Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA000696-TA|BGIBMGA000696-PA|IPR001849|Pleckstrin-like,
IPR001895|Guanine-nucleotide dissociation stimulator CDC25,
IPR008937|Ras guanine nucleotide exchange factor
(576 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_Q16MY3 Cluster: Ral guanine nucleotide exchange factor ... 469 e-131
UniRef50_UPI00015B534D Cluster: PREDICTED: similar to CG5522-PD;... 466 e-130
UniRef50_Q0E949 Cluster: CG5522-PA, isoform A; n=5; Endopterygot... 438 e-121
UniRef50_O15059 Cluster: Ral GEF with PH domain and SH3-binding ... 393 e-108
UniRef50_Q7Q955 Cluster: ENSANGP00000013079; n=1; Anopheles gamb... 334 5e-90
UniRef50_A7SU64 Cluster: Predicted protein; n=1; Nematostella ve... 322 2e-86
UniRef50_Q4T1D4 Cluster: Chromosome undetermined SCAF10661, whol... 287 7e-76
UniRef50_Q5RH52 Cluster: Novel RasGEF domain containing protein;... 195 2e-48
UniRef50_UPI0000E478B1 Cluster: PREDICTED: similar to RALGPS1 pr... 188 3e-46
UniRef50_Q5C2U2 Cluster: SJCHGC07188 protein; n=1; Schistosoma j... 155 3e-36
UniRef50_Q5B8H1 Cluster: Putative uncharacterized protein; n=1; ... 140 1e-31
UniRef50_Q9GQC2 Cluster: Ras guanine nucleotide exchange factor ... 139 2e-31
UniRef50_P28818 Cluster: Guanine nucleotide-releasing protein; n... 138 3e-31
UniRef50_O14827 Cluster: Ras protein-specific guanine nucleotide... 133 1e-29
UniRef50_UPI00015B5B5D Cluster: PREDICTED: similar to conserved ... 132 3e-29
UniRef50_P26674 Cluster: Protein ste6; n=1; Schizosaccharomyces ... 130 7e-29
UniRef50_Q54XL4 Cluster: Putative uncharacterized protein; n=1; ... 130 1e-28
UniRef50_Q23867 Cluster: Aimless RasGEF; n=3; Dictyostelium disc... 129 2e-28
UniRef50_Q13972 Cluster: Guanine nucleotide-releasing protein; n... 129 2e-28
UniRef50_Q555T3 Cluster: Ras guanine nucleotide exchange factor;... 128 4e-28
UniRef50_Q54H67 Cluster: Ras guanine nucleotide exchange factor;... 128 4e-28
UniRef50_Q552M5 Cluster: RasGEF domain-containing protein; n=2; ... 127 9e-28
UniRef50_Q8IS10 Cluster: Nucleotide exchange factor RasGEF P; n=... 126 2e-27
UniRef50_A2R650 Cluster: Similarity: N-terminal half differs fro... 126 2e-27
UniRef50_Q0UTD8 Cluster: Putative uncharacterized protein; n=1; ... 125 4e-27
UniRef50_Q55CK1 Cluster: Ras guanine nucleotide exchange factor;... 124 5e-27
UniRef50_UPI000049A5AB Cluster: Ras guanine nucleotide exchange ... 123 1e-26
UniRef50_Q54FF3 Cluster: Ras guanine nucleotide exchange factor;... 123 1e-26
UniRef50_Q0UD52 Cluster: Putative uncharacterized protein; n=1; ... 122 3e-26
UniRef50_UPI0000499791 Cluster: Ras guanine nucleotide exchange ... 121 6e-26
UniRef50_UPI0000E47C73 Cluster: PREDICTED: similar to conserved ... 120 8e-26
UniRef50_Q55AB0 Cluster: Ras guanine nucleotide exchange factor;... 120 8e-26
UniRef50_A6R7Z9 Cluster: Putative uncharacterized protein; n=1; ... 120 8e-26
UniRef50_A3LZZ6 Cluster: Predicted protein; n=2; Pichia|Rep: Pre... 120 1e-25
UniRef50_Q54YQ2 Cluster: Ras guanine nucleotide exchange factor;... 119 2e-25
UniRef50_Q54H95 Cluster: Putative uncharacterized protein; n=1; ... 118 4e-25
UniRef50_UPI0000499F54 Cluster: Ras guanine nucleotide exchange ... 118 6e-25
UniRef50_Q550U8 Cluster: Ras guanine nucleotide exchange factor;... 118 6e-25
UniRef50_Q875L6 Cluster: Guanyl nucleotide exchange factor Sql2;... 117 1e-24
UniRef50_Q6C867 Cluster: Similarities with sp|P43069 Candida alb... 116 2e-24
UniRef50_P43069 Cluster: Cell division control protein 25; n=5; ... 116 2e-24
UniRef50_A7SLX0 Cluster: Predicted protein; n=1; Nematostella ve... 115 4e-24
UniRef50_A1CGW5 Cluster: Ras guanine-nucleotide exchange protein... 115 4e-24
UniRef50_Q555R4 Cluster: Ras guanine nucleotide exchange factor;... 114 5e-24
UniRef50_UPI0000498A32 Cluster: Ras guanine nucleotide exchange ... 114 7e-24
UniRef50_Q02342 Cluster: Cell division control protein 25; n=1; ... 114 7e-24
UniRef50_Q7S0V9 Cluster: Putative uncharacterized protein NCU097... 113 9e-24
UniRef50_P26675 Cluster: Protein son of sevenless; n=6; Endopter... 113 9e-24
UniRef50_Q55FD8 Cluster: RasGEF domain-containing protein; n=2; ... 113 1e-23
UniRef50_P04821 Cluster: Cell division control protein 25; n=2; ... 113 1e-23
UniRef50_Q55GH9 Cluster: RasGEF domain-containing protein; n=1; ... 113 2e-23
UniRef50_Q9USU1 Cluster: Exchange factor Cdc25p-like; n=1; Schiz... 113 2e-23
UniRef50_Q4WNQ3 Cluster: Ras guanine-nucleotide exchange protein... 112 2e-23
UniRef50_Q8MVR0 Cluster: Cyclic GMP-binding protein D; n=2; Dict... 111 4e-23
UniRef50_Q54RZ8 Cluster: RasGEF; n=2; Dictyostelium discoideum|R... 111 4e-23
UniRef50_Q5JUE6 Cluster: Rap guanine nucleotide exchange factor ... 111 4e-23
UniRef50_Q13905 Cluster: Rap guanine nucleotide exchange factor ... 111 4e-23
UniRef50_Q6C637 Cluster: YlCDC25 protein; n=2; Yarrowia lipolyti... 111 5e-23
UniRef50_Q5K7Q6 Cluster: Putative uncharacterized protein; n=1; ... 111 5e-23
UniRef50_Q7JTG3 Cluster: Nucleotide exchange factor RasGEF L; n=... 111 6e-23
UniRef50_A4RFZ9 Cluster: Putative uncharacterized protein; n=2; ... 111 6e-23
UniRef50_UPI0000ECA662 Cluster: Rap guanine nucleotide exchange ... 109 1e-22
UniRef50_Q07889 Cluster: Son of sevenless homolog 1; n=70; cellu... 108 3e-22
UniRef50_UPI000049846E Cluster: Ras guanine nucleotide exchange ... 108 5e-22
UniRef50_A2RRV5 Cluster: Histone H2A; n=2; Danio rerio|Rep: Hist... 107 6e-22
UniRef50_Q54WL2 Cluster: RasGEF domain-containing protein; n=3; ... 106 2e-21
UniRef50_Q9N5D3 Cluster: Drosophila sos homolog protein 1; n=3; ... 105 2e-21
UniRef50_Q12967 Cluster: Ral guanine nucleotide dissociation sti... 105 4e-21
UniRef50_Q75AF6 Cluster: ADL038Wp; n=1; Eremothecium gossypii|Re... 104 6e-21
UniRef50_A7TNK1 Cluster: Putative uncharacterized protein; n=1; ... 104 6e-21
UniRef50_UPI0000498DA7 Cluster: Ras guanine nucleotide exchange ... 104 7e-21
UniRef50_Q7PSV2 Cluster: ENSANGP00000005326; n=1; Anopheles gamb... 103 2e-20
UniRef50_A7SA05 Cluster: Predicted protein; n=1; Nematostella ve... 102 2e-20
UniRef50_Q6CRG2 Cluster: Kluyveromyces lactis strain NRRL Y-1140... 101 4e-20
UniRef50_A7TRY3 Cluster: Putative uncharacterized protein; n=1; ... 101 4e-20
UniRef50_A2EWA8 Cluster: RasGEF domain containing protein; n=1; ... 101 7e-20
UniRef50_Q5T5Z4 Cluster: Ral GEF with PH domain and SH3 binding ... 101 7e-20
UniRef50_Q3MIN7 Cluster: Ral guanine nucleotide dissociation sti... 100 1e-19
UniRef50_UPI00004996A3 Cluster: Ras guanine nucleotide exchange ... 99 2e-19
UniRef50_Q4PAN1 Cluster: Putative uncharacterized protein; n=1; ... 99 2e-19
UniRef50_UPI00015B5730 Cluster: PREDICTED: similar to guanine-nu... 99 4e-19
UniRef50_Q4T188 Cluster: Chromosome undetermined SCAF10698, whol... 99 4e-19
UniRef50_UPI0000519C35 Cluster: PREDICTED: similar to C3G CG3126... 98 5e-19
UniRef50_A2QFY6 Cluster: Contig An03c0040, complete genome; n=2;... 98 5e-19
UniRef50_A2EJW8 Cluster: RasGEF domain containing protein; n=1; ... 98 6e-19
UniRef50_Q6FVA6 Cluster: Candida glabrata strain CBS138 chromoso... 98 6e-19
UniRef50_UPI0000D55549 Cluster: PREDICTED: similar to CG3126-PA,... 97 8e-19
UniRef50_UPI000049A2E5 Cluster: Ras guanine nucleotide exchange ... 97 8e-19
UniRef50_UPI00006A1942 Cluster: Ral GEF with PH domain and SH3 b... 97 8e-19
UniRef50_Q19770 Cluster: Putative uncharacterized protein; n=2; ... 97 8e-19
UniRef50_Q5K6X7 Cluster: Cell division control protein 25, putat... 97 8e-19
UniRef50_Q29IL8 Cluster: GA16131-PA; n=1; Drosophila pseudoobscu... 97 1e-18
UniRef50_Q9Y4G8 Cluster: Rap guanine nucleotide exchange factor ... 97 1e-18
UniRef50_UPI00015616A3 Cluster: PREDICTED: similar to ral guanin... 96 2e-18
UniRef50_Q55AH0 Cluster: Ras guanine nucleotide exchange factor;... 96 2e-18
UniRef50_Q54H48 Cluster: Ras guanine nucleotide exchange factor;... 96 3e-18
UniRef50_Q8TEU7 Cluster: Rap guanine nucleotide exchange factor ... 95 5e-18
UniRef50_Q54GB4 Cluster: Ras guanine nucleotide exchange factor;... 95 6e-18
UniRef50_Q6FVQ6 Cluster: Candida glabrata strain CBS138 chromoso... 94 8e-18
UniRef50_UPI0000E1F333 Cluster: PREDICTED: RAS guanyl releasing ... 94 1e-17
UniRef50_Q8IV61 Cluster: RAS guanyl-releasing protein 3; n=79; E... 94 1e-17
UniRef50_O77086 Cluster: Guanine nucleotide-releasing factor 2; ... 94 1e-17
UniRef50_UPI000049A3AF Cluster: Ras guanine nucleotide exchange ... 93 1e-17
UniRef50_Q95WR8 Cluster: PXF isoform C; n=4; Caenorhabditis|Rep:... 93 1e-17
UniRef50_UPI0000499BEE Cluster: Ras guanine nucleotide exchange ... 91 6e-17
UniRef50_P14771 Cluster: Guanine nucleotide exchange factor SDC2... 91 6e-17
UniRef50_Q9NZL6 Cluster: Ral guanine nucleotide dissociation sti... 91 6e-17
UniRef50_UPI000069F86C Cluster: Ral guanine nucleotide dissociat... 91 7e-17
UniRef50_A7S390 Cluster: Predicted protein; n=2; Nematostella ve... 91 7e-17
UniRef50_Q5TND5 Cluster: ENSANGP00000025467; n=1; Anopheles gamb... 91 1e-16
UniRef50_Q179F5 Cluster: Guanine nucleotide exchange factor; n=2... 91 1e-16
UniRef50_O95398 Cluster: Rap guanine nucleotide exchange factor ... 91 1e-16
UniRef50_Q1DXK6 Cluster: Putative uncharacterized protein; n=1; ... 89 2e-16
UniRef50_Q4SCF7 Cluster: Chromosome 1 SCAF14655, whole genome sh... 89 3e-16
UniRef50_Q8WZA2 Cluster: Rap guanine nucleotide exchange factor ... 89 3e-16
UniRef50_Q2H8X6 Cluster: Putative uncharacterized protein; n=1; ... 88 5e-16
UniRef50_UPI00015B5B51 Cluster: PREDICTED: similar to ENSANGP000... 88 7e-16
UniRef50_UPI00006A087A Cluster: Ral guanine nucleotide dissociat... 88 7e-16
UniRef50_Q9N468 Cluster: Putative uncharacterized protein; n=3; ... 88 7e-16
UniRef50_Q8IZJ4 Cluster: Ral-GDS-related protein; n=32; Catarrhi... 88 7e-16
UniRef50_A7RH05 Cluster: Predicted protein; n=1; Nematostella ve... 87 1e-15
UniRef50_Q7K3Z6 Cluster: GH01501p; n=4; Diptera|Rep: GH01501p - ... 87 2e-15
UniRef50_Q17MY4 Cluster: Ral guanine nucleotide exchange factor,... 87 2e-15
UniRef50_Q16I23 Cluster: Guanine-nucleotide exchange factor c3g;... 86 3e-15
UniRef50_UPI0000DB6F3E Cluster: PREDICTED: similar to Gef26 CG94... 85 4e-15
UniRef50_Q4REE9 Cluster: Chromosome 10 SCAF15123, whole genome s... 85 4e-15
UniRef50_Q9UHV5 Cluster: Rap guanine nucleotide exchange factor-... 85 4e-15
UniRef50_Q8TDF6 Cluster: RAS guanyl-releasing protein 4; n=32; T... 85 4e-15
UniRef50_Q6BNH1 Cluster: Debaryomyces hansenii chromosome E of s... 85 4e-15
UniRef50_A2DHX3 Cluster: RasGEF domain containing protein; n=1; ... 85 5e-15
UniRef50_A2Q880 Cluster: Contig An01c0100, complete genome; n=10... 85 5e-15
UniRef50_Q92565 Cluster: Rap guanine nucleotide exchange factor ... 85 5e-15
UniRef50_Q4SD50 Cluster: Chromosome 1 SCAF14643, whole genome sh... 84 8e-15
UniRef50_Q9U4U5 Cluster: Ral guanine nucleotide exchange factor ... 84 8e-15
UniRef50_Q553C1 Cluster: Ras guanine nucleotide exchange factor;... 84 1e-14
UniRef50_A7SFW1 Cluster: Predicted protein; n=1; Nematostella ve... 83 1e-14
UniRef50_A2G2Z9 Cluster: RasGEF domain containing protein; n=1; ... 83 1e-14
UniRef50_UPI0000EC9E1A Cluster: Rap guanine nucleotide exchange ... 83 3e-14
UniRef50_UPI00015616C2 Cluster: PREDICTED: similar to ral guanin... 82 3e-14
UniRef50_UPI0000499502 Cluster: Ras guanine nucleotide exchange ... 82 3e-14
UniRef50_Q95V18 Cluster: Guanine nucleotide exchange factor; n=3... 82 5e-14
UniRef50_Q9UL65 Cluster: RAS guanyl-releasing protein 2; n=35; E... 82 5e-14
UniRef50_Q2GVZ4 Cluster: Putative uncharacterized protein; n=3; ... 81 6e-14
UniRef50_UPI00015616DC Cluster: PREDICTED: hypothetical protein,... 81 8e-14
UniRef50_UPI00015A741B Cluster: Hypothetical protein; n=3; Danio... 81 8e-14
UniRef50_Q6P112 Cluster: Ral guanine nucleotide dissociation sti... 81 8e-14
UniRef50_A4QNU6 Cluster: Zgc:162151 protein; n=6; Euteleostomi|R... 81 1e-13
UniRef50_UPI0000499955 Cluster: Ras guanine nucleotide exchange ... 80 1e-13
UniRef50_A7EYT6 Cluster: Putative uncharacterized protein; n=1; ... 80 1e-13
UniRef50_UPI00015A6BDA Cluster: UPI00015A6BDA related cluster; n... 79 3e-13
UniRef50_UPI00004D6636 Cluster: ral guanine nucleotide dissociat... 79 3e-13
UniRef50_Q6MBG2 Cluster: Putative uncharacterized protein; n=1; ... 79 4e-13
UniRef50_A6SRC2 Cluster: Putative uncharacterized protein; n=1; ... 78 6e-13
UniRef50_A2ETX5 Cluster: RasGEF domain containing protein; n=1; ... 78 7e-13
UniRef50_A2DMC1 Cluster: RasGEF domain containing protein; n=1; ... 78 7e-13
UniRef50_Q4RS43 Cluster: Chromosome 7 SCAF15001, whole genome sh... 77 1e-12
UniRef50_A5E0J4 Cluster: Putative uncharacterized protein; n=1; ... 77 2e-12
UniRef50_Q55EC7 Cluster: RasGEF domain-containing protein; n=1; ... 76 2e-12
UniRef50_A7TGT9 Cluster: Putative uncharacterized protein; n=1; ... 76 2e-12
UniRef50_O15211 Cluster: Ral guanine nucleotide dissociation sti... 76 2e-12
UniRef50_A7S271 Cluster: Predicted protein; n=1; Nematostella ve... 76 3e-12
UniRef50_A7RT22 Cluster: Predicted protein; n=1; Nematostella ve... 75 4e-12
UniRef50_Q6CUP1 Cluster: Similar to ca|CA0382|IPF16030 Candida a... 75 4e-12
UniRef50_UPI0000498500 Cluster: Ras guanine nucleotide exchange ... 75 5e-12
UniRef50_A7S619 Cluster: Predicted protein; n=2; Eumetazoa|Rep: ... 75 5e-12
UniRef50_Q0ULM6 Cluster: Putative uncharacterized protein; n=1; ... 75 7e-12
UniRef50_Q8IS17 Cluster: Nucleotide exchange factor RasGEF F; n=... 74 9e-12
UniRef50_A2DCA8 Cluster: RasGEF domain containing protein; n=1; ... 74 9e-12
UniRef50_Q8X027 Cluster: Related to aimless RasGEF; n=2; Neurosp... 74 9e-12
UniRef50_Q59Z59 Cluster: Putative uncharacterized protein LTE1; ... 74 9e-12
UniRef50_A6R1V9 Cluster: Putative uncharacterized protein; n=1; ... 74 9e-12
UniRef50_P34578 Cluster: Uncharacterized protein T20G5.5; n=2; C... 74 9e-12
UniRef50_A2F7D3 Cluster: RasGEF domain containing protein; n=1; ... 73 2e-11
UniRef50_A3LVY6 Cluster: GDP/GTP exchange factor; n=2; Saccharom... 73 2e-11
UniRef50_UPI00005A1264 Cluster: PREDICTED: similar to Ral guanin... 73 2e-11
UniRef50_Q752E6 Cluster: AFR630Cp; n=1; Eremothecium gossypii|Re... 73 3e-11
UniRef50_UPI0000E485ED Cluster: PREDICTED: similar to Ral guanin... 72 4e-11
UniRef50_UPI0000499FDF Cluster: Ras guanine nucleotide exchange ... 72 4e-11
UniRef50_Q4RPN7 Cluster: Chromosome 12 SCAF15007, whole genome s... 71 6e-11
UniRef50_A2F534 Cluster: RasGEF domain containing protein; n=1; ... 71 6e-11
UniRef50_UPI00015B4D6B Cluster: PREDICTED: similar to ral guanin... 71 8e-11
UniRef50_A2EE64 Cluster: RasGEF domain containing protein; n=2; ... 71 8e-11
UniRef50_UPI0000499915 Cluster: Ras guanine nucleotide exchange ... 71 1e-10
UniRef50_UPI0000498D55 Cluster: Ras guanine nucleotide exchange ... 71 1e-10
UniRef50_A4D140 Cluster: Rap guanine nucleotide exchange factor ... 71 1e-10
UniRef50_Q4P292 Cluster: Putative uncharacterized protein; n=1; ... 71 1e-10
UniRef50_UPI00005A5919 Cluster: PREDICTED: similar to Ral guanin... 70 1e-10
UniRef50_UPI000049A114 Cluster: Ras guanine nucleotide exchange ... 70 2e-10
UniRef50_Q2GV74 Cluster: Putative uncharacterized protein; n=1; ... 69 3e-10
UniRef50_UPI000049940E Cluster: Ras guanine nucleotide exchange ... 69 3e-10
UniRef50_UPI000065E24B Cluster: Rap guanine nucleotide exchange ... 69 3e-10
UniRef50_Q9DE48 Cluster: Ras-associated protein; n=11; Clupeocep... 69 3e-10
UniRef50_Q5KPL7 Cluster: Ras guanyl-nucleotide exchange factor, ... 69 3e-10
UniRef50_Q8SYL9 Cluster: RE54096p; n=4; Sophophora|Rep: RE54096p... 68 6e-10
UniRef50_A5DL36 Cluster: Putative uncharacterized protein; n=1; ... 68 6e-10
UniRef50_A4QP96 Cluster: Putative uncharacterized protein; n=4; ... 68 8e-10
UniRef50_A5DX26 Cluster: Putative uncharacterized protein; n=1; ... 67 1e-09
UniRef50_A4R2V9 Cluster: Putative uncharacterized protein; n=1; ... 67 1e-09
UniRef50_Q0TX72 Cluster: Putative uncharacterized protein; n=1; ... 67 1e-09
UniRef50_Q6C3H8 Cluster: Similar to CAGL0G06226g Candida glabrat... 66 2e-09
UniRef50_P07866 Cluster: Guanine nucleotide exchange factor LTE1... 66 2e-09
UniRef50_Q873I0 Cluster: Related to LTE1 protein; n=2; Neurospor... 65 4e-09
UniRef50_Q6UNM9 Cluster: LTE1-like protein; n=1; Epichloe festuc... 65 4e-09
UniRef50_Q19852 Cluster: Putative uncharacterized protein F28B4.... 65 6e-09
UniRef50_Q5T7U6 Cluster: Ral guanine nucleotide dissociation sti... 64 7e-09
UniRef50_A7F2T0 Cluster: Putative uncharacterized protein; n=1; ... 64 7e-09
UniRef50_A6RN08 Cluster: Putative uncharacterized protein; n=2; ... 64 1e-08
UniRef50_A7S186 Cluster: Predicted protein; n=1; Nematostella ve... 64 1e-08
UniRef50_A6R8M8 Cluster: Predicted protein; n=1; Ajellomyces cap... 64 1e-08
UniRef50_Q6CY10 Cluster: Guanine nucleotide exchange factor LTE1... 64 1e-08
UniRef50_Q6FT12 Cluster: Guanine nucleotide exchange factor LTE1... 64 1e-08
UniRef50_Q54F62 Cluster: RasGEF domain-containing protein; n=2; ... 63 2e-08
UniRef50_Q8N431 Cluster: Ras-GEF domain-containing family member... 63 2e-08
UniRef50_UPI00004996D1 Cluster: Ras guanine nucleotide exchange ... 62 4e-08
UniRef50_A7TSP6 Cluster: Putative uncharacterized protein; n=1; ... 62 4e-08
UniRef50_Q95S44 Cluster: GM09415p; n=4; Sophophora|Rep: GM09415p... 62 5e-08
UniRef50_Q1E205 Cluster: Putative uncharacterized protein; n=1; ... 62 5e-08
UniRef50_UPI000049A3F6 Cluster: Ras guanine nucleotide exchange ... 61 7e-08
UniRef50_A7SDN8 Cluster: Predicted protein; n=4; Eumetazoa|Rep: ... 61 7e-08
UniRef50_UPI000049A05E Cluster: Ras guanine nucleotide exchange ... 60 2e-07
UniRef50_Q4S5W0 Cluster: Chromosome 9 SCAF14729, whole genome sh... 60 2e-07
UniRef50_Q5B8N8 Cluster: Putative uncharacterized protein; n=1; ... 60 2e-07
UniRef50_UPI0000F20A79 Cluster: PREDICTED: hypothetical protein,... 59 3e-07
UniRef50_UPI000049982C Cluster: hypothetical protein 82.t00013; ... 59 3e-07
UniRef50_Q28EC1 Cluster: Ras-GEF domain-containing family member... 59 4e-07
UniRef50_Q54L90 Cluster: RasGEF domain-containing protein; n=1; ... 58 5e-07
UniRef50_Q2URQ9 Cluster: Ras1 guanine nucleotide exchange factor... 58 6e-07
UniRef50_A2QDU9 Cluster: Contig An02c0260, complete genome; n=4;... 58 8e-07
UniRef50_Q4SDT4 Cluster: Chromosome 1 SCAF14632, whole genome sh... 56 3e-06
UniRef50_Q75BH9 Cluster: Guanine nucleotide exchange factor LTE1... 55 6e-06
UniRef50_UPI000155BE40 Cluster: PREDICTED: similar to ras guanyl... 54 1e-05
UniRef50_Q9TVI2 Cluster: Putative uncharacterized protein plc-1;... 54 1e-05
UniRef50_P25300 Cluster: Bud site selection protein 5; n=4; Sacc... 54 1e-05
UniRef50_Q21758 Cluster: Putative uncharacterized protein; n=2; ... 53 2e-05
UniRef50_Q4S7S0 Cluster: Chromosome 18 SCAF14712, whole genome s... 52 3e-05
UniRef50_A2DTE7 Cluster: RasGEF domain containing protein; n=1; ... 52 3e-05
UniRef50_Q4P4A0 Cluster: Putative uncharacterized protein; n=1; ... 52 3e-05
UniRef50_UPI0000499745 Cluster: hypothetical protein 71.t00010; ... 51 7e-05
UniRef50_Q8N9B8 Cluster: Ras-GEF domain-containing family member... 51 7e-05
UniRef50_Q9P212 Cluster: 1-phosphatidylinositol-4,5-bisphosphate... 51 1e-04
UniRef50_Q76NI1 Cluster: Kinase non-catalytic C-lobe domain-cont... 50 1e-04
UniRef50_UPI00015617B8 Cluster: PREDICTED: similar to ral guanin... 49 3e-04
UniRef50_UPI00015616C9 Cluster: PREDICTED: similar to ral guanin... 49 3e-04
UniRef50_UPI000155FBAC Cluster: PREDICTED: similar to ral guanin... 49 4e-04
UniRef50_UPI000065E6FA Cluster: 1-phosphatidylinositol-4,5-bisph... 48 5e-04
UniRef50_UPI00015A537C Cluster: UPI00015A537C related cluster; n... 47 0.001
UniRef50_A2ELJ3 Cluster: RasGEF domain containing protein; n=1; ... 47 0.001
UniRef50_UPI00015B5A66 Cluster: PREDICTED: similar to phospholip... 47 0.002
UniRef50_UPI0001561431 Cluster: PREDICTED: similar to pleckstrin... 46 0.002
UniRef50_UPI000156180A Cluster: PREDICTED: similar to Ral guanin... 46 0.003
UniRef50_Q4RG56 Cluster: Chromosome 2 SCAF15106, whole genome sh... 46 0.003
UniRef50_Q8WUV7 Cluster: RALGPS1 protein; n=2; Homo sapiens|Rep:... 45 0.006
UniRef50_UPI000049A353 Cluster: hypothetical protein 66.t00031; ... 44 0.008
UniRef50_UPI0001561679 Cluster: PREDICTED: similar to ral guanin... 43 0.019
UniRef50_UPI00005A5D6B Cluster: PREDICTED: similar to Ral guanin... 43 0.019
UniRef50_UPI0000499966 Cluster: hypothetical protein 324.t00006;... 43 0.026
UniRef50_UPI000049964C Cluster: hypothetical protein 268.t00001;... 42 0.034
UniRef50_Q9HF75 Cluster: GTPase-activating protein BEM2; n=1; Er... 42 0.034
UniRef50_UPI0001561381 Cluster: PREDICTED: similar to guanine nu... 42 0.059
UniRef50_UPI000156180E Cluster: PREDICTED: similar to ral guanin... 41 0.078
UniRef50_UPI000049A0B9 Cluster: hypothetical protein 5.t00042; n... 41 0.078
UniRef50_UPI0001561664 Cluster: PREDICTED: similar to ral guanin... 41 0.10
UniRef50_UPI00006CFBA3 Cluster: hypothetical protein TTHERM_0048... 41 0.10
UniRef50_UPI0000E45D99 Cluster: PREDICTED: similar to Ral guanin... 40 0.14
UniRef50_UPI0000498AD4 Cluster: hypothetical protein 35.t00037; ... 40 0.14
UniRef50_Q22NC3 Cluster: Glutathione S-transferase, N-terminal d... 38 0.73
UniRef50_UPI000156177D Cluster: PREDICTED: similar to ral guanin... 37 1.3
UniRef50_Q4SBE9 Cluster: Chromosome 11 SCAF14674, whole genome s... 37 1.3
UniRef50_A7RZ47 Cluster: Predicted protein; n=1; Nematostella ve... 37 1.3
UniRef50_UPI0000499041 Cluster: Ras guanine nucleotide exchange ... 37 1.7
UniRef50_Q4PFF2 Cluster: Putative uncharacterized protein; n=1; ... 37 1.7
UniRef50_UPI0000F1E5D7 Cluster: PREDICTED: hypothetical protein;... 36 2.2
UniRef50_Q24CZ2 Cluster: Putative uncharacterized protein; n=1; ... 36 2.2
UniRef50_A0BHU9 Cluster: Chromosome undetermined scaffold_109, w... 36 2.9
UniRef50_UPI0000E47630 Cluster: PREDICTED: hypothetical protein,... 36 3.9
UniRef50_Q74EI2 Cluster: Putative uncharacterized protein; n=1; ... 35 5.1
UniRef50_Q7R248 Cluster: GLP_630_26283_22999; n=1; Giardia lambl... 35 5.1
UniRef50_Q234T9 Cluster: Putative uncharacterized protein; n=1; ... 35 5.1
UniRef50_A6SE29 Cluster: Putative uncharacterized protein; n=2; ... 35 5.1
UniRef50_Q9W1I2 Cluster: Benign gonial cell neoplasm protein; n=... 35 5.1
UniRef50_UPI00015B55F1 Cluster: PREDICTED: similar to GAPVD1 pro... 35 6.8
UniRef50_UPI00006CCFA2 Cluster: hypothetical protein TTHERM_0018... 35 6.8
UniRef50_A6TN10 Cluster: Two component transcriptional regulator... 35 6.8
UniRef50_A7TGB0 Cluster: Putative uncharacterized protein; n=1; ... 35 6.8
UniRef50_Q4SS73 Cluster: Chromosome 11 SCAF14479, whole genome s... 34 9.0
UniRef50_Q4RP06 Cluster: Chromosome 10 SCAF15009, whole genome s... 34 9.0
UniRef50_A6L0G0 Cluster: Putative TonB-dependent receptor; n=1; ... 34 9.0
UniRef50_Q7PY32 Cluster: ENSANGP00000008502; n=4; Culicidae|Rep:... 34 9.0
UniRef50_Q4CXE0 Cluster: Putative uncharacterized protein; n=2; ... 34 9.0
UniRef50_A2DPN7 Cluster: Putative uncharacterized protein; n=1; ... 34 9.0
UniRef50_Q13009 Cluster: T-lymphoma invasion and metastasis-indu... 34 9.0
>UniRef50_Q16MY3 Cluster: Ral guanine nucleotide exchange factor
with ph domain and sh3 binding motif, ralgps; n=1; Aedes
aegypti|Rep: Ral guanine nucleotide exchange factor with
ph domain and sh3 binding motif, ralgps - Aedes aegypti
(Yellowfever mosquito)
Length = 543
Score = 469 bits (1156), Expect = e-131
Identities = 256/541 (47%), Positives = 327/541 (60%), Gaps = 43/541 (7%)
Query: 78 KTNSLPAACSINQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNK 137
K+ SLP SI + D I+ S LR+SP+++ NQ+TLLD P F AI+P+EL +C W K NK
Sbjct: 4 KSQSLPPNASI-ANIDSIIISCLRVSPEELANQITLLDFPVFAAIQPDELASCAWNKKNK 62
Query: 138 LTVAPNVVAFTKRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAV 197
++PNVVAFTKRFN FWTVQE+LNG S K RAEI++HFIKVA+ LHELNNLHSLFA+
Sbjct: 63 AELSPNVVAFTKRFNHTIFWTVQEVLNGISAKERAEIISHFIKVARHLHELNNLHSLFAI 122
Query: 198 ISALHSASIYRLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYL-- 255
SAL SAS+YRL K+W +SKKDKQQF++LAE+F + +NW LREYL+S+ LPCIPYL
Sbjct: 123 TSALKSASVYRLEKSWVHVSKKDKQQFERLAEIFHDDNNWATLREYLESLKLPCIPYLGK 182
Query: 256 -------GIFLTDLVYIDIAHP----AGSPHRVTKMNIVLKALERYQSSEYE-IAPLPHV 303
G+FLTDLVYID+AHP R TKMN +L+ + YQ S+Y I P+P
Sbjct: 183 ENFHHDKGLFLTDLVYIDLAHPHKGGLEPEQRRTKMNNILRVISNYQGSDYSYIMPIPKT 242
Query: 304 ANFLNSVRYIEELQKFVEDDQYKLSLKLE--PPSPVGSCAGSKESVKETVLQGNVTTFNI 361
N+LNSVRYIEELQ EDDQYK SLKLE P SP S K S + TT N
Sbjct: 243 LNYLNSVRYIEELQNIFEDDQYKKSLKLEPLPSSPSSSALNGKNSSSKQTNSSIPTTDNG 302
Query: 362 SPSHKLGSGSLRLQGTSHQGKFIPT------------HRKCRSLGSNIFGK-SHTEDKMD 408
H SL L PT HRKCRSLG+NIF K S T +
Sbjct: 303 QHGHPSTLASLNLSPAKSSSMRFPTVTPNTSSAKFIGHRKCRSLGTNIFNKISCTTTQCS 362
Query: 409 EKTP------AGSVNLLDDTLLESPSSVACAKMSQSLPHSNITKPEDIQCD---FQGCVK 459
T S +LLDD++LE S S ++ D FQGC++
Sbjct: 363 SNTIHRTESFVKSRHLLDDSVLEDKVSADTTSTGSSDGVIGFESDAELAADILGFQGCLR 422
Query: 460 RKTILKEGRKISLSSWQRYWLQMSGNMLFFYGAKSFKGTNRSDFRSERCKVLTLVGWIAV 519
RKT++K R+ ++S+WQRYW+Q+ N L ++ KSFKGT R D++ E K+ TL GW
Sbjct: 423 RKTLMKHRRRPTVSAWQRYWVQIWANSLVYFAPKSFKGTERCDYKREPSKICTLEGWNVE 482
Query: 520 WADGDAADAFQLINHHSGTVYKFKAGSEYAAKQWIAKIEEVTNKIVKPLPA----NLMSF 575
D +D FQL+NH G +YKF+ GS W++ + +V ++ +P+ NLMSF
Sbjct: 483 TKDDAQSDTFQLVNHQHGHIYKFRTGSSDITLLWLSALNKVISQFAPDIPSKPPVNLMSF 542
Query: 576 E 576
E
Sbjct: 543 E 543
>UniRef50_UPI00015B534D Cluster: PREDICTED: similar to CG5522-PD;
n=1; Nasonia vitripennis|Rep: PREDICTED: similar to
CG5522-PD - Nasonia vitripennis
Length = 607
Score = 466 bits (1150), Expect = e-130
Identities = 248/501 (49%), Positives = 331/501 (66%), Gaps = 37/501 (7%)
Query: 78 KTNSLPAACSINQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNK 137
K+NSLP C+++ + A + +D+ +QLTLLD FK I+PEEL++C W K NK
Sbjct: 99 KSNSLPGRCNVSSPVPNATV-ATEIPAEDLASQLTLLDASVFKCIRPEELSSCSWNKKNK 157
Query: 138 LTVAPNVVAFTKRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAV 197
L VAPNVV+FT+RFN SFWTVQEILN +PK R+EI+AHFI+VAKKL++LNNLHSLFA+
Sbjct: 158 LLVAPNVVSFTRRFNHASFWTVQEILNAPTPKQRSEILAHFIRVAKKLYDLNNLHSLFAI 217
Query: 198 ISALHSASIYRLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGI 257
IS LHSASIYRL KTWACL+KKDK FDKLAE+F + NW LRE++ SI LPCIPYLG+
Sbjct: 218 ISGLHSASIYRLNKTWACLTKKDKSTFDKLAEVFSDKSNWMNLREHMDSIKLPCIPYLGL 277
Query: 258 FLTDLVYIDIAHPA---GSPH-RVTKMNIVLKALERYQSSEYE-IAPLPHVANFLNSVRY 312
FLTDLVYID+AHP G H R+ KMN VL + +Q+SEY I PLP V +L+SVRY
Sbjct: 278 FLTDLVYIDMAHPPTKNGDNHQRILKMNAVLTKVAMFQASEYPGIVPLPDVQRYLSSVRY 337
Query: 313 IEELQKFVEDDQYKLSLKLEPPSPVGSCAGSKESVKETVLQGNVTTFNISPSHKLGSGSL 372
IEELQKF+EDD +KLS+KLEP SP+ S + SKESV + V V ++SP+ +GSL
Sbjct: 338 IEELQKFLEDDHFKLSMKLEPNSPIPSSSSSKESVGDVVT--GVAALSLSPARGC-AGSL 394
Query: 373 RLQGTSHQGKFIPTHRKCRSLGSNIFGKSHTEDKMDEKTPAGSVNLLDDTLLE------- 425
RL S KF+P HRKCRSLG+NIFGK+ + + T +LLDD++LE
Sbjct: 395 RLHAASAANKFVPGHRKCRSLGTNIFGKAVVPLEANHVTVR---HLLDDSVLEEPHLATQ 451
Query: 426 -------SPSSVA------CAKMSQ----SLPHSNITKPEDIQCDFQGCVKRKTILKEGR 468
SP S A C+ +S+ S+ +I + +C QG ++RK +L++GR
Sbjct: 452 IVDLDQNSPGSPADAINDDCSLLSKTSTLSVLACDIDGSIEPRCIMQGSLRRKVVLRDGR 511
Query: 469 KISLSSWQRYWLQMSGNMLFFYGAKSFKGTNRSDFRSERCKVLTLVGWIAVWADGD-AAD 527
K ++++WQRYW+Q+ + + ++ K FKG +R DF+ E K+++++GWI D D
Sbjct: 512 KPAVTTWQRYWVQLWASSIVYFSPKCFKGNDRGDFKREPYKMVSILGWIVETLDNTFHGD 571
Query: 528 AFQLINHHSGTVYKFKAGSEY 548
F L + G + S Y
Sbjct: 572 TFLLADPKKGRGQNNERQSSY 592
>UniRef50_Q0E949 Cluster: CG5522-PA, isoform A; n=5;
Endopterygota|Rep: CG5522-PA, isoform A - Drosophila
melanogaster (Fruit fly)
Length = 702
Score = 438 bits (1080), Expect = e-121
Identities = 269/614 (43%), Positives = 351/614 (57%), Gaps = 86/614 (14%)
Query: 32 KINHKKQSTIPLNSQQSFTKDDCACYYNYGHGENGSNRQHDSIFHYKTNSLPAACSINQS 91
K +K S LNS S + D CYY + K+ SLPA SI Q
Sbjct: 106 KSTRRKNSIGCLNSFSS-SPDSPGCYYTIAASAAPPS---------KSQSLPAHASIKQL 155
Query: 92 WDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRF 151
D ++ SALR+ D + NQ+TLLD P F I+P+EL++C WTK +K PN+VAFTKRF
Sbjct: 156 -DAVILSALRVPADVLANQITLLDFPVFAQIQPDELSSCAWTKKDKHVNTPNIVAFTKRF 214
Query: 152 NRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTK 211
N SFWTVQEILN + PK RAEI+ HFIKVAKKLHELNNLHSLFA+ISA+ SASIYRLTK
Sbjct: 215 NHTSFWTVQEILNAEQPKQRAEIITHFIKVAKKLHELNNLHSLFAIISAMQSASIYRLTK 274
Query: 212 TWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPA 271
TWACLSKKD+ FD+L+++F + DNW LR YL+S+ LPCIPYLG+FLTDL+YID+AHP
Sbjct: 275 TWACLSKKDRNAFDRLSDIFSDQDNWANLRSYLESLRLPCIPYLGLFLTDLIYIDLAHPH 334
Query: 272 GS----PHRVTKMNIVLKALERYQSSEYE-IAPLPHVANFLNSVRYIEELQKFVEDDQYK 326
R KMN +L+ + YQ S Y+ + +L S+RYIEELQ E+DQYK
Sbjct: 335 KGGLEPEQRRNKMNNILRVISNYQQSNYKHLQKHEATQKYLTSIRYIEELQNIFEEDQYK 394
Query: 327 LSLKLEPPSPVG---SCAGSKESVKETVLQGNVTTFNISP-----SHKLGSGS------- 371
SL LEP SP G S SKES V+ + N+SP S ++ SG+
Sbjct: 395 RSLNLEPASPSGPSSSSCSSKESFNVEVVTPALGCLNLSPAKTIGSMRMASGTKFVPGHR 454
Query: 372 -LRLQGTSHQGKFIPTH--RKCR--------SLGS---------NIFGKSHTEDKMD--- 408
R GT + +P + KC+ +G+ IFGK T + D
Sbjct: 455 KCRSLGTKFRSSSLPRNFAEKCQCCIVMIAPGIGTISNKRCRCRRIFGKIATHNHSDGHP 514
Query: 409 -----EKTPAGSV---NLLDDTLLESPSSVACAKMSQSLPHSNITKPEDIQCDF------ 454
E P+ +LLDD++LE +++ A ++ ++ E I CDF
Sbjct: 515 HHLHLELDPSQVQPRHHLLDDSVLEHSDALSQADLT------SLESAEGIMCDFTGSDCD 568
Query: 455 ----------QGCVKRKTILKEGRKISLSSWQRYWLQMSGNMLFFYGAKSFKGTNRSDFR 504
GCV+RKT+ KEGRK +++SWQRYWLQ+ N L ++ KSFKG+ R+DF+
Sbjct: 569 LMSPEAAAAMHGCVRRKTVQKEGRKPAVASWQRYWLQIWANSLVYFPPKSFKGSERNDFK 628
Query: 505 SERCKVLTLVGWIAVWADGDA-ADAFQLINHHSGTVYKFKAGSEYAAKQWIAKI-EEVTN 562
E CKV L GW A +D + F+L + GTVY+F+ S W I + T
Sbjct: 629 REPCKVCPLDGWYAHVSDNTKHKNTFELCHRTLGTVYRFRTDSPQMTHLWSNAICKLATM 688
Query: 563 KIVKPLPANLMSFE 576
++ KPLP NLMSFE
Sbjct: 689 RVPKPLPTNLMSFE 702
>UniRef50_O15059 Cluster: Ral GEF with PH domain and SH3-binding
motif 1; n=80; Euteleostomi|Rep: Ral GEF with PH domain
and SH3-binding motif 1 - Homo sapiens (Human)
Length = 590
Score = 393 bits (968), Expect = e-108
Identities = 223/527 (42%), Positives = 320/527 (60%), Gaps = 44/527 (8%)
Query: 89 NQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFT 148
++S+D +V L+++P++ +Q+TL+D+P FKAI+PEEL +CGW+K K ++APNVVAFT
Sbjct: 69 SKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFT 128
Query: 149 KRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYR 208
+RFN+VSFW V+EIL Q+ K RAEI++HF+K+AKKL ELNNLHSL +V+SAL SA I+R
Sbjct: 129 RRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFR 188
Query: 209 LTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISL-PCIPYLGIFLTDLVYIDI 267
LTKTWA L++KDK F+KL L + DN+ REY++S+ + P IPYLGI+L DL+YID
Sbjct: 189 LTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDS 248
Query: 268 AHPAG-----SPHRVTKMNIVLKALERYQ-SSEYE-IAPLPHVANFLNSVRYIEELQKFV 320
A+PA + R +MN +L+ + Q S Y+ + LPHV +L SVRYIEELQKFV
Sbjct: 249 AYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFV 308
Query: 321 EDDQYKLSLKLEPPSPVGSCAGSKESVKETVLQGNVTTFNISPSHKLGSGSLRLQGTSHQ 380
EDD YKLSL++EP S SKE + F+ P+ S + L
Sbjct: 309 EDDNYKLSLRIEPGSSSPRLVSSKEDLAGPSAGSGSARFSRRPTCPDTSVAGSLPTPP-- 366
Query: 381 GKFIPTHRKCRSLGSNIF-------GKSHT-----------EDKMDEKTPAGSVNLLDDT 422
+P HRK SLG+N+ KS T + ++ ++P + L +
Sbjct: 367 ---VPRHRKSHSLGNNMMCQLSVVESKSATFPSEKARHLLDDSVLESRSPRRGLALTSSS 423
Query: 423 LLESPSSVACAKMSQSLPH--SNITKPED-IQCDF---------QGCVKRKTILKEGRKI 470
+ + S+ ++ S+ S + P C +G ++RKT+LKEGRK
Sbjct: 424 AVTNGLSLGSSESSEFSEEMSSGLESPTGPCICSLGNSAAVPTMEGPLRRKTLLKEGRKP 483
Query: 471 SLSSWQRYWLQMSGNMLFFYGAKSFKGTNRSDFRSERCKVLTLVGW-IAVWADGDAADAF 529
+LSSW RYW+ +SG+ L +YGAKS +GT+R ++S K +++VGW + + D + D F
Sbjct: 484 ALSSWTRYWVILSGSTLLYYGAKSLRGTDRKHYKSTPGKKVSIVGWMVQLPDDPEHPDIF 543
Query: 530 QLINHHSGTVYKFKAGSEYAAKQWIAKIEEVTNKIVKPLPANLMSFE 576
QL N G VYKF+ GS + A W +++ +PANLMSFE
Sbjct: 544 QLNNPDKGNVYKFQTGSRFHAILWHKHLDDACKSNRPQVPANLMSFE 590
>UniRef50_Q7Q955 Cluster: ENSANGP00000013079; n=1; Anopheles gambiae
str. PEST|Rep: ENSANGP00000013079 - Anopheles gambiae
str. PEST
Length = 564
Score = 334 bits (820), Expect = 5e-90
Identities = 175/326 (53%), Positives = 222/326 (68%), Gaps = 9/326 (2%)
Query: 78 KTNSLPAACSINQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNK 137
K+ SLP +I+ IV S ++SP ++ Q+TLLD P F AI+PEELT+CGWTK NK
Sbjct: 1 KSYSLPPNTTISDV-GSIVFSCQQVSPAELAAQITLLDFPIFNAIQPEELTSCGWTKKNK 59
Query: 138 LTVAPNVVAFTKRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAV 197
T+APNVVAFTKRFN +FWTVQEILNG SPK RAEI++HFIKVAKKLH++NNLHSLFAV
Sbjct: 60 HTLAPNVVAFTKRFNHTTFWTVQEILNGVSPKDRAEIISHFIKVAKKLHDINNLHSLFAV 119
Query: 198 ISALHSASIYRLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGI 257
ISAL SAS++RL ++W +S+KD+QQ D+L+ LF E+DNW++LR+ L LP IPYLGI
Sbjct: 120 ISALKSASVHRLKESWLLVSRKDQQQLDRLSHLFDESDNWSSLRKCLNQFKLPGIPYLGI 179
Query: 258 FLTDLVYIDIAHPAGSPH----RVTKMNIVLKALERYQSSEYE-IAPLPHVANFLNSVRY 312
FLTD++YID+ HP S R TKMN VL+ L YQSS Y I+P+P +L S RY
Sbjct: 180 FLTDIIYIDLMHPNKSGEESYARETKMNNVLRVLSSYQSSNYTFISPVPPTLRYLQSRRY 239
Query: 313 IEELQKFVEDDQYKLSLKLEPPSPVG--SCAGSKESVKETVLQG-NVTTFNISPSHKLGS 369
I+ELQ E+DQYK SL LEP + S G+ +S+ V + SP +
Sbjct: 240 IDELQNIFEEDQYKKSLNLEPTAGASTMSSGGTSDSIGRNVKTTIALAECKDSPDSTTCA 299
Query: 370 GSLRLQGTSHQGKFIPTHRKCRSLGS 395
+ S +FIP HRKC SLG+
Sbjct: 300 PNTSQTIVSSARQFIPGHRKCYSLGT 325
Score = 113 bits (273), Expect = 9e-24
Identities = 55/126 (43%), Positives = 84/126 (66%), Gaps = 4/126 (3%)
Query: 455 QGCVKRKTILKEGRKISLSSWQRYWLQMSGNMLFFYGAKSFKGTNRSDFRSERCKVLTLV 514
+G +KRKT+LK GRK +++SWQRYW+ + N + ++ K+FKG RS+F+ E K+ L
Sbjct: 439 EGYLKRKTVLKYGRKPTVASWQRYWVLIWSNTMIYFPPKTFKGNERSNFKKEPSKIFPLE 498
Query: 515 GWIAVWADGDAADA-FQLINHHSGTVYKFKAGSEYAAKQWIAKIEEVTN-KIVKPL--PA 570
GW A +D D FQL+N++ G Y+FK+GS +A +W+A +++VT K +PL
Sbjct: 499 GWTAEESDLPLQDEFFQLVNYNHGHAYRFKSGSNASANRWLAALKQVTTPKPAEPLSISL 558
Query: 571 NLMSFE 576
NL+SFE
Sbjct: 559 NLISFE 564
>UniRef50_A7SU64 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 603
Score = 322 bits (790), Expect = 2e-86
Identities = 175/421 (41%), Positives = 265/421 (62%), Gaps = 31/421 (7%)
Query: 90 QSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTK 149
+++D +V +++PD+ QLT +DL FK+I+PEE ++CGWTK NK +PNVVA TK
Sbjct: 51 KNYDAVVFDITKVTPDNFARQLTYMDLAVFKSIQPEEFSSCGWTKKNKSVQSPNVVALTK 110
Query: 150 RFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRL 209
RFN VSFW V+EILN + K R +M+HFI++AK+L+E+NNLHSL AVI+ L SA +YRL
Sbjct: 111 RFNHVSFWVVREILNAKKLKTRVAVMSHFIRIAKRLYEMNNLHSLKAVIAGLQSAPVYRL 170
Query: 210 TKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAH 269
+TW LS++D F+KL +L E N LR++L S LPCIP+LG++LTDL+YID H
Sbjct: 171 NQTWEQLSRRDHTIFEKLEDLLSEDQNRKRLRDHLNSTRLPCIPHLGMYLTDLMYIDTIH 230
Query: 270 P--AGSPH-RVTKMNIVLKALERYQSSEYE-IAPLPHVANFLNSVRYIEELQKFVEDDQY 325
P G + R KMN +++ + +Q S Y+ + PH+ +L+S+ YIEELQKF+ED+ Y
Sbjct: 231 PNTGGLDNERTRKMNDIIRIIAEFQQSHYDCLETQPHIQKYLDSMNYIEELQKFLEDNNY 290
Query: 326 KLSLKLEPPSPVGSCAGSKESVKETVLQGNVTTFNISPSHKLGSGSLRLQGTSHQGKFIP 385
+LSL++EP S V S + V + + +++T+ +SP TS KF+P
Sbjct: 291 RLSLQIEPKS-VKSSGEATSGVNLSRSRESLSTYPVSPK----------ASTSQVSKFVP 339
Query: 386 THRKCRSLGSNIFGK--SHTEDKMDEKTPA---GSVNLLDDTLLESPSS---VACAKMSQ 437
HRK SLG+N+ + + D + + A GS NLLDD++L+ S V
Sbjct: 340 GHRKAYSLGTNVLQTVGAPSLDSLSIASIASSTGSRNLLDDSILDDQGSGILVNGRDSEL 399
Query: 438 SLPH-SNITKPEDI-----QCDF--QGCVKRKTILKEGRKISLSSWQRYWLQMSGNMLFF 489
SL S + + E+ Q +F +G +KRK L+ G+K+++S WQ++W+ ++G L++
Sbjct: 400 SLEKGSGMYESEESNLFMHQSEFLVEGFLKRKKCLRNGKKLAVSYWQKFWVGLNGAYLYY 459
