Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA000696-TA|BGIBMGA000696-PA|IPR001849|Pleckstrin-like,
IPR001895|Guanine-nucleotide dissociation stimulator CDC25,
IPR008937|Ras guanine nucleotide exchange factor
(576 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
AL450263-6|CAI41461.1| 557|Homo sapiens Ral GEF with PH domain ... 393 e-109
AL357623-3|CAH72701.1| 557|Homo sapiens Ral GEF with PH domain ... 393 e-109
AL356862-3|CAI39720.1| 557|Homo sapiens Ral GEF with PH domain ... 393 e-109
AL160169-3|CAI40640.1| 557|Homo sapiens Ral GEF with PH domain ... 393 e-109
AB002349-1|BAA20808.2| 590|Homo sapiens KIAA0351 protein. 393 e-109
AL450263-5|CAI41460.1| 529|Homo sapiens Ral GEF with PH domain ... 374 e-103
AL357623-2|CAH72700.1| 529|Homo sapiens Ral GEF with PH domain ... 374 e-103
AL356862-2|CAI39719.1| 529|Homo sapiens Ral GEF with PH domain ... 374 e-103
AL160169-2|CAI40639.1| 529|Homo sapiens Ral GEF with PH domain ... 374 e-103
AF221098-1|AAF65253.1| 529|Homo sapiens Ral guanine nucleotide ... 374 e-103
BC047391-1|AAH47391.1| 583|Homo sapiens Ral GEF with PH domain ... 325 3e-88
AL355520-3|CAI21920.1| 583|Homo sapiens Ral GEF with PH domain ... 325 3e-88
AL162255-3|CAH71097.1| 583|Homo sapiens Ral GEF with PH domain ... 325 3e-88
AL355520-2|CAI21919.1| 548|Homo sapiens Ral GEF with PH domain ... 311 4e-84
AL162255-4|CAH71098.1| 548|Homo sapiens Ral GEF with PH domain ... 311 4e-84
BC032372-1|AAH32372.1| 305|Homo sapiens RALGPS1 protein protein. 300 7e-81
BC033708-1|AAH33708.1| 384|Homo sapiens RALGPS1 protein protein. 299 2e-80
AL357623-4|CAH72702.1| 384|Homo sapiens Ral GEF with PH domain ... 299 2e-80
AL357623-1|CAH72699.1| 305|Homo sapiens Ral GEF with PH domain ... 299 2e-80
AL356862-4|CAI39721.1| 384|Homo sapiens Ral GEF with PH domain ... 299 2e-80
AL356862-1|CAI39718.1| 305|Homo sapiens Ral GEF with PH domain ... 299 2e-80
AL160169-4|CAI40641.1| 384|Homo sapiens Ral GEF with PH domain ... 299 2e-80
AL160169-1|CAI40638.1| 305|Homo sapiens Ral GEF with PH domain ... 299 2e-80
AL355520-1|CAI21918.1| 279|Homo sapiens Ral GEF with PH domain ... 287 5e-77
AL162255-2|CAH71096.1| 279|Homo sapiens Ral GEF with PH domain ... 287 5e-77
AK001106-1|BAA91506.1| 279|Homo sapiens protein ( Homo sapiens ... 287 5e-77
AL356862-6|CAI39723.1| 213|Homo sapiens Ral GEF with PH domain ... 219 3e-56
AL160169-6|CAI40643.1| 213|Homo sapiens Ral GEF with PH domain ... 219 3e-56
BC126112-1|AAI26113.1| 1237|Homo sapiens Ras protein-specific gu... 133 1e-30
AF181250-1|AAD55268.1| 1237|Homo sapiens Ras guanine nucleotide ... 133 1e-30
AF023130-1|AAB80953.1| 1237|Homo sapiens Ras-GRF2 protein. 133 1e-30
S62035-1|AAB26881.1| 489|Homo sapiens Ras-specific guanine nucl... 129 2e-29
L26584-1|AAA58417.1| 1275|Homo sapiens CDC25 protein. 129 2e-29
AL356862-5|CAI39722.1| 173|Homo sapiens Ral GEF with PH domain ... 129 2e-29
AL160169-5|CAI40642.1| 173|Homo sapiens Ral GEF with PH domain ... 129 2e-29
AL450263-1|CAI41454.1| 152|Homo sapiens Ral GEF with PH domain ... 118 7e-26
D21239-1|BAA04770.1| 1077|Homo sapiens C3G protein protein. 111 5e-24
BC041710-1|AAH41710.1| 1095|Homo sapiens Rap guanine nucleotide ... 111 5e-24
AL160276-7|CAI40651.1| 1023|Homo sapiens Rap guanine nucleotide ... 111 5e-24
AL160276-3|CAI40647.1| 1094|Homo sapiens Rap guanine nucleotide ... 111 5e-24
AL160276-2|CAI40646.1| 1077|Homo sapiens Rap guanine nucleotide ... 111 5e-24
AL160271-3|CAI13383.1| 1094|Homo sapiens Rap guanine nucleotide ... 111 5e-24
AL160271-2|CAI13382.1| 1077|Homo sapiens Rap guanine nucleotide ... 111 5e-24
L13857-1|AAA35913.1| 1333|Homo sapiens guanine nucleotide exchan... 108 5e-23
AF441482-1|AAM22406.1| 1105|Homo sapiens alternate SOS1 protein. 108 5e-23
AC019171-1|AAX93186.1| 1304|Homo sapiens unknown protein. 108 5e-23
AB209140-1|BAD92377.1| 988|Homo sapiens son of sevenless homolo... 108 5e-23
AL355520-9|CAI21925.1| 150|Homo sapiens Ral GEF with PH domain ... 107 1e-22
AK098470-1|BAC05311.1| 232|Homo sapiens protein ( Homo sapiens ... 107 1e-22
L20686-1|AAA91852.1| 572|Homo sapiens guanine nucleotide releas... 106 2e-22
L13858-1|AAA35914.1| 1332|Homo sapiens guanine nucleotide exchan... 106 2e-22
BC117261-1|AAI17262.1| 1332|Homo sapiens son of sevenless homolo... 106 2e-22
AB209277-1|BAD92514.1| 1231|Homo sapiens son of sevenless homolo... 106 2e-22
BC059362-1|AAH59362.1| 902|Homo sapiens RALGDS protein protein. 105 6e-22
AL162417-12|CAI13417.1| 859|Homo sapiens ral guanine nucleotide... 105 6e-22
AL162417-11|CAI13415.1| 914|Homo sapiens ral guanine nucleotide... 105 6e-22
AL162417-10|CAI13416.1| 902|Homo sapiens ral guanine nucleotide... 105 6e-22
AK127524-1|BAC87018.1| 913|Homo sapiens protein ( Homo sapiens ... 105 6e-22
AK090450-1|BAC03431.1| 625|Homo sapiens FLJ00371 protein protein. 105 6e-22
AK074114-1|BAB84940.1| 824|Homo sapiens FLJ00185 protein protein. 105 6e-22
AF295773-1|AAG02122.1| 914|Homo sapiens ral guanine nucleotide ... 105 6e-22
AF027169-1|AAQ13414.1| 859|Homo sapiens Ral guanine nucleotide ... 105 6e-22
AB037729-1|BAA92546.1| 745|Homo sapiens KIAA1308 protein protein. 105 6e-22
AL355520-6|CAI21922.1| 223|Homo sapiens Ral GEF with PH domain ... 101 9e-21
BC111958-1|AAI11959.1| 710|Homo sapiens ral guanine nucleotide ... 100 2e-20
BC101756-1|AAI01757.1| 710|Homo sapiens ral guanine nucleotide ... 100 2e-20
AK074082-1|BAB84908.1| 497|Homo sapiens FLJ00153 protein protein. 100 2e-20
BC117321-1|AAI17322.1| 1486|Homo sapiens RAPGEF2 protein protein. 97 2e-19
AC074344-1|AAY40909.1| 1479|Homo sapiens unknown protein. 97 2e-19
AB002311-1|BAA20772.2| 1508|Homo sapiens KIAA0313 protein. 97 2e-19
BC133703-1|AAI33704.1| 1504|Homo sapiens RAPGEF6 protein protein. 95 6e-19
AK074318-1|BAB85049.1| 1113|Homo sapiens protein ( Homo sapiens ... 95 6e-19
AF478567-1|AAM21637.1| 1601|Homo sapiens PDZ domain-containing g... 95 6e-19
AF478469-1|AAL79916.1| 1391|Homo sapiens Rap1 guanine nucleotide... 95 6e-19
AF478468-1|AAL79915.1| 1601|Homo sapiens Rap1 guanine nucleotide... 95 6e-19
AF394782-1|AAK83368.1| 1509|Homo sapiens rap guanine nucleotide ... 95 6e-19
AF117947-1|AAF22004.1| 1204|Homo sapiens PDZ domain-containing g... 95 6e-19
BC027849-1|AAH27849.1| 690|Homo sapiens RAS guanyl releasing pr... 94 1e-18
AC020594-2|AAY15037.1| 690|Homo sapiens unknown protein. 94 1e-18
AB020653-1|BAA74869.2| 691|Homo sapiens KIAA0846 protein protein. 94 1e-18
AL355520-8|CAI21924.1| 145|Homo sapiens Ral GEF with PH domain ... 92 4e-18
BX537416-1|CAD97658.1| 803|Homo sapiens hypothetical protein pr... 91 7e-18
AL592299-5|CAI14724.1| 768|Homo sapiens ral guanine nucleotide ... 91 7e-18
AL592299-1|CAI14720.1| 803|Homo sapiens ral guanine nucleotide ... 91 7e-18
AL590422-2|CAH73874.1| 768|Homo sapiens ral guanine nucleotide ... 91 7e-18
AL590422-1|CAH73873.1| 803|Homo sapiens ral guanine nucleotide ... 91 7e-18
AL080117-1|CAB45716.1| 754|Homo sapiens hypothetical protein pr... 91 7e-18
AF186798-2|AAG14401.1| 803|Homo sapiens RalGDS-like protein. 91 7e-18
AF186798-1|AAG14400.1| 768|Homo sapiens RalGDS-like protein. 91 7e-18
AF186780-1|AAF67281.1| 803|Homo sapiens RGL protein protein. 91 7e-18
AF186779-1|AAF67280.1| 768|Homo sapiens RGL protein protein. 91 7e-18
AB023176-1|BAA76803.1| 820|Homo sapiens KIAA0959 protein protein. 91 7e-18
BC092404-1|AAH92404.1| 881|Homo sapiens Rap guanine nucleotide ... 91 1e-17
BC017728-1|AAH17728.1| 881|Homo sapiens Rap guanine nucleotide ... 91 1e-17
AF103905-1|AAC83381.1| 881|Homo sapiens Rap1 guanine-nucleotide... 91 1e-17
BC040183-1|AAH40183.1| 867|Homo sapiens RAPGEF4 protein protein. 89 4e-17
BC024004-1|AAH24004.1| 1011|Homo sapiens Rap guanine nucleotide ... 89 4e-17
AB209681-1|BAD92918.1| 643|Homo sapiens RAP guanine-nucleotide-... 89 4e-17
AB075513-1|BAE45759.1| 478|Homo sapiens putative protein produc... 89 4e-17
AB027471-1|BAB72179.1| 1011|Homo sapiens cAMP-GEFII protein. 89 4e-17
U78516-1|AAD03422.1| 1011|Homo sapiens cAMP-regulated guanine nu... 89 5e-17
U78168-1|AAD12740.1| 881|Homo sapiens cAMP-regulated guanine nu... 89 5e-17
AY101396-1|AAM51551.1| 473|Homo sapiens Ral-GDS related protein... 88 9e-17
BC115375-1|AAI15376.1| 456|Homo sapiens Rap guanine nucleotide ... 85 5e-16
BC115374-1|AAI15375.1| 456|Homo sapiens Rap guanine nucleotide ... 85 5e-16
AF448437-1|AAL87858.1| 673|Homo sapiens guanyl nucleotide relea... 85 5e-16
AF117946-1|AAF22003.1| 456|Homo sapiens Link guanine nucleotide... 85 5e-16
D87467-1|BAA13406.2| 583|Homo sapiens KIAA0277 protein. 85 6e-16
AY048121-1|AAK85703.1| 659|Homo sapiens RAS guanyl releasing pr... 85 6e-16
AY048119-1|AAK85701.1| 673|Homo sapiens RAS guanyl releasing pr... 85 6e-16
Y12336-1|CAA73005.1| 609|Homo sapiens F25B3.3 kinase like prote... 82 6e-15
U78170-1|AAD12741.1| 609|Homo sapiens calcium- and diacylglycer... 82 6e-15
BC117151-1|AAI17152.1| 609|Homo sapiens RAS guanyl releasing pr... 82 6e-15
BC110306-1|AAI10307.1| 662|Homo sapiens RASGRP2 protein protein. 82 6e-15
AF081194-1|AAC79698.1| 609|Homo sapiens calcium and DAG-regulat... 82 6e-15
AF043723-1|AAF07220.1| 609|Homo sapiens guanine exchange factor... 82 6e-15
AF043722-1|AAF07219.1| 671|Homo sapiens guanine exchange factor... 82 6e-15
Z97184-2|CAB09992.1| 777|Homo sapiens RAB2, member RAS oncogene... 76 3e-13
BX000343-5|CAI41832.1| 777|Homo sapiens ral guanine nucleotide ... 76 3e-13
BC032681-1|AAH32681.1| 777|Homo sapiens ral guanine nucleotide ... 76 3e-13
BC005037-1|AAH05037.1| 644|Homo sapiens RGL2 protein protein. 76 3e-13
AL662827-6|CAI17521.1| 777|Homo sapiens ral guanine nucleotide ... 76 3e-13
AL662820-6|CAI18118.1| 777|Homo sapiens ral guanine nucleotide ... 76 3e-13
AF081197-1|AAF21898.1| 782|Homo sapiens calcium and DAG-regulat... 76 3e-13
AF081195-1|AAC79699.1| 797|Homo sapiens calcium and DAG-regulat... 76 3e-13
BC109297-1|AAI09298.1| 797|Homo sapiens RAS guanyl releasing pr... 76 4e-13
BC109296-1|AAI09297.1| 797|Homo sapiens RAS guanyl releasing pr... 76 4e-13
BC067298-1|AAH67298.1| 765|Homo sapiens RASGRP1 protein protein. 76 4e-13
AY966005-1|AAX76907.1| 481|Homo sapiens RAS guanyl releasing pr... 76 4e-13
AY954625-1|AAX54699.4| 762|Homo sapiens Ras guanyl releasing pr... 76 4e-13
AY858556-1|AAW32406.2| 597|Homo sapiens RAS guanyl releasing pr... 76 4e-13
AY634315-1|AAT47482.2| 546|Homo sapiens Ras guanyl releasing pr... 76 4e-13
AF106071-1|AAC97349.1| 797|Homo sapiens ras activator RasGRP pr... 76 4e-13
BC101110-1|AAI01111.2| 536|Homo sapiens Rgr protein protein. 75 9e-13
BC101108-1|AAI01109.1| 356|Homo sapiens Rgr protein protein. 75 9e-13
BC101109-1|AAI01110.1| 410|Homo sapiens Rgr protein protein. 74 1e-12
BC040275-1|AAH40275.1| 1181|Homo sapiens RASGRF1 protein protein. 74 1e-12
AB208848-1|BAD92085.1| 530|Homo sapiens Ras activator RasGRP va... 72 5e-12
AK131340-1|BAD18497.1| 435|Homo sapiens protein ( Homo sapiens ... 71 1e-11
BC039203-1|AAH39203.1| 444|Homo sapiens RAPGEF5 protein protein. 70 2e-11
BC000316-1|AAH00316.1| 516|Homo sapiens RGL2 protein protein. 68 8e-11
U68142-1|AAC50818.1| 518|Homo sapiens RalGDS-like protein. 67 1e-10
AL162417-9|CAI13414.1| 309|Homo sapiens ral guanine nucleotide ... 64 1e-09
BC057759-1|AAH57759.1| 238|Homo sapiens RasGEF domain family, m... 63 3e-09
BC036802-1|AAH36802.1| 508|Homo sapiens RASGEF1C protein protein. 63 3e-09
AK093160-1|BAC04079.1| 315|Homo sapiens protein ( Homo sapiens ... 63 3e-09
AF449764-1|AAP97676.1| 466|Homo sapiens hypothetical brain prot... 63 3e-09
BC121004-1|AAI21005.1| 431|Homo sapiens RASGEF1B protein protein. 60 2e-08
BC121003-1|AAI21004.1| 472|Homo sapiens RasGEF domain family, m... 60 2e-08
AK056257-1|BAB71130.1| 473|Homo sapiens protein ( Homo sapiens ... 60 2e-08
AC093747-1|AAY40982.1| 336|Homo sapiens unknown protein. 58 8e-08
BC022548-1|AAH22548.2| 481|Homo sapiens RasGEF domain family, m... 51 1e-05
AK095136-1|BAC04491.1| 489|Homo sapiens protein ( Homo sapiens ... 51 1e-05
AL445199-3|CAM24665.1| 1749|Homo sapiens kinase non-catalytic C-... 51 1e-05
AL389885-3|CAH73289.1| 1994|Homo sapiens phospholipase C, epsilo... 51 1e-05
AL389885-2|CAH73288.1| 2312|Homo sapiens phospholipase C, epsilo... 51 1e-05
AL365510-3|CAH73758.1| 1994|Homo sapiens phospholipase C, epsilo... 51 1e-05
AL365510-2|CAH73757.1| 2312|Homo sapiens phospholipase C, epsilo... 51 1e-05
AL139124-2|CAI16675.1| 1994|Homo sapiens phospholipase C, epsilo... 51 1e-05
AL139124-1|CAI16674.1| 2312|Homo sapiens phospholipase C, epsilo... 51 1e-05
AL139118-2|CAH70740.1| 1994|Homo sapiens phospholipase C, epsilo... 51 1e-05
AL139118-1|CAH70739.1| 2312|Homo sapiens phospholipase C, epsilo... 51 1e-05
AK131205-1|BAD18397.1| 491|Homo sapiens protein ( Homo sapiens ... 51 1e-05
AF190642-1|AAG17145.2| 2303|Homo sapiens phosphoinositide-specif... 51 1e-05
AB040949-1|BAA96040.2| 2304|Homo sapiens KIAA1516 protein protein. 51 1e-05
BC047924-1|AAH47924.1| 500|Homo sapiens KNDC1 protein protein. 50 2e-05
AB000781-1|BAD12625.1| 1684|Homo sapiens cerebral protein-9 prot... 50 2e-05
AF170071-1|AAG28341.1| 1994|Homo sapiens phospholipase C epsilon... 50 3e-05
AF295775-1|AAG10221.1| 211|Homo sapiens ral guanine nucleotide ... 46 4e-04
BC019329-1|AAH19329.1| 198|Homo sapiens RALGPS1 protein protein. 45 8e-04
AL160169-7|CAI40644.1| 108|Homo sapiens Ral GEF with PH domain ... 45 8e-04
AK097292-1|BAC04992.1| 202|Homo sapiens protein ( Homo sapiens ... 41 0.010
BC033198-1|AAH33198.1| 411|Homo sapiens Unknown (protein for IM... 37 0.17
AL160276-5|CAI40649.1| 318|Homo sapiens Rap guanine nucleotide ... 36 0.52
AK125459-1|BAC86170.1| 1268|Homo sapiens protein ( Homo sapiens ... 35 0.68
AF225988-1|AAF35390.1| 1980|Homo sapiens voltage-gated sodium ch... 35 0.68
AF050736-1|AAD15789.1| 1980|Homo sapiens voltage-gated sodium ch... 35 0.68
AB209674-1|BAD92911.1| 1947|Homo sapiens T-cell lymphoma invasio... 35 0.68
AB095936-1|BAC23112.2| 1715|Homo sapiens KIAA2016 protein protein. 35 0.68
AB027567-1|BAA78033.1| 1980|Homo sapiens sodium channel protein. 35 0.68
U16296-1|AAA98443.1| 1591|Homo sapiens TIAM1 protein protein. 34 1.2
BC117196-1|AAI17197.1| 1591|Homo sapiens T-cell lymphoma invasio... 34 1.2
BC117192-1|AAI17193.1| 1591|Homo sapiens T-cell lymphoma invasio... 34 1.2
AB209101-1|BAD92338.1| 1060|Homo sapiens T-cell lymphoma invasio... 34 1.2
BC071592-1|AAH71592.1| 1076|Homo sapiens FARP1 protein protein. 34 1.6
BC041595-1|AAH41595.1| 1045|Homo sapiens FERM, RhoGEF (ARHGEF) a... 34 1.6
AL161896-1|CAI12946.1| 1045|Homo sapiens FERM, RhoGEF (ARHGEF) a... 34 1.6
AL137249-8|CAI39458.1| 1045|Homo sapiens FERM, RhoGEF (ARHGEF) a... 34 1.6
AL136300-3|CAI10953.1| 1045|Homo sapiens FERM, RhoGEF (ARHGEF) a... 34 1.6
AB008430-1|BAA24267.1| 1045|Homo sapiens CDEP protein. 34 1.6
BC125226-1|AAI25227.1| 639|Homo sapiens FGD6 protein protein. 33 2.7
BC125225-1|AAI25226.1| 639|Homo sapiens FGD6 protein protein. 33 2.7
BC113555-1|AAI13556.1| 833|Homo sapiens ventricular zone expres... 33 2.7
BC111017-1|AAI11018.1| 788|Homo sapiens VEPH1 protein protein. 33 2.7
BC101660-1|AAI01661.1| 833|Homo sapiens ventricular zone expres... 33 2.7
BC042159-1|AAH42159.1| 459|Homo sapiens VEPH1 protein protein. 33 2.7
BC038976-1|AAH38976.2| 475|Homo sapiens Rho GTPase activating p... 33 2.7
BC016701-1|AAH16701.1| 475|Homo sapiens Rho GTPase activating p... 33 2.7
AY219338-1|AAO34684.1| 475|Homo sapiens ARHGAP15 protein. 33 2.7
AK128492-1|BAC87464.1| 1053|Homo sapiens protein ( Homo sapiens ... 33 2.7
AK124904-1|BAC85990.1| 1430|Homo sapiens protein ( Homo sapiens ... 33 2.7
AK022666-1|BAB14165.1| 173|Homo sapiens protein ( Homo sapiens ... 33 2.7
AK002045-1|BAA92052.1| 432|Homo sapiens protein ( Homo sapiens ... 33 2.7
AB051479-1|BAB21783.1| 855|Homo sapiens KIAA1692 protein protein. 33 2.7
BC014426-1|AAH14426.1| 351|Homo sapiens RGL3 protein protein. 33 3.6
AK027625-1|BAB55243.1| 833|Homo sapiens protein ( Homo sapiens ... 32 4.8
DQ310721-1|ABC40719.1| 606|Homo sapiens nei endonuclease VIII-l... 31 8.4
BC025954-1|AAH25954.1| 605|Homo sapiens nei endonuclease VIII-l... 31 8.4
AK001720-1|BAA91860.1| 605|Homo sapiens protein ( Homo sapiens ... 31 8.4
AC110299-3|AAY14682.1| 300|Homo sapiens unknown protein. 31 8.4
AB079071-1|BAC06479.1| 605|Homo sapiens hypothetical protein pr... 31 8.4
AB018336-1|BAA34513.2| 1055|Homo sapiens KIAA0793 protein protein. 31 8.4
>AL450263-6|CAI41461.1| 557|Homo sapiens Ral GEF with PH domain and
SH3 binding motif 1 protein.
Length = 557
Score = 393 bits (968), Expect = e-109
Identities = 223/527 (42%), Positives = 320/527 (60%), Gaps = 44/527 (8%)
Query: 89 NQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFT 148
++S+D +V L+++P++ +Q+TL+D+P FKAI+PEEL +CGW+K K ++APNVVAFT
Sbjct: 36 SKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFT 95
Query: 149 KRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYR 208
+RFN+VSFW V+EIL Q+ K RAEI++HF+K+AKKL ELNNLHSL +V+SAL SA I+R
Sbjct: 96 RRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFR 155
Query: 209 LTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISL-PCIPYLGIFLTDLVYIDI 267
LTKTWA L++KDK F+KL L + DN+ REY++S+ + P IPYLGI+L DL+YID
Sbjct: 156 LTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDS 215
Query: 268 AHPAG-----SPHRVTKMNIVLKALERYQ-SSEYE-IAPLPHVANFLNSVRYIEELQKFV 320
A+PA + R +MN +L+ + Q S Y+ + LPHV +L SVRYIEELQKFV
Sbjct: 216 AYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFV 275
Query: 321 EDDQYKLSLKLEPPSPVGSCAGSKESVKETVLQGNVTTFNISPSHKLGSGSLRLQGTSHQ 380
EDD YKLSL++EP S SKE + F+ P+ S + L
Sbjct: 276 EDDNYKLSLRIEPGSSSPRLVSSKEDLAGPSAGSGSARFSRRPTCPDTSVAGSLPTPP-- 333
Query: 381 GKFIPTHRKCRSLGSNIF-------GKSHT-----------EDKMDEKTPAGSVNLLDDT 422
+P HRK SLG+N+ KS T + ++ ++P + L +
Sbjct: 334 ---VPRHRKSHSLGNNMMCQLSVVESKSATFPSEKARHLLDDSVLESRSPRRGLALTSSS 390
Query: 423 LLESPSSVACAKMSQSLPH--SNITKPED-IQCDF---------QGCVKRKTILKEGRKI 470
+ + S+ ++ S+ S + P C +G ++RKT+LKEGRK
Sbjct: 391 AVTNGLSLGSSESSEFSEEMSSGLESPTGPCICSLGNSAAVPTMEGPLRRKTLLKEGRKP 450
Query: 471 SLSSWQRYWLQMSGNMLFFYGAKSFKGTNRSDFRSERCKVLTLVGW-IAVWADGDAADAF 529
+LSSW RYW+ +SG+ L +YGAKS +GT+R ++S K +++VGW + + D + D F
Sbjct: 451 ALSSWTRYWVILSGSTLLYYGAKSLRGTDRKHYKSTPGKKVSIVGWMVQLPDDPEHPDIF 510
Query: 530 QLINHHSGTVYKFKAGSEYAAKQWIAKIEEVTNKIVKPLPANLMSFE 576
QL N G VYKF+ GS + A W +++ +PANLMSFE
Sbjct: 511 QLNNPDKGNVYKFQTGSRFHAILWHKHLDDACKSNRPQVPANLMSFE 557
>AL357623-3|CAH72701.1| 557|Homo sapiens Ral GEF with PH domain and
SH3 binding motif 1 protein.
Length = 557
Score = 393 bits (968), Expect = e-109
Identities = 223/527 (42%), Positives = 320/527 (60%), Gaps = 44/527 (8%)
Query: 89 NQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFT 148
++S+D +V L+++P++ +Q+TL+D+P FKAI+PEEL +CGW+K K ++APNVVAFT
Sbjct: 36 SKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFT 95
Query: 149 KRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYR 208
+RFN+VSFW V+EIL Q+ K RAEI++HF+K+AKKL ELNNLHSL +V+SAL SA I+R
Sbjct: 96 RRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFR 155
Query: 209 LTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISL-PCIPYLGIFLTDLVYIDI 267
LTKTWA L++KDK F+KL L + DN+ REY++S+ + P IPYLGI+L DL+YID
Sbjct: 156 LTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDS 215
Query: 268 AHPAG-----SPHRVTKMNIVLKALERYQ-SSEYE-IAPLPHVANFLNSVRYIEELQKFV 320
A+PA + R +MN +L+ + Q S Y+ + LPHV +L SVRYIEELQKFV
Sbjct: 216 AYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFV 275
Query: 321 EDDQYKLSLKLEPPSPVGSCAGSKESVKETVLQGNVTTFNISPSHKLGSGSLRLQGTSHQ 380
EDD YKLSL++EP S SKE + F+ P+ S + L
Sbjct: 276 EDDNYKLSLRIEPGSSSPRLVSSKEDLAGPSAGSGSARFSRRPTCPDTSVAGSLPTPP-- 333
Query: 381 GKFIPTHRKCRSLGSNIF-------GKSHT-----------EDKMDEKTPAGSVNLLDDT 422
+P HRK SLG+N+ KS T + ++ ++P + L +
Sbjct: 334 ---VPRHRKSHSLGNNMMCQLSVVESKSATFPSEKARHLLDDSVLESRSPRRGLALTSSS 390
Query: 423 LLESPSSVACAKMSQSLPH--SNITKPED-IQCDF---------QGCVKRKTILKEGRKI 470
+ + S+ ++ S+ S + P C +G ++RKT+LKEGRK
Sbjct: 391 AVTNGLSLGSSESSEFSEEMSSGLESPTGPCICSLGNSAAVPTMEGPLRRKTLLKEGRKP 450
Query: 471 SLSSWQRYWLQMSGNMLFFYGAKSFKGTNRSDFRSERCKVLTLVGW-IAVWADGDAADAF 529
+LSSW RYW+ +SG+ L +YGAKS +GT+R ++S K +++VGW + + D + D F
Sbjct: 451 ALSSWTRYWVILSGSTLLYYGAKSLRGTDRKHYKSTPGKKVSIVGWMVQLPDDPEHPDIF 510
Query: 530 QLINHHSGTVYKFKAGSEYAAKQWIAKIEEVTNKIVKPLPANLMSFE 576
QL N G VYKF+ GS + A W +++ +PANLMSFE
Sbjct: 511 QLNNPDKGNVYKFQTGSRFHAILWHKHLDDACKSNRPQVPANLMSFE 557
>AL356862-3|CAI39720.1| 557|Homo sapiens Ral GEF with PH domain and
SH3 binding motif 1 protein.
Length = 557
Score = 393 bits (968), Expect = e-109
Identities = 223/527 (42%), Positives = 320/527 (60%), Gaps = 44/527 (8%)
Query: 89 NQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFT 148
++S+D +V L+++P++ +Q+TL+D+P FKAI+PEEL +CGW+K K ++APNVVAFT
Sbjct: 36 SKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFT 95
Query: 149 KRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYR 208
+RFN+VSFW V+EIL Q+ K RAEI++HF+K+AKKL ELNNLHSL +V+SAL SA I+R
Sbjct: 96 RRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFR 155
Query: 209 LTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISL-PCIPYLGIFLTDLVYIDI 267
LTKTWA L++KDK F+KL L + DN+ REY++S+ + P IPYLGI+L DL+YID
Sbjct: 156 LTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDS 215
Query: 268 AHPAG-----SPHRVTKMNIVLKALERYQ-SSEYE-IAPLPHVANFLNSVRYIEELQKFV 320
A+PA + R +MN +L+ + Q S Y+ + LPHV +L SVRYIEELQKFV
Sbjct: 216 AYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFV 275
Query: 321 EDDQYKLSLKLEPPSPVGSCAGSKESVKETVLQGNVTTFNISPSHKLGSGSLRLQGTSHQ 380
EDD YKLSL++EP S SKE + F+ P+ S + L
Sbjct: 276 EDDNYKLSLRIEPGSSSPRLVSSKEDLAGPSAGSGSARFSRRPTCPDTSVAGSLPTPP-- 333
Query: 381 GKFIPTHRKCRSLGSNIF-------GKSHT-----------EDKMDEKTPAGSVNLLDDT 422
+P HRK SLG+N+ KS T + ++ ++P + L +
Sbjct: 334 ---VPRHRKSHSLGNNMMCQLSVVESKSATFPSEKARHLLDDSVLESRSPRRGLALTSSS 390
Query: 423 LLESPSSVACAKMSQSLPH--SNITKPED-IQCDF---------QGCVKRKTILKEGRKI 470
+ + S+ ++ S+ S + P C +G ++RKT+LKEGRK
Sbjct: 391 AVTNGLSLGSSESSEFSEEMSSGLESPTGPCICSLGNSAAVPTMEGPLRRKTLLKEGRKP 450
Query: 471 SLSSWQRYWLQMSGNMLFFYGAKSFKGTNRSDFRSERCKVLTLVGW-IAVWADGDAADAF 529
+LSSW RYW+ +SG+ L +YGAKS +GT+R ++S K +++VGW + + D + D F
Sbjct: 451 ALSSWTRYWVILSGSTLLYYGAKSLRGTDRKHYKSTPGKKVSIVGWMVQLPDDPEHPDIF 510
Query: 530 QLINHHSGTVYKFKAGSEYAAKQWIAKIEEVTNKIVKPLPANLMSFE 576
QL N G VYKF+ GS + A W +++ +PANLMSFE
Sbjct: 511 QLNNPDKGNVYKFQTGSRFHAILWHKHLDDACKSNRPQVPANLMSFE 557
>AL160169-3|CAI40640.1| 557|Homo sapiens Ral GEF with PH domain and
SH3 binding motif 1 protein.
Length = 557
Score = 393 bits (968), Expect = e-109
Identities = 223/527 (42%), Positives = 320/527 (60%), Gaps = 44/527 (8%)
Query: 89 NQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFT 148
++S+D +V L+++P++ +Q+TL+D+P FKAI+PEEL +CGW+K K ++APNVVAFT
Sbjct: 36 SKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFT 95
Query: 149 KRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYR 208
+RFN+VSFW V+EIL Q+ K RAEI++HF+K+AKKL ELNNLHSL +V+SAL SA I+R
Sbjct: 96 RRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFR 155
Query: 209 LTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISL-PCIPYLGIFLTDLVYIDI 267
LTKTWA L++KDK F+KL L + DN+ REY++S+ + P IPYLGI+L DL+YID
Sbjct: 156 LTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDS 215
Query: 268 AHPAG-----SPHRVTKMNIVLKALERYQ-SSEYE-IAPLPHVANFLNSVRYIEELQKFV 320
A+PA + R +MN +L+ + Q S Y+ + LPHV +L SVRYIEELQKFV
Sbjct: 216 AYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFV 275
Query: 321 EDDQYKLSLKLEPPSPVGSCAGSKESVKETVLQGNVTTFNISPSHKLGSGSLRLQGTSHQ 380
EDD YKLSL++EP S SKE + F+ P+ S + L
Sbjct: 276 EDDNYKLSLRIEPGSSSPRLVSSKEDLAGPSAGSGSARFSRRPTCPDTSVAGSLPTPP-- 333
Query: 381 GKFIPTHRKCRSLGSNIF-------GKSHT-----------EDKMDEKTPAGSVNLLDDT 422
+P HRK SLG+N+ KS T + ++ ++P + L +
Sbjct: 334 ---VPRHRKSHSLGNNMMCQLSVVESKSATFPSEKARHLLDDSVLESRSPRRGLALTSSS 390
Query: 423 LLESPSSVACAKMSQSLPH--SNITKPED-IQCDF---------QGCVKRKTILKEGRKI 470
+ + S+ ++ S+ S + P C +G ++RKT+LKEGRK
Sbjct: 391 AVTNGLSLGSSESSEFSEEMSSGLESPTGPCICSLGNSAAVPTMEGPLRRKTLLKEGRKP 450
Query: 471 SLSSWQRYWLQMSGNMLFFYGAKSFKGTNRSDFRSERCKVLTLVGW-IAVWADGDAADAF 529
+LSSW RYW+ +SG+ L +YGAKS +GT+R ++S K +++VGW + + D + D F
Sbjct: 451 ALSSWTRYWVILSGSTLLYYGAKSLRGTDRKHYKSTPGKKVSIVGWMVQLPDDPEHPDIF 510
Query: 530 QLINHHSGTVYKFKAGSEYAAKQWIAKIEEVTNKIVKPLPANLMSFE 576
QL N G VYKF+ GS + A W +++ +PANLMSFE
Sbjct: 511 QLNNPDKGNVYKFQTGSRFHAILWHKHLDDACKSNRPQVPANLMSFE 557
>AB002349-1|BAA20808.2| 590|Homo sapiens KIAA0351 protein.
