-DTKQKITQLSFNELDQRS 81
Query: 123 CQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSD 182
Q AN L A G++ GDRVA +P E +I +LA R+GA++ +F F +++A RL
Sbjct: 82 AQVANLLKAYGVKAGDRVATMLPRTPELLIVVLATWRVGAIYQPLFTAFGVESIAYRLDK 141
Query: 183 AKAKLLVT 190
A K++ T
Sbjct: 142 ADTKVVFT 149
>UniRef50_A1ID66 Cluster: Acetyl-coenzyme A synthetase; n=1;
Candidatus Desulfococcus oleovorans Hxd3|Rep:
Acetyl-coenzyme A synthetase - Candidatus Desulfococcus
oleovorans Hxd3
Length = 576
Score = 102 bits (244), Expect = 4e-20
Identities = 69/197 (35%), Positives = 94/197 (47%), Gaps = 11/197 (5%)
Query: 271 PEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYL-MYAAATFRYVFDYHRRDVYWCTADVG 329
P V L+V+YTSGST PKG++H + +YA+A ++V D DV W AD
Sbjct: 200 PRLVTPGTALYVVYTSGSTRPPKGIIHGHGDMVGIYASA--KWVLDLKADDVLWTDADPA 257
Query: 330 WITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHY 389
W+TG Y AP SV+ E V+ Y + +VT +YT P IR LM
Sbjct: 258 WVTGTVYAALAPWLCGVASVVSEAPAPSSAVNAY-RTLEACRVTVWYTTPNTIRGLMEAG 316
Query: 390 NVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTETGGHVITG 449
G +L +LR + +VG P+ P + W +G S D +W +ETG I
Sbjct: 317 EDLPGRY---NLDALRHIVTVGAPLMPDPFYWVRKHLG---LSPHDNWWMSETGMICIAN 370
Query: 450 LPGATPMKPGAAEKKHP 466
LP +KPGA K P
Sbjct: 371 LP-CLDIKPGAIGKPLP 386
Score = 95.5 bits (227), Expect = 4e-18
Identities = 58/187 (31%), Positives = 94/187 (50%), Gaps = 6/187 (3%)
Query: 499 GFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYC 558
G P G+E +L++ G E+ G L WP MM L D+ R+E +F ++
Sbjct: 382 GKPLPGIEAAVLDDSGWELPALSIGQLALKSGWPAMMVGLWGDRARYEG-HFQN--NWFL 438
Query: 559 TGDGVRRDEDGYLWITGRIDDMLNV-SGHLMSTAEVEGVLASDPRVSEAAVVPK--PHEV 615
TGD +DE+GY + GR+DD+L + E+E L P V+EAAV+ + +
Sbjct: 439 TGDIALQDEEGYFYHQGRLDDILKTRENRAIGPFEIEQALCGHPAVAEAAVIARGGDRDT 498
Query: 616 KGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRI 675
++ FV LK G + L + + + ++ + D I LP+TR+GK++RR+
Sbjct: 499 GTSSIKAFVTLKPGNPASSRLNREIRMFLKAGVAPDIDVDEITFTEKLPRTRNGKLLRRV 558
Query: 676 LRKIAVG 682
LR +G
Sbjct: 559 LRAWELG 565
Score = 50.0 bits (114), Expect = 2e-04
Identities = 30/99 (30%), Positives = 44/99 (44%), Gaps = 3/99 (3%)
Query: 95 GDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICM 154
G F +G D YT + R D+ ++A + G+ GD + +++P M
Sbjct: 60 GQPAMIFHKGGHTDIYTFLQMR---DISARWAGFFVKNGLEAGDCLMIFLPPCRAFFFAM 116
Query: 155 LACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADG 193
ACAR G V VFA L RL+D K ++T G
Sbjct: 117 AACARAGIVFCPVFASSGYSELESRLADIAPKAVLTDPG 155
>UniRef50_Q5KZW6 Cluster: Acetoacetyl-CoA synthetase; n=20;
Bacteria|Rep: Acetoacetyl-CoA synthetase - Geobacillus
kaustophilus
Length = 667
Score = 101 bits (241), Expect = 9e-20
Identities = 82/328 (25%), Positives = 144/328 (43%), Gaps = 36/328 (10%)
Query: 110 YTRITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFA 169
Y +++++L + A L A G+++GDRV YMP I E V+ LACA IGA+ +
Sbjct: 122 YREVSWQELGEKTAAIAKALRAMGVKRGDRVVAYMPNIPETVMAFLACASIGAIWSSCSP 181
Query: 170 GFSSDALAERLSDAKAKLLVTADGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVN 229
F + ++ +R + + +L DG + + D VV+
Sbjct: 182 DFGAGSVIDRFAQIEPTVLFAVDGCQYNGKEF---------------------DKMPVVS 220
Query: 230 HLDRVTPGGSLKSEIKDLYNWN------EETDIWWHEVLEGESNICPPEWVAAEDPLFVL 283
L P SLK + Y W +E + W +V+ ++ + + V + PL++L
Sbjct: 221 ELRAKLP--SLKKTVLLPY-WRGQMEAPDEGVVLWDDVVADKAELVYED-VPFDHPLWIL 276
Query: 284 YTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLA 343
Y+SG+TG PK +V G L+ + + ++ GW+ + ++V LA
Sbjct: 277 YSSGTTGLPKPIVQGHGGILLEHLKALTISENLTKDSTFFWFTTTGWMMWN-FLVGGLLA 335
Query: 344 NAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSS 403
+T V+++G+P +P + W + K +T F T+ I M + DLS
Sbjct: 336 -GSTIVLYDGSPTYPDGNVLWELAEKAGITHFGTSAAFINICM---KLGLKPKEQYDLSK 391
Query: 404 LRVLGSVGEPINPAAWLWYYTRIGKERC 431
L + S G P+ + W Y + + C
Sbjct: 392 LEAVLSTGSPLTVEGFAWVYENVKDDIC 419
Score = 87.0 bits (206), Expect = 2e-15
Identities = 56/181 (30%), Positives = 86/181 (47%), Gaps = 3/181 (1%)
Query: 504 GVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQD--RFERVYFSKFPGYYCTGD 561
G + + +E+G + G LV +P P M D D R+ YF +PG + GD
Sbjct: 453 GADVQAFDENGRPLVNE-VGELVITKPMPSMPLFFWNDPDGERYRNSYFDTYPGVWKHGD 511
Query: 562 GVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALY 621
++ DE G I GR D +N +G M T+E+ + + V E+ +V K +
Sbjct: 512 WIKIDEQGGCVIYGRSDSTINRAGVRMGTSEIYRAVEAVDGVFESLIVDLEMMGKQSFMP 571
Query: 622 CFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKIAV 681
FVVLK G D +L + + +RQ + PD I +PKT +GK M +RK+ +
Sbjct: 572 LFVVLKPGAVLDDELKERIRQSIRQHVSPRFVPDEIYEVKQIPKTLNGKKMEIPIRKLLL 631
Query: 682 G 682
G
Sbjct: 632 G 632
>UniRef50_Q2J785 Cluster: Acetoacetyl-CoA synthase; n=5;
Actinobacteria (class)|Rep: Acetoacetyl-CoA synthase -
Frankia sp. (strain CcI3)
Length = 709
Score = 100 bits (239), Expect = 2e-19
Identities = 92/352 (26%), Positives = 157/352 (44%), Gaps = 30/352 (8%)
Query: 113 ITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFS 172
+++ +L V + A GL + G+ +GDRV +P + A++ MLA A IGAV +
Sbjct: 142 VSWDELRRQVAKAAAGLRSLGVAEGDRVCAVLPNTVYAMVGMLATASIGAVWSSCSPELG 201
Query: 173 SDALAERLSDAKAKLLVTADGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLD 232
AL R K+L+ DG G + Y DA++ + V +
Sbjct: 202 PTALRARFGQIDPKVLIGVDGYSYGGKSY-------DALDTLAALAGDLPGLGASVI-VP 253
Query: 233 RVTPGGSLKSEIKDLYNWNEETDIWWHEVLEGESNICPPEW--VAAEDPLFVLYTSGSTG 290
+ P ++ L + W E++ E++ PE+ VA + PL++LY+SG+TG
Sbjct: 254 YLWPDALSRARAAGLPGL-----LTWDELMASETS--EPEFTRVAFDAPLWILYSSGTTG 306
Query: 291 KPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVM 350
PK +VH G L+ + D D + GW+ + Y+V + L AT V+
Sbjct: 307 PPKAIVHGHGGILLEHLKSLALHLDLGPDDRFCWFTTTGWMMWN-YLV-SGLLVGATVVL 364
Query: 351 FEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLT---MPDLSSLRVL 407
++G P +P + + + ++T T+ ++A ED L DLS LR +
Sbjct: 365 YDGAPGYPALGTLFGLAEALELTCLGTSVGYLQA------CEDAGLVPREFADLSRLRTV 418
Query: 408 GSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTETGGHVITGLPGATPMKPG 459
GS G P++ A + W Y + + T+ ++ GLP P++ G
Sbjct: 419 GSTGSPLSAAGYAWVYEAV-SPTVMLSSISGGTDVCTALVAGLP-TMPVRAG 468
Score = 70.1 bits (164), Expect = 2e-10
Identities = 60/218 (27%), Positives = 95/218 (43%), Gaps = 8/218 (3%)
Query: 484 TVMIVHLPNKSNRTR--GFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLED 541
T ++ LP R G G ++ +E G E+ G LV P P M D
Sbjct: 454 TALVAGLPTMPVRAGEIGSRALGCAVRVFDEAGEEVVDE-VGELVVTAPMPSMPLCFWAD 512
Query: 542 QD--RFERVYFSKFPGYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLAS 599
D R YFS +PG + GD R G + I GR D LN G + T+E+ V+
Sbjct: 513 PDGGRLRESYFSVYPGVWRHGDWARITPTGAVVIQGRSDATLNRGGVRIGTSELYSVVER 572
Query: 600 DPRVSEAAVVPKPHEVKGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQN 659
P ++++ V E L FVVL E +A + L ++R ++ PD I
Sbjct: 573 VPGIADSLAVDTADERGHGELLLFVVLTEPGLTEA-VAARLREVLRAELSPRHVPDRIIE 631
Query: 660 APGLPKTRSGKIMRRILRKIAVGD--HEVGDISTLADP 695
+P+T +GK + ++++ G E + ++A+P
Sbjct: 632 ITEVPRTHTGKKLEVPVKRLLAGTALDEAVSLDSVANP 669
>UniRef50_Q1ATG8 Cluster: AMP-dependent synthetase and ligase; n=1;
Rubrobacter xylanophilus DSM 9941|Rep: AMP-dependent
synthetase and ligase - Rubrobacter xylanophilus (strain
DSM 9941 / NBRC 16129)
Length = 561
Score = 99 bits (238), Expect = 2e-19
Identities = 65/183 (35%), Positives = 95/183 (51%), Gaps = 8/183 (4%)
Query: 499 GFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYC 558
G P G E ++++ + E P FA P + R + ER + GY+
Sbjct: 379 GVPVPGCEARLVSLEDPSEEVPVGEQGEFAARGPMIFREYWNKPEETERAFHE---GYFL 435
Query: 559 TGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGE 618
TGD D++G+ +I R DM+NVSG+ + EVE VL + P V EAAVV P +GE
Sbjct: 436 TGDVAVMDQEGWFYIVDRKKDMINVSGYKVWPREVEDVLYTHPAVKEAAVVGAPDPYRGE 495
Query: 619 ALYCFVVLKEGLQF-DADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILR 677
+ FV LKEG + + DLV R+++ A+ P I+ +PKT +GK +RR LR
Sbjct: 496 TVVAFVALKEGQRIPEEDLVS----YCRERMAAYKYPRRIEFLEEVPKTATGKFLRRELR 551
Query: 678 KIA 680
+ A
Sbjct: 552 ERA 554
Score = 70.1 bits (164), Expect = 2e-10
Identities = 86/306 (28%), Positives = 131/306 (42%), Gaps = 26/306 (8%)
Query: 113 ITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFS 172
I+Y +L DL +FA L+ +G+ KGDRVA++ + +I + GA+ + F
Sbjct: 52 ISYARLEDLASRFAAALVERGVGKGDRVAIFTQNNPQFLIAQYGAWKRGAIAVPLNPMFK 111
Query: 173 SDALAERLSDAKAKLLVTADGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLD 232
L L+D+ AK LV +G +Y+ + + RV+ + LD
Sbjct: 112 HRELDYHLNDSGAKALVCLEG--------LYREVAGEVVPGT------RVEHVFTTSELD 157
Query: 233 RVTPGGSLKSEIKDLYNWNEETDIWWHEVLE-GESNICPPEWVAAEDPLFVLYTSGSTGK 291
+ P G+ + + E EVLE + E V+ ED +++YTSG+TG
Sbjct: 158 -LLPEGAGYANLAGARKLRPEGTEDLLEVLETTPPDGGARERVSPEDIAYLVYTSGTTGP 216
Query: 292 PKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMF 351
PKG V T + + Y A +R D A + ITG V + LA A +
Sbjct: 217 PKGAVETHSN-VAYNAEVYRTWMRMGDEDSVLGVAPLFHITG--LVGHGALAALAGIPLV 273
Query: 352 EGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVG 411
+ P +I K++ T + T ALM N D DLSSL+ S G
Sbjct: 274 LFHRFDP--SEALRLIEKWRPTMTVGSITVFIALM---NAPDA--AGRDLSSLKKCYSGG 326
Query: 412 EPINPA 417
PI P+
Sbjct: 327 APIAPS 332
>UniRef50_Q0RL74 Cluster: Putative long-chain-fatty-acid CoA ligase;
n=1; Frankia alni ACN14a|Rep: Putative
long-chain-fatty-acid CoA ligase - Frankia alni (strain
ACN14a)
Length = 566
Score = 99 bits (238), Expect = 2e-19
Identities = 149/582 (25%), Positives = 230/582 (39%), Gaps = 65/582 (11%)
Query: 108 DDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVV 167
D +T +T+ +L Q A L +G+ GDRVA + + A++GAV V
Sbjct: 26 DGHT-VTFAQLDARSNQVAQALAGEGVGAGDRVAYLDANAAQYYELLFGGAKLGAVSVAV 84
Query: 168 FAGFSSDALAERLSDAKAKLLVTADGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMV 227
+ +A ++DA+A++LV GA + T + A+E K + V
Sbjct: 85 SWRLAPVEIAAIIADAQARVLVV--GA-------AFAATVE-AVEAELPGVKKII----V 130
Query: 228 VNHLDRVTPGGSLKSEIKDLYNWNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSG 287
V R ++ ++ +++ D W ++ I P +D LYTSG
Sbjct: 131 VGGSTRHEGDDEVRHQVD-----HQDYDEW----VDAAPAIDPGLCAKPDDVRIQLYTSG 181
Query: 288 STGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAAT 347
+TG PKGV+ T L D V + I+G Y + A T
Sbjct: 182 TTGLPKGVMLTEHNLLSLLRMAGE-TLDLGPDSVNLVAMPLFHISGSGYSLSGFHAGCHT 240
Query: 348 SVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVL 407
++ E P D + ++ VT + P +R ++ + + DLSSLR +
Sbjct: 241 VLLREAHP-----DTILRSVVEHGVTNLFAVPAVLRTMLGVAGIAE-----LDLSSLRTI 290
Query: 408 GSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTETGGHVIT--------GLPGATPMKPG 459
PI+ A + I RC V + +ET G V L A G
Sbjct: 291 AYGASPISLAVLV---RAIETFRCDFVQVYGLSETAGTVTMLTPEDHRRALETAGTGAGG 347
Query: 460 AAEKKHPVYYSSMDTFRPKQGWDRTVMIVHLPNKSNRTRGFPFFGVEPKILN-EDGVEIE 518
AE + D G DR V + R+ G G +I+ G + E
Sbjct: 348 TAEVAGALGALGADK---AVGADREVATAGAAGRL-RSAGRAVPGARVRIVPPHTGADAE 403
Query: 519 GPGE-GYLVFARPW--PGMMRTLLEDQDRFERVYFSKFPGYYCTGDGVRRDEDGYLWITG 575
PGE G + P PG E E G+ TGD DEDGYL+I
Sbjct: 404 -PGEVGEIWIHSPQNTPGYWHNPRETAALLE-------DGWVRTGDAGYLDEDGYLFIHD 455
Query: 576 RIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALYCFVVLKEGLQFDAD 635
R+ DM+ + AEVE VL S P +++ AV+ P E GE + VV + G
Sbjct: 456 RVKDMIITGAENVYPAEVENVLMSHPDIADVAVIGVPSERWGETVKAVVVAEAG---RTP 512
Query: 636 LVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILR 677
+ + R ++ A+ P +I LP+ +GK+++R LR
Sbjct: 513 TTEDVVSFARARLAAYKCPTSIDLVDALPRNAAGKVLKRELR 554
>UniRef50_Q97WS5 Cluster: Acetyl-CoA synthetase; n=4;
Sulfolobus|Rep: Acetyl-CoA synthetase - Sulfolobus
solfataricus
Length = 498
Score = 99.1 bits (236), Expect = 4e-19
Identities = 50/123 (40%), Positives = 68/123 (55%)
Query: 556 YYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEV 615
+Y TGD +DE+GYLW GR DD++ VSG+ + EVE VL P V E+AVV +
Sbjct: 375 WYLTGDNAYKDEEGYLWFVGRKDDVVKVSGYRIGPFEVESVLLEFPAVLESAVVADEDPI 434
Query: 616 KGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRI 675
+G L+ ++VLK G +L K + V K + + LPKT SGKI R +
Sbjct: 435 RGHVLHAYIVLKSGYTPSEELKKEIIDFVNTKYSRHVHLERVDFVDKLPKTESGKIQRYL 494
Query: 676 LRK 678
LRK
Sbjct: 495 LRK 497
Score = 79.0 bits (186), Expect = 4e-13
Identities = 60/192 (31%), Positives = 84/192 (43%), Gaps = 14/192 (7%)
Query: 277 EDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTY 336
+D + +LYTSG+TG PKG + +L +Y DV+W AD GW G Y
Sbjct: 160 DDAIILLYTSGTTGTPKGALIAKRLFLNIYVY-MKYGIGVRENDVFWNPADPGWAYGLYY 218
Query: 337 VVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNL 396
+ PL T ++F P+ P +R + + KVT F APTA R + G +
Sbjct: 219 GIIGPLMFGKT-IIFLDEPFNP--ERTMEFMEENKVTNFAFAPTAYRMIA-------GTV 268
Query: 397 TMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTETGGHVITGLPGATPM 456
L S GEP+NP W+ + K +I D + QTE G V G +
Sbjct: 269 KKKYDLVLERASSAGEPLNPEVIRWF---MDKYNVTIKDHYGQTEVGMVVYNGWGYDAKV 325
Query: 457 KPGAAEKKHPVY 468
K G+ P Y
Sbjct: 326 KIGSMGLPAPGY 337
Score = 41.5 bits (93), Expect = 0.076
Identities = 18/59 (30%), Positives = 32/59 (54%)
Query: 134 IRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTAD 192
I+KGD +A+ ++ +I LA +GA++ +F F +A+ R D K K++ D
Sbjct: 69 IKKGDVIAILASKKIQQIIVFLATLSLGAIYQPLFTAFGPEAIKMRTRDVKPKIIFCQD 127
>UniRef50_Q9KZN9 Cluster: Acetoacetyl-CoA synthetase; n=5;
Actinobacteria (class)|Rep: Acetoacetyl-CoA synthetase -
Streptomyces coelicolor
Length = 658
Score = 98.7 bits (235), Expect = 5e-19
Identities = 90/347 (25%), Positives = 148/347 (42%), Gaps = 31/347 (8%)
Query: 113 ITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFS 172
+T+ +L V A L A G+R GDRV+ Y+P I +AV+ +LA A +G V T F
Sbjct: 122 VTWAELRRQVASLAAELRALGVRPGDRVSGYLPNIPQAVVALLATAAVGGVWTSCAPDFG 181
Query: 173 SDALAERLSDAKAKLLVTADGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLD 232
+ ++ +R + +L T DG G + + + T + + T + + + L
Sbjct: 182 ARSVLDRFQQVEPVVLFTVDGYRYGGKEHDRRDTVAELRRELPT-----LRAVIHIPLLG 236
Query: 233 RVTPGGSLKSEIKDLYNWNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKP 292
P G+L +W E L E V + PL+VLY+SG+TG P
Sbjct: 237 TEAPDGAL--------DW---------ETLTAADAEPVYEQVPFDHPLWVLYSSGTTGLP 279
Query: 293 KGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFE 352
K +V + G L+ D D ++ GW+ + V + L T V+++
Sbjct: 280 KAIVQSQGGILVEHLKQLGLHCDLGPGDRFFWYTSTGWMMWNFLV--SGLLTGTTIVLYD 337
Query: 353 GTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGE 412
G+P FP D W I + T F T+ + A +L DLS+++ + + G
Sbjct: 338 GSPGFPATDAQWRIAERTGATLFGTSAAYVMACRKAGVHPARDL---DLSAIQCVATTGS 394
Query: 413 PINPAAWLWYYTRIGKERCSIVDTFWQTETGG-HVITGLPGATPMKP 458
P+ P + W + D + + +GG V + GA P P
Sbjct: 395 PLPPDGFRWLHDEFA---AGGADLWIASVSGGTDVCSCFAGAVPTLP 438
Score = 70.5 bits (165), Expect = 1e-10
Identities = 48/181 (26%), Positives = 77/181 (42%), Gaps = 6/181 (3%)
Query: 523 GYLVFARPWPGMMRTLLEDQD--RFERVYFSKFPGYYCTGDGVRRDEDGYLWITGRIDDM 580
G LV P P M D D R+ YF +PG + GD + G + I GR D
Sbjct: 468 GELVVTNPMPSMPIRFWNDPDGSRYHDSYFDTYPGVWRHGDWITLTSRGSVVIHGRSDST 527
Query: 581 LNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALYCFVVLKEGLQFDADLVKTL 640
LN G M +A++ + P + E+ V+ G + FV L G D L+ +
Sbjct: 528 LNRQGVRMGSADIYEAVERLPEIRESLVIGIEQPDGGYWMPLFVHLAPGATLDDALLDRI 587
Query: 641 TLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKIAVGDHEVGDISTLADPGVVEE 700
+R + PD + PG+P T +GK + ++++ G + +PG ++
Sbjct: 588 KRTIRANLSPRHVPDEVIEVPGIPHTLTGKRIEVPVKRLLQGT----PLDKAVNPGSIDN 643
Query: 701 L 701
L
Sbjct: 644 L 644
>UniRef50_Q0A597 Cluster: AMP-dependent synthetase and ligase; n=2;
Ectothiorhodospiraceae|Rep: AMP-dependent synthetase and
ligase - Alkalilimnicola ehrlichei (strain MLHE-1)
Length = 553
Score = 98.3 bits (234), Expect = 6e-19
Identities = 65/204 (31%), Positives = 104/204 (50%), Gaps = 13/204 (6%)
Query: 264 GESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYW 323
G++ PP E P + +TSG+ G PK V+H + A+ R V + +W
Sbjct: 175 GQAEPVPPVSTGPEYPALLHFTSGTLGPPKCVLHAHRAAAAHVASG-RLVLELSPGSRHW 233
Query: 324 CTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIR 383
CTAD+GW+TG +Y + PL AT+++ E P F + R++ ++ + ++ + T+PTA+R
Sbjct: 234 CTADLGWVTGVSYAMLVPLLCGATTLIDE--PPF-EAQRWYGLLEQERIQSWVTSPTALR 290
Query: 384 AL-MAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTET 442
L A + DG DLS+L+ L S GEP++ W G + +WQ+ET
Sbjct: 291 LLRRAGTEIADG----VDLSALQRLFSTGEPLDAPLTHWSQATFG---TPARNGWWQSET 343
Query: 443 GGHVITGLPGATPMKPGAAEKKHP 466
G +I G P+ PG + P
Sbjct: 344 GVIMIAQY-GDEPVAPGRMGRAVP 366
Score = 88.6 bits (210), Expect = 5e-16
Identities = 55/176 (31%), Positives = 85/176 (48%), Gaps = 6/176 (3%)
Query: 504 GVEPKILN--EDGVEIEGPGE-GYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYCTG 560
G+E ++ +DGV GE G + WP L D +R+ + + G+Y +G
Sbjct: 367 GIEVALVRHGDDGVTRVPRGEVGEIAVRSGWPSQFLAYLGDTERYRQAFLD---GWYLSG 423
Query: 561 DGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEAL 620
D +R DG L GR DD++ G+++ AEVE VL P V+E+AV PH + +
Sbjct: 424 DLAKRLPDGELQFLGRSDDVIKTRGYMVGPAEVEAVLNRHPAVAESAVAGVPHRLTHTVV 483
Query: 621 YCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRIL 676
+VV + L + L + R+ +G P I LP+T GK++RR L
Sbjct: 484 AAWVVPNARPEDPERLRRELLVYARRALGPAVTPRRITLVDELPRTPGGKVLRRAL 539
Score = 74.1 bits (174), Expect = 1e-11
Identities = 42/129 (32%), Positives = 69/129 (53%), Gaps = 1/129 (0%)
Query: 68 RVFVKFMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFAN 127
R ++K + + LN+ Y LDR+V+ G GD A W G ++ +Y +LL+ +FA
Sbjct: 14 RHWLKGLPDGRLNMAYEALDRHVEAGGGDHEALVWRGLD-NERRASSYAELLEASARFAG 72
Query: 128 GLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKL 187
L A+G+ G+RV P E I L R GAV +F + + +RL+ ++A++
Sbjct: 73 ALRARGVGLGERVCTLAPRRPEPFIAGLGALRQGAVFAPLFPVYGPQPVRQRLTVSEARV 132
Query: 188 LVTADGAWR 196
LVT + +R
Sbjct: 133 LVTTEQLYR 141
>UniRef50_Q8R8N5 Cluster: Acyl-CoA synthetases
(AMP-forming)/AMP-acid ligases II; n=4; Clostridia|Rep:
Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II -
Thermoanaerobacter tengcongensis
Length = 495
Score = 97.9 bits (233), Expect = 8e-19
Identities = 61/181 (33%), Positives = 96/181 (53%), Gaps = 8/181 (4%)
Query: 499 GFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYC 558
GFP GVE KI++E+ E+ G LV P ++ + E + G+
Sbjct: 323 GFPLPGVEAKIVDENDNELPVGEIGELVLKGP-----NVMVGYHNMPEETAKTLRNGWLH 377
Query: 559 TGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGE 618
TGD ++DEDGY +I R+ DM+ G + E+E VL + P V EAAVV +KGE
Sbjct: 378 TGDLAKKDEDGYFYIVDRLKDMIITGGFNVYPREIEEVLLTHPAVLEAAVVGVGDPLKGE 437
Query: 619 ALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRK 678
+ F+VLKEG + D + L ++ KI ++ P + LPKT +GK+ +++L++
Sbjct: 438 EIKAFIVLKEGAEADR---RELQSFLKDKIASYKIPKYFEFVKELPKTPTGKVNKKLLKQ 494
Query: 679 I 679
+
Sbjct: 495 M 495
>UniRef50_Q3W9E5 Cluster: AMP-dependent synthetase and ligase; n=2;
Actinomycetales|Rep: AMP-dependent synthetase and ligase
- Frankia sp. EAN1pec
Length = 573
Score = 97.9 bits (233), Expect = 8e-19
Identities = 122/429 (28%), Positives = 179/429 (41%), Gaps = 60/429 (13%)
Query: 271 PEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGW 330
P A +D F+ YTSG+TG PKG ++T L R++ DV + A +
Sbjct: 202 PVETALDDTAFLTYTSGTTGPPKGALNTHRNCLNSVLNYGRWLL-LQPGDVVFAIAPLFH 260
Query: 331 ITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYN 390
ITG + L N T M + P V ++ ++ T +I A A +
Sbjct: 261 ITGLSLNAGIALLNDTTLSM--SGRFEPSV-----VLEAFRDHGVTTTIGSITAFNAFFR 313
Query: 391 VEDGNLTMPD-LSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTETGGHVITG 449
V+ P+ ++++ L S G PI P+ + +R G +I + TET G
Sbjct: 314 VDGAG---PEHFAAVKRLYSGGAPIPPSTVEAFRSRFGPYLHNI---WGMTETTG----- 362
Query: 450 LPGATPMKPGAAEKKHPVYYSSMDTFRPKQGWDRTVMIVHLPNKSNRTRGFPFFGVEPKI 509
G + PGAA H G T+ I G P V+ I
Sbjct: 363 --GGIAVPPGAAAPVH--------------GPSGTLSI-----------GVPMQNVDVWI 395
Query: 510 LNEDGVEIEGPGEGYLVFARPW--PGMMRTLLEDQDRFERVYFSKFPGYYCTGDGVRRDE 567
+E G EG LV + P PG R E + G TGD D
Sbjct: 396 TDESGAPRPPGVEGELVISAPQVIPGYWRNP-------EASAHALAGGRLRTGDVAVLDA 448
Query: 568 DGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALYCFVVLK 627
G++++ R+ D +N SG + EVE VL P V EAAVV P +GE + +V L+
Sbjct: 449 AGWVYLVDRVKDQINTSGFKVWPREVEDVLYEHPDVFEAAVVGLPDAYRGETVAAYVSLR 508
Query: 628 EGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKIAVGDHEVG 687
+G A + LT R+++ A+ P I P LPKT +GKI R +LR+ A +
Sbjct: 509 DGA---ATTPEELTAFARERLAAYKYPRRISILPELPKTATGKIQRAVLREQAPAGQVIP 565
Query: 688 DISTLADPG 696
+ A+PG
Sbjct: 566 ALPR-AEPG 573
>UniRef50_Q5V0W0 Cluster: Medium-chain fatty acid-CoA ligase; n=5;
Halobacteriaceae|Rep: Medium-chain fatty acid-CoA ligase
- Haloarcula marismortui (Halobacterium marismortui)
Length = 551
Score = 97.9 bits (233), Expect = 8e-19
Identities = 60/185 (32%), Positives = 95/185 (51%), Gaps = 6/185 (3%)
Query: 495 NRTRGFPFFGVEPKILNEDGVEIEGPGE--GYLVFARPWPGMMRTLLEDQDRFERVYFSK 552
+ + G P G+E K++N DG E+ GE G L PW + + D E+
Sbjct: 352 SHSAGLPIAGLEFKVVNTDGEEVPWDGESLGELWMRGPW--VTQEYYNAPDATEQAVTDD 409
Query: 553 FPGYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKP 612
G++ TGD VR +GY+ + R+DD++ G +++ EVE + V EAAVVP P
Sbjct: 410 --GWFKTGDIVRVSPEGYVDVVDRMDDLVKSGGEWIASVEVENAVMGHDEVVEAAVVPVP 467
Query: 613 HEVKGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIM 672
HE E FVV ++ + +A L + + LV + ++ PD I+ G+PK +GK
Sbjct: 468 HERWDERPAAFVVTRDAVSDEAALRQEIKDLVAESYPSWWVPDAIRLVDGIPKGATGKFS 527
Query: 673 RRILR 677
++ LR
Sbjct: 528 KQTLR 532
Score = 34.7 bits (76), Expect = 8.7
Identities = 16/42 (38%), Positives = 26/42 (61%), Gaps = 1/42 (2%)
Query: 261 VLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGY 302
+ +G+ + P+ + + P + YTSG+TGKPKGV +T Y
Sbjct: 158 IADGDPDYSFPQ-LPEDQPAGMCYTSGTTGKPKGVEYTQKMY 198
>UniRef50_A3JB96 Cluster: Acetyl-coenzyme A synthetase; n=6;
Gammaproteobacteria|Rep: Acetyl-coenzyme A synthetase -
