Last updated: 2022/11/18
BLASTP 2.2.12 [Aug-07-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= BGIBMGA000642-TA|BGIBMGA000642-PA|IPR005963|Tyrosine
5-monooxygenase, IPR002912|Amino acid-binding ACT, IPR001273|Aromatic
amino acid hydroxylase
(502 letters)
Database: human
224,733 sequences; 73,234,838 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
L29306-1|AAA67050.1| 444|Homo sapiens tryptophan hydroxylase pr... 579 e-165
X52836-1|CAA37018.1| 444|Homo sapiens protein ( Human mRNA for ... 576 e-164
BC106739-1|AAI06740.1| 444|Homo sapiens tryptophan hydroxylase ... 576 e-164
AY098914-1|AAM28946.1| 490|Homo sapiens neuronal tryptophan hyd... 567 e-161
BC114499-1|AAI14500.1| 490|Homo sapiens tryptophan hydroxylase ... 566 e-161
BC114442-1|AAI14443.1| 496|Homo sapiens TPH2 protein protein. 566 e-161
U49897-1|AAC51772.1| 452|Homo sapiens phenylalanine hydroxylase... 461 e-129
K03020-1|AAA60082.1| 452|Homo sapiens phenylalanine hydroxylase... 461 e-129
AF404777-1|AAL78816.1| 452|Homo sapiens phenylalanine hydroxyla... 460 e-129
BC026251-1|AAH26251.1| 452|Homo sapiens phenylalanine hydroxyla... 458 e-128
BC104967-1|AAI04968.1| 497|Homo sapiens tyrosine hydroxylase pr... 401 e-111
Y00414-1|CAA68472.1| 524|Homo sapiens protein ( Human mRNA for ... 398 e-110
X05290-1|CAA28908.1| 497|Homo sapiens protein ( Human mRNA for ... 398 e-110
M17589-1|AAA61179.1| 528|Homo sapiens TH protein. 398 e-110
AY196344-1|AAO72075.1| 163|Homo sapiens tryptophan hydroxylase ... 245 2e-64
AY196345-1|AAO72074.1| 206|Homo sapiens tryptophan hydroxylase ... 221 3e-57
DQ677337-1|ABG73365.1| 407|Homo sapiens tyrosine hydroxylase is... 186 1e-46
DQ677336-1|ABG73364.1| 403|Homo sapiens tyrosine hydroxylase is... 186 1e-46
AK094614-1|BAC04385.1| 250|Homo sapiens protein ( Homo sapiens ... 147 9e-35
BC106740-1|AAI06741.1| 206|Homo sapiens TPH1 protein protein. 137 1e-31
AY144494-1|AAN39538.1| 115|Homo sapiens putative tyrosine hydro... 109 2e-23
AY196346-1|AAO72076.1| 74|Homo sapiens tryptophan hydroxylase ... 96 3e-19
AF057280-2|AAC69458.1| 57|Homo sapiens tryptophan hydroxylase ... 65 6e-10
AF057280-1|AAC69459.1| 79|Homo sapiens tryptophan hydroxylase ... 64 1e-09
AY144495-1|AAN39539.1| 44|Homo sapiens truncated tyrosine hydr... 61 1e-08
AY563525-1|AAS66667.1| 18|Homo sapiens phenylalanine hydroxyla... 38 0.062
S61396-1|AAD13928.1| 26|Homo sapiens PAH protein. 38 0.11
X81479-1|CAA57232.1| 886|Homo sapiens EMR1 protein. 36 0.25
S75697-1|AAD14181.1| 26|Homo sapiens PAH protein. 36 0.25
DQ217942-1|ABB70739.1| 886|Homo sapiens EGF-like module contain... 36 0.44
BC059395-1|AAH59395.1| 821|Homo sapiens EMR1 protein protein. 36 0.44
AK131562-1|BAD18695.1| 867|Homo sapiens protein ( Homo sapiens ... 36 0.44
AB065918-1|BAC06133.1| 929|Homo sapiens seven transmembrane hel... 36 0.44
AF044578-1|AAD02338.1| 579|Homo sapiens putative DNA polymerase... 33 1.8
S75699-1|AAD14182.1| 26|Homo sapiens PAH protein. 33 3.1
BC007216-1|AAH07216.1| 333|Homo sapiens C5orf4 protein protein. 33 3.1
BC004506-1|AAH04506.2| 299|Homo sapiens C5orf4 protein protein. 33 3.1
Z23024-1|CAA80560.1| 439|Homo sapiens rhoGAP protein protein. 32 4.1
U02570-1|AAA16142.1| 462|Homo sapiens CDC42 GTPase-activating p... 32 4.1
BC018118-1|AAH18118.1| 439|Homo sapiens Rho GTPase activating p... 32 4.1
AY722625-1|AAU11304.1| 17|Homo sapiens phenylalanine hydroxyla... 31 9.5
>L29306-1|AAA67050.1| 444|Homo sapiens tryptophan hydroxylase
protein.
Length = 444
Score = 579 bits (1429), Expect = e-165
Identities = 270/441 (61%), Positives = 341/441 (77%), Gaps = 12/441 (2%)
Query: 45 ESERISVMFTLKNQVGGLVRALSVFQDLGINVLHIESRKSMTEVSSADILVDVECDPQRM 104
E R +++F+LKN+VGGL++AL +FQ+ +N+LHIESRKS S +I VD + + +++
Sbjct: 14 ERGRATLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDTNREQL 73
Query: 105 EQLKRMLKREVQDFEVVPPQTGDEFPPPTPMSAAASFDFGEMPWFPRKISDLDRAQN-VL 163
+ +LK V PP D F +PWFP+KISDLD N VL
Sbjct: 74 NDIFHLLKSHTNVLSVTPP---DNF-------TMKEEGMESVPWFPKKISDLDHCANRVL 123
Query: 164 MYGSELDADHPGFKDPIYRKRREQFAAIANNYKYGHPIPKVQYTETEIKTWGIVFRELHK 223
MYGSELDADHPGFKD +YRKRR+ FA A +YKYG PIPKV++TE EIKTWG VFREL+K
Sbjct: 124 MYGSELDADHPGFKDNVYRKRRKYFADSAMSYKYGDPIPKVEFTEEEIKTWGTVFRELNK 183
Query: 224 LYQKHACPEYLENWPQLVKYCGYREDNLPQLEDVSSFLKRKTGFQLRPVAGYLSPRDFLS 283
LY HAC EYL+N P L KYCGY+EDN+PQLED+S+FLK +TGF +RPVAGYLSPRDFLS
Sbjct: 184 LYPTHACREYLKNLPLLSKYCGYQEDNIPQLEDISNFLKERTGFSIRPVAGYLSPRDFLS 243
Query: 284 GLAFRVFHCTQYIRHSSDPFYTPEPDCCHELLGHMPLLANPSFAQFSQELGLASLGASDA 343
GLAFRVFHCTQY+RHSSDPFYTPEPD CHELLGH+PLLA PSFAQFSQE+GLASLGAS+
Sbjct: 244 GLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEE 303
Query: 344 DIDKLATLYFFTVEFGLCRQPDGSFCVYGAGLLSSVAELQHALTTPEKIKRFDPDITVHE 403
+ KLAT YFFTVEFGLC+Q DG V+GAGLLSS++EL+H L+ K+K FDP IT +
Sbjct: 304 AVQKLATCYFFTVEFGLCKQ-DGQLRVFGAGLLSSISELKHVLSGHAKVKPFDPKITCKQ 362
Query: 404 ECIITSYQNAYYYTDSFEEAKEKMRAFAESIQRPFGVRYNPYTQSVEVLSNAQKITALVS 463
EC+IT++Q+ Y+ ++SFE+AKEKMR F ++I+RPFGV+YNPYT+S+++L +A+ IT ++
Sbjct: 363 ECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDAKSITNAMN 422
Query: 464 ELRGDLCIVSSAIKKISAQDS 484
ELR DL +VS A+ K+S + S
Sbjct: 423 ELRHDLDVVSDALGKVSRKPS 443
>X52836-1|CAA37018.1| 444|Homo sapiens protein ( Human mRNA for
tryptophan hydroxylase (EC 1.14.16.4). ).