Length = 590
Score = 393 bits (968), Expect = e-109
Identities = 223/527 (42%), Positives = 320/527 (60%), Gaps = 44/527 (8%)
Query: 89 NQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFT 148
++S+D +V L+++P++ +Q+TL+D+P FKAI+PEEL +CGW+K K ++APNVVAFT
Sbjct: 69 SKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFT 128
Query: 149 KRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYR 208
+RFN+VSFW V+EIL Q+ K RAEI++HF+K+AKKL ELNNLHSL +V+SAL SA I+R
Sbjct: 129 RRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFR 188
Query: 209 LTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISL-PCIPYLGIFLTDLVYIDI 267
LTKTWA L++KDK F+KL L + DN+ REY++S+ + P IPYLGI+L DL+YID
Sbjct: 189 LTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDS 248
Query: 268 AHPAG-----SPHRVTKMNIVLKALERYQ-SSEYE-IAPLPHVANFLNSVRYIEELQKFV 320
A+PA + R +MN +L+ + Q S Y+ + LPHV +L SVRYIEELQKFV
Sbjct: 249 AYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFV 308
Query: 321 EDDQYKLSLKLEPPSPVGSCAGSKESVKETVLQGNVTTFNISPSHKLGSGSLRLQGTSHQ 380
EDD YKLSL++EP S SKE + F+ P+ S + L
Sbjct: 309 EDDNYKLSLRIEPGSSSPRLVSSKEDLAGPSAGSGSARFSRRPTCPDTSVAGSLPTPP-- 366
Query: 381 GKFIPTHRKCRSLGSNIF-------GKSHT-----------EDKMDEKTPAGSVNLLDDT 422
+P HRK SLG+N+ KS T + ++ ++P + L +
Sbjct: 367 ---VPRHRKSHSLGNNMMCQLSVVESKSATFPSEKARHLLDDSVLESRSPRRGLALTSSS 423
Query: 423 LLESPSSVACAKMSQSLPH--SNITKPED-IQCDF---------QGCVKRKTILKEGRKI 470
+ + S+ ++ S+ S + P C +G ++RKT+LKEGRK
Sbjct: 424 AVTNGLSLGSSESSEFSEEMSSGLESPTGPCICSLGNSAAVPTMEGPLRRKTLLKEGRKP 483
Query: 471 SLSSWQRYWLQMSGNMLFFYGAKSFKGTNRSDFRSERCKVLTLVGW-IAVWADGDAADAF 529
+LSSW RYW+ +SG+ L +YGAKS +GT+R ++S K +++VGW + + D + D F
Sbjct: 484 ALSSWTRYWVILSGSTLLYYGAKSLRGTDRKHYKSTPGKKVSIVGWMVQLPDDPEHPDIF 543
Query: 530 QLINHHSGTVYKFKAGSEYAAKQWIAKIEEVTNKIVKPLPANLMSFE 576
QL N G VYKF+ GS + A W +++ +PANLMSFE
Sbjct: 544 QLNNPDKGNVYKFQTGSRFHAILWHKHLDDACKSNRPQVPANLMSFE 590
>AL450263-5|CAI41460.1| 529|Homo sapiens Ral GEF with PH domain and
SH3 binding motif 1 protein.
Length = 529
Score = 374 bits (921), Expect = e-103
Identities = 209/480 (43%), Positives = 299/480 (62%), Gaps = 34/480 (7%)
Query: 89 NQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFT 148
++S+D +V L+++P++ +Q+TL+D+P FKAI+PEEL +CGW+K K ++APNVVAFT
Sbjct: 36 SKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFT 95
Query: 149 KRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYR 208
+RFN+VSFW V+EIL Q+ K RAEI++HF+K+AKKL ELNNLHSL +V+SAL SA I+R
Sbjct: 96 RRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFR 155
Query: 209 LTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISL-PCIPYLGIFLTDLVYIDI 267
LTKTWA L++KDK F+KL L + DN+ REY++S+ + P IPYLGI+L DL+YID
Sbjct: 156 LTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDS 215
Query: 268 AHPAG-----SPHRVTKMNIVLKALERYQ-SSEYE-IAPLPHVANFLNSVRYIEELQKFV 320
A+PA + R +MN +L+ + Q S Y+ + LPHV +L SVRYIEELQKFV
Sbjct: 216 AYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFV 275
Query: 321 EDDQYKLSLKLEPPSPVGSCAGSKESVKETVLQGNVTTFNISPSHKLGSGSLRLQGTSHQ 380
EDD YKLSL++EP S SKE + F+ P+ S + L
Sbjct: 276 EDDNYKLSLRIEPGSSSPRLVSSKEDLAGPSAGSGSARFSRRPTCPDTSVAGSLPTPP-- 333
Query: 381 GKFIPTHRKCRSLGSNIFGKSHTEDKMDEKTPAGSVNLLDDTLLESPSSVACAKMSQSLP 440
+P HRK SLG+N G+ + + + P + + + + SP+ + S
Sbjct: 334 ---VPRHRKSHSLGNN-RGRLYATLGPNWRVPVRN-SPRTRSCVYSPTGPCICSLGNSAA 388
Query: 441 HSNITKPEDIQCDFQGCVKRKTILKEGRKISLSSWQRYWLQMSGNMLFFYGAKSFKGTNR 500
+ +G ++RKT+LKEGRK +LSSW RYW+ +SG+ L +YGAKS +GT+R
Sbjct: 389 VPTM----------EGPLRRKTLLKEGRKPALSSWTRYWVILSGSTLLYYGAKSLRGTDR 438
Query: 501 SDFRSERCKVLTLVGW-IAVWADGDAADAFQLINHHSGTVYKFKAGSEYAAKQWIAKIEE 559
K +++VGW + + D + D FQL N G VYKF+ GS + A W +++
Sbjct: 439 --------KHVSIVGWMVQLPDDPEHPDIFQLNNPDKGNVYKFQTGSRFHAILWHKHLDD 490
>AL357623-2|CAH72700.1| 529|Homo sapiens Ral GEF with PH domain and
SH3 binding motif 1 protein.
Length = 529
Score = 374 bits (921), Expect = e-103
Identities = 209/480 (43%), Positives = 299/480 (62%), Gaps = 34/480 (7%)
Query: 89 NQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFT 148
++S+D +V L+++P++ +Q+TL+D+P FKAI+PEEL +CGW+K K ++APNVVAFT
Sbjct: 36 SKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFT 95
Query: 149 KRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYR 208
+RFN+VSFW V+EIL Q+ K RAEI++HF+K+AKKL ELNNLHSL +V+SAL SA I+R
Sbjct: 96 RRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFR 155
Query: 209 LTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISL-PCIPYLGIFLTDLVYIDI 267
LTKTWA L++KDK F+KL L + DN+ REY++S+ + P IPYLGI+L DL+YID
Sbjct: 156 LTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDS 215
Query: 268 AHPAG-----SPHRVTKMNIVLKALERYQ-SSEYE-IAPLPHVANFLNSVRYIEELQKFV 320
A+PA + R +MN +L+ + Q S Y+ + LPHV +L SVRYIEELQKFV
Sbjct: 216 AYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFV 275
Query: 321 EDDQYKLSLKLEPPSPVGSCAGSKESVKETVLQGNVTTFNISPSHKLGSGSLRLQGTSHQ 380
EDD YKLSL++EP S SKE + F+ P+ S + L
Sbjct: 276 EDDNYKLSLRIEPGSSSPRLVSSKEDLAGPSAGSGSARFSRRPTCPDTSVAGSLPTPP-- 333
Query: 381 GKFIPTHRKCRSLGSNIFGKSHTEDKMDEKTPAGSVNLLDDTLLESPSSVACAKMSQSLP 440
+P HRK SLG+N G+ + + + P + + + + SP+ + S
Sbjct: 334 ---VPRHRKSHSLGNN-RGRLYATLGPNWRVPVRN-SPRTRSCVYSPTGPCICSLGNSAA 388
Query: 441 HSNITKPEDIQCDFQGCVKRKTILKEGRKISLSSWQRYWLQMSGNMLFFYGAKSFKGTNR 500
+ +G ++RKT+LKEGRK +LSSW RYW+ +SG+ L +YGAKS +GT+R
Sbjct: 389 VPTM----------EGPLRRKTLLKEGRKPALSSWTRYWVILSGSTLLYYGAKSLRGTDR 438
Query: 501 SDFRSERCKVLTLVGW-IAVWADGDAADAFQLINHHSGTVYKFKAGSEYAAKQWIAKIEE 559
K +++VGW + + D + D FQL N G VYKF+ GS + A W +++
Sbjct: 439 --------KHVSIVGWMVQLPDDPEHPDIFQLNNPDKGNVYKFQTGSRFHAILWHKHLDD 490
>AL356862-2|CAI39719.1| 529|Homo sapiens Ral GEF with PH domain and
SH3 binding motif 1 protein.
Length = 529
Score = 374 bits (921), Expect = e-103
Identities = 209/480 (43%), Positives = 299/480 (62%), Gaps = 34/480 (7%)
Query: 89 NQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFT 148
++S+D +V L+++P++ +Q+TL+D+P FKAI+PEEL +CGW+K K ++APNVVAFT
Sbjct: 36 SKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFT 95
Query: 149 KRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYR 208
+RFN+VSFW V+EIL Q+ K RAEI++HF+K+AKKL ELNNLHSL +V+SAL SA I+R
Sbjct: 96 RRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFR 155
Query: 209 LTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISL-PCIPYLGIFLTDLVYIDI 267
LTKTWA L++KDK F+KL L + DN+ REY++S+ + P IPYLGI+L DL+YID
Sbjct: 156 LTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDS 215
Query: 268 AHPAG-----SPHRVTKMNIVLKALERYQ-SSEYE-IAPLPHVANFLNSVRYIEELQKFV 320
A+PA + R +MN +L+ + Q S Y+ + LPHV +L SVRYIEELQKFV
Sbjct: 216 AYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFV 275
Query: 321 EDDQYKLSLKLEPPSPVGSCAGSKESVKETVLQGNVTTFNISPSHKLGSGSLRLQGTSHQ 380
EDD YKLSL++EP S SKE + F+ P+ S + L
Sbjct: 276 EDDNYKLSLRIEPGSSSPRLVSSKEDLAGPSAGSGSARFSRRPTCPDTSVAGSLPTPP-- 333
Query: 381 GKFIPTHRKCRSLGSNIFGKSHTEDKMDEKTPAGSVNLLDDTLLESPSSVACAKMSQSLP 440
+P HRK SLG+N G+ + + + P + + + + SP+ + S
Sbjct: 334 ---VPRHRKSHSLGNN-RGRLYATLGPNWRVPVRN-SPRTRSCVYSPTGPCICSLGNSAA 388
Query: 441 HSNITKPEDIQCDFQGCVKRKTILKEGRKISLSSWQRYWLQMSGNMLFFYGAKSFKGTNR 500
+ +G ++RKT+LKEGRK +LSSW RYW+ +SG+ L +YGAKS +GT+R
Sbjct: 389 VPTM----------EGPLRRKTLLKEGRKPALSSWTRYWVILSGSTLLYYGAKSLRGTDR 438
Query: 501 SDFRSERCKVLTLVGW-IAVWADGDAADAFQLINHHSGTVYKFKAGSEYAAKQWIAKIEE 559
K +++VGW + + D + D FQL N G VYKF+ GS + A W +++
Sbjct: 439 --------KHVSIVGWMVQLPDDPEHPDIFQLNNPDKGNVYKFQTGSRFHAILWHKHLDD 490
>AL160169-2|CAI40639.1| 529|Homo sapiens Ral GEF with PH domain and
SH3 binding motif 1 protein.
Length = 529
Score = 374 bits (921), Expect = e-103
Identities = 209/480 (43%), Positives = 299/480 (62%), Gaps = 34/480 (7%)
Query: 89 NQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFT 148
++S+D +V L+++P++ +Q+TL+D+P FKAI+PEEL +CGW+K K ++APNVVAFT
Sbjct: 36 SKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFT 95
Query: 149 KRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYR 208
+RFN+VSFW V+EIL Q+ K RAEI++HF+K+AKKL ELNNLHSL +V+SAL SA I+R
Sbjct: 96 RRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFR 155
Query: 209 LTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISL-PCIPYLGIFLTDLVYIDI 267
LTKTWA L++KDK F+KL L + DN+ REY++S+ + P IPYLGI+L DL+YID
Sbjct: 156 LTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDS 215
Query: 268 AHPAG-----SPHRVTKMNIVLKALERYQ-SSEYE-IAPLPHVANFLNSVRYIEELQKFV 320
A+PA + R +MN +L+ + Q S Y+ + LPHV +L SVRYIEELQKFV
Sbjct: 216 AYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFV 275
Query: 321 EDDQYKLSLKLEPPSPVGSCAGSKESVKETVLQGNVTTFNISPSHKLGSGSLRLQGTSHQ 380
EDD YKLSL++EP S SKE + F+ P+ S + L
Sbjct: 276 EDDNYKLSLRIEPGSSSPRLVSSKEDLAGPSAGSGSARFSRRPTCPDTSVAGSLPTPP-- 333
Query: 381 GKFIPTHRKCRSLGSNIFGKSHTEDKMDEKTPAGSVNLLDDTLLESPSSVACAKMSQSLP 440
+P HRK SLG+N G+ + + + P + + + + SP+ + S
Sbjct: 334 ---VPRHRKSHSLGNN-RGRLYATLGPNWRVPVRN-SPRTRSCVYSPTGPCICSLGNSAA 388
Query: 441 HSNITKPEDIQCDFQGCVKRKTILKEGRKISLSSWQRYWLQMSGNMLFFYGAKSFKGTNR 500
+ +G ++RKT+LKEGRK +LSSW RYW+ +SG+ L +YGAKS +GT+R
Sbjct: 389 VPTM----------EGPLRRKTLLKEGRKPALSSWTRYWVILSGSTLLYYGAKSLRGTDR 438
Query: 501 SDFRSERCKVLTLVGW-IAVWADGDAADAFQLINHHSGTVYKFKAGSEYAAKQWIAKIEE 559
K +++VGW + + D + D FQL N G VYKF+ GS + A W +++
Sbjct: 439 --------KHVSIVGWMVQLPDDPEHPDIFQLNNPDKGNVYKFQTGSRFHAILWHKHLDD 490
>AF221098-1|AAF65253.1| 529|Homo sapiens Ral guanine nucleotide
exchange factor RalGPS1A protein.
Length = 529
Score = 374 bits (921), Expect = e-103
Identities = 209/480 (43%), Positives = 299/480 (62%), Gaps = 34/480 (7%)
Query: 89 NQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFT 148
++S+D +V L+++P++ +Q+TL+D+P FKAI+PEEL +CGW+K K ++APNVVAFT
Sbjct: 36 SKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFT 95
Query: 149 KRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYR 208
+RFN+VSFW V+EIL Q+ K RAEI++HF+K+AKKL ELNNLHSL +V+SAL SA I+R
Sbjct: 96 RRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFR 155
Query: 209 LTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISL-PCIPYLGIFLTDLVYIDI 267
LTKTWA L++KDK F+KL L + DN+ REY++S+ + P IPYLGI+L DL+YID
Sbjct: 156 LTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDS 215
Query: 268 AHPAG-----SPHRVTKMNIVLKALERYQ-SSEYE-IAPLPHVANFLNSVRYIEELQKFV 320
A+PA + R +MN +L+ + Q S Y+ + LPHV +L SVRYIEELQKFV
Sbjct: 216 AYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFV 275
Query: 321 EDDQYKLSLKLEPPSPVGSCAGSKESVKETVLQGNVTTFNISPSHKLGSGSLRLQGTSHQ 380
EDD YKLSL++EP S SKE + F+ P+ S + L
Sbjct: 276 EDDNYKLSLRIEPGSSSPRLVSSKEDLAGPSAGSGSARFSRRPTCPDTSVAGSLPTPP-- 333
Query: 381 GKFIPTHRKCRSLGSNIFGKSHTEDKMDEKTPAGSVNLLDDTLLESPSSVACAKMSQSLP 440
+P HRK SLG+N G+ + + + P + + + + SP+ + S
Sbjct: 334 ---VPRHRKSHSLGNN-RGRLYATLGPNWRVPVRN-SPRTRSCVYSPTGPCICSLGNSAA 388
Query: 441 HSNITKPEDIQCDFQGCVKRKTILKEGRKISLSSWQRYWLQMSGNMLFFYGAKSFKGTNR 500
+ +G ++RKT+LKEGRK +LSSW RYW+ +SG+ L +YGAKS +GT+R
Sbjct: 389 VPTM----------EGPLRRKTLLKEGRKPALSSWTRYWVILSGSTLLYYGAKSLRGTDR 438
Query: 501 SDFRSERCKVLTLVGW-IAVWADGDAADAFQLINHHSGTVYKFKAGSEYAAKQWIAKIEE 559
K +++VGW + + D + D FQL N G VYKF+ GS + A W +++
Sbjct: 439 --------KHVSIVGWMVQLPDDPEHPDIFQLNNPDKGNVYKFQTGSRFHAILWHKHLDD 490
>BC047391-1|AAH47391.1| 583|Homo sapiens Ral GEF with PH domain and
SH3 binding motif 2 protein.
Length = 583
Score = 325 bits (798), Expect = 3e-88
Identities = 169/347 (48%), Positives = 233/347 (67%), Gaps = 12/347 (3%)
Query: 88 INQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAF 147
+ +S+D +V L+++P++ Q+TL+D+P FKAI+P+EL++CGW K K + APN VAF
Sbjct: 34 LKKSFDAVVFDVLKVTPEEYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSSAPNAVAF 93
Query: 148 TKRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIY 207
T+RFN VSFW V+EIL+ Q+ K RAE+++H+IK AKKL+ELNNLH+L AV+S L SA I+
Sbjct: 94 TRRFNHVSFWVVREILHAQTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIF 153
Query: 208 RLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISL-PCIPYLGIFLTDLVYID 266
RLTKTWA LS+KDK F+KL + + DN+ LR+Y+ S+ + PCIPYLGI+L+DL YID
Sbjct: 154 RLTKTWALLSRKDKTTFEKLEYVMSKEDNYKRLRDYISSLKMTPCIPYLGIYLSDLTYID 213
Query: 267 IAHPA-GS----PHRVTKMNIVLKAL-ERYQSSEYEIAPLPHVANFLNSVRYIEELQKFV 320
A+P+ GS R MN +L+ + + QS EY+I LPHV +LNSV+YIEELQKFV
Sbjct: 214 SAYPSTGSILENEQRSNLMNNILRIISDLQQSCEYDIPMLPHVQKYLNSVQYIEELQKFV 273
Query: 321 EDDQYKLSLKLEPPSPVGSCAGSKESVKETVLQGNVTTFNISPSHKLGSGSLRLQGTSHQ 380
EDD YKLSLK+EP + A S+E + + + + S + G+L Q
Sbjct: 274 EDDNYKLSLKIEPGTSTPRSAASREDLVGPEVGASPQSGRKSVA---AEGALLPQTPPSP 330
Query: 381 GKFIP-THRKCRSLGSNIFGKSHTEDKMDEKTP-AGSVNLLDDTLLE 425
IP HRKC SLG N K +T + P AG +LLDD+++E
Sbjct: 331 RNLIPHGHRKCHSLGYNFIHKMNTAEFKSATFPNAGPRHLLDDSVME 377
Score = 107 bits (256), Expect = 1e-22
Identities = 48/123 (39%), Positives = 73/123 (59%), Gaps = 1/123 (0%)
Query: 455 QGCVKRKTILKEGRKISLSSWQRYWLQMSGNMLFFYGAKSFKGTNRSDFRSERCKVLTLV 514
QG ++RKT+LKEG+K +++SW +YW + G LF+Y AKS K T R F+S K ++++
Sbjct: 461 QGVLRRKTLLKEGKKPTVASWTKYWAALCGTQLFYYAAKSLKATERKHFKSTSNKNVSVI 520
Query: 515 GWIAVWADG-DAADAFQLINHHSGTVYKFKAGSEYAAKQWIAKIEEVTNKIVKPLPANLM 573
GW+ + AD + D F L + G YKF+AG+ A W + + +P NLM
Sbjct: 521 GWMVMMADDPEHPDLFLLTDSEKGNSYKFQAGNRMNAMLWFKHLSAACQSNKQQVPTNLM 580
Query: 574 SFE 576
+FE
Sbjct: 581 TFE 583
>AL355520-3|CAI21920.1| 583|Homo sapiens Ral GEF with PH domain and
SH3 binding motif 2 protein.
Length = 583
Score = 325 bits (798), Expect = 3e-88
Identities = 169/347 (48%), Positives = 233/347 (67%), Gaps = 12/347 (3%)
Query: 88 INQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAF 147
+ +S+D +V L+++P++ Q+TL+D+P FKAI+P+EL++CGW K K + APN VAF
Sbjct: 34 LKKSFDAVVFDVLKVTPEEYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSSAPNAVAF 93
Query: 148 TKRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIY 207
T+RFN VSFW V+EIL+ Q+ K RAE+++H+IK AKKL+ELNNLH+L AV+S L SA I+
Sbjct: 94 TRRFNHVSFWVVREILHAQTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIF 153
Query: 208 RLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISL-PCIPYLGIFLTDLVYID 266
RLTKTWA LS+KDK F+KL + + DN+ LR+Y+ S+ + PCIPYLGI+L+DL YID
Sbjct: 154 RLTKTWALLSRKDKTTFEKLEYVMSKEDNYKRLRDYISSLKMTPCIPYLGIYLSDLTYID 213
Query: 267 IAHPA-GS----PHRVTKMNIVLKAL-ERYQSSEYEIAPLPHVANFLNSVRYIEELQKFV 320
A+P+ GS R MN +L+ + + QS EY+I LPHV +LNSV+YIEELQKFV
Sbjct: 214 SAYPSTGSILENEQRSNLMNNILRIISDLQQSCEYDIPMLPHVQKYLNSVQYIEELQKFV 273
Query: 321 EDDQYKLSLKLEPPSPVGSCAGSKESVKETVLQGNVTTFNISPSHKLGSGSLRLQGTSHQ 380
EDD YKLSLK+EP + A S+E + + + + S + G+L Q
Sbjct: 274 EDDNYKLSLKIEPGTSTPRSAASREDLVGPEVGASPQSGRKSVA---AEGALLPQTPPSP 330
Query: 381 GKFIP-THRKCRSLGSNIFGKSHTEDKMDEKTP-AGSVNLLDDTLLE 425
IP HRKC SLG N K +T + P AG +LLDD+++E
Sbjct: 331 RNLIPHGHRKCHSLGYNFIHKMNTAEFKSATFPNAGPRHLLDDSVME 377
Score = 107 bits (256), Expect = 1e-22
Identities = 48/123 (39%), Positives = 73/123 (59%), Gaps = 1/123 (0%)
Query: 455 QGCVKRKTILKEGRKISLSSWQRYWLQMSGNMLFFYGAKSFKGTNRSDFRSERCKVLTLV 514
QG ++RKT+LKEG+K +++SW +YW + G LF+Y AKS K T R F+S K ++++
Sbjct: 461 QGVLRRKTLLKEGKKPTVASWTKYWAALCGTQLFYYAAKSLKATERKHFKSTSNKNVSVI 520
Query: 515 GWIAVWADG-DAADAFQLINHHSGTVYKFKAGSEYAAKQWIAKIEEVTNKIVKPLPANLM 573
GW+ + AD + D F L + G YKF+AG+ A W + + +P NLM
Sbjct: 521 GWMVMMADDPEHPDLFLLTDSEKGNSYKFQAGNRMNAMLWFKHLSAACQSNKQQVPTNLM 580
Query: 574 SFE 576
+FE
Sbjct: 581 TFE 583
>AL162255-3|CAH71097.1| 583|Homo sapiens Ral GEF with PH domain and
SH3 binding motif 2 protein.
Length = 583
Score = 325 bits (798), Expect = 3e-88
Identities = 169/347 (48%), Positives = 233/347 (67%), Gaps = 12/347 (3%)
Query: 88 INQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAF 147
+ +S+D +V L+++P++ Q+TL+D+P FKAI+P+EL++CGW K K + APN VAF
Sbjct: 34 LKKSFDAVVFDVLKVTPEEYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSSAPNAVAF 93
Query: 148 TKRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIY 207
T+RFN VSFW V+EIL+ Q+ K RAE+++H+IK AKKL+ELNNLH+L AV+S L SA I+
Sbjct: 94 TRRFNHVSFWVVREILHAQTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIF 153
Query: 208 RLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISL-PCIPYLGIFLTDLVYID 266
RLTKTWA LS+KDK F+KL + + DN+ LR+Y+ S+ + PCIPYLGI+L+DL YID
Sbjct: 154 RLTKTWALLSRKDKTTFEKLEYVMSKEDNYKRLRDYISSLKMTPCIPYLGIYLSDLTYID 213
Query: 267 IAHPA-GS----PHRVTKMNIVLKAL-ERYQSSEYEIAPLPHVANFLNSVRYIEELQKFV 320
A+P+ GS R MN +L+ + + QS EY+I LPHV +LNSV+YIEELQKFV
Sbjct: 214 SAYPSTGSILENEQRSNLMNNILRIISDLQQSCEYDIPMLPHVQKYLNSVQYIEELQKFV 273
Query: 321 EDDQYKLSLKLEPPSPVGSCAGSKESVKETVLQGNVTTFNISPSHKLGSGSLRLQGTSHQ 380
EDD YKLSLK+EP + A S+E + + + + S + G+L Q
Sbjct: 274 EDDNYKLSLKIEPGTSTPRSAASREDLVGPEVGASPQSGRKSVA---AEGALLPQTPPSP 330
Query: 381 GKFIP-THRKCRSLGSNIFGKSHTEDKMDEKTP-AGSVNLLDDTLLE 425
IP HRKC SLG N K +T + P AG +LLDD+++E
Sbjct: 331 RNLIPHGHRKCHSLGYNFIHKMNTAEFKSATFPNAGPRHLLDDSVME 377
Score = 107 bits (256), Expect = 1e-22
Identities = 48/123 (39%), Positives = 73/123 (59%), Gaps = 1/123 (0%)
Query: 455 QGCVKRKTILKEGRKISLSSWQRYWLQMSGNMLFFYGAKSFKGTNRSDFRSERCKVLTLV 514
QG ++RKT+LKEG+K +++SW +YW + G LF+Y AKS K T R F+S K ++++
Sbjct: 461 QGVLRRKTLLKEGKKPTVASWTKYWAALCGTQLFYYAAKSLKATERKHFKSTSNKNVSVI 520
Query: 515 GWIAVWADG-DAADAFQLINHHSGTVYKFKAGSEYAAKQWIAKIEEVTNKIVKPLPANLM 573
GW+ + AD + D F L + G YKF+AG+ A W + + +P NLM
Sbjct: 521 GWMVMMADDPEHPDLFLLTDSEKGNSYKFQAGNRMNAMLWFKHLSAACQSNKQQVPTNLM 580
Query: 574 SFE 576
+FE
Sbjct: 581 TFE 583
>AL355520-2|CAI21919.1| 548|Homo sapiens Ral GEF with PH domain and
SH3 binding motif 2 protein.
Length = 548
Score = 311 bits (764), Expect = 4e-84
Identities = 165/337 (48%), Positives = 224/337 (66%), Gaps = 12/337 (3%)
Query: 98 SALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFW 157
S++ ++ Q+TL+D+P FKAI+P+EL++CGW K K + APN VAFT+RFN VSFW
Sbjct: 9 SSVNIAATASEGQITLMDVPVFKAIQPDELSSCGWNKKEKYSSAPNAVAFTRRFNHVSFW 68
Query: 158 TVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLS 217
V+EIL+ Q+ K RAE+++H+IK AKKL+ELNNLH+L AV+S L SA I+RLTKTWA LS
Sbjct: 69 VVREILHAQTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTWALLS 128
Query: 218 KKDKQQFDKLAELFGETDNWTALREYLKSISL-PCIPYLGIFLTDLVYIDIAHPA-GS-- 273
+KDK F+KL + + DN+ LR+Y+ S+ + PCIPYLGI+L+DL YID A+P+ GS
Sbjct: 129 RKDKTTFEKLEYVMSKEDNYKRLRDYISSLKMTPCIPYLGIYLSDLTYIDSAYPSTGSIL 188
Query: 274 --PHRVTKMNIVLKAL-ERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLK 330
R MN +L+ + + QS EY+I LPHV +LNSV+YIEELQKFVEDD YKLSLK
Sbjct: 189 ENEQRSNLMNNILRIISDLQQSCEYDIPMLPHVQKYLNSVQYIEELQKFVEDDNYKLSLK 248
Query: 331 LEPPSPVGSCAGSKESVKETVLQGNVTTFNISPSHKLGSGSLRLQGTSHQGKFIP-THRK 389
+EP + A S+E + + + + S + G+L Q IP HRK
Sbjct: 249 IEPGTSTPRSAASREDLVGPEVGASPQSGRKSVA---AEGALLPQTPPSPRNLIPHGHRK 305
Query: 390 CRSLGSNIFGKSHTEDKMDEKTP-AGSVNLLDDTLLE 425
C SLG N K +T + P AG +LLDD+++E
Sbjct: 306 CHSLGYNFIHKMNTAEFKSATFPNAGPRHLLDDSVME 342
Score = 107 bits (256), Expect = 1e-22
Identities = 48/123 (39%), Positives = 73/123 (59%), Gaps = 1/123 (0%)
Query: 455 QGCVKRKTILKEGRKISLSSWQRYWLQMSGNMLFFYGAKSFKGTNRSDFRSERCKVLTLV 514
QG ++RKT+LKEG+K +++SW +YW + G LF+Y AKS K T R F+S K ++++
Sbjct: 426 QGVLRRKTLLKEGKKPTVASWTKYWAALCGTQLFYYAAKSLKATERKHFKSTSNKNVSVI 485
Query: 515 GWIAVWADG-DAADAFQLINHHSGTVYKFKAGSEYAAKQWIAKIEEVTNKIVKPLPANLM 573
GW+ + AD + D F L + G YKF+AG+ A W + + +P NLM
Sbjct: 486 GWMVMMADDPEHPDLFLLTDSEKGNSYKFQAGNRMNAMLWFKHLSAACQSNKQQVPTNLM 545
Query: 574 SFE 576
+FE
Sbjct: 546 TFE 548
>AL162255-4|CAH71098.1| 548|Homo sapiens Ral GEF with PH domain and
SH3 binding motif 2 protein.
Length = 548
Score = 311 bits (764), Expect = 4e-84
Identities = 165/337 (48%), Positives = 224/337 (66%), Gaps = 12/337 (3%)
Query: 98 SALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFW 157
S++ ++ Q+TL+D+P FKAI+P+EL++CGW K K + APN VAFT+RFN VSFW
Sbjct: 9 SSVNIAATASEGQITLMDVPVFKAIQPDELSSCGWNKKEKYSSAPNAVAFTRRFNHVSFW 68
Query: 158 TVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLS 217
V+EIL+ Q+ K RAE+++H+IK AKKL+ELNNLH+L AV+S L SA I+RLTKTWA LS
Sbjct: 69 VVREILHAQTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTWALLS 128
Query: 218 KKDKQQFDKLAELFGETDNWTALREYLKSISL-PCIPYLGIFLTDLVYIDIAHPA-GS-- 273
+KDK F+KL + + DN+ LR+Y+ S+ + PCIPYLGI+L+DL YID A+P+ GS
Sbjct: 129 RKDKTTFEKLEYVMSKEDNYKRLRDYISSLKMTPCIPYLGIYLSDLTYIDSAYPSTGSIL 188
Query: 274 --PHRVTKMNIVLKAL-ERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLK 330
R MN +L+ + + QS EY+I LPHV +LNSV+YIEELQKFVEDD YKLSLK
Sbjct: 189 ENEQRSNLMNNILRIISDLQQSCEYDIPMLPHVQKYLNSVQYIEELQKFVEDDNYKLSLK 248
Query: 331 LEPPSPVGSCAGSKESVKETVLQGNVTTFNISPSHKLGSGSLRLQGTSHQGKFIP-THRK 389
+EP + A S+E + + + + S + G+L Q IP HRK
Sbjct: 249 IEPGTSTPRSAASREDLVGPEVGASPQSGRKSVA---AEGALLPQTPPSPRNLIPHGHRK 305
Query: 390 CRSLGSNIFGKSHTEDKMDEKTP-AGSVNLLDDTLLE 425
C SLG N K +T + P AG +LLDD+++E
Sbjct: 306 CHSLGYNFIHKMNTAEFKSATFPNAGPRHLLDDSVME 342
Score = 107 bits (256), Expect = 1e-22
Identities = 48/123 (39%), Positives = 73/123 (59%), Gaps = 1/123 (0%)
Query: 455 QGCVKRKTILKEGRKISLSSWQRYWLQMSGNMLFFYGAKSFKGTNRSDFRSERCKVLTLV 514
QG ++RKT+LKEG+K +++SW +YW + G LF+Y AKS K T R F+S K ++++
Sbjct: 426 QGVLRRKTLLKEGKKPTVASWTKYWAALCGTQLFYYAAKSLKATERKHFKSTSNKNVSVI 485
Query: 515 GWIAVWADG-DAADAFQLINHHSGTVYKFKAGSEYAAKQWIAKIEEVTNKIVKPLPANLM 573
GW+ + AD + D F L + G YKF+AG+ A W + + +P NLM
Sbjct: 486 GWMVMMADDPEHPDLFLLTDSEKGNSYKFQAGNRMNAMLWFKHLSAACQSNKQQVPTNLM 545
Query: 574 SFE 576
+FE
Sbjct: 546 TFE 548
>BC032372-1|AAH32372.1| 305|Homo sapiens RALGPS1 protein protein.
Length = 305
Score = 300 bits (737), Expect = 7e-81
Identities = 146/267 (54%), Positives = 197/267 (73%), Gaps = 8/267 (2%)
Query: 89 NQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFT 148
++S+D +V L+++P++ +Q+TL+D+P FKAI+PEEL +CGW+K K T+APNVVAFT
Sbjct: 36 SKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHTLAPNVVAFT 95
Query: 149 KRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYR 208
+RFN+VSFW V+EIL Q+ K RAEI++HF+K+AKKL ELNNLHSL +V+SAL SA I+R
Sbjct: 96 RRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFR 155
Query: 209 LTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISL-PCIPYLGIFLTDLVYIDI 267
LTKTWA L++KDK F+KL L + DN+ REY++S+ + P IPYLGI+L DL+YID
Sbjct: 156 LTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDS 215
Query: 268 AHPAG-----SPHRVTKMNIVLKALERYQ-SSEYE-IAPLPHVANFLNSVRYIEELQKFV 320
A+PA + R +MN +L+ + Q S Y+ + LPHV +L SVRYIEELQKFV
Sbjct: 216 AYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFV 275
Query: 321 EDDQYKLSLKLEPPSPVGSCAGSKESV 347
EDD YKLSL++EP S SKE +
Sbjct: 276 EDDNYKLSLRIEPGSSSPRLVSSKEDL 302
>BC033708-1|AAH33708.1| 384|Homo sapiens RALGPS1 protein protein.
Length = 384
Score = 299 bits (733), Expect = 2e-80
Identities = 145/267 (54%), Positives = 197/267 (73%), Gaps = 8/267 (2%)
Query: 89 NQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFT 148
++S+D +V L+++P++ +Q+TL+D+P FKAI+PEEL +CGW+K K ++APNVVAFT
Sbjct: 36 SKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFT 95
Query: 149 KRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYR 208
+RFN+VSFW V+EIL Q+ K RAEI++HF+K+AKKL ELNNLHSL +V+SAL SA I+R
Sbjct: 96 RRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFR 155
Query: 209 LTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISL-PCIPYLGIFLTDLVYIDI 267
LTKTWA L++KDK F+KL L + DN+ REY++S+ + P IPYLGI+L DL+YID
Sbjct: 156 LTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDS 215
Query: 268 AHPAG-----SPHRVTKMNIVLKALERYQ-SSEYE-IAPLPHVANFLNSVRYIEELQKFV 320
A+PA + R +MN +L+ + Q S Y+ + LPHV +L SVRYIEELQKFV
Sbjct: 216 AYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFV 275
Query: 321 EDDQYKLSLKLEPPSPVGSCAGSKESV 347
EDD YKLSL++EP S SKE +
Sbjct: 276 EDDNYKLSLRIEPGSSSPRLVSSKEDL 302
>AL357623-4|CAH72702.1| 384|Homo sapiens Ral GEF with PH domain and
SH3 binding motif 1 protein.
Length = 384
Score = 299 bits (733), Expect = 2e-80
Identities = 145/267 (54%), Positives = 197/267 (73%), Gaps = 8/267 (2%)
Query: 89 NQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFT 148
++S+D +V L+++P++ +Q+TL+D+P FKAI+PEEL +CGW+K K ++APNVVAFT
Sbjct: 36 SKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFT 95
Query: 149 KRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYR 208
+RFN+VSFW V+EIL Q+ K RAEI++HF+K+AKKL ELNNLHSL +V+SAL SA I+R
Sbjct: 96 RRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFR 155
Query: 209 LTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISL-PCIPYLGIFLTDLVYIDI 267
LTKTWA L++KDK F+KL L + DN+ REY++S+ + P IPYLGI+L DL+YID
Sbjct: 156 LTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDS 215
Query: 268 AHPAG-----SPHRVTKMNIVLKALERYQ-SSEYE-IAPLPHVANFLNSVRYIEELQKFV 320
A+PA + R +MN +L+ + Q S Y+ + LPHV +L SVRYIEELQKFV
Sbjct: 216 AYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFV 275
Query: 321 EDDQYKLSLKLEPPSPVGSCAGSKESV 347
EDD YKLSL++EP S SKE +
Sbjct: 276 EDDNYKLSLRIEPGSSSPRLVSSKEDL 302
>AL357623-1|CAH72699.1| 305|Homo sapiens Ral GEF with PH domain and
SH3 binding motif 1 protein.