Marinobacter sp. ELB17
Length = 668
Score = 97.1 bits (231), Expect = 1e-18
Identities = 83/315 (26%), Positives = 141/315 (44%), Gaps = 26/315 (8%)
Query: 112 RITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGF 171
R TY +L V L ++G+ KGDRVA + EA++ MLA +GA+ + F
Sbjct: 122 RRTYTELRADVGALEAYLCSQGVIKGDRVAGIVTNGYEAMVGMLAATSMGALWSSASPDF 181
Query: 172 SSDALAERLSDAKAKLLVTADGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHL 231
A+ +R + L+ +G G +++ ++ I + C+V +
Sbjct: 182 GIGAILDRFGQIEPTALIAVNGYGYGGKVFQRQQEFAQLISGLPSL------KCVV--SV 233
Query: 232 DRVTPGGSLKSEIKDLYNWNEETDIWWHEVLEGESNICPPEW--VAAEDPLFVLYTSGST 289
++ ++ S + +D WH+ + + PP + VA + P+++LY+SG+T
Sbjct: 234 PQLPDAPAIDSPLV--------SD--WHDAIAAGAGT-PPSFTPVAPDHPVYILYSSGTT 282
Query: 290 GKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSV 349
GKPK +VH TAG L+ A D D + GW+ + + L A +
Sbjct: 283 GKPKCIVHGTAGLLVNHAKELMLHGDVGSGDRFMYFTTCGWMMWNWQA--SALLTGAAVI 340
Query: 350 MFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGS 409
+G+P +P ++ W + KVT F T+ + +L DLS LRV+ S
Sbjct: 341 TVDGSPGYPSLNMLWQTVADEKVTHFGTSARFLAGCRKDGMTPAKDL---DLSVLRVVFS 397
Query: 410 VGEPINPAAWLWYYT 424
G P+ P + W YT
Sbjct: 398 TGSPLLPEDYDWIYT 412
Score = 80.2 bits (189), Expect = 2e-13
Identities = 57/207 (27%), Positives = 97/207 (46%), Gaps = 10/207 (4%)
Query: 502 FFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQD--RFERVYFSKF----PG 555
F GV+ +++G + G G LV +P P M + +D D R+ YF F PG
Sbjct: 451 FLGVDAAAFDDNGQSVSS-GRGELVCRQPLPSMPVSFWDDPDGERYRNAYFDTFAESAPG 509
Query: 556 YYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEV 615
+ GD + E G I GR D LN G + TAE+ + ++ + ++ VV + ++
Sbjct: 510 VWAHGDFIEFTEHGGAIIYGRSDATLNPGGVRIGTAEIYRQVETEAAIKDSLVVGR--QI 567
Query: 616 KGEA-LYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRR 674
+G+ + VVL +G +L+K L +R+ P I P +P TRSGK +
Sbjct: 568 EGDVEVVLLVVLADGETLSDELLKRLKTQIRKGASPRHVPHHIIPVPDIPYTRSGKKVEL 627
Query: 675 ILRKIAVGDHEVGDISTLADPGVVEEL 701
+ ++ G + LA+P ++ +
Sbjct: 628 AVARLINGSARSDNRDALANPEALDAI 654
>UniRef50_Q91VA0-2 Cluster: Isoform 2 of Q91VA0 ; n=3;
Euarchontoglires|Rep: Isoform 2 of Q91VA0 - Mus musculus
(Mouse)
Length = 546
Score = 96.7 bits (230), Expect = 2e-18
Identities = 60/182 (32%), Positives = 92/182 (50%), Gaps = 2/182 (1%)
Query: 503 FGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYCTGDG 562
+G I++E G + EGY+ + +E ++ E + +Y +GD
Sbjct: 363 YGQSETIIDEKGNILPPNTEGYIGIRIKPTRPLGLFMEYENSPESTSEVECGDFYNSGDR 422
Query: 563 VRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALYC 622
DE+GY+W GR DD++N SG+ + EVE LA P V+E+AVV P + +GE +
Sbjct: 423 ATIDEEGYIWFLGRGDDVINASGYRIGPVEVENALAEHPAVAESAVVSSPDKDRGEVVKA 482
Query: 623 FVVLK-EGLQFDAD-LVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKIA 680
F+VL E L D + L+K L V+ + P ++ LPKT +GKI R+ LR
Sbjct: 483 FIVLNPEFLSHDQEQLIKELQHHVKSVTAPYKYPRKVEFVSELPKTVTGKIKRKELRNKE 542
Query: 681 VG 682
G
Sbjct: 543 FG 544
Score = 60.1 bits (139), Expect = 2e-07
Identities = 44/166 (26%), Positives = 70/166 (42%), Gaps = 11/166 (6%)
Query: 277 EDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTY 336
+DP+ + +TSG+TG PK H + R + D+ WC +D GWI
Sbjct: 214 KDPMAIFFTSGTTGYPKMAKHNQGLAFRSYIPSCRKLLKLKTSDILWCMSDPGWILATVG 273
Query: 337 VVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNL 396
+ P + T + + PKV ++ KY +TQ AP R ++ + NL
Sbjct: 274 CLIEPWTSGCTVFIHHLPQFDPKV--IVEVLFKYPITQCLAAPGVYRMVLQQ---KTSNL 328
Query: 397 TMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTET 442
P L + GE + P + + R G SI + + Q+ET
Sbjct: 329 RFPTLEHCT---TGGESLLPEEYEQWKQRTG---LSIHEVYGQSET 368
Score = 47.6 bits (108), Expect = 0.001
Identities = 26/91 (28%), Positives = 46/91 (50%), Gaps = 1/91 (1%)
Query: 101 FWEGNSPDDYTRITYRKLLDLVCQFANGL-LAKGIRKGDRVAVYMPMILEAVICMLACAR 159
FW N D + ++RKL DL C+ AN G+++GD +A+ +P + E + + C R
Sbjct: 70 FWWVNGQGDEIKWSFRKLRDLTCRTANVFEQICGLQQGDHLALILPRVPEWWLVTVGCMR 129
Query: 160 IGAVHTVVFAGFSSDALAERLSDAKAKLLVT 190
G + + + R+ ++AK +VT
Sbjct: 130 TGIIFMPGTTQLKAKDILYRIQISRAKAIVT 160
>UniRef50_Q89HB8 Cluster: Bll6076 protein; n=17; Bacteria|Rep:
Bll6076 protein - Bradyrhizobium japonicum
Length = 572
Score = 96.7 bits (230), Expect = 2e-18
Identities = 60/182 (32%), Positives = 94/182 (51%), Gaps = 7/182 (3%)
Query: 499 GFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYC 558
G P G E KI+++ G ++ G LV P R L +++ +R Y G+
Sbjct: 386 GKPVPGYEAKIVDDAGNDVPPGTMGRLVVRGPTG--CRYLADER---QRKYVQN--GWNI 438
Query: 559 TGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGE 618
TGD D+DGY W R DDM+ +G+ ++ +VE VL + P V+E VV P E +G
Sbjct: 439 TGDTYLMDDDGYFWYQSRSDDMIVSAGYNIAGTDVEAVLLTHPSVAECGVVGAPDEARGM 498
Query: 619 ALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRK 678
+ +++ G+ DA L L V+++I + P I+ LPKT +GK+ R LR+
Sbjct: 499 IVKAYIIAAPGVTPDAQLAAELQEYVKREIAPYKYPRAIEFVTQLPKTETGKLKRFALRQ 558
Query: 679 IA 680
+A
Sbjct: 559 LA 560
Score = 60.9 bits (141), Expect = 1e-07
Identities = 55/194 (28%), Positives = 88/194 (45%), Gaps = 17/194 (8%)
Query: 275 AAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGH 334
A++D + +TSG+TG PKG +H L R + ++D + +A + + G
Sbjct: 216 ASDDVCLIAFTSGTTGDPKGTMHFHRDMLAVCDGYARNILRAEQKDRFVGSAPLAFTFGF 275
Query: 335 TYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDG 394
V++ P+ A+ V+ E T D + I +YK T +TAPTA RA++ G
Sbjct: 276 GGVLF-PMHIGASFVVLEKT----TPDDILTAIEQYKTTVCFTAPTAYRAMI-------G 323
Query: 395 NLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTETGGHVITGLPGAT 454
L D+SSLR S GE + + ++ G ++D TE H+
Sbjct: 324 KLPGRDISSLRKCVSAGETLPKPTFDAWFKATG---IKLMDGIGSTEM-LHIFISAT-ED 378
Query: 455 PMKPGAAEKKHPVY 468
++PGA K P Y
Sbjct: 379 EIRPGATGKPVPGY 392
>UniRef50_Q12D64 Cluster: AMP-dependent synthetase and ligase; n=8;
Burkholderiales|Rep: AMP-dependent synthetase and ligase
- Polaromonas sp. (strain JS666 / ATCC BAA-500)
Length = 571
Score = 96.7 bits (230), Expect = 2e-18
Identities = 53/140 (37%), Positives = 75/140 (53%), Gaps = 13/140 (9%)
Query: 551 SKFPGYYC-TGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVV 609
+KF G +C TGD RRD +GYLW GR DD+ +G+ + E+E L P V+ AAVV
Sbjct: 418 AKFTGDWCRTGDLARRDAEGYLWYEGRADDVFKAAGYRIGPGEIENCLVKHPAVANAAVV 477
Query: 610 PKPHEVKGEALYCFVVL-------KEGL-----QFDADLVKTLTLLVRQKIGAFAAPDTI 657
PKP +G + +VVL + G QFD ++ TL V+ + + P I
Sbjct: 478 PKPDRERGAVVKAYVVLAPDFMADRSGFPGGADQFDLEMTATLQAHVKTMLAPYEYPKEI 537
Query: 658 QNAPGLPKTRSGKIMRRILR 677
+ LP T +GK+ RR+LR
Sbjct: 538 EFIDALPMTTTGKVQRRVLR 557
Score = 54.4 bits (125), Expect = 1e-05
Identities = 54/220 (24%), Positives = 93/220 (42%), Gaps = 19/220 (8%)
Query: 255 DIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVV---HTTAGYLM-YAAATF 310
DI + L + AED ++YTSG+TG PKG + G L + +
Sbjct: 160 DIDYETALAAQQQAFTAVRTKAEDAAILIYTSGTTGPPKGALLPHRALIGNLPGFVCSQN 219
Query: 311 RYVFDYHRR----DVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSI 366
+ FD V+W AD W G + L V F G + P++ +++
Sbjct: 220 WFGFDGKANAGTDAVFWSPADWAWTGGLMDALLPTLYFGRPIVAFNGR-FSPEL--AFTL 276
Query: 367 INKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRI 426
+ VT + PTA++A+M Y + + L+ + S GE + A + + ++
Sbjct: 277 MAGQGVTHTFLFPTALKAMMKAYPRPREHFQL----KLQAMMSAGEAVGDAVFAYCQEQL 332
Query: 427 GKERCSIVDTFWQTETGGHVITGLPGATPMKPGAAEKKHP 466
G ++ + F QTE +V+ P +PG+ K +P
Sbjct: 333 G---VTVNEMFGQTEI-NYVVGNCSSLWPARPGSMGKGYP 368
Score = 49.6 bits (113), Expect = 3e-04
Identities = 27/84 (32%), Positives = 44/84 (52%)
Query: 111 TRITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAG 170
T TYR L ++ L G+++GDRVA+ MP E + +A ++GAV +
Sbjct: 49 TLYTYRALQQAADALSHVLAGLGVQRGDRVAIVMPQRFETAVAYMAIFQMGAVAMPLSML 108
Query: 171 FSSDALAERLSDAKAKLLVTADGA 194
F +AL RL D++A + + + A
Sbjct: 109 FGPEALEFRLHDSEAVVAICDESA 132
>UniRef50_UPI00005104B2 Cluster: COG0318: Acyl-CoA synthetases
(AMP-forming)/AMP-acid ligases II; n=2; Brevibacterium
linens BL2|Rep: COG0318: Acyl-CoA synthetases
(AMP-forming)/AMP-acid ligases II - Brevibacterium
linens BL2
Length = 551
Score = 95.9 bits (228), Expect = 3e-18
Identities = 68/197 (34%), Positives = 100/197 (50%), Gaps = 9/197 (4%)
Query: 491 PNKSNRTRGFPFFGVEPKILNEDGVEIEGPGE-GYLVFARPWPGMMRTLLEDQDRFERVY 549
P+ N + G P +IL++ G + GP E G + + P ++ + E+
Sbjct: 352 PDSGNLSCGLPQPDTMIRILDDFGEPL-GPNEIGEVAVSGP------EVVAEYINNEKAT 404
Query: 550 FSKFP-GYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAV 608
+ P G TGD +EDG+L+I R DM+N SG + EVE VL + P + EAAV
Sbjct: 405 AEQLPDGELRTGDVGYMNEDGWLFIVDRKKDMINASGFKVWPREVEDVLYTHPAIQEAAV 464
Query: 609 VPKPHEVKGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRS 668
V P E +GE + FV L+ G + DA + R+K+ ++ AP + LPKT S
Sbjct: 465 VGIPDEYRGENVAAFVTLQSGPEADAVTEAEIVEFCREKLASYKAPRQVTIIDELPKTSS 524
Query: 669 GKIMRRILRKIAVGDHE 685
GKI+RR +R AV E
Sbjct: 525 GKILRRTIRADAVAAAE 541
>UniRef50_Q5GMK0 Cluster: Fatty-acid-CoA ligase; n=1; uncultured
bacterium|Rep: Fatty-acid-CoA ligase - uncultured
bacterium
Length = 515
Score = 95.9 bits (228), Expect = 3e-18
Identities = 63/179 (35%), Positives = 90/179 (50%), Gaps = 8/179 (4%)
Query: 499 GFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYC 558
G P +G E +IL +DG + G +V +M+ Q E + G++
Sbjct: 336 GLPVWGCEMRILRDDGTFADVGEVGEIVMRGH--NVMKGYYNKQVATEEAFEG---GWFH 390
Query: 559 TGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGE 618
TGD R DEDGY +I R D++ SG + EVE +L P V EAAVV P E +GE
Sbjct: 391 TGDLARMDEDGYFFIVDRKKDLIIRSGMNVYPREVEEILYGHPAVLEAAVVGVPDEARGE 450
Query: 619 ALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILR 677
+ FV LK G + A L R+++ F P +++ P LPK +GKI++R LR
Sbjct: 451 EVKAFVTLKSGSEASAG---ELLAYCRERMAKFKCPKSLEFLPSLPKGPTGKILKRQLR 506
Score = 40.7 bits (91), Expect = 0.13
Identities = 27/83 (32%), Positives = 41/83 (49%), Gaps = 1/83 (1%)
Query: 108 DDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVV 167
DDY R +Y+++L + A+ L AKGIR+GD+VA+ +P + GAV V
Sbjct: 25 DDY-RFSYQEVLTYARRVASLLHAKGIRRGDKVAMMIPNSPHFPVIYFGALLAGAVVVPV 83
Query: 168 FAGFSSDALAERLSDAKAKLLVT 190
+ L D+ A+L T
Sbjct: 84 NCLLKGHEIHYYLEDSDARLFFT 106
Score = 36.7 bits (81), Expect = 2.2
Identities = 42/138 (30%), Positives = 57/138 (41%), Gaps = 9/138 (6%)
Query: 277 EDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTY 336
+D +LYTSG+TG PKG T A T + DV + G T
Sbjct: 164 DDTAVLLYTSGTTGHPKGAELTHFNMFFNAYYTMHRILYATADDVSLGVLPLFHSFGQTC 223
Query: 337 VVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNL 396
V A L T V+ P F + R +I + +V+ PT + M H E N
Sbjct: 224 VQNATLMAGGTMVL---VPRF-EAQRVLEVIQRDRVSVIAMVPT-MYFWMLH---EKRNG 275
Query: 397 TMPDLSSLRVLGSVGEPI 414
T DLSS+R+ S G +
Sbjct: 276 TY-DLSSVRMAVSGGSAL 292
>UniRef50_Q9A9L4 Cluster: Long-chain-fatty-acid--CoA ligase,
putative; n=20; Proteobacteria|Rep:
Long-chain-fatty-acid--CoA ligase, putative -
Caulobacter crescentus (Caulobacter vibrioides)
Length = 530
Score = 95.5 bits (227), Expect = 4e-18
Identities = 67/186 (36%), Positives = 90/186 (48%), Gaps = 7/186 (3%)
Query: 492 NKSNRTRGFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFS 551
NK R G P GVE KI++E G + P V R M D+ + +
Sbjct: 340 NKRMRAAGLPMPGVELKIIDEAGKSLP-PNTVGEVAVRSSANMAGYWKLDEATAKTM--- 395
Query: 552 KFPGYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPK 611
G+ TGD DEDGYL+I R+ DM+ G + AEVE + P V+E AV+
Sbjct: 396 DADGWLRTGDAGYLDEDGYLFIHDRVKDMIISGGENIYPAEVESAVYGHPHVAEVAVIGV 455
Query: 612 PHEVKGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKI 671
P + GEA+ V K G+ DAD + R +I F AP ++ P LP+ SGKI
Sbjct: 456 PDDKWGEAVKAVVAPKPGVTPDAD---DIIAFARTRIAHFKAPKSVDFIPALPRNASGKI 512
Query: 672 MRRILR 677
+RR LR
Sbjct: 513 LRRELR 518
Score = 36.7 bits (81), Expect = 2.2
Identities = 28/93 (30%), Positives = 44/93 (47%), Gaps = 6/93 (6%)
Query: 96 DKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICML 155
D +AF +EG T+ +L Q AN LLA G+ GDR+A +L
Sbjct: 26 DAVAFSFEGRET------TFAQLDRHTNQVANALLAAGLSTGDRIAYVGKNSDHYFELLL 79
Query: 156 ACARIGAVHTVVFAGFSSDALAERLSDAKAKLL 188
A+ G V T + ++ +A + D++AKL+
Sbjct: 80 GAAKAGVVTTPIGWRLAAPEIAYIVGDSEAKLV 112
>UniRef50_Q2FT08 Cluster: AMP-dependent synthetase and ligase; n=14;
cellular organisms|Rep: AMP-dependent synthetase and
ligase - Methanospirillum hungatei (strain JF-1 / DSM
864)
Length = 616
Score = 95.5 bits (227), Expect = 4e-18
Identities = 60/181 (33%), Positives = 89/181 (49%), Gaps = 1/181 (0%)
Query: 499 GFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYC 558
G P G ++ +EDG ++ PGE + + P + +E E + G+Y
Sbjct: 420 GKPSPGWVIELHDEDGKPVK-PGEEGSIAIKTDPRPVGFFMEYWGNEEANANAFRDGFYY 478
Query: 559 TGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGE 618
TGD RD DGY W GR DD++ SG+ + EVE + V EAAVV P ++G
Sbjct: 479 TGDRAVRDGDGYFWFVGRDDDVIKASGYRIGPFEVESAIIEHQAVQEAAVVGSPDIIRGF 538
Query: 619 ALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRK 678
+ F+VLK G + L + + V+ + P I+ LPKT SGKI R+ LR+
Sbjct: 539 VVKAFIVLKAGYEPSEKLAREIQEYVKSITAPYKYPRKIEFVKELPKTISGKIKRKDLRE 598
Query: 679 I 679
+
Sbjct: 599 M 599
Score = 66.5 bits (155), Expect = 2e-09
Identities = 49/167 (29%), Positives = 75/167 (44%), Gaps = 11/167 (6%)
Query: 276 AEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHT 335
A DP+ + ++SG+TG+PK V+H+ A Y + T R+ D D+++ +D GW
Sbjct: 247 ATDPMVIFFSSGTTGEPKMVLHSQA-YPLGHIVTARFWHDVRNNDLHFTVSDTGWAKSAW 305
Query: 336 YVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGN 395
++ A +++ F +I KY +T F PT R L+ +
Sbjct: 306 GKLFGQWIEGAAIFVYDYRNKF-NATELLPLIEKYGITTFCAPPTIYRMLIM------AD 358
Query: 396 LTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTET 442
L D S LR S GE INP + G E I + + QTET
Sbjct: 359 LRKYDFSELRHCVSAGELINPEVIKAWKDATGLE---IYEGYGQTET 402
Score = 42.7 bits (96), Expect = 0.033
Identities = 34/140 (24%), Positives = 64/140 (45%), Gaps = 4/140 (2%)
Query: 51 APKPGGFMKYNFDITKGRVFVKFMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDY 110
+P P N+D T ++ E N ++++D K +K+A W N +
Sbjct: 53 SPAPHRHNMQNYDETYRNFRIEVPEY--FNFGFDVVDAWAKKD-RNKLAMVWT-NQEGEE 108
Query: 111 TRITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAG 170
T+R + + N ++ I KGDRV + + + E ++A +IGAV+
Sbjct: 109 KFFTFRDISRRSNEIVNMMIKYKIGKGDRVLIMLHRVPEWWFMVIALIKIGAVYIPAPTM 168
Query: 171 FSSDALAERLSDAKAKLLVT 190
+ LA R+ ++AK+++T
Sbjct: 169 LTPKDLAYRIKTSEAKMVIT 188
>UniRef50_Q0HLV4 Cluster: AMP-dependent synthetase and ligase; n=21;
Proteobacteria|Rep: AMP-dependent synthetase and ligase
- Shewanella sp. (strain MR-4)
Length = 534
Score = 95.1 bits (226), Expect = 6e-18
Identities = 69/182 (37%), Positives = 98/182 (53%), Gaps = 6/182 (3%)
Query: 497 TRGFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGY 556
T G P G E K+L+E+G E+ GE + AR P +M + V + G+
Sbjct: 355 TIGKPVLGTEVKLLDENGNEV-AQGEAGELAARG-PQVMLGYWNNLQETANVMTAD--GF 410
Query: 557 YCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVK 616
+ TGD +E+G+ I R DM+ VSG + EVE VLAS P + E AVV E
Sbjct: 411 FKTGDIAILNEEGFHQIVDRKKDMIIVSGFNVYPNEVENVLASHPNIIECAVVGVKDEHS 470
Query: 617 GEALYCFVVLKEGLQFDADLVKTLTL-LVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRI 675
GEA+ FVVLK+ Q D + +KT + R+++ A+ P I+ P LPK+ GKI+RR
Sbjct: 471 GEAVKAFVVLKDDSQ-DHEQMKTAIINFCREQLTAYKLPKLIEFMPQLPKSTVGKILRRE 529
Query: 676 LR 677
L+
Sbjct: 530 LK 531
>UniRef50_Q3ABP3 Cluster: Long-chain-fatty-acid--CoA ligase; n=1;
Carboxydothermus hydrogenoformans Z-2901|Rep:
Long-chain-fatty-acid--CoA ligase - Carboxydothermus
hydrogenoformans (strain Z-2901 / DSM 6008)
Length = 491
Score = 94.3 bits (224), Expect = 1e-17
Identities = 63/176 (35%), Positives = 97/176 (55%), Gaps = 11/176 (6%)
Query: 504 GVEPKILNEDGVEIEGPGE--GYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYCTGD 561
G+E KI++E+ E+ PGE +VF + +M+ + +V + G TGD
Sbjct: 319 GMEVKIVDENLNELP-PGEVGELMVFGK---NVMKGYYNKPEETAKVLVN---GGLLTGD 371
Query: 562 GVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALY 621
++DE GYL+I R D++ VSG + EVE + P V E AVV P V+GEA+
Sbjct: 372 LGKKDEQGYLYIVDRKKDLIIVSGFNVYPTEVERAILDHPAVREVAVVGVPDGVRGEAVK 431
Query: 622 CFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILR 677
F+ LKEG ++ K L+ +R K+ A+ P ++ P LPK +GKIM+++LR
Sbjct: 432 AFITLKEG--YNNLTRKELSEFLRDKLAAYKIPRYVEVLPELPKNATGKIMKKVLR 485
Score = 37.9 bits (84), Expect = 0.94
Identities = 48/207 (23%), Positives = 83/207 (40%), Gaps = 19/207 (9%)
Query: 260 EVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRR 319
E++ E+ P + D +LYTSG+TG PKG + T + + R+ +
Sbjct: 131 EIMNLEAKFIEPTY---NDVCTILYTSGTTGFPKGAMLTHENLIFDTDSVTRFA-EVDEN 186
Query: 320 DVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAP 379
D Y + T + APL AT + +G + P+ ++ K+T F P
Sbjct: 187 DNYLAVLPLFHSFAWTACLLAPLYTGATCTIEDG--FNPR--EIGKVLVAEKITIFLGVP 242
Query: 380 TAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQ 439
+ L+ + L +S+ + S G + P ++Y K +V+ +
Sbjct: 243 SMFVYLLEY-------LPREAFNSVHLAVSGGSSLPPQ---FFYAFEEKFGVPLVEGYGL 292
Query: 440 TETGGHVITGLPGATPMKPGAAEKKHP 466
TE ++T P P PG+ K P
Sbjct: 293 TE-ASPIVTLNPRRGPRIPGSIGKVLP 318
Score = 35.5 bits (78), Expect = 5.0
Identities = 18/84 (21%), Positives = 39/84 (46%)
Query: 112 RITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGF 171
++TYR++ ++ ++A KG++ GD+V + E V + G + V G
Sbjct: 24 KVTYREMAKIIEKYAVFWQQKGLKPGDKVLLVSGNSPEFVYTYFGVVKAGGIIIPVNMGL 83
Query: 172 SSDALAERLSDAKAKLLVTADGAW 195
+ + + DA+A+ + + W
Sbjct: 84 APEEIRYIFGDAQARFVAIQEKIW 107
>UniRef50_Q1ITX8 Cluster: AMP-dependent synthetase and ligase; n=1;
Acidobacteria bacterium Ellin345|Rep: AMP-dependent
synthetase and ligase - Acidobacteria bacterium (strain
Ellin345)
Length = 536
Score = 94.3 bits (224), Expect = 1e-17
Identities = 63/181 (34%), Positives = 91/181 (50%), Gaps = 7/181 (3%)
Query: 499 GFPFFGVEPKILNEDGVEIEGPGE-GYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYY 557
G+P E +IL+E G E+ PGE G LV P MR + V G+Y
Sbjct: 357 GYPAAQTECRILDEYGNEV-APGECGELVMRGPQ--FMRGYWKADAATASVLRD---GWY 410
Query: 558 CTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKG 617
+GD RRD++G+ +I R +M+ G ++ AEVEGVL P V + V+ +P G
Sbjct: 411 WSGDVARRDDEGFYFIVDRRKEMIKYCGFAVAPAEVEGVLLEHPAVRDCGVIGRPDAEHG 470
Query: 618 EALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILR 677
E F++L+ Q L + L V Q+I + P I +P+T SGKI+RR LR
Sbjct: 471 EIPMAFIILRNPQQESPQLAEDLKDFVAQRITRYKQPREIVFTDSIPRTASGKILRRELR 530
Query: 678 K 678
+
Sbjct: 531 Q 531
Score = 45.6 bits (103), Expect = 0.005
Identities = 31/98 (31%), Positives = 49/98 (50%), Gaps = 3/98 (3%)
Query: 96 DKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICML 155
+KIA +P +TY + DLV + A GL+A IR VA+Y+P E
Sbjct: 37 EKIAIVDTSTTPP--REVTYAEYADLVERMARGLIAADIRPQQVVAIYLPNCWEFCAAFH 94
Query: 156 ACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADG 193
A + GAV T++ + + +L +++A L+T DG
Sbjct: 95 AISYAGAVSTLLNPSYREREVRYQLENSEAVALIT-DG 131
>UniRef50_A7JC22 Cluster: Predicted protein; n=1; Francisella
tularensis subsp. tularensis FSC033|Rep: Predicted
protein - Francisella tularensis subsp. tularensis
FSC033
Length = 147
Score = 93.5 bits (222), Expect = 2e-17
Identities = 52/141 (36%), Positives = 83/141 (58%), Gaps = 10/141 (7%)
Query: 1 MSSRMYKPTDHVIKKSYLPSIQKYKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMK- 59
MS ++ + I ++++ S + Y+++Y+ SL E FWT+ A WH KP F K
Sbjct: 1 MSYSKFQVSQDFIDQAHINS-ELYEKLYKESLENPEQFWTKQANRIHWH---KP--FTKA 54
Query: 60 YNFDITKGRVFVKFMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLL 119
YN V +K+ ++ ELNVCYN +DR++ +++AF W+ ++P +ITYR+L
Sbjct: 55 YNSSFAP--VDIKWFDDGELNVCYNCVDRHLP-ARANQVAFIWQADNPKKSKKITYRELY 111
Query: 120 DLVCQFANGLLAKGIRKGDRV 140
VC+ AN L A G++KGD V
Sbjct: 112 HRVCEMANILEANGVKKGDVV 132
>UniRef50_Q0CFH7 Cluster: Putative uncharacterized protein; n=1;
Aspergillus terreus NIH2624|Rep: Putative
uncharacterized protein - Aspergillus terreus (strain
NIH 2624)
Length = 695
Score = 93.5 bits (222), Expect = 2e-17
Identities = 63/202 (31%), Positives = 106/202 (52%), Gaps = 7/202 (3%)
Query: 504 GVEPKILNEDGVEIEGPG-EGYLVFARPWPGMMRTLL--EDQDRFERVYFSKFPGYYCTG 560
G++ ++ ++DG +I G +G LV RP+ M L +E+ YFSKFPG +C G
Sbjct: 482 GMKARVFDDDGHDITDSGAKGELVITRPFFSMPLGFLGPTGNQAYEKSYFSKFPGVWCHG 541
Query: 561 DGVRRDE-DGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEA-AVVPKPHEVKGE 618
D VRR+ G + GR D +LN G +AE+ ++ P+V ++ AV K ++ E
Sbjct: 542 DFVRRNPVTGGFEVLGRSDGVLNPGGIRFGSAELYSIIERFPQVQDSVAVGQKLPDLHDE 601
Query: 619 ALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRK 678
+ FVVL++G + D+ L +T +R + A P + +P T +GK + ++R
Sbjct: 602 QVLLFVVLRQG-RLDSALRDDITAAIRTGLSARHVPSHVIQVKDIPYTTNGKKIEGLVRD 660
Query: 679 IAVGDHEVGDISTLADPGVVEE 700
+ G V + +A+P +EE
Sbjct: 661 VVSG-KPVTPSAAVANPESLEE 681
Score = 52.0 bits (119), Expect = 5e-05
Identities = 34/116 (29%), Positives = 57/116 (49%), Gaps = 3/116 (2%)
Query: 77 AELNVCYNLLDRNVKNGFGD-KIAFFWEGN--SPDDYTRITYRKLLDLVCQFANGLLAKG 133
A LN NLL +K +A + EG+ + R+T+R+L D V ++A+ L G
Sbjct: 89 AALNYAENLLAFGLKTKANSIAVAAYEEGDITGSREPLRLTFRQLEDEVARWAHALKRLG 148
Query: 134 IRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLV 189
+ GD V V +P ++A++ LACA GAV + + + +R K + +
Sbjct: 149 VGVGDPVGVVLPNYIDALLIFLACAACGAVFSSTAPDMGASGIIDRYRQFKPVVFI 204
Score = 48.0 bits (109), Expect = 9e-04
Identities = 33/134 (24%), Positives = 63/134 (47%), Gaps = 9/134 (6%)
Query: 321 VYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPT 380
VY+ GW+ + Y+V A LA V+++G+P +PK +I+ + V + T+P
Sbjct: 346 VYYQYTTTGWMMWN-YLVSA-LAGGTQIVLYDGSPLYPKPSSQLAIVKREHVEDWGTSPK 403
Query: 381 AIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQT 440
+ +L A + +P L L V+ G ++ + W+YT+ R ++ T
Sbjct: 404 FLESLKA------TSFAVPPLPQLAVVDVTGSALSAELYDWFYTKF-PSRLGLLSGSGGT 456
