Silkworm BLAST Result against human

BLASTP 2.2.12 [Aug-07-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= BGIBMGA000640-TA|BGIBMGA000640-PA|IPR001128|Cytochrome P450
         (441 letters)

Database: human 
           224,733 sequences; 73,234,838 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

BC096260-1|AAH96260.1|  431|Homo sapiens CYP2C18 protein protein.     157   1e-37
BC104909-1|AAI04910.1|  501|Homo sapiens cytochrome P450, family...   147   8e-35
BC104907-1|AAI04908.1|  501|Homo sapiens cytochrome P450, family...   147   8e-35
AY323817-1|AAQ23114.1|  501|Homo sapiens cytochrome P450 2R1 pro...   147   8e-35
BC132767-1|AAI32768.1|  544|Homo sapiens cytochrome P450, family...   145   2e-34
AY343323-1|AAQ21380.1|  544|Homo sapiens cytochrome P450 protein.     145   2e-34
BX538127-1|CAD98029.1|  310|Homo sapiens hypothetical protein pr...   130   1e-29
U37143-1|AAC50370.2|  502|Homo sapiens cytochrome P450 monooxyge...   129   2e-29
BC032594-1|AAH32594.1|  502|Homo sapiens cytochrome P450, family...   129   2e-29
AY426985-1|AAQ93356.1|  502|Homo sapiens cytochrome P450, family...   129   2e-29
AF272142-1|AAM44456.1|  502|Homo sapiens cytochrome P450 protein.     129   2e-29
AB080265-1|BAB85489.1|  502|Homo sapiens cytochrome P450 2J2 pro...   129   2e-29
BC067435-1|AAH67435.1|  493|Homo sapiens cytochrome P450, family...   128   4e-29
BC067433-1|AAH67433.1|  493|Homo sapiens cytochrome P450, family...   128   5e-29
J02843-1|AAA52155.1|  493|Homo sapiens protein ( Human cytochrom...   127   7e-29
J02625-1|AAA35743.1|  493|Homo sapiens protein ( Human cytochrom...   127   7e-29
DQ515958-1|ABF47105.1|  493|Homo sapiens cytochrome P450, family...   127   7e-29
DQ149222-1|AAZ77710.1|  493|Homo sapiens cytochrome P450 2E1 pro...   127   7e-29
AL161645-2|CAH70047.1|  493|Homo sapiens cytochrome P450, family...   127   7e-29
AF182276-1|AAF13601.1|  493|Homo sapiens cytochrome P450-2E1 pro...   127   7e-29
AF084225-1|AAD13753.1|  462|Homo sapiens cytochrome P450 2E1 pro...   127   7e-29
Y00498-1|CAA68550.1|  490|Homo sapiens IIC2 protein.                  124   8e-28
X51535-1|CAA35915.1|  210|Homo sapiens cytochrome P-450 HPH (120...   124   8e-28
M21942-1|AAA52161.1|  462|Homo sapiens CYP2C protein.                 124   8e-28
M17397-1|AAA35739.1|  490|Homo sapiens protein ( Human cytochrom...   124   8e-28
BC020596-1|AAH20596.1|  490|Homo sapiens cytochrome P450, family...   124   8e-28
AY514490-1|AAR89907.1|  490|Homo sapiens cytochrome P450, family...   124   8e-28
AL359672-5|CAH71307.1|  490|Homo sapiens cytochrome P450, family...   124   8e-28
S46963-1|AAB23864.2|  477|Homo sapiens cytochrome P-450 protein.      123   1e-27
M21940-1|AAA52159.1|  383|Homo sapiens CYP2C protein.                 123   1e-27
D00173-1|BAA00123.1|  487|Homo sapiens cytochrome P-450 protein.      123   1e-27
BC125054-1|AAI25055.1|  490|Homo sapiens cytochrome P450, family...   123   1e-27
AY702706-1|AAT94065.1|  490|Homo sapiens cytochrome P450, family...   123   1e-27
AY341248-1|AAP88931.1|  490|Homo sapiens cytochrome P450, family...   123   1e-27
AL359672-1|CAH71303.1|  490|Homo sapiens cytochrome P450, family...   123   1e-27
M21941-1|AAA52160.1|  480|Homo sapiens CYP2C protein.                 123   1e-27
BC025761-1|AAH25761.2|  490|Homo sapiens cytochrome P450, family...   123   1e-27
M21939-1|AAA52158.1|  485|Homo sapiens CYP2C protein.                 120   8e-27
M15331-1|AAA52157.1|  485|Homo sapiens CYP2C protein.                 120   8e-27
M33317-1|AAA52138.1|  494|Homo sapiens CYP2A protein.                 120   1e-26
DQ211353-1|ABB01370.1|  497|Homo sapiens cytochrome P450 2D6 pro...   120   1e-26
X08006-1|CAA30807.1|  497|Homo sapiens cytochrome P450 db1 protein.   120   1e-26
M33388-1|AAA53500.1|  497|Homo sapiens cytochrome P450 IID6 prot...   120   1e-26
M20403-1|AAA52153.1|  497|Homo sapiens CYP2D protein.                 120   1e-26
DQ282154-1|ABB77902.1|  497|Homo sapiens cytochrome P450 2D6 pro...   120   1e-26
DQ282151-1|ABB77899.1|  496|Homo sapiens cytochrome P450 2D6 pro...   120   1e-26
DQ282146-1|ABB77897.1|  497|Homo sapiens cytochrome P450 2D6 pro...   120   1e-26
DQ282145-1|ABB77896.1|  497|Homo sapiens cytochrome P450 2D6 pro...   120   1e-26
DQ282144-1|ABB77895.1|  497|Homo sapiens cytochrome P450 2D6 pro...   120   1e-26
BC117165-1|AAI17166.1|  494|Homo sapiens cytochrome P450, family...   120   1e-26
BC075024-1|AAH75024.1|  497|Homo sapiens cytochrome P450, family...   120   1e-26
BC075023-1|AAH75023.1|  497|Homo sapiens cytochrome P450, family...   120   1e-26
AY545216-1|AAS55001.1|  497|Homo sapiens cytochrome P4502D6 prot...   120   1e-26
M61854-1|AAB59426.1|  490|Homo sapiens cytochrome protein.            119   2e-26
M33189-1|AAA35737.1|  500|Homo sapiens protein ( Human debrisoqu...   119   2e-26
M29874-1|AAA52144.1|  491|Homo sapiens CYP2B protein.                 119   2e-26
M24499-1|AAA36403.1|  373|Homo sapiens cytochrome P450db1 protein.    119   2e-26
L39102-1|AAL31348.1|  217|Homo sapiens S-mephenytoin 4-hydroxyla...   119   2e-26
DQ298753-1|ABB84469.1|  491|Homo sapiens cytochrome P450, family...   119   2e-26
DQ282152-1|ABB77900.1|  497|Homo sapiens cytochrome P450 2D6 pro...   119   2e-26
DQ211354-2|ABB01372.1|  497|Homo sapiens cytochrome P450 2D6 pro...   119   2e-26
DQ211353-2|ABB01371.1|  497|Homo sapiens cytochrome P450 2D6 pro...   119   2e-26
BC067431-1|AAH67431.1|  491|Homo sapiens cytochrome P450, family...   119   2e-26
BC067430-1|AAH67430.1|  491|Homo sapiens cytochrome P450, family...   119   2e-26
AF182277-1|AAF13602.1|  491|Homo sapiens cytochrome P450-2B6 pro...   119   2e-26
AC023172-1|AAF32444.1|  491|Homo sapiens CYP2B6 protein.              119   2e-26
AB209492-1|BAD92729.1|  566|Homo sapiens Debrisoquine 4-hydroxyl...   119   2e-26
L07093-1|AAA36660.1|  468|Homo sapiens cytochrome P450 protein.       119   2e-26
AY796203-1|AAV41877.1|  490|Homo sapiens cytochrome P450, family...   119   2e-26
AL583836-2|CAH74068.1|  490|Homo sapiens cytochrome P450, family...   119   2e-26
AL133513-2|CAH73444.1|  490|Homo sapiens cytochrome P450, family...   119   2e-26
X65962-1|CAA46778.1|  356|Homo sapiens cytochrome P-450 II C pro...   118   3e-26
M61858-1|AAA52145.1|  370|Homo sapiens CYP2C17 protein.               118   3e-26
X13930-1|CAA32118.1|  494|Homo sapiens protein ( Human CYP2A4 mR...   118   5e-26
X13929-1|CAA32117.1|  448|Homo sapiens P-450 IIA3 protein (1 is ...   118   5e-26
M33318-1|AAA52067.1|  494|Homo sapiens CYP2A protein.                 118   5e-26
BC096256-1|AAH96256.1|  494|Homo sapiens cytochrome P450, family...   118   5e-26
BC096255-1|AAH96255.1|  494|Homo sapiens cytochrome P450, family...   118   5e-26
BC096254-1|AAH96254.1|  494|Homo sapiens cytochrome P450, family...   118   5e-26
BC096253-1|AAH96253.3|  494|Homo sapiens cytochrome P450, family...   118   5e-26
DQ282162-1|ABB77909.1|  500|Homo sapiens cytochrome P450 2D6 pro...   117   7e-26
DQ282160-1|ABB77908.1|  497|Homo sapiens cytochrome P450 2D6 pro...   117   7e-26
DQ282159-1|ABB77907.1|  497|Homo sapiens cytochrome P450 2D6 pro...   117   7e-26
DQ282158-1|ABB77906.1|  497|Homo sapiens cytochrome P450 2D6 pro...   117   7e-26
DQ282157-1|ABB77905.1|  497|Homo sapiens cytochrome P450 2D6 pro...   117   7e-26
DQ282156-1|ABB77904.1|  497|Homo sapiens cytochrome P450 2D6 pro...   117   7e-26
DQ282155-1|ABB77903.1|  497|Homo sapiens cytochrome P450 2D6 pro...   117   7e-26
DQ282147-1|ABB77898.1|  497|Homo sapiens cytochrome P450 2D6 pro...   117   7e-26
CR456430-1|CAG30316.1|  446|Homo sapiens CYP2D6 protein.              117   7e-26
BC126858-1|AAI26859.1|  497|Homo sapiens cytochrome P450, family...   117   7e-26
BC106757-1|AAI06758.1|  446|Homo sapiens cytochrome P450, family...   117   7e-26
BC067432-1|AAH67432.1|  497|Homo sapiens cytochrome P450, family...   117   7e-26
BC066877-1|AAH66877.1|  446|Homo sapiens CYP2D6 protein protein.      117   7e-26
DQ282153-1|ABB77901.1|  497|Homo sapiens cytochrome P450 2D6 pro...   117   1e-25
BC106758-1|AAI06759.1|  497|Homo sapiens cytochrome P450, family...   117   1e-25
AF372573-1|AAL69652.1|  495|Homo sapiens cytochrome P450 2F1 pro...   116   1e-25
X13897-1|CAA32097.1|  489|Homo sapiens protein ( Human mRNA for ...   116   2e-25
AY513608-1|AAR90939.1|  494|Homo sapiens cytochrome P450 2A13 va...   116   2e-25
AY513606-1|AAR90937.1|  494|Homo sapiens cytochrome P450 2A13 va...   116   2e-25
AY513605-1|AAR90936.1|  494|Homo sapiens cytochrome P450 2A13 va...   116   2e-25
AY513604-1|AAR90935.1|  494|Homo sapiens cytochrome P450 2A13 va...   116   2e-25
AF209774-1|AAG35775.1|  494|Homo sapiens cytochrome P450 2A13 pr...   116   2e-25
AY513609-1|AAR90940.1|  494|Homo sapiens cytochrome P450 2A13 va...   115   3e-25
AF182275-1|AAF13600.1|  494|Homo sapiens cytochrome P450-2A6 pro...   115   3e-25
M21550-1|AAA52063.1|  495|Homo sapiens CYP21 protein.                 115   4e-25
X58906-1|CAA41709.1|  495|Homo sapiens steroid 21-monooxygenase ...   114   5e-25
U22028-1|AAB40519.1|  494|Homo sapiens cytochrome P450 protein.       114   5e-25
J02906-1|AAA52156.1|  491|Homo sapiens CYP2F1 protein.                114   7e-25
BC033691-1|AAH33691.1|  504|Homo sapiens cytochrome P450, family...   114   7e-25
AY358603-1|AAQ88966.1|  504|Homo sapiens Cytochrome p450 protein.     114   7e-25
AF335278-1|AAK13498.1|  504|Homo sapiens cytochrome P450 2S1 pro...   114   7e-25
M28548-1|AAA52065.1|  495|Homo sapiens protein ( Human mutant 21...   113   9e-25
M26856-1|AAA52064.1|  495|Homo sapiens protein ( Human 21-hydrox...   113   9e-25
M13936-1|AAA59695.1|  494|Homo sapiens CYP21P protein.                113   9e-25
BX679671-8|CAM26071.1|  464|Homo sapiens cytochrome P450, family...   113   9e-25
BX679671-7|CAM26070.1|  494|Homo sapiens cytochrome P450, family...   113   9e-25
BC125182-1|AAI25183.1|  494|Homo sapiens cytochrome P450, family...   113   9e-25
BC125181-1|AAI25182.1|  495|Homo sapiens cytochrome P450, family...   113   9e-25
AM183951-1|CAJ75805.1|  494|Homo sapiens steroid 21-hydroxylase,...   113   9e-25
AM183947-1|CAJ75801.1|  494|Homo sapiens steroid 21-hydroxylase,...   113   9e-25
AM183946-1|CAJ75800.1|  494|Homo sapiens steroid 21-hydroxylase,...   113   9e-25
AM183945-1|CAJ75799.1|  494|Homo sapiens steroid 21-hydroxylase,...   113   9e-25
AM086565-1|CAJ31104.1|  494|Homo sapiens steroid 21-hydroxylase,...   113   9e-25
AM086564-1|CAJ31103.1|  494|Homo sapiens steroid 21-hydroxylase,...   113   9e-25
AL929593-2|CAI41778.1|  465|Homo sapiens cytochrome P450, family...   113   9e-25
AL929593-1|CAI41779.1|  495|Homo sapiens cytochrome P450, family...   113   9e-25
AL662849-19|CAI17480.1|  465|Homo sapiens cytochrome P450, famil...   113   9e-25
AL662849-18|CAI17479.1|  495|Homo sapiens cytochrome P450, famil...   113   9e-25
AL645922-24|CAI41754.1|  495|Homo sapiens cytochrome P450, famil...   113   9e-25
AL645922-23|CAI41755.1|  465|Homo sapiens cytochrome P450, famil...   113   9e-25
AL049547-7|CAB89301.1|  495|Homo sapiens dJ34F7.3 (cytochrome P4...   113   9e-25
AF077974-1|AAD45405.1|  403|Homo sapiens cytochrome P450 21-hydr...   113   9e-25
AF019413-2|AAB67982.1|  495|Homo sapiens cytochrome P450 21-hydr...   113   9e-25
AK027605-1|BAB55227.1|  564|Homo sapiens protein ( Homo sapiens ...   112   2e-24
M17252-1|AAA59985.1|  230|Homo sapiens CYP21 protein.                 112   3e-24
BT019979-1|AAV38782.1|  543|Homo sapiens cytochrome P450, family...   112   3e-24
AM183949-1|CAJ75803.1|  494|Homo sapiens steroid 21-hydroxylase,...   112   3e-24
AK054616-1|BAB70774.1|  465|Homo sapiens protein ( Homo sapiens ...   112   3e-24
X02612-1|CAA26458.1|  512|Homo sapiens cytochrome P(1)-450 protein.   111   4e-24
U56438-1|AAC50809.1|  543|Homo sapiens dioxin-inducible cytochro...   111   4e-24
U03688-1|AAA19567.1|  543|Homo sapiens cytochrome P450 protein.       111   4e-24
M63871-1|AAA59984.1|  508|Homo sapiens CYP17 protein.                 111   4e-24
M31153-1|AAA52140.1|  508|Homo sapiens CYP17 protein.                 111   4e-24
M19489-1|AAA36405.1|  508|Homo sapiens CYP17 protein.                 111   4e-24
M14564-1|AAA52151.1|  508|Homo sapiens CYP17 protein.                 111   4e-24
DQ530598-1|ABF50972.1|  508|Homo sapiens cytochrome P450, family...   111   4e-24
BT020001-1|AAV38804.1|  543|Homo sapiens cytochrome P450, family...   111   4e-24
BT020000-1|AAV38803.1|  508|Homo sapiens cytochrome P450, family...   111   4e-24
BC063388-1|AAH63388.1|  508|Homo sapiens cytochrome P450, family...   111   4e-24
BC062997-1|AAH62997.1|  508|Homo sapiens cytochrome P450, family...   111   4e-24
BC012049-1|AAH12049.1|  543|Homo sapiens cytochrome P450, family...   111   4e-24
AY393998-1|AAQ87875.1|  543|Homo sapiens cytochrome P450, family...   111   4e-24
AM183948-1|CAJ75802.1|  494|Homo sapiens steroid 21-hydroxylase ...   111   4e-24
AL358790-3|CAI52498.1|  508|Homo sapiens cytochrome P450, family...   111   4e-24
AF450132-1|AAM50512.1|  543|Homo sapiens cytochrome P450 CYP1B1 ...   111   4e-24
AC009229-2|AAY15039.1|  543|Homo sapiens unknown protein.             111   4e-24
X04300-1|CAA27843.1|  512|Homo sapiens P-450 c protein.               111   5e-24
M61856-1|AAB59356.1|  490|Homo sapiens cytochrome protein.            111   5e-24
EF094025-1|ABK41999.1|  512|Homo sapiens cytochrome P450, family...   111   5e-24
BC096258-1|AAH96258.1|  490|Homo sapiens cytochrome P450, family...   111   5e-24
BC096257-1|AAH96257.1|  490|Homo sapiens cytochrome P450, family...   111   5e-24
BC069666-1|AAH69666.1|  490|Homo sapiens cytochrome P450, family...   111   5e-24
BC023019-1|AAH23019.1|  512|Homo sapiens cytochrome P450, family...   111   5e-24
AY310359-1|AAQ76692.1|  484|Homo sapiens cytochrome P450 1A1 var...   111   5e-24
AM236047-1|CAJ84704.1|  251|Homo sapiens cytochrome P450 1A1 pro...   111   5e-24
AL583836-1|CAH74067.1|  490|Homo sapiens cytochrome P450, family...   111   5e-24
AK223510-1|BAD97230.1|  490|Homo sapiens cytochrome P450, family...   111   5e-24
AK223113-1|BAD96833.1|  512|Homo sapiens cytochrome P450, family...   111   5e-24
AF253322-1|AAK25727.1|  512|Homo sapiens cytochrome P450 protein.     111   5e-24
Z00036-1|CAA77335.1|  515|Homo sapiens protein ( Human mRNA for ...   111   6e-24
M55053-1|AAA52146.1|  515|Homo sapiens cytochrome P3-450 protein.     111   6e-24
M31667-1|AAA52163.1|  515|Homo sapiens CYP1A2 protein.                111   6e-24
M12792-1|AAB59440.1|  494|Homo sapiens steroid 21-hydroxylase pr...   111   6e-24
L00389-1|AAA35738.1|  516|Homo sapiens protein ( Human cytochrom...   111   6e-24
K03191-1|AAA52139.1|  512|Homo sapiens CYP1A1 protein.                111   6e-24
DQ022432-1|AAY26399.1|  516|Homo sapiens cytochrome P450, family...   111   6e-24
BC067428-1|AAH67428.1|  516|Homo sapiens cytochrome P450, family...   111   6e-24
BC067427-1|AAH67427.1|  516|Homo sapiens cytochrome P450, family...   111   6e-24
BC067426-1|AAH67426.1|  516|Homo sapiens cytochrome P450, family...   111   6e-24
BC067425-1|AAH67425.1|  516|Homo sapiens cytochrome P450, family...   111   6e-24
BC067424-1|AAH67424.1|  516|Homo sapiens cytochrome P450, family...   111   6e-24
AF253322-2|AAK25728.1|  516|Homo sapiens cytochrome P450 protein.     111   6e-24
AM183950-1|CAJ75804.1|  494|Homo sapiens steroid 21-hydroxylase,...   110   8e-24
AF182274-1|AAF13599.1|  516|Homo sapiens cytochrome P450-1A2 pro...   110   8e-24
BC067429-1|AAH67429.1|  516|Homo sapiens cytochrome P450, family...   110   1e-23
M12079-1|AAA52152.1|  191|Homo sapiens POR protein.                   109   1e-23
AK223108-1|BAD96828.1|  512|Homo sapiens cytochrome P450, family...   109   2e-23
L16876-1|AAA02630.1|  490|Homo sapiens cytochrome P-4502C18 prot...   109   3e-23
U22029-1|AAB40520.1|  494|Homo sapiens cytochrome P450 protein.       108   3e-23
U22027-1|AAB40518.1|  494|Homo sapiens cytochrome P450 protein.       107   8e-23
K03192-1|AAA52147.1|  331|Homo sapiens CYP1A1 protein.                106   1e-22
M12078-1|AAA52154.1|  192|Homo sapiens POR protein.                   105   3e-22
AB209700-1|BAD92937.1|  336|Homo sapiens cytochrome P450, family...   105   4e-22
L16883-1|AAD13467.1|  169|Homo sapiens cytochrome P-450 2C protein.    99   3e-20
DQ016495-1|AAY34975.1|  195|Homo sapiens cytochrome P450 1B1 pro...    99   3e-20
AY220845-1|AAO49806.1|  516|Homo sapiens cytochrome P450 protein.      98   5e-20
AK223008-1|BAD96728.1|  502|Homo sapiens cytochrome P450, family...    95   6e-19
J04813-1|AAA02993.1|  502|Homo sapiens cytochrome P450 PCN3 prot...    93   2e-18
BC033862-1|AAH33862.1|  502|Homo sapiens cytochrome P450, family...    93   2e-18
AC005020-1|AAS02016.1|  502|Homo sapiens unknown protein.              93   2e-18
D00408-1|BAA00310.1|  503|Homo sapiens cytochrome P-450 HFLa pro...    91   5e-18
BC096259-1|AAH96259.1|  443|Homo sapiens CYP2C18 protein protein.      91   5e-18
BC067436-1|AAH67436.1|  503|Homo sapiens cytochrome P450, family...    91   5e-18
AF315325-1|AAG48618.1|  535|Homo sapiens cytochrome P450 variant...    91   5e-18
AF280107-3|AAG32289.1|  503|Homo sapiens cytochrome P450 polypep...    91   5e-18
BC039307-1|AAH39307.1|  372|Homo sapiens FLJ16008 protein protein.     91   7e-18
AK131190-1|BAD18388.1|  372|Homo sapiens .-.-).  protein.              91   7e-18
AK127151-1|BAC86855.1|  146|Homo sapiens protein ( Homo sapiens ...    91   7e-18
AF182273-1|AAF13598.1|  503|Homo sapiens cytochrome P450-3A4 pro...    91   9e-18
M18907-1|AAA35745.1|  503|Homo sapiens protein ( Human P450 mRNA...    90   1e-17
DQ924960-1|ABI96208.1|  503|Homo sapiens cytochrome P450 family ...    90   1e-17
DQ005611-1|AAY16980.1|  503|Homo sapiens cytochrome P450, family...    90   1e-17
BC101631-1|AAI01632.1|  503|Homo sapiens cytochrome P450, subfam...    90   1e-17
BC069418-1|AAH69418.1|  503|Homo sapiens cytochrome P450, family...    90   1e-17
AJ563377-1|CAD91345.1|  353|Homo sapiens cytochrome P450 protein.      90   1e-17
AJ563376-2|CAD91645.1|  430|Homo sapiens cytochrome P450 protein.      90   1e-17
AJ563375-1|CAD91343.1|  503|Homo sapiens cytochrome P450 protein.      90   1e-17
AF280107-2|AAG32290.1|  503|Homo sapiens cytochrome P450 polypep...    90   1e-17
AF209389-1|AAF21034.1|  503|Homo sapiens cytochrome P450 IIIA4 p...    90   1e-17
BC035350-1|AAH35350.1|  524|Homo sapiens cytochrome P450, family...    90   2e-17
AY358977-1|AAQ89336.1|  524|Homo sapiens CYP4F12 protein.              90   2e-17
AY008841-1|AAG33247.1|  524|Homo sapiens cytochrome P450 isoform...    90   2e-17
AC004523-1|AAC11543.1|  458|Homo sapiens F22329_1 protein.             90   2e-17
AB035131-1|BAB18270.1|  524|Homo sapiens cytochrome P450 protein.      90   2e-17
AB035130-1|BAB18269.1|  524|Homo sapiens cytochrome P450 protein.      90   2e-17
X12387-1|CAA30944.1|  503|Homo sapiens protein ( Human mRNA for ...    89   2e-17
M13785-1|AAA35742.1|  504|Homo sapiens protein ( Human liver glu...    89   2e-17
D00003-1|BAA00001.1|  504|Homo sapiens cytochrome P-450 protein.       89   2e-17
AK000366-1|BAA91114.1|  408|Homo sapiens protein ( Homo sapiens ...    89   4e-17
M14096-1|AAA35744.1|  503|Homo sapiens protein ( Human cytochrom...    87   9e-17
J04449-1|AAA35747.1|  502|Homo sapiens cytochrome P450 nifedipin...    87   9e-17
AM233517-1|CAJ80720.1|  175|Homo sapiens cytochrome P450 1A1 pro...    87   9e-17
BC016853-1|AAH16853.1|  524|Homo sapiens CYP4F11 protein protein.      86   2e-16
AF236085-1|AAG15889.1|  524|Homo sapiens CYP4F11 protein.              86   2e-16
U02388-1|AAC50052.2|  520|Homo sapiens cytochrome P450 4F2 protein.    86   3e-16
BC067440-1|AAH67440.1|  520|Homo sapiens cytochrome P450, family...    86   3e-16
AB015306-1|BAA75823.1|  520|Homo sapiens Leukotriene B4 omega-hy...    86   3e-16
D26480-1|BAA05490.1|  520|Homo sapiens leukotriene B4 omega-hydr...    85   4e-16
BC067439-1|AAH67439.1|  520|Homo sapiens cytochrome P450, family...    85   4e-16
BC067437-1|AAH67437.1|  520|Homo sapiens cytochrome P450, family...    85   4e-16
AF467894-1|AAL67578.1|  520|Homo sapiens cytochrome P450, subfam...    85   4e-16
AC005336-1|AAC27730.1|  520|Homo sapiens CYP4F2 protein.               85   4e-16
AF133298-1|AAD49566.1|  520|Homo sapiens cytochrome P450 protein.      85   5e-16
S67623-1|AAB29308.1|  257|Homo sapiens 25-hydroxyvitamin D 24-hy...    83   3e-15
AY858838-1|AAW50795.1|  372|Homo sapiens vitamin D 24-hydroxylas...    83   3e-15
AL138805-3|CAB91829.1|  514|Homo sapiens cytochrome P450, family...    83   3e-15
AL138805-1|CAM27342.1|  372|Homo sapiens cytochrome P450, family...    83   3e-15
Y07508-1|CAA68807.1|  503|Homo sapiens protein ( Human mRNA for ...    82   4e-15
X13589-1|CAA31929.1|  503|Homo sapiens protein ( Human mRNA for ...    82   4e-15
M30804-1|AAA35728.1|  503|Homo sapiens protein ( Human aromatase...    82   4e-15
M28420-1|AAA52141.1|  419|Homo sapiens cytochrome P-450 aromatas...    82   4e-15
M22246-1|AAA35557.1|  503|Homo sapiens protein ( Human aromatase...    82   4e-15
M18856-1|AAA35556.1|  419|Homo sapiens protein ( Human aromatase...    82   4e-15
J04127-1|AAA52132.1|  503|Homo sapiens CYP19 protein.                  82   4e-15
DQ118405-1|AAZ23558.1|  503|Homo sapiens cytochrome P450 subfami...    82   4e-15
BC107785-1|AAI07786.1|  503|Homo sapiens cytochrome P450, family...    82   4e-15
BC035959-1|AAH35959.1|  503|Homo sapiens cytochrome P450, family...    82   4e-15
AY957953-1|AAX44046.1|  503|Homo sapiens cytochrome P450, family...    82   4e-15
L13286-1|AAA62379.1|  513|Homo sapiens 1,25-dihydroxyvitamin D3 ...    81   6e-15
AY792513-1|AAV40834.1|  520|Homo sapiens cytochrome P450, family...    80   1e-14
AJ877238-1|CAI47002.1|   97|Homo sapiens putative cytochrome P45...    80   1e-14
AF054821-1|AAC08589.1|  520|Homo sapiens cytochrome P-450 protein.     80   1e-14
BC109205-1|AAI09206.1|  512|Homo sapiens cytochrome P450, family...    80   2e-14
BC069443-1|AAH69443.1|  512|Homo sapiens cytochrome P450, family...    80   2e-14
AF252297-1|AAF76003.1|  512|Homo sapiens cytochrome P450 retinoi...    80   2e-14
AC007002-1|AAY14690.1|  512|Homo sapiens unknown protein.              80   2e-14
BC060857-1|AAH60857.1|  525|Homo sapiens cytochrome P450, family...    79   2e-14
AY422002-1|AAR31180.1|  525|Homo sapiens cytochrome P450 4V2 pro...    79   2e-14
AK126473-1|BAC86562.1|  503|Homo sapiens protein ( Homo sapiens ...    79   2e-14
AK122600-1|BAC85487.1|  525|Homo sapiens protein ( Homo sapiens ...    79   2e-14
D12620-1|BAA02144.1|  520|Homo sapiens cytochrome P-450LTBV prot...    79   3e-14
AB002461-1|BAA25991.1|  520|Homo sapiens leukotriene B4 omega-hy...    79   3e-14
AB002454-1|BAA25990.1|  520|Homo sapiens leukotriene B4 omega-hy...    79   3e-14
AY390424-1|AAQ92352.1|  503|Homo sapiens cytochrome P450 CYP3A43...    79   4e-14
BC100981-1|AAI00982.1|  393|Homo sapiens CYP3A43 protein protein.      78   7e-14
AY390425-1|AAQ92353.1|  503|Homo sapiens cytochrome P450 CYP3A43...    78   7e-14
AF337813-1|AAK38841.1|  503|Homo sapiens cytochrome P450 subfami...    78   7e-14
AF319634-1|AAK00325.1|  503|Homo sapiens cytochrome P450 CYP3A43...    78   7e-14
AF280108-1|AAG33009.1|  503|Homo sapiens cytochrome P450 subfami...    78   7e-14
AC011904-4|AAS07395.1|  503|Homo sapiens unknown protein.              78   7e-14
AF040259-1|AAD10199.1|  144|Homo sapiens cytochrome P450 1A1 pro...    77   2e-13
BC128535-1|AAI28536.1|  143|Homo sapiens LOC283480 protein protein.    76   2e-13
AY178622-1|AAO21126.1|  531|Homo sapiens steroid hydroxylase pro...    76   2e-13
X59812-1|CAA42481.1|  530|Homo sapiens Vitamin D3 25-hydroxylase...    76   3e-13
M62401-1|AAA52142.1|  531|Homo sapiens sterol 27-hydroxylase pro...    76   3e-13
BC051851-1|AAH51851.1|  531|Homo sapiens cytochrome P450, family...    76   3e-13
BC040430-1|AAH40430.1|  531|Homo sapiens cytochrome P450, family...    76   3e-13
S67581-1|AAB29503.1|  591|Homo sapiens fatty acid omega-hydroxyl...    75   4e-13
S67580-1|AAB29502.1|  519|Homo sapiens fatty acid omega-hydroxyl...    75   4e-13
AF280109-1|AAG33010.1|  504|Homo sapiens cytochrome P450 subfami...    75   4e-13
AC011904-5|AAS07394.1|  504|Homo sapiens unknown protein.              75   4e-13
AY280372-1|AAQ21368.1|  519|Homo sapiens cytochrome P450 4A22 pr...    75   5e-13
AY288916-1|AAP31972.1|  508|Homo sapiens cytochrome P450, family...    75   7e-13
AF256213-1|AAG00416.1|  508|Homo sapiens 25- hydroxyvitamin D-1-...    75   7e-13
AF246895-1|AAF64299.1|  508|Homo sapiens 25-hydroxyvitamin D-1-a...    75   7e-13
AF027152-1|AAC51854.1|  508|Homo sapiens P450 25-hydroxyvitamin ...    75   7e-13
AF020192-1|AAC51853.1|  508|Homo sapiens 25-hydroxyvitamin D-1-a...    75   7e-13
AB006987-1|BAA23418.1|  508|Homo sapiens 25-hydroxyvitamin D3 1-...    75   7e-13
AB005990-1|BAA22657.1|  508|Homo sapiens 25-hydroxyvitamin D3 1a...    75   7e-13
AB005989-1|BAA22656.1|  508|Homo sapiens 25-hydroxyvitamin D3 1a...    75   7e-13
AB005038-1|BAA23416.1|  508|Homo sapiens 25-hydroxyvitamin D3 1-...    75   7e-13
L04751-1|AAA58436.1|  519|Homo sapiens cytochrome P450 protein.        74   9e-13
D26481-1|BAA05491.1|  519|Homo sapiens fatty acids omega-hydroxy...    74   9e-13
D13705-1|BAA02864.1|  521|Homo sapiens fatty acid omega-hydroxyl...    74   9e-13
AY369778-1|AAQ56847.1|  519|Homo sapiens cytochrome P450, family...    74   9e-13
AY280371-1|AAQ21367.1|  519|Homo sapiens cytochrome P450 4A22K p...    74   9e-13
AL731892-3|CAH72778.1|  519|Homo sapiens cytochrome P450, family...    74   9e-13
AY359068-1|AAQ89427.1|  462|Homo sapiens P450-like protein protein.    73   2e-12
AF525488-1|AAO16078.1|  519|Homo sapiens cytochrome P450, subfam...    73   2e-12
X71480-1|CAA50586.1|  141|Homo sapiens cytochrome P450 protein.        73   3e-12
BC093022-1|AAH93022.1|  416|Homo sapiens CYP20A1 protein protein.      73   3e-12
BC033752-1|AAH33752.1|  462|Homo sapiens cytochrome P450, family...    73   3e-12
BC020616-1|AAH20616.1|  462|Homo sapiens cytochrome P450, family...    73   3e-12
AF183412-1|AAG09681.1|  435|Homo sapiens cytochrome P450 monooxy...    73   3e-12
M24667-1|AAA52148.1|  256|Homo sapiens steroid 11-beta-hydroxyla...    72   4e-12
AY358631-1|AAQ88994.1|  505|Homo sapiens EPSW3060 protein.             72   4e-12
AY262056-1|AAO89257.1|  505|Homo sapiens cytochrome P450 protein.      72   4e-12
AL450996-2|CAH71036.1|  505|Homo sapiens cytochrome P450, family...    72   4e-12
AL135960-6|CAI19734.1|  505|Homo sapiens cytochrome P450, family...    72   4e-12
X55764-1|CAA39290.1|  503|Homo sapiens protein ( Human mRNA for ...    72   5e-12
AJ563378-3|CAD91347.1|  173|Homo sapiens hypothetical protein pr...    72   5e-12
AJ563378-2|CAD91647.1|  160|Homo sapiens cytochrome P450 protein.      72   5e-12
BC093896-1|AAH93896.1|  531|Homo sapiens cytochrome P450, family...    71   6e-12
BC093894-1|AAH93894.1|  531|Homo sapiens cytochrome P450, family...    71   6e-12
BC069351-1|AAH69351.1|  531|Homo sapiens cytochrome P450, family...    71   6e-12
AK096820-1|BAC04868.1|  531|Homo sapiens protein ( Homo sapiens ...    71   6e-12
BC022539-1|AAH22539.1|  500|Homo sapiens cytochrome P450, family...    71   8e-12
AL135960-10|CAI19737.1|  519|Homo sapiens cytochrome P450, famil...    71   8e-12
AF208532-1|AAF76722.1|  519|Homo sapiens fatty acid omega-hydrox...    71   8e-12
AF094480-1|AAD41244.1|  500|Homo sapiens cholesterol 24-hydroxyl...    71   8e-12
AF478474-1|AAL84813.1|  503|Homo sapiens mutated cytochrome P-45...    71   1e-11
M32879-1|AAA52149.1|  503|Homo sapiens CYP11B1 protein.                70   1e-11
BC096287-1|AAH96287.1|  503|Homo sapiens cytochrome P450, family...    70   1e-11
BC096285-1|AAH96285.1|  574|Homo sapiens CYP11B1 protein protein.      70   1e-11
BC028102-1|AAH28102.1|  509|Homo sapiens cytochrome P450, family...    69   2e-11
AY358537-1|AAQ88901.1|  509|Homo sapiens EFSW1929 protein.             69   2e-11
AM040940-1|CAJ13826.1|  509|Homo sapiens cytochrome P450 protein.      69   2e-11
AL450996-1|CAH71035.1|  509|Homo sapiens cytochrome P450, family...    69   2e-11
AK131355-1|BAD18508.1|  508|Homo sapiens protein ( Homo sapiens ...    69   2e-11
AK098065-1|BAC05226.1|  509|Homo sapiens protein ( Homo sapiens ...    69   2e-11
AK091806-1|BAC03751.1|  444|Homo sapiens protein ( Homo sapiens ...    69   2e-11
AF233625-1|AAF99279.1|  534|Homo sapiens thromboxane synthase pr...    69   2e-11
AF233624-1|AAF99278.1|  534|Homo sapiens thromboxane synthase pr...    69   2e-11
M80647-1|AAA60618.1|  534|Homo sapiens thromboxane synthase prot...    69   3e-11
M17398-1|AAA35740.1|  393|Homo sapiens protein ( Human cytochrom...    69   3e-11
D34625-1|BAA07011.1|  533|Homo sapiens thromboxane synthase prot...    69   3e-11
BC041157-1|AAH41157.1|  534|Homo sapiens thromboxane A synthase ...    69   3e-11
BC014117-1|AAH14117.1|  466|Homo sapiens TBXAS1 protein protein.       69   3e-11
AK223466-1|BAD97186.1|  534|Homo sapiens thromboxane A synthase ...    69   3e-11
AF233621-1|AAF99275.1|  534|Homo sapiens thromboxane synthase pr...    69   3e-11
AF233620-1|AAF99274.1|  534|Homo sapiens thromboxane synthase pr...    69   3e-11
AF233619-1|AAF99273.1|  534|Homo sapiens thromboxane synthase pr...    69   3e-11
AF233618-1|AAF99272.1|  534|Homo sapiens thromboxane synthase pr...    69   3e-11
AF233617-1|AAF99271.1|  534|Homo sapiens thromboxane synthase pr...    69   3e-11
AF233616-1|AAF99270.1|  534|Homo sapiens thromboxane synthase pr...    69   3e-11
AF233615-1|AAF99269.1|  534|Homo sapiens thromboxane synthase pr...    69   3e-11
AM233518-1|CAJ80721.1|  157|Homo sapiens cytochrome P450 1A1 pro...    69   4e-11
AF233623-1|AAF99277.1|  534|Homo sapiens thromboxane synthase pr...    69   4e-11
BC041158-1|AAH41158.1|  455|Homo sapiens CYP4A11 protein protein.      68   6e-11
AL731892-4|CAH72779.1|  455|Homo sapiens cytochrome P450, family...    68   6e-11
M32881-1|AAA35741.1|  503|Homo sapiens protein ( Human steroid 1...    68   8e-11
AF233622-1|AAF99276.1|  534|Homo sapiens thromboxane synthase pr...    68   8e-11
BC032322-1|AAH32322.1|  509|Homo sapiens cytochrome P450, family...    67   1e-10
AY871801-1|AAX62803.1|  483|Homo sapiens cytochrome P450 family ...    67   1e-10
X54741-1|CAA38539.1|  503|Homo sapiens aldosterone  synthase (P-...    66   2e-10
U51692-1|AAC50951.1|  503|Homo sapiens lanosterol 14-alpha demet...    66   2e-10
U23942-1|AAB39951.1|  509|Homo sapiens lanosterol 14-demethylase...    66   2e-10
D55653-1|BAA09512.1|  509|Homo sapiens lanosterol 14-demethylase...    66   2e-10
D13752-1|BAA02899.1|  503|Homo sapiens steroid 18-hydroxylase pr...    66   2e-10
AC000120-2|AAB46356.1|  509|Homo sapiens unknown protein.              66   2e-10
L16880-1|AAD13466.1|  273|Homo sapiens cytochrome P-450 2C protein.    65   4e-10
AF144566-1|AAD30164.1|  339|Homo sapiens cytochrome P450 epoxyge...    65   4e-10
AL135960-11|CAI19738.1|  455|Homo sapiens cytochrome P450, famil...    65   5e-10
X05367-1|CAA28965.1|  521|Homo sapiens desmolase protein.              62   3e-09
M28253-1|AAA36404.1|  239|Homo sapiens cytochrome P-450-scc prot...    62   3e-09
M14565-1|AAA52162.1|  521|Homo sapiens CYP11A protein.                 62   3e-09
BC032329-1|AAH32329.1|  521|Homo sapiens cytochrome P450, family...    62   3e-09
BC109056-1|AAI09057.1|  320|Homo sapiens CYP2F1 protein protein.       62   4e-09
AY356349-1|AAQ55485.1|  522|Homo sapiens cytochrome P450 protein.      62   4e-09
AL358613-1|CAH72802.2|  522|Homo sapiens cytochrome P450, family...    62   4e-09
AF491285-1|AAM09532.1|  511|Homo sapiens cytochrome P450 protein.      61   7e-09
L39098-1|AAL31347.1|  160|Homo sapiens S-mephenytoin 4-hydroxyla...    61   9e-09
AK090886-1|BAC03539.1|  337|Homo sapiens protein ( Homo sapiens ...    61   9e-09
X16699-1|CAA34672.1|  511|Homo sapiens protein ( Human mRNA for ...    60   1e-08
J02871-1|AAA35712.1|  511|Homo sapiens protein ( Human lung cyto...    60   1e-08
DQ518907-1|ABF47106.1|  511|Homo sapiens cytochrome P450, family...    60   1e-08
BC017758-1|AAH17758.1|  512|Homo sapiens cytochrome P450, family...    60   1e-08
AY151049-1|AAN72312.1|  497|Homo sapiens pulmonary cytochrome P4...    60   1e-08
AY151048-1|AAN72311.1|  512|Homo sapiens pulmonary cytochrome P4...    60   1e-08
AY064485-1|AAL57720.1|  511|Homo sapiens cytochrome P450 protein.      60   1e-08
AL593856-7|CAI16983.1|  497|Homo sapiens cytochrome P450, family...    60   1e-08
AL593856-6|CAI16982.1|  512|Homo sapiens cytochrome P450, family...    60   1e-08
AL593856-5|CAI16981.1|  511|Homo sapiens cytochrome P450, family...    60   1e-08
AL356793-4|CAI22559.1|  511|Homo sapiens cytochrome P450, family...    60   1e-08
AL356793-3|CAI22557.1|  512|Homo sapiens cytochrome P450, family...    60   1e-08
AL356793-2|CAI22558.1|  497|Homo sapiens cytochrome P450, family...    60   1e-08
BC020754-1|AAH20754.1|  162|Homo sapiens CYP2C9 protein protein.       60   2e-08
AY064486-1|AAL57721.1|  511|Homo sapiens cytochrome P450 protein.      60   2e-08
AC011737-1|AAX88915.1|  382|Homo sapiens unknown protein.              60   2e-08
BC070317-1|AAH70317.1|  162|Homo sapiens CYP2C9 protein protein.       58   5e-08
AL358613-3|CAH72804.1|  428|Homo sapiens cytochrome P450, family...    58   6e-08
AL358613-2|CAH72803.1|  497|Homo sapiens cytochrome P450, family...    58   6e-08
AF005418-1|AAB88881.1|  497|Homo sapiens retinoic acid hydroxyla...    58   6e-08
S63426-1|ABB76283.1|  214|Homo sapiens (S)-mephenytoin hydroxyla...    57   1e-07
M29873-1|AAA52143.1|  377|Homo sapiens CYP2B protein.                  57   1e-07
BC041174-1|AAH41174.1|  377|Homo sapiens CYP2B7P1 protein protein.     57   1e-07
AF237982-1|AAF63329.1|  469|Homo sapiens oxysterol 7alpha-hydrox...    57   1e-07
BC100982-1|AAI00983.1|  280|Homo sapiens CYP3A43 protein protein.      56   2e-07
AF280110-1|AAG33011.1|  420|Homo sapiens cytochrome P450 subfami...    56   2e-07
BC010358-1|AAH10358.1|  469|Homo sapiens cytochrome P450, family...    55   4e-07
AL135960-9|CAI19736.1|  421|Homo sapiens cytochrome P450, family...    55   4e-07
AL591242-1|CAH73899.1|  469|Homo sapiens cytochrome P450, family...    55   6e-07
AL035670-1|CAI20276.1|  469|Homo sapiens cytochrome P450, family...    55   6e-07
X58904-1|CAA41707.1|  371|Homo sapiens steroid 21-monooxygenase ...    53   2e-06
X58902-1|CAA41706.1|  372|Homo sapiens steroid 21-monooxygenase ...    53   2e-06
X58900-1|CAA41704.1|  372|Homo sapiens steroid 21-monooxygenase ...    53   2e-06
X58899-1|CAA41703.1|  368|Homo sapiens steroid 21-monooxygenase ...    53   2e-06
X58898-1|CAA41702.1|  371|Homo sapiens steroid 21-monooxygenase ...    53   2e-06
M80646-1|AAA60617.1|  460|Homo sapiens thromboxane synthase prot...    52   5e-06
AK127234-1|BAC86895.1|  130|Homo sapiens ).  protein.                  51   7e-06
X56088-1|CAA39568.1|  504|Homo sapiens cholesterol  7-alpha-hydr...    51   9e-06
M93133-1|AAA58435.1|  504|Homo sapiens cholesterol 7-alpha hydro...    50   2e-05
BC112184-1|AAI12185.1|  504|Homo sapiens cytochrome P450, family...    50   2e-05
BC101777-1|AAI01778.1|  504|Homo sapiens cytochrome P450, family...    50   2e-05
BC109084-1|AAI09085.1|  448|Homo sapiens CYP24A1 protein protein.      48   5e-05
BC109083-1|AAI09084.1|  448|Homo sapiens CYP24A1 protein protein.      48   5e-05
AL138805-2|CAM27343.1|  448|Homo sapiens cytochrome P450, family...    48   5e-05
AM236046-1|CAJ84703.1|  229|Homo sapiens cytochrome P450 1A1 pro...    44   0.001
AM233520-1|CAJ80723.1|  189|Homo sapiens cytochrome P450 1A1 pro...    44   0.001
AM233519-1|CAJ80722.1|  189|Homo sapiens cytochrome P450 1A1 pro...    44   0.001
AY904366-1|AAW83816.1|   62|Homo sapiens cytochrome p4502C9 prot...    40   0.013
BC067442-1|AAH67442.1|  501|Homo sapiens cytochrome P450, family...    40   0.023
AF090320-1|AAD19877.1|  501|Homo sapiens sterol 12-alpha-hydroxy...    40   0.023
AF090318-1|AAC63037.1|  462|Homo sapiens sterol 12-alpha hydroxy...    40   0.023
BC067444-1|AAH67444.1|  501|Homo sapiens cytochrome P450, family...    39   0.040
BC067441-1|AAH67441.1|  501|Homo sapiens cytochrome P450, family...    39   0.040
BC067434-1|AAH67434.1|  501|Homo sapiens cytochrome P450, family...    39   0.040
D50111-1|BAA08796.1|   46|Homo sapiens CYP2EI protein.                 38   0.053
AF176805-1|AAK11850.1|  506|Homo sapiens oxysterol 7alpha-hydrox...    38   0.053
AF127090-1|AAD20021.1|  506|Homo sapiens oxysterol 7alpha-hydrox...    38   0.053
AF029403-1|AAC95426.1|  506|Homo sapiens oxysterol 7alpha-hydrox...    38   0.053
BC029155-1|AAH29155.1|  489|Homo sapiens Unknown (protein for IM...    37   0.16 
DQ915490-1|ABI95134.1|   58|Homo sapiens cytochrome P4502D6 prot...    36   0.38 
DQ915489-1|ABI95133.1|   58|Homo sapiens cytochrome P4502D6 prot...    35   0.66 
DQ915488-1|ABI95132.1|   58|Homo sapiens cytochrome P4502D6 prot...    35   0.66 
DQ915487-1|ABI95131.1|   58|Homo sapiens cytochrome P4502D6 prot...    35   0.66 
DQ915486-1|ABI95130.1|   58|Homo sapiens cytochrome P4502D6 prot...    35   0.66 
DQ915485-1|ABI95129.1|   58|Homo sapiens cytochrome P4502D6 prot...    35   0.66 
D84124-1|BAA28219.1|  509|Homo sapiens prostacyclin synthase pro...    34   0.87 
D83402-1|BAA11910.1|  500|Homo sapiens prostacyclin synthase pro...    34   0.87 
D38145-1|BAA07343.1|  500|Homo sapiens prostacyclin synthase pro...    34   0.87 
BC101811-1|AAI01812.1|  500|Homo sapiens prostaglandin I2 (prost...    34   0.87 
BC101809-1|AAI01810.1|  500|Homo sapiens prostaglandin I2 (prost...    34   0.87 
AL118525-1|CAC14162.1|  500|Homo sapiens prostaglandin I2 (prost...    34   0.87 
AF297052-1|AAG31785.1|  500|Homo sapiens prostacyclin synthase p...    34   0.87 
AF297051-1|AAG31784.1|  500|Homo sapiens prostacyclin synthase p...    34   0.87 
AF297050-1|AAG31783.1|  500|Homo sapiens prostacyclin synthase p...    34   0.87 
AF297049-1|AAG31782.1|  500|Homo sapiens prostacyclin synthase p...    34   0.87 
AF297048-1|AAG31781.1|  500|Homo sapiens prostacyclin synthase p...    34   0.87 
BC041699-1|AAH41699.1|  659|Homo sapiens armadillo repeat contai...    33   1.5  
BC032661-1|AAH32661.1|  659|Homo sapiens armadillo repeat contai...    33   1.5  
AL096748-1|CAB46423.1|  242|Homo sapiens hypothetical protein pr...    33   1.5  
AK001882-1|BAA91959.1|  431|Homo sapiens protein ( Homo sapiens ...    33   1.5  
AJ563379-2|CAD91649.1|   84|Homo sapiens cytochrome P450 protein.      33   1.5  
Z15005-1|CAA78727.1| 2663|Homo sapiens CENP-E protein.                 32   3.5  
BC056258-1|AAH56258.1|  359|Homo sapiens CYP19A1 protein protein.      32   3.5  
BC020767-1|AAH20767.1|  360|Homo sapiens Unknown (protein for IM...    32   3.5  
S77873-1|AAD14267.1|   68|Homo sapiens CYP2E1 protein.                 32   4.6  

