Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA000672-TA|BGIBMGA000672-PA|IPR002020|Citrate synthase,
IPR010109|Citrate synthase, eukaryotic
(465 letters)
Database: uniref50
1,657,284 sequences; 575,637,011 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef50_O75390 Cluster: Citrate synthase, mitochondrial precurs... 738 0.0
UniRef50_P20115 Cluster: Citrate synthase 4, mitochondrial precu... 619 e-176
UniRef50_Q9M1D3 Cluster: Citrate synthase 5, mitochondrial precu... 613 e-174
UniRef50_Q95TZ4 Cluster: Citrate synthase; n=1; Drosophila melan... 515 e-144
UniRef50_Q4QDX3 Cluster: Probable citrate synthase, mitochondria... 511 e-143
UniRef50_A0DZ50 Cluster: Citrate synthase; n=6; Paramecium tetra... 510 e-143
UniRef50_A6S819 Cluster: Citrate synthase; n=1; Botryotinia fuck... 500 e-140
UniRef50_Q6JGH9 Cluster: Citrate synthase; n=17; Desulfuromonada... 452 e-126
UniRef50_P43635 Cluster: Citrate synthase 3; n=7; Saccharomyceta... 423 e-117
UniRef50_UPI00006CBE2B Cluster: citrate synthase; n=1; Tetrahyme... 420 e-116
UniRef50_A4ZVV6 Cluster: Mitochondrial citrate synthase 1; n=1; ... 416 e-115
UniRef50_Q4N4H4 Cluster: Citrate synthase, putative; n=3; Piropl... 396 e-109
UniRef50_A5KE63 Cluster: Citrate synthase, mitochondrial, putati... 382 e-104
UniRef50_UPI00006CFBEC Cluster: Citrate synthase family protein;... 339 8e-92
UniRef50_UPI00015B4F54 Cluster: PREDICTED: hypothetical protein;... 256 1e-66
UniRef50_UPI0000DB6B6F Cluster: PREDICTED: similar to citrate sy... 226 8e-58
UniRef50_Q6MAA4 Cluster: Putative citrate (Si)-synthase; n=1; Ca... 192 2e-47
UniRef50_P42457 Cluster: Citrate synthase; n=10; Actinobacterida... 125 2e-27
UniRef50_Q59977 Cluster: Citrate synthase; n=37; Bacteria|Rep: C... 124 4e-27
UniRef50_Q8ZWP2 Cluster: Citrate synthase; n=7; Thermoproteaceae... 124 5e-27
UniRef50_Q4FLH9 Cluster: Citrate (Si)-synthase; n=3; Bacteria|Re... 122 2e-26
UniRef50_Q9LXS6 Cluster: Citrate synthase 2, peroxisomal precurs... 115 3e-24
UniRef50_Q2JTT9 Cluster: 2-methylcitrate synthase/citrate syntha... 113 9e-24
UniRef50_Q550V8 Cluster: Citrate synthase; n=3; Dictyostelium di... 113 9e-24
UniRef50_Q7NZ52 Cluster: Citrate (Si)-synthase; n=4; Bacteria|Re... 111 3e-23
UniRef50_A6ERK5 Cluster: Citrate synthase; n=1; unidentified eub... 111 4e-23
UniRef50_Q9RWB2 Cluster: Citrate synthase; n=7; Deinococci|Rep: ... 111 5e-23
UniRef50_Q53554 Cluster: Citrate synthase; n=3; Archaea|Rep: Cit... 109 1e-22
UniRef50_Q10530 Cluster: Citrate synthase 1; n=288; cellular org... 109 1e-22
UniRef50_Q9WYC6 Cluster: Citrate synthase; n=2; Thermotoga|Rep: ... 107 6e-22
UniRef50_UPI000023D08B Cluster: hypothetical protein FG02352.1; ... 107 8e-22
UniRef50_Q1FP94 Cluster: Citrate (Si)-synthase; n=4; Clostridial... 106 1e-21
UniRef50_Q18RG7 Cluster: Citrate synthase; n=9; Bacteria|Rep: Ci... 101 4e-20
UniRef50_O28929 Cluster: Citrate synthase; n=2; cellular organis... 101 4e-20
UniRef50_P51034 Cluster: Citrate synthase; n=351; Bacteria|Rep: ... 100 2e-19
UniRef50_P09948 Cluster: Citrate synthase; n=335; cellular organ... 99 2e-19
UniRef50_A0RVR8 Cluster: Citrate synthase; n=4; cellular organis... 98 4e-19
UniRef50_A1WHQ6 Cluster: Citrate synthase I; n=8; Proteobacteria... 98 5e-19
UniRef50_Q59939 Cluster: Citrate synthase; n=15; Bacilli|Rep: Ci... 95 4e-18
UniRef50_Q93FW0 Cluster: Citrate synthase; n=4; Neorickettsia|Re... 95 5e-18
UniRef50_P56062 Cluster: Citrate synthase; n=43; Epsilonproteoba... 94 6e-18
UniRef50_Q9LXS7 Cluster: Citrate synthase 1, peroxisomal precurs... 94 8e-18
UniRef50_A4EA98 Cluster: Putative uncharacterized protein; n=1; ... 92 2e-17
UniRef50_Q9YB84 Cluster: Citrate synthase; n=1; Aeropyrum pernix... 92 2e-17
UniRef50_Q0LNQ6 Cluster: Citrate (Si)-synthase; n=1; Herpetosiph... 91 6e-17
UniRef50_A6CE34 Cluster: Citrate synthase; n=1; Planctomyces mar... 90 1e-16
UniRef50_Q8TU25 Cluster: Citrate (Si)-synthase; n=3; Methanosarc... 89 3e-16
UniRef50_A0LVH0 Cluster: 2-methylcitrate synthase/citrate syntha... 88 5e-16
UniRef50_P39120 Cluster: Citrate synthase 2; n=9; cellular organ... 87 9e-16
UniRef50_Q56063 Cluster: 2-methylcitrate synthase; n=14; Enterob... 87 1e-15
UniRef50_Q6MQB4 Cluster: CitZ protein; n=1; Bdellovibrio bacteri... 86 2e-15
UniRef50_Q93FW6 Cluster: Citrate synthase; n=105; Proteobacteria... 86 2e-15
UniRef50_Q0RN64 Cluster: Citrate synthase; n=3; Actinomycetales|... 85 4e-15
UniRef50_Q3ISY7 Cluster: Citrate (Si)-synthase; n=1; Natronomona... 85 4e-15
UniRef50_Q1IPC3 Cluster: 2-methylcitrate synthase/citrate syntha... 84 7e-15
UniRef50_P45858 Cluster: Citrate synthase 3; n=19; Bacillaceae|R... 83 2e-14
UniRef50_Q9XBT3 Cluster: PrpC; n=12; cellular organisms|Rep: Prp... 82 3e-14
UniRef50_P39119 Cluster: Citrate synthase 1; n=7; Bacillus|Rep: ... 81 5e-14
UniRef50_UPI0000D9A0A8 Cluster: PREDICTED: similar to citrate sy... 81 6e-14
UniRef50_Q8NSL1 Cluster: 2-methylcitrate synthase 2; n=29; Bacte... 81 8e-14
UniRef50_Q7N2E3 Cluster: Similar to citrate synthase; n=1; Photo... 80 1e-13
UniRef50_A6T3T1 Cluster: 2-methylcitrate synthase; n=60; Bacteri... 79 2e-13
UniRef50_Q8ZSU1 Cluster: Citrate synthase part 1, authentic fram... 79 2e-13
UniRef50_Q7W5Q6 Cluster: 2-methylcitrate synthase; n=122; Bacter... 79 2e-13
UniRef50_Q8A616 Cluster: Citrate synthase; n=16; Bacteria|Rep: C... 79 3e-13
UniRef50_P21553 Cluster: Citrate synthase; n=9; Archaea|Rep: Cit... 75 5e-12
UniRef50_Q8F887 Cluster: Citrate synthase; n=4; Leptospira|Rep: ... 73 1e-11
UniRef50_Q6L2P8 Cluster: 2-methylcitrate-synthase; n=1; Picrophi... 73 2e-11
UniRef50_A6T5R8 Cluster: Putative citrate synthase; n=1; Klebsie... 72 3e-11
UniRef50_A7C184 Cluster: Citrate synthase; n=1; Beggiatoa sp. PS... 72 4e-11
UniRef50_Q2R108 Cluster: Putative uncharacterized protein; n=1; ... 72 4e-11
UniRef50_Q6CZN0 Cluster: Citrate synthase; n=14; Proteobacteria|... 71 9e-11
UniRef50_UPI000038E288 Cluster: hypothetical protein Faci_030001... 69 3e-10
UniRef50_A4YKX3 Cluster: Putative citrate synthase; n=1; Bradyrh... 69 3e-10
UniRef50_Q89XX2 Cluster: Citrate synthase; n=8; Alphaproteobacte... 69 3e-10
UniRef50_Q1AT04 Cluster: Citrate (Si)-synthase; n=4; Bacteria|Re... 69 3e-10
UniRef50_Q1AT05 Cluster: Citrate synthase; n=1; Rubrobacter xyla... 68 5e-10
UniRef50_A0LIG9 Cluster: Citrate (Si)-synthase; n=1; Syntrophoba... 65 4e-09
UniRef50_A0NXG1 Cluster: Citrate synthase; n=1; Stappia aggregat... 64 8e-09
UniRef50_P63778 Cluster: Putative citrate synthase 2; n=34; Acti... 64 8e-09
UniRef50_A4KFK1 Cluster: Citrate synthase I gltA2; n=1; Mycobact... 63 2e-08
UniRef50_A6C1S1 Cluster: Type II citrate synthase; n=1; Planctom... 62 2e-08
UniRef50_A2QSJ2 Cluster: Citrate synthase; n=2; Aspergillus|Rep:... 62 4e-08
UniRef50_A0NXG0 Cluster: Type II citrate synthase; n=2; Alphapro... 61 5e-08
UniRef50_A6X0R5 Cluster: Citrate (Si)-synthase; n=1; Ochrobactru... 60 2e-07
UniRef50_Q08XU9 Cluster: Citrate synthase; n=2; Cystobacterineae... 58 5e-07
UniRef50_A2QA25 Cluster: Citrate synthase; n=1; Aspergillus nige... 58 5e-07
UniRef50_Q5AVT7 Cluster: Citrate synthase; n=7; Trichocomaceae|R... 57 9e-07
UniRef50_Q98FC3 Cluster: Citrate synthase; CitZ; n=1; Mesorhizob... 56 3e-06
UniRef50_Q0RN63 Cluster: Putative citrate synthase-like protein;... 54 1e-05
UniRef50_A7HRE6 Cluster: Citrate synthase; n=1; Parvibaculum lav... 51 7e-05
UniRef50_Q0LLM4 Cluster: Citrate synthase; n=1; Herpetosiphon au... 50 1e-04
UniRef50_Q1IW45 Cluster: Citrate synthase; n=1; Deinococcus geot... 48 7e-04
UniRef50_Q397U9 Cluster: Citrate synthase; n=4; Burkholderiales|... 46 0.002
UniRef50_Q11FP9 Cluster: Citrate synthase; n=6; Alphaproteobacte... 46 0.002
UniRef50_A7E4M0 Cluster: Putative uncharacterized protein; n=1; ... 45 0.004
UniRef50_Q8RV72 Cluster: Putative citrate synthetase; n=1; Arabi... 44 0.009
UniRef50_Q0BWL7 Cluster: Citrate synthase family protein; n=1; H... 44 0.011
UniRef50_Q89XX3 Cluster: Citrate synthase; n=3; Bradyrhizobium|R... 42 0.026
UniRef50_A0AX29 Cluster: Citrate synthase; n=7; Burkholderiales|... 42 0.035
UniRef50_Q62HJ8 Cluster: Citrate synthase family protein; n=19; ... 42 0.046
UniRef50_Q4STI8 Cluster: Chromosome undetermined SCAF14198, whol... 40 0.18
UniRef50_Q13UT6 Cluster: Bifunctional--transcriptional regulator... 40 0.18
UniRef50_Q98FC2 Cluster: Citrate synthase II; n=3; Alphaproteoba... 39 0.24
UniRef50_Q2NGE5 Cluster: Putative uncharacterized protein; n=1; ... 39 0.32
UniRef50_P53396 Cluster: ATP-citrate synthase (EC 2.3.3.8) (ATP-... 38 0.56
UniRef50_A1RWT4 Cluster: Roadblock/LC7 family protein; n=1; Ther... 37 0.99
UniRef50_Q19T76 Cluster: GltA; n=1; Anaplasma phagocytophilum|Re... 37 1.3
UniRef50_Q0LSA0 Cluster: Excisionase/Xis, DNA-binding; n=1; Caul... 36 1.7
UniRef50_Q2K872 Cluster: Citrate synthase protein; n=3; Rhizobia... 36 3.0
UniRef50_Q84I41 Cluster: Citrate synthase; n=306; cellular organ... 35 4.0
UniRef50_O70007 Cluster: Putative citrate synthase-like protein;... 35 5.3
UniRef50_A6GI60 Cluster: Putative uncharacterized protein; n=1; ... 35 5.3
UniRef50_A3YDA3 Cluster: Putative C4-dicarboxylate-binding perip... 35 5.3
UniRef50_A2DBQ4 Cluster: Putative uncharacterized protein; n=1; ... 35 5.3
UniRef50_A3I449 Cluster: Thioredoxin; n=1; Bacillus sp. B14905|R... 34 6.9
UniRef50_Q9XFY7 Cluster: Putative ATP-dependent citrate lyase; n... 34 6.9
UniRef50_Q6BIP6 Cluster: Debaryomyces hansenii chromosome G of s... 34 6.9
UniRef50_Q2PPA5 Cluster: Geranylgeranyl diphosphate synthase; n=... 34 6.9
UniRef50_Q6MBV1 Cluster: Putative uncharacterized protein; n=1; ... 34 9.2
UniRef50_Q46UF9 Cluster: Citrate synthase; n=5; Cupriavidus|Rep:... 34 9.2
UniRef50_Q3HKI3 Cluster: Possible virC1; n=2; Rhodobacter sphaer... 34 9.2
UniRef50_A4IPQ3 Cluster: Citrate synthase I; n=1; Geobacillus th... 34 9.2
UniRef50_A0UVE9 Cluster: Xylulokinase; n=1; Clostridium cellulol... 34 9.2
UniRef50_A2EPG1 Cluster: Viral A-type inclusion protein, putativ... 34 9.2
UniRef50_A2DLI0 Cluster: Putative uncharacterized protein; n=1; ... 34 9.2
>UniRef50_O75390 Cluster: Citrate synthase, mitochondrial precursor;
n=140; cellular organisms|Rep: Citrate synthase,
mitochondrial precursor - Homo sapiens (Human)
Length = 466
Score = 738 bits (1824), Expect = 0.0
Identities = 342/463 (73%), Positives = 393/463 (84%), Gaps = 2/463 (0%)
Query: 1 MALFRITSSRLVELQKACPTATVLLRGLSAEQTNLKSILQEKIPKEQEKIREFRKKHGST 60
MAL + L +C + R SA TNLK IL + IPKEQ +I+ FR++HG T
Sbjct: 1 MALLTAAARLLGTKNASC--LVLAARHASASSTNLKDILADLIPKEQARIKTFRQQHGKT 58
Query: 61 KVGEVTVDMMYGGMRGIKGLVWETSVLDADEGIRFRGLSIPECQQQLPKAKGGEEPLPEG 120
VG++TVDMMYGGMRG+KGLV+ETSVLD DEGIRFRG SIPECQ+ LPKAKGGEEPLPEG
Sbjct: 59 VVGQITVDMMYGGMRGMKGLVYETSVLDPDEGIRFRGFSIPECQKLLPKAKGGEEPLPEG 118
Query: 121 LFWLLVTGDIPTEAQAKALSKEWAARAELPAHVVTMLNNMPGKLHPMSQFSAAVTALNSE 180
LFWLLVTG IPTE Q LSKEWA RA LP+HVVTML+N P LHPMSQ SAAVTALNSE
Sbjct: 119 LFWLLVTGHIPTEEQVSWLSKEWAKRAALPSHVVTMLDNFPTNLHPMSQLSAAVTALNSE 178
Query: 181 SKFAKAYSEGVHKSKYWEYVYEDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDWSA 240
S FA+AY++G+ ++KYWE +YED+M+LIAKLP +AA IYRN+YR+G GIGAID N DWS
Sbjct: 179 SNFARAYAQGISRTKYWELIYEDSMDLIAKLPCVAAKIYRNLYREGSGIGAIDSNLDWSH 238
Query: 241 NYCNMLGFDDPQFTELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAG 300
N+ NMLG+ D QFTEL RLYLTIHSDHEGGNVSAHT+HLVGSALSDPYLSFAA +NGLAG
Sbjct: 239 NFTNMLGYTDHQFTELTRLYLTIHSDHEGGNVSAHTSHLVGSALSDPYLSFAAAMNGLAG 298
Query: 301 PLHGLANQEVLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPRYT 360
PLHGLANQEVLVWL +L+K+VG + ++E+L+++IW TL SG+VVPGYGHAVLRKTDPRYT
Sbjct: 299 PLHGLANQEVLVWLTQLQKEVGKDVSDEKLRDYIWNTLNSGRVVPGYGHAVLRKTDPRYT 358
Query: 361 CQREFALKHLPNDPLFKLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYGLKEMN 420
CQREFALKHLPNDP+FKLVA +YK+VP +L E GK KNPWPNVD+HSGVLLQYYG+ EMN
Sbjct: 359 CQREFALKHLPNDPMFKLVAQLYKIVPNVLLEQGKAKNPWPNVDAHSGVLLQYYGMTEMN 418
Query: 421 YYTVMFGVSRALGVLAQLIWSRALGLPIERPKSLSTEMLMKQV 463
YYTV+FGVSRALGVLAQLIWSRALG P+ERPKS+STE LMK V
Sbjct: 419 YYTVLFGVSRALGVLAQLIWSRALGFPLERPKSMSTEGLMKFV 461
>UniRef50_P20115 Cluster: Citrate synthase 4, mitochondrial
precursor; n=27; Eukaryota|Rep: Citrate synthase 4,
mitochondrial precursor - Arabidopsis thaliana
(Mouse-ear cress)
Length = 474
Score = 619 bits (1529), Expect = e-176
Identities = 276/459 (60%), Positives = 367/459 (79%), Gaps = 1/459 (0%)
Query: 1 MALFRITSSRLVELQKACPTATVLLRGLSAEQTNLKSILQEKIPKEQEKIREFRKKHGST 60
++ F SR+ Q + + ++ S+ +LKS LQE IP++Q+++++ + +HG
Sbjct: 7 VSAFTRLRSRVQGQQSSLSNSVRWIQMQSSTDLDLKSQLQELIPEQQDRLKKLKSEHGKV 66
Query: 61 KVGEVTVDMMYGGMRGIKGLVWETSVLDADEGIRFRGLSIPECQQQLPKAKGGEEPLPEG 120
++G +TVDM+ GGMRG+ GL+WETS+LD +EGIRFRGLSIPECQ+ LP A+ G EPLPEG
Sbjct: 67 QLGNITVDMVIGGMRGMTGLLWETSLLDPEEGIRFRGLSIPECQKVLPTAQSGAEPLPEG 126
Query: 121 LFWLLVTGDIPTEAQAKALSKEWAARAELPAHVVTMLNNMPGKLHPMSQFSAAVTALNSE 180
L WLL+TG +P++ Q +ALSK+ A RA +P +V ++ +P HPM+QF++ V AL +
Sbjct: 127 LLWLLLTGKVPSKEQVEALSKDLANRAAVPDYVYNAIDALPSTAHPMTQFASGVMALQVQ 186
Query: 181 SKFAKAYSEGVHKSKYWEYVYEDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDWSA 240
S+F KAY G+HKSK+WE YED +NLIA++PV+AA +YR +Y++G I + D + D+ A
Sbjct: 187 SEFQKAYENGIHKSKFWEPTYEDCLNLIARVPVVAAYVYRRMYKNGDSIPS-DKSLDYGA 245
Query: 241 NYCNMLGFDDPQFTELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAG 300
N+ +MLGFDD + ELMRLY+TIHSDHEGGNVSAHT HLVGSALSDPYLSFAA LNGLAG
Sbjct: 246 NFSHMLGFDDEKVKELMRLYITIHSDHEGGNVSAHTGHLVGSALSDPYLSFAAALNGLAG 305
Query: 301 PLHGLANQEVLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPRYT 360
PLHGLANQEVL+W++ + ++ G++ ++EQLKE++WKTL SG+V+PGYGH VLR TDPRY
Sbjct: 306 PLHGLANQEVLLWIKSVVEECGEDISKEQLKEYVWKTLNSGKVIPGYGHGVLRNTDPRYV 365
Query: 361 CQREFALKHLPNDPLFKLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYGLKEMN 420
CQREFALKHLP+DPLF+LV+ +Y+VVPP+LTELGKVKNPWPNVD+HSGVLL +YGL E
Sbjct: 366 CQREFALKHLPDDPLFQLVSKLYEVVPPVLTELGKVKNPWPNVDAHSGVLLNHYGLTEAR 425
Query: 421 YYTVMFGVSRALGVLAQLIWSRALGLPIERPKSLSTEML 459
YYTV+FGVSR+LG+ +QLIW RALGL +ERPKS++ + L
Sbjct: 426 YYTVLFGVSRSLGICSQLIWDRALGLALERPKSVTMDWL 464
>UniRef50_Q9M1D3 Cluster: Citrate synthase 5, mitochondrial
precursor; n=26; Eukaryota|Rep: Citrate synthase 5,
mitochondrial precursor - Arabidopsis thaliana
(Mouse-ear cress)
Length = 433
Score = 613 bits (1513), Expect = e-174
Identities = 277/427 (64%), Positives = 353/427 (82%), Gaps = 7/427 (1%)
Query: 34 NLKSILQEKIPKEQEKIREFRKKHGSTKVGEVTVDMMYGGMRGIKGLVWETSVLDADEGI 93
+LKS +QE IP++Q+++++ + + G VG +TVDM+ GGMRG+ GL+WETS+LDADEGI
Sbjct: 5 DLKSQMQEIIPEQQDRLKKLKSEQGKVPVGNITVDMVLGGMRGMTGLLWETSLLDADEGI 64
Query: 94 RFRGLSIPECQQQLPKAKGGEEPLPEGLFWLLVTGDIPTEAQAKALSKEWAARAELPAHV 153
RFRG+SIPECQ+ LP A+ GEEPLPE L WLL+TG +PT+ QA ALS E A RA +PA
Sbjct: 65 RFRGMSIPECQKILPSAESGEEPLPESLLWLLLTGKVPTKEQANALSTELAHRAAVPA-- 122
Query: 154 VTMLNNMPGKLHPMSQFSAAVTALNSESKFAKAYSEG-VHKSKYWEYVYEDTMNLIAKLP 212
++ +P HPM+QF++ V AL +S+F KAY +G + KSKYWE +ED +NLIA++P
Sbjct: 123 ---IDALPSTAHPMTQFASGVMALQVQSEFQKAYEQGDISKSKYWEPTFEDALNLIARVP 179
Query: 213 VIAATIYRNVYRDGKGIGAIDDNKDWSANYCNMLGFDDPQFTELMRLYLTIHSDHEGGNV 272
V+A+ +YR +Y+DG I +DD+ D+ AN+ +MLGFD PQ ELMRLY+TIHSDHEGGNV
Sbjct: 180 VVASYVYRRMYKDGSII-PLDDSLDYGANFSHMLGFDSPQMKELMRLYVTIHSDHEGGNV 238
Query: 273 SAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQEVLVWLEKLRKQVGDNFTEEQLKE 332
SAH HLVGSALSDPYLSFAA LNGLAGPLHGLANQEVL+W++ + ++ G++ ++EQLK+
Sbjct: 239 SAHAGHLVGSALSDPYLSFAAALNGLAGPLHGLANQEVLLWIKLVVEECGESISKEQLKD 298
Query: 333 FIWKTLKSGQVVPGYGHAVLRKTDPRYTCQREFALKHLPNDPLFKLVAAVYKVVPPILTE 392
++WKTL SG+VVPGYGH VLRKTDPRY CQREFALKHLP+DPLF+LV+ +Y+VVPPILTE
Sbjct: 299 YVWKTLNSGKVVPGYGHGVLRKTDPRYICQREFALKHLPDDPLFQLVSKLYEVVPPILTE 358
Query: 393 LGKVKNPWPNVDSHSGVLLQYYGLKEMNYYTVMFGVSRALGVLAQLIWSRALGLPIERPK 452
LGKVKNPWPNVD+HSGVLL YYGL E YYTV+FGVSR+LG+ +QLIW RALGLP+ERPK
Sbjct: 359 LGKVKNPWPNVDAHSGVLLNYYGLTEARYYTVLFGVSRSLGICSQLIWDRALGLPLERPK 418
Query: 453 SLSTEML 459
S++ + L
Sbjct: 419 SVNMDWL 425
>UniRef50_Q95TZ4 Cluster: Citrate synthase; n=1; Drosophila
melanogaster|Rep: Citrate synthase - Drosophila
melanogaster (Fruit fly)
Length = 478
Score = 515 bits (1270), Expect = e-144
Identities = 234/434 (53%), Positives = 324/434 (74%), Gaps = 1/434 (0%)
Query: 33 TNLKSILQEKIPKEQEKIREFRKKHGSTKVGEVTVDMMYGGMRGIKGLVWETSVLDADEG 92
+ LK+ L +KIP E+EK + HG +G+++V+ + GGMRG+ L ETS LD ++G
Sbjct: 31 SGLKAKLAKKIPIEREKFLGIKCLHGKKIIGQISVNSVIGGMRGLPLLFCETSSLDKNKG 90
Query: 93 IRFRGLSIPECQQQLPKAKGG-EEPLPEGLFWLLVTGDIPTEAQAKALSKEWAARAELPA 151
I +RG + + +LP+ + G +E PEG F+LL +G +PT+ +A+ ++ EW R +P
Sbjct: 91 IYYRGKLLKDVCAKLPRVQEGTQEGTPEGCFFLLTSGSMPTKKEAQEVTNEWLKRGSVPR 150
Query: 152 HVVTMLNNMPGKLHPMSQFSAAVTALNSESKFAKAYSEGVHKSKYWEYVYEDTMNLIAKL 211
+ + M+++M ++HPM+Q AA LN +S+F +AY++G ++ YW+Y YED+MNLIA L
Sbjct: 151 YCLRMIDSMDKRVHPMAQLCAASACLNPQSQFVEAYTKGARRADYWKYSYEDSMNLIAML 210
Query: 212 PVIAATIYRNVYRDGKGIGAIDDNKDWSANYCNMLGFDDPQFTELMRLYLTIHSDHEGGN 271
P +AA IY NV+RDG+G ++ +DWS N+C MLG + F +LMRLY+ +H+DHE GN
Sbjct: 211 PTVAAAIYSNVFRDGEGSREVNYEEDWSGNFCRMLGLPEKDFVDLMRLYMILHADHESGN 270
Query: 272 VSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQEVLVWLEKLRKQVGDNFTEEQLK 331
VSAH HLVG+ALSDP+LSF+A + GLAGPLHGLANQEVLVWL KLRK +GD+ ++E+LK
Sbjct: 271 VSAHACHLVGTALSDPFLSFSASMCGLAGPLHGLANQEVLVWLTKLRKAIGDDPSDEELK 330
Query: 332 EFIWKTLKSGQVVPGYGHAVLRKTDPRYTCQREFALKHLPNDPLFKLVAAVYKVVPPILT 391
+FI TLK GQV+PGYGHAVLR TDPR+ Q EFA+KH +DP KLV ++K++P +L
Sbjct: 331 KFIDDTLKGGQVIPGYGHAVLRDTDPRFVLQNEFAMKHCKDDPGVKLVTRLWKIIPEVLK 390
Query: 392 ELGKVKNPWPNVDSHSGVLLQYYGLKEMNYYTVMFGVSRALGVLAQLIWSRALGLPIERP 451
+L KV NP+PNVD+HSGVLLQ+Y LKE+ +YTV+FGVSRALGVL+QLIWSRALG PIERP
Sbjct: 391 KLNKVANPYPNVDAHSGVLLQHYCLKELKFYTVLFGVSRALGVLSQLIWSRALGAPIERP 450
Query: 452 KSLSTEMLMKQVGK 465
KS S+ + K + +
Sbjct: 451 KSFSSIEICKFINE 464
>UniRef50_Q4QDX3 Cluster: Probable citrate synthase, mitochondrial
precursor; n=9; Trypanosomatidae|Rep: Probable citrate
synthase, mitochondrial precursor - Leishmania major
Length = 470
Score = 511 bits (1261), Expect = e-143
Identities = 247/450 (54%), Positives = 322/450 (71%), Gaps = 12/450 (2%)
Query: 25 LRGLSAEQTNLKSILQEKIPKEQEKIREFRKKHGSTKVGEVTVDMMYGGMRGIKGLVWET 84
LR S+ +K + + ++Q+KI + RKKHG K+ + T+D +YGGMRGI GLV+E
Sbjct: 15 LRMASSALDEMKEQMLRRWKEDQKKIDDLRKKHGHEKLCDATIDAVYGGMRGITGLVYEP 74
Query: 85 SVLDADEGIRFRGLSIPECQQQLPKAKGGEEPLPEGLFWLLVTGDIPTEAQAKALSKEWA 144
S+LD EGIRFRGL+I ECQ+ LPKA GG+EPLPE +FWLL+TG++PTE Q + L+ E
Sbjct: 75 SLLDPAEGIRFRGLTILECQEMLPKAPGGKEPLPEAMFWLLMTGEVPTEEQVRGLNAELH 134
Query: 145 ARAELPAHVVTM--LNNMPGKLHPMSQFSAAVTALNSESKFAKAYSEGV-HKSKYWEYVY 201
RA+ A + +P HPM+ FS V AL S SKFA AY+ G +K YWEY
Sbjct: 135 RRADPEAIAAAQKAIAALPRNAHPMTAFSVGVLALQSYSKFAAAYAAGKSNKKTYWEYAL 194
Query: 202 EDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNK-DWSANYCNMLGFDDPQFTELMRLY 260
ED+++++A+ P +AA IY + + A ++ DW+AN+ M+G+ D +F E MRLY
Sbjct: 195 EDSLDMLARTPTVAAMIYNRETKGQVELAAPSNSDLDWAANFAKMMGYQDEEFWECMRLY 254
Query: 261 LTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQEVLVWLEKLRKQ 320
L++H+DHEGGNVSAHTT LV SALSDPYL+F+AGLNGLAGPLHGLANQEVL +L ++++
Sbjct: 255 LSVHADHEGGNVSAHTTTLVASALSDPYLAFSAGLNGLAGPLHGLANQEVLNYLLSMQER 314
Query: 321 V---GDNFTEEQ-----LKEFIWKTLKSGQVVPGYGHAVLRKTDPRYTCQREFALKHLPN 372
V G N +E L + W+ L SGQVVPGYGHAVLRK DPRYTCQR F L+H +
Sbjct: 315 VKADGVNMHDEAALEKALSNYTWELLNSGQVVPGYGHAVLRKVDPRYTCQRNFCLRHKFD 374
Query: 373 DPLFKLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYGLKEMNYYTVMFGVSRAL 432
D LFKLV +Y ++P IL E GK KNP+PNVD+HSGVLLQ+YGL E NYYTV+FG+SR +
Sbjct: 375 DDLFKLVNTIYSIMPGILKEHGKTKNPYPNVDAHSGVLLQHYGLTEQNYYTVLFGLSRQM 434
Query: 433 GVLAQLIWSRALGLPIERPKSLSTEMLMKQ 462
GVLA ++W R G P+ERPKS++TEML K+
Sbjct: 435 GVLAGVVWDRLQGRPLERPKSITTEMLAKK 464
>UniRef50_A0DZ50 Cluster: Citrate synthase; n=6; Paramecium
tetraurelia|Rep: Citrate synthase - Paramecium
tetraurelia
Length = 459
Score = 510 bits (1257), Expect = e-143
Identities = 226/432 (52%), Positives = 320/432 (74%), Gaps = 2/432 (0%)
Query: 35 LKSILQEKIPKEQEKIREFRKKHGSTKVGEVTVDMMYGGMRGIKGLVWETSVLDADEGIR 94
LK ++E +P +Q +R+ RK++G+ +V +VTVD GGMR + GL ++ S+LDA GI
Sbjct: 24 LKKRMRELVPVKQALLRDVRKRYGAKEVCKVTVDQAIGGMRNVFGLFYDASLLDAKTGIT 83
Query: 95 FRGLSIPECQQQLPKAKGGEEPLPEGLFWLLVTGDIPTEAQAKALSKEWAARAELPAHVV 154
R +IPE Q+ L KA+ G EPLPE LFWLL TGD P+E + + +EW R +L +
Sbjct: 84 MRDYNIPELQEYLQKAENGHEPLPEALFWLLCTGDFPSEQEFADVQQEWKQRGQLDSETQ 143
Query: 155 TMLNNMPGKLHPMSQFSAAVTALNSESKFAKAYSEG-VHKSKYWEYVYEDTMNLIAKLPV 213
+ ++P HPM+ S + L +S+F + Y +G V K +YWEY YED M+L+AK+P
Sbjct: 144 KFILSLPKAAHPMTMLSQTLLFLQKDSQFQQVYDQGKVSKPQYWEYFYEDAMDLLAKIPR 203
Query: 214 IAATIYRNVYRDGKGIGAIDDNKDWSANYCNMLGFDDPQFTELMRLYLTIHSDHEGGNVS 273
+AA IYR+ Y++G+ I A DDN DW+ NY +MLG++ + E +R YL+IH+DHEGGNVS
Sbjct: 204 VAALIYRHKYKNGEIISA-DDNLDWAGNYAHMLGYNKFEVRECLRGYLSIHADHEGGNVS 262
Query: 274 AHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQEVLVWLEKLRKQVGDNFTEEQLKEF 333