Query: 441 ETGGHVITGLPGAT 454
+ G ++ P +T
Sbjct: 457 DLVGGILMPSPMST 470
>UniRef50_Q97WU3 Cluster: Acetyl-CoA synthetase (Acetate-CoA ligase)
carboxy-end; n=2; cellular organisms|Rep: Acetyl-CoA
synthetase (Acetate-CoA ligase) carboxy-end - Sulfolobus
solfataricus
Length = 267
Score = 93.1 bits (221), Expect = 2e-17
Identities = 63/190 (33%), Positives = 94/190 (49%), Gaps = 6/190 (3%)
Query: 485 VMIVHLPNKSNR-TRGFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQD 543
+ I ++P+ S G P G E KI++EDG E+ G L M +
Sbjct: 74 IYISNIPSNSKPGCTGKPVPGYEVKIVDEDGNEVPPKTIGDLYVKGDSVAMFYW-----N 128
Query: 544 RFERVYFSKFPGYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRV 603
+E + ++ TGD RD++GY + GR DDM+ +G +S EVE L S P V
Sbjct: 129 DYESTRKNMMGSWFRTGDKFYRDDEGYYYYVGRSDDMVKTAGLWVSPIEVESALLSHPAV 188
Query: 604 SEAAVVPKPHEVKGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGL 663
EAAVV P EV + FV LK+G ++L + + +R+K+ + P I+ +
Sbjct: 189 LEAAVVGIPDEVGLVRVVGFVTLKQGYSPSSELAEEIRNYLREKLDHYKVPKEIRFITEI 248
Query: 664 PKTRSGKIMR 673
PKT +GKI R
Sbjct: 249 PKTATGKIQR 258
Score = 45.2 bits (102), Expect = 0.006
Identities = 36/102 (35%), Positives = 51/102 (50%), Gaps = 10/102 (9%)
Query: 367 INKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRI 426
I+KYK T F+ PT A++ +VED +L+SLR S GEP+ P ++ + R
Sbjct: 4 IHKYKPTIFFGVPTLYNAML---HVEDWKNY--NLTSLRFCVSAGEPLPPLIYIKWKERY 58
Query: 427 GKERCSIVDTFWQTETGGHVITGLPGATPMKPGAAEKKHPVY 468
G E I+D TE I+ +P + KPG K P Y
Sbjct: 59 GVE---ILDGIGSTEALHIYISNIPSNS--KPGCTGKPVPGY 95
>UniRef50_Q21UY9 Cluster: AMP-dependent synthetase and ligase; n=1;
Rhodoferax ferrireducens T118|Rep: AMP-dependent
synthetase and ligase - Rhodoferax ferrireducens (strain
DSM 15236 / ATCC BAA-621 / T118)
Length = 603
Score = 92.7 bits (220), Expect = 3e-17
Identities = 52/140 (37%), Positives = 71/140 (50%), Gaps = 13/140 (9%)
Query: 551 SKFPGYYC-TGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVV 609
+KF G +C TGD RD DGYLW GR DD+ +G+ + E+E L P V+ AAVV
Sbjct: 452 AKFTGDWCRTGDLALRDADGYLWYQGRADDVFKAAGYRIGPGEIENCLVKHPAVANAAVV 511
Query: 610 PKPHEVKGEALYCFVVLKEGL------------QFDADLVKTLTLLVRQKIGAFAAPDTI 657
PKP +G + +VVL +FD LV L V+ + + P I
Sbjct: 512 PKPDPARGSVVKAYVVLAPDFIAARPLDTVARAEFDLKLVAQLQAHVKGMLAPYEYPKEI 571
Query: 658 QNAPGLPKTRSGKIMRRILR 677
+ LP T +GK+ RR+LR
Sbjct: 572 EFIDALPMTSTGKVQRRVLR 591
Score = 50.8 bits (116), Expect = 1e-04
Identities = 29/84 (34%), Positives = 43/84 (51%)
Query: 114 TYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSS 173
TY +L + +N L A G+ +GDRVA+ MP E + +A ++GAV + F
Sbjct: 68 TYSELQAQANRLSNVLTALGVGRGDRVAIVMPQCFETAVAYVAVLQMGAVAMPLSMLFGP 127
Query: 174 DALAERLSDAKAKLLVTADGAWRG 197
AL RL D +A + + A A G
Sbjct: 128 QALEFRLHDGEAVVAIGAASALEG 151
Score = 46.4 bits (105), Expect = 0.003
Identities = 55/242 (22%), Positives = 95/242 (39%), Gaps = 26/242 (10%)
Query: 244 IKDLYNWNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVV---HTTA 300
+ DL ++ D+ + L E P AE+ ++YTSG+TG PKG +
Sbjct: 168 VGDLEATDQRADLNYALALAQEDAHFTPVATLAEEAAVLIYTSGTTGNPKGALIPHRALI 227
Query: 301 GYLM-YAAATFRYVFDYHRRD--------------VYWCTADVGWITGHTYVVYAPLANA 345
G L + + + FD V+W AD W G + L
Sbjct: 228 GNLTGFVCSQNWFGFDPAANPASAGLGDLPVGSDAVFWSPADWAWTGGLMDALLPTLYFG 287
Query: 346 ATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLS-SL 404
T V + G + P+ ++ VT + PTA++A+M Y + L
Sbjct: 288 RTIVAYNGR-FSPQTAL--ELMRDCHVTHTFLFPTALKAMMKAYPGSARHTVRQQFKLQL 344
Query: 405 RVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTETGGHVITGLPGATPMKPGAAEKK 464
+ + S GE + A + + ++G ++ + F QTE +++ P KPG+
Sbjct: 345 QAIMSAGEAVGDAVFDYCQQQLG---VTVNEMFGQTEI-NYIVGNCSAQWPPKPGSMGMG 400
Query: 465 HP 466
+P
Sbjct: 401 YP 402
>UniRef50_Q1E700 Cluster: Putative uncharacterized protein; n=1;
Coccidioides immitis|Rep: Putative uncharacterized
protein - Coccidioides immitis
Length = 563
Score = 92.3 bits (219), Expect = 4e-17
Identities = 66/192 (34%), Positives = 90/192 (46%), Gaps = 11/192 (5%)
Query: 499 GFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTL-------LEDQDRFERVYFS 551
G P GV ++ +G E EG + A P +TL D
Sbjct: 359 GKPLPGVPLTVITPEGEESPAEEEGEIAIATTTPEGFQTLNIFSGYLKPDGTVLRPTRQG 418
Query: 552 KFPGYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPK 611
K +Y TGD RD++GYLW GR DD++N SG+ + EVE VL P V E+AVV
Sbjct: 419 KGRSWYLTGDRAYRDDEGYLWFVGRSDDVINSSGYRIGPFEVESVLKKHPAVVESAVVAS 478
Query: 612 PHEVKGEALYCFVVLKEGLQF--DADLVKTLTLLVRQKIGAFAAPDTIQNA-PG-LPKTR 667
P + E + F+VL++ + A L+ L + + + P IQ PG LPKT
Sbjct: 479 PDAARVEVVKAFIVLQDEYKSRDSAALIAELQDFCKAETAPYKYPRRIQFVEPGFLPKTI 538
Query: 668 SGKIMRRILRKI 679
SGKI R LR +
Sbjct: 539 SGKIKRAELRAL 550
Score = 55.2 bits (127), Expect = 6e-06
Identities = 55/202 (27%), Positives = 78/202 (38%), Gaps = 17/202 (8%)
Query: 244 IKDLYNWNEETDIWWHEVL-EGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGY 302
+KD ++ E D + E L G+ +W DP + +TSG+TG PK V+H Y
Sbjct: 154 LKDTLQYSSELDKFPEEFLFRGDGR--KTKW---SDPSMIYFTSGTTGMPKMVLHNQVSY 208
Query: 303 LMYAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDR 362
+ T R D +YW ++ GW A AA V P+ ++
Sbjct: 209 PLAHVLTGRLWLDLEPGKLYWNLSEQGWAKAAWAWFGAWNCGAALFVQETVGPF--SAEQ 266
Query: 363 YWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWY 422
++ Y +T PTA R + E P L GEP+N
Sbjct: 267 TLDNLHNYPITTLCAPPTAYRQFVLPSRQEYFRRNPP--MRLEHCVGAGEPLNDQV---- 320
Query: 423 YTRIGKERC--SIVDTFWQTET 442
R KE C I D + QTET
Sbjct: 321 -IRTWKEMCGLEIRDGYGQTET 341
>UniRef50_UPI000049951B Cluster: acyl-CoA synthetase; n=2; Entamoeba
histolytica HM-1:IMSS|Rep: acyl-CoA synthetase -
Entamoeba histolytica HM-1:IMSS
Length = 1017
Score = 91.9 bits (218), Expect = 5e-17
Identities = 56/194 (28%), Positives = 103/194 (53%), Gaps = 4/194 (2%)
Query: 486 MIVHLPNKSNRTRGFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRF 545
++ +P+K+ P E ++++ + EI G + R P MM+ L + +
Sbjct: 347 LMYKMPSKATHIPAGPVAHYEVRVVDHETREILPIGLAGELEVRS-PIMMKEYLNNPEAN 405
Query: 546 ERVYFSKFPGYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSE 605
++ + ++ TGD +EDG++ ITGR+ +M+ GH + AE+ L P++ E
Sbjct: 406 KQAFTED--RWFRTGDEAVLEEDGFMRITGRVKEMIIRGGHNIWPAEINDTLIKHPKIQE 463
Query: 606 AAVVPKPHEVKGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPK 665
AAV+ P +++GE + FVV+K+G FD +L K L +++K+ F+ P I +P+
Sbjct: 464 AAVIGIPDKIQGETVVAFVVIKKGCSFD-NLEKDLKEFLKEKLVPFSIPTYIFAIEDMPR 522
Query: 666 TRSGKIMRRILRKI 679
T GK+ L++I
Sbjct: 523 TSFGKVYAPKLKEI 536
>UniRef50_Q8YBS1 Cluster: ACETYL-COENZYME A SYNTHETASE; n=38;
Proteobacteria|Rep: ACETYL-COENZYME A SYNTHETASE -
Brucella melitensis
Length = 568
Score = 91.9 bits (218), Expect = 5e-17
Identities = 65/189 (34%), Positives = 93/189 (49%), Gaps = 16/189 (8%)
Query: 499 GFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDR--FERVYFSKFP-- 554
G+ G +L+E G E+ GP E PG++ +++ F Y P
Sbjct: 383 GYAMPGYRVAVLDEAGKEV-GPNE---------PGVLAIDIDNSPLLWFTGYYKKDTPSI 432
Query: 555 --GYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKP 612
GYY TGD V + G + GR DD++ SG+ + +VE L P V+EAAVV P
Sbjct: 433 SGGYYRTGDTVEFEPHGSISFIGRADDVITSSGYRIGPFDVESALLEHPAVNEAAVVGVP 492
Query: 613 HEVKGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIM 672
+ E + FV+L G + +L + L L V++++ A A P I LPKT SGKI
Sbjct: 493 DPQRTEIVKAFVILAPGFEGTPELAEELALHVKKQLSAHAYPRQIDFVAELPKTPSGKIQ 552
Query: 673 RRILRKIAV 681
R +LRK V
Sbjct: 553 RFLLRKAEV 561
Score = 78.6 bits (185), Expect = 5e-13
Identities = 70/217 (32%), Positives = 92/217 (42%), Gaps = 14/217 (6%)
Query: 253 ETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRY 312
E DI + + S C P D ++ TSG+ G PKGV LM A R
Sbjct: 186 EGDIDFRAAVAAASTECEPVMRKGSDLFMMMSTSGTAGLPKGVPVPLRA-LMAFGAYMRD 244
Query: 313 VFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKV 372
+ RR +W AD GW G Y V PL +++ EG F + Y II + V
Sbjct: 245 AWAAQRR-YFWNIADPGWAYGLYYAVTGPLLLGVPTILNEGG--FTAENTY-DIIERLGV 300
Query: 373 TQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCS 432
T +PTA R LMA + LRV S GEP+NP W+ +G
Sbjct: 301 TSLAGSPTAFRLLMAAGPESAARVK----GRLRVASSAGEPLNPEVIRWFDACLG---AP 353
Query: 433 IVDTFWQTETGGHVITGLPGAT-PMKPGAAEKKHPVY 468
I D + QTE G V+ G P++ G+A P Y
Sbjct: 354 IHDHYGQTEL-GMVVNNHHGLEHPVRQGSAGYAMPGY 389
Score = 58.0 bits (134), Expect = 8e-07
Identities = 38/129 (29%), Positives = 57/129 (44%), Gaps = 4/129 (3%)
Query: 62 FDITKGRVFVKFMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDL 121
FDI K + + +N C DR G+ + + T +T+ L D+
Sbjct: 33 FDIAKAIALLAGNPDTGINACIECCDRYT----GENRVALHAISIDNTLTELTFEDLRDM 88
Query: 122 VCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLS 181
+ N L GI GD VA +P E V +L RIGA++ +F F A+ +R
Sbjct: 89 SARVGNMLADAGISAGDVVAGLLPRTPELVATILGAWRIGAIYQPLFTAFGPKAIEQRFG 148
Query: 182 DAKAKLLVT 190
+ AKL+VT
Sbjct: 149 TSGAKLVVT 157
>UniRef50_Q7W0W3 Cluster: Acetyl-CoA synthetase; n=2;
Bordetella|Rep: Acetyl-CoA synthetase - Bordetella
parapertussis
Length = 543
Score = 91.9 bits (218), Expect = 5e-17
Identities = 63/194 (32%), Positives = 94/194 (48%), Gaps = 4/194 (2%)
Query: 488 VHLPNKSNRTRGFPFFGVEPKILNEDGVEIEGP-GEGYLVFARPWPGMMRTLLEDQDRFE 546
V +P K+ + G PF G E +L++ G + G G+L R + + D D
Sbjct: 353 VAVPAKAG-SMGLPFPGYEIAVLDDAGQPLAGAHASGWLAKRRSADRLYWSHYWD-DAGA 410
Query: 547 RVYFSKFPGYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEA 606
+ + TGD RD +GY W GR DM+ +G+ + EVE L + V+EA
Sbjct: 411 TAELERGE-WIVTGDLAHRDAEGYYWFDGRAGDMIKSAGYRIGPFEVESALLAHGAVAEA 469
Query: 607 AVVPKPHEVKGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKT 666
AVV P ++GE + ++VL G L + + L V+ GA P ++ P LPKT
Sbjct: 470 AVVGVPDALRGELVKAYIVLLPGHAASPRLAEEIQLFVKTHCGAHLYPRIVEFVPDLPKT 529
Query: 667 RSGKIMRRILRKIA 680
+GKI R LR+ A
Sbjct: 530 DTGKIQRFALRQRA 543
Score = 69.7 bits (163), Expect = 3e-10
Identities = 62/193 (32%), Positives = 87/193 (45%), Gaps = 14/193 (7%)
Query: 277 EDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTY 336
ED ++YTSGSTG+PKG +L Y D DV W T D GW G+ +
Sbjct: 190 EDIAALIYTSGSTGRPKGGA-IAVNFLAAVWPYLTYGADMRADDVVWPTGDPGW--GYGF 246
Query: 337 VVY-APLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGN 395
V Y LA AT V P P+V ++ + +V+ F T PT +R +MA D
Sbjct: 247 VCYLGALAMGATIVSLAANP-TPEV--CLDVLARQRVSNFATTPTLLRGVMA--LGMDAV 301
Query: 396 LTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTETGGHVITGLPGATP 455
P +++R + S GEP+N ++ G+ + +D F TE G V A P
Sbjct: 302 RARP--NAVRAISSCGEPLNGEVVEFFQQAWGR---TPMDHFGATEYGLPVGNFNAVAVP 356
Query: 456 MKPGAAEKKHPVY 468
K G+ P Y
Sbjct: 357 AKAGSMGLPFPGY 369
Score = 60.9 bits (141), Expect = 1e-07
Identities = 41/137 (29%), Positives = 72/137 (52%), Gaps = 5/137 (3%)
Query: 62 FDITKGRVFVKFMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDL 121
FD R + + E +++ + ++DR+ +G + +G +R +Y +L +
Sbjct: 12 FDWRAVRGALGWGEAHAVDLAHAIIDRHRASGRTALVFIDQQGRE----SRHSYAELAEQ 67
Query: 122 VCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLS 181
+ AN L G+R GDRVA +P E ++ MLA +IGA++ +F GF DA+ RL
Sbjct: 68 SDRAANLLARLGVRPGDRVAGLLPRGPEILVAMLAAIKIGAIYVPIFTGFKRDAIEYRLG 127
Query: 182 DAKAKLLVTADGAWRGE 198
+ A+++ T A RG+
Sbjct: 128 HSGARVVFT-HAALRGQ 143
>UniRef50_A4T5I6 Cluster: Acetoacetyl-CoA synthase; n=2;
Mycobacterium|Rep: Acetoacetyl-CoA synthase -
Mycobacterium gilvum PYR-GCK
Length = 637
Score = 91.9 bits (218), Expect = 5e-17
Identities = 60/203 (29%), Positives = 99/203 (48%), Gaps = 5/203 (2%)
Query: 501 PFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQD--RFERVYFSKFPGYYC 558
P+ GV +EDG + G G LV +P P M D+D R+ YF +PG +
Sbjct: 424 PYLGVALDAWDEDGQPVRGE-VGELVITKPMPSMPVGFWNDRDGSRYRCAYFDTYPGVWR 482
Query: 559 TGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGE 618
GD + + G + + GR D LN G M +A++ + S P V+EA V+ G
Sbjct: 483 HGDWITLTDRGSVVVHGRSDSTLNRHGIRMGSADIYQAVESLPEVAEALVIGAELPDGGY 542
Query: 619 ALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRK 678
+ FVV +G++ D L + +R ++ PD I AP +P TR+GK + ++K
Sbjct: 543 WMPLFVVPADGVKLDDGLRDKINERIRTELSPRHVPDEIIAAPAIPHTRTGKKLEVPIKK 602
Query: 679 IAVGDH--EVGDISTLADPGVVE 699
+ G ++ + S + DP +++
Sbjct: 603 LLQGGDPAKIVERSAVDDPALLD 625
Score = 74.1 bits (174), Expect = 1e-11
Identities = 49/163 (30%), Positives = 77/163 (47%), Gaps = 5/163 (3%)
Query: 271 PEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGW 330
P V + PL+VL++SG+TG PKG+VH G ++ D R DV++ W
Sbjct: 240 PARVPFDHPLWVLFSSGTTGLPKGIVHGHGGVVVEHLKAVALQSDIGRDDVFFWYTSPSW 299
Query: 331 ITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYN 390
+ + V A L AT V ++G+P + W I ++ T T+P + M
Sbjct: 300 MMWNFQV--AGLLVGATIVCYDGSPTARHPETLWEIASRVGATVLGTSPGYVLGCM---K 354
Query: 391 VEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSI 433
E + DLS+LR +G G + A+ LW ++G + SI
Sbjct: 355 AEATPASTYDLSALRSVGITGSALPAASSLWLQDQVGVQVASI 397
Score = 65.7 bits (153), Expect = 4e-09
Identities = 39/110 (35%), Positives = 58/110 (52%), Gaps = 1/110 (0%)
Query: 84 NLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAVY 143
N +D+ +++ D+ A D +++ +LL FA+ L A G+ GDRV Y
Sbjct: 89 NYVDQVMRHVRTDRPAILHVSEDAPD-REVSWAELLGRTAAFADRLRAAGVESGDRVVGY 147
Query: 144 MPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADG 193
+P I EAV+ LA A IGAV + +S+ A +RL + K LV ADG
Sbjct: 148 LPNIPEAVVAFLATASIGAVWSACGQDYSAKAALDRLGQLEPKALVAADG 197
>UniRef50_Q97YK9 Cluster: Acetyl-CoA synthetase; n=4;
Sulfolobus|Rep: Acetyl-CoA synthetase - Sulfolobus
solfataricus
Length = 529
Score = 91.9 bits (218), Expect = 5e-17
Identities = 61/170 (35%), Positives = 84/170 (49%), Gaps = 5/170 (2%)
Query: 504 GVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYCTGDGV 563
G E KI++E+G E+ G L M + R V F ++ TGD
Sbjct: 356 GYEVKIVDENGNEVPPKTVGDLYVKGDSIAMFYWRDYEATRRNMVGF-----WFRTGDKF 410
Query: 564 RRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALYCF 623
RDEDGY + GR DDM+ SG +S EVE VL S P + EAAVV P EV + F
Sbjct: 411 FRDEDGYYYYVGRSDDMIKTSGLWVSPIEVEAVLLSHPAILEAAVVGLPDEVGLIKVVAF 470
Query: 624 VVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMR 673
V LK+G +L + +++K+ + P I+ +PKT +GKI R
Sbjct: 471 VTLKQGYSPSEELANNIKDYLKEKLDHYKVPKEIRFVNEIPKTATGKIQR 520
Score = 78.6 bits (185), Expect = 5e-13
Identities = 92/355 (25%), Positives = 144/355 (40%), Gaps = 35/355 (9%)
Query: 114 TYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSS 173
TYR+L+D + + N L GI K +R+ + + +IGA+ V
Sbjct: 38 TYRRLIDEINRVGNTLKDLGIEKENRILMISYDSPYFISTFYGAVKIGAIPVPVNTYLKP 97
Query: 174 DALAERLSDAKAKLLVTADGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDR 233
+ L D +AK+LV W +I+ T KH + + + N +++
Sbjct: 98 EEYLFFLEDTEAKVLVVEPEIWN---------KLSQSIKNKTTKLKHVIILPGMYNMMEK 148
Query: 234 VTPGGSLKSEIKDLYNWNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPK 293
+ S + + Y E++ S E + D F LYTSG+TG PK
Sbjct: 149 IE---STQYIPQSSYT----------ELVSKASVKLEAEKTSPNDMAFWLYTSGTTGHPK 195
Query: 294 GVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEG 353
+H L+ + + RD + + + + G Y N A+ ++
Sbjct: 196 AALHLHKDILVVLNTFVKNILKITERDRLFSASKLFFAYGLGNGSYFAFGNGASVILM-- 253
Query: 354 TPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEP 413
P + R I+KYK T F+ PT A++ VE+ DLSSLR S GEP
Sbjct: 254 -PERVEPKRVLETIHKYKPTIFFGVPTLYNAML---QVEEWK--NYDLSSLRFCVSAGEP 307
Query: 414 INPAAWLWYYTRIGKERCSIVDTFWQTETGGHVITGLPGATPMKPGAAEKKHPVY 468
+ PA + + R G E IVD TE I+ +PG K G++ K P Y
Sbjct: 308 LPPAIFNRWKERYGIE---IVDGIGSTEALHIYISNIPG--NCKAGSSGKVVPGY 357
>UniRef50_Q8KUH3 Cluster: Polyketide synthase; n=2; Bacteria|Rep:
Polyketide synthase - Actinosynnema pretiosum subsp.
auranticum
Length = 4684
Score = 91.5 bits (217), Expect = 7e-17
Identities = 61/179 (34%), Positives = 94/179 (52%), Gaps = 11/179 (6%)
Query: 499 GFPFFGVEPKILNED-GVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYY 557
G P G+ ++++ D G++ EG + W ++ +R E + G+Y
Sbjct: 329 GLPVPGLAVRLVDPDTGLDAPTGAEGEV-----WVRGPSVMVGYHNRPEATAAALRDGWY 383
Query: 558 CTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKG 617
TGD RDE G+ +TGRIDD++ G + AEVE VL + P V++AAVV +PH+V G
Sbjct: 384 RTGDLATRDESGFHAVTGRIDDVVVRGGEKVHPAEVEAVLRAVPGVADAAVVGRPHDVLG 443
Query: 618 EALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRIL 676
E F+V EG FD V + R+++ P+ + +P+T SGKI RR+L
Sbjct: 444 EVPVAFLVPGEG--FDPAQV---LAVCRERLSYHKVPEELYQIESVPRTASGKITRRVL 497
Score = 36.7 bits (81), Expect = 2.2
Identities = 29/96 (30%), Positives = 42/96 (43%), Gaps = 1/96 (1%)
Query: 259 HEVLEGESNICPP-EWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYH 317
+E L G P + + +D ++LYTSG+TG PKGV+ T L AA + V
Sbjct: 138 YEALAGVDAPLPAHDALELDDLAWMLYTSGTTGAPKGVLSTQRNCLWSVAACYAPVLGLT 197
Query: 318 RRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEG 353
D + H V A A AT+ + +G
Sbjct: 198 PDDRVLWPLPLFHSLSHIAGVLATTAVGATTRVVDG 233
Score = 36.3 bits (80), Expect = 2.9
Identities = 32/97 (32%), Positives = 47/97 (48%), Gaps = 8/97 (8%)
Query: 95 GDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICM 154
GD++AF D +T+ L + A L A+ + GDR + + +E V C
Sbjct: 22 GDRVAF------RDARRAVTWVDLELRTRRLAGHLAARRLLPGDRAVILLGNRVETVECY 75
Query: 155 LACARIGAVHTVVFAGFSSDA-LAERLSDAKAKLLVT 190
LA R GAV V S+DA L L D+ A+L++T
Sbjct: 76 LALVRAGAV-GVPLNPVSTDAELGALLDDSGARLVLT 111
>UniRef50_Q83DG9 Cluster: Acetoacetyl-CoA synthase; n=5;
Gammaproteobacteria|Rep: Acetoacetyl-CoA synthase -
Coxiella burnetii
Length = 650
Score = 91.1 bits (216), Expect = 9e-17
Identities = 64/204 (31%), Positives = 102/204 (50%), Gaps = 9/204 (4%)
Query: 504 GVEPKILNEDGVE-IEGPGEGYLVFARPWPGMMRTLLEDQD--RFERVYFSKFPGYYCTG 560
G++ KI N+DG IE GE LV P+P M D + ++ + YF K+P + G
Sbjct: 447 GMDVKIFNDDGDSVIEEKGE--LVCKSPFPSMPIYFWNDPEGKKYHQAYFDKYPNTWAHG 504
Query: 561 DGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKG-EA 619
D + + G L I GR D LN G + TAE+ + + + V + + KG E
Sbjct: 505 DYAKTTKRGTLIIYGRSDTTLNPGGIRIGTAEIYQQVEKIKEILDCLVTSQ--QWKGDER 562
Query: 620 LYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKI 679
+ FVVL++ L K + +RQ + P+ I P LP+T+SGKI+ ++KI
Sbjct: 563 IILFVVLQKETTLTDPLRKKIQTTIRQNLSPHHVPNKIIAVPDLPRTKSGKIVELAVKKI 622
Query: 680 AVGDHEVGDISTLADPGVVEELFN 703
G+ V +++ L +P ++E N
Sbjct: 623 INGE-SVNNLTALENPKILEYFQN 645
Score = 89.4 bits (212), Expect = 3e-16
Identities = 96/415 (23%), Positives = 169/415 (40%), Gaps = 34/415 (8%)
Query: 13 IKKSYLPSIQKYKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRVFVK 72
I K + I+ Y +Y+ S+ + LFW V + P + + + + F+
Sbjct: 27 INKRFSLKIEGYPALYQWSIDQPALFWKAVWDFCGISASQAPTNVLVRGKRMEESQWFLG 86
Query: 73 FMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTR-ITYRKLLDLVCQFANGLLA 131
A+LN NLL +N +A + S ++R ITY +L V A L
Sbjct: 87 ----AKLNFAENLLRHRNQN-----VALIF--TSETGFSRSITYAELYTEVAALAGFLRQ 135
Query: 132 KGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTA 191
+ GDRV + +E VI MLA A +GA+ + F + L +R K K+L
Sbjct: 136 CHVVPGDRVVGVLSNQIETVIAMLATASVGAIWSACSPDFGLEGLVDRFGQIKPKVLFAV 195
Query: 192 DGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWN 251
D + YK ++K R + + + + P I +L N +
Sbjct: 196 DS-------HTYKGKTYHHLDKIRQLQQQLTSLTHTI-----IVPNHQKNIAINELKNAS 243
Query: 252 EETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFR 311
D L S E + + P+++LY+SG+TGKPK +VH+ G L+
Sbjct: 244 LYPDC-----LRATSLPFYFEALPFDHPVYILYSSGTTGKPKCMVHSAGGTLLQHLKELI 298
Query: 312 YVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYK 371
D + W+ + + + LA AT V+++G P++P + +I+K
Sbjct: 299 LHTDLRPSQRIFFYTTCSWMMWNW--LMSSLAVGATVVLYDGAPFYPTPTALFDLIDKVG 356
Query: 372 VTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRI 426
++ F + + V +L SL+ + + G P+ P ++ + Y +
Sbjct: 357 ISIFGVGAKILESAEKFDLVPK---KTHNLLSLKTILTTGSPLLPKSFDYVYNNV 408
>UniRef50_Q12HA7 Cluster: Acetoacetyl-CoA synthase precursor; n=6;
Proteobacteria|Rep: Acetoacetyl-CoA synthase precursor -
Polaromonas sp. (strain JS666 / ATCC BAA-500)
Length = 696
Score = 91.1 bits (216), Expect = 9e-17
Identities = 104/416 (25%), Positives = 172/416 (41%), Gaps = 41/416 (9%)
Query: 20 SIQKYKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRVFVKFMEEAEL 79
S Y ++ S+T+ E FW + F+ +P P + + + R F A++
Sbjct: 23 SFDSYDALWRWSVTDLEAFWQSIWDYFELQ-SPTPHTAVLADRRMPGARWF----PGAQV 77
Query: 80 NVCYNLL---DRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRK 136
N +L D+ GF + + + + +++ L V A L A+G+
Sbjct: 78 NYARQVLRHVDKAHAAGFPALVNHNEKSLASGQHRELSWPALRQQVASLALHLKAQGVEP 137
Query: 137 GDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWR 196
GDRVA Y+P I EA++ LA IG V ++ + A+ +R + K+L+ DG
Sbjct: 138 GDRVAAYLPNIPEAMVAFLAVVSIGGVWSICAPDMGTHAVLDRFKQIEPKVLIACDGVRY 197
Query: 197 GERMYVYKRTCDDA-IEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETD 255
G R + RT A + A +H V+ H + GS S I D T
Sbjct: 198 GGR--DFDRTAVLAELRAALPSLQH------VIVHENL----GSTNS-IADSTLLESAT- 243
Query: 256 IWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFD 315
+ ++ P W+ + PL+++Y+SG+TG PK +VH G + A A D
Sbjct: 244 ----ARNDAQTAAFEPLWLPFDHPLWIVYSSGTTGLPKPIVHGHGGTQLVALALKTLHND 299
Query: 316 ----YHRR---DVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIIN 368
Y + Y + GW+ + + + L N T +F+G P K W+ +
Sbjct: 300 IGCSYEANSWGERYHWYSSTGWVMWNAQL--SGLLNGTTCCLFDGNPGGSKDKPDWTTLW 357
Query: 369 KYKV---TQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLW 421
++ F+ A A A VE DL+ +R LGS G P++ W
Sbjct: 358 RFAADLDVTFFGAGAAFFANCMKAGVELAE--CGDLTRIRALGSTGSPLSEDTQRW 411
Score = 72.5 bits (170), Expect = 4e-11
Identities = 50/177 (28%), Positives = 84/177 (47%), Gaps = 4/177 (2%)
Query: 523 GYLVFARPWPGMMRTLLEDQ--DRFERVYFSKFPGYYCTGDGVRRDEDGYLWITGRIDDM 580
G LV +P P M + D+ R+ YF +P + GD ++ +G I GR D
Sbjct: 501 GELVCTQPLPSMPLYFVGDEGNQRYLSSYFDIYPNVWRHGDWLKIGANGGCVIYGRSDAT 560
Query: 581 LNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALYCFVVLKEGLQFDADLVKTL 640