>BC096260-1|AAH96260.1|  431|Homo sapiens CYP2C18 protein protein.
          Length = 431

 Score =  157 bits (380), Expect = 1e-37
 Identities = 108/380 (28%), Positives = 181/380 (47%), Gaps = 17/380 (4%)

Query: 36  GPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKNVRQ 95
           GP   P  G+   + Q+  K  S  K+L   SK +   V  +  G + +VV++G + V++
Sbjct: 32  GPTPLPIIGN---ILQLDVKDMS--KSLTNFSKVYGP-VFTVYFGLKPIVVLHGYEAVKE 85

Query: 96  VFSE--SEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTSMEL 153
              +   EF GR +  F     + K LG+ F +G  W+E R+F +  L+N G GK S+E 
Sbjct: 86  ALIDHGEEFSGRGS--FPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIED 143

Query: 154 EIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERI--REDKLERLLELFYL 211
            +Q E + L E +      P     +   A  NV+   +  +R   ++ +   L+E F  
Sbjct: 144 RVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKFNE 203

Query: 212 RSKAFTLTGGLLSKIPWCRFIIPGLNDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKN 271
             +  +             F +  L   + TV  D+  AG++TT   +++ LL +L+   
Sbjct: 204 NLRILSSPWIQEKHNQQSEFTVESL---IATVT-DMFGAGTETTSTTLRYGLLLLLKYPE 259

Query: 272 IQEKIFNEIENTIG-DSMPCWADSSKLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDG 330
           +  K+  EIE  +G +  PC  D S + YT A + E+ R   + P   P  V  D     
Sbjct: 260 VTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKN 319

Query: 331 YVIPKETTVLISLADIHLDPNLWPDPHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGD 390
           Y+IPK TT++ SL  +  +   +P+P    P  F+D+ G  K +++  PF +G+R C G+
Sbjct: 320 YLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGE 379

Query: 391 SLARSFVFIIFVGILQKYRI 410
            LAR  +F+    ILQ + +
Sbjct: 380 GLARMELFLFLTTILQNFNL 399


>BC104909-1|AAI04910.1|  501|Homo sapiens cytochrome P450, family 2,
           subfamily R, polypeptide 1 protein.
          Length = 501

 Score =  147 bits (356), Expect = 8e-35
 Identities = 71/190 (37%), Positives = 109/190 (57%), Gaps = 1/190 (0%)

Query: 246 DLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSKLVYTSAFL 304
           +LIIAG++TT N +++A+L +    NIQ ++  EI+  +G +  P W D  K+ YT A L
Sbjct: 306 ELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVL 365

Query: 305 LEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERF 364
            EV+R   I PL       +D V+ GY IPK TTV+ +L  +H D   W DP    PERF
Sbjct: 366 HEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERF 425

Query: 365 IDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGVLPSNEADI 424
           +D  G     E + PF  GRR C G+ LAR  +F+ F  +LQ++ +   + ++P  +  +
Sbjct: 426 LDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRL 485

Query: 425 GLLAAPKPFV 434
           G+   P+P++
Sbjct: 486 GMTLQPQPYL 495



 Score = 60.1 bits (139), Expect = 2e-08
 Identities = 56/213 (26%), Positives = 92/213 (43%), Gaps = 14/213 (6%)

Query: 35  PGPIWYPFFGSS-SIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKNV 93
           PGP   PF G+  S+       H       +    Q   ++  L LG    VV+ G   V
Sbjct: 41  PGPPGLPFIGNIYSLAASSELPH-----VYMRKQSQVYGEIFSLDLGGISTVVLNGYDVV 95

Query: 94  RQ-VFSESE-FDGRPN-SFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTS 150
           ++ +  +SE F  RP    F K+  +G  L   +  G  W +HR+  V   +  G+G+ S
Sbjct: 96  KECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRG--WVDHRRLAVNSFRYFGYGQKS 153

Query: 151 MELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERI--REDKLERLLEL 208
            E +I  E K   + I   K +P     + ++AV N+    + GER    +   + ++EL
Sbjct: 154 FESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIEL 213

Query: 209 FYLRSK-AFTLTGGLLSKIPWCRFIIPGLNDQL 240
           F    + A + +  L +  PW   +  G + QL
Sbjct: 214 FSENVELAASASVFLYNAFPWIGILPFGKHQQL 246


>BC104907-1|AAI04908.1|  501|Homo sapiens cytochrome P450, family 2,
           subfamily R, polypeptide 1 protein.
          Length = 501

 Score =  147 bits (356), Expect = 8e-35
 Identities = 71/190 (37%), Positives = 109/190 (57%), Gaps = 1/190 (0%)

Query: 246 DLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSKLVYTSAFL 304
           +LIIAG++TT N +++A+L +    NIQ ++  EI+  +G +  P W D  K+ YT A L
Sbjct: 306 ELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVL 365

Query: 305 LEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERF 364
            EV+R   I PL       +D V+ GY IPK TTV+ +L  +H D   W DP    PERF
Sbjct: 366 HEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERF 425

Query: 365 IDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGVLPSNEADI 424
           +D  G     E + PF  GRR C G+ LAR  +F+ F  +LQ++ +   + ++P  +  +
Sbjct: 426 LDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRL 485

Query: 425 GLLAAPKPFV 434
           G+   P+P++
Sbjct: 486 GMTLQPQPYL 495



 Score = 60.1 bits (139), Expect = 2e-08
 Identities = 56/213 (26%), Positives = 92/213 (43%), Gaps = 14/213 (6%)

Query: 35  PGPIWYPFFGSS-SIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKNV 93
           PGP   PF G+  S+       H       +    Q   ++  L LG    VV+ G   V
Sbjct: 41  PGPPGLPFIGNIYSLAASSELPH-----VYMRKQSQVYGEIFSLDLGGISTVVLNGYDVV 95

Query: 94  RQ-VFSESE-FDGRPN-SFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTS 150
           ++ +  +SE F  RP    F K+  +G  L   +  G  W +HR+  V   +  G+G+ S
Sbjct: 96  KECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRG--WVDHRRLAVNSFRYFGYGQKS 153

Query: 151 MELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERI--REDKLERLLEL 208
            E +I  E K   + I   K +P     + ++AV N+    + GER    +   + ++EL
Sbjct: 154 FESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIEL 213

Query: 209 FYLRSK-AFTLTGGLLSKIPWCRFIIPGLNDQL 240
           F    + A + +  L +  PW   +  G + QL
Sbjct: 214 FSENVELAASASVFLYNAFPWIGILPFGKHQQL 246


>AY323817-1|AAQ23114.1|  501|Homo sapiens cytochrome P450 2R1
           protein.
          Length = 501

 Score =  147 bits (356), Expect = 8e-35
 Identities = 71/190 (37%), Positives = 109/190 (57%), Gaps = 1/190 (0%)

Query: 246 DLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSKLVYTSAFL 304
           +LIIAG++TT N +++A+L +    NIQ ++  EI+  +G +  P W D  K+ YT A L
Sbjct: 306 ELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVL 365

Query: 305 LEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERF 364
            EV+R   I PL       +D V+ GY IPK TTV+ +L  +H D   W DP    PERF
Sbjct: 366 HEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERF 425

Query: 365 IDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGVLPSNEADI 424
           +D  G     E + PF  GRR C G+ LAR  +F+ F  +LQ++ +   + ++P  +  +
Sbjct: 426 LDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRL 485

Query: 425 GLLAAPKPFV 434
           G+   P+P++
Sbjct: 486 GMTLQPQPYL 495



 Score = 60.1 bits (139), Expect = 2e-08
 Identities = 56/213 (26%), Positives = 92/213 (43%), Gaps = 14/213 (6%)

Query: 35  PGPIWYPFFGSS-SIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKNV 93
           PGP   PF G+  S+       H       +    Q   ++  L LG    VV+ G   V
Sbjct: 41  PGPPGLPFIGNIYSLAASSELPH-----VYMRKQSQVYGEIFSLDLGGISTVVLNGYDVV 95

Query: 94  RQ-VFSESE-FDGRPN-SFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTS 150
           ++ +  +SE F  RP    F K+  +G  L   +  G  W +HR+  V   +  G+G+ S
Sbjct: 96  KECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRG--WVDHRRLAVNSFRYFGYGQKS 153

Query: 151 MELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERI--REDKLERLLEL 208
            E +I  E K   + I   K +P     + ++AV N+    + GER    +   + ++EL
Sbjct: 154 FESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIEL 213

Query: 209 FYLRSK-AFTLTGGLLSKIPWCRFIIPGLNDQL 240
           F    + A + +  L +  PW   +  G + QL
Sbjct: 214 FSENVELAASASVFLYNAFPWIGILPFGKHQQL 246


>BC132767-1|AAI32768.1|  544|Homo sapiens cytochrome P450, family 2,
           subfamily U, polypeptide 1 protein.
          Length = 544

 Score =  145 bits (352), Expect = 2e-34
 Identities = 72/190 (37%), Positives = 109/190 (57%), Gaps = 2/190 (1%)

Query: 246 DLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSKLVYTSAFL 304
           DL IAG+ TT N++ + LL +  N ++QEK+  EIE  IG +  P   D +++ YT A +
Sbjct: 348 DLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDKAQMPYTEATI 407

Query: 305 LEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERF 364
           +EV R+  + PLA P    ++TV+ GY IPK T +L +L  +H DP +W  P +  P RF
Sbjct: 408 MEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPNRF 467

Query: 365 IDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDC-VNGVLPSNEAD 423
           +D++G     E   PFG G+R C G+ LA+  +F++FV ++Q +      +   P     
Sbjct: 468 LDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFALPEDSKKPLLTGR 527

Query: 424 IGLLAAPKPF 433
            GL  AP PF
Sbjct: 528 FGLTLAPHPF 537



 Score = 58.0 bits (134), Expect = 6e-08
 Identities = 47/176 (26%), Positives = 83/176 (47%), Gaps = 10/176 (5%)

Query: 79  LGRELVVVVYGEKNVRQVFSESE--FDGRPNSFFYKLRCLGKRLGVTFVD-GPLWREHRQ 135
           +G  LVVV+    +VR+   +    F  RP      +  + K  GV F   GP+WR+ R+
Sbjct: 122 IGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPLISI--VTKEKGVVFAHYGPVWRQQRK 179

Query: 136 FTVKHLKNVGFGKTSMELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGE 195
           F+   L++ G GK S+E +I  E K ++  +  +   P    S+ S+AV N++     G+
Sbjct: 180 FSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKHGEDPFCPFSIISNAVSNIICSLCFGQ 239

Query: 196 RI--REDKLERLLELFYLRSKAFTLTGG--LLSKIPWCRFIIPGLNDQLKTVCLDL 247
           R      + +++L  F  R     L     L++  PW  ++  G   +L+ +  D+
Sbjct: 240 RFDYTNSEFKKMLG-FMSRGLEICLNSQVLLVNICPWLYYLPFGPFKELRQIEKDI 294


>AY343323-1|AAQ21380.1|  544|Homo sapiens cytochrome P450 protein.
          Length = 544

 Score =  145 bits (352), Expect = 2e-34
 Identities = 72/190 (37%), Positives = 109/190 (57%), Gaps = 2/190 (1%)

Query: 246 DLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSKLVYTSAFL 304
           DL IAG+ TT N++ + LL +  N ++QEK+  EIE  IG +  P   D +++ YT A +
Sbjct: 348 DLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDKAQMPYTEATI 407

Query: 305 LEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERF 364
           +EV R+  + PLA P    ++TV+ GY IPK T +L +L  +H DP +W  P +  P RF
Sbjct: 408 MEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPNRF 467

Query: 365 IDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDC-VNGVLPSNEAD 423
           +D++G     E   PFG G+R C G+ LA+  +F++FV ++Q +      +   P     
Sbjct: 468 LDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFALPEDSKKPLLTGR 527

Query: 424 IGLLAAPKPF 433
            GL  AP PF
Sbjct: 528 FGLTLAPHPF 537



 Score = 58.0 bits (134), Expect = 6e-08
 Identities = 47/176 (26%), Positives = 83/176 (47%), Gaps = 10/176 (5%)

Query: 79  LGRELVVVVYGEKNVRQVFSESE--FDGRPNSFFYKLRCLGKRLGVTFVD-GPLWREHRQ 135
           +G  LVVV+    +VR+   +    F  RP      +  + K  GV F   GP+WR+ R+
Sbjct: 122 IGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPLISI--VTKEKGVVFAHYGPVWRQQRK 179

Query: 136 FTVKHLKNVGFGKTSMELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGE 195
           F+   L++ G GK S+E +I  E K ++  +  +   P    S+ S+AV N++     G+
Sbjct: 180 FSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKHGEDPFCPFSIISNAVSNIICSLCFGQ 239