AHTTHLVGSAL+DPYLS++AG+NGLAGPLHGLANQEVL WL ++R+++G+N + E+++++
Sbjct: 263 AHTTHLVGSALADPYLSYSAGVNGLAGPLHGLANQEVLKWLLEMREELGENISNEKIQDY 322
Query: 334 IWKTLKSGQVVPGYGHAVLRKTDPRYTCQREFALKHLPNDPLFKLVAAVYKVVPPILTEL 393
+ T++ G+V+PGYGHAVLR TDPR+ Q++FA +H+ +DPL LV Y V+PP+L +
Sbjct: 323 VLTTIREGKVIPGYGHAVLRYTDPRFIHQKDFAARHIKDDPLVDLVRQCYHVIPPVLKTI 382
Query: 394 GKVKNPWPNVDSHSGVLLQYYGLKEMNYYTVMFGVSRALGVLAQLIWSRALGLPIERPKS 453
GK++NPWPNVD+HSGVLL +YG++E YYTV+F VSRALG +A LIWSRA GLPIERP S
Sbjct: 383 GKIQNPWPNVDAHSGVLLYHYGMREFQYYTVVFAVSRALGCMANLIWSRAFGLPIERPGS 442
Query: 454 LSTEMLMKQVGK 465
++ + ++ G+
Sbjct: 443 ITMRWIEEKFGE 454
>UniRef50_A6S819 Cluster: Citrate synthase; n=1; Botryotinia
fuckeliana B05.10|Rep: Citrate synthase - Botryotinia
fuckeliana B05.10
Length = 534
Score = 500 bits (1232), Expect = e-140
Identities = 238/435 (54%), Positives = 317/435 (72%), Gaps = 7/435 (1%)
Query: 29 SAEQTNLKSILQEKIPKEQEKIREFRKKHGSTKVGEVTVDMMYGGMRGIKGLVWETSVLD 88
++ + +LK+ +E IP ++E +++ K +G+ +GEV ++ GGMRG+K +VWE SVLD
Sbjct: 62 TSSEPDLKATFKECIPAKRELLKKV-KANGNKVIGEVKIENTIGGMRGLKAMVWEGSVLD 120
Query: 89 ADEGIRFRGLSIPECQQQLPKAKGGEEPLPEGLFWLLVTGDIPTEAQAKALSKEWAARAE 148
ADEGIRF G +I +CQ++LPK K G E LPE +FWLL+TG IP+ +Q + SKE A +A
Sbjct: 121 ADEGIRFHGRTIKDCQKELPKGKSGTEMLPEAMFWLLLTGQIPSTSQVRQFSKELAEQAA 180
Query: 149 LPAHVVTMLNNMPGKLHPMSQFSAAVTALNSESKFAKAYSEGVHKSKYWEYVYEDTMNLI 208
LP V ML+N P LHPM+QF+ AV+AL+ SKFAK+Y +GV+K+ YWE ++D+++L+
Sbjct: 181 LPDFVNKMLDNFPKDLHPMTQFAMAVSALSHTSKFAKSYEKGVNKADYWEPTFDDSISLL 240
Query: 209 AKLPVIAATIYRNVYRDGKGIGA-IDDNKDWSANYCNML---GFDDPQFTELMRLYLTIH 264
AKLPVIAA IY+N Y G + A +D +DWS N+ ML G + F +L+RLYL +H
Sbjct: 241 AKLPVIAAKIYQNSYGGGGALPAQVDLEQDWSYNFAAMLGKGGKKNENFQDLLRLYLALH 300
Query: 265 SDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQEVLVWLEKLRKQVGDN 324
DHEGGNVSAHTTHLVGSALSDP+LS++AGL GLAGPLHGLA QEVL W+ ++++ VG
Sbjct: 301 GDHEGGNVSAHTTHLVGSALSDPFLSYSAGLQGLAGPLHGLAAQEVLRWILQMQEHVGTK 360
Query: 325 FTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPRYTCQREFALK--HLPNDPLFKLVAAV 382
FT++ + +++W TLKSG+VVPGYGHAVLRK DPR+ ++A + DP+F+LV
Sbjct: 361 FTDKDVSDYLWSTLKSGRVVPGYGHAVLRKPDPRFEALMDYASSRPEIAKDPVFQLVKKN 420
Query: 383 YKVVPPILTELGKVKNPWPNVDSHSGVLLQYYGLKEMNYYTVMFGVSRALGVLAQLIWSR 442
++ P IL GK KNP PNVDS SGVL +YG E YYT FGVSR LG LAQLIW R
Sbjct: 421 SEIAPEILKIHGKTKNPHPNVDSSSGVLFHHYGFHETLYYTATFGVSRGLGPLAQLIWDR 480
Query: 443 ALGLPIERPKSLSTE 457
ALGLPIERPK+ ++
Sbjct: 481 ALGLPIERPKNFQSD 495
>UniRef50_Q6JGH9 Cluster: Citrate synthase; n=17;
Desulfuromonadales|Rep: Citrate synthase - Geobacter
metallireducens
Length = 441
Score = 452 bits (1114), Expect = e-126
Identities = 220/432 (50%), Positives = 291/432 (67%), Gaps = 7/432 (1%)
Query: 35 LKSILQEKIPKEQEKIREFRKKHGSTKVGEVTVDMMYGGMRGIKGLVWETSVLDADEGIR 94
LK L++KI + + + K+ G + +VT+D GG R I+ LV + S LD EGIR
Sbjct: 3 LKETLKQKIEEFRPRTTRLVKEFGKVVIDQVTIDQAIGGARDIRSLVTDISYLDPQEGIR 62
Query: 95 FRGLSIPECQQQLPKAKGGEEPLPEGLFWLLVTGDIPTEAQAKALSKEWAARAELPAHVV 154
FRG +IPE + LPKA G + P E ++ L+TG++PT+AQ + EW R +P +V
Sbjct: 63 FRGKTIPETFEALPKASGSDYPTVESFWYFLLTGEVPTQAQVDEVVAEWKTRQVVPQYVF 122
Query: 155 TMLNNMPGKLHPMSQFSAAVTALNSESKFAKAYSEG-VHKSKYWEYVYEDTMNLIAKLPV 213
++ +P + HPM S + AL +SKFA Y+ G +K WEYVYED +L+A++P+
Sbjct: 123 DAISALPKESHPMVMLSVGILALQKDSKFAGFYNSGKFNKMTAWEYVYEDASDLVARIPI 182
Query: 214 IAATIYRNVYRDGKGIGAIDDNKDWSANYCNMLGFDDPQFTELMRLYLTIHSDHEGGNVS 273
IAA IY YR GK AID D AN+ M+G ++ ++ R+Y +HSDHE GNVS
Sbjct: 183 IAAFIYNLKYRGGKQ-SAIDPTADCGANFARMIG-QCKEYEDVARMYFILHSDHESGNVS 240
Query: 274 AHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQEVLVWLEKLRKQVGDNF--TEEQLK 331
AHTTHLV SALSDPY +++AGLNGLAGPLHGLANQEVL W K +++ + T+E +
Sbjct: 241 AHTTHLVHSALSDPYYAYSAGLNGLAGPLHGLANQEVLDWTIKFQQKYCKDVEPTKELVT 300
Query: 332 EFIWKTLKSGQVVPGYGHAVLRKTDPRYTCQREFALK--HLPNDPLFKLVAAVYKVVPPI 389
+ +W TL +GQVVPGYGHAVLRKTDPRY QREF LK L +DPLFKLVA +++ P +
Sbjct: 301 KALWDTLNAGQVVPGYGHAVLRKTDPRYMSQREFCLKTPGLKDDPLFKLVAMIFETAPGV 360
Query: 390 LTELGKVKNPWPNVDSHSGVLLQYYGLKEMNYYTVMFGVSRALGVLAQLIWSRALGLPIE 449
L E GK KNPWPNVD+ SGV+ YYGL+E ++YTV+FGV RALG +A + W R LG IE
Sbjct: 361 LMEHGKAKNPWPNVDAQSGVIQWYYGLREWDFYTVLFGVGRALGCMANITWDRGLGYAIE 420
Query: 450 RPKSLSTEMLMK 461
RPKS++T ML K
Sbjct: 421 RPKSVTTPMLEK 432
>UniRef50_P43635 Cluster: Citrate synthase 3; n=7;
Saccharomycetales|Rep: Citrate synthase 3 -
Saccharomyces cerevisiae (Baker's yeast)
Length = 486
Score = 423 bits (1041), Expect = e-117
Identities = 204/453 (45%), Positives = 295/453 (65%), Gaps = 21/453 (4%)
Query: 28 LSAEQTNLKSILQEKIPKEQEKIREFRKKHGSTKVGEVTVDMMYGGMRGIKGLVWETSVL 87
+ + LK L+ IPK+++ +++ + +GST VG +T+ + GGMRG + + W+ + L
Sbjct: 22 IKSSALTLKEALENVIPKKRDAVKKLKACYGSTFVGPITISSVLGGMRGNQSMFWQGTSL 81
Query: 88 DADEGIRFRGLSIPECQQQLPKAK-GGEEPLPEGLFWLLVTGDIPTEAQAKALSKEWAAR 146
D + GI+F+GL+I ECQ +LP G+ LPE + WLL+TG +PT QA + KE A R
Sbjct: 82 DPEHGIKFQGLTIEECQNRLPNTGIDGDNFLPESMLWLLMTGGVPTFQQAASFRKELAIR 141
Query: 147 A-ELPAHVVTMLNNMPGKLHPMSQFSAAVTALNSESKFAKAYSEG-VHKSKYWEYVYEDT 204
+LP + +L+++P +HPM+Q + + ++N S FA Y +G + K ++W+ ED+
Sbjct: 142 GRKLPHYTEKVLSSLPKDMHPMTQLAIGLASMNKGSLFATNYQKGLIGKMEFWKDTLEDS 201
Query: 205 MNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDWSANYCNMLGFDDP------------- 251
+NLIA LP++ IY N+ +G +G + DW N C++LG +
Sbjct: 202 LNLIASLPLLTGRIYSNITNEGHPLGQYSEEVDWCTNICSLLGMTNGTNSSNTCNLTSQQ 261
Query: 252 --QFTELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQE 309
F LMRLY IH DHEGGNVSAHTTHLVGSALSDPYLS+++G+ GLAGPLHGLA QE
Sbjct: 262 SLDFINLMRLYTGIHVDHEGGNVSAHTTHLVGSALSDPYLSYSSGIMGLAGPLHGLAAQE 321
Query: 310 VLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPRYTCQREFALK- 368
V+ +L ++ + E+++K+++WK L S +V+PGYGHAVLRK DPR+T EFA K
Sbjct: 322 VVRFLIEMNSNISSIAREQEIKDYLWKILNSNRVIPGYGHAVLRKPDPRFTAMLEFAQKR 381
Query: 369 --HLPNDPLFKLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYGLKEMNYYTVMF 426
ND L+ + ++ P +L E GK KNP+PNVDS SG+L +YG++E+ ++TV+F
Sbjct: 382 PIEFENDKNVLLMQKLAEIAPKVLLEHGKSKNPFPNVDSASGILFYHYGIRELLFFTVIF 441
Query: 427 GVSRALGVLAQLIWSRALGLPIERPKSLSTEML 459
G SRA+G L QL+W R LGLPIERPKSL+ E L
Sbjct: 442 GCSRAMGPLTQLVWDRILGLPIERPKSLNLEGL 474
>UniRef50_UPI00006CBE2B Cluster: citrate synthase; n=1; Tetrahymena
thermophila SB210|Rep: citrate synthase - Tetrahymena
thermophila SB210
Length = 474
Score = 420 bits (1035), Expect = e-116
Identities = 198/432 (45%), Positives = 288/432 (66%), Gaps = 11/432 (2%)
Query: 32 QTNLKSILQEKIPKEQEKIREFRKKHGSTKVGEVTVDMMYGGMRGIKGLVWETSVLDADE 91
+ +LK++L+E+IP + + E +KK+G +GE+TV+ GGMRGI+ L ++ S +D +
Sbjct: 22 KADLKTVLREQIPIKIQGFNEMKKKYGDRVMGEITVNQALGGMRGIRALFYDQSTVDPID 81
Query: 92 GIRFRGLSIPECQQQLPKAK--------GGEEPLPEGLFWLLVTGDIPTEAQAKALSKEW 143
G+ FRG SIPE + LPK + ++PLPEGLF+LL+TG++P+ Q + + EW
Sbjct: 82 GVMFRGYSIPELHELLPKLRKPSAEDFQSDQQPLPEGLFFLLLTGELPSYHQVELIRHEW 141
Query: 144 AARAELPAHVVTMLNNMPGKLHPMSQFSAAVTALNSESKFAKAYSEG-VHKSKYWEYVYE 202
R ++ ++ +N + K+HPM+ S A+ SKFA+ Y+E ++KS YWEY YE
Sbjct: 142 DVRGKVSDELINFINRLDNKMHPMTMLSLAILYEQKTSKFAQLYNESKLNKSNYWEYTYE 201
Query: 203 DTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDWSANYCNMLGFDDPQ-FTELMRLYL 261
D+++LIAKLP IAATIYR ++DGK I A D DWSA +M+GF+ + EL+R +L
Sbjct: 202 DSVDLIAKLPRIAATIYRKKFKDGKPI-AHKDGLDWSAQLAHMMGFEGQETLNELLRAFL 260
Query: 262 TIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQEVLVWLEKLRKQV 321
TIH+DHEGG VS H +HLVGSAL DPYL GLAGPLHGLANQEVL W+ +
Sbjct: 261 TIHADHEGGEVSTHASHLVGSALGDPYLCMTTAYTGLAGPLHGLANQEVLKWILNFVEVH 320
Query: 322 GDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPRYTCQREFALKHLPNDPLFKLVAA 381
G + T Q+++++ T+ SG++VPGYGHAVLR+ DPR+ +F K+L ++ + +L+
Sbjct: 321 GYDVTNRQIEDYVNTTVLSGRLVPGYGHAVLRRPDPRFLHLYDFGNKYLRDNEMIRLLHQ 380
Query: 382 VYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYGLKEMNYYTVMFGVSRALGVLAQLIWS 441
+ V+P L + +P+PNVD HSG LL G++E +YTV+F +SR++G L L+W
Sbjct: 381 MTDVIPRRLRTFKNISSPYPNVDCHSGALLYQLGIQEYQFYTVLFAISRSIGCLTNLVWC 440
Query: 442 RALGLPIERPKS 453
RA GLPIERP+S
Sbjct: 441 RAFGLPIERPES 452
>UniRef50_A4ZVV6 Cluster: Mitochondrial citrate synthase 1; n=1;
Toxoplasma gondii|Rep: Mitochondrial citrate synthase 1
- Toxoplasma gondii
Length = 554
Score = 416 bits (1025), Expect = e-115
Identities = 210/434 (48%), Positives = 287/434 (66%), Gaps = 20/434 (4%)
Query: 39 LQEKIPKEQEKIREFRKKHGSTKVGEVTVDMMYGGMRGIKGLVWETSVLDADEGIRFRGL 98
+QE ++E ++ RK+HG+ + E T+ + GGMRG+ ++ ETS L A++GI +RGL
Sbjct: 118 VQEAAEPKRELLKTLRKEHGTVVISEATLSTVCGGMRGLTAILTETSTLHAEKGILYRGL 177
Query: 99 SIPECQQQLPKAKGGEEPLPEGLFWLLVTGDIPTEAQAKALSKEWAARAE---------- 148
+I EC +LP+ E P EGL W L+TG IPT + + LS A +
Sbjct: 178 TINECLAKLPRMHKEEYPAVEGLIWFLMTGSIPTVNEVELLSNALYALSLSSASSSPSAP 237
Query: 149 -LPAHVVTMLNNMPGKLHPMSQFSAAVTALNSESKFAKAYS-EGVHKSKYWEYVYEDTMN 206
+P HV +L+ +P HPM+Q A AL S+ A+AY + V + W+ D ++
Sbjct: 238 FIPPHVGKVLDAVPPSTHPMTQLVMAAAALQPTSELAQAYRHKTVSRHDLWKPALADALS 297
Query: 207 LIAKLPVIAATIYRNVYRDGKGIGAIDDNKDWSANYCNMLGFDDPQFTELMRLYLTIHSD 266
LIAK V+AA I+R +RDG+ I D +AN+ +M+GF+ + EL RLYL +H+D
Sbjct: 298 LIAKNAVMAARIFRRSFRDGQEI-------DPAANFGHMMGFNSKEHQELFRLYLFLHAD 350
Query: 267 HEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQEVLVWLEKLR-KQVGDNF 325
HEGGNVSAH H+VGSALSDP+L+F+AG+ GLAGPLHGLANQE L WL + K G
Sbjct: 351 HEGGNVSAHAAHVVGSALSDPFLAFSAGMAGLAGPLHGLANQECLNWLRDVHCKLNGAAP 410
Query: 326 TEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPRYTCQREFALKHLPNDPLFKLVAAVYKV 385
T E +K+ TL SG+V+PGYGHAVLR TDPR+T QREFALK+L +D LF+L+ Y
Sbjct: 411 TRENVKKIAEDTLASGRVIPGYGHAVLRVTDPRFTAQREFALKYLKDDELFQLLNVAYNT 470
Query: 386 VPPILTELGKVKNPWPNVDSHSGVLLQYYGLKEMNYYTVMFGVSRALGVLAQLIWSRALG 445
+P +L GKVKNP+PNVD HSGVLLQ++G+ E ++YTV+FGVSRA+G+ Q +W R LG
Sbjct: 471 IPDVLLATGKVKNPYPNVDCHSGVLLQHFGITEADFYTVLFGVSRAIGIACQYVWDRILG 530
Query: 446 LPIERPKSLSTEML 459
LPIERPKS + ++L
Sbjct: 531 LPIERPKSTTLDLL 544
>UniRef50_Q4N4H4 Cluster: Citrate synthase, putative; n=3;
Piroplasmida|Rep: Citrate synthase, putative - Theileria
parva
Length = 676
Score = 396 bits (974), Expect = e-109
Identities = 195/440 (44%), Positives = 280/440 (63%), Gaps = 6/440 (1%)
Query: 27 GLSAEQTNLKSILQEKIPKEQEKIREFRKKHGSTKVGEVTVDMMYGGMRGIKGLVWETSV 86
G S L ++ + ++EK+ E K+ ++GEVT+ M++ G++ + +V ETS
Sbjct: 231 GRSKVVERLMDKVERLVNVKREKVAELHNKYADCRLGEVTLSMLFSGLKDVPAMVTETSE 290
Query: 87 LDADEGIRFRGLSIPECQQQLPKAKGGEEPLPEGLFWLLVTGDIPTEAQAKALSKEWAAR 146
LD GIRFRGL++ E LP K + P E + W L+TG++P+ LS E R
Sbjct: 291 LDPFNGIRFRGLTVDEMLTALP-GKNPDCPYTESVLWFLLTGEVPSPVDVDDLSYELYRR 349
Query: 147 AELPAHVVTMLNNMPGKLHPMSQFSAAVTALNSESKFAKAYSEGV-HKSKYWEYVYEDTM 205
+ +P HV +++ P HPM+Q+ AV+AL +ES F +AY + HK W+ ED +
Sbjct: 350 STVPEHVYKVIDGFPTDAHPMTQYITAVSALQTESVFREAYFDKTYHKDTCWKLALEDCL 409
Query: 206 NLIAKLPVIAATIYRNVYRDGKGIGA---IDDNKDWSANYCNMLGFDDPQFTELMRLYLT 262
NL AK V+ IYR + D A + + D++AN + LG F+++MRLYL
Sbjct: 410 NLFAKNVVLVGYIYRRSFIDENTKPADVQYNSSLDYAANLAHFLGNKTELFSDVMRLYLA 469
Query: 263 IHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQEVLVWLEKLRKQV- 321
+HSDHEGGNVSAH +HLVGSAL+DPY F++ L GL+GPLHG+ANQE LVW++K+ +
Sbjct: 470 LHSDHEGGNVSAHASHLVGSALADPYFCFSSALCGLSGPLHGMANQECLVWIKKMLSDLE 529
Query: 322 GDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPRYTCQREFALKHLPNDPLFKLVAA 381
G T E +K++ T+ QV+PGYGHAVL+ TDPR+T FALKH P+DPL KL+
Sbjct: 530 GKEVTVEAVKKYAEDTMARKQVIPGYGHAVLKVTDPRHTAFVRFALKHFPDDPLVKLLDT 589
Query: 382 VYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYGLKEMNYYTVMFGVSRALGVLAQLIWS 441
K +P +L GKV+NP PNVD +GVLL ++ + + +TV+FG+SR++G+L+QL+W+
Sbjct: 590 CLKAIPEVLKASGKVRNPNPNVDCSTGVLLSHFKVDQPQIFTVLFGLSRSMGILSQLVWA 649
Query: 442 RALGLPIERPKSLSTEMLMK 461
RAL PIERPKSLS E + K
Sbjct: 650 RALRYPIERPKSLSLETVEK 669
>UniRef50_A5KE63 Cluster: Citrate synthase, mitochondrial, putative;
n=13; Plasmodium|Rep: Citrate synthase, mitochondrial,
putative - Plasmodium vivax
Length = 569
Score = 382 bits (939), Expect = e-104
Identities = 190/448 (42%), Positives = 288/448 (64%), Gaps = 11/448 (2%)
Query: 25 LRGLSAEQTNLKSILQEK----IPKEQEKIREFRKKHGSTKVGEVTVDMMYGGMRGIKGL 80
+ + E++ + +IL+EK I K +EK++ + +T + T + + GG+R L
Sbjct: 109 INSIDNEESVIMTILKEKTYDCIQKTREKLKAIIHTYPNTPISICTPNNVIGGLRNTITL 168
Query: 81 VWETSVLDADEGIRFRGLSIPECQQQLPK-AKGGEEPLPEGLFWLLVTGDIPTEAQAKAL 139
+ +TS+L+ +GI FRG ++ + + PK + E P+ E + W L+T +IP K
Sbjct: 169 ITDTSILEKRKGILFRGRTVDKILKDFPKWDENCEYPMAEAMLWYLLTKEIPAADDLKLF 228
Query: 140 SKEWAARAE-LPAHVVTMLNNMPGKLHPMSQFSAAVTALNSESKFAKAYSEGVHKSKYWE 198
S+E RA+ +P+ V ++++P HPMSQ + V+ L S S F YSEG+ K YW+
Sbjct: 229 SRELYCRAKKMPSFVFEFIDSIPTFTHPMSQLVSTVSFLESLSLFKIKYSEGILKKDYWK 288
Query: 199 YVYEDTMNLIAKLPVIAATIYRNVYRDG---KGIGA-IDDNKDWSANYCNMLGFDDPQFT 254
Y+ ED ++LIA++ V+ A I++ + D KG G +D + DWSAN+ ++GF++ +
Sbjct: 289 YILEDAVSLIAQIQVVCAYIFKRSFIDNNIKKGEGMNLDIDFDWSANFAKLIGFENDEVK 348
Query: 255 ELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQEVLVWL 314
+L+RLY +HSDHEGGN SAH +HL+GS L +PYLSF+ L+GPLHGLANQE L +L
Sbjct: 349 DLLRLYFLLHSDHEGGNASAHVSHLIGSTLGNPYLSFSGCAIALSGPLHGLANQECLKFL 408
Query: 315 EKLRKQV-GDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPRYTCQREFALKHLPND 373
++K++ G T ++++ L SG+V+PGYGHAVLR DPR+ R FAL H PND
Sbjct: 409 LDIKKKLDGKELTYGFIEKYAKDFLNSGRVIPGYGHAVLRVPDPRFLALRNFALAHFPND 468
Query: 374 PLFKLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYGLKEMNYYTVMFGVSRALG 433
P+ +++ YKV+P IL+ GKVKNP+PNVD +SG LL +YG+K YYTV+F +SR++G
Sbjct: 469 PIVQILEMCYKVIPGILSATGKVKNPYPNVDCYSGSLLHHYGIKYPEYYTVLFALSRSIG 528
Query: 434 VLAQLIWSRALGLPIERPKSLSTEMLMK 461
V++QL+ SR L P+ERPKS+ L K
Sbjct: 529 VMSQLVLSRGLMYPLERPKSVDVHNLKK 556
>UniRef50_UPI00006CFBEC Cluster: Citrate synthase family protein;
n=1; Tetrahymena thermophila SB210|Rep: Citrate synthase
family protein - Tetrahymena thermophila SB210
Length = 551
Score = 339 bits (834), Expect = 8e-92
Identities = 163/321 (50%), Positives = 223/321 (69%), Gaps = 8/321 (2%)
Query: 32 QTNLKSILQEKIPKEQEKIREFRKKHGSTKVGEVTVDMMYGGMRGIKGLVWETSVLDADE 91
QTNLK ++ E IP++Q +++E ++K+G VG+ TV + GGMRG+KGL+ + S D +
Sbjct: 23 QTNLKKVIAEIIPQKQAELKEVKEKYGDKVVGQYTVKQVIGGMRGMKGLMSDLSRCDPYQ 82
Query: 92 GIRFRGLSIPECQQQLPKA------KGGEEPLPEGLFWLLVTGDIPTEAQAKALSKEWAA 145
GI FRG +IP+ ++ LPKA + +EPLPEG+FWLL+TG +PT AQ AL EW
Sbjct: 83 GIIFRGYTIPQLKEFLPKADPKAADQANQEPLPEGIFWLLMTGQLPTHAQVDALKHEWQN 142
Query: 146 RAELPAHVVTMLNNMPGKLHPMSQFSAAVTALNSESKFAKAYSEG-VHKSKYWEYVYEDT 204
R + V + N+P LH M+ S A+ L +SKFAK Y EG + K YWE YED+
Sbjct: 143 RGTVNQDCVNFILNLPKDLHSMTMLSMALLYLQKDSKFAKLYDEGKISKKDYWEPFYEDS 202
Query: 205 MNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDWSANYCNMLGFDDPQFTELMRLYLTIH 264
M+LIAK+P +AA IYR+ YRD K I + D DW+ NY +M+GF+ E +R YL+IH
Sbjct: 203 MDLIAKIPRVAAIIYRHKYRDSKLIDS-DSKLDWAGNYAHMMGFEQHVVKECIRGYLSIH 261
Query: 265 SDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQEVLVWLEKLRKQVGDN 324
DHEGGNVSAHTTHLVGSALSDPYLS++AG+NGLAGPLHGLANQEVL WL + ++ G
Sbjct: 262 CDHEGGNVSAHTTHLVGSALSDPYLSYSAGVNGLAGPLHGLANQEVLKWLLQFIEEKGTK 321
Query: 325 FTEEQLKEFIWKTLKSGQVVP 345
+++ +++++ + SG+VVP
Sbjct: 322 VSDKDIEDYVDHVISSGRVVP 342
Score = 129 bits (312), Expect = 1e-28
Identities = 63/107 (58%), Positives = 74/107 (69%)
Query: 347 YGHAVLRKTDPRYTCQREFALKHLPNDPLFKLVAAVYKVVPPILTELGKVKNPWPNVDSH 406
YGHAVLR TDPR+ Q +F+ HL +D + KL+ V+P L K+ NP+PNVD H
Sbjct: 433 YGHAVLRDTDPRFHHQVDFSKFHLKDDQMIKLLHQCADVIPKKLLTYKKIANPYPNVDCH 492
Query: 407 SGVLLQYYGLKEMNYYTVMFGVSRALGVLAQLIWSRALGLPIERPKS 453
SGVLL GL E YYTV+F VSRALG +A LIWSRA GLPIERP S
Sbjct: 493 SGVLLYSLGLTEYQYYTVVFAVSRALGCMANLIWSRAFGLPIERPGS 539
>UniRef50_UPI00015B4F54 Cluster: PREDICTED: hypothetical protein;
n=1; Nasonia vitripennis|Rep: PREDICTED: hypothetical
protein - Nasonia vitripennis
Length = 479
Score = 256 bits (626), Expect = 1e-66
Identities = 151/451 (33%), Positives = 246/451 (54%), Gaps = 33/451 (7%)
Query: 29 SAEQTNLKSILQEKIPKEQEKIREFRKKHGSTKVGEVTVDMMYGGMRGIKGLVWETSVLD 88
SA T+LK L EKIP + +R+FR++HG V ++TV+ +Y G+ G+ L+ ETS +D
Sbjct: 12 SAGATDLKEALCEKIPLHHDLLRKFRQQHGLDVVSQITVNDIYRGLDGVTALIRETSEID 71
Query: 89 ADEGIRFRGLSIPECQQQLPKAKGGEEPLPEGLFWLLVTGDIPTEAQAKALSKEWAAR-- 146
+ GI++RGLSIPE Q LP+ G+ P PE +FWLL+TGD+PT Q +AL+ +W R
Sbjct: 72 SQCGIKYRGLSIPELYQLLPRR--GKSPSPEAVFWLLLTGDVPTHEQTEALTADWTERRE 129
Query: 147 -----------AELPAHVVTMLNNMPGKLHPMSQFSAAVTALNSESKFAKAYSEGVHKSK 195
E+ V +L +P + P+ + + A+TAL+++ + KA G
Sbjct: 130 RRKDWWWSGSSGEIGGVVGGVLRALPKNVAPVGRLAIALTALDADKHYRKAVESGAMSYT 189
Query: 196 YWEYVYEDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDWSANYCNML-----GFDD 250
YWE++YED+M L+A LP I A + + + + DW + + L GF +
Sbjct: 190 YWEHIYEDSMELLASLPAIVALVSA---CESRPTPLALEKADWVDFFIDCLHNTTDGFTE 246
Query: 251 PQ---FTELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAG-PLHGLA 306
Q + +RLY+ +++D +GG AH ++GS D + AAG+ A P G
Sbjct: 247 AQRQSLADFLRLYIAVNADDDGGIPGAHVAQIMGSCQFDASRALAAGVLAYANEPTSGTL 306
Query: 307 NQEVLVWLEKLRKQVGDNFTEEQLKEFIWKTL-KSGQVVPGYGHAVLRKTDPRYTCQREF 365
Q + +L +L+ VG + L+ F+ + K Q+ GH + + D RYT R+F
Sbjct: 307 FQ-YMDFLVQLQNAVGREPKNDILRNFVSTLIDKRFQIA---GHKIAQFEDTRYTVLRDF 362
Query: 366 ALKHLPNDPLFKLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYGLKEMNYYTVM 425
H+PNDP KL + + + E + ++ ++ + L Q+YGL++MNY ++
Sbjct: 363 VKNHVPNDPEIKLSQELSNIYKKQIKE-ARNRSVVAEQNAIAAPLFQFYGLRDMNYNQLL 421
Query: 426 FGVSRALGVLAQLIWSRALGLPIERPKSLST 456
++RALG++A +IW+ AL P+ERP++ T
Sbjct: 422 LCMARALGIVASMIWTTALNAPVERPRAKCT 452
>UniRef50_UPI0000DB6B6F Cluster: PREDICTED: similar to citrate
synthase; n=1; Apis mellifera|Rep: PREDICTED: similar to
citrate synthase - Apis mellifera
Length = 795
Score = 226 bits (553), Expect = 8e-58
Identities = 144/441 (32%), Positives = 233/441 (52%), Gaps = 49/441 (11%)
Query: 26 RGLSAEQTNLKSILQEKIPKEQEKIREFRKKHGSTKVGEVTVDMMYGGMRGIKGLVWETS 85
RG+ + T+LK L EKIP + +R FR++HGS+ + +VTV+ +Y G+ G+ +V ETS
Sbjct: 27 RGVPSTSTDLKEALCEKIPIHYDLLRNFRQQHGSSVISQVTVENIYQGLNGVNTIVRETS 86
Query: 86 VLDADEGIRFRGLSIPECQQQLPKAKGGEEPLPEGLFWLLVTGDIPTEAQAKALSKEWAA 145
D+ GI++RGL+IPE LP+ G+ P E +FWLL+TGD+PT+ Q +L +W+
Sbjct: 87 ETDSKYGIKYRGLTIPEVITLLPRE--GKSPSAEAVFWLLLTGDVPTKEQTASLIADWSI 144
Query: 146 RAELPAH---------VVTMLNNMPGKLHPMSQFSAAVTALNSESKFAKAYSEGVHKSKY 196
R + V ++L N+P P+ + S A+T S +A G +
Sbjct: 145 RRQKKKDWWSGPGGGIVGSVLQNLPKTTTPLGKLSIALTVFESGKYIQEALKNGALSYTH 204
Query: 197 WEYVYEDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDWSANYCNMLGFDDPQFTEL 256
WEY YED+M L+A LP I I + ++ K +D DW QF
Sbjct: 205 WEYTYEDSMELLATLPAIVGLIAKGELKNLK-----EDTGDW------------VQFL-- 245
Query: 257 MRLYLTIHSDHEGGNV-SAHTTHLVGSALSDPYLSFAAGLNGLA---GPLHGLANQEVLV 312
S++E G V S H T ++G+ S Y++ A LA P G + E +
Sbjct: 246 --------SEYENGGVPSVHITEILGA--SQLYINQALAAGALAYTDEPKSGTMS-EYME 294
Query: 313 WLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPRYTCQREFALKHLPN 372
+ K+++ G EE+LK +I +K ++ G+ + DP+YT + +HLPN
Sbjct: 295 FHSKIQRLFGHESKEEKLKNYIATLIKREKLA---GYQETKFCDPKYTALINYTREHLPN 351
Query: 373 DPLFKLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYGLKEMNYYTVMFGVSRAL 432
DP KL + +++ I+ + K K+ +P ++ + + Q+YGLK+M + V+ +SRAL
Sbjct: 352 DPNVKLSQTLTQILTMIM-KTAKGKDIYPEQNAIAAPIFQFYGLKDMKFNQVLLCMSRAL 410
Query: 433 GVLAQLIWSRALGLPIERPKS 453
G +A +IW++A+ P+E P S
Sbjct: 411 GAIASIIWTKAVNAPVEHPVS 431
>UniRef50_Q6MAA4 Cluster: Putative citrate (Si)-synthase; n=1;
Candidatus Protochlamydia amoebophila UWE25|Rep:
Putative citrate (Si)-synthase - Protochlamydia
amoebophila (strain UWE25)
Length = 386
Score = 192 bits (468), Expect = 2e-47
Identities = 131/397 (32%), Positives = 201/397 (50%), Gaps = 33/397 (8%)
Query: 64 EVTVDMMYGGMRGIKGLVWETSVLDADEGIRFRGLSIPECQQQLPKAKGGEEPLPEGLFW 123
E+T + + G+RG TS +D +G+ + G + E Q P E + +
Sbjct: 7 EITKESLETGLRGYPVGYCTTSSVDPVKGLFYAGHPVSEIDQWEP----------EQVIY 56
Query: 124 LLVTGDIPTEAQAKALSKEWAARAELPAHVVTMLNNMPGKLHPMSQFSAAVTALNSESKF 183
LL G + + S++ RA ++ + +P +HPM FS A+
Sbjct: 57 LLYHGYVGKPEEVSRFSQDLLIRANCSTALIESIEKLPRNIHPMKLFSIALL-------L 109
Query: 184 AKAYSEGVHKSKYWEYVYEDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDWSANYC 243
A + EG K+ Y +ED +NLIAK+P IAAT+ + GK + + N+
Sbjct: 110 ASGF-EG--KNDY----HEDYLNLIAKVPEIAATVINHHAGWGKTKQS-QPQLGYMENFT 161
Query: 244 NMLGFDDPQFTELMRLYL---TIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAG 300
ML D EL R + +H DH GGN+SA V S L D Y S +A + LAG
Sbjct: 162 QMLNVPDANQQELARAFKFFNVLHYDHGGGNLSAFVGKAVASGLEDLYGSMSAAMCALAG 221
Query: 301 PLHGLANQEVLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPRYT 360
P HG ANQ+ L ++ +L +++G++ TEE+L+ I L G+++ G+GHAVLR DPR T
Sbjct: 222 PRHGKANQDCLTFVHQLVEELGEHSTEEELERLIRAHLDKGELIFGFGHAVLRVEDPRAT 281
Query: 361 CQREFALKHLPNDPLFKLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYGLKEMN 420
E ++ + L K+ + KV +L K+ +P+PNVD+ SG+LL G
Sbjct: 282 LLYEVTNQYYASHALVKMAQLLRKVGSKVLQNNPKISDPYPNVDAISGILLTAAGFPCSE 341
Query: 421 YYTVMFGVSRALGVLAQLIWSR-----ALGLPIERPK 452
YYTV+FG++R +G+ Q+++ R G PI RPK
Sbjct: 342 YYTVLFGLARVVGIGRQIVYERKEAREGKGTPIVRPK 378
>UniRef50_P42457 Cluster: Citrate synthase; n=10;