+N G M T+E+ + + P V ++ VV + + + FVVL+EG+ D L L
Sbjct: 561 INRHGLRMGTSELYSAIEALPEVLDSMVVDLEYLGRESYMPLFVVLREGVALDDALKARL 620
Query: 641 TLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKIAVGD--HEVGDISTLADP 695
++ + PD I P +P+T SGK ++K+ +G +V + +A+P
Sbjct: 621 NGAIKTALSPRFVPDAIFQVPEIPRTLSGKKQELPIKKLLLGQPIEKVVNRDAMANP 677
>UniRef50_Q5YX39 Cluster: Putative acyl-CoA synthetase; n=1;
Nocardia farcinica|Rep: Putative acyl-CoA synthetase -
Nocardia farcinica
Length = 543
Score = 90.6 bits (215), Expect = 1e-16
Identities = 63/185 (34%), Positives = 96/185 (51%), Gaps = 9/185 (4%)
Query: 498 RGFPFFGVEPKILNEDGVEIEGPGE-GYLVFARPWPGMMRTLLEDQDRF-ERVYFSKFPG 555
R FP F V +L++ G PGE G + A PG E+V+ G
Sbjct: 363 RAFPGFTVT--VLDDTGAPAP-PGETGEICVAAGNPGQFLGYWNQPGTTAEKVH----DG 415
Query: 556 YYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEV 615
+ TGD R D G LW GR+DD+++ +G+ + E+E L + P V+ AAV+ P ++
Sbjct: 416 WIHTGDLGRADTAGNLWYQGRLDDVISSAGYRIGPGEIEECLLTHPAVAMAAVIGVPDDL 475
Query: 616 KGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRI 675
+GEA++ FVV +G+ DL + L V+ ++ + P I LP T +GKI+RR
Sbjct: 476 RGEAVHAFVVPTDGVTGTDDLRRALQDHVKSRLAFYQYPRRITFLDELPMTTTGKILRRE 535
Query: 676 LRKIA 680
LR +A
Sbjct: 536 LRHLA 540
Score = 62.9 bits (146), Expect = 3e-08
Identities = 46/153 (30%), Positives = 72/153 (47%), Gaps = 10/153 (6%)
Query: 277 EDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRR--DVYWCTADVGWITGH 334
+ P ++YTSG+TG+PKG +H L + R F+ + DV+W AD WI G
Sbjct: 187 DTPAIIIYTSGTTGRPKGALHGHRVLLAHMPGV-RTAFENAPQPGDVFWTPADWAWIGGL 245
Query: 335 TYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDG 394
V++ LA V G + P DR +++ +++T + PTA++ M V+
Sbjct: 246 FDVLFPALALGCPVVATPGA-FTP--DRALAVMRAHRITAAFLPPTALKQ-MRSAGVDRA 301
Query: 395 NLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIG 427
T + LR L S GE + A W + G
Sbjct: 302 AATG---THLRALASGGESLGQALQHWVHDTFG 331
Score = 50.0 bits (114), Expect = 2e-04
Identities = 29/82 (35%), Positives = 43/82 (52%)
Query: 108 DDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVV 167
D TR ++ ++ L +FA L G+ GDR+ V +P LE + L R G V +
Sbjct: 49 DTSTRHSFGEVAALSRRFAAALREFGLAAGDRIGVMVPQGLEVLTAHLGAFRAGMVTVPL 108
Query: 168 FAGFSSDALAERLSDAKAKLLV 189
F DA+A RL D+ A++LV
Sbjct: 109 SVKFGGDAVAHRLRDSGARVLV 130
>UniRef50_A0Z8S4 Cluster: Acyl-CoA synthase; n=1; marine gamma
proteobacterium HTCC2080|Rep: Acyl-CoA synthase - marine
gamma proteobacterium HTCC2080
Length = 520
Score = 90.6 bits (215), Expect = 1e-16
Identities = 58/175 (33%), Positives = 85/175 (48%), Gaps = 8/175 (4%)
Query: 504 GVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYCTGDGV 563
G E KI++ +GVE+ GP + + R M+ Q E + G+ TGD
Sbjct: 343 GNEVKIVDTEGVEL-GPNQTGEICLRSASNMLEYFNRSQATAETL----LDGWVMTGDAG 397
Query: 564 RRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALYCF 623
DE+GY+++ R+ DM+ G + EVE VL+ P V E AV+ P E GEAL
Sbjct: 398 TIDEEGYIYLRDRLKDMVVTGGENVYPVEVENVLSGIPGVIEVAVIGIPDETYGEALLAI 457
Query: 624 VVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRK 678
L+ DAD + R K+ F P ++ P LP+ SGKI++ LR+
Sbjct: 458 FALQPNHMIDAD---DVIAFCRDKLAGFKIPRRVECIPALPRNPSGKILKTTLRE 509
Score = 40.3 bits (90), Expect = 0.18
Identities = 53/179 (29%), Positives = 69/179 (38%), Gaps = 13/179 (7%)
Query: 274 VAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITG 333
V P LYTSG+TGKPKG V + L + D + G
Sbjct: 154 VDEHSPALQLYTSGTTGKPKGAVLSHRNILSLTQMMGIANDGAYNADTINLVVAPLFHIG 213
Query: 334 HTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHY-NVE 392
T V Y LA A +++ E + P R I VT + P I+A++ NV
Sbjct: 214 GTGVAYIGLAYGAHNILHEA--FDPL--RVVETIQAQSVTSMFMVPAMIQAIVKLVPNVR 269
Query: 393 DGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTETGGHVITGLP 451
D D SSL + PI+ A L + R S V + TET G VI P
Sbjct: 270 D-----YDFSSLENIAYGASPIS-ATLLKEALEVFDSRFSQV--YGMTETSGTVIALSP 320
>UniRef50_Q7KWS0 Cluster: Similar to Rhizobium loti (Mesorhizobium
loti). Acetyl-CoA synthetase; n=4; Dictyostelium
discoideum|Rep: Similar to Rhizobium loti (Mesorhizobium
loti). Acetyl-CoA synthetase - Dictyostelium discoideum
(Slime mold)
Length = 637
Score = 90.6 bits (215), Expect = 1e-16
Identities = 58/186 (31%), Positives = 90/186 (48%), Gaps = 5/186 (2%)
Query: 495 NRTRGFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFP 554
N + G P G +I++ +G+ + G + P P T + ++ K
Sbjct: 452 NGSIGKPIPGHIVEIIDSNGMILPIDQVGDIALKTPDPVAFLTYWNNDKAAKK----KMN 507
Query: 555 G-YYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPH 613
G + TGD R+D DGY+W GR DD++N SG+ + +E+E L P VS VV P
Sbjct: 508 GDWLVTGDLGRKDSDGYIWYVGRDDDIINSSGYRIGPSEIENCLLKHPSVSNVGVVGVPD 567
Query: 614 EVKGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMR 673
E++GE + F+VL L K + V+ + A P I+ LP T +GKI+R
Sbjct: 568 EIRGEIVKAFIVLNPSYSKSDQLKKDIQNYVKTILSAHEYPREIEFINELPTTTTGKIIR 627
Query: 674 RILRKI 679
+ LR +
Sbjct: 628 KDLRSL 633
Score = 56.8 bits (131), Expect = 2e-06
Identities = 76/349 (21%), Positives = 140/349 (40%), Gaps = 41/349 (11%)
Query: 124 QFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDA 183
Q AN G++K DRV V + E + R G + +F F AL RLS++
Sbjct: 147 QLANKYKEIGLKKRDRVGVLLSQGFECALSHTTTLRSGMITMPLFTLFGPKALEFRLSNS 206
Query: 184 KAKLLVTADGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSE 243
++ T + +EK + + + +L ++ G+L
Sbjct: 207 STSCVL----------------TDLENLEKL-------LGILPCLPNLKKIIVFGTLSEN 243
Query: 244 IKDLYNWNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYL 303
K+ ++ + W ++ E S ++D +++TSG+TG PKG +H L
Sbjct: 244 FKNNSHYGNLIEEWNDKISENYSKEFEAIKSKSDDEAVIIFTSGTTGNPKGCLHAHRVLL 303
Query: 304 MYAAATFRYVFDYHRRD-----VYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFP 358
+ ++ R +++ AD WI G V+ L T + T + P
Sbjct: 304 GHLPGVQFPQNNFPNRKSTNDYIFYTPADWAWIGGLFDVLIPSLYYGVTVLAHRMTKFEP 363
Query: 359 KVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAA 418
K + ++ KV + P+A++ + E LT +++S +GS GE +
Sbjct: 364 K--KICKLLIDNKVDTAFLPPSALKIM--KQQEEQLKLTPVNMTS---IGSGGESLGEKL 416
Query: 419 WLWYYTRIGKERCSIVDTFWQTETGGHVITG-LPGATPMKPGAAEKKHP 466
W GKE+ ++ + +T +++ G P P+K G+ K P
Sbjct: 417 LQW-----GKEQFNVEIAEFYGQTEANLLVGNCPSVFPIKNGSIGKPIP 460
>UniRef50_UPI000155F3B9 Cluster: PREDICTED: hypothetical protein;
n=1; Equus caballus|Rep: PREDICTED: hypothetical protein
- Equus caballus
Length = 301
Score = 90.2 bits (214), Expect = 2e-16
Identities = 50/137 (36%), Positives = 70/137 (51%), Gaps = 2/137 (1%)
Query: 543 DRFERVYFSKFPGYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPR 602
D E+ S+ +Y TGD R D+DGY W GR DD++N + + + EVE LA P
Sbjct: 159 DNPEKTAASEQGDFYITGDRARMDKDGYFWFMGRNDDVINSASYRIGPVEVESALAEHPA 218
Query: 603 VSEAAVVPKPHEVKGEALYCFVVLKEGLQF--DADLVKTLTLLVRQKIGAFAAPDTIQNA 660
V E+AVV P ++GE + F+VL +L + L V++ + P +
Sbjct: 219 VLESAVVSSPDPIRGEVVKAFIVLSPAYSSHDPEELTRELQEHVKRVTAPYKYPRKVAFV 278
Query: 661 PGLPKTRSGKIMRRILR 677
LPKT SGKI R LR
Sbjct: 279 SELPKTVSGKIQRSKLR 295
>UniRef50_Q89DS2 Cluster: Acetyl-coenzyme A synthetase; n=1;
Bradyrhizobium japonicum|Rep: Acetyl-coenzyme A
synthetase - Bradyrhizobium japonicum
Length = 562
Score = 90.2 bits (214), Expect = 2e-16
Identities = 52/174 (29%), Positives = 87/174 (50%), Gaps = 3/174 (1%)
Query: 504 GVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYCTGDGV 563
G + +I+N+ G E G + +P P M + + + Y F TGD
Sbjct: 389 GFDVRIVNDKGEEQPRGQRGIIGVRQPCPVTMLEYWRNPEATRKKYAGDF---LLTGDLG 445
Query: 564 RRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALYCF 623
+DEDGY W R DD++ +G+ + +E+E L P V+ AAVV P ++ E++ +
Sbjct: 446 VQDEDGYFWYVSREDDVITTAGYRVGPSEIEHTLMKHPSVAMAAVVGIPDPIRTESIKAW 505
Query: 624 VVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILR 677
+VL+ G L + + V+ ++ A P ++ A LP T +GK++RR LR
Sbjct: 506 IVLRPGFTGSDALAREIQEFVKVQLAAHEYPRFVEFAETLPMTATGKVLRRELR 559
Score = 66.9 bits (156), Expect = 2e-09
Identities = 39/119 (32%), Positives = 65/119 (54%), Gaps = 3/119 (2%)
Query: 77 AELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRK 136
A N+ DR+ +G G + + N TR ++ ++ ++ +FAN L A G+ +
Sbjct: 47 ARFNMAEACCDRHA-DGTGRLALIYVDENGAT--TRTSFDEVAEMSRRFANVLKADGLAR 103
Query: 137 GDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAW 195
GDRVAV++ LE I +A R G + +FA F DAL RLS+++A+ ++T + W
Sbjct: 104 GDRVAVFLSQSLELPIAHMAAFRSGLISIPLFALFGEDALEFRLSNSQARAIITDEAGW 162
Score = 48.0 bits (109), Expect = 9e-04
Identities = 50/193 (25%), Positives = 77/193 (39%), Gaps = 14/193 (7%)
Query: 275 AAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAA-ATFRYVFDYHRRDVYWCTADVGWITG 333
+A+DP ++YTSG+TG PKG +H L + + F D+ W AD WI G
Sbjct: 209 SADDPALIIYTSGTTGNPKGALHAHRVVLGHLPNVEMCHNFLPRPGDLMWTPADWAWIGG 268
Query: 334 HTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVED 393
+ A + V + P+ ++ V + PTA++ LM V+
Sbjct: 269 LVNGLLAFWYHGIPLVGHRARKFEPQA--AMQMMADLSVRNVFLPPTALK-LMRQAGVKH 325
Query: 394 GNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTETGGHVITGLPGA 453
+ LR + + GE + W G + + F QTE VI
Sbjct: 326 PGV------KLRSIFTGGESLGGELLGWVRETFGIDAHEV---FGQTEC-NLVIGSNSNL 375
Query: 454 TPMKPGAAEKKHP 466
P++PGA K P
Sbjct: 376 FPIRPGAMGKATP 388
>UniRef50_A3VKE9 Cluster: Acyl-CoA synthase; n=5;
Proteobacteria|Rep: Acyl-CoA synthase - Rhodobacterales
bacterium HTCC2654
Length = 523
Score = 90.2 bits (214), Expect = 2e-16
Identities = 58/194 (29%), Positives = 97/194 (50%), Gaps = 8/194 (4%)
Query: 484 TVMIVHLPNKSNRTRGFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQD 543
TV+ H + + G P + VE ++++ED ++ PGE + R P ++ + +
Sbjct: 330 TVLYPHEHEERPASAGRPIYNVETRLVDEDMNDV-APGEQGEIVHRS-PQLLSGYWDKAE 387
Query: 544 RFERVYFSKFPGYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRV 603
E + G++ +GD DE GY+ + R D++ G ++++ EVE VL + P V
Sbjct: 388 ATEEAFAG---GWFHSGDVGVMDEAGYITVVDRTKDIIKTGGTMVASREVEEVLFTHPAV 444
Query: 604 SEAAVVPKPHEVKGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGL 663
SE AV+ PH EA+ VVL+EG + D L + + F P + A L
Sbjct: 445 SEVAVIALPHPKWVEAVTAVVVLREGAEASED---DLIAFAKDNLAPFKLPKRVLFASEL 501
Query: 664 PKTRSGKIMRRILR 677
P+ +GKI++R LR
Sbjct: 502 PRNTAGKILKRTLR 515
Score = 35.5 bits (78), Expect = 5.0
Identities = 25/75 (33%), Positives = 33/75 (44%)
Query: 114 TYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSS 173
T+ L D + A LL G+ GDRVA Y ++ LACAR G +H +
Sbjct: 42 TFTGLYDGAGRIAARLLEAGLVPGDRVAAYGRNSDAYLLLYLACARAGFIHVPINYALVG 101
Query: 174 DALAERLSDAKAKLL 188
LA L + A L
Sbjct: 102 RELAYILDNCGADAL 116
>UniRef50_A1VP64 Cluster: Acetoacetyl-CoA synthase; n=2;
Comamonadaceae|Rep: Acetoacetyl-CoA synthase -
Polaromonas naphthalenivorans (strain CJ2)
Length = 667
Score = 90.2 bits (214), Expect = 2e-16
Identities = 79/315 (25%), Positives = 133/315 (42%), Gaps = 25/315 (7%)
Query: 113 ITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFS 172
I++ +L A L + G++ GDRVA +MP + E VI LACA +GA+ +
Sbjct: 124 ISWEELERTTAALAAQLRSWGVQPGDRVASFMPNLPETVIAFLACASVGAIWSSCAPDMG 183
Query: 173 SDALAERLSDAKAKLLVTADGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLD 232
++ + +RL + K+L D Y Y D R+ + ++ + +
Sbjct: 184 ANVVLDRLRQIEPKVLFATDS-------YSYNGKNHD-----RSVVVN--ELLAGLPSVQ 229
Query: 233 RVTPGGSLKSEIKDLYNWNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKP 292
RV + L W W + + G + E + PL++LY+SG+TG P
Sbjct: 230 RVVQVSGPLDGSRPL-PWRNHCS--WQDCVAGSATP-RYERLPFSHPLWILYSSGTTGLP 285
Query: 293 KGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFE 352
K +VH+ G ++ + D D GW + V L + A+ V+++
Sbjct: 286 KAIVHSHGGIVLTHLKSMALQNDLRPGDRLMFLGSTGWAVWNLQV--GALLSGASIVLYD 343
Query: 353 GTPYFPKVDRYWSIINKYKVTQF-YTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVG 411
G P +P D W ++++ VTQ A I + D LS LR + S G
Sbjct: 344 GNPAWPTGDALWRFMDEHGVTQLGCGAAYLINCMKDGVRPRD----FAKLSKLRTILSTG 399
Query: 412 EPINPAAWLWYYTRI 426
P++ A+ W Y +
Sbjct: 400 SPLSMDAYHWVYDAV 414
Score = 81.0 bits (191), Expect = 1e-13
Identities = 52/162 (32%), Positives = 76/162 (46%), Gaps = 2/162 (1%)
Query: 523 GYLVFARPWPGMMRTLLED--QDRFERVYFSKFPGYYCTGDGVRRDEDGYLWITGRIDDM 580
G LV +P P M D R+ YF +PG + GD +R E G I GR D
Sbjct: 471 GELVITQPMPSMPLYFWNDTGNKRYLESYFETYPGLWRQGDWIRFTEHGSAVIYGRSDST 530
Query: 581 LNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALYCFVVLKEGLQFDADLVKTL 640
+N G M TAE+ V+ P V ++ V+ + + FVVL+ G FD L + +
Sbjct: 531 INRFGIRMGTAEIYRVVEEMPEVRDSLVIDLEFLGRPSFMPLFVVLQPGAVFDEVLQERI 590
Query: 641 TLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKIAVG 682
+R K A P+ + +P+T SGK M +RK+ +G
Sbjct: 591 KHQIRSKASARHVPNEVVQVTEIPRTLSGKKMEVPVRKLLLG 632
>UniRef50_Q86JR9 Cluster: Putative uncharacterized protein; n=2;
Dictyostelium discoideum|Rep: Putative uncharacterized
protein - Dictyostelium discoideum (Slime mold)
Length = 400
Score = 90.2 bits (214), Expect = 2e-16
Identities = 65/223 (29%), Positives = 110/223 (49%), Gaps = 11/223 (4%)
Query: 95 GDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICM 154
GD+ A +E ++TY +L + VC+F+ LL I K D V +YM +EA I +
Sbjct: 55 GDQDALIYECPYLKKTVKLTYHQLYEKVCEFSRVLLNLNISKNDNVLIYMANTVEAPIAI 114
Query: 155 LACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGERMYVYKRTCDDAIEKA 214
L+C GA H V+F G+S +L +R+ KL++T + + + + ++IE +
Sbjct: 115 LSCTHNGATHCVLFDGYSVKSLIDRIETITPKLIITTNYGIFNDGIINFITNLKESIELS 174
Query: 215 RTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIWWHEVLEGESNICPP--E 272
TF V + + +T LK ++KD+ T W+ E + + N P E
Sbjct: 175 -TFKPSNV----ITLFRNDITSESDLK-KVKDIPT-IPNTLSWYDENKKLKENNQSPFYE 227
Query: 273 WVAAED--PLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYV 313
+V E PL+++Y+SG+TG K VV + L+ +Y+
Sbjct: 228 YVPVESSHPLYIIYSSGTTGNAKAVVRSNGPNLVCGIIKNKYI 270
>UniRef50_Q5CD72 Cluster: Acyl-CoA synthetase; n=3;
Pseudomonadales|Rep: Acyl-CoA synthetase - Pseudomonas
chlororaphis (Pseudomonas aureofaciens)
Length = 545
Score = 89.0 bits (211), Expect = 4e-16
Identities = 49/122 (40%), Positives = 68/122 (55%)
Query: 556 YYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEV 615
YY +GD V ++DG + GR DD++ SG+ + +VE L P V EAAV+ KP
Sbjct: 413 YYLSGDIVELNDDGSISFVGRNDDLITTSGYRVGPFDVESALIEHPAVVEAAVIGKPDPQ 472
Query: 616 KGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRI 675
+ E + FVVL +L + L L VRQ++ A A P ++ LPKT SGK+ R I
Sbjct: 473 RTELIKAFVVLNTPYLPSPELAEELRLHVRQRLAAHAYPREMEFVDHLPKTPSGKLQRFI 532
Query: 676 LR 677
LR
Sbjct: 533 LR 534
Score = 78.6 bits (185), Expect = 5e-13
Identities = 62/212 (29%), Positives = 95/212 (44%), Gaps = 12/212 (5%)
Query: 257 WWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDY 316
+W L +++ C P + A P ++ TSG+TG K + + L + R D
Sbjct: 167 FW-SALNRQADDCAPVLLDASAPFLLMCTSGTTGPAKPLEVPLSAILAFKGY-MRDAIDL 224
Query: 317 HRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFY 376
D +W AD GW G Y V PLA ++ ++G P+ + R+ II KY +
Sbjct: 225 RADDRFWNLADPGWAYGLYYAVTGPLACGYATLFYDG-PFTVESTRH--IIAKYAINNLA 281
Query: 377 TAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDT 436
+PTA R L+A E + LR + S GEP+NP W+ ++G I D
Sbjct: 282 GSPTAYRFLIA-AGAEFADAVR---GRLRAVSSAGEPLNPQVVRWFAEQLG---VVIHDH 334
Query: 437 FWQTETGGHVITGLPGATPMKPGAAEKKHPVY 468
+ QTE G + P++ G+A P Y
Sbjct: 335 YGQTEIGMVLCNHHGLRHPVREGSAGYAVPGY 366
Score = 65.3 bits (152), Expect = 5e-09
Identities = 39/116 (33%), Positives = 59/116 (50%), Gaps = 4/116 (3%)
Query: 75 EEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGI 134
E LN C DR+ G+ +A + E R +R L +F N L +G+
Sbjct: 24 ELTALNACVECCDRHAH---GEAVALYCEAQD-GHAERYRFRDLQRQAARFGNFLREQGV 79
Query: 135 RKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVT 190
+ GDRVA MP +E +I +L RIGAV+ +F F A+ +RL+ + A+ +VT
Sbjct: 80 KPGDRVAGLMPRTVELLIAILGTWRIGAVYQPLFTAFGPKAIEQRLNCSNARWIVT 135
>UniRef50_Q0SGA4 Cluster: Acetate--CoA ligase; n=2;
Corynebacterineae|Rep: Acetate--CoA ligase - Rhodococcus
sp. (strain RHA1)
Length = 546
Score = 89.0 bits (211), Expect = 4e-16
Identities = 48/125 (38%), Positives = 68/125 (54%)
Query: 557 YCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVK 616
+ T D D +G I GR DDM+ SGH +S EVE L P V++AA V ++
Sbjct: 421 FLTEDRAVTDPEGRWQILGRDDDMIIASGHNISPVEVENALLQHPAVADAAAVAYDDPIR 480
Query: 617 GEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRIL 676
G + VV + D+DLV LT LV Q++G +AAP + P LP+T GK+ R +
Sbjct: 481 GGVVRAVVVRADTRADDSDLVTQLTHLVAQRVGPYAAPKVVDFRPDLPRTEVGKLRRAAV 540
Query: 677 RKIAV 681
R++ V
Sbjct: 541 RELPV 545
Score = 71.3 bits (167), Expect = 8e-11
Identities = 83/306 (27%), Positives = 130/306 (42%), Gaps = 42/306 (13%)
Query: 112 RITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGF 171
R TYR+L L + A G+++GDRV + +E+ I +A R G V+ +F GF
Sbjct: 61 RWTYRELDRLAAKAARVFARAGLKRGDRVGGLLSRQVESWITAIAVWRSGLVYVPLFGGF 120
Query: 172 SSDALAERLSDAKAKLLVTADGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHL 231
+ DA+ RL A G R V + A+ +A+ H +D + V
Sbjct: 121 APDAIGLRLDAA-------------GVRAVVVDQQYRPALAQAQA--THGLDPAVFVV-- 163
Query: 232 DRVTPGGSLKSEIKDLYNWNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGK 291
G + + D W E ++G P A D +L+TSG++G
Sbjct: 164 ------GDVAAGTGDRSFWTE---------IDGADADGPLATTALGDAATLLFTSGTSGT 208
Query: 292 PKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMF 351
PK T A ++ + V R V + T+D W G A +A VM+
Sbjct: 209 PKACTMTHATFVSVMPYA-KSVLGATRGSVVFSTSDPAWAFGLYSTGAAVMALGVPRVMY 267
Query: 352 EGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVG 411
G + P + + +I + K T TAP A+R L A + +DG +P +LR + + G
Sbjct: 268 SG-KFVP--EAWHRVIREEKATILTTAPAALRRLTATF-AQDG---VP--PTLRTVAAAG 318
Query: 412 EPINPA 417
EP+ A
Sbjct: 319 EPLTAA 324
>UniRef50_A0FSJ3 Cluster: AMP-dependent synthetase and ligase; n=2;
Proteobacteria|Rep: AMP-dependent synthetase and ligase
- Burkholderia phymatum STM815
Length = 506
Score = 88.6 bits (210), Expect = 5e-16
Identities = 50/127 (39%), Positives = 72/127 (56%), Gaps = 3/127 (2%)
Query: 555 GYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHE 614
G+ TGD DE+G+++I R+ DM+ G + AE+E VL P ++ AAVV P +
Sbjct: 382 GWLHTGDLAYIDEEGFIFIVDRLKDMVITGGFNIYPAELERVLCEHPSIALAAVVGVPDD 441
Query: 615 VKGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRR 674
+KGE F+V K G + + V RQ++ A+ P I+ LPKT SGKI+RR
Sbjct: 442 IKGELAKAFIVRKHGAEIRTEDVFE---FCRQRLAAYKVPRLIEFVEDLPKTNSGKILRR 498
Query: 675 ILRKIAV 681
LRK A+
Sbjct: 499 ELRKKAL 505
>UniRef50_Q2GYG4 Cluster: Putative uncharacterized protein; n=1;
Chaetomium globosum|Rep: Putative uncharacterized
protein - Chaetomium globosum (Soil fungus)
Length = 494
Score = 88.6 bits (210), Expect = 5e-16
Identities = 59/173 (34%), Positives = 87/173 (50%), Gaps = 7/173 (4%)
Query: 504 GVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYCTGDGV 563
GVE IL+ G + EG + + L + + Y ++ GY+ TGD
Sbjct: 316 GVEVVILDGAGAAVRPGAEGEICIRGE--NVTGGYLNNAEANRTSYTAE--GYFRTGDQG 371
Query: 564 RRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALYCF 623
R+D DGYL ITGRI +++N G +S E++ VL P VSEA P E+ G+ +
Sbjct: 372 RKDPDGYLIITGRIKELINKGGEKISPIELDNVLTRHPAVSEAVSFAIPDEMFGQEIGVA 431
Query: 624 VVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRIL 676
VVLK G++ +K V +K+ F P + +PKT +GKI RRI+
Sbjct: 432 VVLKPGVRLAEAELKA---WVAEKLAKFKVPKKVYFTDVMPKTATGKIQRRIV 481
Score = 35.5 bits (78), Expect = 5.0
Identities = 20/84 (23%), Positives = 38/84 (45%)
Query: 113 ITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFS 172
+TY+ L+ F L A GI KG V++ E ++ LA + A+ + +
Sbjct: 30 VTYKDLVSETASFQQKLAAIGIAKGAPVSIATVNSYEFIVSFLAASWQRAIAAPLNPAYK 89
Query: 173 SDALAERLSDAKAKLLVTADGAWR 196
D + D K+ +++ GA++
Sbjct: 90 QDEFEFYIDDVKSAIVLVPKGAYQ 113
>UniRef50_O29286 Cluster: Acetyl-CoA synthetase; n=1; Archaeoglobus
fulgidus|Rep: Acetyl-CoA synthetase - Archaeoglobus
fulgidus
Length = 551
Score = 88.6 bits (210), Expect = 5e-16
Identities = 59/184 (32%), Positives = 94/184 (51%), Gaps = 5/184 (2%)
Query: 499 GFPFFGVEPKILN-EDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYY 557
GFP G KI++ E G E G L P G+ +D E+ S G+
Sbjct: 367 GFPVPGYIAKIVDPETGKECGADEVGSLYIKGP-TGIRYWNHPSRDLSEKQAKSVKNGWN 425
Query: 558 CTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAV--VPKPHEV 615
GD VR+DE+GY++ R DD++ SG+ + E+E L + P V+E AV VP P +
Sbjct: 426 VLGDFVRKDENGYIYFVSRDDDLIKSSGYRIGPDEIEQPLNTHPAVAECAVIGVPDPEGI 485
Query: 616 KGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQ-NAPGLPKTRSGKIMRR 674
+G+ + + LKEG D L + + + + I + P I+ LP+T +GK++RR
Sbjct: 486 RGQVVKAIIRLKEGYTPDEKLKEDILAFLEKHIAKYKLPRIIEFTDKPLPRTPTGKLLRR 545
Query: 675 ILRK 678
+L++
Sbjct: 546 LLKQ 549
Score = 58.8 bits (136), Expect = 5e-07
Identities = 52/189 (27%), Positives = 88/189 (46%), Gaps = 12/189 (6%)
Query: 232 DRVTPG-GSLKSEIKD-----LYNWNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYT 285
+RV P +K EIK + + +E I + EV ES P + P +LYT
Sbjct: 141 ERVFPAVNEVKDEIKTAKAMVVMDGEKEGFIPFSEVT-AESAKFDPILLKIGTPALILYT 199
Query: 286 SGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANA 345
SG+TG PKG VH + ++V+ DV A V + G+ P +
Sbjct: 200 SGTTGLPKGCVHFVENVISSVYLVGKHVWKLTPDDVVGGPAPVSFAMGYGNGCLIPYFHG 259
Query: 346 ATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLR 405
A + ++ P F V+ ++ + ++ +T F + PT+ R ++A +E+ + D+SSLR
Sbjct: 260 AAASIW---PRF-SVENFFKYVEEHGITVFSSLPTSYRMILADPKLEE-YMNKYDISSLR 314
Query: 406 VLGSVGEPI 414
+ GE +
Sbjct: 315 LFTGGGEAL 323
Score = 51.6 bits (118), Expect = 7e-05
Identities = 31/89 (34%), Positives = 46/89 (51%), Gaps = 6/89 (6%)
Query: 75 EEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGI 134
E ELN+ LLDRN++ G G K+A ++E R+TYR L L + AN L+ G+
Sbjct: 28 ERKELNLAEELLDRNIREGRGRKVAVYFEDR------RVTYRDLYRLSNKIANFLVGIGV 81
Query: 135 RKGDRVAVYMPMILEAVICMLACARIGAV 163
+ DRV + EA+ + GA+
Sbjct: 82 QPYDRVGFRTRNMPEAIAVNFGIMKAGAI 110
>UniRef50_A7BL94 Cluster: Beta-ketoacyl synthase; n=1; Beggiatoa sp.