Length = 444
Score = 576 bits (1423), Expect = e-164
Identities = 270/441 (61%), Positives = 342/441 (77%), Gaps = 12/441 (2%)
Query: 45 ESERISVMFTLKNQVGGLVRALSVFQDLGINVLHIESRKSMTEVSSADILVDVECDPQRM 104
E R S++F+LKN+VGGL++AL +FQ+ +N+LHIESRKS S +I VD + + +++
Sbjct: 14 ERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQL 73
Query: 105 EQLKRMLKREVQDFEVVPPQTGDEFPPPTPMSAAASFDFGEMPWFPRKISDLDRAQN-VL 163
+ +LK V P D F +PWFP+KISDLD N VL
Sbjct: 74 NDIFHLLKSHTNVLSVNLP---DNF-------TLKEDGMETVPWFPKKISDLDHCANRVL 123
Query: 164 MYGSELDADHPGFKDPIYRKRREQFAAIANNYKYGHPIPKVQYTETEIKTWGIVFRELHK 223
MYGSELDADHPGFKD +YRKRR+ FA +A NYK+G PIPKV++TE EIKTWG VF+EL+K
Sbjct: 124 MYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNK 183
Query: 224 LYQKHACPEYLENWPQLVKYCGYREDNLPQLEDVSSFLKRKTGFQLRPVAGYLSPRDFLS 283
LY HAC EYL+N P L KYCGYREDN+PQLEDVS+FLK +TGF +RPVAGYLSPRDFLS
Sbjct: 184 LYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLS 243
Query: 284 GLAFRVFHCTQYIRHSSDPFYTPEPDCCHELLGHMPLLANPSFAQFSQELGLASLGASDA 343
GLAFRVFHCTQY+RHSSDPFYTPEPD CHELLGH+PLLA PSFAQFSQE+GLASLGAS+
Sbjct: 244 GLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEE 303
Query: 344 DIDKLATLYFFTVEFGLCRQPDGSFCVYGAGLLSSVAELQHALTTPEKIKRFDPDITVHE 403
+ KLAT YFFTVEFGLC+Q DG V+GAGLLSS++EL+HAL+ K+K FDP IT +
Sbjct: 304 AVQKLATCYFFTVEFGLCKQ-DGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITCKQ 362
Query: 404 ECIITSYQNAYYYTDSFEEAKEKMRAFAESIQRPFGVRYNPYTQSVEVLSNAQKITALVS 463
EC+IT++Q+ Y+ ++SFE+AKEKMR F ++I+RPFGV+YNPYT+S+++L + + IT+ ++
Sbjct: 363 ECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSAMN 422
Query: 464 ELRGDLCIVSSAIKKISAQDS 484
EL+ DL +VS A+ K+S + S
Sbjct: 423 ELQHDLDVVSDALAKVSRKPS 443
>BC106739-1|AAI06740.1| 444|Homo sapiens tryptophan hydroxylase 1
(tryptophan 5-monooxygenase) protein.
Length = 444
Score = 576 bits (1423), Expect = e-164
Identities = 270/441 (61%), Positives = 342/441 (77%), Gaps = 12/441 (2%)
Query: 45 ESERISVMFTLKNQVGGLVRALSVFQDLGINVLHIESRKSMTEVSSADILVDVECDPQRM 104
E R S++F+LKN+VGGL++AL +FQ+ +N+LHIESRKS S +I VD + + +++
Sbjct: 14 ERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQL 73
Query: 105 EQLKRMLKREVQDFEVVPPQTGDEFPPPTPMSAAASFDFGEMPWFPRKISDLDRAQN-VL 163
+ +LK V P D F +PWFP+KISDLD N VL
Sbjct: 74 NDIFHLLKSHTNVLSVNLP---DNF-------TLKEDGMETVPWFPKKISDLDHCANRVL 123
Query: 164 MYGSELDADHPGFKDPIYRKRREQFAAIANNYKYGHPIPKVQYTETEIKTWGIVFRELHK 223
MYGSELDADHPGFKD +YRKRR+ FA +A NYK+G PIPKV++TE EIKTWG VF+EL+K
Sbjct: 124 MYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNK 183
Query: 224 LYQKHACPEYLENWPQLVKYCGYREDNLPQLEDVSSFLKRKTGFQLRPVAGYLSPRDFLS 283
LY HAC EYL+N P L KYCGYREDN+PQLEDVS+FLK +TGF +RPVAGYLSPRDFLS
Sbjct: 184 LYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLS 243
Query: 284 GLAFRVFHCTQYIRHSSDPFYTPEPDCCHELLGHMPLLANPSFAQFSQELGLASLGASDA 343
GLAFRVFHCTQY+RHSSDPFYTPEPD CHELLGH+PLLA PSFAQFSQE+GLASLGAS+
Sbjct: 244 GLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEE 303
Query: 344 DIDKLATLYFFTVEFGLCRQPDGSFCVYGAGLLSSVAELQHALTTPEKIKRFDPDITVHE 403
+ KLAT YFFTVEFGLC+Q DG V+GAGLLSS++EL+HAL+ K+K FDP IT +
Sbjct: 304 AVQKLATCYFFTVEFGLCKQ-DGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITCKQ 362
Query: 404 ECIITSYQNAYYYTDSFEEAKEKMRAFAESIQRPFGVRYNPYTQSVEVLSNAQKITALVS 463
EC+IT++Q+ Y+ ++SFE+AKEKMR F ++I+RPFGV+YNPYT+S+++L + + IT+ ++
Sbjct: 363 ECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSAMN 422
Query: 464 ELRGDLCIVSSAIKKISAQDS 484
EL+ DL +VS A+ K+S + S
Sbjct: 423 ELQHDLDVVSDALAKVSRKPS 443
>AY098914-1|AAM28946.1| 490|Homo sapiens neuronal tryptophan
hydroxylase protein.
Length = 490
Score = 567 bits (1400), Expect = e-161
Identities = 268/465 (57%), Positives = 341/465 (73%), Gaps = 12/465 (2%)
Query: 17 GSDWQVKNESPHHPKLGELHAARVQAQAESERISVMFTLKNQVGGLVRALSVFQDLGINV 76
GS K S + G +++ +A ES + +V+F+LKN+VGGLV+AL +FQ+ +N+
Sbjct: 32 GSSTLNKPNSGKNDDKGNKGSSKREAATESGKTAVVFSLKNEVGGLVKALRLFQEKRVNM 91
Query: 77 LHIESRKSMTEVSSADILVDVECDPQRMEQLKRMLKREVQDFEVVPPQTGDEFPPPTPMS 136
+HIESRKS S +I VD EC +L ++LK + + PP+
Sbjct: 92 VHIESRKSRRRSSEVEIFVDCECGKTEFNELIQLLKFQTTIVTLNPPEN----------I 141
Query: 137 AAASFDFGEMPWFPRKISDLDRAQN-VLMYGSELDADHPGFKDPIYRKRREQFAAIANNY 195
+ ++PWFPRKIS+LD+ + VLMYGSELDADHPGFKD +YR+RR+ F +A Y
Sbjct: 142 WTEEEELEDVPWFPRKISELDKCSHRVLMYGSELDADHPGFKDNVYRQRRKYFVDVAMGY 201
Query: 196 KYGHPIPKVQYTETEIKTWGIVFRELHKLYQKHACPEYLENWPQLVKYCGYREDNLPQLE 255
KYG PIP+V+YTE E KTWG+VFREL KLY HAC EYL+N+P L KYCGYREDN+PQLE
Sbjct: 202 KYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYLKNFPLLTKYCGYREDNVPQLE 261
Query: 256 DVSSFLKRKTGFQLRPVAGYLSPRDFLSGLAFRVFHCTQYIRHSSDPFYTPEPDCCHELL 315
DVS FLK ++GF +RPVAGYLSPRDFL+GLA+RVFHCTQYIRH SDP YTPEPD CHELL
Sbjct: 262 DVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQYIRHGSDPLYTPEPDTCHELL 321
Query: 316 GHMPLLANPSFAQFSQELGLASLGASDADIDKLATLYFFTVEFGLCRQPDGSFCVYGAGL 375
GH+PLLA+P FAQFSQE+GLASLGASD D+ KLAT YFFT+EFGLC+Q +G YGAGL
Sbjct: 322 GHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFFTIEFGLCKQ-EGQLRAYGAGL 380
Query: 376 LSSVAELQHALTTPEKIKRFDPDITVHEECIITSYQNAYYYTDSFEEAKEKMRAFAESIQ 435
LSS+ EL+HAL+ +K FDP T +EC+IT++Q AY+ ++SFEEAKEKMR FA+SI
Sbjct: 381 LSSIGELKHALSDKACVKAFDPKTTCLQECLITTFQEAYFVSESFEEAKEKMRDFAKSIT 440
Query: 436 RPFGVRYNPYTQSVEVLSNAQKITALVSELRGDLCIVSSAIKKIS 480
RPF V +NPYTQS+E+L + + I +V +LR DL V A+ K++
Sbjct: 441 RPFSVYFNPYTQSIEILKDTRSIENVVQDLRSDLNTVCDALNKMN 485
>BC114499-1|AAI14500.1| 490|Homo sapiens tryptophan hydroxylase 2
protein.