Length = 305
Score = 299 bits (733), Expect = 2e-80
Identities = 145/267 (54%), Positives = 197/267 (73%), Gaps = 8/267 (2%)
Query: 89 NQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFT 148
++S+D +V L+++P++ +Q+TL+D+P FKAI+PEEL +CGW+K K ++APNVVAFT
Sbjct: 36 SKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFT 95
Query: 149 KRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYR 208
+RFN+VSFW V+EIL Q+ K RAEI++HF+K+AKKL ELNNLHSL +V+SAL SA I+R
Sbjct: 96 RRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFR 155
Query: 209 LTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISL-PCIPYLGIFLTDLVYIDI 267
LTKTWA L++KDK F+KL L + DN+ REY++S+ + P IPYLGI+L DL+YID
Sbjct: 156 LTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDS 215
Query: 268 AHPAG-----SPHRVTKMNIVLKALERYQ-SSEYE-IAPLPHVANFLNSVRYIEELQKFV 320
A+PA + R +MN +L+ + Q S Y+ + LPHV +L SVRYIEELQKFV
Sbjct: 216 AYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFV 275
Query: 321 EDDQYKLSLKLEPPSPVGSCAGSKESV 347
EDD YKLSL++EP S SKE +
Sbjct: 276 EDDNYKLSLRIEPGSSSPRLVSSKEDL 302
>AL356862-4|CAI39721.1| 384|Homo sapiens Ral GEF with PH domain and
SH3 binding motif 1 protein.
Length = 384
Score = 299 bits (733), Expect = 2e-80
Identities = 145/267 (54%), Positives = 197/267 (73%), Gaps = 8/267 (2%)
Query: 89 NQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFT 148
++S+D +V L+++P++ +Q+TL+D+P FKAI+PEEL +CGW+K K ++APNVVAFT
Sbjct: 36 SKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFT 95
Query: 149 KRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYR 208
+RFN+VSFW V+EIL Q+ K RAEI++HF+K+AKKL ELNNLHSL +V+SAL SA I+R
Sbjct: 96 RRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFR 155
Query: 209 LTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISL-PCIPYLGIFLTDLVYIDI 267
LTKTWA L++KDK F+KL L + DN+ REY++S+ + P IPYLGI+L DL+YID
Sbjct: 156 LTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDS 215
Query: 268 AHPAG-----SPHRVTKMNIVLKALERYQ-SSEYE-IAPLPHVANFLNSVRYIEELQKFV 320
A+PA + R +MN +L+ + Q S Y+ + LPHV +L SVRYIEELQKFV
Sbjct: 216 AYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFV 275
Query: 321 EDDQYKLSLKLEPPSPVGSCAGSKESV 347
EDD YKLSL++EP S SKE +
Sbjct: 276 EDDNYKLSLRIEPGSSSPRLVSSKEDL 302
>AL356862-1|CAI39718.1| 305|Homo sapiens Ral GEF with PH domain and
SH3 binding motif 1 protein.
Length = 305
Score = 299 bits (733), Expect = 2e-80
Identities = 145/267 (54%), Positives = 197/267 (73%), Gaps = 8/267 (2%)
Query: 89 NQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFT 148
++S+D +V L+++P++ +Q+TL+D+P FKAI+PEEL +CGW+K K ++APNVVAFT
Sbjct: 36 SKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFT 95
Query: 149 KRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYR 208
+RFN+VSFW V+EIL Q+ K RAEI++HF+K+AKKL ELNNLHSL +V+SAL SA I+R
Sbjct: 96 RRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFR 155
Query: 209 LTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISL-PCIPYLGIFLTDLVYIDI 267
LTKTWA L++KDK F+KL L + DN+ REY++S+ + P IPYLGI+L DL+YID
Sbjct: 156 LTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDS 215
Query: 268 AHPAG-----SPHRVTKMNIVLKALERYQ-SSEYE-IAPLPHVANFLNSVRYIEELQKFV 320
A+PA + R +MN +L+ + Q S Y+ + LPHV +L SVRYIEELQKFV
Sbjct: 216 AYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFV 275
Query: 321 EDDQYKLSLKLEPPSPVGSCAGSKESV 347
EDD YKLSL++EP S SKE +
Sbjct: 276 EDDNYKLSLRIEPGSSSPRLVSSKEDL 302
>AL160169-4|CAI40641.1| 384|Homo sapiens Ral GEF with PH domain and
SH3 binding motif 1 protein.
Length = 384
Score = 299 bits (733), Expect = 2e-80
Identities = 145/267 (54%), Positives = 197/267 (73%), Gaps = 8/267 (2%)
Query: 89 NQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFT 148
++S+D +V L+++P++ +Q+TL+D+P FKAI+PEEL +CGW+K K ++APNVVAFT
Sbjct: 36 SKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFT 95
Query: 149 KRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYR 208
+RFN+VSFW V+EIL Q+ K RAEI++HF+K+AKKL ELNNLHSL +V+SAL SA I+R
Sbjct: 96 RRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFR 155
Query: 209 LTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISL-PCIPYLGIFLTDLVYIDI 267
LTKTWA L++KDK F+KL L + DN+ REY++S+ + P IPYLGI+L DL+YID
Sbjct: 156 LTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDS 215
Query: 268 AHPAG-----SPHRVTKMNIVLKALERYQ-SSEYE-IAPLPHVANFLNSVRYIEELQKFV 320
A+PA + R +MN +L+ + Q S Y+ + LPHV +L SVRYIEELQKFV
Sbjct: 216 AYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFV 275
Query: 321 EDDQYKLSLKLEPPSPVGSCAGSKESV 347
EDD YKLSL++EP S SKE +
Sbjct: 276 EDDNYKLSLRIEPGSSSPRLVSSKEDL 302
>AL160169-1|CAI40638.1| 305|Homo sapiens Ral GEF with PH domain and
SH3 binding motif 1 protein.
Length = 305
Score = 299 bits (733), Expect = 2e-80
Identities = 145/267 (54%), Positives = 197/267 (73%), Gaps = 8/267 (2%)
Query: 89 NQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFT 148
++S+D +V L+++P++ +Q+TL+D+P FKAI+PEEL +CGW+K K ++APNVVAFT
Sbjct: 36 SKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFT 95
Query: 149 KRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYR 208
+RFN+VSFW V+EIL Q+ K RAEI++HF+K+AKKL ELNNLHSL +V+SAL SA I+R
Sbjct: 96 RRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFR 155
Query: 209 LTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISL-PCIPYLGIFLTDLVYIDI 267
LTKTWA L++KDK F+KL L + DN+ REY++S+ + P IPYLGI+L DL+YID
Sbjct: 156 LTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDS 215
Query: 268 AHPAG-----SPHRVTKMNIVLKALERYQ-SSEYE-IAPLPHVANFLNSVRYIEELQKFV 320
A+PA + R +MN +L+ + Q S Y+ + LPHV +L SVRYIEELQKFV
Sbjct: 216 AYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFV 275
Query: 321 EDDQYKLSLKLEPPSPVGSCAGSKESV 347
EDD YKLSL++EP S SKE +
Sbjct: 276 EDDNYKLSLRIEPGSSSPRLVSSKEDL 302
>AL355520-1|CAI21918.1| 279|Homo sapiens Ral GEF with PH domain and
SH3 binding motif 2 protein.
Length = 279
Score = 287 bits (705), Expect = 5e-77
Identities = 136/246 (55%), Positives = 185/246 (75%), Gaps = 7/246 (2%)
Query: 88 INQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAF 147
+ +S+D +V L+++P++ Q+TL+D+P FKAI+P+EL++CGW K K + APN VAF
Sbjct: 34 LKKSFDAVVFDVLKVTPEEYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSSAPNAVAF 93
Query: 148 TKRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIY 207
T+RFN VSFW V+EIL+ Q+ K RAE+++H+IK AKKL+ELNNLH+L AV+S L SA I+
Sbjct: 94 TRRFNHVSFWVVREILHAQTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIF 153
Query: 208 RLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISL-PCIPYLGIFLTDLVYID 266
RLTKTWA LS+KDK F+KL + + DN+ LR+Y+ S+ + PCIPYLGI+L+DL YID
Sbjct: 154 RLTKTWALLSRKDKTTFEKLEYVMSKEDNYKRLRDYISSLKMTPCIPYLGIYLSDLTYID 213
Query: 267 IAHPA-GS----PHRVTKMNIVLKAL-ERYQSSEYEIAPLPHVANFLNSVRYIEELQKFV 320
A+P+ GS R MN +L+ + + QS EY+I LPHV +LNSV+YIEELQKFV
Sbjct: 214 SAYPSTGSILENEQRSNLMNNILRIISDLQQSCEYDIPMLPHVQKYLNSVQYIEELQKFV 273
Query: 321 EDDQYK 326
EDD YK
Sbjct: 274 EDDNYK 279
>AL162255-2|CAH71096.1| 279|Homo sapiens Ral GEF with PH domain and
SH3 binding motif 2 protein.
Length = 279
Score = 287 bits (705), Expect = 5e-77
Identities = 136/246 (55%), Positives = 185/246 (75%), Gaps = 7/246 (2%)
Query: 88 INQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAF 147
+ +S+D +V L+++P++ Q+TL+D+P FKAI+P+EL++CGW K K + APN VAF
Sbjct: 34 LKKSFDAVVFDVLKVTPEEYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSSAPNAVAF 93
Query: 148 TKRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIY 207
T+RFN VSFW V+EIL+ Q+ K RAE+++H+IK AKKL+ELNNLH+L AV+S L SA I+
Sbjct: 94 TRRFNHVSFWVVREILHAQTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIF 153
Query: 208 RLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISL-PCIPYLGIFLTDLVYID 266
RLTKTWA LS+KDK F+KL + + DN+ LR+Y+ S+ + PCIPYLGI+L+DL YID
Sbjct: 154 RLTKTWALLSRKDKTTFEKLEYVMSKEDNYKRLRDYISSLKMTPCIPYLGIYLSDLTYID 213
Query: 267 IAHPA-GS----PHRVTKMNIVLKAL-ERYQSSEYEIAPLPHVANFLNSVRYIEELQKFV 320
A+P+ GS R MN +L+ + + QS EY+I LPHV +LNSV+YIEELQKFV
Sbjct: 214 SAYPSTGSILENEQRSNLMNNILRIISDLQQSCEYDIPMLPHVQKYLNSVQYIEELQKFV 273
Query: 321 EDDQYK 326
EDD YK
Sbjct: 274 EDDNYK 279
>AK001106-1|BAA91506.1| 279|Homo sapiens protein ( Homo sapiens
cDNA FLJ10244 fis, clone HEMBB1000632, weakly similar to
GUANINE NUCLEOTIDE RELEASING PROTEIN. ).
Length = 279
Score = 287 bits (705), Expect = 5e-77
Identities = 136/246 (55%), Positives = 185/246 (75%), Gaps = 7/246 (2%)
Query: 88 INQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAF 147
+ +S+D +V L+++P++ Q+TL+D+P FKAI+P+EL++CGW K K + APN VAF
Sbjct: 34 LKKSFDAVVFDVLKVTPEEYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSSAPNAVAF 93
Query: 148 TKRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIY 207
T+RFN VSFW V+EIL+ Q+ K RAE+++H+IK AKKL+ELNNLH+L AV+S L SA I+
Sbjct: 94 TRRFNHVSFWVVREILHAQTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIF 153
Query: 208 RLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISL-PCIPYLGIFLTDLVYID 266
RLTKTWA LS+KDK F+KL + + DN+ LR+Y+ S+ + PCIPYLGI+L+DL YID
Sbjct: 154 RLTKTWALLSRKDKTTFEKLEYVMSKEDNYKRLRDYISSLKMTPCIPYLGIYLSDLTYID 213
Query: 267 IAHPA-GS----PHRVTKMNIVLKAL-ERYQSSEYEIAPLPHVANFLNSVRYIEELQKFV 320
A+P+ GS R MN +L+ + + QS EY+I LPHV +LNSV+YIEELQKFV
Sbjct: 214 SAYPSTGSILENEQRSNLMNNILRIISDLQQSCEYDIPMLPHVQKYLNSVQYIEELQKFV 273
Query: 321 EDDQYK 326
EDD YK
Sbjct: 274 EDDNYK 279
>AL356862-6|CAI39723.1| 213|Homo sapiens Ral GEF with PH domain and
SH3 binding motif 1 protein.
Length = 213
Score = 219 bits (534), Expect = 3e-56
Identities = 99/177 (55%), Positives = 139/177 (78%), Gaps = 1/177 (0%)
Query: 89 NQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFT 148
++S+D +V L+++P++ +Q+TL+D+P FKAI+PEEL +CGW+K K ++APNVVAFT
Sbjct: 36 SKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFT 95
Query: 149 KRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYR 208
+RFN+VSFW V+EIL Q+ K RAEI++HF+K+AKKL ELNNLHSL +V+SAL SA I+R
Sbjct: 96 RRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFR 155
Query: 209 LTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISL-PCIPYLGIFLTDLVY 264
LTKTWA L++KDK F+KL L + DN+ REY++S+ + P IPYLG L L++
Sbjct: 156 LTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGRSLNWLIF 212
>AL160169-6|CAI40643.1| 213|Homo sapiens Ral GEF with PH domain and
SH3 binding motif 1 protein.
Length = 213
Score = 219 bits (534), Expect = 3e-56
Identities = 99/177 (55%), Positives = 139/177 (78%), Gaps = 1/177 (0%)
Query: 89 NQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFT 148
++S+D +V L+++P++ +Q+TL+D+P FKAI+PEEL +CGW+K K ++APNVVAFT
Sbjct: 36 SKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFT 95
Query: 149 KRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYR 208
+RFN+VSFW V+EIL Q+ K RAEI++HF+K+AKKL ELNNLHSL +V+SAL SA I+R
Sbjct: 96 RRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFR 155
Query: 209 LTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISL-PCIPYLGIFLTDLVY 264
LTKTWA L++KDK F+KL L + DN+ REY++S+ + P IPYLG L L++
Sbjct: 156 LTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGRSLNWLIF 212
>BC126112-1|AAI26113.1| 1237|Homo sapiens Ras protein-specific guanine
nucleotide-releasing factor 2 protein.
Length = 1237
Score = 133 bits (322), Expect = 1e-30
Identities = 81/241 (33%), Positives = 130/241 (53%), Gaps = 11/241 (4%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQE 161
LS ++ Q+TLLD F++I EE GW KL+K P ++ ++ FN +S +
Sbjct: 1001 LSAMELAEQITLLDHVIFRSIPYEEFLGQGWMKLDKNERTPYIMKTSQHFNDMSNLVASQ 1060
Query: 162 ILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDK 221
I+N +RA + ++ VA L+N + + + SAL+ ++IYRL KTWA +SK+ K
Sbjct: 1061 IMNYADVSSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTK 1120
Query: 222 QQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPH---RVT 278
DKL + + LRE LK+ + P +PYLG++LTDL +I+ P + +
Sbjct: 1121 ALMDKLQKTVSSEGRFKNLRETLKNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGLVNFS 1180
Query: 279 KMNI---VLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEPPS 335
KM + +++ + ++Q + Y I P VA +L I + ED Y+LSLK+EP
Sbjct: 1181 KMRMISHIIREIRQFQQTSYRIDHQPKVAQYLLDKDLIID-----EDTLYELSLKIEPRL 1235
Query: 336 P 336
P
Sbjct: 1236 P 1236
>AF181250-1|AAD55268.1| 1237|Homo sapiens Ras guanine nucleotide
exchange factor 2 protein.
Length = 1237
Score = 133 bits (322), Expect = 1e-30
Identities = 81/241 (33%), Positives = 130/241 (53%), Gaps = 11/241 (4%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQE 161
LS ++ Q+TLLD F++I EE GW KL+K P ++ ++ FN +S +
Sbjct: 1001 LSAMELAEQITLLDHVIFRSIPYEEFLGQGWMKLDKNERTPYIMKTSQHFNDMSNLVASQ 1060
Query: 162 ILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDK 221
I+N +RA + ++ VA L+N + + + SAL+ ++IYRL KTWA +SK+ K
Sbjct: 1061 IMNYADVSSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTK 1120
Query: 222 QQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPH---RVT 278
DKL + + LRE LK+ + P +PYLG++LTDL +I+ P + +
Sbjct: 1121 ALMDKLQKTVSSEGRFKNLRETLKNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGLVNFS 1180
Query: 279 KMNI---VLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEPPS 335
KM + +++ + ++Q + Y I P VA +L I + ED Y+LSLK+EP
Sbjct: 1181 KMRMISHIIREIRQFQQTSYRIDHQPKVAQYLLDKDLIID-----EDTLYELSLKIEPRL 1235
Query: 336 P 336
P
Sbjct: 1236 P 1236
>AF023130-1|AAB80953.1| 1237|Homo sapiens Ras-GRF2 protein.
Length = 1237
Score = 133 bits (322), Expect = 1e-30
Identities = 81/241 (33%), Positives = 130/241 (53%), Gaps = 11/241 (4%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQE 161
LS ++ Q+TLLD F++I EE GW KL+K P ++ ++ FN +S +
Sbjct: 1001 LSAMELAEQITLLDHVIFRSIPYEEFLGQGWMKLDKNERTPYIMKTSQHFNDMSNLVASQ 1060
Query: 162 ILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDK 221
I+N +RA + ++ VA L+N + + + SAL+ ++IYRL KTWA +SK+ K
Sbjct: 1061 IMNYADVSSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTK 1120
Query: 222 QQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPH---RVT 278
DKL + + LRE LK+ + P +PYLG++LTDL +I+ P + +
Sbjct: 1121 ALMDKLQKTVSSEGRFKNLRETLKNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGLVNFS 1180
Query: 279 KMNI---VLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEPPS 335
KM + +++ + ++Q + Y I P VA +L I + ED Y+LSLK+EP
Sbjct: 1181 KMRMISHIIREIRQFQQTSYRIDHQPKVAQYLLDKDLIID-----EDTLYELSLKIEPRL 1235
Query: 336 P 336
P
Sbjct: 1236 P 1236
>S62035-1|AAB26881.1| 489|Homo sapiens Ras-specific guanine
nucleotide-releasing factor protein.
Length = 489
Score = 129 bits (312), Expect = 2e-29
Identities = 75/237 (31%), Positives = 125/237 (52%), Gaps = 11/237 (4%)
Query: 106 DVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNG 165
++ QLTLLD FK I EE GW KL K P ++ TK FN +S EI+
Sbjct: 257 EIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEIIRN 316
Query: 166 QSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFD 225
+ AR + ++ VA L+N +++ + S+++ ++I+RL KTW +SK+ K D
Sbjct: 317 EDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALID 376
Query: 226 KLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPH---RVTKMNI 282
KL +L + LRE LK+ PC+PYLG++LTDL +I+ P + +KM +
Sbjct: 377 KLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMRM 436
Query: 283 ---VLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEPPSP 336
+++ + ++Q + Y+I V +L ++ + E+ Y+ SL++EP P
Sbjct: 437 ISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMD-----EESLYESSLRIEPKLP 488
>L26584-1|AAA58417.1| 1275|Homo sapiens CDC25 protein.
Length = 1275
Score = 129 bits (312), Expect = 2e-29
Identities = 75/237 (31%), Positives = 125/237 (52%), Gaps = 11/237 (4%)
Query: 106 DVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNG 165
++ QLTLLD FK I EE GW KL K P ++ TK FN +S EI+
Sbjct: 1043 EIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEIIRN 1102
Query: 166 QSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFD 225
+ AR + ++ VA L+N +++ + S+++ ++I+RL KTW +SK+ K D
Sbjct: 1103 EDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALID 1162
Query: 226 KLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPH---RVTKMNI 282
KL +L + LRE LK+ PC+PYLG++LTDL +I+ P + +KM +
Sbjct: 1163 KLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMRM 1222
Query: 283 ---VLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEPPSP 336
+++ + ++Q + Y+I V +L ++ + E+ Y+ SL++EP P
Sbjct: 1223 ISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMD-----EESLYESSLRIEPKLP 1274
>AL356862-5|CAI39722.1| 173|Homo sapiens Ral GEF with PH domain and
SH3 binding motif 1 protein.
Length = 173
Score = 129 bits (312), Expect = 2e-29
Identities = 73/168 (43%), Positives = 109/168 (64%), Gaps = 31/168 (18%)
Query: 89 NQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFT 148
++S+D +V L+++P++ +Q+TL+D+P FKAI+PEEL +CGW+K K ++APNVVAFT
Sbjct: 36 SKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFT 95
Query: 149 KRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYR 208
+RFN Q++L +L+ L++L S V+SAL SA I+R
Sbjct: 96 RRFN-------QKLL--------------------ELNNLHSLMS---VVSALQSAPIFR 125
Query: 209 LTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISL-PCIPYL 255
LTKTWA L++KDK F+KL L + DN+ REY++S+ + P IPYL
Sbjct: 126 LTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYL 173
>AL160169-5|CAI40642.1| 173|Homo sapiens Ral GEF with PH domain and
SH3 binding motif 1 protein.
Length = 173
Score = 129 bits (312), Expect = 2e-29
Identities = 73/168 (43%), Positives = 109/168 (64%), Gaps = 31/168 (18%)
Query: 89 NQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFT 148
++S+D +V L+++P++ +Q+TL+D+P FKAI+PEEL +CGW+K K ++APNVVAFT
Sbjct: 36 SKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFT 95
Query: 149 KRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYR 208
+RFN Q++L +L+ L++L S V+SAL SA I+R
Sbjct: 96 RRFN-------QKLL--------------------ELNNLHSLMS---VVSALQSAPIFR 125
Query: 209 LTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISL-PCIPYL 255
LTKTWA L++KDK F+KL L + DN+ REY++S+ + P IPYL
Sbjct: 126 LTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYL 173
>AL450263-1|CAI41454.1| 152|Homo sapiens Ral GEF with PH domain and
SH3 binding motif 1 protein.
Length = 152
Score = 118 bits (283), Expect = 7e-26
Identities = 56/123 (45%), Positives = 81/123 (65%), Gaps = 1/123 (0%)
Query: 455 QGCVKRKTILKEGRKISLSSWQRYWLQMSGNMLFFYGAKSFKGTNRSDFRSERCKVLTLV 514
+G ++RKT+LKEGRK +LSSW RYW+ +SG+ L +YGAKS +GT+R ++S K +++V
Sbjct: 30 EGPLRRKTLLKEGRKPALSSWTRYWVILSGSTLLYYGAKSLRGTDRKHYKSTPGKKVSIV 89
Query: 515 GW-IAVWADGDAADAFQLINHHSGTVYKFKAGSEYAAKQWIAKIEEVTNKIVKPLPANLM 573
GW + + D + D FQL N G VYKF+ GS + A W +++ +PANLM
Sbjct: 90 GWMVQLPDDPEHPDIFQLNNPDKGNVYKFQTGSRFHAILWHKHLDDACKSNRPQVPANLM 149
Query: 574 SFE 576
SFE
Sbjct: 150 SFE 152
>D21239-1|BAA04770.1| 1077|Homo sapiens C3G protein protein.
Length = 1077
Score = 111 bits (268), Expect = 5e-24
Identities = 72/234 (30%), Positives = 118/234 (50%), Gaps = 19/234 (8%)
Query: 106 DVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNG 165
++ QLTLLD F I+ E+ W K +PN+ FT+ FN +S+W I+
Sbjct: 843 EIAEQLTLLDAELFYKIEIPEVLL--WAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQ 900
Query: 166 QSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFD 225
+ + R ++ FIK+ K L +LNN +S A++SAL SA I RL W K+ +
Sbjct: 901 EKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRL--EW---QKQTSEGLA 955
Query: 226 KLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHP------AGSPHRVTK 279
+ L + ++ A R L + PCIPYLG+ L DL ++ + +P R +
Sbjct: 956 EYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRWQQ 1015
Query: 280 MNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEP 333
NI L ++ +Q + Y++ + NF N + + L E+ ++LSLK++P
Sbjct: 1016 FNI-LDSMRCFQQAHYDMRRNDDIINFFND--FSDHL---AEEALWELSLKIKP 1063
>BC041710-1|AAH41710.1| 1095|Homo sapiens Rap guanine nucleotide
exchange factor (GEF) 1 protein.
Length = 1095
Score = 111 bits (268), Expect = 5e-24
Identities = 72/234 (30%), Positives = 118/234 (50%), Gaps = 19/234 (8%)
Query: 106 DVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNG 165
++ QLTLLD F I+ E+ W K +PN+ FT+ FN +S+W I+
Sbjct: 861 EIAEQLTLLDAELFYKIEIPEVLL--WAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQ 918
Query: 166 QSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFD 225
+ + R ++ FIK+ K L +LNN +S A++SAL SA I RL W K+ +
Sbjct: 919 EKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRL--EW---QKQTSEGLA 973
Query: 226 KLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHP------AGSPHRVTK 279
+ L + ++ A R L + PCIPYLG+ L DL ++ + +P R +
Sbjct: 974 EYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRWQQ 1033
Query: 280 MNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEP 333
NI L ++ +Q + Y++ + NF N + + L E+ ++LSLK++P
Sbjct: 1034 FNI-LDSMRCFQQAHYDMRRNDDIINFFND--FSDHL---AEEALWELSLKIKP 1081
>AL160276-7|CAI40651.1| 1023|Homo sapiens Rap guanine nucleotide
exchange factor (GEF) 1 protein.
Length = 1023
Score = 111 bits (268), Expect = 5e-24
Identities = 72/234 (30%), Positives = 118/234 (50%), Gaps = 19/234 (8%)
Query: 106 DVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNG 165
++ QLTLLD F I+ E+ W K +PN+ FT+ FN +S+W I+
Sbjct: 789 EIAEQLTLLDAELFYKIEIPEVLL--WAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQ 846
Query: 166 QSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFD 225
+ + R ++ FIK+ K L +LNN +S A++SAL SA I RL W K+ +
Sbjct: 847 EKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRL--EW---QKQTSEGLA 901
Query: 226 KLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHP------AGSPHRVTK 279
+ L + ++ A R L + PCIPYLG+ L DL ++ + +P R +
Sbjct: 902 EYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRWQQ 961
Query: 280 MNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEP 333
NI L ++ +Q + Y++ + NF N + + L E+ ++LSLK++P
Sbjct: 962 FNI-LDSMRCFQQAHYDMRRNDDIINFFND--FSDHL---AEEALWELSLKIKP 1009
>AL160276-3|CAI40647.1| 1094|Homo sapiens Rap guanine nucleotide
exchange factor (GEF) 1 protein.
Length = 1094
Score = 111 bits (268), Expect = 5e-24
Identities = 72/234 (30%), Positives = 118/234 (50%), Gaps = 19/234 (8%)
Query: 106 DVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNG 165
++ QLTLLD F I+ E+ W K +PN+ FT+ FN +S+W I+
Sbjct: 860 EIAEQLTLLDAELFYKIEIPEVLL--WAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQ 917
Query: 166 QSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFD 225
+ + R ++ FIK+ K L +LNN +S A++SAL SA I RL W K+ +
Sbjct: 918 EKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRL--EW---QKQTSEGLA 972
Query: 226 KLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHP------AGSPHRVTK 279
+ L + ++ A R L + PCIPYLG+ L DL ++ + +P R +
Sbjct: 973 EYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRWQQ 1032
Query: 280 MNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEP 333
NI L ++ +Q + Y++ + NF N + + L E+ ++LSLK++P
Sbjct: 1033 FNI-LDSMRCFQQAHYDMRRNDDIINFFND--FSDHL---AEEALWELSLKIKP 1080
>AL160276-2|CAI40646.1| 1077|Homo sapiens Rap guanine nucleotide
exchange factor (GEF) 1 protein.
Length = 1077
Score = 111 bits (268), Expect = 5e-24
Identities = 72/234 (30%), Positives = 118/234 (50%), Gaps = 19/234 (8%)
Query: 106 DVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNG 165
++ QLTLLD F I+ E+ W K +PN+ FT+ FN +S+W I+
Sbjct: 843 EIAEQLTLLDAELFYKIEIPEVLL--WAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQ 900
Query: 166 QSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFD 225
+ + R ++ FIK+ K L +LNN +S A++SAL SA I RL W K+ +
Sbjct: 901 EKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRL--EW---QKQTSEGLA 955
Query: 226 KLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHP------AGSPHRVTK 279
+ L + ++ A R L + PCIPYLG+ L DL ++ + +P R +
Sbjct: 956 EYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRWQQ 1015
Query: 280 MNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEP 333
NI L ++ +Q + Y++ + NF N + + L E+ ++LSLK++P
Sbjct: 1016 FNI-LDSMRCFQQAHYDMRRNDDIINFFND--FSDHL---AEEALWELSLKIKP 1063
>AL160271-3|CAI13383.1| 1094|Homo sapiens Rap guanine nucleotide
exchange factor (GEF) 1 protein.
Length = 1094
Score = 111 bits (268), Expect = 5e-24
Identities = 72/234 (30%), Positives = 118/234 (50%), Gaps = 19/234 (8%)
Query: 106 DVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNG 165
++ QLTLLD F I+ E+ W K +PN+ FT+ FN +S+W I+
Sbjct: 860 EIAEQLTLLDAELFYKIEIPEVLL--WAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQ 917
Query: 166 QSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFD 225
+ + R ++ FIK+ K L +LNN +S A++SAL SA I RL W K+ +
Sbjct: 918 EKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRL--EW---QKQTSEGLA 972
Query: 226 KLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHP------AGSPHRVTK 279
+ L + ++ A R L + PCIPYLG+ L DL ++ + +P R +
Sbjct: 973 EYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRWQQ 1032
Query: 280 MNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEP 333
NI L ++ +Q + Y++ + NF N + + L E+ ++LSLK++P
Sbjct: 1033 FNI-LDSMRCFQQAHYDMRRNDDIINFFND--FSDHL---AEEALWELSLKIKP 1080
>AL160271-2|CAI13382.1| 1077|Homo sapiens Rap guanine nucleotide
exchange factor (GEF) 1 protein.
Length = 1077
Score = 111 bits (268), Expect = 5e-24
Identities = 72/234 (30%), Positives = 118/234 (50%), Gaps = 19/234 (8%)
Query: 106 DVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNG 165
++ QLTLLD F I+ E+ W K +PN+ FT+ FN +S+W I+
Sbjct: 843 EIAEQLTLLDAELFYKIEIPEVLL--WAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQ 900
Query: 166 QSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFD 225
+ + R ++ FIK+ K L +LNN +S A++SAL SA I RL W K+ +
Sbjct: 901 EKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRL--EW---QKQTSEGLA 955
Query: 226 KLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHP------AGSPHRVTK 279
+ L + ++ A R L + PCIPYLG+ L DL ++ + +P R +
Sbjct: 956 EYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRWQQ 1015
Query: 280 MNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEP 333
NI L ++ +Q + Y++ + NF N + + L E+ ++LSLK++P
Sbjct: 1016 FNI-LDSMRCFQQAHYDMRRNDDIINFFND--FSDHL---AEEALWELSLKIKP 1063
>L13857-1|AAA35913.1| 1333|Homo sapiens guanine nucleotide exchange
factor protein.
Length = 1333
Score = 108 bits (260), Expect = 5e-23
Identities = 62/247 (25%), Positives = 130/247 (52%), Gaps = 12/247 (4%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTV 159
L L P ++ QLTLL+ ++A++P EL WTK +K +PN++ + ++ W
Sbjct: 777 LTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFE 836
Query: 160 QEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKK 219
+ I+ ++ + R +++ I++ + ELNN + + V+SA++S+ +YRL T+ + +
Sbjct: 837 KCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSR 896
Query: 220 DKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPA-----GSP 274
K+ ++ EL D++ L+SI+ PC+P+ GI+LT+++ + +P G
Sbjct: 897 QKKILEEAHEL--SEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKE 954
Query: 275 ----HRVTKMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYI-EELQKFVEDDQYKLSL 329
+ K+ + +++YQ+ Y + + F ++ + ++K D + SL
Sbjct: 955 LINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSL 1014
Query: 330 KLEPPSP 336
++EP +P
Sbjct: 1015 EIEPRNP 1021
>AF441482-1|AAM22406.1| 1105|Homo sapiens alternate SOS1 protein.
Length = 1105
Score = 108 bits (260), Expect = 5e-23
Identities = 62/247 (25%), Positives = 130/247 (52%), Gaps = 12/247 (4%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTV 159
L L P ++ QLTLL+ ++A++P EL WTK +K +PN++ + ++ W
Sbjct: 777 LTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFE 836
Query: 160 QEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKK 219
+ I+ ++ + R +++ I++ + ELNN + + V+SA++S+ +YRL T+ + +
Sbjct: 837 KCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSR 896
Query: 220 DKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPA-----GSP 274
K+ ++ EL D++ L+SI+ PC+P+ GI+LT+++ + +P G
Sbjct: 897 QKKILEEAHEL--SEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKE 954
Query: 275 ----HRVTKMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYI-EELQKFVEDDQYKLSL 329
+ K+ + +++YQ+ Y + + F ++ + ++K D + SL
Sbjct: 955 LINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSL 1014
Query: 330 KLEPPSP 336
++EP +P
Sbjct: 1015 EIEPRNP 1021
>AC019171-1|AAX93186.1| 1304|Homo sapiens unknown protein.
Length = 1304
Score = 108 bits (260), Expect = 5e-23
Identities = 62/247 (25%), Positives = 130/247 (52%), Gaps = 12/247 (4%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTV 159
L L P ++ QLTLL+ ++A++P EL WTK +K +PN++ + ++ W
Sbjct: 748 LTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFE 807
Query: 160 QEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKK 219
+ I+ ++ + R +++ I++ + ELNN + + V+SA++S+ +YRL T+ + +
Sbjct: 808 KCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSR 867
Query: 220 DKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPA-----GSP 274
K+ ++ EL D++ L+SI+ PC+P+ GI+LT+++ + +P G
Sbjct: 868 QKKILEEAHEL--SEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKE 925
Query: 275 ----HRVTKMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYI-EELQKFVEDDQYKLSL 329
+ K+ + +++YQ+ Y + + F ++ + ++K D + SL
Sbjct: 926 LINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSL 985
Query: 330 KLEPPSP 336
++EP +P
Sbjct: 986 EIEPRNP 992
>AB209140-1|BAD92377.1| 988|Homo sapiens son of sevenless homolog 1
variant protein.
Length = 988
Score = 108 bits (260), Expect = 5e-23
Identities = 62/247 (25%), Positives = 130/247 (52%), Gaps = 12/247 (4%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTV 159
L L P ++ QLTLL+ ++A++P EL WTK +K +PN++ + ++ W
Sbjct: 447 LTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFE 506
Query: 160 QEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKK 219
+ I+ ++ + R +++ I++ + ELNN + + V+SA++S+ +YRL T+ + +
Sbjct: 507 KCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSR 566
Query: 220 DKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPA-----GSP 274
K+ ++ EL D++ L+SI+ PC+P+ GI+LT+++ + +P G
Sbjct: 567 QKKILEEAHEL--SEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKE 624
Query: 275 ----HRVTKMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYI-EELQKFVEDDQYKLSL 329
+ K+ + +++YQ+ Y + + F ++ + ++K D + SL
Sbjct: 625 LINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSL 684
Query: 330 KLEPPSP 336
++EP +P
Sbjct: 685 EIEPRNP 691
>AL355520-9|CAI21925.1| 150|Homo sapiens Ral GEF with PH domain and
SH3 binding motif 2 protein.
Length = 150
Score = 107 bits (256), Expect = 1e-22
Identities = 48/123 (39%), Positives = 73/123 (59%), Gaps = 1/123 (0%)
Query: 455 QGCVKRKTILKEGRKISLSSWQRYWLQMSGNMLFFYGAKSFKGTNRSDFRSERCKVLTLV 514
QG ++RKT+LKEG+K +++SW +YW + G LF+Y AKS K T R F+S K ++++
Sbjct: 28 QGVLRRKTLLKEGKKPTVASWTKYWAALCGTQLFYYAAKSLKATERKHFKSTSNKNVSVI 87
Query: 515 GWIAVWADG-DAADAFQLINHHSGTVYKFKAGSEYAAKQWIAKIEEVTNKIVKPLPANLM 573
GW+ + AD + D F L + G YKF+AG+ A W + + +P NLM
Sbjct: 88 GWMVMMADDPEHPDLFLLTDSEKGNSYKFQAGNRMNAMLWFKHLSAACQSNKQQVPTNLM 147
Query: 574 SFE 576
+FE
Sbjct: 148 TFE 150
>AK098470-1|BAC05311.1| 232|Homo sapiens protein ( Homo sapiens
cDNA FLJ25604 fis, clone JTH14207. ).