SS|Rep: Beta-ketoacyl synthase - Beggiatoa sp. SS
Length = 552
Score = 88.2 bits (209), Expect = 7e-16
Identities = 60/176 (34%), Positives = 93/176 (52%), Gaps = 9/176 (5%)
Query: 504 GVEPKILN-EDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYCTGDG 562
GVE K+++ E G E++ PGE V R P +M +V G++ TGD
Sbjct: 32 GVEVKLIDSETGQEVK-PGELGEVLVRG-PNVMLGYWNCPAETAQVLKE---GWFHTGDI 86
Query: 563 VRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALYC 622
R DE+GY ++ RI DM+NV G + +EVE +L P V+E AV P + GE +
Sbjct: 87 GRIDEEGYFYLVDRIKDMVNVGGLKVYPSEVENMLYQHPAVAEVAVYGVPEPLLGEQVIA 146
Query: 623 FVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRK 678
++ K G+ A + + RQ + F P+ ++ LPK R+GKI+++ILR+
Sbjct: 147 NIIPKSGI---AVTTEEIVAFCRQNMADFKVPNLVELVESLPKGRTGKILKKILRE 199
>UniRef50_Q98AG0 Cluster: Acetyl-CoA synthetase; n=48; Bacteria|Rep:
Acetyl-CoA synthetase - Rhizobium loti (Mesorhizobium
loti)
Length = 562
Score = 87.8 bits (208), Expect = 9e-16
Identities = 52/160 (32%), Positives = 78/160 (48%), Gaps = 1/160 (0%)
Query: 522 EGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPG-YYCTGDGVRRDEDGYLWITGRIDDM 580
EG + P P M + D + G + TGD RD DG L GR DD+
Sbjct: 389 EGAIAALAPDPVMFLGYWNNPDATREKFIHGPEGRWLVTGDRGVRDNDGRLRFVGRDDDV 448
Query: 581 LNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALYCFVVLKEGLQFDADLVKTL 640
+ +G+ + AE+E L P V A V KP E++G + +VVL+EG +L + +
Sbjct: 449 IGSAGYRIGPAEIEDCLLGHPSVRLAGAVGKPDEIRGSVVAAYVVLREGFSPSQNLAEDI 508
Query: 641 TLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKIA 680
V+ ++ A P ++ +P T +GKI+R LRKIA
Sbjct: 509 AAHVKSRLAAHEYPRVVRFIDEMPMTTTGKIIRGALRKIA 548
Score = 51.2 bits (117), Expect = 9e-05
Identities = 52/227 (22%), Positives = 89/227 (39%), Gaps = 15/227 (6%)
Query: 252 EETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMY-AAATF 310
E ++ + E+ +S+ P ++DP ++YTSG+TG PKG +H L +
Sbjct: 166 EGDEVSFQEMCSEQSDTFIPVDTHSDDPAILIYTSGTTGNPKGALHAHRVLLGHLPGVEI 225
Query: 311 RYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKY 370
+ F D +W AD WI G V+ L + V + + + ++I
Sbjct: 226 SHDFLPKPDDRFWTPADWAWIGGLLDVLMPALHHGIPVVACRFSKF--TTEAAITLIRSQ 283
Query: 371 KVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKER 430
++ + PTA++ L E L LR + S GE + W +G
Sbjct: 284 RIRNVFLPPTALKMLKLKPAEECSGL------DLRSVASGGETLGAELIQWGKDALG--- 334
Query: 431 CSIVDTFWQTETGGHVITGLPGATPMKPGAAEKKHPVYYSSMDTFRP 477
+I + + QTE +++ P P PV +D P
Sbjct: 335 VTINEFYGQTEC-NMIVSSCAALEP--PALGSMGRPVPGHDVDVIDP 378
>UniRef50_Q89Y48 Cluster: Blr0107 protein; n=7;
Alphaproteobacteria|Rep: Blr0107 protein -
Bradyrhizobium japonicum
Length = 537
Score = 87.8 bits (208), Expect = 9e-16
Identities = 103/399 (25%), Positives = 163/399 (40%), Gaps = 54/399 (13%)
Query: 281 FVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYA 340
F +Y+SGSTG+PKG+VH A + V D+ + + + G V
Sbjct: 193 FWMYSSGSTGRPKGIVHLQHDMTYSEVAFAQNVLKLTPDDICFSVPKIFFAYGFGNSVTF 252
Query: 341 PLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPD 400
P + A +++ G P K ++ I +Y+ T F+ PT +L + N
Sbjct: 253 PFSVGAATLLLPGQP---KPATIFAAIEQYRPTVFFGLPTLYTSLTKAEGAQQTNF---- 305
Query: 401 LSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTETGGHVITGLPGATPMKPGA 460
SSLR+ S E ++ + W+T TG ++ GL G+
Sbjct: 306 -SSLRMALSAAEVLSAEVF----------------NGWKTLTGLEIVEGL--------GS 340
Query: 461 AEKKHPVYYSSMDTFRPKQGWDRTVMIVHLPNKSNRTRGFPFFGVEPKILNEDGVEIEGP 520
E H +Y S+ RP++ K G G E + N+DG E+ G
Sbjct: 341 TEVLH-IYLSN----RPER-------------KKLGAAGLRVPGYEVALRNKDGSEV-GD 381
Query: 521 GEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYCTGDGVRRDEDGYLWITGRIDDM 580
GE +++ R G T L + + G+ TGD RD DG+ + GR DD+
Sbjct: 382 GEEGILWVR---GDSNTPLYWNRPDKSAETIREGGWIYTGDRFVRDADGFHFFRGRADDL 438
Query: 581 LNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALYCFVVLKEGLQFDADLVKTL 640
+ +SG + EVE LA P + E AV + L VV+ + + L
Sbjct: 439 IKISGQWVYPLEVELCLADHPDIRECAVFAAELPDRRMTLKAVVVMNSRTTDQGEATRRL 498
Query: 641 TLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKI 679
V+ K+ + P + LPKT +GKI R+ L ++
Sbjct: 499 QDYVKGKLLPYKYPREVIFIDELPKTGTGKIDRQALLRM 537
Score = 41.9 bits (94), Expect = 0.057
Identities = 28/101 (27%), Positives = 47/101 (46%), Gaps = 6/101 (5%)
Query: 89 NVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMIL 148
N+ G+GDK+A TR TY +L C++ NG ++ G+++GDRV +++
Sbjct: 36 NLGKGYGDKLALIGPAG-----TR-TYAELCAEACRWGNGFISLGLKRGDRVLLFLDDTP 89
Query: 149 EAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLV 189
R G V ++ D L L+D+ A + V
Sbjct: 90 AYPAAFFGAVRAGFVPLLINTLTPPDLLQFYLADSGATVAV 130
>UniRef50_Q6MR22 Cluster: Long-chain fatty-acid-CoA ligase; n=1;
Bdellovibrio bacteriovorus|Rep: Long-chain
fatty-acid-CoA ligase - Bdellovibrio bacteriovorus
Length = 498
Score = 87.8 bits (208), Expect = 9e-16
Identities = 61/182 (33%), Positives = 89/182 (48%), Gaps = 9/182 (4%)
Query: 499 GFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYC 558
GFP F +E K+++ +G E+ G L+ P +M+ ++ + G+ C
Sbjct: 322 GFPNFYIEAKVVDPEGRELGSNQVGELLLRGPM--IMQGYWHNEKATQETIKE---GWLC 376
Query: 559 TGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGE 618
TGD VRRD++GY ++ GR DM G + EVE +L S P V EAAV+ P + GE
Sbjct: 377 TGDLVRRDDEGYYYVVGRKKDMFISGGENVYPPEVEQILRSHPGVLEAAVIGIPDDKWGE 436
Query: 619 ALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRK 678
FVV + +TL Q + F P P LPK SGKI++R+L +
Sbjct: 437 VGKAFVVRSS----NELTPETLHQHCIQNLAKFKIPKHFVFLPSLPKGDSGKILKRVLAE 492
Query: 679 IA 680
A
Sbjct: 493 TA 494
Score = 37.9 bits (84), Expect = 0.94
Identities = 37/136 (27%), Positives = 57/136 (41%), Gaps = 13/136 (9%)
Query: 263 EGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVY 322
+GE P E EDP +LYTSG+TG PKG + T + + + + + D
Sbjct: 141 QGEMPFVPKE----EDPAMILYTSGTTGSPKGAL-LTYKMIFWNSINTTLRLNISQTD-- 193
Query: 323 WCTADV--GWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPT 380
CT + TG V+ P + V+F F ++ S+ K K T + PT
Sbjct: 194 -CTVIFLPFFHTGGWNVLTTPFIHRGAKVVF--LKKF-DAEQILSLSEKEKATLLFGVPT 249
Query: 381 AIRALMAHYNVEDGNL 396
+ + + D NL
Sbjct: 250 TMEMMARSPRLNDINL 265
Score = 36.3 bits (80), Expect = 2.9
Identities = 27/83 (32%), Positives = 39/83 (46%), Gaps = 1/83 (1%)
Query: 108 DDYTRITYRKLLDLVCQFANGLLAK-GIRKGDRVAVYMPMILEAVICMLACARIGAVHTV 166
D +Y + DL A+ L K GI KGDRVAV LE V A R+GA+
Sbjct: 23 DTGREFSYAEFFDLANAGAHVLHEKFGICKGDRVAVLATNELEYVFLFFALQRLGAIMVP 82
Query: 167 VFAGFSSDALAERLSDAKAKLLV 189
V + + ++D+ KL++
Sbjct: 83 VNFRLTQREVNHIITDSSPKLVL 105
>UniRef50_Q4J553 Cluster: AMP-dependent synthetase and ligase; n=1;
Azotobacter vinelandii AvOP|Rep: AMP-dependent
synthetase and ligase - Azotobacter vinelandii AvOP
Length = 551
Score = 87.8 bits (208), Expect = 9e-16
Identities = 74/237 (31%), Positives = 118/237 (49%), Gaps = 23/237 (9%)
Query: 452 GATPMKPGAAEKKHPVYYSSMDTFRPKQGWDRTVMI--VHLPNKSNRTR----GFPFFGV 505
G T M AE+ + ++ ++GW T M+ VHL N R++ G P F V
Sbjct: 323 GGTSMPLAVAER-----FFALTGLEYQEGWGMTEMVAGVHL-NPYGRSKRQCLGVPMFEV 376
Query: 506 EPKILNED-GVEIEGPGE-GYLVFARPWPGMMRTLLEDQDRFERVYFSKFPG--YYCTGD 561
+ ++L+ D G E+ G GE G L+ P M + + + R F +F G ++ TGD
Sbjct: 377 DTRVLDPDTGGEL-GIGEKGELISRGP---CMFSGYWNNPQATREAFVEFDGQRFFRTGD 432
Query: 562 GVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALY 621
DE+GY ++ R+ M+NVSG+ + +EVE +L P + EA V+ +GE +
Sbjct: 433 IGYYDEEGYFFMADRLKRMVNVSGYKVWPSEVENILYRHPAIQEACVIACNRNDRGETVK 492
Query: 622 CFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRK 678
V L+ G A+ L R+ + A+ P ++ LPKT SGKI R+L++
Sbjct: 493 ALVALRPGATLAAE---ELMDWAREHMAAYKIPRAVEFVDELPKTGSGKIQWRLLQE 546
>UniRef50_A1SEZ8 Cluster: AMP-dependent synthetase and ligase; n=1;
Nocardioides sp. JS614|Rep: AMP-dependent synthetase and
ligase - Nocardioides sp. (strain BAA-499 / JS614)
Length = 541
Score = 87.8 bits (208), Expect = 9e-16
Identities = 46/124 (37%), Positives = 68/124 (54%)
Query: 555 GYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHE 614
G+ TGD D DG L+ GR DD++ G+ + AE+EG + + P V+E AVV P
Sbjct: 407 GWLLTGDSAHADADGNLYFHGRADDIIKSGGYRLGPAEIEGAILAHPDVAECAVVGLPDP 466
Query: 615 VKGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRR 674
+G+ + FVVL + +L L VR ++GA A P I+ GL K+ +GK+ R
Sbjct: 467 QRGQEVTAFVVLGADVVPSPELTTELQSRVRAEVGAHAYPRHIEYVDGLAKSSTGKVDRA 526
Query: 675 ILRK 678
LR+
Sbjct: 527 SLRR 530
Score = 62.1 bits (144), Expect = 5e-08
Identities = 38/94 (40%), Positives = 52/94 (55%), Gaps = 2/94 (2%)
Query: 106 SPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHT 165
+PD T +++ +L DL + A L G+ GDRVAV +P E I +LA ++GAV
Sbjct: 50 APDRTTEVSFGRLDDLSSRLAGVLRGLGVGVGDRVAVKLPQSAEMAIAVLATLKLGAVVV 109
Query: 166 VVFAGFSSDALAERLSDAKAKLLVTADGAWRGER 199
V DA+A RL D+ A +LV A G GER
Sbjct: 110 TVSNVLGVDAVAHRLEDSGALVLVCAGGI--GER 141
Score = 58.0 bits (134), Expect = 8e-07
Identities = 57/188 (30%), Positives = 81/188 (43%), Gaps = 15/188 (7%)
Query: 257 WWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDY 316
W L+G + A+DP +LYTSG+TG KGV+H L + A +D+
Sbjct: 159 WLGGALDGHEPLTSFASSGADDPALLLYTSGTTGSSKGVLHGHRVLLGHHAIDL--AWDH 216
Query: 317 HRR-DVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQF 375
R DV + D W G + PLA T V + P F +R +I+ V+
Sbjct: 217 VREGDVAYSPVDWSWAGGLMLGLLVPLAYGITVVAYR-EPRF-DAERTVAIMRDTGVSVG 274
Query: 376 YTAPTAIRALMAHYNVEDGNLTMPDLSS--LRVLGSVGEPINPAAWLWYYTRIGKERCSI 433
PTA+R L G LT +++ LRVL S E + W +G S+
Sbjct: 275 LFPPTALRVLQ-----RSGALTKETMATLRLRVLISGAEAVESELASWARDELG---LSV 326
Query: 434 VDTFWQTE 441
+ F QTE
Sbjct: 327 NNAFGQTE 334
>UniRef50_Q2PC83 Cluster: Putative polyketide synthase; n=2;
Actinomycetales|Rep: Putative polyketide synthase -
Streptomyces achromogenes subsp. rubradiris
Length = 5349
Score = 87.4 bits (207), Expect = 1e-15
Identities = 58/182 (31%), Positives = 94/182 (51%), Gaps = 16/182 (8%)
Query: 499 GFPFFGVEPKILN-EDGVEIEGPGEGYLVFARP--WPGMMRTLLEDQDRFERVYFSKFPG 555
G P GV+ +I++ E G ++ EG + P PG ++ E + G
Sbjct: 340 GLPVPGVDVRIVDPETGRDVPAGAEGEVWVRGPNVTPGY-------HNKPEATAAAFQDG 392
Query: 556 YYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEV 615
+Y TGD RRD GY I+GRI+D++ G + E+E V+ + P +++ V +PHEV
Sbjct: 393 WYRTGDLARRDAAGYFTISGRINDLIVRGGENVHPEEIEAVIRAVPGIADVGVAGRPHEV 452
Query: 616 KGEALYCFVVL-KEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRR 674
GE +VV G++ DA + + R+++ F P+ + G+P+T SGKI RR
Sbjct: 453 LGEVPVAYVVAGPSGVEADAVIER-----CRRELSTFKLPEEVYEVAGVPRTASGKIQRR 507
Query: 675 IL 676
+L
Sbjct: 508 LL 509
Score = 40.3 bits (90), Expect = 0.18
Identities = 33/114 (28%), Positives = 52/114 (45%), Gaps = 6/114 (5%)
Query: 77 AELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRK 136
AEL L+ R + FG K+AF D +TY L + A L G+R+
Sbjct: 7 AELIRALPLVLREHADNFGGKVAF------EDAERAVTYADLEARTRRLAGHLAGLGVRR 60
Query: 137 GDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVT 190
GDRV + + +E + LA R A+ V + L L+D++A +++T
Sbjct: 61 GDRVMICLRNSVEMLESYLAILRADAIGVPVNPASTDFELDYLLADSEAAVVIT 114
Score = 38.3 bits (85), Expect = 0.71
Identities = 43/176 (24%), Positives = 67/176 (38%), Gaps = 12/176 (6%)
Query: 277 EDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTY 336
+D + YTSG+T +PKGV+ + L AA++ + D + H
Sbjct: 168 DDVAWTFYTSGTTREPKGVLSSQRNCLYSVAASYVPIPGLSADDRVLWPLPLFHSLSHIA 227
Query: 337 VVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNL 396
V A A AT+ + + P D + + + T PT L+ +
Sbjct: 228 CVLAVTAVGATARIMDS----PSGDEFLEAARETRATFVAGVPTTYHYLLEAR--RQRRI 281
Query: 397 TMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTETGGHVITGLPG 452
T+PDL V G+V P + G +VD + TET G + PG
Sbjct: 282 TLPDLRIGLVGGAVA---GPGLCRSFREEFG---VPLVDAYGSTETCGAITMNPPG 331
>UniRef50_Q04R11 Cluster: Acyl-CoA synthetase; n=2; Leptospira
borgpetersenii serovar Hardjo-bovis|Rep: Acyl-CoA
synthetase - Leptospira borgpetersenii serovar
Hardjo-bovis (strain JB197)
Length = 541
Score = 87.4 bits (207), Expect = 1e-15
Identities = 58/178 (32%), Positives = 92/178 (51%), Gaps = 13/178 (7%)
Query: 504 GVEPKILNEDGVEI--EGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYCTGD 561
GVE K +++ G +I +G G L+ PW ++ F G++ TGD
Sbjct: 365 GVELKGIDDQGKDIPKDGKTPGELIVRGPWITASYYGNPSKESFTE------DGWFRTGD 418
Query: 562 GVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALY 621
+ DE GY+ IT R D++ G +S+ E+E + P V EAAVV KP+E++GE
Sbjct: 419 VITIDEHGYIQITDRKKDLIKTRGEWISSVEMESYVLKAPGVLEAAVVAKPNEIRGEVPV 478
Query: 622 CFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAP--DTIQNAPGLPKTRSGKIMRRILR 677
FVV KEG + D K++ ++++ + P D I+ +PKT GK +++LR
Sbjct: 479 VFVVAKEGEKVDK---KSVLDILKENFANWQLPHSDDIRLIEAIPKTSVGKFDKKVLR 533
>UniRef50_Q89T13 Cluster: Bll2237 protein; n=2; Bradyrhizobium|Rep:
Bll2237 protein - Bradyrhizobium japonicum
Length = 2154
Score = 87.0 bits (206), Expect = 2e-15
Identities = 58/173 (33%), Positives = 83/173 (47%), Gaps = 8/173 (4%)
Query: 504 GVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYCTGDGV 563
G E +++E G + G +V M R D+ + + G++ TGD
Sbjct: 354 GPEIAVMDETGRALASGAHGEIVLRGA--NMSRGYYNDEAATQAAFRD---GWFRTGDLG 408
Query: 564 RRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALYCF 623
D DGYL+I GRI D++N G +S EVE VL S P V EA V PH GE +
Sbjct: 409 YLDADGYLFIVGRIKDVINRGGQKISPLEVEEVLLSHPAVLEAGVFAVPHPKLGENVAAV 468
Query: 624 VVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRIL 676
VVL+ + +D L R+++ A+ P I++ LPK SGK+ R L
Sbjct: 469 VVLRANSEATSD---QLRKFARKRLAAYKVPSLIRSVAALPKGASGKVKRNAL 518
Score = 50.4 bits (115), Expect = 2e-04
Identities = 35/121 (28%), Positives = 53/121 (43%), Gaps = 5/121 (4%)
Query: 557 YCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVK 616
Y TGD RR DG + GR D + V G+ + E+E LA P V V P+ E
Sbjct: 1475 YRTGDLARRRADGTIECLGRADHQVKVRGYRIELKEIENALADHPSVRAGIVEPR-REAS 1533
Query: 617 GEA-LYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRI 675
G+ L +V + G + A ++ ++ ++ A P +P GKI R +
Sbjct: 1534 GDVRLIAHIVARPGSRVSASELRD---FLKSRLPGHAIPSAFLFMDQVPLNAHGKIDRSM 1590
Query: 676 L 676
L
Sbjct: 1591 L 1591
Score = 35.9 bits (79), Expect = 3.8
Identities = 35/140 (25%), Positives = 58/140 (41%), Gaps = 6/140 (4%)
Query: 275 AAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGH 334
AA +++YTSGS+G PKGV+ G + A+ + RDV TA ++
Sbjct: 1231 AASSLAYLIYTSGSSGAPKGVMIEQRGLSNHLASLISEL-KLSARDVIAQTAPQSFVISV 1289
Query: 335 TYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDG 394
+ P+ A V P + I + +T P+ +R ++ D
Sbjct: 1290 WQFLAGPMVGARVHVCGNAIVQDPIL--LAREIEREGITVLEIVPSLLRVIVDRM---DE 1344
Query: 395 NLTMPDLSSLRVLGSVGEPI 414
+ + LR+L S GEP+
Sbjct: 1345 APILRAFARLRLLISTGEPL 1364
>UniRef50_Q0AL69 Cluster: AMP-dependent synthetase and ligase; n=4;
Proteobacteria|Rep: AMP-dependent synthetase and ligase
- Maricaulis maris (strain MCS10)
Length = 546
Score = 87.0 bits (206), Expect = 2e-15
Identities = 62/174 (35%), Positives = 87/174 (50%), Gaps = 7/174 (4%)
Query: 504 GVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYCTGDGV 563
G + +++ +DG E+ G L P G + L+D DR + Y G+ TGD
Sbjct: 380 GYQARLIGDDGDEVPVGEVGRLAVRGP-TGCL--YLKD-DR-QAGYVQD--GWNLTGDLF 432
Query: 564 RRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALYCF 623
RRDEDGY W R DD++ SG+ ++ EVE L + P V+E AVV P +G + F
Sbjct: 433 RRDEDGYFWYFSRADDLIVSSGYNIAGPEVEQALLTHPAVAECAVVGAPDAERGTIVKAF 492
Query: 624 VVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILR 677
VVLK G L L V+ I + P + LPKT++GK+ R LR
Sbjct: 493 VVLKAGHCAGETLACALQDHVKATIAPYKYPRAVAFLDSLPKTQTGKLQRFKLR 546
Score = 56.0 bits (129), Expect = 3e-06
Identities = 51/169 (30%), Positives = 73/169 (43%), Gaps = 14/169 (8%)
Query: 250 WNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAAT 309
W E++++ L G+ A +D + +TSG+TG+PK H + L A
Sbjct: 181 WGEDSEL--AAALPGKPADFDNADTARDDVALLAFTSGTTGQPKACAHFHSSVLAMADTF 238
Query: 310 FRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINK 369
R+ ++Y T + G V P A A +V P F D I
Sbjct: 239 GRHGLVPDSDEIYTGTPPFAFTFGLGAFVVFP-ARAGIAVALPDKPGF---DALCECIET 294
Query: 370 YKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAA 418
+K T +TAP RALMA+++ DLSSLR S GE + PAA
Sbjct: 295 FKATTLFTAPMGYRALMANWDTH-------DLSSLRKCVSAGEHL-PAA 335
Score = 40.7 bits (91), Expect = 0.13
Identities = 31/101 (30%), Positives = 50/101 (49%), Gaps = 7/101 (6%)
Query: 79 LNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAK-GIRKG 137
LN LLDR V G GD++A + + S +TY LL + A+ L+ + GI G
Sbjct: 51 LNCGTELLDRTVDKGLGDRMAVYSKARS------LTYAGLLAEANRLAHYLVDEMGIIPG 104
Query: 138 DRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAE 178
+RV ++ P ++ ++ A + GAV F + LA+
Sbjct: 105 NRVLLHGPNGVDLMVAWYAVMKTGAVAVTTMPMFRAGELAK 145
>UniRef50_Q6DJK1 Cluster: MGC82117 protein; n=15; root|Rep: MGC82117
protein - Xenopus laevis (African clawed frog)
Length = 584
Score = 86.6 bits (205), Expect = 2e-15
Identities = 51/134 (38%), Positives = 68/134 (50%), Gaps = 2/134 (1%)
Query: 546 ERVYFSKFPGYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSE 605
ER ++ +Y TGD +DEDGY W GR DD++ SG+ + E+E L P V+E
Sbjct: 441 ERTASTRRGNFYLTGDRGIKDEDGYFWFVGRSDDVILSSGYRIGPFEIESALIEHPAVAE 500
Query: 606 AAVVPKPHEVKGEALYCFVVLKEGLQFDADLVKTLTLL--VRQKIGAFAAPDTIQNAPGL 663
+AVV P ++GE + FVVL TL L V+ + P I+ L
Sbjct: 501 SAVVSSPDPIRGEVVKAFVVLAPAYNGHDPEKLTLELQEHVKNITAPYKYPRKIEFVQQL 560
Query: 664 PKTRSGKIMRRILR 677
PKT SGKI R LR
Sbjct: 561 PKTVSGKIRRNELR 574
Score = 75.8 bits (178), Expect = 4e-12
Identities = 57/194 (29%), Positives = 84/194 (43%), Gaps = 15/194 (7%)
Query: 276 AEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHT 335
+ DP+ + +TSG+TG PK H+ Y +Y D D+ W +D GW
Sbjct: 221 SSDPMTIFFTSGTTGSPKMTEHSHCSYGHGLKVNGKYWMDLTPSDIVWNMSDTGWAKSAW 280
Query: 336 YVVYAPLANAATSVMFEGTPYF-PKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDG 394
V+AP + V P F P + ++ + +T F +APTA R +
Sbjct: 281 SSVFAPWIQ-GSCVFAHSMPRFDPNI--VLQTLSTFPITTFCSAPTAYRIFVLQ------ 331
Query: 395 NLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTETGGHVITGLPGAT 454
NL SL+ S GEPINP + + G + I + + QTET +I G
Sbjct: 332 NLASYQFKSLQHCVSAGEPINPQVMEQWKEQTGLD---IYEGYGQTET--VLICGTFKGM 386
Query: 455 PMKPGAAEKKHPVY 468
+KPG+ K P Y
Sbjct: 387 KIKPGSMGKPSPAY 400
Score = 38.3 bits (85), Expect = 0.71
Identities = 31/117 (26%), Positives = 54/117 (46%), Gaps = 4/117 (3%)
Query: 80 NVCYNLLD---RNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLL-AKGIR 135
N ++LD RN K G W + + + ++ +L L + AN + A ++
Sbjct: 54 NFANDILDEWARNRKEGGKSSNPALWWIDGSGEEIKWSFEELGFLSRKAANIISDACNLK 113
Query: 136 KGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTAD 192
GDRV V +P + E + +AC R G V ++ + RL + AK ++T+D
Sbjct: 114 PGDRVIVILPRVPEWWLLNVACIRAGVVLIPGTTQLTAKDILHRLQTSMAKCIITSD 170
>UniRef50_Q67RT9 Cluster: Long-chain fatty-acid-CoA ligase; n=5;
Bacteria|Rep: Long-chain fatty-acid-CoA ligase -
Symbiobacterium thermophilum
Length = 568
Score = 86.6 bits (205), Expect = 2e-15
Identities = 56/179 (31%), Positives = 91/179 (50%), Gaps = 9/179 (5%)
Query: 499 GFPFFGVEPKILN-EDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYY 557
G P+ G + +I++ E G ++ GEG ++ P +M+ + V G+
Sbjct: 380 GLPYPGTDVRIVDLETGEDLPPGGEGEILIRGPQ--VMKGYWNRPEETAEVLKD---GWL 434
Query: 558 CTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKG 617
TGD R D++GYL+I R DM+ G + E++ VL P V EA V P +G
Sbjct: 435 YTGDIGRMDDEGYLYIVDRKKDMIIAGGFNIYPREIDEVLYQHPAVLEACAVGVPDAYRG 494
Query: 618 EALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRIL 676
E + FVVLK G Q + + R+++ A+ P +++ P LPK+ GK++RR+L
Sbjct: 495 ETVKAFVVLKPGAQATE---QEILEFCRERLAAYKRPRSVEFLPELPKSTVGKVLRRVL 550
Score = 57.6 bits (133), Expect = 1e-06
Identities = 29/89 (32%), Positives = 53/89 (59%), Gaps = 1/89 (1%)
Query: 112 RITYRKLLDLVCQFANGLLAK-GIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAG 170
R++Y +L+DL+ +F L + GI+KGDRV + +P + VI +AC RIGA+
Sbjct: 58 RVSYGELVDLIDRFGAALQRRYGIQKGDRVGIILPNSPQNVIATVACQRIGAIPVQFNPL 117
Query: 171 FSSDALAERLSDAKAKLLVTADGAWRGER 199
+ + +A ++ D+ ++++T D W+ R
Sbjct: 118 YVAREIAYQVKDSGCRIMITLDLFWQKVR 146
>UniRef50_A4FDM8 Cluster: Modular polyketide synthase-; n=1;
Saccharopolyspora erythraea NRRL 2338|Rep: Modular
polyketide synthase- - Saccharopolyspora erythraea
(strain NRRL 23338)
Length = 4132
Score = 86.6 bits (205), Expect = 2e-15
Identities = 52/123 (42%), Positives = 71/123 (57%), Gaps = 6/123 (4%)
Query: 555 GYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHE 614
G+Y TGD RRDE GY I+GRI +++ G + +VE VL S P V++AAVV KPHE
Sbjct: 387 GWYRTGDLARRDESGYFTISGRIKELIIRGGENIHPGDVEAVLRSVPGVADAAVVGKPHE 446
Query: 615 VKGEALYCFVVL-KEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMR 673
V GE F+V EGL D + V + RQ++ P+ + +P+T SGKI R
Sbjct: 447 VLGEVPVAFLVPGPEGL--DPEHV---LAVCRQELSYIKVPEELYEIDRVPRTASGKITR 501
Query: 674 RIL 676
+L
Sbjct: 502 HVL 504
Score = 37.5 bits (83), Expect = 1.2
Identities = 33/132 (25%), Positives = 54/132 (40%), Gaps = 6/132 (4%)
Query: 279 PLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTYVV 338
P ++LYTSG+TG+PKGV+ + L AA + + D + H V
Sbjct: 165 PAWMLYTSGTTGRPKGVLSSQRNCLWSVAACYVPIPGLSEEDRVLWPLPLFHSLSHIACV 224
Query: 339 YAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTM 398
A AT+ + +G D + + + T PT L+ + L++
Sbjct: 225 LGVTAVGATARVLDGF----SADEVLNALREDSTTFLAGVPTMYHHLVR--AAGEQRLSL 278
Query: 399 PDLSSLRVLGSV 410
PDL V G++
Sbjct: 279 PDLRMCLVGGAI 290
>UniRef50_O29418 Cluster: Long-chain-fatty-acid--CoA ligase; n=4;
cellular organisms|Rep: Long-chain-fatty-acid--CoA
ligase - Archaeoglobus fulgidus
Length = 577
Score = 86.6 bits (205), Expect = 2e-15
Identities = 60/181 (33%), Positives = 91/181 (50%), Gaps = 8/181 (4%)
Query: 499 GFPFFGVEPKILNEDGVEIEGPGE-GYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYY 557
G P+ +++E+G I PGE G L P +M+ + E+ + G+
Sbjct: 394 GVPYPDTYAVVIDEEG-NILPPGEEGELAIYGPQ--VMKGYWMMDEETEKTLIN---GWL 447
Query: 558 CTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKG 617
TGD + DEDGY +I R DM+ G+ + EVE VL P V+EAAVV P +G
Sbjct: 448 LTGDMAKMDEDGYFYIVDRKKDMIVAGGYNIYPREVEEVLFEHPAVAEAAVVGVPDPYRG 507
Query: 618 EALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILR 677
E + FVVL+ + K L R+++ A+ P + LPK+ GK++RR+LR
Sbjct: 508 ETVKAFVVLRPEYKGKV-TEKDLDKFCRERLAAYKVPRLYEFRDELPKSLVGKVLRRVLR 566
Query: 678 K 678
+
Sbjct: 567 E 567
Score = 59.7 bits (138), Expect = 3e-07
Identities = 90/364 (24%), Positives = 154/364 (42%), Gaps = 40/364 (10%)
Query: 63 DITK-GRVFVKFMEEA-ELNVCYNLLD--RNVKNGFG---DKIAFFWEGNSPDDYTRITY 115
D+TK RV+ KF +E N+ Y ++ R +++ DKI F + G T+ TY
Sbjct: 15 DVTKINRVWTKFYDEGVRANIDYPVMPAYRILEDAAASDPDKICFEFFG------TKWTY 68
Query: 116 RKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDA 175
R++ D + AN L G+ KGDR+ V +P + I A ++G + ++
Sbjct: 69 RQMKDASDKVANFLFDIGVEKGDRIVVALPNLPHYAIIANAIYKVGGIVVQCNPIYTERE 128
Query: 176 LAERLSDAKAKLLVTADGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVT 235
+ + ++ A + +G + R + D +EK V +C + + L V
Sbjct: 129 IRYIVKNSGATRMFAFEGMYPRIRPLIE----DGTLEK--------VVICRIEDFLGFVM 176
Query: 236 PG---GSLKSEIKDLYNWNEETD-IWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGK 291
LK ++ + + + ++W +VL+ E E ED YT G+TG
Sbjct: 177 SALFKAFLKKKMVGKVDIDRRKEVVFWQDVLKYERTDKRAEINPKEDVAMFQYTGGTTGF 236
Query: 292 PKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWI-TGHTYVVYAPLANAATSVM 350
PK V+ T ++ A V ++ R A VG + H Y + ++A +
Sbjct: 237 PKAVMLTHYNLVVNA----YQVAEWDPRTTPSDVA-VGCLPVFHVYGMTMLNSSAVLRMK 291
Query: 351 FEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSV 410
P V+ ++KYK T F PT +++ H L+ DL+SLRV S
Sbjct: 292 VIPIPDPRDVEAILKAVHKYKATTFTGVPTMFISMLNH-----PKLSKYDLTSLRVCVSG 346
Query: 411 GEPI 414
P+
Sbjct: 347 AAPL 350
>UniRef50_A3Q3Y3 Cluster: AMP-dependent synthetase and ligase; n=3;
Mycobacterium|Rep: AMP-dependent synthetase and ligase -
Mycobacterium sp. (strain JLS)
Length = 527
Score = 86.2 bits (204), Expect = 3e-15
Identities = 66/186 (35%), Positives = 93/186 (50%), Gaps = 17/186 (9%)
Query: 497 TRGFPFFGVEPKILNEDGVEIEGPGEGYLVFARP--WPGMMRTLLEDQDRFERVYFSKFP 554
T G P G +ILN DGVE+ +G +V P + G LL D+ F+
Sbjct: 343 TDGKPMPGSVVRILNPDGVELPADADGEVVVRGPEQFIGYRDPLLNDE------VFTD-D 395
Query: 555 GYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHE 614
G++ TGD R D +G L IT R+ D++ G +S+A+VE VLA+ P VSE AVV P
Sbjct: 396 GWFRTGDLGRVDAEGRLTITDRLKDVIIRGGETISSAQVEDVLATHPAVSEGAVVAAPDA 455
Query: 615 VKGEALYCFVVLKEGLQFDADLVK---TLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKI 671
GE + VV+K G D +K L +QK+ P+ + LP+T GK+
Sbjct: 456 RVGEVVAAVVVVKPGAHLDLTALKHHFAAAGLAKQKV-----PERLVIVDALPRTSLGKV 510
Query: 672 MRRILR 677
+ LR
Sbjct: 511 RKAELR 516
Score = 37.9 bits (84), Expect = 0.94
Identities = 33/129 (25%), Positives = 59/129 (45%), Gaps = 8/129 (6%)
Query: 258 WHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYH 317
W E++ + + P V A+D ++YTSG+T PKGV H T ++ A+ +
Sbjct: 159 WSELVPCDEYVRPE--VDADDVCLLMYTSGTTSAPKGVQH-THNTVLAEQASMPALIAGE 215