Query: 490 Y 490
+
Sbjct: 460 F 460
Score = 56.0 bits (129), Expect = 3e-06
Identities = 29/75 (38%), Positives = 39/75 (52%), Gaps = 1/75 (1%)
Query: 503 FRSERCKVLTLVGWIAVW-ADGDAADAFQLINHHSGTVYKFKAGSEYAAKQWIAKIEEVT 561
F+SE KV+ + GW V +D D FQL + +G YKFK GS+ W + + T
Sbjct: 521 FKSEAQKVVCIQGWTVVMQSDARHPDCFQLTDDVNGNSYKFKCGSQSVVLMWYTYLSQAT 580
Query: 562 NKIVKPLPANLMSFE 576
N P NL+SFE
Sbjct: 581 NLKKNQPPPNLISFE 595
>UniRef50_Q4T1D4 Cluster: Chromosome undetermined SCAF10661, whole
genome shotgun sequence; n=2; Tetraodontidae|Rep:
Chromosome undetermined SCAF10661, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 564
Score = 287 bits (703), Expect = 7e-76
Identities = 197/550 (35%), Positives = 297/550 (54%), Gaps = 76/550 (13%)
Query: 80 NSLPAACS-INQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKL 138
+SL +C+ +S+D +V L+++P++ +Q+TL+D P FKAI+PEEL +CGW + K
Sbjct: 5 DSLDVSCAEYAKSYDAVVFDVLKVTPEEFASQITLMDAPVFKAIQPEELASCGWNRKEKH 64
Query: 139 TVAPNVVAFTKRFNRVSFWTVQ------------EILNG--QSPKARA------------ 172
++APNVVAFT RFN+VSFW V+ EIL+ + K R
Sbjct: 65 SLAPNVVAFTCRFNQVSFWLVREILTAQKLKTRAEILSHFVKIAKVRPRRERIHTGVGRG 124
Query: 173 -EIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFDKLAELF 231
E+ + + +KL ELNNLH+L +V+SAL SA I+RL+KTW+ +S+KDK F+KL L
Sbjct: 125 EEVTSGCVVCWQKLLELNNLHALVSVLSALQSAPIFRLSKTWSLISRKDKATFEKLNYLT 184
Query: 232 GETDNWTALREYLKSISL-PCIPYLGIFLTDLVYIDIAHPAG-----SPHRVTKMNIVLK 285
+ +N+T +REY++S+ + PCIPYLGI+L D++YID A+PA + R +MN +L+
Sbjct: 185 SKEENYTRMREYMRSLKMEPCIPYLGIYLLDMIYIDSAYPASDSIMETEQRSNQMNNLLR 244
Query: 286 AL-ERYQSSEYE-IAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEPPSPVGSCAGS 343
+ ++ S Y+ + LPHV +L+SV YIEELQKFVEDD +KLSLK+EP
Sbjct: 245 VMSDQQMSCNYDHLVTLPHVQKYLSSVHYIEELQKFVEDDNFKLSLKIEPGDGSPRLTSY 304
Query: 344 KESVKETVLQGNVTTFNISPSHKLGSGSLRLQGTSHQGKFIPTHRKCRSLG-SNIFGKSH 402
K+ + + P+ S+R+Q + HRK S+G S +F
Sbjct: 305 KKELAGVSEAPVLVRSGRRPT--CPDASIRVQIPTLPPSH---HRKSHSVGNSMMFHAGM 359
Query: 403 TEDKMDEKTPAGSVNLLDDTLLESPSSVACAKMSQSLPHSNITKPEDIQ----------- 451
+E + + +LLDD+ LES S V A+ + P S ++
Sbjct: 360 SESRSATFSREKPRHLLDDSFLESQSPVR-AEPQAAFPSSGLSLGAACTQRWAPTGRFPI 418
Query: 452 CDFQGCVKRKTILKEGRKISLSSWQRYWLQMSGNMLFFYGAKSFKGTNRSDFRSERCKVL 511
G T + +LSSW R+W+ +SG+ L FYGAK+ + + R ++S CK +
Sbjct: 419 TTHPGATSTPTGAPQTPAAALSSWTRFWISLSGSTLTFYGAKALRASERKHYKSSPCKKV 478
Query: 512 TLVGWIAVWADGDA-ADAFQLIN----------H-------HS----GTVYKFKAGSEYA 549
+ GW+ + D + + FQL N H HS G VYKF+ GS ++
Sbjct: 479 CVTGWMVLLPDDPSRLNIFQLSNPDKGRTRCLRHLCSTPPTHSSAPAGDVYKFQTGSRFS 538
Query: 550 AKQWIAKIEE 559
A W K+EE
Sbjct: 539 AIIWHKKLEE 548
>UniRef50_Q5RH52 Cluster: Novel RasGEF domain containing protein;
n=6; Euteleostomi|Rep: Novel RasGEF domain containing
protein - Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 564
Score = 195 bits (476), Expect = 2e-48
Identities = 136/349 (38%), Positives = 198/349 (56%), Gaps = 45/349 (12%)
Query: 90 QSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTK 149
+S+D +V L+++P++ Q+TL+D P F+AI+PEEL++CGW K K + APN VAFT+
Sbjct: 44 KSFDAVVFDVLKVTPEEYAGQITLMDAPVFRAIQPEELSSCGWNKKEKHSSAPNAVAFTR 103
Query: 150 RFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRL 209
RFN Q++ + S A +MA + A + + L +A++S A+ RL
Sbjct: 104 RFN-------QKLCDMNSLHA---VMA--VVSALQSAPIFRLTKTWALLSRKDKATFERL 151
Query: 210 TKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISL-PCIPYLGIFLTDLVYIDIA 268
L + DN+ LR+Y+ S S+ CIPYLGI+L+DL YID A
Sbjct: 152 ------------------EYLMSKEDNYKRLRDYISSQSMTSCIPYLGIYLSDLTYIDSA 193
Query: 269 HPA-GS----PHRVTKMNIVLKALERYQ-SSEYEIAPLPHVANFLNSVRYIEELQKFVED 322
+P+ GS R MN +L+ + Q S EYEI LPHV +LNSVRYIEELQKFVED
Sbjct: 194 YPSTGSILENEQRSNLMNNILRIISDLQRSCEYEIPVLPHVQKYLNSVRYIEELQKFVED 253
Query: 323 DQYKLSLKLEPPSPVGSCAGSKESVKETVLQGNVTTFNISPSH-KLGSGSL-RLQGTSHQ 380
D YKLSLK+EPP+ + + +E + +++ + H + G+L ++ T
Sbjct: 254 DNYKLSLKIEPPA---TSTPRTTASREDLTGPDISASPLCGRHGNVAEGALPKVPPTPPS 310
Query: 381 GKFIPT--HRKCRSLGSNIFGKSHTEDKMDEKTP-AGSVNLLDDTLLES 426
+ + T HRKC SLG N K++T + P AGS +LLDD++LES
Sbjct: 311 PRNLITYGHRKCHSLGYNFIHKTNTVEFKSATFPNAGSRHLLDDSVLES 359
Score = 103 bits (248), Expect = 1e-20
Identities = 48/123 (39%), Positives = 74/123 (60%), Gaps = 1/123 (0%)
Query: 455 QGCVKRKTILKEGRKISLSSWQRYWLQMSGNMLFFYGAKSFKGTNRSDFRSERCKVLTLV 514
QG ++RKT+LKEG+K ++++W +YW+ + G L++Y AKS K T R F+S K + ++
Sbjct: 442 QGVLRRKTVLKEGKKPTVAAWTKYWVALCGTQLYYYTAKSLKATERKHFKSTASKTVCVL 501
Query: 515 GWIAVWADG-DAADAFQLINHHSGTVYKFKAGSEYAAKQWIAKIEEVTNKIVKPLPANLM 573
G +A+ AD + D F L + G YKF+AG+ A W + + +PANLM
Sbjct: 502 GLMAMMADDPEHPDVFLLTDSEHGNSYKFQAGNRMNALLWFKHLSAACQSNRQQVPANLM 561
Query: 574 SFE 576
SFE
Sbjct: 562 SFE 564
>UniRef50_UPI0000E478B1 Cluster: PREDICTED: similar to RALGPS1
protein, partial; n=1; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to RALGPS1 protein,
partial - Strongylocentrotus purpuratus
Length = 277
Score = 188 bits (459), Expect = 3e-46
Identities = 92/182 (50%), Positives = 128/182 (70%), Gaps = 5/182 (2%)
Query: 90 QSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTK 149
+S+D V LR+ P++ Q+TLLD+P FKAI EEL++C W+ +K T+ PN+VAF+K
Sbjct: 84 KSYDRAVFDMLRVQPEEFATQITLLDIPAFKAITSEELSSCAWSGKSKNTLCPNIVAFSK 143
Query: 150 RFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRL 209
RFN+VSFW V E+L Q KARAE++ HFIKVAKKL ++NNLH+ A+ISALHSASI+RL
Sbjct: 144 RFNQVSFWVVHEVLITQMTKARAEVIGHFIKVAKKLFDINNLHATMAIISALHSASIFRL 203
Query: 210 TKTWACLSKKDKQQFDKLAELFGETDNWT----ALREYLKS-ISLPCIPYLGIFLTDLVY 264
TKTW + KK++ +KL+EL E DN A+ E+ +S L +PY+ +L + Y
Sbjct: 204 TKTWNLVHKKERATCEKLSELMTEDDNMNNILRAISEFQQSQYDLENLPYVQKYLLSVRY 263
Query: 265 ID 266
I+
Sbjct: 264 IE 265
Score = 63.7 bits (148), Expect = 1e-08
Identities = 27/47 (57%), Positives = 37/47 (78%)
Query: 280 MNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYK 326
MN +L+A+ +Q S+Y++ LP+V +L SVRYIEELQKFVE+D YK
Sbjct: 231 MNNILRAISEFQQSQYDLENLPYVQKYLLSVRYIEELQKFVEEDNYK 277
>UniRef50_Q5C2U2 Cluster: SJCHGC07188 protein; n=1; Schistosoma
japonicum|Rep: SJCHGC07188 protein - Schistosoma
japonicum (Blood fluke)
Length = 191
Score = 155 bits (376), Expect = 3e-36
Identities = 72/160 (45%), Positives = 106/160 (66%)
Query: 101 RLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQ 160
+++P+D Q+TL++L FKAI+ EE + W K APN+VA T+ FN+++FW +
Sbjct: 32 KVTPEDFAKQITLIELSFFKAIRREEFASLKWNGREKHLYAPNIVASTRWFNQINFWVQK 91
Query: 161 EILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKD 220
EIL R E+++ FIK++KKL E+NNL+S ++ISAL IYRL TW+ L KD
Sbjct: 92 EILKYSCVSKRTEMLSFFIKISKKLVEINNLYSAMSIISALQVECIYRLRHTWSGLGNKD 151
Query: 221 KQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLT 260
+ + +L ELF + DN RE++ SISLP IPYLG++L+
Sbjct: 152 RAAYRRLEELFSQDDNCRRQREHMNSISLPGIPYLGLYLS 191
>UniRef50_Q5B8H1 Cluster: Putative uncharacterized protein; n=1;
Emericella nidulans|Rep: Putative uncharacterized
protein - Emericella nidulans (Aspergillus nidulans)
Length = 468
Score = 140 bits (338), Expect = 1e-31
Identities = 76/242 (31%), Positives = 129/242 (53%), Gaps = 13/242 (5%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTV 159
L++ ++ QLTL++ F ++P EL W + VAPNV A + FN++S W
Sbjct: 201 LKIDAREIARQLTLMESCIFGKVQPNELMHKNWQRRESQDVAPNVRALIQFFNQLSGWVG 260
Query: 160 QEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKK 219
+L K R +++ HFI VA H+L N ++ +++S L SA +YRL +TWA ++++
Sbjct: 261 ALVLAESDLKPRTQVIGHFINVANACHDLQNYSAVVSILSGLQSAPVYRLGRTWAMVTQR 320
Query: 220 DKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSP----- 274
D + + L + N R L+ PCIP+LGIFL DLV+I+ +P +P
Sbjct: 321 DCDKLEPLQAMMSSEQNHQTYRNILRRAIPPCIPFLGIFLKDLVFIEDGNPELTPDERLI 380
Query: 275 --HRVTKMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQ-YKLSLKL 331
R + M + ++ +Q + Y + P+P + +L + ELQ+ V ++ + S +L
Sbjct: 381 NFSRYSMMASTIDTVQHFQEAMYCLQPVPELQEYLAT-----ELQRAVNSERLWDRSCEL 435
Query: 332 EP 333
EP
Sbjct: 436 EP 437
>UniRef50_Q9GQC2 Cluster: Ras guanine nucleotide exchange factor
RasGEFB; n=3; Dictyostelium discoideum|Rep: Ras guanine
nucleotide exchange factor RasGEFB - Dictyostelium
discoideum (Slime mold)
Length = 1529
Score = 139 bits (336), Expect = 2e-31
Identities = 81/237 (34%), Positives = 128/237 (54%), Gaps = 8/237 (3%)
Query: 103 SPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEI 162
S D+ QLTLLD +K+I+ EL W+K ++ T PN+ + RFN S + I
Sbjct: 1282 SSTDIAEQLTLLDFDSYKSIEEIELLNQAWSKPDQKTNTPNIASMVNRFNSFSSFVSWAI 1341
Query: 163 LNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQ 222
L K R+++M IK+ L++L+N + L A +S L ++ +YRL T + +SK+ ++
Sbjct: 1342 LRENDIKQRSKMMLKMIKICYALYKLSNFNGLLAGLSGLMASGVYRLNHTKSLISKQYQK 1401
Query: 223 QFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYI------DIAHPAGSPHR 276
+FD L + + R+ + S P IPYLGI+LTDL +I +I R
Sbjct: 1402 KFDFLCKFLDTKKSHKVYRDIIHSTCPPLIPYLGIYLTDLTFIEDGNQDEIKGLINFKKR 1461
Query: 277 VTKMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEP 333
N +L+ +++YQ Y I P P V FL + ++ + +KF EDD Y+ S+ LEP
Sbjct: 1462 EMIFNTILE-IQQYQQQGYTIKPKPSVLGFLCELPHMSDKKKF-EDDTYEQSILLEP 1516
>UniRef50_P28818 Cluster: Guanine nucleotide-releasing protein; n=24;
Euteleostomi|Rep: Guanine nucleotide-releasing protein -
Rattus norvegicus (Rat)
Length = 1244
Score = 138 bits (335), Expect = 3e-31
Identities = 80/239 (33%), Positives = 133/239 (55%), Gaps = 15/239 (6%)
Query: 106 DVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNG 165
++ QLTLLD FK+I EE GW K +K P ++ T+ FN +S EIL
Sbjct: 1012 EIAEQLTLLDHLVFKSIPYEEFFGQGWMKADKNERTPYIMKTTRHFNHISNLIASEILRN 1071
Query: 166 QSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFD 225
+ ARA + ++ VA L+N +++ + S+++ ++I+RL KTW +SK+ K FD
Sbjct: 1072 EEVSARASTIEKWVAVADICRCLHNYNAVLEITSSINRSAIFRLKKTWLKVSKQTKSLFD 1131
Query: 226 KLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPH---RVTKMNI 282
KL +L + LRE L++ PC+PYLG++LTDL +++ P + +KM +
Sbjct: 1132 KLQKLVSSDGRFKNLRETLRNCDPPCVPYLGMYLTDLAFLEEGTPNYTEDGLVNFSKMRM 1191
Query: 283 ---VLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQ--YKLSLKLEPPSP 336
+++ + ++Q + Y+I P P V +L ++E FV DD+ Y+ SL++EP P
Sbjct: 1192 ISHIIREIRQFQQTTYKIEPQPKVTQYL-----VDE--TFVLDDESLYEASLRIEPKLP 1243
>UniRef50_O14827 Cluster: Ras protein-specific guanine
nucleotide-releasing factor 2; n=28; cellular
organisms|Rep: Ras protein-specific guanine
nucleotide-releasing factor 2 - Homo sapiens (Human)
Length = 1237
Score = 133 bits (322), Expect = 1e-29
Identities = 81/241 (33%), Positives = 130/241 (53%), Gaps = 11/241 (4%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQE 161
LS ++ Q+TLLD F++I EE GW KL+K P ++ ++ FN +S +
Sbjct: 1001 LSAMELAEQITLLDHVIFRSIPYEEFLGQGWMKLDKNERTPYIMKTSQHFNDMSNLVASQ 1060
Query: 162 ILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDK 221
I+N +RA + ++ VA L+N + + + SAL+ ++IYRL KTWA +SK+ K
Sbjct: 1061 IMNYADVSSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTK 1120
Query: 222 QQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPH---RVT 278
DKL + + LRE LK+ + P +PYLG++LTDL +I+ P + +
Sbjct: 1121 ALMDKLQKTVSSEGRFKNLRETLKNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGLVNFS 1180
Query: 279 KMNI---VLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEPPS 335
KM + +++ + ++Q + Y I P VA +L I + ED Y+LSLK+EP
Sbjct: 1181 KMRMISHIIREIRQFQQTSYRIDHQPKVAQYLLDKDLIID-----EDTLYELSLKIEPRL 1235
Query: 336 P 336
P
Sbjct: 1236 P 1236
>UniRef50_UPI00015B5B5D Cluster: PREDICTED: similar to conserved
hypothetical protein; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to conserved hypothetical protein -
Nasonia vitripennis
Length = 1557
Score = 132 bits (318), Expect = 3e-29
Identities = 78/238 (32%), Positives = 125/238 (52%), Gaps = 11/238 (4%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQE 161
LS ++ Q+T LD F +I EE W K +K T AP++ TKRFN VS V E
Sbjct: 1300 LSALEIAEQMTYLDHQIFISIASEEFLGQAWMKTDKATRAPHITLMTKRFNEVSQLVVSE 1359
Query: 162 ILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDK 221
I+ + +AR + + VA L+N + + + +A ++S+YRL KTW +SK K
Sbjct: 1360 IIRRSNMQARVGAIEKWAAVADISRVLHNYNGVLQICAAFTNSSVYRLKKTWEKVSKTTK 1419
Query: 222 QQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPH---RVT 278
Q ++L + + LR+ L PCIPYLG++LTDL +I+ P + +
Sbjct: 1420 QTIERLQNIVSSEHRFRNLRDALHRCDPPCIPYLGLYLTDLSFIEEGTPNFTDDGLLNFS 1479
Query: 279 KMNI---VLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEP 333
KM + V++ + +Q + Y+I + V N+L + E E+D Y++SL++EP
Sbjct: 1480 KMRMIAHVIREIRHFQQTPYKIELITKVTNYLLDSSLLLE-----EEDLYRMSLEIEP 1532
>UniRef50_P26674 Cluster: Protein ste6; n=1; Schizosaccharomyces
pombe|Rep: Protein ste6 - Schizosaccharomyces pombe
(Fission yeast)
Length = 911
Score = 130 bits (315), Expect = 7e-29
Identities = 81/255 (31%), Positives = 132/255 (51%), Gaps = 13/255 (5%)
Query: 87 SINQSWDDIVCS---ALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPN 143
S++ S D I+ L L P ++ QL +L+ F I + T W LN+ +
Sbjct: 644 SLHNSPDPIIYKDELVLLLPPREIAKQLCILEFQSFSHISRIQFLTKIWDNLNRFSPKEK 703
Query: 144 VVAFTKRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHS 203
F + V+F T + I+ + P+ R ++A+FI+V L ELNN SLF++ISAL+S
Sbjct: 704 TSTFYLSNHLVNFVT-ETIVQEEEPRRRTNVLAYFIQVCDYLRELNNFASLFSIISALNS 762
Query: 204 ASIYRLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLV 263
+ I+RL KTWA L+ K F+ L L N++ R+ L++ LPC+P+LG++ TDL
Sbjct: 763 SPIHRLRKTWANLNSKTLASFELLNNLTEARKNFSNYRDCLENCVLPCVPFLGVYFTDLT 822
Query: 264 YIDIAHPAGSPHRV-----TKMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQK 318
++ + + + TK+ +L ++++QS Y P+ V LN V E
Sbjct: 823 FLKTGNKDNFQNMINFDKRTKVTRILNEIKKFQSVGYMFNPINEVQELLNEVISRERNTN 882
Query: 319 FVEDDQYKLSLKLEP 333
+ Y+ SL +EP
Sbjct: 883 NI----YQRSLTVEP 893
>UniRef50_Q54XL4 Cluster: Putative uncharacterized protein; n=1;
Dictyostelium discoideum AX4|Rep: Putative
uncharacterized protein - Dictyostelium discoideum AX4
Length = 2050
Score = 130 bits (314), Expect = 1e-28
Identities = 70/207 (33%), Positives = 112/207 (54%), Gaps = 4/207 (1%)
Query: 59 NYGHGENGSNRQHDSIFHYKTNSLPAACSINQSWDDIVCSALRLSPDDVGNQLTLLDLPC 118
N + N +N +++ F +T P + + + S DI S + ++ LT +D
Sbjct: 1152 NNNNNNNNNNNNNNNTFWVQTR--PRSSTWSSS--DIFLSIMDAPAKEIAKSLTAIDFSI 1207
Query: 119 FKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNGQSPKARAEIMAHF 178
F I+ +EL W K + APN++ RFN +S +Q ILN + K R ++MA F
Sbjct: 1208 FICIETQELMNGAWGKPHLKDKAPNIIKLINRFNEISMNVIQTILNEEKLKDRCKVMARF 1267
Query: 179 IKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFDKLAELFGETDNWT 238
IK+AK LHEL+N +SL A+ + + +SI RL T L K ++ L +L +N+
Sbjct: 1268 IKIAKNLHELHNYNSLMAIYAGISHSSITRLKWTKKILPKTHQKTLSDLEKLMESDENFK 1327
Query: 239 ALREYLKSISLPCIPYLGIFLTDLVYI 265
R LK+I+ PCIP+LG+ L+D+ +I
Sbjct: 1328 NYRNELKTITTPCIPFLGLILSDMTFI 1354
>UniRef50_Q23867 Cluster: Aimless RasGEF; n=3; Dictyostelium
discoideum|Rep: Aimless RasGEF - Dictyostelium
discoideum (Slime mold)
Length = 605
Score = 129 bits (312), Expect = 2e-28
Identities = 80/247 (32%), Positives = 127/247 (51%), Gaps = 17/247 (6%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQE 161
+ +++ QLTL++ ++ IKP EL W K + APNV+ RFN VS W
Sbjct: 352 IDEEEIARQLTLIEFEIYRNIKPPELLNQSWNKTKLKSRAPNVLKMIDRFNSVSMWVATM 411
Query: 162 ILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDK 221
I+ KARA +M FIK+A L LNN +SL A+I+ L+ +S+YRL T LS +
Sbjct: 412 IIQTTKVKARARMMTRFIKIADHLKNLNNYNSLMAIIAGLNFSSVYRLKYTREELSAQTM 471
Query: 222 QQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYID------IAHPAG--- 272
+ + L ++ ++ R L+++ P +PYLG+ LTDL +ID + G
Sbjct: 472 RTYSDLEKIMNSEGSFKTYRTRLQNVP-PMLPYLGVHLTDLTFIDENPNNFVTDVGGKQV 530
Query: 273 SPHRVTKMNIVLKALERYQSSE---YEIAPLPHVANFLNSVR---YIEELQKFVEDDQYK 326
S TK +V K + Q ++ Y + P+ + FL ++R L ++ + + Y+
Sbjct: 531 SLINFTKRTLVFKIISLIQETQVVPYNLQPVHQIQEFLLNIRSDLKAHTLDQY-QQELYR 589
Query: 327 LSLKLEP 333
SLK EP
Sbjct: 590 ESLKREP 596
>UniRef50_Q13972 Cluster: Guanine nucleotide-releasing protein; n=24;
Euteleostomi|Rep: Guanine nucleotide-releasing protein -
Homo sapiens (Human)
Length = 1275
Score = 129 bits (312), Expect = 2e-28
Identities = 75/237 (31%), Positives = 125/237 (52%), Gaps = 11/237 (4%)
Query: 106 DVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNG 165
++ QLTLLD FK I EE GW KL K P ++ TK FN +S EI+
Sbjct: 1043 EIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEIIRN 1102
Query: 166 QSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFD 225
+ AR + ++ VA L+N +++ + S+++ ++I+RL KTW +SK+ K D
Sbjct: 1103 EDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALID 1162
Query: 226 KLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPH---RVTKMNI 282
KL +L + LRE LK+ PC+PYLG++LTDL +I+ P + +KM +
Sbjct: 1163 KLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMRM 1222
Query: 283 ---VLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEPPSP 336
+++ + ++Q + Y+I V +L ++ + E+ Y+ SL++EP P
Sbjct: 1223 ISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMD-----EESLYESSLRIEPKLP 1274
>UniRef50_Q555T3 Cluster: Ras guanine nucleotide exchange factor;
n=2; Dictyostelium discoideum|Rep: Ras guanine
nucleotide exchange factor - Dictyostelium discoideum
AX4
Length = 929
Score = 128 bits (309), Expect = 4e-28
Identities = 72/244 (29%), Positives = 123/244 (50%), Gaps = 8/244 (3%)
Query: 98 SALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWT-KLNKLTVAPNVVAFTKRFNRVSF 156
S + SP D+ QLTL++ F+++K +EL WT +K +PN+++ N+++
Sbjct: 671 SFMDYSPQDIAKQLTLIEFKLFQSVKMKELYHKSWTISKSKFENSPNIMSLITMSNKIAN 730
Query: 157 WTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACL 216
W E++ PK R E++ FI VA+ ++NN ++L VIS L ++++ RL +TW L
Sbjct: 731 WVATEVVTTPHPKKRVEVLKRFISVAEHCKKINNFNTLMEVISGLSNSAVSRLKETWKSL 790
Query: 217 SKKDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPH- 275
+ F+ L +NW + R+ LK+ PC+PYLG+FL D+ +I+ + S
Sbjct: 791 PTRYVNSFNSLQNFLKTDENWKSYRQTLKTKETPCLPYLGLFLQDINFIEDGNSNLSSEN 850
Query: 276 ---RVTKMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIE-ELQKFVEDDQYKLSLKL 331
KMN++ Q ++ P + N Y E ++ E + Y S +
Sbjct: 851 DWVNFKKMNLLTSVFTEIQ--YFQRHPYFSFSTHQNIQTYFEKDIVILPEKELYAFSKFI 908
Query: 332 EPPS 335
E PS
Sbjct: 909 ESPS 912
>UniRef50_Q54H67 Cluster: Ras guanine nucleotide exchange factor; n=2;
Dictyostelium discoideum|Rep: Ras guanine nucleotide
exchange factor - Dictyostelium discoideum AX4
Length = 1298
Score = 128 bits (309), Expect = 4e-28
Identities = 69/240 (28%), Positives = 123/240 (51%), Gaps = 12/240 (5%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTV 159
L + P ++ QLTL+D FK + P + W+K + PN++ F R N VS+W
Sbjct: 961 LDIHPVEIARQLTLIDYELFKKLSPTDFYHTAWSKPDAKEKVPNLINFINRSNTVSYWVA 1020
Query: 160 QEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKK 219
EIL+ + K R ++ FI +A+ L + +N ++L ++ L+ SI RL KTW + KK
Sbjct: 1021 TEILSSSNIKHRVSVLKRFITIAEILRKFHNWNTLTGILMGLNLGSIQRLKKTWESIDKK 1080
Query: 220 DKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYID-----IAHPAGSP 274
L L E N++ R+ + + + PC+P++ ++L DL +I+ + + +
Sbjct: 1081 QLDSLQNLINLTSERLNYSNYRKEMSTPTYPCLPFMAVYLKDLYFIEENPDYLENGYINF 1140
Query: 275 HRVTKMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEPP 334
++ ++ VL ++RYQ+ +Y + + + N L SV + D YK S +E P
Sbjct: 1141 EKMKMISKVLIEIKRYQTEQYWLKKIDAIENILKSV-------VLTDKDLYKASHMIEQP 1193
>UniRef50_Q552M5 Cluster: RasGEF domain-containing protein; n=2;
Dictyostelium discoideum|Rep: RasGEF domain-containing
protein - Dictyostelium discoideum AX4
Length = 1492
Score = 127 bits (306), Expect = 9e-28
Identities = 71/251 (28%), Positives = 126/251 (50%), Gaps = 9/251 (3%)
Query: 71 HDSIFHYKTNSLPAACSINQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTC 130
H S H K P + + S D + + ++ QLTL++ + +KP E
Sbjct: 1233 HTSTSHCK---FPPSIPPSLSKPDQIPTLQNFDDLEIARQLTLIEHEAYSMVKPNECINL 1289
Query: 131 GWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNN 190
++K +K APN++ KR N + W EI+ + RA I+ FI +A + LNN
Sbjct: 1290 AFSKSDKEIRAPNIINIIKRSNLLPLWVATEIVQEERLTKRANIIKKFISIADQCKNLNN 1349
Query: 191 LHSLFAVISALHSASIYRLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISLP 250
+++ ++S L+ ++RL KTW L +K F L L N+ R+ L + +LP
Sbjct: 1350 FNAVMEILSGLNLTPVFRLKKTWETLPRKYLATFRHLNSLMAPKFNFKVYRDVLHTKNLP 1409
Query: 251 CIPYLGIFLTDLVYIDIAH----PAGSPHRVTKMNI--VLKALERYQSSEYEIAPLPHVA 304
C+P+LG++LTDL +++ G + V + I +++ +++YQ Y AP+P +
Sbjct: 1410 CLPFLGVYLTDLTFLEEGSFDQAENGLINIVKRTQIANIIQEIQQYQQLSYSFAPVPIIK 1469
Query: 305 NFLNSVRYIEE 315
+FL + ++E
Sbjct: 1470 DFLLQIGGLQE 1480
>UniRef50_Q8IS10 Cluster: Nucleotide exchange factor RasGEF P; n=2;
Dictyostelium discoideum|Rep: Nucleotide exchange factor
RasGEF P - Dictyostelium discoideum (Slime mold)
Length = 1502
Score = 126 bits (304), Expect = 2e-27
Identities = 73/243 (30%), Positives = 127/243 (52%), Gaps = 14/243 (5%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQE 161
+ P ++ QLTL++ FK I +E + W K +K +PN++ RFN VS W
Sbjct: 1266 MDPAEIARQLTLIEFNLFKNIANKEFLSLSWQKQDKEKRSPNLLKMIYRFNEVSNWVTST 1325
Query: 162 ILNGQSP-KARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKD 220
I+ + K RA + FIK+A++L +LNN + +F ++S LHSAS+ RL TWA +SK+
Sbjct: 1326 IVKETTNIKKRASYLKRFIKLAEELRKLNNFNGVFVIVSGLHSASVNRLKNTWAEISKQQ 1385
Query: 221 KQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPHRVT-- 278
++QF++ L ++ + R L+ + IPYLG+ L+DL +++ + + T
Sbjct: 1386 QKQFEEFVALTSPQSSFASYRLELRQSTGASIPYLGVHLSDLTFVEEGNQDKLENGYTNF 1445
Query: 279 -KMNIV---LKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEPP 334
K ++ +KA++ +Q Y + + + F+ + E + + LSL EP
Sbjct: 1446 SKCRLIAEQIKAIQEFQQEPYNLREVEEMIPFITH-------KAVPESECFNLSLICEPR 1498
Query: 335 SPV 337
V
Sbjct: 1499 ESV 1501
>UniRef50_A2R650 Cluster: Similarity: N-terminal half differs from all
homologs; n=14; Pezizomycotina|Rep: Similarity:
N-terminal half differs from all homologs - Aspergillus
niger
Length = 1362
Score = 126 bits (304), Expect = 2e-27
Identities = 74/244 (30%), Positives = 127/244 (52%), Gaps = 15/244 (6%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKL---NKLTVAPNVVAFTKRFNRVSF 156
L + + QLT+++ + I+P E W K ++ A NV A N+++
Sbjct: 963 LDIDATEFARQLTIIESRLYSKIRPTECLNKTWQKKVGPDEPEPASNVKALILHSNQLTN 1022
Query: 157 WTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACL 216
W + ILN K R ++ HF+ VA K LNN +L ++ISAL +A I+RL +TWA +
Sbjct: 1023 WVAEMILNQSDVKKRVVVIKHFVNVADKCRALNNYSTLTSIISALGTAPIHRLGRTWAQV 1082
Query: 217 SKKDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPHR 276
S + +++ L T N+ RE L + PCIP+ G++LTDL +I+ P+ +P
Sbjct: 1083 SGRTSTVLEQMRRLMASTKNFGEYRETLHLANPPCIPFFGVYLTDLTFIEDGIPSLTPSE 1142
Query: 277 VTKMN------IVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVE-DDQYKLSL 329
+ N V++ +++YQ+ Y + P+P + +++ + LQ + D Y SL
Sbjct: 1143 LINFNKRAKTAEVIRDIQQYQNVPYLLQPVPELQDYI-----LSNLQNAGDVHDMYDRSL 1197
Query: 330 KLEP 333
++EP
Sbjct: 1198 EVEP 1201
>UniRef50_Q0UTD8 Cluster: Putative uncharacterized protein; n=1;
Phaeosphaeria nodorum|Rep: Putative uncharacterized
protein - Phaeosphaeria nodorum (Septoria nodorum)
Length = 1210
Score = 125 bits (301), Expect = 4e-27
Identities = 83/277 (29%), Positives = 141/277 (50%), Gaps = 16/277 (5%)
Query: 97 CSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSF 156
CS L P ++ Q T+++ F +I+ EEL WTK + + A NV A + ++
Sbjct: 914 CSILDFDPLELARQFTIIESRLFCSIQSEELLALEWTKKSD-SKAVNVKAMSTLSTDLAN 972
Query: 157 WTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACL 216
IL+ + K RA I+ ++K+A K ELNN SL A+I +L+S+ + RL +TW +
Sbjct: 973 LVADTILHLEDAKKRAAIIKQWVKIAAKCLELNNYDSLMAIICSLNSSMVMRLKRTWELV 1032
Query: 217 SKKDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPA----- 271
S K K + ++L + N+ LR+ L++ PCIP++GI+LTDL +ID+ +
Sbjct: 1033 STKTKTRLEELKAITDVGRNYAVLRQRLQNHVAPCIPFVGIYLTDLTFIDVGNGTTRQLP 1092
Query: 272 --GSPHRVTKMNI-----VLKALERYQSSE--YEIAPLPHVANFLNS-VRYIEELQKFVE 321
V+ +N K + + QS + Y++A +P + +++ + ++ + +
Sbjct: 1093 GEAGEDSVSVINFDKHMKTAKIIGQLQSFQVPYQLAAVPEMQDWMEAQIQRVRSSDQANV 1152
Query: 322 DDQYKLSLKLEPPSPVGSCAGSKESVKETVLQGNVTT 358
Y+ SL LEP P S GS + T N TT
Sbjct: 1153 QSYYRRSLLLEPRDPQHSVRGSPSIDQGTFTAENRTT 1189
>UniRef50_Q55CK1 Cluster: Ras guanine nucleotide exchange factor;
n=2; Dictyostelium discoideum|Rep: Ras guanine
nucleotide exchange factor - Dictyostelium discoideum
AX4
Length = 1037
Score = 124 bits (300), Expect = 5e-27
Identities = 63/167 (37%), Positives = 93/167 (55%), Gaps = 2/167 (1%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQE 161
L P ++ QLTL + F+ I +E W K K APN+V+F KRFN+VS W E
Sbjct: 725 LDPTEIARQLTLYESDLFRKIGAKECLGQAWNKDGKEENAPNIVSFIKRFNQVSSWVATE 784
Query: 162 ILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKD- 220
I+ + K R + FI VA++ +LNN ++ ++S L ++S+YRL KTW + K
Sbjct: 785 IVRQEKLKDRVSYIKRFILVAQECRKLNNFNATMEILSGLQNSSVYRLRKTWERVESKPL 844
Query: 221 -KQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYID 266
K D+L L N+ + L +I PCIPYLG++LT L +I+
Sbjct: 845 LKNTLDELMSLMSSGANYKNYIQELHNIHPPCIPYLGVYLTHLTFIE 891
>UniRef50_UPI000049A5AB Cluster: Ras guanine nucleotide exchange
factor; n=1; Entamoeba histolytica HM-1:IMSS|Rep: Ras
guanine nucleotide exchange factor - Entamoeba
histolytica HM-1:IMSS
Length = 602
Score = 123 bits (297), Expect = 1e-26
Identities = 72/246 (29%), Positives = 123/246 (50%), Gaps = 10/246 (4%)
Query: 93 DDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFN 152
DD L +SP D Q+TL+ + F I +E GWTK NK + P++V K N
Sbjct: 326 DDKFSGILCISPLDFAEQMTLIQMESFVEIPSDEFLNQGWTKKNKEQLTPHIVNMIKLSN 385
Query: 153 RVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKT 212
++ EI+ + R+ + +FI A+ + + N + A+++AL S S++RL +
Sbjct: 386 KLIHIVQTEIVMQPTYALRSLALFYFITAAETMRTIQNFDGMKAIVTALQSVSVFRLKVS 445
Query: 213 WACLSKKDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAG 272
W L + K F L L E +N+T LR+ + P IP++G LTDL+Y + A
Sbjct: 446 WEMLQQSTKSIFTNLVHLCSEDNNFTELRKIMNIAIPPTIPFIGSTLTDLIYTSDGNKAS 505
Query: 273 SP-----HRVTKMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKL 327
+ +++ + ++K ++ Q + + P+V +F+NS++ I ED + L
Sbjct: 506 TNNKFNFYKLRGIGNLIKEIQMKQKTSFSFNIAPNVRDFINSIQVISN-----EDQLFNL 560
Query: 328 SLKLEP 333
S K EP
Sbjct: 561 SQKHEP 566
>UniRef50_Q54FF3 Cluster: Ras guanine nucleotide exchange factor; n=4;
Eukaryota|Rep: Ras guanine nucleotide exchange factor -
Dictyostelium discoideum AX4
Length = 1557
Score = 123 bits (296), Expect = 1e-26
Identities = 75/242 (30%), Positives = 123/242 (50%), Gaps = 12/242 (4%)
Query: 105 DDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLT-VAPNVVAFTKRFNRVSFWTVQEIL 163
+++ QLTL D + AIKP E W K + + +P ++ RFN +S W V IL
Sbjct: 1318 EEIARQLTLYDFQLYTAIKPTEFLNQAWNKPSMASRKSPTILKIISRFNDISLWVVSLIL 1377
Query: 164 NGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQ 223
K RA+ + I +A +L +LNN ++ AVIS +++++I RL T LSKK
Sbjct: 1378 EPDRVKTRAKRLKRIISIADELRKLNNYNTCIAVISGINNSAILRLKYTRGLLSKKYLDI 1437
Query: 224 FDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHP---AGSPHRVTKM 280
+ L + ++ R+ LK+ P +PY+G++LTDL +I+ +P G+ K
Sbjct: 1438 LENLEKEMSCEGSYKNYRDKLKNSDPPVVPYIGVYLTDLTFIEEGNPNIIRGNLINFAKY 1497
Query: 281 NI---VLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEPPSPV 337
+ V+ +++YQ +EY++ P + F+ V DD Y LSL EP + +
Sbjct: 1498 YLIYRVISEIQQYQWTEYQLNVAPIIQTFIRDVSI-----SSTSDDLYHLSLLKEPRNAL 1552
Query: 338 GS 339
S
Sbjct: 1553 KS 1554
>UniRef50_Q0UD52 Cluster: Putative uncharacterized protein; n=1;
Phaeosphaeria nodorum|Rep: Putative uncharacterized
protein - Phaeosphaeria nodorum (Septoria nodorum)
Length = 1132
Score = 122 bits (294), Expect = 3e-26
Identities = 72/249 (28%), Positives = 129/249 (51%), Gaps = 24/249 (9%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKL---NKLTVAPNVVAFTKRFNRVSF 156
L + + QLT ++ + I+P E W K + A NV A N+++
Sbjct: 870 LDIDATEFARQLTTIESRLYGKIRPTECLNKTWQKKLAPGEPDPAANVKALILHSNQLTN 929
Query: 157 WTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACL 216
W Q IL Q K R ++ HF+ VA K +LNN +L ++ISAL +A I+RL +TW+ +
Sbjct: 930 WVAQMILTQQDVKRRVIVIKHFVMVADKCRQLNNFSTLTSIISALGTAPIHRLNRTWSAV 989
Query: 217 SKKDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPHR 276
+++ + + +L G T N+ R+ L + PCIP+ G++LTDL +I+ G P
Sbjct: 990 NQRSMGVLESMRKLMGSTKNFAEYRDTLHRANPPCIPFFGVYLTDLTFIE----DGIPSL 1045
Query: 277 VTKMNI-----------VLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVE-DDQ 324
+ K N+ V++ +++YQ+ Y + P+P + +++ + +Q + +
Sbjct: 1046 IKKTNLINFAKRAKTAEVIRDIQQYQNVPYPLQPVPELQDYI-----LTNMQSAGDVHEM 1100
Query: 325 YKLSLKLEP 333
Y++SL +EP
Sbjct: 1101 YEMSLSVEP 1109
>UniRef50_UPI0000499791 Cluster: Ras guanine nucleotide exchange
factor; n=1; Entamoeba histolytica HM-1:IMSS|Rep: Ras
guanine nucleotide exchange factor - Entamoeba
histolytica HM-1:IMSS
Length = 598
Score = 121 bits (291), Expect = 6e-26
Identities = 77/266 (28%), Positives = 128/266 (48%), Gaps = 10/266 (3%)
Query: 89 NQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFT 148
N+ I+ + SP D QL+L + + I+ +E GW K K +APN++
Sbjct: 317 NEEIQSIIHTLFCFSPFDCAKQLSLKQMELLQKIELDEFLKQGWMKKEKENLAPNLLKMV 376
Query: 149 KRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYR 208
+ N + ++IL + RA + +FI VA L +LNN + AV++ L S SIYR
Sbjct: 377 RFSNNIINVVQKKILELEQNYERAFAIRYFISVAHYLKQLNNFDGMKAVLAGLESCSIYR 436
Query: 209 LTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIA 268
L ++W LS + F +L L +N+ +RE +K S P IP++G LTDLVY D
Sbjct: 437 LKESWGLLSIDEINLFKQLDSLISPDNNFCKMRELVKLASPPSIPFIGSILTDLVYTDDG 496
Query: 269 HPAGSP-----HRVTKMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDD 323
+ + ++V + I+L L+ Q + Y +P + F + + E++
Sbjct: 497 NKSSEGKMINFYKVRSIGIILMDLQTRQKATYPFILVPKILKF-----WCCNEKNINENE 551
Query: 324 QYKLSLKLEPPSPVGSCAGSKESVKE 349
+ LS +LEP + K+ + E
Sbjct: 552 LFNLSQELEPTQTQSEISKEKKKILE 577
>UniRef50_UPI0000E47C73 Cluster: PREDICTED: similar to conserved
hypothetical protein; n=1; Strongylocentrotus
purpuratus|Rep: PREDICTED: similar to conserved
hypothetical protein - Strongylocentrotus purpuratus
Length = 1211
Score = 120 bits (290), Expect = 8e-26
Identities = 71/205 (34%), Positives = 109/205 (53%), Gaps = 6/205 (2%)
Query: 101 RLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQ 160
R+S ++ QL+ L+ +AI E W K K T APN++A T+RFN VS
Sbjct: 991 RMSALELAEQLSYLEHKLLRAIPYWEFLNQAWMKQGKATRAPNILAVTRRFNEVSKLVSS 1050
Query: 161 EILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKD 220
EIL +S ARA + + VA ++N +S+ + SAL ++S+YRL K W + K+
Sbjct: 1051 EILRQKSVAARALAIERWAGVADICRCMHNFNSVLEITSALMNSSVYRLKKVWEKVPKQT 1110
Query: 221 KQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPHRV--- 277
K DKL L + +R+ L I PC+PYLG +LTDL +I+ P + R+
Sbjct: 1111 KTLLDKLQVLVSSDGRFKNMRDALHRIDPPCVPYLGFYLTDLAFIEDGTPNITDDRLINF 1170
Query: 278 TKMNI---VLKALERYQSSEYEIAP 299
+KM + V++ + +Q + Y I P
Sbjct: 1171 SKMRMIAHVVREIRHFQHTNYNIEP 1195
>UniRef50_Q55AB0 Cluster: Ras guanine nucleotide exchange factor; n=2;
Dictyostelium discoideum|Rep: Ras guanine nucleotide
exchange factor - Dictyostelium discoideum AX4
Length = 1556
Score = 120 bits (290), Expect = 8e-26
Identities = 77/250 (30%), Positives = 125/250 (50%), Gaps = 16/250 (6%)
Query: 90 QSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTK 149
Q ++DI+ L +++ QLTL++ F I+ E W K +APN+ A
Sbjct: 1308 QQFNDIIS----LPAEEIAKQLTLIEFEIFGKIQSSEFLNQSWAKEKTFHLAPNIRASID 1363
Query: 150 RFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRL 209
RFN V+ W IL + + R +IM+ +KVAK L +N H+L A++S L+ IYRL
Sbjct: 1364 RFNTVTKWVCTIILKEEKIRTRTKIMSKLLKVAKNLRSYSNFHTLMAILSGLNEIHIYRL 1423
Query: 210 TKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSI--SLPCIPYLGIFLTDLVYI-D 266
T L K ++ +L L N A R L ++ CIPYLG++L DL +I D
Sbjct: 1424 KFTQQELKPKIQKISSELQTLMSVEGNHEAYRTELSNVDPKQSCIPYLGVYLKDLTFIQD 1483
Query: 267 IAHPAGSPHRVTK-MNI--VLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDD 323
+ G + + +N+ +LK ++ +Q + Y P + L + L + ED+
Sbjct: 1484 DTNKKGDGINIKQSLNLYNILKTIQNFQKNPYSFEEFPKIKETLLN------LPVWTEDN 1537
Query: 324 QYKLSLKLEP 333
Y++S++ EP
Sbjct: 1538 LYRVSMQREP 1547
>UniRef50_A6R7Z9 Cluster: Putative uncharacterized protein; n=1;
Ajellomyces capsulatus NAm1|Rep: Putative uncharacterized
protein - Ajellomyces capsulatus NAm1
Length = 1201
Score = 120 bits (290), Expect = 8e-26
Identities = 69/244 (28%), Positives = 130/244 (53%), Gaps = 15/244 (6%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKL---NKLTVAPNVVAFTKRFNRVSF 156
L + P + QLT+++ + IKP E W K ++ A NV A N+++
Sbjct: 937 LDIDPMEFARQLTIIESRLYARIKPTECLNKTWQKKLVPDEPDPAANVKALILHSNQLTN 996
Query: 157 WTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACL 216
W + IL+ Q K R ++ HF+ +A++ +NN +L ++ISAL +A ++RL +TWA +
Sbjct: 997 WVAEMILHQQDVKRRVVVIKHFVLIAERCRAMNNYSTLTSIISALGTAPVHRLNRTWAQV 1056
Query: 217 SKKDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPHR 276
S + + + L T N+ RE L + PCIP+ G++LTDL +I+ P+ +
Sbjct: 1057 SARILAVLENMRRLMASTKNFGEYREALHLANPPCIPFFGVYLTDLTFIEDGIPSLTQSH 1116
Query: 277 VTKMN------IVLKALERYQSSEYEIAPLPHVANF-LNSVRYIEELQKFVEDDQYKLSL 329
+ N V++ +++YQ++ Y P+P + ++ L++++ ++ + Y SL
Sbjct: 1117 LINFNKRAKTAEVIRDIQQYQNAPYPFHPVPELQDYVLSNMQAAGDVH-----EMYDRSL 1171
Query: 330 KLEP 333
++EP
Sbjct: 1172 EVEP 1175
>UniRef50_A3LZZ6 Cluster: Predicted protein; n=2; Pichia|Rep:
Predicted protein - Pichia stipitis (Yeast)
Length = 1325
Score = 120 bits (288), Expect = 1e-25
Identities = 71/238 (29%), Positives = 125/238 (52%), Gaps = 14/238 (5%)
Query: 106 DVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVA-PNVVAFTKRFNRVSFWTVQEILN 164
++ QLTL + + I W K + L N+ AF K N+++ + IL
Sbjct: 1053 ELARQLTLREFRLYSKITKFTCLAKVWGKKSGLNERFENITAFIKASNQLTNYVAYMILR 1112
Query: 165 GQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQF 224
K R +++ +F++VA+K + NN S+ A+ISAL+S+SI+RL KTW +S
Sbjct: 1113 KTDAKKRIQVIRYFVQVAEKCRQYNNFSSMTAIISALYSSSIHRLKKTWKYVSADTLSHL 1172
Query: 225 DKLAELFGETDNWTALREYLKSI-SLPCIPYLGIFLTDLVYIDIAHPAGSPHRVTKMNIV 283
+ +L + N+ R+ LK I S PC+P+ G+FLTDL ++ +P +R +N
Sbjct: 1173 QSMNKLMNSSRNFNEYRDVLKFIGSEPCVPFFGVFLTDLTFVYHGNPDYLMNRTRMINFA 1232
Query: 284 LKA--------LERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEP 333
+A ++R++++ Y +P + +L+S + ++ ++QY+LSL LEP
Sbjct: 1233 KRAKTCEIVTGIDRFKTTGYNFQTVPEIQKYLDS--WFDKCPTI--EEQYQLSLNLEP 1286
>UniRef50_Q54YQ2 Cluster: Ras guanine nucleotide exchange factor;
n=4; Dictyostelium discoideum|Rep: Ras guanine
nucleotide exchange factor - Dictyostelium discoideum
AX4
Length = 824
Score = 119 bits (287), Expect = 2e-25
Identities = 70/235 (29%), Positives = 120/235 (51%), Gaps = 12/235 (5%)
Query: 105 DDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILN 164
+++ QLTL+D F IK EL W K +PNV+ RFN +S WT IL+
Sbjct: 587 EEISRQLTLMDFEIFSNIKSTELLNQCWNKPKLRHRSPNVLELIGRFNEISQWTATSILS 646
Query: 165 GQSPKARAEIMAHFIKVAKK-LHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQ 223
K RA IM FIK+A+ + LNN ++ A++S L+++S++RL T L + +Q
Sbjct: 647 WPKVKDRARIMGKFIKIAEYCMKHLNNFNTSMAILSGLNASSVHRLKFTKEELPRHTQQV 706
Query: 224 FDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPHRVT--KMN 281
+ +L + R L + PC+PYLG++LTDL + + +P + K
Sbjct: 707 YTELQFHLSSAQAYKEYRALLAKANPPCLPYLGVYLTDLTFFEEGNPDFIQGFINFGKRK 766
Query: 282 IV---LKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEP 333
++ + ++ +Q+++Y + P+ +A L + +E E++ Y S+ EP
Sbjct: 767 LIYGSISNVQSFQNTKYNLQPVYQIAKLLKGFKLLE------ENELYTRSMSFEP 815
>UniRef50_Q54H95 Cluster: Putative uncharacterized protein; n=1;
Dictyostelium discoideum AX4|Rep: Putative
uncharacterized protein - Dictyostelium discoideum AX4
Length = 1371