Actinobacteridae|Rep: Citrate synthase - Corynebacterium
glutamicum (Brevibacterium flavum)
Length = 437
Score = 125 bits (302), Expect = 2e-27
Identities = 108/382 (28%), Positives = 185/382 (48%), Gaps = 37/382 (9%)
Query: 87 LDADEGI-RFRGLSIPECQQQLPKAKGGEEPLPEGLFWLLVTGDIPTEAQAKALSKEWAA 145
+D D GI R+RG I + + A E + +LL+ G++PT + + E
Sbjct: 68 IDGDAGILRYRGYDIADLAEN---ATFNE------VSYLLINGELPTPDELHKFNDEIRH 118
Query: 146 RAELPAHVVTMLNNMPGKLHPMSQFSAAVTALNSESKFAKAYSEGVHKSKYWEYVYEDTM 205
L + N P HPM+ +++V L++ Y + ++ + + + T+
Sbjct: 119 HTLLDEDFKSQFNVFPRDAHPMATLASSVNILSTY------YQDQLNPLDEAQ-LDKATV 171
Query: 206 NLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDWSANYCNML-GFD------DPQFTELMR 258
L+AK+P++AA +R R G D++ + N+ M+ G+ DP + +
Sbjct: 172 RLMAKVPMLAAYAHRA--RKGAPYMYPDNSLNARENFLRMMFGYPTEPYEIDPIMVKALD 229
Query: 259 LYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQEVLVWLEKLR 318
L +H+DHE N S T ++GSA ++ ++S A G+N L+GPLHG ANQ VL LE ++
Sbjct: 230 KLLILHADHEQ-NCSTSTVRMIGSAQANMFVSIAGGINALSGPLHGGANQAVLEMLEDIK 288
Query: 319 KQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPRYTCQREFA---LKHLPNDPL 375
G + TE K K + G + G+GH V + DPR +E A L+HL D L
Sbjct: 289 SNHGGDATEFMNKV---KNKEDGVRLMGFGHRVYKNYDPRAAIVKETAHEILEHLGGDDL 345
Query: 376 FKLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYGLKEMNYYTVMFGVSRALGVL 435
L + ++ + + + +PNVD ++G++ + G +++TV+F + R G +
Sbjct: 346 LDLAIKLEEIA--LADDYFISRKLYPNVDFYTGLIYRAMGF-PTDFFTVLFAIGRLPGWI 402
Query: 436 AQLIWS-RALGLPIERPKSLST 456
A A G I RP+ + T
Sbjct: 403 AHYREQLGAAGNKINRPRQVYT 424
>UniRef50_Q59977 Cluster: Citrate synthase; n=37; Bacteria|Rep:
Citrate synthase - Synechocystis sp. (strain PCC 6803)
Length = 397
Score = 124 bits (300), Expect = 4e-27
Identities = 105/389 (26%), Positives = 186/389 (47%), Gaps = 41/389 (10%)
Query: 73 GMRGIKGLVWETSVLDADEGI-RFRGLSIPECQQQLPKAKGGEEPLPEGLFWLLVTGDIP 131
G+ G+ S +D +GI +RG+ I E L K+ E + +LL+ G +P
Sbjct: 14 GLAGVPAAKSRVSHVDGTDGILEYRGIRIEE----LAKSSSFIE-----VAYLLIWGKLP 64
Query: 132 TEAQAKALSKEWAARAELPAHVVTMLNNMPGKLHPMSQFSAAVTALNSESKFAKAYSEGV 191
T+A+ + E + H+ M+ P HPM + AL +A+ +
Sbjct: 65 TQAEIEEFEYEIRTHRRIKYHIRDMMKCFPETGHPMDALQTSAAALGLF--YARRALDDP 122
Query: 192 HKSKYWEYVYEDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDWSANYCNMLGFD-- 249
+Y+ + L+AK+P + A + + R+G +D D+++N+ ML
Sbjct: 123 ------KYIRAAVVRLLAKIPTMVAAFH--MIREGNDPIQPNDKLDYASNFLYMLTEKEP 174
Query: 250 DPQFTELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQE 309
DP ++ + LT+H++H N S + + S L+DPY A+ + LAGPLHG AN+E
Sbjct: 175 DPFAAKVFDVCLTLHAEHTM-NASTFSARVTASTLTDPYAVVASAVGTLAGPLHGGANEE 233
Query: 310 VLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPRYTCQREFA--- 366
VL LE ++G + E ++ ++ K L + Q + G+GH V + DPR ++ A
Sbjct: 234 VLNMLE----EIG---SVENVRPYVEKCLANKQRIMGFGHRVYKVKDPRAIILQDLAEQL 286
Query: 367 LKHLPNDPLFKLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYGLKEMNYYTVMF 426
+ +D +++ + KVV + + K +PNVD +SG++ + + + +T +F
Sbjct: 287 FAKMGHDEYYEIAVELEKVVEEYVGQ----KGIYPNVDFYSGLVYRKLDI-PADLFTPLF 341
Query: 427 GVSRALGVLAQLIWSRALGL-PIERPKSL 454
++R G LA W L + I RP +
Sbjct: 342 AIARVAGWLAH--WKEQLSVNKIYRPTQI 368
>UniRef50_Q8ZWP2 Cluster: Citrate synthase; n=7;
Thermoproteaceae|Rep: Citrate synthase - Pyrobaculum
aerophilum
Length = 409
Score = 124 bits (299), Expect = 5e-27
Identities = 114/374 (30%), Positives = 182/374 (48%), Gaps = 37/374 (9%)
Query: 80 LVWETSV--LDADEGIR-FRGLSIPECQQQLPKAKGGEEPLPEGLFWLLVTGDIPTEAQA 136
L+ TS+ +D ++GI +RG I E L + EE + +L++ G +PT+ +
Sbjct: 30 LIKSTSISDIDGEKGILWYRGYRIEE----LARLSTYEE-----VSYLILYGRLPTKREL 80
Query: 137 KALSKEWAARAELPAHVVTMLNNMPGKLHPMSQFSAAVTALNS----ESKFAKAYSEGVH 192
+ EL V ++ N+ K HPM AAV A + K +A S G +
Sbjct: 81 EDYINRMKKYRELHPATVEVIRNL-AKAHPMFALEAAVAAEGAYDEDNQKLIEALSVGRY 139
Query: 193 KSKYWEYVYEDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDWSANYCNML-GFD-D 250
K++ E Y L+AK+P I A YR + G + D+ +AN+ M+ G + D
Sbjct: 140 KAEEKELAYRIAEKLVAKMPTIVAYHYR--FSRGLEVVRPRDDLGHAANFLYMMFGREPD 197
Query: 251 PQFTELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQEV 310
P + + LYL +H+DHE S H+V S LSD Y S AA + L GPLHG AN+
Sbjct: 198 PLASRGIDLYLILHADHEVP-ASTFAAHVVASTLSDLYSSVAAAIAALKGPLHGGANEMA 256
Query: 311 LVWLEKLRKQVGDNFTEEQLKEFIWKTLK-SGQVVPGYGHAVLRKTDPRYTCQREFALKH 369
+ + ++G T + KE + K G + G GH V + DPR +EF+ +
Sbjct: 257 V----RNYLEIG---TPAKAKEIVEAATKPGGPKLMGVGHRVYKAYDPRAKIFKEFSRDY 309
Query: 370 LP--NDP--LFKLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYGLKEMNYYTVM 425
+ DP LF + +A+ + V + + + +PNVD SG+ Y G+ Y+T +
Sbjct: 310 VAKFGDPQNLFAIASAIEQEV--LSHPYFQQRKLYPNVDFWSGIAFYYMGI-PYEYFTPI 366
Query: 426 FGVSRALGVLAQLI 439
F +SR +G +A ++
Sbjct: 367 FAMSRVVGWVAHVL 380
>UniRef50_Q4FLH9 Cluster: Citrate (Si)-synthase; n=3; Bacteria|Rep:
Citrate (Si)-synthase - Pelagibacter ubique
Length = 374
Score = 122 bits (294), Expect = 2e-26
Identities = 96/328 (29%), Positives = 159/328 (48%), Gaps = 27/328 (8%)
Query: 119 EGLFWLLVTGDIPTEAQAKALSKEWAARAELPAHVVTMLNNMPGKLHPMSQFSAAVTALN 178
E + +L++ ++P + Q K KE + L +++++L +P HPM AV+ +
Sbjct: 46 EEVAYLILNKELPNKKQLKEFKKELSKEITLSKNLLSILKKIPKNSHPMDVARTAVSVMG 105
Query: 179 SESKFAKAYSEGVHKSKYWEYVYEDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDW 238
E K K S + K + ++AK P A YR R GK I A N +
Sbjct: 106 LEDKETKDSSPKANLRK--------AIRILAKTPTALAAFYR--LRKGKKIIAPKKNLTF 155
Query: 239 SANYCNMLGFDDPQFTELMRLY---LTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGL 295
S N+ +M P+ E+++ + L ++++H NVS T + S+LSD + + +
Sbjct: 156 SGNFFHMCFGKVPE-KEIVKAFDVSLILYAEHSF-NVSTFTARTITSSLSDIHGAITGAI 213
Query: 296 NGLAGPLHGLANQEVLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKT 355
L GPLHG AN+EV+ ++K++K E LK +I K LK+ VV G+GH V +
Sbjct: 214 ASLKGPLHGGANEEVMHMMKKIKK------PENALK-WITKALKNKDVVMGFGHRVYKSG 266
Query: 356 DPRYTCQREFALKHLPNDPLFKLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYG 415
D R RE+ K + K +Y +V ++ K KN +PNVD +G G
Sbjct: 267 DSRVPTMREY-FKRVAIIKKDKTFEKIYDIVEKVMI---KEKNIYPNVDYPTGPTYHLMG 322
Query: 416 LKEMNYYTVMFGVSRALGVLAQLIWSRA 443
+ +++T +F +SR G A ++ A
Sbjct: 323 F-DTDFFTPIFVISRITGWSAHIMEQHA 349
>UniRef50_Q9LXS6 Cluster: Citrate synthase 2, peroxisomal precursor;
n=10; cellular organisms|Rep: Citrate synthase 2,
peroxisomal precursor - Arabidopsis thaliana (Mouse-ear
cress)
Length = 514
Score = 115 bits (276), Expect = 3e-24
Identities = 105/391 (26%), Positives = 182/391 (46%), Gaps = 42/391 (10%)
Query: 87 LDADEGI-RFRGLSIPECQQQLPKAKGGEEPLPEGLFWLLVTGDIPTEAQAKALSKEWAA 145
+D DEGI R+RG I E + + + +LL+ G++P+++Q +
Sbjct: 112 IDGDEGILRYRGYPIEELAESSTFIE---------VAYLLMYGNLPSQSQLADWEFTVSQ 162
Query: 146 RAELPAHVVTMLNNMPGKLHPMSQFSAAVTALNSESKFAKAYSEG--VHKSKYWEYVYED 203
+ +P V+ ++ +MP HPM +A++AL+ A G ++KSK + +
Sbjct: 163 HSAVPQGVLDIIQSMPHDAHPMGVLVSAMSALSIFHPDANPALSGQDIYKSK--QVRDKQ 220
Query: 204 TMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDWSANYCNMLGF-------DDPQFTEL 256
+ ++ K P IAA Y + G+ N +S N+ ML +P+ +
Sbjct: 221 IVRILGKAPTIAAAAY--LRTAGRPPVLPSANLSYSENFLYMLDSMGNRSYKPNPRLARV 278
Query: 257 MRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQEVLVWLEK 316
+ + +H++HE +A HL S + D Y + A + L GPLHG AN+ VL K
Sbjct: 279 LDILFILHAEHEMNCSTAAARHLASSGV-DVYTACAGAVGALYGPLHGGANEAVL----K 333
Query: 317 LRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPRYTCQREFA---LKHLPND 373
+ ++G T E + +FI + + G+GH V + DPR ++ A + D
Sbjct: 334 MLAEIG---TAENIPDFIEGVKNRKRKMSGFGHRVYKNYDPRAKVIKKLADEVFSIVGRD 390
Query: 374 PLFKLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYGLKEMNYYTVMFGVSRALG 433
PL ++ A+ K + E + +PNVD +SG++ + G ++TV+F V R G
Sbjct: 391 PLIEVAVALEKAA--LSDEYFVKRKLYPNVDFYSGLIYRAMGFPP-EFFTVLFAVPRMAG 447
Query: 434 VLAQLIWSRALGLP---IERPKSLSTEMLMK 461
L+ W +L P I RP+ T + M+
Sbjct: 448 YLSH--WRESLDDPDTRIMRPQQAYTGVWMR 476
>UniRef50_Q2JTT9 Cluster: 2-methylcitrate synthase/citrate synthase
II; n=5; Bacteria|Rep: 2-methylcitrate synthase/citrate
synthase II - Synechococcus sp. (strain JA-3-3Ab)
(Cyanobacteria bacteriumYellowstone A-Prime)
Length = 378
Score = 113 bits (272), Expect = 9e-24
Identities = 99/370 (26%), Positives = 165/370 (44%), Gaps = 39/370 (10%)
Query: 73 GMRGIKGLVWETSVLDADEGI-RFRGLSIPECQQQLPKAKGGEEPLPEGLFWLLVTGDIP 131
G+ G+ S +D GI +RG+ I E Q + +LL+ G +P
Sbjct: 9 GLEGVPATRSNISFVDGQAGILEYRGIPIEELTAQSTFLETA---------YLLIFGKLP 59
Query: 132 TEAQAKALSKEWAARAELPAHVVTMLNNMPGKLHPMSQFSAAVTALNSESKFAKAYSEGV 191
T+A+ + + + + M+ + P HPM V +L +A +
Sbjct: 60 TQAELDNFDQAVRSHRRVKYRIRDMIKSFPESGHPMDALQTCVASLGMFYPVREADPD-- 117
Query: 192 HKSKYWEYVYEDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDWSANYCNMLGFD-- 249
YV+ L++KLP + A ++ R G DD+ D +AN+ ML
Sbjct: 118 -------YVFGTVTRLLSKLPTMVAMFHQ--MRQGNDPIPPDDSLDHAANFLYMLSGKKP 168
Query: 250 DPQFTELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQE 309
DP + L +H++H N S + S L+ PY S A + L+G LHG ANQ+
Sbjct: 169 DPWLARIFDTCLILHAEHTV-NASTFALLVSASTLASPYSSLATAVGTLSGLLHGGANQQ 227
Query: 310 VLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPRYTCQREFA--- 366
V+ +L +Q+G + E ++ FI + L + + G GH V + DPR T + A
Sbjct: 228 VM----RLLRQIG---SVENVRSFIEEKLAKKERIMGMGHRVYKVKDPRATILQRLAEEL 280
Query: 367 LKHLPNDPLFKLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYGLKEMNYYTVMF 426
+ +D + + V +V +L K +PNVD +SG++ G+ E + +T +F
Sbjct: 281 FERYGHDKYYDIALEVERVCEELLGP----KGIYPNVDFYSGLVYAKLGIPE-DLFTPVF 335
Query: 427 GVSRALGVLA 436
++RA G LA
Sbjct: 336 AIARAAGWLA 345
>UniRef50_Q550V8 Cluster: Citrate synthase; n=3; Dictyostelium
discoideum|Rep: Citrate synthase - Dictyostelium
discoideum AX4
Length = 512
Score = 113 bits (272), Expect = 9e-24
Identities = 112/430 (26%), Positives = 192/430 (44%), Gaps = 44/430 (10%)
Query: 42 KIPKEQEKIR--EFRK-KHGSTKVGEVTVDMMYGGMRGIKGLVWETSVLDADEGI-RFRG 97
+IP E ++ +FR K S G + D Y K + + +D D GI +RG
Sbjct: 31 EIPINHETVKSIDFRAIKEQSIDFGTMIYDPGYYNTAVCKSQI---TYIDGDRGILEYRG 87
Query: 98 LSIPECQQQLPKAKGGEEPLPEGLFWLLVTGDIPTEAQAKALSKEWAARAELPAHVVTML 157
I +QL + E + +LL+ GD+P++ Q+ + + + ++++M+
Sbjct: 88 YPI----EQLAEKSSFLE-----VSYLLIYGDLPSKEQSNLWNTKIMNHTFIHENLISMM 138
Query: 158 NNMPGKLHPMSQFSAAVTALNSESKFAKAYSEGVHKSKYWEYVYEDTMNLIAKLPVIAAT 217
+ HPM ++++A+++ A GV K + + + ++ KLP IAA
Sbjct: 139 KSFRYDAHPMGMLISSLSAMSTFYPEANPALAGVDIYKNKQLMNKQIFRILGKLPTIAAC 198
Query: 218 IYRNVYRDGKGIGAIDDNKDWSANYCNMLG-------FDDPQFTELMRLYLTIHSDHEGG 270
YR +R G+ + ++ N+ ML P T + IH+DHE
Sbjct: 199 AYR--HRIGRPYNDPSNTLSYTENFLYMLDRLSESNYKPHPVLTRALDKLFIIHADHE-L 255
Query: 271 NVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQEVLVWLEKLRKQVGDNFTEEQL 330
N S T + S L DPY + A L GPLHG AN+ VL LE + T E +
Sbjct: 256 NCSTATMRQIASTLVDPYTACAGSAGALYGPLHGGANEAVLRMLEAIG-------TIENI 308
Query: 331 KEFIWKTLKSGQVVPGYGHAVLRKTDPRYTCQREFALK---HLPNDPLFKLVAAVYKVVP 387
+FI + + Q + G+GH V + DPR + ++ L +PL ++ + ++
Sbjct: 309 PKFIEQVKQKKQRLMGFGHRVYKSYDPRAKILKTVTMEIFALLGKNPLMQIATELERLA- 367
Query: 388 PILTELGKVKNPWPNVDSHSGVLLQYYGLKEMNYYTVMFGVSRALGVLAQLIWSRALGLP 447
+ + +PNVD +SG++ + G + + V+F + RA G LA W L P
Sbjct: 368 -LSDSYFIERQLYPNVDFYSGIIYKSMGF-PTDMFPVLFSIPRAAGWLAH--WVEELADP 423
Query: 448 ---IERPKSL 454
I RP+ +
Sbjct: 424 ELRIFRPRQI 433
>UniRef50_Q7NZ52 Cluster: Citrate (Si)-synthase; n=4; Bacteria|Rep:
Citrate (Si)-synthase - Chromobacterium violaceum
Length = 435
Score = 111 bits (268), Expect = 3e-23
Identities = 100/351 (28%), Positives = 161/351 (45%), Gaps = 41/351 (11%)
Query: 123 WLLVTGDIPTEAQAKALSKEWAARAELPAHVVTMLNNMPGKLHPMSQFSAAVTALNSESK 182
+LL+ G++PT AQ K + L ++++ HPM+ V AL++
Sbjct: 96 YLLLNGELPTAAQRKEFERGVMRHNMLHDQLMSLFKGFRRDAHPMAVMVGVVGALSA--- 152
Query: 183 FAKAYSEGVHKSKYWEYVYEDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDWSANY 242
Y + + S E+ LIAKLP IAA YR Y G + ++ N+
Sbjct: 153 ---FYHDSLDISNP-EHRRISAHRLIAKLPTIAAQAYR--YNKGLPFSYPKNGLTYAENF 206
Query: 243 CNMLGFD-------DPQFTELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGL 295
+M+ +P + T+H+DHE N S T L GS+ ++P+ AA +
Sbjct: 207 LHMMFSTPCEEYKVNPVLARALDRIFTLHADHEQ-NASTSTVRLAGSSGANPFACIAACI 265
Query: 296 NGLAGPLHGLANQEVLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKT 355
L GP HG AN+ VL K+ ++G + + + +F+ + G+GH V +
Sbjct: 266 ACLWGPSHGGANEAVL----KMLDEIG---SVDNVADFMQGVKDKRYKLMGFGHRVYKNM 318
Query: 356 DPR-----YTCQREFALKHLPNDPLFKLVAAVYKVV--PPILTELGKVKNPWPNVDSHSG 408
DPR TC L NDP FKL + K+ P E + +PNVD +SG
Sbjct: 319 DPRAAIMKQTCDEVLNELGLHNDPKFKLAMELEKIALSDPYFIE----RKLYPNVDFYSG 374
Query: 409 VLLQYYGLKEMNYYTVMFGVSRALGVLAQLIWSRALGLP---IERPKSLST 456
++L G+ ++ +T +F ++R +G +A W+ +G P I RP+ L T
Sbjct: 375 IVLSAIGI-PVSMFTPIFALARTVGWIAH--WNEMIGDPGMKIGRPRQLYT 422
>UniRef50_A6ERK5 Cluster: Citrate synthase; n=1; unidentified
eubacterium SCB49|Rep: Citrate synthase - unidentified
eubacterium SCB49
Length = 451
Score = 111 bits (267), Expect = 4e-23
Identities = 116/422 (27%), Positives = 193/422 (45%), Gaps = 44/422 (10%)
Query: 46 EQEKIREFRKKHGSTKVGEVTVDMMYGGMRGIKGLVWETSVLDADEGI-RFRGLSIPECQ 104
E E + + G T G T+D Y + + + L+ +EGI R+RG SI E
Sbjct: 46 ENETAIDIKTLRGQTG-GVTTIDPGYKNTGACESAI---TFLNGEEGILRYRGYSIEELA 101
Query: 105 QQLPKAKGGEEPLPEGLFWLLVTGDIPTEAQAKALSKEWAARAELPAHVVTMLNNMPGKL 164
+ KA E + +LL+ G++PT+AQ + + + + +L+ P
Sbjct: 102 E---KASFLE------VAYLLIFGELPTQAQLDNFHSDIKEESVVDDDLKKILDAFPKSA 152
Query: 165 HPMSQFSAAVTALNSESKFAKAYSEGVHKSKYWEYVYEDTMNLIAKLPVIAATIYRNVYR 224
HPM S+ +AL A++ + E +Y+ + ++ K PV+ A R +
Sbjct: 153 HPMGVLSSLTSALT-------AFNPSSVNVESDEDMYKAIVKILGKFPVLVAWTMRK--Q 203
Query: 225 DGKGIGAIDDNKDWSANYCNMLGFDDPQ--------FTELMRLYLTIHSDHEGGNVSAHT 276
G + D + + N M+ F+ P + L +H+DHE N S T
Sbjct: 204 KGLPLNYGDSSIGYVENILKMM-FEKPNEDYKQNDILLNALDKLLILHADHEQ-NCSTST 261
Query: 277 THLVGSALSDPYLSFAAGLNGLAGPLHGLANQEVLVWLEKLRKQVGDNFTEEQLKEFIWK 336
+VGS+ + Y S +AG++ L GPLHG ANQ VL LE +++ GD K+F+ K
Sbjct: 262 VRIVGSSHAGLYSSLSAGISALWGPLHGGANQAVLEMLEAIKEDGGDT------KKFMAK 315
Query: 337 TLKSGQV--VPGYGHAVLRKTDPRYTCQREFALKHLPNDPLFKLVAAVYK-VVPPILTEL 393
+ G+GH V + DPR + A + L + + V + K + L++
Sbjct: 316 AKDKSDPFRLMGFGHRVYKNFDPRAKIIKVAADEVLGDLGIKDPVLDIAKGLSSEALSDS 375
Query: 394 GKV-KNPWPNVDSHSGVLLQYYGLKEMNYYTVMFGVSRALGVLAQLIWSRALGLPIERPK 452
V + +PNVD +SG++ + G+ + +TVMF + R G +AQ R PI RP+
Sbjct: 376 YFVDRKLYPNVDFYSGIIYRAMGI-PVEMFTVMFALGRLPGWIAQWKEMRQRKEPIGRPR 434
Query: 453 SL 454
+
Sbjct: 435 QV 436
>UniRef50_Q9RWB2 Cluster: Citrate synthase; n=7; Deinococci|Rep:
Citrate synthase - Deinococcus radiodurans
Length = 377
Score = 111 bits (266), Expect = 5e-23
Identities = 89/335 (26%), Positives = 155/335 (46%), Gaps = 22/335 (6%)
Query: 107 LPKAKGGEEPLPEGLFWLLVTGDIPTEAQAKALSKEWAARAELPAHVVTMLNNMPGKLHP 166
+P + E+ E L L+ +PT + E A +P +V ++ +MP +HP
Sbjct: 33 IPIQEWAEKSTFEELSLALLDAKLPTAEELAKFDAELKANRAIPDQLVGIIRDMPKGVHP 92
Query: 167 MSQFSAAVTALNSESKFAKAYSEGVHKSKYWEYVYEDTMNLIAKLPVIAATIYRNVYRDG 226
M AV+ L A+ + ++ + +IA+ I A I R ++G
Sbjct: 93 MQALRTAVSYLGLLDPQAEDITPEARRAI--------STRMIAQFSTIIAAINRA--QEG 142
Query: 227 KGIGAIDDNKDWSANYCNMLGFDDP--QFTELMRLYLTIHSDHEGGNVSAHTTHLVGSAL 284
+ I A + + N+ ML ++P + L + L +H+DH G N S T S L
Sbjct: 143 QDIVAPRADLTHAGNFLYMLTGNEPTPEQARLFDIALVLHADH-GMNASTFTAIATSSTL 201
Query: 285 SDPYLSFAAGLNGLAGPLHGLANQEVLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVV 344
SD Y + + L GPLHG AN+ V+ L+ ++G T ++ + +I L + + +
Sbjct: 202 SDMYSCMVSAIGALKGPLHGGANEAVMTMLD----EIG---TVDKAEAYITGKLDNKEKI 254
Query: 345 PGYGHAVLRKTDPRYTCQREFALKHLPNDPLFKLVAAVYKVVPPILTELGKVKNPWPNVD 404
G GH V + DPR R++A +H+ N + + + I+ + K +PNVD
Sbjct: 255 MGVGHRVYKYFDPRSRVLRDYA-EHVANKEGKSNYYQILEAIEKIIVDRMGAKGIYPNVD 313
Query: 405 SHSGVLLQYYGLKEMNYYTVMFGVSRALGVLAQLI 439
+SG + G+K+ Y+T +F ++R G A +I
Sbjct: 314 FYSGTVYSDLGIKK-EYFTPIFALARISGWCASVI 347
>UniRef50_Q53554 Cluster: Citrate synthase; n=3; Archaea|Rep:
Citrate synthase - Pyrococcus furiosus
Length = 377
Score = 109 bits (263), Expect = 1e-22
Identities = 92/323 (28%), Positives = 159/323 (49%), Gaps = 27/323 (8%)
Query: 119 EGLFWLLVTGDIPTEAQAKALSKEWAARAELPAHVVTMLNNMPGKLHPMSQFSAAVTALN 178
E + +LL G +P+ ++ + KE A LP V+ ++ +P HPM ++ L
Sbjct: 48 EEVVYLLWWGKLPSLSELENFKKELAKSRGLPKEVIEIMEALPKNTHPMGALRTIISYLG 107
Query: 179 SESKFAKAYSEGVHKSKYWEYVYEDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDW 238
+ S + + E VY +++ AK+P I A YR ++G +
Sbjct: 108 NIDD-----SGDIPVTP--EEVYRIGISVTAKIPTIVANWYR--IKNGLEYVPPKEKLSH 158
Query: 239 SANYCNMLGFDDP--QFTELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLN 296
+AN+ ML ++P ++ + M + L ++++HE N S VGS LSD Y + AG+
Sbjct: 159 AANFLYMLHGEEPPKEWEKAMDVALILYAEHEI-NASTLAVMTVGSTLSDYYSAILAGIG 217
Query: 297 GLAGPLHGLANQEVLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTD 356
L GP+HG A +E + KQ + + E+++E+ +K L+ + + G GH V + D
Sbjct: 218 ALKGPIHGGAVEEAI-------KQFMEIGSPEKVEEWFFKALQQKRKIMGAGHRVYKTYD 270
Query: 357 PRYTCQREFALKHLPNDPLFKLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYGL 416
PR +++A K L + LF++ + ++V L++ K NVD SG L +YG+
Sbjct: 271 PRARIFKKYASK-LGDKKLFEIAERLERLVEEYLSK----KGISINVDYWSG--LVFYGM 323
Query: 417 K-EMNYYTVMFGVSRALGVLAQL 438
K + YT +F + R G A L
Sbjct: 324 KIPIELYTTIFAMGRIAGWTAHL 346
>UniRef50_Q10530 Cluster: Citrate synthase 1; n=288; cellular
organisms|Rep: Citrate synthase 1 - Mycobacterium
tuberculosis
Length = 431
Score = 109 bits (263), Expect = 1e-22
Identities = 107/388 (27%), Positives = 175/388 (45%), Gaps = 41/388 (10%)
Query: 61 KVGEVTVDMMYGGMRGIKGLVWETSVLDADEGI-RFRGLSIPECQQQLPKAKGGEEPLPE 119
K G T D+ + K + + +D D GI R+RG I + ++ +
Sbjct: 39 KTGHTTFDVGFANTAAAKSSI---TYIDGDAGILRYRGYPIDQLAEKSTFIE-------- 87
Query: 120 GLFWLLVTGDIPTEAQAKALSKEWAARAELPAHVVTMLNNMPGKLHPMSQFSAAVTALNS 179
+ +LL+ G++P Q + L + + P HPM S+ V AL++
Sbjct: 88 -VCYLLIYGELPDTDQLAQFTGRIQRHTMLHEDLKRFFDGFPRNAHPMPVLSSVVNALSA 146
Query: 180 ESKFAKAYSEGVHKSKYWEYVYEDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDWS 239
Y + + + V T+ L+AKLP IAA Y+ G+ D++
Sbjct: 147 Y------YQDALDPMDNGQ-VELSTIRLLAKLPTIAAYAYKKSV--GQPFLYPDNSLTLV 197
Query: 240 ANYCNM-LGFD------DPQFTELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFA 292
N+ + GF DP+ + + +H+DHE N S T LVGS+ ++ + S +
Sbjct: 198 ENFLRLTFGFPAEPYQADPEVVRALDMLFILHADHEQ-NCSTSTVRLVGSSRANLFTSIS 256
Query: 293 AGLNGLAGPLHGLANQEVLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVL 352
G+N L GPLHG ANQ VL LE +R GD+ +E K K ++G + G+GH V
Sbjct: 257 GGINALWGPLHGGANQAVLEMLEGIRDS-GDDVSEFVRKV---KNREAGVKLMGFGHRVY 312
Query: 353 RKTDPRYTCQREFA---LKHLPNDPLFKLVAAVYKVVPPILTELGKVKNP-WPNVDSHSG 408
+ DPR +E A L L D L+ ++ LT+ ++ +PNVD ++G
Sbjct: 313 KNYDPRARIVKEQADKILAKLGGDD--SLLGIAKELEEAALTDDYFIERKLYPNVDFYTG 370
Query: 409 VLLQYYGLKEMNYYTVMFGVSRALGVLA 436
++ + G +TV+F + R G +A
Sbjct: 371 LIYRALGF-PTRMFTVLFALGRLPGWIA 397
>UniRef50_Q9WYC6 Cluster: Citrate synthase; n=2; Thermotoga|Rep:
Citrate synthase - Thermotoga maritima
Length = 367
Score = 107 bits (257), Expect = 6e-22
Identities = 100/376 (26%), Positives = 175/376 (46%), Gaps = 47/376 (12%)
Query: 69 MMYGGMRGIKGLVWETSV--LDADEG-IRFRGLSIPECQQQLPKAKGGEEPLPEGLFWLL 125
M+ G+ G+K + E+S+ LD G + +RG+ + E E+ E + L
Sbjct: 1 MIQKGLEGVK--ICESSICYLDGINGRLYYRGIPVEEL---------AEKSTFEETAYFL 49
Query: 126 VTGDIPTEAQAKALSKEWAARAELPAHVVTMLNNMPGKLHPMSQFSAAVTALNSESKFAK 185
G +PT+++ + ++ A ELPA + +L ++P LH + ++ S
Sbjct: 50 WYGKLPTKSELEEFKRKMADYRELPAEALGILYHLPKNLHYIDVLKIFLSIHGS------ 103
Query: 186 AYSEGVHKSKYWEYVYEDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDWS--ANYC 243
+G E + E + + + P I A YR Y GK + I KD S N+
Sbjct: 104 --MDGND-----EDLREKAIRVASVFPTILAYYYR--YSKGKEL--IRPRKDLSHVENFY 152
Query: 244 NMLGFDDPQFTELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLH 303
M+ + + L+ + + + N S ++ S LSD Y L L GPLH
Sbjct: 153 YMMFGERNEKIRLLESAFILLMEQDI-NASTFAALVIASTLSDLYSCIVGALGALKGPLH 211
Query: 304 GLANQEVLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPRYTCQR 363
G A+++V LE ++G +E++++EF+ K LK + + G+GH V + DPR +
Sbjct: 212 GGASEKVPPMLE----EIG---SEDRVEEFVQKCLKEKRKIMGFGHRVYKTYDPRAVFLK 264
Query: 364 EFALKHLPNDPLFKLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYGLKEMNYYT 423
+H P+ LF++ + + + + K+KN +PNVD +S VL + G N +T
Sbjct: 265 RVLQEHFPDSKLFRIASKLEEYIVS-----NKIKNIYPNVDLYSSVLFEELGFPR-NMFT 318
Query: 424 VMFGVSRALGVLAQLI 439
+F +R +G A +I
Sbjct: 319 ALFATARVVGWTAHVI 334
>UniRef50_UPI000023D08B Cluster: hypothetical protein FG02352.1;
n=1; Gibberella zeae PH-1|Rep: hypothetical protein
FG02352.1 - Gibberella zeae PH-1
Length = 496
Score = 107 bits (256), Expect = 8e-22
Identities = 92/350 (26%), Positives = 160/350 (45%), Gaps = 29/350 (8%)
Query: 123 WLLVTGDIPTEAQAKALSKEWAARAELPAHVVTMLNNMPGKLHPMSQFSAAVTALNSESK 182
+LL+ G++PT+++ E + + + M + HPMS +AA L + +
Sbjct: 106 YLLIYGELPTKSEYDLWHGEVMHHTYIHSDIENMFKSFRYDSHPMSMLTAAFATLGAFAP 165
Query: 183 FA-------KAYSEGVHKS-KYWEYVYEDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDD 234
A K Y+ + + + + + + ++ K P +AA YR R G+
Sbjct: 166 EANPSLAGQKLYTNAASGNLEALQMLDKQILRILGKAPTLAAASYR--MRQGRPFNRPAQ 223
Query: 235 NKDWSANYCNMLGF-------DDPQFTELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDP 287