Query: 318 RRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYT 377
+DV + G I G ++ A ++ A T + R II ++VT
Sbjct: 216 PQDVSLVSFPPGHIAGVGSMLRALMSGARTVFLQRW-----DARRAVEIIRDFEVTSTAG 270
Query: 378 APTAIRALM 386
PT +++++
Sbjct: 271 VPTHLQSIL 279
Score = 36.3 bits (80), Expect = 2.9
Identities = 25/85 (29%), Positives = 38/85 (44%)
Query: 108 DDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVV 167
D R + +L D A L G+R GD VAV + E I A GAV +
Sbjct: 45 DSVHRTSVAELHDAAVGLAAALQRLGVRAGDAVAVQLTNRPECAIAYQAVLLSGAVLVPI 104
Query: 168 FAGFSSDALAERLSDAKAKLLVTAD 192
+ + + +S ++A +L+TAD
Sbjct: 105 VHIYGAGEVGFIVSQSRASVLITAD 129
>UniRef50_Q3IUK7 Cluster: Acyl-CoA synthetase I 5; n=2;
Halobacteriaceae|Rep: Acyl-CoA synthetase I 5 -
Natronomonas pharaonis (strain DSM 2160 / ATCC 35678)
Length = 544
Score = 86.2 bits (204), Expect = 3e-15
Identities = 45/124 (36%), Positives = 64/124 (51%)
Query: 555 GYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHE 614
G++ TGD RDEDGY+W R DD++ SG+ + EVE + P + +A VV P E
Sbjct: 419 GWHLTGDLAERDEDGYIWFKSRDDDIIITSGYRVGPGEVEEAILEHPDIEQAGVVGVPDE 478
Query: 615 VKGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRR 674
+GE + F EG+ D L + LV++ + P + LP T +GKI R
Sbjct: 479 TRGEIIKAFCQPVEGVAGDDGLRTEVQSLVKENLAKHEYPRELTFVDELPTTTTGKIRRT 538
Query: 675 ILRK 678
LRK
Sbjct: 539 ELRK 542
Score = 78.2 bits (184), Expect = 7e-13
Identities = 90/365 (24%), Positives = 156/365 (42%), Gaps = 47/365 (12%)
Query: 78 ELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKG 137
+ N Y+L+ K+ D+ A F + ++ L D + AN L G+ +G
Sbjct: 26 DYNAAYDLVG---KHEHADRPALF-QAYPDGRREEYSFGDLDDESDRLANALADLGVGRG 81
Query: 138 DRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRG 197
DRV V +P + I LAC ++GAV + F D L RL D++A +
Sbjct: 82 DRVGVVLPQVPANPITHLACWKLGAVSMPLSVLFGPDGLQYRLDDSEATVA--------- 132
Query: 198 ERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIW 257
V R + ++ R + C + H+ V G+ +E + +
Sbjct: 133 ----VVDRDSYETVDGIR-------ERCAGLEHVVEVDWAGA---------GHHEGSTTF 172
Query: 258 WHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYH 317
V +S+ P + + E P ++YTSGSTG PKG +HT + ++ + A F+ F+
Sbjct: 173 SGLVAAADSSFEPVD-TSPETPAIIMYTSGSTGPPKGALHTHSVWVGHCPA-FKMYFELD 230
Query: 318 RRD-VYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFY 376
+ V+W AD WI +V+ V + + P++ + + ++ VT +
Sbjct: 231 MSEAVFWTPADWAWIGALGDLVFPAWHYGRPVVGYPMGEFDPEL--AFELSAEFDVTSTF 288
Query: 377 TAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDT 436
PTAIR LM +E + + SL + S GEP+ W + + ++ +
Sbjct: 289 LPPTAIRMLM---GIETDSYDL----SLEAICSGGEPLTSEILEWAEAEL--DGVAVNEL 339
Query: 437 FWQTE 441
+ QTE
Sbjct: 340 YGQTE 344
>UniRef50_UPI000038E2BB Cluster: hypothetical protein Faci_03001660;
n=1; Ferroplasma acidarmanus fer1|Rep: hypothetical
protein Faci_03001660 - Ferroplasma acidarmanus fer1
Length = 559
Score = 85.8 bits (203), Expect = 4e-15
Identities = 43/125 (34%), Positives = 69/125 (55%)
Query: 555 GYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHE 614
GYY TGD D++GY + R DD++ S + + EVE + + V E+AV+ P
Sbjct: 418 GYYLTGDKAYFDDNGYFYFISRTDDVIKTSDYRVGPFEVESAIIKNEAVLESAVIGIPDS 477
Query: 615 VKGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRR 674
+K E + FV+LK+G + K++ V+ + A+ P I+ LPKT SGKI R+
Sbjct: 478 MKYEKIKAFVILKDGYVKSEETAKSIHSTVKTLLPAYKCPRVIEFTDELPKTISGKIKRK 537
Query: 675 ILRKI 679
L+++
Sbjct: 538 ELKQL 542
Score = 61.3 bits (142), Expect = 9e-08
Identities = 64/227 (28%), Positives = 101/227 (44%), Gaps = 20/227 (8%)
Query: 240 LKSEIKDLYNWNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLY-TSGSTGKPKGVVHT 298
L +E L N E I + E+ + E N P E +D LF+ Y TSG+TG PK V H+
Sbjct: 155 LNTEALKLVIGNREGWISFDEIYKMEINAEPAE--LGKDDLFIKYFTSGTTGMPKAVRHS 212
Query: 299 TAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAAT--SVMFEGTPY 356
+ Y + +T + ++ + GW +APL AT S+ + G
Sbjct: 213 SILYPIGQLSTVTAI-GIRPEYIHNNLSSPGWAKFAWSSFFAPLCAGATVLSIDYRGR-- 269
Query: 357 FPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINP 416
RY +I++YKV F PTA R ++ N+ N+ +L L+ S GEP+N
Sbjct: 270 -LNSSRYLELIDRYKVNTFCAPPTAWRQFISLKNL---NI---ELKHLKETVSAGEPLNG 322
Query: 417 AAWLWYYTRIGKERCSIVDTFWQTETGGHVITGLPGATPMKPGAAEK 463
+ R G +++ F+ ++ L G P+ PG+ K
Sbjct: 323 EVINKWKERYG----TVIRDFYGQSESTAMVANLAGEEPV-PGSMGK 364
Score = 48.4 bits (110), Expect = 7e-04
Identities = 35/141 (24%), Positives = 63/141 (44%), Gaps = 3/141 (2%)
Query: 57 FMKYNFDITKGR-VFVKFMEEAELNVCYNLLDRNVKNGFG--DKIAFFWEGNSPDDYTRI 113
+ K+ F +KGR + ++ ++N +N + + F DK A + + RI
Sbjct: 7 YKKFIFSNSKGRNTMLGELKSLKINEPFNWVSEIFEKLFAGNDKDAIIYINEGTGEERRI 66
Query: 114 TYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSS 173
+YRKL + QF N L A+GI KG V + I E + M+ + G + A +
Sbjct: 67 SYRKLYESYNQFINFLRAEGINKGSSVYIMAGSIPEQWVVMMGALKAGFIVIPTAANLTE 126
Query: 174 DALAERLSDAKAKLLVTADGA 194
L R S ++++ + +
Sbjct: 127 YELNYRFSQDSPDVIISDEAS 147
>UniRef50_Q5KZW0 Cluster: Long-chain fatty-acid-CoA ligase; n=6;
Bacillaceae|Rep: Long-chain fatty-acid-CoA ligase -
Geobacillus kaustophilus
Length = 511
Score = 85.8 bits (203), Expect = 4e-15
Identities = 53/172 (30%), Positives = 89/172 (51%), Gaps = 8/172 (4%)
Query: 506 EPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYCTGDGVRR 565
E +++E+G E+ PGE + R +M+ +D+++ V G+ TGD RR
Sbjct: 336 EVALVDENGQEV-APGEVGEIVLRG-ESIMKGYYKDEEKTNEVIKD---GWLYTGDLARR 390
Query: 566 DEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALYCFVV 625
DEDGY+WI R D++ G + EVE VL + P +++ AV+ PH GE FVV
Sbjct: 391 DEDGYIWIVDRKKDVIISGGVNIYPKEVEDVLRTHPAIADVAVIGVPHPEWGETAKAFVV 450
Query: 626 LKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILR 677
L + L+ L + + K+ + P + LP+ +GK+++++LR
Sbjct: 451 LSQPLE---PLAEECKRFLSDKLADYKIPRLYEAIAELPRNATGKVLKQVLR 499
Score = 47.2 bits (107), Expect = 0.002
Identities = 34/108 (31%), Positives = 56/108 (51%), Gaps = 7/108 (6%)
Query: 85 LLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAVYM 144
LL RN + F +K A EG S ++Y ++ +V + A+ L G+ +GD+VA+YM
Sbjct: 6 LLARNARK-FPEKTAVI-EGESS-----LSYAEVNCMVNRLASSLARLGVGRGDKVALYM 58
Query: 145 PMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTAD 192
P E + A R+GAV + A ++ + L ++AK L+ D
Sbjct: 59 PNTKEFAVSYFAVLRLGAVVVPINARLTAAEVQYILGHSEAKALIAHD 106
Score = 41.5 bits (93), Expect = 0.076
Identities = 43/167 (25%), Positives = 69/167 (41%), Gaps = 15/167 (8%)
Query: 265 ESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYA-AATFRYVFDYHRRDVYW 323
E +CP + +D +LYTSG+TG+PKGV+ T + A D R ++
Sbjct: 146 EEIVCPAK---EDDEATILYTSGTTGRPKGVLFTHRNVITVADMIVIETKIDRQSRLLHL 202
Query: 324 CTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIR 383
H + + AT V+ P F D ++ ++K+T F+ AP A
Sbjct: 203 MPLSHS-APLHLFFIGGTYV-GATHVL---APAF-SPDALLELVERHKITHFFGAPVAYL 256
Query: 384 ALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKER 430
H ++ DLSS+R G P++ + +R G R
Sbjct: 257 LTAKHPRFDE-----YDLSSVRCWMYGGAPLSREEVKFVASRFGAGR 298
>UniRef50_Q1AV80 Cluster: AMP-dependent synthetase and ligase; n=3;
Bacteria|Rep: AMP-dependent synthetase and ligase -
Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Length = 549
Score = 85.8 bits (203), Expect = 4e-15
Identities = 61/181 (33%), Positives = 94/181 (51%), Gaps = 8/181 (4%)
Query: 499 GFPFFGVEPKILNEDGVEIEGP-GE-GYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGY 556
G P G + ++++ + E E P GE G LV P + + + E + G+
Sbjct: 359 GVPIPGTDVRVVDPETGEREMPVGEPGELVVKGP-----QVMKGYWNMPEETSLALRDGW 413
Query: 557 YCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVK 616
TGD VR DE+GYL+I R DM+NVSG+ + EVE V+ S P V EA VV P +
Sbjct: 414 LYTGDIVRMDEEGYLYIVDRKKDMINVSGYKVYPREVEEVIYSHPEVVEAVVVGSPDPYR 473
Query: 617 GEALYCFVVL-KEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRI 675
GE FVV+ + G + + + L R+++ + P ++ LPK+ GK++RR+
Sbjct: 474 GEVPKAFVVIRRRGGEGTSVSEEELIEHCRRELAPYKVPREVEFREELPKSAVGKLLRRV 533
Query: 676 L 676
L
Sbjct: 534 L 534
Score = 44.0 bits (99), Expect = 0.014
Identities = 27/77 (35%), Positives = 39/77 (50%)
Query: 113 ITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFS 172
I+YR+LL+L FA L G+ KGDRV + +P E VI R GA T + ++
Sbjct: 50 ISYRELLELSEGFAAALAGSGVCKGDRVGLMLPNCPEYVIGFFGTVRAGAAATQINPLYT 109
Query: 173 SDALAERLSDAKAKLLV 189
L LS++ + V
Sbjct: 110 GRELEHILSNSGTQTAV 126
>UniRef50_A3I408 Cluster: Long-chain fatty-acid-CoA ligase; n=2;
Bacillus|Rep: Long-chain fatty-acid-CoA ligase -
Bacillus sp. B14905
Length = 514
Score = 85.8 bits (203), Expect = 4e-15
Identities = 59/179 (32%), Positives = 88/179 (49%), Gaps = 8/179 (4%)
Query: 499 GFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYC 558
G P E ++++ +G E+ GE + R P +M+ L + + R G+
Sbjct: 338 GKPLGQTEVRVVDSEGKEVPA-GEVGEICVRG-PQVMKGYLRNPEETARTIID---GWLY 392
Query: 559 TGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGE 618
+GD R DE+GYL+I R DM+ G + EVE VL P + EAAVV PHEV GE
Sbjct: 393 SGDLGRFDEEGYLYIVDRKKDMIIRGGENIYPIEVEEVLYQLPEILEAAVVGLPHEVYGE 452
Query: 619 ALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILR 677
FVV KEG D + + + ++ + P I+ LP+ SGK+++ LR
Sbjct: 453 VPKAFVVFKEGKSLDEE---NILSYCQSQLAKYKVPYEIECLTELPRNASGKVLKHTLR 508
Score = 35.1 bits (77), Expect = 6.6
Identities = 15/23 (65%), Positives = 18/23 (78%)
Query: 276 AEDPLFVLYTSGSTGKPKGVVHT 298
A D V+YTSG+TGKPKGV+ T
Sbjct: 164 ANDTAVVMYTSGTTGKPKGVMLT 186
>UniRef50_O30147 Cluster: Long-chain-fatty-acid--CoA ligase; n=1;
Archaeoglobus fulgidus|Rep: Long-chain-fatty-acid--CoA
ligase - Archaeoglobus fulgidus
Length = 542
Score = 85.8 bits (203), Expect = 4e-15
Identities = 70/239 (29%), Positives = 119/239 (49%), Gaps = 16/239 (6%)
Query: 452 GATPMKPGAAEK--KHPVYYSSMDTFRPKQGWDRT----VMIVHLPNKSNR--TRGFPFF 503
GA P+ P EK K + R Q W T ++ + P + ++ T+G P
Sbjct: 302 GAWPVAPALVEKLLKLAAEKCNNPRLRHNQIWGMTEACPMVTTNPPLRLDKSTTQGVPMS 361
Query: 504 GVEPKILN-EDGVEIEGPGE-GYLVFARP--WPGMMRTLLEDQDRFERVYFSKFPGYYCT 559
+E K+++ EDG E+ G GE G +V P + G + E+Q+ + Y K ++ T
Sbjct: 362 DIELKVISLEDGREL-GVGESGEIVIRGPNIFKGYWKREKENQECWW--YDEKGRKFFRT 418
Query: 560 GDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEA 619
GD DE+G+L R+ +++ G+ ++ E+E +L V + AV+ KP E GE
Sbjct: 419 GDVGFIDEEGFLHFQDRVKEVIKYKGYTIAPFELEALLMKHEAVMDVAVIGKPDEEAGEV 478
Query: 620 LYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRK 678
F+VLK + D + + VR++I + ++ LP+T SGK++RR+LR+
Sbjct: 479 PKAFIVLKPEYRGKVD-EEDIIEWVRERISGYKRVREVEFVEELPRTASGKLLRRLLRE 536
Score = 45.2 bits (102), Expect = 0.006
Identities = 27/98 (27%), Positives = 52/98 (53%), Gaps = 2/98 (2%)
Query: 94 FGDKIAFFW-EGNSPDDYTR-ITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAV 151
FG+K A E P ++ + + ++ ++ + A+G+ KG+RKG+ V V +P ++ V
Sbjct: 30 FGEKTAIISAEPKFPSEFPESMNFLEICEVTKKLASGISRKGVRKGEHVGVCIPNSIDYV 89
Query: 152 ICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLV 189
+ + A R+ A + + S L L+D++A LV
Sbjct: 90 MTIYALWRVAATPVPINPMYKSFELEHILNDSEATTLV 127
>UniRef50_A7IKN7 Cluster: AMP-dependent synthetase and ligase; n=1;
Xanthobacter autotrophicus Py2|Rep: AMP-dependent
synthetase and ligase - Xanthobacter sp. (strain Py2)
Length = 472
Score = 85.4 bits (202), Expect = 5e-15
Identities = 59/185 (31%), Positives = 95/185 (51%), Gaps = 11/185 (5%)
Query: 499 GFPFFGVEPKILNEDGVEIEGPGE---GYLVFARPWPGMMRTLLEDQDRFERVYFSKFPG 555
G P GV ++ +D + P + G L P+ GM+ L++ D E + G
Sbjct: 291 GVPTRGVTYRLAIDDAAPVTAPADAPQGELQVRSPF-GMLG-YLDNPDLTEAAFAD---G 345
Query: 556 YYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEV 615
Y+ TGD R+ DG++ I GRI ++++ G+ ++ AE+E +L++ P V+E P
Sbjct: 346 YFRTGDVARQRPDGFVEIVGRIKEIISRGGNKIAPAEIELILSAHPAVAEVLCAGVPDPR 405
Query: 616 KGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRI 675
GEAL+ VVLK G AD ++ R++ F PD I GLP +GK +R
Sbjct: 406 LGEALHVAVVLKPGHAASADELRN---WCRERTERFKVPDAIHMVDGLPTGPTGKALRAG 462
Query: 676 LRKIA 680
+R++A
Sbjct: 463 VRELA 467
Score = 36.3 bits (80), Expect = 2.9
Identities = 16/31 (51%), Positives = 21/31 (67%)
Query: 266 SNICPPEWVAAEDPLFVLYTSGSTGKPKGVV 296
+++ PPE V++TSGSTGKPKGVV
Sbjct: 113 ADVPPPERPLLRGAALVVFTSGSTGKPKGVV 143
>UniRef50_A5Z6T7 Cluster: Putative uncharacterized protein; n=1;
Eubacterium ventriosum ATCC 27560|Rep: Putative
uncharacterized protein - Eubacterium ventriosum ATCC
27560
Length = 494
Score = 85.4 bits (202), Expect = 5e-15
Identities = 41/125 (32%), Positives = 75/125 (60%), Gaps = 3/125 (2%)
Query: 555 GYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHE 614
G T D EDG++++ GR D++N+ G ++ +E+E V+A + + E A +P P E
Sbjct: 373 GTLYTNDLGYMGEDGFVYLLGRKGDVINMGGIKIAPSEIEEVVAQNEMIKECACIPIPDE 432
Query: 615 VKGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRR 674
+ GEA F+V+ EG ++D K+L + +K+ A P +Q LP+T +GK+++R
Sbjct: 433 ITGEAPKLFIVINEGFEYDE---KSLHRFMLEKLEAIRVPKVVQVIDALPRTFNGKVIKR 489
Query: 675 ILRKI 679
+L+++
Sbjct: 490 MLKEM 494
>UniRef50_A1SPU7 Cluster: AMP-dependent synthetase and ligase; n=11;
Bacteria|Rep: AMP-dependent synthetase and ligase -
Nocardioides sp. (strain BAA-499 / JS614)
Length = 521
Score = 85.4 bits (202), Expect = 5e-15
Identities = 58/181 (32%), Positives = 92/181 (50%), Gaps = 10/181 (5%)
Query: 499 GFPFFGVEPKILNEDGVEIEGPGEGYLV--FARPWPGMMRTLLEDQDRFERVYFSKFPGY 556
G P G E K++ D E+EGPGE + A +M+ + V G+
Sbjct: 347 GVPVPGAEMKLIGPDWAEVEGPGEHGEIGEIAIKGHNVMKGYFNRPEATAEVIRD---GW 403
Query: 557 YCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVK 616
+ +GD RRDEDG+ +I R DM+ G+ + E+E VL + P VS AAV+ P E
Sbjct: 404 FRSGDLARRDEDGWYYIVDRSKDMIIRGGYNVYPREIEEVLMTHPDVSLAAVIGVPDESH 463
Query: 617 GEALYCFVVLKEGLQF-DADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRI 675
GE + V+ +G + +ADL+ ++++ + P ++ A LP T +GKI++R
Sbjct: 464 GEEIKAVVIRTDGSELTEADLI----AWSKEQMANYKYPRQVEFATSLPMTSTGKILKRE 519
Query: 676 L 676
L
Sbjct: 520 L 520
Score = 37.5 bits (83), Expect = 1.2
Identities = 22/83 (26%), Positives = 40/83 (48%)
Query: 111 TRITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAG 170
TR++Y ++ AN L+++GIR GD+VA+ P + + + GA +
Sbjct: 28 TRLSYAEVDTFANMVANLLVSRGIRPGDKVALSCPNLPYFTVVYFGILKAGATVVPLNVL 87
Query: 171 FSSDALAERLSDAKAKLLVTADG 193
+ +A L D++AK +G
Sbjct: 88 LKAREVAYHLGDSEAKAYFCFEG 110
>UniRef50_Q5L252 Cluster: AMP-binding enzyme; n=3; Bacillaceae|Rep:
AMP-binding enzyme - Geobacillus kaustophilus
Length = 531
Score = 85.0 bits (201), Expect = 6e-15
Identities = 59/180 (32%), Positives = 88/180 (48%), Gaps = 6/180 (3%)
Query: 499 GFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYC 558
G+P G E K+++E+G E+ G G+M+ +++ E + G+
Sbjct: 344 GYPMIGCEVKVVDENGEEVPKNGRAIGEVIVRSHGVMKGYWKNE---EATAATIRDGWLY 400
Query: 559 TGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGE 618
TGD DE G++ I R D++ G +S+ EVEG L P V EAAV+ PHE GE
Sbjct: 401 TGDMATVDEYGHIDIVDRKKDIIISGGENISSIEVEGALYEHPAVLEAAVIAVPHEKWGE 460
Query: 619 ALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRK 678
+ FVV++ G + L R+K+ F A + LPKT SGKI + LR+
Sbjct: 461 TPHAFVVVRPGHTVSEE---ELIAFSREKLAHFKAITGVTFVDELPKTASGKIQKVHLRR 517
Score = 50.8 bits (116), Expect = 1e-04
Identities = 43/157 (27%), Positives = 71/157 (45%), Gaps = 9/157 (5%)
Query: 258 WHEVLEGESNI-CPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDY 316
+ E L +S+ P + D +LYTSG+TG PKGV+ T ++A T ++
Sbjct: 144 YEEWLAAQSSAPVPRPMIDENDICSLLYTSGTTGNPKGVMLTHRNNYLHALVTMHHL-RV 202
Query: 317 HRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFY 376
RD Y + + G Y AN AT + PKV + ++ +++VT +
Sbjct: 203 SDRDTYLHVLPMFHVNGWGAPFYY-TANGATQIGLRKVD--PKV--IFDLVKEHQVTVMH 257
Query: 377 TAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEP 413
APT + L+ +Y E +P+ + + GS P
Sbjct: 258 MAPTVLNMLLQYY--EQYQPDVPEGVRVVIAGSAPPP 292
Score = 49.6 bits (113), Expect = 3e-04
Identities = 35/108 (32%), Positives = 51/108 (47%), Gaps = 7/108 (6%)
Query: 81 VCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRV 140
V ++ DR V +GDK A G + +TYR+L + V + ANGL G+RKGDRV
Sbjct: 6 VLHHFFDRAVAL-YGDKTAMICSGRT------VTYRELGERVSRLANGLRGLGVRKGDRV 58
Query: 141 AVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLL 188
A P LE + +G V + D L+ ++ K+L
Sbjct: 59 AYLAPNTLEMLEGFYGVFEVGGVMVPLNTRLKPDDYVFILNHSETKVL 106
>UniRef50_A3Q8J7 Cluster: AMP-dependent synthetase and ligase; n=25;
Actinomycetales|Rep: AMP-dependent synthetase and ligase
- Mycobacterium sp. (strain JLS)
Length = 546
Score = 85.0 bits (201), Expect = 6e-15
Identities = 61/196 (31%), Positives = 96/196 (48%), Gaps = 13/196 (6%)
Query: 497 TRGFPFFGVEPKILNEDGVEIEGPGE--GYLVFARPWPGMMRTLLEDQDRFERVYFSKFP 554
T+G P GVE +I+++DG + GE G L PW D +F+
Sbjct: 357 TQGRPLCGVEARIVDDDGAVLPNDGESVGELEVRGPWITGSYYRNTDDSKFQS------- 409
Query: 555 GYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHE 614
G+ TGD R D GY+ +T R D++ G +S+ E+E L + P V EAAVV P E
Sbjct: 410 GWLRTGDVGRIDPQGYITLTDRAKDVIKSGGEWISSVELENHLIAHPAVREAAVVGVPDE 469
Query: 615 VKGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRR 674
E VV++EG Q DAD ++ + K+ + P+ +P+T GK ++
Sbjct: 470 RWQERPLAAVVVQEGAQVDADELRN---FLADKVVRWWLPERWTFVDEIPRTSVGKYDKK 526
Query: 675 ILR-KIAVGDHEVGDI 689
++R + A ++V D+
Sbjct: 527 VIRARYADNAYQVADL 542
>UniRef50_A1SK97 Cluster: AMP-dependent synthetase and ligase; n=15;
Actinomycetales|Rep: AMP-dependent synthetase and ligase
- Nocardioides sp. (strain BAA-499 / JS614)
Length = 559
Score = 85.0 bits (201), Expect = 6e-15
Identities = 51/138 (36%), Positives = 73/138 (52%), Gaps = 5/138 (3%)
Query: 555 GYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHE 614
G+ TGD R DEDGY +I R DM+ G + EVE V+A+ P V++ V+ PHE
Sbjct: 422 GWMHTGDVAREDEDGYWYIVDRTKDMIVTGGFNVFPREVEDVVAAHPAVAQVGVIGTPHE 481
Query: 615 VKGEALYCFVVLKEGLQFDADLVKTLTL----LVRQKIGAFAAPDTIQNAPGLPKTRSGK 670
GEA+ VVL+ D D + +T +V+++ G+ AP + A LP T GK
Sbjct: 482 KFGEAVTAIVVLRSEAPRDEDAIGRMTAEIQEMVKERKGSVQAPKQVVVADSLPLTALGK 541
Query: 671 IMRRILR-KIAVGDHEVG 687
++ LR + GD VG
Sbjct: 542 PDKKALRAQYWTGDRAVG 559
>UniRef50_Q3W9D1 Cluster: AMP-dependent synthetase and ligase; n=1;
Frankia sp. EAN1pec|Rep: AMP-dependent synthetase and
ligase - Frankia sp. EAN1pec
Length = 908
Score = 84.6 bits (200), Expect = 8e-15
Identities = 57/180 (31%), Positives = 91/180 (50%), Gaps = 12/180 (6%)
Query: 499 GFPFFGVEPKILN-EDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYY 557
G P G+ ++++ E G+++ EG + W ++ ++ E + G+Y
Sbjct: 343 GLPVPGLGVRLVDPETGLDVGAGAEGEV-----WVRGPNVMVGYHNQPEATAAALRDGWY 397
Query: 558 CTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKG 617
TGD RRD+ GY ITGRI +++ G + EVE VL P V++ AVV +PH++ G
Sbjct: 398 RTGDLARRDDAGYFTITGRIKELIIRGGENIHPGEVEEVLRGVPGVADVAVVARPHDLLG 457
Query: 618 EALYCFVVL-KEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRIL 676
E F+V EGL D L R+++ F P+ + +P+T SGKI R +L
Sbjct: 458 EVPVAFLVPGPEGLDPD-----RLLATCRERLSYFKVPEELYEIDRIPRTASGKITRHVL 512
Score = 37.5 bits (83), Expect = 1.2
Identities = 19/48 (39%), Positives = 28/48 (58%), Gaps = 1/48 (2%)
Query: 277 EDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRD-VYW 323
+D ++LYTSG+TG+PKGV+ T L AA + + +D V W
Sbjct: 171 DDVAWMLYTSGTTGRPKGVLSTQRSCLWSVAACYAPIPGLSEQDRVLW 218
>UniRef50_A1IB03 Cluster: Long-chain-fatty-acid--CoA ligase; n=1;
Candidatus Desulfococcus oleovorans Hxd3|Rep:
Long-chain-fatty-acid--CoA ligase - Candidatus
Desulfococcus oleovorans Hxd3
Length = 577
Score = 84.6 bits (200), Expect = 8e-15
Identities = 60/185 (32%), Positives = 96/185 (51%), Gaps = 8/185 (4%)
Query: 499 GFPFFGVEPKILN-EDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPG-- 555
GFP + KI++ E G+ + GE + A P +M+ + D + V F + G
Sbjct: 395 GFPVSNTDIKIVDSETGITVLPQGEDGEI-AVNGPQVMKGYWQKPDADKEV-FREIDGKR 452
Query: 556 YYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEV 615
Y+ TGD DE+GY+ IT R D++ V G EVE VL P+V++AAVV P
Sbjct: 453 YFLTGDIGHIDENGYILITDRKKDLILVGGFNCYPREVEEVLFQHPKVAQAAVVGVPDPR 512
Query: 616 KGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRI 675
GEA+ +V L+EG+ + + ++K+ + P I+ LP + GK++RR+
Sbjct: 513 SGEAVKAYVQLREGM---TATEQEILDFCKEKLAGYKRPRAIEFRDALPTSPVGKVLRRV 569
Query: 676 LRKIA 680
L++ A
Sbjct: 570 LKEEA 574
Score = 51.6 bits (118), Expect = 7e-05
Identities = 52/203 (25%), Positives = 89/203 (43%), Gaps = 13/203 (6%)
Query: 114 TYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSS 173
T+ ++ + AN L A GI+KGDRVA+++P + + GAV ++
Sbjct: 51 TFAQVKQAADRVANFLAASGIKKGDRVAIFLPNLPHYPEIYFGILKAGAVCVTCNPLYTP 110
Query: 174 DALAERLSDAKAKLLVTADGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDR 233
L +L D+ +K++ D Y T AI++ V +C V L
Sbjct: 111 SELNYQLKDSGSKVVFCMD------HPQFYPTTV-QAIQETGV---ETVVICNVKAFLPP 160
Query: 234 VTP-GGSLKSEIKDLYNWNEETDIWWHEVLEGESNICPP-EWVAAEDPLFVLYTSGSTGK 291
V G+L ++I + +E + + E++ P E +ED ++YT G+TG
Sbjct: 161 VKRILGALLNKIPKAES-HEPGHVMYDEIMASYPAQAPDVEINPSEDLALIIYTGGTTGV 219
Query: 292 PKGVVHTTAGYLMYAAATFRYVF 314
PKG T A ++ A +V+
Sbjct: 220 PKGAALTHANFVFDVKAMDEWVY 242
>UniRef50_A0H8Z8 Cluster: AMP-dependent synthetase and ligase; n=2;
Comamonadaceae|Rep: AMP-dependent synthetase and ligase
- Comamonas testosteroni KF-1
Length = 532
Score = 84.6 bits (200), Expect = 8e-15
Identities = 45/125 (36%), Positives = 70/125 (56%), Gaps = 3/125 (2%)
Query: 555 GYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHE 614
G+ TGD + D DGYL GR +M+ VSG+ + EVE +L P +++AAV+
Sbjct: 410 GWVHTGDMGKFDADGYLTFIGRFKEMIKVSGYSVFPEEVETILIKHPAIAQAAVIGVADA 469
Query: 615 VKGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRR 674
KGE + F+V K G +AD L ++ + ++ AP ++ LP T +GK++RR
Sbjct: 470 QKGEVVRAFIVRKPGQSLEAD---GLLAWSKENMASYKAPREVRFIDALPATGAGKVLRR 526
Query: 675 ILRKI 679
+LR I
Sbjct: 527 LLRDI 531
Score = 43.2 bits (97), Expect = 0.025
Identities = 71/323 (21%), Positives = 136/323 (42%), Gaps = 33/323 (10%)
Query: 74 MEEAELNV-CYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAK 132
M E+E+ + + L RN + ++ A+ W G I++R++ + A L
Sbjct: 1 MAESEILIPLHEALRRNARQ-HPERDAYIWYGQ------HISWRQVDEASDAVAAHLQQL 53
Query: 133 GIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTAD 192
G++ G+ VA++M + ++ A +IGA+ L +L+D +A++++ AD
Sbjct: 54 GVKPGEPVALFMNNCPQYIVAHYAVQKIGAIVCPCGPLNKEHELEYQLNDLQARIIIAAD 113
Query: 193 GAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLK--SEIK-DLYN 249
V D + T +H + V + D + +L +E++ +
Sbjct: 114 ---------VLLPVVDKV--RGSTALQH----VLAVRYGDWLPARATLPLPAELQAPVQP 158
Query: 250 WNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAAT 309
+ +W +++ + P + V ++ + YTSG+TG PKG + + G Y A
Sbjct: 159 LPADVTSFW-DLMHSGARPAPVD-VGMDEVALMTYTSGTTGLPKGAM-LSFGAAAYKTAG 215
Query: 310 FRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINK 369
V DV A + I G + V P+ + AT V+ + P + +
Sbjct: 216 ASRVTGVSAEDVLLAVAPLYHIAGMSMGVNMPVHSGATCVLLH--RFDPLA--VAQALER 271
Query: 370 YKVTQFYTAPTAIRALMAHYNVE 392
Y+V+ +Y+ ALM VE
Sbjct: 272 YRVSWWYSIAPMNVALMQVPGVE 294
>UniRef50_Q8ESG9 Cluster: Long-chain fatty-acid-CoA ligase; n=1;
Oceanobacillus iheyensis|Rep: Long-chain fatty-acid-CoA
ligase - Oceanobacillus iheyensis
Length = 527
Score = 84.2 bits (199), Expect = 1e-14
Identities = 57/183 (31%), Positives = 95/183 (51%), Gaps = 12/183 (6%)
Query: 499 GFPFFGVEPKILN-EDGVEIEGPGE-GYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGY 556
G P + KI++ G E GE G L+ P +M+ +D +V + G+
Sbjct: 351 GIPIPNTDSKIVDLATGEETLPNGEVGELIIKGPQ--VMKGYWRMEDETNQVLRN---GW 405
Query: 557 YCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVK 616
TGD + D+DG+ +ITGR D++ SG+ + E+E V+ P V E A++ P + +
Sbjct: 406 LYTGDLAKMDDDGFFYITGRKKDLIIASGYNVYPVEIEDVIYKHPGVLEVAIIGVPDKYR 465
Query: 617 GEALYCFVVLKEGLQF-DADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRI 675
GE + FVVLK + DL++ R ++ +F P +++ LPKT GKI++R
Sbjct: 466 GETVKAFVVLKNNASLTEEDLIQ----YCRDRLASFKVPRSVEFLQELPKTAVGKILKRK 521
Query: 676 LRK 678
L++
Sbjct: 522 LKE 524
Score = 45.2 bits (102), Expect = 0.006
Identities = 23/79 (29%), Positives = 42/79 (53%)
Query: 114 TYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSS 173
TY++L ++ AN L GI KGDR+A+ +P + I A G + + + +
Sbjct: 49 TYQQLEKMIYSVANSLYNLGIEKGDRIALMLPNCPQYPISYFATLLCGGIIVQINPMYKA 108
Query: 174 DALAERLSDAKAKLLVTAD 192
+ L L+D++AK+++ D
Sbjct: 109 NELLHVLNDSEAKVIICLD 127
>UniRef50_Q2B4D3 Cluster: Long-chain fatty-acid-CoA ligase; n=3;
Firmicutes|Rep: Long-chain fatty-acid-CoA ligase -
Bacillus sp. NRRL B-14911
Length = 538
Score = 84.2 bits (199), Expect = 1e-14
Identities = 49/126 (38%), Positives = 67/126 (53%), Gaps = 3/126 (2%)
Query: 555 GYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHE 614
G+ TGD R DE+GYL+I R DM+ SG+ + ++E VL P V EA V+ P
Sbjct: 411 GWLYTGDIARVDEEGYLYIVDRKKDMIIASGYNIYPRDIEEVLYEHPAVQEAVVIGVPDA 470
Query: 615 VKGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRR 674
+GE + +VLK G D K + R + A+ P I+ LPKT GKI+RR
Sbjct: 471 YRGENVKAVIVLKSGKLADE---KEIMEFCRANMAAYKVPGIIEFRDALPKTSVGKILRR 527