Query: 196 RI--REDKLERLLELFYLRSKAFTLTGG--LLSKIPWCRFIIPGLNDQLKTVCLDL 247
           R      + +++L  F  R     L     L++  PW  ++  G   +L+ +  D+
Sbjct: 240 RFDYTNSEFKKMLG-FMSRGLEICLNSQVLLVNICPWLYYLPFGPFKELRQIEKDI 294


>BX538127-1|CAD98029.1|  310|Homo sapiens hypothetical protein
           protein.
          Length = 310

 Score =  130 bits (313), Expect = 1e-29
 Identities = 80/282 (28%), Positives = 134/282 (47%), Gaps = 7/282 (2%)

Query: 132 EHRQFTVKHLKNVGFGKTSMELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKY 191
           E R+F +  L+N G GK S+E  +Q E + L E +      P     +   A  NV+   
Sbjct: 1   EIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPAFILGCAPCNVICSV 60

Query: 192 VAGERI--REDKLERLLELFYLRSKAFTLTGGLLSKIPWCRFIIPGLNDQLKTVCLDLII 249
           +  +R   ++ +   L+E F    +  +             F +  L   + TV  D+  
Sbjct: 61  IFHDRFDYKDQRFLNLMEKFNENLRILSSPWIQEKHNQQSEFTVESL---IATVT-DMFG 116

Query: 250 AGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSKLVYTSAFLLEVM 308
           AG++TT   +++ LL +L+   +  K+  EIE  +G +  PC  D S + YT A + E+ 
Sbjct: 117 AGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQ 176

Query: 309 RIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERFIDEK 368
           R   + P   P  V  D     Y+IPK TT++ SL  +  +   +P+P    P  F+D+ 
Sbjct: 177 RYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKS 236

Query: 369 GLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRI 410
           G  K +++  PF +G+R C G+ LAR  +F+    ILQ + +
Sbjct: 237 GNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNL 278


>U37143-1|AAC50370.2|  502|Homo sapiens cytochrome P450
           monooxygenase CYP2J2 protein.
          Length = 502

 Score =  129 bits (312), Expect = 2e-29
 Identities = 70/187 (37%), Positives = 100/187 (53%), Gaps = 2/187 (1%)

Query: 245 LDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSM-PCWADSSKLVYTSAF 303
           LDL  AG++TT   +++ALL +     IQEK+  EI+  IG    P  A    + YT+A 
Sbjct: 306 LDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAV 365

Query: 304 LLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPER 363
           + EV R+  I PL  PR V  DT + GY +PK T +L +L  +H DP  W  P    P+ 
Sbjct: 366 IHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDH 425

Query: 364 FIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGVLPSNEAD 423
           F+ E G  K  E   PF  G+R C G+ LAR+ +FI F  ++QK+     N    S +  
Sbjct: 426 FL-ENGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSLKFR 484

Query: 424 IGLLAAP 430
           +G+  +P
Sbjct: 485 MGITISP 491



 Score = 66.9 bits (156), Expect = 1e-10
 Identities = 56/211 (26%), Positives = 97/211 (45%), Gaps = 13/211 (6%)

Query: 35  PGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKNVR 94
           PGP   PF G+  +V        S  +  L + K  +  +  L+LG    V++ G   ++
Sbjct: 45  PGPWRLPFLGNFFLVDF----EQSHLEVQLFVKKYGN--LFSLELGDISAVLITGLPLIK 98

Query: 95  Q--VFSESEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTSME 152
           +  +  +  F  RP +   +   + K+ G+    G  W+E R+FT+  L+N G GK S+E
Sbjct: 99  EALIHMDQNFGNRPVTPMREH--IFKKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLE 156

Query: 153 LEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERI--REDKLERLLELF- 209
             IQ E + L E I +   +P       ++AV N++     GER   ++   ++LL+L  
Sbjct: 157 ERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQLLKLLD 216

Query: 210 YLRSKAFTLTGGLLSKIPWCRFIIPGLNDQL 240
            +     + T  L +  PW    +PG +  L
Sbjct: 217 EVTYLEASKTCQLYNVFPWIMKFLPGPHQTL 247


>BC032594-1|AAH32594.1|  502|Homo sapiens cytochrome P450, family 2,
           subfamily J, polypeptide 2 protein.
          Length = 502

 Score =  129 bits (312), Expect = 2e-29
 Identities = 70/187 (37%), Positives = 100/187 (53%), Gaps = 2/187 (1%)

Query: 245 LDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSM-PCWADSSKLVYTSAF 303
           LDL  AG++TT   +++ALL +     IQEK+  EI+  IG    P  A    + YT+A 
Sbjct: 306 LDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAV 365

Query: 304 LLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPER 363
           + EV R+  I PL  PR V  DT + GY +PK T +L +L  +H DP  W  P    P+ 
Sbjct: 366 IHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDH 425

Query: 364 FIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGVLPSNEAD 423
           F+ E G  K  E   PF  G+R C G+ LAR+ +FI F  ++QK+     N    S +  
Sbjct: 426 FL-ENGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSLKFR 484

Query: 424 IGLLAAP 430
           +G+  +P
Sbjct: 485 MGITISP 491



 Score = 66.9 bits (156), Expect = 1e-10
 Identities = 56/211 (26%), Positives = 97/211 (45%), Gaps = 13/211 (6%)

Query: 35  PGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKNVR 94
           PGP   PF G+  +V        S  +  L + K  +  +  L+LG    V++ G   ++
Sbjct: 45  PGPWRLPFLGNFFLVDF----EQSHLEVQLFVKKYGN--LFSLELGDISAVLITGLPLIK 98

Query: 95  Q--VFSESEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTSME 152
           +  +  +  F  RP +   +   + K+ G+    G  W+E R+FT+  L+N G GK S+E
Sbjct: 99  EALIHMDQNFGNRPVTPMREH--IFKKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLE 156

Query: 153 LEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERI--REDKLERLLELF- 209
             IQ E + L E I +   +P       ++AV N++     GER   ++   ++LL+L  
Sbjct: 157 ERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQLLKLLD 216

Query: 210 YLRSKAFTLTGGLLSKIPWCRFIIPGLNDQL 240
            +     + T  L +  PW    +PG +  L
Sbjct: 217 EVTYLEASKTCQLYNVFPWIMKFLPGPHQTL 247


>AY426985-1|AAQ93356.1|  502|Homo sapiens cytochrome P450, family 2,
           subfamily J, polypeptide 2 protein.
          Length = 502

 Score =  129 bits (312), Expect = 2e-29
 Identities = 70/187 (37%), Positives = 100/187 (53%), Gaps = 2/187 (1%)

Query: 245 LDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSM-PCWADSSKLVYTSAF 303
           LDL  AG++TT   +++ALL +     IQEK+  EI+  IG    P  A    + YT+A 
Sbjct: 306 LDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAV 365

Query: 304 LLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPER 363
           + EV R+  I PL  PR V  DT + GY +PK T +L +L  +H DP  W  P    P+ 
Sbjct: 366 IHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDH 425

Query: 364 FIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGVLPSNEAD 423
           F+ E G  K  E   PF  G+R C G+ LAR+ +FI F  ++QK+     N    S +  
Sbjct: 426 FL-ENGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSLKFR 484

Query: 424 IGLLAAP 430
           +G+  +P
Sbjct: 485 MGITISP 491



 Score = 66.9 bits (156), Expect = 1e-10
 Identities = 56/211 (26%), Positives = 97/211 (45%), Gaps = 13/211 (6%)

Query: 35  PGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKNVR 94
           PGP   PF G+  +V        S  +  L + K  +  +  L+LG    V++ G   ++
Sbjct: 45  PGPWRLPFLGNFFLVDF----EQSHLEVQLFVKKYGN--LFSLELGDISAVLITGLPLIK 98

Query: 95  Q--VFSESEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTSME 152
           +  +  +  F  RP +   +   + K+ G+    G  W+E R+FT+  L+N G GK S+E
Sbjct: 99  EALIHMDQNFGNRPVTPMREH--IFKKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLE 156

Query: 153 LEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERI--REDKLERLLELF- 209
             IQ E + L E I +   +P       ++AV N++     GER   ++   ++LL+L  
Sbjct: 157 ERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQLLKLLD 216

Query: 210 YLRSKAFTLTGGLLSKIPWCRFIIPGLNDQL 240
            +     + T  L +  PW    +PG +  L
Sbjct: 217 EVTYLEASKTCQLYNVFPWIMKFLPGPHQTL 247


>AF272142-1|AAM44456.1|  502|Homo sapiens cytochrome P450 protein.
          Length = 502

 Score =  129 bits (312), Expect = 2e-29
 Identities = 70/187 (37%), Positives = 100/187 (53%), Gaps = 2/187 (1%)

Query: 245 LDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSM-PCWADSSKLVYTSAF 303
           LDL  AG++TT   +++ALL +     IQEK+  EI+  IG    P  A    + YT+A 
Sbjct: 306 LDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAV 365

Query: 304 LLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPER 363
           + EV R+  I PL  PR V  DT + GY +PK T +L +L  +H DP  W  P    P+ 
Sbjct: 366 IHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDH 425

Query: 364 FIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGVLPSNEAD 423
           F+ E G  K  E   PF  G+R C G+ LAR+ +FI F  ++QK+     N    S +  
Sbjct: 426 FL-ENGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSLKFR 484

Query: 424 IGLLAAP 430
           +G+  +P
Sbjct: 485 MGITISP 491



 Score = 66.9 bits (156), Expect = 1e-10
 Identities = 56/211 (26%), Positives = 97/211 (45%), Gaps = 13/211 (6%)

Query: 35  PGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKNVR 94
           PGP   PF G+  +V        S  +  L + K  +  +  L+LG    V++ G   ++
Sbjct: 45  PGPWRLPFLGNFFLVDF----EQSHLEVQLFVKKYGN--LFSLELGDISAVLITGLPLIK 98

Query: 95  Q--VFSESEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTSME 152
           +  +  +  F  RP +   +   + K+ G+    G  W+E R+FT+  L+N G GK S+E
Sbjct: 99  EALIHMDQNFGNRPVTPMREH--IFKKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLE 156

Query: 153 LEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERI--REDKLERLLELF- 209
             IQ E + L E I +   +P       ++AV N++     GER   ++   ++LL+L  
Sbjct: 157 ERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQLLKLLD 216

Query: 210 YLRSKAFTLTGGLLSKIPWCRFIIPGLNDQL 240
            +     + T  L +  PW    +PG +  L
Sbjct: 217 EVTYLEASKTCQLYNVFPWIMKFLPGPHQTL 247


>AB080265-1|BAB85489.1|  502|Homo sapiens cytochrome P450 2J2
           protein.
          Length = 502

 Score =  129 bits (311), Expect = 2e-29
 Identities = 70/187 (37%), Positives = 100/187 (53%), Gaps = 2/187 (1%)

Query: 245 LDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSM-PCWADSSKLVYTSAF 303
           LDL  AG++TT   +++ALL +     IQEK+  EI+  IG    P  A    + YT+A 
Sbjct: 306 LDLFFAGTETTSTTLRWALLYMALYPEIQEKVQVEIDRVIGQGQQPSTAARESMPYTNAV 365

Query: 304 LLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPER 363
           + EV R+  I PL  PR V  DT + GY +PK T +L +L  +H DP  W  P    P+ 
Sbjct: 366 IHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDH 425

Query: 364 FIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGVLPSNEAD 423
           F+ E G  K  E   PF  G+R C G+ LAR+ +FI F  ++QK+     N    S +  
Sbjct: 426 FL-ENGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSLKFR 484

Query: 424 IGLLAAP 430
           +G+  +P
Sbjct: 485 MGITISP 491



 Score = 66.9 bits (156), Expect = 1e-10
 Identities = 56/211 (26%), Positives = 97/211 (45%), Gaps = 13/211 (6%)

Query: 35  PGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKNVR 94
           PGP   PF G+  +V        S  +  L + K  +  +  L+LG    V++ G   ++
Sbjct: 45  PGPWRLPFLGNFFLVDF----EQSHLEVQLFVKKYGN--LFSLELGDISAVLITGLPLIK 98

Query: 95  Q--VFSESEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTSME 152
           +  +  +  F  RP +   +   + K+ G+    G  W+E R+FT+  L+N G GK S+E
Sbjct: 99  EALIHMDQNFGNRPVTPMREH--IFKKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLE 156

Query: 153 LEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERI--REDKLERLLELF- 209
             IQ E + L E I +   +P       ++AV N++     GER   ++   ++LL+L  
Sbjct: 157 ERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQLLKLLD 216

Query: 210 YLRSKAFTLTGGLLSKIPWCRFIIPGLNDQL 240
            +     + T  L +  PW    +PG +  L
Sbjct: 217 EVTYLEASKTCQLYNVFPWIMKFLPGPHQTL 247


>BC067435-1|AAH67435.1|  493|Homo sapiens cytochrome P450, family 2,
           subfamily E, polypeptide 1 protein.
          Length = 493

 Score =  128 bits (309), Expect = 4e-29
 Identities = 60/174 (34%), Positives = 100/174 (57%), Gaps = 1/174 (0%)

Query: 238 DQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDS-MPCWADSSK 296
           D +     DL  AG++TT   +++ LL +++   I+EK+  EI+  IG S +P   D  +
Sbjct: 287 DGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQE 346

Query: 297 LVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDP 356
           + Y  A + E+ R  T+ P   P    +DT+  GY+IPK T V+ +L  +  D   +PDP
Sbjct: 347 MPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDP 406

Query: 357 HEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRI 410
            + KPE F++E G  K +++  PF +G+R C G+ LAR+ +F++   ILQ + +
Sbjct: 407 EKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARTELFLLLCAILQHFNL 460



 Score = 65.7 bits (153), Expect = 3e-10
 Identities = 51/192 (26%), Positives = 92/192 (47%), Gaps = 12/192 (6%)

Query: 29  NQWFMAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVY 88
           + W + PGP   P  G+   + Q+  K+    K+   L++++   V  L +G + +VV++
Sbjct: 28  SSWNLPPGPFPLPIIGN---LFQLELKNIP--KSFTRLAQRFGP-VFTLYVGSQRMVVMH 81

Query: 89  GEKNVRQVFSE--SEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGF 146
           G K V++   +   EF GR +   +      +  G+ F +GP W++ R+F++  L+N G 
Sbjct: 82  GYKAVKEALLDYKDEFSGRGDLPAFHAH---RDRGIIFNNGPAWKDIRRFSLTTLRNYGM 138

Query: 147 GKTSMELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERIREDKLERLL 206
           GK   E  IQ E   L E +   + +P     +   A  NV+   +  +    +  E+ L
Sbjct: 139 GKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYND-EKFL 197

Query: 207 ELFYLRSKAFTL 218
            L YL ++ F L
Sbjct: 198 RLMYLFNENFHL 209


>BC067433-1|AAH67433.1|  493|Homo sapiens cytochrome P450, family 2,
           subfamily E, polypeptide 1 protein.
          Length = 493

 Score =  128 bits (308), Expect = 5e-29
 Identities = 60/174 (34%), Positives = 99/174 (56%), Gaps = 1/174 (0%)

Query: 238 DQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDS-MPCWADSSK 296
           D +     DL  AG++TT   +++ LL +++   I+EK+  EI+  IG S +P   D  +
Sbjct: 287 DGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQE 346

Query: 297 LVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDP 356
           + Y  A + E+ R  T+ P   P    +DT+  GY+IPK T V+ +L  +  D   +PDP
Sbjct: 347 MPYMDAVVREIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDP 406

Query: 357 HEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRI 410
            + KPE F++E G  K +++  PF +G+R C G+ LAR  +F++   ILQ + +
Sbjct: 407 EKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNL 460



 Score = 65.3 bits (152), Expect = 4e-10
 Identities = 51/192 (26%), Positives = 92/192 (47%), Gaps = 12/192 (6%)

Query: 29  NQWFMAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVY 88
           + W + PGP   P  G+   + Q+  K+    K+   L++++   V  L +G + +VV++
Sbjct: 28  SSWNLPPGPFPLPIIGN---LFQLELKNIP--KSFTRLAQRFGP-VFTLCVGSQRMVVMH 81

Query: 89  GEKNVRQVFSE--SEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGF 146
           G K V++   +   EF GR +   +      +  G+ F +GP W++ R+F++  L+N G 
Sbjct: 82  GYKAVKEALLDYKDEFSGRGDLPAFHAH---RDRGIIFNNGPTWKDIRRFSLTTLRNYGM 138

Query: 147 GKTSMELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERIREDKLERLL 206
           GK   E  IQ E   L E +   + +P     +   A  NV+   +  +    +  E+ L
Sbjct: 139 GKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYND-EKFL 197

Query: 207 ELFYLRSKAFTL 218
            L YL ++ F L
Sbjct: 198 RLMYLFNENFHL 209


>J02843-1|AAA52155.1|  493|Homo sapiens protein ( Human cytochrome
           P450IIE1 (ethanol-inducible) gene, complete cds. ).
          Length = 493

 Score =  127 bits (307), Expect = 7e-29
 Identities = 60/174 (34%), Positives = 99/174 (56%), Gaps = 1/174 (0%)

Query: 238 DQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDS-MPCWADSSK 296
           D +     DL  AG++TT   +++ LL +++   I+EK+  EI+  IG S +P   D  +
Sbjct: 287 DGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQE 346

Query: 297 LVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDP 356
           + Y  A + E+ R  T+ P   P    +DT+  GY+IPK T V+ +L  +  D   +PDP
Sbjct: 347 MPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDP 406

Query: 357 HEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRI 410
            + KPE F++E G  K +++  PF +G+R C G+ LAR  +F++   ILQ + +
Sbjct: 407 EKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNL 460



 Score = 65.7 bits (153), Expect = 3e-10
 Identities = 51/192 (26%), Positives = 92/192 (47%), Gaps = 12/192 (6%)

Query: 29  NQWFMAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVY 88
           + W + PGP   P  G+   + Q+  K+    K+   L++++   V  L +G + +VV++
Sbjct: 28  SSWNLPPGPFPLPIIGN---LFQLELKNIP--KSFTRLAQRFGP-VFTLYVGSQRMVVMH 81

Query: 89  GEKNVRQVFSE--SEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGF 146
           G K V++   +   EF GR +   +      +  G+ F +GP W++ R+F++  L+N G 
Sbjct: 82  GYKAVKEALLDYKDEFSGRGDLPAFHAH---RDRGIIFNNGPTWKDIRRFSLTTLRNYGM 138

Query: 147 GKTSMELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERIREDKLERLL 206
           GK   E  IQ E   L E +   + +P     +   A  NV+   +  +    +  E+ L
Sbjct: 139 GKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYND-EKFL 197

Query: 207 ELFYLRSKAFTL 218
            L YL ++ F L
Sbjct: 198 RLMYLFNENFHL 209


>J02625-1|AAA35743.1|  493|Homo sapiens protein ( Human cytochrome
           P-450j mRNA, complete cds. ).
          Length = 493

 Score =  127 bits (307), Expect = 7e-29
 Identities = 60/174 (34%), Positives = 99/174 (56%), Gaps = 1/174 (0%)

Query: 238 DQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDS-MPCWADSSK 296
           D +     DL  AG++TT   +++ LL +++   I+EK+  EI+  IG S +P   D  +
Sbjct: 287 DGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQE 346

Query: 297 LVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDP 356
           + Y  A + E+ R  T+ P   P    +DT+  GY+IPK T V+ +L  +  D   +PDP
Sbjct: 347 MPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDP 406

Query: 357 HEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRI 410
            + KPE F++E G  K +++  PF +G+R C G+ LAR  +F++   ILQ + +
Sbjct: 407 EKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNL 460



 Score = 65.7 bits (153), Expect = 3e-10
 Identities = 51/192 (26%), Positives = 92/192 (47%), Gaps = 12/192 (6%)

Query: 29  NQWFMAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVY 88
           + W + PGP   P  G+   + Q+  K+    K+   L++++   V  L +G + +VV++
Sbjct: 28  SSWNLPPGPFPLPIIGN---LFQLELKNIP--KSFTRLAQRFGP-VFTLYVGSQRMVVMH 81

Query: 89  GEKNVRQVFSE--SEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGF 146
           G K V++   +   EF GR +   +      +  G+ F +GP W++ R+F++  L+N G 
Sbjct: 82  GYKAVKEALLDYKDEFSGRGDLPAFHAH---RDRGIIFNNGPTWKDIRRFSLTTLRNYGM 138

Query: 147 GKTSMELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERIREDKLERLL 206
           GK   E  IQ E   L E +   + +P     +   A  NV+   +  +    +  E+ L
Sbjct: 139 GKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYND-EKFL 197

Query: 207 ELFYLRSKAFTL 218
            L YL ++ F L
Sbjct: 198 RLMYLFNENFHL 209


>DQ515958-1|ABF47105.1|  493|Homo sapiens cytochrome P450, family 2,
           subfamily E, polypeptide 1 protein.
          Length = 493

 Score =  127 bits (307), Expect = 7e-29
 Identities = 60/174 (34%), Positives = 99/174 (56%), Gaps = 1/174 (0%)

Query: 238 DQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDS-MPCWADSSK 296
           D +     DL  AG++TT   +++ LL +++   I+EK+  EI+  IG S +P   D  +
Sbjct: 287 DGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQE 346

Query: 297 LVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDP 356
           + Y  A + E+ R  T+ P   P    +DT+  GY+IPK T V+ +L  +  D   +PDP
Sbjct: 347 MPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDP 406

Query: 357 HEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRI 410
            + KPE F++E G  K +++  PF +G+R C G+ LAR  +F++   ILQ + +
Sbjct: 407 EKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNL 460



 Score = 65.7 bits (153), Expect = 3e-10
 Identities = 51/192 (26%), Positives = 92/192 (47%), Gaps = 12/192 (6%)

Query: 29  NQWFMAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVY 88
           + W + PGP   P  G+   + Q+  K+    K+   L++++   V  L +G + +VV++
Sbjct: 28  SSWNLPPGPFPLPIIGN---LFQLELKNIP--KSFTRLAQRFGP-VFTLYVGSQRMVVMH 81

Query: 89  GEKNVRQVFSE--SEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGF 146
           G K V++   +   EF GR +   +      +  G+ F +GP W++ R+F++  L+N G 
Sbjct: 82  GYKAVKEALLDYKDEFSGRGDLPAFHAH---RDRGIIFNNGPTWKDIRRFSLTTLRNYGM 138

Query: 147 GKTSMELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERIREDKLERLL 206
           GK   E  IQ E   L E +   + +P     +   A  NV+   +  +    +  E+ L
Sbjct: 139 GKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYND-EKFL 197

Query: 207 ELFYLRSKAFTL 218
            L YL ++ F L
Sbjct: 198 RLMYLFNENFHL 209


>DQ149222-1|AAZ77710.1|  493|Homo sapiens cytochrome P450 2E1
           protein.
          Length = 493

 Score =  127 bits (307), Expect = 7e-29
 Identities = 60/174 (34%), Positives = 99/174 (56%), Gaps = 1/174 (0%)

Query: 238 DQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDS-MPCWADSSK 296
           D +     DL  AG++TT   +++ LL +++   I+EK+  EI+  IG S +P   D  +
Sbjct: 287 DGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQE 346

Query: 297 LVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDP 356
           + Y  A + E+ R  T+ P   P    +DT+  GY+IPK T V+ +L  +  D   +PDP
Sbjct: 347 MPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDP 406

Query: 357 HEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRI 410
            + KPE F++E G  K +++  PF +G+R C G+ LAR  +F++   ILQ + +
Sbjct: 407 EKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNL 460



 Score = 65.7 bits (153), Expect = 3e-10
 Identities = 51/192 (26%), Positives = 92/192 (47%), Gaps = 12/192 (6%)

Query: 29  NQWFMAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVY 88
           + W + PGP   P  G+   + Q+  K+    K+   L++++   V  L +G + +VV++
Sbjct: 28  SSWNLPPGPFPLPIIGN---LFQLELKNIP--KSFTRLAQRFGP-VFTLYVGSQRMVVMH 81

Query: 89  GEKNVRQVFSE--SEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGF 146
           G K V++   +   EF GR +   +      +  G+ F +GP W++ R+F++  L+N G 
Sbjct: 82  GYKAVKEALLDYKDEFSGRGDLPAFHAH---RDRGIIFNNGPTWKDIRRFSLTTLRNYGM 138

Query: 147 GKTSMELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERIREDKLERLL 206
           GK   E  IQ E   L E +   + +P     +   A  NV+   +  +    +  E+ L
Sbjct: 139 GKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYND-EKFL 197

Query: 207 ELFYLRSKAFTL 218
            L YL ++ F L
Sbjct: 198 RLMYLFNENFHL 209


>AL161645-2|CAH70047.1|  493|Homo sapiens cytochrome P450, family 2,
           subfamily E, polypeptide 1 protein.
          Length = 493

 Score =  127 bits (307), Expect = 7e-29
 Identities = 60/174 (34%), Positives = 99/174 (56%), Gaps = 1/174 (0%)

Query: 238 DQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDS-MPCWADSSK 296
           D +     DL  AG++TT   +++ LL +++   I+EK+  EI+  IG S +P   D  +
Sbjct: 287 DGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQE 346

Query: 297 LVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDP 356
           + Y  A + E+ R  T+ P   P    +DT+  GY+IPK T V+ +L  +  D   +PDP
Sbjct: 347 MPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDP 406

Query: 357 HEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRI 410
            + KPE F++E G  K +++  PF +G+R C G+ LAR  +F++   ILQ + +
Sbjct: 407 EKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNL 460



 Score = 65.7 bits (153), Expect = 3e-10
 Identities = 51/192 (26%), Positives = 92/192 (47%), Gaps = 12/192 (6%)

Query: 29  NQWFMAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVY 88
           + W + PGP   P  G+   + Q+  K+    K+   L++++   V  L +G + +VV++
Sbjct: 28  SSWNLPPGPFPLPIIGN---LFQLELKNIP--KSFTRLAQRFGP-VFTLYVGSQRMVVMH 81

Query: 89  GEKNVRQVFSE--SEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGF 146
           G K V++   +   EF GR +   +      +  G+ F +GP W++ R+F++  L+N G 
Sbjct: 82  GYKAVKEALLDYKDEFSGRGDLPAFHAH---RDRGIIFNNGPTWKDIRRFSLTTLRNYGM 138

Query: 147 GKTSMELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERIREDKLERLL 206
           GK   E  IQ E   L E +   + +P     +   A  NV+   +  +    +  E+ L
Sbjct: 139 GKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYND-EKFL 197

Query: 207 ELFYLRSKAFTL 218
            L YL ++ F L
Sbjct: 198 RLMYLFNENFHL 209


>AF182276-1|AAF13601.1|  493|Homo sapiens cytochrome P450-2E1
           protein.
          Length = 493

 Score =  127 bits (307), Expect = 7e-29
 Identities = 60/174 (34%), Positives = 99/174 (56%), Gaps = 1/174 (0%)

Query: 238 DQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDS-MPCWADSSK 296
           D +     DL  AG++TT   +++ LL +++   I+EK+  EI+  IG S +P   D  +
Sbjct: 287 DGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQE 346

Query: 297 LVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDP 356
           + Y  A + E+ R  T+ P   P    +DT+  GY+IPK T V+ +L  +  D   +PDP
Sbjct: 347 MPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDP 406

Query: 357 HEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRI 410
            + KPE F++E G  K +++  PF +G+R C G+ LAR  +F++   ILQ + +
Sbjct: 407 EKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNL 460



 Score = 65.7 bits (153), Expect = 3e-10
 Identities = 51/192 (26%), Positives = 92/192 (47%), Gaps = 12/192 (6%)

Query: 29  NQWFMAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVY 88
           + W + PGP   P  G+   + Q+  K+    K+   L++++   V  L +G + +VV++
Sbjct: 28  SSWNLPPGPFPLPIIGN---LFQLELKNIP--KSFTRLAQRFGP-VFTLYVGSQRMVVMH 81

Query: 89  GEKNVRQVFSE--SEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGF 146
           G K V++   +   EF GR +   +      +  G+ F +GP W++ R+F++  L+N G 
Sbjct: 82  GYKAVKEALLDYKDEFSGRGDLPAFHAH---RDRGIIFNNGPTWKDIRRFSLTTLRNYGM 138

Query: 147 GKTSMELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERIREDKLERLL 206
           GK   E  IQ E   L E +   + +P     +   A  NV+   +  +    +  E+ L
Sbjct: 139 GKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYND-EKFL 197

Query: 207 ELFYLRSKAFTL 218
            L YL ++ F L
Sbjct: 198 RLMYLFNENFHL 209


>AF084225-1|AAD13753.1|  462|Homo sapiens cytochrome P450 2E1
           protein.
          Length = 462

 Score =  127 bits (307), Expect = 7e-29
 Identities = 60/174 (34%), Positives = 99/174 (56%), Gaps = 1/174 (0%)

Query: 238 DQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDS-MPCWADSSK 296
           D +     DL  AG++TT   +++ LL +++   I+EK+  EI+  IG S +P   D  +
Sbjct: 256 DGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQE 315

Query: 297 LVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDP 356
           + Y  A + E+ R  T+ P   P    +DT+  GY+IPK T V+ +L  +  D   +PDP
Sbjct: 316 MPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDP 375

Query: 357 HEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRI 410
            + KPE F++E G  K +++  PF +G+R C G+ LAR  +F++   ILQ + +
Sbjct: 376 EKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNL 429



 Score = 62.1 bits (144), Expect = 4e-09
 Identities = 50/188 (26%), Positives = 90/188 (47%), Gaps = 12/188 (6%)

Query: 33  MAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKN 92
           + PGP   P  G+   + Q+  K+    K+   L++++   V  L +G + +VV++G K 
Sbjct: 1   LPPGPFPLPIIGN---LFQLELKNIP--KSFTRLAQRFGP-VFTLYVGSQRMVVMHGYKA 54

Query: 93  VRQVFSE--SEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTS 150
           V++   +   EF GR +   +      +  G+ F +GP W++ R+F++  L+N G GK  
Sbjct: 55  VKEALLDYKDEFSGRGDLPAFHAH---RDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQG 111

Query: 151 MELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERIREDKLERLLELFY 210
            E  IQ E   L E +   + +P     +   A  NV+   +  +    +  E+ L L Y
Sbjct: 112 NESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYND-EKFLRLMY 170

Query: 211 LRSKAFTL 218
           L ++ F L
Sbjct: 171 LFNENFHL 178


>Y00498-1|CAA68550.1|  490|Homo sapiens IIC2 protein.
          Length = 490

 Score =  124 bits (298), Expect = 8e-28
 Identities = 61/196 (31%), Positives = 105/196 (53%), Gaps = 3/196 (1%)

Query: 246 DLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSKLVYTSAFL 304
           DL +AG++TT   +++ LL +L++  +  K+  EI++ IG    PC  D S + YT A +
Sbjct: 293 DLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVV 352

Query: 305 LEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERF 364
            E+ R   + P   P  V  DT    Y+IPK TT++  L  +  D   +P+P+   P  F
Sbjct: 353 HEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHF 412

Query: 365 IDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGVLPSNEADI 424
           +D+ G  K +++  PF +G+R C G+ LAR  +F+    ILQ + +  V+ +   N   +
Sbjct: 413 LDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAV 472

Query: 425 --GLLAAPKPFVANFV 438
             G+++ P  +   F+
Sbjct: 473 TKGIVSLPPSYQICFI 488



 Score = 59.3 bits (137), Expect = 3e-08
 Identities = 48/166 (28%), Positives = 77/166 (46%), Gaps = 10/166 (6%)

Query: 33  MAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKN 92
           + PGP   P  G+   + Q+  K     K+    SK +   V  +  G   +VV +G + 
Sbjct: 29  LPPGPTPLPIIGN---MLQIDVK--DICKSFTNFSKVYGP-VFTVYFGMNPIVVFHGYEA 82

Query: 93  VRQVFSES--EFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTS 150
           V++   ++  EF GR NS   +   + K LG+   +G  W+E R+F++  L+N G GK S
Sbjct: 83  VKEALIDNGEEFSGRGNSPISQR--ITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRS 140