Length = 490
Score = 566 bits (1397), Expect = e-161
Identities = 268/465 (57%), Positives = 340/465 (73%), Gaps = 12/465 (2%)
Query: 17 GSDWQVKNESPHHPKLGELHAARVQAQAESERISVMFTLKNQVGGLVRALSVFQDLGINV 76
GS K S + G + + +A ES + +V+F+LKN+VGGLV+AL +FQ+ +N+
Sbjct: 32 GSSTLNKPNSGKNDDKGNKGSNKREAATESGKTAVVFSLKNEVGGLVKALRLFQEKRVNM 91
Query: 77 LHIESRKSMTEVSSADILVDVECDPQRMEQLKRMLKREVQDFEVVPPQTGDEFPPPTPMS 136
+HIESRKS S +I VD EC +L ++LK + + PP+
Sbjct: 92 VHIESRKSRRRSSEVEIFVDCECGKTEFNELIQLLKFQTTIVTLNPPEN----------I 141
Query: 137 AAASFDFGEMPWFPRKISDLDRAQN-VLMYGSELDADHPGFKDPIYRKRREQFAAIANNY 195
+ ++PWFPRKIS+LD+ + VLMYGSELDADHPGFKD +YR+RR+ F +A Y
Sbjct: 142 WTEEEELEDVPWFPRKISELDKCSHRVLMYGSELDADHPGFKDNVYRQRRKYFVDVAMGY 201
Query: 196 KYGHPIPKVQYTETEIKTWGIVFRELHKLYQKHACPEYLENWPQLVKYCGYREDNLPQLE 255
KYG PIP+V+YTE E KTWG+VFREL KLY HAC EYL+N+P L KYCGYREDN+PQLE
Sbjct: 202 KYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYLKNFPLLTKYCGYREDNVPQLE 261
Query: 256 DVSSFLKRKTGFQLRPVAGYLSPRDFLSGLAFRVFHCTQYIRHSSDPFYTPEPDCCHELL 315
DVS FLK ++GF +RPVAGYLSPRDFL+GLA+RVFHCTQYIRH SDP YTPEPD CHELL
Sbjct: 262 DVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQYIRHGSDPLYTPEPDTCHELL 321
Query: 316 GHMPLLANPSFAQFSQELGLASLGASDADIDKLATLYFFTVEFGLCRQPDGSFCVYGAGL 375
GH+PLLA+P FAQFSQE+GLASLGASD D+ KLAT YFFT+EFGLC+Q +G YGAGL
Sbjct: 322 GHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFFTIEFGLCKQ-EGQLRAYGAGL 380
Query: 376 LSSVAELQHALTTPEKIKRFDPDITVHEECIITSYQNAYYYTDSFEEAKEKMRAFAESIQ 435
LSS+ EL+HAL+ +K FDP T +EC+IT++Q AY+ ++SFEEAKEKMR FA+SI
Sbjct: 381 LSSIGELKHALSDKACVKAFDPKTTCLQECLITTFQEAYFVSESFEEAKEKMRDFAKSIT 440
Query: 436 RPFGVRYNPYTQSVEVLSNAQKITALVSELRGDLCIVSSAIKKIS 480
RPF V +NPYTQS+E+L + + I +V +LR DL V A+ K++
Sbjct: 441 RPFSVYFNPYTQSIEILKDTRSIENVVQDLRSDLNTVCDALNKMN 485
>BC114442-1|AAI14443.1| 496|Homo sapiens TPH2 protein protein.
Length = 496
Score = 566 bits (1397), Expect = e-161
Identities = 266/459 (57%), Positives = 339/459 (73%), Gaps = 12/459 (2%)
Query: 23 KNESPHHPKLGELHAARVQAQAESERISVMFTLKNQVGGLVRALSVFQDLGINVLHIESR 82
K S + G +++ +A ES + +V+F+LKN+VGGLV+AL +FQ+ +N++HIESR
Sbjct: 44 KPNSGKNDDKGNKGSSKREAATESGKTAVVFSLKNEVGGLVKALRLFQEKRVNMVHIESR 103
Query: 83 KSMTEVSSADILVDVECDPQRMEQLKRMLKREVQDFEVVPPQTGDEFPPPTPMSAAASFD 142
KS S +I VD EC +L ++LK + + PP+ +
Sbjct: 104 KSRRRSSEVEIFVDCECGKTEFNELIQLLKFQTTIVTLNPPEN----------IWTEEEE 153
Query: 143 FGEMPWFPRKISDLDRAQN-VLMYGSELDADHPGFKDPIYRKRREQFAAIANNYKYGHPI 201
++PWFPRKIS+LD+ + VLMYGSELDADHPGFKD +YR+RR+ F +A YKYG PI
Sbjct: 154 LEDVPWFPRKISELDKCSHRVLMYGSELDADHPGFKDNVYRQRRKYFVDVAMGYKYGQPI 213
Query: 202 PKVQYTETEIKTWGIVFRELHKLYQKHACPEYLENWPQLVKYCGYREDNLPQLEDVSSFL 261
P+V+YTE E KTWG+VFREL KLY HAC EYL+N+P L KYCGYREDN+PQLEDVS FL
Sbjct: 214 PRVEYTEEETKTWGVVFRELSKLYPTHACREYLKNFPLLTKYCGYREDNVPQLEDVSMFL 273
Query: 262 KRKTGFQLRPVAGYLSPRDFLSGLAFRVFHCTQYIRHSSDPFYTPEPDCCHELLGHMPLL 321
K ++GF +RPVAGYLSPRDFL+GLA+RVFHCTQYIRH SDP YTPEPD CHELLGH+PLL
Sbjct: 274 KERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQYIRHGSDPLYTPEPDTCHELLGHVPLL 333
Query: 322 ANPSFAQFSQELGLASLGASDADIDKLATLYFFTVEFGLCRQPDGSFCVYGAGLLSSVAE 381
A+P FAQFSQE+GLASLGASD D+ KLAT YFFT+EFGLC+Q +G YGAGLLSS+ E
Sbjct: 334 ADPKFAQFSQEIGLASLGASDEDVQKLATCYFFTIEFGLCKQ-EGQLRAYGAGLLSSIGE 392
Query: 382 LQHALTTPEKIKRFDPDITVHEECIITSYQNAYYYTDSFEEAKEKMRAFAESIQRPFGVR 441
L+HAL+ +K FDP T +EC+IT++Q AY+ ++SFEEAKEKMR FA+SI RPF V
Sbjct: 393 LKHALSDKACVKAFDPKTTCLQECLITTFQEAYFVSESFEEAKEKMRDFAKSITRPFSVY 452
Query: 442 YNPYTQSVEVLSNAQKITALVSELRGDLCIVSSAIKKIS 480
+NPYTQS+E+L + + I +V +LR DL V A+ K++
Sbjct: 453 FNPYTQSIEILKDTRSIENVVQDLRSDLNTVCDALNKMN 491
>U49897-1|AAC51772.1| 452|Homo sapiens phenylalanine hydroxylase
protein.
Length = 452
Score = 461 bits (1137), Expect = e-129
Identities = 227/432 (52%), Positives = 293/432 (67%), Gaps = 16/432 (3%)
Query: 49 ISVMFTLKNQVGGLVRALSVFQDLGINVLHIESRKSMTEVSSADILVDVECDPQRMEQLK 108
IS++F+LK +VG L + L +F++ +N+ HIESR S + + + D + + L
Sbjct: 35 ISLIFSLKEEVGALAKVLRLFEENDVNLTHIESRPSRLKKDEYEFFTHL--DKRSLPALT 92
Query: 109 RMLKREVQDFEVVPPQTGDEFPPPTPMSAAASFDFGEMPWFPRKISDLDR-AQNVLMYGS 167
++K D + + T +PWFPR I +LDR A +L YG+
Sbjct: 93 NIIKILRHDIGATVHELSRDKKKDT------------VPWFPRTIQELDRFANQILSYGA 140
Query: 168 ELDADHPGFKDPIYRKRREQFAAIANNYKYGHPIPKVQYTETEIKTWGIVFRELHKLYQK 227
ELDADHPGFKDP+YR RR+QFA IA NY++G PIP+V+Y E E KTWG VF+ L LY+
Sbjct: 141 ELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYMEEEKKTWGTVFKTLKSLYKT 200
Query: 228 HACPEYLENWPQLVKYCGYREDNLPQLEDVSSFLKRKTGFQLRPVAGYLSPRDFLSGLAF 287
HAC EY +P L KYCG+ EDN+PQLEDVS FL+ TGF+LRPVAG LS RDFL GLAF
Sbjct: 201 HACYEYNHIFPLLEKYCGFHEDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRDFLGGLAF 260
Query: 288 RVFHCTQYIRHSSDPFYTPEPDCCHELLGHMPLLANPSFAQFSQELGLASLGASDADIDK 347
RVFHCTQYIRH S P YTPEPD CHELLGH+PL ++ SFAQFSQE+GLASLGA D I+K
Sbjct: 261 RVFHCTQYIRHGSKPMYTPEPDICHELLGHVPLFSDRSFAQFSQEIGLASLGAPDEYIEK 320
Query: 348 LATLYFFTVEFGLCRQPDGSFCVYGAGLLSSVAELQHALTTPEKIKRFDPDITVHEECII 407
LAT+Y+FTVEFGLC+Q D S YGAGLLSS ELQ+ L+ K+ + + T + +
Sbjct: 321 LATIYWFTVEFGLCKQGD-SIKAYGAGLLSSFGELQYCLSEKPKLLPLELEKTAIQNYTV 379
Query: 408 TSYQNAYYYTDSFEEAKEKMRAFAESIQRPFGVRYNPYTQSVEVLSNAQKITALVSELRG 467
T +Q YY +SF +AKEK+R FA +I RPF VRY+PYTQ +EVL N Q++ L +
Sbjct: 380 TEFQPLYYVAESFNDAKEKVRNFAATIPRPFSVRYDPYTQRIEVLDNTQQLKILADSINS 439
Query: 468 DLCIVSSAIKKI 479
++ I+ SA++KI
Sbjct: 440 EIGILCSALQKI 451
>K03020-1|AAA60082.1| 452|Homo sapiens phenylalanine hydroxylase
protein.