+ ++ N+ +L P + IH+DHE N S T VGS+L DP
Sbjct: 224 DLGYTGNFLYLLDHLSETDYKPHPVLARALDKLFIIHADHEV-NCSTATVMQVGSSLVDP 282
Query: 288 YLSFAAGLNGLAGPLHGLANQEVLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGY 347
Y AAG L GP HG A++ + ++ ++G + E + F+ K +V+ G+
Sbjct: 283 YSVVAAGCAALYGPSHGGASESAI----RMLIEIG---SPENVPAFMQAVEKRERVLVGF 335
Query: 348 GHAVLRKTDPRYTCQREFALKHLPNDPLFKLVAAVYKVVP-PILTELGKVKNPWPNVDSH 406
GH V + DPR T R+ A + KL+ + +E + +N +PNVD +
Sbjct: 336 GHRVYKNVDPRSTAIRKLAEEVFEVTGRNKLLDTALTLADYARKSEFMRSRNLYPNVDFY 395
Query: 407 SGVLLQYYGLKEMNYYTVMFGVSRALGVLA--QLIWSRALGLPIERPKSL 454
SG++ Q G +++Y V+F V R +G LA + + + G+ I RP+ L
Sbjct: 396 SGLIYQAMGF-PLDFYPVLFAVPRCVGWLAHWRQMMLNSAGVKIWRPRQL 444
>UniRef50_Q1FP94 Cluster: Citrate (Si)-synthase; n=4;
Clostridiales|Rep: Citrate (Si)-synthase - Clostridium
phytofermentans ISDg
Length = 457
Score = 106 bits (254), Expect = 1e-21
Identities = 99/350 (28%), Positives = 161/350 (46%), Gaps = 28/350 (8%)
Query: 119 EGLFWLLVTGDIPTEAQAKALSKEWAARAELPAHVVT-MLNNMPGKLHPMSQFSAAVTAL 177
E + +LL+ G++PT+ Q + E R LP + ++ P K S A + L
Sbjct: 97 EEVTYLLLFGELPTKEQLEEFKVELGQRRSLPHNFCRDVIMKAPSK---DIMISLAKSIL 153
Query: 178 NSESKFAKAYSEGVHKSKYWEYVYEDTMNLIAKLPVIAATIYRNVYRD-GKGIGAIDDNK 236
S +A + + V +NLI++ P++A Y Y G + +
Sbjct: 154 TIYSYDVEAENTSIPN------VMRQCLNLISQFPMLAVYSYNAYYHSIGNSLHIHPPKE 207
Query: 237 DWSA--NYCNMLGFDDPQFTE----LMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLS 290
++S N ML D QFT ++ L L +H +H GGN S+ TT +V S+ +D Y
Sbjct: 208 EFSMAENILYMLR-PDKQFTPFEAAVLDLALVLHMEHGGGNNSSFTTRVVTSSGTDTYSV 266
Query: 291 FAAGLNGLAGPLHGLANQEVLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQ-----VVP 345
AA L L GP HG AN +V+ + L+ ++ D EE + +++ + L+ + ++
Sbjct: 267 MAAALASLKGPRHGGANIKVMQMFDDLKGKISDWKDEEAIADYLLRILRKEEFDRSGLIY 326
Query: 346 GYGHAVLRKTDPRYTCQREFALK---HLPNDPLFKLVAAVYKVVPPILTELGKV-KNPWP 401
G GHAV +DPR + F K + F+L V ++ P ++ E K+ K
Sbjct: 327 GIGHAVYSISDPRADIFKNFVGKLATEKGQEKEFELYTIVERLAPKLIGEERKIYKGVNA 386
Query: 402 NVDSHSGVLLQYYGLKEMNYYTVMFGVSRALGVLAQLIWSRALGLPIERP 451
NVD +SG + + L + YT MF V+R +G A + I RP
Sbjct: 387 NVDFYSGFVYRMLEL-PLELYTPMFAVARIVGWSAHRLEELVSAEKIIRP 435
>UniRef50_Q18RG7 Cluster: Citrate synthase; n=9; Bacteria|Rep:
Citrate synthase - Desulfitobacterium hafniense (strain
DCB-2)
Length = 455
Score = 101 bits (242), Expect = 4e-20
Identities = 87/282 (30%), Positives = 134/282 (47%), Gaps = 21/282 (7%)
Query: 200 VYEDTMNLIAKLPVIAATIYRNV--YRDGKGIGAIDDNKDWSA--NYCNMLGFDDPQFTE 255
V + + LIA P +A Y+ Y K + + S N ML + ++TE
Sbjct: 172 VLKQCIRLIAAFPALAVYCYQAYTHYHGNKSLVIHSPQPELSLAENILYMLR-PNHKYTE 230
Query: 256 L----MRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQEVL 311
L + L L +H++H GGN S+ TH+V S +D Y + AA L L GP HG AN +V+
Sbjct: 231 LEARLLDLALVLHAEHGGGNNSSFVTHVVTSTGTDTYSAVAAALGSLRGPKHGGANHKVI 290
Query: 312 VWLEKLRKQVGDNFTEEQLKEFIWKTL------KSGQVVPGYGHAVLRKTDPRYTCQREF 365
+ +++++ D E++L ++ K L +SG ++ G GHAV +DPR + +
Sbjct: 291 QMFQDIKEKISDWQDEDELSAYLDKILLKDAFDRSG-LIYGIGHAVYSISDPRAVVLKHY 349
Query: 366 ALKHLPN---DPLFKLVAAVYKVVPPILTELGKV-KNPWPNVDSHSGVLLQYYGLKEMNY 421
A K D F L A V ++ P ++ + K+ K NVD +SG + Q L +
Sbjct: 350 ASKLAAEKGLDNEFNLYAKVEELAPKVIAKHTKIYKGVSANVDFYSGFVYQMLNL-PLEM 408
Query: 422 YTVMFGVSRALGVLAQLIWSRALGLPIERPKSLSTEMLMKQV 463
+T +F +SR G A I G I RP S K V
Sbjct: 409 FTPIFALSRIAGWSAHRIEEIVNGGKIIRPAYKSVVPRQKYV 450
>UniRef50_O28929 Cluster: Citrate synthase; n=2; cellular
organisms|Rep: Citrate synthase - Archaeoglobus fulgidus
Length = 372
Score = 101 bits (242), Expect = 4e-20
Identities = 89/324 (27%), Positives = 147/324 (45%), Gaps = 27/324 (8%)
Query: 119 EGLFWLLVTGDIPTEAQAKALSKEWAARAELPAHVVTMLNNMPGKLHPMSQFSAAVTALN 178
E + +LL+ G++P + + + E A R ELP ++ +L ++P HPM A + L
Sbjct: 44 EEVAYLLLYGELPKKYELQDFKIELAERRELPPQIIGLLTHLPPYTHPMVVLRTATSYLG 103
Query: 179 SESKFAKAYSEGVHKSKYWEYVYEDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDW 238
S K + E + +LIAK P I A +R R G+ I
Sbjct: 104 SLDKKIAVRTR--------EETFNKAKDLIAKFPTIVAYYHR--IRTGRNIIPPALEFSH 153
Query: 239 SANYCNMLGFDDPQFT--ELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLN 296
+AN+ ML ++P T + + L +H++HE N S + S L+D Y A
Sbjct: 154 AANFLYMLHGEEPTKTAERALDMDLILHAEHE-LNASTFAARIAASTLADIYACVVAATG 212
Query: 297 GLAGPLHGLANQEVLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKT- 355
L GPLHG A QEV+ L ++ + + +E++ + +++G+ + G+GH V R
Sbjct: 213 TLMGPLHGGAAQEVMRMLREVA-------SPRRAEEYVKRKIEAGERIMGFGHRVYRGVM 265
Query: 356 DPRYTCQREFALKHLPNDPLFKLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYG 415
DPR R A K L + K +++ I K K PNVD +S + G
Sbjct: 266 DPRAELLRYLA-KRLAAEGSTKW----FEISEAIAKAAYKYKKLLPNVDFYSASVYANLG 320
Query: 416 LKEMNYYTVMFGVSRALGVLAQLI 439
+ + + + +F + R G A +I
Sbjct: 321 IPD-DLFVNIFAMGRISGWTAHII 343
>UniRef50_P51034 Cluster: Citrate synthase; n=351; Bacteria|Rep:
Citrate synthase - Bartonella quintana (Rochalimaea
quintana)
Length = 438
Score = 99.5 bits (237), Expect = 2e-19
Identities = 95/352 (26%), Positives = 160/352 (45%), Gaps = 41/352 (11%)
Query: 123 WLLVTGDIPTEAQAKALSKEWAARAELPAHVVTMLNNMPGKLHPMSQFSAAVTALNSESK 182
+LL+ G++PT+ + + + + HPM+ V L + S
Sbjct: 88 YLLLYGELPTKQEKIDFDRCIMQHMMVHEQFTRFFHGFRRDSHPMA---VMVACLGAMSA 144
Query: 183 FAKAYSEGVHKSKYWEYVYEDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDWSANY 242
F Y + + + + + LI+K+P +AA Y+ Y G+ ++ ++AN+
Sbjct: 145 F---YHDSIDIKDAQQRMIA-AIRLISKVPTLAAMAYK--YSIGQAFVYPRNDLSYAANF 198
Query: 243 CNMLGFD--------DPQFTELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAG 294
+M F +P + M T+H+DHE N S T LVGS+ ++P+ AAG
Sbjct: 199 LHMC-FSVPCEEYKINPVLSRAMDRIFTLHADHEQ-NASTSTVRLVGSSGANPFACIAAG 256
Query: 295 LNGLAGPLHGLANQEVLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQV--VPGYGHAVL 352
+ L GP HG AN+ L L+K+ + E++ EFI + + G+GH V
Sbjct: 257 VACLWGPAHGGANEACLKMLQKIG-------SVERIPEFIARAKDKNDPFRLMGFGHRVY 309
Query: 353 RKTDPR-----YTCQREFALKHLPNDPLFKLVAAVYKVVPPILTELGKVKNPWPNVDSHS 407
+ DPR TC ++ +DPL + A+ + E K +PNVD +S
Sbjct: 310 KNYDPRAKIMQQTCHEVLKELNIQDDPLLDIAIALENTA--LNDEYFIEKKLYPNVDFYS 367
Query: 408 GVLLQYYGLKEMNYYTVMFGVSRALGVLAQLIWSRALGLP---IERPKSLST 456
G+ L+ G +TV+F ++R++G +AQ W + P I RP+ L T
Sbjct: 368 GITLKALGF-PTEMFTVLFALARSIGWVAQ--WKEMIEDPAQKIGRPRQLYT 416
>UniRef50_P09948 Cluster: Citrate synthase; n=335; cellular
organisms|Rep: Citrate synthase - Rickettsia prowazekii
Length = 436
Score = 99.1 bits (236), Expect = 2e-19
Identities = 93/353 (26%), Positives = 169/353 (47%), Gaps = 43/353 (12%)
Query: 123 WLLVTGDIPTEAQAKALSKEWAARAELPAHVVTMLNNMPGKLHPMSQFSAAVTALNSESK 182
+L++ G++P+ Q +K+ A + + + + HPM+ AAV +L++
Sbjct: 94 YLMIYGELPSSDQYCNFTKKVAHHSLVNERLHYLFQTFCSSSHPMAIMLAAVGSLSA--- 150
Query: 183 FAKAYSEGVHKSKYWEYVYEDT-MNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDWSAN 241
Y + ++ + E YE T + +IAK+P IAA Y+ Y G+ D++ D++ N
Sbjct: 151 ---FYPDLLN---FNETDYELTAIRMIAKIPTIAAMSYK--YSIGQPFIYPDNSLDFTEN 202
Query: 242 YCNMLGFD-------DPQFTELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAG 294
+ +M+ +P + +H+DHE N S T + GS+ ++P+ + G
Sbjct: 203 FLHMMFATPCTKYKVNPIIKNALNKIFILHADHEQ-NASTSTVRIAGSSGANPFACISTG 261
Query: 295 LNGLAGPLHGLANQEVLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQV--VPGYGHAVL 352
+ L GP HG AN+ V+ + K++G + E + +++ K + G+GH V
Sbjct: 262 IASLWGPAHGGANEAVI----NMLKEIG---SSENIPKYVAKAKDKNDPFRLMGFGHRVY 314
Query: 353 RKTDPR-----YTCQREF-ALKHLPNDPLFKLVAAVYKVVPPILTELGKVKNPWPNVDSH 406
+ DPR TC+ L L N+PL ++ A+ + E + +PNVD +
Sbjct: 315 KSYDPRAAVLKETCKEVLNELGQLDNNPLLQI--AIELEALALKDEYFIERKLYPNVDFY 372
Query: 407 SGVLLQYYGLKEMNYYTVMFGVSRALGVLAQLIWSRALGLP---IERPKSLST 456
SG++ + G+ +TV+F ++R +G +AQ W P I RP+ L T
Sbjct: 373 SGIIYKAMGIPS-QMFTVLFAIARTVGWMAQ--WKEMHEDPEQKISRPRQLYT 422
>UniRef50_A0RVR8 Cluster: Citrate synthase; n=4; cellular
organisms|Rep: Citrate synthase - Cenarchaeum symbiosum
Length = 465
Score = 98.3 bits (234), Expect = 4e-19
Identities = 115/404 (28%), Positives = 179/404 (44%), Gaps = 47/404 (11%)
Query: 64 EVTVDMMYGGMRGIKGLVWETSVLDADEG-IRFRGLSIPECQQQLPKAKGGEEPLPEGLF 122
E ++D G+RGI S +D +G + +RG I + L EE +
Sbjct: 75 EPSIDTKNIGLRGIPVADTRISNIDGKQGRLIYRGYDISD----LSSKSNFEE-----VA 125
Query: 123 WLLVTGDIPTEAQAKALSKEWAARAELPAHVVTMLNNMPGKLHPMSQFSAAVTALNSESK 182
+LL+ +PT+ + A + +P + + N PM A V AL
Sbjct: 126 YLLLHDGLPTKDRLSAFNSRLVEARWIPKQMQINMGNWRKDADPMDMLQAFVAAL----- 180
Query: 183 FAKAYSEGVHKSKYWEYVYEDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDWSANY 242
A Y E E Y+ +NLI K+P I A+ +R R+G+ + D +AN+
Sbjct: 181 -AGYYDEEFANK---EASYDRAINLIGKVPTIVASWHR--IRNGEDLIDPDPALSHAANF 234
Query: 243 CNMLGFDDPQFTELMRLY---LTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLA 299
+M+ P E+ R++ L +H+DH N S V S + Y + +A + L+
Sbjct: 235 LHMMTGKVPD-KEMERIFDTCLILHADHTF-NASTFAARQVASTRAHMYSAASAAIGALS 292
Query: 300 GPLHGLANQEVLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPRY 359
G LHG AN EV+ + + D + E + +I K + GQ + G GHAV + DPR
Sbjct: 293 GELHGGANYEVM-------RMLLDMGSVEAVVPWIRKRMDDGQRIMGMGHAVYKTYDPRA 345
Query: 360 TCQREFA--LKHLPNDPLFKLVAAVYKVVPPILTELGKVKNP--WPNVDSHSGVLLQYYG 415
T +E + L P F A KV E+ K K +PNVD +S + YY
Sbjct: 346 TVLKELSRRLAAKTGQPWF---AITEKVEQATADEMKKRKGVEIYPNVDLYSASV--YYM 400
Query: 416 LK-EMNYYTVMFGVSRALGVLAQLI---WSRALGLP-IERPKSL 454
L M+ T +F +SR G A +I ++ A P + RPK++
Sbjct: 401 LDIPMDLNTPIFAISRVAGWAAHIIEEKFAEAAPKPALYRPKAV 444
>UniRef50_A1WHQ6 Cluster: Citrate synthase I; n=8;
Proteobacteria|Rep: Citrate synthase I -
Verminephrobacter eiseniae (strain EF01-2)
Length = 444
Score = 97.9 bits (233), Expect = 5e-19
Identities = 110/417 (26%), Positives = 187/417 (44%), Gaps = 56/417 (13%)
Query: 57 HGSTKVGEVTVDMMYGGMRGIKGLVWETSVLDADEGI-RFRGLSIPECQQQLPKAKGGEE 115
H ST V + + +M G+ K + + ++ DEGI R+RG SI +
Sbjct: 42 HKSTGVCTLDIGLMNTGI--CKSAI---TYVNGDEGILRYRGYSIDDLVDNCDYLD---- 92
Query: 116 PLPEGLFWLLVTGDIPTEAQAKALSKEWAARAELPAHVVTMLNNMPGKLHPMSQFSAAVT 175
+ WLL+ G++PT +Q + + + L HPM+
Sbjct: 93 -----VAWLLLNGELPTPSQKAEFQYNITYHSMVNEQMAYFLRGFRRDAHPMAVMCGMTG 147
Query: 176 ALNSESKFAKAYSE-GVHKSKYWEYVYEDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDD 234
AL+ A + E + +++ + V LIAK+P IAA Y+ Y G+ + +
Sbjct: 148 ALS-----AFYHDELDIFNAEHRKIVAH---RLIAKMPTIAAMAYK--YSIGQPLVYPRN 197
Query: 235 NKDWSANYCNML------GFD-DPQFTELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDP 287
+ D+ +N+ ML F +P + + +DHE N S T VGS+ ++P
Sbjct: 198 DLDFVSNFMQMLFAVPCEPFKLNPAGVRAFSAVMIVQADHEQ-NASTFTVRSVGSSRANP 256
Query: 288 YLSFAAGLNGLAGPLHGLANQEVLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQV--VP 345
Y AAG+ L GPLHG AN+ VL L ++G + E + I + +
Sbjct: 257 YACVAAGIASLWGPLHGGANEGVLHTL----NEIG---SIENIPAIIKRAKDKNDPYRLM 309
Query: 346 GYGHAVLRKTDPRYTCQREFALKHL-----PNDPLFKLVAAVYKVVPPILTELGKVKNPW 400
G+GH V + DPR + + + L +DPLFK+ + ++ + E + +
Sbjct: 310 GFGHRVYKTYDPRAKVLQRYCYEVLEAYGKKDDPLFKMALELERIA--LNDEFFIERKLY 367
Query: 401 PNVDSHSGVLLQYYGLKEMNYYTVMFGVSRALGVLAQLIWSRALGLP---IERPKSL 454
PNVD +SG++L+ G+ ++ +T F V+R G ++ W+ + P I RP+ L
Sbjct: 368 PNVDFYSGLILKTIGI-PLSMFTAQFAVARTAGWISH--WNEMITDPAVKIVRPRQL 421
>UniRef50_Q59939 Cluster: Citrate synthase; n=15; Bacilli|Rep:
Citrate synthase - Streptococcus mutans
Length = 372
Score = 95.1 bits (226), Expect = 4e-18
Identities = 88/299 (29%), Positives = 141/299 (47%), Gaps = 30/299 (10%)
Query: 164 LHPMSQFSAAVTALNSESKFAKAYSEGVHKSKYWEYVYEDTMNLIAKLPVIAATIYRNVY 223
LHPMS + V+ L + KA V E Y+ ++ L+AK+P I AT R
Sbjct: 89 LHPMSVLRSTVSLLGVYN--LKAEERSV------EATYDQSIQLMAKIPTIIATFARL-- 138
Query: 224 RDGKGIGAIDDNKD--WSANYCNMLGFDDPQFTELMRLY--LTIHSDHEGGNVSAHTTHL 279
+G+ I KD ++AN+ ML P E++ + L +H++HE N S +
Sbjct: 139 --RQGLSPIAPRKDLGFAANFLYMLNGRLPSELEILAMNRALVLHAEHEL-NASTFAARV 195
Query: 280 VGSALSDPYLSFAAGLNGLAGPLHGLANQEVLVWLEKLRKQVGDNFTEEQLKEFIWKTLK 339
S LSD Y + L GPLHG AN+ V L ++R + GD + ++ + L
Sbjct: 196 CASTLSDIYSCVTTAIGTLKGPLHGGANERVFDMLREIR-EYGD------VDSYLQEKLN 248
Query: 340 SGQVVPGYGHAVLRKTDPRYTCQREFALKHLPNDPLFKLVAAVYKVVPPILTELGKVKNP 399
S + + G+GH V + DPR RE A + L + Y++ + + + KN
Sbjct: 249 SKEKIMGFGHRVYQTQDPREKYLREMA-RELTKGTEHDI---WYQLSKKVEICMKQKKNL 304
Query: 400 WPNVDSHSGVLLQYYGLKEMNYYTVMFGVSRALGVLAQLIWSRALGLPIERPKSLSTEM 458
PNVD +S + G+ + + +T++F +SR G +A I + + RP+S T M
Sbjct: 305 IPNVDFYSATVYHVLGI-DSSIFTLIFAMSRVSGWIAH-IQEQQKNNKLIRPRSHYTGM 361
>UniRef50_Q93FW0 Cluster: Citrate synthase; n=4; Neorickettsia|Rep:
Citrate synthase - Ehrlichia sennetsu
Length = 398
Score = 94.7 bits (225), Expect = 5e-18
Identities = 84/318 (26%), Positives = 145/318 (45%), Gaps = 28/318 (8%)
Query: 123 WLLVTGDIPTEAQAKALSKEWAARAELPAHVVTMLNNMPGKLHPMSQFSAAVTALNSESK 182
+LL+ G +P A + + +LP V+ + + P HPM+ +A+ +L
Sbjct: 79 YLLIDGKLPDSAATREFEERIKHVPQLPECVLKNIRSFPTSAHPMAVLISALASL----- 133
Query: 183 FAKAYSEGVHKSKYWEYVYEDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDWSANY 242
A Y E K + L+A P + A IYR++ + D ++ N+
Sbjct: 134 -ASVYGEMDFNQK--------KLLLVAYTPWLIAHIYRHI--NSLEFVEPDIRLPYTENF 182
Query: 243 CNML-GFDDPQFTELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGP 301
M+ G P+ E++ +H+DH G S +V S+ + P + +A L GP
Sbjct: 183 LYMMFGEKKPKDAEILDKIFILHADH-GQTASTSVARMVVSSGASPIAACSAATASLWGP 241
Query: 302 LHGLANQEVLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPRYTC 361
LHG AN+ V LE LR V E+++ FI + + + + G+GH V + DPR
Sbjct: 242 LHGGANERV---LEMLRGIVESG---EKVENFIERVKRKEERLMGFGHRVYKNYDPRAAI 295
Query: 362 QREFALKHLPND-PLFKLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYGLKEMN 420
++ A L D P+ K + + E + +PNVD +SG++L G+
Sbjct: 296 LKQKAHDVLKADSPILKTAGELETIT--AREEYFLSRKLYPNVDFYSGIVLDALGISSC- 352
Query: 421 YYTVMFGVSRALGVLAQL 438
+T +F ++R +G +AQ+
Sbjct: 353 MFTPIFALARTVGWVAQI 370
>UniRef50_P56062 Cluster: Citrate synthase; n=43;
Epsilonproteobacteria|Rep: Citrate synthase -
Helicobacter pylori (Campylobacter pylori)
Length = 426
Score = 94.3 bits (224), Expect = 6e-18
Identities = 96/338 (28%), Positives = 158/338 (46%), Gaps = 41/338 (12%)
Query: 124 LLVTGDIPTEAQAKALSKEWAARAELPAH--VVTMLNNMPGKLHPMSQFSAAVTALNSES 181
LL+TG++P Q ++L E R H ++ M + P HPM++ S+ V+ L++
Sbjct: 88 LLLTGELPKN-QDESLEFELELRHRSFVHESLLNMFSAFPSNAHPMAKLSSGVSILST-- 144
Query: 182 KFAKAYSEGVHKSKYWEYVYED-TMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDWSA 240
YS H++ + E Y+ ++AK+P +AA YRN G I D + +
Sbjct: 145 ----LYS--THQNMHTEEDYQTMARRIVAKIPTLAAICYRNEV--GAPIIYPDIARSYVE 196
Query: 241 NYCNML-GFD--------------DPQFTELMRLYLTIHSDHEGGNVSAHTTHLVGSALS 285
N ML G+ P E LT+H+DH N S+ T V S
Sbjct: 197 NILFMLRGYPYSRLKHTTQGEVEITPLEVEAFDKILTLHADHSQ-NASSTTVRNVASTGV 255
Query: 286 DPYLSFAAGLNGLAGPLHGLANQEVLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVP 345
PY + +AG++ L G LHG AN++VL+ LE ++GD ++ + K +
Sbjct: 256 HPYAAISAGISALWGHLHGGANEKVLLQLE----EIGDVKNVDKYIARV-KDKNDNFKLM 310
Query: 346 GYGHAVLRKTDPRYTCQR----EFALKHLPNDPLFKLVAAVYKVVPPILTELGKVKNPWP 401
G+GH V + DPR + E K + D +AA + + + E +N +P
Sbjct: 311 GFGHRVYKSYDPRAKILKGLKDELHQKGVKMDERLSEIAAKVEEI-ALKDEYFIERNLYP 369
Query: 402 NVDSHSGVLLQYYGLKEMNYYTVMFGVSRALGVLAQLI 439
NVD +SG +L+ + + ++T +F + R +G AQL+
Sbjct: 370 NVDFYSGTILRALKI-PVRFFTPVFVIGRTVGWCAQLL 406
>UniRef50_Q9LXS7 Cluster: Citrate synthase 1, peroxisomal precursor;
n=11; cellular organisms|Rep: Citrate synthase 1,
peroxisomal precursor - Arabidopsis thaliana (Mouse-ear
cress)
Length = 480
Score = 93.9 bits (223), Expect = 8e-18
Identities = 98/388 (25%), Positives = 177/388 (45%), Gaps = 46/388 (11%)
Query: 85 SVLDADEGI-RFRGLSIPECQQQLPKAKGGEEPLPEGLFWLLVTGDIPTEAQAKALSKEW 143
S +D DEGI R+RG + E ++ + + +LL+ G++P++ Q
Sbjct: 107 SYIDGDEGILRYRGYPVEELAEKSTYTE---------VTYLLIYGNLPSQRQLADWEFAI 157
Query: 144 AARAELPAHVVTMLNNMPGKLHPMSQFSAAVTALNSESKFA--KAYSEGVHKSKYWEYVY 201
+ + +P V+ M+ +MP +HP+ A++AL+ A GV+KSK +
Sbjct: 158 SQNSAVPQGVLDMIQSMPNDVHPVGALVTAMSALSIFYPDANPSLMGLGVYKSK--QVRD 215
Query: 202 EDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDWSANYCNMLGF-------DDPQFT 254
+ + ++ + P IAA Y + + GK N +S N+ M+ +P+
Sbjct: 216 KQIVRVLGQAPTIAAAAY--LRKAGKPPVQPLSNLSYSENFLYMVESMGDRSYKPNPRLA 273
Query: 255 ELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQEVLVWL 314
++ + + ++HE +A HL S D Y + + G+ + GPLHG A + +
Sbjct: 274 RVLDILFILQAEHEMNCSTAAARHLSSSG-GDVYTAVSGGVGAIYGPLHGGAVEATI--- 329
Query: 315 EKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPRYTCQREFA---LKHLP 371
+ ++G T E + EFI + + G+GH + + DPR ++ A L
Sbjct: 330 -NMLSEIG---TVENIPEFIESVKNKKRRLSGFGHRIYKNYDPRGKVVKKLADEVFSILG 385
Query: 372 NDPLFKLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYGLKEMNYYTVMFGVSRA 431
DPL ++ A+ K + E + +PNVD +SG++ + G+ + +T VSR
Sbjct: 386 RDPLVEVGDALEKAA--LSDEYFVKRKLYPNVDFYSGLINRAMGIP--SSFT---AVSRI 438
Query: 432 LGVLAQLIWSRALGLP---IERPKSLST 456
G L+ W +L P I RP+ + T
Sbjct: 439 AGYLSH--WRESLDDPDTKIMRPQQVYT 464
>UniRef50_A4EA98 Cluster: Putative uncharacterized protein; n=1;
Collinsella aerofaciens ATCC 25986|Rep: Putative
uncharacterized protein - Collinsella aerofaciens ATCC
25986
Length = 472
Score = 92.3 bits (219), Expect = 2e-17
Identities = 54/186 (29%), Positives = 95/186 (51%), Gaps = 9/186 (4%)
Query: 256 LMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQEVLVWLE 315
L+ + L +H++H GGN S ++ S+ +DPY ++AA + L GP HG AN +V+ E
Sbjct: 253 LLDVMLMLHAEHGGGNNSTFACRVLSSSATDPYSAYAAAIGSLKGPRHGGANAKVVSMHE 312
Query: 316 KLRKQVGDNFTEEQLKEFIWKTLKSGQ-----VVPGYGHAVLRKTDPRYTCQREFALKHL 370
+R V + E+++ ++ K L ++ G GHAV +DPR R +A
Sbjct: 313 DIRAHVSNWEDEDEVAAYLGKILDKQAFDGTGLIYGMGHAVYTLSDPRAEVCRRYARSLA 372
Query: 371 PNDPL---FKLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYGLKEMNYYTVMFG 427
L F L+ + ++ P ++ + G K N+D ++G + + G+ E +T +F
Sbjct: 373 AKKDLGEEFALIERIERLAPQVMRDHGMTKPICANIDLYTGFIYKMLGVPE-TLFTPLFA 431
Query: 428 VSRALG 433
V+R G
Sbjct: 432 VARMAG 437
>UniRef50_Q9YB84 Cluster: Citrate synthase; n=1; Aeropyrum
pernix|Rep: Citrate synthase - Aeropyrum pernix
Length = 394
Score = 92.3 bits (219), Expect = 2e-17
Identities = 87/333 (26%), Positives = 158/333 (47%), Gaps = 26/333 (7%)
Query: 124 LLVTGDIPTEAQAKAL-SKEWAARAELPAHVVTMLNNMPGKLHPMSQFSAAVTALNSESK 182
L++ G +P + + K + SK R ++P + + ++P HPM + TAL
Sbjct: 62 LILFGRLPCDEELKEIKSKIDKYRGQIPEKLFDAMKHVP-VTHPM-YYGIYGTAL----- 114
Query: 183 FAKAYSEGVHKSKYWEYVYEDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDWSANY 242
+ Y+ + +++Y+ + L A+LPVI T + N+ G + D +KD + +
Sbjct: 115 LGQYYAPEWRFDE--DFLYDHALRLTAQLPVIFTTGW-NLAHHGTFLRP-DPSKDHAWDV 170
Query: 243 CNMLGFDDPQFTELMRLY--LTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAG 300
M+ +P E L ++ DH G N S TT ++GS LSD Y + A G+ L G
Sbjct: 171 LRMIVMREPSDIEARAFESTLVLYMDH-GFNASTFTTRVIGSTLSDLYSAVAGGIAALKG 229
Query: 301 PLHGLANQEVL-VWLEKLRKQVGDNF-TEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPR 358
PLHG AN++ + ++L+ ++K + ++E+I + L + + G+GH + + DPR
Sbjct: 230 PLHGGANEKAMEMFLDAMKKAEEKGVPLYDYIEEYIKEKLARKEKIMGFGHRIYKLHDPR 289
Query: 359 YTCQREFALKHLPNDPLFKLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYGLKE 418
+F K + K++ +V + + K N+D ++ VL G+
Sbjct: 290 TDVAAKFVAKLKDGEFWMKVLKKAEEV-------MWREKKIPANIDLYTAVLYYQLGI-P 341
Query: 419 MNYYTVMFGVSRALGVLAQLIWSRALGLPIERP 451
+ YT +F + R +G A I + L + RP
Sbjct: 342 IPMYTPIFAMGRVVGWSAHYI-EQVLNNKLIRP 373
>UniRef50_Q0LNQ6 Cluster: Citrate (Si)-synthase; n=1; Herpetosiphon
aurantiacus ATCC 23779|Rep: Citrate (Si)-synthase -
Herpetosiphon aurantiacus ATCC 23779
Length = 473
Score = 91.1 bits (216), Expect = 6e-17
Identities = 91/375 (24%), Positives = 168/375 (44%), Gaps = 39/375 (10%)
Query: 69 MMYGGMRGIKGLVWETSVLDADEG-IRFRGLSIPECQQQLPKAKGGEEPLPEGLFWLLVT 127
++Y G+ G+ + +++D +G +++RG SI + +Q E +LL+
Sbjct: 102 VVYRGLAGVTFDQSQITLIDGKQGRLQYRGYSIHDLVEQTTF---------EETAFLLLN 152
Query: 128 GDIPTEAQAKALSKEWAARAELPAHVVTMLNNMPGKLHPMSQFSAAVTALNSESKFAKAY 187
G +PT + + A E+PA ++ ++ + HP ++AL + A+
Sbjct: 153 GQLPTTTELDQFKHQLVAAREIPATILELIQLLKDG-HPTEVLRTCLSALATFD--AERL 209
Query: 188 SEGVHKSKYWEYVYEDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDWSANYCNMLG 247
V +K ++ LIA++P + A + R GK + D +AN+ ML
Sbjct: 210 DGSVTATK------ARSIRLIAQMPCLIAA--HHAIRQGKTPIQPNPTLDHAANFLYMLQ 261
Query: 248 FDDP--QFTELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGL 305
P Q +++ L +H+DH N S +V SD Y + A + AGPLHG
Sbjct: 262 GTIPSQQAQQIVNQILILHADHSA-NASTFAARVVAGTRSDWYAALTAAIAAFAGPLHGG 320
Query: 306 ANQEVLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPRYTCQREF 365
A ++V+ ++ + T E+ +++ + Q V G+GH V + DPR R+
Sbjct: 321 AIEQVIAMIQAIG-------TPERAADYVANLQANNQPVMGFGHRVYQTEDPRARHLRKA 373
Query: 366 --ALKHLPNDPLFKLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYGLKEMNYYT 423
AL ++ + ++ AV + + P + K NVD ++ V+ G+ + +
Sbjct: 374 AQALSAQSDNNYYAILEAVVQAMRPYM-----AKGIDVNVDFYASVIYHLLGI-PYDLFV 427
Query: 424 VMFGVSRALGVLAQL 438
F V R +G LAQ+
Sbjct: 428 PAFIVGRTVGWLAQI 442
>UniRef50_A6CE34 Cluster: Citrate synthase; n=1; Planctomyces maris
DSM 8797|Rep: Citrate synthase - Planctomyces maris DSM
8797
Length = 382