Score = 118 bits (284), Expect = 4e-25
Identities = 65/198 (32%), Positives = 103/198 (52%), Gaps = 5/198 (2%)
Query: 98 SALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLT--VAPNVVAFTKRFNRVS 155
S L +S +V Q+ L+D I EL + W+K T + PN++ FN+ S
Sbjct: 784 SLLDISSIEVARQMALIDQTLLSKISSTELLSKKWSKCTDETQKICPNILTMIGVFNQCS 843
Query: 156 FWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWAC 215
W EI+ +S K R + + +FIK+A+ +++ N + L +IS L +S+ RL TW
Sbjct: 844 KWVSSEIVGEKSSKLRIKKLKYFIKIAQHCYDMQNFNGLMLIISGLSCSSVTRLRGTWGS 903
Query: 216 LSKKDKQQFDKLAELFGETDNWTALREYLKSI---SLPCIPYLGIFLTDLVYIDIAHPAG 272
LS + + +FD+L N+ R L I + PCIP++G++L DL +ID +PA
Sbjct: 904 LSSRHRDRFDQLERFVNMEGNFKQYRMLLAEIQTDTTPCIPFVGLYLMDLTFIDEGNPAY 963
Query: 273 SPHRVTKMNIVLKALERY 290
T +N V K LE +
Sbjct: 964 LNPEQTLVNFVKKRLEAH 981
>UniRef50_UPI0000499F54 Cluster: Ras guanine nucleotide exchange
factor; n=2; Entamoeba histolytica HM-1:IMSS|Rep: Ras
guanine nucleotide exchange factor - Entamoeba
histolytica HM-1:IMSS
Length = 493
Score = 118 bits (283), Expect = 6e-25
Identities = 74/240 (30%), Positives = 120/240 (50%), Gaps = 10/240 (4%)
Query: 98 SALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFW 157
+ L+ P + Q+TL+ F+ + EL GW K +K T+ PN++ + R+ +
Sbjct: 225 NVLQFHPHEFARQITLMQNDLFRKVPYFELLGNGWMKKDKDTLTPNLIRLVRSSKRLFSF 284
Query: 158 TVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLS 217
IL + RA + +F++VA+++ +LNN + AV SAL S IYRL TW L
Sbjct: 285 VQTSILVEKRVAYRALFIHYFLQVAEEMKKLNNFEGMKAVFSALESTPIYRLKDTWDSLL 344
Query: 218 KKDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPHRV 277
+DK+ + L+EL + N++ LRE +K PC+P++G + DLV+ D + G +
Sbjct: 345 PEDKEIEEMLSELCDQEKNFSKLREVMKIAVPPCLPFIGSTMGDLVFTDDGNKQGDKTLI 404
Query: 278 TKMNI-----VLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLE 332
I ++K L Q+ Y I + + S +E ED+ Y LSL LE
Sbjct: 405 NWFKIRGIGNLIKELMVKQAVPYPIQHYDALMKYYESAPVLES-----EDELYDLSLNLE 459
>UniRef50_Q550U8 Cluster: Ras guanine nucleotide exchange factor;
n=2; Dictyostelium discoideum|Rep: Ras guanine
nucleotide exchange factor - Dictyostelium discoideum
AX4
Length = 604
Score = 118 bits (283), Expect = 6e-25
Identities = 61/226 (26%), Positives = 114/226 (50%), Gaps = 5/226 (2%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQE 161
+ +++ QL +D ++ IKP E GWTK A N++ +RFN + W
Sbjct: 364 IDEEEIARQLCCIDFALYELIKPSEFLIKGWTKPQYRNKAVNLLNMMRRFNDFTKWIAAS 423
Query: 162 ILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDK 221
ILN Q+ K R++++ F+K+++ L NN HSL A+ +++ ++R LS++ +
Sbjct: 424 ILNEQNSKGRSKLLGRFLKISEHLRANNNFHSLMAIYGGINNTHVFRTKAIRKDLSRQQQ 483
Query: 222 QQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHP--AGSPHRVTK 279
+ + +L +LF +++ R K PCIP+LGI L DL ++D ++P + + K
Sbjct: 484 ETYAELEKLFASENSFRNYRIAYKDAKPPCIPFLGIHLRDLAFVDESNPDRINNLLNLNK 543
Query: 280 MNIVLKAL---ERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVED 322
++ + + RYQ Y + ++ FL ++ E + D
Sbjct: 544 RRVIWRVIVNTMRYQPIPYYFLKVHQISLFLTELKTESEQPQLTLD 589
>UniRef50_Q875L6 Cluster: Guanyl nucleotide exchange factor Sql2; n=2;
Ustilago maydis|Rep: Guanyl nucleotide exchange factor
Sql2 - Ustilago maydis (Smut fungus)
Length = 1441
Score = 117 bits (281), Expect = 1e-24
Identities = 79/253 (31%), Positives = 129/253 (50%), Gaps = 22/253 (8%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNK---LTVAPNVVAFTKRFNRVSF 156
L P ++ QLT+LD + AI+PEEL +TK K +T +V + + R++
Sbjct: 1135 LDFDPLELARQLTILDSKLYCAIQPEELLGSKFTKETKASGVTEDVHVKSMSSMSTRITG 1194
Query: 157 WTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACL 216
W + IL + R +++ FIK+ + +LNN H+L A+ AL+S++I RL KTW L
Sbjct: 1195 WISECILGESDARKRTQLLKFFIKLGDRCEQLNNFHTLMAIQCALNSSTIARLKKTWDGL 1254
Query: 217 SKKDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSP-- 274
S K + D+ T N+ A R L++ + P IP+LG+FLTDL + + A P
Sbjct: 1255 STKYRGMMDQQRSAVEHTRNYAAYRARLRNTTPPAIPFLGLFLTDLTFCHEGNAATRPCP 1314
Query: 275 ----------HRVTKMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFV---- 320
+ K++ ++ ++R+Q Y + +P + FL +E++Q
Sbjct: 1315 SNAEKKLLNFDKYIKISRIVGEVQRFQ-VPYNLVEVPEMQQFLKGA--LEDVQGAQGGRG 1371
Query: 321 EDDQYKLSLKLEP 333
DD Y+ SL LEP
Sbjct: 1372 ADDLYRRSLLLEP 1384
>UniRef50_Q6C867 Cluster: Similarities with sp|P43069 Candida albicans
Cell division control protein 25; n=1; Yarrowia
lipolytica|Rep: Similarities with sp|P43069 Candida
albicans Cell division control protein 25 - Yarrowia
lipolytica (Candida lipolytica)
Length = 1189
Score = 116 bits (279), Expect = 2e-24
Identities = 71/235 (30%), Positives = 122/235 (51%), Gaps = 15/235 (6%)
Query: 110 QLTLLDLPCFKAIKPEELTTCGWTKLNKLTVA---PNVVAFTKRFNRVSFWTVQEILNGQ 166
QLT+ + F AI P E W + N+ F + N ++ W IL +
Sbjct: 939 QLTIRESRLFCAISPIECLNKEWNSKRGTSGGGEPSNIRKFIQNSNCLTNWVAACILAEK 998
Query: 167 SPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFDK 226
K RA ++ +F++V+++ ++NN S+ A+ISAL+S++I+RL K+W +S + +
Sbjct: 999 DTKKRASVIKYFVQVSEQCRQINNFSSMTAIISALYSSTIHRLKKSWELVSARTMASLEN 1058
Query: 227 LAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHP---AGSPHRV-----T 278
+ +L T N+ R+ L ++ P IP+ G++LTDL ++ +P G P + T
Sbjct: 1059 MNKLMNSTRNFNEYRDMLHLVNPPIIPFFGVYLTDLTFVADGNPDFIKGEPKLINFSKRT 1118
Query: 279 KMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEP 333
K +++ +++YQS Y LP V + + R+ E DDQY+ SL LEP
Sbjct: 1119 KTAEIVREIQQYQSIPYSFQELPEVQQRV-AARFKEAPS---IDDQYETSLALEP 1169
>UniRef50_P43069 Cluster: Cell division control protein 25; n=5;
Saccharomycetales|Rep: Cell division control protein 25 -
Candida albicans (Yeast)
Length = 1333
Score = 116 bits (279), Expect = 2e-24
Identities = 70/255 (27%), Positives = 130/255 (50%), Gaps = 14/255 (5%)
Query: 106 DVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVA-PNVVAFTKRFNRVSFWTVQEILN 164
++ QLTL + + I W K + L+ + ++ F K N+++ + IL
Sbjct: 1071 ELARQLTLREFKLYCKITKFACLAKVWGKKSGLSESIDSITQFIKASNQLTNFVGYMILR 1130
Query: 165 GQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQF 224
PK R +I+ +FI+VA K + NN S+ A+ISAL+S+ I+RL KTW ++
Sbjct: 1131 KADPKKRVQIIRYFIQVADKCRQYNNFSSMTAIISALYSSPIHRLKKTWEYMNADALSNL 1190
Query: 225 DKLAELFGETDNWTALREYLKSI-SLPCIPYLGIFLTDLVYIDIAHPAGSPHRVTKMNI- 282
+ +L + N+ R+ LK I S PC+P+ G++L+DL ++ +P +R ++N
Sbjct: 1191 KNMNKLMNSSRNFNEYRDVLKFIGSEPCVPFFGVYLSDLTFVYHGNPDYLYNRTRQVNFA 1250
Query: 283 -------VLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEPPS 335
++ ++R++++ Y +P + FL++ + E+ D+QY++SL LEP
Sbjct: 1251 KRAKTSEIVSGIDRFKTTGYNFQEVPEIQKFLDA--WFEKCPTI--DEQYQISLNLEPRE 1306
Query: 336 PVGSCAGSKESVKET 350
+ S + T
Sbjct: 1307 QPAGASNSNSTTNAT 1321
>UniRef50_A7SLX0 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 626
Score = 115 bits (276), Expect = 4e-24
Identities = 60/167 (35%), Positives = 97/167 (58%), Gaps = 2/167 (1%)
Query: 98 SALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFW 157
S + + ++TL+D F I EL TCGW +K +P+V+ + FNR++
Sbjct: 116 SLIDIDATTFAKEITLIDKELFVRILWHELETCGWMTKDKYVRSPDVMEMVEFFNRIAML 175
Query: 158 TVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLS 217
EIL ++ +ARA +++ I++A K L N +SL A+++ L SA IYRL +TW +S
Sbjct: 176 VASEILAEETTQARARVVSKVIQIADKCRLLGNYNSLKALMAGLQSAPIYRLKQTWKEVS 235
Query: 218 KKDKQQFDKLAELFGETDNWTALREYLKS--ISLPCIPYLGIFLTDL 262
K +++F L+ + GE+DN+ R L S + PC+P+LG FLT +
Sbjct: 236 SKRRKKFRHLSIIMGESDNFALYRGELSSCLANGPCLPFLGDFLTQI 282
>UniRef50_A1CGW5 Cluster: Ras guanine-nucleotide exchange protein,
putative; n=3; Eurotiomycetidae|Rep: Ras
guanine-nucleotide exchange protein, putative -
Aspergillus clavatus
Length = 1187
Score = 115 bits (276), Expect = 4e-24
Identities = 63/178 (35%), Positives = 96/178 (53%), Gaps = 1/178 (0%)
Query: 94 DIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNR 153
D S L P ++ QLT+ + F I PEEL W K ++A NV A +
Sbjct: 890 DGALSILDFDPMELARQLTIKESRIFCTILPEELLATEWMK-KTASLAVNVRAMSTLSTD 948
Query: 154 VSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTW 213
++ IL + PK RA I+ H++K+A K ELNN SL A+I +L+S+ I RL +TW
Sbjct: 949 LAHLVADSILQLEEPKKRAAIIKHWVKIANKCLELNNYDSLMAIICSLNSSMISRLRRTW 1008
Query: 214 ACLSKKDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPA 271
+S K K + L + + N+ LR+ L+ PC+P++G +LTDL ++D + A
Sbjct: 1009 EVVSHKTKTTLEMLRGIVDVSRNYAVLRQRLQGHVPPCLPFVGTYLTDLTFVDHGNQA 1066
>UniRef50_Q555R4 Cluster: Ras guanine nucleotide exchange factor; n=3;
Eukaryota|Rep: Ras guanine nucleotide exchange factor -
Dictyostelium discoideum AX4
Length = 1721
Score = 114 bits (275), Expect = 5e-24
Identities = 75/264 (28%), Positives = 129/264 (48%), Gaps = 7/264 (2%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTV 159
L L+ ++ QLTL+D F I+P EL W K + +PNV+ R N+ SFW
Sbjct: 1444 LLLNESEIARQLTLIDFNIFSKIQPTELLDQSWNKDSLKFKSPNVIEMINRANKFSFWVS 1503
Query: 160 QEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKK 219
+IL + + R ++ FI ++K L E+NN ++L A+ + L++A I RL KT+A LS
Sbjct: 1504 SQILWQEDIEERVKVFEKFILISKYLREMNNFNTLLAIFTGLNTAPILRLKKTFALLSPN 1563
Query: 220 DKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPHRVT- 278
++ L +L + ++ R K + P +PYL + L+DL +++ +P + +
Sbjct: 1564 SLSIYNSLEKLMNSSGSYKNYRSVSK--NPPLLPYLPVILSDLTFMEDGNPDKINNLINF 1621
Query: 279 -KMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEPPSPV 337
K ++ + + Q + + V ++++ + EL + Y+LSL EP
Sbjct: 1622 QKRELICRVISEVQQCQQQTKYEFPVVEPIHTL--LTELPSSTPSELYQLSLIREPRETN 1679
Query: 338 GSCAGSKESVKETVLQGNVTTFNI 361
S A S S L N + NI
Sbjct: 1680 QSNANSSISSGSNFL-SNSSNHNI 1702
>UniRef50_UPI0000498A32 Cluster: Ras guanine nucleotide exchange
factor; n=3; Entamoeba histolytica HM-1:IMSS|Rep: Ras
guanine nucleotide exchange factor - Entamoeba
histolytica HM-1:IMSS
Length = 763
Score = 114 bits (274), Expect = 7e-24
Identities = 71/261 (27%), Positives = 135/261 (51%), Gaps = 12/261 (4%)
Query: 82 LPAACSINQSWDDIVCSALRLSPDD--VGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLT 139
LP + +D ++ + DD + +Q T ++ F ++P E W K
Sbjct: 502 LPQPDKMKNLFDKLIPKVKFIDIDDDVIVSQFTYMEASIFYKLEPSEFFGQAWAKAKLRH 561
Query: 140 VAPNVVAFTKRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVIS 199
APN++A T+ FN +S + V ILN +S + R ++ + + K H + N L+++
Sbjct: 562 KAPNIIASTQMFNFISSFFVNMILNTESLEERITLVKKILSLGIKAHAIKNYDLLYSLTG 621
Query: 200 ALHSASIYRLTKTWACLSK-KDKQQFDKLAELFGETDNWTALREYLKSI-SLPCIPYLGI 257
+L A+I+R+ +TW +++ +K +FD+L+ LF N+ R +K I + PC+P++G
Sbjct: 622 SLGDAAIFRMKRTWEVVNQDPNKAEFDRLSGLFQR--NFGGFRNEVKDIFTTPCLPFIGT 679
Query: 258 FLTDLVYIDIAH--PAGSPHRVTKMNIVLKALE---RYQSSEYEIAPLPHVANFLNSVRY 312
+LTD ++D + AG V K + + + R++ ++Y+I +P + F+ + Y
Sbjct: 680 YLTDYTFLDDGNLDMAGDKINVDKKLRLFECINNVIRFKDTKYDIVAIPQIICFIKNY-Y 738
Query: 313 IEELQKFVEDDQYKLSLKLEP 333
++ E +Y+ SLK EP
Sbjct: 739 FDDGILTDEKLKYEKSLKTEP 759
>UniRef50_Q02342 Cluster: Cell division control protein 25; n=1;
Lachancea kluyveri|Rep: Cell division control protein 25
- Saccharomyces kluyveri (Yeast) (Saccharomyces
silvestris)
Length = 1095
Score = 114 bits (274), Expect = 7e-24
Identities = 75/244 (30%), Positives = 118/244 (48%), Gaps = 14/244 (5%)
Query: 106 DVGNQLTLLDLPCFKAIKPEELTTCGW-TKLNKLTVAPNVVAFTKRFNRVSFWTVQEILN 164
D QLT+ + F I P E W K + + N+ F N ++ + I+
Sbjct: 815 DYAKQLTIKEHSLFYKISPFECLDRTWGNKYCNMGGSKNITEFISNSNHLTNYVSFMIVK 874
Query: 165 GQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQF 224
K R +++ FI VA HELNN SL A+ISAL+S+ IYRL +TWA + ++ K+
Sbjct: 875 QTDIKKRIQLIQFFINVAAHCHELNNFSSLTAIISALYSSPIYRLKRTWAAVPEEYKKLL 934
Query: 225 DKLAELFGETDNWTALREYLKSI-SLPCIPYLGIFLTDLVYIDIAHPAGSPHRVTKMNI- 282
++L L N+ R+ LKSI PC+P+ G++L+DL + +P +N
Sbjct: 935 EELNTLMDSAKNFIRYRQLLKSIGDFPCVPFFGVYLSDLTFTANGNPDFLHRNTVLVNFG 994
Query: 283 -------VLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEPPS 335
+LK + YQ S Y++ + F+ S +E L + QY SL+ EP +
Sbjct: 995 KRVRILEILKEISVYQRSHYKLKRYEDIQAFIES--SLENLPSI--EKQYAQSLRNEPRT 1050
Query: 336 PVGS 339
V +
Sbjct: 1051 EVST 1054
>UniRef50_Q7S0V9 Cluster: Putative uncharacterized protein NCU09758.1;
n=1; Neurospora crassa|Rep: Putative uncharacterized
protein NCU09758.1 - Neurospora crassa
Length = 1191
Score = 113 bits (273), Expect = 9e-24
Identities = 66/174 (37%), Positives = 91/174 (52%), Gaps = 1/174 (0%)
Query: 98 SALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFW 157
S + P ++ Q+T+ + F +I P+EL WTK NK APNV A + +S
Sbjct: 907 SIMDFDPLEIARQITIKQIGLFCSITPKELLGSKWTK-NKGVGAPNVKAMSTFTTGLSNL 965
Query: 158 TVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLS 217
V IL K RA I+ H+IK+ + LNN L AV AL+ +SI RL TW +S
Sbjct: 966 VVDTILQFDEIKKRAAIIKHWIKIGSQFLALNNYDGLMAVTCALNDSSIKRLRMTWDTIS 1025
Query: 218 KKDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPA 271
+ K+ L + N ALR L PC+PY+G+FLTDL +ID +PA
Sbjct: 1026 SRRKETLKSLQAIVEIGQNHKALRARLAEQVPPCLPYVGMFLTDLTFIDAGNPA 1079
>UniRef50_P26675 Cluster: Protein son of sevenless; n=6;
Endopterygota|Rep: Protein son of sevenless - Drosophila
melanogaster (Fruit fly)
Length = 1596
Score = 113 bits (273), Expect = 9e-24
Identities = 68/242 (28%), Positives = 129/242 (53%), Gaps = 10/242 (4%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTV 159
L L P ++ QLTLL+ +K +KP EL WTK +K +PN++ K V+ W
Sbjct: 826 LTLHPLELARQLTLLEFEMYKNVKPSELVGSPWTKKDKEVKSPNLLKIMKHTTNVTRWIE 885
Query: 160 QEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKK 219
+ I ++ + R IM I+V + ELNN + + ++++A+ +AS+YRL T+ L ++
Sbjct: 886 KSITEAENYEERLAIMQRAIEVMMVMLELNNFNGILSIVAAMGTASVYRLRWTFQGLPER 945
Query: 220 DKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHP---AGSP-- 274
++ ++ EL D+ +E L+SI+ PC+P+ G +LT++++++ +P A +
Sbjct: 946 YRKFLEECREL--SDDHLKKYQERLRSINPPCVPFFGRYLTNILHLEEGNPDLLANTELI 1003
Query: 275 --HRVTKMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEEL-QKFVEDDQYKLSLKL 331
+ K+ ++ +++YQ+ Y + + F + L K + D Y SL++
Sbjct: 1004 NFSKRRKVAEIIGEIQQYQNQPYCLNEESTIRQFFEQLDPFNGLSDKQMSDYLYNESLRI 1063
Query: 332 EP 333
EP
Sbjct: 1064 EP 1065
>UniRef50_Q55FD8 Cluster: RasGEF domain-containing protein; n=2;
Eukaryota|Rep: RasGEF domain-containing protein -
Dictyostelium discoideum AX4
Length = 1982
Score = 113 bits (272), Expect = 1e-23
Identities = 78/272 (28%), Positives = 125/272 (45%), Gaps = 16/272 (5%)
Query: 67 SNRQHDSIFHYKTNSLPAACSINQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEE 126
S + + SI LP C I + D V A + ++ QL+LL P + I+ E
Sbjct: 1713 STKSYSSILPIVIGELPK-CKIPKIIDSYVTFA-DMDEIEIARQLSLLTFPLYSRIETSE 1770
Query: 127 LTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLH 186
L W+K PN+++ FN++S W I+N + RA + +K+A +
Sbjct: 1771 LLNQRWSKPGG---GPNIMSVVGLFNKISNWVSFTIVNQPKLRDRAVVYGKMVKIANAFY 1827
Query: 187 ELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKS 246
EL N H L A+IS L+++ + RL T LSK K D L EL + R L +
Sbjct: 1828 ELRNYHLLMAIISGLNASPVLRLKYTKGKLSKNLKDNLDTLEELMSTQSSMKNYRADLAA 1887
Query: 247 ISLPCIPYLGIFLTDLVYIDIAHPAGSPHRVT--KMNIVLK---ALERYQSSEYEIAPLP 301
S P IP++G L+DLV+ID + R+ K+ + K L+ + Y+ P+P
Sbjct: 1888 ASPPAIPFMGFHLSDLVFIDEGNQQLCDSRINFKKLEMYKKTIATLQNFSLFPYQFTPVP 1947
Query: 302 HVANFLNSVRYIEELQKFVEDDQYKLSLKLEP 333
+ N+ + + + Y++SL EP
Sbjct: 1948 IIQNYFLDYKIV------ADKPIYEMSLSAEP 1973
>UniRef50_P04821 Cluster: Cell division control protein 25; n=2;
Saccharomyces cerevisiae|Rep: Cell division control
protein 25 - Saccharomyces cerevisiae (Baker's yeast)
Length = 1589
Score = 113 bits (272), Expect = 1e-23
Identities = 79/288 (27%), Positives = 145/288 (50%), Gaps = 19/288 (6%)
Query: 67 SNRQHDSIFHYKTNSLPAACSINQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEE 126
+ R + S H ++SLP++ S + + L + P QLT+L+ + I E
Sbjct: 1270 TKRDNKSPIHMSSSSLPSSAS-SAFFRLKKLKLLDIDPYTYATQLTVLEHDLYLRITMFE 1328
Query: 127 LTTCGW-TKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKL 185
W TK + +PN+ F N ++ + I+ K R+++ +F+ VA+
Sbjct: 1329 CLDRAWGTKYCNMGGSPNITKFIANANTLTNFVSHTIVKQADVKTRSKLTQYFVTVAQHC 1388
Query: 186 HELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLK 245
ELNN S+ A++SAL+S+ IYRL KTW +S + K L L N+ RE L+
Sbjct: 1389 KELNNFSSMTAIVSALYSSPIYRLKKTWDLVSTESKDLLKNLNNLMDSKRNFVKYRELLR 1448
Query: 246 SIS-LPCIPYLGIFLTDLVYIDIAHP---AGSPHRV-----TKMNIVLKALERYQSSEYE 296
S++ + C+P+ G++L+DL + + +P S + + TK+ +++ + ++ Y+
Sbjct: 1449 SVTDVACVPFFGVYLSDLTFTFVGNPDFLHNSTNIINFSKRTKIANIVEEIISFKRFHYK 1508
Query: 297 IAPLPHVANFLN-SVRYIEELQKFVEDDQYKLSLKLEPPSPVGSCAGS 343
+ L + + S+ + ++K QY+LSL++EP S G+ GS
Sbjct: 1509 LKRLDDIQTVIEASLENVPHIEK-----QYQLSLQVEPRS--GNTKGS 1549
>UniRef50_Q55GH9 Cluster: RasGEF domain-containing protein; n=1;
Dictyostelium discoideum AX4|Rep: RasGEF
domain-containing protein - Dictyostelium discoideum AX4
Length = 1172
Score = 113 bits (271), Expect = 2e-23
Identities = 56/166 (33%), Positives = 88/166 (53%), Gaps = 1/166 (0%)
Query: 106 DVGNQLTLLDLPCFKAIKPEELTTCGWT-KLNKLTVAPNVVAFTKRFNRVSFWTVQEILN 164
D+ Q+TL++ FK IK +E WT K K ++PN+V F + FN VSFW I+
Sbjct: 941 DIAIQITLMEFDLFKNIKSKEFLNLAWTHKTEKTRLSPNIVRFIEHFNSVSFWLQTCIVK 1000
Query: 165 GQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQF 224
K R ++ I +A +LNN + V+S+L S+++ RL KTW + + Q
Sbjct: 1001 SGKIKERVAVLKKVIALADVFVQLNNYYGAMEVLSSLESSAVSRLHKTWEQVPQSSIQSL 1060
Query: 225 DKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHP 270
L +L +N+ RE + CIPY+G++L+DL +I +P
Sbjct: 1061 QSLQKLLSPQENFKNYRERISKCGSCCIPYIGLYLSDLTFIHEGNP 1106
>UniRef50_Q9USU1 Cluster: Exchange factor Cdc25p-like; n=1;
Schizosaccharomyces pombe|Rep: Exchange factor
Cdc25p-like - Schizosaccharomyces pombe (Fission yeast)
Length = 987
Score = 113 bits (271), Expect = 2e-23
Identities = 71/242 (29%), Positives = 125/242 (51%), Gaps = 16/242 (6%)
Query: 103 SPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEI 162
+P++ +Q+TLL+ K I E W + + N + F+ F ++W + I
Sbjct: 752 TPEEFASQMTLLEFDYLKQIPSREWIFRSWVSRDSRSAVRNYINFSNCF---TYWIINCI 808
Query: 163 LNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQ 222
L ++ KAR +++ FI+ A K L N +L +++SAL+SA IYRL + + +D
Sbjct: 809 LEKKNTKARTAVISFFIQTAYKCLSLQNFSTLMSIVSALNSAPIYRLHAAYKLVKAEDII 868
Query: 223 QFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHP---AGSPHRVT- 278
L E+ N++ R L+ LPC+P+LG+ L+DL +ID +P SPH ++
Sbjct: 869 CLSGLREIVETKKNFSTYRALLRKAELPCVPFLGVILSDLTFIDEGNPDVLDSSPHLLSF 928
Query: 279 ----KMNIVLKALERYQSSEYEIAPLPHVANF-LNSVRYIEELQKFVEDDQYKLSLKLEP 333
++ V+ + R+QSS YE+ + ++ L+ R++ + ++ D SL LEP
Sbjct: 929 NKRHRLADVVADVCRFQSSSYEMQSNTDLQSYILHRCRFVNQDLSYLFDK----SLSLEP 984
Query: 334 PS 335
S
Sbjct: 985 RS 986
>UniRef50_Q4WNQ3 Cluster: Ras guanine-nucleotide exchange protein,
putative; n=5; Trichocomaceae|Rep: Ras guanine-nucleotide
exchange protein, putative - Aspergillus fumigatus
(Sartorya fumigata)
Length = 1167
Score = 112 bits (270), Expect = 2e-23
Identities = 60/169 (35%), Positives = 95/169 (56%), Gaps = 1/169 (0%)
Query: 98 SALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFW 157
S L P ++ QLT+ + F AI PEEL W K ++A NV A + ++
Sbjct: 876 SILDFDPLELARQLTIKESRIFCAILPEELLATEWMK-KSASLAVNVRAMSTLSTDLAHL 934
Query: 158 TVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLS 217
IL + PK RA I+ ++K+A K ELNN +L A+I +L+S+ I RL +TW +S
Sbjct: 935 VADSILQLEEPKKRAAIIKQWVKIANKCLELNNYDTLMAIICSLNSSMISRLKRTWEVVS 994
Query: 218 KKDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYID 266
+K K + L + + N+ LR+ L++ PC+P++G +LTDL ++D
Sbjct: 995 QKTKATLETLRGIVDVSRNYAVLRQRLQTHVPPCLPFVGTYLTDLTFVD 1043
>UniRef50_Q8MVR0 Cluster: Cyclic GMP-binding protein D; n=2;
Dictyostelium discoideum|Rep: Cyclic GMP-binding protein
D - Dictyostelium discoideum (Slime mold)
Length = 1312
Score = 111 bits (268), Expect = 4e-23
Identities = 72/239 (30%), Positives = 118/239 (49%), Gaps = 16/239 (6%)
Query: 39 STIPLNSQQ---SFTKDDCACYYNYGHGENGSNRQH-DSIFHYKTNSLPAACSINQSWDD 94
ST L +QQ S DD + N + N +N + + I P+ IN
Sbjct: 289 STNSLFNQQPSLSMLNDDGSVQNNNNNNNNNNNNNNVNEISTINVQLPPSTPPIN----G 344
Query: 95 IVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRV 154
I P+ + +LT+++ A+ ++T+ W K + N+ T FNR+
Sbjct: 345 IPGEKTAFLPEAIAKELTIMEWELITALSVSDITSKEWNK------SVNIQNLTTWFNRI 398
Query: 155 SFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWA 214
S W +I++ ++P+ RA I+ FI +A EL N + + ++ +LH +SI RL +WA
Sbjct: 399 SSWVSTKIISKETPEERAIIIEAFINIANFAKELKNYNCVMEILGSLHGSSISRLKSSWA 458
Query: 215 CLSKKDKQQFDKLAELFGETDNWTALREYLKSI--SLPCIPYLGIFLTDLVYIDIAHPA 271
LS+K F L L N+ R+ L ++ + PCIPYLG+FLTD Y+D ++P+
Sbjct: 459 LLSQKTNDMFQILNNLMTTDGNFKNYRKILTTVLPNEPCIPYLGLFLTDYTYLDESNPS 517
>UniRef50_Q54RZ8 Cluster: RasGEF; n=2; Dictyostelium discoideum|Rep:
RasGEF - Dictyostelium discoideum AX4
Length = 1457
Score = 111 bits (268), Expect = 4e-23
Identities = 82/265 (30%), Positives = 132/265 (49%), Gaps = 12/265 (4%)
Query: 59 NYGHGENGSNRQHDSIFHYKTNSLPAACSINQSWDDIVCSALRLSPDDVGNQLTLLDLPC 118
N + N +N +++ + TNS + Q I + L P +V LT++D
Sbjct: 1190 NNNNNNNNNNNNNNNNNNNLTNSTIKL--VVQPPIPINFNLLDSQPIEVAQTLTIMDHHY 1247
Query: 119 FKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNGQSPKARAEIMAHF 178
F I E W K NK +PN+ T FNR S V EIL ++ K R+ + +F
Sbjct: 1248 FAMIDKREFLGQRWAK-NK---SPNIQISTDHFNRTSQVVVTEILKSKNSKQRSATLGYF 1303
Query: 179 IKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFDKLAELFGETDNWT 238
I VA ELNNL ++I L+SASI RL K+W+ L K+ F+ L ++ N+
Sbjct: 1304 ISVAYCCFELNNLSGTASIIYGLNSASIQRLKKSWSKLPKESMIAFEYLDKIVTPMKNYI 1363
Query: 239 ALREYLKSISLPCIPYLGIFLTDLVYIDIAHPA--G---SPHRVTKMNIVLKALERYQSS 293
+LR + +I PC+P+LG +L DL +I+ +P+ G + ++ K+ V+ ++++Q
Sbjct: 1364 SLRHLMTTIQPPCVPFLGTYLKDLTFIEEGNPSIIGGLINFYKQRKIAEVIFQIQQHQQV 1423
Query: 294 EYE-IAPLPHVANFLNSVRYIEELQ 317
Y I P + FL S ++ Q
Sbjct: 1424 VYSAIRSNPTIKAFLMSSHTFDDKQ 1448
>UniRef50_Q5JUE6 Cluster: Rap guanine nucleotide exchange factor (GEF)
1; n=12; Euteleostomi|Rep: Rap guanine nucleotide
exchange factor (GEF) 1 - Homo sapiens (Human)
Length = 1023
Score = 111 bits (268), Expect = 4e-23
Identities = 72/234 (30%), Positives = 118/234 (50%), Gaps = 19/234 (8%)
Query: 106 DVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNG 165
++ QLTLLD F I+ E+ W K +PN+ FT+ FN +S+W I+
Sbjct: 789 EIAEQLTLLDAELFYKIEIPEVLL--WAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQ 846
Query: 166 QSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFD 225
+ + R ++ FIK+ K L +LNN +S A++SAL SA I RL W K+ +
Sbjct: 847 EKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRL--EW---QKQTSEGLA 901
Query: 226 KLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHP------AGSPHRVTK 279
+ L + ++ A R L + PCIPYLG+ L DL ++ + +P R +
Sbjct: 902 EYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRWQQ 961
Query: 280 MNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEP 333
NI L ++ +Q + Y++ + NF N + + L E+ ++LSLK++P
Sbjct: 962 FNI-LDSMRCFQQAHYDMRRNDDIINFFND--FSDHL---AEEALWELSLKIKP 1009
>UniRef50_Q13905 Cluster: Rap guanine nucleotide exchange factor 1;
n=26; Tetrapoda|Rep: Rap guanine nucleotide exchange
factor 1 - Homo sapiens (Human)
Length = 1077
Score = 111 bits (268), Expect = 4e-23
Identities = 72/234 (30%), Positives = 118/234 (50%), Gaps = 19/234 (8%)
Query: 106 DVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNG 165
++ QLTLLD F I+ E+ W K +PN+ FT+ FN +S+W I+
Sbjct: 843 EIAEQLTLLDAELFYKIEIPEVLL--WAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQ 900
Query: 166 QSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFD 225
+ + R ++ FIK+ K L +LNN +S A++SAL SA I RL W K+ +
Sbjct: 901 EKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRL--EW---QKQTSEGLA 955
Query: 226 KLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHP------AGSPHRVTK 279
+ L + ++ A R L + PCIPYLG+ L DL ++ + +P R +
Sbjct: 956 EYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRWQQ 1015
Query: 280 MNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEP 333
NI L ++ +Q + Y++ + NF N + + L E+ ++LSLK++P
Sbjct: 1016 FNI-LDSMRCFQQAHYDMRRNDDIINFFND--FSDHL---AEEALWELSLKIKP 1063
>UniRef50_Q6C637 Cluster: YlCDC25 protein; n=2; Yarrowia
lipolytica|Rep: YlCDC25 protein - Yarrowia lipolytica
(Candida lipolytica)
Length = 1250
Score = 111 bits (267), Expect = 5e-23
Identities = 62/163 (38%), Positives = 90/163 (55%), Gaps = 2/163 (1%)
Query: 106 DVGNQLTLLDLPCFKAIKPEELTTCGW-TKLNKLTVAPNVVAFTKRFNRVSFWTVQEIL- 163
D+ QLTL+D F IK EE + +K KL A N+ A T N++S IL
Sbjct: 1002 DIARQLTLIDNELFCKIKTEEFMDLNFASKKRKLGNAQNIGAMTLNTNKLSALVGDSILR 1061
Query: 164 NGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQ 223
+G + K R I+ +I++ K EL N +SL ++SAL S SI RL KTW LS + +
Sbjct: 1062 HGLNAKQRKNILKQWIRIGDKCLELGNFNSLLTIVSALQSVSIMRLRKTWEMLSPRYQTL 1121
Query: 224 FDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYID 266
F L + N+ A R ++ +PC+PYLG++LTDL +I+
Sbjct: 1122 FASLKAIVLPEKNFVAYRSRIRQQDIPCVPYLGVYLTDLTFIE 1164
>UniRef50_Q5K7Q6 Cluster: Putative uncharacterized protein; n=1;
Filobasidiella neoformans|Rep: Putative uncharacterized
protein - Cryptococcus neoformans (Filobasidiella
neoformans)
Length = 1437
Score = 111 bits (267), Expect = 5e-23
Identities = 61/169 (36%), Positives = 92/169 (54%), Gaps = 6/169 (3%)
Query: 106 DVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNG 165
++ QLT++ F+ ++PEEL G K TV P + A + N+V+ W ILN
Sbjct: 1196 ELARQLTIIVSKMFRQLEPEELLMTG-----KKTV-PELKALSTHSNQVTGWVADSILNE 1249
Query: 166 QSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFD 225
K RA ++ FIK+A K +NN ++FAV+ L+S++I RL KTW LS K K +
Sbjct: 1250 GDAKRRAGLLKFFIKLADKCLLINNFFTMFAVLGGLNSSTILRLKKTWDALSVKYKILIE 1309
Query: 226 KLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSP 274
+L + T N A R L+ PC+P+LG+ LTD+ + +P P
Sbjct: 1310 RLRGIIEHTKNHAAYRARLRQAPTPCLPFLGLILTDITFTSDGNPTTRP 1358
>UniRef50_Q7JTG3 Cluster: Nucleotide exchange factor RasGEF L; n=4;
Dictyostelium discoideum|Rep: Nucleotide exchange factor
RasGEF L - Dictyostelium discoideum (Slime mold)
Length = 2356
Score = 111 bits (266), Expect = 6e-23
Identities = 75/265 (28%), Positives = 126/265 (47%), Gaps = 10/265 (3%)
Query: 81 SLPAACSINQSWDDIVCSALRLSPDD--VGNQLTLLDLPCFKAIKPEELTTCGWTKLNKL 138
++P A NQ + L D+ V QLTL + FK I+ E W K
Sbjct: 2088 AMPEAARPNQLTTKLPSLTSSLLDDELFVAQQLTLREYETFKRIQAVEFLGQAWGKPKLQ 2147
Query: 139 TVAPNVVAFTKRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVI 198
APN++ +RFN++S IL+ K R +++ FIK+A+ +LNN H L A +
Sbjct: 2148 YKAPNLLKMIERFNKISTGVSTAILSQPKIKTRVKLICRFIKIAQHCRDLNNYHLLTAFM 2207
Query: 199 SALHSASIYRLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIF 258
+ + ++++ RL +WA + KK + L ++ ++ R + PCIPYLG++
Sbjct: 2208 AGIRNSNVVRLRLSWAKVPKKHLHILEDLEKIMSMEGSFKEFRTKMAETIPPCIPYLGVY 2267
Query: 259 LTDLVYIDIAHPAGSPHRVT--KMNI---VLKALERYQSSEYEIA--PLPHVANFLNSV- 310
L DL +I+ +P + K + ++ ++R Q Y+ VA + V
Sbjct: 2268 LKDLTFIEEGNPDSINSLINWGKKKLIYNIISIIQRCQQVSYDFGNQNQSQVAQKSDLVL 2327
Query: 311 RYIEELQKFVEDDQYKLSLKLEPPS 335
Y + L +++ YK+SL LEP S
Sbjct: 2328 NYFDSLPIALDELLYKISLNLEPRS 2352
>UniRef50_A4RFZ9 Cluster: Putative uncharacterized protein; n=2;
Sordariomycetes|Rep: Putative uncharacterized protein -
Magnaporthe grisea (Rice blast fungus) (Pyricularia
grisea)
Length = 1295
Score = 111 bits (266), Expect = 6e-23
Identities = 62/174 (35%), Positives = 97/174 (55%), Gaps = 1/174 (0%)
Query: 98 SALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFW 157
S L L ++ QLT+ + F +I PEEL W K N +PNV A + N +S
Sbjct: 972 SILDLDALEIARQLTIKQMNIFCSIMPEELLGSQWMK-NGGAESPNVKAMSTFSNDLSSL 1030
Query: 158 TVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLS 217
IL+ K RA ++ +IK+A + +LNN +L A+I +L+S++I RL +TW +S
Sbjct: 1031 VSDTILHYNEVKKRAAVLKQWIKIAHQCLDLNNYDALMAIICSLNSSTITRLRRTWEAVS 1090
Query: 218 KKDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPA 271
+ ++ +L + + N LR L PC+P+LG+FLTDL ++DI +PA
Sbjct: 1091 PRRRELLKQLQAIVEPSQNNKVLRGRLAGHVPPCLPFLGMFLTDLTFVDIGNPA 1144
>UniRef50_UPI0000ECA662 Cluster: Rap guanine nucleotide exchange
factor 1 (Guanine nucleotide-releasing factor 2) (C3G
protein) (CRK SH3-binding GNRP).; n=1; Gallus gallus|Rep:
Rap guanine nucleotide exchange factor 1 (Guanine
nucleotide-releasing factor 2) (C3G protein) (CRK
SH3-binding GNRP). - Gallus gallus
Length = 1230
Score = 109 bits (263), Expect = 1e-22
Identities = 70/233 (30%), Positives = 117/233 (50%), Gaps = 17/233 (7%)
Query: 106 DVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNG 165
++ QLTLLD F I+ E+ W K +PN+ FT+ FN +S+W I+
Sbjct: 996 EIAEQLTLLDAELFYKIEIPEVLL--WAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQ 1053
Query: 166 QSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFD 225
+ + R ++ FIK+ K L +LNN +S A++SAL SA I RL W K+ +
Sbjct: 1054 EKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRL--EW---QKQTSEGLA 1108
Query: 226 KLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPHRVT-----KM 280
+ L + ++ A R L + PCIPYLG+ L DL ++ + +P +V +
Sbjct: 1109 EYCTLIDSSSSFRAYRAALADVEPPCIPYLGLILQDLTFVHLGNPDYIDSKVNFSKRWQQ 1168
Query: 281 NIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEP 333
+L ++ +Q Y+I + +F N + + L E+ ++LSLK++P
Sbjct: 1169 FNILDSMRCFQQVHYDIKRNDDIVSFFND--FSDHL---AEEALWELSLKIKP 1216
>UniRef50_Q07889 Cluster: Son of sevenless homolog 1; n=70; cellular
organisms|Rep: Son of sevenless homolog 1 - Homo sapiens
(Human)
Length = 1333
Score = 108 bits (260), Expect = 3e-22
Identities = 62/247 (25%), Positives = 130/247 (52%), Gaps = 12/247 (4%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTV 159
L L P ++ QLTLL+ ++A++P EL WTK +K +PN++ + ++ W
Sbjct: 777 LTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFE 836
Query: 160 QEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKK 219
+ I+ ++ + R +++ I++ + ELNN + + V+SA++S+ +YRL T+ + +
Sbjct: 837 KCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSR 896
Query: 220 DKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPA-----GSP 274
K+ ++ EL D++ L+SI+ PC+P+ GI+LT+++ + +P G
Sbjct: 897 QKKILEEAHEL--SEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKE 954
Query: 275 ----HRVTKMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYI-EELQKFVEDDQYKLSL 329
+ K+ + +++YQ+ Y + + F ++ + ++K D + SL
Sbjct: 955 LINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSL 1014
Query: 330 KLEPPSP 336
++EP +P
Sbjct: 1015 EIEPRNP 1021
>UniRef50_UPI000049846E Cluster: Ras guanine nucleotide exchange
factor; n=1; Entamoeba histolytica HM-1:IMSS|Rep: Ras
guanine nucleotide exchange factor - Entamoeba
histolytica HM-1:IMSS
Length = 464
Score = 108 bits (259), Expect = 5e-22
Identities = 73/240 (30%), Positives = 124/240 (51%), Gaps = 12/240 (5%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQE 161
L+ + + QL+L +L F I+ ++ WTK +K P + F + FN V+ W
Sbjct: 227 LTAETIVGQLSLYELTLFTGIEMKDFLGSAWTKKDKYERCPRLCEFLEHFNAVTNWVSYS 286
Query: 162 ILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDK 221
IL ARA +++ FI VAK ++E N F S L+S++I RLTKTW L +
Sbjct: 287 ILQESDINARANLISKFIDVAKIMYEQMNFTGFFEFYSGLNSSAISRLTKTWE-LVENAA 345
Query: 222 QQFDKLAELFGETDNWTALREYL-KSISLPCIPYLGIFLTDLVYIDIAHP----AGSPH- 275
Q+ D L + T ++ + R+Y+ ++ S IP++G+ + DL +ID +P +G +
Sbjct: 346 QRMDPLRKAADPTRSYASYRKYIQQNKSKGYIPFIGVIIQDLTFIDEGNPDKTESGDVNF 405
Query: 276 -RVTKMNIVLKALERYQSSEYEI-APLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEP 333
+ M L + Q+ ++ I LP +F+ S IE+ + E QY +SL+++P
Sbjct: 406 EKCRMMANQLLTIRPLQNDQHSIYKALPFFKDFILS---IEQHKNDDEKAQYDISLQIQP 462
>UniRef50_A2RRV5 Cluster: Histone H2A; n=2; Danio rerio|Rep: Histone
H2A - Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 713
Score = 107 bits (258), Expect = 6e-22
Identities = 60/242 (24%), Positives = 128/242 (52%), Gaps = 12/242 (4%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQE 161
L P ++ QLTLL+ ++A++P EL WTK +K +PN++ + ++ W +
Sbjct: 176 LHPIEIARQLTLLESDFYRAVQPSELVGSVWTKEDKEINSPNLLRMIRHTTNLTLWLEKC 235
Query: 162 ILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDK 221
I+ ++ + R +++ I++ + ELNN + + V+SA++S+ +YRL T+ + + +
Sbjct: 236 IVETENVEERVSVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQR 295
Query: 222 QQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPHRVT--- 278
+ ++ EL D++ L+SI+ PC+P+ GI+LT+++ + +P T
Sbjct: 296 KILEEAHEL--SEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPDFLKRHGTELI 353
Query: 279 ------KMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEE-LQKFVEDDQYKLSLKL 331
K+ + +++YQ+ Y + + F ++ +E+ ++K D + SL++
Sbjct: 354 NFSKRRKVAEITGEIQQYQNQPYCLRVENDIRKFFENLNPMEDMMEKEFTDYLFNKSLEI 413
Query: 332 EP 333
EP
Sbjct: 414 EP 415
>UniRef50_Q54WL2 Cluster: RasGEF domain-containing protein; n=3;
Eukaryota|Rep: RasGEF domain-containing protein -
Dictyostelium discoideum AX4
Length = 1765
Score = 106 bits (254), Expect = 2e-21
Identities = 59/161 (36%), Positives = 89/161 (55%), Gaps = 3/161 (1%)
Query: 110 QLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNGQSPK 169
Q+TL+D F+ I EL K + ++PN + + FNR S W EILN +P
Sbjct: 1478 QITLIDEKAFRMIPIFELLK---KKFVRPDLSPNFQSMVQLFNRWSSWVGSEILNCTTPA 1534
Query: 170 ARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFDKLAE 229
+RA ++ FI++A L L N H +A+ ++ +I RL TW +SKK QF++L +
Sbjct: 1535 SRALVIEKFIEIAFILLNLKNFHCCYAITQGIYHYAIKRLYLTWDKISKKSMNQFEELQK 1594
Query: 230 LFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHP 270
+F N RE L S S P IPYLG++ DL+ I+ ++P
Sbjct: 1595 IFSTESNHKNYREVLNSSSPPLIPYLGLYTKDLLVIEDSNP 1635
>UniRef50_Q9N5D3 Cluster: Drosophila sos homolog protein 1; n=3;
Caenorhabditis|Rep: Drosophila sos homolog protein 1 -
Caenorhabditis elegans
Length = 1493
Score = 105 bits (253), Expect = 2e-21
Identities = 76/278 (27%), Positives = 128/278 (46%), Gaps = 17/278 (6%)
Query: 66 GSNRQHDSIFHYKTNSLPAACS-----INQSWDDIVCSALRLSPDDVGNQLTLLDLPCFK 120
G ++QH TN P + Q D L L P ++G QLTLL ++
Sbjct: 855 GDDQQHPPQHQVYTNESPKETNQVLWHTAQKGDVDHYDLLTLHPIEIGRQLTLLHSDLYR 914
Query: 121 AIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNGQSPKARAEIMAHFIK 180
AI+P EL WTK K +P ++ T +++W + I+ +S + R + ++
Sbjct: 915 AIQPIELVEAAWTKAEKWRKSPQLLRLTDHSTLLTYWVSRSIVETESLEERMAMFNRVLE 974
Query: 181 VAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFDKLAELFGETDNWTAL 240
V EL+N L A SAL+S+ I+RL W L + K+ FD+ L W +
Sbjct: 975 VMSVFEELHNFTGLVAFYSALNSSCIFRLKWCWDGLDNEKKKCFDRFNTLCER--RWQEM 1032
Query: 241 REYLKSISLPCIPYLGIFLTDLVYIDIAH--------PAGSPHRVTKMNIVLKALERYQS 292
++ L SI+ PCIP+ G +L+++ +++ + P G+ + LKA + ++
Sbjct: 1033 QKRLSSINPPCIPFFGHYLSNIYFLEQGNSTFVNKSPPHGAAGAQKQQKDDLKASDP-EN 1091
Query: 293 SEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLK 330
S + L I E+Q F +D +Y L+L+
Sbjct: 1092 SNKQFKQLVSFLKLRKISNVIREIQIF-QDQRYSLTLE 1128
>UniRef50_Q12967 Cluster: Ral guanine nucleotide dissociation
stimulator; n=29; Eutheria|Rep: Ral guanine nucleotide
dissociation stimulator - Homo sapiens (Human)
Length = 914
Score = 105 bits (251), Expect = 4e-21
Identities = 88/273 (32%), Positives = 129/273 (47%), Gaps = 43/273 (15%)
Query: 104 PDDVGNQLTLLDLPCFKAIKPEELTTCGWT---KLNKLTVAPNVVAFTKRFNRVSFWTVQ 160
PD V Q TL+D FK + P W+ K K +AP + A +FN V+ +
Sbjct: 387 PDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQFNSVANCVIT 446
Query: 161 EILNGQSPKA--RAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSK 218
L +S KA RA ++ H+I+VA++ L N SL+A++SAL S SI+RL KTW +S+
Sbjct: 447 TCLGNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKTWEDVSR 506
Query: 219 KDKQQFDKLAELFGETDNWTALREYL------------------------KSISLPCIPY 254
+ F KL+E+F + +N++ RE L I +PY
Sbjct: 507 DSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPKRAQKRPKETGIIQGTVPY 566
Query: 255 LGIFLTDLVYIDIAHPAGSPHRV------TKMNIVLKALERYQS--SEYEIAPLPHVANF 306
LG FLTDLV +D A R+ K V+ ++ QS + Y IAP +