Length = 452
Score = 461 bits (1137), Expect = e-129
Identities = 227/432 (52%), Positives = 293/432 (67%), Gaps = 16/432 (3%)
Query: 49 ISVMFTLKNQVGGLVRALSVFQDLGINVLHIESRKSMTEVSSADILVDVECDPQRMEQLK 108
IS++F+LK +VG L + L +F++ +N+ HIESR S + + + D + + L
Sbjct: 35 ISLIFSLKEEVGALAKVLRLFEENDVNLTHIESRPSRLKKDEYEFFTHL--DKRSLPALT 92
Query: 109 RMLKREVQDFEVVPPQTGDEFPPPTPMSAAASFDFGEMPWFPRKISDLDR-AQNVLMYGS 167
++K D + + T +PWFPR I +LDR A +L YG+
Sbjct: 93 NIIKILRHDIGATVHELSRDKKKDT------------VPWFPRTIQELDRFANQILSYGA 140
Query: 168 ELDADHPGFKDPIYRKRREQFAAIANNYKYGHPIPKVQYTETEIKTWGIVFRELHKLYQK 227
ELDADHPGFKDP+YR RR+QFA IA NY++G PIP+V+Y E E KTWG VF+ L LY+
Sbjct: 141 ELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYMEEEKKTWGTVFKTLKSLYKT 200
Query: 228 HACPEYLENWPQLVKYCGYREDNLPQLEDVSSFLKRKTGFQLRPVAGYLSPRDFLSGLAF 287
HAC EY +P L KYCG+ EDN+PQLEDVS FL+ TGF+LRPVAG LS RDFL GLAF
Sbjct: 201 HACYEYNHIFPLLEKYCGFHEDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRDFLGGLAF 260
Query: 288 RVFHCTQYIRHSSDPFYTPEPDCCHELLGHMPLLANPSFAQFSQELGLASLGASDADIDK 347
RVFHCTQYIRH S P YTPEPD CHELLGH+PL ++ SFAQFSQE+GLASLGA D I+K
Sbjct: 261 RVFHCTQYIRHGSKPMYTPEPDICHELLGHVPLFSDRSFAQFSQEIGLASLGAPDEYIEK 320
Query: 348 LATLYFFTVEFGLCRQPDGSFCVYGAGLLSSVAELQHALTTPEKIKRFDPDITVHEECII 407
LAT+Y+FTVEFGLC+Q D S YGAGLLSS ELQ+ L+ K+ + + T + +
Sbjct: 321 LATIYWFTVEFGLCKQGD-SIKAYGAGLLSSFGELQYCLSEKPKLLPLELEKTAIQNYTV 379
Query: 408 TSYQNAYYYTDSFEEAKEKMRAFAESIQRPFGVRYNPYTQSVEVLSNAQKITALVSELRG 467
T +Q YY +SF +AKEK+R FA +I RPF VRY+PYTQ +EVL N Q++ L +
Sbjct: 380 TEFQPLYYVAESFNDAKEKVRNFAATIPRPFSVRYDPYTQRIEVLDNTQQLKILADSINS 439
Query: 468 DLCIVSSAIKKI 479
++ I+ SA++KI
Sbjct: 440 EIGILCSALQKI 451
>AF404777-1|AAL78816.1| 452|Homo sapiens phenylalanine hydroxylase
protein.
Length = 452
Score = 460 bits (1134), Expect = e-129
Identities = 226/432 (52%), Positives = 293/432 (67%), Gaps = 16/432 (3%)
Query: 49 ISVMFTLKNQVGGLVRALSVFQDLGINVLHIESRKSMTEVSSADILVDVECDPQRMEQLK 108
IS++F+LK +VG L + L +F++ +N+ HIESR S + + + D + + L
Sbjct: 35 ISLIFSLKEEVGALAKVLRLFEENDVNLTHIESRPSRLKKDEYEFFTHL--DKRSLPALT 92
Query: 109 RMLKREVQDFEVVPPQTGDEFPPPTPMSAAASFDFGEMPWFPRKISDLDR-AQNVLMYGS 167
++K D + + T +PWFPR I +LDR A +L YG+
Sbjct: 93 NIIKILRHDIGATVHELSRDKKKDT------------VPWFPRTIQELDRFANQILSYGA 140
Query: 168 ELDADHPGFKDPIYRKRREQFAAIANNYKYGHPIPKVQYTETEIKTWGIVFRELHKLYQK 227
ELDADHPGFKDP+YR RR+QFA IA NY++G PIP+V+Y E E KTWG VF+ L LY+
Sbjct: 141 ELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYMEEEKKTWGTVFKTLKSLYKT 200
Query: 228 HACPEYLENWPQLVKYCGYREDNLPQLEDVSSFLKRKTGFQLRPVAGYLSPRDFLSGLAF 287
HAC EY +P L KYCG+ EDN+PQLEDVS FL+ TGF+LRPVAG LS RDFL GLAF
Sbjct: 201 HACYEYNHIFPLLEKYCGFHEDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRDFLGGLAF 260
Query: 288 RVFHCTQYIRHSSDPFYTPEPDCCHELLGHMPLLANPSFAQFSQELGLASLGASDADIDK 347
RVFHCTQYIRH S P YTP+PD CHELLGH+PL ++ SFAQFSQE+GLASLGA D I+K
Sbjct: 261 RVFHCTQYIRHGSKPMYTPQPDICHELLGHVPLFSDRSFAQFSQEIGLASLGAPDEYIEK 320
Query: 348 LATLYFFTVEFGLCRQPDGSFCVYGAGLLSSVAELQHALTTPEKIKRFDPDITVHEECII 407
LAT+Y+FTVEFGLC+Q D S YGAGLLSS ELQ+ L+ K+ + + T + +
Sbjct: 321 LATIYWFTVEFGLCKQGD-SIKAYGAGLLSSFGELQYCLSEKPKLLPLELEKTAIQNYTV 379
Query: 408 TSYQNAYYYTDSFEEAKEKMRAFAESIQRPFGVRYNPYTQSVEVLSNAQKITALVSELRG 467
T +Q YY +SF +AKEK+R FA +I RPF VRY+PYTQ +EVL N Q++ L +
Sbjct: 380 TEFQPLYYVAESFNDAKEKVRNFAATIPRPFSVRYDPYTQRIEVLDNTQQLKILADSINS 439
Query: 468 DLCIVSSAIKKI 479
++ I+ SA++KI
Sbjct: 440 EIGILCSALQKI 451
>BC026251-1|AAH26251.1| 452|Homo sapiens phenylalanine hydroxylase
protein.
Length = 452
Score = 458 bits (1130), Expect = e-128
Identities = 226/432 (52%), Positives = 292/432 (67%), Gaps = 16/432 (3%)
Query: 49 ISVMFTLKNQVGGLVRALSVFQDLGINVLHIESRKSMTEVSSADILVDVECDPQRMEQLK 108
IS++F+LK +VG L + L +F++ +N+ HIESR S + + + D + + L
Sbjct: 35 ISLIFSLKEEVGALAKVLRLFEENDVNLTHIESRPSRLKKDEYEFFTHL--DKRSLPALT 92
Query: 109 RMLKREVQDFEVVPPQTGDEFPPPTPMSAAASFDFGEMPWFPRKISDLDR-AQNVLMYGS 167
++K D + + T +PWFPR I +LDR A +L YG+
Sbjct: 93 NIIKILRHDIGATVHELSRDKKKDT------------VPWFPRTIQELDRFANQILSYGA 140
Query: 168 ELDADHPGFKDPIYRKRREQFAAIANNYKYGHPIPKVQYTETEIKTWGIVFRELHKLYQK 227
ELDADHPGFKDP+YR RR+QFA IA NY++G PIP+V+Y E KTWG VF+ L LY+
Sbjct: 141 ELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYMEEGKKTWGTVFKTLKSLYKT 200
Query: 228 HACPEYLENWPQLVKYCGYREDNLPQLEDVSSFLKRKTGFQLRPVAGYLSPRDFLSGLAF 287
HAC EY +P L KYCG+ EDN+PQLEDVS FL+ TGF+LRPVAG LS RDFL GLAF
Sbjct: 201 HACYEYNHIFPLLEKYCGFHEDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRDFLGGLAF 260
Query: 288 RVFHCTQYIRHSSDPFYTPEPDCCHELLGHMPLLANPSFAQFSQELGLASLGASDADIDK 347
RVFHCTQYIRH S P YTPEPD CHELLGH+PL ++ SFAQFSQE+GLASLGA D I+K
Sbjct: 261 RVFHCTQYIRHGSKPMYTPEPDICHELLGHVPLFSDRSFAQFSQEIGLASLGAPDEYIEK 320
Query: 348 LATLYFFTVEFGLCRQPDGSFCVYGAGLLSSVAELQHALTTPEKIKRFDPDITVHEECII 407
LAT+Y+FTVEFGLC+Q D S YGAGLLSS ELQ+ L+ K+ + + T + +
Sbjct: 321 LATIYWFTVEFGLCKQGD-SIKAYGAGLLSSFGELQYCLSEKPKLLPLELEKTAIQNYTV 379
Query: 408 TSYQNAYYYTDSFEEAKEKMRAFAESIQRPFGVRYNPYTQSVEVLSNAQKITALVSELRG 467
T +Q YY +SF +AKEK+R FA +I RPF VRY+PYTQ +EVL N Q++ L +
Sbjct: 380 TEFQPLYYVAESFNDAKEKVRNFAATIPRPFSVRYDPYTQRIEVLDNTQQLKILADSINS 439
Query: 468 DLCIVSSAIKKI 479
++ I+ SA++KI
Sbjct: 440 EIGILCSALQKI 451
>BC104967-1|AAI04968.1| 497|Homo sapiens tyrosine hydroxylase
protein.