Score = 90.2 bits (214), Expect = 1e-16
Identities = 92/340 (27%), Positives = 152/340 (44%), Gaps = 32/340 (9%)
Query: 119 EGLFWLLVTGDIPTEAQAKALSKEWAARAELPAHVVTMLNNMPGKLHPMSQFSAAVTALN 178
E + +LL+ G++PT Q A E +P ++ L +P PM+ L
Sbjct: 54 EDVSFLLLNGELPTATQLAAYQAELKQYRSIPPELIDALKKLPVSAPPMA-------LLR 106
Query: 179 SESKFAKAYSEGVHKSKYWEYVYEDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDW 238
S + A Y + E + ++ LI+++P I A I+R R G D
Sbjct: 107 SITSLAGVYDPNAEIETF-ENRLQISIKLISQIPTIVAAIHR--VRQGLEPVEPDPELCH 163
Query: 239 SANYCNMLGFDDPQ--FTELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLN 296
+ N+ M+ + P T M L LT+H++H G N S T ++ + L D Y + +
Sbjct: 164 AGNFMYMINGEKPSEDATRAMDLILTLHAEH-GLNASTFTGRVIIATLPDIYSAVTGAIG 222
Query: 297 GLAGPLHGLANQEVLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTD 356
L G LHG AN EVL K ++G + E + ++ K ++ G+GHAV + D
Sbjct: 223 ALKGKLHGGANTEVL----KTLFEIG---SVENVAPYVKKVREAKGKFMGFGHAVYQVED 275
Query: 357 PRYTCQREFA--LKHLPNDP-LFKLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQY 413
PR +E + L +P +++ + K+V ++K NVD +S L Y
Sbjct: 276 PRAKHLKELSRRLGEETGEPKWYEMSIEMEKLV------YEEIKRNC-NVDFYSASLQHY 328
Query: 414 YGLKEMNYYTVMFGVSRALGVLAQLIWSRALGLPIERPKS 453
G+ + +T +F SR G A ++ + G I RPK+
Sbjct: 329 MGIPG-DLFTCIFAASRIAGWCAHIL-EQLDGNKIIRPKA 366
>UniRef50_Q8TU25 Cluster: Citrate (Si)-synthase; n=3;
Methanosarcina|Rep: Citrate (Si)-synthase -
Methanosarcina acetivorans
Length = 355
Score = 88.6 bits (210), Expect = 3e-16
Identities = 85/324 (26%), Positives = 145/324 (44%), Gaps = 27/324 (8%)
Query: 119 EGLFWLLVTGDIPTEAQAKALSKEWAARAELPAHVVTMLNNMPGKLHPMSQFSA-AVTAL 177
+ + +LL+ G +P E + S A + V+ ++ M F+ A+ AL
Sbjct: 31 DAVSYLLIRGRLPGEQELAEYSARLHAERRINKEVIDVIR--------MCNFNIDAMAAL 82
Query: 178 NSESKFAKAYSEGVHKSKYWEYVYEDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKD 237
+ F + ++ S E + LIA +P I AT YR +GK D +
Sbjct: 83 RTVISFISQFDPDLNDSSP-EGNMRKAIRLIAIVPTIVATYYRMA--NGKEPLPPDPSLS 139
Query: 238 WSANYCNML--GFDDPQFTELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGL 295
AN+ M+ DP E+M + ++HE N S ++ + S +SD Y + +GL
Sbjct: 140 HGANFLYMIKGSKPDPLDAEVMEKDFILSAEHEL-NASTFSSRVTASTMSDLYSAVVSGL 198
Query: 296 NGLAGPLHGLANQEVLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKT 355
L GPLHG A EV+ L+++ + E ++F+ + + + + G+GH V +
Sbjct: 199 CTLKGPLHGGARAEVMTMLDEVA-------SPENAEKFVLEKISQREKIMGFGHRVYKTY 251
Query: 356 DPRYTCQREFALKHLPND---PLFKLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQ 412
DPR ++ + K + + AV VV L E + K +PNVD +SGV+ +
Sbjct: 252 DPRGVIFKQLSKKLAESKGDMHWYTTAEAVENVVVRELVE-KRGKPIYPNVDFYSGVIYK 310
Query: 413 YYGLKEMNYYTVMFGVSRALGVLA 436
Y + T +F + R G +A
Sbjct: 311 YMEIPP-QLATSIFAIGRVSGWIA 333
>UniRef50_A0LVH0 Cluster: 2-methylcitrate synthase/citrate synthase
II; n=1; Acidothermus cellulolyticus 11B|Rep:
2-methylcitrate synthase/citrate synthase II -
Acidothermus cellulolyticus (strain ATCC 43068 / 11B)
Length = 373
Score = 87.8 bits (208), Expect = 5e-16
Identities = 86/339 (25%), Positives = 146/339 (43%), Gaps = 27/339 (7%)
Query: 108 PKAKGGEEPLPEGLFWLLVTGDIPTEAQAKALSKEWAARAELPAHVVTMLNNMPGKLHPM 167
P A+ E E + +LL GD+PT A+ A + A L V L HPM
Sbjct: 39 PAAQLAERYSIEHIAYLLWYGDLPTAAEFDAFTSRIRAAYRLDPAVADWLATTRPDTHPM 98
Query: 168 SQFSAAVTALNSESKFAKAYSEGVHKSKYWEYVYEDTMNLIAKLPVIAATIYRNVYRDGK 227
AV+ L + + L+A++P + A I R +R +
Sbjct: 99 DLLRTAVSILGATDSSTPQLDR--------DTTLAQATRLLAQMPAVVAAIQR--HRHAQ 148
Query: 228 GIGAIDDNKDWSANYCNMLGFDDPQFTELMRLY---LTIHSDHEGGNVSAHTTHLVGSAL 284
D + N+ +M FDD ++R + L ++++H G N S T +V S L
Sbjct: 149 PPIPADPGLGIAENFFHMC-FDDIPSEPMVRAFETSLILYAEH-GFNASTFTARVVTSTL 206
Query: 285 SDPYLSFAAGLNGLAGPLHGLANQEVLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVV 344
+D Y + A + L GPLHG AN+ V+ L+++ + E +++ + L+ + +
Sbjct: 207 ADLYSAITAAIGALKGPLHGGANEAVMYMLQQID-------SPEAAADWVRRALERKERI 259
Query: 345 PGYGHAVLRKTDPRYTCQREFALKHLPNDPLFKLVAAVYKVVPPILTELGKVKNPWPNVD 404
G+GH V + D R E ALK + + + A Y V + + K PN+D
Sbjct: 260 MGFGHRVYKHGDSRVPAM-EKALKTVVAERGATDLLARYHAVQDAVYQ---AKQLLPNLD 315
Query: 405 SHSGVLLQYYGLKEMNYYTVMFGVSRALGVLAQLIWSRA 443
+G G ++ +T +F ++R G +A ++ RA
Sbjct: 316 FPAGPAYYLMGF-DIPIFTPIFAMARVTGWVAHVLEQRA 353
>UniRef50_P39120 Cluster: Citrate synthase 2; n=9; cellular
organisms|Rep: Citrate synthase 2 - Bacillus subtilis
Length = 372
Score = 87.0 bits (206), Expect = 9e-16
Identities = 94/372 (25%), Positives = 166/372 (44%), Gaps = 41/372 (11%)
Query: 75 RGIKGLVWETSVLDA--DEGIRFRGLSIPECQQQLPKAKGGEEPLPEGLFWLLVTGDIPT 132
RG++G+V TS + + D+ + + G I + E E + +LL +P
Sbjct: 5 RGLEGVVATTSSVSSIIDDTLTYVGYDIDDLT---------ENASFEEIIYLLWHLRLPN 55
Query: 133 EAQAKALSKEWAARAELPAHVVTMLNNMP-GKLHPMSQFSAAVTALNSESKFAKAYSEGV 191
+ + + L ++ A A +P ++ + +HPM+ A++ L A +
Sbjct: 56 KKELEELKQQLAKEAAVPQEIIEHFKSYSLENVHPMAALRTAISLLGLLDSEADTMNP-- 113
Query: 192 HKSKYWEYVYEDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDW--SANYCNMLGFD 249
E Y + L AK+P + A R KG+ ++ +D+ + N+ L +
Sbjct: 114 ------EANYRKAIRLQAKVPGLVAAFSRI----RKGLEPVEPREDYGIAENFLYTLNGE 163
Query: 250 DPQFTEL--MRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLAN 307
+P E+ L +H+DHE N S T + + LSD Y A + L GPLHG AN
Sbjct: 164 EPSPIEVEAFNKALILHADHEL-NASTFTARVCVATLSDIYSGITAAIGALKGPLHGGAN 222
Query: 308 QEVLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPRYTCQREFAL 367
+ V+ K+ ++G+ E + +I L+ + + G+GH V + DPR +E +
Sbjct: 223 EGVM----KMLTEIGE---VENAEPYIRAKLEKKEKIMGFGHRVYKHGDPRAKHLKEMS- 274
Query: 368 KHLPNDPLFKLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYGLKEMNYYTVMFG 427
K L N + Y++ I + K PNVD +S + G+ + + +T +F
Sbjct: 275 KRLTN---LTGESKWYEMSIRIEDIVTSEKKLPPNVDFYSASVYHSLGI-DHDLFTPIFA 330
Query: 428 VSRALGVLAQLI 439
VSR G LA ++
Sbjct: 331 VSRMSGWLAHIL 342
>UniRef50_Q56063 Cluster: 2-methylcitrate synthase; n=14;
Enterobacteriaceae|Rep: 2-methylcitrate synthase -
Salmonella typhimurium
Length = 389
Score = 86.6 bits (205), Expect = 1e-15
Identities = 78/321 (24%), Positives = 140/321 (43%), Gaps = 24/321 (7%)
Query: 124 LLVTGDIPTEAQAKALSKEWAARAELPAHVVTMLNNMPGKLHPMSQFSAAVTALNSESKF 183
LL+ G +PT + A + A LPA+V T+L +P HPM V+AL
Sbjct: 64 LLIHGKLPTRDELNAYKSKLKALRGLPANVRTVLEALPAASHPMDVMRTGVSALGCTLPE 123
Query: 184 AKAYSEGVHKSKYWEYVYEDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDWSANYC 243
+ ++ + + L+A L I Y + +G+ I D+ ++
Sbjct: 124 KEGHTVSGAR--------DIADKLLASLSSILLYWYHYSH-NGERIQPETDDDSIGGHFL 174
Query: 244 NMLGFDDP--QFTELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGP 301
++L + P + + M + L ++++HE N S T+ ++ SD Y + + L GP
Sbjct: 175 HLLHGEKPTQSWEKAMHISLVLYAEHEF-NASTFTSRVIAGTGSDVYSAIIGAIGALRGP 233
Query: 302 LHGLANQEVLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPRYTC 361
HG AN+ L ++ T ++ + I K +++ +VV G+GH V DPR+
Sbjct: 234 KHGGANEVSLEIQQRYE-------TPDEAEADIRKRVENKEVVIGFGHPVYTIADPRHQV 286
Query: 362 QREFALKHLPNDPLFKLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYGLKEMNY 421
+ A + K+ Y + + T + + K +PN+D S V G+
Sbjct: 287 IKRVAKQLSEEGGSLKM----YHIADRLETVMWETKKMFPNLDWFSAVSYNMMGV-PTEM 341
Query: 422 YTVMFGVSRALGVLAQLIWSR 442
+T +F ++R G A +I R
Sbjct: 342 FTPLFVIARVTGWAAHIIEQR 362
>UniRef50_Q6MQB4 Cluster: CitZ protein; n=1; Bdellovibrio
bacteriovorus|Rep: CitZ protein - Bdellovibrio
bacteriovorus
Length = 379
Score = 85.8 bits (203), Expect = 2e-15
Identities = 84/318 (26%), Positives = 141/318 (44%), Gaps = 26/318 (8%)
Query: 119 EGLFWLLVTGDIPTEAQAKALSKEWAARAELPAHVVTMLNNMPGKLHPMSQFSAAVTALN 178
E + +LL +P + A S + L + +L +P +HPM AV+ +
Sbjct: 50 EEVTYLLWNDKLPNAQELAAFSTQLRNEMALSPDFIKVLKAIPTNVHPMGWLRTAVSLM- 108
Query: 179 SESKFAKAYSEGVHKSKYWEYVYEDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDW 238
A+ + E ++ L AK+ + + R GK A +K
Sbjct: 109 -------AHWDSDANDNGAEANLRKSVRLTAKMGTLLCAF--DAIRKGKEPVAPKADKSM 159
Query: 239 SANYCNMLGFD-DP--QFTELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGL 295
+ N MLG +P + ++M L +H+DHE N SA T + S+LSD + + + +
Sbjct: 160 AWNMMYMLGGGAEPKAEHVKVMDTCLILHADHEL-NCSAFATRVTASSLSDLHSAIVSAI 218
Query: 296 NGLAGPLHGLANQEVLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKT 355
L GPLHG AN++V++ L+K+ T E+ ++F+ L + + V G GH V +
Sbjct: 219 GALKGPLHGGANEQVILMLQKIG-------TMEKAQQFVKDALAAKEKVMGIGHRVYKNG 271
Query: 356 DPRYTCQREFALKHLPNDPLFKLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYG 415
DPR R + K L D + +Y++ I + K PNVD +S + G
Sbjct: 272 DPRARILRGMSDK-LTKD---AGIHHMYEMSTLIDDTMFNEKGLMPNVDFYSATVYFSMG 327
Query: 416 LKEMNYYTVMFGVSRALG 433
+ + +T +F SR G
Sbjct: 328 I-PTDLFTPIFAASRISG 344
>UniRef50_Q93FW6 Cluster: Citrate synthase; n=105;
Proteobacteria|Rep: Citrate synthase - Ehrlichia
chaffeensis
Length = 433
Score = 85.8 bits (203), Expect = 2e-15
Identities = 93/330 (28%), Positives = 145/330 (43%), Gaps = 38/330 (11%)
Query: 121 LFWLLVTGDIPTEAQAKALSKEWAARAELPAHVVTMLNNMPGKLHPMSQFSAAVTALNSE 180
+ +LL G +P + + + P V ++ + P HPMS A +AL
Sbjct: 103 IVYLLFYGVLPGLEDLQNFISQISQEYNPPKIVHDVIKSFPRDSHPMSILMACFSAL--- 159
Query: 181 SKFAKAYSEGVHKSKYWEYVYEDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDWSA 240
A Y H + +AK+ I A IYR Y + D +S
Sbjct: 160 ---ASCY----HNQDNSADQLKCAKLAVAKVASIIALIYR--YITNQDFVESDTKLSYSE 210
Query: 241 NYCNMLGFD--DPQFTELMRLYLTI----HSDHEGGNVSAHTTHLVGSALSDPYLSFAAG 294
N+ +M+ FD +FT+++ L I H+DHE N S T L GS+ +D + AG
Sbjct: 211 NFVHMM-FDISSYKFTQVVAKALDIIFVLHADHEQ-NASTATVRLSGSSGADLFACLVAG 268
Query: 295 LNGLAGPLHGLANQEVLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQV---VPGYGHAV 351
L GP HG AN+ V+ L + K +K+FI K +K G + G+GH V
Sbjct: 269 TATLWGPAHGGANEAVINMLMAIEK-------PSNVKQFIQK-VKDGNKSTRLMGFGHRV 320
Query: 352 LRKTDPR----YTCQREFALKHLPNDPLFKLVAAVYKVVPPILTELGKVKNPWPNVDSHS 407
+ DPR Y RE NDPL ++ + + + +N +PNVD +S
Sbjct: 321 YKNYDPRAKIMYKICREVLNNLNVNDPLLEIALELENIA--LQDSYFIDRNLYPNVDFYS 378
Query: 408 GVLLQYYGLKEMNYYTVMFGVSRALGVLAQ 437
G++L+ G+ + +T +F ++R G AQ
Sbjct: 379 GIVLKAIGI-PVRMFTTLFALARTSGWSAQ 407
>UniRef50_Q0RN64 Cluster: Citrate synthase; n=3;
Actinomycetales|Rep: Citrate synthase - Frankia alni
(strain ACN14a)
Length = 368
Score = 85.0 bits (201), Expect = 4e-15
Identities = 93/339 (27%), Positives = 151/339 (44%), Gaps = 23/339 (6%)
Query: 119 EGLFWLLVTGDIPTEAQAKALSKEWAARAELPAHVVTMLNNMPGKLHPMSQFSAAVTALN 178
E ++ L+V G++P A A + A LPA + +L PG L A+ L
Sbjct: 35 EDVWHLMVFGELPDTATRAAFAARVAPLRRLPAGLGELL---PG-LARAGGAGGALDGLR 90
Query: 179 SESKFAKAYSEGVHKSKYWEYV--YEDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNK 236
+ A A + G E +D + + A P I A ++R G A D+
Sbjct: 91 TALSLAGA-ARGTAPLYDTEEAARVDDALFVGAVTPTIVAALHR--LARGLAPVAPRDDL 147
Query: 237 DWSANYCNMLGFDDPQFTELMRL--YLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAG 294
++ANY M+ +P ++ + YL DH G N S T ++ S +D
Sbjct: 148 PFAANYLYMVTGAEPSAAQVRAIERYLICTVDH-GFNASTFTARVIASTGADLVACVVGA 206
Query: 295 LNGLAGPLHGLANQEVLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRK 354
+ L+GPLHG A L L+ ++G + E++ +I + + +G + G+GHAV R
Sbjct: 207 IGALSGPLHGGAPSRALDTLD----EIG---SPERIDPWIREHVLAGDRIMGFGHAVYRT 259
Query: 355 TDPRYTCQREFALKHLPNDPLFKLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYY 414
DPR R A + D L V + V +L EL + NV+ ++GV+++
Sbjct: 260 EDPRSRLLRAVA-EDFGGD-LVAFAVQVERRVVELLAELKPGRELHTNVEFYAGVVMELC 317
Query: 415 GLKEMNYYTVMFGVSRALGVLAQLIWSRALGLPIERPKS 453
GL + +T F V+R LG A ++ +A I RP +
Sbjct: 318 GLSR-DMFTPTFAVARTLGWTANIL-EQATDSKIIRPSA 354
>UniRef50_Q3ISY7 Cluster: Citrate (Si)-synthase; n=1; Natronomonas
pharaonis DSM 2160|Rep: Citrate (Si)-synthase -
Natronomonas pharaonis (strain DSM 2160 / ATCC 35678)
Length = 378
Score = 85.0 bits (201), Expect = 4e-15
Identities = 97/378 (25%), Positives = 167/378 (44%), Gaps = 37/378 (9%)
Query: 68 DMMYGGMRGIKGLVWETSVLDADEG-IRFRGLSIPECQQQLPKAKGGEEPLPEGLFWLLV 126
D + G+ G+ S +D DEG + +RG +I + L + EE + +LL
Sbjct: 3 DELKKGLEGVLVAESSLSYIDGDEGKLVYRGYTIDD----LARNASFEE-----VVYLLW 53
Query: 127 TGDIPTEAQAKALSKEWAARAELPAHVVTMLNNMP-GKLHPMSQFSAAVTALNSESKFAK 185
G++PT + + A L V ++ + PM+ + V++L++ A
Sbjct: 54 HGELPTADELGSFKSSMAEERHLDDGVQQLVRELAEADEEPMAALRSIVSSLSAYDPDAD 113
Query: 186 AYSEGVHKSKYWEYVYEDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDWSANYCNM 245
A E ++ + AK+P A R R+G ++ D +AN+ M
Sbjct: 114 A--EPTDEAAN----LRKGRRITAKIPTALAAFSR--IREGDDPVEPREDLDHAANFLYM 165
Query: 246 LGFDDPQ--FTELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLH 303
L ++P + + L +H+DH G N S + + S L+D + + + + L+G LH
Sbjct: 166 LNGEEPDEVLADTFDMALVLHADH-GLNASTFSAMVTSSTLADLHAAITSAVGALSGSLH 224
Query: 304 GLANQEVLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPR--YTC 361
G ANQ+V+ L +L D +E + E++ L +G+ VPG+GH V DPR
Sbjct: 225 GGANQDVMEALLEL-----DESGKEPV-EWVEDRLDAGERVPGFGHRVYNVKDPRAKILS 278
Query: 362 QREFALKHLPNDPLFKLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYGLKEMNY 421
+ AL P + + + LTE K PNVD +S G+ ++
Sbjct: 279 EESEALGEAAGTPQWHNYST---EIEEYLTE---EKGLAPNVDFYSASTYYQMGI-PVDI 331
Query: 422 YTVMFGVSRALGVLAQLI 439
YT +F +SR G +A ++
Sbjct: 332 YTPIFAMSRVGGWIAHVL 349
>UniRef50_Q1IPC3 Cluster: 2-methylcitrate synthase/citrate synthase
II; n=45; Bacteria|Rep: 2-methylcitrate synthase/citrate
synthase II - Acidobacteria bacterium (strain Ellin345)
Length = 380
Score = 84.2 bits (199), Expect = 7e-15
Identities = 96/356 (26%), Positives = 153/356 (42%), Gaps = 34/356 (9%)
Query: 87 LDADEGI-RFRGLSIPECQQQLPKAKGGEEPLPEGLFWLLVTGDIPTEAQAKALSKEWAA 145
+D D GI +RG+ I E L EE + +LL G +P + + L A
Sbjct: 25 IDGDAGILAYRGIDIHE----LADNSNFEE-----VCYLLWFGKLPNRTELQELKLNMAR 75
Query: 146 RAELPAHVVTMLNNMPGKLHPMSQFSAAVTALNSESKFAKAYSEGVHKSKYWEYVYEDTM 205
+L A V+++L P PM V+A A + K+ + +
Sbjct: 76 ERKLDASVISILRQAPKHALPMDVLRTVVSAT--------ALWDPEEKNNDHDTNVRKAI 127
Query: 206 NLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDWSANYCNMLGFDDPQFT--ELMRLYLTI 263
L +++ +I T Y + R GK + D +AN+ ML + P + + + + L +
Sbjct: 128 RLTSQMAMIV-TAYDRI-RKGKPLVEPDRTLSHAANFLLMLSGEVPSKSAEKALDIALIL 185
Query: 264 HSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQEVLVWLEKLRKQVGD 323
+DHE N S +V + LSD + + AG+ L GPLHG AN+ V L+++ K D
Sbjct: 186 QADHEL-NASTFAARVVAATLSDMHSAVTAGIGALKGPLHGGANEAVFRILDEIDKLGAD 244
Query: 324 NFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPRYTCQREFALKHLPNDPLFKLVAAVY 383
E+I L + VPG+GH V DPR T R+ + + K
Sbjct: 245 PV------EYIKGMLAQKKKVPGFGHRVYTTEDPRATHLRQMSRDLGYSSGQIKWFENSR 298
Query: 384 KVVPPILTELGKVKNPWPNVDSHSGVLLQYYGLKEMNYYTVMFGVSRALGVLAQLI 439
+ I +E K NVD +S G+ +++ +T +F VSR G A +I
Sbjct: 299 AIEEFIKSE----KKLNANVDFYSASTYHMLGI-DVDLFTPIFAVSRVSGWSAHVI 349
>UniRef50_P45858 Cluster: Citrate synthase 3; n=19; Bacillaceae|Rep:
Citrate synthase 3 - Bacillus subtilis
Length = 372
Score = 83.0 bits (196), Expect = 2e-14
Identities = 80/326 (24%), Positives = 146/326 (44%), Gaps = 26/326 (7%)
Query: 121 LFWLLVTGDIPTEAQAKALSKEWAARAELPAHVVTMLNNMPGKLHPMSQFSAAVTALNSE 180
L LL+ G +P E++ + L ++ + + LPA + +L +P HPM ++AL
Sbjct: 50 LVHLLLEGRLPEESEMETLERKINSASSLPADHLRLLELLPEDTHPMDGLRTGLSALAGY 109
Query: 181 SKFAKAYSEGVHKSKYWEYVYEDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDWSA 240
+ S +K + ++ L+ K+P + A YR + + + +SA
Sbjct: 110 DRQIDDRSPSANKERAYQ--------LLGKMPALTAASYRIINKKEPILPL--QTLSYSA 159
Query: 241 NYCNMLGFDDPQFTE--LMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGL 298
N+ M+ P E + L ++S+HE N S ++ S SD Y + + L
Sbjct: 160 NFLYMMTGKLPSSLEEQIFDRSLVLYSEHEMPN-STFAARVIASTHSDLYGALTGAVASL 218
Query: 299 AGPLHGLANQEVLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAV-LRKTDP 357
G LHG AN+ V+ L + + T ++ + LK + + G+GH V ++K DP
Sbjct: 219 KGNLHGGANEAVMYLLLEAK-------TTSDFEQLLQTKLKRKEKIMGFGHRVYMKKMDP 271
Query: 358 RYTCQREFALKHLPNDPLFKLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYGLK 417
R +E AL+ L + +Y++ + K K +PN+D ++ + G+
Sbjct: 272 RALMMKE-ALQQLCDKAGDH---RLYEMCEAGERLMEKEKGLYPNLDYYAAPVYWMLGI- 326
Query: 418 EMNYYTVMFGVSRALGVLAQLIWSRA 443
+ YT +F +R G+ A +I A
Sbjct: 327 PIPLYTPIFFSARTSGLCAHVIEQHA 352
>UniRef50_Q9XBT3 Cluster: PrpC; n=12; cellular organisms|Rep: PrpC -
Legionella pneumophila
Length = 372
Score = 82.2 bits (194), Expect = 3e-14
Identities = 88/375 (23%), Positives = 166/375 (44%), Gaps = 37/375 (9%)
Query: 72 GGMRGI-KGLVWETSVLDADEGIRFRGLSIPECQQQLPKAKGGEEPLPEGLFWLLVTGDI 130
GG+ G+ G +V A +G+ +RG SI + L + EE + +LL G++
Sbjct: 6 GGLAGVVAGQSAIATVGLAGKGLNYRGYSIND----LAEYASFEE-----VAYLLHYGEL 56
Query: 131 PTEAQAKALSKEWAARAELPAHVVTMLNNMPGKLHPMSQFSAAVTALNSESKFAKAYSEG 190
PT+ + K+ +P + T+L +P HPM A + L +
Sbjct: 57 PTQKELDVYIKKLVNLRHIPDVLKTVLKLIPKNTHPMDVLRTACSFLGT----------- 105
Query: 191 VHKSKYWEYVYEDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDWSANYCNMLGFDD 250
+ + ++ YE L+A P I Y +++ K I + + ++ +L
Sbjct: 106 IEPEENFKQQYEIADRLLALFPGIMCYWYTYHFKN-KEISGLSEENTTGGHFLALLHGRK 164
Query: 251 PQF--TELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQ 308
P T++M + L ++++HE N S + + L+D Y + + + L GPLHG AN+
Sbjct: 165 PSKIETDMMNVSLILYAEHEF-NASTFAARVTAATLADFYSAITSAIGTLRGPLHGGANE 223
Query: 309 EVLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPRYTCQREFALK 368
+ +E+ + T ++ I + L S +++ G+GH V DPR ++++ +
Sbjct: 224 AAMELIERFK-------TPDEAAIGIKQMLASKELIMGFGHRVYTTCDPRSDIIKKWSFR 276
Query: 369 HLPNDPLFKLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYGLKEMNYYTVMFGV 428
L + K +Y + I + + K +PN+D +S Y + + +T +F +
Sbjct: 277 -LGEE---KGNLLLYHISERIEEIMWQEKKLFPNLDFYSASAYHYCDI-PTHLFTPIFVM 331
Query: 429 SRALGVLAQLIWSRA 443
SR G A + RA
Sbjct: 332 SRITGWSAHVFEQRA 346
>UniRef50_P39119 Cluster: Citrate synthase 1; n=7; Bacillus|Rep:
Citrate synthase 1 - Bacillus subtilis
Length = 366
Score = 81.4 bits (192), Expect = 5e-14
Identities = 84/343 (24%), Positives = 148/343 (43%), Gaps = 27/343 (7%)
Query: 123 WLLVTGDIPTEAQAKALSKEWAARAELPAHVVTMLNNMPGKLHPMSQFSAAVTALNSESK 182
+L++ G +P+ + + + AA LP H+ ++ ++P + MS V+AL +
Sbjct: 47 YLILFGKLPSTEELQVFKDKLAAERNLPEHIERLIQSLPNNMDDMSVVRTVVSALGENT- 105
Query: 183 FAKAYSEGVHKSKYWEYVYEDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDWSANY 242
Y+ H E+ + LIA P I A YR + G+ A NY
Sbjct: 106 ----YT--FHPKT------EEAIRLIAITPSIIA--YRKRWTRGEQAIAPSSQYGHVENY 151
Query: 243 CNMLGFDDPQFTELMRL--YLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAG 300
ML + P + L Y+ + ++H G N S + + S SD + A L + G
Sbjct: 152 YYMLTGEQPSEAKKKALETYMILATEH-GMNASTFSARVTLSTESDLVSAVTAALGTMKG 210
Query: 301 PLHGLANQEVLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPRYT 360
PLHG A V LE +G+ +E + ++ + L+ G+ + G+GH V + DPR
Sbjct: 211 PLHGGAPSAVTKMLE----DIGE---KEHAEAYLKEKLEKGERLMGFGHRVYKTKDPRAE 263
Query: 361 CQREFALKHLPNDPLFKLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYGLKEMN 420
R+ A + ND L V +L + + NV+ ++ +++ +
Sbjct: 264 ALRQKAEEVAGNDRDLDLALHVEAEAIRLLEIYKPGRKLYTNVEFYAAAVMRAIDFDD-E 322
Query: 421 YYTVMFGVSRALGVLAQLIWSRALGLPIERPKSLSTEMLMKQV 463
+T F SR +G A ++ +A I RP + T + ++V
Sbjct: 323 LFTPTFSASRMVGWCAHVL-EQAENNMIFRPSAQYTGAIPEEV 364
>UniRef50_UPI0000D9A0A8 Cluster: PREDICTED: similar to citrate
synthase precursor, isoform a; n=1; Macaca mulatta|Rep:
PREDICTED: similar to citrate synthase precursor,
isoform a - Macaca mulatta
Length = 112
Score = 81.0 bits (191), Expect = 6e-14
Identities = 38/52 (73%), Positives = 42/52 (80%)
Query: 70 MYGGMRGIKGLVWETSVLDADEGIRFRGLSIPECQQQLPKAKGGEEPLPEGL 121
MYG MRGIKGLV++TSVLD EG F+G SIPE Q+ LPKAKGGE PLP GL
Sbjct: 1 MYGDMRGIKGLVYKTSVLDPHEGFCFQGFSIPEYQKLLPKAKGGEGPLPRGL 52
>UniRef50_Q8NSL1 Cluster: 2-methylcitrate synthase 2; n=29;
Bacteria|Rep: 2-methylcitrate synthase 2 -
Corynebacterium glutamicum (Brevibacterium flavum)
Length = 383
Score = 80.6 bits (190), Expect = 8e-14
Identities = 80/329 (24%), Positives = 149/329 (45%), Gaps = 32/329 (9%)
Query: 119 EGLFWLLVTGDIPTEAQAKALSKEWAARAELPAHVVTMLNNMPGKLHPMSQFSAAVTALN 178
E +F+LL G++PT Q ++ + L A ++++++++P + HPM AV+ +
Sbjct: 50 EEVFYLLWHGELPTAQQLAEFNERGRSYRSLDAGLISLIHSLPKEAHPMDVMRTAVSYMG 109
Query: 179 S-ESKFAKAYSEGVHKSKYWEYVYEDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKD 237
+ +S++ SE + K + L+A+LP++ A R R G I A D +K
Sbjct: 110 TKDSEYFTTDSEHIRKVGH---------TLLAQLPMVLAMDIRR--RKGLDIIAPDSSKS 158
Query: 238 WSANYCNML---GFDDPQFTEL----MRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLS 290
+ N +M+ G + P L ++++H N S T ++ S SD Y +
Sbjct: 159 VAENLLSMVFGTGPESPASNPADVRDFEKSLILYAEH-SFNASTFTARVITSTKSDVYSA 217
Query: 291 FAAGLNGLAGPLHGLANQEVLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHA 350
+ L GPLHG AN+ V+ + D + +I L + VV G+GH
Sbjct: 218 ITGAIGALKGPLHGGANEFVM----HTMLAIDD---PNKAAAWINNALDNKNVVMGFGHR 270
Query: 351 VLRKTDPRYTCQREFALKHLPNDPLFKLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVL 410
V ++ D R E + + L + A+Y+ + + +K PN+D +G
Sbjct: 271 VYKRGDSRVP-SMEKSFRELAARHDGEKWVAMYENMRDAMDARTGIK---PNLDFPAGPA 326
Query: 411 LQYYGLKEMNYYTVMFGVSRALGVLAQLI 439
G ++++T +F ++R G A ++
Sbjct: 327 YHLLGF-PVDFFTPLFVIARVAGWTAHIV 354
>UniRef50_Q7N2E3 Cluster: Similar to citrate synthase; n=1;
Photorhabdus luminescens subsp. laumondii|Rep: Similar
to citrate synthase - Photorhabdus luminescens subsp.