Sbjct: 567 LGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNYSIAPDEQFGAW 626
Query: 307 LNSVRYIEELQKFVEDDQYKLSLKLEPPSPVGS 339
+V ++ E + Y LS +LEPPS S
Sbjct: 627 FRAV------ERLSETESYNLSCELEPPSESAS 653
>UniRef50_Q75AF6 Cluster: ADL038Wp; n=1; Eremothecium gossypii|Rep:
ADL038Wp - Ashbya gossypii (Yeast) (Eremothecium
gossypii)
Length = 1509
Score = 104 bits (250), Expect = 6e-21
Identities = 62/209 (29%), Positives = 110/209 (52%), Gaps = 15/209 (7%)
Query: 141 APNVVAFTKRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISA 200
+PN+ +F + N ++ + I+ K R +I+ +FI VA+ LNN S+ A+ SA
Sbjct: 1271 SPNISSFIQNSNHLTNYVSYMIVKQTDLKRRVQIVQYFIDVAETCRALNNFSSMTAITSA 1330
Query: 201 LHSASIYRLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSI-SLPCIPYLGIFL 259
+ S+SIYRL +TWA + K+ D++ L N+ RE L+S+ PC+P+ G++L
Sbjct: 1331 MLSSSIYRLKRTWAMVHDNYKESLDRMNALMDSAKNFRKYRELLESLGDCPCVPFFGVYL 1390
Query: 260 TDLVYIDIAHP------AGSPHRVTKMNI--VLKALERYQSSEYEIAPLPHVANFLNS-V 310
+DL + +P G + + I VLK ++ YQ Y + + + F++ +
Sbjct: 1391 SDLTFTAGGNPDYLKGTTGVINFAKRARIVNVLKEIDSYQRISYRLKRIAEIQEFIDERL 1450
Query: 311 RYIEELQKFVEDDQYKLSLKLEPPSPVGS 339
+ ++K QY+LSL++EP V +
Sbjct: 1451 LNVPNIEK-----QYELSLRIEPRQEVST 1474
>UniRef50_A7TNK1 Cluster: Putative uncharacterized protein; n=1;
Vanderwaltozyma polyspora DSM 70294|Rep: Putative
uncharacterized protein - Vanderwaltozyma polyspora DSM
70294
Length = 1302
Score = 104 bits (250), Expect = 6e-21
Identities = 76/270 (28%), Positives = 127/270 (47%), Gaps = 17/270 (6%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTV 159
L + P QLTL+D + I + W + + + ++ F N+++ +
Sbjct: 1013 LDIDPFVFATQLTLIDEKLYTKISAFDCLHRVWRDIGSSS-SKSISHFISNANKLTNFVS 1071
Query: 160 QEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKK 219
I+ K RA+++ +I VA +NN S+ A+ISAL+S+ IYRLTKTW +
Sbjct: 1072 YIIVTQPEVKKRAKLIQFWITVAIHCQAMNNFSSMTAIISALYSSPIYRLTKTWKLIGVD 1131
Query: 220 DKQQFDKLAELFGETDNWTALREYLKSI--SLPCIPYLGIFLTDLVYIDIAHPAGSPHRV 277
+ L L T N+ RE + SI S+PC+P+ G+FL+DL ++ +P R
Sbjct: 1132 HVENLKALNNLMNSTKNFLNYREKVGSINKSIPCVPFFGVFLSDLTFVASGNPDFLDPRS 1191
Query: 278 TKMNI--------VLKALERYQSSEYEIAPLPHVANFL-NSVRYIEELQKFVEDDQYKLS 328
T +N +++ + +++ Y+I V F+ N+ I ++K QY+LS
Sbjct: 1192 TIINFYKRRRVVEIIQEIIKFKQVRYKINTYEEVKEFIVNNTENIPHIEK-----QYELS 1246
Query: 329 LKLEPPSPVGSCAGSKESVKETVLQGNVTT 358
L +EP G+ SV T G T
Sbjct: 1247 LVIEPRYDGGANLSPSNSVFTTHHHGQKGT 1276
>UniRef50_UPI0000498DA7 Cluster: Ras guanine nucleotide exchange
factor; n=1; Entamoeba histolytica HM-1:IMSS|Rep: Ras
guanine nucleotide exchange factor - Entamoeba
histolytica HM-1:IMSS
Length = 677
Score = 104 bits (249), Expect = 7e-21
Identities = 67/238 (28%), Positives = 114/238 (47%), Gaps = 9/238 (3%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQE 161
L + QLTL + FK+I+ +E+ WTK +K +PN+ A FN ++ W +
Sbjct: 439 LPTEQFAQQLTLYEYELFKSIEAKEMLGNAWTKSDKTERSPNLCALIDHFNSITNWVIST 498
Query: 162 ILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDK 221
I++ + K RA I+ FI + +++ LNN + +F + S L+S + RL TW + K
Sbjct: 499 IVDESNIKQRATIIKKFISIGEEMLRLNNYNGVFEMFSGLNSTPVGRLKLTWEEVGNFSK 558
Query: 222 QQFDKLAELFGETDNWTALREYLKS-ISLPCIPYLGIFLTDLVYIDIAHPAGSPH---RV 277
+ L + T ++ A R +KS S PCIP+ G++L DL +I + + +
Sbjct: 559 -KMKALERVTIPTGSYQAYRADIKSHQSFPCIPFFGVYLQDLTFIHEGNEDKNENGDVNF 617
Query: 278 TKMNIVLKALE--RYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEP 333
K ++ K +E + YE P + F+ + E + Y SL +EP
Sbjct: 618 VKCSLTTKVIEDMLFYKRYYEYYRNPEILAFIRKIEI--RCLTMGEKELYDKSLIIEP 673
>UniRef50_Q7PSV2 Cluster: ENSANGP00000005326; n=1; Anopheles gambiae
str. PEST|Rep: ENSANGP00000005326 - Anopheles gambiae
str. PEST
Length = 1262
Score = 103 bits (246), Expect = 2e-20
Identities = 67/240 (27%), Positives = 118/240 (49%), Gaps = 18/240 (7%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTV 159
L L ++ Q+TLLD F+ I+ E+ W + +PN+ FT+ FN++S+W
Sbjct: 1026 LDLKSAEIAEQMTLLDAELFQKIEIPEVLI--WAQEQCEERSPNLTRFTEHFNKMSYWAR 1083
Query: 160 QEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKK 219
+IL+ K R + + FIK+ K L ++NN +S A++SAL SA I RL W K
Sbjct: 1084 TQILSQNDAKDREKHVIKFIKIMKHLRKINNYNSYLALLSALDSAPIRRL--EW---HKT 1138
Query: 220 DKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPHRVTK 279
+ + L + ++ A R+ L + PCIPY+G+ L DL ++ I +P P T
Sbjct: 1139 ITEGLKEYCALIDSSSSFRAYRQALAETNPPCIPYIGLVLQDLTFVHIGNPDLLPDGSTN 1198
Query: 280 MN------IVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEP 333
+ ++ ++R++ Y + F ++ Y + ED +++S ++P
Sbjct: 1199 FSKRWQQYHIVVNMKRFKKGSYPFKKNERIIGFFDNFEYYLD-----EDAMWQISETIKP 1253
>UniRef50_A7SA05 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 434
Score = 102 bits (245), Expect = 2e-20
Identities = 69/236 (29%), Positives = 115/236 (48%), Gaps = 20/236 (8%)
Query: 107 VGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNGQ 166
+ QLTL+D F AI+ E+ W K +PN+ FT+ FN+VS+W+ IL+ +
Sbjct: 211 LAEQLTLIDAQNFAAIEIPEILA--WGKEQSEGNSPNLTVFTENFNKVSYWSRSYILSFE 268
Query: 167 SPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFDK 226
P+ R + F+K+ K L NN +S A++SA+ +++ RL W K Q +
Sbjct: 269 KPQDREKAYLKFLKIMKHLRRFNNFNSFLAILSAMDCSAVRRL--DW---PKHYLDQLAE 323
Query: 227 LAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAH----PAGSPHRVTKMNI 282
EL + ++ A R L PCIPYLG+ L D+ ++ + + G + V + +
Sbjct: 324 YTELIDSSSSFRAYRAALAEAQPPCIPYLGLILQDVTFVCLGNADELADGKVNFVKRWQL 383
Query: 283 --VLKALERYQSSEYEIAPLPHVANFLNSV-RYIEELQKFVEDDQYKLSLKLEPPS 335
+L + R++ +YE + F Y+ EDD ++ SL L+P S
Sbjct: 384 FNILDTVRRFKLVQYEFEANEEIRQFFGGFNNYLN------EDDLFEKSLILKPRS 433
>UniRef50_Q6CRG2 Cluster: Kluyveromyces lactis strain NRRL Y-1140
chromosome D of strain NRRL Y- 1140 of Kluyveromyces
lactis; n=1; Kluyveromyces lactis|Rep: Kluyveromyces
lactis strain NRRL Y-1140 chromosome D of strain NRRL Y-
1140 of Kluyveromyces lactis - Kluyveromyces lactis
(Yeast) (Candida sphaerica)
Length = 1537
Score = 101 bits (243), Expect = 4e-20
Identities = 74/253 (29%), Positives = 126/253 (49%), Gaps = 16/253 (6%)
Query: 104 PDDVGNQLTLLDLPCFKAIKPEELTTCGW-TKLNKLTVAPNVVAFTKRFNRVSFWTVQEI 162
P QLTL + + AI E W K+ + N+ F N ++ + I
Sbjct: 1268 PITFAQQLTLEEHILYSAIDQFECLDRIWGKKVCDFGGSANISNFITSSNHLTDFVSYTI 1327
Query: 163 LNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQ 222
+ K RA+I+ FI+V+++ + L N S+ A++SAL+S+ I+RL KT+ L K
Sbjct: 1328 VKETDLKKRAQILQFFIQVSEQCYNLKNFSSMTAIVSALYSSPIFRLKKTFDRLPKHILN 1387
Query: 223 QFDKLAELFGETDNWTALREYLKSI-SLPCIPYLGIFLTDLVYIDIAHP---AGSPH--- 275
DKL L T N+ R+ LK++ +PC+P+ G++L+DL + +P +P+
Sbjct: 1388 SLDKLNTLMDSTRNFFRYRDLLKTVHDVPCVPFFGVYLSDLTFTASGNPDNLNNNPNLFN 1447
Query: 276 --RVTKMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVE-DDQYKLSLKLE 332
+ K+ ++L + +Q Y++ V FL + E++ + + QY+LSLK+E
Sbjct: 1448 FSKRLKIVMILNEIMSFQKITYKLKHSEEVKLFLEA-----EMENILSIEKQYELSLKIE 1502
Query: 333 PPSPVGSCAGSKE 345
P V S S E
Sbjct: 1503 PRVDVSSSFNSAE 1515
>UniRef50_A7TRY3 Cluster: Putative uncharacterized protein; n=1;
Vanderwaltozyma polyspora DSM 70294|Rep: Putative
uncharacterized protein - Vanderwaltozyma polyspora DSM
70294
Length = 1548
Score = 101 bits (243), Expect = 4e-20
Identities = 68/234 (29%), Positives = 119/234 (50%), Gaps = 16/234 (6%)
Query: 110 QLTLLDLPCFKAIKPEELTTCGW-TKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNGQSP 168
QLT+L+ F I + W +K L + N+ F N+ + + I+ Q
Sbjct: 1276 QLTILEQQLFMKISTFDCLDRIWRSKYCDLGGSENISNFISSANQFTNYVSHSIVITQDV 1335
Query: 169 KARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFDKLA 228
K RA+ + +FI VA LNN + A+ISAL+S+ +YRL KTW + K+ L
Sbjct: 1336 KKRAKRVQYFISVANHCRLLNNFSVMTAIISALYSSPVYRLKKTWQLIPKEYNDILKNLN 1395
Query: 229 ELFGETDNWTALREYLKSI-SLPCIPYLGIFLTDLVYIDIAHP---AGSPHRV-----TK 279
L T N+ R+ ++S+ +PC+P+ G+FL+DL + +P GS H + T+
Sbjct: 1396 TLMDSTKNFIKYRQLVESVKDVPCVPFFGVFLSDLTFTSDGNPDFIKGSSHIINFNKRTR 1455
Query: 280 MNIVLKALERYQSSEYEIAPLPHVANFL-NSVRYIEELQKFVEDDQYKLSLKLE 332
+ +L+ + ++ Y + P + N++ +S+ + ++K QY+LSL +E
Sbjct: 1456 IADILRDIMSFKVIHYNLKPNEEIQNYIEHSLVGVPHIEK-----QYELSLAIE 1504
>UniRef50_A2EWA8 Cluster: RasGEF domain containing protein; n=1;
Trichomonas vaginalis G3|Rep: RasGEF domain containing
protein - Trichomonas vaginalis G3
Length = 808
Score = 101 bits (241), Expect = 7e-20
Identities = 53/170 (31%), Positives = 94/170 (55%), Gaps = 1/170 (0%)
Query: 103 SPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEI 162
SP V L+ +L A+ E WTK +K +APN++ T+ FN ++ + V I
Sbjct: 570 SPLIVAEHLSYYELEILNAMPASEFIGTSWTKPDKWVLAPNIMKMTEHFNTITSYIVTCI 629
Query: 163 LNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQ 222
L+ +SP+ R E+++ +I++ ++++ +F + AL + +I RL+K+W +S+++K
Sbjct: 630 LSKESPQERGELISRWIEIMVAALDISSFQLVFEIFGALCNPAITRLSKSWDFVSQENKD 689
Query: 223 QFDKLAELFGETDNWTALREYLKSISLPC-IPYLGIFLTDLVYIDIAHPA 271
F K E + + E LKS + C IPY+G LT+LVY +P+
Sbjct: 690 NFLKAQEFTSPSRQFAIYMERLKSTPVTCAIPYIGPMLTNLVYTHDGNPS 739
>UniRef50_Q5T5Z4 Cluster: Ral GEF with PH domain and SH3 binding
motif 2; n=15; Eutheria|Rep: Ral GEF with PH domain and
SH3 binding motif 2 - Homo sapiens (Human)
Length = 223
Score = 101 bits (241), Expect = 7e-20
Identities = 64/153 (41%), Positives = 86/153 (56%), Gaps = 6/153 (3%)
Query: 276 RVTKMNIVLKAL-ERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEPP 334
R MN +L+ + + QS EY+I LPHV +LNSV+YIEELQKFVEDD YKLSLK+EP
Sbjct: 11 RSNLMNNILRIISDLQQSCEYDIPMLPHVQKYLNSVQYIEELQKFVEDDNYKLSLKIEPG 70
Query: 335 SPVGSCAGSKESVKETVLQGNVTTFNISPSHKLGSGSLRLQGTSHQGKFIP-THRKCRSL 393
+ A S+E + + + + S + G+L Q IP HRKC SL
Sbjct: 71 TSTPRSAASREDLVGPEVGASPQSGRKSVA---AEGALLPQTPPSPRNLIPHGHRKCHSL 127
Query: 394 GSNIFGKSHTEDKMDEKTP-AGSVNLLDDTLLE 425
G N K +T + P AG +LLDD+++E
Sbjct: 128 GYNFIHKMNTAEFKSATFPNAGPRHLLDDSVME 160
>UniRef50_Q3MIN7 Cluster: Ral guanine nucleotide dissociation
stimulator-like 3; n=13; Theria|Rep: Ral guanine
nucleotide dissociation stimulator-like 3 - Homo sapiens
(Human)
Length = 710
Score = 100 bits (239), Expect = 1e-19
Identities = 85/277 (30%), Positives = 131/277 (47%), Gaps = 41/277 (14%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVA---PNVVAFTKRFNRVSF 156
L S D+V QLTL+DL F ++ E W++ ++ A P V A +FN V+
Sbjct: 244 LDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTG 303
Query: 157 WTVQEILN--GQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWA 214
+ +L G + RA+ + +I++A++ EL N SL A++SAL S IYRL ++W
Sbjct: 304 CVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWG 363
Query: 215 CLSKKDKQQFDKLAELFGETDNWTALREYL--------------KSISLPC------IPY 254
+S++ F KL+++F + +N + RE L SLP +PY
Sbjct: 364 AVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPY 423
Query: 255 LGIFLTDLVYIDIAHP---AGSPHRVTKMNIVLKALERYQS-----SEYEIAPLPHVANF 306
LG FLTDLV +D A P G K + L R Q Y ++P P +
Sbjct: 424 LGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAA 483
Query: 307 LNSVRYIEELQKFVEDDQYKLSLKLEPPSPVGSCAGS 343
L++ + E+ Y+LS +EPP+ SC S
Sbjct: 484 LHA------QNQLTEEQSYRLSRVIEPPA--ASCPSS 512
>UniRef50_UPI00004996A3 Cluster: Ras guanine nucleotide exchange
factor; n=1; Entamoeba histolytica HM-1:IMSS|Rep: Ras
guanine nucleotide exchange factor - Entamoeba
histolytica HM-1:IMSS
Length = 578
Score = 99 bits (238), Expect = 2e-19
Identities = 57/159 (35%), Positives = 86/159 (54%)
Query: 106 DVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNG 165
DV Q+TL+ F+ I +EL + WTK + T+ PN+VA + N++S+ IL+
Sbjct: 305 DVAQQITLMQFDKFRRITVDELLSQMWTKKDNKTLTPNIVAMMQLTNKISYIVQNIILSF 364
Query: 166 QSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFD 225
K R + FIKVA+ L +LNN A+++AL S++IYRL T LS++ +
Sbjct: 365 VKLKYRIFAIEFFIKVAEYLKKLNNFDGFKAILAALDSSAIYRLKDTKDGLSEESIKLLT 424
Query: 226 KLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVY 264
+ + N+ LRE PCIP+LG L DLV+
Sbjct: 425 EFQSIVNYESNFKKLREITAICEPPCIPFLGSTLGDLVF 463
>UniRef50_Q4PAN1 Cluster: Putative uncharacterized protein; n=1;
Ustilago maydis|Rep: Putative uncharacterized protein -
Ustilago maydis (Smut fungus)
Length = 1559
Score = 99 bits (238), Expect = 2e-19
Identities = 49/151 (32%), Positives = 78/151 (51%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTV 159
L + ++ QLTLL+ + +KP E WTK A ++ NR+S W
Sbjct: 1397 LEIDALEMARQLTLLESRLYNKVKPAECLGLKWTKPGNDVHAKGIMDSITTHNRISAWVA 1456
Query: 160 QEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKK 219
+ IL + K RA ++ HFI +A + LNN ++A++SAL +A I+RL +TW +S+K
Sbjct: 1457 ETILQQEDLKKRAALIKHFISIADRCRALNNFSGMWAIVSALSTAPIHRLRRTWDAVSQK 1516
Query: 220 DKQQFDKLAELFGETDNWTALREYLKSISLP 250
F+ L +L + NW RE + + P
Sbjct: 1517 YVLVFESLEQLMSASRNWANYREMIHKLKPP 1547
>UniRef50_UPI00015B5730 Cluster: PREDICTED: similar to
guanine-nucleotide exchange factor c3g; n=1; Nasonia
vitripennis|Rep: PREDICTED: similar to guanine-nucleotide
exchange factor c3g - Nasonia vitripennis
Length = 1238
Score = 98.7 bits (235), Expect = 4e-19
Identities = 67/222 (30%), Positives = 107/222 (48%), Gaps = 18/222 (8%)
Query: 98 SALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFW 157
S L + + Q+TLLD F I+ E+ W + +PN+ FT+ FN++S+W
Sbjct: 996 SLLDFKSEQIAEQMTLLDAELFMKIEIPEVLV--WAQEQNEERSPNLTRFTEHFNKMSYW 1053
Query: 158 TVQEILNGQ---SPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWA 214
IL + K R + + FIK+ K L ++NN +S A++SAL SA I RL W
Sbjct: 1054 ARSRILEHRMENEAKDREKYVVKFIKIMKHLRKINNFNSYLALLSALDSAPIRRL--EW- 1110
Query: 215 CLSKKDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAH----P 270
K + + L + ++ A R+ L PCIPY+G+ L DL ++ I + P
Sbjct: 1111 --QKHITEGLKEYCALIDSSSSFRAYRQALAETQPPCIPYIGLVLQDLTFVHIGNSDLLP 1168
Query: 271 AGS---PHRVTKMNIVLKALERYQSSEYEIAPLPHVANFLNS 309
GS R + NIV + ++R++ Y + F N+
Sbjct: 1169 DGSINFSKRWQQFNIV-ENMKRFKKGTYSFKKNERIITFFNN 1209
>UniRef50_Q4T188 Cluster: Chromosome undetermined SCAF10698, whole
genome shotgun sequence; n=2; Tetraodontidae|Rep:
Chromosome undetermined SCAF10698, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 1407
Score = 98.7 bits (235), Expect = 4e-19
Identities = 56/210 (26%), Positives = 109/210 (51%), Gaps = 5/210 (2%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTV 159
+ L P ++ QLTLL+ F+A++P EL WTK +K +PN++ + ++ W
Sbjct: 829 MTLHPIEIARQLTLLESDFFRAVQPSELVGSVWTKEDKELHSPNLLRMIRHTTNLTLWFE 888
Query: 160 QEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKK 219
+ I+ ++ + R +++ I++ + ELNN + L V+SA++S+ +YRL T+ L+ +
Sbjct: 889 KCIVETENLEERVAVVSRIIEILQVFQELNNFNGLLEVVSAMNSSPVYRLDHTFEQLTSR 948
Query: 220 DKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDL-VYIDIAHPAGSPHRVT 278
++ ++ EL D++ L+SI+ PC+P+ G L L + P S H
Sbjct: 949 QRKILEEAHEL--SEDHYKKYLAKLRSINPPCVPFFGALLGSLRLRTGNRFPQSSRHLCV 1006
Query: 279 KMNIVLKALERYQ--SSEYEIAPLPHVANF 306
I L + + + + ++ + H+ NF
Sbjct: 1007 SSGIYLTNILKTEEGNPDFLLRHGKHLINF 1036
>UniRef50_UPI0000519C35 Cluster: PREDICTED: similar to C3G CG3126-PA,
isoform A; n=2; Apis mellifera|Rep: PREDICTED: similar to
C3G CG3126-PA, isoform A - Apis mellifera
Length = 1176
Score = 98.3 bits (234), Expect = 5e-19
Identities = 67/222 (30%), Positives = 107/222 (48%), Gaps = 18/222 (8%)
Query: 98 SALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFW 157
S L + + Q+TLLD F I+ E+ W + +PN+ FT+ FN++S+W
Sbjct: 934 SLLDFKSEQIAEQMTLLDADLFMKIEIPEVLI--WAQEQNEERSPNLTRFTEHFNKMSYW 991
Query: 158 TVQEILNGQ---SPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWA 214
IL + K R + + FIK+ K L ++NN +S A++SAL SA I RL W
Sbjct: 992 ARSRILEHRLENEAKDREKYVVKFIKIMKHLRKINNFNSYLALLSALDSAPIRRL--EW- 1048
Query: 215 CLSKKDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAH----P 270
K + + L + ++ A R+ L PCIPY+G+ L DL ++ I + P
Sbjct: 1049 --QKHITEGLKEYCALIDSSSSFRAYRQALAETQPPCIPYIGLVLQDLTFVHIGNSDLLP 1106
Query: 271 AGS---PHRVTKMNIVLKALERYQSSEYEIAPLPHVANFLNS 309
GS R + NIV + ++R++ Y + F N+
Sbjct: 1107 DGSINFSKRWQQFNIV-ENMKRFKKGTYSFKKHERIITFFNN 1147
>UniRef50_A2QFY6 Cluster: Contig An03c0040, complete genome; n=2;
Aspergillus|Rep: Contig An03c0040, complete genome -
Aspergillus niger
Length = 587
Score = 98.3 bits (234), Expect = 5e-19
Identities = 73/266 (27%), Positives = 123/266 (46%), Gaps = 37/266 (13%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRF-------- 151
L L P ++ QLT+++ F IKP E W K K T P V ++R
Sbjct: 282 LDLDPMELARQLTIIESRLFARIKPTECLNKSWQK--KDTDRPPSVPASRRTSTSTTSST 339
Query: 152 ----------------NRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLF 195
N+++ W + IL K R ++ + +A L+N ++
Sbjct: 340 SSIERTTGVNATILHSNQLANWVGEMILAQDEMKKRVSLIKQIVNIADNCRSLSNFATMM 399
Query: 196 AVISALHSASIYRLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYL 255
++IS L ++ IYRL +TW ++ K ++ + + L N+ R+ L S PCIP+L
Sbjct: 400 SLISGLATSPIYRLHRTWTQVNPKTRKLLEDMQSLMSSEKNFIKYRDKLHGASPPCIPFL 459
Query: 256 GIFLTDLVYIDIAHPAGSP--------HRVTKMNIVLKALERYQSSEYEIAPLPHVANFL 307
G +LTDL +I+ P+ +P + K+ +L+ +E Q+ Y + P+P + F+
Sbjct: 460 GTYLTDLTFIEDGIPSHTPPPNVMINFSKRVKVAEILREIESCQAVGYSLLPVPEIQEFI 519
Query: 308 NSVRYIEELQKFVEDDQYKLSLKLEP 333
VR ++ VE Y+ SL LEP
Sbjct: 520 --VRNVQAAGGDVE-GMYERSLALEP 542
>UniRef50_A2EJW8 Cluster: RasGEF domain containing protein; n=1;
Trichomonas vaginalis G3|Rep: RasGEF domain containing
protein - Trichomonas vaginalis G3
Length = 583
Score = 97.9 bits (233), Expect = 6e-19
Identities = 62/237 (26%), Positives = 108/237 (45%), Gaps = 9/237 (3%)
Query: 87 SINQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVA 146
+I W+D + L ++ QLT+ + AI+ EL C W K APNVVA
Sbjct: 321 NIQGLWNDNF-DIIDLPASELARQLTVWSYTRYYAIQRTELLDCAWEKPRLKHRAPNVVA 379
Query: 147 FTKRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASI 206
T FN VS W +I+ K R + +++FI V L++ N A++ L ++
Sbjct: 380 LTTHFNLVSQWAASKIIESNLTKKRLDTLSYFINVLNILYDTKNYLDAMAILGGLDHNAL 439
Query: 207 YRLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSI---SLPCIPYLGIFLTDLV 263
YR+ ++ L + D+ +K+ + F + LR P +PY+G+ L+DL
Sbjct: 440 YRMKVHFSLLPQSDRDTLEKIRDKFSPDKQFAKLRSLFDEAIENKEPALPYIGVLLSDLF 499
Query: 264 YIDIA-----HPAGSPHRVTKMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEE 315
D A + + +V K+ ++ +E + + +Y P+ V L+ I+E
Sbjct: 500 KFDDATQPFINGLINVRKVMKVYSMIYKIECFSNYKYMYLPIDQVQEKLSKFEPIDE 556
>UniRef50_Q6FVA6 Cluster: Candida glabrata strain CBS138 chromosome E
complete sequence; n=1; Candida glabrata|Rep: Candida
glabrata strain CBS138 chromosome E complete sequence -
Candida glabrata (Yeast) (Torulopsis glabrata)
Length = 1564
Score = 97.9 bits (233), Expect = 6e-19
Identities = 74/282 (26%), Positives = 132/282 (46%), Gaps = 18/282 (6%)
Query: 63 GENGSNRQHDSIFHYKTNSLPAACSINQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAI 122
GEN N K N A ++ S L + P QLTL++ + I
Sbjct: 1241 GENPLNSLQSVGLPTKNNVEQTAVKLHSSMKS--SDLLDIDPYLYAAQLTLIEHDLYLRI 1298
Query: 123 KPEELTTCGW-TKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNGQSPKARAEIMAHFIKV 181
E W K + +PN+ F N ++ + I+ + RA+++ +FI V
Sbjct: 1299 TMFECLDRAWGNKYCDMGGSPNITRFIANANSLTNYVSFTIVKHADVQKRAKLIQYFITV 1358
Query: 182 AKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFDKLAELFGETDNWTALR 241
A+ ELNN S+ A++SAL+S+ IYRL +TW + + K+ D L L N+ R
Sbjct: 1359 AQHCKELNNFSSMTAIVSALYSSPIYRLKQTWNLVPTETKEVLDNLNSLMDSKRNFIKYR 1418
Query: 242 EYLKSI-SLPCIPYLGIFLTDLV--------YIDIAHPAGSPHRVTKMNIVLKALERYQS 292
E L+S+ + C+P+ G++L+DL Y+D + + +K+ +++ + ++
Sbjct: 1419 ELLRSVKDVACVPFFGVYLSDLTFTFAGNSDYLDGKTDIINFGKRSKIANIIEGILTFKK 1478
Query: 293 SEYEIAPLPHVANFL-NSVRYIEELQKFVEDDQYKLSLKLEP 333
Y++ L V + + + ++K QY+LSL++EP
Sbjct: 1479 FHYKLKRLDDVQTGIEEGLEGVPHIEK-----QYQLSLQIEP 1515
>UniRef50_UPI0000D55549 Cluster: PREDICTED: similar to CG3126-PA,
isoform A; n=1; Tribolium castaneum|Rep: PREDICTED:
similar to CG3126-PA, isoform A - Tribolium castaneum
Length = 1063
Score = 97.5 bits (232), Expect = 8e-19
Identities = 68/238 (28%), Positives = 108/238 (45%), Gaps = 14/238 (5%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTV 159
L + + Q+TLLD F I+ E+ W + +PN+ FT+ FN++S+W
Sbjct: 828 LDFKSEQIAEQMTLLDADLFMKIEIPEVLI--WAQEQNEERSPNLTRFTEHFNKMSYWAR 885
Query: 160 QEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKK 219
IL + R + FIK+ K L ++NN +S A++SAL SA I RL W K
Sbjct: 886 TRILTAEGKDVREKYFLKFIKIMKHLRKINNFNSYLALLSALDSAPIRRL--EW---QKH 940
Query: 220 DKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPHRVTK 279
++ + L + ++ A R L PCIPY+G+ L DL ++ I + P
Sbjct: 941 VQEGLKEYCALIDSSSSFRAYRVALAETQPPCIPYIGLVLQDLTFVHIGNSNLLPDGTIN 1000
Query: 280 MNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKF----VEDDQYKLSLKLEP 333
+ K ++Y E + F R I+ Q F ED ++LS ++P
Sbjct: 1001 FS---KRWQQYNIVENMKKFKKGIYTFKKQERIIQFFQNFDDFIGEDAMWQLSESIKP 1055
>UniRef50_UPI000049A2E5 Cluster: Ras guanine nucleotide exchange
factor; n=1; Entamoeba histolytica HM-1:IMSS|Rep: Ras
guanine nucleotide exchange factor - Entamoeba
histolytica HM-1:IMSS
Length = 1190
Score = 97.5 bits (232), Expect = 8e-19
Identities = 58/167 (34%), Positives = 86/167 (51%), Gaps = 2/167 (1%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTV 159
L L P + Q+TL++ FKAIKP EL W K +K +PN+ F FN ++ V
Sbjct: 256 LLLDPLMISRQITLIEWEMFKAIKPPELYA--WNKKDKEINSPNIFNFVHHFNSMNDVFV 313
Query: 160 QEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKK 219
+ +LN R I ++V LNN + + + SA ASI+RL T L +
Sbjct: 314 RLLLNAPDVSNRVSIAKQILEVGNGFIMLNNFNGVMEIASAFSKASIHRLRLTKRFLGED 373
Query: 220 DKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYID 266
FDKL E+ ++N+ LRE + +PYLG+FLTDL++ +
Sbjct: 374 GNCIFDKLEEITQNSNNFKNLRECHRKAVGATLPYLGMFLTDLLFTE 420
>UniRef50_UPI00006A1942 Cluster: Ral GEF with PH domain and SH3
binding motif 1; n=3; Tetrapoda|Rep: Ral GEF with PH
domain and SH3 binding motif 1 - Xenopus tropicalis
Length = 352
Score = 97.5 bits (232), Expect = 8e-19
Identities = 68/182 (37%), Positives = 95/182 (52%), Gaps = 13/182 (7%)
Query: 257 IFLTDLVYIDIAHPAG-----SPHRVTKMNIVLKALERYQ-SSEYE-IAPLPHVANFLNS 309
++L D++YID A+PA + R +MN +L+ + Q S Y+ + LPHV +L S
Sbjct: 1 LYLLDIIYIDSAYPASGSIMENEQRTNQMNNILRIIADLQVSCIYDHLVTLPHVQKYLKS 60
Query: 310 VRYIEELQKFVEDDQYKLSLKLEPPSPVGSCAGSKESVKETVLQGNVTTFNISPSHKLGS 369
VRYIEELQKFVEDD YKLSL++EP + SKE + F+ P+ S
Sbjct: 61 VRYIEELQKFVEDDNYKLSLRIEPGNSSPRLVSSKEDLAGPSEMTATMRFHRRPTCPDAS 120
Query: 370 GSLRLQGTSHQGKFIPTHRKCRSLGSNIFGK-SHTEDKMDEKTPAGSVNLLDDTLLESPS 428
+ L + HRK SLG+N+ + S E K +LLDD++LES S
Sbjct: 121 VATNLPTPP-----VSRHRKSHSLGNNVMCQFSVVESKSATFPSEKQRHLLDDSVLESQS 175
Query: 429 SV 430
V
Sbjct: 176 PV 177
Score = 74.9 bits (176), Expect = 5e-12
Identities = 33/97 (34%), Positives = 54/97 (55%), Gaps = 1/97 (1%)
Query: 472 LSSWQRYWLQMSGNMLFFYGAKSFKGTNRSDFRSERCKVLTLVGWIAVWADG-DAADAFQ 530
L+SW RYW+ +SG+ L ++G KS +G R ++S K ++++GW+ V D + + FQ
Sbjct: 256 LASWTRYWVTLSGSTLLYFGPKSLRGNERKHYKSTPSKKVSILGWMVVLPDDPEHPNIFQ 315
Query: 531 LINHHSGTVYKFKAGSEYAAKQWIAKIEEVTNKIVKP 567
L N G VYKF+ S + A W +++ P
Sbjct: 316 LNNPDKGNVYKFQTSSRFHAILWHKHLDDACKSTRPP 352
>UniRef50_Q19770 Cluster: Putative uncharacterized protein; n=2;
Caenorhabditis|Rep: Putative uncharacterized protein -
Caenorhabditis elegans
Length = 654
Score = 97.5 bits (232), Expect = 8e-19
Identities = 70/241 (29%), Positives = 120/241 (49%), Gaps = 8/241 (3%)
Query: 98 SALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFW 157
S ++ SP D+ L+ +D I EL + K L P + FN +S W
Sbjct: 149 SFVQASPSDISTSLSHIDYRVLSRISITELKQ--YVKDGHLRSCPMLERSISVFNNLSNW 206
Query: 158 TVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLS 217
ILN +PK RAEI+ F+ VAK L ++NN ++L +V+ + +S+ RL KT+A LS
Sbjct: 207 VQCMILNKTTPKERAEILVKFVHVAKHLRKINNFNTLMSVVGGITHSSVARLAKTYAVLS 266
Query: 218 KKDKQQFDKLAELFGETDNWTALREYLKSISLPC-IPYLGIFLTDLVYIDIAHPAGSPHR 276
K++ +L L N+ R+ L + + IP +G+ L DLV I+ + +
Sbjct: 267 NDIKKELTQLTNLLSAQHNFCEYRKALGACNKKFRIPIIGVHLKDLVAINCSGANFEKTK 326
Query: 277 V---TKMNIVLKALERYQSSEYEIAPLPHV-ANFLNSVRYIEELQKFVEDDQYKLSLKLE 332
K+ + K L + + LP + + +N+++ ++ ++ +DD Y+LSL+ E
Sbjct: 327 CISSDKLVKLSKLLSNFLVFNQKGHNLPEMNMDLINTLKVSLDI-RYNDDDIYELSLRRE 385
Query: 333 P 333
P
Sbjct: 386 P 386
>UniRef50_Q5K6X7 Cluster: Cell division control protein 25, putative;
n=2; Filobasidiella neoformans|Rep: Cell division control
protein 25, putative - Cryptococcus neoformans
(Filobasidiella neoformans)
Length = 1368
Score = 97.5 bits (232), Expect = 8e-19
Identities = 60/196 (30%), Positives = 103/196 (52%), Gaps = 2/196 (1%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEE-LTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQ 160
++P ++ QLT+L+ ++ IKP E L ++ +APNV N ++ W
Sbjct: 1075 IAPLELARQLTILEFTLYQRIKPTECLQKIYADEVQGQLLAPNVRKVILTANILAGWIAL 1134
Query: 161 EILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKD 220
IL + K RA++ H+++ A + LNN S+ A+I+ L+S+ + RL +T LS K
Sbjct: 1135 VILQHKDAKLRAQVYKHWLQTAVECRNLNNFSSVAAIIAGLNSSPVSRLRRTRELLSAKT 1194
Query: 221 KQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAG-SPHRVTK 279
+ L + + N+ +E LK+I+ PC+P+LG +LT LV+I+ + A P TK
Sbjct: 1195 LAIKEDLDKAMDSSRNFMNYKEMLKTINPPCVPFLGFYLTALVFIEDGNKAFIKPGAPTK 1254
Query: 280 MNIVLKALERYQSSEY 295
N + ++ S Y
Sbjct: 1255 GNSMPPSMSNGSLSAY 1270
>UniRef50_Q29IL8 Cluster: GA16131-PA; n=1; Drosophila
pseudoobscura|Rep: GA16131-PA - Drosophila pseudoobscura
(Fruit fly)
Length = 1196
Score = 96.7 bits (230), Expect = 1e-18
Identities = 67/242 (27%), Positives = 120/242 (49%), Gaps = 22/242 (9%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTV 159
L L D+ Q+TLLD F+ I+ E+ + + + PN+ FT+ FN++S+W
Sbjct: 961 LDLKSLDIAEQMTLLDAELFQKIEIPEVLLFAKDQCEEKS--PNLNKFTEHFNKMSYWAR 1018
Query: 160 QEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKK 219
+IL K R + + FIK+ K L ++NN +S A++SAL S I RL W K
Sbjct: 1019 SKILRLHDAKEREKHVNKFIKIMKHLRKMNNYNSYLALLSALDSGPIRRL--EW---QKS 1073
Query: 220 DKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHP-------AG 272
++ L + ++ A R+ L + PCIPY+G+ L DL ++ + +
Sbjct: 1074 ITEEVRSFCALIDSSSSFRAYRQALAETNPPCIPYIGLVLQDLTFVHVGNQDYLSKGVIN 1133
Query: 273 SPHRVTKMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFV-EDDQYKLSLKL 331
R + NI++ ++R++ Y V +R+ E + F+ E++ +++S K+
Sbjct: 1134 FSKRWQQYNIIVN-MKRFKKCAYPFRRNERV------IRFFENFKDFMGEEEMWQISEKI 1186
Query: 332 EP 333
+P
Sbjct: 1187 KP 1188
>UniRef50_Q9Y4G8 Cluster: Rap guanine nucleotide exchange factor 2;
n=29; Euteleostomi|Rep: Rap guanine nucleotide exchange
factor 2 - Homo sapiens (Human)
Length = 1499
Score = 96.7 bits (230), Expect = 1e-18
Identities = 58/170 (34%), Positives = 86/170 (50%), Gaps = 3/170 (1%)
Query: 98 SALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFW 157
S L+LS +V QL++ + F+ I+P E KL T N+ F + N+ +FW
Sbjct: 712 SLLQLSTVEVATQLSMRNFELFRNIEPTEYID-DLFKLRSKTSCANLKRFEEVINQETFW 770
Query: 158 TVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLS 217
EIL + R +I+ HFIK+A E N +S+FA+IS L+ A + RL TW L
Sbjct: 771 VASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLP 830
Query: 218 KKDKQQFDKLAELFGETDNWTALREYLKSISL--PCIPYLGIFLTDLVYI 265
K ++ F L +LF + N R L S +L P IP + DL ++
Sbjct: 831 NKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFL 880
>UniRef50_UPI00015616A3 Cluster: PREDICTED: similar to ral guanine
nucleotide dissociation stimulator; n=3; Equus
caballus|Rep: PREDICTED: similar to ral guanine
nucleotide dissociation stimulator - Equus caballus
Length = 556
Score = 96.3 bits (229), Expect = 2e-18
Identities = 80/268 (29%), Positives = 130/268 (48%), Gaps = 38/268 (14%)
Query: 98 SALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKL---TVAPNVVAFTKRFNRV 154
S + SP DV QLT +D FK ++P E W K N+ VAP V A +FNRV
Sbjct: 293 SLMAFSPRDVAEQLTAIDAEVFKNVEPSECLGSTWGKRNRPGHENVAPTVWATVVQFNRV 352
Query: 155 SFWTVQEILNGQSPKAR--AEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKT 212
+ L + AR A+++ +I+VA++ L N+ SL AV+SAL S I+RL KT
Sbjct: 353 VKCVMTSCLGDPNVTARGRAKVLERWIEVARECRALRNISSLHAVLSALQSVPIHRLKKT 412
Query: 213 WACLSKKDKQQFDKLAE----------LFGETDNWTALREYL--------KSISLP-CIP 253
W +S+K ++F KL + + + + L L + +S P +P
Sbjct: 413 WGKVSRKSYRKFKKLCDEDNSLSWELLIKKQPSKFATLLRTLQRGRKRQQQKVSAPGIVP 472
Query: 254 YLGIFLTDLVYIDIA---HPAGSP--HRVTKM--NIVLKALERYQSSE-YEIAPLPHVAN 305
+LG LTDL+ +D A + G+ H K ++++ ++ +++E Y + P
Sbjct: 473 FLGTMLTDLIMLDTAMEDYVNGNEINHEKKKKEHKVMMEIVQLQEAAENYNLEPQERFR- 531
Query: 306 FLNSVRYIEELQKFVEDDQYKLSLKLEP 333
+ ++++ ED+ Y LS LEP
Sbjct: 532 -----AWFWDMEQLSEDESYSLSFLLEP 554
>UniRef50_Q55AH0 Cluster: Ras guanine nucleotide exchange factor; n=2;
Dictyostelium discoideum|Rep: Ras guanine nucleotide
exchange factor - Dictyostelium discoideum AX4
Length = 1043
Score = 96.3 bits (229), Expect = 2e-18
Identities = 68/246 (27%), Positives = 113/246 (45%), Gaps = 21/246 (8%)
Query: 103 SPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEI 162
S + QLTL+D FK ++ EL + K +P ++ + + SFW I
Sbjct: 803 SAQSIAQQLTLIDFSIFKDLEARELLNQNFNKPKLKYKSPTIMRMISKSTQFSFWVAYVI 862
Query: 163 LNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQ 222
L + R +I F +V K L ++NN +SL + + L+ ++RL KT LS
Sbjct: 863 LMEPKKEKRIKIFEKFCEVGKYLLKMNNFNSLMGLNAGLNLTCVHRLKKTKKKLSSSAIS 922
Query: 223 QFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAH--------PA--- 271
+L +F ++ R++L ++ LPCIPYLG LTD+ +I+ + PA
Sbjct: 923 ILTELERIFSSKKSFKNYRDHLSTVQLPCIPYLGFNLTDITFIEEGNTDNISSTDPAAAN 982
Query: 272 -GSPHRVTKMNIVLKA---LERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKL 327
G K ++ +A L R+Q + Y P + FL + ++ + + Y L
Sbjct: 983 IGPLINFKKRELLYQAWADLSRFQETPYTFQPEEPLNTFLLNFPILD------DKELYDL 1036
Query: 328 SLKLEP 333
S+ LEP
Sbjct: 1037 SIALEP 1042
>UniRef50_Q54H48 Cluster: Ras guanine nucleotide exchange factor;
n=2; Dictyostelium discoideum|Rep: Ras guanine
nucleotide exchange factor - Dictyostelium discoideum
AX4
Length = 668
Score = 95.9 bits (228), Expect = 3e-18
Identities = 66/232 (28%), Positives = 115/232 (49%), Gaps = 11/232 (4%)
Query: 107 VGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNGQ 166
+ Q+T++D AI P + ++K +K +P +FN + WT EIL+ +
Sbjct: 437 IAQQITIIDNEMLMAIPPSQFLHKSFSKESK---SPQFHDMVSKFNEWARWTSSEILSKE 493
Query: 167 SPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFDK 226
R ++ FI +AK EL N ++ A++ L+ +SI RL TW LS K Q +D+
Sbjct: 494 KLVERVVTLSFFIDLAKSCVELGNYNAANAIVGGLNHSSISRLKLTWERLSTKVTQDYDR 553
Query: 227 LAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPHRV---TKMNIV 283
L LF + N+ R+ +KS IPYLG+F DL+ I+ + + + + K ++
Sbjct: 554 LLSLFDLSMNYKNYRDEIKSTKAKIIPYLGLFPKDLIAIEEGNDNFTNNNLINTEKFRLL 613
Query: 284 LKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFV--EDDQYKLSLKLEP 333
+ +++ QS + PL +Y++ + + E D + +S KLEP
Sbjct: 614 YQTIKKIQSYQ---QPLFTFKTSEPIKQYLKNISNGLSEEKDFHSISHKLEP 662
>UniRef50_Q8TEU7 Cluster: Rap guanine nucleotide exchange factor 6;
n=104; Deuterostomia|Rep: Rap guanine nucleotide exchange
factor 6 - Homo sapiens (Human)
Length = 1601
Score = 95.1 bits (226), Expect = 5e-18
Identities = 57/170 (33%), Positives = 86/170 (50%), Gaps = 3/170 (1%)
Query: 98 SALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFW 157
S L+LS +V QL++ D F+ I+P E KLN T ++ F N+ +FW
Sbjct: 855 SMLQLSTIEVATQLSMRDFDLFRNIEPTEYID-DLFKLNSKTGNTHLKRFEDIVNQETFW 913
Query: 158 TVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLS 217
EIL + R +I+ HFIK+A E N +S+FA+IS L+ AS+ RL TW L
Sbjct: 914 VASEILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLP 973
Query: 218 KKDKQQFDKLAELFGETDNWTALREYLKSISL--PCIPYLGIFLTDLVYI 265
K ++ L ++F + N R L S S+ P IP + D+ ++
Sbjct: 974 SKYEKHLQDLQDIFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFL 1023
>UniRef50_Q54GB4 Cluster: Ras guanine nucleotide exchange factor;
n=2; Dictyostelium discoideum|Rep: Ras guanine
nucleotide exchange factor - Dictyostelium discoideum
AX4
Length = 944
Score = 94.7 bits (225), Expect = 6e-18
Identities = 64/198 (32%), Positives = 104/198 (52%), Gaps = 17/198 (8%)
Query: 79 TNSLPAACSINQSWDDIVCSALRLSPDDV-----GNQLTLLDLPCFKAIKPEELTTCGWT 133
TN++P +IN I+ S+ L +D+ QLTL++ F IKP +L TC
Sbjct: 701 TNNIP---NINHFSSRILSSSKNLEFNDIDEFEIAKQLTLIEFENFGRIKPIDLLTC--V 755
Query: 134 KLNKLTVAPNVVAFTKRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHS 193
L T P++ +RF+ +S W I+ G++ K R +I+ FIK+A+ L LNN +S
Sbjct: 756 DLKHKT--PHITNIMERFHNISTWVSTTIVRGENLKNRVKIVNKFIKIAEHLKNLNNFNS 813
Query: 194 LFAVISALHSASIYRLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISLPCIP 253
L A++ A I R T T L K+ + L +L D+++ R L S PC+P
Sbjct: 814 LTAILVA-----IQRSTVTKKDLVKQSVKIITDLEKLMSSDDSYSTYRTRLAQCSPPCVP 868
Query: 254 YLGIFLTDLVYIDIAHPA 271
Y+ I+L D++ ++ +P+
Sbjct: 869 YISIYLQDIMDLEKKNPS 886
>UniRef50_Q6FVQ6 Cluster: Candida glabrata strain CBS138 chromosome D
complete sequence; n=1; Candida glabrata|Rep: Candida
glabrata strain CBS138 chromosome D complete sequence -
Candida glabrata (Yeast) (Torulopsis glabrata)
Length = 1308
Score = 94.3 bits (224), Expect = 8e-18
Identities = 66/260 (25%), Positives = 134/260 (51%), Gaps = 16/260 (6%)
Query: 98 SALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGW-TKLNKLTVAPNVVAFTKRFNRVSF 156
S L + ++V QL L++ ++ I + W K + N+ F N ++
Sbjct: 987 SILDIPAENVAQQLALIEENLYEKITIFDCLDRVWGCKQCDFGGSKNISEFISFANSITK 1046
Query: 157 WTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACL 216
+ +IL + R + + +FIKVA+ +E+NN S+ A+IS ++++ + RL ++W +
Sbjct: 1047 YVSYKILQYDTAAKRGQAIGYFIKVARISYEINNFSSMTAIISGIYASPVNRLHESWKLV 1106
Query: 217 SKKDKQQFDKLAELFGETDNWTALREYLKSI-SLPCIPYLGIFLTDLVYIDIAHP----- 270
S++ + +L +L T N+ R LK++ + PCIP+ G++L+DL++ +P
Sbjct: 1107 SRELQNTLRELDDLMISTKNFLKYRLTLKNVGNRPCIPFFGVYLSDLLFTHNGNPDYVDK 1166
Query: 271 -AGSPHRVTKMNI--VLKALERYQSSEYEI-APLPHVANFLNSVRYIEELQKFVEDDQYK 326
G+ + + I +++ + Y+ +YE A L + + +N + ++ ++QY
Sbjct: 1167 SRGTVNFTKRFRIFDIIQEIFHYKKVKYEYKADLDIIHHIMNVAENVPDV-----ENQYH 1221
Query: 327 LSLKLEPPSPVGSCAGSKES 346
LSL+LEP S S + S ++
Sbjct: 1222 LSLQLEPRSKSTSTSSSGDT 1241
>UniRef50_UPI0000E1F333 Cluster: PREDICTED: RAS guanyl releasing
protein 3 (calcium and DAG-regulated) isoform 1; n=2;
Catarrhini|Rep: PREDICTED: RAS guanyl releasing protein
3 (calcium and DAG-regulated) isoform 1 - Pan
troglodytes
Length = 555
Score = 93.9 bits (223), Expect = 1e-17
Identities = 67/238 (28%), Positives = 114/238 (47%), Gaps = 12/238 (5%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQE 161
L P ++ LT L+ F+ I + + + L P + FN +S W
Sbjct: 54 LEPIELAEHLTFLEHKSFRRISFTDYQS--YVIHGCLENNPTLERSIALFNGISKWVQLM 111
Query: 162 ILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDK 221
+L+ +P+ RAE++ FI VAKKL +L N ++L AV+ L +SI RL +T + LS +
Sbjct: 112 VLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVT 171
Query: 222 QQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPH------ 275
+ ++++ EL N+ R+ IP LG+ L DL+ + + P +
Sbjct: 172 KNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTEENKVNIV 231
Query: 276 RVTKMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEP 333
++ ++++ L L Q++ + + P + N L + EDD YKLSL LEP
Sbjct: 232 KMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYH----TEDDIYKLSLVLEP 285
>UniRef50_Q8IV61 Cluster: RAS guanyl-releasing protein 3; n=79;
Euteleostomi|Rep: RAS guanyl-releasing protein 3 - Homo
sapiens (Human)
Length = 690
Score = 93.9 bits (223), Expect = 1e-17
Identities = 67/238 (28%), Positives = 114/238 (47%), Gaps = 12/238 (5%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQE 161
L P ++ LT L+ F+ I + + + L P + FN +S W
Sbjct: 151 LEPIELAEHLTFLEHKSFRRISFTDYQS--YVIHGCLENNPTLERSIALFNGISKWVQLM 208
Query: 162 ILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDK 221
+L+ +P+ RAE++ FI VAKKL +L N ++L AV+ L +SI RL +T + LS +
Sbjct: 209 VLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVT 268
Query: 222 QQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPH------ 275