Length = 497
Score = 401 bits (988), Expect = e-111
Identities = 182/336 (54%), Positives = 250/336 (74%), Gaps = 2/336 (0%)
Query: 145 EMPWFPRKISDLDRAQN-VLMYGSELDADHPGFKDPIYRKRREQFAAIANNYKYGHPIPK 203
++PWFPRK+S+LD+ + V + +LD DHPGF D +YR+RR+ A IA Y++G PIP+
Sbjct: 162 KVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYRHGDPIPR 221
Query: 204 VQYTETEIKTWGIVFRELHKLYQKHACPEYLENWPQLVKYCGYREDNLPQLEDVSSFLKR 263
V+YT EI TW V+ L LY HAC E+LE + L ++ GYREDN+PQLEDVS FLK
Sbjct: 222 VEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNIPQLEDVSRFLKE 281
Query: 264 KTGFQLRPVAGYLSPRDFLSGLAFRVFHCTQYIRHSSDPFYTPEPDCCHELLGHMPLLAN 323
+TGFQLRPVAG LS RDFL+ LAFRVF CTQYIRH+S P ++PEPDCCHELLGH+P+LA+
Sbjct: 282 RTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLAD 341
Query: 324 PSFAQFSQELGLASLGASDADIDKLATLYFFTVEFGLCRQPDGSFCVYGAGLLSSVAELQ 383
+FAQFSQ++GLASLGASD +I+KL+TLY+FTVEFGLC+Q +G YGAGLLSS EL
Sbjct: 342 RTFAQFSQDIGLASLGASDEEIEKLSTLYWFTVEFGLCKQ-NGEVKAYGAGLLSSYGELL 400
Query: 384 HALTTPEKIKRFDPDITVHEECIITSYQNAYYYTDSFEEAKEKMRAFAESIQRPFGVRYN 443
H L+ +I+ FDP+ + +YQ+ Y+ ++SF +AK+K+R++A IQRPF V+++
Sbjct: 401 HCLSEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYASRIQRPFSVKFD 460
Query: 444 PYTQSVEVLSNAQKITALVSELRGDLCIVSSAIKKI 479
PYT +++VL + Q + + ++ +L ++ A+ I
Sbjct: 461 PYTLAIDVLDSPQAVRRSLEGVQDELDTLAHALSAI 496
>Y00414-1|CAA68472.1| 524|Homo sapiens protein ( Human mRNA for
tyrosine hydroxylase type 3. ).
Length = 524
Score = 398 bits (979), Expect = e-110
Identities = 181/336 (53%), Positives = 249/336 (74%), Gaps = 2/336 (0%)
Query: 145 EMPWFPRKISDLDRAQN-VLMYGSELDADHPGFKDPIYRKRREQFAAIANNYKYGHPIPK 203
++PWFPRK+S+LD+ + V + +LD DHPGF D +YR+RR+ A IA Y++G PIP+
Sbjct: 189 KVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYRHGDPIPR 248
Query: 204 VQYTETEIKTWGIVFRELHKLYQKHACPEYLENWPQLVKYCGYREDNLPQLEDVSSFLKR 263
V+YT EI TW V+ L LY HAC E+LE + L ++ GYREDN+PQLEDVS FLK
Sbjct: 249 VEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNIPQLEDVSRFLKE 308
Query: 264 KTGFQLRPVAGYLSPRDFLSGLAFRVFHCTQYIRHSSDPFYTPEPDCCHELLGHMPLLAN 323
+TGFQLRPVAG LS RDFL+ LAFRVF CTQYIRH+S P ++PEPDCCHELLGH+P+LA+
Sbjct: 309 RTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLAD 368
Query: 324 PSFAQFSQELGLASLGASDADIDKLATLYFFTVEFGLCRQPDGSFCVYGAGLLSSVAELQ 383
+FAQFSQ++GLASLGASD +I+KL+TL +FTVEFGLC+Q +G YGAGLLSS EL
Sbjct: 369 RTFAQFSQDIGLASLGASDEEIEKLSTLSWFTVEFGLCKQ-NGEVKAYGAGLLSSYGELL 427
Query: 384 HALTTPEKIKRFDPDITVHEECIITSYQNAYYYTDSFEEAKEKMRAFAESIQRPFGVRYN 443
H L+ +I+ FDP+ + +YQ+ Y+ ++SF +AK+K+R++A IQRPF V+++
Sbjct: 428 HCLSEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYASRIQRPFSVKFD 487
Query: 444 PYTQSVEVLSNAQKITALVSELRGDLCIVSSAIKKI 479
PYT +++VL + Q + + ++ +L ++ A+ I
Sbjct: 488 PYTLAIDVLDSPQAVRRSLEGVQDELDTLAHALSAI 523
>X05290-1|CAA28908.1| 497|Homo sapiens protein ( Human mRNA for
tyrosine hydroxylase (HTH-1). ).
Length = 497
Score = 398 bits (979), Expect = e-110
Identities = 181/336 (53%), Positives = 249/336 (74%), Gaps = 2/336 (0%)
Query: 145 EMPWFPRKISDLDRAQN-VLMYGSELDADHPGFKDPIYRKRREQFAAIANNYKYGHPIPK 203
++PWFPRK+S+LD+ + V + +LD DHPGF D +YR+RR+ A IA Y++G PIP+
Sbjct: 162 KVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYRHGDPIPR 221
Query: 204 VQYTETEIKTWGIVFRELHKLYQKHACPEYLENWPQLVKYCGYREDNLPQLEDVSSFLKR 263
V+YT EI TW V+ L LY HAC E+LE + L ++ GYREDN+PQLEDVS FLK
Sbjct: 222 VEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNIPQLEDVSRFLKE 281
Query: 264 KTGFQLRPVAGYLSPRDFLSGLAFRVFHCTQYIRHSSDPFYTPEPDCCHELLGHMPLLAN 323
+TGFQLRPVAG LS RDFL+ LAFRVF CTQYIRH+S P ++PEPDCCHELLGH+P+LA+
Sbjct: 282 RTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLAD 341
Query: 324 PSFAQFSQELGLASLGASDADIDKLATLYFFTVEFGLCRQPDGSFCVYGAGLLSSVAELQ 383
+FAQFSQ++GLASLGASD +I+KL+TL +FTVEFGLC+Q +G YGAGLLSS EL
Sbjct: 342 RTFAQFSQDIGLASLGASDEEIEKLSTLSWFTVEFGLCKQ-NGEVKAYGAGLLSSYGELL 400
Query: 384 HALTTPEKIKRFDPDITVHEECIITSYQNAYYYTDSFEEAKEKMRAFAESIQRPFGVRYN 443
H L+ +I+ FDP+ + +YQ+ Y+ ++SF +AK+K+R++A IQRPF V+++
Sbjct: 401 HCLSEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYASRIQRPFSVKFD 460
Query: 444 PYTQSVEVLSNAQKITALVSELRGDLCIVSSAIKKI 479
PYT +++VL + Q + + ++ +L ++ A+ I
Sbjct: 461 PYTLAIDVLDSPQAVRRSLEGVQDELDTLAHALSAI 496
>M17589-1|AAA61179.1| 528|Homo sapiens TH protein.
Length = 528
Score = 398 bits (979), Expect = e-110
Identities = 181/336 (53%), Positives = 249/336 (74%), Gaps = 2/336 (0%)
Query: 145 EMPWFPRKISDLDRAQN-VLMYGSELDADHPGFKDPIYRKRREQFAAIANNYKYGHPIPK 203
++PWFPRK+S+LD+ + V + +LD DHPGF D +YR+RR+ A IA Y++G PIP+
Sbjct: 193 KVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYRHGDPIPR 252
Query: 204 VQYTETEIKTWGIVFRELHKLYQKHACPEYLENWPQLVKYCGYREDNLPQLEDVSSFLKR 263
V+YT EI TW V+ L LY HAC E+LE + L ++ GYREDN+PQLEDVS FLK
Sbjct: 253 VEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNIPQLEDVSRFLKE 312
Query: 264 KTGFQLRPVAGYLSPRDFLSGLAFRVFHCTQYIRHSSDPFYTPEPDCCHELLGHMPLLAN 323
+TGFQLRPVAG LS RDFL+ LAFRVF CTQYIRH+S P ++PEPDCCHELLGH+P+LA+
Sbjct: 313 RTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLAD 372
Query: 324 PSFAQFSQELGLASLGASDADIDKLATLYFFTVEFGLCRQPDGSFCVYGAGLLSSVAELQ 383
+FAQFSQ++GLASLGASD +I+KL+TL +FTVEFGLC+Q +G YGAGLLSS EL
Sbjct: 373 RTFAQFSQDIGLASLGASDEEIEKLSTLSWFTVEFGLCKQ-NGEVKAYGAGLLSSYGELL 431
Query: 384 HALTTPEKIKRFDPDITVHEECIITSYQNAYYYTDSFEEAKEKMRAFAESIQRPFGVRYN 443
H L+ +I+ FDP+ + +YQ+ Y+ ++SF +AK+K+R++A IQRPF V+++
Sbjct: 432 HCLSEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYASRIQRPFSVKFD 491
Query: 444 PYTQSVEVLSNAQKITALVSELRGDLCIVSSAIKKI 479
PYT +++VL + Q + + ++ +L ++ A+ I
Sbjct: 492 PYTLAIDVLDSPQAVRRSLEGVQDELDTLAHALSAI 527
>AY196344-1|AAO72075.1| 163|Homo sapiens tryptophan hydroxylase
protein.