Query: 675 ILRKIA 680
LR+ A
Sbjct: 528 ALREEA 533
Score = 39.5 bits (88), Expect = 0.31
Identities = 27/81 (33%), Positives = 38/81 (46%)
Query: 112 RITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGF 171
+ITYR+L V FA L A G KG RVAV +P + VI G + T V
Sbjct: 48 KITYRELRQHVRLFAASLQAGGFEKGGRVAVMLPNCPQYVISYYGILAAGGIVTQVNPMS 107
Query: 172 SSDALAERLSDAKAKLLVTAD 192
+ L+D+ A+ ++ D
Sbjct: 108 VEREIEYILNDSGAERMIALD 128
>UniRef50_Q1GM48 Cluster: Acetoacetyl-CoA synthase; n=3;
Proteobacteria|Rep: Acetoacetyl-CoA synthase -
Silicibacter sp. (strain TM1040)
Length = 676
Score = 84.2 bits (199), Expect = 1e-14
Identities = 63/208 (30%), Positives = 92/208 (44%), Gaps = 6/208 (2%)
Query: 501 PFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQD--RFERVYFSKFPGYYC 558
P G++ LN G +EG G LV P M L D R+ YF FP +
Sbjct: 469 PMLGLDVATLNRQGEPVEGEA-GELVCRNAHPSMPTRFLNDPGNARYRARYFETFPNVWR 527
Query: 559 TGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGE 618
GD R + G + GR D LN G + TAE+ L +++A VV + +
Sbjct: 528 QGDFTIRTKQGGYVVLGRSDATLNPGGVRIGTAEIYRQLDKIDAIADAVVVGQSVD-NDV 586
Query: 619 ALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRK 678
+ FVVL EG+ D L + +R+ P I +P+T+SGK +R
Sbjct: 587 RVILFVVLAEGVALDDGLSARIKTAIRKNASPRHVPAKILFVADIPRTKSGKTAELAVRD 646
Query: 679 IAVGDHEVGDISTLADPGVVEELFNNRP 706
+ V H V ++S LA+P + LF + P
Sbjct: 647 V-VNKHPVRNLSGLANPQAL-ALFTDHP 672
Score = 67.7 bits (158), Expect = 1e-09
Identities = 46/156 (29%), Positives = 72/156 (46%), Gaps = 7/156 (4%)
Query: 269 CPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADV 328
C P +A DPL+V+++SG+TGKPK + H G L+ + D D +
Sbjct: 283 CRP--MAFGDPLYVMFSSGTTGKPKCIEHCGGGTLLRMLVEHKLHCDLKPSDRMFYDTTC 340
Query: 329 GWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAH 388
W+ + V A LA+ A V+F+G P +P +R + I VT + I +
Sbjct: 341 NWMMWNWQV--AALASEAAIVLFDGNPMYPNRERLFDIAEAEDVTHLGVSAKYIDTSLKR 398
Query: 389 YNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYT 424
+ + T L LRV+ S G P++P + YT
Sbjct: 399 QHKPAQSYT---LDCLRVVLSTGSPLSPKGFAHVYT 431
Score = 52.8 bits (121), Expect = 3e-05
Identities = 46/182 (25%), Positives = 78/182 (42%), Gaps = 11/182 (6%)
Query: 20 SIQKYKEMYERSLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRVFVKFMEEAEL 79
+I+ + +++ S TE + FW W G + + V+F EA L
Sbjct: 62 TIRSFADLHAWSATEPQKFWP-----LAWDFCRLVGEAGPVPLLPHQDPMQVRFFPEARL 116
Query: 80 NVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDR 139
N+ +N + I F E ++R ++ ++++ A L GI GD
Sbjct: 117 NIV-ETFPKNADTR--EAIVFIGEDGRRTVWSRADLKREVEML---AAALRDAGIEAGDH 170
Query: 140 VAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGER 199
VA +P + +AV MLA A +GA+ + D + +RL KLL ADG + G +
Sbjct: 171 VAGIVPNMPQAVAAMLATASLGAIWSSCAPEGGPDVVVDRLGQIAPKLLFAADGYFYGGK 230
Query: 200 MY 201
+
Sbjct: 231 RF 232
>UniRef50_Q8L9Z5 Cluster: 4-coumarate-CoA ligase-like protein; n=9;
Magnoliophyta|Rep: 4-coumarate-CoA ligase-like protein -
Arabidopsis thaliana (Mouse-ear cress)
Length = 514
Score = 84.2 bits (199), Expect = 1e-14
Identities = 59/173 (34%), Positives = 87/173 (50%), Gaps = 8/173 (4%)
Query: 504 GVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYCTGDGV 563
G E ILNE G EI+ P V R P + + + + + + +F G++ TGD
Sbjct: 342 GQEMAILNEKG-EIQEPNNKGEVCIRG-PNVTKGYKNNPEANKAGF--EF-GWFHTGDIG 396
Query: 564 RRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALYCF 623
D DGYL + GRI +++N G +S EV+ VL + P VS+ P E GE + C
Sbjct: 397 YFDTDGYLHLVGRIKELINRGGEKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCA 456
Query: 624 VVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRIL 676
V+ +EG + +K ++ + AF P + LPKT SGKI RRI+
Sbjct: 457 VIPREGTTVTEEDIKA---FCKKNLAAFKVPKRVFITDNLPKTASGKIQRRIV 506
Score = 45.6 bits (103), Expect = 0.005
Identities = 28/80 (35%), Positives = 48/80 (60%), Gaps = 1/80 (1%)
Query: 113 ITYRKLLDLVCQFANGLLAK-GIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGF 171
+T+ +L DL+ + A+ L++ GI+ GD VA+ P +E VI LA R A + A +
Sbjct: 31 LTHARLHDLIERAASRLVSDAGIKPGDVVALTFPNTVEFVIMFLAVIRARATAAPLNAAY 90
Query: 172 SSDALAERLSDAKAKLLVTA 191
+++ LSD+ +KLL+T+
Sbjct: 91 TAEEFEFYLSDSDSKLLLTS 110
>UniRef50_O29233 Cluster: Long-chain-fatty-acid--CoA ligase; n=1;
Archaeoglobus fulgidus|Rep: Long-chain-fatty-acid--CoA
ligase - Archaeoglobus fulgidus
Length = 593
Score = 84.2 bits (199), Expect = 1e-14
Identities = 58/185 (31%), Positives = 91/185 (49%), Gaps = 11/185 (5%)
Query: 499 GFPFFGVEPKILNEDGVEIEGPGE-GYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYY 557
G P I+N + +E GE G LV A P +M+ E V+F +
Sbjct: 407 GPPIPNTYAAIINPETMEFLPIGEEGELVIAGPQ--VMKGYWNRPRETEDVFFEAGGMKW 464
Query: 558 C-TGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVK 616
TGD + DEDGY +I R+ D++ GH + E+E ++ P + E V+ P EV
Sbjct: 465 LRTGDIAKMDEDGYFYIVDRLKDIIKYKGHSVYPREIEDIMYEHPAIKEVCVIGLPDEVA 524
Query: 617 GEALYCFVVLKE---GLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMR 673
GE + FVVL E G + D++ ++++ A+ P ++ LPK+ +GK +R
Sbjct: 525 GETIKAFVVLHEDYRGKITEQDIIN----WCKERMAAYKYPRIVEFRDELPKSAAGKYLR 580
Query: 674 RILRK 678
RILR+
Sbjct: 581 RILRE 585
Score = 50.8 bits (116), Expect = 1e-04
Identities = 34/110 (30%), Positives = 54/110 (49%), Gaps = 7/110 (6%)
Query: 83 YNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAV 142
Y ++D V + D+ A + G I Y +L + +FA L GI+KGD VA+
Sbjct: 36 YEVIDE-VCQKYADRTAIIFYG------AEIKYGQLKEYTDRFATSLAKMGIKKGDVVAI 88
Query: 143 YMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTAD 192
Y P + VI + GA T + F+ + +L+D+ AK+LVT +
Sbjct: 89 YSPNCPQFVIAYYGAMKAGATVTALSPLFAPREVEYQLNDSGAKVLVTVE 138
>UniRef50_Q53FZ2 Cluster: Acyl-coenzyme A synthetase ACSM3,
mitochondrial precursor; n=80; cellular organisms|Rep:
Acyl-coenzyme A synthetase ACSM3, mitochondrial
precursor - Homo sapiens (Human)
Length = 586
Score = 84.2 bits (199), Expect = 1e-14
Identities = 46/125 (36%), Positives = 65/125 (52%), Gaps = 2/125 (1%)
Query: 556 YYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEV 615
+Y TGD D+DGY W R DD++ SG+ + EVE L P V+E+AVV P +
Sbjct: 456 FYITGDRGYMDKDGYFWFVARADDVILSSGYRIGPFEVENALNEHPSVAESAVVSSPDPI 515
Query: 616 KGEALYCFVVLKEGLQF--DADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMR 673
+GE + FVVL + L+K + V++ + P ++ LPKT SGK R
Sbjct: 516 RGEVVKAFVVLNPDYKSHDQEQLIKEIQEHVKKTTAPYKYPRKVEFIQELPKTISGKTKR 575
Query: 674 RILRK 678
LRK
Sbjct: 576 NELRK 580
Score = 71.3 bits (167), Expect = 8e-11
Identities = 54/187 (28%), Positives = 83/187 (44%), Gaps = 13/187 (6%)
Query: 282 VLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAP 341
+ +TSG++G PK HT + + + + R+ D DV W T+D GW V++P
Sbjct: 232 IFFTSGTSGYPKMTAHTHSSFGLGLSVNGRFWLDLTPSDVMWNTSDTGWAKSAWSSVFSP 291
Query: 342 LANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDL 401
A V P F ++KY +T F +APT R L+ ++T
Sbjct: 292 WIQGA-CVFTHHLPRFEPTS-ILQTLSKYPITVFCSAPTVYRMLV------QNDITSYKF 343
Query: 402 SSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTETGGHVITGLPGATPMKPGAA 461
SL+ S GEPI P + + G + I + + QTET +I G +KPG+
Sbjct: 344 KSLKHCVSAGEPITPDVTEKWRNKTGLD---IYEGYGQTET--VLICGNFKGMKIKPGSM 398
Query: 462 EKKHPVY 468
K P +
Sbjct: 399 GKPSPAF 405
Score = 43.2 bits (97), Expect = 0.025
Identities = 28/93 (30%), Positives = 46/93 (49%), Gaps = 1/93 (1%)
Query: 101 FWEGNSPDDYTRITYRKLLDLVCQFANGLL-AKGIRKGDRVAVYMPMILEAVICMLACAR 159
FW N + R ++ +L L +FAN L A +++GDRV + +P + E + +AC R
Sbjct: 83 FWWINRNGEEMRWSFEELGSLSRKFANILSEACSLQRGDRVILILPRVPEWWLANVACLR 142
Query: 160 IGAVHTVVFAGFSSDALAERLSDAKAKLLVTAD 192
G V + + RL +KA ++T D
Sbjct: 143 TGTVLIPGTTQLTQKDILYRLQSSKANCIITND 175
>UniRef50_UPI000065D652 Cluster: CDNA: FLJ21963 fis, clone HEP05583
(FLJ21963 protein).; n=1; Takifugu rubripes|Rep: CDNA:
FLJ21963 fis, clone HEP05583 (FLJ21963 protein). -
Takifugu rubripes
Length = 243
Score = 83.8 bits (198), Expect = 1e-14
Identities = 47/128 (36%), Positives = 69/128 (53%)
Query: 555 GYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHE 614
GYY T D DE+G+L+I R DD++NV+GH +S+ +E + V + AVV +
Sbjct: 50 GYYDTMDAGFMDEEGFLYIMSRSDDVINVAGHRLSSGALEESVLQHAAVVDCAVVGLEDK 109
Query: 615 VKGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRR 674
+KG VLK G++ +++ + LVR +G AA + LPKTRSGKI R
Sbjct: 110 LKGVVPLALCVLKNGVRRSSEISGEIVKLVRDTVGPVAALRKVLFVRALPKTRSGKIPRS 169
Query: 675 ILRKIAVG 682
L + G
Sbjct: 170 ALGDLVNG 177
>UniRef50_Q39P28 Cluster: AMP-dependent synthetase and ligase; n=1;
Burkholderia sp. 383|Rep: AMP-dependent synthetase and
ligase - Burkholderia sp. (strain 383) (Burkholderia
cepacia (strain ATCC 17760/ NCIB 9086 / R18194))
Length = 532
Score = 83.8 bits (198), Expect = 1e-14
Identities = 42/122 (34%), Positives = 70/122 (57%), Gaps = 3/122 (2%)
Query: 556 YYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEV 615
Y+ GD DEDG+++++ RI DM+ G + AE+E + + P V + AV+ P +
Sbjct: 403 YFAVGDAGWLDEDGFIYLSDRIKDMIISGGVNIYPAEIEAAMITHPAVQDVAVIGIPDDE 462
Query: 616 KGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRI 675
GEA+ FV L+ G+ DAD TL ++ + ++ P TI+ LP++ GK+++R
Sbjct: 463 FGEAVKAFVELRPGMSLDAD---TLQAFIQPLLASYKRPRTIEFVAELPRSTMGKVLKRE 519
Query: 676 LR 677
LR
Sbjct: 520 LR 521
>UniRef50_A3Q356 Cluster: AMP-dependent synthetase and ligase; n=10;
Actinomycetales|Rep: AMP-dependent synthetase and ligase
- Mycobacterium sp. (strain JLS)
Length = 473
Score = 83.8 bits (198), Expect = 1e-14
Identities = 61/183 (33%), Positives = 90/183 (49%), Gaps = 12/183 (6%)
Query: 497 TRGFPFFGVEPKILN-EDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPG 555
T G P GV +I++ +DG + GPGE + R M L E + G
Sbjct: 294 TVGKPVPGVRVRIVSLDDGTPL-GPGEVGEIQVRSDSVMAGYLPR-----EATSAAFADG 347
Query: 556 YYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEV 615
+Y TGD R D +G+L IT R +M+ V G ++ AEVE VL P V + AV +PH
Sbjct: 348 WYRTGDVGRLDAEGWLRITDRSKEMIKVRGFQVAPAEVEAVLHGHPAVEDCAVFGEPHPT 407
Query: 616 KGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRI 675
GEA+ V + D LT LV + ++ P + P +P+ SGK++RR+
Sbjct: 408 DGEAVVAAVTTNSDVPAD-----ELTELVAGTLASYKRPSRVVFVPAIPRLPSGKVLRRV 462
Query: 676 LRK 678
L++
Sbjct: 463 LKE 465
>UniRef50_A1SP58 Cluster: AMP-dependent synthetase and ligase; n=1;
Nocardioides sp. JS614|Rep: AMP-dependent synthetase and
ligase - Nocardioides sp. (strain BAA-499 / JS614)
Length = 508
Score = 83.8 bits (198), Expect = 1e-14
Identities = 57/176 (32%), Positives = 90/176 (51%), Gaps = 7/176 (3%)
Query: 499 GFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYC 558
G P+F E ++++ DG + GPG +++R P +M D D R + G+
Sbjct: 336 GQPWFMTEIRVVDLDGAPV-GPGGMGELYSRS-PYLMLGYYNDPDATARC--TSEDGFVT 391
Query: 559 TGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGE 618
GD VR D++GY+ I GR DM+ G + EVE VLA P V++ AVV + E GE
Sbjct: 392 CGDLVRLDDEGYVHIVGRSSDMIVSGGINIYPREVEDVLARHPSVTDVAVVGRSSEEWGE 451
Query: 619 ALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRR 674
+ +VVL G+ D V++L R+ + + P LP+ +GK+++R
Sbjct: 452 EVTAYVVLASGVTLD---VESLEAHCRESLAGYKIPRRWHVIGELPRNAAGKVVKR 504
Score = 39.5 bits (88), Expect = 0.31
Identities = 22/54 (40%), Positives = 29/54 (53%), Gaps = 2/54 (3%)
Query: 258 WHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVV--HTTAGYLMYAAAT 309
+ EVL S P V +P + YTSG+TG+PKGV+ H + Y AAT
Sbjct: 144 YDEVLAASSPEDPEYPVDETEPFCIAYTSGTTGRPKGVMISHRSRALTFYQAAT 197
Score = 35.5 bits (78), Expect = 5.0
Identities = 20/53 (37%), Positives = 30/53 (56%), Gaps = 2/53 (3%)
Query: 108 DDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILE--AVICMLACA 158
D +TY +L D + AN L+A+G+R G+ VAV + LE + C +A A
Sbjct: 31 DGERMLTYAQLGDRAARLANALVARGVRPGEHVAVCVGNRLEHPEIACGIAMA 83
>UniRef50_Q3IQ14 Cluster: Acyl-CoA synthetase II 4; n=1;
Natronomonas pharaonis DSM 2160|Rep: Acyl-CoA synthetase
II 4 - Natronomonas pharaonis (strain DSM 2160 / ATCC
35678)
Length = 546
Score = 83.8 bits (198), Expect = 1e-14
Identities = 46/119 (38%), Positives = 64/119 (53%), Gaps = 3/119 (2%)
Query: 555 GYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHE 614
G++ T D R DEDGY W+ R DDM+ G + AEVE L P V+EAAVV PHE
Sbjct: 410 GWFYTEDIARVDEDGYFWMVDRADDMIISGGENIYPAEVEDALYEHPGVAEAAVVAAPHE 469
Query: 615 VKGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMR 673
+KGEA FVV + + + ++ TL + +A P I LP++ + K+ R
Sbjct: 470 IKGEAPVAFVVPEPDADLEEEQLRDFTL---DHVATYAHPRRIFIIEELPRSATQKVQR 525
>UniRef50_Q3WJL5 Cluster: AMP-dependent synthetase and ligase; n=1;
Frankia sp. EAN1pec|Rep: AMP-dependent synthetase and
ligase - Frankia sp. EAN1pec
Length = 529
Score = 83.4 bits (197), Expect = 2e-14
Identities = 70/230 (30%), Positives = 108/230 (46%), Gaps = 12/230 (5%)
Query: 452 GATPMKPGAAEKKHPVYYSS-MDTFRPKQGWDRTVMIVHLPNKSNRTR---GFPFFGVEP 507
G +P+ PG + + S M T+ + ++ ++S R R G+P G E
Sbjct: 296 GGSPILPGRLAEAIDRFGSIFMQTYGQTESPIALCVLPRRDHESARRRESCGYPMAGTEI 355
Query: 508 KILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYCTGDGVRRDE 567
++L++ G+E+ G + P +M R G+ TGD + D+
Sbjct: 356 QVLDDVGLEVAIGTVGEICVRGPL--VMDGYWNQPAETARALRG---GWLHTGDLAKMDD 410
Query: 568 DGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALYCFVVLK 627
DGY +I GR D++ G + EVE L+S P V+ AAV+ PH+ GEA++ FVVL+
Sbjct: 411 DGYFYIVGRSKDLIITGGFNVYPREVEDALSSHPSVAMAAVIGIPHDGWGEAVHGFVVLR 470
Query: 628 EGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILR 677
A + L VR+ G AP TI+ LP T +GK +R LR
Sbjct: 471 SE---SAATAEELIEHVRRWKGPIHAPKTIEIRETLPVTANGKPDKRALR 517
Score = 41.5 bits (93), Expect = 0.076
Identities = 22/57 (38%), Positives = 32/57 (56%)
Query: 109 DYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHT 165
D R+TYR+L D + + L + G+R+GD AV + EAVI + A +G HT
Sbjct: 42 DNGRLTYRELRDEISRMIQALRSLGLRRGDGFAVLLGNQPEAVIVLAASVLLGLRHT 98
>UniRef50_Q1AV60 Cluster: Benzoate-CoA ligase family; n=3;
Bacteria|Rep: Benzoate-CoA ligase family - Rubrobacter
xylanophilus (strain DSM 9941 / NBRC 16129)
Length = 527
Score = 83.4 bits (197), Expect = 2e-14
Identities = 58/181 (32%), Positives = 87/181 (48%), Gaps = 8/181 (4%)
Query: 499 GFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYC 558
G P G E K+L+E+ +E G+L + ++ ++ + +
Sbjct: 339 GTPVPGYEAKLLDENERPVERGKPGFLYVKGD--SAAAYYWRNHEKTKKTMRGE---WLF 393
Query: 559 TGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKG- 617
GD R+DEDG+ W GR DDM+ V G +S EVE L P V EAA V P V G
Sbjct: 394 AGDWYRQDEDGFFWYEGRADDMIKVGGLWVSPVEVENTLGEHPAVMEAAAVGVP--VGGL 451
Query: 618 EALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILR 677
+ +VVL+EG DL+ L ++++ + P ++ LPKT +GKI R LR
Sbjct: 452 TRIKAYVVLREGQAPSEDLISDLQGWCKERLKRYQYPHLVEFVEELPKTVTGKIQRFKLR 511
Query: 678 K 678
+
Sbjct: 512 Q 512
Score = 70.9 bits (166), Expect = 1e-10
Identities = 61/216 (28%), Positives = 97/216 (44%), Gaps = 15/216 (6%)
Query: 258 WHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATF-RYVFDY 316
+ E+L G + P +DP F LY+SGSTGKPKG VH ++Y T+ R V
Sbjct: 148 FEELLGGGEDELSPARTHRDDPAFWLYSSGSTGKPKGAVHLHHD-IIYTCETYAREVLGI 206
Query: 317 HRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFY 376
DV + + + G + P A++V++ G P P+ I +Y+ T F+
Sbjct: 207 TEEDVTFSASKLFHAYGLGNNISFPYWAGASTVLYPGKP-VPQA--ILETIERYRPTLFF 263
Query: 377 TAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDT 436
+ PT A++ H + DLSS+R+ S E + + W + G I+D
Sbjct: 264 SVPTLYNAILNHPGAGE-----HDLSSVRLCVSAAEALPASIWRRWKETFGS---VILDG 315
Query: 437 FWQTETGGHVITGLPGATPMKPGAAEKKHPVYYSSM 472
TE I+ P +KPG++ P Y + +
Sbjct: 316 IGSTEMLHIFISNTP--ERVKPGSSGTPVPGYEAKL 349
Score = 39.9 bits (89), Expect = 0.23
Identities = 29/105 (27%), Positives = 51/105 (48%), Gaps = 6/105 (5%)
Query: 85 LLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAVYM 144
LLDRN++ G K+A D+ +TY +L V +F +GL G+R+ DRV + +
Sbjct: 15 LLDRNLEAGRSGKVAI----RCGDE--EVTYGELARRVSRFGHGLRELGVRQEDRVLLVL 68
Query: 145 PMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLV 189
+ R+GAV V ++ + D++A+++V
Sbjct: 69 NDTPAFPVAFFGAMRVGAVPIPVNTLLKAEDYRFFVEDSRARVVV 113
>UniRef50_Q0S6C5 Cluster: CoA synthetase; n=2; Rhodococcus|Rep: CoA
synthetase - Rhodococcus sp. (strain RHA1)
Length = 511
Score = 83.4 bits (197), Expect = 2e-14
Identities = 60/178 (33%), Positives = 85/178 (47%), Gaps = 8/178 (4%)
Query: 503 FGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYCTGDG 562
F + ++ DG E P E + A+ P +M L + R G+ TGD
Sbjct: 334 FFTDVDVVRPDGSSAE-PNEIGEIVAKG-PNVMLGYLNQPEATARTIVD---GWLHTGDA 388
Query: 563 VRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALYC 622
D++G+L+I R DM G + AEVE L + EAAV+ PHE GE
Sbjct: 389 GYFDDEGFLFICDRYKDMYISGGENVYPAEVEAALLKLDGIREAAVIGVPHEKWGETGMA 448
Query: 623 FVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKIA 680
FVV +G D + V+ +R+K+ F P IQ A LP+T +GKI + LRK+A
Sbjct: 449 FVVAADGTTLDEETVRA---RLREKLAGFKIPTFIQIAEALPRTATGKIRKPDLRKLA 503
Score = 54.8 bits (126), Expect = 8e-06
Identities = 60/229 (26%), Positives = 95/229 (41%), Gaps = 19/229 (8%)
Query: 249 NWNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAA 308
+W+ T + V G+ + E V +D ++Y+SG+TG PKGV+ + G +++ A
Sbjct: 134 SWSTHT---YEGVRAGQPDTRIDEQVGLDDLSVLMYSSGTTGAPKGVM-LSHGNMLWNAL 189
Query: 309 TFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIIN 368
D ++ A + I G V L N T V+ +D I
Sbjct: 190 NQLLAQDMTSKERTLSVAPLFHIGGIGGAVTPTLLNGGTVVLLRKFDAGVVLD----TIE 245
Query: 369 KYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGK 428
K ++T F+ PT I+ L H D DLSSLR + G P+ A + R
Sbjct: 246 KERITTFFAVPTMIQELWHHPRFADA-----DLSSLRAICVAGAPLPEALISPWQDR--- 297
Query: 429 ERCSIVDTFWQTETGGHVITGLPGATPMKPGAAEKKHPVYYSSMDTFRP 477
+I + TET V K G+A K+ +++ +D RP
Sbjct: 298 -DVAITQAYGLTETAPSVTMLSSADVRTKIGSAGKR--TFFTDVDVVRP 343
>UniRef50_A3VRX0 Cluster: Acetoacetyl-CoA synthase; n=1;
Parvularcula bermudensis HTCC2503|Rep: Acetoacetyl-CoA
synthase - Parvularcula bermudensis HTCC2503
Length = 651
Score = 83.4 bits (197), Expect = 2e-14
Identities = 91/355 (25%), Positives = 147/355 (41%), Gaps = 27/355 (7%)
Query: 72 KFMEEAELNVCYNLLDRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLA 131
+F EA L+ NLL R + I F E + +TR R+ V Q A+ L A
Sbjct: 82 RFFPEARLSAA-NLLLRGKADD--PAIYFRCEDHETSQWTRGELRRA---VGQLAHALKA 135
Query: 132 KGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTA 191
G+ GDRV + E+V +A +GA+ T F ++L +R S ++ K+L
Sbjct: 136 AGVTAGDRVGGVVTNRPESVAMYIATLSLGAIWTSCAPDFGVESLKQRFSQSEPKILFAV 195
Query: 192 DGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWN 251
DG R +R C ++ V+ +V L +T SL DL N
Sbjct: 196 DGFRVARR----ERNCVPIYQELLQSLPS-VERIVV---LQTLTESPSLD----DLPN-- 241
Query: 252 EETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFR 311
+ + + E++ P E + P ++Y+SG+TG PK +VH G L+ R
Sbjct: 242 --SQTYQAFLKTAETDEVPGECFPFDHPAVIVYSSGTTGAPKCIVHGAGGPLLQLMKEHR 299
Query: 312 YVFDYHRRDVYWCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYK 371
+ D D+ + WI + + LAN A +++G P P+ D ++ +
Sbjct: 300 FHCDLQPGDIMFYYTTCAWIMWNWMI--PALANGAAIALYDGNPSVPEKDMLFAFAEEIG 357
Query: 372 VTQFYTAPTAIRALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRI 426
V+ + I N DLS LR L S G P++ + + Y +
Sbjct: 358 VSHLGMSAMYIDMCRKRKMPIGEN---RDLSKLRCLMSTGSPLSTDNFEYIYASV 409
Score = 81.0 bits (191), Expect = 1e-13
Identities = 58/195 (29%), Positives = 93/195 (47%), Gaps = 7/195 (3%)
Query: 504 GVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQD--RFERVYFSKFPGYYCTGD 561
G+ + + DG I G G LV RP+P M D + ++ YF +F G + GD
Sbjct: 448 GMAVDVYDPDGNSIP-TGAGELVCTRPFPSMPVYFWNDPEGLKYRGAYFEEFEGIWTHGD 506
Query: 562 GVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKG-EAL 620
+ R G I GR D LN G M TAE+ + + +V + ++ +G E +
Sbjct: 507 LIERTAHGGYVILGRSDATLNPQGIRMGTAEIYAEVLTFNQVLNC--LAAGYQARGDEQI 564
Query: 621 YCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKIA 680
FV + G +L+ + +R+++ P + +AP LP+TRSGK + I K
Sbjct: 565 VLFVQMDAGQDLTDELIAAIKERIRRELTVNHVPAYVLSAPDLPRTRSGK-LAEIAVKCI 623
Query: 681 VGDHEVGDISTLADP 695
+ + EV + S LA+P
Sbjct: 624 LNNREVRNASALANP 638
>UniRef50_A0V7F5 Cluster: AMP-dependent synthetase and ligase; n=4;
cellular organisms|Rep: AMP-dependent synthetase and
ligase - Delftia acidovorans SPH-1
Length = 713
Score = 83.4 bits (197), Expect = 2e-14
Identities = 56/187 (29%), Positives = 93/187 (49%), Gaps = 8/187 (4%)
Query: 499 GFPFFGVEPKILN-EDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPG-- 555
G PF E ++++ E G ++ +G +V P + + D +V F + G
Sbjct: 532 GIPFMSTEARVIDPETGADVPQGEQGEIVVHGP--EVFDGYWKRPDATAQV-FMEIDGKR 588
Query: 556 YYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEV 615
++ TGD DEDGY +IT R+ M+N SG + AEVE ++ P + EA V+
Sbjct: 589 FFRTGDLGHVDEDGYYFITDRLKRMINASGFKVWPAEVESLMFRHPAIQEACVISTRDAY 648
Query: 616 KGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRI 675
+GE++ VVL+ G + + + R+ + + AP +Q LPK+ SGK+M R
Sbjct: 649 RGESVKAVVVLRAGK--EDTTAEDIIQWCRENMAVYKAPKIVQFVKALPKSGSGKVMWRQ 706
Query: 676 LRKIAVG 682
L++ G
Sbjct: 707 LQEAEAG 713
Score = 55.2 bits (127), Expect = 6e-06
Identities = 78/321 (24%), Positives = 130/321 (40%), Gaps = 23/321 (7%)
Query: 94 FGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVIC 153
+ DK A + G+S I+YR+L + + A L + G+++GDRV + M + ++
Sbjct: 186 YPDKAAIRYFGSS------ISYRELCEGTERMAAYLHSLGVQRGDRVILLMQNTPQLILA 239
Query: 154 MLACARIGAVHTVVFAGFSSDALAERLSDAKAKL-LVTADGAWRGERMYVYKRTCDDAIE 212
A R AV V ++ L ++DA AK+ + TAD A +
Sbjct: 240 HYAIFRANAVVVPVNPMNMAEELRHYITDADAKVAITTADLAPELAKASNALAPGQRLEH 299
Query: 213 KARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIWWHEVLEGESNICPPE 272
T F D + + V L + + W + ++ PP
Sbjct: 300 LVVTQFTDAFDAGVQGDDAPPVQWHDWLLTRREPAVLDGGSVHTWQQALACNDA--APPH 357
Query: 273 WVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWIT 332
V +D + YTSG+TG PKG +H + + A Y V + IT
Sbjct: 358 VVGRDDMAVLPYTSGTTGHPKGCMHPHRS-INHNAVAGSYWGSGTSETVVLAVVPMFHIT 416
Query: 333 GHTYVVYAPLANAATSVMFEGTPYFPKVDRYWS--IINKYKVTQFYTAPTAIRALMAHYN 390
G V++ + AT V+ P+ DR + +I++Y+VT + PT + L+
Sbjct: 417 GMVSVLHTAIFVGATLVV------MPRWDRELAGRLISRYQVTSWTNIPTMVIDLLG--- 467
Query: 391 VEDGNLTMPDLSSLRVLGSVG 411
N DL+SL+ +G G
Sbjct: 468 --SPNFAQFDLTSLKYIGGGG 486
>UniRef50_A6RVZ7 Cluster: Putative uncharacterized protein; n=1;
Botryotinia fuckeliana B05.10|Rep: Putative
uncharacterized protein - Botryotinia fuckeliana B05.10
Length = 552
Score = 83.4 bits (197), Expect = 2e-14
Identities = 48/128 (37%), Positives = 71/128 (55%), Gaps = 8/128 (6%)
Query: 556 YYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEV 615
YY TGD +DE+GY W R DD++N SG+ + +EVE VL S P V E+AVV P E
Sbjct: 419 YYLTGDRAYQDEEGYFWFKARKDDIINCSGYRIGPSEVEAVLQSHPGVLESAVVGIPDEE 478
Query: 616 KGEALYCFVVLKEGLQFDADLVKTLTLLVRQ----KIGAFAAPDTIQNAPG--LPKTRSG 669
+G + +VVL + +++ + L + +RQ + P I+ G LP+T +G
Sbjct: 479 RGSIIKAYVVLNQ--EYETKAPRKLQVELRQHCLNNSAPYKCPRVIEFIRGAKLPRTVTG 536
Query: 670 KIMRRILR 677
K+ R LR
Sbjct: 537 KVQRHELR 544
Score = 55.6 bits (128), Expect = 4e-06
Identities = 38/141 (26%), Positives = 66/141 (46%), Gaps = 7/141 (4%)
Query: 276 AEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHT 335
A P + +TSG+TG+PK H + + + ++W ++VGW+ G +
Sbjct: 177 ANSPAVLYFTSGTTGEPKTAQHNQISLALSSKIAGEHWCQLSPGSLFWSLSEVGWVKG-S 235
Query: 336 YVVYAPLANAATSVMFEGTP--YFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVED 393
+ V+A N +++ + TP F + I+++Y VT F PTA R L+ + E
Sbjct: 236 WAVFAAW-NHGAALLVDETPSQMFDPIHTL-RIMHEYPVTNFCATPTAYRQLVTPQSREF 293
Query: 394 GNLTMPDLSSLRVLGSVGEPI 414
P + +R+ S GE I
Sbjct: 294 AASHPPQM--IRICISAGETI 312
Score = 37.1 bits (82), Expect = 1.6
Identities = 21/77 (27%), Positives = 34/77 (44%)
Query: 113 ITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFS 172
++YR+L + Q A+ GIR GD + + + + AC R G + V +G S
Sbjct: 44 VSYRELSERSIQVASAFYELGIRPGDTIVISAARCRDWYEILCACLRSGIIICPVASGLS 103
Query: 173 SDALAERLSDAKAKLLV 189
L R+ AK +
Sbjct: 104 GLDLEHRIQKVHAKAFI 120
>UniRef50_UPI0000E88035 Cluster: acetyl-coenzyme A synthetase family
protein; n=1; Methylophilales bacterium HTCC2181|Rep:
acetyl-coenzyme A synthetase family protein -
Methylophilales bacterium HTCC2181
Length = 546
Score = 83.0 bits (196), Expect = 3e-14
Identities = 60/193 (31%), Positives = 96/193 (49%), Gaps = 12/193 (6%)
Query: 488 VHLPNKSNRTRGFPFFGVEPKILNEDGVE-IEGPGEGYLVFARPWPGMMRTLLEDQDRFE 546
VH P + + GFP G + K++N + +E I+ EG + PG+ LE E
Sbjct: 354 VHRPIRPG-SAGFPQPGHKIKLINPETLEEIKAGEEGMICVPEDDPGLF---LEYWHLPE 409
Query: 547 RVYFSKFPGYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEA 606
K G++ TGD R D DGYLW GR DD++ G+ +S E+E V + P+V++
Sbjct: 410 ETAKYKHNGWFFTGDYARYDSDGYLWFLGRKDDIIKSFGYRVSPYEIERVFKAHPQVNDC 469
Query: 607 AVVPKPHEVKGEALYCFV-VLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPK 665
AV+ EV G+ + V VL + D L R + ++ AP + P+
Sbjct: 470 AVI---GEVSGDKVLVVVYVLASESSINPD---DLVEYGRANLASYKAPKVVYITNHFPR 523
Query: 666 TRSGKIMRRILRK 678
T++GKI+R+ + +
Sbjct: 524 TKNGKILRKDINR 536
Score = 62.1 bits (144), Expect = 5e-08