+ ++++ EL N+ R+ IP LG+ L DL+ + + P +
Sbjct: 269 KNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTEENKVNIV 328
Query: 276 RVTKMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEP 333
++ ++++ L L Q++ + + P + N L + EDD YKLSL LEP
Sbjct: 329 KMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYH----TEDDIYKLSLVLEP 382
>UniRef50_O77086 Cluster: Guanine nucleotide-releasing factor 2; n=7;
melanogaster subgroup|Rep: Guanine nucleotide-releasing
factor 2 - Drosophila melanogaster (Fruit fly)
Length = 1571
Score = 93.9 bits (223), Expect = 1e-17
Identities = 66/241 (27%), Positives = 118/241 (48%), Gaps = 16/241 (6%)
Query: 98 SALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFW 157
S L L ++ Q+TLLD F I+ E+ + + + PN+ FT+ FN++S+W
Sbjct: 1334 SLLDLKSLEIAEQMTLLDAELFTKIEIPEVLLFAKDQCEEKS--PNLNKFTEHFNKMSYW 1391
Query: 158 TVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLS 217
+IL Q K R + + FIK+ K L ++NN +S A++SAL S I RL W
Sbjct: 1392 ARSKILRLQDAKEREKHVNKFIKIMKHLRKMNNYNSYLALLSALDSGPIRRL--EW---Q 1446
Query: 218 KKDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPHRV 277
K ++ L + ++ A R+ L + PCIPY+G+ L DL ++ + + V
Sbjct: 1447 KGITEEVRSFCALIDSSSSFRAYRQALAETNPPCIPYIGLILQDLTFVHVGNQDYLSKGV 1506
Query: 278 TKMNIVLKALERY----QSSEYEIAPLPHVANFLNSVRYIEELQKFV-EDDQYKLSLKLE 332
+ K ++Y ++ P N +R+ + + F+ E++ +++S K++
Sbjct: 1507 INFS---KRWQQYNIIDNMKRFKKCAYPFRRN-ERIIRFFDNFKDFMGEEEMWQISEKIK 1562
Query: 333 P 333
P
Sbjct: 1563 P 1563
>UniRef50_UPI000049A3AF Cluster: Ras guanine nucleotide exchange
factor; n=1; Entamoeba histolytica HM-1:IMSS|Rep: Ras
guanine nucleotide exchange factor - Entamoeba
histolytica HM-1:IMSS
Length = 910
Score = 93.5 bits (222), Expect = 1e-17
Identities = 60/222 (27%), Positives = 104/222 (46%), Gaps = 2/222 (0%)
Query: 106 DVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTV-APNVVAFTKRFNRVSFWTVQEILN 164
++ QLT++D +K I+P EL N+L A NV+ + R N + FW IL+
Sbjct: 671 EIARQLTMVDYNIYKTIQPSELYNSDVFTKNELRYRAENVMRMSDRVNEICFWVASLILS 730
Query: 165 GQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHS-ASIYRLTKTWACLSKKDKQQ 223
RA++M I VA+ L +NN HSL + + + +SI RL KT A L ++
Sbjct: 731 FPDLNNRAKMMTKLINVAEVLFNMNNFHSLAGIYVGIEAYSSISRLKKTRAELPVSAQKT 790
Query: 224 FDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPHRVTKMNIV 283
DKL + G N+ R +L S+ C+P++ + DL +I A + V +
Sbjct: 791 LDKLNKWLGLESNYLLYRNHLSSLKDRCVPFISVIGKDLTFIIEGAKATFDYDVGGVQCK 850
Query: 284 LKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQY 325
L R+Q + ++ + + ++ L +++ + Y
Sbjct: 851 LINFYRHQLANEKVTDYLKFQQYPYTFPVVQPLYQYISNPLY 892
>UniRef50_Q95WR8 Cluster: PXF isoform C; n=4; Caenorhabditis|Rep:
PXF isoform C - Caenorhabditis elegans
Length = 1347
Score = 93.5 bits (222), Expect = 1e-17
Identities = 59/208 (28%), Positives = 104/208 (50%), Gaps = 8/208 (3%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTV 159
L L+ V QLTL D F AI+P E KL+ +P + F + FNR +W
Sbjct: 768 LSLNAQVVAAQLTLQDFSVFSAIEPTEFLD-NLFKLDSKYGSPKLEEFEQLFNREMWWVA 826
Query: 160 QEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKK 219
EI + + RA+++ FIKVA+ +L N +S+FA++S L ++ RL +W +S K
Sbjct: 827 TEICTERHVQKRAKLIKKFIKVARYCRDLRNFNSMFAIMSGLDKPAVRRLHSSWERVSSK 886
Query: 220 DKQQFDKLAELFGETDNWTALREYLKSISL--PCIPYLGIFLTDLVYIDIAHPAGSPHRV 277
+ D++ +L + N + R++L ++ P +P + DL + + S +
Sbjct: 887 YIRMLDEIHQLVDPSRNMSKYRQHLAEVAQEPPVVPIYPVIKKDLTFAHDGNATYSEKLI 946
Query: 278 T--KMNIVLKALE---RYQSSEYEIAPL 300
K+ ++ K++ + S+ YEIA +
Sbjct: 947 NFEKLRLIAKSIRGVMKLSSAPYEIASM 974
>UniRef50_UPI0000499BEE Cluster: Ras guanine nucleotide exchange
factor; n=1; Entamoeba histolytica HM-1:IMSS|Rep: Ras
guanine nucleotide exchange factor - Entamoeba
histolytica HM-1:IMSS
Length = 1214
Score = 91.5 bits (217), Expect = 6e-17
Identities = 65/266 (24%), Positives = 121/266 (45%), Gaps = 19/266 (7%)
Query: 106 DVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNG 165
+ Q+TL+ F IK E WT N ++ K +N ++ + I++
Sbjct: 260 EFARQMTLIIHTAFSKIKLYEFFK--WT--NDKNACKSIQTLVKYYNGFQWYFQKRIVHC 315
Query: 166 QSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFD 225
++ + R I+ I VA LNN SL ++ ++ IYRL T + L + K ++D
Sbjct: 316 KTQEERLIIIKFLIDVANHCKILNNFDSLVCIMQIFLTSPIYRLKNTISKLDNETKSKYD 375
Query: 226 KLAELFGETDNWTALR----EYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPH------ 275
L + NW+ LR + ++S +PC+PY+GI+L+D+ +I + + +
Sbjct: 376 NLLSIVSPEHNWSILRNLINKIIQSSQIPCVPYIGIYLSDMTFISDGNLSRFENGLVNFD 435
Query: 276 RVTKMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEPPS 335
+ KM V++ ++ S Y I+ P + +F+ ++ + E++ Y+ S +EP
Sbjct: 436 KCKKMCSVVRNFDKINSIHYSISHYPILKHFIENIHGENQ-----ENENYEYSKLIEPLD 490
Query: 336 PVGSCAGSKESVKETVLQGNVTTFNI 361
P + E V+ T F I
Sbjct: 491 PFTIKISENGEIIEKVIPSEKTIFEI 516
>UniRef50_P14771 Cluster: Guanine nucleotide exchange factor SDC25;
n=2; Saccharomyces cerevisiae|Rep: Guanine nucleotide
exchange factor SDC25 - Saccharomyces cerevisiae (Baker's
yeast)
Length = 1252
Score = 91.5 bits (217), Expect = 6e-17
Identities = 54/178 (30%), Positives = 91/178 (51%), Gaps = 7/178 (3%)
Query: 98 SALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLT----VAPNVVAFTKRFNR 153
S L + P QLT+L+ + I + W NK T +P + F N+
Sbjct: 947 SILAVDPVLFATQLTILEHEIYCEITIFDCLQKIWK--NKYTKSYGASPGLNEFISFANK 1004
Query: 154 VSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTW 213
++ + ++ RA++++HFI +A+ + NN S+ A+ISAL+S+ IYRL KTW
Sbjct: 1005 LTNFISYSVVKEADKSKRAKLLSHFIFIAEYCRKFNNFSSMTAIISALYSSPIYRLEKTW 1064
Query: 214 ACLSKKDKQQFDKLAELFGETDNWTALREYLKSI-SLPCIPYLGIFLTDLVYIDIAHP 270
+ + + L +L N+ R LKS+ S PC+P+ G++L+DL + D +P
Sbjct: 1065 QAVIPQTRDLLQSLNKLMDPKKNFINYRNELKSLHSAPCVPFFGVYLSDLTFTDSGNP 1122
>UniRef50_Q9NZL6 Cluster: Ral guanine nucleotide dissociation
stimulator-like 1; n=23; Theria|Rep: Ral guanine
nucleotide dissociation stimulator-like 1 - Homo sapiens
(Human)
Length = 768
Score = 91.5 bits (217), Expect = 6e-17
Identities = 53/147 (36%), Positives = 80/147 (54%), Gaps = 5/147 (3%)
Query: 103 SPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLT---VAPNVVAFTKRFNRVSFWTV 159
S D V QLT +D FK + P C W++ +K +AP + A +FN ++ V
Sbjct: 232 SEDLVAEQLTYMDAQLFKKVVPHHCLGCIWSRRDKKENKHLAPTIRATISQFNTLTKCVV 291
Query: 160 QEILNGQSPKA--RAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLS 217
IL G+ K RA+I+ +I +A + L N SL A++SAL S SIYRL KTWA +
Sbjct: 292 STILGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRLKKTWAAVP 351
Query: 218 KKDKQQFDKLAELFGETDNWTALREYL 244
+ F++L+++F + +N RE L
Sbjct: 352 RDRMLMFEELSDIFSDHNNHLTSRELL 378
>UniRef50_UPI000069F86C Cluster: Ral guanine nucleotide dissociation
stimulator (RalGEF) (RalGDS).; n=1; Xenopus
tropicalis|Rep: Ral guanine nucleotide dissociation
stimulator (RalGEF) (RalGDS). - Xenopus tropicalis
Length = 640
Score = 91.1 bits (216), Expect = 7e-17
Identities = 81/274 (29%), Positives = 132/274 (48%), Gaps = 38/274 (13%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWT---KLNKLTVAPNVVAFTKRFNRVSF 156
L D + Q T++D FK + P C W+ K K +AP + A +FN V+
Sbjct: 147 LSFRQDMLAEQFTVMDAELFKKVVPYHCLGCIWSQRDKKGKEHLAPTIRATVSQFNSVTN 206
Query: 157 WTVQEILNGQS--PKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWA 214
+ L +S P+ RA+++ +I+VA++ L N SL A++SAL +I+RL KTW
Sbjct: 207 CVISTCLCDRSLKPQQRAKVIERWIEVARECRILKNFSSLRAILSALQCNAIHRLKKTWD 266
Query: 215 CLSKKDKQQFDKLAELFGETDNWTALREYL-------------KSISL----------PC 251
+S++ + F +L+E+F + +N + RE L S+SL
Sbjct: 267 EVSRESYRIFMELSEIFSDENNHSLSRELLIKVRIKAQACSPYSSVSLLKRLRGGVMQGT 326
Query: 252 IPYLGIFLTDLVYIDIAH----PAG--SPHRVTKMNIVLKALERYQSSEYEIAPLPHVAN 305
IPYLG FLTDLV +D A +G + + K V+ ++ QS+ + LP
Sbjct: 327 IPYLGTFLTDLVMLDTAMKDYLESGLINFEKRRKEFEVIAQIKLLQSACNNYSFLPDE-- 384
Query: 306 FLNSVRYIEELQKFVEDDQYKLSLKLEPPSPVGS 339
+ V + +++ E + Y LS ++EP S S
Sbjct: 385 --SFVEWFHSVERLTEAESYSLSCEIEPLSESAS 416
>UniRef50_A7S390 Cluster: Predicted protein; n=2; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 850
Score = 91.1 bits (216), Expect = 7e-17
Identities = 53/168 (31%), Positives = 82/168 (48%), Gaps = 4/168 (2%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTV 159
L+L +V LTL D F+AI P E W + + PN+ F + NR +FW V
Sbjct: 560 LQLKTQEVARHLTLQDFELFRAIDPREYIYDVWEFGPEFS--PNLAKFEETVNRETFWVV 617
Query: 160 QEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKK 219
EI + R +++ HFIK+AK + N++S FA+IS L ++ RL TW L +
Sbjct: 618 TEICGESNVVKRMKLIKHFIKIAKYCKDCKNINSAFAIISGLGHTAVKRLKNTWEKLPNR 677
Query: 220 DKQQFDKLAELFGETDNWTALREYLKS--ISLPCIPYLGIFLTDLVYI 265
+ ++ L L + + R L S ++ P IP+ + DL I
Sbjct: 678 YYKMYEDLENLMDPSRSMFKYRSLLNSEHVNPPLIPFFPVIKRDLTLI 725
>UniRef50_Q5TND5 Cluster: ENSANGP00000025467; n=1; Anopheles gambiae
str. PEST|Rep: ENSANGP00000025467 - Anopheles gambiae
str. PEST
Length = 1021
Score = 90.6 bits (215), Expect = 1e-16
Identities = 60/209 (28%), Positives = 104/209 (49%), Gaps = 12/209 (5%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTV 159
L+L+ +++ QLTL D F+ I+ E L P +V F + NR FW V
Sbjct: 718 LQLNANELAIQLTLQDFSIFRQIESTEYID-DLFNLKSRYGKPMLVRFAELVNREMFWVV 776
Query: 160 QEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKK 219
E+ + + R +I+ FIK+A+ E N +SLFA++S L A++ RL +TW L K
Sbjct: 777 TEVCSEHNMMRRCKIIKQFIKIARHCKECKNFNSLFAIVSGLGHAAVSRLRQTWEKLPSK 836
Query: 220 DKQQFDKLAELFGETDNWTALREYLK---SISLPCIPYLGIFLTDLVYIDIAHPAGSPHR 276
++ F+ L +L + N + R+ ++ + P IP+ + DL +I + +
Sbjct: 837 YQKLFNDLQDLMDPSRNMSKYRQLIQTELNAQQPVIPFYPVVKKDLTFIHLGND------ 890
Query: 277 VTKMNIVLKALERYQSSEYEIAPLPHVAN 305
TK++ ++ E+ + EI L H+ N
Sbjct: 891 -TKIDSLIN-FEKLRMISKEIRTLLHMCN 917
>UniRef50_Q179F5 Cluster: Guanine nucleotide exchange factor; n=2;
Aedes aegypti|Rep: Guanine nucleotide exchange factor -
Aedes aegypti (Yellowfever mosquito)
Length = 1450
Score = 90.6 bits (215), Expect = 1e-16
Identities = 54/173 (31%), Positives = 91/173 (52%), Gaps = 4/173 (2%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTV 159
L+L+ +++ QLTL D F+ I+ E ++ L P +V F + NR FW V
Sbjct: 766 LQLNANELAIQLTLQDFSIFRQIESTEYIDDLFS-LKSRYGKPMLVKFAELVNREMFWVV 824
Query: 160 QEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKK 219
E+ + + R +I+ FIK+A+ E N +SLFA+IS L A++ RL +TW L K
Sbjct: 825 TEVCSEHNMMRRCKIIKQFIKIARHCKECKNFNSLFAIISGLGHAAVSRLRQTWEKLPSK 884
Query: 220 DKQQFDKLAELFGETDNWTALREYLK---SISLPCIPYLGIFLTDLVYIDIAH 269
++ F+ L EL + N + R+ ++ + P IP+ + DL +I + +
Sbjct: 885 YQKLFNDLQELMDPSRNMSKYRQLIQTELNAQHPVIPFYPVVKKDLTFIHLGN 937
>UniRef50_O95398 Cluster: Rap guanine nucleotide exchange factor 3;
n=33; Euteleostomi|Rep: Rap guanine nucleotide exchange
factor 3 - Homo sapiens (Human)
Length = 881
Score = 90.6 bits (215), Expect = 1e-16
Identities = 56/166 (33%), Positives = 84/166 (50%), Gaps = 3/166 (1%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELT--TCGWTKLNKLTVAPNVVAFTKRFNRVSFWTV 159
+S D+ QLT D F +I EL G L +T A N+ F +RFN + +W
Sbjct: 619 VSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTA-NLERFMRRFNELQYWVA 677
Query: 160 QEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKK 219
E+ P RA+++ FIK+A L E NL+S FAV+ L +++I RL TW L K
Sbjct: 678 TELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHK 737
Query: 220 DKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYI 265
++ + L L + N R L +S P IP++ + L D+ +I
Sbjct: 738 VRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFI 783
>UniRef50_Q1DXK6 Cluster: Putative uncharacterized protein; n=1;
Coccidioides immitis|Rep: Putative uncharacterized
protein - Coccidioides immitis
Length = 848
Score = 89.4 bits (212), Expect = 2e-16
Identities = 67/245 (27%), Positives = 116/245 (47%), Gaps = 7/245 (2%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEEL----TTCGWTKLNKLTVAPNVVAFTKRFNRVS 155
+ + +D +LT +D + A +P EL +T K + NV K+FN ++
Sbjct: 591 MEIPDEDFARELTRIDWVMYSAFRPRELIRHVSTSSENKEKPSSHLENVNRMIKQFNHLA 650
Query: 156 FWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWAC 215
++ +L K RA+ + F+ ++ KL +L N +SL A+I+ L+ IYRL +T A
Sbjct: 651 YFAASMVLLRDKAKHRAQALEKFMNISLKLRQLYNYNSLGAIIAGLNGTPIYRLAQTQAL 710
Query: 216 LSKKDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPH 275
+S K+QF L L G + A R ++ IP+L + L DLV + +
Sbjct: 711 VSHSVKKQFMSLVILMGTQKSHFAYRLAWENSFGERIPFLPLHLRDLVSAEEGNRTFIGD 770
Query: 276 RVT--KMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEP 333
R+ K I+ + Q S+ P H+ + + +E + E++ Y SL++EP
Sbjct: 771 RINWRKFEIMGDVILGVQQSQKTPFPTFHINEIVRRL-VLEAKFESDEEELYTRSLQVEP 829
Query: 334 PSPVG 338
+ VG
Sbjct: 830 SAVVG 834
>UniRef50_Q4SCF7 Cluster: Chromosome 1 SCAF14655, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 1 SCAF14655, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 207
Score = 89.0 bits (211), Expect = 3e-16
Identities = 49/98 (50%), Positives = 63/98 (64%), Gaps = 6/98 (6%)
Query: 256 GIFLTDLVYIDIAHPA-GS----PHRVTKMNIVLKALERYQSS-EYEIAPLPHVANFLNS 309
G++L+DL YID A+P+ GS R MN +L+ + Q S Y++ LPHV +LNS
Sbjct: 5 GMYLSDLTYIDSAYPSTGSILENEQRSNLMNNILRIISDLQRSCTYDVPVLPHVQKYLNS 64
Query: 310 VRYIEELQKFVEDDQYKLSLKLEPPSPVGSCAGSKESV 347
VRYIEELQKFVEDD YKLS K+EP + SKE +
Sbjct: 65 VRYIEELQKFVEDDNYKLSQKIEPGTSTPRANASKEDL 102
>UniRef50_Q8WZA2 Cluster: Rap guanine nucleotide exchange factor 4;
n=53; Coelomata|Rep: Rap guanine nucleotide exchange
factor 4 - Homo sapiens (Human)
Length = 1011
Score = 89.0 bits (211), Expect = 3e-16
Identities = 63/243 (25%), Positives = 108/243 (44%), Gaps = 10/243 (4%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQE 161
+S D+ Q+T+ D F + EL + + N N+ F +RFN + FW V E
Sbjct: 771 MSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTE 830
Query: 162 ILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDK 221
I R +++ FIK+A E NL+S FA++ L + ++ RL TW L K K
Sbjct: 831 ICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFK 890
Query: 222 QQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPHRVT--K 279
+ + + L + N A R + + P IP++ + + D+ + + + V K
Sbjct: 891 KFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEK 950
Query: 280 MNIV---LKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSL---KLEP 333
M ++ + + Y+S + N + Y+ +L V D+Q LS +LEP
Sbjct: 951 MRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLN--VIDNQRTLSQMSHRLEP 1008
Query: 334 PSP 336
P
Sbjct: 1009 RRP 1011
>UniRef50_Q2H8X6 Cluster: Putative uncharacterized protein; n=1;
Chaetomium globosum|Rep: Putative uncharacterized protein
- Chaetomium globosum (Soil fungus)
Length = 1160
Score = 88.2 bits (209), Expect = 5e-16
Identities = 67/245 (27%), Positives = 116/245 (47%), Gaps = 30/245 (12%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKL---NKLTVAPNVVAFTKRFNRVSF 156
L + + QLT+++ + IK E W K + APNV A N+++
Sbjct: 882 LDIDVTEFARQLTIIESRLYSKIKSTECLNKTWQKKVGEGEPEPAPNVKALILHSNQMTN 941
Query: 157 WTVQEILNGQSPKARAEIMAHFIKVA---------------------KKLHELNNLHSLF 195
W + IL+ + R ++ HF+ VA +K LNN +L
Sbjct: 942 WVAEMILSQTDVRKRVVVIKHFVAVADVTPPSSFVSDFVCQQWLTVGQKCRVLNNFSTLT 1001
Query: 196 AVISALHSASIYRLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYL 255
++ISAL +A I RL +TW + ++ + + + +L T N+ RE L + PCIP+
Sbjct: 1002 SIISALGTAPIARLKRTWDQVPQRVQATLEVMRKLMASTKNFGEYREALHGGNPPCIPFF 1061
Query: 256 GIFLTDLVYIDIAHPAGSPHRVTKMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEE 315
G++LTDL +I+ G P + K N++ A +R +++E I + N S++ + E
Sbjct: 1062 GVYLTDLTFIE----DGIPSIIKKTNLINFA-KRAKTAEV-IRDIQQFQNVAYSLQPVSE 1115
Query: 316 LQKFV 320
LQ ++
Sbjct: 1116 LQDYI 1120
>UniRef50_UPI00015B5B51 Cluster: PREDICTED: similar to
ENSANGP00000025467; n=1; Nasonia vitripennis|Rep:
PREDICTED: similar to ENSANGP00000025467 - Nasonia
vitripennis
Length = 1384
Score = 87.8 bits (208), Expect = 7e-16
Identities = 57/203 (28%), Positives = 100/203 (49%), Gaps = 7/203 (3%)
Query: 73 SIFHYKTNSLPAACSINQSWDDIVCSA----LRLSPDDVGNQLTLLDLPCFKAIKPEELT 128
S ++ KTN + ++ D+V + L+L+ +V QLT D F+ I+ E
Sbjct: 679 SRYYLKTNGISETLVADEQAPDLVRESQVHFLQLNAIEVAAQLTFQDFNIFRQIESTEYV 738
Query: 129 TCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHEL 188
+ +K V P + F + NR FW V E+ + + R++I+ FIK+A++ E
Sbjct: 739 DDLFELKSKYGV-PMLSQFAELVNREMFWVVTEVCSEHNIVRRSKIIKQFIKIARQCKEC 797
Query: 189 NNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKS-- 246
N +S+FA++S L ++ RL +W L K ++ F L EL + N + R+ + S
Sbjct: 798 KNFNSMFAIVSGLGHGAVSRLRASWEKLPSKYQRLFSDLQELMDPSRNMSKYRQLVASEQ 857
Query: 247 ISLPCIPYLGIFLTDLVYIDIAH 269
P IP+ + DL +I + +
Sbjct: 858 TQPPIIPFYPVVKKDLTFIHLGN 880
>UniRef50_UPI00006A087A Cluster: Ral guanine nucleotide dissociation
stimulator-like 2 (RalGDS-like factor) (RAS-associated
protein RAB2L).; n=2; Xenopus tropicalis|Rep: Ral
guanine nucleotide dissociation stimulator-like 2
(RalGDS-like factor) (RAS-associated protein RAB2L). -
Xenopus tropicalis
Length = 471
Score = 87.8 bits (208), Expect = 7e-16
Identities = 58/185 (31%), Positives = 95/185 (51%), Gaps = 23/185 (12%)
Query: 107 VGNQLTLLDLPCFKAIKPEELTTCGWTKLNKL----TVAPNVVAFTKRFNRVSFWTVQEI 162
V QLT ++ F + P E W++ +K+ +V + FNR+S
Sbjct: 198 VAEQLTSMEASLFLRVVPYECLGSVWSRRDKVGSHWNRCQSVRETVQHFNRLSGAVTSSC 257
Query: 163 LNGQS--PKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKD 220
+ P+ RA I+ +++VA++ L N S++A+I+AL S +++RL K WA S++
Sbjct: 258 VRDPQLKPQQRARIIEKWVRVAEECRSLRNFSSVYAIITALQSTAVHRLKKVWAETSREI 317
Query: 221 KQQFDKLAELFGETDNWTALREYLKSISLP-C----------------IPYLGIFLTDLV 263
+ + ++ E+F E DN+ +RE L ISL C +PYLG+FLTDLV
Sbjct: 318 LRSYQEMREVFCEKDNYARMRELLFQISLSYCPASVQLQTFPFLQQGVVPYLGVFLTDLV 377
Query: 264 YIDIA 268
+D A
Sbjct: 378 MLDSA 382
>UniRef50_Q9N468 Cluster: Putative uncharacterized protein; n=3;
Caenorhabditis|Rep: Putative uncharacterized protein -
Caenorhabditis elegans
Length = 877
Score = 87.8 bits (208), Expect = 7e-16
Identities = 51/169 (30%), Positives = 83/169 (49%), Gaps = 7/169 (4%)
Query: 106 DVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNG 165
++ QLT +D + I+ EL W + + N+V FT++FN +SFW I+
Sbjct: 640 EIACQLTFIDSQLYHRIESAELLW--WAQEQNEKKSKNLVNFTEQFNNLSFWVRTLIITQ 697
Query: 166 QSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFD 225
+ K R M F+K+ K L E+ N +S A++SA+ S + RL W SK K
Sbjct: 698 GTQKERERHMMKFVKIMKHLREMCNFNSYLAILSAIMSTPLARL--EW---SKNIKDALK 752
Query: 226 KLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSP 274
+ + ++ R L++ PC+PY+GI L DL ++ +P P
Sbjct: 753 EHTAVMDTAQSYKNYRALLQTAKPPCVPYIGIILQDLTFVHAGNPDTIP 801
>UniRef50_Q8IZJ4 Cluster: Ral-GDS-related protein; n=32;
Catarrhini|Rep: Ral-GDS-related protein - Homo sapiens
(Human)
Length = 473
Score = 87.8 bits (208), Expect = 7e-16
Identities = 75/280 (26%), Positives = 125/280 (44%), Gaps = 25/280 (8%)
Query: 80 NSLPAACSINQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTK---LN 136
+S P S+ + + P + QLTL+D FK + E C W +
Sbjct: 196 SSCPCRGSVKNQPSEELPDMTTFPPRLLAEQLTLMDAELFKKVVLHECLGCIWGQGHLKG 255
Query: 137 KLTVAPNVVAFTKRFNRVSFWTVQEILNGQSPKAR--AEIMAHFIKVAKKLHELNNLHSL 194
+AP V A FNR++ L S +AR A ++ H+IKVA++ LNN S+
Sbjct: 256 NEHMAPTVRATIAHFNRLTNCITTSCLGDHSMRARDRARVVEHWIKVARECLSLNNFSSV 315
Query: 195 FAVISALHSASIYRLTKTWACLSKKDKQQFDKLA-----------------ELFGETDNW 237
++SAL S I +L KTWA +S K ++ +L ++ + N
Sbjct: 316 HVIVSALCSNPIGQLHKTWAGVSSKSMKELKELCKKDTAVKRDLLIKAGSFKVATQERNP 375
Query: 238 TALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPHRVTKMNIVLKALERYQSSEYEI 297
++ L+ +P+LG FLT+L +D A P K + ++ L+ Q ++
Sbjct: 376 QRVQMRLRRQKKGVVPFLGDFLTELQRLDSAIPDDLDGNTNKRSKEVRVLQEMQL--LQV 433
Query: 298 APLPHVANFLNS-VRYIEELQKFVEDDQYKLSLKLEPPSP 336
A + + L V Y +++ + + YKLS +LEP +P
Sbjct: 434 AAMNYRLRPLEKFVTYFTRMEQLSDKESYKLSCQLEPENP 473
>UniRef50_A7RH05 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella vectensis
Length = 2289
Score = 87.0 bits (206), Expect = 1e-15
Identities = 73/265 (27%), Positives = 126/265 (47%), Gaps = 36/265 (13%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELT---TCGWTKLNKLTVAPNVVA--FTKRFNRV 154
L P ++ Q+TLLD F A+ +++ G + L P ++ RFN++
Sbjct: 1982 LLFHPKELARQITLLDHEFFCAVTSDDIQKKIAMGTGRRKNLDSQPRLLCERVADRFNQL 2041
Query: 155 SFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFA-VISALHSASIYRLTKTW 213
S W V IL +S + RA++ +FI+ AK+ +L N +++ A V++AL S+SI RL +T
Sbjct: 2042 STWVVASILTEESVEKRAQMFINFIETAKQCLKLRNFNAVMAIVVAALGSSSIRRLARTK 2101
Query: 214 ACLSKKDKQQF--------DKLAELFG----------ETDNWTALREYLKSISLPCIPYL 255
+ K+ +Q K+ LFG +N+ R L++ P +PY
Sbjct: 2102 QLVPKEFLEQCAKIEMLMDTKVPALFGLVVGEYLVDVYANNYKKYRTTLRASPTPAVPYF 2161
Query: 256 GIFLTDLVYIDIAHP---AGSPHRVTK---MNIVLKALERYQSSEYEIAPLPHVANFLNS 309
GI++ DL +I +P G ++K + IV+ + ++Q Y + V +L S
Sbjct: 2162 GIYMKDLTFIAEGNPDFLKGGLVNISKRRQVYIVINEIRQFQKKSYHFQEVAEVREYLLS 2221
Query: 310 VRYIEELQKFVEDDQYKLSLKLEPP 334
+ E D + +S +LEPP
Sbjct: 2222 QELVS------EGDLHLVSCQLEPP 2240
>UniRef50_Q7K3Z6 Cluster: GH01501p; n=4; Diptera|Rep: GH01501p -
Drosophila melanogaster (Fruit fly)
Length = 861
Score = 86.6 bits (205), Expect = 2e-15
Identities = 49/165 (29%), Positives = 84/165 (50%), Gaps = 4/165 (2%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELT--TCGWTKLNKLTVAPNVVAFTKRFNRVSFWTV 159
LS ++ +TL + F A+ EL T G K+T N+ F +RFN V +W V
Sbjct: 621 LSTKELAYHITLFEWDLFWAVHEYELLYHTFGRHHFGKITA--NLDVFLRRFNEVQYWIV 678
Query: 160 QEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKK 219
E+++ S R ++ FIK+A E NL++ FAV+ L + ++ RL +TW + K
Sbjct: 679 TELVSTPSLSKRVGLVRKFIKLAAYCKEYQNLNAFFAVVMGLSNMAVSRLQQTWEKIPSK 738
Query: 220 DKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVY 264
++ F + L + N A R ++ + P IP++ + L D+ +
Sbjct: 739 FRKIFQEFEALIDPSRNHRAYRVFVGKLQPPLIPFMPLLLKDMTF 783
>UniRef50_Q17MY4 Cluster: Ral guanine nucleotide exchange factor,
putative; n=2; Endopterygota|Rep: Ral guanine nucleotide
exchange factor, putative - Aedes aegypti (Yellowfever
mosquito)
Length = 717
Score = 86.6 bits (205), Expect = 2e-15
Identities = 50/137 (36%), Positives = 79/137 (57%), Gaps = 3/137 (2%)
Query: 110 QLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNGQ--S 167
QLT +D+ FK + P + W+ +K +V+A +FN VSF + IL
Sbjct: 235 QLTRMDMELFKRLIPHQCLGAIWSNRDKHECG-SVLATVTQFNAVSFRVISSILIEPRLK 293
Query: 168 PKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFDKL 227
P+ RA +++ +I +A++L L N SL A+IS L S ++YRL+KTWA L ++ + + +L
Sbjct: 294 PQERALLISTWIDIAQELRLLKNFSSLKAIISGLQSNAVYRLSKTWAALPREKLELYTEL 353
Query: 228 AELFGETDNWTALREYL 244
A +F E +N A RE L
Sbjct: 354 ARIFSEDNNAWAQREVL 370
>UniRef50_Q16I23 Cluster: Guanine-nucleotide exchange factor c3g; n=1;
Aedes aegypti|Rep: Guanine-nucleotide exchange factor c3g
- Aedes aegypti (Yellowfever mosquito)
Length = 1131
Score = 85.8 bits (203), Expect = 3e-15
Identities = 50/156 (32%), Positives = 81/156 (51%), Gaps = 7/156 (4%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTV 159
L L ++ Q+TLLD F I+ E+ W + +PN+ FT+ FN++S+W
Sbjct: 983 LDLKSAEIAEQMTLLDAELFHKIEIPEVLI--WAQEQNEERSPNLTTFTEHFNKMSYWAR 1040
Query: 160 QEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKK 219
+IL + K R + + FIK+ K L ++NN +S A++SAL SA I RL W +
Sbjct: 1041 SQILRQEDAKDREKHVIKFIKIMKHLRKINNYNSYLALLSALDSAPIRRL--EW---HRT 1095
Query: 220 DKQQFDKLAELFGETDNWTALREYLKSISLPCIPYL 255
+ + L + ++ A R+ L + PCIPY+
Sbjct: 1096 ITEGLKEYCALIDSSSSFRAYRQALAETNPPCIPYM 1131
>UniRef50_UPI0000DB6F3E Cluster: PREDICTED: similar to Gef26
CG9491-PA; n=1; Apis mellifera|Rep: PREDICTED: similar
to Gef26 CG9491-PA - Apis mellifera
Length = 1348
Score = 85.4 bits (202), Expect = 4e-15
Identities = 55/203 (27%), Positives = 101/203 (49%), Gaps = 7/203 (3%)
Query: 73 SIFHYKTNSLPAACSINQSWDDIVCSA----LRLSPDDVGNQLTLLDLPCFKAIKPEELT 128
S ++ KTN + ++ +++ + L+L+ +V QLTL D F+ I+ E
Sbjct: 680 SRYYLKTNGISETFVADEQAPELIRESQVHFLQLNAVEVAIQLTLQDFSIFRQIESTEYV 739
Query: 129 TCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHEL 188
+ ++ V P + F + NR FW V E+ + + R++I+ FIK+A++ E
Sbjct: 740 DDLFELKSRYGV-PMLRQFAELVNREMFWVVTEVCSEHNLVRRSKIIKQFIKIARQCKEC 798
Query: 189 NNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKS-- 246
N +S+FA++S L ++ RL +W L K ++ F L EL + N + R+ + S
Sbjct: 799 KNFNSMFAIVSGLGHGAVSRLRASWEKLPSKYQRLFSDLQELMDPSRNMSKYRQLVASEQ 858
Query: 247 ISLPCIPYLGIFLTDLVYIDIAH 269
P IP+ + DL +I + +
Sbjct: 859 TQPPIIPFYPVVKKDLTFIHLGN 881
>UniRef50_Q4REE9 Cluster: Chromosome 10 SCAF15123, whole genome
shotgun sequence; n=2; Tetraodontidae|Rep: Chromosome 10
SCAF15123, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 1448
Score = 85.4 bits (202), Expect = 4e-15
Identities = 62/268 (23%), Positives = 127/268 (47%), Gaps = 36/268 (13%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTV 159
+ L P ++ QLTLL+ ++A++P EL WTK +K +PN++ + ++ W
Sbjct: 872 MTLHPIEIARQLTLLESELYRAVRPSELVGSVWTKEDKEKNSPNLLRMIRHTTNLTLWFE 931
Query: 160 QEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTW------ 213
+ I+ + + R ++ I++ + ELNN + + V+SA++S IYRL T+
Sbjct: 932 KCIVETMNLEERVAVLLRVIEILQVFQELNNFNGVLEVVSAINSVPIYRLDHTFEVRTAR 991
Query: 214 ------------------ACLSKKDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYL 255
+ ++ ++ ++ EL D++ LKSI+ PC+P+
Sbjct: 992 THTHTHTRQIGFNCFFLLQAIPERKRRVLEEAVEL--SQDHFKKYLAKLKSINPPCVPFF 1049
Query: 256 GIFLTDLVYIDIAHPAG-SPHRVTKMNI--------VLKALERYQSSEYEIAPLPHVANF 306
GI+LT+++ + +P + H +N + +++YQ+ Y + + F
Sbjct: 1050 GIYLTNILKTEEGNPDFLTRHGKELINFSKRRKVAEITGEIQQYQNQPYCLKVEHEIRRF 1109
Query: 307 LNSVRYIEEL-QKFVEDDQYKLSLKLEP 333
++ + + +K D +K+SL +EP
Sbjct: 1110 FENLNPMGNMGEKEFADYLFKMSLDIEP 1137
>UniRef50_Q9UHV5 Cluster: Rap guanine nucleotide exchange
factor-like protein 1; n=15; Euteleostomi|Rep: Rap
guanine nucleotide exchange factor-like protein 1 - Homo
sapiens (Human)
Length = 456
Score = 85.4 bits (202), Expect = 4e-15
Identities = 64/243 (26%), Positives = 110/243 (45%), Gaps = 11/243 (4%)
Query: 101 RLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQ 160
R+ P+DV N LT F+ + E + N+ +R + V+ W
Sbjct: 216 RVEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHWVAT 275
Query: 161 EILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKD 220
E+L ++P RA+++ FIK+A + +L S +AV+ L +A++ RL TW L K
Sbjct: 276 EVLLCEAPGKRAQLLKKFIKIAALCKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKF 335
Query: 221 KQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHP--AGSPHRVT 278
K F K L N + RE + + P IP++ + L DL ++ +
Sbjct: 336 KNLFRKFENLTDPCRNHKSYREVISKMKPPVIPFVPLILKDLTFLHEGSKTLVDGLVNIE 395
Query: 279 KMNIV---LKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQ---YKLSLKLE 332
K++ V ++ + +Y+S + N L + Y+ + Q V D+Q ++LS KLE
Sbjct: 396 KLHSVAEKVRTIRKYRSRPL-CLDMEASPNHLQTKAYVRQFQ--VIDNQNLLFELSYKLE 452
Query: 333 PPS 335
S
Sbjct: 453 ANS 455
>UniRef50_Q8TDF6 Cluster: RAS guanyl-releasing protein 4; n=32;
Theria|Rep: RAS guanyl-releasing protein 4 - Homo
sapiens (Human)
Length = 673
Score = 85.4 bits (202), Expect = 4e-15
Identities = 65/238 (27%), Positives = 110/238 (46%), Gaps = 6/238 (2%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQE 161
L ++ LT L+ F+AI P++L + + + P + N VS W
Sbjct: 200 LETGELAQHLTYLEFRSFQAITPQDLRS--YVLQGSVRGCPALEGSVGLSNSVSRWVQVM 257
Query: 162 ILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDK 221
+L+ P RA+++ FI VA++LH+L N ++L AV L ++I RL + A LS
Sbjct: 258 VLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDST 317
Query: 222 QQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPH---RVT 278
+ +L EL +N+ R + +P LG+ L DLV + A P P +
Sbjct: 318 KALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLP 377
Query: 279 KMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEPPSP 336
K+N + L+ + + + P + L+ + +L + ED+ Y+LS EP P
Sbjct: 378 KLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDL-FYTEDEIYELSYAREPRCP 434
>UniRef50_Q6BNH1 Cluster: Debaryomyces hansenii chromosome E of strain
CBS767 of Debaryomyces hansenii; n=3;
Saccharomycetaceae|Rep: Debaryomyces hansenii chromosome
E of strain CBS767 of Debaryomyces hansenii -
Debaryomyces hansenii (Yeast) (Torulaspora hansenii)
Length = 1550
Score = 85.4 bits (202), Expect = 4e-15
Identities = 57/173 (32%), Positives = 94/173 (54%), Gaps = 8/173 (4%)
Query: 106 DVGNQLTLLDLPCFKAIKPEELTTCGWT-KLNKLTVAPNVVAFTKRFNRVSFWTVQEILN 164
++ QLTL++ F +IKP+EL +T K L +APN+ N +S + ++ IL
Sbjct: 1268 ELAKQLTLIESHIFCSIKPDELLNQNFTAKRAHLKLAPNIRQSLLFTNCLSGYVLESILQ 1327
Query: 165 GQ-SPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQ 223
+ + K R I+ ++KVA L N +SL ++I++L S I RL K W LS K K+
Sbjct: 1328 PKINQKMRVNIIKTWLKVAISCLYLRNFNSLASIITSLQSHLITRLAKIWVDLSDKYKEL 1387
Query: 224 FDKLAELFGETDNW----TALREYLKS--ISLPCIPYLGIFLTDLVYIDIAHP 270
++ L+ + N+ T LR +L S ++P +PY +FL DL ++ +P
Sbjct: 1388 YEYLSGIIHPQKNFNVYRTKLRNFLVSNEYNIPIVPYFSLFLQDLTFVTDGNP 1440
>UniRef50_A2DHX3 Cluster: RasGEF domain containing protein; n=1;
Trichomonas vaginalis G3|Rep: RasGEF domain containing
protein - Trichomonas vaginalis G3
Length = 914
Score = 85.0 bits (201), Expect = 5e-15
Identities = 59/194 (30%), Positives = 98/194 (50%), Gaps = 16/194 (8%)
Query: 107 VGNQLTLLDLPCFKAIKPEELTTCGWT-KLNKLTVAPNVVAFTKRFNRVSFWTVQEILN- 164
+ N + +L F I +E CGW K N +APN+V KRFN++S + +++
Sbjct: 663 IANHIMYHELAIFNNINYKEFVACGWANKTNPEAIAPNLVTIAKRFNKLSQYIQYSLVHY 722
Query: 165 -GQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSK---KD 220
+ PKA A IMA +I V +K E+ N H LF + SAL + + RL W L KD
Sbjct: 723 TKRDPKATAIIMAQWILVMQKCSEIRNFHGLFVIDSALSAPPVTRLHGCWDALKDVQVKD 782
Query: 221 -----KQQFDKLAEL---FGETDNWTA-LREYLKSISLPCIPYLGIFLTDLVYIDIAHP- 270
K+ +D L+ + + N+ A + K+ +P++G +LTD+ +I +P
Sbjct: 783 SNQSMKELYDSLSSICSPLRKFKNYKAEINNENKTKPEMALPFMGPWLTDMAFIKDGNPK 842
Query: 271 AGSPHRVTKMNIVL 284
+ + + K+NI +
Sbjct: 843 SKNDNGFEKLNITM 856
>UniRef50_A2Q880 Cluster: Contig An01c0100, complete genome; n=10;
Trichocomaceae|Rep: Contig An01c0100, complete genome -
Aspergillus niger
Length = 1116
Score = 85.0 bits (201), Expect = 5e-15
Identities = 65/255 (25%), Positives = 123/255 (48%), Gaps = 13/255 (5%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELT---TCGWTKLNKLTVAPNVVAFTKRFNRVSF 156
+ + +D +LT +D F + +P +L + + +K+ +V K+FN V+F
Sbjct: 657 MEIPDEDFARELTRIDWIMFNSFRPRDLVRHVSISGVEKDKILSLKHVNRMIKQFNHVAF 716
Query: 157 WTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACL 216
+ IL PK RA+ + F+ +A KL LNN +SL AVI+ ++ ++RL++T +
Sbjct: 717 FVASVILLRDKPKHRAKALEKFMNIALKLRRLNNYNSLGAVIAGINGTPVHRLSQTRELV 776
Query: 217 SKKDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHP---AGS 273
+ ++ F +L L G + A R + IP+L + DLV + + +
Sbjct: 777 PVQTQKDFMRLVILMGTQKSHFAYRLAWDNSFAERIPFLPLHRRDLVSAEEGNKTFVGDN 836
Query: 274 PHRVT--KMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVED-DQYKLSLK 330
+R+ K ++ + + Q S+ P PH+ + R + E++ +D D Y S++
Sbjct: 837 KNRINWRKFEVMGEVVLGIQRSQK--TPYPHMPKYEEVERLVLEIKLSGDDEDLYSRSMQ 894
Query: 331 LEPPSPVGSCAGSKE 345
+EP + G G K+
Sbjct: 895 VEPSA--GGDTGRKK 907
>UniRef50_Q92565 Cluster: Rap guanine nucleotide exchange factor 5;
n=35; Euteleostomi|Rep: Rap guanine nucleotide exchange
factor 5 - Homo sapiens (Human)
Length = 580
Score = 85.0 bits (201), Expect = 5e-15
Identities = 59/236 (25%), Positives = 117/236 (49%), Gaps = 13/236 (5%)
Query: 106 DVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNG 165
D+ +L D F +I +EL +++ N+ +R N V W EIL
Sbjct: 348 DLALELMNFDWSLFNSIHEQELIYFTFSRQGSGEHTANLSLLLQRCNEVQLWVATEILLC 407
Query: 166 QSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFD 225
R +++ FIK+A NL+S FA++ L++AS+ RL++TW + K K+ F
Sbjct: 408 SQLGKRVQLVKKFIKIAAHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFS 467
Query: 226 KLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPHRVT--KMNIV 283
+L L + N A R+ K + P IP++ + L D+ +I + + V K++++
Sbjct: 468 ELESLTDPSLNHKAYRDAFKKMKPPKIPFMPLLLKDVTFIHEGNKTFLDNLVNFEKLHMI 527
Query: 284 ---LKALERYQSSEY-EIAPLPH--VANFLNSVRYIEELQKFVEDDQYKLSLKLEP 333
++ L +++++ +++P H + +++N + I+ Q ++LS ++EP
Sbjct: 528 ADTVRTLRHCRTNQFGDLSPKEHQELKSYVNHLYVIDSQQAL-----FELSHRIEP 578
>UniRef50_Q4SD50 Cluster: Chromosome 1 SCAF14643, whole genome
shotgun sequence; n=6; Euteleostomi|Rep: Chromosome 1
SCAF14643, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 742
Score = 84.2 bits (199), Expect = 8e-15
Identities = 48/150 (32%), Positives = 77/150 (51%), Gaps = 5/150 (3%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTV---APNVVAFTKRFNRVSF 156
L D V QLT +D FK + P W++ +K AP + A +FN V+
Sbjct: 205 LSFEADLVAEQLTYMDALLFKRVIPHHCLGSIWSQRDKKDSKHSAPTIRATIAQFNAVTA 264
Query: 157 WTVQEILNGQS--PKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWA 214
V +L + P RA ++ +I +A++ N SL A++SAL S +YRL + WA
Sbjct: 265 CVVSTVLKHRPLRPHVRARVIQRWIDIAQECRIRKNFSSLRAIVSALQSNPLYRLKRVWA 324
Query: 215 CLSKKDKQQFDKLAELFGETDNWTALREYL 244
C+ K Q F++L+++F + +N+ RE L
Sbjct: 325 CVHKDSMQTFEELSDIFSDHNNYLTSRELL 354
>UniRef50_Q9U4U5 Cluster: Ral guanine nucleotide exchange factor 2;
n=5; Diptera|Rep: Ral guanine nucleotide exchange factor
2 - Drosophila melanogaster (Fruit fly)
Length = 954
Score = 84.2 bits (199), Expect = 8e-15
Identities = 53/137 (38%), Positives = 76/137 (55%), Gaps = 2/137 (1%)
Query: 110 QLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNGQ-SP 168
QLT +D FK + P + W + + + VVA +FN V F V IL + P
Sbjct: 463 QLTRMDTELFKRLIPHQCLGHTWARRDS-GGSETVVATINQFNAVLFRVVSSILIDRLKP 521
Query: 169 KARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFDKLA 228
+ RA ++ +I +A++L L N SL A+ISAL+S SIYRL+K W L K+ + F +LA
Sbjct: 522 QERALNISRWIDIAQELRMLKNFSSLKAIISALNSNSIYRLSKIWEVLPKERMEVFTELA 581
Query: 229 ELFGETDNWTALREYLK 245
+ E +N LRE LK
Sbjct: 582 NICSEDNNAWTLREVLK 598
Score = 35.1 bits (77), Expect = 5.1
Identities = 38/135 (28%), Positives = 59/135 (43%), Gaps = 19/135 (14%)
Query: 252 IPYLGIFLTDLVYIDIAHPAGSPHRVTKMNIVLKALERYQSSEY-EIAPLPHVANFLNSV 310
IPYLG FLTDL I A+P +T+ ++ +R + +I L AN N
Sbjct: 633 IPYLGTFLTDLTMIHTANP----DYLTENKLINFDKKRKEFEVLAQIKLLQGAANTYNLQ 688
Query: 311 ------RYIEELQKFVEDDQYKLSLKLEPPSPV--GSCAGSKESVKETV------LQGNV 356
+ + F E + ++LS +LEPP P S + S+ T + G+
Sbjct: 689 ADALFDHWFNSMPVFDEREAFELSCRLEPPPPAPRKSVVSTNTSLTNTTASSTASIMGHR 748
Query: 357 TTFNISPSHKLGSGS 371
T +I + G+GS
Sbjct: 749 KTDSIHSNSSSGAGS 763
>UniRef50_Q553C1 Cluster: Ras guanine nucleotide exchange factor; n=3;
Dictyostelium discoideum|Rep: Ras guanine nucleotide
exchange factor - Dictyostelium discoideum AX4
Length = 1138
Score = 83.8 bits (198), Expect = 1e-14
Identities = 58/227 (25%), Positives = 105/227 (46%), Gaps = 12/227 (5%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQE 161
L P ++ QLT+LD I +++ + N +P++V T RFN + W E
Sbjct: 890 LRPHEIARQLTILDHELLTQITKQQMLDYAVHQTN----SPSIVKVTDRFNYLVLWVSTE 945
Query: 162 ILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACL-SKKD 220
I+ + + R E + F+ +A L N +S A+I+A+ SI +L +TW + + K
Sbjct: 946 IVLSLTIEKRIETIFKFVNIALNCWYLKNFNSAIAIIAAMSKPSIEKLKQTWGFIRNTKA 1005
Query: 221 KQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPA------GSP 274
+L EL T N LR+ + S+ P IPYLG + + + I + + +
Sbjct: 1006 NAPIQELKELILPT-NVARLRKIMDSVEAPFIPYLGAYFSHSIAIHAGNKSIVNEQYINM 1064
Query: 275 HRVTKMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVE 321
+ M +++++ Q +Y + P+ + FL + E Q + E
Sbjct: 1065 QKYDMMGKIIRSITVAQEKKYNLTPVGVLQKFLTDSFVLTEKQLYSE 1111
>UniRef50_A7SFW1 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 968
Score = 83.4 bits (197), Expect = 1e-14
Identities = 56/203 (27%), Positives = 98/203 (48%), Gaps = 8/203 (3%)
Query: 140 VAPNVVAFTKRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVIS 199
++ N+ RFN V +W + EI R ++ FIK+A + NL+S FA+I
Sbjct: 765 ISANLDICLSRFNEVHYWVITEICLATQLSKRVFLLKKFIKIASYCKDYKNLNSAFAIIM 824