Length = 163
Score = 245 bits (600), Expect = 2e-64
Identities = 108/163 (66%), Positives = 139/163 (85%), Gaps = 1/163 (0%)
Query: 294 QYIRHSSDPFYTPEPDCCHELLGHMPLLANPSFAQFSQELGLASLGASDADIDKLATLYF 353
QY+RHSSDPFYTPEPD CHELLGH+PLLA PSFAQFSQE+GLASLGAS+ + KLAT YF
Sbjct: 1 QYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYF 60
Query: 354 FTVEFGLCRQPDGSFCVYGAGLLSSVAELQHALTTPEKIKRFDPDITVHEECIITSYQNA 413
FTVEFGLC+Q DG V+GAGLLSS++EL+HAL+ K+K FDP IT +EC+IT++Q+
Sbjct: 61 FTVEFGLCKQ-DGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDV 119
Query: 414 YYYTDSFEEAKEKMRAFAESIQRPFGVRYNPYTQSVEVLSNAQ 456
Y+ ++SFE+AKEKMR F ++I+RP GV+YNPYT+S+++L + +
Sbjct: 120 YFVSESFEDAKEKMREFTKTIKRPPGVKYNPYTRSIQILKDTK 162
>AY196345-1|AAO72074.1| 206|Homo sapiens tryptophan hydroxylase
protein.
Length = 206
Score = 221 bits (541), Expect = 3e-57
Identities = 110/205 (53%), Positives = 139/205 (67%), Gaps = 11/205 (5%)
Query: 45 ESERISVMFTLKNQVGGLVRALSVFQDLGINVLHIESRKSMTEVSSADILVDVECDPQRM 104
E R S++F+LKN+VGGL++AL +FQ+ +N+LHIESRKS S +I VD + + +++
Sbjct: 12 ERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQL 71
Query: 105 EQLKRMLKREVQDFEVVPPQTGDEFPPPTPMSAAASFDFGEMPWFPRKISDLDRAQN-VL 163
+ +LK V P D F +PWFP+KISDLD N VL
Sbjct: 72 NDILHLLKSHTNVLSVNLP---DNF-------TLKEDGMETVPWFPKKISDLDHCANRVL 121
Query: 164 MYGSELDADHPGFKDPIYRKRREQFAAIANNYKYGHPIPKVQYTETEIKTWGIVFRELHK 223
MYGSELDADHPGFKD +YRKRR+ FA +A NYK+G PIPKV++TE EIKTWG VF+EL+K
Sbjct: 122 MYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNK 181
Query: 224 LYQKHACPEYLENWPQLVKYCGYRE 248
LY HAC EYL+N P L KYCGYRE
Sbjct: 182 LYPTHACREYLKNLPLLSKYCGYRE 206
>DQ677337-1|ABG73365.1| 407|Homo sapiens tyrosine hydroxylase
isoform D2,8,9 protein.
Length = 407
Score = 186 bits (454), Expect = 1e-46
Identities = 90/205 (43%), Positives = 136/205 (66%), Gaps = 1/205 (0%)
Query: 275 YLSPRDFLSGLAFRVFHCTQYIRHSSDPFYTPEPDCCHELLGHMPLLANPSFAQFSQELG 334
Y R ++ +AF+ H R DCCHELLGH+P+LA+ +FAQFSQ++G
Sbjct: 203 YRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIATWDCCHELLGHVPMLADRTFAQFSQDIG 262
Query: 335 LASLGASDADIDKLATLYFFTVEFGLCRQPDGSFCVYGAGLLSSVAELQHALTTPEKIKR 394
LASLGASD +I+KL+TLY+FTVEFGLC+Q +G YGAGLLSS EL H L+ +I+
Sbjct: 263 LASLGASDEEIEKLSTLYWFTVEFGLCKQ-NGEVKAYGAGLLSSYGELLHCLSEEPEIRA 321
Query: 395 FDPDITVHEECIITSYQNAYYYTDSFEEAKEKMRAFAESIQRPFGVRYNPYTQSVEVLSN 454
FDP+ + +YQ+ Y+ ++SF +AK+K+R++A IQRPF V+++PYT +++VL +
Sbjct: 322 FDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYASRIQRPFSVKFDPYTLAIDVLDS 381
Query: 455 AQKITALVSELRGDLCIVSSAIKKI 479
Q + + ++ +L ++ A+ I
Sbjct: 382 PQAVRRSLEGVQDELDTLAHALSAI 406
Score = 90.6 bits (215), Expect = 1e-17
Identities = 37/71 (52%), Positives = 52/71 (73%), Gaps = 1/71 (1%)
Query: 145 EMPWFPRKISDLDRAQN-VLMYGSELDADHPGFKDPIYRKRREQFAAIANNYKYGHPIPK 203
++PWFPRK+S+LD+ + V + +LD DHPGF D +YR+RR+ A IA Y++G PIP+
Sbjct: 166 KVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYRHGDPIPR 225
Query: 204 VQYTETEIKTW 214
V+YT EI TW
Sbjct: 226 VEYTAEEIATW 236
>DQ677336-1|ABG73364.1| 403|Homo sapiens tyrosine hydroxylase
isoform D1b,2,8,9 protein.
Length = 403
Score = 186 bits (454), Expect = 1e-46
Identities = 90/205 (43%), Positives = 136/205 (66%), Gaps = 1/205 (0%)
Query: 275 YLSPRDFLSGLAFRVFHCTQYIRHSSDPFYTPEPDCCHELLGHMPLLANPSFAQFSQELG 334
Y R ++ +AF+ H R DCCHELLGH+P+LA+ +FAQFSQ++G
Sbjct: 199 YRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIATWDCCHELLGHVPMLADRTFAQFSQDIG 258
Query: 335 LASLGASDADIDKLATLYFFTVEFGLCRQPDGSFCVYGAGLLSSVAELQHALTTPEKIKR 394
LASLGASD +I+KL+TLY+FTVEFGLC+Q +G YGAGLLSS EL H L+ +I+
Sbjct: 259 LASLGASDEEIEKLSTLYWFTVEFGLCKQ-NGEVKAYGAGLLSSYGELLHCLSEEPEIRA 317
Query: 395 FDPDITVHEECIITSYQNAYYYTDSFEEAKEKMRAFAESIQRPFGVRYNPYTQSVEVLSN 454
FDP+ + +YQ+ Y+ ++SF +AK+K+R++A IQRPF V+++PYT +++VL +
Sbjct: 318 FDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYASRIQRPFSVKFDPYTLAIDVLDS 377
Query: 455 AQKITALVSELRGDLCIVSSAIKKI 479
Q + + ++ +L ++ A+ I
Sbjct: 378 PQAVRRSLEGVQDELDTLAHALSAI 402
Score = 90.6 bits (215), Expect = 1e-17
Identities = 37/71 (52%), Positives = 52/71 (73%), Gaps = 1/71 (1%)
Query: 145 EMPWFPRKISDLDRAQN-VLMYGSELDADHPGFKDPIYRKRREQFAAIANNYKYGHPIPK 203
++PWFPRK+S+LD+ + V + +LD DHPGF D +YR+RR+ A IA Y++G PIP+
Sbjct: 162 KVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYRHGDPIPR 221
Query: 204 VQYTETEIKTW 214
V+YT EI TW
Sbjct: 222 VEYTAEEIATW 232
>AK094614-1|BAC04385.1| 250|Homo sapiens protein ( Homo sapiens
cDNA FLJ37295 fis, clone BRAMY2015311, moderately
similar to TRYPTOPHAN 5-MONOOXYGENASE (EC 1.14.16.4). ).
Length = 250
Score = 147 bits (356), Expect = 9e-35
Identities = 78/183 (42%), Positives = 111/183 (60%), Gaps = 11/183 (6%)
Query: 17 GSDWQVKNESPHHPKLGELHAARVQAQAESERISVMFTLKNQVGGLVRALSVFQDLGINV 76
GS K S + G +++ +A ES + +V+F+LKN+VGGLV+AL +FQ+ +N+
Sbjct: 32 GSSTLNKPNSGKNDDKGNKGSSKREAATESGKTAVVFSLKNEVGGLVKALRLFQEKRVNM 91
Query: 77 LHIESRKSMTEVSSADILVDVECDPQRMEQLKRMLKREVQDFEVVPPQTGDEFPPPTPMS 136
+HIESRKS S +I VD EC +L ++LK + + PP+
Sbjct: 92 VHIESRKSRRRSSEVEIFVDCECGKTEFNELIQLLKFQTTIVTLNPPEN----------I 141
Query: 137 AAASFDFGEMPWFPRKISDLDRAQN-VLMYGSELDADHPGFKDPIYRKRREQFAAIANNY 195
+ ++PWFPRKIS+LD+ + VLMYGSELDADHPGFKD +YR+RR+ F +A Y
Sbjct: 142 WTEEEELEDVPWFPRKISELDKCSHRVLMYGSELDADHPGFKDNVYRQRRKYFVDVAMGY 201
Query: 196 KYG 198
KYG
Sbjct: 202 KYG 204
>BC106740-1|AAI06741.1| 206|Homo sapiens TPH1 protein protein.