Query: 151 MELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGER 196
           +E  +Q E   L E +   K  P     +   A  NV+   V  +R
Sbjct: 141 IEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKR 186


>X51535-1|CAA35915.1|  210|Homo sapiens cytochrome P-450 HPH (120
           AA) protein.
          Length = 210

 Score =  124 bits (298), Expect = 8e-28
 Identities = 61/196 (31%), Positives = 105/196 (53%), Gaps = 3/196 (1%)

Query: 246 DLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSKLVYTSAFL 304
           DL +AG++TT   +++ LL +L++  +  K+  EI++ IG    PC  D S + YT A +
Sbjct: 13  DLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVV 72

Query: 305 LEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERF 364
            E+ R   + P   P  V  DT    Y+IPK TT++  L  +  D   +P+P+   P  F
Sbjct: 73  HEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDREFPNPNIFDPGHF 132

Query: 365 IDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGVLPSNEADI 424
           +D+ G  K +++  PF +G+R C G+ LAR  +F+    ILQ + +  V+ +   N   +
Sbjct: 133 LDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAV 192

Query: 425 --GLLAAPKPFVANFV 438
             G+++ P  +   F+
Sbjct: 193 TKGIVSLPPSYQICFI 208


>M21942-1|AAA52161.1|  462|Homo sapiens CYP2C protein.
          Length = 462

 Score =  124 bits (298), Expect = 8e-28
 Identities = 61/196 (31%), Positives = 105/196 (53%), Gaps = 3/196 (1%)

Query: 246 DLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSKLVYTSAFL 304
           DL +AG++TT   +++ LL +L++  +  K+  EI++ IG    PC  D S + YT A +
Sbjct: 265 DLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVV 324

Query: 305 LEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERF 364
            E+ R   + P   P  V  DT    Y+IPK TT++  L  +  D   +P+P+   P  F
Sbjct: 325 HEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHF 384

Query: 365 IDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGVLPSNEADI 424
           +D+ G  K +++  PF +G+R C G+ LAR  +F+    ILQ + +  V+ +   N   +
Sbjct: 385 LDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAV 444

Query: 425 --GLLAAPKPFVANFV 438
             G+++ P  +   F+
Sbjct: 445 TKGIVSLPPSYQICFI 460



 Score = 58.0 bits (134), Expect = 6e-08
 Identities = 47/166 (28%), Positives = 77/166 (46%), Gaps = 10/166 (6%)

Query: 33  MAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKN 92
           + PGP   P  G+   + Q+  K     K+    SK +   V  +  G   +VV +G + 
Sbjct: 1   LPPGPTPLPIIGN---MLQIDVK--DICKSFTNFSKVYGP-VFTVYFGMNPIVVFHGYEA 54

Query: 93  VRQVFSES--EFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTS 150
           V++   ++  EF GR NS   +   + K LG+   +G  W+E R+F++  L+N G GK S
Sbjct: 55  VKEALIDNGEEFSGRGNSPISQR--ITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRS 112

Query: 151 MELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGER 196
           +E  +Q E   L + +   K  P     +   A  NV+   V  +R
Sbjct: 113 IEDRVQEEAHCLVDELRKTKASPCDPTFILGCAPCNVICSVVFQKR 158


>M17397-1|AAA35739.1|  490|Homo sapiens protein ( Human cytochrome
           P-450 1 functional form mRNA, complete cds. ).
          Length = 490

 Score =  124 bits (298), Expect = 8e-28
 Identities = 61/196 (31%), Positives = 105/196 (53%), Gaps = 3/196 (1%)

Query: 246 DLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSKLVYTSAFL 304
           DL +AG++TT   +++ LL +L++  +  K+  EI++ IG    PC  D S + YT A +
Sbjct: 293 DLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVV 352

Query: 305 LEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERF 364
            E+ R   + P   P  V  DT    Y+IPK TT++  L  +  D   +P+P+   P  F
Sbjct: 353 HEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHF 412

Query: 365 IDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGVLPSNEADI 424
           +D+ G  K +++  PF +G+R C G+ LAR  +F+    ILQ + +  V+ +   N   +
Sbjct: 413 LDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAV 472

Query: 425 --GLLAAPKPFVANFV 438
             G+++ P  +   F+
Sbjct: 473 TKGIVSLPPSYQICFI 488



 Score = 60.5 bits (140), Expect = 1e-08
 Identities = 48/166 (28%), Positives = 78/166 (46%), Gaps = 10/166 (6%)

Query: 33  MAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKN 92
           + PGP   P  G+   + Q+  K     K+    SK +   V  +  G   +VV +G + 
Sbjct: 29  LPPGPTPLPIIGN---MLQIDVK--DICKSFTNFSKVYGP-VFTVYFGMNPIVVFHGYEA 82

Query: 93  VRQVFSES--EFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTS 150
           V++   ++  EF GR NS   +   + K LG+   +G  W+E R+F++ +L+N G GK S
Sbjct: 83  VKEALIDNGEEFSGRGNSPISQR--ITKGLGIISSNGKRWKEIRRFSLTNLRNFGMGKRS 140

Query: 151 MELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGER 196
           +E  +Q E   L E +   K  P     +   A  NV+   V  +R
Sbjct: 141 IEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKR 186


>BC020596-1|AAH20596.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 8 protein.
          Length = 490

 Score =  124 bits (298), Expect = 8e-28
 Identities = 61/196 (31%), Positives = 105/196 (53%), Gaps = 3/196 (1%)

Query: 246 DLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSKLVYTSAFL 304
           DL +AG++TT   +++ LL +L++  +  K+  EI++ IG    PC  D S + YT A +
Sbjct: 293 DLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVV 352

Query: 305 LEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERF 364
            E+ R   + P   P  V  DT    Y+IPK TT++  L  +  D   +P+P+   P  F
Sbjct: 353 HEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHF 412

Query: 365 IDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGVLPSNEADI 424
           +D+ G  K +++  PF +G+R C G+ LAR  +F+    ILQ + +  V+ +   N   +
Sbjct: 413 LDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAV 472

Query: 425 --GLLAAPKPFVANFV 438
             G+++ P  +   F+
Sbjct: 473 TKGIVSLPPSYQICFI 488



 Score = 60.5 bits (140), Expect = 1e-08
 Identities = 48/166 (28%), Positives = 78/166 (46%), Gaps = 10/166 (6%)

Query: 33  MAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKN 92
           + PGP   P  G+   + Q+  K     K+    SK +   V  +  G   +VV +G ++
Sbjct: 29  LPPGPTPLPIIGN---MLQIDVK--DICKSFTNFSKVYGP-VFTVYFGMNPIVVFHGYES 82

Query: 93  VRQVFSES--EFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTS 150
           V++   ++  EF GR NS   +   + K LG+   +G  W+E R+F++  L+N G GK S
Sbjct: 83  VKEALIDNGEEFSGRGNSPISQR--ITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRS 140

Query: 151 MELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGER 196
           +E  +Q E   L E +   K  P     +   A  NV+   V  +R
Sbjct: 141 IEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKR 186


>AY514490-1|AAR89907.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 8 protein.
          Length = 490

 Score =  124 bits (298), Expect = 8e-28
 Identities = 61/196 (31%), Positives = 105/196 (53%), Gaps = 3/196 (1%)

Query: 246 DLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSKLVYTSAFL 304
           DL +AG++TT   +++ LL +L++  +  K+  EI++ IG    PC  D S + YT A +
Sbjct: 293 DLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVV 352

Query: 305 LEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERF 364
            E+ R   + P   P  V  DT    Y+IPK TT++  L  +  D   +P+P+   P  F
Sbjct: 353 HEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHF 412

Query: 365 IDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGVLPSNEADI 424
           +D+ G  K +++  PF +G+R C G+ LAR  +F+    ILQ + +  V+ +   N   +
Sbjct: 413 LDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAV 472

Query: 425 --GLLAAPKPFVANFV 438
             G+++ P  +   F+
Sbjct: 473 TKGIVSLPPSYQICFI 488



 Score = 59.3 bits (137), Expect = 3e-08
 Identities = 48/166 (28%), Positives = 77/166 (46%), Gaps = 10/166 (6%)

Query: 33  MAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKN 92
           + PGP   P  G+   + Q+  K     K+    SK +   V  +  G   +VV +G + 
Sbjct: 29  LPPGPTPLPIIGN---MLQIDVK--DICKSFTNFSKVYGP-VFTVYFGMNPIVVFHGYEA 82

Query: 93  VRQVFSES--EFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTS 150
           V++   ++  EF GR NS   +   + K LG+   +G  W+E R+F++  L+N G GK S
Sbjct: 83  VKEALIDNGEEFSGRGNSPISQR--ITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRS 140

Query: 151 MELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGER 196
           +E  +Q E   L E +   K  P     +   A  NV+   V  +R
Sbjct: 141 IEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKR 186


>AL359672-5|CAH71307.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 8 protein.
          Length = 490

 Score =  124 bits (298), Expect = 8e-28
 Identities = 61/196 (31%), Positives = 105/196 (53%), Gaps = 3/196 (1%)

Query: 246 DLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSKLVYTSAFL 304
           DL +AG++TT   +++ LL +L++  +  K+  EI++ IG    PC  D S + YT A +
Sbjct: 293 DLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVV 352

Query: 305 LEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERF 364
            E+ R   + P   P  V  DT    Y+IPK TT++  L  +  D   +P+P+   P  F
Sbjct: 353 HEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHF 412

Query: 365 IDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGVLPSNEADI 424
           +D+ G  K +++  PF +G+R C G+ LAR  +F+    ILQ + +  V+ +   N   +
Sbjct: 413 LDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAV 472

Query: 425 --GLLAAPKPFVANFV 438
             G+++ P  +   F+
Sbjct: 473 TKGIVSLPPSYQICFI 488



 Score = 59.3 bits (137), Expect = 3e-08
 Identities = 48/166 (28%), Positives = 77/166 (46%), Gaps = 10/166 (6%)

Query: 33  MAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKN 92
           + PGP   P  G+   + Q+  K     K+    SK +   V  +  G   +VV +G + 
Sbjct: 29  LPPGPTPLPIIGN---MLQIDVK--DICKSFTNFSKVYGP-VFTVYFGMNPIVVFHGYEA 82

Query: 93  VRQVFSES--EFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTS 150
           V++   ++  EF GR NS   +   + K LG+   +G  W+E R+F++  L+N G GK S
Sbjct: 83  VKEALIDNGEEFSGRGNSPISQR--ITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRS 140

Query: 151 MELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGER 196
           +E  +Q E   L E +   K  P     +   A  NV+   V  +R
Sbjct: 141 IEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKR 186


>S46963-1|AAB23864.2|  477|Homo sapiens cytochrome P-450 protein.
          Length = 477

 Score =  123 bits (297), Expect = 1e-27
 Identities = 62/174 (35%), Positives = 97/174 (55%), Gaps = 1/174 (0%)

Query: 238 DQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSK 296
           + L+   +DL  AG++TT   +++ALL +L++  +  K+  EIE  IG +  PC  D S 
Sbjct: 272 ESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSH 331

Query: 297 LVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDP 356
           + YT A + EV R   + P + P  V  D     Y+IPK TT+LISL  +  D   +P+P
Sbjct: 332 MPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNP 391

Query: 357 HEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRI 410
               P  F+DE G  K +++  PF +G+R C G++LA   +F+    ILQ + +
Sbjct: 392 EMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 445



 Score = 65.3 bits (152), Expect = 4e-10
 Identities = 49/166 (29%), Positives = 79/166 (47%), Gaps = 10/166 (6%)

Query: 33  MAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKN 92
           + PGP   P  G+   + Q+  K  S  K+L  LSK +   V  L  G + +VV++G + 
Sbjct: 16  LPPGPTPLPVIGN---ILQIGIKDIS--KSLTNLSKVYGP-VFTLYFGLKPIVVLHGYEA 69

Query: 93  VRQVFSE--SEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTS 150
           V++   +   EF GR    F       +  G+ F +G  W+E R+F++  L+N G GK S
Sbjct: 70  VKEALIDLGEEFSGR--GIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRS 127

Query: 151 MELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGER 196
           +E  +Q E + L E +   K  P     +   A  NV+   +  +R
Sbjct: 128 IEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKR 173


>M21940-1|AAA52159.1|  383|Homo sapiens CYP2C protein.
          Length = 383

 Score =  123 bits (297), Expect = 1e-27
 Identities = 62/174 (35%), Positives = 97/174 (55%), Gaps = 1/174 (0%)

Query: 238 DQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSK 296
           + L+   +DL  AG++TT   +++ALL +L++  +  K+  EIE  IG +  PC  D S 
Sbjct: 178 ESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSH 237

Query: 297 LVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDP 356
           + YT A + EV R   + P + P  V  D     Y+IPK TT+LISL  +  D   +P+P
Sbjct: 238 MPYTDAVVHEVQRCIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNP 297

Query: 357 HEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRI 410
               P  F+DE G  K +++  PF +G+R C G++LA   +F+    ILQ + +
Sbjct: 298 EMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 351



 Score = 49.2 bits (112), Expect = 3e-05
 Identities = 24/76 (31%), Positives = 39/76 (51%)

Query: 121 GVTFVDGPLWREHRQFTVKHLKNVGFGKTSMELEIQNELKLLREYINDNKHKPIKVDSMF 180
           G+ F +G  W+E R+F++  L+N G GK S+E  +Q E + L E +   K  P     + 
Sbjct: 4   GIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFIL 63

Query: 181 SSAVMNVLWKYVAGER 196
             A  NV+   +  +R
Sbjct: 64  GCAPCNVICSIIFHKR 79


>D00173-1|BAA00123.1|  487|Homo sapiens cytochrome P-450 protein.
          Length = 487

 Score =  123 bits (297), Expect = 1e-27
 Identities = 62/174 (35%), Positives = 97/174 (55%), Gaps = 1/174 (0%)

Query: 238 DQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSK 296
           + L+   +DL  AG++TT   +++ALL +L++  +  K+  EIE  IG +  PC  D S 
Sbjct: 282 ESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSH 341

Query: 297 LVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDP 356
           + YT A + EV R   + P + P  V  D     Y+IPK TT+LISL  +  D   +P+P
Sbjct: 342 MPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNP 401

Query: 357 HEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRI 410
               P  F+DE G  K +++  PF +G+R C G++LA   +F+    ILQ + +
Sbjct: 402 EMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 455



 Score = 65.3 bits (152), Expect = 4e-10
 Identities = 49/166 (29%), Positives = 79/166 (47%), Gaps = 10/166 (6%)

Query: 33  MAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKN 92
           + PGP   P  G+   + Q+  K  S  K+L  LSK +   V  L  G + +VV++G + 
Sbjct: 26  LPPGPTPLPVIGN---ILQIGIKDIS--KSLTNLSKVYGP-VFTLYFGLKPIVVLHGYEA 79

Query: 93  VRQVFSE--SEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTS 150
           V++   +   EF GR    F       +  G+ F +G  W+E R+F++  L+N G GK S
Sbjct: 80  VKEALIDLGEEFSGR--GIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRS 137

Query: 151 MELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGER 196
           +E  +Q E + L E +   K  P     +   A  NV+   +  +R
Sbjct: 138 IEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKR 183


>BC125054-1|AAI25055.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 9 protein.
          Length = 490

 Score =  123 bits (297), Expect = 1e-27
 Identities = 62/174 (35%), Positives = 97/174 (55%), Gaps = 1/174 (0%)

Query: 238 DQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSK 296
           + L+   +DL  AG++TT   +++ALL +L++  +  K+  EIE  IG +  PC  D S 
Sbjct: 285 ESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSH 344

Query: 297 LVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDP 356
           + YT A + EV R   + P + P  V  D     Y+IPK TT+LISL  +  D   +P+P
Sbjct: 345 MPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNP 404

Query: 357 HEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRI 410
               P  F+DE G  K +++  PF +G+R C G++LA   +F+    ILQ + +
Sbjct: 405 EMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 458



 Score = 65.3 bits (152), Expect = 4e-10
 Identities = 49/166 (29%), Positives = 79/166 (47%), Gaps = 10/166 (6%)

Query: 33  MAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKN 92
           + PGP   P  G+   + Q+  K  S  K+L  LSK +   V  L  G + +VV++G + 
Sbjct: 29  LPPGPTPLPVIGN---ILQIGIKDIS--KSLTNLSKVYGP-VFTLYFGLKPIVVLHGYEA 82

Query: 93  VRQVFSE--SEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTS 150
           V++   +   EF GR    F       +  G+ F +G  W+E R+F++  L+N G GK S
Sbjct: 83  VKEALIDLGEEFSGR--GIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRS 140

Query: 151 MELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGER 196
           +E  +Q E + L E +   K  P     +   A  NV+   +  +R
Sbjct: 141 IEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKR 186


>AY702706-1|AAT94065.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 9 protein.
          Length = 490

 Score =  123 bits (297), Expect = 1e-27
 Identities = 62/174 (35%), Positives = 97/174 (55%), Gaps = 1/174 (0%)

Query: 238 DQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSK 296
           + L+   +DL  AG++TT   +++ALL +L++  +  K+  EIE  IG +  PC  D S 
Sbjct: 285 ESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSH 344

Query: 297 LVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDP 356
           + YT A + EV R   + P + P  V  D     Y+IPK TT+LISL  +  D   +P+P
Sbjct: 345 MPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNP 404

Query: 357 HEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRI 410
               P  F+DE G  K +++  PF +G+R C G++LA   +F+    ILQ + +
Sbjct: 405 EMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 458



 Score = 65.3 bits (152), Expect = 4e-10
 Identities = 49/166 (29%), Positives = 79/166 (47%), Gaps = 10/166 (6%)

Query: 33  MAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKN 92
           + PGP   P  G+   + Q+  K  S  K+L  LSK +   V  L  G + +VV++G + 
Sbjct: 29  LPPGPTPLPVIGN---ILQIGIKDIS--KSLTNLSKVYGP-VFTLYFGLKPIVVLHGYEA 82

Query: 93  VRQVFSE--SEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTS 150
           V++   +   EF GR    F       +  G+ F +G  W+E R+F++  L+N G GK S
Sbjct: 83  VKEALIDLGEEFSGR--GIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRS 140

Query: 151 MELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGER 196
           +E  +Q E + L E +   K  P     +   A  NV+   +  +R
Sbjct: 141 IEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKR 186


>AY341248-1|AAP88931.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 9 protein.
          Length = 490

 Score =  123 bits (297), Expect = 1e-27
 Identities = 62/174 (35%), Positives = 97/174 (55%), Gaps = 1/174 (0%)

Query: 238 DQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSK 296
           + L+   +DL  AG++TT   +++ALL +L++  +  K+  EIE  IG +  PC  D S 
Sbjct: 285 ESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSH 344

Query: 297 LVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDP 356
           + YT A + EV R   + P + P  V  D     Y+IPK TT+LISL  +  D   +P+P
Sbjct: 345 MPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNP 404

Query: 357 HEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRI 410
               P  F+DE G  K +++  PF +G+R C G++LA   +F+    ILQ + +
Sbjct: 405 EMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 458



 Score = 65.3 bits (152), Expect = 4e-10
 Identities = 49/166 (29%), Positives = 79/166 (47%), Gaps = 10/166 (6%)

Query: 33  MAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKN 92
           + PGP   P  G+   + Q+  K  S  K+L  LSK +   V  L  G + +VV++G + 
Sbjct: 29  LPPGPTPLPVIGN---ILQIGIKDIS--KSLTNLSKVYGP-VFTLYFGLKPIVVLHGYEA 82

Query: 93  VRQVFSE--SEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTS 150
           V++   +   EF GR    F       +  G+ F +G  W+E R+F++  L+N G GK S
Sbjct: 83  VKEALIDLGEEFSGR--GIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRS 140

Query: 151 MELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGER 196
           +E  +Q E + L E +   K  P     +   A  NV+   +  +R
Sbjct: 141 IEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKR 186


>AL359672-1|CAH71303.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 9 protein.
          Length = 490

 Score =  123 bits (297), Expect = 1e-27
 Identities = 62/174 (35%), Positives = 97/174 (55%), Gaps = 1/174 (0%)

Query: 238 DQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSK 296
           + L+   +DL  AG++TT   +++ALL +L++  +  K+  EIE  IG +  PC  D S 
Sbjct: 285 ESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSH 344

Query: 297 LVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDP 356
           + YT A + EV R   + P + P  V  D     Y+IPK TT+LISL  +  D   +P+P
Sbjct: 345 MPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNP 404

Query: 357 HEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRI 410
               P  F+DE G  K +++  PF +G+R C G++LA   +F+    ILQ + +
Sbjct: 405 EMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 458



 Score = 65.3 bits (152), Expect = 4e-10
 Identities = 49/166 (29%), Positives = 79/166 (47%), Gaps = 10/166 (6%)

Query: 33  MAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKN 92
           + PGP   P  G+   + Q+  K  S  K+L  LSK +   V  L  G + +VV++G + 
Sbjct: 29  LPPGPTPLPVIGN---ILQIGIKDIS--KSLTNLSKVYGP-VFTLYFGLKPIVVLHGYEA 82

Query: 93  VRQVFSE--SEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTS 150
           V++   +   EF GR    F       +  G+ F +G  W+E R+F++  L+N G GK S
Sbjct: 83  VKEALIDLGEEFSGR--GIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRS 140

Query: 151 MELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGER 196
           +E  +Q E + L E +   K  P     +   A  NV+   +  +R
Sbjct: 141 IEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKR 186


>M21941-1|AAA52160.1|  480|Homo sapiens CYP2C protein.
          Length = 480

 Score =  123 bits (296), Expect = 1e-27
 Identities = 61/196 (31%), Positives = 105/196 (53%), Gaps = 3/196 (1%)

Query: 246 DLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSKLVYTSAFL 304
           DL +AG++TT   +++ LL +L++  +  K+  EI++ IG    PC  D S + YT A +
Sbjct: 283 DLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVV 342

Query: 305 LEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERF 364
            E+ R   + P   P  V  DT    Y+IPK TT++  L  +  D   +P+P+   P  F
Sbjct: 343 HEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGLF 402

Query: 365 IDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGVLPSNEADI 424
           +D+ G  K +++  PF +G+R C G+ LAR  +F+    ILQ + +  V+ +   N   +
Sbjct: 403 LDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAV 462

Query: 425 --GLLAAPKPFVANFV 438
             G+++ P  +   F+
Sbjct: 463 TKGIVSLPPSYQICFI 478



 Score = 60.5 bits (140), Expect = 1e-08
 Identities = 51/181 (28%), Positives = 84/181 (46%), Gaps = 12/181 (6%)

Query: 33  MAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKN 92
           + PGP   P  G+   + Q+  K     K+    SK +   V  +  G   +VV +G + 
Sbjct: 19  LPPGPTPLPIIGN---MLQIDVK--DICKSFTNFSKVYGP-VFTVYFGMNPIVVFHGYEA 72

Query: 93  VRQVFSES--EFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTS 150
           V++   ++  EF GR NS   +   + K LG+   +G  W+E R+F++  L+N G GK S
Sbjct: 73  VKEALIDNGEEFSGRGNSPISQR--ITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRS 130

Query: 151 MELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERI--REDKLERLLEL 208
           +E  +Q E   L E +   K  P     +   A  NV+   V  +R   ++ K   L++ 
Sbjct: 131 IEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQKFLTLMKR 190

Query: 209 F 209
           F
Sbjct: 191 F 191


>BC025761-1|AAH25761.2|  490|Homo sapiens cytochrome P450, family 2,
           subfamily W, polypeptide 1 protein.
          Length = 490

 Score =  123 bits (296), Expect = 1e-27
 Identities = 64/177 (36%), Positives = 101/177 (57%), Gaps = 2/177 (1%)

Query: 245 LDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSM-PCWADSSKLVYTSAF 303
           LD+++AG++TT   +++A L + R+ ++Q ++  E++  +G    P   D   L YTSA 
Sbjct: 291 LDMVMAGTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAV 350

Query: 304 LLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPER 363
           L EV R  T+ P   PR    DT + G+++PK T V+  L  + LD   W  P +  P  
Sbjct: 351 LHEVQRFITLLPHV-PRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGH 409

Query: 364 FIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGVLPSN 420
           F+D  G     E   PF +GRR C G+ LAR+ +F++F G+LQ+YR+    GV P++
Sbjct: 410 FLDANGHFVKREAFLPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSPAS 466



 Score = 60.1 bits (139), Expect = 2e-08
 Identities = 49/175 (28%), Positives = 86/175 (49%), Gaps = 13/175 (7%)

Query: 24  DPDFLNQWFMAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGREL 83
           DP    +W   PGP   P  G+  +++        Q ++L+ELS+++   V  + LGR+ 
Sbjct: 24  DPSPAARW--PPGPRPLPLVGNLHLLRL-----SQQDRSLMELSERYGP-VFTVHLGRQK 75

Query: 84  VVVVYGEKNVRQVFSE--SEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHL 141
            VV+ G + V++  +    E   RP    ++L   G   G+ F  G  WR  RQFTV+ L
Sbjct: 76  TVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGG--GIFFSSGARWRAARQFTVRAL 133

Query: 142 KNVGFGKTSMELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGER 196
            ++G G+  +  +I  ELK L   ++  + +P  + ++   A  N+ +  + G R
Sbjct: 134 HSLGVGREPVADKILQELKCLSGQLDGYRGRPFPL-ALLGWAPSNITFALLFGRR 187


>M21939-1|AAA52158.1|  485|Homo sapiens CYP2C protein.
          Length = 485

 Score =  120 bits (290), Expect = 8e-27
 Identities = 61/174 (35%), Positives = 96/174 (55%), Gaps = 1/174 (0%)

Query: 238 DQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSK 296
           + L+   +DL  AG++TT   +++ALL +L++  +  K+  EIE  IG +  PC  D S 
Sbjct: 280 ESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSH 339

Query: 297 LVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDP 356
           + YT A + EV R   + P + P  V  D     Y+IPK TT+LISL  +  D   +P+P
Sbjct: 340 MPYTDAVVHEVQRCIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNP 399

Query: 357 HEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRI 410
               P  F+DE    K +++  PF +G+R C G++LA   +F+    ILQ + +
Sbjct: 400 EMFDPHHFLDEGDNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 453



 Score = 65.3 bits (152), Expect = 4e-10
 Identities = 49/166 (29%), Positives = 79/166 (47%), Gaps = 10/166 (6%)

Query: 33  MAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKN 92
           + PGP   P  G+   + Q+  K  S  K+L  LSK +   V  L  G + +VV++G + 
Sbjct: 24  LPPGPTPLPVIGN---ILQIGIKDIS--KSLTNLSKVYGP-VFTLYFGLKPIVVLHGYEA 77

Query: 93  VRQVFSE--SEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTS 150
           V++   +   EF GR    F       +  G+ F +G  W+E R+F++  L+N G GK S
Sbjct: 78  VKEALIDLGEEFSGR--GIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRS 135

Query: 151 MELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGER 196
           +E  +Q E + L E +   K  P     +   A  NV+   +  +R
Sbjct: 136 IEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKR 181


>M15331-1|AAA52157.1|  485|Homo sapiens CYP2C protein.
          Length = 485

 Score =  120 bits (290), Expect = 8e-27
 Identities = 61/174 (35%), Positives = 96/174 (55%), Gaps = 1/174 (0%)

Query: 238 DQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSK 296
           + L+   +DL  AG++TT   +++ALL +L++  +  K+  EIE  IG +  PC  D S 
Sbjct: 280 ESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSH 339

Query: 297 LVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDP 356
           + YT A + EV R   + P + P  V  D     Y+IPK TT+LISL  +  D   +P+P
Sbjct: 340 MPYTDAVVHEVQRCIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNP 399

Query: 357 HEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRI 410
               P  F+DE    K +++  PF +G+R C G++LA   +F+    ILQ + +
Sbjct: 400 EMFDPHHFLDEGDNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 453



 Score = 65.3 bits (152), Expect = 4e-10
 Identities = 49/166 (29%), Positives = 79/166 (47%), Gaps = 10/166 (6%)

Query: 33  MAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKN 92
           + PGP   P  G+   + Q+  K  S  K+L  LSK +   V  L  G + +VV++G + 
Sbjct: 24  LPPGPTPLPVIGN---ILQIGIKDIS--KSLTNLSKVYGP-VFTLYFGLKPIVVLHGYEA 77

Query: 93  VRQVFSE--SEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTS 150
           V++   +   EF GR    F       +  G+ F +G  W+E R+F++  L+N G GK S
Sbjct: 78  VKEALIDLGEEFSGR--GIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRS 135

Query: 151 MELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGER 196
           +E  +Q E + L E +   K  P     +   A  NV+   +  +R
Sbjct: 136 IEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKR 181


>M33317-1|AAA52138.1|  494|Homo sapiens CYP2A protein.
          Length = 494

 Score =  120 bits (289), Expect = 1e-26
 Identities = 56/199 (28%), Positives = 107/199 (53%), Gaps = 3/199 (1%)

Query: 245 LDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDS-MPCWADSSKLVYTSAF 303
           L+L IAG++T    +++  L ++++  ++ K+  EI+  IG +  P + D +K+ Y  A 
Sbjct: 296 LNLFIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAV 355

Query: 304 LLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPER 363
           + E+ R   + P++  RRV +DT    + +PK T V   L  +  DP+ + +P +  P+ 
Sbjct: 356 IHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQH 415

Query: 364 FIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGV--LPSNE 421
           F+D+KG  K ++   PF  G+R C G+ LAR  +F+ F  ++Q +R+        +  + 
Sbjct: 416 FLDDKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSS 475

Query: 422 ADIGLLAAPKPFVANFVSR 440
             +G    P+ +  +F+ R
Sbjct: 476 KHVGFATIPRNYTMSFLPR 494



 Score = 55.6 bits (128), Expect = 3e-07
 Identities = 61/215 (28%), Positives = 92/215 (42%), Gaps = 19/215 (8%)

Query: 33  MAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKN 92
           + PGP   PF G+     Q+ ++H     ++++ S+ +   V  + LG   VVV+ G   
Sbjct: 33  LPPGPTPLPFIGN---YLQLNTEHICD--SIMKFSECYGP-VFTIHLGPRRVVVLCGHDA 86

Query: 93  VRQVFSES--EFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTS 150
           VR+   +   EF GR     +    + K  GV F +G   ++  +F +  L++ G GK  
Sbjct: 87  VREALVDQAEEFSGRGEQATFDW--VFKGYGVAFSNGERAKQLLRFAIATLRDFGVGKRG 144

Query: 151 MELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERI-REDK-----LER 204
           +E  IQ E   L E I  +    I      S  V NV+   V G+R   EDK     L  
Sbjct: 145 IEERIQEESGFLIEAIRSSHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLSM 204

Query: 205 LLELFYLRSKAFTLTGGLLSKIPWCRFIIPGLNDQ 239
           +L +F   S   T TG L          +PG   Q
Sbjct: 205 MLGIFQFTS---TSTGQLYEMFSSVMKHLPGPQQQ 236


>DQ211353-1|ABB01370.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score =  120 bits (289), Expect = 1e-26
 Identities = 63/199 (31%), Positives = 101/199 (50%), Gaps = 2/199 (1%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGD-SMPCWADSS 295
           ++ L+ V  DL  AG  TT   + + LL ++ + ++Q ++  EI++ IG    P   D +
Sbjct: 292 DENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQA 351

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
            + YT+A + EV R   I PL       +D  + G+ IPK TT++ +L+ +  D  +W  
Sbjct: 352 HMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEK 411

Query: 356 PHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNG 415
           P    PE F+D +G     E   PF +GRR C G+ LAR  +F+ F  +LQ +      G
Sbjct: 412 PFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVAAG 471

