Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA000695-TA|BGIBMGA000695-PA|IPR001395|Aldo/keto reductase
(262 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
X15414-1|CAA33460.1| 316|Homo sapiens protein ( Human mRNA for ... 126 1e-28
M59783-1|AAA51712.1| 316|Homo sapiens aldose reductase protein. 126 1e-28
M34720-1|AAA35560.1| 316|Homo sapiens protein ( Human aldose re... 126 1e-28
J05474-1|AAA51715.1| 316|Homo sapiens aldose reductase protein. 126 1e-28
J05017-1|AAA51714.1| 316|Homo sapiens ALDR1 protein. 126 1e-28
J04795-1|AAA51713.1| 316|Homo sapiens ALDR1 protein. 126 1e-28
CR450351-1|CAG29347.1| 316|Homo sapiens AKR1B1 protein. 126 1e-28
BT019859-1|AAV38662.1| 316|Homo sapiens aldo-keto reductase fam... 126 1e-28
BC010391-1|AAH10391.1| 316|Homo sapiens aldo-keto reductase fam... 126 1e-28
BC000260-1|AAH00260.1| 316|Homo sapiens aldo-keto reductase fam... 126 1e-28
AF328729-1|AAN09721.1| 316|Homo sapiens CTCL tumor antigen HD-C... 126 1e-28
AF032455-1|AAB88851.1| 316|Homo sapiens aldose reductase protein. 126 1e-28
U37100-1|AAC17469.1| 316|Homo sapiens aldose reductase-like pep... 125 1e-28
CR541801-1|CAG46600.1| 316|Homo sapiens AKR1B10 protein. 125 1e-28
BT006794-1|AAP35440.1| 316|Homo sapiens aldo-keto reductase fam... 125 1e-28
BC008837-1|AAH08837.1| 316|Homo sapiens aldo-keto reductase fam... 125 1e-28
AF052577-1|AAC36465.1| 316|Homo sapiens aldo-keto reductase pro... 125 1e-28
CR542203-1|CAG47000.1| 316|Homo sapiens AKR1B1 protein. 125 2e-28
AF524864-1|AAO13380.1| 316|Homo sapiens aldo-ketoreductase prot... 122 1e-27
BC005387-1|AAH05387.1| 316|Homo sapiens aldo-keto reductase fam... 120 5e-27
U05861-1|AAA18115.1| 323|Homo sapiens hepatic dihydrodiol dehyd... 117 5e-26
U05684-1|AAA16227.1| 323|Homo sapiens dihydrodiol dehydrogenase... 117 5e-26
S68330-1|AAD14013.1| 323|Homo sapiens chlordecone reductase hom... 117 5e-26
M86609-1|AAB02880.1| 323|Homo sapiens dihydrodiol dehydrogenase... 117 5e-26
D26124-1|BAA05121.1| 306|Homo sapiens dihydrodiol dehydrogenase... 117 5e-26
BT007197-1|AAP35861.1| 323|Homo sapiens aldo-keto reductase fam... 117 5e-26
BC040210-1|AAH40210.1| 323|Homo sapiens aldo-keto reductase fam... 117 5e-26
BC020216-1|AAH20216.1| 323|Homo sapiens aldo-keto reductase fam... 117 5e-26
BC015490-1|AAH15490.1| 323|Homo sapiens aldo-keto reductase fam... 117 5e-26
AL713867-2|CAI16409.1| 323|Homo sapiens aldo-keto reductase fam... 117 5e-26
AB032150-1|BAA92886.1| 323|Homo sapiens 20 alph-hydroxysteroid ... 117 5e-26
AB031083-1|BAA92883.1| 323|Homo sapiens 20 alpha-hydroxysteroid... 117 5e-26
U05598-1|AAA20937.1| 323|Homo sapiens dihydrodiol dehydrogenase... 116 8e-26
BT006653-1|AAP35299.1| 323|Homo sapiens aldo-keto reductase fam... 116 8e-26
BC063574-1|AAH63574.1| 323|Homo sapiens aldo-keto reductase fam... 116 8e-26
BC007024-1|AAH07024.1| 323|Homo sapiens aldo-keto reductase fam... 116 8e-26
AL713867-1|CAI16408.1| 323|Homo sapiens aldo-keto reductase fam... 116 8e-26
AL391427-1|CAI14726.1| 323|Homo sapiens aldo-keto reductase fam... 116 8e-26
AB032153-1|BAA92891.1| 323|Homo sapiens bile acid-binding prote... 116 8e-26
AB031084-1|BAA92884.1| 323|Homo sapiens bile acid-binding prote... 116 8e-26
AB021654-1|BAA36169.1| 323|Homo sapiens DD2/bile acid-binding p... 116 8e-26
L32592-1|AAB38486.1| 323|Homo sapiens dihydrodiol dehydrogenase... 115 1e-25
S68290-1|AAD14012.1| 320|Homo sapiens chlordecone reductase hom... 115 2e-25
AL355303-2|CAI14202.1| 323|Homo sapiens aldo-keto reductase fam... 114 3e-25
S68287-1|AAD14010.1| 323|Homo sapiens chlordecone reductase pro... 113 4e-25
M33375-1|AAA35658.1| 308|Homo sapiens protein ( Human chlordeco... 113 4e-25
D26125-1|BAA05122.1| 321|Homo sapiens 3 alpha-hydroxysteroid/di... 113 4e-25
BC020744-1|AAH20744.1| 323|Homo sapiens aldo-keto reductase fam... 113 4e-25
AB045829-1|BAA99542.1| 323|Homo sapiens 3alpha-hydroxysteroid d... 113 4e-25
AB032163-1|BAA92893.1| 323|Homo sapiens dihydrodiol dehydrogena... 113 4e-25
AB031085-1|BAA92885.1| 323|Homo sapiens dihydrodiol dehydrogena... 113 4e-25
AL713867-3|CAI16410.1| 247|Homo sapiens aldo-keto reductase fam... 111 2e-24
J04794-1|AAA51711.1| 325|Homo sapiens ALDR1 protein. 111 2e-24
CR457010-1|CAG33291.1| 325|Homo sapiens AKR1A1 protein. 111 2e-24
BT007003-1|AAP35649.1| 325|Homo sapiens aldo-keto reductase fam... 111 2e-24
BC005394-1|AAH05394.1| 325|Homo sapiens aldo-keto reductase fam... 111 2e-24
BC000670-1|AAH00670.1| 325|Homo sapiens aldo-keto reductase fam... 111 2e-24
AL355480-3|CAI22459.1| 325|Homo sapiens aldo-keto reductase fam... 111 2e-24
AF112485-1|AAF01260.1| 325|Homo sapiens aldehyde reductase prot... 111 2e-24
AF036683-1|AAB92369.1| 325|Homo sapiens aldehyde reductase prot... 111 2e-24
Z28339-1|CAA82193.1| 326|Homo sapiens delta 4-3-oxosteroid 5 be... 111 3e-24
DQ269985-1|ABB76132.1| 323|Homo sapiens type II 3a-hydroxystero... 111 3e-24
BC130627-1|AAI30628.1| 326|Homo sapiens aldo-keto reductase fam... 111 3e-24
BC130625-1|AAI30626.1| 326|Homo sapiens aldo-keto reductase fam... 111 3e-24
AF283659-1|AAG39381.1| 326|Homo sapiens 5-beta steroid reductas... 111 3e-24
D17793-1|BAA04619.2| 325|Homo sapiens KIAA0119 protein. 109 7e-24
BT007286-1|AAP35950.1| 323|Homo sapiens aldo-keto reductase fam... 109 7e-24
BC019230-1|AAH19230.1| 323|Homo sapiens aldo-keto reductase fam... 109 7e-24
BC001479-1|AAH01479.1| 323|Homo sapiens aldo-keto reductase fam... 109 7e-24
AL391427-4|CAI14729.1| 323|Homo sapiens aldo-keto reductase fam... 109 7e-24
AF149416-1|AAF07272.2| 323|Homo sapiens 3-alpha hydroxysteroid ... 109 7e-24
AB032157-1|BAA92892.1| 323|Homo sapiens prostaglandin F synthas... 109 7e-24
AB018580-1|BAA88488.1| 323|Homo sapiens hluPGFS protein. 109 7e-24
S68288-1|AAD14011.1| 323|Homo sapiens chlordecone reductase hom... 109 1e-23
L43839-1|AAB41916.1| 323|Homo sapiens 3-alpha-hydroxysteroid de... 109 1e-23
BC002862-1|AAH02862.1| 307|Homo sapiens AKR1CL2 protein protein. 103 6e-22
AF263242-1|AAK58523.1| 320|Homo sapiens aldo-keto reductase loo... 103 6e-22
AB055603-1|BAC54568.1| 307|Homo sapiens aldo-keto reductase rel... 103 6e-22
AB209796-1|BAD93033.1| 260|Homo sapiens aldo-keto reductase fam... 95 2e-19
AL391427-2|CAI14727.1| 302|Homo sapiens aldo-keto reductase fam... 87 8e-17
AL355303-1|CAI14201.1| 302|Homo sapiens aldo-keto reductase fam... 87 8e-17
AB209017-1|BAD92254.1| 286|Homo sapiens aldo-keto reductase fam... 86 1e-16
AK058142-1|BAB71682.1| 146|Homo sapiens protein ( Homo sapiens ... 63 8e-10
AF044961-1|AAC15671.1| 85|Homo sapiens aldose reductase-relate... 44 7e-04
AB040822-1|BAC54567.1| 222|Homo sapiens aldo-keto reductase rel... 41 0.004
AB040821-1|BAC54566.1| 263|Homo sapiens aldo-keto reductase rel... 41 0.004
AB040820-1|BAC54565.1| 250|Homo sapiens aldo-keto reductase rel... 41 0.004
AL355480-2|CAI22458.1| 147|Homo sapiens aldo-keto reductase fam... 37 0.062
AF040639-1|AAD02195.1| 331|Homo sapiens aflatoxin B1-aldehyde r... 36 0.19
BC042420-1|AAH42420.2| 331|Homo sapiens aldo-keto reductase fam... 35 0.25
BC031562-1|AAH31562.1| 331|Homo sapiens aldo-keto reductase fam... 35 0.25
AJ271799-1|CAC81076.1| 331|Homo sapiens aflatoxin B1 aldehyde r... 35 0.25
BC025709-1|AAH25709.1| 331|Homo sapiens aldo-keto reductase fam... 35 0.33
AL035413-11|CAI22232.1| 331|Homo sapiens aldo-keto reductase fa... 35 0.33
AB037905-2|BAA92890.1| 45|Homo sapiens truncated aldo-keto red... 32 1.8
AB037902-1|BAA92887.1| 130|Homo sapiens truncated aldo-keto red... 32 1.8
Y16675-1|CAA76347.1| 330|Homo sapiens aflatoxin B1-aldehyde red... 32 2.3
BT007347-1|AAP36011.1| 330|Homo sapiens aldo-keto reductase fam... 32 2.3
BC013996-1|AAH13996.1| 330|Homo sapiens AKR7A2 protein protein. 32 2.3
BC012171-1|AAH12171.1| 330|Homo sapiens AKR7A2 protein protein. 32 2.3
BC011586-1|AAH11586.1| 330|Homo sapiens AKR7A2 protein protein. 32 2.3
BC010852-1|AAH10852.1| 330|Homo sapiens AKR7A2 protein protein. 32 2.3
BC007352-1|AAH07352.2| 358|Homo sapiens AKR7A2 protein protein. 32 2.3
BC004111-1|AAH04111.3| 330|Homo sapiens AKR7A2 protein protein. 32 2.3
AL035413-8|CAB72321.1| 330|Homo sapiens aldo-keto reductase fam... 32 2.3
AJ278012-1|CAC79668.1| 259|Homo sapiens aflatoxin B1 aldehyde r... 32 2.3
AF026947-1|AAC52104.1| 330|Homo sapiens aflatoxin aldehyde redu... 32 2.3
>X15414-1|CAA33460.1| 316|Homo sapiens protein ( Human mRNA for
aldose reductase (EC 1.1.1.2). ).
Length = 316
Score = 126 bits (303), Expect = 1e-28
Identities = 76/199 (38%), Positives = 113/199 (56%), Gaps = 18/199 (9%)
Query: 63 AYQKSLENLDLEYVDLYLIHFPGGAK-----LPAEDKRNTKMRELS----WCKLTELYDD 113
A QK+L +L L+Y+DLYLIH+P G K P ++ N + + W + EL D+
Sbjct: 92 ACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDE 151
Query: 114 GKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSLYKFCKQHHITLQAY 171
G V A+G+SNF +E ++ + GL PAVNQ+E HPY TQ L ++C+ I + AY
Sbjct: 152 GLVKAIGISNFNHLQVEMIL-NKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAY 210
Query: 172 CSFGG-----TSCSNNSLLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKAVHPEHI 226
G + SLL DP + + A K T AQVL+ + +Q+++ VIPK+V PE I
Sbjct: 211 SPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERI 270
Query: 227 KEN-RSLNFKIPEEDMKAL 244
EN + +F++ +DM L
Sbjct: 271 AENFKVFDFELSSQDMTTL 289
Score = 34.3 bits (75), Expect = 0.44
Identities = 16/37 (43%), Positives = 23/37 (62%), Gaps = 1/37 (2%)
Query: 13 VLNNGIMMPSIGLGTYRIRQSDIVMQVVDYALEAGYR 49
+LNNG MP +GLGT++ V + V A++ GYR
Sbjct: 6 LLNNGAKMPILGLGTWKSPPGQ-VTEAVKVAIDVGYR 41
>M59783-1|AAA51712.1| 316|Homo sapiens aldose reductase protein.
Length = 316
Score = 126 bits (303), Expect = 1e-28
Identities = 76/199 (38%), Positives = 113/199 (56%), Gaps = 18/199 (9%)
Query: 63 AYQKSLENLDLEYVDLYLIHFPGGAK-----LPAEDKRNTKMRELS----WCKLTELYDD 113
A QK+L +L L+Y+DLYLIH+P G K P ++ N + + W + EL D+
Sbjct: 92 ACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDE 151
Query: 114 GKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSLYKFCKQHHITLQAY 171
G V A+G+SNF +E ++ + GL PAVNQ+E HPY TQ L ++C+ I + AY
Sbjct: 152 GLVKAIGISNFNHLQVEMIL-NKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAY 210
Query: 172 CSFGG-----TSCSNNSLLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKAVHPEHI 226
G + SLL DP + + A K T AQVL+ + +Q+++ VIPK+V PE I
Sbjct: 211 SPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERI 270
Query: 227 KEN-RSLNFKIPEEDMKAL 244
EN + +F++ +DM L
Sbjct: 271 AENFKVFDFELSSQDMTTL 289
Score = 34.3 bits (75), Expect = 0.44
Identities = 16/37 (43%), Positives = 23/37 (62%), Gaps = 1/37 (2%)
Query: 13 VLNNGIMMPSIGLGTYRIRQSDIVMQVVDYALEAGYR 49
+LNNG MP +GLGT++ V + V A++ GYR
Sbjct: 6 LLNNGAKMPILGLGTWKSPPGQ-VTEAVKVAIDVGYR 41
>M34720-1|AAA35560.1| 316|Homo sapiens protein ( Human aldose
reductase mRNA, complete cds. ).
Length = 316
Score = 126 bits (303), Expect = 1e-28
Identities = 76/199 (38%), Positives = 113/199 (56%), Gaps = 18/199 (9%)
Query: 63 AYQKSLENLDLEYVDLYLIHFPGGAK-----LPAEDKRNTKMRELS----WCKLTELYDD 113
A QK+L +L L+Y+DLYLIH+P G K P ++ N + + W + EL D+
Sbjct: 92 ACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDE 151
Query: 114 GKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSLYKFCKQHHITLQAY 171
G V A+G+SNF +E ++ + GL PAVNQ+E HPY TQ L ++C+ I + AY
Sbjct: 152 GLVKAIGISNFNHLQVEMIL-NKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAY 210
Query: 172 CSFGG-----TSCSNNSLLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKAVHPEHI 226
G + SLL DP + + A K T AQVL+ + +Q+++ VIPK+V PE I
Sbjct: 211 SPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERI 270
Query: 227 KEN-RSLNFKIPEEDMKAL 244
EN + +F++ +DM L
Sbjct: 271 AENFKVFDFELSSQDMTTL 289
Score = 34.3 bits (75), Expect = 0.44
Identities = 16/37 (43%), Positives = 23/37 (62%), Gaps = 1/37 (2%)
Query: 13 VLNNGIMMPSIGLGTYRIRQSDIVMQVVDYALEAGYR 49
+LNNG MP +GLGT++ V + V A++ GYR
Sbjct: 6 LLNNGAKMPILGLGTWKSPPGQ-VTEAVKVAIDVGYR 41
>J05474-1|AAA51715.1| 316|Homo sapiens aldose reductase protein.
Length = 316
Score = 126 bits (303), Expect = 1e-28
Identities = 76/199 (38%), Positives = 113/199 (56%), Gaps = 18/199 (9%)
Query: 63 AYQKSLENLDLEYVDLYLIHFPGGAK-----LPAEDKRNTKMRELS----WCKLTELYDD 113
A QK+L +L L+Y+DLYLIH+P G K P ++ N + + W + EL D+
Sbjct: 92 ACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDE 151
Query: 114 GKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSLYKFCKQHHITLQAY 171
G V A+G+SNF +E ++ + GL PAVNQ+E HPY TQ L ++C+ I + AY
Sbjct: 152 GLVKAIGISNFNHLQVEMIL-NKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAY 210
Query: 172 CSFGG-----TSCSNNSLLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKAVHPEHI 226
G + SLL DP + + A K T AQVL+ + +Q+++ VIPK+V PE I
Sbjct: 211 SPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERI 270
Query: 227 KEN-RSLNFKIPEEDMKAL 244
EN + +F++ +DM L
Sbjct: 271 AENFKVFDFELSSQDMTTL 289
Score = 34.3 bits (75), Expect = 0.44
Identities = 16/37 (43%), Positives = 23/37 (62%), Gaps = 1/37 (2%)
Query: 13 VLNNGIMMPSIGLGTYRIRQSDIVMQVVDYALEAGYR 49
+LNNG MP +GLGT++ V + V A++ GYR
Sbjct: 6 LLNNGAKMPILGLGTWKSPPGQ-VTEAVKVAIDVGYR 41
>J05017-1|AAA51714.1| 316|Homo sapiens ALDR1 protein.
Length = 316
Score = 126 bits (303), Expect = 1e-28
Identities = 76/199 (38%), Positives = 113/199 (56%), Gaps = 18/199 (9%)
Query: 63 AYQKSLENLDLEYVDLYLIHFPGGAK-----LPAEDKRNTKMRELS----WCKLTELYDD 113
A QK+L +L L+Y+DLYLIH+P G K P ++ N + + W + EL D+
Sbjct: 92 ACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDE 151
Query: 114 GKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSLYKFCKQHHITLQAY 171
G V A+G+SNF +E ++ + GL PAVNQ+E HPY TQ L ++C+ I + AY
Sbjct: 152 GLVKAIGISNFNHLQVEMIL-NKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAY 210
Query: 172 CSFGG-----TSCSNNSLLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKAVHPEHI 226
G + SLL DP + + A K T AQVL+ + +Q+++ VIPK+V PE I
Sbjct: 211 SPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERI 270
Query: 227 KEN-RSLNFKIPEEDMKAL 244
EN + +F++ +DM L
Sbjct: 271 AENFKVFDFELSSQDMTTL 289
Score = 34.3 bits (75), Expect = 0.44
Identities = 16/37 (43%), Positives = 23/37 (62%), Gaps = 1/37 (2%)
Query: 13 VLNNGIMMPSIGLGTYRIRQSDIVMQVVDYALEAGYR 49
+LNNG MP +GLGT++ V + V A++ GYR
Sbjct: 6 LLNNGAKMPILGLGTWKSPPGQ-VTEAVKVAIDVGYR 41
>J04795-1|AAA51713.1| 316|Homo sapiens ALDR1 protein.