Query: 200 ALHSASIYRLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFL 259
AL+ A+I RLT+TW + K K+ + +L + + N R + + P IP++ + +
Sbjct: 825 ALNCAAISRLTQTWEKIPNKYKKLYRELDAILDPSGNHRVYRLVVAKMKPPVIPFMVLIM 884
Query: 260 TDLVYIDIAHPAGSPHRVT--KMNIV---LKALERYQSSEYEIAPLPHVANFLNSV-RYI 313
D+ I+ + V KM ++ L+ +E +S+ ++ P P + V Y+
Sbjct: 885 KDITIINYGNKTFVNELVNFEKMRMITISLRLVEYCRSAPFD-TPAPSSLKIPSEVPSYV 943
Query: 314 EELQKFVEDDQY-KLSLKLEPPS 335
LQ +LS +LEPP+
Sbjct: 944 RNLQVIDNGKTLTQLSYRLEPPT 966
>UniRef50_A2G2Z9 Cluster: RasGEF domain containing protein; n=1;
Trichomonas vaginalis G3|Rep: RasGEF domain containing
protein - Trichomonas vaginalis G3
Length = 595
Score = 83.4 bits (197), Expect = 1e-14
Identities = 63/241 (26%), Positives = 115/241 (47%), Gaps = 13/241 (5%)
Query: 106 DVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNG 165
+V Q+T+ + A++ EL W +PN+V+ N +S W I+
Sbjct: 360 EVSMQITVWTSSRYYAVERSELLNGSWQNPRLKHRSPNIVSIIDHMNLISKWVSTLIIMS 419
Query: 166 QSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFD 225
+ R ++M +FI V + L +L N +A++ S ++RL ++ L KK++ F+
Sbjct: 420 PKSEERVKLMTYFIDVMQCLFDLQNYCDTYAILGGFESPEVFRLHNHFSQLPKKERDFFN 479
Query: 226 KLAELFGE-TDNWTALREYLKS---ISLPCIPYLGIFLTDLV-YIDIAHPAGSPHRVTKM 280
K+ ++F E N +RE +S P IPYLGI L+D+ Y D+ + + M
Sbjct: 480 KVHKIFMEGGSNMKLIRELHESSQKTEKPIIPYLGILLSDIFKYCDV-----EKNTIDGM 534
Query: 281 NIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQ--KFVEDDQ-YKLSLKLEPPSPV 337
+ K+L+ + E ++ H FL ++ ++L F++ Y+LSL +E +
Sbjct: 535 LNISKSLKTFSYIEAFLSFKKHKYYFLPIIQVQDKLDVLPFLDSTYLYELSLDIENDASS 594
Query: 338 G 338
G
Sbjct: 595 G 595
>UniRef50_UPI0000EC9E1A Cluster: Rap guanine nucleotide exchange
factor 3 (cAMP-regulated guanine nucleotide exchange
factor I) (cAMP-GEFI) (Exchange factor directly
activated by cAMP 1) (Epac 1) (Rap1
guanine-nucleotide-exchange factor directly activated by
cAMP).; n=1; Gallus gallus|Rep: Rap guanine nucleotide
exchange factor 3 (cAMP-regulated guanine nucleotide
exchange factor I) (cAMP-GEFI) (Exchange factor directly
activated by cAMP 1) (Epac 1) (Rap1
guanine-nucleotide-exchange factor directly activated by
cAMP). - Gallus gallus
Length = 766
Score = 82.6 bits (195), Expect = 3e-14
Identities = 58/209 (27%), Positives = 102/209 (48%), Gaps = 6/209 (2%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELTT--CGWTKLNKLTVAPNVVAFTKRFNRVSFWTV 159
+S D+ + LT D FK+I E+ G K +++T A N+ +RFN + +W
Sbjct: 542 ISSKDLASHLTDHDWNLFKSIHQVEMIQYIMGPQKFHEVTTA-NLERMMRRFNELQYWVA 600
Query: 160 QEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKK 219
E+ RA+++ FIK+A L E NL+S FAV+ + + ++ RL KTW L K
Sbjct: 601 TELCLCPELGRRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGVSNTAVSRLAKTWERLPHK 660
Query: 220 DKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPHRVT- 278
++ L + + N R + +S P IP++ + L D+ +I + + + +
Sbjct: 661 IRKLHAALERMLDPSWNHRVYRLAVAKLSPPIIPFVPLLLKDMTFIHEGNRTLAENLINF 720
Query: 279 -KMNIVLKALERYQSSEYEI-APLPHVAN 305
KM+++ K + Q + APL + N
Sbjct: 721 EKMHMMAKTVRILQRCRGQAHAPLSPLRN 749
>UniRef50_UPI00015616C2 Cluster: PREDICTED: similar to ral guanine
nucleotide dissociation stimulator; n=3; Equus
caballus|Rep: PREDICTED: similar to ral guanine
nucleotide dissociation stimulator - Equus caballus
Length = 809
Score = 82.2 bits (194), Expect = 3e-14
Identities = 77/252 (30%), Positives = 111/252 (44%), Gaps = 18/252 (7%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKL---NKLTVAPNVVAFTKRFNRVSF 156
L P V QLT +D FK ++P W + +K +AP V A +F VS
Sbjct: 483 LDFPPKLVAEQLTRMDAELFKKVEPRHCLGFVWCQRPNGSKEYLAPTVRATINQFLHVSG 542
Query: 157 WTVQEILNGQSPKA--RAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWA 214
+ L S A RA ++ +I+VAK+ L N SL A++SAL S SI RL KTW
Sbjct: 543 CVITTCLGDLSMTAQDRARVVELWIQVAKECRVLGNYASLRAIVSALQSPSISRLQKTWG 602
Query: 215 CLSKKD--------KQQFDKLAELFGE-TDNWTALREYLKSISLPCIPYLGIFLTDLVYI 265
+++K K Q+ +L E T T+L IP+LG FL L+ +
Sbjct: 603 RVARKSSRKLKRFIKDQWVSRRQLVKEATSMLTSLETGPTGAQKGLIPFLGTFLNYLLLL 662
Query: 266 DIA---HPAGSPHRVTKMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVED 322
D + G+ K + K E+ + E L H+ + E ++ ED
Sbjct: 663 DTNMEDYLEGNEINFEKRSEEFKVTEQIFLLQ-EAVHLYHIEAEERFGAWFEAMEPLSED 721
Query: 323 DQYKLSLKLEPP 334
+ Y LS LEPP
Sbjct: 722 ESYSLSCHLEPP 733
>UniRef50_UPI0000499502 Cluster: Ras guanine nucleotide exchange
factor; n=1; Entamoeba histolytica HM-1:IMSS|Rep: Ras
guanine nucleotide exchange factor - Entamoeba
histolytica HM-1:IMSS
Length = 850
Score = 82.2 bits (194), Expect = 3e-14
Identities = 64/238 (26%), Positives = 103/238 (43%), Gaps = 15/238 (6%)
Query: 106 DVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNG 165
++ QLT++D +K ++P EL C + K+ APNV R + +S W IL
Sbjct: 615 EIAKQLTMVDFGIYKNVRPTELFDCSFDKMKYR--APNVCKMLARVDEISHWIGTMILMF 672
Query: 166 QSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSAS-IYRLTKTWACLSKKDKQQF 224
+ RA++M FI +A KL L N +L L + S I RL T L+++ +
Sbjct: 673 PDVEMRAKLMNKFISIADKLLTLQNYQALAGFYVGLEAYSPIARLQNTRNLLTQQSVKTM 732
Query: 225 DKLAELFG--ETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPHRVTKMNI 282
L FG N+ R +K + C+P++ + DL +I P + I
Sbjct: 733 KILESYFGLVNNSNYKNYRSLIKDVKGACVPFIAVVTKDLTFIT---EGNEPKVKNEDGI 789
Query: 283 VLKALERYQSSEYEIAPLPHVANFLNSV-------RYIEELQKFVEDDQYKLSLKLEP 333
L ER + +I F + Y+++L ED Y++S+ LEP
Sbjct: 790 SLINFERQEMCLTQIDDFLRFQQFTFNFPIVQPLNGYLQQLTSLPEDLLYRISIILEP 847
>UniRef50_Q95V18 Cluster: Guanine nucleotide exchange factor; n=3;
Sophophora|Rep: Guanine nucleotide exchange factor -
Drosophila melanogaster (Fruit fly)
Length = 1573
Score = 81.8 bits (193), Expect = 5e-14
Identities = 52/173 (30%), Positives = 87/173 (50%), Gaps = 4/173 (2%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTV 159
L L+ ++ QLTL D F+ I+ E + ++ V P + F + NR FW V
Sbjct: 865 LHLNAYELAIQLTLQDFGTFRQIESTEYVDELFELRSRYGV-PMLSKFAELVNREMFWVV 923
Query: 160 QEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKK 219
EI + R +I+ FIK+A+ E N +S+FA++S L ++ RL +TW L K
Sbjct: 924 SEICAEHNIVRRMKIVKQFIKIARHCKECRNFNSMFAIVSGLGHGAVSRLRQTWEKLPSK 983
Query: 220 DKQQFDKLAELFGETDNWTALREYLKSISL---PCIPYLGIFLTDLVYIDIAH 269
++ F+ L +L + N + R+ + + L P IP+ I DL +I + +
Sbjct: 984 YQRLFNDLQDLMDPSRNMSKYRQLVSAELLAQHPIIPFYPIVKKDLTFIHLGN 1036
>UniRef50_Q9UL65 Cluster: RAS guanyl-releasing protein 2; n=35;
Euteleostomi|Rep: RAS guanyl-releasing protein 2 - Homo
sapiens (Human)
Length = 671
Score = 81.8 bits (193), Expect = 5e-14
Identities = 76/241 (31%), Positives = 114/241 (47%), Gaps = 12/241 (4%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEE---LTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWT 158
L P ++ LT L+ F I ++ T G T N P + F FN VS W
Sbjct: 215 LEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCTVDN-----PVLERFISLFNSVSQWV 269
Query: 159 VQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSK 218
IL+ + RA ++ HF+ VA+KL +L N ++L AV+ L +SI RL +T + +S
Sbjct: 270 QLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSP 329
Query: 219 KDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPHRVT 278
+ + ++ L EL T N+ R L + P LG+ L DLV + +A P T
Sbjct: 330 ETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPILGVHLKDLVALQLALPDWLDPART 389
Query: 279 KMN-IVLKALERYQSSEYEIAPL--PHVAN-FLNSVRYIEELQKFVEDDQYKLSLKLEPP 334
++N +K L + L P AN L S+ + Q ED+ Y+LSL+ EP
Sbjct: 390 RLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQREPR 449
Query: 335 S 335
S
Sbjct: 450 S 450
>UniRef50_Q2GVZ4 Cluster: Putative uncharacterized protein; n=3;
Sordariomycetes|Rep: Putative uncharacterized protein -
Chaetomium globosum (Soil fungus)
Length = 959
Score = 81.4 bits (192), Expect = 6e-14
Identities = 65/259 (25%), Positives = 123/259 (47%), Gaps = 16/259 (6%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELT---TCGWTKLNKLTVAPNVVAFTKRFNRVSF 156
+ L +D+ ++LT +D F +I+ + + + K NV FN V+
Sbjct: 701 MELDAEDIADELTRIDWVMFSSIRIRDKVRHVSLSHDQKEKCRNLKNVNRMVSHFNHVAH 760
Query: 157 WTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACL 216
W IL K RA + FI VA++L ++NN + L AV++ ++ ++I+RL +T A +
Sbjct: 761 WVSNMILIRDKAKHRAPCLEKFIVVAQRLRQMNNYNGLAAVLAGINGSAIHRLAQTRAAI 820
Query: 217 SKKDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYID-----IAHPA 271
S + +++ LA L G + A R ++ SLP IP++ + DLV + P
Sbjct: 821 SAEAQKRHAGLALLMGTQKSHFAYRLAWENSSLPRIPFMPLHRRDLVSAEEGSKTFVGPN 880
Query: 272 GSPHRVTKMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQ-YKLSLK 330
G K ++ + L S+ + P P++ + + + +D++ Y+ S++
Sbjct: 881 GDRINWKKFEVLGEVLLPIMKSQGQ--PYPNLQRHDACKELVLDCRVTTDDEELYQRSVQ 938
Query: 331 LEPPSPVGSCAGSKESVKE 349
+EP S G+ ES ++
Sbjct: 939 VEP-----STGGAGESTRK 952
>UniRef50_UPI00015616DC Cluster: PREDICTED: hypothetical protein,
partial; n=1; Equus caballus|Rep: PREDICTED:
hypothetical protein, partial - Equus caballus
Length = 420
Score = 81.0 bits (191), Expect = 8e-14
Identities = 49/125 (39%), Positives = 68/125 (54%), Gaps = 5/125 (4%)
Query: 98 SALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKL---TVAPNVVAFTKRFNRV 154
S + SP DV QLT +D FK ++P E W K N+ VAP V A +FNRV
Sbjct: 296 SLMAFSPRDVAEQLTAIDAEVFKNVEPSECLGSTWGKRNRPGHENVAPTVWATVVQFNRV 355
Query: 155 SFWTVQEILNGQSPKAR--AEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKT 212
+ L + AR A+++ +I+VA++ L N+ SL AV+SAL S I+RL KT
Sbjct: 356 VKCVMTSCLGDPNVTARGRAKVLERWIEVARECRALRNISSLHAVLSALQSVPIHRLKKT 415
Query: 213 WACLS 217
W +S
Sbjct: 416 WGKVS 420
>UniRef50_UPI00015A741B Cluster: Hypothetical protein; n=3; Danio
rerio|Rep: Hypothetical protein - Danio rerio
Length = 723
Score = 81.0 bits (191), Expect = 8e-14
Identities = 96/380 (25%), Positives = 157/380 (41%), Gaps = 58/380 (15%)
Query: 106 DVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKL---TVAPNVVAFTKRFNRVSFWTVQEI 162
D+ QLT+LD F + P C W++ +K + V A +FN V+ + +
Sbjct: 228 DIAEQLTILDAELFSKVVPFHCLGCIWSQRDKKENQNLVSTVRATIAQFNVVTNCVITSL 287
Query: 163 L-------------NGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRL 209
L + SP RA+I+ +I VA++ H+L N SL A++SAL S ++YRL
Sbjct: 288 LCPPATSPPGSPSCHRSSPTYRAKIIEKWISVAQECHQLRNFSSLRAILSALQSNAVYRL 347
Query: 210 TKTWACLSKKDKQQFDKLAELFGETDNWTALREYL-----------------------KS 246
KTWA +S++ F+ L + F + + RE L +S
Sbjct: 348 KKTWAVISRESMAVFEHLCDTFPDENCVLINREILVESETQEGNQAADVETHSAPKSPRS 407
Query: 247 ISLPCIPYLGIFLTDLVYIDIA---HPAGSPHRVTKMN---IVLKALERYQSS--EYEIA 298
S +PYLG +LT L +D A + G K +L + + Q+S Y +
Sbjct: 408 SSSGEVPYLGTYLTVLTMLDTALTDNVEGGLINFEKRRKEFEILSLIRQLQASCAHYTLQ 467
Query: 299 PLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEPPSPVGSCAGSKESVKETVLQGNVTT 358
P + +++NS + + QK Y+LS +LEP PV C S S ++ +
Sbjct: 468 SHPRIISWINSSMSLSD-QK-----SYELSRELEP--PVDPCPSSPNSWSHRLIAKKLNL 519
Query: 359 FNISPSHKLGSGSLRLQGTSHQGKFIPTHRKCRSLGSNIFGKSHTEDKMDEKTPAGSVNL 418
++ + S G+ + + + +I + T P
Sbjct: 520 KTLADQISVSSSGSSGSDMEDLGRDLSSPNTSPLVYKDISVDTPTS---SPTPPPSCQRS 576
Query: 419 LDDTLLESPSSVACAKMSQS 438
L L ESPSS + + S S
Sbjct: 577 LQADLPESPSSTSSSSSSSS 596
>UniRef50_Q6P112 Cluster: Ral guanine nucleotide dissociation
stimulator-like 1; n=3; Clupeocephala|Rep: Ral guanine
nucleotide dissociation stimulator-like 1 - Danio rerio
(Zebrafish) (Brachydanio rerio)
Length = 804
Score = 81.0 bits (191), Expect = 8e-14
Identities = 48/145 (33%), Positives = 76/145 (52%), Gaps = 5/145 (3%)
Query: 105 DDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLT---VAPNVVAFTKRFNRVSFWTVQE 161
D V QLT +D FK + P W++ +K AP + A +FN V+ V
Sbjct: 272 DLVAEQLTYMDALLFKKVVPHHCLGSIWSQRDKKDGKQSAPTIRATITQFNAVTACVVST 331
Query: 162 ILNGQS--PKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKK 219
IL + P A I+ +I +A++ N SL A++SAL S +YRL +TWA ++K
Sbjct: 332 ILRQRQIRPHLCARIIQRWIDIAQECRIRKNFSSLRAIVSALQSNPLYRLKRTWASVAKD 391
Query: 220 DKQQFDKLAELFGETDNWTALREYL 244
Q F++L+++F + +N+ RE L
Sbjct: 392 SMQMFEELSDIFSDQNNYLTSRELL 416
>UniRef50_A4QNU6 Cluster: Zgc:162151 protein; n=6; Euteleostomi|Rep:
Zgc:162151 protein - Danio rerio (Zebrafish)
(Brachydanio rerio)
Length = 708
Score = 80.6 bits (190), Expect = 1e-13
Identities = 63/239 (26%), Positives = 112/239 (46%), Gaps = 8/239 (3%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVA-PNVVAFTKRFNRVSFWTVQ 160
L P ++ LT L+ +K+I+ T ++ V P + FN +S W
Sbjct: 151 LEPIELAEHLTFLE---YKSIRRISFTDYQSYVIHGCLVDNPTLERSIALFNGISQWVQL 207
Query: 161 EILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKD 220
+L+ +P+ RAE++ +I VA+KL L N ++L AV+ L +SI RL +T + LS +
Sbjct: 208 MVLSKLTPQHRAEVITKYIHVAQKLLHLQNFNTLMAVVGGLSHSSISRLKETHSHLSPEV 267
Query: 221 KQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHP---AGSPHRV 277
+ ++++ EL N+ A R+ IP LG+ L DL+ + + +
Sbjct: 268 TKIWNEMTELVSSNGNYCAYRKAFGESKGFKIPILGVHLKDLIAVHVVFADWVEDGKVNI 327
Query: 278 TKMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEPPSP 336
KM + S + +A + + + + +L + ED+ Y+LSL EP +P
Sbjct: 328 AKMQQLFLTFNELVSLQSAVAQVEPNMDLIYLLNLSLDLY-YTEDEIYELSLLREPRNP 385
>UniRef50_UPI0000499955 Cluster: Ras guanine nucleotide exchange
factor; n=1; Entamoeba histolytica HM-1:IMSS|Rep: Ras
guanine nucleotide exchange factor - Entamoeba
histolytica HM-1:IMSS
Length = 1166
Score = 80.2 bits (189), Expect = 1e-13
Identities = 72/273 (26%), Positives = 129/273 (47%), Gaps = 13/273 (4%)
Query: 67 SNRQHDSI-FHYKTNSLPAACSINQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPE 125
+N+Q++ I N + Q +I + L + Q+TL++ F I
Sbjct: 239 NNKQNEDINIQQIQNKVTTTEEEQQVLKEIEFNFLNIPAIVFAKQVTLIEYDLFMKIHIS 298
Query: 126 ELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKL 185
EL + W N+ A N++ F + N++ W VQ IL P R I+ I+V ++
Sbjct: 299 ELYS--WNNSNRENTASNIIKFLQHRNKMEHWYVQLILLAP-PNQRLGILKRIIEVGIRM 355
Query: 186 HELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLK 245
++LNN + L V +AL S IYRL + L++ DK+ F ++ + +G D + L
Sbjct: 356 NDLNNWNGLVEVATALDSFPIYRLEHLFLQLNENDKENFRQI-KSYGSID--SLLMNDSN 412
Query: 246 SISLPCIPYLGIFLTDLVYID-IAHPAGSPHRVTKMNI-VLKALERYQSSEYEIAPLPHV 303
I CIPY+ +L +V I+ A P+ +N+ + L Y + P++
Sbjct: 413 MIPGACIPYVNTYLRKIVEINKNAQPSIQSGGFVLINVEKCRQLAHYIVDWVQCQKYPYL 472
Query: 304 ANFLNSVR-YIE-ELQKF--VEDDQYKLSLKLE 332
+++ +IE L K E+++Y+LS+++E
Sbjct: 473 FGHNQAMQEWIESHLVKINCNEENEYQLSIQIE 505
>UniRef50_A7EYT6 Cluster: Putative uncharacterized protein; n=1;
Sclerotinia sclerotiorum 1980|Rep: Putative
uncharacterized protein - Sclerotinia sclerotiorum 1980
Length = 1095
Score = 80.2 bits (189), Expect = 1e-13
Identities = 49/167 (29%), Positives = 84/167 (50%), Gaps = 3/167 (1%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLN---KLTVAPNVVAFTKRFNRVSF 156
+ + DD+ +++T +D F +I+ +L LN K NV FN ++
Sbjct: 723 MEIPDDDLADEMTRIDWVMFSSIRLRDLVRHVSLSLNQKEKCKSLANVNRMINHFNHIAK 782
Query: 157 WTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACL 216
W IL K RA I+ F+ +A KL +LNN + L AV++ ++ +I+RLT+T +
Sbjct: 783 WVANMILMRDKAKHRAHILEKFMNIALKLRQLNNYNGLAAVLAGINGTAIHRLTQTRNLV 842
Query: 217 SKKDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLV 263
+++F +L L G + A R ++ LP IP++ + DLV
Sbjct: 843 PPDVQKRFARLVLLMGTQKSHFAYRLAWENSPLPRIPFIPLTRRDLV 889
>UniRef50_UPI00015A6BDA Cluster: UPI00015A6BDA related cluster; n=1;
Danio rerio|Rep: UPI00015A6BDA UniRef100 entry - Danio
rerio
Length = 725
Score = 79.0 bits (186), Expect = 3e-13
Identities = 50/172 (29%), Positives = 81/172 (47%), Gaps = 3/172 (1%)
Query: 96 VCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVS 155
V L LS ++ NQL+ + F I+P + KL+ N+ F N+ +
Sbjct: 85 VVPLLSLSSMEIANQLSARNYLLFSCIEPTDYIN-DLFKLHPQEPPTNLRNFEGLVNQET 143
Query: 156 FWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWAC 215
FW EI+ + R +I+ HFIK+A + N +S+FA+IS + A + RL TW
Sbjct: 144 FWVATEIVQETNLAKRVKIIKHFIKIALHCRDCKNFNSMFAIISGFNLAPVSRLRSTWER 203
Query: 216 LSKKDKQQFDKLAELFGETDNWTALREYLKSISL--PCIPYLGIFLTDLVYI 265
L K ++ +L ++F + N R L +L P IP + DL ++
Sbjct: 204 LPGKYEKLLAELQDVFDPSRNMAKYRNLLNKHNLQPPVIPLFPVIKKDLTFL 255
>UniRef50_UPI00004D6636 Cluster: ral guanine nucleotide dissociation
stimulator-like 3; n=3; Xenopus tropicalis|Rep: ral
guanine nucleotide dissociation stimulator-like 3 -
Xenopus tropicalis
Length = 794
Score = 79.0 bits (186), Expect = 3e-13
Identities = 51/158 (32%), Positives = 82/158 (51%), Gaps = 21/158 (13%)
Query: 134 KLNKLTVAPNVVAFTKRFNRVSFWTVQEILNGQS--PKARAEIMAHFIKVAKKLHELNNL 191
K VAP+V A +FN V+ + +L+ P+ RA+++ +I +A+ L N
Sbjct: 337 KKENRNVAPSVRATVAQFNAVTACVIASVLSDVQLKPQQRAKVLEKWICIAQHCRFLRNF 396
Query: 192 HSLFAVISALHSASIYRLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYL------- 244
SL A++SAL S +YRL +TWA +S+ + F KL+++F + +N RE L
Sbjct: 397 SSLRAILSALQSNPLYRLKRTWAAVSRDNLNIFHKLSDIFSDENNHGMSREILTKENNSA 456
Query: 245 ------------KSISLPCIPYLGIFLTDLVYIDIAHP 270
+++ +PYLG FLTDL+ +D A P
Sbjct: 457 TSEYRPVCPPHTQTVLQGTVPYLGTFLTDLIMLDTALP 494
>UniRef50_Q6MBG2 Cluster: Putative uncharacterized protein; n=1;
Candidatus Protochlamydia amoebophila UWE25|Rep:
Putative uncharacterized protein - Protochlamydia
amoebophila (strain UWE25)
Length = 1121
Score = 78.6 bits (185), Expect = 4e-13
Identities = 73/270 (27%), Positives = 122/270 (45%), Gaps = 18/270 (6%)
Query: 119 FKAIKPEELTTCGWTK---LNKLTVAPNVVAFTKRFNRVSFWTVQEILNGQ--SPKARAE 173
FKAI+PEE W K +K APN+ FN+++ + QEIL S K R
Sbjct: 606 FKAIQPEEFHGLKWNKGTAEDKRNNAPNITTNIAFFNQIARFVGQEILMNPTYSSKDRMR 665
Query: 174 IMAHFIKVAKKLH--ELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFDKLAELF 231
+ F+K+A + + N A+I+ L++A ++ T +S + K +KL L
Sbjct: 666 VYGAFVKMADRFANGDPRNYEMTTAIIAGLNAAPVFN-TMQKESISNEIKATLNKLQTLL 724
Query: 232 GETDNWTALREYLKSISLPCIPYL---GIFLTDLVYIDIAHPAGSPHRVTKMNIVLKAL- 287
N ALR+ K + PY+ G++LTD ++D +P ++ LK L
Sbjct: 725 STDFNSKALRDAYKGLQSKATPYMPKTGVYLTDFTFLDEGNPETKSDGISLNLKKLKLLG 784
Query: 288 --ERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEPPSPVGSC--AGS 343
+R +E + PL NF N + I + + ED Y ++ P + GS A
Sbjct: 785 EQQRRIENEAQALPLNQNLNF-NIIGQILQSKLPSEDQLYARKEEIHPRTKAGSISQADK 843
Query: 344 KESVKETVLQGNVTTFNISPSHKLGSGSLR 373
K++ E Q + +F ++ + G+L+
Sbjct: 844 KKTSSEPTSQ-QIASFLVNHQSESTYGALK 872
>UniRef50_A6SRC2 Cluster: Putative uncharacterized protein; n=1;
Botryotinia fuckeliana B05.10|Rep: Putative
uncharacterized protein - Botryotinia fuckeliana B05.10
Length = 978
Score = 78.2 bits (184), Expect = 6e-13
Identities = 48/167 (28%), Positives = 85/167 (50%), Gaps = 3/167 (1%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLN---KLTVAPNVVAFTKRFNRVSF 156
+ +S D+ +++T +D F +I+ +L LN K NV FN ++
Sbjct: 741 MEISNADLADEMTRIDWVMFSSIRLRDLVRHVSLSLNQKEKCKSLANVNRMINHFNHIAK 800
Query: 157 WTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACL 216
W IL K RA+I+ F+ +A +L +LNN + L AV++ ++ +I+RLT+T +
Sbjct: 801 WVANMILMRDKAKHRAQILEKFMNIALRLRQLNNYNGLAAVLAGINGTAIHRLTQTRNLV 860
Query: 217 SKKDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLV 263
+++F +L L G + A R ++ LP IP++ + DLV
Sbjct: 861 PADVQKRFARLVLLMGTQKSHFAYRLAWENSPLPRIPFIPLTRRDLV 907
>UniRef50_A2ETX5 Cluster: RasGEF domain containing protein; n=1;
Trichomonas vaginalis G3|Rep: RasGEF domain containing
protein - Trichomonas vaginalis G3
Length = 701
Score = 77.8 bits (183), Expect = 7e-13
Identities = 49/164 (29%), Positives = 79/164 (48%), Gaps = 4/164 (2%)
Query: 105 DDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILN 164
D++ Q+T+ + AI +EL C W+K APNV A T FN ++ W EIL
Sbjct: 424 DELARQITMYAGKFYYAITEKELLDCAWSKPRIRHRAPNVCAITSHFNCLNQWVQHEILF 483
Query: 165 GQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQF 224
++ + R ++ F ++A+K + + A+ +A + IYRL LS
Sbjct: 484 AETLEKRFKLWELFTRLAQKFWDNQDYFDGMAIATAFQANPIYRLKNHKQLLSPNVMDPI 543
Query: 225 DKLAELFGETDNWTALREY----LKSISLPCIPYLGIFLTDLVY 264
DK+ N+ AL++ LK S IPY+G++LT L +
Sbjct: 544 DKIMNDARSEKNFAALQQLHNDALKKGSGTVIPYVGVYLTQLTF 587
>UniRef50_A2DMC1 Cluster: RasGEF domain containing protein; n=1;
Trichomonas vaginalis G3|Rep: RasGEF domain containing
protein - Trichomonas vaginalis G3
Length = 486
Score = 77.8 bits (183), Expect = 7e-13
Identities = 44/171 (25%), Positives = 85/171 (49%), Gaps = 2/171 (1%)
Query: 101 RLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQ 160
++ P ++ Q+T+ F I P EL W ++ PN++ + F+ +S +
Sbjct: 249 QIEPHELARQITIFHSHIFHNITPLELLAALWGN-SECGGCPNIIRLQEHFDLLSRFISH 307
Query: 161 EILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKK- 219
I+ +PK RA + +V ++ N + LF+VI + S+ R+ +T K
Sbjct: 308 SIIFPATPKERANEFKRWFEVGQQFEAQLNFNGLFSVICGITHRSVVRMEQTMKIAYKSI 367
Query: 220 DKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHP 270
+K++ D L +L ++ R+ L++ + C+P++G F DLVYI ++P
Sbjct: 368 NKKELDALTDLCEIAQDFKNYRQRLQNTTDHCVPFIGCFQKDLVYIQESYP 418
>UniRef50_Q4RS43 Cluster: Chromosome 7 SCAF15001, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 7 SCAF15001, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 1578
Score = 77.0 bits (181), Expect = 1e-12
Identities = 43/134 (32%), Positives = 68/134 (50%), Gaps = 2/134 (1%)
Query: 134 KLNKLTVAPNVVAFTKRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHS 193
KL+ + N+ F + N+ +FW EIL + R + + HFIK+A E N +S
Sbjct: 819 KLDTSIGSRNLKQFEEVINQETFWVASEILKEPNTLKRMKTIKHFIKIALHCRECKNFNS 878
Query: 194 LFAVISALHSASIYRLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISL--PC 251
+FA+IS L+ A + RL +W L K ++ F L ++F + N R L S S+ P
Sbjct: 879 MFAIISGLNLAPVARLRSSWEKLPSKYEKLFGDLQDVFDPSRNMAKYRNVLSSQSMQPPI 938
Query: 252 IPYLGIFLTDLVYI 265
IP + DL ++
Sbjct: 939 IPLFPVVKKDLTFL 952
>UniRef50_A5E0J4 Cluster: Putative uncharacterized protein; n=1;
Lodderomyces elongisporus NRRL YB-4239|Rep: Putative
uncharacterized protein - Lodderomyces elongisporus
(Yeast) (Saccharomyces elongisporus)
Length = 1660
Score = 76.6 bits (180), Expect = 2e-12
Identities = 68/243 (27%), Positives = 119/243 (48%), Gaps = 21/243 (8%)
Query: 39 STIPLNSQQSFTKDDCACYYNYGHGENGSNRQHDSIFHYKT----NSLPAACSI-NQSW- 92
ST+ L+S+Q T ++ Y G + + ++ + HYK N +P I +QSW
Sbjct: 1312 STLLLSSKQLETIENIIMTYRTILGASWCSTKY--LEHYKPLNLQNLMPHFAIICDQSWV 1369
Query: 93 -DDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWT-KLNKLTVAPNVVAFTKR 150
+ + L + ++ QLT+++ F AI+PEEL +T K L ++PNV
Sbjct: 1370 LSNYRPNLLDFNGLEIAKQLTIIESTIFTAIQPEELLNQNFTNKRAHLKLSPNVRLSLLF 1429
Query: 151 FNRVSFWTVQEILNGQ-SPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRL 209
N +S + ++ +L S K R + ++K+A L N +SL A+I+AL S I R+
Sbjct: 1430 TNCLSNYVLESVLQPNLSDKERVNTVKVWLKIAISSLYLRNFNSLAAIIAALQSHLITRV 1489
Query: 210 TKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSI----------SLPCIPYLGIFL 259
WA LS+K LA + N+T R ++++ +P +PY+ +F+
Sbjct: 1490 DFLWANLSQKYIDLHQYLASILSMEKNYTTYRSKIRNLLASSSNKQNAPIPIVPYINLFI 1549
Query: 260 TDL 262
+D+
Sbjct: 1550 SDI 1552
>UniRef50_Q55EC7 Cluster: RasGEF domain-containing protein; n=1;
Dictyostelium discoideum AX4|Rep: RasGEF
domain-containing protein - Dictyostelium discoideum AX4
Length = 960
Score = 76.2 bits (179), Expect = 2e-12
Identities = 55/217 (25%), Positives = 100/217 (46%), Gaps = 12/217 (5%)
Query: 125 EELTTCGWTKLNKLTVAP--NVVAFTKRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVA 182
EE TT + + + V P N+ F ++ N ++ + EIL + R + FI+ A
Sbjct: 746 EESTTTPYVGTSFVEVVPAENIHKFVRKCNNLARFVSTEILKQTKLQKRVATIERFIEAA 805
Query: 183 KKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFDKLAELFGETDNWTALRE 242
+K N+ ++F+++ L SI RL+ TW +S+++ F+ L + + ++ RE
Sbjct: 806 EKCLANNDYAAVFSIVEPLVDQSIERLSDTWRNVSQRNLATFEHLKSIVSKENDHKKYRE 865
Query: 243 YLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPHRVTKM----NIVLKALERYQSSEYEIA 298
L PCIP + + L +L +I+ + P P + + K L+ Q +
Sbjct: 866 LLPDAKPPCIPNIHLLLDELSFIETSSPRLLPGGIVNFFHYRQLSRKILQSQQLQSHCFR 925
Query: 299 PLPHVANFLNSVRYIEELQKFVEDDQYK-LSLKLEPP 334
P+P + L + + +D+ K SLK EPP
Sbjct: 926 PIPSIQKVLT-----KPPSELFDDELIKNNSLKCEPP 957
>UniRef50_A7TGT9 Cluster: Putative uncharacterized protein; n=1;
Vanderwaltozyma polyspora DSM 70294|Rep: Putative
uncharacterized protein - Vanderwaltozyma polyspora DSM
70294
Length = 1421
Score = 76.2 bits (179), Expect = 2e-12
Identities = 49/182 (26%), Positives = 95/182 (52%), Gaps = 16/182 (8%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWT-KLNKLTVAPNVVAFTKRFNRVSFWT 158
+ L+P +V QLTL++ + +I+P EL + K + L VA +V N++S +
Sbjct: 1132 INLNPLEVAKQLTLIESKLYMSIEPFELVNENYLEKKSNLNVAIHVRMIMNFTNQLSHYV 1191
Query: 159 VQEILNGQ-SPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLS 217
++ IL+ + + R + ++K+A + N +S+ ++++ L + +I RLT W L
Sbjct: 1192 MESILSPEINNNDRVNRLRSWLKIALSVLYFRNYNSVASIMTVLQNHAITRLTFLWDLLD 1251
Query: 218 KKDKQQFDKLAELFGETDNWTALREYLKSI--------------SLPCIPYLGIFLTDLV 263
+KD + ++ L+ + +N+ R LK+I +LPC+P+ +FL DL
Sbjct: 1252 EKDTELYEYLSRIVHPNNNFKVYRNKLKNIMNENLPNGLHAAKSALPCVPFFNLFLQDLT 1311
Query: 264 YI 265
+I
Sbjct: 1312 FI 1313
>UniRef50_O15211 Cluster: Ral guanine nucleotide dissociation
stimulator-like 2; n=26; Euteleostomi|Rep: Ral guanine
nucleotide dissociation stimulator-like 2 - Homo sapiens
(Human)
Length = 777
Score = 76.2 bits (179), Expect = 2e-12
Identities = 75/275 (27%), Positives = 121/275 (44%), Gaps = 51/275 (18%)
Query: 105 DDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNK---LTVAPNVVAFTKRFNRVSFWTVQE 161
D + QLTLLD F + P + W ++ + P+V A +FN+V+ V
Sbjct: 245 DHLAEQLTLLDAELFLNLIPSQCLGGLWGHRDRPGHSHLCPSVRATVTQFNKVAGAVVSS 304
Query: 162 ILNGQS--------------PKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIY 207
+L S P RA ++ +I+VA++ L N S++AV+SAL S+ I+
Sbjct: 305 VLGATSTGEGPGEVTIRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPIH 364
Query: 208 RLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYL-KSISLP---------------- 250
RL W ++ + F L ++F E DN++ RE L + + L
Sbjct: 365 RLRAAWGEATRDSLRVFSSLCQIFSEEDNYSQSRELLVQEVKLQSPLEPHSKKAPRSGSR 424
Query: 251 ---CIPYLGIFLTDLVYIDIAHPAGSPH------RVTKMNIVLKALERYQSS--EYEIAP 299
+PYLG FL DLV +D A + + K VL L R Q+ Y + P
Sbjct: 425 GGGVVPYLGTFLKDLVMLDAASKDELENGYINFDKRRKEFAVLSELRRLQNECRGYNLQP 484
Query: 300 LPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEPP 334
+ +L +R + E Q +++S ++EPP
Sbjct: 485 DHDIQRWLQGLRPLTEAQ------SHRVSCEVEPP 513
>UniRef50_A7S271 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 422
Score = 75.8 bits (178), Expect = 3e-12
Identities = 66/237 (27%), Positives = 108/237 (45%), Gaps = 14/237 (5%)
Query: 104 PDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEIL 163
P+++ QLT L+ + I + T +KL + + FN +S W +L
Sbjct: 11 PEEIAEQLTYLEFRMLRRIPFSDWKAYSLT--SKLENTTYLERYVSMFNGLSKWIQAMVL 68
Query: 164 NGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQ 223
N S + RA+ + F KVA+ L EL N + L AV L+++ + RL +T +SK K+
Sbjct: 69 NHTSAEDRAKCIEKFQKVAQSLKELQNFNGLLAVTGGLNNSVLSRLLQTREYVSKDCKEY 128
Query: 224 FDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIA------HPAGSPHR- 276
+ L E +N+ R+ L + IP L I L DL+ A + H+
Sbjct: 129 MNLLTEFLSSENNYATYRKRLSCCAGFYIPILRIQLKDLIATHTALSDTVNDKLINVHKL 188
Query: 277 VTKMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEP 333
VT I+ K++ Q++ + P + N L + + ED+ Y+LSL EP
Sbjct: 189 VTLAGIISKSIV-CQTTPPLVTPNMELLNMLR----VSLQPRLSEDELYELSLAREP 240
>UniRef50_A7RT22 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella vectensis
Length = 1437
Score = 75.4 bits (177), Expect = 4e-12
Identities = 46/168 (27%), Positives = 84/168 (50%), Gaps = 3/168 (1%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQE 161
++P +LT++D +AI+ +E+ W +++ +P+V A + +NR+S V
Sbjct: 1149 VNPSAFAEELTMIDSEMLRAIEFDEIKNGAWREIDVEQRSPHVHAMIEFYNRLSAICVAN 1208
Query: 162 ILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDK 221
IL+ +S K RA+I+ IK+A+K + NN +S A++ + + RL TW + ++ K
Sbjct: 1209 ILSKESAKDRAKIITKIIKIAEKCAQFNNFNSCKALLISFRFHVVSRLCDTWKQVPRRAK 1268
Query: 222 QQFDKLAELFGETDNWTALREY---LKSISLPCIPYLGIFLTDLVYID 266
L + D LR + K + I +LG L + YI+
Sbjct: 1269 STMGHLLAMTSSRDQKAILRRHQKVCKKQGVNSIQFLGDVLHQVHYIE 1316
>UniRef50_Q6CUP1 Cluster: Similar to ca|CA0382|IPF16030 Candida
albicans; n=1; Kluyveromyces lactis|Rep: Similar to
ca|CA0382|IPF16030 Candida albicans - Kluyveromyces
lactis (Yeast) (Candida sphaerica)
Length = 1360
Score = 75.4 bits (177), Expect = 4e-12
Identities = 50/186 (26%), Positives = 94/186 (50%), Gaps = 17/186 (9%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLN-KLTVAPNVVAFTKRFNRVSFWTVQ 160
L+P +V Q++L++ F I P EL C ++ N L+ +PNV + N +S + ++
Sbjct: 1071 LNPLEVSKQISLIESTIFLKITPPELLKCKYSSKNPDLSKSPNVNSIITLTNLLSNYVLE 1130
Query: 161 EILNGQSP-KARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKK 219
IL P K RA + ++++A N ++L ++++ L S I RL+ W LS +
Sbjct: 1131 SILMPGIPLKKRALRIKSWLRIALSSLYFRNFNALASIMTTLQSYVISRLSMLWGMLSNE 1190
Query: 220 DKQQFDKLAELFGETDNWTALREYLKSI---------------SLPCIPYLGIFLTDLVY 264
D + F+ L+++ +N+ R+ ++ + LP +P+ +FL DL +
Sbjct: 1191 DVELFEYLSKIIHPNNNYKVYRKKIEKLVTESSSSSGLLSSKSVLPVVPFFNLFLQDLTF 1250
Query: 265 IDIAHP 270
ID +P
Sbjct: 1251 IDEGNP 1256
>UniRef50_UPI0000498500 Cluster: Ras guanine nucleotide exchange
factor; n=1; Entamoeba histolytica HM-1:IMSS|Rep: Ras
guanine nucleotide exchange factor - Entamoeba
histolytica HM-1:IMSS
Length = 1208
Score = 74.9 bits (176), Expect = 5e-12
Identities = 57/238 (23%), Positives = 107/238 (44%), Gaps = 9/238 (3%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQE 161
+ P + Q+TL+ F+ I+ E+ W+ K + N+V FN + +
Sbjct: 255 IHPIEYARQITLIVSDMFRRIRLYEMLM--WSNGEKES-CQNIVYAQTFFNGLQNHFTRM 311
Query: 162 ILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDK 221
ILN RA I+ ++VA E +N +L ++ +++SI+RL +++ +S + K
Sbjct: 312 ILNETETTQRAAIIERLVRVADYCFEYHNFDTLLCILLLFNTSSIHRLKRSFDSISGESK 371
Query: 222 QQFDKLAELFGETDNWTALREYLKS-ISLPCIPYLGIFLTDLVYIDIAHPAGSPHRVT-- 278
+ +KL + NW LRE + + P +PY+G+ L+DL + + + V
Sbjct: 372 KILNKLIPIACPDKNWNVLREESRQLVGKPTVPYIGLILSDLTFTNFGNKTKENEMVNFG 431
Query: 279 KMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFV---EDDQYKLSLKLEP 333
K + LE+ + + N I + + V + + + LSLK+EP
Sbjct: 432 KCRQIAHILEQVMFMHQQTYAQLIIKNIEIQAAIISDSRYEVTMSDKEAFDLSLKIEP 489
>UniRef50_A7S619 Cluster: Predicted protein; n=2; Eumetazoa|Rep:
Predicted protein - Nematostella vectensis
Length = 417
Score = 74.9 bits (176), Expect = 5e-12
Identities = 49/179 (27%), Positives = 89/179 (49%), Gaps = 18/179 (10%)
Query: 103 SPDDVGNQLTLLDLPCFKAIKPEELTTCGWTK--------LNKLTVAPNVVAFTKRFNRV 154
SP + QL+L++L I PEE + L+ + ++ A+ + FNR+
Sbjct: 161 SPTIMAQQLSLIELERLANIGPEEFVQTFIPRDEADFKSTLSYIKRTSSLEAYVEWFNRL 220
Query: 155 SFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWA 214
+ EI G + K RA+++ +FI+VA ++ N +S A+I+ ++ + + RL KTW
Sbjct: 221 GYLVATEICLGHNKKVRAKVIDYFIEVATDCYDRGNFNSAMAIIAGINMSPVARLKKTW- 279
Query: 215 CLSKKDKQQFDKLAELFGETDNWTALREYLKSISLP-------CIPYLGIFLTDLVYID 266
SK ++FD+L N+ A R K+ L IP+ G+F+ D+ +++
Sbjct: 280 --SKVKNRKFDRLEREMNPASNFAAYRASFKAAHLRKSDKNEYVIPFFGLFIKDVYFLN 336
>UniRef50_Q0ULM6 Cluster: Putative uncharacterized protein; n=1;
Phaeosphaeria nodorum|Rep: Putative uncharacterized
protein - Phaeosphaeria nodorum (Septoria nodorum)
Length = 1032
Score = 74.5 bits (175), Expect = 7e-12
Identities = 49/164 (29%), Positives = 81/164 (49%), Gaps = 3/164 (1%)
Query: 103 SPDDVGNQLTLLDLPCFKAIKPEELT---TCGWTKLNKLTVAPNVVAFTKRFNRVSFWTV 159
S + + +LT +D F +++P +L + + + NV T+ FN V +
Sbjct: 665 SDEAIAKELTRIDWIMFSSVRPRDLVRHVSLNAEERKRCRNLENVTRMTEHFNHVFYLVQ 724
Query: 160 QEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKK 219
IL PK RA ++ ++K+A++L +LNN +SL A+IS + SA ++RL T + +
Sbjct: 725 NYILLRDKPKHRALMLEKWMKIARQLRKLNNYNSLTAIISGIKSAPVHRLLATRDLVPQA 784
Query: 220 DKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLV 263
F KL L G + A R + S IPY+ + DLV
Sbjct: 785 TTHDFLKLDILMGSQKSHFAYRLAWDNSSGERIPYIPLHRRDLV 828
>UniRef50_Q8IS17 Cluster: Nucleotide exchange factor RasGEF F; n=2;
Dictyostelium discoideum|Rep: Nucleotide exchange factor
RasGEF F - Dictyostelium discoideum (Slime mold)
Length = 1127
Score = 74.1 bits (174), Expect = 9e-12
Identities = 64/256 (25%), Positives = 118/256 (46%), Gaps = 19/256 (7%)
Query: 106 DVGNQLTLLDLPCFKAIKPEE--LTTCGWTKLN-KLTVAPNVVAFTKRFNRVSFWTVQEI 162
++ Q+TL++ F AI P E + G+ + + +PN++ F R VS W V +
Sbjct: 838 EIARQMTLVESKLFGAIPPPEFMVRVIGYGEFQYNMATSPNLMTFVNRATDVSRWIVHTV 897
Query: 163 LN-GQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDK 221
LN + K + +++ FIK + L +LNN +L +V+ L + + + + +
Sbjct: 898 LNESRDKKNKMKMLDKFIKTTECLRQLNNFQTLHSVLQGLQHPLLLSRPDLF---TPRHR 954
Query: 222 QQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPHRVT--- 278
+ LF + DN+ RE L C+P++ I D I+ P+ + +
Sbjct: 955 EIIADHEMLFSKIDNYKLYREALARSQPACVPWIDIIREDFAQIERDQPSNMNNLINFTK 1014
Query: 279 KMNI--VLKALERYQSSEYEIAPLPHVANFLNSV-RYIE-ELQKFVEDDQYKLSLKLE-- 332
+ N+ +L + YQ Y + + VA F+N + +Y E +L E Q +++ L
Sbjct: 1015 RQNLYEILSKIGHYQ-FPYNLQIVHQVATFVNKLPKYSEYDLNLLSESLQSQVNSPLAGV 1073
Query: 333 -PPSPVGSCAGSKESV 347
PS +G+ GS S+
Sbjct: 1074 YQPSLIGT-TGSSSSI 1088
>UniRef50_A2DCA8 Cluster: RasGEF domain containing protein; n=1;
Trichomonas vaginalis G3|Rep: RasGEF domain containing
protein - Trichomonas vaginalis G3
Length = 660
Score = 74.1 bits (174), Expect = 9e-12
Identities = 48/160 (30%), Positives = 76/160 (47%), Gaps = 3/160 (1%)
Query: 106 DVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNG 165
++ QLT + IK +EL W K APNV+A T+ +N+++ W IL+
Sbjct: 411 ELARQLTFWSYTRYYNIKRDELLDGAWEKPRLKYRAPNVIALTQHYNKLTSWVAHTILSE 470
Query: 166 QSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFD 225
Q+ + R E M I++ K L NN V+ L S +I+RL ++ ++ K+ +
Sbjct: 471 QNFRRRIEKMNKIIQLMKALFGDNNFLDGMGVLGGLGSNAIFRLKYHFSQIAIDRKEYLE 530
Query: 226 KLAELFGETDNWTALREYLKSISL---PCIPYLGIFLTDL 262
K+ + LR+ L P +PYLGI L DL
Sbjct: 531 KMEVQCSPDKGFLQLRKMQDEAVLNGKPALPYLGILLADL 570
>UniRef50_Q8X027 Cluster: Related to aimless RasGEF; n=2; Neurospora
crassa|Rep: Related to aimless RasGEF - Neurospora
crassa
Length = 985
Score = 74.1 bits (174), Expect = 9e-12
Identities = 59/245 (24%), Positives = 114/245 (46%), Gaps = 11/245 (4%)
Query: 98 SALRLSPDDVGNQLTLLDLPCFKAIKPEELT---TCGWTKLNKLTVAPNVVAFTKRFNRV 154
S + + PD + +++T +D F +I+ ++ + + K NV FN +
Sbjct: 724 SFMDIDPDIIADEITRIDWIMFSSIRIRDMVRHVSLPADQKEKCRSLKNVNRMVSHFNHI 783
Query: 155 SFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWA 214
+ W IL K RA + F+ +A++L LNN + L AV++ ++ +I+RL +T
Sbjct: 784 AQWVSNMILIRDKAKHRAPCLERFMVIAQRLRTLNNYNGLAAVLAGINGTAIHRLAQTRN 843
Query: 215 CLSKKDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYID-----IAH 269
+S +++F +L L G + A R ++ LP IP++ + DLV +
Sbjct: 844 LVSPDVQKRFARLVLLMGTQKSHFAYRLAWENTPLPRIPFIPLHRRDLVSAEEGSRTFVG 903
Query: 270 PAGSPHRVTKMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFV-EDDQYKLS 328
P K ++ + L S+ + P P++ S I +++ E+D Y+ S
Sbjct: 904 PNNDRINWKKYEVLGEVLLPIMRSQGQ--PYPNLTKHEPSRELILDMKMPTDEEDIYQRS 961
Query: 329 LKLEP 333
+++EP
Sbjct: 962 VQVEP 966
>UniRef50_Q59Z59 Cluster: Putative uncharacterized protein LTE1;
n=1; Candida albicans|Rep: Putative uncharacterized
protein LTE1 - Candida albicans (Yeast)
Length = 715
Score = 74.1 bits (174), Expect = 9e-12
Identities = 42/117 (35%), Positives = 62/117 (52%), Gaps = 2/117 (1%)
Query: 150 RFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRL 209
RFN + W + EIL QSP R +++ FI +A+ EL N +L +I AL S I +L
Sbjct: 509 RFNLMVNWIISEILLTQSPNERIHLISRFIHIAQHCLELQNFATLMQIILALTSQRIQKL 568
Query: 210 TKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSI--SLPCIPYLGIFLTDLVY 264
+TW L D L EL N+ +R + I S CIP++G++L+DL +
Sbjct: 569 KQTWKDLIPGDILLLKNLEELASPLKNFLNIRLTINQIKPSKGCIPFVGLYLSDLTF 625
>UniRef50_A6R1V9 Cluster: Putative uncharacterized protein; n=1;