Query: 416 -VLPSNEADIGLLAAPKPF 433
              PS+   +  L  P P+
Sbjct: 472 QPRPSHSRVVSFLVTPSPY 490



 Score = 60.5 bits (140), Expect = 1e-08
 Identities = 46/157 (29%), Positives = 68/157 (43%), Gaps = 5/157 (3%)

Query: 74  VLGLKLGRELVVVVYGEKNVRQVFSESEFD--GRPNSFFYKLRCLGKRLGVTFVD--GPL 129
           V  L+L    VVV+ G   VR+       D   RP     ++   G R    F+   GP 
Sbjct: 68  VFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPA 127

Query: 130 WREHRQFTVKHLKNVGFGKTSMELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLW 189
           WRE R+F+V  L+N+G GK S+E  +  E   L     ++  +P + + +   AV NV+ 
Sbjct: 128 WREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIA 187

Query: 190 KYVAGERIREDKLERLLELFYLRSKAFTLTGGLLSKI 226
               G R   D   R L L  L  +      G L ++
Sbjct: 188 SLTCGRRFEYDD-PRFLRLLDLAQEGLKEESGFLREV 223


>X08006-1|CAA30807.1|  497|Homo sapiens cytochrome P450 db1 protein.
          Length = 497

 Score =  120 bits (288), Expect = 1e-26
 Identities = 63/199 (31%), Positives = 101/199 (50%), Gaps = 2/199 (1%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGD-SMPCWADSS 295
           ++ L+ V  DL  AG  TT   + + LL ++ + ++Q ++  EI++ IG    P   D +
Sbjct: 292 DENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQA 351

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
            + YT+A + EV R   I PL       +D  + G+ IPK TT++ +L+ +  D  +W  
Sbjct: 352 HMPYTTAVIHEVQRFGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEK 411

Query: 356 PHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNG 415
           P    PE F+D +G     E   PF +GRR C G+ LAR  +F+ F  +LQ +      G
Sbjct: 412 PFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG 471

Query: 416 -VLPSNEADIGLLAAPKPF 433
              PS+      L +P P+
Sbjct: 472 QPRPSHHGVFAFLVSPSPY 490



 Score = 60.5 bits (140), Expect = 1e-08
 Identities = 46/157 (29%), Positives = 68/157 (43%), Gaps = 5/157 (3%)

Query: 74  VLGLKLGRELVVVVYGEKNVRQVFSESEFD--GRPNSFFYKLRCLGKRLGVTFVD--GPL 129
           V  L+L    VVV+ G   VR+       D   RP     ++   G R    F+   GP 
Sbjct: 68  VFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPA 127

Query: 130 WREHRQFTVKHLKNVGFGKTSMELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLW 189
           WRE R+F+V  L+N+G GK S+E  +  E   L     ++  +P + + +   AV NV+ 
Sbjct: 128 WREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIA 187

Query: 190 KYVAGERIREDKLERLLELFYLRSKAFTLTGGLLSKI 226
               G R   D   R L L  L  +      G L ++
Sbjct: 188 SLTCGRRFEYDD-PRFLRLLDLAQEGLKEESGFLREV 223


>M33388-1|AAA53500.1|  497|Homo sapiens cytochrome P450 IID6
           protein.
          Length = 497

 Score =  120 bits (288), Expect = 1e-26
 Identities = 63/199 (31%), Positives = 101/199 (50%), Gaps = 2/199 (1%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGD-SMPCWADSS 295
           ++ L+ V  DL  AG  TT   + + LL ++ + ++Q ++  EI++ IG    P   D +
Sbjct: 292 DENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQA 351

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
            + YT+A + EV R   I PL       +D  + G+ IPK TT++ +L+ +  D  +W  
Sbjct: 352 HMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEK 411

Query: 356 PHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNG 415
           P    PE F+D +G     E   PF +GRR C G+ LAR  +F+ F  +LQ +      G
Sbjct: 412 PFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG 471

Query: 416 -VLPSNEADIGLLAAPKPF 433
              PS+      L +P P+
Sbjct: 472 QPRPSHHGVFAFLVSPSPY 490



 Score = 60.5 bits (140), Expect = 1e-08
 Identities = 46/157 (29%), Positives = 68/157 (43%), Gaps = 5/157 (3%)

Query: 74  VLGLKLGRELVVVVYGEKNVRQVFSESEFD--GRPNSFFYKLRCLGKRLGVTFVD--GPL 129
           V  L+L    VVV+ G   VR+       D   RP     ++   G R    F+   GP 
Sbjct: 68  VFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPA 127

Query: 130 WREHRQFTVKHLKNVGFGKTSMELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLW 189
           WRE R+F+V  L+N+G GK S+E  +  E   L     ++  +P + + +   AV NV+ 
Sbjct: 128 WREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIA 187

Query: 190 KYVAGERIREDKLERLLELFYLRSKAFTLTGGLLSKI 226
               G R   D   R L L  L  +      G L ++
Sbjct: 188 SLTCGRRFEYDD-PRFLRLLDLAQEGLKEESGFLREV 223


>M20403-1|AAA52153.1|  497|Homo sapiens CYP2D protein.
          Length = 497

 Score =  120 bits (288), Expect = 1e-26
 Identities = 63/199 (31%), Positives = 101/199 (50%), Gaps = 2/199 (1%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGD-SMPCWADSS 295
           ++ L+ V  DL  AG  TT   + + LL ++ + ++Q ++  EI++ IG    P   D +
Sbjct: 292 DENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQA 351

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
            + YT+A + EV R   I PL       +D  + G+ IPK TT++ +L+ +  D  +W  
Sbjct: 352 HMPYTTAVIHEVQRFGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEK 411

Query: 356 PHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNG 415
           P    PE F+D +G     E   PF +GRR C G+ LAR  +F+ F  +LQ +      G
Sbjct: 412 PFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG 471

Query: 416 -VLPSNEADIGLLAAPKPF 433
              PS+      L +P P+
Sbjct: 472 QPRPSHHGVFAFLVSPSPY 490



 Score = 60.5 bits (140), Expect = 1e-08
 Identities = 46/157 (29%), Positives = 68/157 (43%), Gaps = 5/157 (3%)

Query: 74  VLGLKLGRELVVVVYGEKNVRQVFSESEFD--GRPNSFFYKLRCLGKRLGVTFVD--GPL 129
           V  L+L    VVV+ G   VR+       D   RP     ++   G R    F+   GP 
Sbjct: 68  VFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPA 127

Query: 130 WREHRQFTVKHLKNVGFGKTSMELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLW 189
           WRE R+F+V  L+N+G GK S+E  +  E   L     ++  +P + + +   AV NV+ 
Sbjct: 128 WREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIA 187

Query: 190 KYVAGERIREDKLERLLELFYLRSKAFTLTGGLLSKI 226
               G R   D   R L L  L  +      G L ++
Sbjct: 188 SLTCGRRFEYDD-PRFLRLLDLAQEGLKEESGFLREV 223


>DQ282154-1|ABB77902.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score =  120 bits (288), Expect = 1e-26
 Identities = 63/199 (31%), Positives = 101/199 (50%), Gaps = 2/199 (1%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGD-SMPCWADSS 295
           ++ L+ V  DL  AG  TT   + + LL ++ + ++Q ++  EI++ IG    P   D +
Sbjct: 292 DENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQA 351

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
            + YT+A + EV R   I PL       +D  + G+ IPK TT++ +L+ +  D  +W  
Sbjct: 352 HMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEK 411

Query: 356 PHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNG 415
           P    PE F+D +G     E   PF +GRR C G+ LAR  +F+ F  +LQ +      G
Sbjct: 412 PFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG 471

Query: 416 -VLPSNEADIGLLAAPKPF 433
              PS+      L +P P+
Sbjct: 472 QPRPSHHGVFAFLVSPSPY 490



 Score = 60.5 bits (140), Expect = 1e-08
 Identities = 46/157 (29%), Positives = 68/157 (43%), Gaps = 5/157 (3%)

Query: 74  VLGLKLGRELVVVVYGEKNVRQVFSESEFD--GRPNSFFYKLRCLGKRLGVTFVD--GPL 129
           V  L+L    VVV+ G   VR+       D   RP     ++   G R    F+   GP 
Sbjct: 68  VFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPA 127

Query: 130 WREHRQFTVKHLKNVGFGKTSMELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLW 189
           WRE R+F+V  L+N+G GK S+E  +  E   L     ++  +P + + +   AV NV+ 
Sbjct: 128 WREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIA 187

Query: 190 KYVAGERIREDKLERLLELFYLRSKAFTLTGGLLSKI 226
               G R   D   R L L  L  +      G L ++
Sbjct: 188 SLTCGRRFEYDD-PRFLRLLDLAQEGLKEESGFLREV 223


>DQ282151-1|ABB77899.1|  496|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 496

 Score =  120 bits (288), Expect = 1e-26
 Identities = 63/199 (31%), Positives = 101/199 (50%), Gaps = 2/199 (1%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGD-SMPCWADSS 295
           ++ L+ V  DL  AG  TT   + + LL ++ + ++Q ++  EI++ IG    P   D +
Sbjct: 291 DENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQA 350

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
            + YT+A + EV R   I PL       +D  + G+ IPK TT++ +L+ +  D  +W  
Sbjct: 351 HMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEK 410

Query: 356 PHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNG 415
           P    PE F+D +G     E   PF +GRR C G+ LAR  +F+ F  +LQ +      G
Sbjct: 411 PFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG 470

Query: 416 -VLPSNEADIGLLAAPKPF 433
              PS+      L +P P+
Sbjct: 471 QPRPSHHGVFAFLVSPSPY 489



 Score = 60.5 bits (140), Expect = 1e-08
 Identities = 46/157 (29%), Positives = 68/157 (43%), Gaps = 5/157 (3%)

Query: 74  VLGLKLGRELVVVVYGEKNVRQVFSESEFD--GRPNSFFYKLRCLGKRLGVTFVD--GPL 129
           V  L+L    VVV+ G   VR+       D   RP     ++   G R    F+   GP 
Sbjct: 68  VFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPA 127

Query: 130 WREHRQFTVKHLKNVGFGKTSMELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLW 189
           WRE R+F+V  L+N+G GK S+E  +  E   L     ++  +P + + +   AV NV+ 
Sbjct: 128 WREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIA 187

Query: 190 KYVAGERIREDKLERLLELFYLRSKAFTLTGGLLSKI 226
               G R   D   R L L  L  +      G L ++
Sbjct: 188 SLTCGRRFEYDD-PRFLRLLDLAQEGLKEESGFLREV 223


>DQ282146-1|ABB77897.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score =  120 bits (288), Expect = 1e-26
 Identities = 63/199 (31%), Positives = 101/199 (50%), Gaps = 2/199 (1%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGD-SMPCWADSS 295
           ++ L+ V  DL  AG  TT   + + LL ++ + ++Q ++  EI++ IG    P   D +
Sbjct: 292 DENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQA 351

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
            + YT+A + EV R   I PL       +D  + G+ IPK TT++ +L+ +  D  +W  
Sbjct: 352 HMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEK 411

Query: 356 PHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNG 415
           P    PE F+D +G     E   PF +GRR C G+ LAR  +F+ F  +LQ +      G
Sbjct: 412 PFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG 471

Query: 416 -VLPSNEADIGLLAAPKPF 433
              PS+      L +P P+
Sbjct: 472 QPRPSHHGVFAFLVSPSPY 490



 Score = 60.5 bits (140), Expect = 1e-08
 Identities = 46/157 (29%), Positives = 68/157 (43%), Gaps = 5/157 (3%)

Query: 74  VLGLKLGRELVVVVYGEKNVRQVFSESEFD--GRPNSFFYKLRCLGKRLGVTFVD--GPL 129
           V  L+L    VVV+ G   VR+       D   RP     ++   G R    F+   GP 
Sbjct: 68  VFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPA 127

Query: 130 WREHRQFTVKHLKNVGFGKTSMELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLW 189
           WRE R+F+V  L+N+G GK S+E  +  E   L     ++  +P + + +   AV NV+ 
Sbjct: 128 WREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIA 187

Query: 190 KYVAGERIREDKLERLLELFYLRSKAFTLTGGLLSKI 226
               G R   D   R L L  L  +      G L ++
Sbjct: 188 SLTCGRRFEYDD-PRFLRLLDLAQEGLKEESGFLREV 223


>DQ282145-1|ABB77896.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score =  120 bits (288), Expect = 1e-26
 Identities = 63/199 (31%), Positives = 101/199 (50%), Gaps = 2/199 (1%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGD-SMPCWADSS 295
           ++ L+ V  DL  AG  TT   + + LL ++ + ++Q ++  EI++ IG    P   D +
Sbjct: 292 DENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQA 351

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
            + YT+A + EV R   I PL       +D  + G+ IPK TT++ +L+ +  D  +W  
Sbjct: 352 HMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEK 411

Query: 356 PHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNG 415
           P    PE F+D +G     E   PF +GRR C G+ LAR  +F+ F  +LQ +      G
Sbjct: 412 PFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG 471

Query: 416 -VLPSNEADIGLLAAPKPF 433
              PS+      L +P P+
Sbjct: 472 QPRPSHHGVFAFLVSPSPY 490



 Score = 60.5 bits (140), Expect = 1e-08
 Identities = 46/157 (29%), Positives = 68/157 (43%), Gaps = 5/157 (3%)

Query: 74  VLGLKLGRELVVVVYGEKNVRQVFSESEFD--GRPNSFFYKLRCLGKRLGVTFVD--GPL 129
           V  L+L    VVV+ G   VR+       D   RP     ++   G R    F+   GP 
Sbjct: 68  VFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPA 127

Query: 130 WREHRQFTVKHLKNVGFGKTSMELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLW 189
           WRE R+F+V  L+N+G GK S+E  +  E   L     ++  +P + + +   AV NV+ 
Sbjct: 128 WREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIA 187

Query: 190 KYVAGERIREDKLERLLELFYLRSKAFTLTGGLLSKI 226
               G R   D   R L L  L  +      G L ++
Sbjct: 188 SLTCGRRFEYDD-PRFLRLLDLAQEGLKEESGFLREV 223


>DQ282144-1|ABB77895.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score =  120 bits (288), Expect = 1e-26
 Identities = 63/199 (31%), Positives = 101/199 (50%), Gaps = 2/199 (1%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGD-SMPCWADSS 295
           ++ L+ V  DL  AG  TT   + + LL ++ + ++Q ++  EI++ IG    P   D +
Sbjct: 292 DENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQA 351

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
            + YT+A + EV R   I PL       +D  + G+ IPK TT++ +L+ +  D  +W  
Sbjct: 352 HMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEK 411

Query: 356 PHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNG 415
           P    PE F+D +G     E   PF +GRR C G+ LAR  +F+ F  +LQ +      G
Sbjct: 412 PFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG 471

Query: 416 -VLPSNEADIGLLAAPKPF 433
              PS+      L +P P+
Sbjct: 472 QPRPSHHGVFAFLVSPSPY 490



 Score = 60.5 bits (140), Expect = 1e-08
 Identities = 46/157 (29%), Positives = 68/157 (43%), Gaps = 5/157 (3%)

Query: 74  VLGLKLGRELVVVVYGEKNVRQVFSESEFD--GRPNSFFYKLRCLGKRLGVTFVD--GPL 129
           V  L+L    VVV+ G   VR+       D   RP     ++   G R    F+   GP 
Sbjct: 68  VFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPA 127

Query: 130 WREHRQFTVKHLKNVGFGKTSMELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLW 189
           WRE R+F+V  L+N+G GK S+E  +  E   L     ++  +P + + +   AV NV+ 
Sbjct: 128 WREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIA 187

Query: 190 KYVAGERIREDKLERLLELFYLRSKAFTLTGGLLSKI 226
               G R   D   R L L  L  +      G L ++
Sbjct: 188 SLTCGRRFEYDD-PRFLRLLDLAQEGLKEESGFLREV 223


>BC117165-1|AAI17166.1|  494|Homo sapiens cytochrome P450, family 2,
           subfamily A, polypeptide 7 protein.
          Length = 494

 Score =  120 bits (288), Expect = 1e-26
 Identities = 56/199 (28%), Positives = 107/199 (53%), Gaps = 3/199 (1%)

Query: 245 LDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDS-MPCWADSSKLVYTSAF 303
           L+L IAG++T    +++  L ++++  ++ K+  EI+  IG +  P + D +K+ Y  A 
Sbjct: 296 LNLFIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAV 355

Query: 304 LLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPER 363
           + E+ R   + P++  RRV +DT    + +PK T V   L  +  DP+ + +P +  P+ 
Sbjct: 356 IHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQH 415

Query: 364 FIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGV--LPSNE 421
           F+D+KG  K ++   PF  G+R C G+ LAR  +F+ F  ++Q +R+        +  + 
Sbjct: 416 FLDDKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSP 475

Query: 422 ADIGLLAAPKPFVANFVSR 440
             +G    P+ +  +F+ R
Sbjct: 476 KHVGFATIPRNYTMSFLPR 494



 Score = 53.2 bits (122), Expect = 2e-06
 Identities = 58/212 (27%), Positives = 88/212 (41%), Gaps = 13/212 (6%)

Query: 33  MAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKN 92
           + PGP   PF G+     Q+ ++H     ++++ S+ +   V  + LG    VV+ G   
Sbjct: 33  LPPGPTPLPFIGN---YLQLNTEHICD--SIMKFSECYGP-VFTIHLGPRRAVVLCGHDA 86

Query: 93  VRQVFSES--EFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTS 150
           VR+   +   EF GR     +    + K  GV F +G   ++  +F +  L++ G GK  
Sbjct: 87  VREALVDQAEEFSGRGEQATFDW--VFKGYGVAFSNGERAKQLLRFAIATLRDFGVGKRG 144

Query: 151 MELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERI-REDK--LERLLE 207
           +E  IQ E   L E I       I      S  V NV+   V G+R   EDK  L  L  
Sbjct: 145 IEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLSV 204

Query: 208 LFYLRSKAFTLTGGLLSKIPWCRFIIPGLNDQ 239
           +  +     T TG L          +PG   Q
Sbjct: 205 MLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQ 236


>BC075024-1|AAH75024.1|  497|Homo sapiens cytochrome P450, family 2,
           subfamily D, polypeptide 6 protein.
          Length = 497

 Score =  120 bits (288), Expect = 1e-26
 Identities = 63/199 (31%), Positives = 101/199 (50%), Gaps = 2/199 (1%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGD-SMPCWADSS 295
           ++ L+ V  DL  AG  TT   + + LL ++ + ++Q ++  EI++ IG    P   D +
Sbjct: 292 DENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQA 351

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
            + YT+A + EV R   I PL       +D  + G+ IPK TT++ +L+ +  D  +W  
Sbjct: 352 HMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEK 411

Query: 356 PHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNG 415
           P    PE F+D +G     E   PF +GRR C G+ LAR  +F+ F  +LQ +      G
Sbjct: 412 PFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG 471

Query: 416 -VLPSNEADIGLLAAPKPF 433
              PS+      L +P P+
Sbjct: 472 QPRPSHHGVFAFLVSPSPY 490



 Score = 60.5 bits (140), Expect = 1e-08
 Identities = 46/157 (29%), Positives = 68/157 (43%), Gaps = 5/157 (3%)

Query: 74  VLGLKLGRELVVVVYGEKNVRQVFSESEFD--GRPNSFFYKLRCLGKRLGVTFVD--GPL 129
           V  L+L    VVV+ G   VR+       D   RP     ++   G R    F+   GP 
Sbjct: 68  VFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPA 127

Query: 130 WREHRQFTVKHLKNVGFGKTSMELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLW 189
           WRE R+F+V  L+N+G GK S+E  +  E   L     ++  +P + + +   AV NV+ 
Sbjct: 128 WREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIA 187

Query: 190 KYVAGERIREDKLERLLELFYLRSKAFTLTGGLLSKI 226
               G R   D   R L L  L  +      G L ++
Sbjct: 188 SLTCGRRFEYDD-PRFLRLLDLAQEGLKEESGFLREV 223


>BC075023-1|AAH75023.1|  497|Homo sapiens cytochrome P450, family 2,
           subfamily D, polypeptide 6 protein.
          Length = 497

 Score =  120 bits (288), Expect = 1e-26
 Identities = 63/199 (31%), Positives = 101/199 (50%), Gaps = 2/199 (1%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGD-SMPCWADSS 295
           ++ L+ V  DL  AG  TT   + + LL ++ + ++Q ++  EI++ IG    P   D +
Sbjct: 292 DENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQA 351

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
            + YT+A + EV R   I PL       +D  + G+ IPK TT++ +L+ +  D  +W  
Sbjct: 352 HMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEK 411

Query: 356 PHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNG 415
           P    PE F+D +G     E   PF +GRR C G+ LAR  +F+ F  +LQ +      G
Sbjct: 412 PFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG 471

Query: 416 -VLPSNEADIGLLAAPKPF 433
              PS+      L +P P+
Sbjct: 472 QPRPSHHGVFAFLVSPSPY 490



 Score = 60.5 bits (140), Expect = 1e-08
 Identities = 46/157 (29%), Positives = 68/157 (43%), Gaps = 5/157 (3%)

Query: 74  VLGLKLGRELVVVVYGEKNVRQVFSESEFD--GRPNSFFYKLRCLGKRLGVTFVD--GPL 129
           V  L+L    VVV+ G   VR+       D   RP     ++   G R    F+   GP 
Sbjct: 68  VFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPA 127

Query: 130 WREHRQFTVKHLKNVGFGKTSMELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLW 189
           WRE R+F+V  L+N+G GK S+E  +  E   L     ++  +P + + +   AV NV+ 
Sbjct: 128 WREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIA 187

Query: 190 KYVAGERIREDKLERLLELFYLRSKAFTLTGGLLSKI 226
               G R   D   R L L  L  +      G L ++
Sbjct: 188 SLTCGRRFEYDD-PRFLRLLDLAQEGLKEESGFLREV 223


>AY545216-1|AAS55001.1|  497|Homo sapiens cytochrome P4502D6
           protein.
          Length = 497

 Score =  120 bits (288), Expect = 1e-26
 Identities = 63/199 (31%), Positives = 101/199 (50%), Gaps = 2/199 (1%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGD-SMPCWADSS 295
           ++ L+ V  DL  AG  TT   + + LL ++ + ++Q ++  EI++ IG    P   D +
Sbjct: 292 DENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQA 351

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
            + YT+A + EV R   I PL       +D  + G+ IPK TT++ +L+ +  D  +W  
Sbjct: 352 HMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEK 411

Query: 356 PHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNG 415
           P    PE F+D +G     E   PF +GRR C G+ LAR  +F+ F  +LQ +      G
Sbjct: 412 PFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG 471

Query: 416 -VLPSNEADIGLLAAPKPF 433
              PS+      L +P P+
Sbjct: 472 QPRPSHHGVFAFLVSPSPY 490



 Score = 60.5 bits (140), Expect = 1e-08
 Identities = 46/157 (29%), Positives = 68/157 (43%), Gaps = 5/157 (3%)

Query: 74  VLGLKLGRELVVVVYGEKNVRQVFSESEFD--GRPNSFFYKLRCLGKRLGVTFVD--GPL 129
           V  L+L    VVV+ G   VR+       D   RP     ++   G R    F+   GP 
Sbjct: 68  VFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPA 127

Query: 130 WREHRQFTVKHLKNVGFGKTSMELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLW 189
           WRE R+F+V  L+N+G GK S+E  +  E   L     ++  +P + + +   AV NV+ 
Sbjct: 128 WREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIA 187

Query: 190 KYVAGERIREDKLERLLELFYLRSKAFTLTGGLLSKI 226
               G R   D   R L L  L  +      G L ++
Sbjct: 188 SLTCGRRFEYDD-PRFLRLLDLAQEGLKEESGFLREV 223


>M61854-1|AAB59426.1|  490|Homo sapiens cytochrome protein.
          Length = 490

 Score =  119 bits (287), Expect = 2e-26
 Identities = 61/174 (35%), Positives = 93/174 (53%), Gaps = 1/174 (0%)

Query: 238 DQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSK 296
           + L     DL+ AG++TT   +++ALL +L++  +  K+  EIE  IG +  PC  D   
Sbjct: 285 ENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGH 344

Query: 297 LVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDP 356
           + YT A + EV R   + P + P  V  D     Y+IPK TT+L SL  +  D   +P+P
Sbjct: 345 MPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNP 404

Query: 357 HEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRI 410
               P  F+DE G  K + +  PF +G+R C G+ LAR  +F+    ILQ + +
Sbjct: 405 EMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNL 458



 Score = 66.1 bits (154), Expect = 2e-10
 Identities = 50/166 (30%), Positives = 80/166 (48%), Gaps = 10/166 (6%)

Query: 33  MAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKN 92
           + PGP   P  G+   + Q+  K  S  K+L  LSK +   V  L  G E +VV++G + 
Sbjct: 29  LPPGPTPLPVIGN---ILQIDIKDVS--KSLTNLSKIYGP-VFTLYFGLERMVVLHGYEV 82

Query: 93  VRQVFSE--SEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTS 150
           V++   +   EF GR +  F       +  G+ F +G  W+E R+F++  L+N G GK S
Sbjct: 83  VKEALIDLGEEFSGRGH--FPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRS 140

Query: 151 MELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGER 196
           +E  +Q E + L E +   K  P     +   A  NV+   +  +R
Sbjct: 141 IEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKR 186


>M33189-1|AAA35737.1|  500|Homo sapiens protein ( Human debrisoquine
           4-hydroxylase mutant allele (CYP2D6-MA1) gene, complete
           cds. ).
          Length = 500

 Score =  119 bits (287), Expect = 2e-26
 Identities = 63/199 (31%), Positives = 100/199 (50%), Gaps = 2/199 (1%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGD-SMPCWADSS 295
           ++ L+ V  DL  AG  TT   + + LL ++ + ++Q ++  EI++ IG    P   D +
Sbjct: 295 DENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQA 354

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
            + YT+A + EV R   I PL       +D  + G+ IPK TT++ +L+ +  D  +W  
Sbjct: 355 HMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEK 414

Query: 356 PHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNG 415
           P    PE F+D +G     E   PF +GRR C G+ LAR  +F+ F  +LQ +      G
Sbjct: 415 PFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG 474

Query: 416 -VLPSNEADIGLLAAPKPF 433
              PS+      L  P P+
Sbjct: 475 QPRPSHHGVFAFLVTPSPY 493


>M29874-1|AAA52144.1|  491|Homo sapiens CYP2B protein.
          Length = 491

 Score =  119 bits (287), Expect = 2e-26
 Identities = 57/165 (34%), Positives = 90/165 (54%), Gaps = 1/165 (0%)

Query: 245 LDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPCWA-DSSKLVYTSAF 303
           L L  AG++TT   +++  L +L+  ++ E+++ EIE  IG   P    D +K+ YT A 
Sbjct: 293 LSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAV 352

Query: 304 LLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPER 363
           + E+ R   + P+  P  V Q T   GY+IPK+T V + L+    DP+ +  P    P+ 
Sbjct: 353 IYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDH 412

Query: 364 FIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKY 408
           F+D  G  K  E   PF  G+R C G+ +AR+ +F+ F  ILQ +
Sbjct: 413 FLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNF 457



 Score = 58.8 bits (136), Expect = 4e-08
 Identities = 49/182 (26%), Positives = 85/182 (46%), Gaps = 12/182 (6%)

Query: 33  MAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKN 92
           + PGP   P  G+   + QM  +     K+ L   +++   V  + LG   VV++ G + 
Sbjct: 30  LPPGPRPLPLLGN---LLQMDRR--GLLKSFLRFREKYG-DVFTVHLGPRPVVMLCGVEA 83

Query: 93  VRQVFSESE--FDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTS 150
           +R+   +    F GR           G   GV F +G  W+  R+F+V  +++ G GK S
Sbjct: 84  IREALVDKAEAFSGRGKIAMVDPFFRG--YGVIFANGNRWKVLRRFSVTTMRDFGMGKRS 141

Query: 151 MELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERI--REDKLERLLEL 208
           +E  IQ E + L E +  +K   +    +F S   N++   V G+R   ++ +  ++L L
Sbjct: 142 VEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNL 201

Query: 209 FY 210
           FY
Sbjct: 202 FY 203


>M24499-1|AAA36403.1|  373|Homo sapiens cytochrome P450db1 protein.
          Length = 373

 Score =  119 bits (287), Expect = 2e-26
 Identities = 63/199 (31%), Positives = 100/199 (50%), Gaps = 2/199 (1%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGD-SMPCWADSS 295
           ++ L+ V  DL  AG  TT   + + LL ++ + ++Q ++  EI++ IG    P   D +
Sbjct: 168 DENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQA 227

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
            + YT+A + EV R   I PL       +D  + G+ IPK TT++ +L+ +  D  +W  
Sbjct: 228 HMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEK 287

Query: 356 PHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNG 415
           P    PE F+D +G     E   PF +GRR C G+ LAR  +F+ F  +LQ +      G
Sbjct: 288 PFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG 347

Query: 416 -VLPSNEADIGLLAAPKPF 433
              PS+      L  P P+
Sbjct: 348 QPRPSHHGVFAFLVTPSPY 366



 Score = 58.0 bits (134), Expect = 6e-08
 Identities = 31/100 (31%), Positives = 47/100 (47%), Gaps = 1/100 (1%)

Query: 127 GPLWREHRQFTVKHLKNVGFGKTSMELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMN 186
           GP WRE R+F+V  L+N+G GK S+E  +  E   L     ++  +P + + +   AV N
Sbjct: 1   GPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSN 60

Query: 187 VLWKYVAGERIREDKLERLLELFYLRSKAFTLTGGLLSKI 226
           V+     G R   D   R L L  L  +      G L ++
Sbjct: 61  VIASLTCGRRFEYDD-PRFLRLLDLAQEGLKEESGFLREV 99


>L39102-1|AAL31348.1|  217|Homo sapiens S-mephenytoin 4-hydroxylase
           protein.
          Length = 217

 Score =  119 bits (287), Expect = 2e-26
 Identities = 61/174 (35%), Positives = 93/174 (53%), Gaps = 1/174 (0%)

Query: 238 DQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSK 296
           + L     DL+ AG++TT   +++ALL +L++  +  K+  EIE  IG +  PC  D   
Sbjct: 12  ENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGH 71

Query: 297 LVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDP 356
           + YT A + EV R   + P + P  V  D     Y+IPK TT+L SL  +  D   +P+P
Sbjct: 72  MPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNP 131

Query: 357 HEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRI 410
               P  F+DE G  K + +  PF +G+R C G+ LAR  +F+    ILQ + +
Sbjct: 132 EMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNL 185


>DQ298753-1|ABB84469.1|  491|Homo sapiens cytochrome P450, family 2,
           subfamily B, polypeptide 6 protein.
          Length = 491

 Score =  119 bits (287), Expect = 2e-26
 Identities = 57/165 (34%), Positives = 90/165 (54%), Gaps = 1/165 (0%)

Query: 245 LDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPCWA-DSSKLVYTSAF 303
           L L  AG++TT   +++  L +L+  ++ E+++ EIE  IG   P    D +K+ YT A 
Sbjct: 293 LSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAV 352

Query: 304 LLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPER 363
           + E+ R   + P+  P  V Q T   GY+IPK+T V + L+    DP+ +  P    P+ 
Sbjct: 353 IYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDH 412

Query: 364 FIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKY 408
           F+D  G  K  E   PF  G+R C G+ +AR+ +F+ F  ILQ +
Sbjct: 413 FLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNF 457



 Score = 58.8 bits (136), Expect = 4e-08
 Identities = 49/182 (26%), Positives = 85/182 (46%), Gaps = 12/182 (6%)

Query: 33  MAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKN 92
           + PGP   P  G+   + QM  +     K+ L   +++   V  + LG   VV++ G + 
Sbjct: 30  LPPGPRPLPLLGN---LLQMDRR--GLLKSFLRFREKYG-DVFTVHLGPRPVVMLCGVEA 83