Length = 316
Score = 126 bits (303), Expect = 1e-28
Identities = 76/199 (38%), Positives = 113/199 (56%), Gaps = 18/199 (9%)
Query: 63 AYQKSLENLDLEYVDLYLIHFPGGAK-----LPAEDKRNTKMRELS----WCKLTELYDD 113
A QK+L +L L+Y+DLYLIH+P G K P ++ N + + W + EL D+
Sbjct: 92 ACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDE 151
Query: 114 GKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSLYKFCKQHHITLQAY 171
G V A+G+SNF +E ++ + GL PAVNQ+E HPY TQ L ++C+ I + AY
Sbjct: 152 GLVKAIGISNFNHLQVEMIL-NKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAY 210
Query: 172 CSFGG-----TSCSNNSLLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKAVHPEHI 226
G + SLL DP + + A K T AQVL+ + +Q+++ VIPK+V PE I
Sbjct: 211 SPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERI 270
Query: 227 KEN-RSLNFKIPEEDMKAL 244
EN + +F++ +DM L
Sbjct: 271 AENFKVFDFELSSQDMTTL 289
Score = 34.3 bits (75), Expect = 0.44
Identities = 16/37 (43%), Positives = 23/37 (62%), Gaps = 1/37 (2%)
Query: 13 VLNNGIMMPSIGLGTYRIRQSDIVMQVVDYALEAGYR 49
+LNNG MP +GLGT++ V + V A++ GYR
Sbjct: 6 LLNNGAKMPILGLGTWKSPPGQ-VTEAVKVAIDVGYR 41
>CR450351-1|CAG29347.1| 316|Homo sapiens AKR1B1 protein.
Length = 316
Score = 126 bits (303), Expect = 1e-28
Identities = 76/199 (38%), Positives = 113/199 (56%), Gaps = 18/199 (9%)
Query: 63 AYQKSLENLDLEYVDLYLIHFPGGAK-----LPAEDKRNTKMRELS----WCKLTELYDD 113
A QK+L +L L+Y+DLYLIH+P G + P ++ N + + W + EL D+
Sbjct: 92 ACQKTLSDLKLDYLDLYLIHWPTGFRPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDE 151
Query: 114 GKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSLYKFCKQHHITLQAY 171
G V A+G+SNF +E ++ S GL PAVNQ+E HPY TQ L ++C+ I + AY
Sbjct: 152 GLVKAIGISNFNHLQVEMIL-SKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAY 210
Query: 172 CSFGG-----TSCSNNSLLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKAVHPEHI 226
G + SLL DP + + A K T AQVL+ + +Q+++ VIPK+V PE I
Sbjct: 211 SPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERI 270
Query: 227 KEN-RSLNFKIPEEDMKAL 244
EN + +F++ +DM L
Sbjct: 271 AENFKVFDFELSSQDMTTL 289
Score = 34.3 bits (75), Expect = 0.44
Identities = 16/37 (43%), Positives = 23/37 (62%), Gaps = 1/37 (2%)
Query: 13 VLNNGIMMPSIGLGTYRIRQSDIVMQVVDYALEAGYR 49
+LNNG MP +GLGT++ V + V A++ GYR
Sbjct: 6 LLNNGAKMPILGLGTWKSPPGQ-VTEAVKVAIDVGYR 41
>BT019859-1|AAV38662.1| 316|Homo sapiens aldo-keto reductase family
1, member B1 (aldose reductase) protein.
Length = 316
Score = 126 bits (303), Expect = 1e-28
Identities = 76/199 (38%), Positives = 113/199 (56%), Gaps = 18/199 (9%)
Query: 63 AYQKSLENLDLEYVDLYLIHFPGGAK-----LPAEDKRNTKMRELS----WCKLTELYDD 113
A QK+L +L L+Y+DLYLIH+P G K P ++ N + + W + EL D+
Sbjct: 92 ACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDE 151
Query: 114 GKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSLYKFCKQHHITLQAY 171
G V A+G+SNF +E ++ + GL PAVNQ+E HPY TQ L ++C+ I + AY
Sbjct: 152 GLVKAIGISNFNHLQVEMIL-NKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAY 210
Query: 172 CSFGG-----TSCSNNSLLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKAVHPEHI 226
G + SLL DP + + A K T AQVL+ + +Q+++ VIPK+V PE I
Sbjct: 211 SPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERI 270
Query: 227 KEN-RSLNFKIPEEDMKAL 244
EN + +F++ +DM L
Sbjct: 271 AENFKVFDFELSSQDMTTL 289
Score = 34.3 bits (75), Expect = 0.44
Identities = 16/37 (43%), Positives = 23/37 (62%), Gaps = 1/37 (2%)
Query: 13 VLNNGIMMPSIGLGTYRIRQSDIVMQVVDYALEAGYR 49
+LNNG MP +GLGT++ V + V A++ GYR
Sbjct: 6 LLNNGAKMPILGLGTWKSPPGQ-VTEAVKVAIDVGYR 41
>BC010391-1|AAH10391.1| 316|Homo sapiens aldo-keto reductase family
1, member B1 (aldose reductase) protein.
Length = 316
Score = 126 bits (303), Expect = 1e-28
Identities = 76/199 (38%), Positives = 113/199 (56%), Gaps = 18/199 (9%)
Query: 63 AYQKSLENLDLEYVDLYLIHFPGGAK-----LPAEDKRNTKMRELS----WCKLTELYDD 113
A QK+L +L L+Y+DLYLIH+P G K P ++ N + + W + EL D+
Sbjct: 92 ACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDE 151
Query: 114 GKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSLYKFCKQHHITLQAY 171
G V A+G+SNF +E ++ + GL PAVNQ+E HPY TQ L ++C+ I + AY
Sbjct: 152 GLVKAIGISNFNHLQVEMIL-NKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAY 210
Query: 172 CSFGG-----TSCSNNSLLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKAVHPEHI 226
G + SLL DP + + A K T AQVL+ + +Q+++ VIPK+V PE I
Sbjct: 211 SPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERI 270
Query: 227 KEN-RSLNFKIPEEDMKAL 244
EN + +F++ +DM L
Sbjct: 271 AENFKVFDFELSSQDMTTL 289
Score = 34.3 bits (75), Expect = 0.44
Identities = 16/37 (43%), Positives = 23/37 (62%), Gaps = 1/37 (2%)
Query: 13 VLNNGIMMPSIGLGTYRIRQSDIVMQVVDYALEAGYR 49
+LNNG MP +GLGT++ V + V A++ GYR
Sbjct: 6 LLNNGAKMPILGLGTWKSPPGQ-VTEAVKVAIDVGYR 41
>BC000260-1|AAH00260.1| 316|Homo sapiens aldo-keto reductase family
1, member B1 (aldose reductase) protein.
Length = 316
Score = 126 bits (303), Expect = 1e-28
Identities = 76/199 (38%), Positives = 113/199 (56%), Gaps = 18/199 (9%)
Query: 63 AYQKSLENLDLEYVDLYLIHFPGGAK-----LPAEDKRNTKMRELS----WCKLTELYDD 113
A QK+L +L L+Y+DLYLIH+P G K P ++ N + + W + EL D+
Sbjct: 92 ACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDE 151
Query: 114 GKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSLYKFCKQHHITLQAY 171
G V A+G+SNF +E ++ + GL PAVNQ+E HPY TQ L ++C+ I + AY
Sbjct: 152 GLVKAIGISNFNHLQVEMIL-NKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAY 210
Query: 172 CSFGG-----TSCSNNSLLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKAVHPEHI 226
G + SLL DP + + A K T AQVL+ + +Q+++ VIPK+V PE I
Sbjct: 211 SPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERI 270
Query: 227 KEN-RSLNFKIPEEDMKAL 244
EN + +F++ +DM L
Sbjct: 271 AENFKVFDFELSSQDMTTL 289
Score = 34.3 bits (75), Expect = 0.44
Identities = 16/37 (43%), Positives = 23/37 (62%), Gaps = 1/37 (2%)
Query: 13 VLNNGIMMPSIGLGTYRIRQSDIVMQVVDYALEAGYR 49
+LNNG MP +GLGT++ V + V A++ GYR
Sbjct: 6 LLNNGAKMPILGLGTWKSPPGQ-VTEAVKVAIDVGYR 41
>AF328729-1|AAN09721.1| 316|Homo sapiens CTCL tumor antigen
HD-CL-07 protein.
Length = 316
Score = 126 bits (303), Expect = 1e-28
Identities = 76/199 (38%), Positives = 113/199 (56%), Gaps = 18/199 (9%)
Query: 63 AYQKSLENLDLEYVDLYLIHFPGGAK-----LPAEDKRNTKMRELS----WCKLTELYDD 113
A QK+L +L L+Y+DLYLIH+P G K P ++ N + + W + EL D+
Sbjct: 92 ACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDE 151
Query: 114 GKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSLYKFCKQHHITLQAY 171
G V A+G+SNF +E ++ + GL PAVNQ+E HPY TQ L ++C+ I + AY
Sbjct: 152 GLVKAIGISNFNHLQVEMIL-NKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAY 210
Query: 172 CSFGG-----TSCSNNSLLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKAVHPEHI 226
G + SLL DP + + A K T AQVL+ + +Q+++ VIPK+V PE I
Sbjct: 211 SPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERI 270
Query: 227 KEN-RSLNFKIPEEDMKAL 244
EN + +F++ +DM L
Sbjct: 271 AENFKVFDFELSSQDMTTL 289
Score = 34.3 bits (75), Expect = 0.44
Identities = 16/37 (43%), Positives = 23/37 (62%), Gaps = 1/37 (2%)
Query: 13 VLNNGIMMPSIGLGTYRIRQSDIVMQVVDYALEAGYR 49
+LNNG MP +GLGT++ V + V A++ GYR
Sbjct: 6 LLNNGAKMPILGLGTWKSPPGQ-VTEAVKVAIDVGYR 41
>AF032455-1|AAB88851.1| 316|Homo sapiens aldose reductase protein.
Length = 316
Score = 126 bits (303), Expect = 1e-28
Identities = 76/199 (38%), Positives = 113/199 (56%), Gaps = 18/199 (9%)
Query: 63 AYQKSLENLDLEYVDLYLIHFPGGAK-----LPAEDKRNTKMRELS----WCKLTELYDD 113
A QK+L +L L+Y+DLYLIH+P G K P ++ N + + W + EL D+
Sbjct: 92 ACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDE 151
Query: 114 GKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSLYKFCKQHHITLQAY 171
G V A+G+SNF +E ++ + GL PAVNQ+E HPY TQ L ++C+ I + AY
Sbjct: 152 GLVKAIGISNFNHLQVEMIL-NKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAY 210
Query: 172 CSFGG-----TSCSNNSLLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKAVHPEHI 226
G + SLL DP + + A K T AQVL+ + +Q+++ VIPK+V PE I
Sbjct: 211 SPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERI 270
Query: 227 KEN-RSLNFKIPEEDMKAL 244
EN + +F++ +DM L
Sbjct: 271 AENFKVFDFELSSQDMTTL 289
Score = 34.3 bits (75), Expect = 0.44
Identities = 16/37 (43%), Positives = 23/37 (62%), Gaps = 1/37 (2%)
Query: 13 VLNNGIMMPSIGLGTYRIRQSDIVMQVVDYALEAGYR 49
+LNNG MP +GLGT++ V + V A++ GYR
Sbjct: 6 LLNNGAKMPILGLGTWKSPPGQ-VTEAVKVAIDVGYR 41
>U37100-1|AAC17469.1| 316|Homo sapiens aldose reductase-like
peptide protein.
Length = 316
Score = 125 bits (302), Expect = 1e-28
Identities = 80/200 (40%), Positives = 116/200 (58%), Gaps = 18/200 (9%)
Query: 62 QAYQKSLENLDLEYVDLYLIHFPGGAK-----LPAEDKRNT---KMREL-SWCKLTELYD 112
+A++K+L++L L Y+D+YLIH+P G K P +DK N K L +W + EL D
Sbjct: 91 KAFEKTLKDLKLSYLDVYLIHWPQGFKSGDDLFPKDDKGNAIGGKATFLDAWEAMEELVD 150
Query: 113 DGKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSLYKFCKQHHITLQA 170
+G V A+GVSNF+ +E L+ + GL P NQVE HPY TQ L ++C IT+ A
Sbjct: 151 EGLVKALGVSNFSHFQIEKLL-NKPGLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTA 209
Query: 171 YCSFGG-----TSCSNNSLLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKAVHPEH 225
Y G + SLL DP + A K + T AQVL+ + +Q++V VIPK+V P
Sbjct: 210 YSPLGSPDRPWAKPEDPSLLEDPKIKEIAAKHKKTAAQVLIRFHIQRNVIVIPKSVTPAR 269
Query: 226 IKEN-RSLNFKIPEEDMKAL 244
I EN + +FK+ +E+M +
Sbjct: 270 IVENIQVFDFKLSDEEMATI 289
>CR541801-1|CAG46600.1| 316|Homo sapiens AKR1B10 protein.
Length = 316
Score = 125 bits (302), Expect = 1e-28
Identities = 80/200 (40%), Positives = 116/200 (58%), Gaps = 18/200 (9%)
Query: 62 QAYQKSLENLDLEYVDLYLIHFPGGAK-----LPAEDKRNT---KMREL-SWCKLTELYD 112
+A++K+L++L L Y+D+YLIH+P G K P +DK N K L +W + EL D
Sbjct: 91 KAFEKTLKDLKLSYLDVYLIHWPQGFKSGDDLFPKDDKGNAIGGKATFLDAWEAMEELVD 150
Query: 113 DGKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSLYKFCKQHHITLQA 170
+G V A+GVSNF+ +E L+ + GL P NQVE HPY TQ L ++C IT+ A
Sbjct: 151 EGLVKALGVSNFSHFQIEKLL-NKPGLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTA 209
Query: 171 YCSFGG-----TSCSNNSLLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKAVHPEH 225
Y G + SLL DP + A K + T AQVL+ + +Q++V VIPK+V P
Sbjct: 210 YSPLGSPDRPWAKPEDPSLLEDPKIKEIAAKHKKTAAQVLIRFHIQRNVIVIPKSVTPAR 269
Query: 226 IKEN-RSLNFKIPEEDMKAL 244
I EN + +FK+ +E+M +
Sbjct: 270 IVENIQVFDFKLSDEEMATI 289
>BT006794-1|AAP35440.1| 316|Homo sapiens aldo-keto reductase family
1, member B10 (aldose reductase) protein.
Length = 316
Score = 125 bits (302), Expect = 1e-28
Identities = 80/200 (40%), Positives = 116/200 (58%), Gaps = 18/200 (9%)
Query: 62 QAYQKSLENLDLEYVDLYLIHFPGGAK-----LPAEDKRNT---KMREL-SWCKLTELYD 112
+A++K+L++L L Y+D+YLIH+P G K P +DK N K L +W + EL D
Sbjct: 91 KAFEKTLKDLKLSYLDVYLIHWPQGFKSGDDLFPKDDKGNAIGGKATFLDAWEAMEELVD 150
Query: 113 DGKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSLYKFCKQHHITLQA 170
+G V A+GVSNF+ +E L+ + GL P NQVE HPY TQ L ++C IT+ A
Sbjct: 151 EGLVKALGVSNFSHFQIEKLL-NKPGLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTA 209
Query: 171 YCSFGG-----TSCSNNSLLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKAVHPEH 225
Y G + SLL DP + A K + T AQVL+ + +Q++V VIPK+V P
Sbjct: 210 YSPLGSPDRPWAKPEDPSLLEDPKIKEIAAKHKKTAAQVLIRFHIQRNVIVIPKSVTPAR 269
Query: 226 IKEN-RSLNFKIPEEDMKAL 244
I EN + +FK+ +E+M +
Sbjct: 270 IVENIQVFDFKLSDEEMATI 289
>BC008837-1|AAH08837.1| 316|Homo sapiens aldo-keto reductase family
1, member B10 (aldose reductase) protein.
Length = 316
Score = 125 bits (302), Expect = 1e-28
Identities = 80/200 (40%), Positives = 116/200 (58%), Gaps = 18/200 (9%)
Query: 62 QAYQKSLENLDLEYVDLYLIHFPGGAK-----LPAEDKRNT---KMREL-SWCKLTELYD 112
+A++K+L++L L Y+D+YLIH+P G K P +DK N K L +W + EL D
Sbjct: 91 KAFEKTLKDLKLSYLDVYLIHWPQGFKSGDDLFPKDDKGNAIGGKATFLDAWEAMEELVD 150
Query: 113 DGKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSLYKFCKQHHITLQA 170
+G V A+GVSNF+ +E L+ + GL P NQVE HPY TQ L ++C IT+ A
Sbjct: 151 EGLVKALGVSNFSHFQIEKLL-NKPGLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTA 209
Query: 171 YCSFGG-----TSCSNNSLLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKAVHPEH 225
Y G + SLL DP + A K + T AQVL+ + +Q++V VIPK+V P
Sbjct: 210 YSPLGSPDRPWAKPEDPSLLEDPKIKEIAAKHKKTAAQVLIRFHIQRNVIVIPKSVTPAR 269
Query: 226 IKEN-RSLNFKIPEEDMKAL 244
I EN + +FK+ +E+M +
Sbjct: 270 IVENIQVFDFKLSDEEMATI 289
>AF052577-1|AAC36465.1| 316|Homo sapiens aldo-keto reductase
protein.
Length = 316
Score = 125 bits (302), Expect = 1e-28
Identities = 80/200 (40%), Positives = 116/200 (58%), Gaps = 18/200 (9%)
Query: 62 QAYQKSLENLDLEYVDLYLIHFPGGAK-----LPAEDKRNT---KMREL-SWCKLTELYD 112
+A++K+L++L L Y+D+YLIH+P G K P +DK N K L +W + EL D
Sbjct: 91 KAFEKTLKDLKLSYLDVYLIHWPQGFKSGDDLFPKDDKGNAIGGKATFLDAWEAMEELVD 150
Query: 113 DGKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSLYKFCKQHHITLQA 170
+G V A+GVSNF+ +E L+ + GL P NQVE HPY TQ L ++C IT+ A
Sbjct: 151 EGLVKALGVSNFSHFQIEKLL-NKPGLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTA 209
Query: 171 YCSFGG-----TSCSNNSLLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKAVHPEH 225
Y G + SLL DP + A K + T AQVL+ + +Q++V VIPK+V P
Sbjct: 210 YSPLGSPDRPWAKPEDPSLLEDPKIKEIAAKHKKTAAQVLIRFHIQRNVIVIPKSVTPAR 269
Query: 226 IKEN-RSLNFKIPEEDMKAL 244
I EN + +FK+ +E+M +
Sbjct: 270 IVENIQVFDFKLSDEEMATI 289
>CR542203-1|CAG47000.1| 316|Homo sapiens AKR1B1 protein.
Length = 316
Score = 125 bits (301), Expect = 2e-28
Identities = 76/199 (38%), Positives = 113/199 (56%), Gaps = 18/199 (9%)
Query: 63 AYQKSLENLDLEYVDLYLIHFPGGAK-----LPAEDKRNTKMRELS----WCKLTELYDD 113
A QK+L +L L+Y+DLYLIH+P G K P ++ N + + W + EL D+
Sbjct: 92 ACQKTLSDLKLDYLDLYLIHWPIGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDE 151
Query: 114 GKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSLYKFCKQHHITLQAY 171
G V A+G+SNF +E ++ + GL PAVNQ+E HPY TQ L ++C+ I + AY
Sbjct: 152 GLVKAIGISNFNHLQVEMIL-NKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAY 210
Query: 172 CSFGG-----TSCSNNSLLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKAVHPEHI 226
G + SLL DP + + A K T AQVL+ + +Q+++ VIPK+V PE I
Sbjct: 211 SPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERI 270
Query: 227 KEN-RSLNFKIPEEDMKAL 244
EN + +F++ +DM L
Sbjct: 271 AENFKVFDFELSSQDMTTL 289
Score = 34.3 bits (75), Expect = 0.44
Identities = 16/37 (43%), Positives = 23/37 (62%), Gaps = 1/37 (2%)
Query: 13 VLNNGIMMPSIGLGTYRIRQSDIVMQVVDYALEAGYR 49
+LNNG MP +GLGT++ V + V A++ GYR
Sbjct: 6 LLNNGAKMPILGLGTWKSPPGQ-VTEAVKVAIDVGYR 41
>AF524864-1|AAO13380.1| 316|Homo sapiens aldo-ketoreductase
protein.