Length = 232
Score = 107 bits (256), Expect = 1e-22
Identities = 48/123 (39%), Positives = 73/123 (59%), Gaps = 1/123 (0%)
Query: 455 QGCVKRKTILKEGRKISLSSWQRYWLQMSGNMLFFYGAKSFKGTNRSDFRSERCKVLTLV 514
QG ++RKT+LKEG+K +++SW +YW + G LF+Y AKS K T R F+S K ++++
Sbjct: 110 QGVLRRKTLLKEGKKPTVASWTKYWAALCGTQLFYYAAKSLKATERKHFKSTSNKNVSVI 169
Query: 515 GWIAVWADG-DAADAFQLINHHSGTVYKFKAGSEYAAKQWIAKIEEVTNKIVKPLPANLM 573
GW+ + AD + D F L + G YKF+AG+ A W + + +P NLM
Sbjct: 170 GWMVMMADDPEHPDLFLLTDSEKGNSYKFQAGNRMNAMLWFKHLSAACQSNKQQVPTNLM 229
Query: 574 SFE 576
+FE
Sbjct: 230 TFE 232
>L20686-1|AAA91852.1| 572|Homo sapiens guanine nucleotide releasing
factor protein.
Length = 572
Score = 106 bits (255), Expect = 2e-22
Identities = 61/244 (25%), Positives = 126/244 (51%), Gaps = 12/244 (4%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTV 159
+ L P ++ QLTLL+ ++ ++P EL WTK +K +PN++ + ++ W
Sbjct: 52 MTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFE 111
Query: 160 QEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKK 219
+ I+ ++ + R +++ I++ + +LNN + + ++SA++S S+YRL T+ L ++
Sbjct: 112 KCIVEAENFEERVAVLSRIIEILQVFRDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQER 171
Query: 220 DKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYI-----DIAHPAGSP 274
++ D+ EL D++ LKSI+ PC+P+ GI+LT+++ D G
Sbjct: 172 KRKILDEAVEL--SQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKD 229
Query: 275 ----HRVTKMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYI-EELQKFVEDDQYKLSL 329
+ K+ + +++YQ+ Y + P + F ++ + +K D + SL
Sbjct: 230 LINFSKRRKVAEITGEIQQYQNQPYCLRIEPDMRRFFENLNPMGSACEKEFTDYLFNKSL 289
Query: 330 KLEP 333
++EP
Sbjct: 290 EIEP 293
>L13858-1|AAA35914.1| 1332|Homo sapiens guanine nucleotide exchange
factor protein.
Length = 1332
Score = 106 bits (254), Expect = 2e-22
Identities = 61/244 (25%), Positives = 126/244 (51%), Gaps = 12/244 (4%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTV 159
+ L P ++ QLTLL+ ++ ++P EL WTK +K +PN++ + ++ W
Sbjct: 775 MTLDPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFE 834
Query: 160 QEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKK 219
+ I+ ++ + R +++ I++ + +LNN + + ++SA++S S+YRL T+ L ++
Sbjct: 835 KCIVEAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQER 894
Query: 220 DKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYI-----DIAHPAGSP 274
++ D+ EL D++ LKSI+ PC+P+ GI+LT+++ D G
Sbjct: 895 KRKILDEAVEL--SQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKRKGKD 952
Query: 275 ----HRVTKMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYI-EELQKFVEDDQYKLSL 329
+ K+ + +++YQ+ Y + P + F ++ + +K D + SL
Sbjct: 953 LINFSKRRKVAEITGEIQQYQNQPYCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSL 1012
Query: 330 KLEP 333
++EP
Sbjct: 1013 EIEP 1016
>BC117261-1|AAI17262.1| 1332|Homo sapiens son of sevenless homolog 2
(Drosophila) protein.
Length = 1332
Score = 106 bits (254), Expect = 2e-22
Identities = 61/244 (25%), Positives = 126/244 (51%), Gaps = 12/244 (4%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTV 159
+ L P ++ QLTLL+ ++ ++P EL WTK +K +PN++ + ++ W
Sbjct: 775 MTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFE 834
Query: 160 QEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKK 219
+ I+ ++ + R +++ I++ + +LNN + + ++SA++S S+YRL T+ L ++
Sbjct: 835 KCIVEAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQER 894
Query: 220 DKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYI-----DIAHPAGSP 274
++ D+ EL D++ LKSI+ PC+P+ GI+LT+++ D G
Sbjct: 895 KRKILDEAVEL--SQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKD 952
Query: 275 ----HRVTKMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYI-EELQKFVEDDQYKLSL 329
+ K+ + +++YQ+ Y + P + F ++ + +K D + SL
Sbjct: 953 LINFSKRRKVAEITGEIQQYQNQPYCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSL 1012
Query: 330 KLEP 333
++EP
Sbjct: 1013 EIEP 1016
>AB209277-1|BAD92514.1| 1231|Homo sapiens son of sevenless homolog 2
variant protein.
Length = 1231
Score = 106 bits (254), Expect = 2e-22
Identities = 61/244 (25%), Positives = 126/244 (51%), Gaps = 12/244 (4%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTV 159
+ L P ++ QLTLL+ ++ ++P EL WTK +K +PN++ + ++ W
Sbjct: 805 MTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFE 864
Query: 160 QEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKK 219
+ I+ ++ + R +++ I++ + +LNN + + ++SA++S S+YRL T+ L ++
Sbjct: 865 KCIVEAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQER 924
Query: 220 DKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYI-----DIAHPAGSP 274
++ D+ EL D++ LKSI+ PC+P+ GI+LT+++ D G
Sbjct: 925 KRKILDEAVEL--SQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKD 982
Query: 275 ----HRVTKMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYI-EELQKFVEDDQYKLSL 329
+ K+ + +++YQ+ Y + P + F ++ + +K D + SL
Sbjct: 983 LINFSKRRKVAEITGEIQQYQNQPYCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSL 1042
Query: 330 KLEP 333
++EP
Sbjct: 1043 EIEP 1046
>BC059362-1|AAH59362.1| 902|Homo sapiens RALGDS protein protein.
Length = 902
Score = 105 bits (251), Expect = 6e-22
Identities = 88/273 (32%), Positives = 129/273 (47%), Gaps = 43/273 (15%)
Query: 104 PDDVGNQLTLLDLPCFKAIKPEELTTCGWT---KLNKLTVAPNVVAFTKRFNRVSFWTVQ 160
PD V Q TL+D FK + P W+ K K +AP + A +FN V+ +
Sbjct: 375 PDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQFNSVANCVIT 434
Query: 161 EILNGQSPKA--RAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSK 218
L +S KA RA ++ H+I+VA++ L N SL+A++SAL S SI+RL KTW +S+
Sbjct: 435 TCLGNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKTWEDVSR 494
Query: 219 KDKQQFDKLAELFGETDNWTALREYL------------------------KSISLPCIPY 254
+ F KL+E+F + +N++ RE L I +PY
Sbjct: 495 DSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPKRAQKRPKETGIIQGTVPY 554
Query: 255 LGIFLTDLVYIDIAHPAGSPHRV------TKMNIVLKALERYQS--SEYEIAPLPHVANF 306
LG FLTDLV +D A R+ K V+ ++ QS + Y IAP +
Sbjct: 555 LGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNYSIAPDEQFGAW 614
Query: 307 LNSVRYIEELQKFVEDDQYKLSLKLEPPSPVGS 339
+V ++ E + Y LS +LEPPS S
Sbjct: 615 FRAV------ERLSETESYNLSCELEPPSESAS 641
>AL162417-12|CAI13417.1| 859|Homo sapiens ral guanine nucleotide
dissociation stimulator protein.
Length = 859
Score = 105 bits (251), Expect = 6e-22
Identities = 88/273 (32%), Positives = 129/273 (47%), Gaps = 43/273 (15%)
Query: 104 PDDVGNQLTLLDLPCFKAIKPEELTTCGWT---KLNKLTVAPNVVAFTKRFNRVSFWTVQ 160
PD V Q TL+D FK + P W+ K K +AP + A +FN V+ +
Sbjct: 332 PDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQFNSVANCVIT 391
Query: 161 EILNGQSPKA--RAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSK 218
L +S KA RA ++ H+I+VA++ L N SL+A++SAL S SI+RL KTW +S+
Sbjct: 392 TCLGNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKTWEDVSR 451
Query: 219 KDKQQFDKLAELFGETDNWTALREYL------------------------KSISLPCIPY 254
+ F KL+E+F + +N++ RE L I +PY
Sbjct: 452 DSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPKRAQKRPKETGIIQGTVPY 511
Query: 255 LGIFLTDLVYIDIAHPAGSPHRV------TKMNIVLKALERYQS--SEYEIAPLPHVANF 306
LG FLTDLV +D A R+ K V+ ++ QS + Y IAP +
Sbjct: 512 LGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNYSIAPDEQFGAW 571
Query: 307 LNSVRYIEELQKFVEDDQYKLSLKLEPPSPVGS 339
+V ++ E + Y LS +LEPPS S
Sbjct: 572 FRAV------ERLSETESYNLSCELEPPSESAS 598
>AL162417-11|CAI13415.1| 914|Homo sapiens ral guanine nucleotide
dissociation stimulator protein.
Length = 914
Score = 105 bits (251), Expect = 6e-22
Identities = 88/273 (32%), Positives = 129/273 (47%), Gaps = 43/273 (15%)
Query: 104 PDDVGNQLTLLDLPCFKAIKPEELTTCGWT---KLNKLTVAPNVVAFTKRFNRVSFWTVQ 160
PD V Q TL+D FK + P W+ K K +AP + A +FN V+ +
Sbjct: 387 PDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQFNSVANCVIT 446
Query: 161 EILNGQSPKA--RAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSK 218
L +S KA RA ++ H+I+VA++ L N SL+A++SAL S SI+RL KTW +S+
Sbjct: 447 TCLGNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKTWEDVSR 506
Query: 219 KDKQQFDKLAELFGETDNWTALREYL------------------------KSISLPCIPY 254
+ F KL+E+F + +N++ RE L I +PY
Sbjct: 507 DSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPKRAQKRPKETGIIQGTVPY 566
Query: 255 LGIFLTDLVYIDIAHPAGSPHRV------TKMNIVLKALERYQS--SEYEIAPLPHVANF 306
LG FLTDLV +D A R+ K V+ ++ QS + Y IAP +
Sbjct: 567 LGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNYSIAPDEQFGAW 626
Query: 307 LNSVRYIEELQKFVEDDQYKLSLKLEPPSPVGS 339
+V ++ E + Y LS +LEPPS S
Sbjct: 627 FRAV------ERLSETESYNLSCELEPPSESAS 653
>AL162417-10|CAI13416.1| 902|Homo sapiens ral guanine nucleotide
dissociation stimulator protein.
Length = 902
Score = 105 bits (251), Expect = 6e-22
Identities = 88/273 (32%), Positives = 129/273 (47%), Gaps = 43/273 (15%)
Query: 104 PDDVGNQLTLLDLPCFKAIKPEELTTCGWT---KLNKLTVAPNVVAFTKRFNRVSFWTVQ 160
PD V Q TL+D FK + P W+ K K +AP + A +FN V+ +
Sbjct: 375 PDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQFNSVANCVIT 434
Query: 161 EILNGQSPKA--RAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSK 218
L +S KA RA ++ H+I+VA++ L N SL+A++SAL S SI+RL KTW +S+
Sbjct: 435 TCLGNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKTWEDVSR 494
Query: 219 KDKQQFDKLAELFGETDNWTALREYL------------------------KSISLPCIPY 254
+ F KL+E+F + +N++ RE L I +PY
Sbjct: 495 DSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPKRAQKRPKETGIIQGTVPY 554
Query: 255 LGIFLTDLVYIDIAHPAGSPHRV------TKMNIVLKALERYQS--SEYEIAPLPHVANF 306
LG FLTDLV +D A R+ K V+ ++ QS + Y IAP +
Sbjct: 555 LGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNYSIAPDEQFGAW 614
Query: 307 LNSVRYIEELQKFVEDDQYKLSLKLEPPSPVGS 339
+V ++ E + Y LS +LEPPS S
Sbjct: 615 FRAV------ERLSETESYNLSCELEPPSESAS 641
>AK127524-1|BAC87018.1| 913|Homo sapiens protein ( Homo sapiens
cDNA FLJ45617 fis, clone BRTHA3026916, highly similar
to Ral guanine nucleotide dissociation stimulator. ).
Length = 913
Score = 105 bits (251), Expect = 6e-22
Identities = 88/273 (32%), Positives = 129/273 (47%), Gaps = 43/273 (15%)
Query: 104 PDDVGNQLTLLDLPCFKAIKPEELTTCGWT---KLNKLTVAPNVVAFTKRFNRVSFWTVQ 160
PD V Q TL+D FK + P W+ K K +AP + A +FN V+ +
Sbjct: 386 PDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQFNSVANCVIT 445
Query: 161 EILNGQSPKA--RAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSK 218
L +S KA RA ++ H+I+VA++ L N SL+A++SAL S SI+RL KTW +S+
Sbjct: 446 TCLGNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKTWEDVSR 505
Query: 219 KDKQQFDKLAELFGETDNWTALREYL------------------------KSISLPCIPY 254
+ F KL+E+F + +N++ RE L I +PY
Sbjct: 506 DSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPKRAQKRPKETGIIQGTVPY 565
Query: 255 LGIFLTDLVYIDIAHPAGSPHRV------TKMNIVLKALERYQS--SEYEIAPLPHVANF 306
LG FLTDLV +D A R+ K V+ ++ QS + Y IAP +
Sbjct: 566 LGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNYSIAPDEQFGAW 625
Query: 307 LNSVRYIEELQKFVEDDQYKLSLKLEPPSPVGS 339
+V ++ E + Y LS +LEPPS S
Sbjct: 626 FRAV------ERLSETESYNLSCELEPPSESAS 652
>AK090450-1|BAC03431.1| 625|Homo sapiens FLJ00371 protein protein.
Length = 625
Score = 105 bits (251), Expect = 6e-22
Identities = 88/273 (32%), Positives = 129/273 (47%), Gaps = 43/273 (15%)
Query: 104 PDDVGNQLTLLDLPCFKAIKPEELTTCGWT---KLNKLTVAPNVVAFTKRFNRVSFWTVQ 160
PD V Q TL+D FK + P W+ K K +AP + A +FN V+ +
Sbjct: 176 PDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQFNSVANCVIT 235
Query: 161 EILNGQSPKA--RAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSK 218
L +S KA RA ++ H+I+VA++ L N SL+A++SAL S SI+RL KTW +S+
Sbjct: 236 TCLGNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKTWEDVSR 295
Query: 219 KDKQQFDKLAELFGETDNWTALREYL------------------------KSISLPCIPY 254
+ F KL+E+F + +N++ RE L I +PY
Sbjct: 296 DSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPKRAQKRPKETGIIQGTVPY 355
Query: 255 LGIFLTDLVYIDIAHPAGSPHRV------TKMNIVLKALERYQS--SEYEIAPLPHVANF 306
LG FLTDLV +D A R+ K V+ ++ QS + Y IAP +
Sbjct: 356 LGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNYSIAPDEQFGAW 415
Query: 307 LNSVRYIEELQKFVEDDQYKLSLKLEPPSPVGS 339
+V ++ E + Y LS +LEPPS S
Sbjct: 416 FRAV------ERLSETESYNLSCELEPPSESAS 442
>AK074114-1|BAB84940.1| 824|Homo sapiens FLJ00185 protein protein.
Length = 824
Score = 105 bits (251), Expect = 6e-22
Identities = 88/273 (32%), Positives = 129/273 (47%), Gaps = 43/273 (15%)
Query: 104 PDDVGNQLTLLDLPCFKAIKPEELTTCGWT---KLNKLTVAPNVVAFTKRFNRVSFWTVQ 160
PD V Q TL+D FK + P W+ K K +AP + A +FN V+ +
Sbjct: 375 PDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQFNSVANCVIT 434
Query: 161 EILNGQSPKA--RAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSK 218
L +S KA RA ++ H+I+VA++ L N SL+A++SAL S SI+RL KTW +S+
Sbjct: 435 TCLGNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKTWEDVSR 494
Query: 219 KDKQQFDKLAELFGETDNWTALREYL------------------------KSISLPCIPY 254
+ F KL+E+F + +N++ RE L I +PY
Sbjct: 495 DSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPKRAQKRPKETGIIQGTVPY 554
Query: 255 LGIFLTDLVYIDIAHPAGSPHRV------TKMNIVLKALERYQS--SEYEIAPLPHVANF 306
LG FLTDLV +D A R+ K V+ ++ QS + Y IAP +
Sbjct: 555 LGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNYSIAPDEQFGAW 614
Query: 307 LNSVRYIEELQKFVEDDQYKLSLKLEPPSPVGS 339
+V ++ E + Y LS +LEPPS S
Sbjct: 615 FRAV------ERLSETESYNLSCELEPPSESAS 641
>AF295773-1|AAG02122.1| 914|Homo sapiens ral guanine nucleotide
dissociation stimulator protein.
Length = 914
Score = 105 bits (251), Expect = 6e-22
Identities = 88/273 (32%), Positives = 129/273 (47%), Gaps = 43/273 (15%)
Query: 104 PDDVGNQLTLLDLPCFKAIKPEELTTCGWT---KLNKLTVAPNVVAFTKRFNRVSFWTVQ 160
PD V Q TL+D FK + P W+ K K +AP + A +FN V+ +
Sbjct: 387 PDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQFNSVANCVIT 446
Query: 161 EILNGQSPKA--RAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSK 218
L +S KA RA ++ H+I+VA++ L N SL+A++SAL S SI+RL KTW +S+
Sbjct: 447 TCLGNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKTWEDVSR 506
Query: 219 KDKQQFDKLAELFGETDNWTALREYL------------------------KSISLPCIPY 254
+ F KL+E+F + +N++ RE L I +PY
Sbjct: 507 DSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPKRAQKRPKETGIIQGTVPY 566
Query: 255 LGIFLTDLVYIDIAHPAGSPHRV------TKMNIVLKALERYQS--SEYEIAPLPHVANF 306
LG FLTDLV +D A R+ K V+ ++ QS + Y IAP +
Sbjct: 567 LGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNYSIAPDEQFGAW 626
Query: 307 LNSVRYIEELQKFVEDDQYKLSLKLEPPSPVGS 339
+V ++ E + Y LS +LEPPS S
Sbjct: 627 FRAV------ERLSETESYNLSCELEPPSESAS 653
>AF027169-1|AAQ13414.1| 859|Homo sapiens Ral guanine nucleotide
dissociation stimulator A protein.
Length = 859
Score = 105 bits (251), Expect = 6e-22
Identities = 88/273 (32%), Positives = 129/273 (47%), Gaps = 43/273 (15%)
Query: 104 PDDVGNQLTLLDLPCFKAIKPEELTTCGWT---KLNKLTVAPNVVAFTKRFNRVSFWTVQ 160
PD V Q TL+D FK + P W+ K K +AP + A +FN V+ +
Sbjct: 332 PDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQFNSVANCVIT 391
Query: 161 EILNGQSPKA--RAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSK 218
L +S KA RA ++ H+I+VA++ L N SL+A++SAL S SI+RL KTW +S+
Sbjct: 392 TCLGNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKTWEDVSR 451
Query: 219 KDKQQFDKLAELFGETDNWTALREYL------------------------KSISLPCIPY 254
+ F KL+E+F + +N++ RE L I +PY
Sbjct: 452 DSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPKRAQKRPKETGIIQGTVPY 511
Query: 255 LGIFLTDLVYIDIAHPAGSPHRV------TKMNIVLKALERYQS--SEYEIAPLPHVANF 306
LG FLTDLV +D A R+ K V+ ++ QS + Y IAP +
Sbjct: 512 LGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNYSIAPDEQFGAW 571
Query: 307 LNSVRYIEELQKFVEDDQYKLSLKLEPPSPVGS 339
+V ++ E + Y LS +LEPPS S
Sbjct: 572 FRAV------ERLSETESYNLSCELEPPSESAS 598
>AB037729-1|BAA92546.1| 745|Homo sapiens KIAA1308 protein protein.
Length = 745
Score = 105 bits (251), Expect = 6e-22
Identities = 88/273 (32%), Positives = 129/273 (47%), Gaps = 43/273 (15%)
Query: 104 PDDVGNQLTLLDLPCFKAIKPEELTTCGWT---KLNKLTVAPNVVAFTKRFNRVSFWTVQ 160
PD V Q TL+D FK + P W+ K K +AP + A +FN V+ +
Sbjct: 183 PDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQFNSVANCVIT 242
Query: 161 EILNGQSPKA--RAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSK 218
L +S KA RA ++ H+I+VA++ L N SL+A++SAL S SI+RL KTW +S+
Sbjct: 243 TCLGNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKTWEDVSR 302
Query: 219 KDKQQFDKLAELFGETDNWTALREYL------------------------KSISLPCIPY 254
+ F KL+E+F + +N++ RE L I +PY
Sbjct: 303 DSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPKRAQKRPKETGIIQGTVPY 362
Query: 255 LGIFLTDLVYIDIAHPAGSPHRV------TKMNIVLKALERYQS--SEYEIAPLPHVANF 306
LG FLTDLV +D A R+ K V+ ++ QS + Y IAP +
Sbjct: 363 LGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNYSIAPDEQFGAW 422
Query: 307 LNSVRYIEELQKFVEDDQYKLSLKLEPPSPVGS 339
+V ++ E + Y LS +LEPPS S
Sbjct: 423 FRAV------ERLSETESYNLSCELEPPSESAS 449
>AL355520-6|CAI21922.1| 223|Homo sapiens Ral GEF with PH domain and
SH3 binding motif 2 protein.
Length = 223
Score = 101 bits (241), Expect = 9e-21
Identities = 64/153 (41%), Positives = 86/153 (56%), Gaps = 6/153 (3%)
Query: 276 RVTKMNIVLKAL-ERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEPP 334
R MN +L+ + + QS EY+I LPHV +LNSV+YIEELQKFVEDD YKLSLK+EP
Sbjct: 11 RSNLMNNILRIISDLQQSCEYDIPMLPHVQKYLNSVQYIEELQKFVEDDNYKLSLKIEPG 70
Query: 335 SPVGSCAGSKESVKETVLQGNVTTFNISPSHKLGSGSLRLQGTSHQGKFIP-THRKCRSL 393
+ A S+E + + + + S + G+L Q IP HRKC SL
Sbjct: 71 TSTPRSAASREDLVGPEVGASPQSGRKSVA---AEGALLPQTPPSPRNLIPHGHRKCHSL 127
Query: 394 GSNIFGKSHTEDKMDEKTP-AGSVNLLDDTLLE 425
G N K +T + P AG +LLDD+++E
Sbjct: 128 GYNFIHKMNTAEFKSATFPNAGPRHLLDDSVME 160
>BC111958-1|AAI11959.1| 710|Homo sapiens ral guanine nucleotide
dissociation stimulator-like 3 protein.
Length = 710
Score = 100 bits (239), Expect = 2e-20
Identities = 85/277 (30%), Positives = 131/277 (47%), Gaps = 41/277 (14%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVA---PNVVAFTKRFNRVSF 156
L S D+V QLTL+DL F ++ E W++ ++ A P V A +FN V+
Sbjct: 244 LDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTG 303
Query: 157 WTVQEILN--GQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWA 214
+ +L G + RA+ + +I++A++ EL N SL A++SAL S IYRL ++W
Sbjct: 304 CVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWG 363
Query: 215 CLSKKDKQQFDKLAELFGETDNWTALREYL--------------KSISLPC------IPY 254
+S++ F KL+++F + +N + RE L SLP +PY
Sbjct: 364 AVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPY 423
Query: 255 LGIFLTDLVYIDIAHP---AGSPHRVTKMNIVLKALERYQS-----SEYEIAPLPHVANF 306
LG FLTDLV +D A P G K + L R Q Y ++P P +
Sbjct: 424 LGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAA 483
Query: 307 LNSVRYIEELQKFVEDDQYKLSLKLEPPSPVGSCAGS 343
L++ + E+ Y+LS +EPP+ SC S
Sbjct: 484 LHA------QNQLTEEQSYRLSRVIEPPA--ASCPSS 512
>BC101756-1|AAI01757.1| 710|Homo sapiens ral guanine nucleotide
dissociation stimulator-like 3 protein.
Length = 710
Score = 100 bits (239), Expect = 2e-20
Identities = 85/277 (30%), Positives = 131/277 (47%), Gaps = 41/277 (14%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVA---PNVVAFTKRFNRVSF 156
L S D+V QLTL+DL F ++ E W++ ++ A P V A +FN V+
Sbjct: 244 LDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTG 303
Query: 157 WTVQEILN--GQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWA 214
+ +L G + RA+ + +I++A++ EL N SL A++SAL S IYRL ++W
Sbjct: 304 CVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWG 363
Query: 215 CLSKKDKQQFDKLAELFGETDNWTALREYL--------------KSISLPC------IPY 254
+S++ F KL+++F + +N + RE L SLP +PY
Sbjct: 364 AVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPY 423
Query: 255 LGIFLTDLVYIDIAHP---AGSPHRVTKMNIVLKALERYQS-----SEYEIAPLPHVANF 306
LG FLTDLV +D A P G K + L R Q Y ++P P +
Sbjct: 424 LGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAA 483
Query: 307 LNSVRYIEELQKFVEDDQYKLSLKLEPPSPVGSCAGS 343
L++ + E+ Y+LS +EPP+ SC S
Sbjct: 484 LHA------QNQLTEEQSYRLSRVIEPPA--ASCPSS 512
>AK074082-1|BAB84908.1| 497|Homo sapiens FLJ00153 protein protein.
Length = 497
Score = 100 bits (239), Expect = 2e-20
Identities = 85/277 (30%), Positives = 131/277 (47%), Gaps = 41/277 (14%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVA---PNVVAFTKRFNRVSF 156
L S D+V QLTL+DL F ++ E W++ ++ A P V A +FN V+
Sbjct: 41 LDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTG 100
Query: 157 WTVQEILN--GQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWA 214
+ +L G + RA+ + +I++A++ EL N SL A++SAL S IYRL ++W
Sbjct: 101 CVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWG 160
Query: 215 CLSKKDKQQFDKLAELFGETDNWTALREYL--------------KSISLPC------IPY 254
+S++ F KL+++F + +N + RE L SLP +PY
Sbjct: 161 AVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPY 220
Query: 255 LGIFLTDLVYIDIAHP---AGSPHRVTKMNIVLKALERYQS-----SEYEIAPLPHVANF 306
LG FLTDLV +D A P G K + L R Q Y ++P P +
Sbjct: 221 LGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAA 280
Query: 307 LNSVRYIEELQKFVEDDQYKLSLKLEPPSPVGSCAGS 343
L++ + E+ Y+LS +EPP+ SC S
Sbjct: 281 LHA------QNQLTEEQSYRLSRVIEPPA--ASCPSS 309
>BC117321-1|AAI17322.1| 1486|Homo sapiens RAPGEF2 protein protein.
Length = 1486
Score = 96.7 bits (230), Expect = 2e-19
Identities = 58/170 (34%), Positives = 86/170 (50%), Gaps = 3/170 (1%)
Query: 98 SALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFW 157
S L+LS +V QL++ + F+ I+P E KL T N+ F + N+ +FW
Sbjct: 700 SLLQLSTVEVATQLSMRNFELFRNIEPTEYID-DLFKLRSKTSCANLKRFEEVINQETFW 758
Query: 158 TVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLS 217
EIL + R +I+ HFIK+A E N +S+FA+IS L+ A + RL TW L
Sbjct: 759 VASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLP 818
Query: 218 KKDKQQFDKLAELFGETDNWTALREYLKSISL--PCIPYLGIFLTDLVYI 265
K ++ F L +LF + N R L S +L P IP + DL ++
Sbjct: 819 NKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFL 868
>AC074344-1|AAY40909.1| 1479|Homo sapiens unknown protein.
Length = 1479
Score = 96.7 bits (230), Expect = 2e-19
Identities = 58/170 (34%), Positives = 86/170 (50%), Gaps = 3/170 (1%)
Query: 98 SALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFW 157
S L+LS +V QL++ + F+ I+P E KL T N+ F + N+ +FW
Sbjct: 692 SLLQLSTVEVATQLSMRNFELFRNIEPTEYID-DLFKLRSKTSCANLKRFEEVINQETFW 750
Query: 158 TVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLS 217
EIL + R +I+ HFIK+A E N +S+FA+IS L+ A + RL TW L
Sbjct: 751 VASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLP 810
Query: 218 KKDKQQFDKLAELFGETDNWTALREYLKSISL--PCIPYLGIFLTDLVYI 265
K ++ F L +LF + N R L S +L P IP + DL ++
Sbjct: 811 NKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFL 860
>AB002311-1|BAA20772.2| 1508|Homo sapiens KIAA0313 protein.
Length = 1508
Score = 96.7 bits (230), Expect = 2e-19
Identities = 58/170 (34%), Positives = 86/170 (50%), Gaps = 3/170 (1%)
Query: 98 SALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFW 157
S L+LS +V QL++ + F+ I+P E KL T N+ F + N+ +FW
Sbjct: 721 SLLQLSTVEVATQLSMRNFELFRNIEPTEYID-DLFKLRSKTSCANLKRFEEVINQETFW 779
Query: 158 TVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLS 217
EIL + R +I+ HFIK+A E N +S+FA+IS L+ A + RL TW L
Sbjct: 780 VASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLP 839
Query: 218 KKDKQQFDKLAELFGETDNWTALREYLKSISL--PCIPYLGIFLTDLVYI 265
K ++ F L +LF + N R L S +L P IP + DL ++
Sbjct: 840 NKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFL 889
>BC133703-1|AAI33704.1| 1504|Homo sapiens RAPGEF6 protein protein.
Length = 1504
Score = 95.1 bits (226), Expect = 6e-19
Identities = 57/170 (33%), Positives = 86/170 (50%), Gaps = 3/170 (1%)
Query: 98 SALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFW 157
S L+LS +V QL++ D F+ I+P E KLN T ++ F N+ +FW
Sbjct: 855 SMLQLSTIEVATQLSMRDFDLFRNIEPTEYID-DLFKLNSKTGNTHLKRFEDIVNQETFW 913
Query: 158 TVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLS 217
EIL + R +I+ HFIK+A E N +S+FA+IS L+ AS+ RL TW L
Sbjct: 914 VASEILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLP 973
Query: 218 KKDKQQFDKLAELFGETDNWTALREYLKSISL--PCIPYLGIFLTDLVYI 265
K ++ L ++F + N R L S S+ P IP + D+ ++
Sbjct: 974 SKYEKHLQDLQDIFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFL 1023
>AK074318-1|BAB85049.1| 1113|Homo sapiens protein ( Homo sapiens
cDNA FLJ23738 fis, clone HEP15081, highly similar to PDZ
domain-containing guanine nucleotide exchange factor I.
).
Length = 1113
Score = 95.1 bits (226), Expect = 6e-19
Identities = 57/170 (33%), Positives = 86/170 (50%), Gaps = 3/170 (1%)
Query: 98 SALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFW 157
S L+LS +V QL++ D F+ I+P E KLN T ++ F N+ +FW
Sbjct: 569 SMLQLSTIEVATQLSMRDFDLFRNIEPTEYID-DLFKLNSKTGNTHLKRFEDIVNQETFW 627
Query: 158 TVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLS 217
EIL + R +I+ HFIK+A E N +S+FA+IS L+ AS+ RL TW L
Sbjct: 628 VASEILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLP 687
Query: 218 KKDKQQFDKLAELFGETDNWTALREYLKSISL--PCIPYLGIFLTDLVYI 265
K ++ L ++F + N R L S S+ P IP + D+ ++
Sbjct: 688 SKYEKHLQDLQDIFDPSRNMAKYRNILSSQSMRPPIIPLFPVVKKDMTFL 737
>AF478567-1|AAM21637.1| 1601|Homo sapiens PDZ domain-containing
guanine nucleotide exchange factor PDZ-GEF2 protein.
Length = 1601
Score = 95.1 bits (226), Expect = 6e-19
Identities = 57/170 (33%), Positives = 86/170 (50%), Gaps = 3/170 (1%)
Query: 98 SALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFW 157
S L+LS +V QL++ D F+ I+P E KLN T ++ F N+ +FW
Sbjct: 855 SMLQLSTIEVATQLSMRDFDLFRNIEPTEYID-DLFKLNSKTGNTHLKRFEDIVNQETFW 913
Query: 158 TVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLS 217
EIL + R +I+ HFIK+A E N +S+FA+IS L+ AS+ RL TW L
Sbjct: 914 VASEILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLP 973
Query: 218 KKDKQQFDKLAELFGETDNWTALREYLKSISL--PCIPYLGIFLTDLVYI 265
K ++ L ++F + N R L S S+ P IP + D+ ++
Sbjct: 974 SKYEKHLQDLQDIFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFL 1023
>AF478469-1|AAL79916.1| 1391|Homo sapiens Rap1 guanine
nucleotide-exchange factor PDZ-GEF2B protein.
Length = 1391
Score = 95.1 bits (226), Expect = 6e-19
Identities = 57/170 (33%), Positives = 86/170 (50%), Gaps = 3/170 (1%)
Query: 98 SALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFW 157
S L+LS +V QL++ D F+ I+P E KLN T ++ F N+ +FW
Sbjct: 855 SMLQLSTIEVATQLSMRDFDLFRNIEPTEYID-DLFKLNSKTGNTHLKRFEDIVNQETFW 913
Query: 158 TVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLS 217
EIL + R +I+ HFIK+A E N +S+FA+IS L+ AS+ RL TW L
Sbjct: 914 VASEILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLP 973
Query: 218 KKDKQQFDKLAELFGETDNWTALREYLKSISL--PCIPYLGIFLTDLVYI 265
K ++ L ++F + N R L S S+ P IP + D+ ++
Sbjct: 974 SKYEKHLQDLQDIFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFL 1023
>AF478468-1|AAL79915.1| 1601|Homo sapiens Rap1 guanine
nucleotide-exchange factor PDZ-GEF2A protein.
Length = 1601
Score = 95.1 bits (226), Expect = 6e-19
Identities = 57/170 (33%), Positives = 86/170 (50%), Gaps = 3/170 (1%)
Query: 98 SALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFW 157
S L+LS +V QL++ D F+ I+P E KLN T ++ F N+ +FW
Sbjct: 855 SMLQLSTIEVATQLSMRDFDLFRNIEPTEYID-DLFKLNSKTGNTHLKRFEDIVNQETFW 913
Query: 158 TVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLS 217
EIL + R +I+ HFIK+A E N +S+FA+IS L+ AS+ RL TW L
Sbjct: 914 VASEILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLP 973
Query: 218 KKDKQQFDKLAELFGETDNWTALREYLKSISL--PCIPYLGIFLTDLVYI 265
K ++ L ++F + N R L S S+ P IP + D+ ++
Sbjct: 974 SKYEKHLQDLQDIFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFL 1023
>AF394782-1|AAK83368.1| 1509|Homo sapiens rap guanine nucleotide
exchange factor protein.
Length = 1509
Score = 95.1 bits (226), Expect = 6e-19
Identities = 57/170 (33%), Positives = 86/170 (50%), Gaps = 3/170 (1%)
Query: 98 SALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFW 157
S L+LS +V QL++ D F+ I+P E KLN T ++ F N+ +FW
Sbjct: 860 SMLQLSTIEVATQLSMRDFDLFRNIEPTEYID-DLFKLNSKTGNTHLKRFEDIVNQETFW 918
Query: 158 TVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLS 217
EIL + R +I+ HFIK+A E N +S+FA+IS L+ AS+ RL TW L
Sbjct: 919 VASEILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLP 978
Query: 218 KKDKQQFDKLAELFGETDNWTALREYLKSISL--PCIPYLGIFLTDLVYI 265
K ++ L ++F + N R L S S+ P IP + D+ ++
Sbjct: 979 SKYEKHLQDLQDIFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFL 1028
>AF117947-1|AAF22004.1| 1204|Homo sapiens PDZ domain-containing
guanine nucleotide exchange factor I protein.