laumondii
Length = 403
Score = 79.8 bits (188), Expect = 1e-13
Identities = 58/205 (28%), Positives = 104/205 (50%), Gaps = 16/205 (7%)
Query: 255 ELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQEVLVWL 314
E++ +L +H++H G N S T V S+ +DP+ + AAG+ +GPLHG A+ V + +
Sbjct: 208 EMLNKFLILHAEH-GLNCSTATVRAVASSGADPFNAVAAGICAFSGPLHGGASGAVGLMI 266
Query: 315 EKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPRYTCQREFALKHLPNDP 374
+ + DN + + FI + ++ Q + G+GH + ++ DPR + + +K
Sbjct: 267 D----DIHDN--SKNISTFIDELVERKQRLMGFGHRIYKQPDPRASYMSDILIKQKAK-- 318
Query: 375 LFKLVAAVYKVVPPILTELGK-----VKNPWPNVDSHSGVLLQYYGLKEMNYYTVMFGVS 429
F ++++ + + +E+ K + +PN D +G+LL+ G K + T + S
Sbjct: 319 -FDVISSYVNISQELASEVSKRPYFSQRGLYPNPDLFNGLLLRRAGFKS-HMNTALLCFS 376
Query: 430 RALGVLAQLIWSRALGLPIERPKSL 454
RA G LA S PI RP+ L
Sbjct: 377 RAAGWLAHYYDSIDSKAPILRPQEL 401
>UniRef50_A6T3T1 Cluster: 2-methylcitrate synthase; n=60;
Bacteria|Rep: 2-methylcitrate synthase -
Janthinobacterium sp. (strain Marseille) (Minibacterium
massiliensis)
Length = 387
Score = 79.4 bits (187), Expect = 2e-13
Identities = 82/326 (25%), Positives = 139/326 (42%), Gaps = 24/326 (7%)
Query: 119 EGLFWLLVTGDIPTEAQAKALSKEWAARAELPAHVVTMLNNMPGKLHPMSQFSAAVTALN 178
E + LLV G +PT A+ KA + LPA+V L +P HPM V+AL
Sbjct: 57 EEIAHLLVHGKLPTAAELKAYKIKLKELRGLPANVKAALEWLPAASHPMDVMRTGVSALG 116
Query: 179 SESKFAKAYSEGVHKSKYWEYVYEDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDW 238
+ H + + + L+A L I Y + +GK I D+
Sbjct: 117 CVIP-----EKDDHNAPGARDIAD---RLMASLGSILLYWYHYSH-NGKRIEVETDDDSI 167
Query: 239 SANYCNMLGFDDPQ--FTELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLN 296
A++ ++L + P + + M L ++++HE N S T ++ SD Y + +
Sbjct: 168 GAHFLHLLHGEKPSALWEKAMHTSLILYAEHEF-NASTFTGRVIAGTGSDMYSAITGAIG 226
Query: 297 GLAGPLHGLANQEVLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTD 356
L GP HG AN+ E ++ + E +K + +++ +VV G+GH V +D
Sbjct: 227 ALRGPKHGGANEFA---FEIQKRYESPDEAEADIK----RRVENKEVVIGFGHPVYTISD 279
Query: 357 PRYTCQREFALKHLPNDPLFKLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYGL 416
PR +E A K+ + + + T + +K +PN+D S V G+
Sbjct: 280 PRNKVIKEVARTLSEEAGSLKM----FDIAERLETVMWDIKKMFPNLDWFSAVSYHMMGV 335
Query: 417 KEMNYYTVMFGVSRALGVLAQLIWSR 442
+T +F ++R G A +I R
Sbjct: 336 PTA-MFTPLFVIARTSGWAAHIIEQR 360
>UniRef50_Q8ZSU1 Cluster: Citrate synthase part 1, authentic
frameshift; n=5; Thermoproteaceae|Rep: Citrate synthase
part 1, authentic frameshift - Pyrobaculum aerophilum
Length = 342
Score = 79.4 bits (187), Expect = 2e-13
Identities = 91/357 (25%), Positives = 151/357 (42%), Gaps = 37/357 (10%)
Query: 65 VTVDMMYGGMRGIKGLVWETSVLDAD---EGIRFRGLSIPECQQQLPKAKGGEEPLPEGL 121
+T M + G+ G+ +V ET + D I +RG + E Q E +
Sbjct: 17 LTAAMYFPGLEGV--VVKETKICHIDLENSKIYYRGYDLEELAQYSTF---------EEV 65
Query: 122 FWLLVTGDIPTEAQAKALSKEWAARAELPAHVVTMLNNMPGKLHPMSQFSAAVTALNSES 181
+LL G +P A+ + E + P HV + P P+ AV+A+
Sbjct: 66 AYLLWFGKLPAGAELERFKAELMMYRKPPEHVDEAVKIAPKNAEPIDVLRTAVSAMALGE 125
Query: 182 KFAKAYSEGVHKSKYWEYVYEDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDWSAN 241
+ E E V + + A +P I A+ R R G + K +
Sbjct: 126 DLSDRSPEA-------ELVRG--LKITAAMPYIVASFDR--LRRGSQPLHPGEAKSHAEY 174
Query: 242 YCNMLGFDDPQFTELMRL--YLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLA 299
+ L + P E+ L L I+++H N SA T V S LSD Y + A + L
Sbjct: 175 FLWALRGERPGEREVRALDVMLIIYAEHSMNN-SAFTAVTVASTLSDMYAAITAAIASLK 233
Query: 300 GPLHGLANQEVLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRK-TDPR 358
GPLHG AN + K+ +++GD ++++ ++ + L G+ +PG+GH + +K DPR
Sbjct: 234 GPLHGGANVDA----AKMLEEIGD---AKRVESWVDQQLSRGRRIPGFGHRLYKKGPDPR 286
Query: 359 YTCQREFALKHLPNDPLFKLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYG 415
R+ A FK V ++ + L + K +PN D ++ V+ +Y G
Sbjct: 287 LRVLRKLARDLASEKGDFKWVELAERLEEYVTAHLSQ-KGIYPNTDLYAAVIFKYLG 342
>UniRef50_Q7W5Q6 Cluster: 2-methylcitrate synthase; n=122;
Bacteria|Rep: 2-methylcitrate synthase - Bordetella
parapertussis
Length = 400
Score = 79.0 bits (186), Expect = 2e-13
Identities = 81/327 (24%), Positives = 144/327 (44%), Gaps = 26/327 (7%)
Query: 119 EGLFWLLVTGDIPTEAQAKALSKEWAARAELPAHVVTMLNNMPGKLHPMSQFSAAVTALN 178
E + LLV G +P +A+ KA ++ A LPA + +L +P HPM AV+ L
Sbjct: 70 EEIAHLLVHGKLPNKAELKAYKEKLRALRGLPAQLQNVLECLPASSHPMDVMRTAVSVLG 129
Query: 179 SESKFAKAYSEGVHKSKYWEYVYEDTMNLIAKLPVIAATIYRNVY-RDGKGIGAIDDNKD 237
+ H + + + L+A L +A +Y Y +G+ I D+
Sbjct: 130 CVLP-----EKDDHNTPGARDIAD---RLMANLG--SALLYWYHYSHNGRVIDVQTDDDS 179
Query: 238 WSANYCNMLGFDDP--QFTELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGL 295
++ ++L P ++ M L ++++HE N S T ++ SD Y S +
Sbjct: 180 IGGHFLHLLHGAKPSDEWVRAMHTSLILYAEHEF-NASTFTGRVIAGTGSDMYSSITGAI 238
Query: 296 NGLAGPLHGLANQEVLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKT 355
L GP HG AN EV ++K + T ++ + + +++ +V+ G+GH V +
Sbjct: 239 GALRGPKHGGAN-EVAFEVQKRYE------TPDEAEADTRQRVENKEVIIGFGHPVYTVS 291
Query: 356 DPRYTCQREFALKHLPNDPLFKLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYG 415
DPR ++ A K K+ + + + T + +K +PN+D S V G
Sbjct: 292 DPRNKVIKDVAKKLSRKAGSTKM----FDIAERLETVMWDIKKMFPNLDWFSAVSYHMMG 347
Query: 416 LKEMNYYTVMFGVSRALGVLAQLIWSR 442
+ +T +F ++R G A +I R
Sbjct: 348 VPTA-MFTPLFVIARTAGWSAHIIEQR 373
>UniRef50_Q8A616 Cluster: Citrate synthase; n=16; Bacteria|Rep:
Citrate synthase - Bacteroides thetaiotaomicron
Length = 447
Score = 78.6 bits (185), Expect = 3e-13
Identities = 68/246 (27%), Positives = 116/246 (47%), Gaps = 19/246 (7%)
Query: 204 TMNLIAKLPVIAATIYRNVYRD---GKGIGAIDDNKDWSA--NYCNMLGFDDPQF-TELM 257
+++LI+K P I A Y N+ R G+ + + S N+ ML D + +
Sbjct: 169 SIDLISKFPTIIAYAY-NMLRHATFGRSLHIRHPQEKLSIAENFLYMLKKDYTELDARTL 227
Query: 258 RLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQEVLVWLEKL 317
L L + ++H GGN S T + S +D Y + AAG+ L GPLHG AN +V L
Sbjct: 228 DLLLILQAEHGGGNNSTFTVRVTSSTGTDTYSAIAAGIGSLKGPLHGGANIQVADMFHHL 287
Query: 318 RKQVGDNFTEEQLKEFIWKTL------KSGQVVPGYGHAVLRKTDPRYTCQREFALKHLP 371
++ + D + +++ + + L K+G ++ G GHAV +DPR +E A
Sbjct: 288 QENIKDWKSVDEIDTYFTRMLNKEVYNKTG-LIYGIGHAVYTISDPRALLLKELARDLAR 346
Query: 372 NDPLFKLVAAVYKVVPPILTELGKVKNPW----PNVDSHSGVLLQYYGLKEMNYYTVMFG 427
+ A + + + G+VKN N+D +SG + + GL + +T +F
Sbjct: 347 EKGKEEEFAFLELLEERAIATFGRVKNNGKTVSSNIDFYSGFVYEMIGLPQ-EIFTPLFA 405
Query: 428 VSRALG 433
++R +G
Sbjct: 406 MARIVG 411
>UniRef50_P21553 Cluster: Citrate synthase; n=9; Archaea|Rep:
Citrate synthase - Thermoplasma acidophilum
Length = 385
Score = 74.5 bits (175), Expect = 5e-12
Identities = 89/363 (24%), Positives = 159/363 (43%), Gaps = 38/363 (10%)
Query: 85 SVLDADEGI-RFRGLSIPECQQQLPKAKGGEEPLPEGLFWLLVTGDIPTEAQAKALSKEW 143
+ +D ++GI R+ G S+ + A G ++ E + +L + G++PTE + + +
Sbjct: 22 TTIDGNKGILRYGGYSVEDII-----ASGAQD---EEIQYLFLYGNLPTEQELRKYKETV 73
Query: 144 AARAELPAHVVTMLNNMPGKLHPMSQFSAAVTALN-SESKFAKAYSEGVHKSKYWEYVYE 202
++P V+ + +P + ++ AAV A+ SE+KF +++ + E
Sbjct: 74 QKGYKIPDFVINAIRQLPRESDAVAMQMAAVAAMAASETKFK--WNKDTDRDVAAE---- 127
Query: 203 DTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDWSANYCNMLGFDDPQFTEL--MRLY 260
+I ++ I +YR++ + D+ ++ ++ N E+ M
Sbjct: 128 ----MIGRMSAITVNVYRHIMNMPAELPKPSDS--YAESFLNAAFGRKATKEEIDAMNTA 181
Query: 261 LTIHSDHEGGNVSAHTTH-LVG-SALSDPYLSFAAGLNGLAGPLHGLANQEVLVWLEKLR 318
L +++DHE V A TT LV S LSD Y A L L GPLHG A + + ++++
Sbjct: 182 LILYTDHE---VPASTTAGLVAVSTLSDMYSGITAALAALKGPLHGGAAEAAIAQFDEIK 238
Query: 319 KQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPRYTCQREFALKHLPNDP-LFK 377
E+ + I + + + G+GH V + DPR + A K P + K
Sbjct: 239 DPA---MVEKWFNDNI---INGKKRLMGFGHRVYKTYDPRAKIFKGIAEKLSSKKPEVHK 292
Query: 378 LVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYGLK-EMNYYTVMFGVSRALGVLA 436
+ K+ + G K +PN D SG++ G N YT +F +SR G A
Sbjct: 293 VYEIATKLEDFGIKAFGS-KGIYPNTDYFSGIVYMSIGFPLRNNIYTALFALSRVTGWQA 351
Query: 437 QLI 439
I
Sbjct: 352 HFI 354
>UniRef50_Q8F887 Cluster: Citrate synthase; n=4; Leptospira|Rep:
Citrate synthase - Leptospira interrogans
Length = 426
Score = 73.3 bits (172), Expect = 1e-11
Identities = 85/355 (23%), Positives = 154/355 (43%), Gaps = 34/355 (9%)
Query: 123 WLLVTGDIPTEAQAKALSKEWAARAELPAHVVTMLNNMPGKLHPMSQFSAAVTALNSESK 182
+LL+ G +PTE Q K S + + + + ++ + + PGK HP++ S VT+L+ S
Sbjct: 87 YLLIYGKLPTEQQLKDFSLKLSKHSLIHEDMINLFDGFPGKGHPLAVLSVMVTSLS--SY 144
Query: 183 FAKAYSEGVHKSKYWEYVYEDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDWSANY 242
+ + Y E + K + + L+AK+ IAA Y+ + G+ D + N+
Sbjct: 145 YPEEYEESLDKG------IDHSARLLAKIRTIAAFSYKKIV--GQPFVYPLDKHPYCTNF 196
Query: 243 CNMLGFDDP--------QFTELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAG 294
ML F P ++ +++DHE NVS T ++GS ++ + S ++
Sbjct: 197 LYML-FSIPSKDYIPTEDIDRILNQLWILYADHE-QNVSNTTVQVIGSTQANLFASISSA 254
Query: 295 LNGLAGPLHG---LANQEVLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAV 351
+N L G G +A ++ + K RK V + F E+ K K + G+GH
Sbjct: 255 INALWGSREGGRQVAAVGLIEDILKSRKSVPEYF--EKFKGDSEKLFGN-----GFGHKA 307
Query: 352 LRKTDPRYTCQREFALKHLPNDPLFKLVAAVYKVVPPILTELGKV-KNPWPNVDSHSGVL 410
R + +P+ + K+ + + + +N +PN++ +S V+
Sbjct: 308 YEAKSRRAIIASKLFHDFYKKNPIGPIAEVALKIEEYMQNDEYYINQNLYPNLEFYSAVI 367
Query: 411 LQYYGLKEMNYYTVMFGVSRALGVLAQLIWSRALG-LPIERPKSL-STEMLMKQV 463
G+ + +T M + + G LA R G RPK + S EM K +
Sbjct: 368 FNSLGIPK-ELFTAMQVIGKLPGWLAHWREQRVSGNYSKARPKQIYSGEMGRKYI 421
>UniRef50_Q6L2P8 Cluster: 2-methylcitrate-synthase; n=1; Picrophilus
torridus|Rep: 2-methylcitrate-synthase - Picrophilus
torridus
Length = 365
Score = 72.9 bits (171), Expect = 2e-11
Identities = 80/336 (23%), Positives = 149/336 (44%), Gaps = 33/336 (9%)
Query: 123 WLLVTGDIPTEAQAKALSKEWAARAELPAHVVTMLNNMPGKLHPMSQFSAAVTALNSESK 182
+L++ G IP + K S + +LP + +M++ P + P+S S+ AL
Sbjct: 48 YLMLYGRIPDPKELKLFSS-YIGDGKLPERIFSMIDTFP-EGDPLSMASSVFAAL----- 100
Query: 183 FAKAYSEGVHKSKYWEYVYEDTMNLIAKLPVIAATIYRNVYRDGKGIGAID-DNKDWSAN 241
+ + W + E+ N ++ ++ ++ N+Y KG + D D +
Sbjct: 101 -------AIDNNMKWS-IDENKRNA-GRIIGLSFNVFANIYLHIKGKKLYNIDLGDPVSG 151
Query: 242 YCNMLGFDDPQFTELMRLYLTIHSDHEGGNVSAHTTH--LVGSALSDPYLSFAAGLNGLA 299
+ + D + + + ++ DHE + A TT + S LSD S ++ +N L
Sbjct: 152 FLRVTNNMDQKNVKAFEAAMILYMDHE---IPASTTAALVTASTLSDMLSSLSSAMNALK 208
Query: 300 GPLHGLANQEVLVWLEKLRKQVGDNFTEEQLKE-FIWKTLKSGQVVPGYGHAVLRKTDPR 358
GPLHG A + +LE L D + E +K F +K+ + + G+GH V + DPR
Sbjct: 209 GPLHGGAAEN--AFLEFL-----DIGSPENVKPWFNEHIIKNRERLIGFGHRVYKTYDPR 261
Query: 359 YTCQREFALKHLPNDPLFKLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYGLKE 418
RE ++ D +++ + + + K +PN D SG+L G +
Sbjct: 262 IKKFRELSMSLC--DEKNRIILDTALELERVALDYFMEKKIYPNTDFFSGLLFNELGFEH 319
Query: 419 MNYYTVMFGVSRALGVLAQLIWSRALGLPIERPKSL 454
++T +F +SR G+LA +I + RP+++
Sbjct: 320 W-FFTSLFALSRVTGILAHIIEYNENEQRLIRPRAI 354
>UniRef50_A6T5R8 Cluster: Putative citrate synthase; n=1; Klebsiella
pneumoniae subsp. pneumoniae MGH 78578|Rep: Putative
citrate synthase - Klebsiella pneumoniae subsp.
pneumoniae MGH 78578
Length = 434
Score = 72.1 bits (169), Expect = 3e-11
Identities = 85/346 (24%), Positives = 150/346 (43%), Gaps = 35/346 (10%)
Query: 123 WLLVTGDIPTEAQAKALSKEWAARAELPAHVVTMLNNMPGKLHPMSQFSAAVTALNSESK 182
++++ GD P EA + + + + M + HPM+ A V AL
Sbjct: 89 YIMLNGDAPDEASYQTFRETITRHTLVHEQIARMCSGFRRDSHPMALMCALVGAL----- 143
Query: 183 FAKAYSEGVHKSKYWEYVYEDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDWSANY 242
A+ V + ++ L++K+P IAA Y+ Y + ++ ++ N+
Sbjct: 144 --AAFYHDVLDVENPQHRALAATRLLSKMPTIAAMSYK--YTIEQPAAYPRNDLSYAGNF 199
Query: 243 CNMLGFD-------DPQFTELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGL 295
ML +P + M L +H+DH G S T GS+ ++ + AAGL
Sbjct: 200 LQMLFAIPAEKYVLNPVIEQAMNQILVLHADH-GQCASTTTVRAAGSSGANLFACVAAGL 258
Query: 296 NGLAGPLHGLANQEVLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVP--GYGHAVLR 353
L GP+HG AN+ + LE++ + +Q+ F+ + + Q G+G++ R
Sbjct: 259 ASLWGPMHGGANESSMRMLEEIE-------SVDQVPAFLRQAKRDPQAFRRLGFGNSRYR 311
Query: 354 KTDPRYTCQREFALKHLP----NDPLFKLVAAVYKVVPPILTELGKVKNPW-PNVDSHSG 408
DPR RE + + L +D L ++ A+ V LT+ V N P+VD ++
Sbjct: 312 HRDPRADILRETSHRVLAEVGMSDRLLQVAMALEDVA---LTDPYFVDNGLSPSVDFYTA 368
Query: 409 VLLQYYGLKEMNYYTVMFGVSRALGVLAQLIWSRALGLPIERPKSL 454
V+L+ L + + V+ V R +G +A L I RP+ +
Sbjct: 369 VILKAMNLPS-SMFAVVTAVGRTVGWVAHWNEMHQAPLTIYRPRQI 413
>UniRef50_A7C184 Cluster: Citrate synthase; n=1; Beggiatoa sp.