Length = 316
Score = 122 bits (294), Expect = 1e-27
Identities = 79/197 (40%), Positives = 114/197 (57%), Gaps = 18/197 (9%)
Query: 62 QAYQKSLENLDLEYVDLYLIHFPGGAK-----LPAEDKRNT---KMREL-SWCKLTELYD 112
+A++K+L++ L Y+D+YLIH+P G K P +DK N K L +W + EL D
Sbjct: 91 KAFEKTLKDPKLSYLDVYLIHWPQGFKSGDDLFPKDDKGNAIGGKATFLDAWEAMEELVD 150
Query: 113 DGKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSLYKFCKQHHITLQA 170
+G V A+GVSNF+ +E L+ + GL P NQVE HPY TQ L ++C IT+ A
Sbjct: 151 EGLVKALGVSNFSHFQIEKLL-NKPGLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTA 209
Query: 171 YCSFGG-----TSCSNNSLLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKAVHPEH 225
Y G + SLL DP + A K + T AQVL+ + +Q++V VIPK+V P
Sbjct: 210 YSPLGSPDRPWAKPEDPSLLEDPKIKEIAAKHKKTAAQVLIRFHIQRNVIVIPKSVTPAR 269
Query: 226 IKEN-RSLNFKIPEEDM 241
I EN + +FK+ +E+M
Sbjct: 270 IVENIQVFDFKLSDEEM 286
>BC005387-1|AAH05387.1| 316|Homo sapiens aldo-keto reductase family
1, member B1 (aldose reductase) protein.
Length = 316
Score = 120 bits (289), Expect = 5e-27
Identities = 75/199 (37%), Positives = 112/199 (56%), Gaps = 18/199 (9%)
Query: 63 AYQKSLENLDLEYVDLYLIHFPGGAK-----LPAEDKRNTKMRELSW----CKLTELYDD 113
A QK+L +L L+Y+DLYLIH+P G K P ++ N + + + EL D+
Sbjct: 92 ACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTRAAMEELVDE 151
Query: 114 GKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSLYKFCKQHHITLQAY 171
G V A+G+SNF +E ++ + GL PAVNQ+E HPY TQ L ++C+ I + AY
Sbjct: 152 GLVKAIGISNFNHLQVEMIL-NKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAY 210
Query: 172 CSFGG-----TSCSNNSLLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKAVHPEHI 226
G + SLL DP + + A K T AQVL+ + +Q+++ VIPK+V PE I
Sbjct: 211 SPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERI 270
Query: 227 KEN-RSLNFKIPEEDMKAL 244
EN + +F++ +DM L
Sbjct: 271 AENFKVFDFELSSQDMTTL 289
Score = 34.3 bits (75), Expect = 0.44
Identities = 16/37 (43%), Positives = 23/37 (62%), Gaps = 1/37 (2%)
Query: 13 VLNNGIMMPSIGLGTYRIRQSDIVMQVVDYALEAGYR 49
+LNNG MP +GLGT++ V + V A++ GYR
Sbjct: 6 LLNNGAKMPILGLGTWKSPPGQ-VTEAVKVAIDVGYR 41
>U05861-1|AAA18115.1| 323|Homo sapiens hepatic dihydrodiol
dehydrogenase protein.
Length = 323
Score = 117 bits (281), Expect = 5e-26
Identities = 77/224 (34%), Positives = 118/224 (52%), Gaps = 20/224 (8%)
Query: 49 RMFAPSDHGSRAEQAYQKSLENLDLEYVDLYLIHFPGGAK-----LPAEDKRNTKMRELS 103
+++ S A ++SL+NL L+YVDLYLIHFP K +P ++ +
Sbjct: 84 KLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVD 143
Query: 104 WCKLTELY----DDGKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSL 157
C E D G ++GVSNF LE ++ + GL P NQVE HPY+ Q L
Sbjct: 144 LCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMIL-NKPGLKYKPVCNQVECHPYFNQRKL 202
Query: 158 YKFCKQHHITLQAYCSFGG------TSCSNNSLLNDPVVVSTALKLEVTPAQVLLVWALQ 211
FCK I L AY + G ++ LL DPV+ + A K + TPA + L + LQ
Sbjct: 203 LDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQ 262
Query: 212 QDVAVIPKAVHPEHIKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
+ V V+ K+ + + I++N + F++ E+MKA++ L+ +NV+Y
Sbjct: 263 RGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN-RNVRY 305
>U05684-1|AAA16227.1| 323|Homo sapiens dihydrodiol dehydrogenase
protein.
Length = 323
Score = 117 bits (281), Expect = 5e-26
Identities = 77/224 (34%), Positives = 118/224 (52%), Gaps = 20/224 (8%)
Query: 49 RMFAPSDHGSRAEQAYQKSLENLDLEYVDLYLIHFPGGAK-----LPAEDKRNTKMRELS 103
+++ S A ++SL+NL L+YVDLYLIHFP K +P ++ +
Sbjct: 84 KLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVD 143
Query: 104 WCKLTELY----DDGKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSL 157
C E D G ++GVSNF LE ++ + GL P NQVE HPY+ Q L
Sbjct: 144 LCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMIL-NKPGLKYKPVCNQVECHPYFNQRKL 202
Query: 158 YKFCKQHHITLQAYCSFGG------TSCSNNSLLNDPVVVSTALKLEVTPAQVLLVWALQ 211
FCK I L AY + G ++ LL DPV+ + A K + TPA + L + LQ
Sbjct: 203 LDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQ 262
Query: 212 QDVAVIPKAVHPEHIKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
+ V V+ K+ + + I++N + F++ E+MKA++ L+ +NV+Y
Sbjct: 263 RGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN-RNVRY 305
>S68330-1|AAD14013.1| 323|Homo sapiens chlordecone reductase
homolog protein.
Length = 323
Score = 117 bits (281), Expect = 5e-26
Identities = 79/224 (35%), Positives = 122/224 (54%), Gaps = 20/224 (8%)
Query: 49 RMFAPSDHGSRAEQAYQKSLENLDLEYVDLYLIHFPGGAKLPAED----KRNTKMR---- 100
++++ S A ++SL+NL L+YVDLYLIHFP K P E+ N K+
Sbjct: 84 KLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVK-PGEEVIPKDENGKILFDTV 142
Query: 101 EL--SWCKLTELYDDGKVNAVGVSNFTVAHLEGLM-ESNHGLVPAVNQVEWHPYYTQSSL 157
+L +W + + D G ++GVSNF LE ++ E P NQVE HPY+ Q L
Sbjct: 143 DLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNEPGLKYEPVCNQVECHPYFNQRKL 202
Query: 158 YKFCKQHHITLQAYCSFGG------TSCSNNSLLNDPVVVSTALKLEVTPAQVLLVWALQ 211
FCK I L AY + G ++ LL DPV+ + A K + TPA + L + LQ
Sbjct: 203 LDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQ 262
Query: 212 QDVAVIPKAVHPEHIKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
+ V V+ K+ + + I++N + F++ E+MKA++ L+ +NV+Y
Sbjct: 263 RGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN-RNVRY 305
>M86609-1|AAB02880.1| 323|Homo sapiens dihydrodiol dehydrogenase
protein.
Length = 323
Score = 117 bits (281), Expect = 5e-26
Identities = 77/224 (34%), Positives = 118/224 (52%), Gaps = 20/224 (8%)
Query: 49 RMFAPSDHGSRAEQAYQKSLENLDLEYVDLYLIHFPGGAK-----LPAEDKRNTKMRELS 103
+++ S A ++SL+NL L+YVDLYLIHFP K +P ++ +
Sbjct: 84 KLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVD 143
Query: 104 WCKLTELY----DDGKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSL 157
C E D G ++GVSNF LE ++ + GL P NQVE HPY+ Q L
Sbjct: 144 LCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMIL-NKPGLKYKPVCNQVECHPYFNQRKL 202
Query: 158 YKFCKQHHITLQAYCSFGG------TSCSNNSLLNDPVVVSTALKLEVTPAQVLLVWALQ 211
FCK I L AY + G ++ LL DPV+ + A K + TPA + L + LQ
Sbjct: 203 LDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQ 262
Query: 212 QDVAVIPKAVHPEHIKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
+ V V+ K+ + + I++N + F++ E+MKA++ L+ +NV+Y
Sbjct: 263 RGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN-RNVRY 305
>D26124-1|BAA05121.1| 306|Homo sapiens dihydrodiol dehydrogenase
isoform DD1 protein.
Length = 306
Score = 117 bits (281), Expect = 5e-26
Identities = 77/224 (34%), Positives = 118/224 (52%), Gaps = 20/224 (8%)
Query: 49 RMFAPSDHGSRAEQAYQKSLENLDLEYVDLYLIHFPGGAK-----LPAEDKRNTKMRELS 103
+++ S A ++SL+NL L+YVDLYLIHFP K +P ++ +
Sbjct: 67 KLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVD 126
Query: 104 WCKLTELY----DDGKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSL 157
C E D G ++GVSNF LE ++ + GL P NQVE HPY+ Q L
Sbjct: 127 LCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMIL-NKPGLKYKPVCNQVECHPYFNQRKL 185
Query: 158 YKFCKQHHITLQAYCSFGG------TSCSNNSLLNDPVVVSTALKLEVTPAQVLLVWALQ 211
FCK I L AY + G ++ LL DPV+ + A K + TPA + L + LQ
Sbjct: 186 LDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQ 245
Query: 212 QDVAVIPKAVHPEHIKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
+ V V+ K+ + + I++N + F++ E+MKA++ L+ +NV+Y
Sbjct: 246 RGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN-RNVRY 288
>BT007197-1|AAP35861.1| 323|Homo sapiens aldo-keto reductase family
1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha
protein.
Length = 323
Score = 117 bits (281), Expect = 5e-26
Identities = 77/224 (34%), Positives = 118/224 (52%), Gaps = 20/224 (8%)
Query: 49 RMFAPSDHGSRAEQAYQKSLENLDLEYVDLYLIHFPGGAK-----LPAEDKRNTKMRELS 103
+++ S A ++SL+NL L+YVDLYLIHFP K +P ++ +
Sbjct: 84 KLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVD 143
Query: 104 WCKLTELY----DDGKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSL 157
C E D G ++GVSNF LE ++ + GL P NQVE HPY+ Q L
Sbjct: 144 LCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMIL-NKPGLKYKPVCNQVECHPYFNQRKL 202
Query: 158 YKFCKQHHITLQAYCSFGG------TSCSNNSLLNDPVVVSTALKLEVTPAQVLLVWALQ 211
FCK I L AY + G ++ LL DPV+ + A K + TPA + L + LQ
Sbjct: 203 LDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQ 262
Query: 212 QDVAVIPKAVHPEHIKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
+ V V+ K+ + + I++N + F++ E+MKA++ L+ +NV+Y
Sbjct: 263 RGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN-RNVRY 305
>BC040210-1|AAH40210.1| 323|Homo sapiens aldo-keto reductase family
1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha
protein.
Length = 323
Score = 117 bits (281), Expect = 5e-26
Identities = 77/224 (34%), Positives = 118/224 (52%), Gaps = 20/224 (8%)
Query: 49 RMFAPSDHGSRAEQAYQKSLENLDLEYVDLYLIHFPGGAK-----LPAEDKRNTKMRELS 103
+++ S A ++SL+NL L+YVDLYLIHFP K +P ++ +
Sbjct: 84 KLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVD 143
Query: 104 WCKLTELY----DDGKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSL 157
C E D G ++GVSNF LE ++ + GL P NQVE HPY+ Q L
Sbjct: 144 LCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMIL-NKPGLKYKPVCNQVECHPYFNQRKL 202
Query: 158 YKFCKQHHITLQAYCSFGG------TSCSNNSLLNDPVVVSTALKLEVTPAQVLLVWALQ 211
FCK I L AY + G ++ LL DPV+ + A K + TPA + L + LQ
Sbjct: 203 LDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQ 262
Query: 212 QDVAVIPKAVHPEHIKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
+ V V+ K+ + + I++N + F++ E+MKA++ L+ +NV+Y
Sbjct: 263 RGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN-RNVRY 305
>BC020216-1|AAH20216.1| 323|Homo sapiens aldo-keto reductase family
1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha
protein.
Length = 323
Score = 117 bits (281), Expect = 5e-26
Identities = 77/224 (34%), Positives = 118/224 (52%), Gaps = 20/224 (8%)
Query: 49 RMFAPSDHGSRAEQAYQKSLENLDLEYVDLYLIHFPGGAK-----LPAEDKRNTKMRELS 103
+++ S A ++SL+NL L+YVDLYLIHFP K +P ++ +
Sbjct: 84 KLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVD 143
Query: 104 WCKLTELY----DDGKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSL 157
C E D G ++GVSNF LE ++ + GL P NQVE HPY+ Q L
Sbjct: 144 LCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMIL-NKPGLKYKPVCNQVECHPYFNQRKL 202
Query: 158 YKFCKQHHITLQAYCSFGG------TSCSNNSLLNDPVVVSTALKLEVTPAQVLLVWALQ 211
FCK I L AY + G ++ LL DPV+ + A K + TPA + L + LQ
Sbjct: 203 LDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQ 262
Query: 212 QDVAVIPKAVHPEHIKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
+ V V+ K+ + + I++N + F++ E+MKA++ L+ +NV+Y
Sbjct: 263 RGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN-RNVRY 305
>BC015490-1|AAH15490.1| 323|Homo sapiens aldo-keto reductase family
1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha
protein.
Length = 323
Score = 117 bits (281), Expect = 5e-26
Identities = 77/224 (34%), Positives = 118/224 (52%), Gaps = 20/224 (8%)
Query: 49 RMFAPSDHGSRAEQAYQKSLENLDLEYVDLYLIHFPGGAK-----LPAEDKRNTKMRELS 103
+++ S A ++SL+NL L+YVDLYLIHFP K +P ++ +
Sbjct: 84 KLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVD 143
Query: 104 WCKLTELY----DDGKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSL 157
C E D G ++GVSNF LE ++ + GL P NQVE HPY+ Q L
Sbjct: 144 LCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMIL-NKPGLKYKPVCNQVECHPYFNQRKL 202
Query: 158 YKFCKQHHITLQAYCSFGG------TSCSNNSLLNDPVVVSTALKLEVTPAQVLLVWALQ 211
FCK I L AY + G ++ LL DPV+ + A K + TPA + L + LQ
Sbjct: 203 LDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQ 262
Query: 212 QDVAVIPKAVHPEHIKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
+ V V+ K+ + + I++N + F++ E+MKA++ L+ +NV+Y
Sbjct: 263 RGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN-RNVRY 305
>AL713867-2|CAI16409.1| 323|Homo sapiens aldo-keto reductase family
1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha
protein.
Length = 323
Score = 117 bits (281), Expect = 5e-26
Identities = 77/224 (34%), Positives = 118/224 (52%), Gaps = 20/224 (8%)
Query: 49 RMFAPSDHGSRAEQAYQKSLENLDLEYVDLYLIHFPGGAK-----LPAEDKRNTKMRELS 103
+++ S A ++SL+NL L+YVDLYLIHFP K +P ++ +
Sbjct: 84 KLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVD 143
Query: 104 WCKLTELY----DDGKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSL 157
C E D G ++GVSNF LE ++ + GL P NQVE HPY+ Q L
Sbjct: 144 LCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMIL-NKPGLKYKPVCNQVECHPYFNQRKL 202
Query: 158 YKFCKQHHITLQAYCSFGG------TSCSNNSLLNDPVVVSTALKLEVTPAQVLLVWALQ 211
FCK I L AY + G ++ LL DPV+ + A K + TPA + L + LQ
Sbjct: 203 LDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQ 262
Query: 212 QDVAVIPKAVHPEHIKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
+ V V+ K+ + + I++N + F++ E+MKA++ L+ +NV+Y
Sbjct: 263 RGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN-RNVRY 305
>AB032150-1|BAA92886.1| 323|Homo sapiens 20 alph-hydroxysteroid
dehydrogenase protein.
Length = 323
Score = 117 bits (281), Expect = 5e-26
Identities = 77/224 (34%), Positives = 118/224 (52%), Gaps = 20/224 (8%)
Query: 49 RMFAPSDHGSRAEQAYQKSLENLDLEYVDLYLIHFPGGAK-----LPAEDKRNTKMRELS 103
+++ S A ++SL+NL L+YVDLYLIHFP K +P ++ +
Sbjct: 84 KLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVD 143
Query: 104 WCKLTELY----DDGKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSL 157
C E D G ++GVSNF LE ++ + GL P NQVE HPY+ Q L
Sbjct: 144 LCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMIL-NKPGLKYKPVCNQVECHPYFNQRKL 202
Query: 158 YKFCKQHHITLQAYCSFGG------TSCSNNSLLNDPVVVSTALKLEVTPAQVLLVWALQ 211
FCK I L AY + G ++ LL DPV+ + A K + TPA + L + LQ
Sbjct: 203 LDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQ 262
Query: 212 QDVAVIPKAVHPEHIKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
+ V V+ K+ + + I++N + F++ E+MKA++ L+ +NV+Y
Sbjct: 263 RGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN-RNVRY 305
>AB031083-1|BAA92883.1| 323|Homo sapiens 20 alpha-hydroxysteroid
dehydrogenase protein.
Length = 323
Score = 117 bits (281), Expect = 5e-26
Identities = 77/224 (34%), Positives = 118/224 (52%), Gaps = 20/224 (8%)
Query: 49 RMFAPSDHGSRAEQAYQKSLENLDLEYVDLYLIHFPGGAK-----LPAEDKRNTKMRELS 103
+++ S A ++SL+NL L+YVDLYLIHFP K +P ++ +
Sbjct: 84 KLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVD 143
Query: 104 WCKLTELY----DDGKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSL 157
C E D G ++GVSNF LE ++ + GL P NQVE HPY+ Q L
Sbjct: 144 LCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMIL-NKPGLKYKPVCNQVECHPYFNQRKL 202
Query: 158 YKFCKQHHITLQAYCSFGG------TSCSNNSLLNDPVVVSTALKLEVTPAQVLLVWALQ 211
FCK I L AY + G ++ LL DPV+ + A K + TPA + L + LQ
Sbjct: 203 LDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQ 262
Query: 212 QDVAVIPKAVHPEHIKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
+ V V+ K+ + + I++N + F++ E+MKA++ L+ +NV+Y
Sbjct: 263 RGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN-RNVRY 305
>U05598-1|AAA20937.1| 323|Homo sapiens dihydrodiol dehydrogenase
protein.
Length = 323
Score = 116 bits (279), Expect = 8e-26
Identities = 80/225 (35%), Positives = 124/225 (55%), Gaps = 22/225 (9%)
Query: 49 RMFAPSDHGSRAEQAYQKSLENLDLEYVDLYLIHFPGGAKLPAED----KRNTKMR---- 100
++++ S A ++SL+NL L+YVDLYLIHFP K P E+ N K+
Sbjct: 84 KLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVK-PGEEVIPKDENGKILFDTV 142
Query: 101 EL--SWCKLTELYDDGKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSS 156
+L +W + + D G ++GVSNF LE ++ + GL P NQVE HPY+ Q
Sbjct: 143 DLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMIL-NKPGLKYKPVCNQVECHPYFNQRK 201
Query: 157 LYKFCKQHHITLQAYCSFGG------TSCSNNSLLNDPVVVSTALKLEVTPAQVLLVWAL 210
L FCK I L AY + G ++ LL DPV+ + A K + TPA + L + L
Sbjct: 202 LLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQL 261
Query: 211 QQDVAVIPKAVHPEHIKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
Q+ V V+ K+ + + I++N + F++ E+MKA++ L+ +NV+Y
Sbjct: 262 QRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN-RNVRY 305
>BT006653-1|AAP35299.1| 323|Homo sapiens aldo-keto reductase family
1, member C2 (dihydrodiol dehydrogenase 2; bile acid
protein.
Length = 323
Score = 116 bits (279), Expect = 8e-26
Identities = 80/225 (35%), Positives = 124/225 (55%), Gaps = 22/225 (9%)
Query: 49 RMFAPSDHGSRAEQAYQKSLENLDLEYVDLYLIHFPGGAKLPAED----KRNTKMR---- 100
++++ S A ++SL+NL L+YVDLYLIHFP K P E+ N K+
Sbjct: 84 KLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVK-PGEEVIPKDENGKILFDTV 142
Query: 101 EL--SWCKLTELYDDGKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSS 156
+L +W + + D G ++GVSNF LE ++ + GL P NQVE HPY+ Q
Sbjct: 143 DLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMIL-NKPGLKYKPVCNQVECHPYFNQRK 201
Query: 157 LYKFCKQHHITLQAYCSFGG------TSCSNNSLLNDPVVVSTALKLEVTPAQVLLVWAL 210
L FCK I L AY + G ++ LL DPV+ + A K + TPA + L + L
Sbjct: 202 LLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQL 261
Query: 211 QQDVAVIPKAVHPEHIKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
Q+ V V+ K+ + + I++N + F++ E+MKA++ L+ +NV+Y
Sbjct: 262 QRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN-RNVRY 305
>BC063574-1|AAH63574.1| 323|Homo sapiens aldo-keto reductase family
1, member C2 (dihydrodiol dehydrogenase 2; bile acid
protein.