Query: 93  VRQVFSESE--FDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTS 150
           +R+   +    F GR           G   GV F +G  W+  R+F+V  +++ G GK S
Sbjct: 84  IREALVDKAEAFSGRGKIAMVDPFFRG--YGVIFANGNRWKVLRRFSVTTMRDFGMGKRS 141

Query: 151 MELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERI--REDKLERLLEL 208
           +E  IQ E + L E +  +K   +    +F S   N++   V G+R   ++ +  ++L L
Sbjct: 142 VEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNL 201

Query: 209 FY 210
           FY
Sbjct: 202 FY 203


>DQ282152-1|ABB77900.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score =  119 bits (287), Expect = 2e-26
 Identities = 63/199 (31%), Positives = 100/199 (50%), Gaps = 2/199 (1%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGD-SMPCWADSS 295
           ++ L+ V  DL  AG  TT   + + LL ++ + ++Q ++  EI++ IG    P   D +
Sbjct: 292 DENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQA 351

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
            + YT+A + EV R   I PL       +D  + G+ IPK TT++ +L+ +  D  +W  
Sbjct: 352 HMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEK 411

Query: 356 PHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNG 415
           P    PE F+D +G     E   PF +GRR C G+ LAR  +F+ F  +LQ +      G
Sbjct: 412 PFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG 471

Query: 416 -VLPSNEADIGLLAAPKPF 433
              PS+      L  P P+
Sbjct: 472 QPRPSHHGVFAFLVTPSPY 490



 Score = 60.5 bits (140), Expect = 1e-08
 Identities = 46/157 (29%), Positives = 68/157 (43%), Gaps = 5/157 (3%)

Query: 74  VLGLKLGRELVVVVYGEKNVRQVFSESEFD--GRPNSFFYKLRCLGKRLGVTFVD--GPL 129
           V  L+L    VVV+ G   VR+       D   RP     ++   G R    F+   GP 
Sbjct: 68  VFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPA 127

Query: 130 WREHRQFTVKHLKNVGFGKTSMELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLW 189
           WRE R+F+V  L+N+G GK S+E  +  E   L     ++  +P + + +   AV NV+ 
Sbjct: 128 WREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIA 187

Query: 190 KYVAGERIREDKLERLLELFYLRSKAFTLTGGLLSKI 226
               G R   D   R L L  L  +      G L ++
Sbjct: 188 SLTCGRRFEYDD-PRFLRLLDLAQEGLKEESGFLREV 223


>DQ211354-2|ABB01372.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score =  119 bits (287), Expect = 2e-26
 Identities = 63/199 (31%), Positives = 100/199 (50%), Gaps = 2/199 (1%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGD-SMPCWADSS 295
           ++ L+ V  DL  AG  TT   + + LL ++ + ++Q ++  EI++ IG    P   D +
Sbjct: 292 DENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQA 351

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
            + YT+A + EV R   I PL       +D  + G+ IPK TT++ +L+ +  D  +W  
Sbjct: 352 HMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEK 411

Query: 356 PHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNG 415
           P    PE F+D +G     E   PF +GRR C G+ LAR  +F+ F  +LQ +      G
Sbjct: 412 PFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG 471

Query: 416 -VLPSNEADIGLLAAPKPF 433
              PS+      L  P P+
Sbjct: 472 QPRPSHHGVFAFLVTPSPY 490



 Score = 60.5 bits (140), Expect = 1e-08
 Identities = 46/157 (29%), Positives = 68/157 (43%), Gaps = 5/157 (3%)

Query: 74  VLGLKLGRELVVVVYGEKNVRQVFSESEFD--GRPNSFFYKLRCLGKRLGVTFVD--GPL 129
           V  L+L    VVV+ G   VR+       D   RP     ++   G R    F+   GP 
Sbjct: 68  VFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPA 127

Query: 130 WREHRQFTVKHLKNVGFGKTSMELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLW 189
           WRE R+F+V  L+N+G GK S+E  +  E   L     ++  +P + + +   AV NV+ 
Sbjct: 128 WREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIA 187

Query: 190 KYVAGERIREDKLERLLELFYLRSKAFTLTGGLLSKI 226
               G R   D   R L L  L  +      G L ++
Sbjct: 188 SLTCGRRFEYDD-PRFLRLLDLAQEGLKEESGFLREV 223


>DQ211353-2|ABB01371.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score =  119 bits (287), Expect = 2e-26
 Identities = 63/199 (31%), Positives = 100/199 (50%), Gaps = 2/199 (1%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGD-SMPCWADSS 295
           ++ L+ V  DL  AG  TT   + + LL ++ + ++Q ++  EI++ IG    P   D +
Sbjct: 292 DENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQA 351

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
            + YT+A + EV R   I PL       +D  + G+ IPK TT++ +L+ +  D  +W  
Sbjct: 352 HMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEK 411

Query: 356 PHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNG 415
           P    PE F+D +G     E   PF +GRR C G+ LAR  +F+ F  +LQ +      G
Sbjct: 412 PFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG 471

Query: 416 -VLPSNEADIGLLAAPKPF 433
              PS+      L  P P+
Sbjct: 472 QPRPSHHGVFAFLVTPSPY 490



 Score = 60.5 bits (140), Expect = 1e-08
 Identities = 46/157 (29%), Positives = 68/157 (43%), Gaps = 5/157 (3%)

Query: 74  VLGLKLGRELVVVVYGEKNVRQVFSESEFD--GRPNSFFYKLRCLGKRLGVTFVD--GPL 129
           V  L+L    VVV+ G   VR+       D   RP     ++   G R    F+   GP 
Sbjct: 68  VFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPA 127

Query: 130 WREHRQFTVKHLKNVGFGKTSMELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLW 189
           WRE R+F+V  L+N+G GK S+E  +  E   L     ++  +P + + +   AV NV+ 
Sbjct: 128 WREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIA 187

Query: 190 KYVAGERIREDKLERLLELFYLRSKAFTLTGGLLSKI 226
               G R   D   R L L  L  +      G L ++
Sbjct: 188 SLTCGRRFEYDD-PRFLRLLDLAQEGLKEESGFLREV 223


>BC067431-1|AAH67431.1|  491|Homo sapiens cytochrome P450, family 2,
           subfamily B, polypeptide 6 protein.
          Length = 491

 Score =  119 bits (287), Expect = 2e-26
 Identities = 57/165 (34%), Positives = 90/165 (54%), Gaps = 1/165 (0%)

Query: 245 LDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPCWA-DSSKLVYTSAF 303
           L L  AG++TT   +++  L +L+  ++ E+++ EIE  IG   P    D +K+ YT A 
Sbjct: 293 LSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAV 352

Query: 304 LLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPER 363
           + E+ R   + P+  P  V Q T   GY+IPK+T V + L+    DP+ +  P    P+ 
Sbjct: 353 IYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDH 412

Query: 364 FIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKY 408
           F+D  G  K  E   PF  G+R C G+ +AR+ +F+ F  ILQ +
Sbjct: 413 FLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNF 457



 Score = 58.8 bits (136), Expect = 4e-08
 Identities = 49/182 (26%), Positives = 85/182 (46%), Gaps = 12/182 (6%)

Query: 33  MAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKN 92
           + PGP   P  G+   + QM  +     K+ L   +++   V  + LG   VV++ G + 
Sbjct: 30  LPPGPRPLPLLGN---LLQMDRR--GLLKSFLRFREKYG-DVFTVHLGPRPVVMLCGVEA 83

Query: 93  VRQVFSESE--FDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTS 150
           +R+   +    F GR           G   GV F +G  W+  R+F+V  +++ G GK S
Sbjct: 84  IREALVDKAEAFSGRGKIAMVDPFFRG--YGVIFANGNRWKVLRRFSVTTMRDFGMGKRS 141

Query: 151 MELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERI--REDKLERLLEL 208
           +E  IQ E + L E +  +K   +    +F S   N++   V G+R   ++ +  ++L L
Sbjct: 142 VEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNL 201

Query: 209 FY 210
           FY
Sbjct: 202 FY 203


>BC067430-1|AAH67430.1|  491|Homo sapiens cytochrome P450, family 2,
           subfamily B, polypeptide 6 protein.
          Length = 491

 Score =  119 bits (287), Expect = 2e-26
 Identities = 57/165 (34%), Positives = 90/165 (54%), Gaps = 1/165 (0%)

Query: 245 LDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPCWA-DSSKLVYTSAF 303
           L L  AG++TT   +++  L +L+  ++ E+++ EIE  IG   P    D +K+ YT A 
Sbjct: 293 LSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAV 352

Query: 304 LLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPER 363
           + E+ R   + P+  P  V Q T   GY+IPK+T V + L+    DP+ +  P    P+ 
Sbjct: 353 IYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDH 412

Query: 364 FIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKY 408
           F+D  G  K  E   PF  G+R C G+ +AR+ +F+ F  ILQ +
Sbjct: 413 FLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNF 457



 Score = 58.4 bits (135), Expect = 5e-08
 Identities = 49/182 (26%), Positives = 85/182 (46%), Gaps = 12/182 (6%)

Query: 33  MAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKN 92
           + PGP   P  G+   + QM  +     K+ L   +++   V  + LG   VV++ G + 
Sbjct: 30  LPPGPRPLPLLGN---LLQMDRR--GLLKSFLRFREKYG-DVFTVHLGPRPVVMLCGVEA 83

Query: 93  VRQVFSESE--FDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTS 150
           +R+   +    F GR           G   GV F +G  W+  R+F+V  +++ G GK S
Sbjct: 84  IREALVDKAEAFSGRGKIAMVDPFFRG--YGVIFANGNRWKVLRRFSVTTMRDFGMGKRS 141

Query: 151 MELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERI--REDKLERLLEL 208
           +E  IQ E + L E +  +K   +    +F S   N++   V G+R   ++ +  ++L L
Sbjct: 142 VEERIQEEAQCLIEELRKSKGALMDPTFLFHSITANIICSIVFGKRFHYQDQEFLKMLNL 201

Query: 209 FY 210
           FY
Sbjct: 202 FY 203


>AF182277-1|AAF13602.1|  491|Homo sapiens cytochrome P450-2B6
           protein.
          Length = 491

 Score =  119 bits (287), Expect = 2e-26
 Identities = 57/165 (34%), Positives = 90/165 (54%), Gaps = 1/165 (0%)

Query: 245 LDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPCWA-DSSKLVYTSAF 303
           L L  AG++TT   +++  L +L+  ++ E+++ EIE  IG   P    D +K+ YT A 
Sbjct: 293 LSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAV 352

Query: 304 LLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPER 363
           + E+ R   + P+  P  V Q T   GY+IPK+T V + L+    DP+ +  P    P+ 
Sbjct: 353 IYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDH 412

Query: 364 FIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKY 408
           F+D  G  K  E   PF  G+R C G+ +AR+ +F+ F  ILQ +
Sbjct: 413 FLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNF 457



 Score = 57.2 bits (132), Expect = 1e-07
 Identities = 48/182 (26%), Positives = 84/182 (46%), Gaps = 12/182 (6%)

Query: 33  MAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKN 92
           + PGP   P  G+   + QM  +     K+ L   +++   V  + LG   VV++ G + 
Sbjct: 30  LPPGPRPLPLLGN---LLQMDRR--GLLKSFLRFREKYG-DVFTVHLGPRPVVMLCGVEA 83

Query: 93  VRQVFSESE--FDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTS 150
           +R+   +    F GR           G   GV F +G  W+  R+F+V  +++ G GK S
Sbjct: 84  IREALVDKAEAFSGRGKIAMVDPFFRG--YGVIFANGNRWKVLRRFSVTTMRDFGMGKRS 141

Query: 151 MELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERI--REDKLERLLEL 208
           +E   Q E + L E +  +K   +    +F S   N++   V G+R   ++ +  ++L L
Sbjct: 142 VEERTQEEAQCLIEELRKSKGALMDATFLFHSITANIICSIVFGKRFHYQDQEFLKMLNL 201

Query: 209 FY 210
           FY
Sbjct: 202 FY 203


>AC023172-1|AAF32444.1|  491|Homo sapiens CYP2B6 protein.
          Length = 491

 Score =  119 bits (287), Expect = 2e-26
 Identities = 57/165 (34%), Positives = 90/165 (54%), Gaps = 1/165 (0%)

Query: 245 LDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPCWA-DSSKLVYTSAF 303
           L L  AG++TT   +++  L +L+  ++ E+++ EIE  IG   P    D +K+ YT A 
Sbjct: 293 LSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAV 352

Query: 304 LLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPER 363
           + E+ R   + P+  P  V Q T   GY+IPK+T V + L+    DP+ +  P    P+ 
Sbjct: 353 IYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDH 412

Query: 364 FIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKY 408
           F+D  G  K  E   PF  G+R C G+ +AR+ +F+ F  ILQ +
Sbjct: 413 FLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNF 457



 Score = 58.8 bits (136), Expect = 4e-08
 Identities = 49/182 (26%), Positives = 85/182 (46%), Gaps = 12/182 (6%)

Query: 33  MAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKN 92
           + PGP   P  G+   + QM  +     K+ L   +++   V  + LG   VV++ G + 
Sbjct: 30  LPPGPRPLPLLGN---LLQMDRR--GLLKSFLRFREKYG-DVFTVHLGPRPVVMLCGVEA 83

Query: 93  VRQVFSESE--FDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTS 150
           +R+   +    F GR           G   GV F +G  W+  R+F+V  +++ G GK S
Sbjct: 84  IREALVDKAEAFSGRGKIAMVDPFFRG--YGVIFANGNRWKVLRRFSVTTMRDFGMGKRS 141

Query: 151 MELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERI--REDKLERLLEL 208
           +E  IQ E + L E +  +K   +    +F S   N++   V G+R   ++ +  ++L L
Sbjct: 142 VEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNL 201

Query: 209 FY 210
           FY
Sbjct: 202 FY 203


>AB209492-1|BAD92729.1|  566|Homo sapiens Debrisoquine 4-hydroxylase
           mutant allele variant protein.
          Length = 566

 Score =  119 bits (287), Expect = 2e-26
 Identities = 63/199 (31%), Positives = 100/199 (50%), Gaps = 2/199 (1%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGD-SMPCWADSS 295
           ++ L+ V  DL  AG  TT   + + LL ++ + ++Q ++  EI++ IG    P   D +
Sbjct: 361 DENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQA 420

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
            + YT+A + EV R   I PL       +D  + G+ IPK TT++ +L+ +  D  +W  
Sbjct: 421 HMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEK 480

Query: 356 PHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNG 415
           P    PE F+D +G     E   PF +GRR C G+ LAR  +F+ F  +LQ +      G
Sbjct: 481 PFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG 540

Query: 416 -VLPSNEADIGLLAAPKPF 433
              PS+      L  P P+
Sbjct: 541 QPRPSHHGVFAFLVTPSPY 559



 Score = 49.2 bits (112), Expect = 3e-05
 Identities = 46/167 (27%), Positives = 71/167 (42%), Gaps = 7/167 (4%)

Query: 64  LELSKQWSTQVLGLKLGRELVVVVYGEKNVRQVFSESEFD--GRPNSFFYKLRCLGKRLG 121
           L+L +++   V  L+L    VVV+ G   VR+       D   RP     ++   G R  
Sbjct: 129 LQLRRRFG-DVFSLQLAWTPVVVLNGLAAVREAMVTRGEDTADRPPVPITQILGFGPRSQ 187

Query: 122 VTFVD--GPLWREHRQFTVKHLKNVGFGKTSMELEIQNELKLLREYINDNKHKPIKVDSM 179
             F+   GP WRE R+F+V  L+N+G GK S+E  +  E   L     ++   P    ++
Sbjct: 188 GVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSDAPF-APTV 246

Query: 180 FSSAVMNVLWKYVAGERIREDKLERLLELFYLRSKAFTLTGGLLSKI 226
             +   NV+     G R   D   R L L  L  +      G L ++
Sbjct: 247 SWTKPSNVIASLTCGRRFEYDD-PRFLRLLDLAQEGLKEESGFLREV 292


>L07093-1|AAA36660.1|  468|Homo sapiens cytochrome P450 protein.
          Length = 468

 Score =  119 bits (286), Expect = 2e-26
 Identities = 60/174 (34%), Positives = 93/174 (53%), Gaps = 1/174 (0%)

Query: 238 DQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSK 296
           + L     DL+ AG++TT   +++ALL +L++  +  K+  EIE  +G +  PC  D   
Sbjct: 263 ENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGH 322

Query: 297 LVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDP 356
           + YT A + EV R   + P + P  V  D     Y+IPK TT+L SL  +  D   +P+P
Sbjct: 323 MPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNP 382

Query: 357 HEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRI 410
               P  F+DE G  K + +  PF +G+R C G+ LAR  +F+    ILQ + +
Sbjct: 383 EMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNL 436



 Score = 59.7 bits (138), Expect = 2e-08
 Identities = 40/134 (29%), Positives = 66/134 (49%), Gaps = 5/134 (3%)

Query: 65  ELSKQWSTQVLGLKLGRELVVVVYGEKNVRQVFSE--SEFDGRPNSFFYKLRCLGKRLGV 122
           +LSK +   V  L  G E +VV++G + V++   +   EF GR +  F       +  G+
Sbjct: 34  QLSKIYGP-VFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGH--FPLAERANRGFGI 90

Query: 123 TFVDGPLWREHRQFTVKHLKNVGFGKTSMELEIQNELKLLREYINDNKHKPIKVDSMFSS 182
            F +G  W+E R+F++  L+N G GK S+E  +Q E + L E +   K  P     +   
Sbjct: 91  VFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGC 150

Query: 183 AVMNVLWKYVAGER 196
           A  NV+   +  +R
Sbjct: 151 APCNVICSIIFQKR 164


>AY796203-1|AAV41877.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 19 protein.
          Length = 490

 Score =  119 bits (286), Expect = 2e-26
 Identities = 60/174 (34%), Positives = 93/174 (53%), Gaps = 1/174 (0%)

Query: 238 DQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSK 296
           + L     DL+ AG++TT   +++ALL +L++  +  K+  EIE  +G +  PC  D   
Sbjct: 285 ENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGH 344

Query: 297 LVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDP 356
           + YT A + EV R   + P + P  V  D     Y+IPK TT+L SL  +  D   +P+P
Sbjct: 345 MPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNP 404

Query: 357 HEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRI 410
               P  F+DE G  K + +  PF +G+R C G+ LAR  +F+    ILQ + +
Sbjct: 405 EMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNL 458



 Score = 66.1 bits (154), Expect = 2e-10
 Identities = 50/166 (30%), Positives = 80/166 (48%), Gaps = 10/166 (6%)

Query: 33  MAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKN 92
           + PGP   P  G+   + Q+  K  S  K+L  LSK +   V  L  G E +VV++G + 
Sbjct: 29  LPPGPTPLPVIGN---ILQIDIKDVS--KSLTNLSKIYGP-VFTLYFGLERMVVLHGYEV 82

Query: 93  VRQVFSE--SEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTS 150
           V++   +   EF GR +  F       +  G+ F +G  W+E R+F++  L+N G GK S
Sbjct: 83  VKEALIDLGEEFSGRGH--FPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRS 140

Query: 151 MELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGER 196
           +E  +Q E + L E +   K  P     +   A  NV+   +  +R
Sbjct: 141 IEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKR 186


>AL583836-2|CAH74068.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 19 protein.
          Length = 490

 Score =  119 bits (286), Expect = 2e-26
 Identities = 60/174 (34%), Positives = 93/174 (53%), Gaps = 1/174 (0%)

Query: 238 DQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSK 296
           + L     DL+ AG++TT   +++ALL +L++  +  K+  EIE  +G +  PC  D   
Sbjct: 285 ENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGH 344

Query: 297 LVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDP 356
           + YT A + EV R   + P + P  V  D     Y+IPK TT+L SL  +  D   +P+P
Sbjct: 345 MPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNP 404

Query: 357 HEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRI 410
               P  F+DE G  K + +  PF +G+R C G+ LAR  +F+    ILQ + +
Sbjct: 405 EMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNL 458



 Score = 66.1 bits (154), Expect = 2e-10
 Identities = 50/166 (30%), Positives = 80/166 (48%), Gaps = 10/166 (6%)

Query: 33  MAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKN 92
           + PGP   P  G+   + Q+  K  S  K+L  LSK +   V  L  G E +VV++G + 
Sbjct: 29  LPPGPTPLPVIGN---ILQIDIKDVS--KSLTNLSKIYGP-VFTLYFGLERMVVLHGYEV 82

Query: 93  VRQVFSE--SEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTS 150
           V++   +   EF GR +  F       +  G+ F +G  W+E R+F++  L+N G GK S
Sbjct: 83  VKEALIDLGEEFSGRGH--FPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRS 140

Query: 151 MELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGER 196
           +E  +Q E + L E +   K  P     +   A  NV+   +  +R
Sbjct: 141 IEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKR 186


>AL133513-2|CAH73444.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 19 protein.
          Length = 490

 Score =  119 bits (286), Expect = 2e-26
 Identities = 60/174 (34%), Positives = 93/174 (53%), Gaps = 1/174 (0%)

Query: 238 DQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSK 296
           + L     DL+ AG++TT   +++ALL +L++  +  K+  EIE  +G +  PC  D   
Sbjct: 285 ENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGH 344

Query: 297 LVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDP 356
           + YT A + EV R   + P + P  V  D     Y+IPK TT+L SL  +  D   +P+P
Sbjct: 345 MPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNP 404

Query: 357 HEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRI 410
               P  F+DE G  K + +  PF +G+R C G+ LAR  +F+    ILQ + +
Sbjct: 405 EMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNL 458



 Score = 66.1 bits (154), Expect = 2e-10
 Identities = 50/166 (30%), Positives = 80/166 (48%), Gaps = 10/166 (6%)

Query: 33  MAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKN 92
           + PGP   P  G+   + Q+  K  S  K+L  LSK +   V  L  G E +VV++G + 
Sbjct: 29  LPPGPTPLPVIGN---ILQIDIKDVS--KSLTNLSKIYGP-VFTLYFGLERMVVLHGYEV 82

Query: 93  VRQVFSE--SEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTS 150
           V++   +   EF GR +  F       +  G+ F +G  W+E R+F++  L+N G GK S
Sbjct: 83  VKEALIDLGEEFSGRGH--FPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRS 140

Query: 151 MELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGER 196
           +E  +Q E + L E +   K  P     +   A  NV+   +  +R
Sbjct: 141 IEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKR 186


>X65962-1|CAA46778.1|  356|Homo sapiens cytochrome P-450 II C
           protein.
          Length = 356

 Score =  118 bits (285), Expect = 3e-26
 Identities = 60/174 (34%), Positives = 93/174 (53%), Gaps = 1/174 (0%)

Query: 238 DQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSK 296
           + L     DL+ AG++TT   +++ALL +L++  +  K+  EIE  +G +  PC  D   
Sbjct: 151 ENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGH 210

Query: 297 LVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDP 356
           + YT A + EV R   + P + P  V  D     Y+IPK TT+L SL  +  D   +P+P
Sbjct: 211 MPYTDAVVHEVQRYIDLIPTSLPHAVTCDIKFRNYLIPKGTTILTSLTSVLHDNKEFPNP 270

Query: 357 HEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRI 410
               P  F+DE G  K + +  PF +G+R C G+ LAR  +F+    ILQ + +
Sbjct: 271 EMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNL 324


>M61858-1|AAA52145.1|  370|Homo sapiens CYP2C17 protein.
          Length = 370

 Score =  118 bits (285), Expect = 3e-26
 Identities = 60/174 (34%), Positives = 93/174 (53%), Gaps = 1/174 (0%)

Query: 238 DQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSK 296
           + L     D+  AG++TT   +++ALL +L++  +  K+  EIE  +G +  PC  D S 
Sbjct: 165 ESLIATVTDMFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRSH 224

Query: 297 LVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDP 356
           + YT A + EV R   + P + P  V  D     Y+IPK TT+L SL  +  D   +P+P
Sbjct: 225 MPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNP 284

Query: 357 HEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRI 410
               P  F+DE G  K + +  PF +G+R C G+ LAR  +F+    ILQ + +
Sbjct: 285 EMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNL 338



 Score = 34.3 bits (75), Expect = 0.87
 Identities = 19/66 (28%), Positives = 31/66 (46%)

Query: 131 REHRQFTVKHLKNVGFGKTSMELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWK 190
           +E R+F +  L+N G GK S+E  +Q E + L E +      P     +   A  NV+  
Sbjct: 1   KEIRRFCLITLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICS 60

Query: 191 YVAGER 196
            +  +R
Sbjct: 61  IIFHKR 66


>X13930-1|CAA32118.1|  494|Homo sapiens protein ( Human CYP2A4 mRNA
           for P-450 IIA4 protein. ).
          Length = 494

 Score =  118 bits (283), Expect = 5e-26
 Identities = 55/199 (27%), Positives = 106/199 (53%), Gaps = 3/199 (1%)

Query: 245 LDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDS-MPCWADSSKLVYTSAF 303
           L+L I G++T    +++  L ++++  ++ K+  EI+  IG +  P + D +K+ Y  A 
Sbjct: 296 LNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAV 355

Query: 304 LLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPER 363
           + E+ R   + P++  RRV +DT    + +PK T V   L  +  DP+ + +P +  P+ 
Sbjct: 356 IHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQH 415

Query: 364 FIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGV--LPSNE 421
           F++EKG  K ++   PF  G+R C G+ LAR  +F+ F  ++Q +R+        +  + 
Sbjct: 416 FLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSP 475

Query: 422 ADIGLLAAPKPFVANFVSR 440
             +G    P+ +  +F+ R
Sbjct: 476 KHVGFATIPRNYTMSFLPR 494



 Score = 56.0 bits (129), Expect = 2e-07
 Identities = 52/189 (27%), Positives = 85/189 (44%), Gaps = 11/189 (5%)

Query: 33  MAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKN 92
           + PGP   PF G+   +Q  T +    + +L+++S+++   V  + LG   VVV+ G   
Sbjct: 33  LPPGPTPLPFIGN--YLQLNTEQ---MYNSLMKISERYGP-VFTIHLGPRRVVVLCGHDA 86

Query: 93  VRQVFSES--EFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTS 150
           VR+   +   EF GR     +    + K  GV F +G   ++ R+F++  L++ G GK  
Sbjct: 87  VREALVDQAEEFSGRGEQATFDW--VFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRG 144

Query: 151 MELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERIREDKLERLLELFY 210
           +E  IQ E   L +         I      S  V NV+   V G+R  + K +  L L  
Sbjct: 145 IEERIQEEAGFLIDAHRGTGGANIDPTFFLSRTVSNVISSIVFGDRF-DYKDKEFLSLLR 203

Query: 211 LRSKAFTLT 219
           +    F  T
Sbjct: 204 MMLGIFQFT 212


>X13929-1|CAA32117.1|  448|Homo sapiens P-450 IIA3 protein (1 is 3rd
           base in codon) protein.
          Length = 448

 Score =  118 bits (283), Expect = 5e-26
 Identities = 55/199 (27%), Positives = 106/199 (53%), Gaps = 3/199 (1%)

Query: 245 LDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDS-MPCWADSSKLVYTSAF 303
           L+L I G++T    +++  L ++++  ++ K+  EI+  IG +  P + D +K+ Y  A 
Sbjct: 250 LNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAV 309

Query: 304 LLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPER 363
           + E+ R   + P++  RRV +DT    + +PK T V   L  +  DP+ + +P +  P+ 
Sbjct: 310 IHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQH 369

Query: 364 FIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGV--LPSNE 421
           F++EKG  K ++   PF  G+R C G+ LAR  +F+ F  ++Q +R+        +  + 
Sbjct: 370 FLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSP 429

Query: 422 ADIGLLAAPKPFVANFVSR 440
             +G    P+ +  +F+ R
Sbjct: 430 KHVGFATIPRNYTMSFLPR 448



 Score = 52.4 bits (120), Expect = 3e-06
 Identities = 44/162 (27%), Positives = 74/162 (45%), Gaps = 6/162 (3%)

Query: 60  WKALLELSKQWSTQVLGLKLGRELVVVVYGEKNVRQVFSES--EFDGRPNSFFYKLRCLG 117
           + +L+++S+++   V  + LG   VVV+ G   VR+   +   EF GR     +    + 
Sbjct: 9   YNSLMKISERYGP-VFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDW--VF 65

Query: 118 KRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTSMELEIQNELKLLREYINDNKHKPIKVD 177
           K  GV F +G   ++ R+F++  L++ G GK  +E  IQ E   L + +       I   
Sbjct: 66  KGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPT 125

Query: 178 SMFSSAVMNVLWKYVAGERIREDKLERLLELFYLRSKAFTLT 219
              S  V NV+   V G+R  + K +  L L  +    F  T
Sbjct: 126 FFLSRTVSNVISSIVFGDRF-DYKDKEFLSLLRMMLGIFQFT 166


>M33318-1|AAA52067.1|  494|Homo sapiens CYP2A protein.
          Length = 494

 Score =  118 bits (283), Expect = 5e-26
 Identities = 55/199 (27%), Positives = 106/199 (53%), Gaps = 3/199 (1%)

Query: 245 LDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDS-MPCWADSSKLVYTSAF 303
           L+L I G++T    +++  L ++++  ++ K+  EI+  IG +  P + D +K+ Y  A 
Sbjct: 296 LNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAV 355

Query: 304 LLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPER 363
           + E+ R   + P++  RRV +DT    + +PK T V   L  +  DP+ + +P +  P+ 
Sbjct: 356 IHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQH 415

Query: 364 FIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGV--LPSNE 421
           F++EKG  K ++   PF  G+R C G+ LAR  +F+ F  ++Q +R+        +  + 
Sbjct: 416 FLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSP 475

Query: 422 ADIGLLAAPKPFVANFVSR 440
             +G    P+ +  +F+ R
Sbjct: 476 KHVGFATIPRNYTMSFLPR 494



 Score = 58.0 bits (134), Expect = 6e-08
 Identities = 52/189 (27%), Positives = 86/189 (45%), Gaps = 11/189 (5%)

Query: 33  MAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKN 92
           + PGP   PF G+   +Q  T +    + +L+++S+++   V  + LG   VVV+ G   
Sbjct: 33  LPPGPTPLPFIGN--YLQLNTEQ---MYNSLMKISERYGP-VFTIHLGPRRVVVLCGHDA 86

Query: 93  VRQVFSES--EFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTS 150
           VR+   +   EF GR     +    + K  GV F +G   ++ R+F++  L++ G GK  
Sbjct: 87  VREALVDQAEEFSGRGEQATFDW--VFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRG 144

Query: 151 MELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERIREDKLERLLELFY 210
           +E  IQ E   L + +       I      S  V NV+   V G+R  + K +  L L  
Sbjct: 145 IEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRF-DYKDKEFLSLLR 203

Query: 211 LRSKAFTLT 219
           +    F  T
Sbjct: 204 MMLGIFQFT 212


>BC096256-1|AAH96256.1|  494|Homo sapiens cytochrome P450, family 2,
           subfamily A, polypeptide 6 protein.
          Length = 494

 Score =  118 bits (283), Expect = 5e-26
 Identities = 55/199 (27%), Positives = 106/199 (53%), Gaps = 3/199 (1%)

Query: 245 LDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDS-MPCWADSSKLVYTSAF 303
           L+L I G++T    +++  L ++++  ++ K+  EI+  IG +  P + D +K+ Y  A 
Sbjct: 296 LNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAV 355

Query: 304 LLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPER 363
           + E+ R   + P++  RRV +DT    + +PK T V   L  +  DP+ + +P +  P+ 
Sbjct: 356 IHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQH 415

Query: 364 FIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGV--LPSNE 421
           F++EKG  K ++   PF  G+R C G+ LAR  +F+ F  ++Q +R+        +  + 
Sbjct: 416 FLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSP 475