PS|Rep: Citrate synthase - Beggiatoa sp. PS
Length = 293
Score = 71.7 bits (168), Expect = 4e-11
Identities = 58/203 (28%), Positives = 94/203 (46%), Gaps = 19/203 (9%)
Query: 123 WLLVTGDIPTEAQAKALSKEWAARAELPAHVVTMLNNMPGKLHPMSQFSAAVTALNSESK 182
+LL+ G++PT+ Q + + L ++ N HPM+ V AL+S
Sbjct: 90 YLLLYGELPTQVQLENFHESIHQHTMLNEGLLRFYNGFRHNAHPMAILVGVVGALSSYYY 149
Query: 183 FAKAYSEGVHKSKYWEYVYEDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDWSANY 242
A + VH++K + LIAK+P IAA + Y G+ ++ + N+
Sbjct: 150 DAMDINNPVHRNK-------SAIRLIAKMPTIAAISHN--YLIGRPYVYPRNDLGYVENF 200
Query: 243 CNMLGFDDPQ--------FTELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAG 294
M+ F P + + + L +H+DHE N S T L GS+ + P+ AAG
Sbjct: 201 MQMM-FSVPTRPYKVSKVAAKALEILLILHADHEQ-NASTSTVRLAGSSQAHPFSCVAAG 258
Query: 295 LNGLAGPLHGLANQEVLVWLEKL 317
+ L GP HG AN+ V+ LE++
Sbjct: 259 IATLWGPAHGGANEAVIRMLEEI 281
>UniRef50_Q2R108 Cluster: Putative uncharacterized protein; n=1;
Oryza sativa (japonica cultivar-group)|Rep: Putative
uncharacterized protein - Oryza sativa subsp. japonica
(Rice)
Length = 333
Score = 71.7 bits (168), Expect = 4e-11
Identities = 31/58 (53%), Positives = 41/58 (70%)
Query: 280 VGSALSDPYLSFAAGLNGLAGPLHGLANQEVLVWLEKLRKQVGDNFTEEQLKEFIWKT 337
VGSAL PYLS A LNG AGPLHG++NQEVL+W++ + Q+G + + LKE + T
Sbjct: 121 VGSALGGPYLSLVAALNGFAGPLHGMSNQEVLLWIKPITGQIGSDIRTDLLKECVENT 178
>UniRef50_Q6CZN0 Cluster: Citrate synthase; n=14;
Proteobacteria|Rep: Citrate synthase - Erwinia
carotovora subsp. atroseptica (Pectobacterium
atrosepticum)
Length = 427
Score = 70.5 bits (165), Expect = 9e-11
Identities = 86/349 (24%), Positives = 159/349 (45%), Gaps = 36/349 (10%)
Query: 123 WLLVTGDIPT-EAQAKALSKEWAARAELPAHVVTMLNNMPGKLHPMSQFSAAVTALNSES 181
++L+ GD P+ EA AK + + + M + HPM+ A V AL
Sbjct: 88 YILLHGDAPSPEAYAK-FADNITRHTLVHEQITRMFSGFRRDSHPMALMCAVVGAL---- 142
Query: 182 KFAKAYSEGVHKSKYWEYVYEDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDWSAN 241
A+ V E+ + L++K+P +AA Y+ Y + ++ ++ N
Sbjct: 143 ---AAFYHDVLDINNAEHRELAAVRLLSKMPTLAAMCYK--YSVEQPSVYPRNSLSYTGN 197
Query: 242 YCNML------GFD-DPQFTELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAG 294
+ +ML ++ +P M L +H+DH G S GS+ ++P+ AAG
Sbjct: 198 FLHMLFSIPAEKYEVNPVLERAMNRILILHADH-GQCPSTMAVRASGSSGANPFACIAAG 256
Query: 295 LNGLAGPLHGLANQEVLVWLEKLRKQVGDNFTEEQLKEFI--WKTLKSGQVVPGYGHAVL 352
L + GPLHG AN+ + LE+++ T +++ EF+ K + G+G++V
Sbjct: 257 LASMWGPLHGGANEACMRMLEEIK-------TVDRVPEFVRRAKDRCDSFRLMGFGNSVY 309
Query: 353 RKTDPRYTCQREFALKHLPNDPL-FKLVAAVYKVVPPILTELGKVKNP-WPNVDSHSGVL 410
+ DPR R+ + L + L+ ++ +T+ ++N +P+VD ++ V+
Sbjct: 310 QHFDPRAAILRKTCYEVLNELGMEDSLLQVAMELEHIAMTDAYFLENKLYPSVDFYTSVI 369
Query: 411 LQYYGLKEMNYYTVMFGVSRALGVLAQLIWS---RALGLPIERPKSLST 456
L+ GL + +TV+ V R +G +A W + + I RP+ + T
Sbjct: 370 LKAMGLPS-SMFTVISTVGRTIGWIAH--WDEMHKQQEISIYRPRQIYT 415
>UniRef50_UPI000038E288 Cluster: hypothetical protein Faci_03000189;
n=1; Ferroplasma acidarmanus fer1|Rep: hypothetical
protein Faci_03000189 - Ferroplasma acidarmanus fer1
Length = 372
Score = 68.9 bits (161), Expect = 3e-10
Identities = 88/363 (24%), Positives = 153/363 (42%), Gaps = 41/363 (11%)
Query: 83 ETSVLDADEGI-RFRGLSIPECQQQLPKAKGGEEPLPEGLFWLLVTGDIPTEAQAKALSK 141
E + +D +GI R+RG I E E+ E + +L++ G P +++ K
Sbjct: 17 ELTFIDGQKGIMRYRGYDINEL---------AEKSSFEKVSYLMLFGKFPDDSELKNFQN 67
Query: 142 EWAARAELPAHVVTMLNNMPGKLHPMSQFSAAVTALNSESKFAKAYSEGVHKSKYWEYVY 201
+ + L ++ +L MP T L+ AKA E +K Y
Sbjct: 68 KINSHLALDDYLKDILRAMP---ETSDSLGILQTLLS-----AKASKESNYK-----YTK 114
Query: 202 EDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDN--KDWSANYCNML-GFDDPQFTELMR 258
E+ I ++ ++ N+YR G ID + ++ + G D M
Sbjct: 115 ENDGEKIPEILGSVLSMVANIYRLKSGNNIIDPEPGESYAETFLKACSGSADKNKISAMD 174
Query: 259 LYLTIHSDHEGGNVSAHTTH--LVGSALSDPYLSFAAGLNGLAGPLHGLANQEVLVWLEK 316
L ++ DHE + A TT + S LSD Y S A+ + L GPLHG A E
Sbjct: 175 SALILYMDHE---IPASTTAALVTASTLSDMYSSLASAIAALRGPLHGGA-------AEG 224
Query: 317 LRKQVGDNFTEEQLKEFIWKTLKSG-QVVPGYGHAVLRKTDPRYTCQREFALKHLPNDPL 375
+Q + E + + + +G + + G+GH V R DPR +++A +
Sbjct: 225 AYRQFLEIGEPENVNAWFENNILNGKRRLVGFGHRVYRTYDPRLKTFKKYADILSTTEEQ 284
Query: 376 FKLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYGLKEMNYYTVMFGVSRALGVL 435
K++A ++ + G K + N D ++G++ G ++ +T +FG+SR G+L
Sbjct: 285 KKILAIAKRLEEAGVKAFGS-KGIYTNTDFYAGMVFNAIGF-PVDMFTTLFGLSRISGIL 342
Query: 436 AQL 438
A +
Sbjct: 343 AHI 345
>UniRef50_A4YKX3 Cluster: Putative citrate synthase; n=1;
Bradyrhizobium sp. ORS278|Rep: Putative citrate synthase
- Bradyrhizobium sp. (strain ORS278)
Length = 371
Score = 68.9 bits (161), Expect = 3e-10
Identities = 71/257 (27%), Positives = 109/257 (42%), Gaps = 20/257 (7%)
Query: 202 EDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDWS--ANYCNMLGFDDPQFTELMRL 259
+D ++ PVIA + + +G I N D S ++ M+ D P E+ L
Sbjct: 123 DDEATIVGACPVIAGALVQRA----RGAQPIAPNPDVSHASDTLRMVRGDTPAAGEVAAL 178
Query: 260 --YLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQEVLVWLEKL 317
YL SDH G N S +V S +D + S AG L GPLHG A + VL L+ +
Sbjct: 179 ETYLVTVSDH-GMNASTFAARVVASTQADLFASITAGYCALTGPLHGGAPEPVLEMLDAI 237
Query: 318 RKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPRYTCQREFALKHLPNDPL-F 376
T E +K ++ L G+ + G+GH + + DPR + A+K L
Sbjct: 238 G-------TRENIKPWVDAALSRGERLMGFGHRIYQVRDPRADVLKG-AIKRLAGSGADL 289
Query: 377 KLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYGLKEMNYYTVMFGVSRALGVLA 436
+ V + L + + NV+ + +LL + +T +F V+RA G A
Sbjct: 290 PFASEVEAYIRQALRQKNPERVLDTNVEFFTAILLDALKIPR-QAFTPIFAVARAAGWTA 348
Query: 437 QLIWSRALGLPIERPKS 453
+ G I RP S
Sbjct: 349 HAREQQRTGRLI-RPSS 364
>UniRef50_Q89XX2 Cluster: Citrate synthase; n=8;
Alphaproteobacteria|Rep: Citrate synthase -
Bradyrhizobium japonicum
Length = 364
Score = 68.5 bits (160), Expect = 3e-10
Identities = 69/260 (26%), Positives = 108/260 (41%), Gaps = 18/260 (6%)
Query: 198 EYVYEDTMNLIAKLPVIAATIYRNVYRDGKGIGAI--DDNKDWSANYCNMLGFDDPQFTE 255
E+ E ++ PVI+ + R KG+ + D + +A+ ML P E
Sbjct: 110 EHGLEHEATIVGAFPVISGALVRRA----KGLDPVAPDPSASHAADTLRMLHGRAPATRE 165
Query: 256 LMRL--YLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQEVLVW 313
+ L YL DH G N S TT +V S +D + + AG L GPLHG A + VL
Sbjct: 166 VTALDAYLVTVCDH-GMNASTFTTRVVASTQADLFAAVTAGYCALTGPLHGGAPEPVLEM 224
Query: 314 LEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPRYTCQREFALKHLPND 373
L+ + + E+++ ++ L G+ + G+GH V R DPR + N
Sbjct: 225 LDAIG-------SRERIQPWVDAALARGERMMGFGHRVYRVRDPRADVLKTAIEALASNG 277
Query: 374 PLFKLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYGLKEMNYYTVMFGVSRALG 433
V + L + + NV+ + +LL + +T +F V+RA G
Sbjct: 278 ADLPFAGEVEAYIRAALRKKNPDRPLETNVEFFTAILLDALAIPR-QAFTPIFAVARAAG 336
Query: 434 VLAQLIWSRALGLPIERPKS 453
A + G I RP S
Sbjct: 337 WTAHAREQQRTGRLI-RPSS 355
>UniRef50_Q1AT04 Cluster: Citrate (Si)-synthase; n=4; Bacteria|Rep:
Citrate (Si)-synthase - Rubrobacter xylanophilus (strain
DSM 9941 / NBRC 16129)
Length = 391
Score = 68.5 bits (160), Expect = 3e-10
Identities = 70/257 (27%), Positives = 108/257 (42%), Gaps = 17/257 (6%)
Query: 202 EDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDWSANYCNMLGFDDP--QFTELMRL 259
+D + +A P I A +R G+ D +ANY ML + P + +
Sbjct: 131 DDALTSVAAFPTIVAACWR--LSQGREPVEPDPGLSHAANYLYMLSGEVPGEERVRALET 188
Query: 260 YLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQEVLVWLEKLRK 319
YL SDH G N S ++ S SD + + L GPLHG A L +
Sbjct: 189 YLNTVSDH-GMNASTFAARVISSTGSDLISAVVGAIGALKGPLHGGAPGPAL----DVVF 243
Query: 320 QVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPRYTCQREFALKHLPND---PLF 376
++G+ E + + + L G+ + G+GH V + DPR A + +D L+
Sbjct: 244 EIGEPGRAEGV---LRERLDRGERLMGFGHRVYKVRDPRADVLAGAAERLYASDADEELY 300
Query: 377 KLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYGLKEMNYYTVMFGVSRALGVLA 436
+L V + +L E +N NV+ ++ +LL GL +T F V R G A
Sbjct: 301 RLALEVERTALRLLEEYKPGRNLDTNVEFYTALLLHGLGL-PTGLFTPTFAVGRVAGWTA 359
Query: 437 QLIWSRALGLPIERPKS 453
+ R G I RP+S
Sbjct: 360 HCLEQRETGRLI-RPQS 375
>UniRef50_Q1AT05 Cluster: Citrate synthase; n=1; Rubrobacter
xylanophilus DSM 9941|Rep: Citrate synthase -
Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Length = 426
Score = 68.1 bits (159), Expect = 5e-10
Identities = 59/204 (28%), Positives = 89/204 (43%), Gaps = 17/204 (8%)
Query: 250 DPQFTELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQE 309
D E++ L + +DHE NVS+ T V SA + PY + AGL L G HG +
Sbjct: 220 DEGAAEILDRALVLCADHEL-NVSSFTARCVASAGATPYAAVVAGLAALGGVRHGGGTER 278
Query: 310 VLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPRYTCQREFALKH 369
V +L ++ + GD +E + L+ G+ VPG+GH + + DPR +
Sbjct: 279 VEAFLAEV-EAAGDP------REVVASRLRRGEAVPGFGHRLYPEGDPRAAALLAALAEG 331
Query: 370 LPNDPLFKLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYGLKEMNYYTVMFGVS 429
P L + ++ E PNVD VL + GL +F +
Sbjct: 332 YPGSEALGLAEGAAEAAGALVGER-------PNVDFALAVLARVLGLPP-GGALALFALG 383
Query: 430 RALGVLAQLIWSRALGLPIERPKS 453
RA+G + I A G PI RP++
Sbjct: 384 RAVGWVGHAIEQYASGAPI-RPRA 406
>UniRef50_A0LIG9 Cluster: Citrate (Si)-synthase; n=1;
Syntrophobacter fumaroxidans MPOB|Rep: Citrate
(Si)-synthase - Syntrophobacter fumaroxidans (strain DSM
10017 / MPOB)
Length = 396
Score = 64.9 bits (151), Expect = 4e-09
Identities = 99/401 (24%), Positives = 159/401 (39%), Gaps = 37/401 (9%)
Query: 64 EVTVDMMYGGMRGIKGLVWETSVLDADEGIR-FRGLSIPECQQQLPKAKGGEEPLPEGLF 122
E V G+RGI + S +D GI +RG I + L + EE
Sbjct: 2 ETDVSFKNIGLRGITVADTKISYIDGVRGILIYRGFRI----EDLAEISSFEETA----- 52
Query: 123 WLLVTGDIPTEAQAKALSKEWAARAELPAHVVTMLNNMPGKLHPMSQFSAAVTALNSESK 182
+LL+ G +P + A A LP + P + PM A+V L
Sbjct: 53 YLLLNGGLPDKEGLAAFRDALTAAGRLPDEISESFKLWPRRSDPMDIIQASVPILAMIDP 112
Query: 183 FAKAYSEGVHKSKYWEYVYEDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDWSANY 242
A S + K + +IA+LP I T +R R+G D + N+
Sbjct: 113 ELAAESREANLRK--------AIRVIARLPEIITTWHR--MRNGLQPLPHDPKLGHAGNF 162
Query: 243 CNMLGFDDPQFTELMRLY---LTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLA 299
L P+ E+ R + L + +DH + S V S + Y AG+ L+
Sbjct: 163 LWKLTGKKPE-EEMARAFEVSLILQADH-AFSASTFACREVVSTRAHLYAGVTAGVGALS 220
Query: 300 GPLHGLANQEVLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPRY 359
G LHG +N V+ + + T + + ++ L + + G GHAV + TDPR
Sbjct: 221 GILHGGSNALVM---RVMFDMIDQGMTTKDIGAWVKGKLDRREKIMGMGHAVYKTTDPRA 277
Query: 360 TCQR---EFALKHLPNDPLFKLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYGL 416
+ E + F + A+ + GK K NVD +SG+L G+
Sbjct: 278 EILKGLCENVAIKTEREEWFNFLRAIETECIREFEKRGKRKIK-ANVDFYSGLLCAMLGI 336
Query: 417 KEMNYYTVMFGVSRALGVLAQLI---WSRALGLPI-ERPKS 453
++ T +F ++ A+G + +I + A G P+ RP+S
Sbjct: 337 -PLDIMTPVFAMAIAVGWCSHIIEEKFGDAQGKPVLYRPES 376
>UniRef50_A0NXG1 Cluster: Citrate synthase; n=1; Stappia aggregata
IAM 12614|Rep: Citrate synthase - Stappia aggregata IAM
12614
Length = 389
Score = 64.1 bits (149), Expect = 8e-09
Identities = 47/184 (25%), Positives = 79/184 (42%), Gaps = 16/184 (8%)
Query: 256 LMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQEVLVWLE 315
++R L + +DHE N SA T S + + + +GL AGP HG A+ WL
Sbjct: 201 VIRAALILCADHEL-NTSAFATRCAASTRAPLHAALISGLGAFAGPRHGAASDRTTAWLS 259
Query: 316 KLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPRYTCQREFALKHLPNDPL 375
VG + ++ + L G+ +PG+GH + R DPR C + + P P
Sbjct: 260 ----DVGP---DTDIETMLSDRLSRGEPLPGFGHTIYRGPDPRAACLLDVLYRSEPAHPF 312
Query: 376 FKLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYGLKEMNYYTVMFGVSRALGVL 435
+ + + V + E PN+D + YGL + + ++F +R G +
Sbjct: 313 VQRLPGLITVAHDLFGEA-------PNIDLALAATQKTYGLPK-DAGKIIFCAARMTGWI 364
Query: 436 AQLI 439
A +
Sbjct: 365 AHAL 368
>UniRef50_P63778 Cluster: Putative citrate synthase 2; n=34;
Actinomycetales|Rep: Putative citrate synthase 2 -
Mycobacterium bovis
Length = 373
Score = 64.1 bits (149), Expect = 8e-09
Identities = 60/236 (25%), Positives = 104/236 (44%), Gaps = 13/236 (5%)
Query: 220 RNVYRDGKGIGAIDDNKDWSANYCNML-GFDDPQFTELMRLYLTIHSDHEGGNVSAHTTH 278
R +Y+ ID+ +A + G DP+ E + Y ++H G N S T
Sbjct: 128 RGIYQPAVPQRIIDECSTVTARFMTRWQGEPDPRHIEAIDAYWVSAAEH-GMNASTFTAR 186
Query: 279 LVGSALSDPYLSFAAGLNGLAGPLHGLANQEVLVWLEKLRKQVGDNFTEEQLKEFIWKTL 338
++ S +D + + + ++GPLHG A VL L+++ ++ GD + + L
Sbjct: 187 VIASTGADVAAALSGAIGAMSGPLHGGAPARVLPMLDEV-ERAGD------ARSVVKGIL 239
Query: 339 KSGQVVPGYGHAVLRKTDPRYTCQREFALKHLPNDPLFKLVAAVYKVVPPILTELGKVKN 398
G+ + G+GH V R DPR R A + L P +++ AV + L E +
Sbjct: 240 DRGEKLMGFGHRVYRAEDPRARVLRA-AAERL-GAPRYEVAVAVEQAALSELRERRPDRA 297
Query: 399 PWPNVDSHSGVLLQYYGLKEMNYYTVMFGVSRALGVLAQLIWSRALGLPIERPKSL 454
NV+ + V+L + + N MF R G A ++ + LG + RP ++
Sbjct: 298 IETNVEFWAAVVLDFARV-PANMMPAMFTCGRTAGWCAHILEQKRLG-KLVRPSAI 351
>UniRef50_A4KFK1 Cluster: Citrate synthase I gltA2; n=1;
Mycobacterium tuberculosis str. Haarlem|Rep: Citrate
synthase I gltA2 - Mycobacterium tuberculosis str.
Haarlem
Length = 410
Score = 62.9 bits (146), Expect = 2e-08
Identities = 62/248 (25%), Positives = 105/248 (42%), Gaps = 30/248 (12%)
Query: 61 KVGEVTVDMMYGGMRGIKGLVWETSVLDADEGI-RFRGLSIPECQQQLPKAKGGEEPLPE 119
K G T D+ + K + + +D D GI R+RG I + ++ +
Sbjct: 113 KTGHTTFDVGFANTAAAKSSI---TYIDGDAGILRYRGYPIDQLAEKSTFIE-------- 161
Query: 120 GLFWLLVTGDIPTEAQAKALSKEWAARAELPAHVVTMLNNMPGKLHPMSQFSAAVTALNS 179
+ +LL+ G++P Q + L + + P HPM S+ V AL++
Sbjct: 162 -VCYLLIYGELPDTDQLAQFTGRIQRHTMLHEDLKRFFDGFPRNAHPMPVLSSVVNALSA 220
Query: 180 ESKFAKAYSEGVHKSKYWEYVYEDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDWS 239
Y + + + V T+ L+AKLP IAA Y+ G+ D++
Sbjct: 221 Y------YQDALDPMDNGQ-VELSTIRLLAKLPTIAAYAYKKSV--GQPFLYPDNSLTLV 271
Query: 240 ANYCNM-LGFD------DPQFTELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFA 292
N+ + GF DP+ + + +H+DHE N S T LVGS+ ++ + S +
Sbjct: 272 ENFLRLTFGFPAEPYQADPEVVRALDMLFILHADHEQ-NCSTSTVRLVGSSRANLFTSIS 330
Query: 293 AGLNGLAG 300
G+N L G
Sbjct: 331 GGINALCG 338
>UniRef50_A6C1S1 Cluster: Type II citrate synthase; n=1;
Planctomyces maris DSM 8797|Rep: Type II citrate
synthase - Planctomyces maris DSM 8797
Length = 373
Score = 62.5 bits (145), Expect = 2e-08
Identities = 87/369 (23%), Positives = 159/369 (43%), Gaps = 39/369 (10%)
Query: 76 GIKGLV-WETSVLDADEGIRFRGLSIPECQQQLPKAKGGEEPLPEGLFWLLVTGDIPTEA 134
G+ G+V ET + EG+ +RG I E A+G E + +LL+ G++P+
Sbjct: 9 GLSGIVATETEISQIQEGLTYRGYPIDEL------ARGAA--FIE-VAYLLLHGELPSHE 59
Query: 135 QAKALSKEWAARAELPAHVVTMLNNMPGKLHPMSQFSAAVTALNSESKFAKAYSEGVHKS 194
Q LP V+ + +P + M + V+ L + F GV +S
Sbjct: 60 QLADFQTLLIETGSLPQPVMAAVEAIPPHIDMMEVIRSGVSLL---AHFDPQMEYGVFQS 116
Query: 195 KYWEYVYEDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDN--KDWSANYCNMLGFDDPQ 252
+ Y L+A LP + + YR Y +G ++ N ++ ++ ML D+P
Sbjct: 117 EVSNAQY-----LLAMLPQLIS--YR--YHQVRGSRLVEPNFHHSYAGSFWCMLKGDEPS 167
Query: 253 --FTELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQEV 310
E L I++D G + S +V S S Y + + + + G LH V
Sbjct: 168 QLEEEAFNAALIIYADF-GLSPSTFAARVVASTGSPLYSAICSAIGSINGQLHCSCGTGV 226
Query: 311 LVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPRYTCQREFALKHL 370
L+ L++ + E E++ + + G+ V G+ ++ + DPR + + ++
Sbjct: 227 ---LDVLQEAIQSGNAE----EWVCQEITKGRRVLGFENSHHKPRDPRSAVLKSYCVQLA 279
Query: 371 PNDPLFKLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYGLKEMNYYTVMFGVSR 430
D L + + I +GK++ P V+ ++ LL Y G E + +T +F VSR
Sbjct: 280 --DALGQ--NEMENAADTIEEIMGKIQKVHPRVEWYASRLLHYLGF-EPDLFTPIFSVSR 334
Query: 431 ALGVLAQLI 439
+G +A ++
Sbjct: 335 LVGWVAHIV 343
>UniRef50_A2QSJ2 Cluster: Citrate synthase; n=2; Aspergillus|Rep:
Citrate synthase - Aspergillus niger
Length = 495
Score = 61.7 bits (143), Expect = 4e-08
Identities = 80/354 (22%), Positives = 147/354 (41%), Gaps = 30/354 (8%)
Query: 124 LLVTGDIPTEAQAKALSKEWAARAELPAHVVTMLNNMPGKLHPMSQFSAAVTALNSE--S 181
LL+ G+ PT QAK+L ++ ++ L V ++ P + AA++A+ S
Sbjct: 120 LLIWGEWPTPEQAKSLQEKLSSVPVLDESVFKVIQAFPPNSSIIGMMIAALSAVQSTQMD 179
Query: 182 KFAKAYSEGVHKSKYWEYVYEDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDWSAN 241
+ ++ ++ + V ++ + L+ L +I A +Y + G+ + N
Sbjct: 180 RIPAHAAKNLYLGNP-KAVDDEIVRLMGSLSMITAAVY--CHHTGREFTPPRPELSYIEN 236
Query: 242 YCNML-------GFDDPQFTELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAG 294
+ M+ G +PQ+ + + + +DHE S S+L D + +
Sbjct: 237 FLLMMGHVESSTGLPNPQYVDRIERLWVLIADHE-MTCSTAAFLQTASSLPDVFSCMISA 295
Query: 295 LNGLAGPLHGLANQEVLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRK 354
L+ L GPLHG A +E K + + E + I + + + GYGH + R
Sbjct: 296 LSALYGPLHGGA-------IEVAYKNFEEIGSVENVAAKIERVKAGKERLYGYGHRIYRV 348
Query: 355 TDPRYTCQREF--ALK-HLPNDPLFKLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLL 411
TDPR+ R+ LK + +PL K+ V +V E + PN D + ++
Sbjct: 349 TDPRFIFIRQILDELKEEIARNPLLKVAFEVDRVASE--DEYFVTRKLRPNADLFAALVY 406
Query: 412 QYYGLKEMNYYTVMFGVSRALGVLAQLIWSRALG--LPIERPKSLSTEMLMKQV 463
G + + +SR G +A W A+ I RP + T L +++
Sbjct: 407 SAMGF-PTEFILPLSLLSRTQGFMAH--WKEAMSSTARIWRPGQIYTGHLNREM 457
>UniRef50_A0NXG0 Cluster: Type II citrate synthase; n=2;
Alphaproteobacteria|Rep: Type II citrate synthase -
Stappia aggregata IAM 12614
Length = 385
Score = 61.3 bits (142), Expect = 5e-08
Identities = 66/254 (25%), Positives = 106/254 (41%), Gaps = 16/254 (6%)
Query: 203 DTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDWSANYCNMLGFDDPQFTELMRL--Y 260
D + + LPV A +R G+ A D + + + ML + P L Y
Sbjct: 137 DAIAISGALPVFLAASHR--IATGQSPIAPDSTLETATDLLRMLSGELPPAAHAAALNRY 194
Query: 261 LTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQEVLVWLEKLRKQ 320
L DH G N S T ++GS ++ + + L+GPLHG A VL ++ + +
Sbjct: 195 LVTILDH-GLNASTFTARVIGSTQANLKQAVLGAMGALSGPLHGGAPGPVLDMIDAIGR- 252
Query: 321 VGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPRYTCQREFALKHLPND-PLFKLV 379
E +I L G+ + G+GH + R DPR + L+ L D P +L
Sbjct: 253 ------PENAAAWIGGALARGERLMGFGHRIYRTRDPRADVLKA-GLRLLGADNPKVRLA 305
Query: 380 AAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYGLKEMNYYTVMFGVSRALGVLAQLI 439
+ + L + NV+ ++ VLL G+ + +T +F V R G A ++
Sbjct: 306 EEIEQAALAALKAAKPDRPLETNVEFYTAVLLDAIGIDRI-LFTPLFAVGRTPGWCAHVL 364
Query: 440 WSRALGLPIERPKS 453
+ G I RP S
Sbjct: 365 EQQETGKLI-RPSS 377
>UniRef50_A6X0R5 Cluster: Citrate (Si)-synthase; n=1; Ochrobactrum
anthropi ATCC 49188|Rep: Citrate (Si)-synthase -
Ochrobactrum anthropi (strain ATCC 49188 / DSM 6882 /
NCTC 12168)
Length = 364
Score = 59.7 bits (138), Expect = 2e-07
Identities = 69/246 (28%), Positives = 107/246 (43%), Gaps = 22/246 (8%)
Query: 203 DTMNLIAKLPVIAA-TIYRN-VYRDGKGIGAI--DDNKDWSANYCNMLGFDDPQFTELMR 258
D +L A L ++AA ++ + R KG I D SA+ M+ P E+
Sbjct: 102 DDDDLTAALHLMAAPAVFTTAILRGQKGRRPIHPDPTLPHSADILRMMNAGMPDEAEVAG 161
Query: 259 L--YLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQEVLVWLEK 316
L YL SDH G N S +V S + S A ++ L GPLHG A VL L+
Sbjct: 162 LNTYLITVSDH-GLNASTFAARVVASTRAGLTSSLLAAISALKGPLHGGAPGPVLDMLDA 220
Query: 317 LRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPRYTCQREFALKHLP----- 371
+ + DN + ++ + G + G+GH V R DPR + ALKH+
Sbjct: 221 IGRP--DN-----AERWLESAVADGDRLMGFGHRVYRVRDPRADALKG-ALKHIEALEQG 272
Query: 372 -NDPLFKLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYGLKEMNYYTVMFGVSR 430
+L AV K +L ++ NV+ ++ +LL+ G +T +F + R
Sbjct: 273 RGKHRVELAEAVEKAAIAVLRRHKPDRSLETNVEFYTALLLEQLGFPR-EAFTCVFAMGR 331
Query: 431 ALGVLA 436
+G +A
Sbjct: 332 TMGWIA 337
>UniRef50_Q08XU9 Cluster: Citrate synthase; n=2;
Cystobacterineae|Rep: Citrate synthase - Stigmatella
aurantiaca DW4/3-1
Length = 472
Score = 58.0 bits (134), Expect = 5e-07
Identities = 56/197 (28%), Positives = 85/197 (43%), Gaps = 17/197 (8%)
Query: 261 LTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQEVLVWLEKLRKQ 320
L + +DHE NVS + S+ +D Y +A L L+GP HG + + E L +
Sbjct: 272 LVLCADHEL-NVSTFAARVAASSGADLYACVSAALAALSGPRHGGSCDRI----EALMRD 326
Query: 321 VGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPRYTCQREFALKHLPNDPLFKLVA 380
VG + + + L+ G+ +PG+GH + DPR E A K P +
Sbjct: 327 VG---RPARAASVVHERLRRGESIPGFGHRLYPAGDPRTPPLLEVAWKVRPE----RAAV 379
Query: 381 AVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYGLKEMNYYTVMFGVSRALGVLAQLIW 440
V + V + E G +P P VD L GL T +F V RA G +A +W
Sbjct: 380 RVARAVAEAMREEG---HPPPTVDFGLVALAAALGLPP-GAATALFAVGRAAGWVAH-VW 434
Query: 441 SRALGLPIERPKSLSTE 457
+ + RP++ E
Sbjct: 435 EQREQGHVLRPRARYVE 451
>UniRef50_A2QA25 Cluster: Citrate synthase; n=1; Aspergillus
niger|Rep: Citrate synthase - Aspergillus niger
Length = 472
Score = 58.0 bits (134), Expect = 5e-07
Identities = 80/332 (24%), Positives = 140/332 (42%), Gaps = 26/332 (7%)
Query: 119 EGLFWLLVTGDIPTEAQAKALSKEWA-ARAELPAHVVTMLNNMPGKLHPMSQFSAAVTA- 176
E + LL+ G +PT Q + A A +P +V ++ P PM A +T
Sbjct: 131 EEITHLLIWGSLPTPEQRLRFQRRIAEAMMVVPENVKQLVATFPRNTPPMVILCAVLTGY 190
Query: 177 LNSESKFAKAYSEGVHKSKYWEYVYEDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNK 236
L + + A++ ++ E V E + +A + IA +I + + G+ + D N
Sbjct: 191 LADQPELIPAHAGANLYNRRPEMVDEQIIRTLA-VTAIAGSI-AHCHMKGEELRMADPNL 248
Query: 237 DWSANYCNMLGFDD--PQFT-----ELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYL 289
+ N M + D P T E++ ++++DHE N ++ H V S+L+DP
Sbjct: 249 SYIENILWMGRYVDNNPAVTREKAAEILTKAWSLYADHEMTNSTSAFLH-VSSSLADPLS 307
Query: 290 SFAAGLNGLAGPLHGLANQEVLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGH 349
+ AA G LHG A + +++G + + + I K + + GYGH
Sbjct: 308 AMAACCMSGYGLLHGGAIDAAYRGM----REIGG---PQNVPKLIEKVINKECRLSGYGH 360
Query: 350 AVLRKTDPRYTCQREFALKHLPNDPLFKLVAAVYKVVPPI-----LTELGKVKNPWPNVD 404
+ ++ DPR RE L L D + + V +V I E +N N D
Sbjct: 361 RIYKQVDPRAKYVREM-LDELTRDRDIREMDPVLQVAMEIDRIASTHEYFVKRNLQANAD 419
Query: 405 SHSGVLLQYYGLKEMNYYTVMFGVSRALGVLA 436
+ + G+ + + TV+ +R GV+A
Sbjct: 420 LYGSFVYTALGI-DSQFATVLAATARVSGVMA 450
>UniRef50_Q5AVT7 Cluster: Citrate synthase; n=7; Trichocomaceae|Rep:
Citrate synthase - Emericella nidulans (Aspergillus
nidulans)
Length = 928
Score = 57.2 bits (132), Expect = 9e-07
Identities = 72/330 (21%), Positives = 127/330 (38%), Gaps = 29/330 (8%)
Query: 119 EGLFWLLVTGDIPTEAQAKALSKEWAARA-ELPAHVVTMLNNMPGKLHPMSQFSAAVTAL 177
E + LLV G PT Q + L + AA+ +P V T + ++P P++ ++
Sbjct: 94 EDMLHLLVWGSYPTPPQKEQLRSKLAAQMLAVPETVQTAVQSLPNTTPPLALILTGLSTY 153
Query: 178 NSESKFAKAYSEGVHKSKYWEYVYEDTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKD 237
S S H+ + E+ N + + A ++ V K I + D
Sbjct: 154 LSCIPETIPASTDAHQ---YRANRENVDNAVLRTVAAYAVVFGIVASHRKSIPFTPPSPD 210
Query: 238 WSANYCNML-----------GFDDPQFTELMRLYLTIHSDHEGGNVSAHTTHLVGSALSD 286
YC L G DP R + +++DH G ++ + + S+L+D
Sbjct: 211 --RTYCENLFTMAGLVDPVAGMPDPVKLSCFRRFAMLNADH-GMALTVFSALVTASSLTD 267
Query: 287 PYLSFAAGLNGLAGPLHGLANQEVLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPG 346
P + GPLH A E ++ + D TE + F+ + + + + G
Sbjct: 268 PVSCLITSVASAWGPLHFGAT-------ESAQRALADIGTEAGIPAFLDEVKQGRKRLFG 320
Query: 347 YGHAVLRKTDPRYTCQREFALKHLPNDPLFKLVAAVYKVVPPILTELGKVKNPWPNVDSH 406
YGH ++ DPR + L LP+ L KL A+ + + + +PN D +
Sbjct: 321 YGHRSYKRIDPRVRFVQSI-LHDLPSTRLLKLAEAIECAAS--ADDYFRSRGLYPNADFY 377
Query: 407 SGVLLQYYGLKEMNYYTVMFGVSRALGVLA 436
+ G E+ R +G++A
Sbjct: 378 GNFVFTGIGF-EVEMIPAAMLAQRIMGIMA 406
>UniRef50_Q98FC3 Cluster: Citrate synthase; CitZ; n=1; Mesorhizobium
loti|Rep: Citrate synthase; CitZ - Rhizobium loti
(Mesorhizobium loti)
Length = 362
Score = 55.6 bits (128), Expect = 3e-06
Identities = 66/257 (25%), Positives = 105/257 (40%), Gaps = 19/257 (7%)
Query: 203 DTMNLIAKLPVIAATIYRNVYRDGKGIGAIDDNKDWSANYCNML--GFDDPQFTELMRLY 260
D + LIA V+ + R + G+ A D +A+ ML P + + Y
Sbjct: 108 DALRLIAAPAVLTPALLR--LQRGEQPVAPDGKAAHAADMLRMLRGSVPSPALAKALDTY 165
Query: 261 LTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQEVLVWLEKLRKQ 320
L DH G N S T +V S L+ S AGL L GPLHG A V+ L+ +
Sbjct: 166 LVTVCDH-GLNASTFATRVVASTLAGLTSSVLAGLGALKGPLHGGAPGPVIEMLDAIEAH 224
Query: 321 VGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPRYTCQREFALKHLPNDPLFKLVA 380
GD ++ + G+ + G+GH + R DPR + ++ L +
Sbjct: 225 -GD------AAGWLRNEIAQGRRIMGFGHRIYRVRDPRADVLKA-VVRQLGGEGETGRRL 276
Query: 381 AVYKVVPPILTELGKVKNP----WPNVDSHSGVLLQYYGLKEMNYYTVMFGVSRALGVLA 436
A + V E+ ++ P NV+ ++ ++L+ G + V F R G +A
Sbjct: 277 AFAEEVEKTALEVLRIAKPQRSLQTNVEFYTALVLEAAGFPPQAFSNV-FAAGRVAGWIA 335
Query: 437 QLIWSRALGLPIERPKS 453
+ G I RP+S
Sbjct: 336 HAREQQTTGRLI-RPQS 351
>UniRef50_Q0RN63 Cluster: Putative citrate synthase-like protein;
n=1; Frankia alni ACN14a|Rep: Putative citrate
synthase-like protein - Frankia alni (strain ACN14a)
Length = 516
Score = 53.6 bits (123), Expect = 1e-05
Identities = 53/180 (29%), Positives = 81/180 (45%), Gaps = 18/180 (10%)
Query: 261 LTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQEVLVWLEKLRKQ 320
L + +DH+ VS + SA +DPY +AGL L GPLHG A++ L ++ +
Sbjct: 328 LGLLADHDLA-VSTFAARVAASARADPYAVVSAGLAALDGPLHGGASRLAYRLLAEVLDR 386
Query: 321 VGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPRYTCQREFALKHLP-NDPLFKLV 379
GD + + L++ Q +PG+GH + DPR AL LP +P
Sbjct: 387 -GDAVV------VVSEHLRADQRIPGFGHGLYPDGDPRARALLA-ALAALPAAEPFLAAA 438
Query: 380 AAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYGLKEMNYYTVMFGVSRALGVLAQLI 439
+ +V G+ + PNVD VL G+ V+F V+R +G LA +
Sbjct: 439 GEIARVA-------GRERALRPNVDLSLAVLTMAAGM-PAEAGEVIFAVARTVGWLAHAL 490
>UniRef50_A7HRE6 Cluster: Citrate synthase; n=1; Parvibaculum
lavamentivorans DS-1|Rep: Citrate synthase -
Parvibaculum lavamentivorans DS-1
Length = 406
Score = 50.8 bits (116), Expect = 7e-05
Identities = 42/151 (27%), Positives = 67/151 (44%), Gaps = 15/151 (9%)
Query: 254 TELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQEVLVW 313
+EL+R L + +DHE N SA T V + Y + AG+ GP HG + V
Sbjct: 216 SELIRAALVLSADHEL-NASAFTVRCVAGTGATLYAAVQAGICAAQGPRHGGLSGRV--- 271
Query: 314 LEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPRYTCQREFALKHLPND 373
E L + D + +++ + + LK VPG+GH + DPR + +D
Sbjct: 272 -ESL---LLDMSNRQDVEDAVLQRLKDNDPVPGFGHPLYPDGDPRAAALLSMVAEKYGDD 327
Query: 374 PLFKLVAAVYKVVPPILTELGKVKNPWPNVD 404
F +++V + E G +K PN+D
Sbjct: 328 ANFLRAQRIFRV----MEEAGGLK---PNID 351
>UniRef50_Q0LLM4 Cluster: Citrate synthase; n=1; Herpetosiphon
aurantiacus ATCC 23779|Rep: Citrate synthase -
Herpetosiphon aurantiacus ATCC 23779
Length = 395
Score = 50.0 bits (114), Expect = 1e-04
Identities = 37/138 (26%), Positives = 67/138 (48%), Gaps = 10/138 (7%)
Query: 251 PQFTELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQEV 310
P L+ L + +DHE NVS+ T V SA + Y +AGL L G HG ++
Sbjct: 200 PNLQPLLNAALIVSADHEL-NVSSFTARCVASAGTTLYAVVSAGLAALGGVHHGKQSELS 258
Query: 311 LVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPRYTCQREFALKHL 370
+ L++L + + + + L+ GQ +PG+GH + DPR + +
Sbjct: 259 ELLLDELLR-------SPDIYAALAQKLRLGQPIPGFGHPMYPNGDPRGKVLLDLIRQLA 311
Query: 371 P--NDPLFKLVAAVYKVV 386
P ++ + +++ AVY+++
Sbjct: 312 PQCSNDIDRIIQAVYELL 329
>UniRef50_Q1IW45 Cluster: Citrate synthase; n=1; Deinococcus
geothermalis DSM 11300|Rep: Citrate synthase -
Deinococcus geothermalis (strain DSM 11300)
Length = 402
Score = 47.6 bits (108), Expect = 7e-04
Identities = 60/205 (29%), Positives = 86/205 (41%), Gaps = 20/205 (9%)
Query: 250 DPQFTELMRLYLTIHSDHEGGNVSAHTTHLV-GSALSDPYLSFAAGLNGLAGPLHGLANQ 308
D +L+R L + +DHE NVSA T + G S P+ + AA L L GP HGLA
Sbjct: 211 DAPGADLLRRALVLLADHEL-NVSAFTARVAAGGGASLPHTTLAA-LAALQGPRHGLAGA 268
Query: 309 EVLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPRYTCQREFALK 368
L +Q + L+E TL+ PG+GH + DPR
Sbjct: 269 AAY----DLVRQALEGDAGAALRE----TLRLQAHPPGFGHRLYPGGDPRARALLAALQA 320
Query: 369 HLPNDPLFKLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYGLKEMNYYTVMFGV 428
P P V AV + + E G+ PN+D L+ G + +F +
Sbjct: 321 ARPKAP---AVQAVRALAERMREETGEA----PNLDLALAALVHALG-RAAEDTVALFAL 372
Query: 429 SRALGVLAQLIWSRALGLPIERPKS 453
R+ G LA I +R +G RP++
Sbjct: 373 GRSSGWLAHAIEAR-MGGRFIRPRA 396
>UniRef50_Q397U9 Cluster: Citrate synthase; n=4;
Burkholderiales|Rep: Citrate synthase - Burkholderia sp.