Length = 323
Score = 116 bits (279), Expect = 8e-26
Identities = 80/225 (35%), Positives = 124/225 (55%), Gaps = 22/225 (9%)
Query: 49 RMFAPSDHGSRAEQAYQKSLENLDLEYVDLYLIHFPGGAKLPAED----KRNTKMR---- 100
++++ S A ++SL+NL L+YVDLYLIHFP K P E+ N K+
Sbjct: 84 KLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVK-PGEEVIPKDENGKILFDTV 142
Query: 101 EL--SWCKLTELYDDGKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSS 156
+L +W + + D G ++GVSNF LE ++ + GL P NQVE HPY+ Q
Sbjct: 143 DLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMIL-NKPGLKYKPVCNQVECHPYFNQRK 201
Query: 157 LYKFCKQHHITLQAYCSFGG------TSCSNNSLLNDPVVVSTALKLEVTPAQVLLVWAL 210
L FCK I L AY + G ++ LL DPV+ + A K + TPA + L + L
Sbjct: 202 LLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQL 261
Query: 211 QQDVAVIPKAVHPEHIKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
Q+ V V+ K+ + + I++N + F++ E+MKA++ L+ +NV+Y
Sbjct: 262 QRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN-RNVRY 305
>BC007024-1|AAH07024.1| 323|Homo sapiens aldo-keto reductase family
1, member C2 (dihydrodiol dehydrogenase 2; bile acid
protein.
Length = 323
Score = 116 bits (279), Expect = 8e-26
Identities = 80/225 (35%), Positives = 124/225 (55%), Gaps = 22/225 (9%)
Query: 49 RMFAPSDHGSRAEQAYQKSLENLDLEYVDLYLIHFPGGAKLPAED----KRNTKMR---- 100
++++ S A ++SL+NL L+YVDLYLIHFP K P E+ N K+
Sbjct: 84 KLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVK-PGEEVIPKDENGKILFDTV 142
Query: 101 EL--SWCKLTELYDDGKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSS 156
+L +W + + D G ++GVSNF LE ++ + GL P NQVE HPY+ Q
Sbjct: 143 DLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMIL-NKPGLKYKPVCNQVECHPYFNQRK 201
Query: 157 LYKFCKQHHITLQAYCSFGG------TSCSNNSLLNDPVVVSTALKLEVTPAQVLLVWAL 210
L FCK I L AY + G ++ LL DPV+ + A K + TPA + L + L
Sbjct: 202 LLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQL 261
Query: 211 QQDVAVIPKAVHPEHIKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
Q+ V V+ K+ + + I++N + F++ E+MKA++ L+ +NV+Y
Sbjct: 262 QRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN-RNVRY 305
>AL713867-1|CAI16408.1| 323|Homo sapiens aldo-keto reductase family
1, member C2 (dihydrodiol dehydrogenase 2; bile acid
protein.
Length = 323
Score = 116 bits (279), Expect = 8e-26
Identities = 80/225 (35%), Positives = 124/225 (55%), Gaps = 22/225 (9%)
Query: 49 RMFAPSDHGSRAEQAYQKSLENLDLEYVDLYLIHFPGGAKLPAED----KRNTKMR---- 100
++++ S A ++SL+NL L+YVDLYLIHFP K P E+ N K+
Sbjct: 84 KLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVK-PGEEVIPKDENGKILFDTV 142
Query: 101 EL--SWCKLTELYDDGKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSS 156
+L +W + + D G ++GVSNF LE ++ + GL P NQVE HPY+ Q
Sbjct: 143 DLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMIL-NKPGLKYKPVCNQVECHPYFNQRK 201
Query: 157 LYKFCKQHHITLQAYCSFGG------TSCSNNSLLNDPVVVSTALKLEVTPAQVLLVWAL 210
L FCK I L AY + G ++ LL DPV+ + A K + TPA + L + L
Sbjct: 202 LLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQL 261
Query: 211 QQDVAVIPKAVHPEHIKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
Q+ V V+ K+ + + I++N + F++ E+MKA++ L+ +NV+Y
Sbjct: 262 QRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN-RNVRY 305
>AL391427-1|CAI14726.1| 323|Homo sapiens aldo-keto reductase family
1, member C2 (dihydrodiol dehydrogenase 2; bile acid
protein.
Length = 323
Score = 116 bits (279), Expect = 8e-26
Identities = 80/225 (35%), Positives = 124/225 (55%), Gaps = 22/225 (9%)
Query: 49 RMFAPSDHGSRAEQAYQKSLENLDLEYVDLYLIHFPGGAKLPAED----KRNTKMR---- 100
++++ S A ++SL+NL L+YVDLYLIHFP K P E+ N K+
Sbjct: 84 KLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVK-PGEEVIPKDENGKILFDTV 142
Query: 101 EL--SWCKLTELYDDGKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSS 156
+L +W + + D G ++GVSNF LE ++ + GL P NQVE HPY+ Q
Sbjct: 143 DLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMIL-NKPGLKYKPVCNQVECHPYFNQRK 201
Query: 157 LYKFCKQHHITLQAYCSFGG------TSCSNNSLLNDPVVVSTALKLEVTPAQVLLVWAL 210
L FCK I L AY + G ++ LL DPV+ + A K + TPA + L + L
Sbjct: 202 LLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQL 261
Query: 211 QQDVAVIPKAVHPEHIKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
Q+ V V+ K+ + + I++N + F++ E+MKA++ L+ +NV+Y
Sbjct: 262 QRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN-RNVRY 305
>AB032153-1|BAA92891.1| 323|Homo sapiens bile acid-binding protein
protein.
Length = 323
Score = 116 bits (279), Expect = 8e-26
Identities = 80/225 (35%), Positives = 124/225 (55%), Gaps = 22/225 (9%)
Query: 49 RMFAPSDHGSRAEQAYQKSLENLDLEYVDLYLIHFPGGAKLPAED----KRNTKMR---- 100
++++ S A ++SL+NL L+YVDLYLIHFP K P E+ N K+
Sbjct: 84 KLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVK-PGEEVIPKDENGKILFDTV 142
Query: 101 EL--SWCKLTELYDDGKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSS 156
+L +W + + D G ++GVSNF LE ++ + GL P NQVE HPY+ Q
Sbjct: 143 DLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMIL-NKPGLKYKPVCNQVECHPYFNQRK 201
Query: 157 LYKFCKQHHITLQAYCSFGG------TSCSNNSLLNDPVVVSTALKLEVTPAQVLLVWAL 210
L FCK I L AY + G ++ LL DPV+ + A K + TPA + L + L
Sbjct: 202 LLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQL 261
Query: 211 QQDVAVIPKAVHPEHIKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
Q+ V V+ K+ + + I++N + F++ E+MKA++ L+ +NV+Y
Sbjct: 262 QRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN-RNVRY 305
>AB031084-1|BAA92884.1| 323|Homo sapiens bile acid-binding protein
protein.
Length = 323
Score = 116 bits (279), Expect = 8e-26
Identities = 80/225 (35%), Positives = 124/225 (55%), Gaps = 22/225 (9%)
Query: 49 RMFAPSDHGSRAEQAYQKSLENLDLEYVDLYLIHFPGGAKLPAED----KRNTKMR---- 100
++++ S A ++SL+NL L+YVDLYLIHFP K P E+ N K+
Sbjct: 84 KLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVK-PGEEVIPKDENGKILFDTV 142
Query: 101 EL--SWCKLTELYDDGKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSS 156
+L +W + + D G ++GVSNF LE ++ + GL P NQVE HPY+ Q
Sbjct: 143 DLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMIL-NKPGLKYKPVCNQVECHPYFNQRK 201
Query: 157 LYKFCKQHHITLQAYCSFGG------TSCSNNSLLNDPVVVSTALKLEVTPAQVLLVWAL 210
L FCK I L AY + G ++ LL DPV+ + A K + TPA + L + L
Sbjct: 202 LLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQL 261
Query: 211 QQDVAVIPKAVHPEHIKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
Q+ V V+ K+ + + I++N + F++ E+MKA++ L+ +NV+Y
Sbjct: 262 QRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN-RNVRY 305
>AB021654-1|BAA36169.1| 323|Homo sapiens DD2/bile acid-binding
protein/AKR1C2/3alpha-hydroxysteroid dehydrogenase type
3 protein.
Length = 323
Score = 116 bits (279), Expect = 8e-26
Identities = 80/225 (35%), Positives = 124/225 (55%), Gaps = 22/225 (9%)
Query: 49 RMFAPSDHGSRAEQAYQKSLENLDLEYVDLYLIHFPGGAKLPAED----KRNTKMR---- 100
++++ S A ++SL+NL L+YVDLYLIHFP K P E+ N K+
Sbjct: 84 KLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVK-PGEEVIPKDENGKILFDTV 142
Query: 101 EL--SWCKLTELYDDGKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSS 156
+L +W + + D G ++GVSNF LE ++ + GL P NQVE HPY+ Q
Sbjct: 143 DLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMIL-NKPGLKYKPVCNQVECHPYFNQRK 201
Query: 157 LYKFCKQHHITLQAYCSFGG------TSCSNNSLLNDPVVVSTALKLEVTPAQVLLVWAL 210
L FCK I L AY + G ++ LL DPV+ + A K + TPA + L + L
Sbjct: 202 LLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQL 261
Query: 211 QQDVAVIPKAVHPEHIKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
Q+ V V+ K+ + + I++N + F++ E+MKA++ L+ +NV+Y
Sbjct: 262 QRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN-RNVRY 305
>L32592-1|AAB38486.1| 323|Homo sapiens dihydrodiol
dehydrogenase/bile acid-binding protein protein.
Length = 323
Score = 115 bits (277), Expect = 1e-25
Identities = 78/224 (34%), Positives = 121/224 (54%), Gaps = 20/224 (8%)
Query: 49 RMFAPSDHGSRAEQAYQKSLENLDLEYVDLYLIHFPGGAKLPAED----KRNTKMR---- 100
++++ S A ++SL+NL L+Y DLYLIHFP K P E+ N K+
Sbjct: 84 KLWSNSHRPELVRPALERSLKNLQLDYADLYLIHFPVSVK-PGEEVIPKDENGKILFDTV 142
Query: 101 EL--SWCKLTELYDDGKVNAVGVSNFTVAHLEGLM-ESNHGLVPAVNQVEWHPYYTQSSL 157
+L +W + + D G ++GVSNF LE ++ E P NQVE HPY+ Q L
Sbjct: 143 DLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNEPGLKYEPVCNQVECHPYFNQRKL 202
Query: 158 YKFCKQHHITLQAYCSFGG------TSCSNNSLLNDPVVVSTALKLEVTPAQVLLVWALQ 211
FCK I L AY + G ++ LL DPV+ + A K + TPA + L + LQ
Sbjct: 203 LDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQ 262
Query: 212 QDVAVIPKAVHPEHIKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
+ V V+ K+ + + I++N + F++ E+MKA++ L+ +NV+Y
Sbjct: 263 RGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN-RNVRY 305
Score = 30.3 bits (65), Expect = 7.1
Identities = 15/37 (40%), Positives = 21/37 (56%), Gaps = 2/37 (5%)
Query: 14 LNNGIMMPSIGLGTYRIRQ--SDIVMQVVDYALEAGY 48
LN+G MP +G GTY + ++ V A+EAGY
Sbjct: 10 LNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGY 46
>S68290-1|AAD14012.1| 320|Homo sapiens chlordecone reductase
homolog protein.
Length = 320
Score = 115 bits (276), Expect = 2e-25
Identities = 76/209 (36%), Positives = 113/209 (54%), Gaps = 18/209 (8%)
Query: 63 AYQKSLENLDLEYVDLYLIHFPGGAK-----LPAEDKRNTKMRELSWCKLTELYDDGK-- 115
A ++SL+NL L+YVDLYLIHFP K +P ++ + C E + K
Sbjct: 95 ALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAVEKCKDA 154
Query: 116 --VNAVGVSNFTVAHLEGLMESNHGLV-PAVNQVEWHPYYTQSSLYKFCKQHHITLQAYC 172
++GVSNF + LE ++ V P NQVE HPY+ Q L FCK I L AY
Sbjct: 155 ELAKSIGVSNFNRSTLEMILNKPGLQVKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYS 214
Query: 173 SFGGTS----CSNNS--LLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKAVHPEHI 226
+ G NS LL DPV+ + A K + TPA + L + LQ+ V V+ K+ + + I
Sbjct: 215 ALGSLREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRI 274
Query: 227 KEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
++N + F++ E+MKA++ L+ +NV+Y
Sbjct: 275 RQNVQVFEFQLTSEEMKAIDGLN-RNVRY 302
>AL355303-2|CAI14202.1| 323|Homo sapiens aldo-keto reductase family
1, member C4 (chlordecone reductase; 3-alpha hydroxy
protein.
Length = 323
Score = 114 bits (274), Expect = 3e-25
Identities = 78/212 (36%), Positives = 114/212 (53%), Gaps = 20/212 (9%)
Query: 61 EQAYQKSLENLDLEYVDLYLIHFP-----GGAKLPAEDKR----NTKMRELSWCKLTELY 111
+ A + SL+ L L+YVDLYL+HFP G LP ++ +T +W + +
Sbjct: 96 QPALESSLKKLQLDYVDLYLLHFPMALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCK 155
Query: 112 DDGKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSLYKFCKQHHITLQ 169
D G ++GVSNF LE ++ + GL P NQVE HPY QS L FCK I L
Sbjct: 156 DAGLAKSIGVSNFNCRQLEMIL-NKPGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLV 214
Query: 170 AYCSFGGTS----CSNNS--LLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKAVHP 223
A+ + G NS LL DPV+ + A K + TPA + L + LQ+ V V+ K+ +
Sbjct: 215 AHSALGTQRHKLWVDPNSPVLLEDPVLCALAKKHKQTPALIALRYQLQRGVVVLAKSYNE 274
Query: 224 EHIKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
+ I+EN + F++ EDMK L+ L+ +N +Y
Sbjct: 275 QRIRENIQVFEFQLTSEDMKVLDGLN-RNYRY 305
Score = 29.9 bits (64), Expect = 9.4
Identities = 15/38 (39%), Positives = 23/38 (60%), Gaps = 2/38 (5%)
Query: 14 LNNGIMMPSIGLGTYRIRQ--SDIVMQVVDYALEAGYR 49
LN+G MP +G GTY + + ++V A+EAG+R
Sbjct: 10 LNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFR 47
>S68287-1|AAD14010.1| 323|Homo sapiens chlordecone reductase
protein.
Length = 323
Score = 113 bits (273), Expect = 4e-25
Identities = 78/212 (36%), Positives = 114/212 (53%), Gaps = 20/212 (9%)
Query: 61 EQAYQKSLENLDLEYVDLYLIHFP-----GGAKLPAEDKR----NTKMRELSWCKLTELY 111
+ A + SL+ L L+YVDLYL+HFP G LP ++ +T +W + +
Sbjct: 96 QPALESSLKKLQLDYVDLYLLHFPMALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCK 155
Query: 112 DDGKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSLYKFCKQHHITLQ 169
D G ++GVSNF LE ++ + GL P NQVE HPY QS L FCK I L
Sbjct: 156 DAGLAKSIGVSNFNCRQLEMIL-NKPGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLV 214
Query: 170 AYCSFGGTS----CSNNS--LLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKAVHP 223
A+ + G NS LL DPV+ + A K + TPA + L + LQ+ V V+ K+ +
Sbjct: 215 AHSALGTQRHKLWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNE 274
Query: 224 EHIKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
+ I+EN + F++ EDMK L+ L+ +N +Y
Sbjct: 275 QRIRENIQVFEFQLTSEDMKVLDGLN-RNYRY 305
Score = 29.9 bits (64), Expect = 9.4
Identities = 15/38 (39%), Positives = 23/38 (60%), Gaps = 2/38 (5%)
Query: 14 LNNGIMMPSIGLGTYRIRQ--SDIVMQVVDYALEAGYR 49
LN+G MP +G GTY + + ++V A+EAG+R
Sbjct: 10 LNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFR 47
>M33375-1|AAA35658.1| 308|Homo sapiens protein ( Human chlordecone
reductase mRNA, complete cds. ).
Length = 308
Score = 113 bits (273), Expect = 4e-25
Identities = 78/212 (36%), Positives = 114/212 (53%), Gaps = 20/212 (9%)
Query: 61 EQAYQKSLENLDLEYVDLYLIHFP-----GGAKLPAEDKR----NTKMRELSWCKLTELY 111
+ A + SL+ L L+YVDLYL+HFP G LP ++ +T +W + +
Sbjct: 81 QPALESSLKKLQLDYVDLYLLHFPMALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCK 140
Query: 112 DDGKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSLYKFCKQHHITLQ 169
D G ++GVSNF LE ++ + GL P NQVE HPY QS L FCK I L
Sbjct: 141 DAGLAKSIGVSNFNCRQLEMIL-NKPGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLV 199
Query: 170 AYCSFGGTS----CSNNS--LLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKAVHP 223
A+ + G NS LL DPV+ + A K + TPA + L + LQ+ V V+ K+ +
Sbjct: 200 AHSALGTQRHKLWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNE 259
Query: 224 EHIKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
+ I+EN + F++ EDMK L+ L+ +N +Y
Sbjct: 260 QRIRENIQVFEFQLTSEDMKVLDGLN-RNYRY 290
>D26125-1|BAA05122.1| 321|Homo sapiens 3
alpha-hydroxysteroid/dihydrodiol dehydrogenase DD4
protein.
Length = 321
Score = 113 bits (273), Expect = 4e-25
Identities = 78/212 (36%), Positives = 114/212 (53%), Gaps = 20/212 (9%)
Query: 61 EQAYQKSLENLDLEYVDLYLIHFP-----GGAKLPAEDKR----NTKMRELSWCKLTELY 111
+ A + SL+ L L+YVDLYL+HFP G LP ++ +T +W + +
Sbjct: 94 QPALESSLKKLQLDYVDLYLLHFPMALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCK 153
Query: 112 DDGKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSLYKFCKQHHITLQ 169
D G ++GVSNF LE ++ + GL P NQVE HPY QS L FCK I L
Sbjct: 154 DAGLAKSIGVSNFNCRQLEMIL-NKPGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLV 212
Query: 170 AYCSFGGTS----CSNNS--LLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKAVHP 223
A+ + G NS LL DPV+ + A K + TPA + L + LQ+ V V+ K+ +
Sbjct: 213 AHSALGTQRHKLWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNE 272
Query: 224 EHIKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
+ I+EN + F++ EDMK L+ L+ +N +Y
Sbjct: 273 QRIRENIQVFEFQLTSEDMKVLDGLN-RNYRY 303
Score = 29.9 bits (64), Expect = 9.4
Identities = 15/38 (39%), Positives = 23/38 (60%), Gaps = 2/38 (5%)
Query: 14 LNNGIMMPSIGLGTYRIRQ--SDIVMQVVDYALEAGYR 49
LN+G MP +G GTY + + ++V A+EAG+R
Sbjct: 8 LNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFR 45
>BC020744-1|AAH20744.1| 323|Homo sapiens aldo-keto reductase family
1, member C4 (chlordecone reductase; 3-alpha hydroxy
protein.
Length = 323
Score = 113 bits (273), Expect = 4e-25
Identities = 78/212 (36%), Positives = 114/212 (53%), Gaps = 20/212 (9%)
Query: 61 EQAYQKSLENLDLEYVDLYLIHFP-----GGAKLPAEDKR----NTKMRELSWCKLTELY 111
+ A + SL+ L L+YVDLYL+HFP G LP ++ +T +W + +
Sbjct: 96 QPALESSLKKLQLDYVDLYLLHFPMALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCK 155
Query: 112 DDGKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSLYKFCKQHHITLQ 169
D G ++GVSNF LE ++ + GL P NQVE HPY QS L FCK I L
Sbjct: 156 DAGLAKSIGVSNFNYRQLEMIL-NKPGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLV 214
Query: 170 AYCSFGGTS----CSNNS--LLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKAVHP 223
A+ + G NS LL DPV+ + A K + TPA + L + LQ+ V V+ K+ +
Sbjct: 215 AHSALGTQRHKLWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNE 274
Query: 224 EHIKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
+ I+EN + F++ EDMK L+ L+ +N +Y
Sbjct: 275 QRIRENIQVFEFQLTSEDMKVLDGLN-RNYRY 305
Score = 29.9 bits (64), Expect = 9.4
Identities = 15/38 (39%), Positives = 23/38 (60%), Gaps = 2/38 (5%)
Query: 14 LNNGIMMPSIGLGTYRIRQ--SDIVMQVVDYALEAGYR 49
LN+G MP +G GTY + + ++V A+EAG+R
Sbjct: 10 LNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFR 47
>AB045829-1|BAA99542.1| 323|Homo sapiens 3alpha-hydroxysteroid
dehydrogenase variant protein.