Identities = 88/382 (23%), Positives = 153/382 (40%), Gaps = 46/382 (12%)
Query: 87 DRNVKNGFGDKIAFFWEGNSPDDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPM 146
DR + G + A E + + ITY +L QFA + + K RV V +P
Sbjct: 31 DRQISLKNGKQTAMIVEDDQLGS-SNITYDELAAKTNQFAEIIKNLKLEKQSRVLVRLPN 89
Query: 147 ILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAWRGERMYVYKRT 206
L I L + G + ++ + D++A +LVT W+ + T
Sbjct: 90 CLHYPIAFLGAMKAGCIAVPTSTLLTATEVIYLAKDSEAAVLVTDHETWKSLEPIAEELT 149
Query: 207 CDDAIEKARTFFKHRVDMCMVVNHLDRVTPGGSLKSEIKDLYNWNEETDIWWHEVLEGES 266
A+ F H+ + ++LD +KDL E D +
Sbjct: 150 FLKAV------FIHQASHDLSSDYLD-----------VKDL---GIEID---------KI 180
Query: 267 NICPPEWVA-AEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHR-RDVYWC 324
+C P ++DP +++YTSG+TG PKGV+H L A+ +Y F++ D
Sbjct: 181 EVCTPNPATKSDDPAYLVYTSGTTGYPKGVLHAHRALLGRNPAS-KYWFNFSAVHDRILH 239
Query: 325 TADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRA 384
T W + PL T +++EG +++ +I+K+ T F PT R
Sbjct: 240 TGKFNWTYVLGSGLMDPLYLGKTVIVYEGK---NNPNQWVDLIHKHNATIFIAVPTIYRQ 296
Query: 385 LMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTETGG 444
++ + T D+ SL S GE ++ + + +R G + I + +E
Sbjct: 297 IL-----QKTQSTKEDVPSLLHCMSAGEHLSDEVFERWNSRFGLD---IYEAVGMSEFSY 348
Query: 445 HVITGLPGATPMKPGAAEKKHP 466
++ + P++PG+A P
Sbjct: 349 YISQSV--HRPIRPGSAGFPQP 368
>UniRef50_Q0SGM6 Cluster: Long-chain-fatty-acid--CoA ligase; n=8;
Bacteria|Rep: Long-chain-fatty-acid--CoA ligase -
Rhodococcus sp. (strain RHA1)
Length = 552
Score = 83.0 bits (196), Expect = 3e-14
Identities = 47/124 (37%), Positives = 68/124 (54%), Gaps = 3/124 (2%)
Query: 555 GYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHE 614
G TGD D G++++ R DM+N SG + EVE VL P V EAAVV +P
Sbjct: 428 GRLLTGDVGFMDAQGWVYVVDRKKDMINASGFKVWPREVEDVLYRHPAVREAAVVGEPDS 487
Query: 615 VKGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRR 674
+GE + FV L+ G + D L R+++ ++ AP ++ LPKT SGKI+RR
Sbjct: 488 YRGETVAAFVSLRPGQTAETD---DLVEYCRERLASYKAPRRVEIVDELPKTASGKILRR 544
Query: 675 ILRK 678
+R+
Sbjct: 545 EMRR 548
Score = 41.9 bits (94), Expect = 0.057
Identities = 47/186 (25%), Positives = 78/186 (41%), Gaps = 16/186 (8%)
Query: 113 ITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFS 172
+ YR + +L A L G KGDR+A+Y+ + + V+ +L + G V V
Sbjct: 52 LDYRAVDELSDGVAAYLAENGFGKGDRLAIYLQNVPQFVLALLGTWKAGGV-VVPLNPMY 110
Query: 173 SDALAERLSDAKAKLLVTADGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHLD 232
D L+ L+DA +V ++ AW V +R + A T ++ + +
Sbjct: 111 RDELSHILTDAGVTAIVCSENAWADR---VAERASAAGVRIAMT----ASELDIQTSDDP 163
Query: 233 RVTPGGSLKSEIKDLYNWNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKP 292
RV GG + + + + E G P + +D V YTSG++G P
Sbjct: 164 RVF-GGVTRVRAQGVPDLLEVA-----RACAGAD--VPDPGLVPDDVALVSYTSGTSGVP 215
Query: 293 KGVVHT 298
KG +T
Sbjct: 216 KGATNT 221
>UniRef50_UPI0001556387 Cluster: PREDICTED: similar to acyl-CoA
synthetase short-chain family member 2, partial; n=1;
Ornithorhynchus anatinus|Rep: PREDICTED: similar to
acyl-CoA synthetase short-chain family member 2, partial
- Ornithorhynchus anatinus
Length = 446
Score = 82.6 bits (195), Expect = 3e-14
Identities = 39/74 (52%), Positives = 54/74 (72%), Gaps = 3/74 (4%)
Query: 31 SLTESELFWTEVAQEFQWHVAPKPGGFMKYNFDITKGRVFVKFMEEAELNVCYNLLDRNV 90
SL+ +E FW +VA+EF W P PG F+ +NFD+TKGR+F+++M+ A NVCYN+LDR V
Sbjct: 100 SLSRAE-FWGDVAKEFFWKT-PCPGPFLDHNFDVTKGRIFIEWMKGATTNVCYNVLDRIV 157
Query: 91 -KNGFGDKIAFFWE 103
GDK+AF+ E
Sbjct: 158 GDKDLGDKVAFYCE 171
Score = 73.3 bits (172), Expect = 2e-11
Identities = 28/47 (59%), Positives = 34/47 (72%)
Query: 247 LYNWNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPK 293
L WN + D+WWHE++ + C PEW AED LF+LYTSGSTGKPK
Sbjct: 337 LIPWNADVDLWWHELMGEAGDTCEPEWCDAEDVLFILYTSGSTGKPK 383
>UniRef50_A7HTP6 Cluster: AMP-dependent synthetase and ligase; n=3;
Bacteria|Rep: AMP-dependent synthetase and ligase -
Parvibaculum lavamentivorans DS-1
Length = 523
Score = 82.6 bits (195), Expect = 3e-14
Identities = 58/190 (30%), Positives = 92/190 (48%), Gaps = 9/190 (4%)
Query: 489 HLPNKSN-RTRGFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFER 547
H P K R+ G P G+E +++++ G ++ G +V +M+ D +
Sbjct: 330 HDPAKGKLRSCGIPNPGMEVRVVDDKGADVPTGEVGEIVIRGA--SIMKGYWNRADATKD 387
Query: 548 VYFSKFPGYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAA 607
G++ TGD D DGYL+I R+ DM+ G + AEVE L +++AA
Sbjct: 388 AIRD---GWFYTGDAGFFDNDGYLFIHDRVKDMIVSGGENIYPAEVENALFGHAAIADAA 444
Query: 608 VVPKPHEVKGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTR 667
V+ P E GEA+ VVLK G Q + + + +I ++ P ++ LP+
Sbjct: 445 VIGVPDEKWGEAVKAIVVLKPGEQATPE---EIIAFAKTRIASYKVPKSVDFIQALPRNP 501
Query: 668 SGKIMRRILR 677
SGKI+RR LR
Sbjct: 502 SGKILRRELR 511
Score = 39.1 bits (87), Expect = 0.41
Identities = 20/55 (36%), Positives = 29/55 (52%), Gaps = 5/55 (9%)
Query: 249 NWNEETDIWWHEVLEGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYL 303
+W D W + + E + P + +D + LYTSG+TG PKGV T A Y+
Sbjct: 141 DWTSFDD--WRDAAKSEDPMLPAD---PDDDVIQLYTSGTTGHPKGVQLTNANYM 190
>UniRef50_Q9FFE6 Cluster: AMP-binding protein; n=11;
Brassicaceae|Rep: AMP-binding protein - Arabidopsis
thaliana (Mouse-ear cress)
Length = 552
Score = 82.6 bits (195), Expect = 3e-14
Identities = 58/169 (34%), Positives = 84/169 (49%), Gaps = 4/169 (2%)
Query: 512 EDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYCTGDGVRRDEDGYL 571
E G +E GE +M L+D E+ + G++ TGD DGYL
Sbjct: 377 ESGRSVERNGETVGEIVMRGSSIMLGYLKDPVGTEKALKN---GWFYTGDVGVIHSDGYL 433
Query: 572 WITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALYCFVVLKEGLQ 631
I R D++ G +S+ EVE VL ++P V+E AVV +P GE FV LK GL
Sbjct: 434 EIKDRSKDIIITGGENVSSVEVETVLYTNPAVNEVAVVARPDVFWGETPCAFVSLKSGLT 493
Query: 632 FDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRKIA 680
V+ + R+K+ + P T+ LPKT +GK+M+ +LR+IA
Sbjct: 494 QRPTEVEMIE-YCRKKMPKYMVPKTVSFVDELPKTSTGKVMKFVLREIA 541
Score = 35.5 bits (78), Expect = 5.0
Identities = 33/119 (27%), Positives = 51/119 (42%), Gaps = 9/119 (7%)
Query: 272 EWVAAE---DPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADV 328
+W+ E DP+ + YTSG+T PKGVVH G + + + + + VY T +
Sbjct: 177 KWIRPESEWDPVVLNYTSGTTSAPKGVVHCHRGIFVMSIDSL-IDWTVPKNPVYLWTLPI 235
Query: 329 GWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMA 387
G +Y + A T+V P + R +I + VT AP + L A
Sbjct: 236 FHANGWSY-PWGIAAVGGTNVCLRKFD-APLIYR---LIRDHGVTHMCGAPVVLNMLSA 289
>UniRef50_Q80W40 Cluster: Acyl-coenzyme A synthetase O-MACS,
mitochondrial precursor; n=13; Amniota|Rep:
Acyl-coenzyme A synthetase O-MACS, mitochondrial
precursor - Mus musculus (Mouse)
Length = 580
Score = 82.6 bits (195), Expect = 3e-14
Identities = 45/124 (36%), Positives = 63/124 (50%), Gaps = 2/124 (1%)
Query: 556 YYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEV 615
+Y TGD D+DGY W GR DD++ SG+ + EVE L P V E+AVV P +
Sbjct: 450 FYVTGDRGVMDDDGYFWFVGRADDVIISSGYRIGPFEVESALIEHPAVVESAVVSSPDPI 509
Query: 616 KGEALYCFVVLKEGLQFD--ADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMR 673
+GE + F+VL + L L V+ + P ++ LPKT +GKI R
Sbjct: 510 RGEVVKAFIVLAAPYKCSNREKLTAELQDHVKNSTAPYKYPRKVEFVQELPKTITGKIKR 569
Query: 674 RILR 677
+LR
Sbjct: 570 NVLR 573
Score = 60.5 bits (140), Expect = 2e-07
Identities = 47/188 (25%), Positives = 78/188 (41%), Gaps = 13/188 (6%)
Query: 276 AEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHT 335
+++P+ + +TSG+TG PK H+ + RY D D+ W +D GWI
Sbjct: 220 SQEPMAIYFTSGTTGSPKMAQHSQGSLGIGYTLCGRYWLDLTSSDIMWNMSDTGWIKAAI 279
Query: 336 YVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGN 395
V++ A + + D + + Y +T +APT R L+ +
Sbjct: 280 GSVFSTWLRGACVFVHRMAQF--DTDIFLDTLTTYPITTLCSAPTVYRMLV------QKD 331
Query: 396 LTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTETGGHVITGLPGATP 455
L LR + GEP+NP + + G E + + + QTE G +I
Sbjct: 332 LKRYQFKRLRHCLTGGEPLNPEVLEQWKMQTGLE---LYEGYGQTEVG--IICANRKGEA 386
Query: 456 MKPGAAEK 463
+KPG+ K
Sbjct: 387 IKPGSMGK 394
Score = 45.6 bits (103), Expect = 0.005
Identities = 35/117 (29%), Positives = 60/117 (51%), Gaps = 4/117 (3%)
Query: 80 NVCYNLLDR-NVKNGFGDKIA--FFWEGNSPDDYTRITYRKLLDLVCQFANGLLAK-GIR 135
N ++LD+ ++K G++ A W N D + ++++L L + AN L G++
Sbjct: 53 NFAADVLDQWSLKEKSGERPANPALWWVNGKGDEVKWSFQELGSLSRKAANVLTKPCGLQ 112
Query: 136 KGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTAD 192
+GDRVAV +P I E + +AC R G V + + RL +KAK +V ++
Sbjct: 113 RGDRVAVILPRIPEWWLINVACMRTGLVFMPGTIQLTRKDILYRLQASKAKCIVASE 169
>UniRef50_Q18UZ8 Cluster: AMP-dependent synthetase and ligase; n=2;
Desulfitobacterium hafniense|Rep: AMP-dependent
synthetase and ligase - Desulfitobacterium hafniense
(strain DCB-2)
Length = 510
Score = 82.2 bits (194), Expect = 4e-14
Identities = 59/186 (31%), Positives = 95/186 (51%), Gaps = 7/186 (3%)
Query: 496 RTRGFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPG 555
+T G P+ G++ + ++E G E PGE + + + G M+ + + +V ++ G
Sbjct: 330 KTVGKPYEGIQVRAVHESGRTAE-PGEVGELCCKGY-GAMKGYYQLPAQTRKVLDAE--G 385
Query: 556 YYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEV 615
+ TGD R DE GY+ I GR +++ G+ + E+E V + P V EA V+ PH+
Sbjct: 386 WLHTGDLARIDERGYITIVGRKKEVIIRGGYNIYPREIEEVYYNHPEVMEACVIGLPHQD 445
Query: 616 KGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRI 675
GE F+ LK Q A L++ + KI + PD + LPK +GKI +R
Sbjct: 446 LGEQTVAFIQLKSHSQQTAALLRE---YAKGKIAKYKVPDRVLLVEQLPKLSNGKIDKRE 502
Query: 676 LRKIAV 681
L K+AV
Sbjct: 503 LGKMAV 508
>UniRef50_Q12FZ3 Cluster: Benzoate-CoA ligase family; n=5;
Burkholderiales|Rep: Benzoate-CoA ligase family -
Polaromonas sp. (strain JS666 / ATCC BAA-500)
Length = 547
Score = 82.2 bits (194), Expect = 4e-14
Identities = 45/124 (36%), Positives = 66/124 (53%)
Query: 555 GYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHE 614
G+ GD +D+DGY + R DDM+ SG+ + EVE L P V+E V+ P E
Sbjct: 423 GWNYPGDAFVQDDDGYFFYQARADDMIITSGYNVGGPEVEDALLKHPAVAECGVIGLPDE 482
Query: 615 VKGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRR 674
+G + FVVL+ G + LVK+L V+ + F P I+ LP+T +GK+ R
Sbjct: 483 ERGMIVKAFVVLRPGHEAGEALVKSLQDHVKATLAPFKYPRQIEFVGSLPRTETGKLQRF 542
Query: 675 ILRK 678
LR+
Sbjct: 543 KLRQ 546
Score = 57.6 bits (133), Expect = 1e-06
Identities = 61/206 (29%), Positives = 90/206 (43%), Gaps = 18/206 (8%)
Query: 263 EGESNICPPEWVAAEDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVY 322
+G CP AA+D + +TSG+TGKPK VHT L A R+V D+
Sbjct: 193 DGHFTPCP---TAADDIAMMAFTSGTTGKPKAAVHTHRDVLAACEAWPRHVLKARPDDIV 249
Query: 323 WCTADVGWITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAI 382
+ + + G ++ P+ A SV + Y P+V ++N+ T YTAPT
Sbjct: 250 MGSPPLAFTFGLGGMLIFPMW-AGASVYYPSVAYTPEV--MVKLMNQVGATLCYTAPTFY 306
Query: 383 RALMAHYNVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTET 442
R MA + + G + SLR+ S GE + A + G E ++D TE
Sbjct: 307 RQ-MAPFAKQLG------VPSLRICVSAGEGLPDATRQLWKDATGIE---MIDGIGATEM 356
Query: 443 GGHVITGLPGATPMKPGAAEKKHPVY 468
H+ GA ++ GA K P Y
Sbjct: 357 -FHIFISSAGA-EVRRGAIGKVVPGY 380
>UniRef50_A6G5C8 Cluster: Benzoate-CoA ligase family protein; n=1;
Plesiocystis pacifica SIR-1|Rep: Benzoate-CoA ligase
family protein - Plesiocystis pacifica SIR-1
Length = 552
Score = 82.2 bits (194), Expect = 4e-14
Identities = 65/186 (34%), Positives = 87/186 (46%), Gaps = 15/186 (8%)
Query: 504 GVEPKILNEDGVEIEGPGE-GYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYCTG-D 561
G + ++ ++ G IEG GE G LV P G+ + D+ R + F G G D
Sbjct: 371 GYDYELRDDAGKVIEGTGEIGTLVIKGPSAGLCYWRMRDKSR------ATFQGDAVVGGD 424
Query: 562 GVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALY 621
D DGY W GR DDML SG +S EVE L P V E+ VV + E
Sbjct: 425 KFMLDADGYFWYCGRGDDMLKCSGVYVSPVEVENALIGHPAVRESGVVGYRDDAGLEKTM 484
Query: 622 CFVVLKEG--LQFD-----ADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRR 674
FV + + Q D A L + + R +I AF AP I+ LP+T +GKI R
Sbjct: 485 AFVEVHDDHRAQLDDEASEAALAEAIIEHCRGQIAAFKAPRRIEFVDDLPRTETGKIRRA 544
Query: 675 ILRKIA 680
LR++A
Sbjct: 545 ALRELA 550
Score = 49.2 bits (112), Expect = 4e-04
Identities = 47/170 (27%), Positives = 69/170 (40%), Gaps = 8/170 (4%)
Query: 283 LYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVGWITGHTYVVYAPL 342
L +SGSTG PK VVH ++ A + R D + + + PL
Sbjct: 197 LSSSGSTGNPKCVVHMHHDFVWNTIAYAQRTLKLTRDDRTLAAPKLFFGYALASNMLFPL 256
Query: 343 ANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVEDGNLTMPDLS 402
+ + V+ P+ K Y+ ++ +Y+ TQF T PT I ++A E+G L
Sbjct: 257 SVGGSCVLL---PHRVKPADYFELLARYEATQFVTVPTTIAKMVA--AAEEGAAEGKKLD 311
Query: 403 SLRVLGSVGEPINPAAWLWYYTRIGKERCSIVDTFWQTETGGHVITGLPG 452
L L S GE + + + R G E I D E IT PG
Sbjct: 312 KLHSLISAGEALPARVYRSWRDRFGAE---IYDGIGSAEMFHVYITNRPG 358
Score = 42.3 bits (95), Expect = 0.043
Identities = 32/120 (26%), Positives = 48/120 (40%), Gaps = 3/120 (2%)
Query: 79 LNVCYNLLDRNVKNGFGDKIAFFWEGN---SPDDYTRITYRKLLDLVCQFANGLLAKGIR 135
LN+ LD + G GDK A + G+ + D ++Y +L+ C+ N L G+
Sbjct: 16 LNMVQFFLDARLDEGLGDKAAIHYHGDPALAADPGRTLSYAELVADSCRVTNLLRELGLG 75
Query: 136 KGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSSDALAERLSDAKAKLLVTADGAW 195
DRV + MP V R G V A + A L A+ K ++ W
Sbjct: 76 IEDRVLILMPDTPAWVAAYFGILRAGCVAVPANAWLKAKDYAYYLEYARPKAVIVDASIW 135
>UniRef50_Q399N2 Cluster: AMP-dependent synthetase and ligase; n=55;
Bacteria|Rep: AMP-dependent synthetase and ligase -
Burkholderia sp. (strain 383) (Burkholderia cepacia
(strain ATCC 17760/ NCIB 9086 / R18194))
Length = 609
Score = 81.8 bits (193), Expect = 6e-14
Identities = 65/202 (32%), Positives = 96/202 (47%), Gaps = 13/202 (6%)
Query: 499 GFPFFGVEPKILNEDGVEIEGPGEGYLVFA----RPWPGMMRTLLEDQDRFERVYFSKFP 554
G P G +L+ DG+ + GE L RP G+M + D ++
Sbjct: 405 GRPLPGYRIALLDPDGMPVT-EGEVALPIGADVTRP-VGLMNGYANNPDA---TAYAMRD 459
Query: 555 GYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHE 614
G+Y T D R +DGY GR DD+ S + +S E+E VL P ++EAAVVP P
Sbjct: 460 GHYRTSDIAMRGDDGYYVYIGRADDVFKSSDYRLSPFELESVLIEHPAIAEAAVVPSPDP 519
Query: 615 VKGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRR 674
V+ F+ L++G + +L + R+K+ + +Q A LPKT SGKI R
Sbjct: 520 VRLSVPKTFITLRQGYEESPELALEIFRFSREKLAPYKRIRRLQFAE-LPKTISGKIRRV 578
Query: 675 ILRKIAVGDHEVGDISTLADPG 696
LR+ + E GD ++ PG
Sbjct: 579 ELRRREI---ERGDDASERMPG 597
Score = 54.4 bits (125), Expect = 1e-05
Identities = 59/200 (29%), Positives = 85/200 (42%), Gaps = 18/200 (9%)
Query: 271 PEWVAAEDPLFVLY-TSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHRRDVYWCTADVG 329
P+ V + +LY TSG+T KPK V HT Y + +T Y D++W + G
Sbjct: 228 PDAVTQSNEAMLLYFTSGTTSKPKLVEHTHRTYPVGHLSTM-YWIGLQPGDIHWNISSPG 286
Query: 330 WITGHTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHY 389
W +AP A F + PKV + KY+VT PT R L+
Sbjct: 287 WAKHAWSCFFAPWNAQACVFAFNYARFEPKV--VLDALVKYQVTTLCAPPTVWRMLVQQ- 343
Query: 390 NVEDGNLTMPDLSSLRVLGSVGEPINPAAWLWYYTRIGKE-RCSIVDTFWQTETGGHVIT 448
L D+ ++G+ GEP+NP R+ K +I D + QTET +I
Sbjct: 344 -----PLASFDVKLREIVGA-GEPLNPE----IIERVKKAWGIAIRDGYGQTET-TCLIG 392
Query: 449 GLPGATPMKPGAAEKKHPVY 468
PG P+ G+ + P Y
Sbjct: 393 NSPG-QPVVAGSMGRPLPGY 411
Score = 35.9 bits (79), Expect = 3.8
Identities = 19/76 (25%), Positives = 39/76 (51%)
Query: 114 TYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGFSS 173
++ ++ + + AN L + G+ +GDR+ + +P +E MLA ++GA+ S
Sbjct: 109 SFAQMSERSSRIANWLRSIGVVRGDRILLMLPNRVELWDAMLAAMKLGAIVLPATTQLSP 168
Query: 174 DALAERLSDAKAKLLV 189
D + +R+ AK +
Sbjct: 169 DDVRDRVQIGGAKYAI 184
>UniRef50_Q1GWM8 Cluster: AMP-dependent synthetase and ligase; n=3;
Sphingomonadales|Rep: AMP-dependent synthetase and
ligase - Sphingopyxis alaskensis (Sphingomonas
alaskensis)
Length = 510
Score = 81.8 bits (193), Expect = 6e-14
Identities = 64/189 (33%), Positives = 94/189 (49%), Gaps = 10/189 (5%)
Query: 491 PNKSNRTRGFPFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYF 550
P+K + T G P G K+++EDG E+ G +V P MM D + +++
Sbjct: 325 PDKLH-TVGKPAPGHVAKVIDEDGNELPQGSVGEIVGRSP--AMMTGYNNRPDATKAMHW 381
Query: 551 SKFPG--YYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAV 608
G +Y GD R DEDG+L + R DM+ G + +++E +L +D RV EAAV
Sbjct: 382 YDSEGQLFYRHGDIGRIDEDGFLTLMDRAKDMIISGGFNIFPSDLEAILLADERVVEAAV 441
Query: 609 VPKPHEVKGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRS 668
V P E GE FVVLK G DA+ V+ K+G I+ LP++
Sbjct: 442 VGMPSEEWGETPVAFVVLKPGA--DAESVRE---TCNAKVGKTQRLSAIRQVDELPRSPI 496
Query: 669 GKIMRRILR 677
GK+++R LR
Sbjct: 497 GKVLKRELR 505
Score = 35.1 bits (77), Expect = 6.6
Identities = 12/30 (40%), Positives = 21/30 (70%)
Query: 271 PEWVAAEDPLFVLYTSGSTGKPKGVVHTTA 300
P + +D ++Y+SG+TG PKG++H+ A
Sbjct: 158 PAAIGPDDGFNIIYSSGTTGTPKGIIHSHA 187
>UniRef50_Q13HM2 Cluster: Putative AMP-dependent synthetase and
ligase; n=1; Burkholderia xenovorans LB400|Rep: Putative
AMP-dependent synthetase and ligase - Burkholderia
xenovorans (strain LB400)
Length = 523
Score = 81.8 bits (193), Expect = 6e-14
Identities = 60/234 (25%), Positives = 106/234 (45%), Gaps = 11/234 (4%)
Query: 450 LPGATPMKPGAAEKKHPVYYSSM--DTFRPKQGWDRTVMIVHLPNKSNRTRGFPFFGVEP 507
L G PM A + ++ + + +GW + + T G P FG +
Sbjct: 286 LYGGAPMTSQTAAAMAKTFPNTRMYEIYGMSEGWCTLAYPEDRAHGRSSTVGKPVFGGDI 345
Query: 508 KILNEDGVEIEGPGEGYLVFARPWP-GMMRTLLEDQDRFERVYFSKFPG--YYCTGDGVR 564
+++ +G E+ +G L W G+M+ L D R + + G Y +GD
Sbjct: 346 CVIDPEGRELPPGEQGELA---GWSAGLMKGYLGDPQRTADIVWKGPHGRTYLRSGDIGY 402
Query: 565 RDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALYCFV 624
D +G+ ++ GR+ DM+ G + +++E V P V+EAA + PH+ GE V
Sbjct: 403 MDTEGFFFVNGRVKDMIISGGINVFASDIEEVFMQHPAVAEAAAIGIPHDKWGETPIVMV 462
Query: 625 VLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRK 678
+L++G Q DA +K ++G F ++ P+ GKI++R+LR+
Sbjct: 463 ILRQGHQIDAVALKEWG---NHRLGKFQRVSEVKFVDDFPRANYGKILKRVLRE 513
>UniRef50_Q0RV51 Cluster: Probable synthetase/ligase; n=1;
Rhodococcus sp. RHA1|Rep: Probable synthetase/ligase -
Rhodococcus sp. (strain RHA1)
Length = 472
Score = 81.8 bits (193), Expect = 6e-14
Identities = 76/246 (30%), Positives = 112/246 (45%), Gaps = 10/246 (4%)
Query: 441 ETGGHVITGLPGATPMKPGAAEKKHPVYYSSMDTFRPKQGWDRTVMIVHLPNKSNRTRGF 500
ET +V +G GA + AE + M F + + T P+ T G
Sbjct: 236 ETLRYVASG--GAAIPRHLVAEVRENFSAELMAVFGASETYVTTATRPGAPDDILATDGE 293
Query: 501 PFFGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYCTG 560
P GV+ I++E G E+ EG +V P + L D D R + +Y G
Sbjct: 294 PLPGVQVAIVDESGRELPRGEEGEIVTRGPQ--VFLGYLGDPDLTHRAFRGD---WYRFG 348
Query: 561 DGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEAL 620
D R DE+G L +TGRI D++ G +S EVE +L + P V+ AAVV P GE
Sbjct: 349 DLGRIDENGMLHVTGRIKDIVIRGGENISVREVEELLINHPNVASAAVVGYPDPRLGERC 408
Query: 621 YCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRK-I 679
VV G + DL + + LV + + + P+ ++ +P T +GKI + LR+ I
Sbjct: 409 CAVVVPTAGT--EVDLQELNSYLVGRGLAKYKLPERLEVFDEMPMTATGKIRKADLRRQI 466
Query: 680 AVGDHE 685
A D E
Sbjct: 467 AGSDDE 472
>UniRef50_A5V1C7 Cluster: AMP-dependent synthetase and ligase
precursor; n=7; Bacteria|Rep: AMP-dependent synthetase
and ligase precursor - Roseiflexus sp. RS-1
Length = 506
Score = 81.8 bits (193), Expect = 6e-14
Identities = 60/187 (32%), Positives = 90/187 (48%), Gaps = 11/187 (5%)
Query: 503 FGVEPKILNEDGVEIEGPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPGYYCTGDG 562
FGVE IL+E G E + GE V R P + E+ F+ G++ TGD
Sbjct: 328 FGVEVTILDEQGAE-KARGERGEVAVRG-PNVFDGY-ENNPEATAAAFTN--GWFRTGDQ 382
Query: 563 VRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEVKGEALYC 622
R D++GYLW+TGR+ +++N G +S E++ VL P V+EA PH GE ++
Sbjct: 383 GRIDDNGYLWLTGRLKELINRGGEKISPLEIDDVLLRHPAVAEAVAFAAPHRTLGEEVHA 442
Query: 623 FVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRRILRK-IAV 681
VVL+ A + L + F P I P +P+ +GK+ R + K + +
Sbjct: 443 AVVLRA-----AATERELRDHCAAFLADFKVPRVIHILPEIPRGATGKVQRIGMAKLLGL 497
Query: 682 GDHEVGD 688
D GD
Sbjct: 498 TDDSSGD 504
Score = 39.9 bits (89), Expect = 0.23
Identities = 37/143 (25%), Positives = 63/143 (44%), Gaps = 14/143 (9%)
Query: 277 EDPLFVLYTSGSTGKPKGVVHTTAGYLMYAAATFRYVFDYHR---RDVYWCTADVGWITG 333
+D +L+TSG+T +PK V + A+ R + D +R D C + I G
Sbjct: 151 DDVALILHTSGTTSRPKRVPLRQRNLI----ASARNIIDAYRLSPDDRALCVMPLFHIHG 206
Query: 334 HTYVVYAPLANAATSVMFEGTPYFPKVDRYWSIINKYKVTQFYTAPTAIRALMAHYNVED 393
+ APLA+ + V+ P F + R+W + ++ T F PT + L+A +
Sbjct: 207 IVATLLAPLASGGSVVL---PPGFDAM-RFWGWLTAFRPTWFSAVPTMHQMLLAR---AE 259
Query: 394 GNLTMPDLSSLRVLGSVGEPINP 416
+ + LR + S P+ P
Sbjct: 260 RQIAAIRAAPLRFIRSSSAPLPP 282
>UniRef50_A5UV13 Cluster: AMP-dependent synthetase and ligase; n=7;
Bacteria|Rep: AMP-dependent synthetase and ligase -
Roseiflexus sp. RS-1
Length = 591
Score = 81.8 bits (193), Expect = 6e-14
Identities = 59/182 (32%), Positives = 93/182 (51%), Gaps = 11/182 (6%)
Query: 499 GFPFFGVEPKILN-EDGVEIE--GPGEGYLVFARPWPGMMRTLLEDQDRFERVYFSKFPG 555
G P V+ KI++ E G +I EG LV P +M+ + E + G
Sbjct: 393 GIPLPDVDAKIIDLETGEDIPFGSDKEGELVVKGPM--VMKGYWNRPEETEATFTPD--G 448
Query: 556 YYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHEV 615
+ TGD + DE+GY +I R DM+ SG+ + +VE VL + P+V EA VV P+
Sbjct: 449 WLRTGDICKVDEEGYFYIVDRKKDMMIASGYKVLPRDVEEVLFTHPKVLEAVVVGIPNPA 508
Query: 616 KG-EALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRR 674
+G + + F+VLK G AD ++ +Q++ + P ++ LPKT GK++RR
Sbjct: 509 RGDDTIKAFIVLKPGETATADEIRE---YCKQQLAPYKVPREVEFRAELPKTMVGKVLRR 565
Query: 675 IL 676
+L
Sbjct: 566 VL 567
Score = 58.8 bits (136), Expect = 5e-07
Identities = 51/188 (27%), Positives = 85/188 (45%), Gaps = 11/188 (5%)
Query: 112 RITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVVFAGF 171
++TY+KL ++V +FAN L G+RKGDRVA+ +P VI A RIGA+ +
Sbjct: 63 KMTYQKLSEMVDRFANALYQLGVRKGDRVALMLPNSPHYVIAFFAAMRIGAIIVNNNPTY 122
Query: 172 SSDALAERLSDAKAKLLVTADGAWRGERMYVYKRTCDDAIEKARTFFKHRVDMCMVVNHL 231
++ L +L D+ ++ +V + Y + R H D + L
Sbjct: 123 TARELKHQLVDSGSETIVLLN------LFYPRLQEIRSETPVKRVIVAHIYD---TLGPL 173
Query: 232 DRVTPGGSLKSEIKDLYNWNEETDIW-WHEVLEGESNICPPEWVAAEDPLFVLYTSGSTG 290
R +S+ D + + ++ ++ + +LE P V ED + YT G+TG
Sbjct: 174 SRFLVHAK-QSKQPDWVDVSRDSSVYLFQHLLERYGPNPPAVEVLPEDIALLQYTGGTTG 232
Query: 291 KPKGVVHT 298
PK + T
Sbjct: 233 LPKAAMLT 240
>UniRef50_A1GFR6 Cluster: AMP-dependent synthetase and ligase; n=3;
cellular organisms|Rep: AMP-dependent synthetase and
ligase - Salinispora arenicola CNS205
Length = 5162
Score = 81.8 bits (193), Expect = 6e-14
Identities = 45/122 (36%), Positives = 68/122 (55%), Gaps = 4/122 (3%)
Query: 555 GYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVVPKPHE 614
G++ TGD RRD GYL I+GRI +++ G + EVE VL + P V++ AV PHE
Sbjct: 390 GWFRTGDLARRDGAGYLTISGRIKELVIRGGENIHPVEVEAVLRTVPGVADVAVAGVPHE 449
Query: 615 VKGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSGKIMRR 674
GE +V+ FD V++L R+++ A+ P + +P+T SGK+ RR
Sbjct: 450 TLGEVPVAYVIPGPD-GFD---VESLVTRCREQLSAYKVPHQVHEVASIPRTASGKVQRR 505
Query: 675 IL 676
+L
Sbjct: 506 LL 507
Score = 40.7 bits (91), Expect = 0.13
Identities = 25/83 (30%), Positives = 39/83 (46%)
Query: 108 DDYTRITYRKLLDLVCQFANGLLAKGIRKGDRVAVYMPMILEAVICMLACARIGAVHTVV 167
DD +TY L + A L G+++GDRVA+++ + V LA R G V +
Sbjct: 36 DDRRAVTYADLEARTRRLAGHLRGLGVKRGDRVAIWLRQSVSTVESYLAVVRAGGVGVPL 95
Query: 168 FAGFSSDALAERLSDAKAKLLVT 190
+ L LSD+ A ++T
Sbjct: 96 NPDAAQAELEYLLSDSGATAVIT 118
>UniRef50_P38137 Cluster: Peroxisomal-coenzyme A synthetase; n=3;
Saccharomycetaceae|Rep: Peroxisomal-coenzyme A
synthetase - Saccharomyces cerevisiae (Baker's yeast)
Length = 543
Score = 81.8 bits (193), Expect = 6e-14
Identities = 40/127 (31%), Positives = 72/127 (56%), Gaps = 3/127 (2%)
Query: 550 FSKFPGYYCTGDGVRRDEDGYLWITGRIDDMLNVSGHLMSTAEVEGVLASDPRVSEAAVV 609
F+K Y+ TGD D +G+L +TGRI +++N G +S E++G++ S P++ EA
Sbjct: 406 FTKRENYFRTGDQGYFDPEGFLVLTGRIKELINRGGEKISPIELDGIMLSHPKIDEAVAF 465
Query: 610 PKPHEVKGEALYCFVVLKEGLQFDADLVKTLTLLVRQKIGAFAAPDTIQNAPGLPKTRSG 669
P ++ G+ + +VLK+G + + L +++ + +F P + LPKT +G
Sbjct: 466 GVPDDMYGQVVQAAIVLKKG---EKMTYEELVNFLKKHLASFKIPTKVYFVDKLPKTATG 522
Query: 670 KIMRRIL 676
KI RR++
Sbjct: 523 KIQRRVI 529
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.321 0.138 0.434
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 863,495,288
Number of Sequences: 1657284
Number of extensions: 38559097
Number of successful extensions: 87928
Number of sequences better than 10.0: 500
Number of HSP's better than 10.0 without gapping: 2490
Number of HSP's successfully gapped in prelim test: 434
Number of HSP's that attempted gapping in prelim test: 76359
Number of HSP's gapped (non-prelim): 10136
length of query: 714
length of database: 575,637,011
effective HSP length: 106
effective length of query: 608
effective length of database: 399,964,907
effective search space: 243178663456
effective search space used: 243178663456
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.8 bits)
S2: 76 (34.7 bits)
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