Query: 422 ADIGLLAAPKPFVANFVSR 440
             +G    P+ +  +F+ R
Sbjct: 476 RHVGFATIPRNYTMSFLPR 494



 Score = 58.0 bits (134), Expect = 6e-08
 Identities = 52/189 (27%), Positives = 86/189 (45%), Gaps = 11/189 (5%)

Query: 33  MAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKN 92
           + PGP   PF G+   +Q  T +    + +L+++S+++   V  + LG   VVV+ G   
Sbjct: 33  LPPGPTPLPFIGN--YLQLNTEQ---MYNSLMKISERYGP-VFTIHLGPRRVVVLCGHDA 86

Query: 93  VRQVFSES--EFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTS 150
           VR+   +   EF GR     +    + K  GV F +G   ++ R+F++  L++ G GK  
Sbjct: 87  VREALVDQAEEFSGRGEQATFDW--VFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRG 144

Query: 151 MELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERIREDKLERLLELFY 210
           +E  IQ E   L + +       I      S  V NV+   V G+R  + K +  L L  
Sbjct: 145 IEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRF-DYKDKEFLSLLR 203

Query: 211 LRSKAFTLT 219
           +    F  T
Sbjct: 204 MMLGIFQFT 212


>BC096255-1|AAH96255.1|  494|Homo sapiens cytochrome P450, family 2,
           subfamily A, polypeptide 6 protein.
          Length = 494

 Score =  118 bits (283), Expect = 5e-26
 Identities = 55/199 (27%), Positives = 106/199 (53%), Gaps = 3/199 (1%)

Query: 245 LDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDS-MPCWADSSKLVYTSAF 303
           L+L I G++T    +++  L ++++  ++ K+  EI+  IG +  P + D +K+ Y  A 
Sbjct: 296 LNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAV 355

Query: 304 LLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPER 363
           + E+ R   + P++  RRV +DT    + +PK T V   L  +  DP+ + +P +  P+ 
Sbjct: 356 IHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQH 415

Query: 364 FIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGV--LPSNE 421
           F++EKG  K ++   PF  G+R C G+ LAR  +F+ F  ++Q +R+        +  + 
Sbjct: 416 FLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSP 475

Query: 422 ADIGLLAAPKPFVANFVSR 440
             +G    P+ +  +F+ R
Sbjct: 476 KHVGFATIPRNYTMSFLPR 494



 Score = 56.0 bits (129), Expect = 2e-07
 Identities = 52/189 (27%), Positives = 85/189 (44%), Gaps = 11/189 (5%)

Query: 33  MAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKN 92
           + PGP   PF G+   +Q  T +    + +L+++S+++   V  + LG   VVV+ G   
Sbjct: 33  LPPGPTPLPFIGN--YLQLNTEQ---MYNSLMKISERYGP-VFTIHLGPRRVVVLCGHDA 86

Query: 93  VRQVFSES--EFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTS 150
           VR+   +   EF GR     +    + K  GV F +G   ++ R+F++  L++ G GK  
Sbjct: 87  VREALVDQAEEFSGRGEQATFDW--VFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRG 144

Query: 151 MELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERIREDKLERLLELFY 210
           +E  IQ E   L +         I      S  V NV+   V G+R  + K +  L L  
Sbjct: 145 IEERIQEEAGFLIDAHRGTGGANIDPTFFLSRTVSNVISSIVFGDRF-DYKDKEFLSLLR 203

Query: 211 LRSKAFTLT 219
           +    F  T
Sbjct: 204 MMLGIFQFT 212


>BC096254-1|AAH96254.1|  494|Homo sapiens cytochrome P450, family 2,
           subfamily A, polypeptide 6 protein.
          Length = 494

 Score =  118 bits (283), Expect = 5e-26
 Identities = 55/199 (27%), Positives = 106/199 (53%), Gaps = 3/199 (1%)

Query: 245 LDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDS-MPCWADSSKLVYTSAF 303
           L+L I G++T    +++  L ++++  ++ K+  EI+  IG +  P + D +K+ Y  A 
Sbjct: 296 LNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAV 355

Query: 304 LLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPER 363
           + E+ R   + P++  RRV +DT    + +PK T V   L  +  DP+ + +P +  P+ 
Sbjct: 356 IHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQH 415

Query: 364 FIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGV--LPSNE 421
           F++EKG  K ++   PF  G+R C G+ LAR  +F+ F  ++Q +R+        +  + 
Sbjct: 416 FLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSP 475

Query: 422 ADIGLLAAPKPFVANFVSR 440
             +G    P+ +  +F+ R
Sbjct: 476 KHVGFATIPRNYTMSFLPR 494



 Score = 58.0 bits (134), Expect = 6e-08
 Identities = 52/189 (27%), Positives = 86/189 (45%), Gaps = 11/189 (5%)

Query: 33  MAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKN 92
           + PGP   PF G+   +Q  T +    + +L+++S+++   V  + LG   VVV+ G   
Sbjct: 33  LPPGPTPLPFIGN--YLQLNTEQ---MYNSLMKISERYGP-VFTIHLGPRRVVVLCGHDA 86

Query: 93  VRQVFSES--EFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTS 150
           VR+   +   EF GR     +    + K  GV F +G   ++ R+F++  L++ G GK  
Sbjct: 87  VREALVDQAEEFSGRGEQATFDW--VFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRG 144

Query: 151 MELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERIREDKLERLLELFY 210
           +E  IQ E   L + +       I      S  V NV+   V G+R  + K +  L L  
Sbjct: 145 IEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRF-DYKDKEFLSLLR 203

Query: 211 LRSKAFTLT 219
           +    F  T
Sbjct: 204 MMLGIFQFT 212


>BC096253-1|AAH96253.3|  494|Homo sapiens cytochrome P450, family 2,
           subfamily A, polypeptide 6 protein.
          Length = 494

 Score =  118 bits (283), Expect = 5e-26
 Identities = 55/199 (27%), Positives = 106/199 (53%), Gaps = 3/199 (1%)

Query: 245 LDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDS-MPCWADSSKLVYTSAF 303
           L+L I G++T    +++  L ++++  ++ K+  EI+  IG +  P + D +K+ Y  A 
Sbjct: 296 LNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAV 355

Query: 304 LLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPER 363
           + E+ R   + P++  RRV +DT    + +PK T V   L  +  DP+ + +P +  P+ 
Sbjct: 356 IHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQH 415

Query: 364 FIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGV--LPSNE 421
           F++EKG  K ++   PF  G+R C G+ LAR  +F+ F  ++Q +R+        +  + 
Sbjct: 416 FLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSP 475

Query: 422 ADIGLLAAPKPFVANFVSR 440
             +G    P+ +  +F+ R
Sbjct: 476 KHVGFATIPRNYTMSFLPR 494



 Score = 58.0 bits (134), Expect = 6e-08
 Identities = 52/189 (27%), Positives = 86/189 (45%), Gaps = 11/189 (5%)

Query: 33  MAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKN 92
           + PGP   PF G+   +Q  T +    + +L+++S+++   V  + LG   VVV+ G   
Sbjct: 33  LPPGPTPLPFIGN--YLQLNTEQ---MYNSLMKISERYGP-VFTIHLGPRRVVVLCGHDA 86

Query: 93  VRQVFSES--EFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTS 150
           VR+   +   EF GR     +    + K  GV F +G   ++ R+F++  L++ G GK  
Sbjct: 87  VREALVDQAEEFSGRGEQATFDW--VFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRG 144

Query: 151 MELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERIREDKLERLLELFY 210
           +E  IQ E   L + +       I      S  V NV+   V G+R  + K +  L L  
Sbjct: 145 IEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRF-DYKDKEFLSLLR 203

Query: 211 LRSKAFTLT 219
           +    F  T
Sbjct: 204 MMLGIFQFT 212


>DQ282162-1|ABB77909.1|  500|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 500

 Score =  117 bits (282), Expect = 7e-26
 Identities = 63/199 (31%), Positives = 99/199 (49%), Gaps = 2/199 (1%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGD-SMPCWADSS 295
           ++ L  V  DL  AG  TT   + + LL ++ + ++Q ++  EI++ IG    P   D +
Sbjct: 295 DENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQA 354

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
            + YT+A + EV R   I PL       +D  + G+ IPK TT++ +L+ +  D  +W  
Sbjct: 355 HMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEK 414

Query: 356 PHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNG 415
           P    PE F+D +G     E   PF +GRR C G+ LAR  +F+ F  +LQ +      G
Sbjct: 415 PFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG 474

Query: 416 -VLPSNEADIGLLAAPKPF 433
              PS+      L  P P+
Sbjct: 475 QPRPSHHGVFAFLVTPSPY 493



 Score = 56.0 bits (129), Expect = 2e-07
 Identities = 47/160 (29%), Positives = 69/160 (43%), Gaps = 8/160 (5%)

Query: 74  VLGLKLGRELVVVVYGEKNVRQVFSESEFD--GRPNSFFYKLRCLGKRLGVTFVD--GPL 129
           V  L+L    VVV+ G   VR+       D   RP     ++   G R    F+   GP 
Sbjct: 68  VFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPIIQILGFGPRSQGVFLARYGPA 127

Query: 130 WREHRQFTVKHLKNVGFGKTSMELEIQNELK-LLREYINDN--KHKPIKVDSMFSSAVMN 186
           WRE R+F+V  L+N+G GK S+E  +  E   L   + N +    +P + + +   AV N
Sbjct: 128 WREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPFRPNGLLDKAVSN 187

Query: 187 VLWKYVAGERIREDKLERLLELFYLRSKAFTLTGGLLSKI 226
           V+     G R   D   R L L  L  +      G L ++
Sbjct: 188 VIASLTCGRRFEYDD-PRFLRLLDLAQEGLKEESGFLREV 226


>DQ282160-1|ABB77908.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score =  117 bits (282), Expect = 7e-26
 Identities = 63/199 (31%), Positives = 99/199 (49%), Gaps = 2/199 (1%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGD-SMPCWADSS 295
           ++ L  V  DL  AG  TT   + + LL ++ + ++Q ++  EI++ IG    P   D +
Sbjct: 292 DENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQA 351

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
            + YT+A + EV R   I PL       +D  + G+ IPK TT++ +L+ +  D  +W  
Sbjct: 352 HMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEK 411

Query: 356 PHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNG 415
           P    PE F+D +G     E   PF +GRR C G+ LAR  +F+ F  +LQ +      G
Sbjct: 412 PFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG 471

Query: 416 -VLPSNEADIGLLAAPKPF 433
              PS+      L  P P+
Sbjct: 472 QPRPSHHGVFAFLVTPSPY 490



 Score = 60.5 bits (140), Expect = 1e-08
 Identities = 46/157 (29%), Positives = 68/157 (43%), Gaps = 5/157 (3%)

Query: 74  VLGLKLGRELVVVVYGEKNVRQVFSESEFD--GRPNSFFYKLRCLGKRLGVTFVD--GPL 129
           V  L+L    VVV+ G   VR+       D   RP     ++   G R    F+   GP 
Sbjct: 68  VFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPA 127

Query: 130 WREHRQFTVKHLKNVGFGKTSMELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLW 189
           WRE R+F+V  L+N+G GK S+E  +  E   L     ++  +P + + +   AV NV+ 
Sbjct: 128 WREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIA 187

Query: 190 KYVAGERIREDKLERLLELFYLRSKAFTLTGGLLSKI 226
               G R   D   R L L  L  +      G L ++
Sbjct: 188 SLTCGRRFEYDD-PRFLRLLDLAQEGLKEESGFLREV 223


>DQ282159-1|ABB77907.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score =  117 bits (282), Expect = 7e-26
 Identities = 63/199 (31%), Positives = 99/199 (49%), Gaps = 2/199 (1%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGD-SMPCWADSS 295
           ++ L  V  DL  AG  TT   + + LL ++ + ++Q ++  EI++ IG    P   D +
Sbjct: 292 DENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQA 351

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
            + YT+A + EV R   I PL       +D  + G+ IPK TT++ +L+ +  D  +W  
Sbjct: 352 HMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEK 411

Query: 356 PHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNG 415
           P    PE F+D +G     E   PF +GRR C G+ LAR  +F+ F  +LQ +      G
Sbjct: 412 PFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG 471

Query: 416 -VLPSNEADIGLLAAPKPF 433
              PS+      L  P P+
Sbjct: 472 QPRPSHHGVFAFLVTPSPY 490



 Score = 60.5 bits (140), Expect = 1e-08
 Identities = 46/157 (29%), Positives = 68/157 (43%), Gaps = 5/157 (3%)

Query: 74  VLGLKLGRELVVVVYGEKNVRQVFSESEFD--GRPNSFFYKLRCLGKRLGVTFVD--GPL 129
           V  L+L    VVV+ G   VR+       D   RP     ++   G R    F+   GP 
Sbjct: 68  VFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPA 127

Query: 130 WREHRQFTVKHLKNVGFGKTSMELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLW 189
           WRE R+F+V  L+N+G GK S+E  +  E   L     ++  +P + + +   AV NV+ 
Sbjct: 128 WREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIA 187

Query: 190 KYVAGERIREDKLERLLELFYLRSKAFTLTGGLLSKI 226
               G R   D   R L L  L  +      G L ++
Sbjct: 188 SLTCGRRFEYDD-PRFLRLLDLAQEGLKEESGFLREV 223


>DQ282158-1|ABB77906.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score =  117 bits (282), Expect = 7e-26
 Identities = 63/199 (31%), Positives = 99/199 (49%), Gaps = 2/199 (1%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGD-SMPCWADSS 295
           ++ L  V  DL  AG  TT   + + LL ++ + ++Q ++  EI++ IG    P   D +
Sbjct: 292 DENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQA 351

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
            + YT+A + EV R   I PL       +D  + G+ IPK TT++ +L+ +  D  +W  
Sbjct: 352 HMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEK 411

Query: 356 PHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNG 415
           P    PE F+D +G     E   PF +GRR C G+ LAR  +F+ F  +LQ +      G
Sbjct: 412 PFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG 471

Query: 416 -VLPSNEADIGLLAAPKPF 433
              PS+      L  P P+
Sbjct: 472 QPRPSHHGVFAFLVTPSPY 490



 Score = 60.9 bits (141), Expect = 9e-09
 Identities = 46/157 (29%), Positives = 68/157 (43%), Gaps = 5/157 (3%)

Query: 74  VLGLKLGRELVVVVYGEKNVRQVFSESEFD--GRPNSFFYKLRCLGKRLGVTFVD--GPL 129
           V  L+L    VVV+ G   VR+       D   RP     ++   G R    F+   GP 
Sbjct: 68  VFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPIIQILGFGPRSQGVFLARYGPA 127

Query: 130 WREHRQFTVKHLKNVGFGKTSMELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLW 189
           WRE R+F+V  L+N+G GK S+E  +  E   L     ++  +P + + +   AV NV+ 
Sbjct: 128 WREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIA 187

Query: 190 KYVAGERIREDKLERLLELFYLRSKAFTLTGGLLSKI 226
               G R   D   R L L  L  +      G L ++
Sbjct: 188 SLTCGRRFEYDD-PRFLRLLDLAQEGLKEESGFLREV 223


>DQ282157-1|ABB77905.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score =  117 bits (282), Expect = 7e-26
 Identities = 63/199 (31%), Positives = 99/199 (49%), Gaps = 2/199 (1%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGD-SMPCWADSS 295
           ++ L  V  DL  AG  TT   + + LL ++ + ++Q ++  EI++ IG    P   D +
Sbjct: 292 DENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQA 351

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
            + YT+A + EV R   I PL       +D  + G+ IPK TT++ +L+ +  D  +W  
Sbjct: 352 HMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEK 411

Query: 356 PHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNG 415
           P    PE F+D +G     E   PF +GRR C G+ LAR  +F+ F  +LQ +      G
Sbjct: 412 PFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG 471

Query: 416 -VLPSNEADIGLLAAPKPF 433
              PS+      L  P P+
Sbjct: 472 QPRPSHHGVFAFLVTPSPY 490



 Score = 60.9 bits (141), Expect = 9e-09
 Identities = 46/157 (29%), Positives = 68/157 (43%), Gaps = 5/157 (3%)

Query: 74  VLGLKLGRELVVVVYGEKNVRQVFSESEFD--GRPNSFFYKLRCLGKRLGVTFVD--GPL 129
           V  L+L    VVV+ G   VR+       D   RP     ++   G R    F+   GP 
Sbjct: 68  VFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPIIQILGFGPRSQGVFLARYGPA 127

Query: 130 WREHRQFTVKHLKNVGFGKTSMELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLW 189
           WRE R+F+V  L+N+G GK S+E  +  E   L     ++  +P + + +   AV NV+ 
Sbjct: 128 WREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIA 187

Query: 190 KYVAGERIREDKLERLLELFYLRSKAFTLTGGLLSKI 226
               G R   D   R L L  L  +      G L ++
Sbjct: 188 SLTCGRRFEYDD-PRFLRLLDLAQEGLKEESGFLREV 223


>DQ282156-1|ABB77904.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score =  117 bits (282), Expect = 7e-26
 Identities = 63/199 (31%), Positives = 99/199 (49%), Gaps = 2/199 (1%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGD-SMPCWADSS 295
           ++ L  V  DL  AG  TT   + + LL ++ + ++Q ++  EI++ IG    P   D +
Sbjct: 292 DENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQA 351

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
            + YT+A + EV R   I PL       +D  + G+ IPK TT++ +L+ +  D  +W  
Sbjct: 352 HMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEK 411

Query: 356 PHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNG 415
           P    PE F+D +G     E   PF +GRR C G+ LAR  +F+ F  +LQ +      G
Sbjct: 412 PFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG 471

Query: 416 -VLPSNEADIGLLAAPKPF 433
              PS+      L  P P+
Sbjct: 472 QPRPSHHGVFAFLVTPSPY 490



 Score = 60.5 bits (140), Expect = 1e-08
 Identities = 46/157 (29%), Positives = 68/157 (43%), Gaps = 5/157 (3%)

Query: 74  VLGLKLGRELVVVVYGEKNVRQVFSESEFD--GRPNSFFYKLRCLGKRLGVTFVD--GPL 129
           V  L+L    VVV+ G   VR+       D   RP     ++   G R    F+   GP 
Sbjct: 68  VFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPA 127

Query: 130 WREHRQFTVKHLKNVGFGKTSMELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLW 189
           WRE R+F+V  L+N+G GK S+E  +  E   L     ++  +P + + +   AV NV+ 
Sbjct: 128 WREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIA 187

Query: 190 KYVAGERIREDKLERLLELFYLRSKAFTLTGGLLSKI 226
               G R   D   R L L  L  +      G L ++
Sbjct: 188 SLTCGRRFEYDD-PRFLRLLDLAQEGLKEESGFLREV 223


>DQ282155-1|ABB77903.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score =  117 bits (282), Expect = 7e-26
 Identities = 63/199 (31%), Positives = 99/199 (49%), Gaps = 2/199 (1%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGD-SMPCWADSS 295
           ++ L  V  DL  AG  TT   + + LL ++ + ++Q ++  EI++ IG    P   D +
Sbjct: 292 DENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQA 351

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
            + YT+A + EV R   I PL       +D  + G+ IPK TT++ +L+ +  D  +W  
Sbjct: 352 HMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEK 411

Query: 356 PHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNG 415
           P    PE F+D +G     E   PF +GRR C G+ LAR  +F+ F  +LQ +      G
Sbjct: 412 PFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG 471

Query: 416 -VLPSNEADIGLLAAPKPF 433
              PS+      L  P P+
Sbjct: 472 QPRPSHHGVFAFLVTPSPY 490



 Score = 60.5 bits (140), Expect = 1e-08
 Identities = 46/157 (29%), Positives = 68/157 (43%), Gaps = 5/157 (3%)

Query: 74  VLGLKLGRELVVVVYGEKNVRQVFSESEFD--GRPNSFFYKLRCLGKRLGVTFVD--GPL 129
           V  L+L    VVV+ G   VR+       D   RP     ++   G R    F+   GP 
Sbjct: 68  VFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPA 127

Query: 130 WREHRQFTVKHLKNVGFGKTSMELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLW 189
           WRE R+F+V  L+N+G GK S+E  +  E   L     ++  +P + + +   AV NV+ 
Sbjct: 128 WREQRRFSVSTLRNLGLGKKSLEQWVTKEAACLCAAFANHSGRPFRPNGLLDKAVSNVIA 187

Query: 190 KYVAGERIREDKLERLLELFYLRSKAFTLTGGLLSKI 226
               G R   D   R L L  L  +      G L ++
Sbjct: 188 SLTCGRRFEYDD-PRFLRLLDLAQEGLKEESGFLREV 223


>DQ282147-1|ABB77898.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score =  117 bits (282), Expect = 7e-26
 Identities = 63/199 (31%), Positives = 99/199 (49%), Gaps = 2/199 (1%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGD-SMPCWADSS 295
           ++ L  V  DL  AG  TT   + + LL ++ + ++Q ++  EI++ IG    P   D +
Sbjct: 292 DENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQA 351

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
            + YT+A + EV R   I PL       +D  + G+ IPK TT++ +L+ +  D  +W  
Sbjct: 352 HMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEK 411

Query: 356 PHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNG 415
           P    PE F+D +G     E   PF +GRR C G+ LAR  +F+ F  +LQ +      G
Sbjct: 412 PFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG 471

Query: 416 -VLPSNEADIGLLAAPKPF 433
              PS+      L  P P+
Sbjct: 472 QPRPSHHGVFAFLVTPSPY 490



 Score = 60.5 bits (140), Expect = 1e-08
 Identities = 46/157 (29%), Positives = 68/157 (43%), Gaps = 5/157 (3%)

Query: 74  VLGLKLGRELVVVVYGEKNVRQVFSESEFD--GRPNSFFYKLRCLGKRLGVTFVD--GPL 129
           V  L+L    VVV+ G   VR+       D   RP     ++   G R    F+   GP 
Sbjct: 68  VFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPA 127

Query: 130 WREHRQFTVKHLKNVGFGKTSMELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLW 189
           WRE R+F+V  L+N+G GK S+E  +  E   L     ++  +P + + +   AV NV+ 
Sbjct: 128 WREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIA 187

Query: 190 KYVAGERIREDKLERLLELFYLRSKAFTLTGGLLSKI 226
               G R   D   R L L  L  +      G L ++
Sbjct: 188 SLTCGRRFEYDD-PRFLRLLDLAQEGLKEESGFLREV 223


>CR456430-1|CAG30316.1|  446|Homo sapiens CYP2D6 protein.
          Length = 446

 Score =  117 bits (282), Expect = 7e-26
 Identities = 63/199 (31%), Positives = 99/199 (49%), Gaps = 2/199 (1%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGD-SMPCWADSS 295
           ++ L  V  DL  AG  TT   + + LL ++ + ++Q ++  EI++ IG    P   D +
Sbjct: 241 DENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQA 300

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
            + YT+A + EV R   I PL       +D  + G+ IPK TT++ +L+ +  D  +W  
Sbjct: 301 HMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEK 360

Query: 356 PHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNG 415
           P    PE F+D +G     E   PF +GRR C G+ LAR  +F+ F  +LQ +      G
Sbjct: 361 PFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG 420

Query: 416 -VLPSNEADIGLLAAPKPF 433
              PS+      L  P P+
Sbjct: 421 QPRPSHHGVFAFLVTPSPY 439


>BC126858-1|AAI26859.1|  497|Homo sapiens cytochrome P450, family 2,
           subfamily D, polypeptide 6 protein.
          Length = 497

 Score =  117 bits (282), Expect = 7e-26
 Identities = 63/199 (31%), Positives = 99/199 (49%), Gaps = 2/199 (1%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGD-SMPCWADSS 295
           ++ L  V  DL  AG  TT   + + LL ++ + ++Q ++  EI++ IG    P   D +
Sbjct: 292 DENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQA 351

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
            + YT+A + EV R   I PL       +D  + G+ IPK TT++ +L+ +  D  +W  
Sbjct: 352 HMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEK 411

Query: 356 PHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNG 415
           P    PE F+D +G     E   PF +GRR C G+ LAR  +F+ F  +LQ +      G
Sbjct: 412 PFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG 471

Query: 416 -VLPSNEADIGLLAAPKPF 433
              PS+      L  P P+
Sbjct: 472 QPRPSHHGVFAFLVTPSPY 490



 Score = 60.5 bits (140), Expect = 1e-08
 Identities = 46/157 (29%), Positives = 68/157 (43%), Gaps = 5/157 (3%)

Query: 74  VLGLKLGRELVVVVYGEKNVRQVFSESEFD--GRPNSFFYKLRCLGKRLGVTFVD--GPL 129
           V  L+L    VVV+ G   VR+       D   RP     ++   G R    F+   GP 
Sbjct: 68  VFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPA 127

Query: 130 WREHRQFTVKHLKNVGFGKTSMELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLW 189
           WRE R+F+V  L+N+G GK S+E  +  E   L     ++  +P + + +   AV NV+ 
Sbjct: 128 WREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIA 187

Query: 190 KYVAGERIREDKLERLLELFYLRSKAFTLTGGLLSKI 226
               G R   D   R L L  L  +      G L ++
Sbjct: 188 SLTCGRRFEYDD-PRFLRLLDLAQEGLKEESGFLREV 223


>BC106757-1|AAI06758.1|  446|Homo sapiens cytochrome P450, family 2,
           subfamily D, polypeptide 6 protein.
          Length = 446

 Score =  117 bits (282), Expect = 7e-26
 Identities = 63/199 (31%), Positives = 99/199 (49%), Gaps = 2/199 (1%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGD-SMPCWADSS 295
           ++ L  V  DL  AG  TT   + + LL ++ + ++Q ++  EI++ IG    P   D +
Sbjct: 241 DENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQA 300

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
            + YT+A + EV R   I PL       +D  + G+ IPK TT++ +L+ +  D  +W  
Sbjct: 301 HMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEK 360

Query: 356 PHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNG 415
           P    PE F+D +G     E   PF +GRR C G+ LAR  +F+ F  +LQ +      G
Sbjct: 361 PFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG 420

Query: 416 -VLPSNEADIGLLAAPKPF 433
              PS+      L  P P+
Sbjct: 421 QPRPSHHGVFAFLVTPSPY 439


>BC067432-1|AAH67432.1|  497|Homo sapiens cytochrome P450, family 2,
           subfamily D, polypeptide 6 protein.
          Length = 497

 Score =  117 bits (282), Expect = 7e-26
 Identities = 63/199 (31%), Positives = 99/199 (49%), Gaps = 2/199 (1%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGD-SMPCWADSS 295
           ++ L  V  DL  AG  TT   + + LL ++ + ++Q ++  EI++ IG    P   D +
Sbjct: 292 DENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQA 351

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
            + YT+A + EV R   I PL       +D  + G+ IPK TT++ +L+ +  D  +W  
Sbjct: 352 HMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEK 411

Query: 356 PHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNG 415
           P    PE F+D +G     E   PF +GRR C G+ LAR  +F+ F  +LQ +      G
Sbjct: 412 PFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG 471

Query: 416 -VLPSNEADIGLLAAPKPF 433
              PS+      L  P P+
Sbjct: 472 QPRPSHHGVFAFLVTPSPY 490



 Score = 60.5 bits (140), Expect = 1e-08
 Identities = 46/157 (29%), Positives = 68/157 (43%), Gaps = 5/157 (3%)

Query: 74  VLGLKLGRELVVVVYGEKNVRQVFSESEFD--GRPNSFFYKLRCLGKRLGVTFVD--GPL 129
           V  L+L    VVV+ G   VR+       D   RP     ++   G R    F+   GP 
Sbjct: 68  VFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPA 127

Query: 130 WREHRQFTVKHLKNVGFGKTSMELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLW 189
           WRE R+F+V  L+N+G GK S+E  +  E   L     ++  +P + + +   AV NV+ 
Sbjct: 128 WREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIA 187

Query: 190 KYVAGERIREDKLERLLELFYLRSKAFTLTGGLLSKI 226
               G R   D   R L L  L  +      G L ++
Sbjct: 188 SLTCGRRFEYDD-PRFLRLLDLAQEGLKEESGFLREV 223


>BC066877-1|AAH66877.1|  446|Homo sapiens CYP2D6 protein protein.
          Length = 446

 Score =  117 bits (282), Expect = 7e-26
 Identities = 63/199 (31%), Positives = 99/199 (49%), Gaps = 2/199 (1%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGD-SMPCWADSS 295
           ++ L  V  DL  AG  TT   + + LL ++ + ++Q ++  EI++ IG    P   D +
Sbjct: 241 DENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQA 300

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
            + YT+A + EV R   I PL       +D  + G+ IPK TT++ +L+ +  D  +W  
Sbjct: 301 HMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEK 360

Query: 356 PHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNG 415
           P    PE F+D +G     E   PF +GRR C G+ LAR  +F+ F  +LQ +      G
Sbjct: 361 PFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG 420

Query: 416 -VLPSNEADIGLLAAPKPF 433
              PS+      L  P P+
Sbjct: 421 QPRPSHHGVFAFLVTPSPY 439


>DQ282153-1|ABB77901.1|  497|Homo sapiens cytochrome P450 2D6
           protein.
          Length = 497

 Score =  117 bits (281), Expect = 1e-25
 Identities = 63/199 (31%), Positives = 99/199 (49%), Gaps = 2/199 (1%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGD-SMPCWADSS 295
           ++ L  V  DL  AG  TT   + + LL ++ + ++Q ++  EI++ IG    P   D +
Sbjct: 292 DENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDMIGQVRRPEMGDQA 351

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
            + YT+A + EV R   I PL       +D  + G+ IPK TT++ +L+ +  D  +W  
Sbjct: 352 HMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEK 411

Query: 356 PHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNG 415
           P    PE F+D +G     E   PF +GRR C G+ LAR  +F+ F  +LQ +      G
Sbjct: 412 PFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG 471

Query: 416 -VLPSNEADIGLLAAPKPF 433
              PS+      L  P P+
Sbjct: 472 QPRPSHHGVFAFLVTPSPY 490



 Score = 60.1 bits (139), Expect = 2e-08
 Identities = 45/157 (28%), Positives = 68/157 (43%), Gaps = 5/157 (3%)

Query: 74  VLGLKLGRELVVVVYGEKNVRQVFSESEFD--GRPNSFFYKLRCLGKRLGVTFVD--GPL 129
           V  L+L    VVV+ G   VR+       D   RP     ++   G R    F+   GP 
Sbjct: 68  VFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPA 127

Query: 130 WREHRQFTVKHLKNVGFGKTSMELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLW 189
           WRE R+F++  L+N+G GK S+E  +  E   L     ++  +P + + +   AV NV+ 
Sbjct: 128 WREQRRFSISTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIA 187

Query: 190 KYVAGERIREDKLERLLELFYLRSKAFTLTGGLLSKI 226
               G R   D   R L L  L  +      G L ++
Sbjct: 188 SLTCGRRFEYDD-PRFLRLLDLAQEGLKEESGFLREV 223


>BC106758-1|AAI06759.1|  497|Homo sapiens cytochrome P450, family 2,
           subfamily D, polypeptide 6 protein.
          Length = 497

 Score =  117 bits (281), Expect = 1e-25
 Identities = 63/199 (31%), Positives = 98/199 (49%), Gaps = 2/199 (1%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGD-SMPCWADSS 295
           ++ L  V  DL  AG  TT   + + LL ++ + ++Q ++  EI+  IG    P   D +
Sbjct: 292 DENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDEVIGQVRRPEMGDQA 351

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
            + YT+A + EV R   I PL       +D  + G+ IPK TT++ +L+ +  D  +W  
Sbjct: 352 HMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEK 411

Query: 356 PHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNG 415
           P    PE F+D +G     E   PF +GRR C G+ LAR  +F+ F  +LQ +      G
Sbjct: 412 PFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG 471