Length = 323
Score = 113 bits (273), Expect = 4e-25
Identities = 78/212 (36%), Positives = 112/212 (52%), Gaps = 20/212 (9%)
Query: 61 EQAYQKSLENLDLEYVDLYLIHFP-----GGAKLPAEDKRNTKMRELSWCKLTELY---- 111
+ A + SL+ L L+YVDLYL+HFP G LP ++ + C E+
Sbjct: 96 QPALESSLKKLQLDYVDLYLLHFPMALKPGETPLPKDENGKVIFDTVDLCATWEVMEKCK 155
Query: 112 DDGKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSLYKFCKQHHITLQ 169
D G ++GVSNF LE ++ + GL P NQVE HPY QS L FCK I L
Sbjct: 156 DAGLAKSIGVSNFNCRQLEMIL-NKPGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLV 214
Query: 170 AYCSFGGTS----CSNNS--LLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKAVHP 223
A+ + G NS LL DPV+ + A K + TPA + L + LQ+ V V+ K+ +
Sbjct: 215 AHSALGTQRHKLWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNE 274
Query: 224 EHIKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
+ I+EN + F++ EDMK L+ L+ +N +Y
Sbjct: 275 QRIRENIQVFEFQLTSEDMKVLDGLN-RNYRY 305
Score = 29.9 bits (64), Expect = 9.4
Identities = 15/38 (39%), Positives = 23/38 (60%), Gaps = 2/38 (5%)
Query: 14 LNNGIMMPSIGLGTYRIRQ--SDIVMQVVDYALEAGYR 49
LN+G MP +G GTY + + ++V A+EAG+R
Sbjct: 10 LNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFR 47
>AB032163-1|BAA92893.1| 323|Homo sapiens dihydrodiol dehydrogenase
4 protein.
Length = 323
Score = 113 bits (273), Expect = 4e-25
Identities = 78/212 (36%), Positives = 114/212 (53%), Gaps = 20/212 (9%)
Query: 61 EQAYQKSLENLDLEYVDLYLIHFP-----GGAKLPAEDKR----NTKMRELSWCKLTELY 111
+ A + SL+ L L+YVDLYL+HFP G LP ++ +T +W + +
Sbjct: 96 QPALESSLKKLQLDYVDLYLLHFPMALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCK 155
Query: 112 DDGKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSLYKFCKQHHITLQ 169
D G ++GVSNF LE ++ + GL P NQVE HPY QS L FCK I L
Sbjct: 156 DAGLAKSIGVSNFNCRQLEMIL-NKPGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLV 214
Query: 170 AYCSFGGTS----CSNNS--LLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKAVHP 223
A+ + G NS LL DPV+ + A K + TPA + L + LQ+ V V+ K+ +
Sbjct: 215 AHSALGTQRHKLWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNE 274
Query: 224 EHIKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
+ I+EN + F++ EDMK L+ L+ +N +Y
Sbjct: 275 QRIRENIQVFEFQLTSEDMKVLDGLN-RNYRY 305
Score = 29.9 bits (64), Expect = 9.4
Identities = 15/38 (39%), Positives = 23/38 (60%), Gaps = 2/38 (5%)
Query: 14 LNNGIMMPSIGLGTYRIRQ--SDIVMQVVDYALEAGYR 49
LN+G MP +G GTY + + ++V A+EAG+R
Sbjct: 10 LNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFR 47
>AB031085-1|BAA92885.1| 323|Homo sapiens dihydrodiol dehydrogenase
4 protein.
Length = 323
Score = 113 bits (273), Expect = 4e-25
Identities = 78/212 (36%), Positives = 114/212 (53%), Gaps = 20/212 (9%)
Query: 61 EQAYQKSLENLDLEYVDLYLIHFP-----GGAKLPAEDKR----NTKMRELSWCKLTELY 111
+ A + SL+ L L+YVDLYL+HFP G LP ++ +T +W + +
Sbjct: 96 QPALESSLKKLQLDYVDLYLLHFPMALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCK 155
Query: 112 DDGKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSLYKFCKQHHITLQ 169
D G ++GVSNF LE ++ + GL P NQVE HPY QS L FCK I L
Sbjct: 156 DAGLAKSIGVSNFNCRQLEMIL-NKPGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLV 214
Query: 170 AYCSFGGTS----CSNNS--LLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKAVHP 223
A+ + G NS LL DPV+ + A K + TPA + L + LQ+ V V+ K+ +
Sbjct: 215 AHSALGTQRHKLWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNE 274
Query: 224 EHIKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
+ I+EN + F++ EDMK L+ L+ +N +Y
Sbjct: 275 QRIRENIQVFEFQLTSEDMKVLDGLN-RNYRY 305
Score = 29.9 bits (64), Expect = 9.4
Identities = 15/38 (39%), Positives = 23/38 (60%), Gaps = 2/38 (5%)
Query: 14 LNNGIMMPSIGLGTYRIRQ--SDIVMQVVDYALEAGYR 49
LN+G MP +G GTY + + ++V A+EAG+R
Sbjct: 10 LNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFR 47
>AL713867-3|CAI16410.1| 247|Homo sapiens aldo-keto reductase family
1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha
protein.
Length = 247
Score = 111 bits (268), Expect = 2e-24
Identities = 78/240 (32%), Positives = 120/240 (50%), Gaps = 25/240 (10%)
Query: 14 LNNGIMMPSIGLGTYRIRQSDIVMQ--VVDYALEAG-----YRMFAPSDHGSRAEQAYQK 66
LN+G MP +G GTY + + ++ + D +++ +++ S A ++
Sbjct: 8 LNDGHFMPVLGFGTYAPAEVGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALER 67
Query: 67 SLENLDLEYVDLYLIHFPGGAK-----LPAEDKRNTKMRELSWCKLTELY----DDGKVN 117
SL+NL L+YVDLYLIHFP K +P ++ + C E D G
Sbjct: 68 SLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAK 127
Query: 118 AVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSLYKFCKQHHITLQAYCSFG 175
++GVSNF LE ++ + GL P NQVE HPY+ Q L FCK I L AY + G
Sbjct: 128 SIGVSNFNRRQLEMIL-NKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALG 186
Query: 176 G------TSCSNNSLLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKAVHPEHIKEN 229
++ LL DPV+ + A K + TPA + L + LQ+ V V+ K+ + + I++N
Sbjct: 187 SHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQN 246
>J04794-1|AAA51711.1| 325|Homo sapiens ALDR1 protein.
Length = 325
Score = 111 bits (267), Expect = 2e-24
Identities = 76/222 (34%), Positives = 116/222 (52%), Gaps = 19/222 (8%)
Query: 49 RMFAPSDHGSRAEQAYQKSLENLDLEYVDLYLIHFP-----GGAKLPAEDKR-----NTK 98
+++ H E A +K+L +L LEY+DLYL+H+P G P +T
Sbjct: 80 KLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTICYDSTH 139
Query: 99 MRELSWCKLTELYDDGKVNAVGVSNFTVAHLEGLMESNHGLVPAVNQVEWHPYYTQSSLY 158
+E +W L L G V A+G+SNF ++ ++ S + PAV QVE HPY Q+ L
Sbjct: 140 YKE-TWKALEALVAKGLVQALGLSNFNSRQIDDIL-SVASVRPAVLQVECHPYLAQNELI 197
Query: 159 KFCKQHHITLQAYCSFGGTSCSNNS-----LLNDPVVVSTALKLEVTPAQVLLVWALQQD 213
C+ + + AY G + + LL +PVV++ A K +PAQ+LL W +Q+
Sbjct: 198 AHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRK 257
Query: 214 VAVIPKAVHPEHIKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
V IPK++ P I +N + +F E+MK LN L+ KN +Y
Sbjct: 258 VICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALN-KNWRY 298
Score = 32.7 bits (71), Expect = 1.3
Identities = 17/37 (45%), Positives = 21/37 (56%), Gaps = 1/37 (2%)
Query: 13 VLNNGIMMPSIGLGTYRIRQSDIVMQVVDYALEAGYR 49
+L+ G MP IGLGT++ V V YAL GYR
Sbjct: 7 LLHTGQKMPLIGLGTWKSEPGQ-VKAAVKYALSVGYR 42
>CR457010-1|CAG33291.1| 325|Homo sapiens AKR1A1 protein.
Length = 325
Score = 111 bits (267), Expect = 2e-24
Identities = 76/222 (34%), Positives = 116/222 (52%), Gaps = 19/222 (8%)
Query: 49 RMFAPSDHGSRAEQAYQKSLENLDLEYVDLYLIHFP-----GGAKLPAEDKR-----NTK 98
+++ H E A +K+L +L LEY+DLYL+H+P G P +T
Sbjct: 80 KLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTICYDSTH 139
Query: 99 MRELSWCKLTELYDDGKVNAVGVSNFTVAHLEGLMESNHGLVPAVNQVEWHPYYTQSSLY 158
+E +W L L G V A+G+SNF ++ ++ S + PAV QVE HPY Q+ L
Sbjct: 140 YKE-TWKALEALVAKGLVQALGLSNFNSRQIDDIL-SVASVRPAVLQVECHPYLAQNELI 197
Query: 159 KFCKQHHITLQAYCSFGGTSCSNNS-----LLNDPVVVSTALKLEVTPAQVLLVWALQQD 213
C+ + + AY G + + LL +PVV++ A K +PAQ+LL W +Q+
Sbjct: 198 AHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRK 257
Query: 214 VAVIPKAVHPEHIKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
V IPK++ P I +N + +F E+MK LN L+ KN +Y
Sbjct: 258 VICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALN-KNWRY 298
Score = 32.7 bits (71), Expect = 1.3
Identities = 17/37 (45%), Positives = 21/37 (56%), Gaps = 1/37 (2%)
Query: 13 VLNNGIMMPSIGLGTYRIRQSDIVMQVVDYALEAGYR 49
+L+ G MP IGLGT++ V V YAL GYR
Sbjct: 7 LLHTGQKMPLIGLGTWKSEPGQ-VKAAVKYALSVGYR 42
>BT007003-1|AAP35649.1| 325|Homo sapiens aldo-keto reductase family
1, member A1 (aldehyde reductase) protein.
Length = 325
Score = 111 bits (267), Expect = 2e-24
Identities = 76/222 (34%), Positives = 116/222 (52%), Gaps = 19/222 (8%)
Query: 49 RMFAPSDHGSRAEQAYQKSLENLDLEYVDLYLIHFP-----GGAKLPAEDKR-----NTK 98
+++ H E A +K+L +L LEY+DLYL+H+P G P +T
Sbjct: 80 KLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTICYDSTH 139
Query: 99 MRELSWCKLTELYDDGKVNAVGVSNFTVAHLEGLMESNHGLVPAVNQVEWHPYYTQSSLY 158
+E +W L L G V A+G+SNF ++ ++ S + PAV QVE HPY Q+ L
Sbjct: 140 YKE-TWKALEALVAKGLVQALGLSNFNSRQIDDIL-SVASVRPAVLQVECHPYLAQNELI 197
Query: 159 KFCKQHHITLQAYCSFGGTSCSNNS-----LLNDPVVVSTALKLEVTPAQVLLVWALQQD 213
C+ + + AY G + + LL +PVV++ A K +PAQ+LL W +Q+
Sbjct: 198 AHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRK 257
Query: 214 VAVIPKAVHPEHIKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
V IPK++ P I +N + +F E+MK LN L+ KN +Y
Sbjct: 258 VICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALN-KNWRY 298
Score = 32.7 bits (71), Expect = 1.3
Identities = 17/37 (45%), Positives = 21/37 (56%), Gaps = 1/37 (2%)
Query: 13 VLNNGIMMPSIGLGTYRIRQSDIVMQVVDYALEAGYR 49
+L+ G MP IGLGT++ V V YAL GYR
Sbjct: 7 LLHTGQKMPLIGLGTWKSEPGQ-VKAAVKYALSVGYR 42
>BC005394-1|AAH05394.1| 325|Homo sapiens aldo-keto reductase family
1, member A1 (aldehyde reductase) protein.
Length = 325
Score = 111 bits (267), Expect = 2e-24
Identities = 76/222 (34%), Positives = 116/222 (52%), Gaps = 19/222 (8%)
Query: 49 RMFAPSDHGSRAEQAYQKSLENLDLEYVDLYLIHFP-----GGAKLPAEDKR-----NTK 98
+++ H E A +K+L +L LEY+DLYL+H+P G P +T
Sbjct: 80 KLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTICYDSTH 139
Query: 99 MRELSWCKLTELYDDGKVNAVGVSNFTVAHLEGLMESNHGLVPAVNQVEWHPYYTQSSLY 158
+E +W L L G V A+G+SNF ++ ++ S + PAV QVE HPY Q+ L
Sbjct: 140 YKE-TWKALEALVAKGLVQALGLSNFNSRQIDDIL-SVASVRPAVLQVECHPYLAQNELI 197
Query: 159 KFCKQHHITLQAYCSFGGTSCSNNS-----LLNDPVVVSTALKLEVTPAQVLLVWALQQD 213
C+ + + AY G + + LL +PVV++ A K +PAQ+LL W +Q+
Sbjct: 198 AHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRK 257
Query: 214 VAVIPKAVHPEHIKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
V IPK++ P I +N + +F E+MK LN L+ KN +Y
Sbjct: 258 VICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALN-KNWRY 298
Score = 32.7 bits (71), Expect = 1.3
Identities = 17/37 (45%), Positives = 21/37 (56%), Gaps = 1/37 (2%)
Query: 13 VLNNGIMMPSIGLGTYRIRQSDIVMQVVDYALEAGYR 49
+L+ G MP IGLGT++ V V YAL GYR
Sbjct: 7 LLHTGQKMPLIGLGTWKSEPGQ-VKAAVKYALSVGYR 42
>BC000670-1|AAH00670.1| 325|Homo sapiens aldo-keto reductase family
1, member A1 (aldehyde reductase) protein.
Length = 325
Score = 111 bits (267), Expect = 2e-24
Identities = 76/222 (34%), Positives = 116/222 (52%), Gaps = 19/222 (8%)
Query: 49 RMFAPSDHGSRAEQAYQKSLENLDLEYVDLYLIHFP-----GGAKLPAEDKR-----NTK 98
+++ H E A +K+L +L LEY+DLYL+H+P G P +T
Sbjct: 80 KLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTICYDSTH 139
Query: 99 MRELSWCKLTELYDDGKVNAVGVSNFTVAHLEGLMESNHGLVPAVNQVEWHPYYTQSSLY 158
+E +W L L G V A+G+SNF ++ ++ S + PAV QVE HPY Q+ L
Sbjct: 140 YKE-TWKALEALVAKGLVQALGLSNFNSRQIDDIL-SVASVRPAVLQVECHPYLAQNELI 197
Query: 159 KFCKQHHITLQAYCSFGGTSCSNNS-----LLNDPVVVSTALKLEVTPAQVLLVWALQQD 213
C+ + + AY G + + LL +PVV++ A K +PAQ+LL W +Q+
Sbjct: 198 AHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRK 257
Query: 214 VAVIPKAVHPEHIKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
V IPK++ P I +N + +F E+MK LN L+ KN +Y
Sbjct: 258 VICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALN-KNWRY 298
Score = 32.7 bits (71), Expect = 1.3
Identities = 17/37 (45%), Positives = 21/37 (56%), Gaps = 1/37 (2%)
Query: 13 VLNNGIMMPSIGLGTYRIRQSDIVMQVVDYALEAGYR 49
+L+ G MP IGLGT++ V V YAL GYR
Sbjct: 7 LLHTGQKMPLIGLGTWKSEPGQ-VKAAVKYALSVGYR 42
>AL355480-3|CAI22459.1| 325|Homo sapiens aldo-keto reductase family
1, member A1 (aldehydetase, 1 protein.
Length = 325
Score = 111 bits (267), Expect = 2e-24
Identities = 76/222 (34%), Positives = 116/222 (52%), Gaps = 19/222 (8%)
Query: 49 RMFAPSDHGSRAEQAYQKSLENLDLEYVDLYLIHFP-----GGAKLPAEDKR-----NTK 98
+++ H E A +K+L +L LEY+DLYL+H+P G P +T
Sbjct: 80 KLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTICYDSTH 139
Query: 99 MRELSWCKLTELYDDGKVNAVGVSNFTVAHLEGLMESNHGLVPAVNQVEWHPYYTQSSLY 158
+E +W L L G V A+G+SNF ++ ++ S + PAV QVE HPY Q+ L
Sbjct: 140 YKE-TWKALEALVAKGLVQALGLSNFNSRQIDDIL-SVASVRPAVLQVECHPYLAQNELI 197
Query: 159 KFCKQHHITLQAYCSFGGTSCSNNS-----LLNDPVVVSTALKLEVTPAQVLLVWALQQD 213
C+ + + AY G + + LL +PVV++ A K +PAQ+LL W +Q+
Sbjct: 198 AHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRK 257
Query: 214 VAVIPKAVHPEHIKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
V IPK++ P I +N + +F E+MK LN L+ KN +Y
Sbjct: 258 VICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALN-KNWRY 298
Score = 32.7 bits (71), Expect = 1.3
Identities = 17/37 (45%), Positives = 21/37 (56%), Gaps = 1/37 (2%)
Query: 13 VLNNGIMMPSIGLGTYRIRQSDIVMQVVDYALEAGYR 49
+L+ G MP IGLGT++ V V YAL GYR
Sbjct: 7 LLHTGQKMPLIGLGTWKSEPGQ-VKAAVKYALSVGYR 42
>AF112485-1|AAF01260.1| 325|Homo sapiens aldehyde reductase
protein.
Length = 325
Score = 111 bits (267), Expect = 2e-24
Identities = 76/222 (34%), Positives = 116/222 (52%), Gaps = 19/222 (8%)
Query: 49 RMFAPSDHGSRAEQAYQKSLENLDLEYVDLYLIHFP-----GGAKLPAEDKR-----NTK 98
+++ H E A +K+L +L LEY+DLYL+H+P G P +T
Sbjct: 80 KLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTICYDSTH 139
Query: 99 MRELSWCKLTELYDDGKVNAVGVSNFTVAHLEGLMESNHGLVPAVNQVEWHPYYTQSSLY 158
+E +W L L G V A+G+SNF ++ ++ S + PAV QVE HPY Q+ L
Sbjct: 140 YKE-TWKALEALVAKGLVQALGLSNFNSRQIDDIL-SVASVRPAVLQVECHPYLAQNELI 197
Query: 159 KFCKQHHITLQAYCSFGGTSCSNNS-----LLNDPVVVSTALKLEVTPAQVLLVWALQQD 213
C+ + + AY G + + LL +PVV++ A K +PAQ+LL W +Q+
Sbjct: 198 AHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRK 257
Query: 214 VAVIPKAVHPEHIKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
V IPK++ P I +N + +F E+MK LN L+ KN +Y
Sbjct: 258 VICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALN-KNWRY 298
Score = 32.7 bits (71), Expect = 1.3
Identities = 17/37 (45%), Positives = 21/37 (56%), Gaps = 1/37 (2%)
Query: 13 VLNNGIMMPSIGLGTYRIRQSDIVMQVVDYALEAGYR 49
+L+ G MP IGLGT++ V V YAL GYR
Sbjct: 7 LLHTGQKMPLIGLGTWKSEPGQ-VKAAVKYALSVGYR 42
>AF036683-1|AAB92369.1| 325|Homo sapiens aldehyde reductase
protein.