(strain 383) (Burkholderia cepacia (strain ATCC 17760/
NCIB 9086 / R18194))
Length = 429
Score = 46.4 bits (105), Expect = 0.002
Identities = 35/110 (31%), Positives = 52/110 (47%), Gaps = 9/110 (8%)
Query: 251 PQFTELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQEV 310
P EL+R+ L + +DHE N S+ T + S + GL GL+G HG A
Sbjct: 207 PAGAELIRMALVLCADHEL-NASSFTGRCIASTNASLRAVVVGGLAGLSGERHGAATARG 265
Query: 311 LVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPRYT 360
E L ++G+ E+++ E L G +PG+GHA+ D R T
Sbjct: 266 ----EALWDELGNKDVEQKMGE----RLARGDGLPGFGHALYPDGDVRAT 307
>UniRef50_Q11FP9 Cluster: Citrate synthase; n=6;
Alphaproteobacteria|Rep: Citrate synthase -
Mesorhizobium sp. (strain BNC1)
Length = 391
Score = 46.0 bits (104), Expect = 0.002
Identities = 35/111 (31%), Positives = 51/111 (45%), Gaps = 8/111 (7%)
Query: 248 FDDPQFTELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLAN 307
+D + +L R L + +DHE N S +V S + GL L+GP HG
Sbjct: 198 WDRVEAADLFRRALVLVADHEL-NASTFAARVVASTGGSLAAAVTGGLAALSGPRHGGQI 256
Query: 308 QEVLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPR 358
V E+ R Q G+ L+ FI L+ G+ +PG+GH + DPR
Sbjct: 257 PMVEALFEQAR-QAGN------LRAFIDAKLRLGERLPGFGHPLYLVADPR 300
>UniRef50_A7E4M0 Cluster: Putative uncharacterized protein; n=1;
Sclerotinia sclerotiorum 1980|Rep: Putative
uncharacterized protein - Sclerotinia sclerotiorum 1980
Length = 364
Score = 45.2 bits (102), Expect = 0.004
Identities = 52/194 (26%), Positives = 88/194 (45%), Gaps = 19/194 (9%)
Query: 255 ELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQEVLVWL 314
+L +L++ I++DHE N +A H V S L+DP A L +GPLH A L +
Sbjct: 168 QLNKLWI-IYADHEMTNSTAAFLH-VTSTLADPISGCMASLLSASGPLHAGAID--LAY- 222
Query: 315 EKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPR-YTCQR---EFALKHL 370
+ +Q+G ++E + + I Q + GYGH + + DPR Y ++ + A+K
Sbjct: 223 -RSFQQIG---SKENVAKLIADVKAKKQRLFGYGHRIYKTVDPRIYHLRKMMDDLAVKTA 278
Query: 371 PNDPLFKLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYGLKEMNYYTVMFGVSR 430
N PL + + ++ +N N D + + G E T ++R
Sbjct: 279 SN-PLLSIAMEIDRIASQ--DTYFTSRNLKANADLYGCFVFSALGF-EPEIITAAAAMAR 334
Query: 431 ALGVLAQLIWSRAL 444
+ GV+A W A+
Sbjct: 335 SSGVMAH--WREAM 346
>UniRef50_Q8RV72 Cluster: Putative citrate synthetase; n=1;
Arabidopsis thaliana|Rep: Putative citrate synthetase -
Arabidopsis thaliana (Mouse-ear cress)
Length = 83
Score = 44.0 bits (99), Expect = 0.009
Identities = 17/34 (50%), Positives = 25/34 (73%)
Query: 47 QEKIREFRKKHGSTKVGEVTVDMMYGGMRGIKGL 80
Q++ ++ + KHG VG +TVDM+ GGMRG+ GL
Sbjct: 43 QDRSKKLKLKHGKVPVGNITVDMVLGGMRGMTGL 76
>UniRef50_Q0BWL7 Cluster: Citrate synthase family protein; n=1;
Hyphomonas neptunium ATCC 15444|Rep: Citrate synthase
family protein - Hyphomonas neptunium (strain ATCC
15444)
Length = 376
Score = 43.6 bits (98), Expect = 0.011
Identities = 32/108 (29%), Positives = 50/108 (46%), Gaps = 9/108 (8%)
Query: 251 PQFTELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQEV 310
P T+L+R L + +DHE N S + S + AG L GPLHG A+Q
Sbjct: 194 PGGTDLVRRALVLVADHEL-NPSTFAARVAASTGAPLAACALAGCATLTGPLHGEASQRA 252
Query: 311 LVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPR 358
L++L++ E+ + + SG+ +P GH + + DPR
Sbjct: 253 LIYLKRA--------LEDGPETALAGLADSGEPIPATGHTLYPEGDPR 292
>UniRef50_Q89XX3 Cluster: Citrate synthase; n=3; Bradyrhizobium|Rep:
Citrate synthase - Bradyrhizobium japonicum
Length = 405
Score = 42.3 bits (95), Expect = 0.026
Identities = 31/110 (28%), Positives = 48/110 (43%), Gaps = 9/110 (8%)
Query: 249 DDPQFTELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQ 308
D+ +L+R L + +DHE N S T S + Y + AGL L GP HG A
Sbjct: 208 DNKHAPDLIRRALVLLADHEL-NASTFTARCAASTGLNLYDAVIAGLAALKGPKHGGAGV 266
Query: 309 EVLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPR 358
L Q+ + + + + + G+ G+GH V ++ DPR
Sbjct: 267 --------LASQLVKTLVDRDVAPVVRERVALGERFAGFGHGVYKRGDPR 308
>UniRef50_A0AX29 Cluster: Citrate synthase; n=7;
Burkholderiales|Rep: Citrate synthase - Burkholderia
cenocepacia (strain HI2424)
Length = 415
Score = 41.9 bits (94), Expect = 0.035
Identities = 57/209 (27%), Positives = 92/209 (44%), Gaps = 29/209 (13%)
Query: 250 DPQFTELMRLYLTIHSDHE--GGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLAN 307
D +L+R + + +DHE +A T G++L+ L+ GL L+GPLHG A+
Sbjct: 199 DSHGADLLRRAMVLVADHEITSSAFAARITASTGASLAGCLLT---GLATLSGPLHGDAS 255
Query: 308 QEVLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPRYTCQREFAL 367
V + +++ + + LK I +PG+GH + DPR + L
Sbjct: 256 GRVRAVFDDVQRLGAERVVDHHLKSAI--------PIPGFGHHLYPDGDPR----ADALL 303
Query: 368 KHLPNDPLFKLVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYGLKEMNYYTVMFG 427
L DP +L V KV T G+ P +D +L L + +F
Sbjct: 304 ARL--DPPTELAHFVDKVT----TLTGQ----RPTIDVALAMLSVQLQLPRDAAFG-LFS 352
Query: 428 VSRALGVLAQLIWSRALGLPIERPKSLST 456
++R++G+LA I +G I RP+S T
Sbjct: 353 IARSVGLLAHCIEQLRVGKVI-RPRSRYT 380
>UniRef50_Q62HJ8 Cluster: Citrate synthase family protein; n=19;
Burkholderia|Rep: Citrate synthase family protein -
Burkholderia mallei (Pseudomonas mallei)
Length = 501
Score = 41.5 bits (93), Expect = 0.046
Identities = 30/112 (26%), Positives = 52/112 (46%), Gaps = 3/112 (2%)
Query: 250 DPQFTELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQE 309
DP+ EL+R+ L + +DHE N S + S + + + A GL L+GP HG
Sbjct: 299 DPRDAELLRMALVLCADHE-LNPSTFAVRCIASTGAPLFGAIAGGLAALSGPRHGGETLR 357
Query: 310 VLVWLE-KLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPRYT 360
V L+ + + + ++ + + + +PG+GH + DPR T
Sbjct: 358 VAALLDGAAAARDLERYVAARIAAYECEP-DARTRLPGFGHPLYPDGDPRAT 408
>UniRef50_Q4STI8 Cluster: Chromosome undetermined SCAF14198, whole
genome shotgun sequence; n=2; Euteleostomi|Rep:
Chromosome undetermined SCAF14198, whole genome shotgun
sequence - Tetraodon nigroviridis (Green puffer)
Length = 535
Score = 39.5 bits (88), Expect = 0.18
Identities = 34/134 (25%), Positives = 53/134 (39%), Gaps = 11/134 (8%)
Query: 255 ELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQEVLVWL 314
+ + + L + +DH AH T + A D S +GL + G L
Sbjct: 322 QFIEMCLMVTADHGPAVSGAHNTIVCARAGKDLISSLTSGLLTIGDRFGGA--------L 373
Query: 315 EKLRKQVGDNFTEEQLK-EFIWKTLKSGQVVPGYGHAV--LRKTDPRYTCQREFALKHLP 371
+ KQ F L EF+ K K G+++ G GH V + D R ++F +H P
Sbjct: 374 DAAAKQFSKAFDSGMLPMEFVNKMKKDGKLIMGIGHRVKSINNPDMRVQILKDFVKQHFP 433
Query: 372 NDPLFKLVAAVYKV 385
+ L V K+
Sbjct: 434 STHLLDYALDVEKI 447
>UniRef50_Q13UT6 Cluster: Bifunctional--transcriptional regulator,
MerR family / Citrate synthase; n=9; Burkholderia|Rep:
Bifunctional--transcriptional regulator, MerR family /
Citrate synthase - Burkholderia xenovorans (strain
LB400)
Length = 545
Score = 39.5 bits (88), Expect = 0.18
Identities = 30/108 (27%), Positives = 49/108 (45%), Gaps = 4/108 (3%)
Query: 252 QFTELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQEVL 311
Q ++R L +DHE N S T + S + + + A GL L+GP HG V
Sbjct: 211 QQANVLRAALVACADHEL-NASTFTVRCITSTGAHLFGAVAGGLAALSGPRHGGETVRVG 269
Query: 312 VWLEKLRKQVG-DNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPR 358
LE+ + D + +L + G ++ G+GH + ++ DPR
Sbjct: 270 ALLEEASRAPDLDRYLANRLARH--EHGAHGPILSGFGHPLYQEGDPR 315
>UniRef50_Q98FC2 Cluster: Citrate synthase II; n=3;
Alphaproteobacteria|Rep: Citrate synthase II - Rhizobium
loti (Mesorhizobium loti)
Length = 379
Score = 39.1 bits (87), Expect = 0.24
Identities = 30/111 (27%), Positives = 47/111 (42%), Gaps = 9/111 (8%)
Query: 250 DPQFTELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQE 309
D + +R L + +DHE N S + S + P AGL L+GP HG A +
Sbjct: 194 DDAGADAIRRALVLLADHEL-NASTFAARVAASTGASPAACLLAGLATLSGPRHGGAGEA 252
Query: 310 VLVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPRYT 360
V+ Q+ ++ I + L + +P +GH + DPR T
Sbjct: 253 VM--------QLAEDAARHGADAAIRRWLGHDRPLPAFGHPLYPDGDPRTT 295
>UniRef50_Q2NGE5 Cluster: Putative uncharacterized protein; n=1;
Methanosphaera stadtmanae DSM 3091|Rep: Putative
uncharacterized protein - Methanosphaera stadtmanae
(strain DSM 3091)
Length = 152
Score = 38.7 bits (86), Expect = 0.32
Identities = 30/117 (25%), Positives = 52/117 (44%), Gaps = 5/117 (4%)
Query: 164 LHPMSQFSAAVTALNSESKFAKAYSEGVHKSKYWEYVYEDTMNLIAKLPVIAATIYRNVY 223
+HP S+ S + S + K SE S++ EY+ + +LI K +I Y+ +
Sbjct: 18 IHPYSEHSKTI----STDDYFKQLSENKFYSEFQEYL-SNNYSLINKEEIINFISYKPLL 72
Query: 224 RDGKGIGAIDDNKDWSANYCNMLGFDDPQFTELMRLYLTIHSDHEGGNVSAHTTHLV 280
+ + K + N +M DP+ T+L L + IHS E N +T ++
Sbjct: 73 TELIKELTVIIRKSFEKNELSMEFIQDPEITDLKYLNIYIHSSEESFNKDWNTLKII 129
>UniRef50_P53396 Cluster: ATP-citrate synthase (EC 2.3.3.8)
(ATP-citrate (pro-S-)-lyase); n=149; root|Rep:
ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate
(pro-S-)-lyase) - Homo sapiens (Human)
Length = 1101
Score = 37.9 bits (84), Expect = 0.56
Identities = 33/139 (23%), Positives = 56/139 (40%), Gaps = 12/139 (8%)
Query: 251 PQFT-ELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQE 309
P+++ + + + L + +DH AH T + A D S +GL + G
Sbjct: 883 PKYSCQFIEMCLMVTADHGPAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGA---- 938
Query: 310 VLVWLEKLRKQVGDNFTEEQLK-EFIWKTLKSGQVVPGYGHAV--LRKTDPRYTCQREFA 366
L+ K F + EF+ K K G+++ G GH V + D R +++
Sbjct: 939 ----LDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYV 994
Query: 367 LKHLPNDPLFKLVAAVYKV 385
+H P PL V K+
Sbjct: 995 RQHFPATPLLDYALEVEKI 1013
>UniRef50_A1RWT4 Cluster: Roadblock/LC7 family protein; n=1;
Thermofilum pendens Hrk 5|Rep: Roadblock/LC7 family
protein - Thermofilum pendens (strain Hrk 5)
Length = 125
Score = 37.1 bits (82), Expect = 0.99
Identities = 22/58 (37%), Positives = 30/58 (51%)
Query: 378 LVAAVYKVVPPILTELGKVKNPWPNVDSHSGVLLQYYGLKEMNYYTVMFGVSRALGVL 435
L A + +V TELGK + W V++ G + Y L E+ Y V+FG LGVL
Sbjct: 50 LTAVLSEVGNRASTELGKGEAEWITVNAPDGSGIIYTKLGEIGYMAVLFGKDTRLGVL 107
>UniRef50_Q19T76 Cluster: GltA; n=1; Anaplasma phagocytophilum|Rep:
GltA - Anaplasma phagocytophilum (Ehrlichia
phagocytophila)
Length = 116
Score = 36.7 bits (81), Expect = 1.3
Identities = 25/101 (24%), Positives = 50/101 (49%), Gaps = 12/101 (11%)
Query: 121 LFWLLVTGDIPTEAQAKALSKEWAARAELPAHVVTMLNNMPGKLHPMSQFSAAVTALNSE 180
+ +LL+ G +P+E++ + ++ +A ++P V+ ++ + P HPM+ A+ +AL ++
Sbjct: 14 IVYLLLKGTLPSESEYEEFTRILSAEYDVPKLVMDVIRSFPRDSHPMAVLIASFSALAAQ 73
Query: 181 SKFAKAYSEGVHKSKYWEYVYEDTMNLIAKLPVIAATIYRN 221
S + IAK+P I A IYR+
Sbjct: 74 YHLCNIDS------------LTGALVAIAKVPGIVACIYRH 102
>UniRef50_Q0LSA0 Cluster: Excisionase/Xis, DNA-binding; n=1;
Caulobacter sp. K31|Rep: Excisionase/Xis, DNA-binding -
Caulobacter sp. K31
Length = 389
Score = 36.3 bits (80), Expect = 1.7
Identities = 27/108 (25%), Positives = 51/108 (47%), Gaps = 8/108 (7%)
Query: 251 PQFTELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQEV 310
P + + +R L + +DHE TT+ V +A + + A + GL + G +
Sbjct: 198 PGYADAIRSCLVLAADHE----LDPTTYAVRAAANTGVTPYGAAMAGL---IAGRGRRLK 250
Query: 311 LVWLEKLRKQVGDNFTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPR 358
L E++ + V + T + +E + + G+ +PG+G + TDPR
Sbjct: 251 LARAERVARFVDELMTGDP-REAVVSRFRIGEALPGFGGELYADTDPR 297
>UniRef50_Q2K872 Cluster: Citrate synthase protein; n=3;
Rhizobiales|Rep: Citrate synthase protein - Rhizobium
etli (strain CFN 42 / ATCC 51251)
Length = 443
Score = 35.5 bits (78), Expect = 3.0
Identities = 26/67 (38%), Positives = 34/67 (50%), Gaps = 5/67 (7%)
Query: 251 PQFTELMRLYLTIHSDHE--GGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQ 308
P+ + +R L + +DHE +A T G+ALS LS GL L GPLHG A Q
Sbjct: 253 PEAGDCLRRALVLLADHELNASAFAARVTASSGAALSAAVLS---GLATLTGPLHGAAWQ 309
Query: 309 EVLVWLE 315
V +E
Sbjct: 310 SVDALIE 316
>UniRef50_Q84I41 Cluster: Citrate synthase; n=306; cellular
organisms|Rep: Citrate synthase - Bartonella
bacilliformis
Length = 112
Score = 35.1 bits (77), Expect = 4.0
Identities = 22/75 (29%), Positives = 36/75 (48%), Gaps = 7/75 (9%)
Query: 346 GYGHAVLRKTDPRY-----TCQREFALKHLPNDPLFKLVAAVYKVVPPILTELGKVKNPW 400
G+GH V + DPR TC ++ ++PLF + + + + E K +
Sbjct: 36 GFGHRVYKNYDPRAKIMQKTCHEVLKELYIQDNPLFDIAMELEHIA--LNDEYFINKKLY 93
Query: 401 PNVDSHSGVLLQYYG 415
PNVD +SG+ L+ G
Sbjct: 94 PNVDFYSGITLKALG 108
>UniRef50_O70007 Cluster: Putative citrate synthase-like protein;
n=2; Streptomyces|Rep: Putative citrate synthase-like
protein - Streptomyces coelicolor
Length = 421
Score = 34.7 bits (76), Expect = 5.3
Identities = 28/94 (29%), Positives = 44/94 (46%), Gaps = 10/94 (10%)
Query: 266 DHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQEV-LVWLEKLRKQVGDN 324
DH+ S + SA + Y + +AGL + GPLHG A + LE L ++G
Sbjct: 237 DHDLA-ASTLAVRVAASARAHAYAAVSAGLGVIEGPLHGAAGGLAHRMLLEVL--ELG-- 291
Query: 325 FTEEQLKEFIWKTLKSGQVVPGYGHAVLRKTDPR 358
+ + L++G+ +PG GH + DPR
Sbjct: 292 ----SAAPVVAEELRAGRRIPGLGHRLYPGEDPR 321
>UniRef50_A6GI60 Cluster: Putative uncharacterized protein; n=1;
Plesiocystis pacifica SIR-1|Rep: Putative
uncharacterized protein - Plesiocystis pacifica SIR-1
Length = 209
Score = 34.7 bits (76), Expect = 5.3
Identities = 26/59 (44%), Positives = 32/59 (54%), Gaps = 7/59 (11%)
Query: 249 DDPQFTELMRLY--LTIHSDHEGGNV--SAH---TTHLVGSALSDPYLSFAAGLNGLAG 300
D P F +L R+Y LT H EGG SA+ T +V +PYL+ AGL GLAG
Sbjct: 141 DAPSFRQLRRVYESLTWHMLEEGGGALPSAYFDALTQVVRLDHLEPYLAGLAGLAGLAG 199
>UniRef50_A3YDA3 Cluster: Putative C4-dicarboxylate-binding
periplasmic protein DctP; n=1; Marinomonas sp.
MED121|Rep: Putative C4-dicarboxylate-binding
periplasmic protein DctP - Marinomonas sp. MED121
Length = 344
Score = 34.7 bits (76), Expect = 5.3
Identities = 23/80 (28%), Positives = 38/80 (47%), Gaps = 2/80 (2%)
Query: 12 VELQKACPTATVLLRGLSAEQTNLKSILQEKIPKEQEKI--REFRKKHGSTKVGEVTVDM 69
++L K A+VL + Q E++ + + I +EF+K+ GEV VD+
Sbjct: 4 IQLLKQTLLASVLTAACATSQAETWKYALEEVKGDIQDIYAQEFKKRIAEKTNGEVDVDI 63
Query: 70 MYGGMRGIKGLVWETSVLDA 89
+ G G G V E + +DA
Sbjct: 64 YHYGTLGTSGDVTELTAIDA 83
>UniRef50_A2DBQ4 Cluster: Putative uncharacterized protein; n=1;
Trichomonas vaginalis G3|Rep: Putative uncharacterized
protein - Trichomonas vaginalis G3
Length = 2662
Score = 34.7 bits (76), Expect = 5.3
Identities = 19/58 (32%), Positives = 33/58 (56%)
Query: 13 ELQKACPTATVLLRGLSAEQTNLKSILQEKIPKEQEKIREFRKKHGSTKVGEVTVDMM 70
+L+K ++ GL+ Q KSIL ++I KE E+++ F +K KV +V D++
Sbjct: 1077 DLKKFIAEFKDMITGLTKSQIPNKSILTDQILKELEQLKVFAEKSKKQKVSQVANDII 1134
>UniRef50_A3I449 Cluster: Thioredoxin; n=1; Bacillus sp. B14905|Rep:
Thioredoxin - Bacillus sp. B14905
Length = 187
Score = 34.3 bits (75), Expect = 6.9
Identities = 24/63 (38%), Positives = 30/63 (47%), Gaps = 8/63 (12%)
Query: 142 EWAARA-ELPAHVVTMLNNMPGKLHPMSQFSAAVTALNSESKFAKAYSEGVHKSKYWEYV 200
+W RA EL VVT ++P K P F A AL +A+ E + YW YV
Sbjct: 121 KWGPRAPELQELVVTKRASLPDKEDPT--FEEAQKAL-----YAEIREENITNQTYWTYV 173
Query: 201 YED 203
YED
Sbjct: 174 YED 176
>UniRef50_Q9XFY7 Cluster: Putative ATP-dependent citrate lyase; n=1;
Auxenochlorella protothecoides|Rep: Putative
ATP-dependent citrate lyase - Chlorella protothecoides
(Green microalga) (Auxenochlorellaprotothecoides)
Length = 242
Score = 34.3 bits (75), Expect = 6.9
Identities = 33/109 (30%), Positives = 44/109 (40%), Gaps = 9/109 (8%)
Query: 266 DHEGGNVSAHTTHLVGSALSDPYLSFAAGLNGLAGPLHGLANQEVLVWLEKLRKQVGDNF 325
DH AH T + A D S +GL + GP G A + K+ D
Sbjct: 12 DHGPCVSGAHNTIVTARAGKDLISSLVSGLLTI-GPRFGGAIDGAAQYF----KEAVDEG 66
Query: 326 TEEQLKEFIWKTLKSGQVVPGYGHAVLRK--TDPRYTCQREFALKHLPN 372
E EF+ K K+G VPG GH + K D R + +A H P+
Sbjct: 67 WEPD--EFVEKMKKAGDQVPGIGHRIKSKDNRDKRVELLQRYARTHFPS 113
>UniRef50_Q6BIP6 Cluster: Debaryomyces hansenii chromosome G of
strain CBS767 of Debaryomyces hansenii; n=1;
Debaryomyces hansenii|Rep: Debaryomyces hansenii
chromosome G of strain CBS767 of Debaryomyces hansenii -
Debaryomyces hansenii (Yeast) (Torulaspora hansenii)
Length = 1312
Score = 34.3 bits (75), Expect = 6.9
Identities = 27/107 (25%), Positives = 42/107 (39%), Gaps = 1/107 (0%)
Query: 192 HKSKYWEYVYEDTMNLIAKLPVIAATIYR-NVYRDGKGIGAIDDNKDWSANYCNMLGFDD 250
H +Y E V D A++P+ + +YR N D KGI D+ ++C F
Sbjct: 250 HLRQYQENVRNDDRIFYAEVPIKSPGLYRINKVSDKKGISIRTYRSDFVISHCPSAEFVH 309
Query: 251 PQFTELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFAAGLNG 297
+ + Y I SD G+ + + + L F LNG
Sbjct: 310 SISPKSYQNYKCIGSDISNGDFDINLPLVSSFGVGPVVLKFETRLNG 356
>UniRef50_Q2PPA5 Cluster: Geranylgeranyl diphosphate synthase; n=3;
Gibberella fujikuroi complex|Rep: Geranylgeranyl
diphosphate synthase - Gibberella intermedia (Bulb rot
disease fungus) (Fusariumproliferatum)
Length = 392
Score = 34.3 bits (75), Expect = 6.9
Identities = 28/90 (31%), Positives = 47/90 (52%), Gaps = 11/90 (12%)
Query: 126 VTGDIPTEAQAKALSKEWAARAELPA--HVVTMLNNMPGKLHPMSQFSAAVTALNSESKF 183
VTG I T Q +A+ W A A +P+ + M+N+ G L + S + ALNSE+
Sbjct: 198 VTGTITTIFQGQAMDLWWTANAIVPSIQEYLLMVNDETGALF---RLSLELLALNSEASI 254
Query: 184 AKAYSEGVHKS-----KYWEYVYEDTMNLI 208
+ + E + + +Y++ + +D MNLI
Sbjct: 255 SDSALESLSSAVSLLGQYFQ-IRDDYMNLI 283
>UniRef50_Q6MBV1 Cluster: Putative uncharacterized protein; n=1;
Candidatus Protochlamydia amoebophila UWE25|Rep:
Putative uncharacterized protein - Protochlamydia
amoebophila (strain UWE25)
Length = 314
Score = 33.9 bits (74), Expect = 9.2
Identities = 17/77 (22%), Positives = 34/77 (44%), Gaps = 2/77 (2%)
Query: 126 VTGDIPTEAQAKALSKEWAARAELPAHVVTMLNNMPGKLHPMSQFSAAVTALNSESKFAK 185
++ IP + AK L +W ++P+ V+ N L + + A++ + S+
Sbjct: 163 LSSTIPNDQFAKKLMNKWTYERQVPSIVILSFGNQESHLKLLKNIAKAISLRFAPSRVVS 222
Query: 186 AYSEGVHKSKYWEYVYE 202
A + K K W ++E
Sbjct: 223 ALK--LEKEKQWNKLFE 237
>UniRef50_Q46UF9 Cluster: Citrate synthase; n=5; Cupriavidus|Rep:
Citrate synthase - Ralstonia eutropha (strain JMP134)
(Alcaligenes eutrophus)
Length = 259
Score = 33.9 bits (74), Expect = 9.2
Identities = 43/152 (28%), Positives = 70/152 (46%), Gaps = 11/152 (7%)
Query: 292 AAGLNGLAGPLHGLANQEVLVWLEKLRKQVGDNFTEEQLKE----FIWKTLKSGQVVPGY 347
A GL G AG + Q L + +++ D+ T+EQL E I + +S Q V G
Sbjct: 90 ATGLLG-AGSVFLGPMQNATEMLNEGTRELSDDATDEQLLETARALIKRYKESRQQVYGV 148
Query: 348 GHAVLRKTDPRYTCQREFALKHLPNDPLFKLVAAVYKVVPPILTELGKVKNPWPNVDSHS 407
GH + DPR RE + ++ ++L+ A+ +V L + K K P NV
Sbjct: 149 GHPIHVDGDPRVPALRELSRQNGYYGLHWRLMEAIVEV----LVKEQKRKLPM-NVVGAI 203
Query: 408 GVLLQYYGLKEMNYYTVMFGVSRALGVLAQLI 439
G ++ GL + + V R+ G+LA ++
Sbjct: 204 GAIVAAMGLDPLIARGLAL-VGRSAGLLAHVL 234
>UniRef50_Q3HKI3 Cluster: Possible virC1; n=2; Rhodobacter
sphaeroides 2.4.1|Rep: Possible virC1 - Rhodobacter
sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 /
DSM158)
Length = 298
Score = 33.9 bits (74), Expect = 9.2
Identities = 21/76 (27%), Positives = 35/76 (46%)
Query: 20 TATVLLRGLSAEQTNLKSILQEKIPKEQEKIREFRKKHGSTKVGEVTVDMMYGGMRGIKG 79
T +++ + E ++L + P + K E K S + +D++Y K
Sbjct: 71 TTALMMLASAIEARGQSALLVDCDPHQSFKAYETHSKSTSPAIWSDRMDVIYLHYEATKV 130
Query: 80 LVWETSVLDADEGIRF 95
V E ++LDADEG RF
Sbjct: 131 AVLEQTLLDADEGGRF 146
>UniRef50_A4IPQ3 Cluster: Citrate synthase I; n=1; Geobacillus
thermodenitrificans NG80-2|Rep: Citrate synthase I -
Geobacillus thermodenitrificans (strain NG80-2)
Length = 280
Score = 33.9 bits (74), Expect = 9.2
Identities = 38/164 (23%), Positives = 68/164 (41%), Gaps = 8/164 (4%)
Query: 292 AAGLNGLAGPLHGLANQEVLVWLEKLRKQV----GDNFTEEQLKEFIWKTLKSGQVVPGY 347
A G+N L G +HG A ++ + + Q+ GD+ + E+ + + G+ +PG+
Sbjct: 101 ATGINVL-GDVHGGAVEKAMALFYETNGQIEARGGDDAISTVVSEWFEQFRREGRKLPGF 159
Query: 348 GHAVLRKTDPRYTCQREFALKHLPNDPLFKLVAAVYKVVPPILTELGKVKNPWPNVDSHS 407
GH L DPR A + + + + + L E K K N+D +
Sbjct: 160 GHQ-LHDDDPRVKRLYALAEQLMEEGEISGRYLTIAETYRSQL-EKAKGKKMTMNIDGVA 217
Query: 408 GVLLQYYGLKEMNYYTVMFGVSRALGVLAQLIWSRALGLPIERP 451
+ G+ V F +SR +G++A G+ I+ P
Sbjct: 218 AAIQCELGVPAAAAKGV-FALSRGMGIVAHAFEEWQNGVLIKGP 260
>UniRef50_A0UVE9 Cluster: Xylulokinase; n=1; Clostridium
cellulolyticum H10|Rep: Xylulokinase - Clostridium
cellulolyticum H10
Length = 503
Score = 33.9 bits (74), Expect = 9.2
Identities = 32/130 (24%), Positives = 55/130 (42%), Gaps = 14/130 (10%)
Query: 179 SESKFAKAYS--EGVHKSKYWEYVYEDTMNLIAKLPVIAATIYRNVYRD---GKGIGAID 233
S + F +YS + + K +Y T + +A + + +D G GI + +
Sbjct: 126 SGNSFEPSYSTPKFIWFKKNMPEIYNSTYKFLQSNSFVAFKLTGKMTQDLSQGYGIHSFN 185
Query: 234 DNKD-WSANYCNMLGFDDPQFTELMRLYLTIHSDHEGGNVSAHTTHLVGSALSDPYLSFA 292
N+ W ++C LGFD + E+ + + I G V+A G A+ P + A
Sbjct: 186 MNEGKWDDDFCEELGFDREKLPEIFQCHEVI------GEVTAEAAASTGLAIGTPVV--A 237
Query: 293 AGLNGLAGPL 302
GL+ G L
Sbjct: 238 GGLDASCGTL 247
>UniRef50_A2EPG1 Cluster: Viral A-type inclusion protein, putative;
n=1; Trichomonas vaginalis G3|Rep: Viral A-type
inclusion protein, putative - Trichomonas vaginalis G3
Length = 1297
Score = 33.9 bits (74), Expect = 9.2
Identities = 46/187 (24%), Positives = 81/187 (43%), Gaps = 9/187 (4%)
Query: 12 VELQKACPTATVLLRGLSAEQTNLKSILQE--KIPKEQEKIREFRKKHGSTKVGEVTVDM 69
+ELQK ++ LS E TN KS+ +E ++ E +I+E +++ + +
Sbjct: 70 IELQKEITQLKEQIQNLSTEATNNKSLNEEIQRLKSENTEIKEALERNKTQNKENSENEE 129
Query: 70 MYGGMRG-IKGLVWETSVLDAD-EGIRFRGLSIPECQQQLPKAKGGEEPLPEGLFWLLVT 127
+ + G + L E L + E ++ + + Q++L KA G + L L L
Sbjct: 130 VINQLTGENQKLTDENESLKSQIESLKKELSKLNQNQEELLKASGQTDELNNKLSNLEAE 189
Query: 128 GDIPTEAQAKALSKEWAARAELPAHVVTMLNNMPGKL-HPMSQFSAAVTALNSESKFAKA 186
TE + K+L E + + + T NNM ++ + A T N E +F +
Sbjct: 190 NKSLTE-KLKSLENENSTLLGFVSTLKTQFNNMNTEVQRVIGNLEAEKT--NLEEEF-EN 245
Query: 187 YSEGVHK 193
Y E HK
Sbjct: 246 YKENSHK 252
>UniRef50_A2DLI0 Cluster: Putative uncharacterized protein; n=1;
Trichomonas vaginalis G3|Rep: Putative uncharacterized
protein - Trichomonas vaginalis G3
Length = 314
Score = 33.9 bits (74), Expect = 9.2
Identities = 16/41 (39%), Positives = 23/41 (56%)
Query: 162 GKLHPMSQFSAAVTALNSESKFAKAYSEGVHKSKYWEYVYE 202
GK ++ FS V L S S F Y++ VH +KY ++YE
Sbjct: 33 GKSSLIANFSPEVKELQSRSTFGYEYTDFVHDNKYLIHIYE 73
Database: uniref50
Posted date: Oct 5, 2007 11:19 AM
Number of letters in database: 575,637,011
Number of sequences in database: 1,657,284
Lambda K H
0.318 0.135 0.402
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 532,105,413
Number of Sequences: 1657284
Number of extensions: 23126815
Number of successful extensions: 55152
Number of sequences better than 10.0: 126
Number of HSP's better than 10.0 without gapping: 78
Number of HSP's successfully gapped in prelim test: 48
Number of HSP's that attempted gapping in prelim test: 54844
Number of HSP's gapped (non-prelim): 145
length of query: 465
length of database: 575,637,011
effective HSP length: 103
effective length of query: 362
effective length of database: 404,936,759
effective search space: 146587106758
effective search space used: 146587106758
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.7 bits)
S2: 74 (33.9 bits)
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