Length = 1204
Score = 95.1 bits (226), Expect = 6e-19
Identities = 57/170 (33%), Positives = 86/170 (50%), Gaps = 3/170 (1%)
Query: 98 SALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFW 157
S L+LS +V QL++ D F+ I+P E KLN T ++ F N+ +FW
Sbjct: 905 SMLQLSTIEVATQLSMRDFDLFRNIEPTEYID-DLFKLNSKTGNTHLKRFEDIVNQETFW 963
Query: 158 TVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLS 217
EIL + R +I+ HFIK+A E N +S+FA+IS L+ AS+ RL TW L
Sbjct: 964 VASEILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLP 1023
Query: 218 KKDKQQFDKLAELFGETDNWTALREYLKSISL--PCIPYLGIFLTDLVYI 265
K ++ L ++F + N R L S S+ P IP + D+ ++
Sbjct: 1024 SKYEKHLQDLQDIFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFL 1073
>BC027849-1|AAH27849.1| 690|Homo sapiens RAS guanyl releasing
protein 3 (calcium and DAG-regulated) protein.
Length = 690
Score = 93.9 bits (223), Expect = 1e-18
Identities = 67/238 (28%), Positives = 114/238 (47%), Gaps = 12/238 (5%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQE 161
L P ++ LT L+ F+ I + + + L P + FN +S W
Sbjct: 151 LEPIELAEHLTFLEHKSFRRISFTDYQS--YVIHGCLENNPTLERSIALFNGISKWVQLM 208
Query: 162 ILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDK 221
+L+ +P+ RAE++ FI VAKKL +L N ++L AV+ L +SI RL +T + LS +
Sbjct: 209 VLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVT 268
Query: 222 QQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPH------ 275
+ ++++ EL N+ R+ IP LG+ L DL+ + + P +
Sbjct: 269 KNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTEENKVNIV 328
Query: 276 RVTKMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEP 333
++ ++++ L L Q++ + + P + N L + EDD YKLSL LEP
Sbjct: 329 KMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYH----TEDDIYKLSLVLEP 382
>AC020594-2|AAY15037.1| 690|Homo sapiens unknown protein.
Length = 690
Score = 93.9 bits (223), Expect = 1e-18
Identities = 67/238 (28%), Positives = 114/238 (47%), Gaps = 12/238 (5%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQE 161
L P ++ LT L+ F+ I + + + L P + FN +S W
Sbjct: 151 LEPIELAEHLTFLEHKSFRRISFTDYQS--YVIHGCLENNPTLERSIALFNGISKWVQLM 208
Query: 162 ILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDK 221
+L+ +P+ RAE++ FI VAKKL +L N ++L AV+ L +SI RL +T + LS +
Sbjct: 209 VLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVT 268
Query: 222 QQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPH------ 275
+ ++++ EL N+ R+ IP LG+ L DL+ + + P +
Sbjct: 269 KNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTEENKVNIV 328
Query: 276 RVTKMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEP 333
++ ++++ L L Q++ + + P + N L + EDD YKLSL LEP
Sbjct: 329 KMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYH----TEDDIYKLSLVLEP 382
>AB020653-1|BAA74869.2| 691|Homo sapiens KIAA0846 protein protein.
Length = 691
Score = 93.9 bits (223), Expect = 1e-18
Identities = 67/238 (28%), Positives = 114/238 (47%), Gaps = 12/238 (5%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQE 161
L P ++ LT L+ F+ I + + + L P + FN +S W
Sbjct: 153 LEPIELAEHLTFLEHKSFRRISFTDYQS--YVIHGCLENNPTLERSIALFNGISKWVQLM 210
Query: 162 ILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDK 221
+L+ +P+ RAE++ FI VAKKL +L N ++L AV+ L +SI RL +T + LS +
Sbjct: 211 VLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVT 270
Query: 222 QQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPH------ 275
+ ++++ EL N+ R+ IP LG+ L DL+ + + P +
Sbjct: 271 KNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTEENKVNIV 330
Query: 276 RVTKMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEP 333
++ ++++ L L Q++ + + P + N L + EDD YKLSL LEP
Sbjct: 331 KMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYH----TEDDIYKLSLVLEP 384
>AL355520-8|CAI21924.1| 145|Homo sapiens Ral GEF with PH domain and
SH3 binding motif 2 protein.
Length = 145
Score = 92.3 bits (219), Expect = 4e-18
Identities = 40/93 (43%), Positives = 61/93 (65%), Gaps = 1/93 (1%)
Query: 455 QGCVKRKTILKEGRKISLSSWQRYWLQMSGNMLFFYGAKSFKGTNRSDFRSERCKVLTLV 514
QG ++RKT+LKEG+K +++SW +YW + G LF+Y AKS K T R F+S K ++++
Sbjct: 51 QGVLRRKTLLKEGKKPTVASWTKYWAALCGTQLFYYAAKSLKATERKHFKSTSNKNVSVI 110
Query: 515 GWIAVWADG-DAADAFQLINHHSGTVYKFKAGS 546
GW+ + AD + D F L + G YKF+AG+
Sbjct: 111 GWMVMMADDPEHPDLFLLTDSEKGNSYKFQAGN 143
>BX537416-1|CAD97658.1| 803|Homo sapiens hypothetical protein
protein.
Length = 803
Score = 91.5 bits (217), Expect = 7e-18
Identities = 53/147 (36%), Positives = 80/147 (54%), Gaps = 5/147 (3%)
Query: 103 SPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLT---VAPNVVAFTKRFNRVSFWTV 159
S D V QLT +D FK + P C W++ +K +AP + A +FN ++ V
Sbjct: 267 SEDLVAEQLTYMDAQLFKKVVPHHCLGCIWSRRDKKENKHLAPTIRATISQFNTLTKCVV 326
Query: 160 QEILNGQSPKA--RAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLS 217
IL G+ K RA+I+ +I +A + L N SL A++SAL S SIYRL KTWA +
Sbjct: 327 STILGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRLKKTWAAVP 386
Query: 218 KKDKQQFDKLAELFGETDNWTALREYL 244
+ F++L+++F + +N RE L
Sbjct: 387 RDRMLMFEELSDIFSDHNNHLTSRELL 413
>AL592299-5|CAI14724.1| 768|Homo sapiens ral guanine nucleotide
dissociation stimulator-like 1 protein.
Length = 768
Score = 91.5 bits (217), Expect = 7e-18
Identities = 53/147 (36%), Positives = 80/147 (54%), Gaps = 5/147 (3%)
Query: 103 SPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLT---VAPNVVAFTKRFNRVSFWTV 159
S D V QLT +D FK + P C W++ +K +AP + A +FN ++ V
Sbjct: 232 SEDLVAEQLTYMDAQLFKKVVPHHCLGCIWSRRDKKENKHLAPTIRATISQFNTLTKCVV 291
Query: 160 QEILNGQSPKA--RAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLS 217
IL G+ K RA+I+ +I +A + L N SL A++SAL S SIYRL KTWA +
Sbjct: 292 STILGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRLKKTWAAVP 351
Query: 218 KKDKQQFDKLAELFGETDNWTALREYL 244
+ F++L+++F + +N RE L
Sbjct: 352 RDRMLMFEELSDIFSDHNNHLTSRELL 378
>AL592299-1|CAI14720.1| 803|Homo sapiens ral guanine nucleotide
dissociation stimulator-like 1 protein.
Length = 803
Score = 91.5 bits (217), Expect = 7e-18
Identities = 53/147 (36%), Positives = 80/147 (54%), Gaps = 5/147 (3%)
Query: 103 SPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLT---VAPNVVAFTKRFNRVSFWTV 159
S D V QLT +D FK + P C W++ +K +AP + A +FN ++ V
Sbjct: 267 SEDLVAEQLTYMDAQLFKKVVPHHCLGCIWSRRDKKENKHLAPTIRATISQFNTLTKCVV 326
Query: 160 QEILNGQSPKA--RAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLS 217
IL G+ K RA+I+ +I +A + L N SL A++SAL S SIYRL KTWA +
Sbjct: 327 STILGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRLKKTWAAVP 386
Query: 218 KKDKQQFDKLAELFGETDNWTALREYL 244
+ F++L+++F + +N RE L
Sbjct: 387 RDRMLMFEELSDIFSDHNNHLTSRELL 413
>AL590422-2|CAH73874.1| 768|Homo sapiens ral guanine nucleotide
dissociation stimulator-like 1 protein.
Length = 768
Score = 91.5 bits (217), Expect = 7e-18
Identities = 53/147 (36%), Positives = 80/147 (54%), Gaps = 5/147 (3%)
Query: 103 SPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLT---VAPNVVAFTKRFNRVSFWTV 159
S D V QLT +D FK + P C W++ +K +AP + A +FN ++ V
Sbjct: 232 SEDLVAEQLTYMDAQLFKKVVPHHCLGCIWSRRDKKENKHLAPTIRATISQFNTLTKCVV 291
Query: 160 QEILNGQSPKA--RAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLS 217
IL G+ K RA+I+ +I +A + L N SL A++SAL S SIYRL KTWA +
Sbjct: 292 STILGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRLKKTWAAVP 351
Query: 218 KKDKQQFDKLAELFGETDNWTALREYL 244
+ F++L+++F + +N RE L
Sbjct: 352 RDRMLMFEELSDIFSDHNNHLTSRELL 378
>AL590422-1|CAH73873.1| 803|Homo sapiens ral guanine nucleotide
dissociation stimulator-like 1 protein.
Length = 803
Score = 91.5 bits (217), Expect = 7e-18
Identities = 53/147 (36%), Positives = 80/147 (54%), Gaps = 5/147 (3%)
Query: 103 SPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLT---VAPNVVAFTKRFNRVSFWTV 159
S D V QLT +D FK + P C W++ +K +AP + A +FN ++ V
Sbjct: 267 SEDLVAEQLTYMDAQLFKKVVPHHCLGCIWSRRDKKENKHLAPTIRATISQFNTLTKCVV 326
Query: 160 QEILNGQSPKA--RAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLS 217
IL G+ K RA+I+ +I +A + L N SL A++SAL S SIYRL KTWA +
Sbjct: 327 STILGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRLKKTWAAVP 386
Query: 218 KKDKQQFDKLAELFGETDNWTALREYL 244
+ F++L+++F + +N RE L
Sbjct: 387 RDRMLMFEELSDIFSDHNNHLTSRELL 413
>AL080117-1|CAB45716.1| 754|Homo sapiens hypothetical protein
protein.
Length = 754
Score = 91.5 bits (217), Expect = 7e-18
Identities = 53/147 (36%), Positives = 80/147 (54%), Gaps = 5/147 (3%)
Query: 103 SPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLT---VAPNVVAFTKRFNRVSFWTV 159
S D V QLT +D FK + P C W++ +K +AP + A +FN ++ V
Sbjct: 218 SEDLVAEQLTYMDAQLFKKVVPHHCLGCIWSRRDKKENKHLAPTIRATISQFNTLTKCVV 277
Query: 160 QEILNGQSPKA--RAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLS 217
IL G+ K RA+I+ +I +A + L N SL A++SAL S SIYRL KTWA +
Sbjct: 278 STILGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRLKKTWAAVP 337
Query: 218 KKDKQQFDKLAELFGETDNWTALREYL 244
+ F++L+++F + +N RE L
Sbjct: 338 RDRMLMFEELSDIFSDHNNHLTSRELL 364
>AF186798-2|AAG14401.1| 803|Homo sapiens RalGDS-like protein.
Length = 803
Score = 91.5 bits (217), Expect = 7e-18
Identities = 53/147 (36%), Positives = 80/147 (54%), Gaps = 5/147 (3%)
Query: 103 SPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLT---VAPNVVAFTKRFNRVSFWTV 159
S D V QLT +D FK + P C W++ +K +AP + A +FN ++ V
Sbjct: 267 SEDLVAEQLTYMDAQLFKKVVPHHCLGCIWSRRDKKENKHLAPTIRATISQFNTLTKCVV 326
Query: 160 QEILNGQSPKA--RAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLS 217
IL G+ K RA+I+ +I +A + L N SL A++SAL S SIYRL KTWA +
Sbjct: 327 STILGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRLKKTWAAVP 386
Query: 218 KKDKQQFDKLAELFGETDNWTALREYL 244
+ F++L+++F + +N RE L
Sbjct: 387 RDRMLMFEELSDIFSDHNNHLTSRELL 413
>AF186798-1|AAG14400.1| 768|Homo sapiens RalGDS-like protein.
Length = 768
Score = 91.5 bits (217), Expect = 7e-18
Identities = 53/147 (36%), Positives = 80/147 (54%), Gaps = 5/147 (3%)
Query: 103 SPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLT---VAPNVVAFTKRFNRVSFWTV 159
S D V QLT +D FK + P C W++ +K +AP + A +FN ++ V
Sbjct: 232 SEDLVAEQLTYMDAQLFKKVVPHHCLGCIWSRRDKKENKHLAPTIRATISQFNTLTKCVV 291
Query: 160 QEILNGQSPKA--RAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLS 217
IL G+ K RA+I+ +I +A + L N SL A++SAL S SIYRL KTWA +
Sbjct: 292 STILGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRLKKTWAAVP 351
Query: 218 KKDKQQFDKLAELFGETDNWTALREYL 244
+ F++L+++F + +N RE L
Sbjct: 352 RDRMLMFEELSDIFSDHNNHLTSRELL 378
>AF186780-1|AAF67281.1| 803|Homo sapiens RGL protein protein.
Length = 803
Score = 91.5 bits (217), Expect = 7e-18
Identities = 53/147 (36%), Positives = 80/147 (54%), Gaps = 5/147 (3%)
Query: 103 SPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLT---VAPNVVAFTKRFNRVSFWTV 159
S D V QLT +D FK + P C W++ +K +AP + A +FN ++ V
Sbjct: 267 SEDLVAEQLTYMDAQLFKKVVPHHCLGCIWSRRDKKENKHLAPTIRATISQFNTLTKCVV 326
Query: 160 QEILNGQSPKA--RAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLS 217
IL G+ K RA+I+ +I +A + L N SL A++SAL S SIYRL KTWA +
Sbjct: 327 STILGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRLKKTWAAVP 386
Query: 218 KKDKQQFDKLAELFGETDNWTALREYL 244
+ F++L+++F + +N RE L
Sbjct: 387 RDRMLMFEELSDIFSDHNNHLTSRELL 413
>AF186779-1|AAF67280.1| 768|Homo sapiens RGL protein protein.
Length = 768
Score = 91.5 bits (217), Expect = 7e-18
Identities = 53/147 (36%), Positives = 80/147 (54%), Gaps = 5/147 (3%)
Query: 103 SPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLT---VAPNVVAFTKRFNRVSFWTV 159
S D V QLT +D FK + P C W++ +K +AP + A +FN ++ V
Sbjct: 232 SEDLVAEQLTYMDAQLFKKVVPHHCLGCIWSRRDKKENKHLAPTIRATISQFNTLTKCVV 291
Query: 160 QEILNGQSPKA--RAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLS 217
IL G+ K RA+I+ +I +A + L N SL A++SAL S SIYRL KTWA +
Sbjct: 292 STILGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRLKKTWAAVP 351
Query: 218 KKDKQQFDKLAELFGETDNWTALREYL 244
+ F++L+++F + +N RE L
Sbjct: 352 RDRMLMFEELSDIFSDHNNHLTSRELL 378
>AB023176-1|BAA76803.1| 820|Homo sapiens KIAA0959 protein protein.
Length = 820
Score = 91.5 bits (217), Expect = 7e-18
Identities = 53/147 (36%), Positives = 80/147 (54%), Gaps = 5/147 (3%)
Query: 103 SPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLT---VAPNVVAFTKRFNRVSFWTV 159
S D V QLT +D FK + P C W++ +K +AP + A +FN ++ V
Sbjct: 284 SEDLVAEQLTYMDAQLFKKVVPHHCLGCIWSRRDKKENKHLAPTIRATISQFNTLTKCVV 343
Query: 160 QEILNGQSPKA--RAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLS 217
IL G+ K RA+I+ +I +A + L N SL A++SAL S SIYRL KTWA +
Sbjct: 344 STILGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRLKKTWAAVP 403
Query: 218 KKDKQQFDKLAELFGETDNWTALREYL 244
+ F++L+++F + +N RE L
Sbjct: 404 RDRMLMFEELSDIFSDHNNHLTSRELL 430
>BC092404-1|AAH92404.1| 881|Homo sapiens Rap guanine nucleotide
exchange factor (GEF) 3 protein.
Length = 881
Score = 90.6 bits (215), Expect = 1e-17
Identities = 56/166 (33%), Positives = 84/166 (50%), Gaps = 3/166 (1%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELT--TCGWTKLNKLTVAPNVVAFTKRFNRVSFWTV 159
+S D+ QLT D F +I EL G L +T A N+ F +RFN + +W
Sbjct: 619 VSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTA-NLERFMRRFNELQYWVA 677
Query: 160 QEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKK 219
E+ P RA+++ FIK+A L E NL+S FAV+ L +++I RL TW L K
Sbjct: 678 TELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHK 737
Query: 220 DKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYI 265
++ + L L + N R L +S P IP++ + L D+ +I
Sbjct: 738 VRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFI 783
>BC017728-1|AAH17728.1| 881|Homo sapiens Rap guanine nucleotide
exchange factor (GEF) 3 protein.
Length = 881
Score = 90.6 bits (215), Expect = 1e-17
Identities = 56/166 (33%), Positives = 84/166 (50%), Gaps = 3/166 (1%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELT--TCGWTKLNKLTVAPNVVAFTKRFNRVSFWTV 159
+S D+ QLT D F +I EL G L +T A N+ F +RFN + +W
Sbjct: 619 VSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTA-NLERFMRRFNELQYWVA 677
Query: 160 QEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKK 219
E+ P RA+++ FIK+A L E NL+S FAV+ L +++I RL TW L K
Sbjct: 678 TELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHK 737
Query: 220 DKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYI 265
++ + L L + N R L +S P IP++ + L D+ +I
Sbjct: 738 VRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFI 783
>AF103905-1|AAC83381.1| 881|Homo sapiens Rap1 guanine-nucleotide
exchange factor protein.
Length = 881
Score = 90.6 bits (215), Expect = 1e-17
Identities = 56/166 (33%), Positives = 84/166 (50%), Gaps = 3/166 (1%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELT--TCGWTKLNKLTVAPNVVAFTKRFNRVSFWTV 159
+S D+ QLT D F +I EL G L +T A N+ F +RFN + +W
Sbjct: 619 VSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTA-NLERFMRRFNELQYWVA 677
Query: 160 QEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKK 219
E+ P RA+++ FIK+A L E NL+S FAV+ L +++I RL TW L K
Sbjct: 678 TELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHK 737
Query: 220 DKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYI 265
++ + L L + N R L +S P IP++ + L D+ +I
Sbjct: 738 VRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFI 783
>BC040183-1|AAH40183.1| 867|Homo sapiens RAPGEF4 protein protein.
Length = 867
Score = 89.0 bits (211), Expect = 4e-17
Identities = 63/243 (25%), Positives = 108/243 (44%), Gaps = 10/243 (4%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQE 161
+S D+ Q+T+ D F + EL + + N N+ F +RFN + FW V E
Sbjct: 627 MSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTE 686
Query: 162 ILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDK 221
I R +++ FIK+A E NL+S FA++ L + ++ RL TW L K K
Sbjct: 687 ICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFK 746
Query: 222 QQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPHRVT--K 279
+ + + L + N A R + + P IP++ + + D+ + + + V K
Sbjct: 747 KFYAEFESLMDTSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEK 806
Query: 280 MNIV---LKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSL---KLEP 333
M ++ + + Y+S + N + Y+ +L V D+Q LS +LEP
Sbjct: 807 MRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLN--VIDNQRTLSQMSHRLEP 864
Query: 334 PSP 336
P
Sbjct: 865 RRP 867
>BC024004-1|AAH24004.1| 1011|Homo sapiens Rap guanine nucleotide
exchange factor (GEF) 4 protein.
Length = 1011
Score = 89.0 bits (211), Expect = 4e-17
Identities = 63/243 (25%), Positives = 108/243 (44%), Gaps = 10/243 (4%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQE 161
+S D+ Q+T+ D F + EL + + N N+ F +RFN + FW V E
Sbjct: 771 MSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTE 830
Query: 162 ILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDK 221
I R +++ FIK+A E NL+S FA++ L + ++ RL TW L K K
Sbjct: 831 ICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFK 890
Query: 222 QQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPHRVT--K 279
+ + + L + N A R + + P IP++ + + D+ + + + V K
Sbjct: 891 KFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEK 950
Query: 280 MNIV---LKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSL---KLEP 333
M ++ + + Y+S + N + Y+ +L V D+Q LS +LEP
Sbjct: 951 MRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLN--VIDNQRTLSQMSHRLEP 1008
Query: 334 PSP 336
P
Sbjct: 1009 RRP 1011
>AB209681-1|BAD92918.1| 643|Homo sapiens RAP
guanine-nucleotide-exchange factor 4 variant protein.
Length = 643
Score = 89.0 bits (211), Expect = 4e-17
Identities = 63/243 (25%), Positives = 108/243 (44%), Gaps = 10/243 (4%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQE 161
+S D+ Q+T+ D F + EL + + N N+ F +RFN + FW V E
Sbjct: 403 MSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTE 462
Query: 162 ILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDK 221
I R +++ FIK+A E NL+S FA++ L + ++ RL TW L K K
Sbjct: 463 ICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFK 522
Query: 222 QQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPHRVT--K 279
+ + + L + N A R + + P IP++ + + D+ + + + V K
Sbjct: 523 KFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEK 582
Query: 280 MNIV---LKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSL---KLEP 333
M ++ + + Y+S + N + Y+ +L V D+Q LS +LEP
Sbjct: 583 MRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLN--VIDNQRTLSQMSHRLEP 640
Query: 334 PSP 336
P
Sbjct: 641 RRP 643
>AB075513-1|BAE45759.1| 478|Homo sapiens putative protein product
of Nbla00496 protein.
Length = 478
Score = 89.0 bits (211), Expect = 4e-17
Identities = 63/243 (25%), Positives = 108/243 (44%), Gaps = 10/243 (4%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQE 161
+S D+ Q+T+ D F + EL + + N N+ F +RFN + FW V E
Sbjct: 238 MSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTE 297
Query: 162 ILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDK 221
I R +++ FIK+A E NL+S FA++ L + ++ RL TW L K K
Sbjct: 298 ICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFK 357
Query: 222 QQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPHRVT--K 279
+ + + L + N A R + + P IP++ + + D+ + + + V K
Sbjct: 358 KFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEK 417
Query: 280 MNIV---LKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSL---KLEP 333
M ++ + + Y+S + N + Y+ +L V D+Q LS +LEP
Sbjct: 418 MRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLN--VIDNQRTLSQMSHRLEP 475
Query: 334 PSP 336
P
Sbjct: 476 RRP 478
>AB027471-1|BAB72179.1| 1011|Homo sapiens cAMP-GEFII protein.
Length = 1011
Score = 89.0 bits (211), Expect = 4e-17
Identities = 63/243 (25%), Positives = 108/243 (44%), Gaps = 10/243 (4%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQE 161
+S D+ Q+T+ D F + EL + + N N+ F +RFN + FW V E
Sbjct: 771 MSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTE 830
Query: 162 ILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDK 221
I R +++ FIK+A E NL+S FA++ L + ++ RL TW L K K
Sbjct: 831 ICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFK 890
Query: 222 QQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPHRVT--K 279
+ + + L + N A R + + P IP++ + + D+ + + + V K
Sbjct: 891 KFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEK 950
Query: 280 MNIV---LKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSL---KLEP 333
M ++ + + Y+S + N + Y+ +L V D+Q LS +LEP
Sbjct: 951 MRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLN--VIDNQRTLSQMSHRLEP 1008
Query: 334 PSP 336
P
Sbjct: 1009 RRP 1011
>U78516-1|AAD03422.1| 1011|Homo sapiens cAMP-regulated guanine
nucleotide exchange factor II protein.
Length = 1011
Score = 88.6 bits (210), Expect = 5e-17
Identities = 63/243 (25%), Positives = 108/243 (44%), Gaps = 10/243 (4%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQE 161
+S D+ Q+T+ D F + EL + + N N+ F +RFN + FW V E
Sbjct: 771 MSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTE 830
Query: 162 ILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDK 221
I R +++ FIK+A E NL+S FA++ L + ++ RL TW L K K
Sbjct: 831 ICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNIAVSRLALTWEKLPSKFK 890
Query: 222 QQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPHRVT--K 279
+ + + L + N A R + + P IP++ + + D+ + + + V K
Sbjct: 891 KFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEK 950
Query: 280 MNIV---LKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSL---KLEP 333
M ++ + + Y+S + N + Y+ +L V D+Q LS +LEP
Sbjct: 951 MRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLN--VIDNQRTLSQMSHRLEP 1008
Query: 334 PSP 336
P
Sbjct: 1009 RRP 1011
>U78168-1|AAD12740.1| 881|Homo sapiens cAMP-regulated guanine
nucleotide exchange factor I protein.
Length = 881
Score = 88.6 bits (210), Expect = 5e-17
Identities = 55/166 (33%), Positives = 83/166 (50%), Gaps = 3/166 (1%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELT--TCGWTKLNKLTVAPNVVAFTKRFNRVSFWTV 159
+S D+ QLT D F +I EL G L +T A N+ F +RFN + +W
Sbjct: 619 VSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTA-NLERFMRRFNELQYWVA 677
Query: 160 QEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKK 219
E+ P RA+++ FIK+A L E N++S FAV+ L ++ I RL TW L K
Sbjct: 678 TELCLCPVPGPRAQLLKKFIKLAAHLKEQKNVNSFFAVMFGLSNSPISRLAHTWERLPHK 737
Query: 220 DKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYI 265
++ + L L + N R L +S P IP++ + L D+ +I
Sbjct: 738 VRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFI 783
>AY101396-1|AAM51551.1| 473|Homo sapiens Ral-GDS related protein
Rgr protein.
Length = 473
Score = 87.8 bits (208), Expect = 9e-17
Identities = 75/280 (26%), Positives = 125/280 (44%), Gaps = 25/280 (8%)
Query: 80 NSLPAACSINQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTK---LN 136
+S P S+ + + P + QLTL+D FK + E C W +
Sbjct: 196 SSCPCRGSVKNQPSEELPDMTTFPPRLLAEQLTLMDAELFKKVVLHECLGCIWGQGHLKG 255
Query: 137 KLTVAPNVVAFTKRFNRVSFWTVQEILNGQSPKAR--AEIMAHFIKVAKKLHELNNLHSL 194
+AP V A FNR++ L S +AR A ++ H+IKVA++ LNN S+
Sbjct: 256 NEHMAPTVRATIAHFNRLTNCITTSCLGDHSMRARDRARVVEHWIKVARECLSLNNFSSV 315
Query: 195 FAVISALHSASIYRLTKTWACLSKKDKQQFDKLA-----------------ELFGETDNW 237
++SAL S I +L KTWA +S K ++ +L ++ + N
Sbjct: 316 HVIVSALCSNPIGQLHKTWAGVSSKSMKELKELCKKDTAVKRDLLIKAGSFKVATQERNP 375
Query: 238 TALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPHRVTKMNIVLKALERYQSSEYEI 297
++ L+ +P+LG FLT+L +D A P K + ++ L+ Q ++
Sbjct: 376 QRVQMRLRRQKKGVVPFLGDFLTELQRLDSAIPDDLDGNTNKRSKEVRVLQEMQL--LQV 433
Query: 298 APLPHVANFLNS-VRYIEELQKFVEDDQYKLSLKLEPPSP 336
A + + L V Y +++ + + YKLS +LEP +P
Sbjct: 434 AAMNYRLRPLEKFVTYFTRMEQLSDKESYKLSCQLEPENP 473
>BC115375-1|AAI15376.1| 456|Homo sapiens Rap guanine nucleotide
exchange factor (GEF)-like 1 protein.
Length = 456
Score = 85.4 bits (202), Expect = 5e-16
Identities = 64/243 (26%), Positives = 110/243 (45%), Gaps = 11/243 (4%)
Query: 101 RLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQ 160
R+ P+DV N LT F+ + E + N+ +R + V+ W
Sbjct: 216 RVEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHWVAT 275
Query: 161 EILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKD 220
E+L ++P RA+++ FIK+A + +L S +AV+ L +A++ RL TW L K
Sbjct: 276 EVLLCEAPGKRAQLLKKFIKIAALCKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKF 335
Query: 221 KQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHP--AGSPHRVT 278
K F K L N + RE + + P IP++ + L DL ++ +
Sbjct: 336 KNLFRKFENLTDPCRNHKSYREVISKMKPPVIPFVPLILKDLTFLHEGSKTLVDGLVNIE 395
Query: 279 KMNIV---LKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQ---YKLSLKLE 332
K++ V ++ + +Y+S + N L + Y+ + Q V D+Q ++LS KLE
Sbjct: 396 KLHSVAEKVRTIRKYRSRPL-CLDMEASPNHLQTKAYVRQFQ--VIDNQNLLFELSYKLE 452
Query: 333 PPS 335
S
Sbjct: 453 ANS 455
>BC115374-1|AAI15375.1| 456|Homo sapiens Rap guanine nucleotide
exchange factor (GEF)-like 1 protein.
Length = 456
Score = 85.4 bits (202), Expect = 5e-16
Identities = 64/243 (26%), Positives = 110/243 (45%), Gaps = 11/243 (4%)
Query: 101 RLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQ 160
R+ P+DV N LT F+ + E + N+ +R + V+ W
Sbjct: 216 RVEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHWVAT 275
Query: 161 EILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKD 220
E+L ++P RA+++ FIK+A + +L S +AV+ L +A++ RL TW L K
Sbjct: 276 EVLLCEAPGKRAQLLKKFIKIAALCKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKF 335
Query: 221 KQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHP--AGSPHRVT 278
K F K L N + RE + + P IP++ + L DL ++ +
Sbjct: 336 KNLFRKFENLTDPCRNHKSYREVISKMKPPVIPFVPLILKDLTFLHEGSKTLVDGLVNIE 395
Query: 279 KMNIV---LKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQ---YKLSLKLE 332
K++ V ++ + +Y+S + N L + Y+ + Q V D+Q ++LS KLE
Sbjct: 396 KLHSVAEKVRTIRKYRSRPL-CLDMEASPNHLQTKAYVRQFQ--VIDNQNLLFELSYKLE 452
Query: 333 PPS 335
S
Sbjct: 453 ANS 455
>AF448437-1|AAL87858.1| 673|Homo sapiens guanyl nucleotide
releasing protein 4 protein.
Length = 673
Score = 85.4 bits (202), Expect = 5e-16
Identities = 65/238 (27%), Positives = 110/238 (46%), Gaps = 6/238 (2%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQE 161
L ++ LT L+ F+AI P++L + + + P + N VS W
Sbjct: 200 LETGELAQHLTYLEFRSFQAITPQDLRS--YVLQGSVRGCPALEGSVGLSNSVSRWVQVM 257
Query: 162 ILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDK 221
+L+ P RA+++ FI VA++LH+L N ++L AV L ++I RL + A LS
Sbjct: 258 VLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDST 317
Query: 222 QQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPH---RVT 278
+ +L EL +N+ R + +P LG+ L DLV + A P P +
Sbjct: 318 KALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLP 377
Query: 279 KMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEPPSP 336
K+N + L+ + + + P + L+ + +L + ED+ Y+LS EP P
Sbjct: 378 KLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDL-FYTEDEIYELSYAREPRCP 434
>AF117946-1|AAF22003.1| 456|Homo sapiens Link guanine nucleotide
exchange factor II protein.
Length = 456
Score = 85.4 bits (202), Expect = 5e-16
Identities = 64/243 (26%), Positives = 110/243 (45%), Gaps = 11/243 (4%)
Query: 101 RLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQ 160
R+ P+DV N LT F+ + E + N+ +R + V+ W
Sbjct: 216 RVEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHWVAT 275
Query: 161 EILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKD 220
E+L ++P RA+++ FIK+A + +L S +AV+ L +A++ RL TW L K
Sbjct: 276 EVLLCEAPGKRAQLLKKFIKIAALCKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKF 335
Query: 221 KQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHP--AGSPHRVT 278
K F K L N + RE + + P IP++ + L DL ++ +
Sbjct: 336 KNLFRKFENLTDPCRNHKSYREVISKMKPPVIPFVPLILKDLTFLHEGSKTLVDGLVNIE 395
Query: 279 KMNIV---LKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQ---YKLSLKLE 332
K++ V ++ + +Y+S + N L + Y+ + Q V D+Q ++LS KLE
Sbjct: 396 KLHSVAEKVRTIRKYRSRPL-CLDMEASPNHLQTKAYVRQFQ--VIDNQNLLFELSYKLE 452
Query: 333 PPS 335
S
Sbjct: 453 ANS 455
>D87467-1|BAA13406.2| 583|Homo sapiens KIAA0277 protein.
Length = 583
Score = 85.0 bits (201), Expect = 6e-16
Identities = 59/236 (25%), Positives = 117/236 (49%), Gaps = 13/236 (5%)
Query: 106 DVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNG 165
D+ +L D F +I +EL +++ N+ +R N V W EIL
Sbjct: 351 DLALELMNFDWSLFNSIHEQELIYFTFSRQGSGEHTANLSLLLQRCNEVQLWVATEILLC 410
Query: 166 QSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFD 225
R +++ FIK+A NL+S FA++ L++AS+ RL++TW + K K+ F
Sbjct: 411 SQLGKRVQLVKKFIKIAAHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFS 470
Query: 226 KLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPHRVT--KMNIV 283
+L L + N A R+ K + P IP++ + L D+ +I + + V K++++
Sbjct: 471 ELESLTDPSLNHKAYRDAFKKMKPPKIPFMPLLLKDVTFIHEGNKTFLDNLVNFEKLHMI 530
Query: 284 ---LKALERYQSSEY-EIAPLPH--VANFLNSVRYIEELQKFVEDDQYKLSLKLEP 333
++ L +++++ +++P H + +++N + I+ Q ++LS ++EP
Sbjct: 531 ADTVRTLRHCRTNQFGDLSPKEHQELKSYVNHLYVIDSQQAL-----FELSHRIEP 581
>AY048121-1|AAK85703.1| 659|Homo sapiens RAS guanyl releasing
protein 4 variant 2 protein.
Length = 659
Score = 85.0 bits (201), Expect = 6e-16
Identities = 65/238 (27%), Positives = 110/238 (46%), Gaps = 6/238 (2%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQE 161
L ++ LT L+ F+AI P++L + + + P + N VS W
Sbjct: 186 LETGELAQHLTYLEFRSFQAITPQDLRS--YVLQGSVRGCPALEGSVGLSNSVSRWVQVM 243
Query: 162 ILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDK 221
+L+ P RA+++ FI VA++LH+L N ++L AV L ++I RL + A LS
Sbjct: 244 VLSCPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDST 303
Query: 222 QQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPH---RVT 278
+ +L EL +N+ R + +P LG+ L DLV + A P P +
Sbjct: 304 KALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLP 363
Query: 279 KMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEPPSP 336
K+N + L+ + + + P + L+ + +L + ED+ Y+LS EP P
Sbjct: 364 KLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDL-FYTEDEIYELSYAREPRCP 420
>AY048119-1|AAK85701.1| 673|Homo sapiens RAS guanyl releasing
protein 4 protein.
Length = 673
Score = 85.0 bits (201), Expect = 6e-16
Identities = 65/238 (27%), Positives = 110/238 (46%), Gaps = 6/238 (2%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQE 161
L ++ LT L+ F+AI P++L + + + P + N VS W
Sbjct: 200 LETGELAQHLTYLEFRSFQAITPQDLRS--YVLQGSVRGCPALEGSVGLSNSVSRWVQVM 257
Query: 162 ILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDK 221
+L+ P RA+++ FI VA++LH+L N ++L AV L ++I RL + A LS
Sbjct: 258 VLSCPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDST 317
Query: 222 QQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPH---RVT 278
+ +L EL +N+ R + +P LG+ L DLV + A P P +
Sbjct: 318 KALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLP 377
Query: 279 KMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEPPSP 336
K+N + L+ + + + P + L+ + +L + ED+ Y+LS EP P
Sbjct: 378 KLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDL-FYTEDEIYELSYAREPRCP 434
>Y12336-1|CAA73005.1| 609|Homo sapiens F25B3.3 kinase like protein
protein.