Ajellomyces capsulatus NAm1|Rep: Putative
uncharacterized protein - Ajellomyces capsulatus NAm1
Length = 930
Score = 74.1 bits (174), Expect = 9e-12
Identities = 48/165 (29%), Positives = 80/165 (48%), Gaps = 3/165 (1%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAP---NVVAFTKRFNRVSFWT 158
+S D+ ++T +D F + +P EL + + NV +FN ++ +
Sbjct: 676 ISEDEFAREITRIDWVMFSSFRPRELVRHVSVSADDRASSKGLCNVNRMIDQFNHLALFV 735
Query: 159 VQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSK 218
+L PK RAE + F+ +A KL +LNN +SL AVI+ L+ ++RL++T +S
Sbjct: 736 ASMVLLRDKPKHRAEALEKFMNIAMKLRQLNNYNSLGAVIAGLNGTPVFRLSQTRELVSP 795
Query: 219 KDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLV 263
++QF L L G + A R + IP+L + DLV
Sbjct: 796 MVQKQFMSLVILMGTQKSHFAYRLAWDNSFAEKIPFLPLHRRDLV 840
>UniRef50_P34578 Cluster: Uncharacterized protein T20G5.5; n=2;
Caenorhabditis|Rep: Uncharacterized protein T20G5.5 -
Caenorhabditis elegans
Length = 1234
Score = 74.1 bits (174), Expect = 9e-12
Identities = 50/166 (30%), Positives = 79/166 (47%), Gaps = 4/166 (2%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELT--TCGWTKLNKLTVAPNVVAFTKRFNRVSFWTV 159
+ ++ +QL L L ++ EL G L++ N+ +RFN V W+
Sbjct: 990 IDSQELAHQLFLFHLQLLRSTDSNELLYQVIGRESF-PLSMPFNLDLLVRRFNEVQHWST 1048
Query: 160 QEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKK 219
EIL + + R EI+ FI +A E +L ++FA+ L SI RLT TW+ L
Sbjct: 1049 TEILLA-TEENRMEILKKFISIATIAREYRDLLTVFAITLGLSHTSISRLTLTWSKLPPA 1107
Query: 220 DKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYI 265
+ F +L L T N R + +S P IP++ + L DL++I
Sbjct: 1108 SLKTFSELENLLDPTRNHRMYRLLVSKMSSPYIPFVPLILKDLMFI 1153
>UniRef50_A2F7D3 Cluster: RasGEF domain containing protein; n=1;
Trichomonas vaginalis G3|Rep: RasGEF domain containing
protein - Trichomonas vaginalis G3
Length = 619
Score = 73.3 bits (172), Expect = 2e-11
Identities = 62/248 (25%), Positives = 108/248 (43%), Gaps = 15/248 (6%)
Query: 98 SALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFW 157
S + P + QLT+ + I+ EL W +PN+VA T +FN +S W
Sbjct: 369 SLFDIPPKEFARQLTVYACSKYYQIQRTELIDGAWASERSKHRSPNIVALTNQFNIISAW 428
Query: 158 TVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLS 217
IL S +AR M I ++L L N SLFA+ +S++I+RL + L
Sbjct: 429 VPTAILTEPSLQARLNKMKFLIDTMRELKALRNYFSLFAIHLGFNSSAIFRLQRHKKLLR 488
Query: 218 KKDKQQFDKLAELFGETDNWTALREYLK---SISLPCIPYLGIFLTDLVYIDIAHPAGSP 274
D +L +L + + L + K + P +P+L L+ L ++ A + +
Sbjct: 489 PDDVPFLKELEDLGSPSGAYHQLLQAHKEAINSGQPALPHLPPLLSFLFKVNEAIESLTT 548
Query: 275 HRVTKMN------IVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLS 328
+ + M +K +E + +Y + P+ V L ++ Y+E + +LS
Sbjct: 549 NGLINMKRCGRTFEFMKQIESFARRKYVLLPIEQVQQKLMNLEYME------GESLEELS 602
Query: 329 LKLEPPSP 336
+ +EP P
Sbjct: 603 IDVEPADP 610
>UniRef50_A3LVY6 Cluster: GDP/GTP exchange factor; n=2;
Saccharomycetaceae|Rep: GDP/GTP exchange factor - Pichia
stipitis (Yeast)
Length = 1235
Score = 73.3 bits (172), Expect = 2e-11
Identities = 40/117 (34%), Positives = 64/117 (54%), Gaps = 2/117 (1%)
Query: 150 RFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRL 209
RFN + W + EI+ ++ K R I++ FI +A+K + L N +L VI AL S + +L
Sbjct: 1027 RFNLMVNWIISEIILTKNQKERISIISRFIHIAQKCYTLQNFSTLMQVILALTSEKVQQL 1086
Query: 210 TKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSI--SLPCIPYLGIFLTDLVY 264
TW L+ D L EL N+ +R + + S CIP++G++L+DLV+
Sbjct: 1087 RYTWKNLAPGDILMLKNLEELSSPLKNFLNIRLCINHMKPSKGCIPFVGLYLSDLVF 1143
>UniRef50_UPI00005A1264 Cluster: PREDICTED: similar to Ral guanine
nucleotide dissociation stimulator (RalGEF) (RalGDS);
n=3; Canis lupus familiaris|Rep: PREDICTED: similar to
Ral guanine nucleotide dissociation stimulator (RalGEF)
(RalGDS) - Canis familiaris
Length = 357
Score = 72.9 bits (171), Expect = 2e-11
Identities = 44/120 (36%), Positives = 64/120 (53%), Gaps = 5/120 (4%)
Query: 104 PDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPN---VVAFTKRFNRVSFWTVQ 160
P V QLT +D FK ++P++ W+K N+ V A +FN V+ +
Sbjct: 238 PKLVAEQLTSIDADLFKKVQPQQCLGSIWSKRNEPGYEHRTCTVSATVTQFNNVANCVIT 297
Query: 161 EILNG--QSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSK 218
L + + RAE++ H+IKVAK L N SL A++SAL S SI+RL TWA +S+
Sbjct: 298 TCLGNARMTARDRAEVVEHWIKVAKACRTLRNYSSLHAILSALQSVSIHRLKNTWAKVSR 357
>UniRef50_Q752E6 Cluster: AFR630Cp; n=1; Eremothecium gossypii|Rep:
AFR630Cp - Ashbya gossypii (Yeast) (Eremothecium
gossypii)
Length = 1436
Score = 72.5 bits (170), Expect = 3e-11
Identities = 56/237 (23%), Positives = 113/237 (47%), Gaps = 27/237 (11%)
Query: 87 SINQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTT---CGWTKLNKLTVAPN 143
SI +++ + L+P +V QLTL++ + AIKP EL T C + ++ + A
Sbjct: 1135 SIFENFSQTTLNIAELNPIEVAKQLTLVESVMYLAIKPVELLTGDLCDRKRTDESSKART 1194
Query: 144 VVAFTKRFNRVSFWTVQEILN-GQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALH 202
++ FT N +S + + I+ G +AR + + ++K+A N +S+ ++++AL
Sbjct: 1195 ILNFT---NFLSQYVTESIIGPGFQLEARVDRLRGWLKIALSALYFRNFNSVASIMTALQ 1251
Query: 203 SASIYRLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSIS-------------- 248
S +I RL+ W L ++D+ F L+++ +N+ R L ++
Sbjct: 1252 SHAISRLSFIWESLDERDRDLFTYLSKIIHPNNNYKVYRIKLNKLAEDFVPTSLPTAKSP 1311
Query: 249 LPCIPYLGIFLTDLVYID-----IAHPAG-SPHRVTKMNIVLKALERYQSSEYEIAP 299
LP +P+ +F+ DL +I+ +P+ PH++ ++ + +Y P
Sbjct: 1312 LPVVPFFNLFIQDLTFINEGNCKFRNPSSFKPHKIVNIDKYFRITRTVSMLQYFQVP 1368
>UniRef50_UPI0000E485ED Cluster: PREDICTED: similar to Ral guanine
nucleotide dissociation stimulator,-like 1, partial;
n=1; Strongylocentrotus purpuratus|Rep: PREDICTED:
similar to Ral guanine nucleotide dissociation
stimulator,-like 1, partial - Strongylocentrotus
purpuratus
Length = 299
Score = 72.1 bits (169), Expect = 4e-11
Identities = 45/142 (31%), Positives = 74/142 (52%), Gaps = 4/142 (2%)
Query: 107 VGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLT-VAPNVVAFT-KRFNRVSFWTVQEILN 164
+ QLT ++ F+ + P+ W++ +K V P VA T +FN ++ + IL
Sbjct: 37 IAEQLTQMEADLFRKVIPQHCLGSIWSRRDKKHGVDPMTVAATVNQFNDITMKVMSTILE 96
Query: 165 GQS--PKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQ 222
+S P R I+ +I VA+ EL N +L A+ISAL S I+RL + W+ + K
Sbjct: 97 EKSLRPMTRGLIITKWIDVAQSCRELKNFSALKAIISALQSHPIHRLRRAWSSVPKASMV 156
Query: 223 QFDKLAELFGETDNWTALREYL 244
F+ LA +F + +N+ RE +
Sbjct: 157 LFEDLANIFLDDNNFETWREII 178
>UniRef50_UPI0000499FDF Cluster: Ras guanine nucleotide exchange
factor; n=1; Entamoeba histolytica HM-1:IMSS|Rep: Ras
guanine nucleotide exchange factor - Entamoeba
histolytica HM-1:IMSS
Length = 1284
Score = 72.1 bits (169), Expect = 4e-11
Identities = 57/243 (23%), Positives = 113/243 (46%), Gaps = 13/243 (5%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQE 161
+SP++V QLTL F +K EL W + +K + +++A T+ NRV
Sbjct: 342 MSPNEVSRQLTLKGYSLFSKVKVNELLL--WNEQDKESQCKSILALTQFSNRVVELFSNF 399
Query: 162 ILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDK 221
IL+ ++ K R +++ ++ + +L+N L + ++I+RL T+ +++K +
Sbjct: 400 ILSAKNLKHRIQLLEFVCQIGIEAEKLHNYDLLCCISFTFSKSAIHRLKCTFNGINEKYQ 459
Query: 222 QQFDKLAELFGETDNWTALREYLKSIS--LPCIPYLGIFLTDLVYIDIAHPAGSPHRVTK 279
Q +L ++ +NW LR + +PYLG FL+D+ +I+ + + + +
Sbjct: 460 QFIVRLKKISSPENNWQTLRNCTTQDENVIHALPYLGYFLSDVTFINDGNISTFGNGLIN 519
Query: 280 -------MNIVLKALERYQSSEYEIAPLPHVANFLNSV--RYIEELQKFVEDDQYKLSLK 330
MN+ K Q Y++ + L+ + L+ ++ +QY LS
Sbjct: 520 YLKCNMLMNVAQKVYHLQQIPYYDLVESISMQKALDKLLENMPTILESQIDKEQYLLSKL 579
Query: 331 LEP 333
+EP
Sbjct: 580 IEP 582
>UniRef50_Q4RPN7 Cluster: Chromosome 12 SCAF15007, whole genome
shotgun sequence; n=2; Tetraodontidae|Rep: Chromosome 12
SCAF15007, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 933
Score = 71.3 bits (167), Expect = 6e-11
Identities = 51/161 (31%), Positives = 86/161 (53%), Gaps = 10/161 (6%)
Query: 91 SWDDIV--CSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWT---KLNKLTVAPNVV 145
S+D I+ C + RL V L++ DL FK + P W+ K K +AP +
Sbjct: 332 SFDPIMVGCVSKRLIRS-VSGSLSVQDL--FKKVVPYHCLGGIWSQRDKKGKEHLAPTIR 388
Query: 146 AFTKRFNRVSFWTVQEILNGQS--PKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHS 203
A +FN V+ + L+ + P RA ++ +I VA++ L N SL A++SAL
Sbjct: 389 ATVAQFNSVTNCVITTCLSNPALKPNQRARLLERWIDVARECRILKNFSSLRAILSALQC 448
Query: 204 ASIYRLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYL 244
+I+RL +TW +S++ + F +L+E+F + +N++ RE L
Sbjct: 449 NAIHRLKRTWEEVSRESFRTFRELSEIFSDDNNYSLSRELL 489
>UniRef50_A2F534 Cluster: RasGEF domain containing protein; n=1;
Trichomonas vaginalis G3|Rep: RasGEF domain containing
protein - Trichomonas vaginalis G3
Length = 853
Score = 71.3 bits (167), Expect = 6e-11
Identities = 57/192 (29%), Positives = 95/192 (49%), Gaps = 16/192 (8%)
Query: 88 INQSWDDIVCSALRLSPDD--VGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVV 145
+N+ D + L S D V + L ++ I E C WTK NK AP+++
Sbjct: 592 LNEVKIDALKHTLAFSADSMTVAKHIMFNQLSTYRNINCREYVNCSWTK-NKH--APHLI 648
Query: 146 AFTKRFNRVSFWTVQEILN--GQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHS 203
T FN +S + I+N + PKA A I+A +I + +K +NN LF + SAL S
Sbjct: 649 EITTNFNHLSQYIQYTIVNFTKKDPKATAFIIAQWILIMEKCRIINNFQGLFVIESALSS 708
Query: 204 ASIYRLTKTWACLSKKDKQQFD-KLAELFGETD-NWTALREY--LKSISLP-----CIPY 254
S+ L K W L++ D K+ E++G + LR++ K++ + +P+
Sbjct: 709 PSVAGLHKCWDALNEITVPGSDLKIKEIYGALSLICSPLRKFKNYKTLLINIDESLALPF 768
Query: 255 LGIFLTDLVYID 266
+G +LTD+ +I+
Sbjct: 769 IGPWLTDMAFIN 780
>UniRef50_UPI00015B4D6B Cluster: PREDICTED: similar to ral guanine
nucleotide exchange factor, putative; n=1; Nasonia
vitripennis|Rep: PREDICTED: similar to ral guanine
nucleotide exchange factor, putative - Nasonia
vitripennis
Length = 849
Score = 70.9 bits (166), Expect = 8e-11
Identities = 43/144 (29%), Positives = 72/144 (50%), Gaps = 9/144 (6%)
Query: 110 QLTLLDLPCFKAIKPEELTTCGWTKLNKLTV--APNVVAFTKRFNRVSFWTVQEIL---- 163
QLT +D F+ + + W++ ++ A V+A +FN VS + +L
Sbjct: 372 QLTRMDAEVFRKLVAHQCLGAVWSRRDRSRSHDAATVLATVNQFNAVSLRVISSVLLCSG 431
Query: 164 ---NGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKD 220
+ P+ RA I+ +I +A++L L N SL A++S L S +YRL K W C+ ++
Sbjct: 432 AGGDEAKPQERARIIETWIDIAQELRILKNFSSLKAIVSGLQSNPVYRLEKCWQCVPREK 491
Query: 221 KQQFDKLAELFGETDNWTALREYL 244
+ F +L +F E +N RE L
Sbjct: 492 YEVFRELERIFSEENNAWTQRELL 515
Score = 37.9 bits (84), Expect = 0.73
Identities = 42/181 (23%), Positives = 71/181 (39%), Gaps = 4/181 (2%)
Query: 246 SISLPCIPYLGIFLTDLVYIDIAHP---AGSPHRVTKMNIVLKALERYQSSEYEIAPLPH 302
+IS IPYLG FLTDL ID A P A K + L R + +
Sbjct: 547 NISYGTIPYLGTFLTDLTMIDTAIPDTIAEGLINFDKRRKEFEVLARIRLLQGAANAYNF 606
Query: 303 VANFLNSVRYIEELQKFVEDDQYKLSLKLEPPSPVGSCAGSKESVKETVLQGNVTTFNIS 362
A+ L R+ + + + Y++S ++EPP P + K+ + + N +
Sbjct: 607 SADPLFD-RWFHSIVVLDDREAYRMSCQIEPPPPGSTINNRSAPPKKKHNHNHNHSNNHN 665
Query: 363 PSHKLGSGSLRLQGTSHQGKFIPTHRKCRSLGSNIFGKSHTEDKMDEKTPAGSVNLLDDT 422
S + S+ +S +F S N + + +M + + S+ LD +
Sbjct: 666 SSGHRKNDSIASTSSSSSSQFYCDLDSLPSSPHNSLDRRTSPSQMSSSSSSSSLPSLDIS 725
Query: 423 L 423
L
Sbjct: 726 L 726
>UniRef50_A2EE64 Cluster: RasGEF domain containing protein; n=2;
Trichomonas vaginalis G3|Rep: RasGEF domain containing
protein - Trichomonas vaginalis G3
Length = 468
Score = 70.9 bits (166), Expect = 8e-11
Identities = 44/204 (21%), Positives = 93/204 (45%), Gaps = 11/204 (5%)
Query: 104 PDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEIL 163
P + Q+ L D F AI P ++ C +L +P++ + F+ +S + ++
Sbjct: 230 PQQIALQIALQDSLIFGAISPRDVIACIGGQLTAKN-SPSISFLQEHFDTLSHFVAFSVI 288
Query: 164 NGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKT----WACLSKK 219
+ K RA + + ++ + +L ++N+ +F++ + S+ RL T W + K
Sbjct: 289 FEREVKVRATVYSMWVSILFELRKVNDFCGMFSIYGGITHPSVERLKSTIEEAWKTMGPK 348
Query: 220 DKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPHR--- 276
K++F+ + + +N+ R+ + PC+P+ G F D VY + +
Sbjct: 349 TKREFETIKNICSFNNNFHGYRQAVLISHPPCVPFFGCFQKDWVYFQEMNEFHTNDNKID 408
Query: 277 ---VTKMNIVLKALERYQSSEYEI 297
+ K + A+++YQ +YEI
Sbjct: 409 IPTIGKAYELYAAVQKYQKVKYEI 432
>UniRef50_UPI0000499915 Cluster: Ras guanine nucleotide exchange
factor; n=1; Entamoeba histolytica HM-1:IMSS|Rep: Ras
guanine nucleotide exchange factor - Entamoeba
histolytica HM-1:IMSS
Length = 824
Score = 70.5 bits (165), Expect = 1e-10
Identities = 56/233 (24%), Positives = 101/233 (43%), Gaps = 7/233 (3%)
Query: 104 PDDVGNQLTLLDLPCFKAIKPEEL--TTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQE 161
P ++ QLT++D +K +K EL K NK+ +V+ R + ++ WT
Sbjct: 585 PKEIARQLTMIDYGMYKKVKQSELLENLPSVMKRNKICRYSHVIEMVNRIDEIANWTATT 644
Query: 162 ILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDK 221
IL R +M FI+VA +L LNN HSL + ++ RL T + K
Sbjct: 645 ILMFADMNNRVAMMMKFIEVANELESLNNYHSLAGICKGFELETVQRLGITVKNVGSHLK 704
Query: 222 QQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSP--HRVTK 279
D L + ++ + ++ + C+P++ + D+ + P+ + + K
Sbjct: 705 HLTDISKNLGFNSGSFKGYKSAVEKVKDACVPFILPTIKDIHGVYEKQPSSGKIINTIQK 764
Query: 280 MNIVLKALE--RYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDD-QYKLSL 329
I+ A + +YQ+ EY + +L + Y+ + ED Q K+SL
Sbjct: 765 EQILELASKFLKYQNYEYGFTITDPLYTYLFDLCYLPVIGNPGEDSYQRKISL 817
>UniRef50_UPI0000498D55 Cluster: Ras guanine nucleotide exchange
factor; n=2; Entamoeba histolytica HM-1:IMSS|Rep: Ras
guanine nucleotide exchange factor - Entamoeba
histolytica HM-1:IMSS
Length = 830
Score = 70.5 bits (165), Expect = 1e-10
Identities = 58/234 (24%), Positives = 112/234 (47%), Gaps = 24/234 (10%)
Query: 106 DVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNG 165
D QLT + F++IK EL W K + ++ K FN + + +ILN
Sbjct: 218 DFSEQLTYITSYYFRSIKLFELFL--WNKCHD--ECKTLLKCIKVFNAIQNFFAIQILNK 273
Query: 166 QSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFD 225
++ R +I+ H I +A + L N + + ++S +++I+RL KT+ +S K +F+
Sbjct: 274 KNIFKRCKILQHIIDIAYYCYTLQNYNIVVCIVSLFSTSAIHRLHKTFNNISSLHKNKFN 333
Query: 226 KLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPHRV------TK 279
+L E E TA C+PY+G+FL+D+++ + ++ K
Sbjct: 334 ELIEKKLEEVKHTA-----------CVPYIGLFLSDMLFTTDGIKTQTEDKLINFIKCQK 382
Query: 280 MNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEP 333
++ + + + +Q Y P + +L + E++ E+D+++LS K+EP
Sbjct: 383 LSAIAQNVLSFQQKLYPFNANPILQKYLLIIFNANEIE---ENDKFELSRKIEP 433
>UniRef50_A4D140 Cluster: Rap guanine nucleotide exchange factor
(GEF) 5; n=4; Eutheria|Rep: Rap guanine nucleotide
exchange factor (GEF) 5 - Homo sapiens (Human)
Length = 444
Score = 70.5 bits (165), Expect = 1e-10
Identities = 48/182 (26%), Positives = 97/182 (53%), Gaps = 13/182 (7%)
Query: 160 QEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKK 219
QEIL R +++ FIK+A NL+S FA++ L++AS+ RL++TW + K
Sbjct: 266 QEILLCSQLGKRVQLVKKFIKIAAHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPGK 325
Query: 220 DKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPHRVT- 278
K+ F +L L + N A R+ K + P IP++ + L D+ +I + + V
Sbjct: 326 FKKLFSELESLTDPSLNHKAYRDAFKKMKPPKIPFMPLLLKDVTFIHEGNKTFLDNLVNF 385
Query: 279 -KMNIV---LKALERYQSSEY-EIAPLPH--VANFLNSVRYIEELQKFVEDDQYKLSLKL 331
K++++ ++ L +++++ +++P H + +++N + I+ Q ++LS ++
Sbjct: 386 EKLHMIADTVRTLRHCRTNQFGDLSPKEHQELKSYVNHLYVIDSQQAL-----FELSHRI 440
Query: 332 EP 333
EP
Sbjct: 441 EP 442
>UniRef50_Q4P292 Cluster: Putative uncharacterized protein; n=1;
Ustilago maydis|Rep: Putative uncharacterized protein -
Ustilago maydis (Smut fungus)
Length = 1853
Score = 70.5 bits (165), Expect = 1e-10
Identities = 73/278 (26%), Positives = 116/278 (41%), Gaps = 21/278 (7%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTV 159
+ + + + +LT L+ F AI+P +L +K P V FN +S W
Sbjct: 1587 MEVDDEIIATELTRLEWAFFTAIQPRDLLRHILVPHDKRD-GP-VSRSISHFNYISNWVC 1644
Query: 160 QEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACL-SK 218
IL K RA ++ F +A L NN SL +V+ L +++RL T L K
Sbjct: 1645 SMILAQSKTKHRARMLEKFFNIASILRHDNNYGSLNSVLGGLSKTAVHRLRHTRELLKGK 1704
Query: 219 KDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPA-----GS 273
+ + L L + A R L++ P IPY+G+ L D++ I +P+ G
Sbjct: 1705 AVNKAYQSLVRLMSNERSSAAYRLALENSDGPTIPYVGVHLQDIISISDGNPSKRASDGM 1764
Query: 274 PH--RVTKMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKL 331
H + + M+ + A+ R Q + I P V R I ++ ++ Y+ SL +
Sbjct: 1765 IHWRKFSLMDEAVMAVARCQQYDRYIKPNSAVE------RLIVDVPVMDDEALYERSLAV 1818
Query: 332 EPPSPVGSCAGSKESVKETVLQGNVTTFNISPSHKLGS 369
EP S AG V V G + SH+ S
Sbjct: 1819 EPRS-----AGGGGGVGVGVAAGKIKDLKTFLSHQASS 1851
>UniRef50_UPI00005A5919 Cluster: PREDICTED: similar to Ral guanine
nucleotide dissociation stimulator (RalGEF) (RalGDS);
n=5; Canis lupus familiaris|Rep: PREDICTED: similar to
Ral guanine nucleotide dissociation stimulator (RalGEF)
(RalGDS) - Canis familiaris
Length = 286
Score = 70.1 bits (164), Expect = 1e-10
Identities = 42/120 (35%), Positives = 64/120 (53%), Gaps = 5/120 (4%)
Query: 104 PDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLT---VAPNVVAFTKRFNRVSFWTVQ 160
P V QLT +D FK ++P++ W+K N+ + V A +FN V+ +
Sbjct: 167 PKLVAEQLTSIDADLFKKVQPQQCLGSIWSKRNEPGYEHLTCTVSATISQFNNVANCVIT 226
Query: 161 EILNG--QSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSK 218
L + + RA ++ H+IKVAK L N S+ A++SAL S SI+RL TWA +S+
Sbjct: 227 TCLGNAHMTARDRAVVVEHWIKVAKACQALRNYSSMHAILSALQSVSIHRLKNTWAKVSR 286
>UniRef50_UPI000049A114 Cluster: Ras guanine nucleotide exchange
factor; n=2; Entamoeba histolytica HM-1:IMSS|Rep: Ras
guanine nucleotide exchange factor - Entamoeba
histolytica HM-1:IMSS
Length = 970
Score = 69.7 bits (163), Expect = 2e-10
Identities = 45/161 (27%), Positives = 76/161 (47%), Gaps = 5/161 (3%)
Query: 111 LTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNGQSPKA 170
L +L F + EEL + K + PN+ +RFN + T+ N + PK
Sbjct: 763 LNSFNLVLFSRVTYEELIVMNYNKQENKPLTPNIQNMIERFNWIGS-TIVNCFN-ECPKG 820
Query: 171 -RAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFDKLAE 229
+A+ + I K+L +L ++H L +V+ L + + +S++DK ++ E
Sbjct: 821 DKAQFIQGLILFMKRLQQLKDIHFLVSVVYTLPRLDLDSIKSKK--ISEEDKNYLNETEE 878
Query: 230 LFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHP 270
L N+ LR YL + P IP++GI DL+ ID +P
Sbjct: 879 LCSFKQNYKYLRAYLSQLETPYIPFIGILSKDLMLIDEGNP 919
>UniRef50_Q2GV74 Cluster: Putative uncharacterized protein; n=1;
Chaetomium globosum|Rep: Putative uncharacterized protein
- Chaetomium globosum (Soil fungus)
Length = 1803
Score = 69.3 bits (162), Expect = 3e-10
Identities = 49/178 (27%), Positives = 81/178 (45%), Gaps = 7/178 (3%)
Query: 94 DIVCSALRLSPDDVGNQLTLLDL--PCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRF 151
DI+ L D N++ +L +K + + + W + T A V RF
Sbjct: 1552 DILAQQFTLVEKDALNEIDWKELIEMRWKNAEQKGIHVRSWVSFLRDTDARGVEVVIARF 1611
Query: 152 NRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTK 211
N + W + EI+ Q + RA + FI +A N ++ V AL S + RL
Sbjct: 1612 NIMVKWAISEIVLTQDMEERARCIIKFIHIAAHCRRYRNFATMSQVTIALTSNEVSRLNN 1671
Query: 212 TWACLSKKDKQQFDKLAELFGETDNWTALREYLK----SIS-LPCIPYLGIFLTDLVY 264
TWA + DK+ +L L T N+ +R ++ S+S + CIP++GI+ DL++
Sbjct: 1672 TWAMVPAGDKRTLTELEALLSPTRNFYNMRAEMEGGGASVSGMGCIPFVGIYTHDLLF 1729
>UniRef50_UPI000049940E Cluster: Ras guanine nucleotide exchange
factor; n=1; Entamoeba histolytica HM-1:IMSS|Rep: Ras
guanine nucleotide exchange factor - Entamoeba
histolytica HM-1:IMSS
Length = 1232
Score = 68.9 bits (161), Expect = 3e-10
Identities = 39/165 (23%), Positives = 75/165 (45%)
Query: 106 DVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNG 165
+V QLTL+ F I +E W+ + + NV+ + + V W + IL+
Sbjct: 998 EVARQLTLIASKIFNKIGRQEFFNKSWSDESLFPQSVNVIRMLRHSDTVRDWVISSILSF 1057
Query: 166 QSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFD 225
S + R + HFI++ L +LNN SL+ ++ AL + + K + +
Sbjct: 1058 FSTENRVKATIHFIQIGDYLMKLNNFQSLYGIVQALGPNGCISRLQVMDSIPSKYAKLYH 1117
Query: 226 KLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHP 270
+L + + +++ R+ + I+ P IP + FL D+ + +P
Sbjct: 1118 QLKKAVHDKNDYKNYRQIVSKINEPYIPLINAFLKDIEKFEDENP 1162
>UniRef50_UPI000065E24B Cluster: Rap guanine nucleotide exchange
factor 3 (cAMP-regulated guanine nucleotide exchange
factor I) (cAMP-GEFI) (Exchange factor directly
activated by cAMP 1) (Epac 1) (Rap1
guanine-nucleotide-exchange factor directly activated by
cAMP).; n=1; Takifugu rubripes|Rep: Rap guanine
nucleotide exchange factor 3 (cAMP-regulated guanine
nucleotide exchange factor I) (cAMP-GEFI) (Exchange
factor directly activated by cAMP 1) (Epac 1) (Rap1
guanine-nucleotide-exchange factor directly activated by
cAMP). - Takifugu rubripes
Length = 908
Score = 68.9 bits (161), Expect = 3e-10
Identities = 55/194 (28%), Positives = 86/194 (44%), Gaps = 25/194 (12%)
Query: 101 RLSPDDVGNQLTLLDLPCFKAIKPEELT--TCGWTKLNKLTVAPNVVAFTKRFNRVSFWT 158
++ D+ +LT D F A+ EL G K T A N+ F +RFN V W
Sbjct: 648 QMGSKDIATELTNYDWELFAAMHEAELIYYVFGRHKFPGATTA-NLERFVRRFNEVQHWV 706
Query: 159 VQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWA---- 214
V E+ + RA ++ FIK+A L E NL+S FAV+ L ++++ RL KTW
Sbjct: 707 VTELCLCEDLVKRAVLLKKFIKIASVLKEQKNLNSFFAVMFGLSNSAVRRLYKTWEVRAT 766
Query: 215 -----C-------------LSKKDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLG 256
C + K K+ + L + N A R + + P IP++
Sbjct: 767 AHVNWCPLQMFTLFGLFQRIPSKTKRIYCSYERLMDPSRNHRAYRLTVAKLGPPYIPFMP 826
Query: 257 IFLTDLVYIDIAHP 270
+ L D+ +I+ +P
Sbjct: 827 LLLKDMTFINEGNP 840
>UniRef50_Q9DE48 Cluster: Ras-associated protein; n=11;
Clupeocephala|Rep: Ras-associated protein - Danio rerio
(Zebrafish) (Brachydanio rerio)
Length = 359
Score = 68.9 bits (161), Expect = 3e-10
Identities = 43/144 (29%), Positives = 76/144 (52%), Gaps = 5/144 (3%)
Query: 107 VGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLT---VAPNVVAFTKRFNRVSFWTVQEIL 163
+ QLT ++ F + P W++ +K +V A K+FNR++ L
Sbjct: 205 IAEQLTRIETDLFLKLVPHHCLGSLWSQRDKKGQEGACWSVRATIKQFNRLANAVTASCL 264
Query: 164 NGQSPKA--RAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDK 221
+ K+ RA ++ +I VA+ N SL+A++SAL S I+RL KTW ++
Sbjct: 265 WMTTLKSQQRARLLEKWISVAEACRTRKNFSSLYAILSALQSNPIHRLRKTWQETDREAV 324
Query: 222 QQFDKLAELFGETDNWTALREYLK 245
+++++L+++F E DN++ RE LK
Sbjct: 325 KRYEELSDIFSEKDNYSQSRELLK 348
>UniRef50_Q5KPL7 Cluster: Ras guanyl-nucleotide exchange factor,
putative; n=2; Filobasidiella neoformans|Rep: Ras
guanyl-nucleotide exchange factor, putative -
Cryptococcus neoformans (Filobasidiella neoformans)
Length = 1023
Score = 68.9 bits (161), Expect = 3e-10
Identities = 50/173 (28%), Positives = 82/173 (47%), Gaps = 7/173 (4%)
Query: 77 YKTNSLPAACSINQS-WDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKL 135
Y+ NS+ + + + W + + +R+ P +LT + F I+P ++ L
Sbjct: 742 YRMNSMQVSDEVADARWGNALNMVMRMEPRVFATELTRMQWELFLDIRPRDVFR---HTL 798
Query: 136 NKLTVAPNVVAFTKRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLF 195
K T P V FN +S W +L K RA ++ FI +A +L LNN SL+
Sbjct: 799 GKETGGP-VRKSINFFNHLSRWISTIVLASSKAKHRARVIERFIFIAHQLRRLNNYDSLY 857
Query: 196 AVISALHSASIYRLTKTWAC--LSKKDKQQFDKLAELFGETDNWTALREYLKS 246
AVIS L AS++RL+ + A LS +Q + +L +T R+ L++
Sbjct: 858 AVISGLREASVHRLSASQALIQLSPIAEQDYHSHLKLMDPRSGYTQYRKALQA 910
>UniRef50_Q8SYL9 Cluster: RE54096p; n=4; Sophophora|Rep: RE54096p -
Drosophila melanogaster (Fruit fly)
Length = 691
Score = 68.1 bits (159), Expect = 6e-10
Identities = 38/116 (32%), Positives = 61/116 (52%), Gaps = 3/116 (2%)
Query: 131 GWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNN 190
G LN + N+ ++ + FNR+S+ T EI+ K R I+ ++I+ A++ + N
Sbjct: 437 GGGSLNDMKKTRNLESYVQWFNRLSYLTASEIVKYPKKKQRVRIIEYWIETARECFNIGN 496
Query: 191 LHSLFAVISALHSASIYRLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKS 246
+SL A+I+ L+ A I RL KTWA K +F L T N+ + R LK+
Sbjct: 497 FNSLMAIIAGLNLAPIGRLKKTWA---KVQSAKFSVLEHQMDPTSNFNSYRSTLKA 549
>UniRef50_A5DL36 Cluster: Putative uncharacterized protein; n=1;
Pichia guilliermondii|Rep: Putative uncharacterized
protein - Pichia guilliermondii (Yeast) (Candida
guilliermondii)
Length = 1287
Score = 68.1 bits (159), Expect = 6e-10
Identities = 44/164 (26%), Positives = 79/164 (48%), Gaps = 6/164 (3%)
Query: 150 RFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRL 209
RFN + W + EIL ++ R +++ FI +A+ + + N S+ ++ AL S I L
Sbjct: 1096 RFNLMVNWVISEILLTKAQSERIHLISRFIHIAQHCYAMQNYASMMQILLALTSEKIGHL 1155
Query: 210 TKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSI--SLPCIPYLGIFLTDLVYIDI 267
+TW L D L EL N+ +R + I S CIP++G++L+DL++ +
Sbjct: 1156 KETWKNLLPGDILSLKNLEELTSPVKNFLNIRLSINQIKPSKGCIPFVGLYLSDLIF-NA 1214
Query: 268 AHPAGSPHRVTKMNIVLKALERYQSSEYEIAPLPHVANFLNSVR 311
PA + + I R+++S Y + L + N+ +
Sbjct: 1215 ERPATIKSGLEEKMI---NFSRFRTSVYIVKSLSQCIEWSNNYK 1255
>UniRef50_A4QP96 Cluster: Putative uncharacterized protein; n=4;
Danio rerio|Rep: Putative uncharacterized protein -
Danio rerio (Zebrafish) (Brachydanio rerio)
Length = 472
Score = 67.7 bits (158), Expect = 8e-10
Identities = 67/215 (31%), Positives = 102/215 (47%), Gaps = 43/215 (20%)
Query: 167 SPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFDK 226
SP RA+I+ +I VA++ H+L N SL A++SAL S ++YRL KTWA +S++ F+
Sbjct: 33 SPTYRAKIIEKWISVAQECHQLRNFSSLRAILSALQSNAVYRLKKTWAVISRESMAVFEH 92
Query: 227 LAELFGETDNWTALREYL----------KSISLP--------C---------IPYLGIFL 259
L + F + + RE L +S S P C +PYLG +L
Sbjct: 93 LCDTFPDENCVLINREILVEEGNQAADVESHSAPKSPRLSPTCKHMSSSSGEVPYLGTYL 152
Query: 260 TDLVYIDIA---HPAGSPHRVTKMN---IVLKALERYQSS--EYEIAPLPHVANFLNSVR 311
T L +D A + G K +L + + Q+S Y + P + +++NS
Sbjct: 153 TILTMLDTALTDNVEGGLINFEKRRKEFEILSLIRQLQASCAHYTLQSHPRIISWINSSM 212
Query: 312 YIEELQKFVEDDQYKLSLKLEPPSPVGSCAGSKES 346
+ + QK Y+LS +LEP PV C S S
Sbjct: 213 SLSD-QK-----SYELSRELEP--PVDPCPSSPNS 239
>UniRef50_A5DX26 Cluster: Putative uncharacterized protein; n=1;
Lodderomyces elongisporus NRRL YB-4239|Rep: Putative
uncharacterized protein - Lodderomyces elongisporus
(Yeast) (Saccharomyces elongisporus)
Length = 1635
Score = 67.3 bits (157), Expect = 1e-09
Identities = 40/117 (34%), Positives = 58/117 (49%), Gaps = 2/117 (1%)
Query: 150 RFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRL 209
RFN + W + EI+ QS R I++ FI +A+ L N +L +I AL S I L
Sbjct: 1410 RFNLMVNWIISEIILTQSQTERINIISRFIHIAQNCLILQNFTTLMQIILALTSQRIQNL 1469
Query: 210 TKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSI--SLPCIPYLGIFLTDLVY 264
TW L D L EL N+ +R + I S CIP++G++L+DL +
Sbjct: 1470 RNTWRNLPPGDILMLKTLEELASPLKNFINIRLCINQITPSKGCIPFVGLYLSDLTF 1526
>UniRef50_A4R2V9 Cluster: Putative uncharacterized protein; n=1;
Magnaporthe grisea|Rep: Putative uncharacterized protein
- Magnaporthe grisea (Rice blast fungus) (Pyricularia
grisea)
Length = 1741
Score = 67.3 bits (157), Expect = 1e-09
Identities = 46/175 (26%), Positives = 75/175 (42%), Gaps = 5/175 (2%)
Query: 95 IVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRV 154
I+ L D N++ +L + K + W + T A V RFN +
Sbjct: 1493 ILAQQFTLIEKDALNEIDWKELIDMRWKKADNSDARSWVDFLRNTDARGVEVVIARFNIM 1552
Query: 155 SFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWA 214
W V EI+ Q + RA + FI +A N ++ + AL S + +L +TWA
Sbjct: 1553 VKWCVSEIVLTQDLEERARCLIKFIHIAAHCRRYRNFATMSQIAIALTSPEVSKLQRTWA 1612
Query: 215 CLSKKDKQQFDKLAELFGETDNWTALREYL-----KSISLPCIPYLGIFLTDLVY 264
+ D +L L T N+ LR + +S + CIP++GI+ DL++
Sbjct: 1613 MVPASDLTTLQQLEALVSPTRNFYNLRSEMEGGDVESANSGCIPFVGIYTHDLLF 1667
>UniRef50_Q0TX72 Cluster: Putative uncharacterized protein; n=1;
Phaeosphaeria nodorum|Rep: Putative uncharacterized
protein - Phaeosphaeria nodorum (Septoria nodorum)
Length = 1654
Score = 66.9 bits (156), Expect = 1e-09
Identities = 37/135 (27%), Positives = 65/135 (48%), Gaps = 2/135 (1%)
Query: 132 WTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNL 191
W + + A V RFN V W V E++ ++ RA + FI +A L N
Sbjct: 1440 WVQYLRTEEARGVDVVIARFNLVVKWVVSEVVLTENTHERARCIVKFIHIATHARRLRNY 1499
Query: 192 HSLFAVISALHSASIYRLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISLP- 250
+++ + AL S + +L KTWA + + +L + N+ LR +++ ++
Sbjct: 1500 ATMYQIAIALISNDVSKLRKTWALVPAAELHVMKELEGIVQPLKNFHNLRLEMETATVDD 1559
Query: 251 -CIPYLGIFLTDLVY 264
CIP++GI+ DL+Y
Sbjct: 1560 GCIPFIGIYTRDLIY 1574
>UniRef50_Q6C3H8 Cluster: Similar to CAGL0G06226g Candida glabrata
IPF 3446.1; n=1; Yarrowia lipolytica|Rep: Similar to
CAGL0G06226g Candida glabrata IPF 3446.1 - Yarrowia
lipolytica (Candida lipolytica)
Length = 906
Score = 66.5 bits (155), Expect = 2e-09
Identities = 37/117 (31%), Positives = 63/117 (53%), Gaps = 2/117 (1%)
Query: 150 RFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRL 209
RFN V W + EIL + R +++ FI +A E+ N +L ++ AL S+ + RL
Sbjct: 719 RFNLVVNWVISEILLTKRLAERICVVSRFIHIAFLCREMQNFATLMQIVLALSSSHVSRL 778
Query: 210 TKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSI--SLPCIPYLGIFLTDLVY 264
+TW + +DK+ +L ++ N+ LR+ SI CIP++G+ L+DL +
Sbjct: 779 KETWQHILPQDKKILAELEQIVVPLKNFHNLRQEFVSIDPEKGCIPFVGLSLSDLTF 835
>UniRef50_P07866 Cluster: Guanine nucleotide exchange factor LTE1;
n=3; cellular organisms|Rep: Guanine nucleotide exchange
factor LTE1 - Saccharomyces cerevisiae (Baker's yeast)
Length = 1435
Score = 66.1 bits (154), Expect = 2e-09
Identities = 32/115 (27%), Positives = 61/115 (53%), Gaps = 2/115 (1%)
Query: 150 RFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRL 209
RFN W + EIL +S K + ++ FI VA N ++L +I AL S+ + +
Sbjct: 1252 RFNLTVDWIISEILLTKSSKMKRNVIQRFIHVADHCRTFQNFNTLMEIILALSSSVVQKF 1311
Query: 210 TKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSIS--LPCIPYLGIFLTDL 262
T W + D +++L ++ N++ +R L S++ + C+P++ ++L+DL
Sbjct: 1312 TDAWRLIEPGDLLTWEELKKIPSLDRNYSTIRNLLNSVNPLVGCVPFIVVYLSDL 1366
>UniRef50_Q873I0 Cluster: Related to LTE1 protein; n=2; Neurospora
crassa|Rep: Related to LTE1 protein - Neurospora crassa
Length = 1792
Score = 65.3 bits (152), Expect = 4e-09
Identities = 40/138 (28%), Positives = 64/138 (46%), Gaps = 5/138 (3%)
Query: 132 WTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNL 191
W + T A V RFN + W + EI+ + + RA + I +A N
Sbjct: 1581 WVSFLRDTDAHGVEVVIARFNIMVKWAISEIVLTRDIEERARCIIKLIHIAAHCRRFRNF 1640
Query: 192 HSLFAVISALHSASIYRLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYL-----KS 246
++ + AL S I RL KTWA + D++ +L L T N+ LR+ + K+
Sbjct: 1641 ATMAQLTIALMSNEIGRLNKTWAMVPSSDQRTMQELETLMSPTRNFYNLRKEMEGGDSKT 1700
Query: 247 ISLPCIPYLGIFLTDLVY 264
CIP++GI+ DL++
Sbjct: 1701 ADEGCIPFVGIYTHDLLF 1718
>UniRef50_Q6UNM9 Cluster: LTE1-like protein; n=1; Epichloe
festucae|Rep: LTE1-like protein - Epichloe festucae
Length = 1672
Score = 65.3 bits (152), Expect = 4e-09
Identities = 49/177 (27%), Positives = 75/177 (42%), Gaps = 12/177 (6%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELT-------TCG----WTKLNKLTVAPNVVAFT 148
L D + Q TL++ I ELT C W + A V
Sbjct: 1422 LAFDSDVLAQQFTLIEKDALTEIDWRELTDMSWKHFACSDSRSWVDFLRNIDAQGVDVVI 1481
Query: 149 KRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYR 208
RFN + W + EI+ Q + RA + I +A N +L + AL S + R
Sbjct: 1482 ARFNIMVKWAISEIVLTQQVEERARCIIKLIHIAAHCRRYRNFATLAQLTIALSSNEVSR 1541
Query: 209 LTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLK-SISLPCIPYLGIFLTDLVY 264
L+KTW + ++D Q L L + N+ +RE ++ CIP++GI+ DL+Y
Sbjct: 1542 LSKTWELVPERDLQTLHDLEILVTPSRNFHNIREEMEVGTDRGCIPFVGIYTHDLLY 1598
>UniRef50_Q19852 Cluster: Putative uncharacterized protein F28B4.2;
n=2; Caenorhabditis|Rep: Putative uncharacterized
protein F28B4.2 - Caenorhabditis elegans
Length = 860
Score = 64.9 bits (151), Expect = 6e-09
Identities = 42/131 (32%), Positives = 67/131 (51%), Gaps = 3/131 (2%)
Query: 107 VGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFT-KRFNRVSFWTVQEI-LN 164
+ QLT D FK + + C W+K V T ++FN VS + I L
Sbjct: 238 IAEQLTFWDAALFKELLIHQCQGCVWSKRRTAGERVYTVKATIEQFNSVSQRVMTSIVLP 297
Query: 165 GQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQF 224
P+ RA+I++ +I +A++L L N SL AV+S+L S ++RL W + + QF
Sbjct: 298 DCRPEYRAKIISKWIDIARELRALKNFSSLKAVLSSLQSEPVHRLKSAWNSVPNRSISQF 357
Query: 225 DKLAELFGETD 235
+L+ ++ ETD
Sbjct: 358 RELSSIY-ETD 367
>UniRef50_Q5T7U6 Cluster: Ral guanine nucleotide dissociation
stimulator; n=29; Euteleostomi|Rep: Ral guanine
nucleotide dissociation stimulator - Homo sapiens
(Human)
Length = 309
Score = 64.5 bits (150), Expect = 7e-09
Identities = 59/184 (32%), Positives = 85/184 (46%), Gaps = 38/184 (20%)
Query: 188 LNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYL--- 244
L N SL+A++SAL S SI+RL KTW +S+ + F KL+E+F + +N++ RE L
Sbjct: 36 LKNFSSLYAILSALQSNSIHRLKKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKE 95
Query: 245 ---------------------KSISLPCIPYLGIFLTDLVYIDIAHPAGSPHRV------ 277
I +PYLG FLTDLV +D A R+
Sbjct: 96 GTSKFATLEMNPKRAQKRPKETGIIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKR 155
Query: 278 TKMNIVLKALERYQS--SEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEPPS 335
K V+ ++ QS + Y IAP + +V ++ E + Y LS +LEPPS
Sbjct: 156 RKEFEVIAQIKLLQSACNNYSIAPDEQFGAWFRAV------ERLSETESYNLSCELEPPS 209
Query: 336 PVGS 339
S
Sbjct: 210 ESAS 213
>UniRef50_A7F2T0 Cluster: Putative uncharacterized protein; n=1;
Sclerotinia sclerotiorum 1980|Rep: Putative
uncharacterized protein - Sclerotinia sclerotiorum 1980
Length = 1721
Score = 64.5 bits (150), Expect = 7e-09
Identities = 40/137 (29%), Positives = 62/137 (45%), Gaps = 2/137 (1%)
Query: 129 TCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHEL 188
T W + + + V RFN + W V EI+ + R + +I +A +
Sbjct: 1509 TRSWVEFLRSSEPRGVEVVIARFNIMVKWAVSEIVLTGDLEERVRCIIKYIHIAVNCRKY 1568
Query: 189 NNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSIS 248
N ++ + AL S I RLT TWA + D Q +L EL T N+ LR ++
Sbjct: 1569 RNFATMTQLTVALTSKDISRLTSTWAHVPASDIQTLHELEELVTPTSNFHNLRAEMEGCG 1628
Query: 249 LP--CIPYLGIFLTDLV 263
CIP++GI+ DL+
Sbjct: 1629 ADRGCIPFVGIYTHDLI 1645
>UniRef50_A6RN08 Cluster: Putative uncharacterized protein; n=2;
Pezizomycotina|Rep: Putative uncharacterized protein -
Botryotinia fuckeliana B05.10
Length = 370
Score = 64.1 bits (149), Expect = 1e-08
Identities = 40/137 (29%), Positives = 62/137 (45%), Gaps = 2/137 (1%)
Query: 129 TCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHEL 188
T W + + V RFN + W V EI+ + R + +I +A +
Sbjct: 158 TRSWVDFLRSSEPRGVEVVIARFNIMVKWAVSEIVLTGDLEERVRCIIKYIHIAVNCRKY 217
Query: 189 NNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSIS 248
N ++ + AL S I RLT TWA + D Q ++L EL T N+ LR ++
Sbjct: 218 RNFATMTQLTVALTSKDISRLTSTWAHVPASDIQTLNELEELVTPTSNFHNLRAEMEGSG 277
Query: 249 LP--CIPYLGIFLTDLV 263
CIP++GI+ DL+
Sbjct: 278 ADQGCIPFVGIYTHDLI 294
>UniRef50_A7S186 Cluster: Predicted protein; n=1; Nematostella
vectensis|Rep: Predicted protein - Nematostella
vectensis
Length = 465
Score = 63.7 bits (148), Expect = 1e-08
Identities = 35/120 (29%), Positives = 67/120 (55%), Gaps = 1/120 (0%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQE 161
++P + ++T++D AI EE+T ++K+ +P+VV +N ++ T E
Sbjct: 75 IAPRAMAEEITMIDSEMLSAIGYEEVTGGALMSIDKVK-SPHVVQMIDFYNSIAAITATE 133
Query: 162 ILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDK 221
+L + + RA +++ I++A + + NN +S A++S L +I RLTKTW + +K K
Sbjct: 134 VLVKEGSRDRAYVISRVIQMADECVDFNNFNSAKALMSGLRYVAITRLTKTWKKVPEKHK 193
>UniRef50_A6R8M8 Cluster: Predicted protein; n=1; Ajellomyces
capsulatus NAm1|Rep: Predicted protein - Ajellomyces
capsulatus NAm1
Length = 1705
Score = 63.7 bits (148), Expect = 1e-08
Identities = 35/117 (29%), Positives = 59/117 (50%), Gaps = 2/117 (1%)
Query: 150 RFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRL 209
RFN + W V E++ ++ RA + I VA L N ++ + AL S RL
Sbjct: 1514 RFNLMVKWVVSEVVLTKNITERARTITKLIHVAVHSRRLRNYSTMLQITIALCSVDCTRL 1573
Query: 210 TKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISLP--CIPYLGIFLTDLVY 264
TKTW ++ +KQ + L N+ LR +++ +L C+P++G+++ DL Y