Length = 325
Score = 111 bits (267), Expect = 2e-24
Identities = 76/222 (34%), Positives = 116/222 (52%), Gaps = 19/222 (8%)
Query: 49 RMFAPSDHGSRAEQAYQKSLENLDLEYVDLYLIHFP-----GGAKLPAEDKR-----NTK 98
+++ H E A +K+L +L LEY+DLYL+H+P G P +T
Sbjct: 80 KLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTICYDSTH 139
Query: 99 MRELSWCKLTELYDDGKVNAVGVSNFTVAHLEGLMESNHGLVPAVNQVEWHPYYTQSSLY 158
+E +W L L G V A+G+SNF ++ ++ S + PAV QVE HPY Q+ L
Sbjct: 140 YKE-TWKALEALVAKGLVQALGLSNFNSRQIDDIL-SVASVRPAVLQVECHPYLAQNELI 197
Query: 159 KFCKQHHITLQAYCSFGGTSCSNNS-----LLNDPVVVSTALKLEVTPAQVLLVWALQQD 213
C+ + + AY G + + LL +PVV++ A K +PAQ+LL W +Q+
Sbjct: 198 AHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRK 257
Query: 214 VAVIPKAVHPEHIKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
V IPK++ P I +N + +F E+MK LN L+ KN +Y
Sbjct: 258 VICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALN-KNWRY 298
Score = 32.7 bits (71), Expect = 1.3
Identities = 17/37 (45%), Positives = 21/37 (56%), Gaps = 1/37 (2%)
Query: 13 VLNNGIMMPSIGLGTYRIRQSDIVMQVVDYALEAGYR 49
+L+ G MP IGLGT++ V V YAL GYR
Sbjct: 7 LLHTGQKMPLIGLGTWKSEPGQ-VKAAVKYALSVGYR 42
>Z28339-1|CAA82193.1| 326|Homo sapiens delta 4-3-oxosteroid 5
beta-reductase protein.
Length = 326
Score = 111 bits (266), Expect = 3e-24
Identities = 76/208 (36%), Positives = 113/208 (54%), Gaps = 20/208 (9%)
Query: 65 QKSLENLDLEYVDLYLIHFP-----GGAKLPAEDKRNTKMRELSWCKLTELY----DDGK 115
+++L L L+YVDLY+I P G P ++ + + C E D G
Sbjct: 103 ERTLRVLQLDYVDLYIIEVPMAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGL 162
Query: 116 VNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSLYKFCKQHHITLQAYCS 173
V ++GVSNF LE L+ + GL P NQVE HPY+TQ L KFC+QH I + AY
Sbjct: 163 VKSLGVSNFNRRQLE-LILNKPGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSP 221
Query: 174 FGGT------SCSNNSLLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKAVHPEHIK 227
G + + S+ LL D ++ S + T AQ++L + +Q+ V VIPK+ + E IK
Sbjct: 222 LGTSRNPIWVNVSSPPLLKDALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIK 281
Query: 228 EN-RSLNFKIPEEDMKALNQLSEKNVKY 254
EN + +F + EE+MK + L+ KNV++
Sbjct: 282 ENFQIFDFSLTEEEMKDIEALN-KNVRF 308
>DQ269985-1|ABB76132.1| 323|Homo sapiens type II 3a-hydroxysteroid
dehydrogenase variant protein.
Length = 323
Score = 111 bits (266), Expect = 3e-24
Identities = 76/224 (33%), Positives = 119/224 (53%), Gaps = 20/224 (8%)
Query: 49 RMFAPSDHGSRAEQAYQKSLENLDLEYVDLYLIHFP----GGAKLPAEDKRNTKMREL-- 102
+++ S A ++SL+ L+YVDLYLIH P G +L D+ + ++
Sbjct: 84 KLWCNSHRPELVRPALERSLKKAQLDYVDLYLIHSPMSLKPGEELSPTDENGKVIFDIVD 143
Query: 103 ---SWCKLTELYDDGKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSL 157
+W + + D G ++GVSNF LE ++ + GL P NQVE HPY+ +S L
Sbjct: 144 LCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMIL-NKPGLKYKPVCNQVECHPYFNRSKL 202
Query: 158 YKFCKQHHITLQAYCSFGGTS----CSNNS--LLNDPVVVSTALKLEVTPAQVLLVWALQ 211
FCK I L AY + G NS LL DPV+ + A K + TPA + L + LQ
Sbjct: 203 LDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQ 262
Query: 212 QDVAVIPKAVHPEHIKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
+ V V+ K+ + + I++N + F++ EDMKA++ L ++N+ Y
Sbjct: 263 RGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGL-DRNLHY 305
>BC130627-1|AAI30628.1| 326|Homo sapiens aldo-keto reductase family
1, member D1 (delta 4-3-ketosteroid-5-beta-reductase
protein.
Length = 326
Score = 111 bits (266), Expect = 3e-24
Identities = 76/208 (36%), Positives = 113/208 (54%), Gaps = 20/208 (9%)
Query: 65 QKSLENLDLEYVDLYLIHFP-----GGAKLPAEDKRNTKMRELSWCKLTELY----DDGK 115
+++L L L+YVDLY+I P G P ++ + + C E D G
Sbjct: 103 ERTLRVLQLDYVDLYIIEVPMAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGL 162
Query: 116 VNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSLYKFCKQHHITLQAYCS 173
V ++GVSNF LE L+ + GL P NQVE HPY+TQ L KFC+QH I + AY
Sbjct: 163 VKSLGVSNFNRRQLE-LILNKPGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSP 221
Query: 174 FGGT------SCSNNSLLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKAVHPEHIK 227
G + + S+ LL D ++ S + T AQ++L + +Q+ V VIPK+ + E IK
Sbjct: 222 LGTSRNPIWVNVSSPPLLKDALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIK 281
Query: 228 EN-RSLNFKIPEEDMKALNQLSEKNVKY 254
EN + +F + EE+MK + L+ KNV++
Sbjct: 282 ENFQIFDFSLTEEEMKDIEALN-KNVRF 308
>BC130625-1|AAI30626.1| 326|Homo sapiens aldo-keto reductase family
1, member D1 (delta 4-3-ketosteroid-5-beta-reductase
protein.
Length = 326
Score = 111 bits (266), Expect = 3e-24
Identities = 76/208 (36%), Positives = 113/208 (54%), Gaps = 20/208 (9%)
Query: 65 QKSLENLDLEYVDLYLIHFP-----GGAKLPAEDKRNTKMRELSWCKLTELY----DDGK 115
+++L L L+YVDLY+I P G P ++ + + C E D G
Sbjct: 103 ERTLRVLQLDYVDLYIIEVPMAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGL 162
Query: 116 VNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSLYKFCKQHHITLQAYCS 173
V ++GVSNF LE L+ + GL P NQVE HPY+TQ L KFC+QH I + AY
Sbjct: 163 VKSLGVSNFNRRQLE-LILNKPGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSP 221
Query: 174 FGGT------SCSNNSLLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKAVHPEHIK 227
G + + S+ LL D ++ S + T AQ++L + +Q+ V VIPK+ + E IK
Sbjct: 222 LGTSRNPIWVNVSSPPLLKDALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIK 281
Query: 228 EN-RSLNFKIPEEDMKALNQLSEKNVKY 254
EN + +F + EE+MK + L+ KNV++
Sbjct: 282 ENFQIFDFSLTEEEMKDIEALN-KNVRF 308
>AF283659-1|AAG39381.1| 326|Homo sapiens 5-beta steroid reductase
protein.
Length = 326
Score = 111 bits (266), Expect = 3e-24
Identities = 76/208 (36%), Positives = 113/208 (54%), Gaps = 20/208 (9%)
Query: 65 QKSLENLDLEYVDLYLIHFP-----GGAKLPAEDKRNTKMRELSWCKLTELY----DDGK 115
+++L L L+YVDLY+I P G P ++ + + C E D G
Sbjct: 103 ERTLRVLQLDYVDLYIIEVPMAFKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGL 162
Query: 116 VNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSLYKFCKQHHITLQAYCS 173
V ++GVSNF LE L+ + GL P NQVE HPY+TQ L KFC+QH I + AY
Sbjct: 163 VKSLGVSNFNRRQLE-LILNKPGLKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSP 221
Query: 174 FGGT------SCSNNSLLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKAVHPEHIK 227
G + + S+ LL D ++ S + T AQ++L + +Q+ V VIPK+ + E IK
Sbjct: 222 LGTSRNPIWVNVSSPPLLKDALLNSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIK 281
Query: 228 EN-RSLNFKIPEEDMKALNQLSEKNVKY 254
EN + +F + EE+MK + L+ KNV++
Sbjct: 282 ENFQIFDFSLTEEEMKDIEALN-KNVRF 308
>D17793-1|BAA04619.2| 325|Homo sapiens KIAA0119 protein.
Length = 325
Score = 109 bits (263), Expect = 7e-24
Identities = 75/210 (35%), Positives = 114/210 (54%), Gaps = 20/210 (9%)
Query: 63 AYQKSLENLDLEYVDLYLIHFP----GGAKLPAEDKRNTKMREL-----SWCKLTELYDD 113
A + SL+ L+YVDLYLIH P G +L D+ + ++ +W + + D
Sbjct: 100 ALENSLKKAQLDYVDLYLIHSPMSLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDA 159
Query: 114 GKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSLYKFCKQHHITLQAY 171
G ++GVSNF LE ++ + GL P NQVE HPY+ +S L FCK I L AY
Sbjct: 160 GLAKSIGVSNFNRRQLEMIL-NKPGLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAY 218
Query: 172 CSFGGTS----CSNNS--LLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKAVHPEH 225
+ G NS LL DPV+ + A K + TPA + L + LQ+ V V+ K+ + +
Sbjct: 219 SALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQR 278
Query: 226 IKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
I++N + F++ EDMKA++ L ++N+ Y
Sbjct: 279 IRQNVQVFEFQLTAEDMKAIDGL-DRNLHY 307
Score = 29.9 bits (64), Expect = 9.4
Identities = 15/38 (39%), Positives = 22/38 (57%), Gaps = 2/38 (5%)
Query: 14 LNNGIMMPSIGLGTYRIRQ--SDIVMQVVDYALEAGYR 49
LN+G MP +G GTY + ++V A+EAG+R
Sbjct: 12 LNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFR 49
>BT007286-1|AAP35950.1| 323|Homo sapiens aldo-keto reductase family
1, member C3 (3-alpha hydroxysteroid dehydrogenase,
protein.
Length = 323
Score = 109 bits (263), Expect = 7e-24
Identities = 75/210 (35%), Positives = 114/210 (54%), Gaps = 20/210 (9%)
Query: 63 AYQKSLENLDLEYVDLYLIHFP----GGAKLPAEDKRNTKMREL-----SWCKLTELYDD 113
A + SL+ L+YVDLYLIH P G +L D+ + ++ +W + + D
Sbjct: 98 ALENSLKKAQLDYVDLYLIHSPMSLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDA 157
Query: 114 GKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSLYKFCKQHHITLQAY 171
G ++GVSNF LE ++ + GL P NQVE HPY+ +S L FCK I L AY
Sbjct: 158 GLAKSIGVSNFNRRQLEMIL-NKPGLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAY 216
Query: 172 CSFGGTS----CSNNS--LLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKAVHPEH 225
+ G NS LL DPV+ + A K + TPA + L + LQ+ V V+ K+ + +
Sbjct: 217 SALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQR 276
Query: 226 IKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
I++N + F++ EDMKA++ L ++N+ Y
Sbjct: 277 IRQNVQVFEFQLTAEDMKAIDGL-DRNLHY 305
Score = 29.9 bits (64), Expect = 9.4
Identities = 15/38 (39%), Positives = 22/38 (57%), Gaps = 2/38 (5%)
Query: 14 LNNGIMMPSIGLGTYRIRQ--SDIVMQVVDYALEAGYR 49
LN+G MP +G GTY + ++V A+EAG+R
Sbjct: 10 LNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFR 47
>BC019230-1|AAH19230.1| 323|Homo sapiens aldo-keto reductase family
1, member C3 (3-alpha hydroxysteroid dehydrogenase,
protein.
Length = 323
Score = 109 bits (263), Expect = 7e-24
Identities = 75/210 (35%), Positives = 114/210 (54%), Gaps = 20/210 (9%)
Query: 63 AYQKSLENLDLEYVDLYLIHFP----GGAKLPAEDKRNTKMREL-----SWCKLTELYDD 113
A + SL+ L+YVDLYLIH P G +L D+ + ++ +W + + D
Sbjct: 98 ALENSLKKAQLDYVDLYLIHSPMSLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDA 157
Query: 114 GKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSLYKFCKQHHITLQAY 171
G ++GVSNF LE ++ + GL P NQVE HPY+ +S L FCK I L AY
Sbjct: 158 GLAKSIGVSNFNRRQLEMIL-NKPGLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAY 216
Query: 172 CSFGGTS----CSNNS--LLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKAVHPEH 225
+ G NS LL DPV+ + A K + TPA + L + LQ+ V V+ K+ + +
Sbjct: 217 SALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQR 276
Query: 226 IKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
I++N + F++ EDMKA++ L ++N+ Y
Sbjct: 277 IRQNVQVFEFQLTAEDMKAIDGL-DRNLHY 305
Score = 29.9 bits (64), Expect = 9.4
Identities = 15/38 (39%), Positives = 22/38 (57%), Gaps = 2/38 (5%)
Query: 14 LNNGIMMPSIGLGTYRIRQ--SDIVMQVVDYALEAGYR 49
LN+G MP +G GTY + ++V A+EAG+R
Sbjct: 10 LNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFR 47
>BC001479-1|AAH01479.1| 323|Homo sapiens aldo-keto reductase family
1, member C3 (3-alpha hydroxysteroid dehydrogenase,
protein.
Length = 323
Score = 109 bits (263), Expect = 7e-24
Identities = 75/210 (35%), Positives = 114/210 (54%), Gaps = 20/210 (9%)
Query: 63 AYQKSLENLDLEYVDLYLIHFP----GGAKLPAEDKRNTKMREL-----SWCKLTELYDD 113
A + SL+ L+YVDLYLIH P G +L D+ + ++ +W + + D
Sbjct: 98 ALENSLKKAQLDYVDLYLIHSPMSLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDA 157
Query: 114 GKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSLYKFCKQHHITLQAY 171
G ++GVSNF LE ++ + GL P NQVE HPY+ +S L FCK I L AY
Sbjct: 158 GLAKSIGVSNFNRRQLEMIL-NKPGLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAY 216
Query: 172 CSFGGTS----CSNNS--LLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKAVHPEH 225
+ G NS LL DPV+ + A K + TPA + L + LQ+ V V+ K+ + +
Sbjct: 217 SALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQR 276
Query: 226 IKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
I++N + F++ EDMKA++ L ++N+ Y
Sbjct: 277 IRQNVQVFEFQLTAEDMKAIDGL-DRNLHY 305
Score = 29.9 bits (64), Expect = 9.4
Identities = 15/38 (39%), Positives = 22/38 (57%), Gaps = 2/38 (5%)
Query: 14 LNNGIMMPSIGLGTYRIRQ--SDIVMQVVDYALEAGYR 49
LN+G MP +G GTY + ++V A+EAG+R
Sbjct: 10 LNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFR 47
>AL391427-4|CAI14729.1| 323|Homo sapiens aldo-keto reductase family
1, member C3 (3-alpha hydroxysteroid dehydrogenase,
protein.
Length = 323
Score = 109 bits (263), Expect = 7e-24
Identities = 75/210 (35%), Positives = 114/210 (54%), Gaps = 20/210 (9%)
Query: 63 AYQKSLENLDLEYVDLYLIHFP----GGAKLPAEDKRNTKMREL-----SWCKLTELYDD 113
A + SL+ L+YVDLYLIH P G +L D+ + ++ +W + + D
Sbjct: 98 ALENSLKKAQLDYVDLYLIHSPMSLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDA 157
Query: 114 GKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSLYKFCKQHHITLQAY 171
G ++GVSNF LE ++ + GL P NQVE HPY+ +S L FCK I L AY
Sbjct: 158 GLAKSIGVSNFNRRQLEMIL-NKPGLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAY 216
Query: 172 CSFGGTS----CSNNS--LLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKAVHPEH 225
+ G NS LL DPV+ + A K + TPA + L + LQ+ V V+ K+ + +
Sbjct: 217 SALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQR 276
Query: 226 IKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
I++N + F++ EDMKA++ L ++N+ Y
Sbjct: 277 IRQNVQVFEFQLTAEDMKAIDGL-DRNLHY 305
Score = 29.9 bits (64), Expect = 9.4
Identities = 15/38 (39%), Positives = 22/38 (57%), Gaps = 2/38 (5%)
Query: 14 LNNGIMMPSIGLGTYRIRQ--SDIVMQVVDYALEAGYR 49
LN+G MP +G GTY + ++V A+EAG+R
Sbjct: 10 LNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFR 47
>AF149416-1|AAF07272.2| 323|Homo sapiens 3-alpha hydroxysteroid
dehydrogenase type IIb protein.
Length = 323
Score = 109 bits (263), Expect = 7e-24
Identities = 75/224 (33%), Positives = 119/224 (53%), Gaps = 20/224 (8%)
Query: 49 RMFAPSDHGSRAEQAYQKSLENLDLEYVDLYLIHFP----GGAKLPAEDKRNTKMREL-- 102
++++ S A + SL+ L+YVDLYLIH P G +L D+ + ++
Sbjct: 84 KLWSTSHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPGEELSPTDENGKVIFDIVD 143
Query: 103 ---SWCKLTELYDDGKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSL 157
+W + + D G ++GVSNF LE ++ + GL P NQVE HPY+ +S L
Sbjct: 144 LCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMIL-NKPGLKYKPVCNQVECHPYFNRSKL 202
Query: 158 YKFCKQHHITLQAYCSFGGTS----CSNNS--LLNDPVVVSTALKLEVTPAQVLLVWALQ 211
FCK I L AY + G NS LL DPV+ + A K + TPA + L + LQ
Sbjct: 203 LDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQ 262
Query: 212 QDVAVIPKAVHPEHIKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
+ V V+ ++ + + I++N + F++ EDMKA++ L ++N+ Y
Sbjct: 263 RGVVVLARSYNEQRIRQNVQVFEFQLTAEDMKAIDGL-DRNLHY 305
>AB032157-1|BAA92892.1| 323|Homo sapiens prostaglandin F synthase
protein.
Length = 323
Score = 109 bits (263), Expect = 7e-24
Identities = 75/210 (35%), Positives = 114/210 (54%), Gaps = 20/210 (9%)
Query: 63 AYQKSLENLDLEYVDLYLIHFP----GGAKLPAEDKRNTKMREL-----SWCKLTELYDD 113
A + SL+ L+YVDLYLIH P G +L D+ + ++ +W + + D
Sbjct: 98 ALENSLKKAQLDYVDLYLIHSPMSLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDA 157
Query: 114 GKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSLYKFCKQHHITLQAY 171
G ++GVSNF LE ++ + GL P NQVE HPY+ +S L FCK I L AY
Sbjct: 158 GLAKSIGVSNFNRRQLEMIL-NKPGLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAY 216
Query: 172 CSFGGTS----CSNNS--LLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKAVHPEH 225
+ G NS LL DPV+ + A K + TPA + L + LQ+ V V+ K+ + +
Sbjct: 217 SALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQR 276
Query: 226 IKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
I++N + F++ EDMKA++ L ++N+ Y
Sbjct: 277 IRQNVQVFEFQLTAEDMKAIDGL-DRNLHY 305
Score = 29.9 bits (64), Expect = 9.4
Identities = 15/38 (39%), Positives = 22/38 (57%), Gaps = 2/38 (5%)
Query: 14 LNNGIMMPSIGLGTYRIRQ--SDIVMQVVDYALEAGYR 49
LN+G MP +G GTY + ++V A+EAG+R
Sbjct: 10 LNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFR 47
>AB018580-1|BAA88488.1| 323|Homo sapiens hluPGFS protein.
Length = 323
Score = 109 bits (263), Expect = 7e-24
Identities = 75/210 (35%), Positives = 114/210 (54%), Gaps = 20/210 (9%)
Query: 63 AYQKSLENLDLEYVDLYLIHFP----GGAKLPAEDKRNTKMREL-----SWCKLTELYDD 113
A + SL+ L+YVDLYLIH P G +L D+ + ++ +W + + D
Sbjct: 98 ALENSLKKAQLDYVDLYLIHSPMSLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDA 157
Query: 114 GKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSLYKFCKQHHITLQAY 171
G ++GVSNF LE ++ + GL P NQVE HPY+ +S L FCK I L AY
Sbjct: 158 GLAKSIGVSNFNRRQLEMIL-NKPGLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAY 216
Query: 172 CSFGGTS----CSNNS--LLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKAVHPEH 225
+ G NS LL DPV+ + A K + TPA + L + LQ+ V V+ K+ + +
Sbjct: 217 SALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQR 276
Query: 226 IKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
I++N + F++ EDMKA++ L ++N+ Y
Sbjct: 277 IRQNVQVFEFQLTAEDMKAIDGL-DRNLHY 305
Score = 29.9 bits (64), Expect = 9.4
Identities = 15/38 (39%), Positives = 22/38 (57%), Gaps = 2/38 (5%)
Query: 14 LNNGIMMPSIGLGTYRIRQ--SDIVMQVVDYALEAGYR 49
LN+G MP +G GTY + ++V A+EAG+R
Sbjct: 10 LNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFR 47
>S68288-1|AAD14011.1| 323|Homo sapiens chlordecone reductase
homolog protein.