Length = 609
Score = 81.8 bits (193), Expect = 6e-15
Identities = 76/241 (31%), Positives = 114/241 (47%), Gaps = 12/241 (4%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEE---LTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWT 158
L P ++ LT L+ F I ++ T G T N P + F FN VS W
Sbjct: 153 LEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCTVDN-----PVLERFISLFNSVSQWV 207
Query: 159 VQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSK 218
IL+ + RA ++ HF+ VA+KL +L N ++L AV+ L +SI RL +T + +S
Sbjct: 208 QLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSP 267
Query: 219 KDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPHRVT 278
+ + ++ L EL T N+ R L + P LG+ L DLV + +A P T
Sbjct: 268 ETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPILGVHLKDLVALQLALPDWLDPART 327
Query: 279 KMN-IVLKALERYQSSEYEIAPL--PHVAN-FLNSVRYIEELQKFVEDDQYKLSLKLEPP 334
++N +K L + L P AN L S+ + Q ED+ Y+LSL+ EP
Sbjct: 328 RLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQREPR 387
Query: 335 S 335
S
Sbjct: 388 S 388
>U78170-1|AAD12741.1| 609|Homo sapiens calcium- and
diacylglycerol-regulated guanine nucleotide exchange
factor I protein.
Length = 609
Score = 81.8 bits (193), Expect = 6e-15
Identities = 76/241 (31%), Positives = 114/241 (47%), Gaps = 12/241 (4%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEE---LTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWT 158
L P ++ LT L+ F I ++ T G T N P + F FN VS W
Sbjct: 153 LEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCTVDN-----PVLERFISLFNSVSQWV 207
Query: 159 VQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSK 218
IL+ + RA ++ HF+ VA+KL +L N ++L AV+ L +SI RL +T + +S
Sbjct: 208 QLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSP 267
Query: 219 KDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPHRVT 278
+ + ++ L EL T N+ R L + P LG+ L DLV + +A P T
Sbjct: 268 ETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPILGVHLKDLVALQLALPDWLDPART 327
Query: 279 KMN-IVLKALERYQSSEYEIAPL--PHVAN-FLNSVRYIEELQKFVEDDQYKLSLKLEPP 334
++N +K L + L P AN L S+ + Q ED+ Y+LSL+ EP
Sbjct: 328 RLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQREPR 387
Query: 335 S 335
S
Sbjct: 388 S 388
>BC117151-1|AAI17152.1| 609|Homo sapiens RAS guanyl releasing
protein 2 (calcium and DAG-regulated) protein.
Length = 609
Score = 81.8 bits (193), Expect = 6e-15
Identities = 76/241 (31%), Positives = 114/241 (47%), Gaps = 12/241 (4%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEE---LTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWT 158
L P ++ LT L+ F I ++ T G T N P + F FN VS W
Sbjct: 153 LEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCTVDN-----PVLERFISLFNSVSQWV 207
Query: 159 VQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSK 218
IL+ + RA ++ HF+ VA+KL +L N ++L AV+ L +SI RL +T + +S
Sbjct: 208 QLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSP 267
Query: 219 KDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPHRVT 278
+ + ++ L EL T N+ R L + P LG+ L DLV + +A P T
Sbjct: 268 ETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPILGVHLKDLVALQLALPDWLDPART 327
Query: 279 KMN-IVLKALERYQSSEYEIAPL--PHVAN-FLNSVRYIEELQKFVEDDQYKLSLKLEPP 334
++N +K L + L P AN L S+ + Q ED+ Y+LSL+ EP
Sbjct: 328 RLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQREPR 387
Query: 335 S 335
S
Sbjct: 388 S 388
>BC110306-1|AAI10307.1| 662|Homo sapiens RASGRP2 protein protein.
Length = 662
Score = 81.8 bits (193), Expect = 6e-15
Identities = 76/241 (31%), Positives = 114/241 (47%), Gaps = 12/241 (4%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEE---LTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWT 158
L P ++ LT L+ F I ++ T G T N P + F FN VS W
Sbjct: 206 LEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCTVDN-----PVLERFISLFNSVSQWV 260
Query: 159 VQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSK 218
IL+ + RA ++ HF+ VA+KL +L N ++L AV+ L +SI RL +T + +S
Sbjct: 261 QLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSP 320
Query: 219 KDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPHRVT 278
+ + ++ L EL T N+ R L + P LG+ L DLV + +A P T
Sbjct: 321 ETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPILGVHLKDLVALQLALPDWLDPART 380
Query: 279 KMN-IVLKALERYQSSEYEIAPL--PHVAN-FLNSVRYIEELQKFVEDDQYKLSLKLEPP 334
++N +K L + L P AN L S+ + Q ED+ Y+LSL+ EP
Sbjct: 381 RLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQREPR 440
Query: 335 S 335
S
Sbjct: 441 S 441
>AF081194-1|AAC79698.1| 609|Homo sapiens calcium and DAG-regulated
guanine nucleotide exchange factor I protein.
Length = 609
Score = 81.8 bits (193), Expect = 6e-15
Identities = 76/241 (31%), Positives = 114/241 (47%), Gaps = 12/241 (4%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEE---LTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWT 158
L P ++ LT L+ F I ++ T G T N P + F FN VS W
Sbjct: 153 LEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCTVDN-----PVLERFISLFNSVSQWV 207
Query: 159 VQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSK 218
IL+ + RA ++ HF+ VA+KL +L N ++L AV+ L +SI RL +T + +S
Sbjct: 208 QLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSP 267
Query: 219 KDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPHRVT 278
+ + ++ L EL T N+ R L + P LG+ L DLV + +A P T
Sbjct: 268 ETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPILGVHLKDLVALQLALPDWLDPART 327
Query: 279 KMN-IVLKALERYQSSEYEIAPL--PHVAN-FLNSVRYIEELQKFVEDDQYKLSLKLEPP 334
++N +K L + L P AN L S+ + Q ED+ Y+LSL+ EP
Sbjct: 328 RLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQREPR 387
Query: 335 S 335
S
Sbjct: 388 S 388
>AF043723-1|AAF07220.1| 609|Homo sapiens guanine exchange factor
MCG7 isoform 2 protein.
Length = 609
Score = 81.8 bits (193), Expect = 6e-15
Identities = 76/241 (31%), Positives = 114/241 (47%), Gaps = 12/241 (4%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEE---LTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWT 158
L P ++ LT L+ F I ++ T G T N P + F FN VS W
Sbjct: 153 LEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCTVDN-----PVLERFISLFNSVSQWV 207
Query: 159 VQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSK 218
IL+ + RA ++ HF+ VA+KL +L N ++L AV+ L +SI RL +T + +S
Sbjct: 208 QLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSP 267
Query: 219 KDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPHRVT 278
+ + ++ L EL T N+ R L + P LG+ L DLV + +A P T
Sbjct: 268 ETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPILGVHLKDLVALQLALPDWLDPART 327
Query: 279 KMN-IVLKALERYQSSEYEIAPL--PHVAN-FLNSVRYIEELQKFVEDDQYKLSLKLEPP 334
++N +K L + L P AN L S+ + Q ED+ Y+LSL+ EP
Sbjct: 328 RLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQREPR 387
Query: 335 S 335
S
Sbjct: 388 S 388
>AF043722-1|AAF07219.1| 671|Homo sapiens guanine exchange factor
MCG7 isoform 1 protein.
Length = 671
Score = 81.8 bits (193), Expect = 6e-15
Identities = 76/241 (31%), Positives = 114/241 (47%), Gaps = 12/241 (4%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEE---LTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWT 158
L P ++ LT L+ F I ++ T G T N P + F FN VS W
Sbjct: 215 LEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCTVDN-----PVLERFISLFNSVSQWV 269
Query: 159 VQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSK 218
IL+ + RA ++ HF+ VA+KL +L N ++L AV+ L +SI RL +T + +S
Sbjct: 270 QLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSP 329
Query: 219 KDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPHRVT 278
+ + ++ L EL T N+ R L + P LG+ L DLV + +A P T
Sbjct: 330 ETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPILGVHLKDLVALQLALPDWLDPART 389
Query: 279 KMN-IVLKALERYQSSEYEIAPL--PHVAN-FLNSVRYIEELQKFVEDDQYKLSLKLEPP 334
++N +K L + L P AN L S+ + Q ED+ Y+LSL+ EP
Sbjct: 390 RLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQREPR 449
Query: 335 S 335
S
Sbjct: 450 S 450
>Z97184-2|CAB09992.1| 777|Homo sapiens RAB2, member RAS oncogene
family-like protein.
Length = 777
Score = 76.2 bits (179), Expect = 3e-13
Identities = 75/275 (27%), Positives = 121/275 (44%), Gaps = 51/275 (18%)
Query: 105 DDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNK---LTVAPNVVAFTKRFNRVSFWTVQE 161
D + QLTLLD F + P + W ++ + P+V A +FN+V+ V
Sbjct: 245 DHLAEQLTLLDAELFLNLIPSQCLGGLWGHRDRPGHSHLCPSVRATVTQFNKVAGAVVSS 304
Query: 162 ILNGQS--------------PKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIY 207
+L S P RA ++ +I+VA++ L N S++AV+SAL S+ I+
Sbjct: 305 VLGATSTGEGPGEVTIRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPIH 364
Query: 208 RLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYL-KSISLP---------------- 250
RL W ++ + F L ++F E DN++ RE L + + L
Sbjct: 365 RLRAAWGEATRDSLRVFSSLCQIFSEEDNYSQSRELLVQEVKLQSPLEPHSKKAPRSGSR 424
Query: 251 ---CIPYLGIFLTDLVYIDIAHPAGSPH------RVTKMNIVLKALERYQSS--EYEIAP 299
+PYLG FL DLV +D A + + K VL L R Q+ Y + P
Sbjct: 425 GGGVVPYLGTFLKDLVMLDAASKDELENGYINFDKRRKEFAVLSELRRLQNECRGYNLQP 484
Query: 300 LPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEPP 334
+ +L +R + E Q +++S ++EPP
Sbjct: 485 DHDIQRWLQGLRPLTEAQ------SHRVSCEVEPP 513
>BX000343-5|CAI41832.1| 777|Homo sapiens ral guanine nucleotide
dissociation stimulator-like 2 protein.
Length = 777
Score = 76.2 bits (179), Expect = 3e-13
Identities = 75/275 (27%), Positives = 121/275 (44%), Gaps = 51/275 (18%)
Query: 105 DDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNK---LTVAPNVVAFTKRFNRVSFWTVQE 161
D + QLTLLD F + P + W ++ + P+V A +FN+V+ V
Sbjct: 245 DHLAEQLTLLDAELFLNLIPSQCLGGLWGHRDRPGHSHLCPSVRATVTQFNKVAGAVVSS 304
Query: 162 ILNGQS--------------PKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIY 207
+L S P RA ++ +I+VA++ L N S++AV+SAL S+ I+
Sbjct: 305 VLGATSTGEGPGEVTIRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPIH 364
Query: 208 RLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYL-KSISLP---------------- 250
RL W ++ + F L ++F E DN++ RE L + + L
Sbjct: 365 RLRAAWGEATRDSLRVFSSLCQIFSEEDNYSQSRELLVQEVKLQSPLEPHSKKAPRSGSR 424
Query: 251 ---CIPYLGIFLTDLVYIDIAHPAGSPH------RVTKMNIVLKALERYQSS--EYEIAP 299
+PYLG FL DLV +D A + + K VL L R Q+ Y + P
Sbjct: 425 GGGVVPYLGTFLKDLVMLDAASKDELENGYINFDKRRKEFAVLSELRRLQNECRGYNLQP 484
Query: 300 LPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEPP 334
+ +L +R + E Q +++S ++EPP
Sbjct: 485 DHDIQRWLQGLRPLTEAQ------SHRVSCEVEPP 513
>BC032681-1|AAH32681.1| 777|Homo sapiens ral guanine nucleotide
dissociation stimulator-like 2 protein.
Length = 777
Score = 76.2 bits (179), Expect = 3e-13
Identities = 75/275 (27%), Positives = 121/275 (44%), Gaps = 51/275 (18%)
Query: 105 DDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNK---LTVAPNVVAFTKRFNRVSFWTVQE 161
D + QLTLLD F + P + W ++ + P+V A +FN+V+ V
Sbjct: 245 DHLAEQLTLLDAELFLNLIPSQCLGGLWGHRDRPGHSHLCPSVRATVTQFNKVAGAVVSS 304
Query: 162 ILNGQS--------------PKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIY 207
+L S P RA ++ +I+VA++ L N S++AV+SAL S+ I+
Sbjct: 305 VLGATSTGEGPGEVTIRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPIH 364
Query: 208 RLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYL-KSISLP---------------- 250
RL W ++ + F L ++F E DN++ RE L + + L
Sbjct: 365 RLRAAWGEATRDSLRVFSSLCQIFSEEDNYSQSRELLVQEVKLQSPLEPHSKKAPRSGSR 424
Query: 251 ---CIPYLGIFLTDLVYIDIAHPAGSPH------RVTKMNIVLKALERYQSS--EYEIAP 299
+PYLG FL DLV +D A + + K VL L R Q+ Y + P
Sbjct: 425 GGGVVPYLGTFLKDLVMLDAASKDELENGYINFDKRRKEFAVLSELRRLQNECRGYNLQP 484
Query: 300 LPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEPP 334
+ +L +R + E Q +++S ++EPP
Sbjct: 485 DHDIQRWLQGLRPLTEAQ------SHRVSCEVEPP 513
>BC005037-1|AAH05037.1| 644|Homo sapiens RGL2 protein protein.
Length = 644
Score = 76.2 bits (179), Expect = 3e-13
Identities = 75/275 (27%), Positives = 121/275 (44%), Gaps = 51/275 (18%)
Query: 105 DDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNK---LTVAPNVVAFTKRFNRVSFWTVQE 161
D + QLTLLD F + P + W ++ + P+V A +FN+V+ V
Sbjct: 112 DHLAEQLTLLDAELFLNLIPSQCLGGLWGHRDRPGHSHLCPSVRATVTQFNKVAGAVVSS 171
Query: 162 ILNGQS--------------PKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIY 207
+L S P RA ++ +I+VA++ L N S++AV+SAL S+ I+
Sbjct: 172 VLGATSTGEGPGEVTIRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPIH 231
Query: 208 RLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYL-KSISLP---------------- 250
RL W ++ + F L ++F E DN++ RE L + + L
Sbjct: 232 RLRAAWGEATRDSLRVFSSLCQIFSEEDNYSQSRELLVQEVKLQSPLEPHSKKAPRSGSR 291
Query: 251 ---CIPYLGIFLTDLVYIDIAHPAGSPH------RVTKMNIVLKALERYQSS--EYEIAP 299
+PYLG FL DLV +D A + + K VL L R Q+ Y + P
Sbjct: 292 GGGVVPYLGTFLKDLVMLDAASKDELENGYINFDKRRKEFAVLSELRRLQNECRGYNLQP 351
Query: 300 LPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEPP 334
+ +L +R + E Q +++S ++EPP
Sbjct: 352 DHDIQRWLQGLRPLTEAQ------SHRVSCEVEPP 380
>AL662827-6|CAI17521.1| 777|Homo sapiens ral guanine nucleotide
dissociation stimulator-like 2 protein.
Length = 777
Score = 76.2 bits (179), Expect = 3e-13
Identities = 75/275 (27%), Positives = 121/275 (44%), Gaps = 51/275 (18%)
Query: 105 DDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNK---LTVAPNVVAFTKRFNRVSFWTVQE 161
D + QLTLLD F + P + W ++ + P+V A +FN+V+ V
Sbjct: 245 DHLAEQLTLLDAELFLNLIPSQCLGGLWGHRDRPGHSHLCPSVRATVTQFNKVAGAVVSS 304
Query: 162 ILNGQS--------------PKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIY 207
+L S P RA ++ +I+VA++ L N S++AV+SAL S+ I+
Sbjct: 305 VLGATSTGEGPGEVTIRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPIH 364
Query: 208 RLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYL-KSISLP---------------- 250
RL W ++ + F L ++F E DN++ RE L + + L
Sbjct: 365 RLRAAWGEATRDSLRVFSSLCQIFSEEDNYSQSRELLVQEVKLQSPLEPHSKKAPRSGSR 424
Query: 251 ---CIPYLGIFLTDLVYIDIAHPAGSPH------RVTKMNIVLKALERYQSS--EYEIAP 299
+PYLG FL DLV +D A + + K VL L R Q+ Y + P
Sbjct: 425 GGGVVPYLGTFLKDLVMLDAASKDELENGYINFDKRRKEFAVLSELRRLQNECRGYNLQP 484
Query: 300 LPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEPP 334
+ +L +R + E Q +++S ++EPP
Sbjct: 485 DHDIQRWLQGLRPLTEAQ------SHRVSCEVEPP 513
>AL662820-6|CAI18118.1| 777|Homo sapiens ral guanine nucleotide
dissociation stimulator-like 2 protein.
Length = 777
Score = 76.2 bits (179), Expect = 3e-13
Identities = 75/275 (27%), Positives = 121/275 (44%), Gaps = 51/275 (18%)
Query: 105 DDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNK---LTVAPNVVAFTKRFNRVSFWTVQE 161
D + QLTLLD F + P + W ++ + P+V A +FN+V+ V
Sbjct: 245 DHLAEQLTLLDAELFLNLIPSQCLGGLWGHRDRPGHSHLCPSVRATVTQFNKVAGAVVSS 304
Query: 162 ILNGQS--------------PKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIY 207
+L S P RA ++ +I+VA++ L N S++AV+SAL S+ I+
Sbjct: 305 VLGATSTGEGPGEVTIRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPIH 364
Query: 208 RLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYL-KSISLP---------------- 250
RL W ++ + F L ++F E DN++ RE L + + L
Sbjct: 365 RLRAAWGEATRDSLRVFSSLCQIFSEEDNYSQSRELLVQEVKLQSPLEPHSKKAPRSGSR 424
Query: 251 ---CIPYLGIFLTDLVYIDIAHPAGSPH------RVTKMNIVLKALERYQSS--EYEIAP 299
+PYLG FL DLV +D A + + K VL L R Q+ Y + P
Sbjct: 425 GGGVVPYLGTFLKDLVMLDAASKDELENGYINFDKRRKEFAVLSELRRLQNECRGYNLQP 484
Query: 300 LPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEPP 334
+ +L +R + E Q +++S ++EPP
Sbjct: 485 DHDIQRWLQGLRPLTEAQ------SHRVSCEVEPP 513
>AF081197-1|AAF21898.1| 782|Homo sapiens calcium and DAG-regulated
guanine nucleotide exchange factor II protein.
Length = 782
Score = 76.2 bits (179), Expect = 3e-13
Identities = 60/235 (25%), Positives = 107/235 (45%), Gaps = 6/235 (2%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQE 161
L P+++ LT L+ F+ I + + + + P + N +S W
Sbjct: 189 LEPEELSEHLTYLEFKSFRRISFSDYQN--YLVNSCVKENPTMERSIALCNGISQWVQLM 246
Query: 162 ILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDK 221
+L+ +P+ RAE+ FI+VA+KLH+L N ++L AVI L +SI RL +T + + +
Sbjct: 247 VLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEIN 306
Query: 222 QQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHP---AGSPHRVT 278
+ ++ EL + N+ R + IP LG+ L DL+ + A P V
Sbjct: 307 KVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLGDGKVNVH 366
Query: 279 KMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEP 333
K+ + + + PL + ++ + +L + ED+ Y+LS EP
Sbjct: 367 KLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLY-YTEDEIYELSYAREP 420
>AF081195-1|AAC79699.1| 797|Homo sapiens calcium and DAG-regulated
guanine nucleotide exchange factor II protein.
Length = 797
Score = 76.2 bits (179), Expect = 3e-13
Identities = 60/235 (25%), Positives = 107/235 (45%), Gaps = 6/235 (2%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQE 161
L P+++ LT L+ F+ I + + + + P + N +S W
Sbjct: 204 LEPEELSEHLTYLEFKSFRRISFSDYQN--YLVNSCVKENPTMERSIALCNGISQWVQLM 261
Query: 162 ILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDK 221
+L+ +P+ RAE+ FI+VA+KLH+L N ++L AVI L +SI RL +T + + +
Sbjct: 262 VLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEIN 321
Query: 222 QQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHP---AGSPHRVT 278
+ ++ EL + N+ R + IP LG+ L DL+ + A P V
Sbjct: 322 KVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLGDGKVNVH 381
Query: 279 KMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEP 333
K+ + + + PL + ++ + +L + ED+ Y+LS EP
Sbjct: 382 KLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLY-YTEDEIYELSYAREP 435
>BC109297-1|AAI09298.1| 797|Homo sapiens RAS guanyl releasing
protein 1 (calcium and DAG-regulated) protein.
Length = 797
Score = 75.8 bits (178), Expect = 4e-13
Identities = 60/235 (25%), Positives = 107/235 (45%), Gaps = 6/235 (2%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQE 161
L P+++ LT L+ F+ I + + + + P + N +S W
Sbjct: 204 LEPEELSEHLTYLEFKSFRRISFSDYQN--YLVNSCVKENPTMERSIALCNGISQWVQLM 261
Query: 162 ILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDK 221
+L+ +P+ RAE+ FI+VA+KLH+L N ++L AVI L +SI RL +T + + +
Sbjct: 262 VLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEIN 321
Query: 222 QQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHP---AGSPHRVT 278
+ ++ EL + N+ R + IP LG+ L DL+ + A P V
Sbjct: 322 KVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKVNVH 381
Query: 279 KMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEP 333
K+ + + + PL + ++ + +L + ED+ Y+LS EP
Sbjct: 382 KLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLY-YTEDEIYELSYAREP 435
>BC109296-1|AAI09297.1| 797|Homo sapiens RAS guanyl releasing
protein 1 (calcium and DAG-regulated) protein.
Length = 797
Score = 75.8 bits (178), Expect = 4e-13
Identities = 60/235 (25%), Positives = 107/235 (45%), Gaps = 6/235 (2%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQE 161
L P+++ LT L+ F+ I + + + + P + N +S W
Sbjct: 204 LEPEELSEHLTYLEFKSFRRISFSDYQN--YLVNSCVKENPTMERSIALCNGISQWVQLM 261
Query: 162 ILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDK 221
+L+ +P+ RAE+ FI+VA+KLH+L N ++L AVI L +SI RL +T + + +
Sbjct: 262 VLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEIN 321
Query: 222 QQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHP---AGSPHRVT 278
+ ++ EL + N+ R + IP LG+ L DL+ + A P V
Sbjct: 322 KVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKVNVH 381
Query: 279 KMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEP 333
K+ + + + PL + ++ + +L + ED+ Y+LS EP
Sbjct: 382 KLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLY-YTEDEIYELSYAREP 435
>BC067298-1|AAH67298.1| 765|Homo sapiens RASGRP1 protein protein.
Length = 765
Score = 75.8 bits (178), Expect = 4e-13
Identities = 60/235 (25%), Positives = 107/235 (45%), Gaps = 6/235 (2%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQE 161
L P+++ LT L+ F+ I + + + + P + N +S W
Sbjct: 204 LEPEELSEHLTYLEFKSFRRISFSDYQN--YLVNSCVKENPTMERSIALCNGISQWVQLM 261
Query: 162 ILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDK 221
+L+ +P+ RAE+ FI+VA+KLH+L N ++L AVI L +SI RL +T + + +
Sbjct: 262 VLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEIN 321
Query: 222 QQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHP---AGSPHRVT 278
+ ++ EL + N+ R + IP LG+ L DL+ + A P V
Sbjct: 322 KVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKVNVH 381
Query: 279 KMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEP 333
K+ + + + PL + ++ + +L + ED+ Y+LS EP
Sbjct: 382 KLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLY-YTEDEIYELSYAREP 435
>AY966005-1|AAX76907.1| 481|Homo sapiens RAS guanyl releasing
protein I splice variant C protein.
Length = 481
Score = 75.8 bits (178), Expect = 4e-13
Identities = 60/235 (25%), Positives = 107/235 (45%), Gaps = 6/235 (2%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQE 161
L P+++ LT L+ F+ I + + + + P + N +S W
Sbjct: 204 LEPEELSEHLTYLEFKSFRRISFSDYQN--YLVNSCVKENPTMERSIALCNGISQWVQLM 261
Query: 162 ILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDK 221
+L+ +P+ RAE+ FI+VA+KLH+L N ++L AVI L +SI RL +T + + +
Sbjct: 262 VLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEIN 321
Query: 222 QQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHP---AGSPHRVT 278
+ ++ EL + N+ R + IP LG+ L DL+ + A P V
Sbjct: 322 KVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKVNVH 381
Query: 279 KMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEP 333
K+ + + + PL + ++ + +L + ED+ Y+LS EP
Sbjct: 382 KLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLY-YTEDEIYELSYAREP 435
>AY954625-1|AAX54699.4| 762|Homo sapiens Ras guanyl releasing
protein I splice variant A protein.
Length = 762
Score = 75.8 bits (178), Expect = 4e-13
Identities = 60/235 (25%), Positives = 107/235 (45%), Gaps = 6/235 (2%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQE 161
L P+++ LT L+ F+ I + + + + P + N +S W
Sbjct: 204 LEPEELSEHLTYLEFKSFRRISFSDYQN--YLVNSCVKENPTMERSIALCNGISQWVQLM 261
Query: 162 ILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDK 221
+L+ +P+ RAE+ FI+VA+KLH+L N ++L AVI L +SI RL +T + + +
Sbjct: 262 VLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEIN 321
Query: 222 QQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHP---AGSPHRVT 278
+ ++ EL + N+ R + IP LG+ L DL+ + A P V
Sbjct: 322 KVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKVNVH 381
Query: 279 KMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEP 333
K+ + + + PL + ++ + +L + ED+ Y+LS EP
Sbjct: 382 KLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLY-YTEDEIYELSYAREP 435
>AY858556-1|AAW32406.2| 597|Homo sapiens RAS guanyl releasing
protein I splice variant B protein.
Length = 597
Score = 75.8 bits (178), Expect = 4e-13
Identities = 60/235 (25%), Positives = 107/235 (45%), Gaps = 6/235 (2%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQE 161
L P+++ LT L+ F+ I + + + + P + N +S W
Sbjct: 204 LEPEELSEHLTYLEFKSFRRISFSDYQN--YLVNSCVKENPTMERSIALCNGISQWVQLM 261
Query: 162 ILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDK 221
+L+ +P+ RAE+ FI+VA+KLH+L N ++L AVI L +SI RL +T + + +
Sbjct: 262 VLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEIN 321
Query: 222 QQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHP---AGSPHRVT 278
+ ++ EL + N+ R + IP LG+ L DL+ + A P V
Sbjct: 322 KVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKVNVH 381
Query: 279 KMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEP 333
K+ + + + PL + ++ + +L + ED+ Y+LS EP
Sbjct: 382 KLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLY-YTEDEIYELSYAREP 435
>AY634315-1|AAT47482.2| 546|Homo sapiens Ras guanyl releasing
protein I splice variant D protein.
Length = 546
Score = 75.8 bits (178), Expect = 4e-13
Identities = 60/235 (25%), Positives = 107/235 (45%), Gaps = 6/235 (2%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQE 161
L P+++ LT L+ F+ I + + + + P + N +S W
Sbjct: 204 LEPEELSEHLTYLEFKSFRRISFSDYQN--YLVNSCVKENPTMERSIALCNGISQWVQLM 261
Query: 162 ILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDK 221
+L+ +P+ RAE+ FI+VA+KLH+L N ++L AVI L +SI RL +T + + +
Sbjct: 262 VLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEIN 321
Query: 222 QQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHP---AGSPHRVT 278
+ ++ EL + N+ R + IP LG+ L DL+ + A P V
Sbjct: 322 KVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKVNVH 381
Query: 279 KMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEP 333
K+ + + + PL + ++ + +L + ED+ Y+LS EP
Sbjct: 382 KLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLY-YTEDEIYELSYAREP 435
>AF106071-1|AAC97349.1| 797|Homo sapiens ras activator RasGRP
protein.
Length = 797
Score = 75.8 bits (178), Expect = 4e-13
Identities = 60/235 (25%), Positives = 107/235 (45%), Gaps = 6/235 (2%)
Query: 102 LSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQE 161
L P+++ LT L+ F+ I + + + + P + N +S W
Sbjct: 204 LEPEELSEHLTYLEFKSFRRISFSDYQN--YLVNSCVKENPTMERSIALCNGISQWVQLM 261
Query: 162 ILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDK 221
+L+ +P+ RAE+ FI+VA+KLH+L N ++L AVI L +SI RL +T + + +
Sbjct: 262 VLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEIN 321
Query: 222 QQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHP---AGSPHRVT 278
+ ++ EL + N+ R + IP LG+ L DL+ + A P V
Sbjct: 322 KVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKVNVH 381
Query: 279 KMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEP 333
K+ + + + PL + ++ + +L + ED+ Y+LS EP
Sbjct: 382 KLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLY-YTEDEIYELSYAREP 435
>BC101110-1|AAI01111.2| 536|Homo sapiens Rgr protein protein.
Length = 536
Score = 74.5 bits (175), Expect = 9e-13
Identities = 68/267 (25%), Positives = 118/267 (44%), Gaps = 27/267 (10%)
Query: 80 NSLPAACSINQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTK---LN 136
+S P S+ + + P + QLTL+D FK + E C W +
Sbjct: 196 SSCPCRGSVKNQPSEELPDMTTFPPRLLAEQLTLMDAELFKKVVLYECLGCIWGQGHLKG 255
Query: 137 KLTVAPNVVAFTKRFNRVSFWTVQEILNGQSPKAR--AEIMAHFIKVAKKLHELNNLHSL 194
+AP V A FNR++ L S +AR A ++ H+IKVA++ LNN S+
Sbjct: 256 NEHMAPTVRATIAHFNRLTNCITTSCLGDHSMRARDRARVVEHWIKVARECLSLNNFSSV 315
Query: 195 FAVISALHSASIYRLTKTWACLSKKDKQQFDKLA-----------------ELFGETDNW 237
++SAL S I +L KTWA +S K ++ +L ++ + N
Sbjct: 316 HVIVSALCSNPIGQLHKTWAGVSSKSMKELKELCKKDTAVKRDLLIKAGSFKVATQERNP 375
Query: 238 TALREYLKSISLPCIPYLGIFLTDLVYIDIAHP---AGSPHRVTKMNIVLKALERYQ--S 292
+ L+ +P+LG FLT+L +D A P G+ ++ +K VL+ ++ Q +
Sbjct: 376 QRAQMRLRRQKKGVVPFLGDFLTELQRLDSAIPDDLDGNTNKRSKEVRVLQEMQLLQVAA 435
Query: 293 SEYEIAPLPHVANFLNSVRYIEELQKF 319
Y + PL + + + + +++
Sbjct: 436 MNYRLRPLEKFVTYFTRMEQLSDKERW 462
>BC101108-1|AAI01109.1| 356|Homo sapiens Rgr protein protein.
Length = 356
Score = 74.5 bits (175), Expect = 9e-13
Identities = 68/267 (25%), Positives = 118/267 (44%), Gaps = 27/267 (10%)
Query: 80 NSLPAACSINQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTK---LN 136
+S P S+ + + P + QLTL+D FK + E C W +
Sbjct: 60 SSCPCRGSVKNQPSEELPDMTTFPPRLLAEQLTLMDAELFKKVVLYECLGCIWGQGHLKG 119
Query: 137 KLTVAPNVVAFTKRFNRVSFWTVQEILNGQSPKAR--AEIMAHFIKVAKKLHELNNLHSL 194
+AP V A FNR++ L S +AR A ++ H+IKVA++ LNN S+
Sbjct: 120 NEHMAPTVRATIAHFNRLTNCITTSCLGDHSMRARDRARVVEHWIKVARECLSLNNFSSV 179
Query: 195 FAVISALHSASIYRLTKTWACLSKKDKQQFDKLA-----------------ELFGETDNW 237
++SAL S I +L KTWA +S K ++ +L ++ + N
Sbjct: 180 HVIVSALCSNPIGQLHKTWAGVSSKSMKELKELCKKDTAVKRDLLIKAGSFKVATQERNP 239
Query: 238 TALREYLKSISLPCIPYLGIFLTDLVYIDIAHP---AGSPHRVTKMNIVLKALERYQ--S 292
+ L+ +P+LG FLT+L +D A P G+ ++ +K VL+ ++ Q +
Sbjct: 240 QRAQMRLRRQKKGVVPFLGDFLTELQRLDSAIPDDLDGNTNKRSKEVRVLQEMQLLQVAA 299
Query: 293 SEYEIAPLPHVANFLNSVRYIEELQKF 319
Y + PL + + + + +++
Sbjct: 300 MNYRLRPLEKFVTYFTRMEQLSDKERW 326
>BC101109-1|AAI01110.1| 410|Homo sapiens Rgr protein protein.
Length = 410
Score = 74.1 bits (174), Expect = 1e-12
Identities = 68/266 (25%), Positives = 117/266 (43%), Gaps = 27/266 (10%)
Query: 80 NSLPAACSINQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTK---LN 136
+S P S+ + + P + QLTL+D FK + E C W +
Sbjct: 60 SSCPCRGSVKNQPSEELPDMTTFPPRLLAEQLTLMDAELFKKVVLYECLGCIWGQGHLKG 119
Query: 137 KLTVAPNVVAFTKRFNRVSFWTVQEILNGQSPKAR--AEIMAHFIKVAKKLHELNNLHSL 194
+AP V A FNR++ L S +AR A ++ H+IKVA++ LNN S+
Sbjct: 120 NEHMAPTVRATIAHFNRLTNCITTSCLGDHSMRARDRARVVEHWIKVARECLSLNNFSSV 179
Query: 195 FAVISALHSASIYRLTKTWACLSKKDKQQFDKLA-----------------ELFGETDNW 237
++SAL S I +L KTWA +S K ++ +L ++ + N
Sbjct: 180 HVIVSALCSNPIGQLHKTWAGVSSKSMKELKELCKKDTAVKRDLLIKAGSFKVATQERNP 239
Query: 238 TALREYLKSISLPCIPYLGIFLTDLVYIDIAHP---AGSPHRVTKMNIVLKALERYQ--S 292
+ L+ +P+LG FLT+L +D A P G+ ++ +K VL+ ++ Q +
Sbjct: 240 QRAQMRLRRQKKGVVPFLGDFLTELQRLDSAIPDDLDGNTNKRSKEVRVLQEMQLLQVAA 299
Query: 293 SEYEIAPLPHVANFLNSVRYIEELQK 318
Y + PL + + + + ++
Sbjct: 300 MNYRLRPLEKFVTYFTRMEQLSDKER 325
>BC040275-1|AAH40275.1| 1181|Homo sapiens RASGRF1 protein protein.
Length = 1181
Score = 74.1 bits (174), Expect = 1e-12
Identities = 39/114 (34%), Positives = 62/114 (54%)
Query: 106 DVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNG 165
++ QLTLLD FK I EE GW KL K P ++ TK FN +S EI+
Sbjct: 1025 EIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEIIRN 1084
Query: 166 QSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKK 219
+ AR + ++ VA L+N +++ + S+++ ++I+RL KTW +SK+
Sbjct: 1085 EDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQ 1138
>AB208848-1|BAD92085.1| 530|Homo sapiens Ras activator RasGRP
variant protein.
Length = 530
Score = 72.1 bits (169), Expect = 5e-12
Identities = 52/185 (28%), Positives = 89/185 (48%), Gaps = 4/185 (2%)
Query: 152 NRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTK 211
N +S W +L+ +P+ RAE+ FI+VA+KLH+L N ++L AVI L +SI RL +
Sbjct: 20 NGISQWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKE 79
Query: 212 TWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHP- 270
T + + + + ++ EL + N+ R + IP LG+ L DL+ + A P
Sbjct: 80 TSSHVPHEINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPD 139
Query: 271 --AGSPHRVTKMNIVLKALERYQSSEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLS 328
V K+ + + + PL + ++ + +L + ED+ Y+LS
Sbjct: 140 YLEDGKVNVHKLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLY-YTEDEIYELS 198
Query: 329 LKLEP 333
EP
Sbjct: 199 YAREP 203
>AK131340-1|BAD18497.1| 435|Homo sapiens protein ( Homo sapiens
cDNA FLJ16354 fis, clone TESTI4000319, weakly similar
to GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR RALGDS
FORM B. ).
Length = 435
Score = 70.5 bits (165), Expect = 1e-11
Identities = 48/155 (30%), Positives = 74/155 (47%), Gaps = 5/155 (3%)
Query: 80 NSLPAACSINQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTK---LN 136
+S P S+ + + P + QLTL+D FK + E C W +
Sbjct: 196 SSCPCRGSVKNQPSEELPDMTTFPPRLLAEQLTLMDAELFKKVVLYECLGCIWGQGHLKG 255
Query: 137 KLTVAPNVVAFTKRFNRVSFWTVQEILNGQSPKAR--AEIMAHFIKVAKKLHELNNLHSL 194
+AP V A FNR++ L S +AR A ++ H+IKVA++ LNN S+
Sbjct: 256 NEHMAPTVRATIAHFNRLTNCITTSCLGDHSMRARDRARVVEHWIKVARECLSLNNFSSV 315
Query: 195 FAVISALHSASIYRLTKTWACLSKKDKQQFDKLAE 229
++SAL S I +L KTWA +S K ++ +L +
Sbjct: 316 HVIVSALCSNPIGQLHKTWAGVSSKSMKELKELCK 350
>BC039203-1|AAH39203.1| 444|Homo sapiens RAPGEF5 protein protein.