Length = 206
Score = 137 bits (331), Expect = 1e-31
Identities = 73/156 (46%), Positives = 97/156 (62%), Gaps = 11/156 (7%)
Query: 45 ESERISVMFTLKNQVGGLVRALSVFQDLGINVLHIESRKSMTEVSSADILVDVECDPQRM 104
E R S++F+LKN+VGGL++AL +FQ+ +N+LHIESRKS S +I VD + + +++
Sbjct: 14 ERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQL 73
Query: 105 EQLKRMLKREVQDFEVVPPQTGDEFPPPTPMSAAASFDFGEMPWFPRKISDLDRAQN-VL 163
+ +LK V P D F +PWFP+KISDLD N VL
Sbjct: 74 NDIFHLLKSHTNVLSVNLP---DNF-------TLNEDGMETVPWFPKKISDLDHCANRVL 123
Query: 164 MYGSELDADHPGFKDPIYRKRREQFAAIANNYKYGH 199
MYGSELDADHPGFKD +YRKRR+ FA +A NYK +
Sbjct: 124 MYGSELDADHPGFKDNVYRKRRKYFADLAMNYKQAY 159
>AY144494-1|AAN39538.1| 115|Homo sapiens putative tyrosine
hydroxylase variant protein.
Length = 115
Score = 109 bits (263), Expect = 2e-23
Identities = 56/104 (53%), Positives = 72/104 (69%), Gaps = 1/104 (0%)
Query: 275 YLSPRDFLSGLAFRVFHCTQYIRHSSDPFYTPEPDCCHELLGHMPLLANPSFAQFSQELG 334
Y R ++ +AF+ H R DCCHELLGH+P+LA+ +FAQFSQ++G
Sbjct: 12 YRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIATWDCCHELLGHVPMLADRTFAQFSQDIG 71
Query: 335 LASLGASDADIDKLATLYFFTVEFGLCRQPDGSFCVYGAGLLSS 378
LASLGASD +I+KL+TL +FTVEFGLC+Q +G YGAGLLSS
Sbjct: 72 LASLGASDEEIEKLSTLSWFTVEFGLCKQ-NGEVKAYGAGLLSS 114
Score = 65.3 bits (152), Expect = 5e-10
Identities = 26/45 (57%), Positives = 33/45 (73%)
Query: 170 DADHPGFKDPIYRKRREQFAAIANNYKYGHPIPKVQYTETEIKTW 214
D DHPGF D +YR+RR+ A IA Y++G PIP+V+YT EI TW
Sbjct: 1 DLDHPGFSDQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIATW 45
>AY196346-1|AAO72076.1| 74|Homo sapiens tryptophan hydroxylase
protein.
Length = 74
Score = 95.9 bits (228), Expect = 3e-19
Identities = 38/73 (52%), Positives = 59/73 (80%)
Query: 384 HALTTPEKIKRFDPDITVHEECIITSYQNAYYYTDSFEEAKEKMRAFAESIQRPFGVRYN 443
HAL+ K+K FDP IT +EC+IT++Q+ Y+ ++SFE+AKEKMR ++I+RPFGV+YN
Sbjct: 1 HALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMRESTKTIKRPFGVKYN 60
Query: 444 PYTQSVEVLSNAQ 456
PYT+S+++L + +
Sbjct: 61 PYTRSIQILKDTK 73
>AF057280-2|AAC69458.1| 57|Homo sapiens tryptophan hydroxylase
isoform 1 protein.
Length = 57
Score = 64.9 bits (151), Expect = 6e-10
Identities = 26/55 (47%), Positives = 44/55 (80%)
Query: 430 FAESIQRPFGVRYNPYTQSVEVLSNAQKITALVSELRGDLCIVSSAIKKISAQDS 484
F ++I+RPFGV+YNPYT+S+++L + + IT+ ++EL+ DL +VS A+ K+S + S
Sbjct: 2 FTKTIKRPFGVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKVSRKPS 56
>AF057280-1|AAC69459.1| 79|Homo sapiens tryptophan hydroxylase
isoform 2 protein.
Length = 79
Score = 63.7 bits (148), Expect = 1e-09
Identities = 29/66 (43%), Positives = 47/66 (71%), Gaps = 1/66 (1%)
Query: 430 FAESIQRPFGVRYNPYTQSVEVLSNAQKITALVSELRGDLCIVSSAIKKISAQDSTLDVE 489
F ++I+RPFGV+YNPYT+S+++L + + IT+ ++EL+ DL +VS A+ K S + L V
Sbjct: 2 FTKTIKRPFGVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAK-SLNEDVLQVS 60
Query: 490 SIANML 495
A +L
Sbjct: 61 VFALLL 66
>AY144495-1|AAN39539.1| 44|Homo sapiens truncated tyrosine
hydroxylase protein.
Length = 44
Score = 60.9 bits (141), Expect = 1e-08
Identities = 25/44 (56%), Positives = 32/44 (72%)
Query: 170 DADHPGFKDPIYRKRREQFAAIANNYKYGHPIPKVQYTETEIKT 213
D DHPGF D +YR+RR+ A IA Y++G PIP+V+YT EI T
Sbjct: 1 DLDHPGFSDQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIAT 44
>AY563525-1|AAS66667.1| 18|Homo sapiens phenylalanine hydroxylase
protein.
Length = 18
Score = 38.3 bits (85), Expect = 0.062
Identities = 14/18 (77%), Positives = 14/18 (77%)
Query: 291 HCTQYIRHSSDPFYTPEP 308
HCTQYIRH S P YTP P
Sbjct: 1 HCTQYIRHGSKPMYTPGP 18
>S61396-1|AAD13928.1| 26|Homo sapiens PAH protein.
Length = 26
Score = 37.5 bits (83), Expect = 0.11
Identities = 17/26 (65%), Positives = 20/26 (76%), Gaps = 1/26 (3%)
Query: 347 KLATLYFFTVEFGLCRQPDGSFCVYG 372
KLAT+Y+FTVEFG C+Q D S YG
Sbjct: 1 KLATIYWFTVEFGFCKQGD-SIKAYG 25
>X81479-1|CAA57232.1| 886|Homo sapiens EMR1 protein.
Length = 886
Score = 36.3 bits (80), Expect = 0.25
Identities = 23/87 (26%), Positives = 32/87 (36%), Gaps = 2/87 (2%)
Query: 296 IRHSSDPFYTPEPDCCHELLGHMPLLANPSFAQFSQELGLASLGASDADIDKLATLYFFT 355
+ +DP PE C+ +G+ NP F S L L AS DID+ +
Sbjct: 173 VNECADPRACPEHATCNNTVGNYSCFCNPGFESSSGHLSCQGLKASCEDIDECTEM--CP 230
Query: 356 VEFGLCRQPDGSFCVYGAGLLSSVAEL 382
+ P FC G S +L
Sbjct: 231 INSTCTNTPGSYFCTCHPGFAPSSGQL 257
>S75697-1|AAD14181.1| 26|Homo sapiens PAH protein.
Length = 26
Score = 36.3 bits (80), Expect = 0.25
Identities = 17/25 (68%), Positives = 18/25 (72%)
Query: 260 FLKRKTGFQLRPVAGYLSPRDFLSG 284
F+ TGF LRPVAG LS RDFL G
Sbjct: 2 FIPACTGFCLRPVAGLLSSRDFLGG 26
>DQ217942-1|ABB70739.1| 886|Homo sapiens EGF-like module containing
mucin-like hormone receptor-like 1 protein.
Length = 886
Score = 35.5 bits (78), Expect = 0.44
Identities = 23/83 (27%), Positives = 31/83 (37%), Gaps = 2/83 (2%)
Query: 300 SDPFYTPEPDCCHELLGHMPLLANPSFAQFSQELGLASLGASDADIDKLATLYFFTVEFG 359
+DP PE C+ +G+ NP F S L L AS DID+ + +
Sbjct: 177 ADPRACPEHATCNNTVGNYSCFCNPGFESSSGHLSFQGLKASCEDIDECTEM--CPINST 234
Query: 360 LCRQPDGSFCVYGAGLLSSVAEL 382
P FC G S +L
Sbjct: 235 CTNTPGSYFCTCHPGFAPSNGQL 257
>BC059395-1|AAH59395.1| 821|Homo sapiens EMR1 protein protein.