Length = 323
Score = 109 bits (262), Expect = 1e-23
Identities = 75/210 (35%), Positives = 114/210 (54%), Gaps = 20/210 (9%)
Query: 63 AYQKSLENLDLEYVDLYLIHFP----GGAKLPAEDKRNTKMREL-----SWCKLTELYDD 113
A + SL+ L+YVDLYLIH P G +L D+ + ++ +W + + D
Sbjct: 98 ALENSLKKAQLDYVDLYLIHSPMSLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDA 157
Query: 114 GKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSLYKFCKQHHITLQAY 171
G ++GVSNF LE ++ + GL P NQVE HPY+ +S L FCK I L AY
Sbjct: 158 GLAKSIGVSNFNRRQLEIIL-NKPGLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAY 216
Query: 172 CSFGGTS----CSNNS--LLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKAVHPEH 225
+ G NS LL DPV+ + A K + TPA + L + LQ+ V V+ K+ + +
Sbjct: 217 SALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQR 276
Query: 226 IKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
I++N + F++ EDMKA++ L ++N+ Y
Sbjct: 277 IRQNVQVFEFQLTAEDMKAIDGL-DRNLHY 305
Score = 29.9 bits (64), Expect = 9.4
Identities = 15/38 (39%), Positives = 22/38 (57%), Gaps = 2/38 (5%)
Query: 14 LNNGIMMPSIGLGTYRIRQ--SDIVMQVVDYALEAGYR 49
LN+G MP +G GTY + ++V A+EAG+R
Sbjct: 10 LNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFR 47
>L43839-1|AAB41916.1| 323|Homo sapiens 3-alpha-hydroxysteroid
dehydrogenase protein.
Length = 323
Score = 109 bits (262), Expect = 1e-23
Identities = 75/210 (35%), Positives = 114/210 (54%), Gaps = 20/210 (9%)
Query: 63 AYQKSLENLDLEYVDLYLIHFP----GGAKLPAEDKRNTKMREL-----SWCKLTELYDD 113
A + SL+ L+YVDLYLIH P G +L D+ + ++ +W + + D
Sbjct: 98 ALENSLKKAQLDYVDLYLIHSPMSLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDA 157
Query: 114 GKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSLYKFCKQHHITLQAY 171
G ++GVSNF LE ++ + GL P NQVE HPY+ +S L FCK I L AY
Sbjct: 158 GLAKSIGVSNFNRRQLEIIL-NKPGLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAY 216
Query: 172 CSFGGTS----CSNNS--LLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKAVHPEH 225
+ G NS LL DPV+ + A K + TPA + L + LQ+ V V+ K+ + +
Sbjct: 217 SALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQR 276
Query: 226 IKEN-RSLNFKIPEEDMKALNQLSEKNVKY 254
I++N + F++ EDMKA++ L ++N+ Y
Sbjct: 277 IRQNVQVFEFQLTAEDMKAIDGL-DRNLHY 305
Score = 29.9 bits (64), Expect = 9.4
Identities = 15/38 (39%), Positives = 22/38 (57%), Gaps = 2/38 (5%)
Query: 14 LNNGIMMPSIGLGTYRIRQ--SDIVMQVVDYALEAGYR 49
LN+G MP +G GTY + ++V A+EAG+R
Sbjct: 10 LNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFR 47
>BC002862-1|AAH02862.1| 307|Homo sapiens AKR1CL2 protein protein.
Length = 307
Score = 103 bits (247), Expect = 6e-22
Identities = 58/159 (36%), Positives = 94/159 (59%), Gaps = 6/159 (3%)
Query: 103 SWCKLTELYDDGKVNAVGVSNFTVAHLEGLMESNHGL--VPAVNQVEWHPYYTQSSLYKF 160
+W + +L G V +GVSNF LE L+ + GL P NQ+E HPY TQ +L F
Sbjct: 151 TWEAMEDLVITGLVKNIGVSNFNHEQLERLL-NKPGLRFKPLTNQIECHPYLTQKNLISF 209
Query: 161 CKQHHITLQAYCSFGGTSCSNNSLLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKA 220
C+ +++ AY GG SC L+++PV+ A + +PAQ+L+ + +Q++V VIP +
Sbjct: 210 CQSRDVSVTAYRPLGG-SCEGVDLIDNPVIKRIAKEHGKSPAQILIRFQIQRNVIVIPGS 268
Query: 221 VHPEHIKEN-RSLNFKIPEEDMKALNQLSEKNVKYAWDP 258
+ P HIKEN + +F++ + DM + L+ +N++ A P
Sbjct: 269 ITPSHIKENIQVFDFELTQHDMDNILSLN-RNLRLAMFP 306
Score = 41.1 bits (92), Expect = 0.004
Identities = 23/48 (47%), Positives = 29/48 (60%), Gaps = 1/48 (2%)
Query: 58 SRAEQAYQKSLENLDLEYVDLYLIHFPGGAKLPAEDKRNTKMRELSWC 105
S E A +KSL+ L L Y+DLYLIH+P G K P + ELS+C
Sbjct: 78 SLVETACRKSLKALKLNYLDLYLIHWPMGFK-PPHPEWIMSCSELSFC 124
>AF263242-1|AAK58523.1| 320|Homo sapiens aldo-keto reductase
loopADR protein.
Length = 320
Score = 103 bits (247), Expect = 6e-22
Identities = 58/159 (36%), Positives = 94/159 (59%), Gaps = 6/159 (3%)
Query: 103 SWCKLTELYDDGKVNAVGVSNFTVAHLEGLMESNHGL--VPAVNQVEWHPYYTQSSLYKF 160
+W + +L G V +GVSNF LE L+ + GL P NQ+E HPY TQ +L F
Sbjct: 151 TWEAMEDLVITGLVKNIGVSNFNHEQLERLL-NKPGLRFKPLTNQIECHPYLTQKNLISF 209
Query: 161 CKQHHITLQAYCSFGGTSCSNNSLLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKA 220
C+ +++ AY GG SC L+++PV+ A + +PAQ+L+ + +Q++V VIP +
Sbjct: 210 CQSRDVSVTAYRPLGG-SCEGVDLIDNPVIKRIAKEHGKSPAQILIRFQIQRNVIVIPGS 268
Query: 221 VHPEHIKEN-RSLNFKIPEEDMKALNQLSEKNVKYAWDP 258
+ P HIKEN + +F++ + DM + L+ +N++ A P
Sbjct: 269 ITPSHIKENIQVFDFELTQHDMDNILSLN-RNLRLAMFP 306
Score = 41.1 bits (92), Expect = 0.004
Identities = 23/48 (47%), Positives = 29/48 (60%), Gaps = 1/48 (2%)
Query: 58 SRAEQAYQKSLENLDLEYVDLYLIHFPGGAKLPAEDKRNTKMRELSWC 105
S E A +KSL+ L L Y+DLYLIH+P G K P + ELS+C
Sbjct: 78 SLVETACRKSLKALKLNYLDLYLIHWPMGFK-PPHPEWIMSCSELSFC 124
>AB055603-1|BAC54568.1| 307|Homo sapiens aldo-keto reductase
related protein 4 protein.
Length = 307
Score = 103 bits (247), Expect = 6e-22
Identities = 58/159 (36%), Positives = 94/159 (59%), Gaps = 6/159 (3%)
Query: 103 SWCKLTELYDDGKVNAVGVSNFTVAHLEGLMESNHGL--VPAVNQVEWHPYYTQSSLYKF 160
+W + +L G V +GVSNF LE L+ + GL P NQ+E HPY TQ +L F
Sbjct: 151 TWEAMEDLVITGLVKNIGVSNFNHEQLERLL-NKPGLRFKPLTNQIECHPYLTQKNLISF 209
Query: 161 CKQHHITLQAYCSFGGTSCSNNSLLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKA 220
C+ +++ AY GG SC L+++PV+ A + +PAQ+L+ + +Q++V VIP +
Sbjct: 210 CQSRDVSVTAYRPLGG-SCEGVDLIDNPVIKRIAKEHGKSPAQILIRFQIQRNVIVIPGS 268
Query: 221 VHPEHIKEN-RSLNFKIPEEDMKALNQLSEKNVKYAWDP 258
+ P HIKEN + +F++ + DM + L+ +N++ A P
Sbjct: 269 ITPSHIKENIQVFDFELTQHDMDNILSLN-RNLRLAMFP 306
Score = 41.1 bits (92), Expect = 0.004
Identities = 23/48 (47%), Positives = 29/48 (60%), Gaps = 1/48 (2%)
Query: 58 SRAEQAYQKSLENLDLEYVDLYLIHFPGGAKLPAEDKRNTKMRELSWC 105
S E A +KSL+ L L Y+DLYLIH+P G K P + ELS+C
Sbjct: 78 SLVETACRKSLKALKLNYLDLYLIHWPMGFK-PPHPEWIMSCSELSFC 124
>AB209796-1|BAD93033.1| 260|Homo sapiens aldo-keto reductase family
1, member B1 variant protein.
Length = 260
Score = 95.5 bits (227), Expect = 2e-19
Identities = 60/158 (37%), Positives = 85/158 (53%), Gaps = 17/158 (10%)
Query: 63 AYQKSLENLDLEYVDLYLIHFPGGAK-----LPAEDKRNTKMRELS----WCKLTELYDD 113
A QK+L +L L+Y+DLYLIH+P G K P ++ N + + W + EL D+
Sbjct: 89 ACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDE 148
Query: 114 GKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSLYKFCKQHHITLQAY 171
G V A+G+SNF +E ++ + GL PAVNQ+E HPY TQ L ++C+ I + AY
Sbjct: 149 GLVKAIGISNFNHLQVEMIL-NKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAY 207
Query: 172 CSFGG-----TSCSNNSLLNDPVVVSTALKLEVTPAQV 204
G + SLL DP + + A K T AQV
Sbjct: 208 SPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQV 245
Score = 34.3 bits (75), Expect = 0.44
Identities = 16/37 (43%), Positives = 23/37 (62%), Gaps = 1/37 (2%)
Query: 13 VLNNGIMMPSIGLGTYRIRQSDIVMQVVDYALEAGYR 49
+LNNG MP +GLGT++ V + V A++ GYR
Sbjct: 3 LLNNGAKMPILGLGTWKSPPGQ-VTEAVKVAIDVGYR 38
>AL391427-2|CAI14727.1| 302|Homo sapiens aldo-keto reductase family
1, member C-like 1 protein.
Length = 302
Score = 86.6 bits (205), Expect = 8e-17
Identities = 66/200 (33%), Positives = 99/200 (49%), Gaps = 21/200 (10%)
Query: 63 AYQKSLENLDLEYVDLYLIHFPGGAKLPAEDKRNTKMRELSWCKLTELYDDGKVNAVGVS 122
A ++SL+ L +YVDL++IH P K P ++ + EL D ++ +
Sbjct: 101 ALERSLKKLGPDYVDLFIIHVPFAMKQPGKELLPKDASGEIILETVELCDTWELELI--- 157
Query: 123 NFTVAHLEGLMESNHGLVPAVNQV-EWHPYYTQSSLYKFCKQHHITLQAYCSFGGTSCSN 181
+ GL P NQV E HPY QS L +FCK I L AY + G
Sbjct: 158 ----LNKPGLRYK-----PTCNQVVECHPYLNQSKLLEFCKSKDIVLVAYSALGSQRDPQ 208
Query: 182 ------NSLLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKAVHPEHIKEN-RSLNF 234
LL +P++ S A K +P QV L + LQ+ V V+ K+ E IKEN + +F
Sbjct: 209 WVDPDCPHLLEEPILKSIAKKHSRSPGQVALRYQLQRGVVVLAKSFSQERIKENFQIFDF 268
Query: 235 KIPEEDMKALNQLSEKNVKY 254
++ EDMKA++ L+ +N++Y
Sbjct: 269 ELTPEDMKAIDGLN-RNLRY 287
>AL355303-1|CAI14201.1| 302|Homo sapiens aldo-keto reductase family
1, member C-like 1 protein.
Length = 302
Score = 86.6 bits (205), Expect = 8e-17
Identities = 66/200 (33%), Positives = 99/200 (49%), Gaps = 21/200 (10%)
Query: 63 AYQKSLENLDLEYVDLYLIHFPGGAKLPAEDKRNTKMRELSWCKLTELYDDGKVNAVGVS 122
A ++SL+ L +YVDL++IH P K P ++ + EL D ++ +
Sbjct: 101 ALERSLKKLGPDYVDLFIIHVPFAMKQPGKELLPKDASGEIILETVELCDTWELELI--- 157
Query: 123 NFTVAHLEGLMESNHGLVPAVNQV-EWHPYYTQSSLYKFCKQHHITLQAYCSFGGTSCSN 181
+ GL P NQV E HPY QS L +FCK I L AY + G
Sbjct: 158 ----LNKPGLRYK-----PTCNQVVECHPYLNQSKLLEFCKSKDIVLVAYSALGSQRDPQ 208
Query: 182 ------NSLLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKAVHPEHIKEN-RSLNF 234
LL +P++ S A K +P QV L + LQ+ V V+ K+ E IKEN + +F
Sbjct: 209 WVDPDCPHLLEEPILKSIAKKHSRSPGQVALRYQLQRGVVVLAKSFSQERIKENFQIFDF 268
Query: 235 KIPEEDMKALNQLSEKNVKY 254
++ EDMKA++ L+ +N++Y
Sbjct: 269 ELTPEDMKAIDGLN-RNLRY 287
>AB209017-1|BAD92254.1| 286|Homo sapiens aldo-keto reductase family
1, member C2 variant protein.
Length = 286
Score = 85.8 bits (203), Expect = 1e-16
Identities = 61/172 (35%), Positives = 88/172 (51%), Gaps = 20/172 (11%)
Query: 49 RMFAPSDHGSRAEQAYQKSLENLDLEYVDLYLIHFPGGAKLPAED----KRNTKMR---- 100
++++ S A ++SL+NL L+YVDLYLIHFP K P E+ N K+
Sbjct: 97 KLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVK-PGEEVIPKDENGKILFDTV 155
Query: 101 EL--SWCKLTELYDDGKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSS 156
+L +W + + D G ++GVSNF LE ++ + GL P NQVE HPY+ Q
Sbjct: 156 DLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMIL-NKPGLKYKPVCNQVECHPYFNQRK 214
Query: 157 LYKFCKQHHITLQAYCSFGG------TSCSNNSLLNDPVVVSTALKLEVTPA 202
L FCK I L AY + G ++ LL DPV+ + A K + P+
Sbjct: 215 LLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKAQANPS 266
>AK058142-1|BAB71682.1| 146|Homo sapiens protein ( Homo sapiens
cDNA FLJ25413 fis, clone TST03402, highly similar to
3-OXO-5-BETA-STEROID 4-DEHYDROGENASE (EC 1.3.99.6). ).
Length = 146
Score = 63.3 bits (147), Expect = 8e-10
Identities = 34/75 (45%), Positives = 43/75 (57%), Gaps = 3/75 (4%)
Query: 103 SWCKLTELYDDGKVNAVGVSNFTVAHLEGLMESNHGLV--PAVNQVEWHPYYTQSSLYKF 160
+W + D G V ++GVSNF LE L+ + GL P NQVE HPY+TQ L KF
Sbjct: 28 TWEAMEACKDAGLVKSLGVSNFNRRQLE-LILNKPGLKHKPVSNQVECHPYFTQPKLLKF 86
Query: 161 CKQHHITLQAYCSFG 175
C+QH I + AY G
Sbjct: 87 CQQHDIVITAYSPLG 101
>AF044961-1|AAC15671.1| 85|Homo sapiens aldose reductase-related
protein protein.
Length = 85
Score = 43.6 bits (98), Expect = 7e-04
Identities = 23/58 (39%), Positives = 37/58 (63%), Gaps = 1/58 (1%)
Query: 188 PVVVSTALKLEVTPAQVLLVWALQQDVAVIPKAVHPEHIKEN-RSLNFKIPEEDMKAL 244
P + A K + T AQVL+ + +Q++V VIPK+V P I EN + +FK+ +E+M +
Sbjct: 1 PKIKEIAAKHKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATI 58
>AB040822-1|BAC54567.1| 222|Homo sapiens aldo-keto reductase
related protein 3 protein.
Length = 222
Score = 41.1 bits (92), Expect = 0.004
Identities = 23/48 (47%), Positives = 29/48 (60%), Gaps = 1/48 (2%)
Query: 58 SRAEQAYQKSLENLDLEYVDLYLIHFPGGAKLPAEDKRNTKMRELSWC 105
S E A +KSL+ L L Y+DLYLIH+P G K P + ELS+C
Sbjct: 78 SLVETACRKSLKALKLNYLDLYLIHWPMGFK-PPHPEWIMSCSELSFC 124
Score = 39.1 bits (87), Expect = 0.015
Identities = 19/57 (33%), Positives = 38/57 (66%), Gaps = 2/57 (3%)
Query: 203 QVLLVWALQQDVAVIPKAVHPEHIKEN-RSLNFKIPEEDMKALNQLSEKNVKYAWDP 258
++L+ + +Q++V VIP ++ P HIKEN + +F++ + DM + L+ +N++ A P
Sbjct: 153 EILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLN-RNLRLAMFP 208
>AB040821-1|BAC54566.1| 263|Homo sapiens aldo-keto reductase
related protein 2 protein.
Length = 263
Score = 41.1 bits (92), Expect = 0.004
Identities = 23/48 (47%), Positives = 29/48 (60%), Gaps = 1/48 (2%)
Query: 58 SRAEQAYQKSLENLDLEYVDLYLIHFPGGAKLPAEDKRNTKMRELSWC 105
S E A +KSL+ L L Y+DLYLIH+P G K P + ELS+C
Sbjct: 78 SLVETACRKSLKALKLNYLDLYLIHWPMGFK-PPHPEWIMSCSELSFC 124
Score = 41.1 bits (92), Expect = 0.004
Identities = 25/76 (32%), Positives = 45/76 (59%), Gaps = 7/76 (9%)
Query: 184 LLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKAVHPEHIKEN-RSLNFKIPEEDMK 242
LLN P L+ + Q+L+ + +Q++V VIP ++ P HIKEN + +F++ + DM
Sbjct: 180 LLNKP-----GLRFKPLTNQILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMD 234
Query: 243 ALNQLSEKNVKYAWDP 258
+ L+ +N++ A P
Sbjct: 235 NILSLN-RNLRLAMFP 249
>AB040820-1|BAC54565.1| 250|Homo sapiens aldo-keto reductase
related protein 1 protein.
Length = 250
Score = 41.1 bits (92), Expect = 0.004
Identities = 23/48 (47%), Positives = 29/48 (60%), Gaps = 1/48 (2%)
Query: 58 SRAEQAYQKSLENLDLEYVDLYLIHFPGGAKLPAEDKRNTKMRELSWC 105
S E A +KSL+ L L Y+DLYLIH+P G K P + ELS+C
Sbjct: 78 SLVETACRKSLKALKLNYLDLYLIHWPMGFK-PPHPEWIMSCSELSFC 124
Score = 41.1 bits (92), Expect = 0.004
Identities = 25/76 (32%), Positives = 45/76 (59%), Gaps = 7/76 (9%)
Query: 184 LLNDPVVVSTALKLEVTPAQVLLVWALQQDVAVIPKAVHPEHIKEN-RSLNFKIPEEDMK 242
LLN P L+ + Q+L+ + +Q++V VIP ++ P HIKEN + +F++ + DM
Sbjct: 180 LLNKP-----GLRFKPLTNQILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMD 234
Query: 243 ALNQLSEKNVKYAWDP 258
+ L+ +N++ A P
Sbjct: 235 NILSLN-RNLRLAMFP 249
>AL355480-2|CAI22458.1| 147|Homo sapiens aldo-keto reductase family
1, member A1 (aldehydela) protein.
Length = 147
Score = 37.1 bits (82), Expect = 0.062
Identities = 15/36 (41%), Positives = 24/36 (66%)
Query: 49 RMFAPSDHGSRAEQAYQKSLENLDLEYVDLYLIHFP 84
+++ H E A +K+L +L LEY+DLYL+H+P
Sbjct: 80 KLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWP 115
Score = 32.7 bits (71), Expect = 1.3
Identities = 17/37 (45%), Positives = 21/37 (56%), Gaps = 1/37 (2%)
Query: 13 VLNNGIMMPSIGLGTYRIRQSDIVMQVVDYALEAGYR 49
+L+ G MP IGLGT++ V V YAL GYR
Sbjct: 7 LLHTGQKMPLIGLGTWKSEPGQ-VKAAVKYALSVGYR 42
>AF040639-1|AAD02195.1| 331|Homo sapiens aflatoxin B1-aldehyde
reductase protein.