Length = 444
Score = 70.1 bits (164), Expect = 2e-11
Identities = 48/182 (26%), Positives = 97/182 (53%), Gaps = 13/182 (7%)
Query: 160 QEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKK 219
QEIL R +++ FIK+A NL+S FA++ L++AS+ RL++TW + K
Sbjct: 266 QEILLCSQLGKRVQLVKKFIKIAAHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPGK 325
Query: 220 DKQQFDKLAELFGETDNWTALREYLKSISLPCIPYLGIFLTDLVYIDIAHPAGSPHRVT- 278
K+ F +L L + N A R+ K + P IP++ + L D+ +I + + V
Sbjct: 326 FKKLFSELESLTDPSLNHKAYRDAFKKMKPPKIPFVPLLLKDVTFIHEGNKTFLDNLVNF 385
Query: 279 -KMNIV---LKALERYQSSEY-EIAPLPH--VANFLNSVRYIEELQKFVEDDQYKLSLKL 331
K++++ ++ L +++++ +++P H + +++N + I+ Q ++LS ++
Sbjct: 386 EKLHMIADTVRTLRHCRTNQFGDLSPKEHQELKSYVNHLYVIDSQQAL-----FELSHRI 440
Query: 332 EP 333
EP
Sbjct: 441 EP 442
>BC000316-1|AAH00316.1| 516|Homo sapiens RGL2 protein protein.
Length = 516
Score = 68.1 bits (159), Expect = 8e-11
Identities = 65/237 (27%), Positives = 106/237 (44%), Gaps = 48/237 (20%)
Query: 140 VAPNVVAFTKRFNRVSFWTVQEILNGQS--------------PKARAEIMAHFIKVAKKL 185
+ P+V A +FN+V+ V +L S P RA ++ +I+VA++
Sbjct: 22 LCPSVRATVTQFNKVAGAVVSSVLGATSTGEGPGEVTIRPLRPPQRARLLEKWIRVAEEC 81
Query: 186 HELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYL- 244
L N S++AV+SAL S+ I+RL W ++ + F L ++F E DN++ RE L
Sbjct: 82 RLLRNFSSVYAVVSALQSSPIHRLRAAWGEATRDSLRVFSSLCQIFSEEDNYSQSRELLV 141
Query: 245 KSISLP-------------------CIPYLGIFLTDLVYIDIAHPAGSPH------RVTK 279
+ + L +PYLG FL DLV +D A + + K
Sbjct: 142 QEVKLQSPLEPHSKKAPRSGSRGGGVVPYLGTFLKDLVMLDAASKDELENGYINFDKRRK 201
Query: 280 MNIVLKALERYQSS--EYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEPP 334
VL L R Q+ Y + P + +L +R + E Q +++S ++EPP
Sbjct: 202 EFAVLSELRRLQNECRGYNLQPDHDIQRWLQGLRPLTEAQ------SHRVSCEVEPP 252
>U68142-1|AAC50818.1| 518|Homo sapiens RalGDS-like protein.
Length = 518
Score = 67.3 bits (157), Expect = 1e-10
Identities = 56/195 (28%), Positives = 91/195 (46%), Gaps = 34/195 (17%)
Query: 168 PKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFDKL 227
P RA ++ +I+VA++ L N S++AV+SAL S+ I+RL W ++ + F L
Sbjct: 47 PPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPIHRLRAAWGEATRDSLRVFSSL 106
Query: 228 AELFGETDNWTALREYL-KSISLP-------------------CIPYLGIFLTDLVYIDI 267
++F E DN++ RE L + + L +PYLG FL DLV +D
Sbjct: 107 CQIFSEEDNYSQSRELLVQEVKLQSPLEPHSKKAPRSGSRGGGVVPYLGTFLKDLVMLDA 166
Query: 268 AHPAGSPH------RVTKMNIVLKALERYQSS--EYEIAPLPHVANFLNSVRYIEELQKF 319
A + + K VL L R Q+ Y + P + +L +R + E Q
Sbjct: 167 ASKDELENGYINFDKRRKEFAVLSELRRLQNECRGYNLQPDHDIQRWLQGLRPLTEAQ-- 224
Query: 320 VEDDQYKLSLKLEPP 334
+++S ++EPP
Sbjct: 225 ----SHRVSCEVEPP 235
>AL162417-9|CAI13414.1| 309|Homo sapiens ral guanine nucleotide
dissociation stimulator protein.
Length = 309
Score = 64.5 bits (150), Expect = 1e-09
Identities = 59/184 (32%), Positives = 85/184 (46%), Gaps = 38/184 (20%)
Query: 188 LNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYL--- 244
L N SL+A++SAL S SI+RL KTW +S+ + F KL+E+F + +N++ RE L
Sbjct: 36 LKNFSSLYAILSALQSNSIHRLKKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKE 95
Query: 245 ---------------------KSISLPCIPYLGIFLTDLVYIDIAHPAGSPHRV------ 277
I +PYLG FLTDLV +D A R+
Sbjct: 96 GTSKFATLEMNPKRAQKRPKETGIIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKR 155
Query: 278 TKMNIVLKALERYQS--SEYEIAPLPHVANFLNSVRYIEELQKFVEDDQYKLSLKLEPPS 335
K V+ ++ QS + Y IAP + +V ++ E + Y LS +LEPPS
Sbjct: 156 RKEFEVIAQIKLLQSACNNYSIAPDEQFGAWFRAV------ERLSETESYNLSCELEPPS 209
Query: 336 PVGS 339
S
Sbjct: 210 ESAS 213
>BC057759-1|AAH57759.1| 238|Homo sapiens RasGEF domain family,
member 1C protein.
Length = 238
Score = 62.9 bits (146), Expect = 3e-09
Identities = 38/118 (32%), Positives = 59/118 (50%), Gaps = 7/118 (5%)
Query: 104 PDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAP-------NVVAFTKRFNRVSF 156
P + QLT ++L + I PEE K + P N+ A+ K FNR+ +
Sbjct: 50 PYTLAQQLTHVELERLRHIGPEEFVQAFVNKDPLASTKPCFSDKTSNLEAYVKWFNRLCY 109
Query: 157 WTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWA 214
EI K RA+++ FI VA++ + N +SL A+IS ++ + + RL KTWA
Sbjct: 110 LVATEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWA 167
>BC036802-1|AAH36802.1| 508|Homo sapiens RASGEF1C protein protein.
Length = 508
Score = 62.9 bits (146), Expect = 3e-09
Identities = 38/118 (32%), Positives = 59/118 (50%), Gaps = 7/118 (5%)
Query: 104 PDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAP-------NVVAFTKRFNRVSF 156
P + QLT ++L + I PEE K + P N+ A+ K FNR+ +
Sbjct: 243 PYTLAQQLTHVELERLRHIGPEEFVQAFVNKDPLASTKPCFSDKTSNLEAYVKWFNRLCY 302
Query: 157 WTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWA 214
EI K RA+++ FI VA++ + N +SL A+IS ++ + + RL KTWA
Sbjct: 303 LVATEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWA 360
>AK093160-1|BAC04079.1| 315|Homo sapiens protein ( Homo sapiens
cDNA FLJ35841 fis, clone TESTI2006665, weakly similar to
CELL DIVISION CONTROL PROTEIN 25. ).
Length = 315
Score = 62.9 bits (146), Expect = 3e-09
Identities = 38/118 (32%), Positives = 59/118 (50%), Gaps = 7/118 (5%)
Query: 104 PDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAP-------NVVAFTKRFNRVSF 156
P + QLT ++L + I PEE K + P N+ A+ K FNR+ +
Sbjct: 50 PYTLAQQLTHVELERLRHIGPEEFVQAFVNKDPLASTKPCFSDKTSNLEAYVKWFNRLCY 109
Query: 157 WTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWA 214
EI K RA+++ FI VA++ + N +SL A+IS ++ + + RL KTWA
Sbjct: 110 LVATEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWA 167
>AF449764-1|AAP97676.1| 466|Homo sapiens hypothetical brain protein
protein.
Length = 466
Score = 62.9 bits (146), Expect = 3e-09
Identities = 38/118 (32%), Positives = 59/118 (50%), Gaps = 7/118 (5%)
Query: 104 PDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAP-------NVVAFTKRFNRVSF 156
P + QLT ++L + I PEE K + P N+ A+ K FNR+ +
Sbjct: 201 PYTLAQQLTHVELERLRHIGPEEFVQAFVNKDPLASTKPCFSDKTSNLEAYVKWFNRLCY 260
Query: 157 WTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWA 214
EI K RA+++ FI VA++ + N +SL A+IS ++ + + RL KTWA
Sbjct: 261 LVATEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWA 318
>BC121004-1|AAI21005.1| 431|Homo sapiens RASGEF1B protein protein.
Length = 431
Score = 60.1 bits (139), Expect = 2e-08
Identities = 34/103 (33%), Positives = 55/103 (53%), Gaps = 3/103 (2%)
Query: 143 NVVAFTKRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALH 202
N+ A+ + FNR+S+ EI K RA ++ +FI VA++ + N +SL A+IS ++
Sbjct: 212 NLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMN 271
Query: 203 SASIYRLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLK 245
+ + RL KTWA K +FD L + N+ R L+
Sbjct: 272 MSPVSRLKKTWA---KVKTAKFDILEHQMDPSSNFYNYRTALR 311
>BC121003-1|AAI21004.1| 472|Homo sapiens RasGEF domain family,
member 1B protein.
Length = 472
Score = 60.1 bits (139), Expect = 2e-08
Identities = 34/103 (33%), Positives = 55/103 (53%), Gaps = 3/103 (2%)
Query: 143 NVVAFTKRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALH 202
N+ A+ + FNR+S+ EI K RA ++ +FI VA++ + N +SL A+IS ++
Sbjct: 253 NLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMN 312
Query: 203 SASIYRLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLK 245
+ + RL KTWA K +FD L + N+ R L+
Sbjct: 313 MSPVSRLKKTWA---KVKTAKFDILEHQMDPSSNFYNYRTALR 352
>AK056257-1|BAB71130.1| 473|Homo sapiens protein ( Homo sapiens
cDNA FLJ31695 fis, clone NT2RI2005811, weakly similar to
CELL DIVISION CONTROL PROTEIN 25. ).
Length = 473
Score = 60.1 bits (139), Expect = 2e-08
Identities = 34/103 (33%), Positives = 55/103 (53%), Gaps = 3/103 (2%)
Query: 143 NVVAFTKRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALH 202
N+ A+ + FNR+S+ EI K RA ++ +FI VA++ + N +SL A+IS ++
Sbjct: 254 NLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMN 313
Query: 203 SASIYRLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLK 245
+ + RL KTWA K +FD L + N+ R L+
Sbjct: 314 MSPVSRLKKTWA---KVKTAKFDILEHQMDPSSNFYNYRTALR 353
>AC093747-1|AAY40982.1| 336|Homo sapiens unknown protein.
Length = 336
Score = 58.0 bits (134), Expect = 8e-08
Identities = 27/72 (37%), Positives = 44/72 (61%)
Query: 143 NVVAFTKRFNRVSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALH 202
N+ A+ + FNR+S+ EI K RA ++ +FI VA++ + N +SL A+IS ++
Sbjct: 254 NLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMN 313
Query: 203 SASIYRLTKTWA 214
+ + RL KTWA
Sbjct: 314 MSPVSRLKKTWA 325
>BC022548-1|AAH22548.2| 481|Homo sapiens RasGEF domain family,
member 1A protein.
Length = 481
Score = 51.2 bits (117), Expect = 1e-05
Identities = 40/147 (27%), Positives = 67/147 (45%), Gaps = 11/147 (7%)
Query: 107 VGNQLTLLDLPCFKAIKPEELT--TCGWTKLNK------LTVAPNVVAFTKRFNRVSFWT 158
+ QLT ++L +I PE+L L+ LT ++ A+ FN +S
Sbjct: 218 LAQQLTHIELDRVSSIYPEDLMQIVSHMDSLDNHRCRGDLTKTYSLEAYDNWFNCLSMLV 277
Query: 159 VQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSK 218
E+ K R ++ FI VA++ + N +S+ A+IS ++ + + RL KTW SK
Sbjct: 278 ATEVCRVVKKKHRTRMLEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLKKTW---SK 334
Query: 219 KDKQQFDKLAELFGETDNWTALREYLK 245
+FD L + N+ R L+
Sbjct: 335 VKTAKFDVLEHHMDPSSNFCNYRTALQ 361
>AK095136-1|BAC04491.1| 489|Homo sapiens protein ( Homo sapiens
cDNA FLJ37817 fis, clone BRSSN2003820. ).
Length = 489
Score = 51.2 bits (117), Expect = 1e-05
Identities = 40/147 (27%), Positives = 67/147 (45%), Gaps = 11/147 (7%)
Query: 107 VGNQLTLLDLPCFKAIKPEELT--TCGWTKLNK------LTVAPNVVAFTKRFNRVSFWT 158
+ QLT ++L +I PE+L L+ LT ++ A+ FN +S
Sbjct: 226 LAQQLTHIELDRVSSIYPEDLMQIVSHMDSLDNHRCRGDLTKTYSLEAYDNWFNCLSMLV 285
Query: 159 VQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSK 218
E+ K R ++ FI VA++ + N +S+ A+IS ++ + + RL KTW SK
Sbjct: 286 ATEVCRVVKKKHRTRMLEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLKKTW---SK 342
Query: 219 KDKQQFDKLAELFGETDNWTALREYLK 245
+FD L + N+ R L+
Sbjct: 343 VKTAKFDVLEHHMDPSSNFCNYRTALQ 369
>AL445199-3|CAM24665.1| 1749|Homo sapiens kinase non-catalytic C-lobe
domain (KIND) containing 1 protein.
Length = 1749
Score = 50.8 bits (116), Expect = 1e-05
Identities = 36/161 (22%), Positives = 75/161 (46%), Gaps = 9/161 (5%)
Query: 154 VSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTW 213
VS W EI+ + K + +++ F+ +AK +E N + ++S L ++ R + W
Sbjct: 1544 VSTWVAAEIVTSHTSKLQVNLLSKFLLIAKSCYEQRNFATAMQILSGLEHLAV-RQSPAW 1602
Query: 214 ACLSKKDKQQFDKL--AELFGETDNWTAL--REYLKSISLPCIPYLGIFLTDLVYIDIAH 269
L K + ++L E+F ++D+ + R + +LP L + + L
Sbjct: 1603 RILPAKIAEVMEELKAVEVFLKSDSLCLMEGRRFRAQPTLPSAHLLAMHIQQLETGGFTM 1662
Query: 270 PAGSPHRVTKMNIVLKALER---YQSSEYEIAPLPHVANFL 307
G+ HR +K+ + K + + +Q + Y +P P + ++L
Sbjct: 1663 TNGA-HRWSKLRNIAKVVSQVHAFQENPYTFSPDPKLQSYL 1702
>AL389885-3|CAH73289.1| 1994|Homo sapiens phospholipase C, epsilon 1
protein.
Length = 1994
Score = 50.8 bits (116), Expect = 1e-05
Identities = 38/161 (23%), Positives = 75/161 (46%), Gaps = 13/161 (8%)
Query: 106 DVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNG 165
D+G LPC KA + T T+ + ++V RFN VS W IL
Sbjct: 254 DLGTPECQSSLPCLKASISASILT---TQNGEHNALEDLVM---RFNEVSSWVTWLILTA 307
Query: 166 QSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFD 225
S + + E+ ++ + VAK + N +++ ++ L S ++ K W + + D +
Sbjct: 308 GSMEEKREVFSYLVHVAKCCWNMGNYNAVMEFLAGLRSR---KVLKMWQFMDQSDIETMR 364
Query: 226 KLAELFGETDNWTALREYL-KSISLP-C--IPYLGIFLTDL 262
L + + ++ R+ + +++ +P C +P+ G+FL +L
Sbjct: 365 SLKDAMAQHESSCEYRKVVTRALHIPGCKVVPFCGVFLKEL 405
>AL389885-2|CAH73288.1| 2312|Homo sapiens phospholipase C, epsilon 1
protein.
Length = 2312
Score = 50.8 bits (116), Expect = 1e-05
Identities = 38/161 (23%), Positives = 75/161 (46%), Gaps = 13/161 (8%)
Query: 106 DVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNG 165
D+G LPC KA + T T+ + ++V RFN VS W IL
Sbjct: 562 DLGTPECQSSLPCLKASISASILT---TQNGEHNALEDLVM---RFNEVSSWVTWLILTA 615
Query: 166 QSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFD 225
S + + E+ ++ + VAK + N +++ ++ L S ++ K W + + D +
Sbjct: 616 GSMEEKREVFSYLVHVAKCCWNMGNYNAVMEFLAGLRSR---KVLKMWQFMDQSDIETMR 672
Query: 226 KLAELFGETDNWTALREYL-KSISLP-C--IPYLGIFLTDL 262
L + + ++ R+ + +++ +P C +P+ G+FL +L
Sbjct: 673 SLKDAMAQHESSCEYRKVVTRALHIPGCKVVPFCGVFLKEL 713
>AL365510-3|CAH73758.1| 1994|Homo sapiens phospholipase C, epsilon 1
protein.
Length = 1994
Score = 50.8 bits (116), Expect = 1e-05
Identities = 38/161 (23%), Positives = 75/161 (46%), Gaps = 13/161 (8%)
Query: 106 DVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNG 165
D+G LPC KA + T T+ + ++V RFN VS W IL
Sbjct: 254 DLGTPECQSSLPCLKASISASILT---TQNGEHNALEDLVM---RFNEVSSWVTWLILTA 307
Query: 166 QSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFD 225
S + + E+ ++ + VAK + N +++ ++ L S ++ K W + + D +
Sbjct: 308 GSMEEKREVFSYLVHVAKCCWNMGNYNAVMEFLAGLRSR---KVLKMWQFMDQSDIETMR 364
Query: 226 KLAELFGETDNWTALREYL-KSISLP-C--IPYLGIFLTDL 262
L + + ++ R+ + +++ +P C +P+ G+FL +L
Sbjct: 365 SLKDAMAQHESSCEYRKVVTRALHIPGCKVVPFCGVFLKEL 405
>AL365510-2|CAH73757.1| 2312|Homo sapiens phospholipase C, epsilon 1
protein.
Length = 2312
Score = 50.8 bits (116), Expect = 1e-05
Identities = 38/161 (23%), Positives = 75/161 (46%), Gaps = 13/161 (8%)
Query: 106 DVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNG 165
D+G LPC KA + T T+ + ++V RFN VS W IL
Sbjct: 562 DLGTPECQSSLPCLKASISASILT---TQNGEHNALEDLVM---RFNEVSSWVTWLILTA 615
Query: 166 QSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFD 225
S + + E+ ++ + VAK + N +++ ++ L S ++ K W + + D +
Sbjct: 616 GSMEEKREVFSYLVHVAKCCWNMGNYNAVMEFLAGLRSR---KVLKMWQFMDQSDIETMR 672
Query: 226 KLAELFGETDNWTALREYL-KSISLP-C--IPYLGIFLTDL 262
L + + ++ R+ + +++ +P C +P+ G+FL +L
Sbjct: 673 SLKDAMAQHESSCEYRKVVTRALHIPGCKVVPFCGVFLKEL 713
>AL139124-2|CAI16675.1| 1994|Homo sapiens phospholipase C, epsilon 1
protein.
Length = 1994
Score = 50.8 bits (116), Expect = 1e-05
Identities = 38/161 (23%), Positives = 75/161 (46%), Gaps = 13/161 (8%)
Query: 106 DVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNG 165
D+G LPC KA + T T+ + ++V RFN VS W IL
Sbjct: 254 DLGTPECQSSLPCLKASISASILT---TQNGEHNALEDLVM---RFNEVSSWVTWLILTA 307
Query: 166 QSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFD 225
S + + E+ ++ + VAK + N +++ ++ L S ++ K W + + D +
Sbjct: 308 GSMEEKREVFSYLVHVAKCCWNMGNYNAVMEFLAGLRSR---KVLKMWQFMDQSDIETMR 364
Query: 226 KLAELFGETDNWTALREYL-KSISLP-C--IPYLGIFLTDL 262
L + + ++ R+ + +++ +P C +P+ G+FL +L
Sbjct: 365 SLKDAMAQHESSCEYRKVVTRALHIPGCKVVPFCGVFLKEL 405
>AL139124-1|CAI16674.1| 2312|Homo sapiens phospholipase C, epsilon 1
protein.
Length = 2312
Score = 50.8 bits (116), Expect = 1e-05
Identities = 38/161 (23%), Positives = 75/161 (46%), Gaps = 13/161 (8%)
Query: 106 DVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNG 165
D+G LPC KA + T T+ + ++V RFN VS W IL
Sbjct: 562 DLGTPECQSSLPCLKASISASILT---TQNGEHNALEDLVM---RFNEVSSWVTWLILTA 615
Query: 166 QSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFD 225
S + + E+ ++ + VAK + N +++ ++ L S ++ K W + + D +
Sbjct: 616 GSMEEKREVFSYLVHVAKCCWNMGNYNAVMEFLAGLRSR---KVLKMWQFMDQSDIETMR 672
Query: 226 KLAELFGETDNWTALREYL-KSISLP-C--IPYLGIFLTDL 262
L + + ++ R+ + +++ +P C +P+ G+FL +L
Sbjct: 673 SLKDAMAQHESSCEYRKVVTRALHIPGCKVVPFCGVFLKEL 713
>AL139118-2|CAH70740.1| 1994|Homo sapiens phospholipase C, epsilon 1
protein.
Length = 1994
Score = 50.8 bits (116), Expect = 1e-05
Identities = 38/161 (23%), Positives = 75/161 (46%), Gaps = 13/161 (8%)
Query: 106 DVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNG 165
D+G LPC KA + T T+ + ++V RFN VS W IL
Sbjct: 254 DLGTPECQSSLPCLKASISASILT---TQNGEHNALEDLVM---RFNEVSSWVTWLILTA 307
Query: 166 QSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFD 225
S + + E+ ++ + VAK + N +++ ++ L S ++ K W + + D +
Sbjct: 308 GSMEEKREVFSYLVHVAKCCWNMGNYNAVMEFLAGLRSR---KVLKMWQFMDQSDIETMR 364
Query: 226 KLAELFGETDNWTALREYL-KSISLP-C--IPYLGIFLTDL 262
L + + ++ R+ + +++ +P C +P+ G+FL +L
Sbjct: 365 SLKDAMAQHESSCEYRKVVTRALHIPGCKVVPFCGVFLKEL 405
>AL139118-1|CAH70739.1| 2312|Homo sapiens phospholipase C, epsilon 1
protein.
Length = 2312
Score = 50.8 bits (116), Expect = 1e-05
Identities = 38/161 (23%), Positives = 75/161 (46%), Gaps = 13/161 (8%)
Query: 106 DVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNG 165
D+G LPC KA + T T+ + ++V RFN VS W IL
Sbjct: 562 DLGTPECQSSLPCLKASISASILT---TQNGEHNALEDLVM---RFNEVSSWVTWLILTA 615
Query: 166 QSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFD 225
S + + E+ ++ + VAK + N +++ ++ L S ++ K W + + D +
Sbjct: 616 GSMEEKREVFSYLVHVAKCCWNMGNYNAVMEFLAGLRSR---KVLKMWQFMDQSDIETMR 672
Query: 226 KLAELFGETDNWTALREYL-KSISLP-C--IPYLGIFLTDL 262
L + + ++ R+ + +++ +P C +P+ G+FL +L
Sbjct: 673 SLKDAMAQHESSCEYRKVVTRALHIPGCKVVPFCGVFLKEL 713
>AK131205-1|BAD18397.1| 491|Homo sapiens protein ( Homo sapiens
cDNA FLJ16067 fis, clone FEBRA2001990, weakly similar
to SON OF SEVENLESS PROTEIN HOMOLOG 2. ).
Length = 491
Score = 50.8 bits (116), Expect = 1e-05
Identities = 36/161 (22%), Positives = 75/161 (46%), Gaps = 9/161 (5%)
Query: 154 VSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTW 213
VS W EI+ + K + +++ F+ +AK +E N + ++S L ++ R + W
Sbjct: 286 VSTWVAAEIVTSHTSKLQVNLLSKFLLIAKSCYEQRNFATAMQILSGLEHLAV-RQSPAW 344
Query: 214 ACLSKKDKQQFDKL--AELFGETDNWTAL--REYLKSISLPCIPYLGIFLTDLVYIDIAH 269
L K + ++L E+F ++D+ + R + +LP L + + L
Sbjct: 345 RILPAKIAEVMEELKAVEVFLKSDSLCLMEGRRFRAQPTLPSAHLLAMHIQQLETGGFTM 404
Query: 270 PAGSPHRVTKMNIVLKALER---YQSSEYEIAPLPHVANFL 307
G+ HR +K+ + K + + +Q + Y +P P + ++L
Sbjct: 405 TNGA-HRWSKLRNIAKVVSQVHAFQENPYTFSPDPKLQSYL 444
>AF190642-1|AAG17145.2| 2303|Homo sapiens phosphoinositide-specific
phospholipase C PLC-epsilon protein.
Length = 2303
Score = 50.8 bits (116), Expect = 1e-05
Identities = 38/161 (23%), Positives = 75/161 (46%), Gaps = 13/161 (8%)
Query: 106 DVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNG 165
D+G LPC KA + T T+ + ++V RFN VS W IL
Sbjct: 562 DLGTPECQSSLPCLKASISASILT---TQNGEHNALEDLVM---RFNEVSSWVTWLILTA 615
Query: 166 QSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFD 225
S + + E+ ++ + VAK + N +++ ++ L S ++ K W + + D +
Sbjct: 616 GSMEEKREVFSYLVHVAKCCWNMGNYNAVMEFLAGLRSR---KVLKMWQFMDQSDIETMR 672
Query: 226 KLAELFGETDNWTALREYL-KSISLP-C--IPYLGIFLTDL 262
L + + ++ R+ + +++ +P C +P+ G+FL +L
Sbjct: 673 SLKDAMAQHESSCEYRKVVTRALHIPGCKVVPFCGVFLKEL 713
>AB040949-1|BAA96040.2| 2304|Homo sapiens KIAA1516 protein protein.
Length = 2304
Score = 50.8 bits (116), Expect = 1e-05
Identities = 38/161 (23%), Positives = 75/161 (46%), Gaps = 13/161 (8%)
Query: 106 DVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNG 165
D+G LPC KA + T T+ + ++V RFN VS W IL
Sbjct: 564 DLGTPECQSSLPCLKASISASILT---TQNGEHNALEDLVM---RFNEVSSWVTWLILTA 617
Query: 166 QSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFD 225
S + + E+ ++ + VAK + N +++ ++ L S ++ K W + + D +
Sbjct: 618 GSMEEKREVFSYLVHVAKCCWNMGNYNAVMEFLAGLRSR---KVLKMWQFMDQSDIETMR 674
Query: 226 KLAELFGETDNWTALREYL-KSISLP-C--IPYLGIFLTDL 262
L + + ++ R+ + +++ +P C +P+ G+FL +L
Sbjct: 675 SLKDAMAQHESSCEYRKVVTRALHIPGCKVVPFCGVFLKEL 715
>BC047924-1|AAH47924.1| 500|Homo sapiens KNDC1 protein protein.
Length = 500
Score = 50.4 bits (115), Expect = 2e-05
Identities = 36/161 (22%), Positives = 75/161 (46%), Gaps = 9/161 (5%)
Query: 154 VSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTW 213
VS W EI+ + K + +++ F+ +AK +E N + ++S L ++ R + W
Sbjct: 295 VSTWVAAEIVTSHTSKLQVNLLSKFLLIAKSCYEQRNFATAMQILSGLEHLAV-RQSPAW 353
Query: 214 ACLSKKDKQQFDKL--AELFGETDNWTAL--REYLKSISLPCIPYLGIFLTDLVYIDIAH 269
L K + ++L E+F ++D+ + R + +LP L + + L
Sbjct: 354 RFLPAKIAEVMEELKAVEVFLKSDSLCLMEGRRFRAQPTLPSAHLLAMHIQQLETGGFTM 413
Query: 270 PAGSPHRVTKMNIVLKALER---YQSSEYEIAPLPHVANFL 307
G+ HR +K+ + K + + +Q + Y +P P + ++L
Sbjct: 414 TNGA-HRWSKLRNIAKVVSQVHAFQENPYTFSPDPKLQSYL 453
>AB000781-1|BAD12625.1| 1684|Homo sapiens cerebral protein-9 protein.
Length = 1684
Score = 50.4 bits (115), Expect = 2e-05
Identities = 36/161 (22%), Positives = 74/161 (45%), Gaps = 9/161 (5%)
Query: 154 VSFWTVQEILNGQSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTW 213
VS W EI+ + K + +++ F+ +AK +E N + ++S L ++ R + W
Sbjct: 1479 VSTWVAAEIVTSHTSKLQVNLLSKFLLIAKSCYEQRNFATAMQILSGLEHLAV-RQSPAW 1537
Query: 214 ACLSKKDKQQFDKL--AELFGETDNWTAL--REYLKSISLPCIPYLGIFLTDLVYIDIAH 269
L K + ++L E+F +D+ + R + +LP L + + L
Sbjct: 1538 RILPAKIAEVMEELKAVEVFLRSDSLCLMEGRRFRAQPTLPSAHLLAMHIQQLETGGFTM 1597
Query: 270 PAGSPHRVTKMNIVLKALER---YQSSEYEIAPLPHVANFL 307
G+ HR +K+ + K + + +Q + Y +P P + ++L
Sbjct: 1598 TNGA-HRWSKLRNIAKVVSQVHAFQENPYTFSPDPKLQSYL 1637
>AF170071-1|AAG28341.1| 1994|Homo sapiens phospholipase C epsilon
protein.
Length = 1994
Score = 49.6 bits (113), Expect = 3e-05
Identities = 38/161 (23%), Positives = 74/161 (45%), Gaps = 13/161 (8%)
Query: 106 DVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSFWTVQEILNG 165
D+G LPC KA + T T+ + ++V RFN VS W IL
Sbjct: 254 DLGTPECQSSLPCLKASISASILT---TQNGEHNALEDLVM---RFNEVSSWVTWLILTA 307
Query: 166 QSPKARAEIMAHFIKVAKKLHELNNLHSLFAVISALHSASIYRLTKTWACLSKKDKQQFD 225
S + + E+ ++ + VAK + N +++ ++ L S ++ K W + + D +
Sbjct: 308 GSMEEKREVFSYLVHVAKCCWNMGNYNAVMEFLAGLRSR---KVLKMWQFMDQSDIETMR 364
Query: 226 KLAELFGETDNWTALREYL-KSISLP-C--IPYLGIFLTDL 262
L + + ++ R+ + +++ +P C P+ G+FL +L
Sbjct: 365 SLKDAMAQHESSCEYRKVVTRALHIPGCKVFPFCGVFLKEL 405
>AF295775-1|AAG10221.1| 211|Homo sapiens ral guanine nucleotide
dissociation stimulator protein.
Length = 211
Score = 46.0 bits (104), Expect = 4e-04
Identities = 29/85 (34%), Positives = 43/85 (50%), Gaps = 5/85 (5%)
Query: 104 PDDVGNQLTLLDLPCFKAIKPEELTTCGWT---KLNKLTVAPNVVAFTKRFNRVSFWTVQ 160
PD V Q TL+D FK + P W+ K K +AP + A +FN V+ +
Sbjct: 127 PDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQFNSVANCVIT 186
Query: 161 EILNGQSPKA--RAEIMAHFIKVAK 183
L +S KA RA ++ H+I+VA+
Sbjct: 187 TCLGNRSTKAPDRARVVEHWIEVAR 211
>BC019329-1|AAH19329.1| 198|Homo sapiens RALGPS1 protein protein.
Length = 198
Score = 44.8 bits (101), Expect = 8e-04
Identities = 16/38 (42%), Positives = 31/38 (81%)
Query: 89 NQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEE 126
++S+D +V L+++P++ +Q+TL+D+P FKAI+PE+
Sbjct: 126 SKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPEK 163
>AL160169-7|CAI40644.1| 108|Homo sapiens Ral GEF with PH domain and
SH3 binding motif 1 protein.
Length = 108
Score = 44.8 bits (101), Expect = 8e-04
Identities = 16/38 (42%), Positives = 31/38 (81%)
Query: 89 NQSWDDIVCSALRLSPDDVGNQLTLLDLPCFKAIKPEE 126
++S+D +V L+++P++ +Q+TL+D+P FKAI+PE+
Sbjct: 36 SKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPEK 73
>AK097292-1|BAC04992.1| 202|Homo sapiens protein ( Homo sapiens
cDNA FLJ39973 fis, clone SPLEN2028365, moderately
similar to Mus musculus ras activator RasGRP (Rasgrp)
mRNA. ).
Length = 202
Score = 41.1 bits (92), Expect = 0.010
Identities = 38/144 (26%), Positives = 63/144 (43%), Gaps = 4/144 (2%)
Query: 196 AVISALHSASIYRLTKTWACLSKKDKQQFDKLAELFGETDNWTALREYLKSISLPCIPYL 255
AV L ++I RL + A LS + +L EL +N+ R + +P L
Sbjct: 2 AVTGGLCHSAISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVL 61
Query: 256 GIFLTDLVYIDIAHPAGSPH---RVTKMNIVLKALERYQSSEYEIAPLPHVANFLNSVRY 312
G+ L DLV + A P P + K+N + L+ + + + P + L+ +
Sbjct: 62 GVHLKDLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTL 121
Query: 313 IEELQKFVEDDQYKLSLKLEPPSP 336
+L + ED+ Y+LS EP P
Sbjct: 122 SLDL-FYTEDEIYELSYAREPRCP 144
>BC033198-1|AAH33198.1| 411|Homo sapiens Unknown (protein for
IMAGE:4852125) protein.
Length = 411
Score = 37.1 bits (82), Expect = 0.17
Identities = 32/96 (33%), Positives = 45/96 (46%), Gaps = 14/96 (14%)
Query: 252 IPYLGIFLTDLVYIDIAHPAGSPHRV------TKMNIVLKALERYQS--SEYEIAPLPHV 303
+PYLG FLTDLV +D A R+ K V+ ++ QS + Y IAP
Sbjct: 61 VPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNYSIAPDEQF 120
Query: 304 ANFLNSVRYIEELQKFVEDDQYKLSLKLEPPSPVGS 339
+ +V ++ E + Y LS +LEPPS S
Sbjct: 121 GAWFRAV------ERLSETESYNLSCELEPPSESAS 150
>AL160276-5|CAI40649.1| 318|Homo sapiens Rap guanine nucleotide
exchange factor (GEF) 1 protein.
Length = 318
Score = 35.5 bits (78), Expect = 0.52
Identities = 18/51 (35%), Positives = 27/51 (52%), Gaps = 2/51 (3%)
Query: 106 DVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVAPNVVAFTKRFNRVSF 156
++ QLTLLD F I+ E+ W K +PN+ FT+ FN +S+
Sbjct: 270 EIAEQLTLLDAELFYKIEIPEVLL--WAKEQNEEKSPNLTQFTEHFNNMSY 318
>AK125459-1|BAC86170.1| 1268|Homo sapiens protein ( Homo sapiens
cDNA FLJ43470 fis, clone OCBBF2037547, highly similar
to Homo sapiens T-cell lymphoma invasion and metastasis
2 (TIAM2). ).
Length = 1268
Score = 35.1 bits (77), Expect = 0.68
Identities = 22/99 (22%), Positives = 46/99 (46%), Gaps = 6/99 (6%)
Query: 462 TILKEGRKISLSS---WQRYWLQMSGNMLFFYGAKSFKGTNRSDFRSERCKVLTLVGWIA 518
T+ KE RK+ L + W++YW+ + G L FY +++ + + RC + +
Sbjct: 58 TVQKE-RKLELVARRKWKQYWVTLKGCTLLFY--ETYGKNSMDQSSAPRCALFAEDSIVQ 114
Query: 519 VWADGDAADAFQLINHHSGTVYKFKAGSEYAAKQWIAKI 557
+ + +++ G VY F+A S+ + W+ +
Sbjct: 115 SVPEHPKKENVFCLSNSFGDVYLFQATSQTDLENWVTAV 153
>AF225988-1|AAF35390.1| 1980|Homo sapiens voltage-gated sodium channel
alpha subunit protein.