Sbjct: 1574 TKTWELVADDEKQLLKDMETLAQPIRNFQKLRLEMETTNLQDGCVPFVGLYVQDLTY 1630
>UniRef50_Q6CY10 Cluster: Guanine nucleotide exchange factor LTE1;
n=1; Kluyveromyces lactis|Rep: Guanine nucleotide
exchange factor LTE1 - Kluyveromyces lactis (Yeast)
(Candida sphaerica)
Length = 1366
Score = 63.7 bits (148), Expect = 1e-08
Identities = 32/115 (27%), Positives = 60/115 (52%), Gaps = 2/115 (1%)
Query: 150 RFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRL 209
RFN W + EI+ Q + R + FI +A+ EL N ++L +I AL+S + +
Sbjct: 1179 RFNLTVDWIISEIVMTQDIRLRRNTIQRFIHIAEHCKELQNYNTLMEIILALNSIVVQKF 1238
Query: 210 TKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSIS--LPCIPYLGIFLTDL 262
T+TW + D ++ L + N++ +R+ + + CIP++ ++L+DL
Sbjct: 1239 TETWRLVEPGDLLTWETLKAIPSLEKNYSNIRQLIDEVEPLSGCIPFIVVYLSDL 1293
>UniRef50_Q6FT12 Cluster: Guanine nucleotide exchange factor LTE1;
n=1; Candida glabrata|Rep: Guanine nucleotide exchange
factor LTE1 - Candida glabrata (Yeast) (Torulopsis
glabrata)
Length = 1318
Score = 63.7 bits (148), Expect = 1e-08
Identities = 48/179 (26%), Positives = 84/179 (46%), Gaps = 13/179 (7%)
Query: 150 RFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRL 209
RFN W + EI+ K R + FI VA+ +L N +++ +I AL+S + +
Sbjct: 1131 RFNLTVDWAISEIVLTTDLKMRRNTIERFIHVAEHCRKLQNFNTMMQIILALNSVVVQKF 1190
Query: 210 TKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSIS--LPCIPYLGIFLTDLVYIDI 267
T+ W + D ++ L ++ N+ ALR +K++ CIP++ ++L+DL
Sbjct: 1191 TEAWRLIEPGDMLLWEDLRKIPALDWNYHALRTMMKTVDPLKGCIPFIVVYLSDLTINSE 1250
Query: 268 AHPAGSPHRV-------TKMNIVLKALERYQ-SSEYEIAPLPHVANFLNSVRYIEELQK 318
+ RV T + IV +++ Q SS Y+I P + L+ YI L +
Sbjct: 1251 KNTWIVEKRVVNYSKFSTCVQIVKNFIQKVQWSSFYDIIP---IQELLSKCIYISSLSQ 1306
>UniRef50_Q54F62 Cluster: RasGEF domain-containing protein; n=2;
Dictyostelium discoideum|Rep: RasGEF domain-containing
protein - Dictyostelium discoideum AX4
Length = 2631
Score = 63.3 bits (147), Expect = 2e-08
Identities = 45/154 (29%), Positives = 75/154 (48%), Gaps = 11/154 (7%)
Query: 104 PDDVGNQLTLLDLPCFKAIKPEELT--TCGWTKLN---------KLTVAPNVVAFTKRFN 152
P+ + Q T L+L + I P EL + G N + + P++ + + FN
Sbjct: 1709 PELIARQYTFLELKYLQNIHPRELLGFSVGLVMPNENEKDPEKWRQSNFPHIYDYFRWFN 1768
Query: 153 RVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKT 212
+++ EIL + K RA I+ +I +A + L N + + V+S+LHS I RL+ T
Sbjct: 1769 KMTMLVSTEILRQRDIKQRASIIEKYISIALEYLSLWNFNGIMQVLSSLHSEPISRLSAT 1828
Query: 213 WACLSKKDKQQFDKLAELFGETDNWTALREYLKS 246
WA +S++ F +L+ L N+ LR L S
Sbjct: 1829 WAKVSQRSMDCFYELSRLMLPESNYLPLRTALAS 1862
>UniRef50_Q8N431 Cluster: Ras-GEF domain-containing family member
1C; n=57; Euteleostomi|Rep: Ras-GEF domain-containing
family member 1C - Homo sapiens (Human)
Length = 466
Score = 62.9 bits (146), Expect = 2e-08
Identities = 38/118 (32%), Positives = 59/118 (50%), Gaps = 7/118 (5%)
Query: 104 PDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAP-------NVVAFTKRFNRVSF 156
P + QLT ++L + I PEE K + P N+ A+ K FNR+ +
Sbjct: 201 PYTLAQQLTHVELERLRHIGPEEFVQAFVNKDPLASTKPCFSDKTSNLEAYVKWFNRLCY 260
Query: 157 WTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWA 214
EI K RA+++ FI VA++ + N +SL A+IS ++ + + RL KTWA
Sbjct: 261 LVATEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWA 318
>UniRef50_UPI00004996D1 Cluster: Ras guanine nucleotide exchange
factor; n=1; Entamoeba histolytica HM-1:IMSS|Rep: Ras
guanine nucleotide exchange factor - Entamoeba
histolytica HM-1:IMSS
Length = 1430
Score = 62.1 bits (144), Expect = 4e-08
Identities = 56/274 (20%), Positives = 125/274 (45%), Gaps = 21/274 (7%)
Query: 104 PDDVGNQLTLLDLPCFKAIKPEEL--TTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQE 161
P + Q+TL F+ IK E +T TK N+ N++ T +N +
Sbjct: 288 PLEFAKQITLFTSELFRKIKLVEFFKSTSNTTK-NECF---NIIEMTNFYNAFQNCLTEL 343
Query: 162 ILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDK 221
IL + R+ I+ +A +LNN + +++ +++++RL +T+ +S +
Sbjct: 344 ILGQNDLQKRSLIVERLDLIAYYCLQLNNFFIVVCIVTLFETSALHRLKRTFKAVSNDVQ 403
Query: 222 QQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPH------ 275
++F+ + ++ NW +LR + + +P+LG+ L+DL++ + + +
Sbjct: 404 EKFETVRKVANMEGNWKSLRVAEDNCTAAMVPFLGLILSDLLFTNDGNKTITSDSTINFA 463
Query: 276 RVTKMNIVLKALERYQSSEYEIAPL---PHVANFLNSVRYIEELQKFVEDD--QYKLSLK 330
+ K++ ++ + R Q Y L + ++ +++ E ++K D QY +S +
Sbjct: 464 KCRKLSDIVVTINRIQQLSYGSKILKSEEYQTYIIDKIQHGEFVEKKPGSDSLQYNISKQ 523
Query: 331 LEPPSPVGSCAGSKESVKETVLQGNVTTFNISPS 364
LE V C + +E + G+++ + P+
Sbjct: 524 LE----VSDCVTQEVFTQEEIPDGHLSISVVLPN 553
>UniRef50_A7TSP6 Cluster: Putative uncharacterized protein; n=1;
Vanderwaltozyma polyspora DSM 70294|Rep: Putative
uncharacterized protein - Vanderwaltozyma polyspora DSM
70294
Length = 1371
Score = 62.1 bits (144), Expect = 4e-08
Identities = 33/115 (28%), Positives = 58/115 (50%), Gaps = 2/115 (1%)
Query: 150 RFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRL 209
RFN V W V EI+ K + ++ +I VA + N +S+ +I AL+S++I +
Sbjct: 1185 RFNLVVDWIVSEIVLTTDTKLKRNVIQRYIHVADHCKRMQNYNSMMQIILALNSSTIQKY 1244
Query: 210 TKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSIS--LPCIPYLGIFLTDL 262
+TW + D + +L + N +R L S+ CIP++ ++L+DL
Sbjct: 1245 IETWRLIEPGDLLTWQELKSIPSLDKNHNTVRSLLNSVDPLKGCIPFIVVYLSDL 1299
>UniRef50_Q95S44 Cluster: GM09415p; n=4; Sophophora|Rep: GM09415p -
Drosophila melanogaster (Fruit fly)
Length = 709
Score = 61.7 bits (143), Expect = 5e-08
Identities = 60/236 (25%), Positives = 102/236 (43%), Gaps = 32/236 (13%)
Query: 122 IKPEELTTC-GWTKLNKL----TVAPNVVAFTKRFNRVSFWTVQEILNGQSPKARAEIMA 176
++ +EL TC TK L + ++ + FN++S+ T EIL RA+++
Sbjct: 463 LEKDELKTCISQTKAGTLGSNCISQVTIDSYVQWFNQLSYLTATEILKLGKKSQRAQMID 522
Query: 177 HFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFDKLAELFGETDN 236
+++ A + N +SL A+++AL+ +I RL KTWA K +F+ L + N
Sbjct: 523 FWVETALECFNTGNFNSLMAILTALNLTAIARLKKTWA---KVQTTKFEGLEHQMDPSSN 579
Query: 237 ------------WTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPH------RVT 278
W + RE I IP+ +FL DL I+ +H + +
Sbjct: 580 FLNYRSTMKAAVWRSEREMANEIERAIIPFFSLFLKDLHAINESHETKLANGYINFEKCL 639
Query: 279 KMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEPP 334
+ L+ ++Q + LP V V Y+ + + ED K S + EPP
Sbjct: 640 HLGTQLRNFGKWQRLDCPYEQLPSV------VSYLLKAEVLSEDLLMKASYESEPP 689
>UniRef50_Q1E205 Cluster: Putative uncharacterized protein; n=1;
Coccidioides immitis|Rep: Putative uncharacterized
protein - Coccidioides immitis
Length = 1647
Score = 61.7 bits (143), Expect = 5e-08
Identities = 37/139 (26%), Positives = 62/139 (44%), Gaps = 2/139 (1%)
Query: 128 TTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHE 187
TT W + RFN + W + +I+ + RA + I VA
Sbjct: 1435 TTLNWVNYLADQDRKGIDMVVARFNLMVKWALSQIVMTTNRALRASTITKLIHVAVYSRR 1494
Query: 188 LNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSI 247
+ N ++ + AL S RL KTW + +KQ ++ L T N+ LR +++
Sbjct: 1495 IRNYATMLQMTIALCSIDCTRLVKTWELVPDGEKQLLKEMERLIQPTRNFHNLRSEMETC 1554
Query: 248 SLP--CIPYLGIFLTDLVY 264
+L CIP++G+++ DL Y
Sbjct: 1555 NLQEGCIPFVGLYVQDLTY 1573
>UniRef50_UPI000049A3F6 Cluster: Ras guanine nucleotide exchange
factor; n=1; Entamoeba histolytica HM-1:IMSS|Rep: Ras
guanine nucleotide exchange factor - Entamoeba
histolytica HM-1:IMSS
Length = 874
Score = 61.3 bits (142), Expect = 7e-08
Identities = 41/121 (33%), Positives = 64/121 (52%), Gaps = 7/121 (5%)
Query: 150 RFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRL 209
R N +S WT +L+ ++RA + HFI++ KKL EL + +S F + L SI
Sbjct: 694 RINDLSNWTCNSVLSFTDFESRAFMKNHFIEILKKLQELGDFNSAFGIFDGLLHISIVFG 753
Query: 210 TKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAH 269
TK +S+K + D+ ++L+G N+ +L+ K SL CIPY+G L + I
Sbjct: 754 TK---YISEKANKFIDETSKLYG---NFKSLKVAYKKHSL-CIPYIGSVLESIEEIKREE 806
Query: 270 P 270
P
Sbjct: 807 P 807
>UniRef50_A7SDN8 Cluster: Predicted protein; n=4; Eumetazoa|Rep:
Predicted protein - Nematostella vectensis
Length = 133
Score = 61.3 bits (142), Expect = 7e-08
Identities = 39/118 (33%), Positives = 58/118 (49%), Gaps = 4/118 (3%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKL-TVAPNVVAFTKRFNRVSFWT 158
L + P+ QLT++D F+ + W++ + A V A +FN VS
Sbjct: 3 LSIEPEKFAEQLTIMDAELFRKVIAWHCMGSVWSRRKRSHKPAFTVQATVDQFNAVSLKV 62
Query: 159 VQEILN---GQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTW 213
+ IL +SP R + +I +A+ L N SL A+ISAL SASI+RL K+W
Sbjct: 63 LSSILRTPENKSPAQRGRYINQWINIAQCCRNLKNFSSLKAIISALQSASIHRLKKSW 120
>UniRef50_UPI000049A05E Cluster: Ras guanine nucleotide exchange
factor; n=1; Entamoeba histolytica HM-1:IMSS|Rep: Ras
guanine nucleotide exchange factor - Entamoeba
histolytica HM-1:IMSS
Length = 440
Score = 60.1 bits (139), Expect = 2e-07
Identities = 38/162 (23%), Positives = 79/162 (48%), Gaps = 11/162 (6%)
Query: 106 DVGNQLTLLDLPCFKAIKPEE--LTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEIL 163
++ NQL + + + ++P++ + T+ N N+ + K +++ W I+
Sbjct: 204 EIANQLMICEFSFLELLQPKDYYINIFSTTRPNS-----NIELYYKWNQKITNWVAYSII 258
Query: 164 NGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQ 223
N ++ R +F+++A K E+ N +S ++++ L ++ R+ KT A ++++ +
Sbjct: 259 NQKNEMIREMAFKNFLQLAIKCIEIKNFNSFNSIVNGLTHYAVIRMKKTIAQRTQEENEL 318
Query: 224 FDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYI 265
KL ++ GE N Y S P IPYL FL ++ I
Sbjct: 319 MFKLIDIQGEIQN----SNYSISYGKPAIPYLKFFLKEMCQI 356
>UniRef50_Q4S5W0 Cluster: Chromosome 9 SCAF14729, whole genome
shotgun sequence; n=1; Tetraodon nigroviridis|Rep:
Chromosome 9 SCAF14729, whole genome shotgun sequence -
Tetraodon nigroviridis (Green puffer)
Length = 980
Score = 60.1 bits (139), Expect = 2e-07
Identities = 30/85 (35%), Positives = 46/85 (54%)
Query: 140 VAPNVVAFTKRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVIS 199
V N+ F +RFN V W ++ RA ++ FIK+A L E NL+S FAV+
Sbjct: 679 VTANLERFVRRFNEVQHWVATDLCLCTDLVKRALLLKKFIKIAAVLKEQKNLNSFFAVMF 738
Query: 200 ALHSASIYRLTKTWACLSKKDKQQF 224
L ++++ RL KTW + K K+ +
Sbjct: 739 GLSNSAVRRLHKTWERIPSKTKRVY 763
>UniRef50_Q5B8N8 Cluster: Putative uncharacterized protein; n=1;
Emericella nidulans|Rep: Putative uncharacterized protein
- Emericella nidulans (Aspergillus nidulans)
Length = 1635
Score = 59.7 bits (138), Expect = 2e-07
Identities = 49/183 (26%), Positives = 84/183 (45%), Gaps = 16/183 (8%)
Query: 150 RFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRL 209
RFN + W + EI+ K RA ++ FI A + N ++ + AL S RL
Sbjct: 1445 RFNLMVKWALSEIVLTLDIKERALTISKFIHTAVHARRMCNYATMLQICIALTSTDCSRL 1504
Query: 210 TKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISLP--CIPYLGIFLTDLVYIDI 267
TWA + +D++ L L N+ LR +++ ++ CIP++G+++ DL Y +
Sbjct: 1505 QSTWALVPLEDRRMLKDLEMLIQPVRNFHDLRVEMETANVQEGCIPFVGLYIHDLTY-NA 1563
Query: 268 AHPA-------GSP----HRVTKMNIVLKALERY--QSSEYEIAPLPHVANFLNSVRYIE 314
PA G P R ++K+L R S++Y I P+P + + + +
Sbjct: 1564 QKPAQVAATREGEPLINFERYRTTARIVKSLLRLIDASTKYNIEPVPGIVERVLWIASLS 1623
Query: 315 ELQ 317
E Q
Sbjct: 1624 EEQ 1626
>UniRef50_UPI0000F20A79 Cluster: PREDICTED: hypothetical protein,
partial; n=1; Danio rerio|Rep: PREDICTED: hypothetical
protein, partial - Danio rerio
Length = 217
Score = 59.3 bits (137), Expect = 3e-07
Identities = 35/106 (33%), Positives = 59/106 (55%)
Query: 142 PNVVAFTKRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISAL 201
P + F FN VS W +L+ + + RA +++ FIKVA++L +L N ++L AV+ L
Sbjct: 64 PILERFITLFNSVSQWIQIMVLSKPTAQQRATVISEFIKVAERLLQLQNFNTLMAVVGGL 123
Query: 202 HSASIYRLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSI 247
++SI RL T A +S +++ + ET ++A LK+I
Sbjct: 124 SNSSIARLKNTQALISSDTRKRSEYRESCSPETRAYSADWARLKTI 169
>UniRef50_UPI000049982C Cluster: hypothetical protein 82.t00013;
n=1; Entamoeba histolytica HM-1:IMSS|Rep: hypothetical
protein 82.t00013 - Entamoeba histolytica HM-1:IMSS
Length = 894
Score = 59.3 bits (137), Expect = 3e-07
Identities = 38/130 (29%), Positives = 61/130 (46%), Gaps = 3/130 (2%)
Query: 137 KLTVAPNVVAFTKRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFA 196
K T PN+ T FN +S T+ ++ S ++ +K A++ +E N L A
Sbjct: 710 KPTATPNIKFMTTSFNWLSE-TLSSMIKDCSMSFQSAFFNFIMKTAERFYEQRNFFGLCA 768
Query: 197 VISALHSASIYRLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLG 256
++ ALH + K+ LSK+ + +K L DN+ ALR + P IP++G
Sbjct: 769 IVFALHKIQDFDYLKS--NLSKETQVSIEKFDVLCSFNDNYKALRTEISKSQTPLIPFIG 826
Query: 257 IFLTDLVYID 266
I DL+ D
Sbjct: 827 ILTKDLLVGD 836
>UniRef50_Q28EC1 Cluster: Ras-GEF domain-containing family member
1B; n=5; Coelomata|Rep: Ras-GEF domain-containing family
member 1B - Xenopus tropicalis (Western clawed frog)
(Silurana tropicalis)
Length = 472
Score = 58.8 bits (136), Expect = 4e-07
Identities = 34/103 (33%), Positives = 54/103 (52%), Gaps = 3/103 (2%)
Query: 143 NVVAFTKRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALH 202
N+ A+ + FNR+S+ EI K RA ++ FI VA++ + N +SL A+IS ++
Sbjct: 253 NLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEFFIDVARECFNIGNFNSLMAIISGMN 312
Query: 203 SASIYRLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLK 245
+ + RL KTWA K +FD L + N+ R L+
Sbjct: 313 MSPVSRLKKTWA---KVKTAKFDILEHQMDPSSNFYNYRTALR 352
>UniRef50_Q54L90 Cluster: RasGEF domain-containing protein; n=1;
Dictyostelium discoideum AX4|Rep: RasGEF
domain-containing protein - Dictyostelium discoideum AX4
Length = 1601
Score = 58.4 bits (135), Expect = 5e-07
Identities = 60/244 (24%), Positives = 105/244 (43%), Gaps = 19/244 (7%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQE 161
LS ++ Q TL+D F ++ + ++ T AP++ KR + W + E
Sbjct: 1020 LSAMEIAEQCTLVDYDLFTNVRLSDWVRLVQGSVDPQT-APSLSLALKRSTIWAQWAMGE 1078
Query: 162 ILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDK 221
IL+ + R I+ + VA +L N ++ ++ +AL + I RL +TW + K+
Sbjct: 1079 ILSTEDKSQRVAIINLLVDVAINCKDLANFNTAISIHTALTNHHIKRLQQTWDSVPKETL 1138
Query: 222 Q---QFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPA----GSP 274
Q ++ +++ + D +SI+ C+P I T L ID P GS
Sbjct: 1139 NKITQLEQSLQVWLKPDATNPFGVICQSINSACVPNFSILRTILSQIDQKIPTFSNDGSM 1198
Query: 275 HRVTKM----NIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLK 330
V K+ IV++ Q Y + P F+ ++++ D+ LSLK
Sbjct: 1199 VNVEKLRTIFGIVVEIQRLQQQRNYTMKP---TKLFIQ----LQDINTVSMDELADLSLK 1251
Query: 331 LEPP 334
EPP
Sbjct: 1252 CEPP 1255
>UniRef50_Q2URQ9 Cluster: Ras1 guanine nucleotide exchange factor;
n=2; Aspergillus|Rep: Ras1 guanine nucleotide exchange
factor - Aspergillus oryzae
Length = 1652
Score = 58.0 bits (134), Expect = 6e-07
Identities = 42/183 (22%), Positives = 79/183 (43%), Gaps = 12/183 (6%)
Query: 94 DIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVA----------PN 143
D V L + QLT++++ I ++L W+ + +V+
Sbjct: 1397 DHVPFILSCESQTLAQQLTIIEMAALSEIDWKDLVDMRWSSGSPSSVSWVQFLMEEERRG 1456
Query: 144 VVAFTKRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHS 203
+ RFN + W + EI+ ++ RA + FI A + N ++ + AL S
Sbjct: 1457 IDLVVGRFNLMVKWILSEIVLTRNIHERARTITKFIHTAAHARRMCNYATMLQIAIALSS 1516
Query: 204 ASIYRLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISLP--CIPYLGIFLTD 261
RL KTW + +D+ + L N+ LR +++ ++ CIP++G+++ D
Sbjct: 1517 TDCSRLQKTWGLVPSEDRGLLKDMEVLIQPVRNFHDLRVEMETANVQEGCIPFVGLYVHD 1576
Query: 262 LVY 264
L Y
Sbjct: 1577 LTY 1579
>UniRef50_A2QDU9 Cluster: Contig An02c0260, complete genome; n=4;
Trichocomaceae|Rep: Contig An02c0260, complete genome -
Aspergillus niger
Length = 1699
Score = 57.6 bits (133), Expect = 8e-07
Identities = 43/147 (29%), Positives = 67/147 (45%), Gaps = 8/147 (5%)
Query: 150 RFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRL 209
RFN + W + EI+ Q RA +A FI A + N ++ + AL S RL
Sbjct: 1510 RFNLMVRWVLSEIVLTQDIHERARTIAKFIHTAAHARRMCNYATMLQIAIALSSTDCSRL 1569
Query: 210 TKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISLP--CIPYLGIFLTDLVYIDI 267
TW + DK+ + L N+ LR ++ + CIP++G+++ DL Y
Sbjct: 1570 QATWDLVPVADKRLLKDMESLTQPIRNFHELRLEMEMANAQDGCIPFVGLYVHDLTY--- 1626
Query: 268 AHPAGSPHRVTKMN-IVLKALERYQSS 293
A P RVT + L ERY+++
Sbjct: 1627 --NAQKPARVTTQDGESLINFERYRTT 1651
>UniRef50_Q4SDT4 Cluster: Chromosome 1 SCAF14632, whole genome
shotgun sequence; n=2; Tetraodontidae|Rep: Chromosome 1
SCAF14632, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 504
Score = 56.0 bits (129), Expect = 3e-06
Identities = 25/71 (35%), Positives = 42/71 (59%)
Query: 143 NVVAFTKRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALH 202
N+ A+ + FNR+ + EI K RA+++ FI VA++ + N +SL A+IS ++
Sbjct: 269 NLEAYVRWFNRLCYLVATEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMAIISGMN 328
Query: 203 SASIYRLTKTW 213
+ + RL KTW
Sbjct: 329 MSPVSRLKKTW 339
>UniRef50_Q75BH9 Cluster: Guanine nucleotide exchange factor LTE1;
n=1; Eremothecium gossypii|Rep: Guanine nucleotide
exchange factor LTE1 - Ashbya gossypii (Yeast)
(Eremothecium gossypii)
Length = 1439
Score = 54.8 bits (126), Expect = 6e-06
Identities = 30/115 (26%), Positives = 54/115 (46%), Gaps = 2/115 (1%)
Query: 150 RFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRL 209
RFN W + E++ K R + I VA+ N +++ ++ AL+S + +
Sbjct: 1255 RFNLTVDWIISELVMTTDIKLRRNAIQRLIHVAEHCRMYQNYNTVMEIVLALNSVVVQKF 1314
Query: 210 TKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSIS--LPCIPYLGIFLTDL 262
T +W + D ++ L + N+ +R L SI CIP+L ++L+DL
Sbjct: 1315 TSSWRLIEPADMLTWEHLKSIPSLDRNYHNVRNLLNSIDPIKGCIPFLVVYLSDL 1369
>UniRef50_UPI000155BE40 Cluster: PREDICTED: similar to ras guanyl
releasing protein, partial; n=1; Ornithorhynchus
anatinus|Rep: PREDICTED: similar to ras guanyl releasing
protein, partial - Ornithorhynchus anatinus
Length = 340
Score = 54.0 bits (124), Expect = 1e-05
Identities = 44/166 (26%), Positives = 76/166 (45%), Gaps = 4/166 (2%)
Query: 171 RAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFDKLAEL 230
R + FI VA+ L++L N ++L AV+ L ++I RL +T A + + + +L EL
Sbjct: 160 RRVVFVKFIHVAQGLYKLQNFNTLMAVVGGLSHSAISRLKETSAHVPPEAGKTLGELTEL 219
Query: 231 FGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPA---GSPHRVTKMNIVLKAL 287
N+ + R S +P LG+ L DL+ + A P G V K+ + +
Sbjct: 220 LSSCRNYDSYRRAFGSCGAFRLPILGVHLKDLLALHEALPTYLDGGRVNVHKLLALHGHI 279
Query: 288 ERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEP 333
+ PL + ++ + +L + ED+ Y+LS EP
Sbjct: 280 SDLVRLQDTAPPLEANKDLVHLLTLSLDLY-YTEDEIYELSYAREP 324
>UniRef50_Q9TVI2 Cluster: Putative uncharacterized protein plc-1;
n=4; Caenorhabditis|Rep: Putative uncharacterized
protein plc-1 - Caenorhabditis elegans
Length = 1898
Score = 53.6 bits (123), Expect = 1e-05
Identities = 42/172 (24%), Positives = 75/172 (43%), Gaps = 13/172 (7%)
Query: 104 PDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPN---VVAFTKRFNRVSFWTVQ 160
P++V QL+ + F +I+P + L + V+ N V KR + VS W
Sbjct: 67 PEEVAFQLSSTEYQLFYSIQPMDYVRYVSCDLTSVPVSENPSPVRNLVKRLSEVSSWITH 126
Query: 161 EILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKD 220
I++ + R + +++ + + N ++ V+ L S +L W L +++
Sbjct: 127 VIVSQPTHDDRKVALTAILRIVETCWNIGNFNAAVEVLMGLKSE---KLRPFWLSLRQEE 183
Query: 221 KQQFDKLAELFGETDNWTALREYLKSIS----LP---CIPYLGIFLTDLVYI 265
K QFD L E + + Y+ ++ +P IP+ GIFL DL I
Sbjct: 184 KSQFDSLCETLLPANQALPSQAYINAVQRALRMPQSRVIPFFGIFLRDLYAI 235
>UniRef50_P25300 Cluster: Bud site selection protein 5; n=4;
Saccharomyces cerevisiae|Rep: Bud site selection protein
5 - Saccharomyces cerevisiae (Baker's yeast)
Length = 642
Score = 53.6 bits (123), Expect = 1e-05
Identities = 61/252 (24%), Positives = 114/252 (45%), Gaps = 27/252 (10%)
Query: 94 DIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNR 153
++ AL +SP + LTLL+ + I+ E T K N T+ FT N+
Sbjct: 403 EVEAFALNVSPWSLAKTLTLLESSLYLDIETIEFTR--HFKHNDTTIDS---VFTLS-NQ 456
Query: 154 VSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTW 213
+S + ++ L + ++++++VA L NL+SL ++I++L + SI RL+
Sbjct: 457 LSSYVLETTLQ------QTHTISYWLQVALSCLYLRNLNSLASIITSLQNHSIERLSLP- 509
Query: 214 ACLSKKDKQQFDKLAELFGETDNWTALREYLKSI---SLPCIPYLGIFLTDLVYI----D 266
+ K F +L + +N+ R +K I LPC+P+ + + D+ +I D
Sbjct: 510 --IDVKSDHLFQRLKVVVHPNNNYNVYRRTIKHIFHSQLPCVPFTSLLIRDITFIRDGND 567
Query: 267 IAHPAGSPHRVTKMNIVLK--ALERY-QSSEYEIAPLPHVA--NFLNSVRYIEELQKFVE 321
G+ + K N + K A +Y Q +YE + + L ++ + L +
Sbjct: 568 TFTKDGNNVNMQKFNQITKIVAFAQYLQQKQYEDIHCSNTTARSLLGAMIKVHTLYNDNK 627
Query: 322 DDQYKLSLKLEP 333
D Y++S+ P
Sbjct: 628 DRAYQVSIAKVP 639
>UniRef50_Q21758 Cluster: Putative uncharacterized protein; n=2;
Caenorhabditis|Rep: Putative uncharacterized protein -
Caenorhabditis elegans
Length = 461
Score = 53.2 bits (122), Expect = 2e-05
Identities = 38/167 (22%), Positives = 74/167 (44%), Gaps = 14/167 (8%)
Query: 120 KAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNGQSPKARAEIMAHFI 179
+++ + L+ G NK ++ + + FNR+S + E+L + R + I
Sbjct: 223 QSLASDPLSEIGRHSKNKEGTISSISFYIEWFNRLSAFAAIEVLKQTKKRNRVAVFEFMI 282
Query: 180 KVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFDKLAELFGETDNWTA 239
+AK+ E+ N +S+ A+++ L ++ RL KTW + +K + + L + N+ +
Sbjct: 283 DIAKECCEIGNFNSMMAIVAGLSLPAVSRLKKTWC---RVEKAKLEILQHQLDPSGNFLS 339
Query: 240 LREYLKSISLPC-----------IPYLGIFLTDLVYIDIAHPAGSPH 275
R +K+ IP+ + L DL I HP P+
Sbjct: 340 YRATIKAAQWRADSARGNQQKIVIPFFVLLLKDLFLIYHGHPRILPN 386
>UniRef50_Q4S7S0 Cluster: Chromosome 18 SCAF14712, whole genome
shotgun sequence; n=2; Tetraodontidae|Rep: Chromosome 18
SCAF14712, whole genome shotgun sequence - Tetraodon
nigroviridis (Green puffer)
Length = 782
Score = 52.4 bits (120), Expect = 3e-05
Identities = 23/51 (45%), Positives = 35/51 (68%), Gaps = 1/51 (1%)
Query: 187 ELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFDKLAELFGETDNW 237
+L N SL A++SAL S ++YRL KTWA +S++ FD+L + F + +NW
Sbjct: 298 QLKNFSSLRAILSALQSNAVYRLKKTWAAVSRESMATFDQLCQTFPD-ENW 347
>UniRef50_A2DTE7 Cluster: RasGEF domain containing protein; n=1;
Trichomonas vaginalis G3|Rep: RasGEF domain containing
protein - Trichomonas vaginalis G3
Length = 756
Score = 52.4 bits (120), Expect = 3e-05
Identities = 42/155 (27%), Positives = 71/155 (45%), Gaps = 8/155 (5%)
Query: 104 PDDVGNQLTLLDLPCFKAIKPEEL-TTCGWTKLNKLTVAPN-VVAFTKRFNRVSFWTVQE 161
P++ Q+ LL F +I P E T T N + AF K+ + T+
Sbjct: 431 PEETARQICLLTQQIFSSINPREFYTAIANRSYGPTTPGLNELYAFGKQLKHRAMRTI-- 488
Query: 162 ILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDK 221
+ G + +A+ + M I++A+KL ELNN S+ ++ A S I L+ + LS++ +
Sbjct: 489 VGEGDASEAK-DNMEIVIQIAQKLEELNNYESITWIVDAFDSDIIANLSGIFDSLSEESR 547
Query: 222 QQFDKLAELFGETDNWTALREYL---KSISLPCIP 253
L E +G T+ A E + + PC+P
Sbjct: 548 NMITDLKERYGFTEKSDAYEENVLKCQKEGKPCVP 582
>UniRef50_Q4P4A0 Cluster: Putative uncharacterized protein; n=1;
Ustilago maydis|Rep: Putative uncharacterized protein -
Ustilago maydis (Smut fungus)
Length = 1762
Score = 52.4 bits (120), Expect = 3e-05
Identities = 30/115 (26%), Positives = 56/115 (48%)
Query: 134 KLNKLTVAPNVVAFTKRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHS 193
+L +L V A RFN S W E++ Q+ RA +++ I++A K + +N S
Sbjct: 1493 RLGELHQEHAVEAIVARFNLTSNWVASEVVLTQNIDERAAVISKLIRIAWKCYLQSNFAS 1552
Query: 194 LFAVISALHSASIYRLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSIS 248
L +I L++ + RL +TW+ + + + + L G N+ LR + ++
Sbjct: 1553 LAQIIFGLNTPWVQRLRRTWSRVGYFETRMWRDLNSFVGPRHNFRHLRNAMLKVA 1607
>UniRef50_UPI0000499745 Cluster: hypothetical protein 71.t00010;
n=1; Entamoeba histolytica HM-1:IMSS|Rep: hypothetical
protein 71.t00010 - Entamoeba histolytica HM-1:IMSS
Length = 656
Score = 51.2 bits (117), Expect = 7e-05
Identities = 34/125 (27%), Positives = 64/125 (51%), Gaps = 8/125 (6%)
Query: 179 IKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFDKLAELFGETDNWT 238
IK+AK+ E ++ + + V S L S S + ++ W + KK Q F+KL E++ + N+
Sbjct: 516 IKIAKECFEESDFNMSYLVFSCL-STSFSQCSELWNKIEKKHIQTFEKLQEIYSISRNFN 574
Query: 239 ALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPH-------RVTKMNIVLKALERYQ 291
R ++ + P IP L +++ D+V I+ P ++ ++ +LK L Q
Sbjct: 575 NYRISFENKAFPKIPILSLWMHDIVNINEQDTFTDPQKRYLNLAKMRSLSSILKLLHYSQ 634
Query: 292 SSEYE 296
+ +YE
Sbjct: 635 TIKYE 639
>UniRef50_Q8N9B8 Cluster: Ras-GEF domain-containing family member
1A; n=21; Amniota|Rep: Ras-GEF domain-containing family
member 1A - Homo sapiens (Human)
Length = 481
Score = 51.2 bits (117), Expect = 7e-05
Identities = 40/147 (27%), Positives = 67/147 (45%), Gaps = 11/147 (7%)
Query: 107 VGNQLTLLDLPCFKAIKPEELT--TCGWTKLNK------LTVAPNVVAFTKRFNRVSFWT 158
+ QLT ++L +I PE+L L+ LT ++ A+ FN +S
Sbjct: 218 LAQQLTHIELDRVSSIYPEDLMQIVSHMDSLDNHRCRGDLTKTYSLEAYDNWFNCLSMLV 277
Query: 159 VQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSK 218
E+ K R ++ FI VA++ + N +S+ A+IS ++ + + RL KTW SK
Sbjct: 278 ATEVCRVVKKKHRTRMLEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLKKTW---SK 334
Query: 219 KDKQQFDKLAELFGETDNWTALREYLK 245
+FD L + N+ R L+
Sbjct: 335 VKTAKFDVLEHHMDPSSNFCNYRTALQ 361
>UniRef50_Q9P212 Cluster: 1-phosphatidylinositol-4,5-bisphosphate
phosphodiesterase epsilon-1; n=28; Amniota|Rep:
1-phosphatidylinositol-4,5-bisphosphate
phosphodiesterase epsilon-1 - Homo sapiens (Human)
Length = 2302
Score = 50.8 bits (116), Expect = 1e-04
Identities = 38/161 (23%), Positives = 75/161 (46%), Gaps = 13/161 (8%)
Query: 106 DVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNG 165
D+G LPC KA + T T+ + ++V RFN VS W IL
Sbjct: 562 DLGTPECQSSLPCLKASISASILT---TQNGEHNALEDLVM---RFNEVSSWVTWLILTA 615
Query: 166 QSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFD 225
S + + E+ ++ + VAK + N +++ ++ L S ++ K W + + D +
Sbjct: 616 GSMEEKREVFSYLVHVAKCCWNMGNYNAVMEFLAGLRSR---KVLKMWQFMDQSDIETMR 672
Query: 226 KLAELFGETDNWTALREYL-KSISLP-C--IPYLGIFLTDL 262
L + + ++ R+ + +++ +P C +P+ G+FL +L
Sbjct: 673 SLKDAMAQHESSCEYRKVVTRALHIPGCKVVPFCGVFLKEL 713
>UniRef50_Q76NI1 Cluster: Kinase non-catalytic C-lobe
domain-containing protein 1; n=22; Euarchontoglires|Rep:
Kinase non-catalytic C-lobe domain-containing protein 1 -
Homo sapiens (Human)
Length = 1684
Score = 50.4 bits (115), Expect = 1e-04
Identities = 36/161 (22%), Positives = 74/161 (45%), Gaps = 9/161 (5%)
Query: 154 VSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTW 213
VS W EI+ + K + +++ F+ +AK +E N + ++S L ++ R + W
Sbjct: 1479 VSTWVAAEIVTSHTSKLQVNLLSKFLLIAKSCYEQRNFATAMQILSGLEHLAV-RQSPAW 1537
Query: 214 ACLSKKDKQQFDKL--AELFGETDNWTAL--REYLKSISLPCIPYLGIFLTDLVYIDIAH 269
L K + ++L E+F +D+ + R + +LP L + + L
Sbjct: 1538 RILPAKIAEVMEELKAVEVFLRSDSLCLMEGRRFRAQPTLPSAHLLAMHIQQLETGGFTM 1597
Query: 270 PAGSPHRVTKMNIVLKALER---YQSSEYEIAPLPHVANFL 307
G+ HR +K+ + K + + +Q + Y +P P + ++L
Sbjct: 1598 TNGA-HRWSKLRNIAKVVSQVHAFQENPYTFSPDPKLQSYL 1637
>UniRef50_UPI00015617B8 Cluster: PREDICTED: similar to ral guanine
nucleotide dissociation stimulator, partial; n=1; Equus
caballus|Rep: PREDICTED: similar to ral guanine
nucleotide dissociation stimulator, partial - Equus
caballus
Length = 557
Score = 49.2 bits (112), Expect = 3e-04
Identities = 38/132 (28%), Positives = 60/132 (45%), Gaps = 5/132 (3%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLT---VAPNVVAFTKRFNRVSF 156
L P V QLT + FK + P W++ + +AP V N V+
Sbjct: 167 LDFPPQLVAEQLTRMAAELFKTLVPAHCLGSIWSERDNREREYLAPTVRDSVMHDNTVAN 226
Query: 157 WTVQEILNGQSPKA--RAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWA 214
+ L S A RA ++ +I+VA++ L N SL ++SAL S +I RL TW
Sbjct: 227 CILVTCLGDPSMTAQDRARVVELWIRVAEECRGLGNFCSLHTILSALQSPAIARLQDTWG 286
Query: 215 CLSKKDKQQFDK 226
+S++ + + K
Sbjct: 287 QVSRESSRTWKK 298
>UniRef50_UPI00015616C9 Cluster: PREDICTED: similar to ral guanine
nucleotide dissociation stimulator; n=16; Equus
caballus|Rep: PREDICTED: similar to ral guanine
nucleotide dissociation stimulator - Equus caballus
Length = 698
Score = 49.2 bits (112), Expect = 3e-04
Identities = 40/151 (26%), Positives = 67/151 (44%), Gaps = 5/151 (3%)
Query: 81 SLPAACSINQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLN---K 137
S P A + + + L P V QLT + FK + P W++ + +
Sbjct: 224 SCPWAVTTEDQLREEKLNILDFPPQLVAEQLTRMAAELFKTLVPTHCLGSIWSERDNRER 283
Query: 138 LTVAPNVVAFTKRFNRVSFWTVQEILNGQSPKA--RAEIMAHFIKVAKKLHELNNLHSLF 195
++AP V N V+ + L S A RA ++ +I+VA++ L N SL
Sbjct: 284 ESLAPTVGDTVMHDNTVANCILVTCLGDASMTAQDRARVVELWIRVAEECRGLGNFCSLH 343
Query: 196 AVISALHSASIYRLTKTWACLSKKDKQQFDK 226
++SAL S +I L TW +S++ + + K
Sbjct: 344 TILSALQSPAIAHLQDTWGQVSRESSRTWKK 374
>UniRef50_UPI000155FBAC Cluster: PREDICTED: similar to ral guanine
nucleotide dissociation stimulator, partial; n=1; Equus
caballus|Rep: PREDICTED: similar to ral guanine
nucleotide dissociation stimulator, partial - Equus
caballus
Length = 514
Score = 48.8 bits (111), Expect = 4e-04
Identities = 38/132 (28%), Positives = 60/132 (45%), Gaps = 5/132 (3%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLN---KLTVAPNVVAFTKRFNRVSF 156
L P V QLT + FK + P W++ + + ++AP V N V+
Sbjct: 264 LDFPPQLVAEQLTRMAAELFKTLVPAHCLGSIWSERDNRERESLAPTVRDTAMHDNTVAN 323
Query: 157 WTVQEILNGQSPKA--RAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWA 214
+ L S A RA ++ +I VA + L N SL ++SAL S +I RL TW
Sbjct: 324 CILVTCLGDASMTAQDRARVVELWISVADECRGLGNFCSLHTILSALQSPAIARLQDTWG 383
Query: 215 CLSKKDKQQFDK 226
+S++ + + K
Sbjct: 384 QVSRESSRTWKK 395
>UniRef50_UPI000065E6FA Cluster:
1-phosphatidylinositol-4,5-bisphosphate
phosphodiesterase epsilon 1 (EC 3.1.4.11) (Phospholipase
C-epsilon-1) (PLC-epsilon-1) (Phosphoinositide-specific
phospholipase C epsilon-1) (Pancreas- enriched
phospholipase C).; n=9; Euteleostomi|Rep:
1-phosphatidylinositol-4,5-bisphosphate
phosphodiesterase epsilon 1 (EC 3.1.4.11) (Phospholipase
C-epsilon-1) (PLC-epsilon-1) (Phosphoinositide-specific
phospholipase C epsilon-1) (Pancreas- enriched
phospholipase C). - Takifugu rubripes
Length = 1761
Score = 48.4 bits (110), Expect = 5e-04
Identities = 27/117 (23%), Positives = 60/117 (51%), Gaps = 7/117 (5%)
Query: 150 RFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRL 209
RFN VS W IL S + + E+ ++ + VAK + N + + ++ L S ++
Sbjct: 150 RFNEVSSWVTWLILTAGSMEEKREVFSYLVNVAKCCWNMGNYNGVMEFLAGLRSR---KV 206
Query: 210 TKTWACLSKKDKQQFDKLAELFGETDNWTALREYL-KSISLP-C--IPYLGIFLTDL 262
K W + + D + L + + ++ + ++ + +++++P C +P+ G+FL +L
Sbjct: 207 LKMWQFMDQTDIETMRSLKDAMAQHESSSEYKKVVTRALNIPGCKVVPFCGVFLKEL 263
>UniRef50_UPI00015A537C Cluster: UPI00015A537C related cluster; n=1;
Danio rerio|Rep: UPI00015A537C UniRef100 entry - Danio
rerio
Length = 383
Score = 47.2 bits (107), Expect = 0.001
Identities = 33/157 (21%), Positives = 71/157 (45%), Gaps = 5/157 (3%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTV 159
+ L P ++ QLTLL+ + I+P EL WTK +K +PN++ + ++ W
Sbjct: 84 MTLHPIEIARQLTLLESDFYSVIQPSELVGSVWTKEDKEINSPNLLRMIRHTTNLTLWLE 143
Query: 160 QEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKK 219
+ I+ ++ + E + I L N + + + + + + + + +
Sbjct: 144 KCIVETENVE---EQIGFLILSYSYLFNANTNVTRPSEMMQICNVCVCVCVCVFQQIPSR 200
Query: 220 DKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLG 256
++ ++ EL D++ L+SI+ PC+P+ G
Sbjct: 201 QRKILEEAHEL--SEDHYKKYLAKLRSINPPCVPFFG 235
>UniRef50_A2ELJ3 Cluster: RasGEF domain containing protein; n=1;
Trichomonas vaginalis G3|Rep: RasGEF domain containing
protein - Trichomonas vaginalis G3
Length = 510
Score = 47.2 bits (107), Expect = 0.001
Identities = 39/180 (21%), Positives = 78/180 (43%), Gaps = 17/180 (9%)
Query: 106 DVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNG 165
++ QL + F+ I+ ++ W K + FN S + + I+N
Sbjct: 268 ELARQLNYFFMMQFRQIQSTDILATAWGS-KKEHNSEKFELMINYFNDFSCFVSRSIINA 326
Query: 166 Q-SPKARAEIMAHFIKVA-----------KKLHELNNLHSLFAVISALHSASIYRLTKTW 213
P RA ++ ++ +A ++ N H++FA++ + SI RLT+T
Sbjct: 327 SPDPHERARVIKRWVDIAYICLNPEQQDSAPYNKFVNYHAVFAIMYGVTHPSINRLTETQ 386
Query: 214 ACLSKKDK---QQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHP 270
++ +K ++ EL + N+ +E L + + C+P++G+ +LVYI P
Sbjct: 387 KFATRTNKVRNAHIQEMNELINQVGNFKVYKEKLAN-TARCLPFVGVLQKELVYITEMFP 445
>UniRef50_UPI00015B5A66 Cluster: PREDICTED: similar to phospholipase
c epsilon; n=1; Nasonia vitripennis|Rep: PREDICTED:
similar to phospholipase c epsilon - Nasonia vitripennis
Length = 1801
Score = 46.8 bits (106), Expect = 0.002
Identities = 36/162 (22%), Positives = 70/162 (43%), Gaps = 7/162 (4%)
Query: 104 PDDVGNQLTLLDLPCFKAIKPEEL---TTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQ 160
P++V +L + F + P E + +T + +V RFN V+ W
Sbjct: 66 PEEVALRLAESEYQLFYQVPPGEYLRHVSQDFTASQQRQQQQHVQTLIDRFNEVNSWVSH 125
Query: 161 EILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKD 220
I +G + + R +++ ++VA+ + N +S +++ L S +L W +S++
Sbjct: 126 VISSGSTVEERQALLSCLLRVAQTCWNIGNFNSAMEIVAGLKSN---KLKPFWQTVSEQI 182
Query: 221 KQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDL 262
D L+ ++ AL L P +P+ G FL +L
Sbjct: 183 PV-LDYLSSALLSSEYEHALARALSMPECPVVPFFGAFLREL 223
>UniRef50_UPI0001561431 Cluster: PREDICTED: similar to pleckstrin
homology domain containing, family B (evectins) member
2; n=3; Equus caballus|Rep: PREDICTED: similar to
pleckstrin homology domain containing, family B
(evectins) member 2 - Equus caballus
Length = 593
Score = 46.4 bits (105), Expect = 0.002
Identities = 58/245 (23%), Positives = 105/245 (42%), Gaps = 26/245 (10%)
Query: 104 PDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTV---APNVVAFTKRFNRVSFWTVQ 160
P V QLT + FK + P W++ + + AP V N ++ +
Sbjct: 352 PQLVAEQLTRMAAELFKTLVPAHCLGSIWSECDNRELEYLAPTVRDTVMHDNTMANCILV 411
Query: 161 EILNGQSPKA--RAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSK 218
L S A RA ++ ++ VA++ +L N SL ++SAL S +I L +TW +S+
Sbjct: 412 TCLGDLSMTAQDRARVVELWVWVAEECRDLGNFSSLHTILSALQSPAITHLQETWGQVSR 471
Query: 219 KDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPHRVT 278
F + + + R+ ++ + L + D Y++++ P
Sbjct: 472 ----DFQEATSMLVTAER---ARQGVQERQGHSLELLDAMMQD--YVEMSEPGRDVLNCQ 522
Query: 279 KMNI---VLKALERYQSSEYEIAPLPHVANFLNSVR-------YIEELQKFVEDDQYKLS 328
K N V K ++++ E EI L AN L +V+ + + ++ E++ Y LS
Sbjct: 523 KWNEGGRVPKRAKQFKLME-EIELLQEAAN-LYTVQPDKHFGAWFQAMEPLSEEESYSLS 580
Query: 329 LKLEP 333
+LEP
Sbjct: 581 CQLEP 585
>UniRef50_UPI000156180A Cluster: PREDICTED: similar to Ral guanine
nucleotide dissociation stimulator; n=7; Equus
caballus|Rep: PREDICTED: similar to Ral guanine
nucleotide dissociation stimulator - Equus caballus
Length = 738
Score = 46.0 bits (104), Expect = 0.003
Identities = 32/132 (24%), Positives = 59/132 (44%), Gaps = 5/132 (3%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLT---VAPNVVAFTKRFNRVSF 156
L P V +QL ++ FK + P + W++ + +AP + N ++
Sbjct: 446 LDFPPKLVADQLARMEAELFKKLVPAQCLGPIWSQRDNRDHEYLAPTIRDTVAHMNTLAN 505
Query: 157 WTVQEILN--GQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWA 214
+ G + + RA ++ +I+VA+ L N S ++SAL S +I L +TW
Sbjct: 506 SAIATCFGAPGMTAQERARVVELWIQVAEGCRGLRNFSSFHRILSALQSPAIKHLKETWG 565
Query: 215 CLSKKDKQQFDK 226
+S++ F K
Sbjct: 566 QVSRESSYTFKK 577
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.132 0.407
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 673,242,912
Number of Sequences: 1657284
Number of extensions: 28773096
Number of successful extensions: 64836
Number of sequences better than 10.0: 291
Number of HSP's better than 10.0 without gapping: 252
Number of HSP's successfully gapped in prelim test: 39
Number of HSP's that attempted gapping in prelim test: 64217
Number of HSP's gapped (non-prelim): 392
length of query: 576
length of database: 575,637,011
effective HSP length: 105
effective length of query: 471
effective length of database: 401,622,191
effective search space: 189164051961
effective search space used: 189164051961
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
S2: 75 (34.3 bits)
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