Length = 331
Score = 35.5 bits (78), Expect = 0.19
Identities = 43/167 (25%), Positives = 71/167 (42%), Gaps = 17/167 (10%)
Query: 8 IPTTFVLNNGIMMPSIGLGTYRIRQSDIVMQVVDYALEAGYRMFAPSDHGSRAEQAYQKS 67
I T FV ++G +G R+ SD +++ A+ +F S + S
Sbjct: 43 IDTAFVYSDGQSETILGGLGLRLGGSDCRVKIDTKAIP----LFGNSLKPDSLRFQLETS 98
Query: 68 LENLDLEYVDLYLIHFPGGAKLPAEDKRNTKMRELSWCKLTELYDDGKVNAVGVSNFT-- 125
L+ L VDL+ +H P + P E+ L C +L+ +GK +G+SN+
Sbjct: 99 LKRLQCPRVDLFYLHMPDHS-TPVEE-------TLRACH--QLHQEGKFMELGLSNYAAW 148
Query: 126 -VAHLEGLMESNHGLVPAVNQVEWHPYYTQSSLYKFCKQHHITLQAY 171
VA + L +SN ++P V Q ++ Q F H L+ Y
Sbjct: 149 EVAEICTLCKSNGWILPTVYQGMYNAITRQVETELFPCLRHFGLRFY 195
>BC042420-1|AAH42420.2| 331|Homo sapiens aldo-keto reductase family
7, member A3 (aflatoxin aldehyde reductase) protein.
Length = 331
Score = 35.1 bits (77), Expect = 0.25
Identities = 43/167 (25%), Positives = 70/167 (41%), Gaps = 17/167 (10%)
Query: 8 IPTTFVLNNGIMMPSIGLGTYRIRQSDIVMQVVDYALEAGYRMFAPSDHGSRAEQAYQKS 67
I T FV + G +G R+ SD +++ A+ +F S + S
Sbjct: 43 IDTAFVYSEGQSETILGGLGLRLGGSDCRVKIDTKAIP----LFGNSLKPDSLRFQLETS 98
Query: 68 LENLDLEYVDLYLIHFPGGAKLPAEDKRNTKMRELSWCKLTELYDDGKVNAVGVSNFT-- 125
L+ L VDL+ +H P + P E+ L C +L+ +GK +G+SN+
Sbjct: 99 LKRLQCPRVDLFYLHMPDHS-TPVEE-------TLRACH--QLHQEGKFMELGLSNYAAW 148
Query: 126 -VAHLEGLMESNHGLVPAVNQVEWHPYYTQSSLYKFCKQHHITLQAY 171
VA + L +SN ++P V Q ++ Q F H L+ Y
Sbjct: 149 EVAEICTLCKSNGWILPTVYQGMYNAITRQVETELFPCLRHFGLRFY 195
>BC031562-1|AAH31562.1| 331|Homo sapiens aldo-keto reductase family
7, member A3 (aflatoxin aldehyde reductase) protein.
Length = 331
Score = 35.1 bits (77), Expect = 0.25
Identities = 43/167 (25%), Positives = 70/167 (41%), Gaps = 17/167 (10%)
Query: 8 IPTTFVLNNGIMMPSIGLGTYRIRQSDIVMQVVDYALEAGYRMFAPSDHGSRAEQAYQKS 67
I T FV + G +G R+ SD +++ A+ +F S + S
Sbjct: 43 IDTAFVYSEGQSETILGGLGLRLGGSDCRVKIDTKAIP----LFGNSLKPDSLRFQLETS 98
Query: 68 LENLDLEYVDLYLIHFPGGAKLPAEDKRNTKMRELSWCKLTELYDDGKVNAVGVSNFT-- 125
L+ L VDL+ +H P + P E+ L C +L+ +GK +G+SN+
Sbjct: 99 LKRLQCPRVDLFYLHMPDHS-TPVEE-------TLRACH--QLHQEGKFMELGLSNYAAW 148
Query: 126 -VAHLEGLMESNHGLVPAVNQVEWHPYYTQSSLYKFCKQHHITLQAY 171
VA + L +SN ++P V Q ++ Q F H L+ Y
Sbjct: 149 EVAEICTLCKSNGWILPTVYQGMYNAITRQVETELFPCLRHFGLRFY 195
>AJ271799-1|CAC81076.1| 331|Homo sapiens aflatoxin B1 aldehyde
reductase 2 protein.
Length = 331
Score = 35.1 bits (77), Expect = 0.25
Identities = 43/167 (25%), Positives = 70/167 (41%), Gaps = 17/167 (10%)
Query: 8 IPTTFVLNNGIMMPSIGLGTYRIRQSDIVMQVVDYALEAGYRMFAPSDHGSRAEQAYQKS 67
I T FV + G +G R+ SD +++ A+ +F S + S
Sbjct: 43 IDTAFVYSEGQSETILGGLGLRLGGSDCRVKIDTKAIP----LFGNSLKPDSLRFQLETS 98
Query: 68 LENLDLEYVDLYLIHFPGGAKLPAEDKRNTKMRELSWCKLTELYDDGKVNAVGVSNFT-- 125
L+ L VDL+ +H P + P E+ L C +L+ +GK +G+SN+
Sbjct: 99 LKRLQCPRVDLFYLHMPDHS-TPVEE-------TLRACH--QLHQEGKFMELGLSNYAAW 148
Query: 126 -VAHLEGLMESNHGLVPAVNQVEWHPYYTQSSLYKFCKQHHITLQAY 171
VA + L +SN ++P V Q ++ Q F H L+ Y
Sbjct: 149 EVAEICTLCKSNGWILPTVYQGMYNAITRQVETELFPCLRHFGLRFY 195
>BC025709-1|AAH25709.1| 331|Homo sapiens aldo-keto reductase family
7, member A3 (aflatoxin aldehyde reductase) protein.
Length = 331
Score = 34.7 bits (76), Expect = 0.33
Identities = 43/167 (25%), Positives = 70/167 (41%), Gaps = 17/167 (10%)
Query: 8 IPTTFVLNNGIMMPSIGLGTYRIRQSDIVMQVVDYALEAGYRMFAPSDHGSRAEQAYQKS 67
I T FV + G +G R+ SD +++ A+ +F S + S
Sbjct: 43 IDTAFVYSEGQSETILGGLGLRLGGSDCRVKIDTKAIP----LFGNSLKPDSLRFQLETS 98
Query: 68 LENLDLEYVDLYLIHFPGGAKLPAEDKRNTKMRELSWCKLTELYDDGKVNAVGVSNFT-- 125
L+ L VDL+ +H P + P E+ L C +L+ +GK +G+SN+
Sbjct: 99 LKRLQCPRVDLFYLHMPDHS-TPVEE-------TLRACH--QLHQEGKFVELGLSNYAAW 148
Query: 126 -VAHLEGLMESNHGLVPAVNQVEWHPYYTQSSLYKFCKQHHITLQAY 171
VA + L +SN ++P V Q ++ Q F H L+ Y
Sbjct: 149 EVAEICTLCKSNGWILPTVYQGMYNAITRQVETELFPCLRHFGLRFY 195
>AL035413-11|CAI22232.1| 331|Homo sapiens aldo-keto reductase
family 7, member A3 (aflatoxin aldehyde reductase)
protein.
Length = 331
Score = 34.7 bits (76), Expect = 0.33
Identities = 43/167 (25%), Positives = 70/167 (41%), Gaps = 17/167 (10%)
Query: 8 IPTTFVLNNGIMMPSIGLGTYRIRQSDIVMQVVDYALEAGYRMFAPSDHGSRAEQAYQKS 67
I T FV + G +G R+ SD +++ A+ +F S + S
Sbjct: 43 IDTAFVYSEGQSETILGGLGLRLGGSDCRVKIDTKAIP----LFGNSLKPDSLRFQLETS 98
Query: 68 LENLDLEYVDLYLIHFPGGAKLPAEDKRNTKMRELSWCKLTELYDDGKVNAVGVSNFT-- 125
L+ L VDL+ +H P + P E+ L C +L+ +GK +G+SN+
Sbjct: 99 LKRLQCPRVDLFYLHMPDHS-TPVEE-------TLRACH--QLHQEGKFVELGLSNYAAW 148
Query: 126 -VAHLEGLMESNHGLVPAVNQVEWHPYYTQSSLYKFCKQHHITLQAY 171
VA + L +SN ++P V Q ++ Q F H L+ Y
Sbjct: 149 EVAEICTLCKSNGWILPTVYQGMYNAITRQVETELFPCLRHFGLRFY 195
>AB037905-2|BAA92890.1| 45|Homo sapiens truncated aldo-keto
reductase protein.
Length = 45
Score = 32.3 bits (70), Expect = 1.8
Identities = 12/24 (50%), Positives = 17/24 (70%)
Query: 61 EQAYQKSLENLDLEYVDLYLIHFP 84
++ + SL+ L L Y+DLYL HFP
Sbjct: 12 QRGLEMSLKKLQLSYMDLYLFHFP 35
>AB037902-1|BAA92887.1| 130|Homo sapiens truncated aldo-keto
reductase protein.
Length = 130
Score = 32.3 bits (70), Expect = 1.8
Identities = 12/24 (50%), Positives = 17/24 (70%)
Query: 61 EQAYQKSLENLDLEYVDLYLIHFP 84
++ + SL+ L L Y+DLYL HFP
Sbjct: 97 QRGLEMSLKKLQLSYMDLYLFHFP 120
>Y16675-1|CAA76347.1| 330|Homo sapiens aflatoxin B1-aldehyde
reductase protein.
Length = 330
Score = 31.9 bits (69), Expect = 2.3
Identities = 31/110 (28%), Positives = 49/110 (44%), Gaps = 13/110 (11%)
Query: 65 QKSLENLDLEYVDLYLIHFPGGAKLPAEDKRNTKMRELSWCKLTELYDDGKVNAVGVSNF 124
+ SL+ L VDL+ +H P P E+ L C+ L+ +GK +G+SN+
Sbjct: 95 ETSLKRLQCPQVDLFYLHAPDHG-TPVEE-------TLHACQ--RLHQEGKFVELGLSNY 144
Query: 125 T---VAHLEGLMESNHGLVPAVNQVEWHPYYTQSSLYKFCKQHHITLQAY 171
VA + L +SN ++P V Q ++ Q F H L+ Y
Sbjct: 145 ASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFY 194
>BT007347-1|AAP36011.1| 330|Homo sapiens aldo-keto reductase family
7, member A2 (aflatoxin aldehyde reductase) protein.
Length = 330
Score = 31.9 bits (69), Expect = 2.3
Identities = 31/110 (28%), Positives = 49/110 (44%), Gaps = 13/110 (11%)
Query: 65 QKSLENLDLEYVDLYLIHFPGGAKLPAEDKRNTKMRELSWCKLTELYDDGKVNAVGVSNF 124
+ SL+ L VDL+ +H P P E+ L C+ L+ +GK +G+SN+
Sbjct: 95 ETSLKRLQCPQVDLFYLHAPDHG-TPVEE-------TLHACQ--RLHQEGKFVELGLSNY 144
Query: 125 T---VAHLEGLMESNHGLVPAVNQVEWHPYYTQSSLYKFCKQHHITLQAY 171
VA + L +SN ++P V Q ++ Q F H L+ Y
Sbjct: 145 ASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFY 194
>BC013996-1|AAH13996.1| 330|Homo sapiens AKR7A2 protein protein.
Length = 330
Score = 31.9 bits (69), Expect = 2.3
Identities = 31/110 (28%), Positives = 49/110 (44%), Gaps = 13/110 (11%)
Query: 65 QKSLENLDLEYVDLYLIHFPGGAKLPAEDKRNTKMRELSWCKLTELYDDGKVNAVGVSNF 124
+ SL+ L VDL+ +H P P E+ L C+ L+ +GK +G+SN+
Sbjct: 95 ETSLKRLQCPQVDLFYLHAPDHG-TPVEE-------TLHACQ--RLHQEGKFVELGLSNY 144
Query: 125 T---VAHLEGLMESNHGLVPAVNQVEWHPYYTQSSLYKFCKQHHITLQAY 171
VA + L +SN ++P V Q ++ Q F H L+ Y
Sbjct: 145 ASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFY 194
>BC012171-1|AAH12171.1| 330|Homo sapiens AKR7A2 protein protein.
Length = 330
Score = 31.9 bits (69), Expect = 2.3
Identities = 31/110 (28%), Positives = 49/110 (44%), Gaps = 13/110 (11%)
Query: 65 QKSLENLDLEYVDLYLIHFPGGAKLPAEDKRNTKMRELSWCKLTELYDDGKVNAVGVSNF 124
+ SL+ L VDL+ +H P P E+ L C+ L+ +GK +G+SN+
Sbjct: 95 ETSLKRLQCPQVDLFYLHAPDHG-TPVEE-------TLHACQ--RLHQEGKFVELGLSNY 144
Query: 125 T---VAHLEGLMESNHGLVPAVNQVEWHPYYTQSSLYKFCKQHHITLQAY 171
VA + L +SN ++P V Q ++ Q F H L+ Y
Sbjct: 145 ASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFY 194
>BC011586-1|AAH11586.1| 330|Homo sapiens AKR7A2 protein protein.
Length = 330
Score = 31.9 bits (69), Expect = 2.3
Identities = 31/110 (28%), Positives = 49/110 (44%), Gaps = 13/110 (11%)
Query: 65 QKSLENLDLEYVDLYLIHFPGGAKLPAEDKRNTKMRELSWCKLTELYDDGKVNAVGVSNF 124
+ SL+ L VDL+ +H P P E+ L C+ L+ +GK +G+SN+
Sbjct: 95 ETSLKRLQCPQVDLFYLHAPDHG-TPVEE-------TLHACQ--RLHQEGKFVELGLSNY 144
Query: 125 T---VAHLEGLMESNHGLVPAVNQVEWHPYYTQSSLYKFCKQHHITLQAY 171
VA + L +SN ++P V Q ++ Q F H L+ Y
Sbjct: 145 ASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFY 194
>BC010852-1|AAH10852.1| 330|Homo sapiens AKR7A2 protein protein.
Length = 330
Score = 31.9 bits (69), Expect = 2.3
Identities = 31/110 (28%), Positives = 49/110 (44%), Gaps = 13/110 (11%)
Query: 65 QKSLENLDLEYVDLYLIHFPGGAKLPAEDKRNTKMRELSWCKLTELYDDGKVNAVGVSNF 124
+ SL+ L VDL+ +H P P E+ L C+ L+ +GK +G+SN+
Sbjct: 95 ETSLKRLQCPQVDLFYLHAPDHG-TPVEE-------TLHACQ--RLHQEGKFVELGLSNY 144
Query: 125 T---VAHLEGLMESNHGLVPAVNQVEWHPYYTQSSLYKFCKQHHITLQAY 171
VA + L +SN ++P V Q ++ Q F H L+ Y
Sbjct: 145 ASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFY 194
>BC007352-1|AAH07352.2| 358|Homo sapiens AKR7A2 protein protein.
Length = 358
Score = 31.9 bits (69), Expect = 2.3
Identities = 31/110 (28%), Positives = 49/110 (44%), Gaps = 13/110 (11%)
Query: 65 QKSLENLDLEYVDLYLIHFPGGAKLPAEDKRNTKMRELSWCKLTELYDDGKVNAVGVSNF 124
+ SL+ L VDL+ +H P P E+ L C+ L+ +GK +G+SN+
Sbjct: 123 ETSLKRLQCPQVDLFYLHAPDHG-TPVEE-------TLHACQ--RLHQEGKFVELGLSNY 172
Query: 125 T---VAHLEGLMESNHGLVPAVNQVEWHPYYTQSSLYKFCKQHHITLQAY 171
VA + L +SN ++P V Q ++ Q F H L+ Y
Sbjct: 173 ASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFY 222
>BC004111-1|AAH04111.3| 330|Homo sapiens AKR7A2 protein protein.
Length = 330
Score = 31.9 bits (69), Expect = 2.3
Identities = 31/110 (28%), Positives = 49/110 (44%), Gaps = 13/110 (11%)
Query: 65 QKSLENLDLEYVDLYLIHFPGGAKLPAEDKRNTKMRELSWCKLTELYDDGKVNAVGVSNF 124
+ SL+ L VDL+ +H P P E+ L C+ L+ +GK +G+SN+
Sbjct: 95 ETSLKRLQCPQVDLFYLHAPDHG-TPVEE-------TLHACQ--RLHQEGKFVELGLSNY 144
Query: 125 T---VAHLEGLMESNHGLVPAVNQVEWHPYYTQSSLYKFCKQHHITLQAY 171
VA + L +SN ++P V Q ++ Q F H L+ Y
Sbjct: 145 ASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFY 194
>AL035413-8|CAB72321.1| 330|Homo sapiens aldo-keto reductase family
7, member A2 (aflatoxin aldehyde reductase) protein.
Length = 330
Score = 31.9 bits (69), Expect = 2.3
Identities = 31/110 (28%), Positives = 49/110 (44%), Gaps = 13/110 (11%)
Query: 65 QKSLENLDLEYVDLYLIHFPGGAKLPAEDKRNTKMRELSWCKLTELYDDGKVNAVGVSNF 124
+ SL+ L VDL+ +H P P E+ L C+ L+ +GK +G+SN+
Sbjct: 95 ETSLKRLQCPQVDLFYLHAPDHG-TPVEE-------TLHACQ--RLHQEGKFVELGLSNY 144
Query: 125 T---VAHLEGLMESNHGLVPAVNQVEWHPYYTQSSLYKFCKQHHITLQAY 171
VA + L +SN ++P V Q ++ Q F H L+ Y
Sbjct: 145 ASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFY 194
>AJ278012-1|CAC79668.1| 259|Homo sapiens aflatoxin B1 aldehyde
reductase 3 protein.
Length = 259
Score = 31.9 bits (69), Expect = 2.3
Identities = 31/110 (28%), Positives = 49/110 (44%), Gaps = 13/110 (11%)
Query: 65 QKSLENLDLEYVDLYLIHFPGGAKLPAEDKRNTKMRELSWCKLTELYDDGKVNAVGVSNF 124
+ SL+ L VDL+ +H P + P E+ L C +L+ +GK +G+SN+
Sbjct: 24 ETSLKRLQCPUVDLFYLHAPDHS-APVEE-------TLRACH--QLHQEGKFVELGLSNY 73
Query: 125 T---VAHLEGLMESNHGLVPAVNQVEWHPYYTQSSLYKFCKQHHITLQAY 171
VA + L +SN ++P V Q + Q F H L+ Y
Sbjct: 74 AAWEVAEICTLCKSNGWILPTVYQGMYSATTRQVETELFPYLRHFGLRFY 123
>AF026947-1|AAC52104.1| 330|Homo sapiens aflatoxin aldehyde
reductase AFAR protein.
Length = 330
Score = 31.9 bits (69), Expect = 2.3
Identities = 31/110 (28%), Positives = 49/110 (44%), Gaps = 13/110 (11%)
Query: 65 QKSLENLDLEYVDLYLIHFPGGAKLPAEDKRNTKMRELSWCKLTELYDDGKVNAVGVSNF 124
+ SL+ L VDL+ +H P P E+ L C+ L+ +GK +G+SN+
Sbjct: 95 ETSLKRLQCPQVDLFYLHTPDHG-TPVEE-------TLHACQ--RLHQEGKFVELGLSNY 144
Query: 125 T---VAHLEGLMESNHGLVPAVNQVEWHPYYTQSSLYKFCKQHHITLQAY 171
VA + L +SN ++P V Q ++ Q F H L+ Y
Sbjct: 145 ASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFY 194
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.317 0.133 0.396
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 39,514,800
Number of Sequences: 224733
Number of extensions: 1565167
Number of successful extensions: 6349
Number of sequences better than 10.0: 107
Number of HSP's better than 10.0 without gapping: 90
Number of HSP's successfully gapped in prelim test: 17
Number of HSP's that attempted gapping in prelim test: 5937
Number of HSP's gapped (non-prelim): 190
length of query: 262
length of database: 73,234,838
effective HSP length: 89
effective length of query: 173
effective length of database: 53,233,601
effective search space: 9209412973
effective search space used: 9209412973
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
S2: 64 (29.9 bits)
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