Length = 1980
Score = 35.1 bits (77), Expect = 0.68
Identities = 22/73 (30%), Positives = 36/73 (49%), Gaps = 7/73 (9%)
Query: 392 SLGSNIFGKSHTEDKMDEKTPAGSVNLLDDTLLESPSSVACAKMSQSLPHSNITKPEDI- 450
++G + F +TED E P GS + LDDT S++ + +P + +PE+
Sbjct: 1099 AVGESDFENLNTEDVSSESDPEGSKDKLDDTSSSEGSTIDIKPEVEEVP---VEQPEEYL 1155
Query: 451 ---QCDFQGCVKR 460
C +GCV+R
Sbjct: 1156 DPDACFTEGCVQR 1168
>AF050736-1|AAD15789.1| 1980|Homo sapiens voltage-gated sodium channel
alpha subunit protein.
Length = 1980
Score = 35.1 bits (77), Expect = 0.68
Identities = 22/73 (30%), Positives = 36/73 (49%), Gaps = 7/73 (9%)
Query: 392 SLGSNIFGKSHTEDKMDEKTPAGSVNLLDDTLLESPSSVACAKMSQSLPHSNITKPEDI- 450
++G + F +TED E P GS + LDDT S++ + +P + +PE+
Sbjct: 1099 AVGESDFENLNTEDVSSESDPEGSKDKLDDTSSSEGSTIDIKPEVEEVP---VEQPEEYL 1155
Query: 451 ---QCDFQGCVKR 460
C +GCV+R
Sbjct: 1156 DPDACFTEGCVQR 1168
>AB209674-1|BAD92911.1| 1947|Homo sapiens T-cell lymphoma invasion
and metastasis 2 variant protein.
Length = 1947
Score = 35.1 bits (77), Expect = 0.68
Identities = 22/99 (22%), Positives = 46/99 (46%), Gaps = 6/99 (6%)
Query: 462 TILKEGRKISLSS---WQRYWLQMSGNMLFFYGAKSFKGTNRSDFRSERCKVLTLVGWIA 518
T+ KE RK+ L + W++YW+ + G L FY +++ + + RC + +
Sbjct: 766 TVQKE-RKLELVARRKWKQYWVTLKGCTLLFY--ETYGKNSMDQSSAPRCALFAEDSIVQ 822
Query: 519 VWADGDAADAFQLINHHSGTVYKFKAGSEYAAKQWIAKI 557
+ + +++ G VY F+A S+ + W+ +
Sbjct: 823 SVPEHPKKENVFCLSNSFGDVYLFQATSQTDLENWVTAV 861
>AB095936-1|BAC23112.2| 1715|Homo sapiens KIAA2016 protein protein.
Length = 1715
Score = 35.1 bits (77), Expect = 0.68
Identities = 22/99 (22%), Positives = 46/99 (46%), Gaps = 6/99 (6%)
Query: 462 TILKEGRKISLSS---WQRYWLQMSGNMLFFYGAKSFKGTNRSDFRSERCKVLTLVGWIA 518
T+ KE RK+ L + W++YW+ + G L FY +++ + + RC + +
Sbjct: 534 TVQKE-RKLELVARRKWKQYWVTLKGCTLLFY--ETYGKNSMDQSSAPRCALFAEDSIVQ 590
Query: 519 VWADGDAADAFQLINHHSGTVYKFKAGSEYAAKQWIAKI 557
+ + +++ G VY F+A S+ + W+ +
Sbjct: 591 SVPEHPKKENVFCLSNSFGDVYLFQATSQTDLENWVTAV 629
>AB027567-1|BAA78033.1| 1980|Homo sapiens sodium channel protein.
Length = 1980
Score = 35.1 bits (77), Expect = 0.68
Identities = 22/73 (30%), Positives = 36/73 (49%), Gaps = 7/73 (9%)
Query: 392 SLGSNIFGKSHTEDKMDEKTPAGSVNLLDDTLLESPSSVACAKMSQSLPHSNITKPEDI- 450
++G + F +TED E P GS + LDDT S++ + +P + +PE+
Sbjct: 1099 AVGESDFENLNTEDVSSESDPEGSKDKLDDTSSSEGSTIDIKPEVEEVP---VEQPEEYL 1155
Query: 451 ---QCDFQGCVKR 460
C +GCV+R
Sbjct: 1156 DPDACFTEGCVQR 1168
>U16296-1|AAA98443.1| 1591|Homo sapiens TIAM1 protein protein.
Length = 1591
Score = 34.3 bits (75), Expect = 1.2
Identities = 21/103 (20%), Positives = 43/103 (41%), Gaps = 5/103 (4%)
Query: 458 VKRKTILKEGRKISLSS---WQRYWLQMSGNMLFFYGAKSFKGTNRSDFRSERCKVLTLV 514
VK + K+ +K+ ++ W+ YW+ + G LFFY + G + + V +
Sbjct: 442 VKNFLVHKKNKKVESATRRKWKHYWVSLKGCTLFFYESDGRSGIDHNSIPKHAVWVENSI 501
Query: 515 GWIAVWADGDAADAFQLINHHSGTVYKFKAGSEYAAKQWIAKI 557
+ + D +++ G + F+ S+ + WI I
Sbjct: 502 --VQAVPEHPKKDFVFCLSNSLGDAFLFQTTSQTELENWITAI 542
>BC117196-1|AAI17197.1| 1591|Homo sapiens T-cell lymphoma invasion
and metastasis 1 protein.
Length = 1591
Score = 34.3 bits (75), Expect = 1.2
Identities = 21/103 (20%), Positives = 43/103 (41%), Gaps = 5/103 (4%)
Query: 458 VKRKTILKEGRKISLSS---WQRYWLQMSGNMLFFYGAKSFKGTNRSDFRSERCKVLTLV 514
VK + K+ +K+ ++ W+ YW+ + G LFFY + G + + V +
Sbjct: 442 VKNFLVHKKNKKVESATRRKWKHYWVSLKGCTLFFYESDGRSGIDHNSIPKHAVWVENSI 501
Query: 515 GWIAVWADGDAADAFQLINHHSGTVYKFKAGSEYAAKQWIAKI 557
+ + D +++ G + F+ S+ + WI I
Sbjct: 502 --VQAVPEHPKKDFVFCLSNSLGDAFLFQTTSQTELENWITAI 542
>BC117192-1|AAI17193.1| 1591|Homo sapiens T-cell lymphoma invasion
and metastasis 1 protein.
Length = 1591
Score = 34.3 bits (75), Expect = 1.2
Identities = 21/103 (20%), Positives = 43/103 (41%), Gaps = 5/103 (4%)
Query: 458 VKRKTILKEGRKISLSS---WQRYWLQMSGNMLFFYGAKSFKGTNRSDFRSERCKVLTLV 514
VK + K+ +K+ ++ W+ YW+ + G LFFY + G + + V +
Sbjct: 442 VKNFLVHKKNKKVESATRRKWKHYWVSLKGCTLFFYESDGRSGIDHNSIPKHAVWVENSI 501
Query: 515 GWIAVWADGDAADAFQLINHHSGTVYKFKAGSEYAAKQWIAKI 557
+ + D +++ G + F+ S+ + WI I
Sbjct: 502 --VQAVPEHPKKDFVFCLSNSLGDAFLFQTTSQTELENWITAI 542
>AB209101-1|BAD92338.1| 1060|Homo sapiens T-cell lymphoma invasion
and metastasis 1 variant protein.
Length = 1060
Score = 34.3 bits (75), Expect = 1.2
Identities = 21/103 (20%), Positives = 43/103 (41%), Gaps = 5/103 (4%)
Query: 458 VKRKTILKEGRKISLSS---WQRYWLQMSGNMLFFYGAKSFKGTNRSDFRSERCKVLTLV 514
VK + K+ +K+ ++ W+ YW+ + G LFFY + G + + V +
Sbjct: 271 VKNFLVHKKNKKVESATRRKWKHYWVSLKGCTLFFYESDGRSGIDHNSIPKHAVWVENSI 330
Query: 515 GWIAVWADGDAADAFQLINHHSGTVYKFKAGSEYAAKQWIAKI 557
+ + D +++ G + F+ S+ + WI I
Sbjct: 331 --VQAVPEHPKKDFVFCLSNSLGDAFLFQTTSQTELENWITAI 371
>BC071592-1|AAH71592.1| 1076|Homo sapiens FARP1 protein protein.
Length = 1076
Score = 33.9 bits (74), Expect = 1.6
Identities = 23/97 (23%), Positives = 43/97 (44%), Gaps = 11/97 (11%)
Query: 473 SSWQRYWLQMSGNMLFFYGAKSFKGTNRSDFRSERCKVLTLVGW-IAVWADGDAADAFQL 531
+ WQ+ W+ + LFFY +S + L L+G+ + + ++ + +
Sbjct: 978 NGWQKLWVVFTNFCLFFY---------KSHQDNHPLASLPLLGYSLTIPSESENIQKDYV 1028
Query: 532 IN-HHSGTVYKFKAGSEYAAKQWIAKIEEVTNKIVKP 567
H VY F+A SEY ++W+ I T+ +P
Sbjct: 1029 FKLHFKSHVYYFRAESEYTFERWMEVIRSATSSASRP 1065
>BC041595-1|AAH41595.1| 1045|Homo sapiens FERM, RhoGEF (ARHGEF) and
pleckstrin domain protein 1 (chondrocyte-derived)
protein.
Length = 1045
Score = 33.9 bits (74), Expect = 1.6
Identities = 23/97 (23%), Positives = 43/97 (44%), Gaps = 11/97 (11%)
Query: 473 SSWQRYWLQMSGNMLFFYGAKSFKGTNRSDFRSERCKVLTLVGW-IAVWADGDAADAFQL 531
+ WQ+ W+ + LFFY +S + L L+G+ + + ++ + +
Sbjct: 947 NGWQKLWVVFTNFCLFFY---------KSHQDNHPLASLPLLGYSLTIPSESENIQKDYV 997
Query: 532 IN-HHSGTVYKFKAGSEYAAKQWIAKIEEVTNKIVKP 567
H VY F+A SEY ++W+ I T+ +P
Sbjct: 998 FKLHFKSHVYYFRAESEYTFERWMEVIRSATSSASRP 1034
>AL161896-1|CAI12946.1| 1045|Homo sapiens FERM, RhoGEF (ARHGEF) and
pleckstrin domain protein 1 (chondrocyte-derived)
protein.
Length = 1045
Score = 33.9 bits (74), Expect = 1.6
Identities = 23/97 (23%), Positives = 43/97 (44%), Gaps = 11/97 (11%)
Query: 473 SSWQRYWLQMSGNMLFFYGAKSFKGTNRSDFRSERCKVLTLVGW-IAVWADGDAADAFQL 531
+ WQ+ W+ + LFFY +S + L L+G+ + + ++ + +
Sbjct: 947 NGWQKLWVVFTNFCLFFY---------KSHQDNHPLASLPLLGYSLTIPSESENIQKDYV 997
Query: 532 IN-HHSGTVYKFKAGSEYAAKQWIAKIEEVTNKIVKP 567
H VY F+A SEY ++W+ I T+ +P
Sbjct: 998 FKLHFKSHVYYFRAESEYTFERWMEVIRSATSSASRP 1034
>AL137249-8|CAI39458.1| 1045|Homo sapiens FERM, RhoGEF (ARHGEF) and
pleckstrin domain protein 1 (chondrocyte-derived)
protein.
Length = 1045
Score = 33.9 bits (74), Expect = 1.6
Identities = 23/97 (23%), Positives = 43/97 (44%), Gaps = 11/97 (11%)
Query: 473 SSWQRYWLQMSGNMLFFYGAKSFKGTNRSDFRSERCKVLTLVGW-IAVWADGDAADAFQL 531
+ WQ+ W+ + LFFY +S + L L+G+ + + ++ + +
Sbjct: 947 NGWQKLWVVFTNFCLFFY---------KSHQDNHPLASLPLLGYSLTIPSESENIQKDYV 997
Query: 532 IN-HHSGTVYKFKAGSEYAAKQWIAKIEEVTNKIVKP 567
H VY F+A SEY ++W+ I T+ +P
Sbjct: 998 FKLHFKSHVYYFRAESEYTFERWMEVIRSATSSASRP 1034
>AL136300-3|CAI10953.1| 1045|Homo sapiens FERM, RhoGEF (ARHGEF) and
pleckstrin domain protein 1 (chondrocyte-derived)
protein.
Length = 1045
Score = 33.9 bits (74), Expect = 1.6
Identities = 23/97 (23%), Positives = 43/97 (44%), Gaps = 11/97 (11%)
Query: 473 SSWQRYWLQMSGNMLFFYGAKSFKGTNRSDFRSERCKVLTLVGW-IAVWADGDAADAFQL 531
+ WQ+ W+ + LFFY +S + L L+G+ + + ++ + +
Sbjct: 947 NGWQKLWVVFTNFCLFFY---------KSHQDNHPLASLPLLGYSLTIPSESENIQKDYV 997
Query: 532 IN-HHSGTVYKFKAGSEYAAKQWIAKIEEVTNKIVKP 567
H VY F+A SEY ++W+ I T+ +P
Sbjct: 998 FKLHFKSHVYYFRAESEYTFERWMEVIRSATSSASRP 1034
>AB008430-1|BAA24267.1| 1045|Homo sapiens CDEP protein.
Length = 1045
Score = 33.9 bits (74), Expect = 1.6
Identities = 23/97 (23%), Positives = 43/97 (44%), Gaps = 11/97 (11%)
Query: 473 SSWQRYWLQMSGNMLFFYGAKSFKGTNRSDFRSERCKVLTLVGW-IAVWADGDAADAFQL 531
+ WQ+ W+ + LFFY +S + L L+G+ + + ++ + +
Sbjct: 947 NGWQKLWVVFTNFCLFFY---------KSHQDNHPLASLPLLGYSLTIPSESENIQKDYV 997
Query: 532 IN-HHSGTVYKFKAGSEYAAKQWIAKIEEVTNKIVKP 567
H VY F+A SEY ++W+ I T+ +P
Sbjct: 998 FKLHFKSHVYYFRAESEYTFERWMEVIRSATSSASRP 1034
>BC125226-1|AAI25227.1| 639|Homo sapiens FGD6 protein protein.
Length = 639
Score = 33.1 bits (72), Expect = 2.7
Identities = 22/87 (25%), Positives = 38/87 (43%), Gaps = 8/87 (9%)
Query: 475 WQRYWLQMSGNMLFFYGAKSFKGTNRSDFRSERCKVLTLVGWIAVWADGDAADAFQLINH 534
W+ +W + +L+ Y A D + + L I V + + FQL+ H
Sbjct: 559 WKHFWFVIKNKVLYTYAASE-------DVAALESQPLLGFTVIQVKDENSESKVFQLL-H 610
Query: 535 HSGTVYKFKAGSEYAAKQWIAKIEEVT 561
+ Y FKA ++A++WI +E T
Sbjct: 611 KNMLFYVFKAEDAHSAQKWIEAFQEGT 637
>BC125225-1|AAI25226.1| 639|Homo sapiens FGD6 protein protein.
Length = 639
Score = 33.1 bits (72), Expect = 2.7
Identities = 22/87 (25%), Positives = 38/87 (43%), Gaps = 8/87 (9%)
Query: 475 WQRYWLQMSGNMLFFYGAKSFKGTNRSDFRSERCKVLTLVGWIAVWADGDAADAFQLINH 534
W+ +W + +L+ Y A D + + L I V + + FQL+ H
Sbjct: 559 WKHFWFVIKNKVLYTYAASE-------DVAALESQPLLGFTVIQVKDENSESKVFQLL-H 610
Query: 535 HSGTVYKFKAGSEYAAKQWIAKIEEVT 561
+ Y FKA ++A++WI +E T
Sbjct: 611 KNMLFYVFKAEDAHSAQKWIEAFQEGT 637
>BC113555-1|AAI13556.1| 833|Homo sapiens ventricular zone expressed
PH domain homolog 1 (zebrafish) protein.
Length = 833
Score = 33.1 bits (72), Expect = 2.7
Identities = 28/113 (24%), Positives = 47/113 (41%), Gaps = 4/113 (3%)
Query: 442 SNITKPEDIQCDFQGCVKRKTILKEGRKISLSSWQRYWLQMSGNMLFFYGAKSFKGTNRS 501
+N K + D Q ++ K K+ R + W+ + ++GN L F KS +
Sbjct: 703 NNPEKATVVNQDGQPLIEGKLKEKQVRWKFIKRWKTRYFTLAGNQLLFQKGKS--KDDPD 760
Query: 502 DFRSERCKVLTLVGWIAVWADGDAADAFQLINHHSGTVYKFKAGSEYAAKQWI 554
D E KV ++ D AF++ + Y FKA E A++W+
Sbjct: 761 DCPIELSKVQSVKAVAKKRRDRSLPRAFEIFTDNK--TYVFKAKDEKNAEEWL 811
>BC111017-1|AAI11018.1| 788|Homo sapiens VEPH1 protein protein.
Length = 788
Score = 33.1 bits (72), Expect = 2.7
Identities = 28/113 (24%), Positives = 47/113 (41%), Gaps = 4/113 (3%)
Query: 442 SNITKPEDIQCDFQGCVKRKTILKEGRKISLSSWQRYWLQMSGNMLFFYGAKSFKGTNRS 501
+N K + D Q ++ K K+ R + W+ + ++GN L F KS +
Sbjct: 658 NNPEKATVVNQDGQPLIEGKLKEKQVRWKFIKRWKTRYFTLAGNQLLFQKGKS--KDDPD 715
Query: 502 DFRSERCKVLTLVGWIAVWADGDAADAFQLINHHSGTVYKFKAGSEYAAKQWI 554
D E KV ++ D AF++ + Y FKA E A++W+
Sbjct: 716 DCPIELSKVQSVKAVAKKRRDRSLPRAFEIFTDNK--TYVFKAKDEKNAEEWL 766
>BC101660-1|AAI01661.1| 833|Homo sapiens ventricular zone expressed
PH domain homolog 1 protein.
Length = 833
Score = 33.1 bits (72), Expect = 2.7
Identities = 28/113 (24%), Positives = 47/113 (41%), Gaps = 4/113 (3%)
Query: 442 SNITKPEDIQCDFQGCVKRKTILKEGRKISLSSWQRYWLQMSGNMLFFYGAKSFKGTNRS 501
+N K + D Q ++ K K+ R + W+ + ++GN L F KS +
Sbjct: 703 NNPEKATVVNQDGQPLIEGKLKEKQVRWKFIKRWKTRYFTLAGNQLLFQKGKS--KDDPD 760
Query: 502 DFRSERCKVLTLVGWIAVWADGDAADAFQLINHHSGTVYKFKAGSEYAAKQWI 554
D E KV ++ D AF++ + Y FKA E A++W+
Sbjct: 761 DCPIELSKVQSVKAVAKKRRDRSLPRAFEIFTDNK--TYVFKAKDEKNAEEWL 811
>BC042159-1|AAH42159.1| 459|Homo sapiens VEPH1 protein protein.
Length = 459
Score = 33.1 bits (72), Expect = 2.7
Identities = 28/113 (24%), Positives = 47/113 (41%), Gaps = 4/113 (3%)
Query: 442 SNITKPEDIQCDFQGCVKRKTILKEGRKISLSSWQRYWLQMSGNMLFFYGAKSFKGTNRS 501
+N K + D Q ++ K K+ R + W+ + ++GN L F KS +
Sbjct: 329 NNPEKATVVNQDGQPLIEGKLKEKQVRWKFIKRWKTRYFTLAGNQLLFQKGKS--KDDPD 386
Query: 502 DFRSERCKVLTLVGWIAVWADGDAADAFQLINHHSGTVYKFKAGSEYAAKQWI 554
D E KV ++ D AF++ + Y FKA E A++W+
Sbjct: 387 DCPIELSKVQSVKAVAKKRRDRSLPRAFEIFTDNK--TYVFKAKDEKNAEEWL 437
>BC038976-1|AAH38976.2| 475|Homo sapiens Rho GTPase activating
protein 15 protein.
Length = 475
Score = 33.1 bits (72), Expect = 2.7
Identities = 34/162 (20%), Positives = 69/162 (42%), Gaps = 7/162 (4%)
Query: 408 DEKTPAGSVNLLDDTLLESPSSVACAKMSQSLPHSNITKPEDIQCDFQGCVKRKTILKEG 467
D + + S+ L D + P S SQ + I E + + +G +++ I G
Sbjct: 36 DRLSQSKSMILTDVGKVTEPISRHRRNHSQHILKDVIPPLEQLMVEKEGYLQKAKIADGG 95
Query: 468 RKISLSSWQRYWLQMSGNMLFFYGAKSFKGTNRSDFRS-ERCKVLTLVGWIAVWADGDAA 526
+K+ +W W+ +S + FY K K S+ ++ + + + L G WA ++
Sbjct: 96 KKLR-KNWSTSWIVLSSRRIEFY--KESKQQALSNMKTGHKPESVDLCGAHIEWAKEKSS 152
Query: 527 --DAFQLINHHSGTVYKFKAGSEYAAKQWIAKIEEVTNKIVK 566
+ FQ I SG + ++ ++ W I+ +++ K
Sbjct: 153 RKNVFQ-ITTVSGNEFLLQSDIDFIILDWFHAIKNAIDRLPK 193
>BC016701-1|AAH16701.1| 475|Homo sapiens Rho GTPase activating
protein 15 protein.
Length = 475
Score = 33.1 bits (72), Expect = 2.7
Identities = 34/162 (20%), Positives = 69/162 (42%), Gaps = 7/162 (4%)
Query: 408 DEKTPAGSVNLLDDTLLESPSSVACAKMSQSLPHSNITKPEDIQCDFQGCVKRKTILKEG 467
D + + S+ L D + P S SQ + I E + + +G +++ I G
Sbjct: 36 DRLSQSKSMILTDVGKVTEPISRHRRNHSQHILKDVIPPLEQLMVEKEGYLQKAKIADGG 95
Query: 468 RKISLSSWQRYWLQMSGNMLFFYGAKSFKGTNRSDFRS-ERCKVLTLVGWIAVWADGDAA 526
+K+ +W W+ +S + FY K K S+ ++ + + + L G WA ++
Sbjct: 96 KKLR-KNWSTSWIVLSSRRIEFY--KESKQQALSNMKTGHKPESVDLCGAHIEWAKEKSS 152
Query: 527 --DAFQLINHHSGTVYKFKAGSEYAAKQWIAKIEEVTNKIVK 566
+ FQ I SG + ++ ++ W I+ +++ K
Sbjct: 153 RKNVFQ-ITTVSGNEFLLQSDIDFIILDWFHAIKNAIDRLPK 193
>AY219338-1|AAO34684.1| 475|Homo sapiens ARHGAP15 protein.
Length = 475
Score = 33.1 bits (72), Expect = 2.7
Identities = 34/162 (20%), Positives = 69/162 (42%), Gaps = 7/162 (4%)
Query: 408 DEKTPAGSVNLLDDTLLESPSSVACAKMSQSLPHSNITKPEDIQCDFQGCVKRKTILKEG 467
D + + S+ L D + P S SQ + I E + + +G +++ I G
Sbjct: 36 DRLSQSKSMILTDVGKVTEPISRHRRNHSQHILKDVIPPLEQLMVEKEGYLQKAKIADGG 95
Query: 468 RKISLSSWQRYWLQMSGNMLFFYGAKSFKGTNRSDFRS-ERCKVLTLVGWIAVWADGDAA 526
+K+ +W W+ +S + FY K K S+ ++ + + + L G WA ++
Sbjct: 96 KKLR-KNWSTSWIVLSSRRIEFY--KESKQQALSNMKTGHKPESVDLCGAHIEWAKEKSS 152
Query: 527 --DAFQLINHHSGTVYKFKAGSEYAAKQWIAKIEEVTNKIVK 566
+ FQ I SG + ++ ++ W I+ +++ K
Sbjct: 153 RKNVFQ-ITTVSGNEFLLQSDIDFIILDWFHAIKNAIDRLPK 193
>AK128492-1|BAC87464.1| 1053|Homo sapiens protein ( Homo sapiens cDNA
FLJ46642 fis, clone TRACH3003037, weakly similar to
Rho/Rac guanine nucleotide exchange factor. ).
Length = 1053
Score = 33.1 bits (72), Expect = 2.7
Identities = 22/87 (25%), Positives = 38/87 (43%), Gaps = 8/87 (9%)
Query: 475 WQRYWLQMSGNMLFFYGAKSFKGTNRSDFRSERCKVLTLVGWIAVWADGDAADAFQLINH 534
W+ +W + +L+ Y A D + + L I V + + FQL+ H
Sbjct: 973 WKHFWFVIKNKVLYTYAASE-------DVAALESQPLLGFTVIQVKDENSESKVFQLL-H 1024
Query: 535 HSGTVYKFKAGSEYAAKQWIAKIEEVT 561
+ Y FKA ++A++WI +E T
Sbjct: 1025 KNMLFYVFKAEDAHSAQKWIEAFQEGT 1051
>AK124904-1|BAC85990.1| 1430|Homo sapiens protein ( Homo sapiens cDNA
FLJ42914 fis, clone BRHIP3025161, weakly similar to
Rho/Rac guanine nucleotide exchange factor. ).
Length = 1430
Score = 33.1 bits (72), Expect = 2.7
Identities = 22/87 (25%), Positives = 38/87 (43%), Gaps = 8/87 (9%)
Query: 475 WQRYWLQMSGNMLFFYGAKSFKGTNRSDFRSERCKVLTLVGWIAVWADGDAADAFQLINH 534
W+ +W + +L+ Y A D + + L I V + + FQL+ H
Sbjct: 1350 WKHFWFVIKNKVLYTYAASE-------DVAALESQPLLGFTVIQVKDENSESKVFQLL-H 1401
Query: 535 HSGTVYKFKAGSEYAAKQWIAKIEEVT 561
+ Y FKA ++A++WI +E T
Sbjct: 1402 KNMLFYVFKAEDAHSAQKWIEAFQEGT 1428
>AK022666-1|BAB14165.1| 173|Homo sapiens protein ( Homo sapiens
cDNA FLJ12604 fis, clone NT2RM4001454. ).
Length = 173
Score = 33.1 bits (72), Expect = 2.7
Identities = 28/113 (24%), Positives = 47/113 (41%), Gaps = 4/113 (3%)
Query: 442 SNITKPEDIQCDFQGCVKRKTILKEGRKISLSSWQRYWLQMSGNMLFFYGAKSFKGTNRS 501
+N K + D Q ++ K K+ R + W+ + ++GN L F KS +
Sbjct: 43 NNPEKATVVNQDGQPLIEGKLKEKQVRWKFIKRWKTRYFTLAGNQLLFQKGKS--KDDPD 100
Query: 502 DFRSERCKVLTLVGWIAVWADGDAADAFQLINHHSGTVYKFKAGSEYAAKQWI 554
D E KV ++ D AF++ + Y FKA E A++W+
Sbjct: 101 DCPIELSKVQSVKAVAKKRRDRSLPRAFEIFTDNK--TYVFKAKDEKNAEEWL 151
>AK002045-1|BAA92052.1| 432|Homo sapiens protein ( Homo sapiens
cDNA FLJ11183 fis, clone PLACE1007488, weakly similar to
PUTATIVE RHO/RAC GUANINE NUCLEOTIDE EXCHANGE FACTOR. ).
Length = 432
Score = 33.1 bits (72), Expect = 2.7
Identities = 22/87 (25%), Positives = 38/87 (43%), Gaps = 8/87 (9%)
Query: 475 WQRYWLQMSGNMLFFYGAKSFKGTNRSDFRSERCKVLTLVGWIAVWADGDAADAFQLINH 534
W+ +W + +L+ Y A D + + L I V + + FQL+ H
Sbjct: 352 WKHFWFVIKNKVLYTYAASE-------DVAALESQPLLGFTVIQVKDENSESKVFQLL-H 403
Query: 535 HSGTVYKFKAGSEYAAKQWIAKIEEVT 561
+ Y FKA ++A++WI +E T
Sbjct: 404 KNMLFYVFKAEDAHSAQKWIEAFQEGT 430
>AB051479-1|BAB21783.1| 855|Homo sapiens KIAA1692 protein protein.
Length = 855
Score = 33.1 bits (72), Expect = 2.7
Identities = 28/113 (24%), Positives = 47/113 (41%), Gaps = 4/113 (3%)
Query: 442 SNITKPEDIQCDFQGCVKRKTILKEGRKISLSSWQRYWLQMSGNMLFFYGAKSFKGTNRS 501
+N K + D Q ++ K K+ R + W+ + ++GN L F KS +
Sbjct: 725 NNPEKATVVNQDGQPLIEGKLKEKQVRWKFIKRWKTRYFTLAGNQLLFQKGKS--KDDPD 782
Query: 502 DFRSERCKVLTLVGWIAVWADGDAADAFQLINHHSGTVYKFKAGSEYAAKQWI 554
D E KV ++ D AF++ + Y FKA E A++W+
Sbjct: 783 DCPIELSKVQSVKAVAKKRRDRSLPRAFEIFTDNK--TYVFKAKDEKNAEEWL 833
>BC014426-1|AAH14426.1| 351|Homo sapiens RGL3 protein protein.
Length = 351
Score = 32.7 bits (71), Expect = 3.6
Identities = 21/67 (31%), Positives = 33/67 (49%), Gaps = 3/67 (4%)
Query: 100 LRLSPDDVGNQLTLLDLPCFKAIKPEELTTCGWTKLNKLTVA---PNVVAFTKRFNRVSF 156
L S D+V QLTL+DL F ++ E W++ ++ A P V A +FN V+
Sbjct: 244 LDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTG 303
Query: 157 WTVQEIL 163
+ +L
Sbjct: 304 CVLGSVL 310
>AK027625-1|BAB55243.1| 833|Homo sapiens protein ( Homo sapiens
cDNA FLJ14719 fis, clone NT2RP3001457, weakly similar to
Drosophila melanogaster Melted (melt) mRNA. ).
Length = 833
Score = 32.3 bits (70), Expect = 4.8
Identities = 28/113 (24%), Positives = 46/113 (40%), Gaps = 4/113 (3%)
Query: 442 SNITKPEDIQCDFQGCVKRKTILKEGRKISLSSWQRYWLQMSGNMLFFYGAKSFKGTNRS 501
+N K + D Q ++ K K+ R + W+ + ++GN L F KS +
Sbjct: 703 NNPEKATVVNQDGQPLIEGKLKEKQVRWKFIKRWKTRYFTLAGNQLLFQKGKS--KDDPD 760
Query: 502 DFRSERCKVLTLVGWIAVWADGDAADAFQLINHHSGTVYKFKAGSEYAAKQWI 554
D E KV ++ D AF++ + Y FKA E A +W+
Sbjct: 761 DCPIELSKVQSVKAVAKKRRDRSLPRAFEIFTDNK--TYVFKAKDEKNAAEWL 811
>DQ310721-1|ABC40719.1| 606|Homo sapiens nei endonuclease VIII-like
3 (E. coli) protein.
Length = 606
Score = 31.5 bits (68), Expect = 8.4
Identities = 27/83 (32%), Positives = 38/83 (45%), Gaps = 5/83 (6%)
Query: 396 NIFGKSHTEDKMDEKTPAGSVNL-LDDTLLESPSSVACAKMSQSLPHSNITKPEDIQC-- 452
N FGK HTE K++ KT G+ L L D +S + K +Q L P C
Sbjct: 369 NTFGKPHTEVKINRKTAFGTTTLVLTDFSNKSSTLERKTKQNQILDEEFQNSPPASVCLN 428
Query: 453 DFQGCVKRKT--ILKEGRKISLS 473
D Q K+ T I + K+++S
Sbjct: 429 DIQHPSKKTTNDITQLSSKVNIS 451
>BC025954-1|AAH25954.1| 605|Homo sapiens nei endonuclease VIII-like
3 (E. coli) protein.
Length = 605
Score = 31.5 bits (68), Expect = 8.4
Identities = 27/83 (32%), Positives = 38/83 (45%), Gaps = 5/83 (6%)
Query: 396 NIFGKSHTEDKMDEKTPAGSVNL-LDDTLLESPSSVACAKMSQSLPHSNITKPEDIQC-- 452
N FGK HTE K++ KT G+ L L D +S + K +Q L P C
Sbjct: 368 NTFGKPHTEVKINRKTAFGTTTLVLTDFSNKSSTLERKTKQNQILDEEFQNSPPASVCLN 427
Query: 453 DFQGCVKRKT--ILKEGRKISLS 473
D Q K+ T I + K+++S
Sbjct: 428 DIQHPSKKTTNDITQLSSKVNIS 450
>AK001720-1|BAA91860.1| 605|Homo sapiens protein ( Homo sapiens
cDNA FLJ10858 fis, clone NT2RP4001555. ).
Length = 605
Score = 31.5 bits (68), Expect = 8.4
Identities = 27/83 (32%), Positives = 38/83 (45%), Gaps = 5/83 (6%)
Query: 396 NIFGKSHTEDKMDEKTPAGSVNL-LDDTLLESPSSVACAKMSQSLPHSNITKPEDIQC-- 452
N FGK HTE K++ KT G+ L L D +S + K +Q L P C
Sbjct: 368 NTFGKPHTEVKINRKTAFGTTTLVLTDFSNKSSTLERKTKQNQILDEEFQNSPPASVCLN 427
Query: 453 DFQGCVKRKT--ILKEGRKISLS 473
D Q K+ T I + K+++S
Sbjct: 428 DIQHPSKKTTNDITQLSSKVNIS 450
>AC110299-3|AAY14682.1| 300|Homo sapiens unknown protein.
Length = 300
Score = 31.5 bits (68), Expect = 8.4
Identities = 25/85 (29%), Positives = 39/85 (45%), Gaps = 9/85 (10%)
Query: 475 WQRYWLQMSGNMLFFYGAKSFKGTNRSDFRSERCKVLTLVGWIAVWADGDAAD-AFQLIN 533
WQ+ W+ + LFFY T++ D+ +L I ADG D F+L
Sbjct: 192 WQKLWVVFTNFCLFFY------KTHQDDYPLASLPLLGYSVSIPREADGIHKDYVFKL-- 243
Query: 534 HHSGTVYKFKAGSEYAAKQWIAKIE 558
VY F+A S+Y ++W+ I+
Sbjct: 244 QFKSHVYFFRAESKYTFERWMEVIQ 268
>AB079071-1|BAC06479.1| 605|Homo sapiens hypothetical protein
protein.
Length = 605
Score = 31.5 bits (68), Expect = 8.4
Identities = 27/83 (32%), Positives = 38/83 (45%), Gaps = 5/83 (6%)
Query: 396 NIFGKSHTEDKMDEKTPAGSVNL-LDDTLLESPSSVACAKMSQSLPHSNITKPEDIQC-- 452
N FGK HTE K++ KT G+ L L D +S + K +Q L P C
Sbjct: 368 NTFGKPHTEVKINRKTAFGTTTLVLTDFSNKSSTLERKTKQNQILDEEFQNSPPASVCLN 427
Query: 453 DFQGCVKRKT--ILKEGRKISLS 473
D Q K+ T I + K+++S
Sbjct: 428 DIQHPSKKTTNDITQLSSKVNIS 450
>AB018336-1|BAA34513.2| 1055|Homo sapiens KIAA0793 protein protein.
Length = 1055
Score = 31.5 bits (68), Expect = 8.4
Identities = 25/85 (29%), Positives = 39/85 (45%), Gaps = 9/85 (10%)
Query: 475 WQRYWLQMSGNMLFFYGAKSFKGTNRSDFRSERCKVLTLVGWIAVWADGDAAD-AFQLIN 533
WQ+ W+ + LFFY T++ D+ +L I ADG D F+L
Sbjct: 947 WQKLWVVFTNFCLFFY------KTHQDDYPLASLPLLGYSVSIPREADGIHKDYVFKL-- 998
Query: 534 HHSGTVYKFKAGSEYAAKQWIAKIE 558
VY F+A S+Y ++W+ I+
Sbjct: 999 QFKSHVYFFRAESKYTFERWMEVIQ 1023
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.318 0.132 0.407
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 90,954,835
Number of Sequences: 224733
Number of extensions: 3939307
Number of successful extensions: 8711
Number of sequences better than 10.0: 212
Number of HSP's better than 10.0 without gapping: 170
Number of HSP's successfully gapped in prelim test: 42
Number of HSP's that attempted gapping in prelim test: 8229
Number of HSP's gapped (non-prelim): 317
length of query: 576
length of database: 73,234,838
effective HSP length: 94
effective length of query: 482
effective length of database: 52,109,936
effective search space: 25116989152
effective search space used: 25116989152
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
S2: 68 (31.5 bits)
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