Length = 821
Score = 35.5 bits (78), Expect = 0.44
Identities = 23/83 (27%), Positives = 31/83 (37%), Gaps = 2/83 (2%)
Query: 300 SDPFYTPEPDCCHELLGHMPLLANPSFAQFSQELGLASLGASDADIDKLATLYFFTVEFG 359
+DP PE C+ +G+ NP F S L L AS DID+ + +
Sbjct: 177 ADPRACPEHATCNNTVGNYSCFCNPGFESSSGHLSFQGLKASCEDIDECTEM--CPINST 234
Query: 360 LCRQPDGSFCVYGAGLLSSVAEL 382
P FC G S +L
Sbjct: 235 CTNTPGSYFCTCHPGFAPSNGQL 257
>AK131562-1|BAD18695.1| 867|Homo sapiens protein ( Homo sapiens
cDNA FLJ16811 fis, clone THYMU3024602, highly similar
to Cell surface glycoprotein EMR1 precursor. ).
Length = 867
Score = 35.5 bits (78), Expect = 0.44
Identities = 23/83 (27%), Positives = 31/83 (37%), Gaps = 2/83 (2%)
Query: 300 SDPFYTPEPDCCHELLGHMPLLANPSFAQFSQELGLASLGASDADIDKLATLYFFTVEFG 359
+DP PE C+ +G+ NP F S L L AS DID+ + +
Sbjct: 125 ADPRACPEHATCNNTVGNYSCFCNPGFESSSGHLSFQGLKASCEDIDECTEM--CPINST 182
Query: 360 LCRQPDGSFCVYGAGLLSSVAEL 382
P FC G S +L
Sbjct: 183 CTNTPGSYFCTCHPGFAPSNGQL 205
>AB065918-1|BAC06133.1| 929|Homo sapiens seven transmembrane helix
receptor protein.
Length = 929
Score = 35.5 bits (78), Expect = 0.44
Identities = 23/83 (27%), Positives = 31/83 (37%), Gaps = 2/83 (2%)
Query: 300 SDPFYTPEPDCCHELLGHMPLLANPSFAQFSQELGLASLGASDADIDKLATLYFFTVEFG 359
+DP PE C+ +G+ NP F S L L AS DID+ + +
Sbjct: 195 ADPRACPEHATCNNTVGNYSCFCNPGFESSSGHLSFQGLKASCEDIDECTEM--CPINST 252
Query: 360 LCRQPDGSFCVYGAGLLSSVAEL 382
P FC G S +L
Sbjct: 253 CTNTPGSYFCTCHPGFAPSNGQL 275
>AF044578-1|AAD02338.1| 579|Homo sapiens putative DNA polymerase
protein.
Length = 579
Score = 33.5 bits (73), Expect = 1.8
Identities = 21/91 (23%), Positives = 46/91 (50%), Gaps = 3/91 (3%)
Query: 32 LGELHAARVQAQAESERISVMFTLKNQVGGLVRALSVFQDLGINVLHIESRKSMTEVSSA 91
L +HA Q +A++ER +V F ++ L + + + H + + + ++
Sbjct: 378 LPRIHAHDQQLRAQAERQAVNFVVQGSAADLCKLAMIHVFTAVAASHTLTARLVAQIHD- 436
Query: 92 DILVDVECDPQRMEQLKRMLKREVQDFEVVP 122
++L +VE DPQ + + +++R ++ E VP
Sbjct: 437 ELLFEVE-DPQ-IPECAALVRRTMESLEQVP 465
>S75699-1|AAD14182.1| 26|Homo sapiens PAH protein.
Length = 26
Score = 32.7 bits (71), Expect = 3.1
Identities = 15/25 (60%), Positives = 18/25 (72%)
Query: 260 FLKRKTGFQLRPVAGYLSPRDFLSG 284
F+ TGF+L+PVA LS RDFL G
Sbjct: 2 FIPACTGFRLQPVAVLLSSRDFLGG 26
>BC007216-1|AAH07216.1| 333|Homo sapiens C5orf4 protein protein.
Length = 333
Score = 32.7 bits (71), Expect = 3.1
Identities = 18/54 (33%), Positives = 24/54 (44%)
Query: 148 WFPRKISDLDRAQNVLMYGSELDADHPGFKDPIYRKRREQFAAIANNYKYGHPI 201
WF +++ + VL Y S HP F I++K E A I Y HPI
Sbjct: 170 WFLLELAIFTLIEEVLFYYSHRLLHHPTFYKKIHKKHHEWTAPIGVISLYAHPI 223
>BC004506-1|AAH04506.2| 299|Homo sapiens C5orf4 protein protein.
Length = 299
Score = 32.7 bits (71), Expect = 3.1
Identities = 18/54 (33%), Positives = 24/54 (44%)
Query: 148 WFPRKISDLDRAQNVLMYGSELDADHPGFKDPIYRKRREQFAAIANNYKYGHPI 201
WF +++ + VL Y S HP F I++K E A I Y HPI
Sbjct: 136 WFLLELAIFTLIEEVLFYYSHRLLHHPTFYKKIHKKHHEWTAPIGVISLYAHPI 189
>Z23024-1|CAA80560.1| 439|Homo sapiens rhoGAP protein protein.
Length = 439
Score = 32.3 bits (70), Expect = 4.1
Identities = 30/117 (25%), Positives = 48/117 (41%), Gaps = 6/117 (5%)
Query: 139 ASFDFGEMPWFPRKISDLDRAQNVLMYGSELDADHPGFKDPIYRKRREQFAAIANNYKYG 198
AS D E W ++ D ++ + EL H + DP Y R Q +A + KYG
Sbjct: 26 ASID--EKNWPSDEMPDFPKSDDSKSSSPEL-VTHLKWDDPYYDIARHQIVEVAGDDKYG 82
Query: 199 HPIPKVQYTETEIKTWGIVFRELHKLYQKHACPEYLE-NWPQLVKYCGYREDNLPQL 254
I + ++ + + Y KH +Y+E ++ L + G DN P L
Sbjct: 83 RKI--IVFSACRMPPSHQLDHSKLLGYLKHTLDQYVESDYTLLYLHHGLTSDNKPSL 137
>U02570-1|AAA16142.1| 462|Homo sapiens CDC42 GTPase-activating
protein protein.
Length = 462
Score = 32.3 bits (70), Expect = 4.1
Identities = 30/117 (25%), Positives = 48/117 (41%), Gaps = 6/117 (5%)
Query: 139 ASFDFGEMPWFPRKISDLDRAQNVLMYGSELDADHPGFKDPIYRKRREQFAAIANNYKYG 198
AS D E W ++ D ++ + EL H + DP Y R Q +A + KYG
Sbjct: 49 ASID--EKNWPSDEMPDFPKSDDSKSSSPEL-VTHLKWDDPYYDIARHQIVEVAGDDKYG 105
Query: 199 HPIPKVQYTETEIKTWGIVFRELHKLYQKHACPEYLE-NWPQLVKYCGYREDNLPQL 254
I + ++ + + Y KH +Y+E ++ L + G DN P L
Sbjct: 106 RKI--IVFSACRMPPSHQLDHSKLLGYLKHTLDQYVESDYTLLYLHHGLTSDNKPSL 160
>BC018118-1|AAH18118.1| 439|Homo sapiens Rho GTPase activating
protein 1 protein.
Length = 439
Score = 32.3 bits (70), Expect = 4.1
Identities = 30/117 (25%), Positives = 48/117 (41%), Gaps = 6/117 (5%)
Query: 139 ASFDFGEMPWFPRKISDLDRAQNVLMYGSELDADHPGFKDPIYRKRREQFAAIANNYKYG 198
AS D E W ++ D ++ + EL H + DP Y R Q +A + KYG
Sbjct: 26 ASID--EKNWPSDEMPDFPKSDDSKSSSPEL-VTHLKWDDPYYDIARHQIVEVAGDDKYG 82
Query: 199 HPIPKVQYTETEIKTWGIVFRELHKLYQKHACPEYLE-NWPQLVKYCGYREDNLPQL 254
I + ++ + + Y KH +Y+E ++ L + G DN P L
Sbjct: 83 RKI--IVFSACRMPPSHQLDHSKLLGYLKHTLDQYVESDYTLLYLHHGLTSDNKPSL 137
>AY722625-1|AAU11304.1| 17|Homo sapiens phenylalanine hydroxylase
protein.
Length = 17
Score = 31.1 bits (67), Expect = 9.5
Identities = 12/16 (75%), Positives = 14/16 (87%)
Query: 246 YREDNLPQLEDVSSFL 261
+ EDN+PQLEDVS FL
Sbjct: 1 FHEDNIPQLEDVSQFL 16
Database: human
Posted date: Oct 5, 2007 11:13 AM
Number of letters in database: 73,234,838
Number of sequences in database: 224,733
Lambda K H
0.320 0.135 0.409
Gapped
Lambda K H
0.279 0.0580 0.190
Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 74,849,358
Number of Sequences: 224733
Number of extensions: 3175281
Number of successful extensions: 7835
Number of sequences better than 10.0: 41
Number of HSP's better than 10.0 without gapping: 37
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 7734
Number of HSP's gapped (non-prelim): 60
length of query: 502
length of database: 73,234,838
effective HSP length: 93
effective length of query: 409
effective length of database: 52,334,669
effective search space: 21404879621
effective search space used: 21404879621
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.8 bits)
S2: 67 (31.1 bits)
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