Query: 416 -VLPSNEADIGLLAAPKPF 433
              PS+      L  P P+
Sbjct: 472 QPRPSHHGVFAFLVTPSPY 490



 Score = 60.5 bits (140), Expect = 1e-08
 Identities = 46/157 (29%), Positives = 68/157 (43%), Gaps = 5/157 (3%)

Query: 74  VLGLKLGRELVVVVYGEKNVRQVFSESEFD--GRPNSFFYKLRCLGKRLGVTFVD--GPL 129
           V  L+L    VVV+ G   VR+       D   RP     ++   G R    F+   GP 
Sbjct: 68  VFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPA 127

Query: 130 WREHRQFTVKHLKNVGFGKTSMELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLW 189
           WRE R+F+V  L+N+G GK S+E  +  E   L     ++  +P + + +   AV NV+ 
Sbjct: 128 WREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIA 187

Query: 190 KYVAGERIREDKLERLLELFYLRSKAFTLTGGLLSKI 226
               G R   D   R L L  L  +      G L ++
Sbjct: 188 SLTCGRRFEYDD-PRFLRLLDLAQEGLKEESGFLREV 223


>AF372573-1|AAL69652.1|  495|Homo sapiens cytochrome P450 2F1
           protein.
          Length = 495

 Score =  116 bits (280), Expect = 1e-25
 Identities = 63/199 (31%), Positives = 101/199 (50%), Gaps = 3/199 (1%)

Query: 238 DQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDS-MPCWADSSK 296
           D L     +L+  G++T    +  A L++++   +Q ++  EI+  +G + +P   D + 
Sbjct: 290 DTLLMTTHNLLFGGTKTVSTTLHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDRAA 349

Query: 297 LVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDP 356
           + YT A + EV R   I P+  P RV +DT   G++IPK T V+  L  +H DP+ +  P
Sbjct: 350 MPYTDAVIHEVQRFADIIPMNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTP 409

Query: 357 HEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGV 416
            E  PE F+D     K +    PF +GRR C G+SLAR  +F+    ILQ + +  +   
Sbjct: 410 QEFNPEHFLDANQSFKKSPAFMPFSAGRRLCLGESLARMELFLYLTAILQSFSLQPLGAP 469

Query: 417 --LPSNEADIGLLAAPKPF 433
             +       GL   P+PF
Sbjct: 470 EDIDLTPLSSGLGNLPRPF 488



 Score = 62.1 bits (144), Expect = 4e-09
 Identities = 48/161 (29%), Positives = 79/161 (49%), Gaps = 10/161 (6%)

Query: 62  ALLELSKQWSTQVLGLKLGRELVVVVYGEKNVRQVFSES--EFDGRPN--SFFYKLRCLG 117
           +L +LSK++ +    + LG   VVV+ G + V++   +   EF GR +  +FF       
Sbjct: 54  SLTKLSKEYGSMYT-VHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFN----FT 108

Query: 118 KRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTSMELEIQNELKLLREYINDNKHKPIKVD 177
           K  G+ F  G  W+  RQF+++ L+N G GK S+E  I  E   L   +   + +P    
Sbjct: 109 KGNGIAFSSGDRWKVLRQFSIQILRNFGMGKRSIEERILEEGSFLLAELRKTEGEPFDPT 168

Query: 178 SMFSSAVMNVLWKYVAGERIREDKLERLLELFYLRSKAFTL 218
            + S +V N++   + G R   D  ERLL +  L +  F +
Sbjct: 169 FVLSRSVSNIICSVLFGSRFDYDD-ERLLTIIRLINDNFQI 208


>X13897-1|CAA32097.1|  489|Homo sapiens protein ( Human mRNA for
           cytochrome P-450IIA. ).
          Length = 489

 Score =  116 bits (279), Expect = 2e-25
 Identities = 54/199 (27%), Positives = 106/199 (53%), Gaps = 3/199 (1%)

Query: 245 LDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDS-MPCWADSSKLVYTSAF 303
           L+L I G++T    +++  L ++++  ++ ++  EI+  IG +  P + D +K+ Y  A 
Sbjct: 291 LNLFIGGTETVSTTLRYGFLLLMKHPEVEAQVHEEIDRVIGKNRQPKFEDRAKMPYMEAV 350

Query: 304 LLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPER 363
           + E+ R   + P++  RRV +DT    + +PK T V   L  +  DP+ + +P +  P+ 
Sbjct: 351 IHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQH 410

Query: 364 FIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGV--LPSNE 421
           F++EKG  K ++   PF  G+R C G+ LAR  +F+ F  ++Q +R+        +  + 
Sbjct: 411 FLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSP 470

Query: 422 ADIGLLAAPKPFVANFVSR 440
             +G    P+ +  +F+ R
Sbjct: 471 KHVGFATIPRNYTMSFLPR 489



 Score = 58.8 bits (136), Expect = 4e-08
 Identities = 53/193 (27%), Positives = 88/193 (45%), Gaps = 11/193 (5%)

Query: 29  NQWFMAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVY 88
           N+  + PGP   PF G+   +Q  T +    + +L+++S+++   V  + LG   VVV+ 
Sbjct: 24  NKGKLPPGPTPLPFIGN--YLQLNTEQ---MYNSLMKISERYGP-VFTIHLGPRRVVVLC 77

Query: 89  GEKNVRQVFSES--EFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGF 146
           G   VR+   +   EF GR     +    + K  GV F +G   ++ R+F++  L++ G 
Sbjct: 78  GHDAVREALVDQAEEFSGRGEQATFDW--VFKGYGVVFSNGERAKQLRRFSIATLRDFGV 135

Query: 147 GKTSMELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERIREDKLERLL 206
           GK  +E  IQ E   L + +       I      S  V NV+   V G+R  + K +  L
Sbjct: 136 GKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRF-DYKDKEFL 194

Query: 207 ELFYLRSKAFTLT 219
            L  +    F  T
Sbjct: 195 SLLRMMLGIFQFT 207


>AY513608-1|AAR90939.1|  494|Homo sapiens cytochrome P450 2A13
           variant 5 protein.
          Length = 494

 Score =  116 bits (278), Expect = 2e-25
 Identities = 56/199 (28%), Positives = 103/199 (51%), Gaps = 3/199 (1%)

Query: 245 LDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDS-MPCWADSSKLVYTSAF 303
           L+L  AG++T    +++  L ++++  ++ K+  EI+  IG +  P + D +K+ YT A 
Sbjct: 296 LNLFFAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAV 355

Query: 304 LLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPER 363
           + E+ R   + P+    RV +DT    + +PK T V   L  +  DP  + +P +  P+ 
Sbjct: 356 IHEIQRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQH 415

Query: 364 FIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGV--LPSNE 421
           F+D+KG  K ++   PF  G+R C G+ LAR  +F+ F  I+Q +R         +  + 
Sbjct: 416 FLDKKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSP 475

Query: 422 ADIGLLAAPKPFVANFVSR 440
             +G    P+ +  +F+ R
Sbjct: 476 KHVGFATIPRNYTMSFLPR 494



 Score = 61.7 bits (143), Expect = 5e-09
 Identities = 57/190 (30%), Positives = 86/190 (45%), Gaps = 11/190 (5%)

Query: 33  MAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKN 92
           + PGP   PF G+   +Q  T +    + +L+++S+++   V  + LG   VVV+ G   
Sbjct: 33  LPPGPTPLPFIGN--YLQLNTEQ---MYNSLMKISERYGP-VFTIHLGPRRVVVLCGHDA 86

Query: 93  VRQVFSES--EFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTS 150
           V++   +   EF GR     +    L K  GV F +G   ++ R+F++  L+  G GK  
Sbjct: 87  VKEALVDQAEEFSGRGEQATFDW--LFKGYGVAFSNGERAKQLRRFSIATLRGFGVGKRG 144

Query: 151 MELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERI-REDKLERLLELF 209
           +E  IQ E   L E +       I      S  V NV+   V G+R   EDK    L   
Sbjct: 145 IEERIQEEAGFLIEALRGTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRM 204

Query: 210 YLRSKAFTLT 219
            L S  FT T
Sbjct: 205 MLGSFQFTAT 214


>AY513606-1|AAR90937.1|  494|Homo sapiens cytochrome P450 2A13
           variant 3 protein.
          Length = 494

 Score =  116 bits (278), Expect = 2e-25
 Identities = 56/199 (28%), Positives = 103/199 (51%), Gaps = 3/199 (1%)

Query: 245 LDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDS-MPCWADSSKLVYTSAF 303
           L+L  AG++T    +++  L ++++  ++ K+  EI+  IG +  P + D +K+ YT A 
Sbjct: 296 LNLFFAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAV 355

Query: 304 LLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPER 363
           + E+ R   + P+    RV +DT    + +PK T V   L  +  DP  + +P +  P+ 
Sbjct: 356 IHEIQRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQH 415

Query: 364 FIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGV--LPSNE 421
           F+D+KG  K ++   PF  G+R C G+ LAR  +F+ F  I+Q +R         +  + 
Sbjct: 416 FLDKKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSP 475

Query: 422 ADIGLLAAPKPFVANFVSR 440
             +G    P+ +  +F+ R
Sbjct: 476 KHVGFATIPRNYTMSFLPR 494



 Score = 60.5 bits (140), Expect = 1e-08
 Identities = 56/190 (29%), Positives = 86/190 (45%), Gaps = 11/190 (5%)

Query: 33  MAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKN 92
           + PGP   PF G+   +Q  T +    + +L+++S+++   V  + LG   VVV+ G   
Sbjct: 33  LPPGPTPLPFIGN--YLQLNTEQ---MYNSLMKISERYGP-VFTIHLGPRRVVVLCGHDA 86

Query: 93  VRQVFSES--EFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTS 150
           V++   +   EF GR     +    L K  GV F +G   ++ R+F++  L+  G GK  
Sbjct: 87  VKEALVDQAEEFSGRGEQATFDW--LFKGYGVAFSNGERAKQLRRFSIATLRGFGVGKRG 144

Query: 151 MELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERI-REDKLERLLELF 209
           +E  IQ E   L + +       I      S  V NV+   V G+R   EDK    L   
Sbjct: 145 IEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRM 204

Query: 210 YLRSKAFTLT 219
            L S  FT T
Sbjct: 205 MLGSFQFTAT 214


>AY513605-1|AAR90936.1|  494|Homo sapiens cytochrome P450 2A13
           variant 2 protein.
          Length = 494

 Score =  116 bits (278), Expect = 2e-25
 Identities = 56/199 (28%), Positives = 103/199 (51%), Gaps = 3/199 (1%)

Query: 245 LDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDS-MPCWADSSKLVYTSAF 303
           L+L  AG++T    +++  L ++++  ++ K+  EI+  IG +  P + D +K+ YT A 
Sbjct: 296 LNLFFAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAV 355

Query: 304 LLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPER 363
           + E+ R   + P+    RV +DT    + +PK T V   L  +  DP  + +P +  P+ 
Sbjct: 356 IHEIQRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQH 415

Query: 364 FIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGV--LPSNE 421
           F+D+KG  K ++   PF  G+R C G+ LAR  +F+ F  I+Q +R         +  + 
Sbjct: 416 FLDKKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSP 475

Query: 422 ADIGLLAAPKPFVANFVSR 440
             +G    P+ +  +F+ R
Sbjct: 476 KHVGFATIPRNYTMSFLPR 494



 Score = 60.5 bits (140), Expect = 1e-08
 Identities = 56/190 (29%), Positives = 86/190 (45%), Gaps = 11/190 (5%)

Query: 33  MAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKN 92
           + PGP   PF G+   +Q  T +    + +L+++S+++   V  + LG   VVV+ G   
Sbjct: 33  LPPGPTPLPFIGN--YLQLNTEQ---MYNSLMKISERYGP-VFTIHLGPRRVVVLCGHDA 86

Query: 93  VRQVFSES--EFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTS 150
           V++   +   EF GR     +    L K  GV F +G   ++ R+F++  L+  G GK  
Sbjct: 87  VKEALVDQAEEFSGRGEQATFDW--LFKGYGVAFSNGERAKQLRRFSIATLRGFGVGKRG 144

Query: 151 MELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERI-REDKLERLLELF 209
           +E  IQ E   L + +       I      S  V NV+   V G+R   EDK    L   
Sbjct: 145 IEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRM 204

Query: 210 YLRSKAFTLT 219
            L S  FT T
Sbjct: 205 MLGSFQFTAT 214


>AY513604-1|AAR90935.1|  494|Homo sapiens cytochrome P450 2A13
           variant 1 protein.
          Length = 494

 Score =  116 bits (278), Expect = 2e-25
 Identities = 56/199 (28%), Positives = 103/199 (51%), Gaps = 3/199 (1%)

Query: 245 LDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDS-MPCWADSSKLVYTSAF 303
           L+L  AG++T    +++  L ++++  ++ K+  EI+  IG +  P + D +K+ YT A 
Sbjct: 296 LNLFFAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAV 355

Query: 304 LLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPER 363
           + E+ R   + P+    RV +DT    + +PK T V   L  +  DP  + +P +  P+ 
Sbjct: 356 IHEIQRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQH 415

Query: 364 FIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGV--LPSNE 421
           F+D+KG  K ++   PF  G+R C G+ LAR  +F+ F  I+Q +R         +  + 
Sbjct: 416 FLDKKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSP 475

Query: 422 ADIGLLAAPKPFVANFVSR 440
             +G    P+ +  +F+ R
Sbjct: 476 KHVGFATIPRNYTMSFLPR 494



 Score = 60.5 bits (140), Expect = 1e-08
 Identities = 56/190 (29%), Positives = 86/190 (45%), Gaps = 11/190 (5%)

Query: 33  MAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKN 92
           + PGP   PF G+   +Q  T +    + +L+++S+++   V  + LG   VVV+ G   
Sbjct: 33  LPPGPTPLPFIGN--YLQLNTEQ---MYNSLMKISERYGP-VFTIHLGPRRVVVLCGHDA 86

Query: 93  VRQVFSES--EFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTS 150
           V++   +   EF GR     +    L K  GV F +G   ++ R+F++  L+  G GK  
Sbjct: 87  VKEALVDQAEEFSGRGEQATFDW--LFKGYGVAFSNGERAKQLRRFSIATLRGFGVGKRG 144

Query: 151 MELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERI-REDKLERLLELF 209
           +E  IQ E   L + +       I      S  V NV+   V G+R   EDK    L   
Sbjct: 145 IEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRM 204

Query: 210 YLRSKAFTLT 219
            L S  FT T
Sbjct: 205 MLGSFQFTAT 214


>AF209774-1|AAG35775.1|  494|Homo sapiens cytochrome P450 2A13
           protein.
          Length = 494

 Score =  116 bits (278), Expect = 2e-25
 Identities = 56/199 (28%), Positives = 103/199 (51%), Gaps = 3/199 (1%)

Query: 245 LDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDS-MPCWADSSKLVYTSAF 303
           L+L  AG++T    +++  L ++++  ++ K+  EI+  IG +  P + D +K+ YT A 
Sbjct: 296 LNLFFAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAV 355

Query: 304 LLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPER 363
           + E+ R   + P+    RV +DT    + +PK T V   L  +  DP  + +P +  P+ 
Sbjct: 356 IHEIQRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQH 415

Query: 364 FIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGV--LPSNE 421
           F+D+KG  K ++   PF  G+R C G+ LAR  +F+ F  I+Q +R         +  + 
Sbjct: 416 FLDKKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSP 475

Query: 422 ADIGLLAAPKPFVANFVSR 440
             +G    P+ +  +F+ R
Sbjct: 476 KHVGFATIPRNYTMSFLPR 494



 Score = 60.5 bits (140), Expect = 1e-08
 Identities = 56/190 (29%), Positives = 86/190 (45%), Gaps = 11/190 (5%)

Query: 33  MAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKN 92
           + PGP   PF G+   +Q  T +    + +L+++S+++   V  + LG   VVV+ G   
Sbjct: 33  LPPGPTPLPFIGN--YLQLNTEQ---MYNSLMKISERYGP-VFTIHLGPRRVVVLCGHDA 86

Query: 93  VRQVFSES--EFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTS 150
           V++   +   EF GR     +    L K  GV F +G   ++ R+F++  L+  G GK  
Sbjct: 87  VKEALVDQAEEFSGRGEQATFDW--LFKGYGVAFSNGERAKQLRRFSIATLRGFGVGKRG 144

Query: 151 MELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERI-REDKLERLLELF 209
           +E  IQ E   L + +       I      S  V NV+   V G+R   EDK    L   
Sbjct: 145 IEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRM 204

Query: 210 YLRSKAFTLT 219
            L S  FT T
Sbjct: 205 MLGSFQFTAT 214


>AY513609-1|AAR90940.1|  494|Homo sapiens cytochrome P450 2A13
           variant 6 protein.
          Length = 494

 Score =  115 bits (277), Expect = 3e-25
 Identities = 56/199 (28%), Positives = 103/199 (51%), Gaps = 3/199 (1%)

Query: 245 LDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDS-MPCWADSSKLVYTSAF 303
           L+L  AG++T    +++  L ++++  ++ K+  EI+  IG +  P + D +K+ YT A 
Sbjct: 296 LNLFFAGTETVSTTLRYGFLLLMKHPELEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAV 355

Query: 304 LLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPER 363
           + E+ R   + P+    RV +DT    + +PK T V   L  +  DP  + +P +  P+ 
Sbjct: 356 IHEIQRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQH 415

Query: 364 FIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGV--LPSNE 421
           F+D+KG  K ++   PF  G+R C G+ LAR  +F+ F  I+Q +R         +  + 
Sbjct: 416 FLDKKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSP 475

Query: 422 ADIGLLAAPKPFVANFVSR 440
             +G    P+ +  +F+ R
Sbjct: 476 KHVGFATIPRNYTMSFLPR 494



 Score = 60.5 bits (140), Expect = 1e-08
 Identities = 56/190 (29%), Positives = 86/190 (45%), Gaps = 11/190 (5%)

Query: 33  MAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKN 92
           + PGP   PF G+   +Q  T +    + +L+++S+++   V  + LG   VVV+ G   
Sbjct: 33  LPPGPTPLPFIGN--YLQLNTEQ---MYNSLMKISERYGP-VFTIHLGPRRVVVLCGHDA 86

Query: 93  VRQVFSES--EFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTS 150
           V++   +   EF GR     +    L K  GV F +G   ++ R+F++  L+  G GK  
Sbjct: 87  VKEALVDQAEEFSGRGEQATFDW--LFKGYGVAFSNGERAKQLRRFSIATLRGFGVGKRG 144

Query: 151 MELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERI-REDKLERLLELF 209
           +E  IQ E   L + +       I      S  V NV+   V G+R   EDK    L   
Sbjct: 145 IEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRM 204

Query: 210 YLRSKAFTLT 219
            L S  FT T
Sbjct: 205 MLGSFQFTAT 214


>AF182275-1|AAF13600.1|  494|Homo sapiens cytochrome P450-2A6
           protein.
          Length = 494

 Score =  115 bits (277), Expect = 3e-25
 Identities = 51/167 (30%), Positives = 95/167 (56%), Gaps = 1/167 (0%)

Query: 245 LDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDS-MPCWADSSKLVYTSAF 303
           L+L I G++T    +++  L ++++  ++ K+  EI+  IG +  P + D +K+ Y  A 
Sbjct: 296 LNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAV 355

Query: 304 LLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPER 363
           + E+ R   + P++  RRV +DT    + +PK T V   L  +  DP+ + +P +  P+ 
Sbjct: 356 IHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQH 415

Query: 364 FIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRI 410
           F++EKG  K ++   PF  G+R C G+ LAR  +F+ F  ++Q +R+
Sbjct: 416 FLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRL 462



 Score = 58.0 bits (134), Expect = 6e-08
 Identities = 52/189 (27%), Positives = 86/189 (45%), Gaps = 11/189 (5%)

Query: 33  MAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKN 92
           + PGP   PF G+   +Q  T +    + +L+++S+++   V  + LG   VVV+ G   
Sbjct: 33  LPPGPTPLPFIGN--YLQLNTEQ---MYNSLMKISERYGP-VFTIHLGPRRVVVLCGHDA 86

Query: 93  VRQVFSES--EFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTS 150
           VR+   +   EF GR     +    + K  GV F +G   ++ R+F++  L++ G GK  
Sbjct: 87  VREALVDQAEEFSGRGEQATFDW--VFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRG 144

Query: 151 MELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERIREDKLERLLELFY 210
           +E  IQ E   L + +       I      S  V NV+   V G+R  + K +  L L  
Sbjct: 145 IEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRF-DYKDKEFLSLLR 203

Query: 211 LRSKAFTLT 219
           +    F  T
Sbjct: 204 MMLGIFQFT 212


>M21550-1|AAA52063.1|  495|Homo sapiens CYP21 protein.
          Length = 495

 Score =  115 bits (276), Expect = 4e-25
 Identities = 62/188 (32%), Positives = 103/188 (54%), Gaps = 8/188 (4%)

Query: 236 LNDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG----DSMPCW 291
           L   L    +DL+I G++TT N + +A++ +L +  IQ+++  E+++ +G     S   +
Sbjct: 278 LEGHLHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPY 337

Query: 292 ADSSKLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPN 351
            D ++L   +A + EV+R+  + PLA P R  + + I GY IP+ T ++ +L   HLD  
Sbjct: 338 KDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDET 397

Query: 352 LWPDPHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRID 411
           +W  PHE  P+RF+ E G    N     FG G R C G+ LAR  +F++   +LQ + + 
Sbjct: 398 VWERPHEFWPDRFL-EPG---KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLL 453

Query: 412 CVNGVLPS 419
                LPS
Sbjct: 454 PSGDALPS 461


>X58906-1|CAA41709.1|  495|Homo sapiens steroid 21-monooxygenase
           protein.
          Length = 495

 Score =  114 bits (275), Expect = 5e-25
 Identities = 61/188 (32%), Positives = 103/188 (54%), Gaps = 8/188 (4%)

Query: 236 LNDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG----DSMPCW 291
           L   +    +DL+I G++TT N + +A++ +L +  IQ+++  E+++ +G     S   +
Sbjct: 278 LEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPY 337

Query: 292 ADSSKLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPN 351
            D ++L   +A + EV+R+  + PLA P R  + + I GY IP+ T ++ +L   HLD  
Sbjct: 338 KDHARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDET 397

Query: 352 LWPDPHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRID 411
           +W  PHE  P+RF+ E G    N     FG G R C G+ LAR  +F++   +LQ + + 
Sbjct: 398 VWERPHEFWPDRFL-EPG---KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLL 453

Query: 412 CVNGVLPS 419
                LPS
Sbjct: 454 SSGDALPS 461


>U22028-1|AAB40519.1|  494|Homo sapiens cytochrome P450 protein.
          Length = 494

 Score =  114 bits (275), Expect = 5e-25
 Identities = 57/199 (28%), Positives = 102/199 (51%), Gaps = 3/199 (1%)

Query: 245 LDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDS-MPCWADSSKLVYTSAF 303
           L+L  AG++T    +++  L ++++  ++ K+  EI+  IG +  P + D +K+ YT A 
Sbjct: 296 LNLFFAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAV 355

Query: 304 LLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPER 363
           + E+ R   + P+    RV +DT    + +PK T V   L     DP  + +P +  P+ 
Sbjct: 356 IHEIQRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSELRDPRFFSNPQDCSPQH 415

Query: 364 FIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGV--LPSNE 421
           F+DEKG  K ++   PF  G+R C G+ LAR  +F+ F  I+Q +R         +  + 
Sbjct: 416 FLDEKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSP 475

Query: 422 ADIGLLAAPKPFVANFVSR 440
             +G    P+ +  +F+ R
Sbjct: 476 KHVGFATIPRNYTMSFLPR 494



 Score = 60.5 bits (140), Expect = 1e-08
 Identities = 55/191 (28%), Positives = 86/191 (45%), Gaps = 13/191 (6%)

Query: 33  MAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKN 92
           + PGP   PF G+   +Q  T +    + +L+++S+++   V  + LG   VVV+ G   
Sbjct: 33  LPPGPTPLPFIGN--YLQLNTEQ---MYNSLMKISERYGP-VFTIHLGPRRVVVLCGHDA 86

Query: 93  VRQVFSES--EFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTS 150
           V++   +   EF GR     +    L K  GV F +G   ++ R+F++  L+  G GK  
Sbjct: 87  VKEALVDQAEEFSGRGEQATFDW--LFKGYGVAFSNGERAKQLRRFSIATLRGFGVGKRG 144

Query: 151 MELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERI-REDKLERLLELF 209
           +E  IQ E   L + +       I      S  V NV+   V G+R   EDK    L L 
Sbjct: 145 IEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDK--EFLSLL 202

Query: 210 YLRSKAFTLTG 220
            +    F  TG
Sbjct: 203 RMMLGRFQFTG 213


>J02906-1|AAA52156.1|  491|Homo sapiens CYP2F1 protein.
          Length = 491

 Score =  114 bits (274), Expect = 7e-25
 Identities = 62/199 (31%), Positives = 100/199 (50%), Gaps = 3/199 (1%)

Query: 238 DQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDS-MPCWADSSK 296
           D L     +L+  G++T    +  A L++++   +Q ++  EI+  +G + +P   D + 
Sbjct: 286 DTLLMTTHNLLFGGTKTVSTTLHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDRAA 345

Query: 297 LVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDP 356
           + YT A + EV R   I P+  P RV +DT   G++IPK T V+  L  +H DP+ +  P
Sbjct: 346 MPYTDAVIHEVQRFADIIPMNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTP 405

Query: 357 HEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGV 416
            E  PE F+D     K +    PF +GRR C G+ LAR  +F+    ILQ + +  +   
Sbjct: 406 QEFNPEHFLDANQSFKKSPAFMPFSAGRRLCLGELLARMELFLYLTAILQSFSLQPLGAP 465

Query: 417 --LPSNEADIGLLAAPKPF 433
             +       GL   P+PF
Sbjct: 466 EDIDLTPLSSGLGNLPRPF 484



 Score = 62.1 bits (144), Expect = 4e-09
 Identities = 48/161 (29%), Positives = 79/161 (49%), Gaps = 10/161 (6%)

Query: 62  ALLELSKQWSTQVLGLKLGRELVVVVYGEKNVRQVFSES--EFDGRPN--SFFYKLRCLG 117
           +L +LSK++ +    + LG   VVV+ G + V++   +   EF GR +  +FF       
Sbjct: 54  SLTKLSKEYGSMYT-VHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFN----FT 108

Query: 118 KRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTSMELEIQNELKLLREYINDNKHKPIKVD 177
           K  G+ F  G  W+  RQF+++ L+N G GK S+E  I  E   L   +   + +P    
Sbjct: 109 KGNGIAFSSGDRWKVLRQFSIQILRNFGMGKRSIEERILEEGSFLLADVRKTEGEPFDPT 168

Query: 178 SMFSSAVMNVLWKYVAGERIREDKLERLLELFYLRSKAFTL 218
            + S +V N++   + G R   D  ERLL +  L +  F +
Sbjct: 169 FVLSRSVSNIICSVLFGSRFDYDD-ERLLTIIRLINDNFQI 208


>BC033691-1|AAH33691.1|  504|Homo sapiens cytochrome P450, family 2,
           subfamily S, polypeptide 1 protein.
          Length = 504

 Score =  114 bits (274), Expect = 7e-25
 Identities = 61/200 (30%), Positives = 100/200 (50%), Gaps = 3/200 (1%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSM-PCWADSS 295
           N  +    + L+ AG+ T    V + LL +++  ++Q+ +  E+   +G    P   D +
Sbjct: 289 NKNMLMTVIYLLFAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRT 348

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
           +L YT A L E  R+  + P+  PR +++ T   GY +P+ T V   L  I  DPN++  
Sbjct: 349 RLPYTDAVLHEAQRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKH 408

Query: 356 PHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRID--CV 413
           P E  P+RF+D  G  + +E   PF  G+R C G+ LA++ +F+ F  ILQ + ++  C 
Sbjct: 409 PEEFNPDRFLDADGRFRKHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCP 468

Query: 414 NGVLPSNEADIGLLAAPKPF 433
              L       GL   P  F
Sbjct: 469 PDTLSLKPTVSGLFNIPPAF 488



 Score = 60.9 bits (141), Expect = 9e-09
 Identities = 52/173 (30%), Positives = 81/173 (46%), Gaps = 12/173 (6%)

Query: 33  MAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGR-ELVVVVYGEK 91
           + PGP   P  G+      +  + G+ +  L+ LSK++   V  + LG    VVV+ G++
Sbjct: 32  LPPGPTPLPLLGNL-----LQLRPGALYSGLMRLSKKYGP-VFTIYLGPWRPVVVLVGQE 85

Query: 92  NVRQVFS--ESEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKT 149
            VR+       EF GR      +    G   GV F +G  WR+ R+FT+  L+++G GK 
Sbjct: 86  AVREALGGQAEEFSGRGTVAMLEGTFDGH--GVFFSNGERWRQLRKFTMLALRDLGMGKR 143

Query: 150 SMELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERIR-EDK 201
             E  IQ E + L E     + +P     + + A  NV+   + G R   EDK
Sbjct: 144 EGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSNVVCSLLFGLRFSYEDK 196


>AY358603-1|AAQ88966.1|  504|Homo sapiens Cytochrome p450 protein.
          Length = 504

 Score =  114 bits (274), Expect = 7e-25
 Identities = 61/200 (30%), Positives = 100/200 (50%), Gaps = 3/200 (1%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSM-PCWADSS 295
           N  +    + L+ AG+ T    V + LL +++  ++Q+ +  E+   +G    P   D +
Sbjct: 289 NKNMLMTVIYLLFAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRT 348

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
           +L YT A L E  R+  + P+  PR +++ T   GY +P+ T V   L  I  DPN++  
Sbjct: 349 RLPYTDAVLHEAQRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKH 408

Query: 356 PHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRID--CV 413
           P E  P+RF+D  G  + +E   PF  G+R C G+ LA++ +F+ F  ILQ + ++  C 
Sbjct: 409 PEEFNPDRFLDADGRFRKHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCP 468

Query: 414 NGVLPSNEADIGLLAAPKPF 433
              L       GL   P  F
Sbjct: 469 PDTLSLKPTVSGLFNIPPAF 488



 Score = 60.9 bits (141), Expect = 9e-09
 Identities = 52/173 (30%), Positives = 81/173 (46%), Gaps = 12/173 (6%)

Query: 33  MAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGR-ELVVVVYGEK 91
           + PGP   P  G+      +  + G+ +  L+ LSK++   V  + LG    VVV+ G++
Sbjct: 32  LPPGPTPLPLLGNL-----LQLRPGALYSGLMRLSKKYGP-VFTIYLGPWRPVVVLVGQE 85

Query: 92  NVRQVFS--ESEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKT 149
            VR+       EF GR      +    G   GV F +G  WR+ R+FT+  L+++G GK 
Sbjct: 86  AVREALGGQAEEFSGRGTVAMLEGTFDGH--GVFFSNGERWRQLRKFTMLALRDLGMGKR 143

Query: 150 SMELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERIR-EDK 201
             E  IQ E + L E     + +P     + + A  NV+   + G R   EDK
Sbjct: 144 EGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSNVVCSLLFGLRFSYEDK 196


>AF335278-1|AAK13498.1|  504|Homo sapiens cytochrome P450 2S1
           protein.
          Length = 504

 Score =  114 bits (274), Expect = 7e-25
 Identities = 61/200 (30%), Positives = 100/200 (50%), Gaps = 3/200 (1%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSM-PCWADSS 295
           N  +    + L+ AG+ T    V + LL +++  ++Q+ +  E+   +G    P   D +
Sbjct: 289 NKNMLMTVIYLLFAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRT 348

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
           +L YT A L E  R+  + P+  PR +++ T   GY +P+ T V   L  I  DPN++  
Sbjct: 349 RLPYTDAVLHEAQRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKH 408

Query: 356 PHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRID--CV 413
           P E  P+RF+D  G  + +E   PF  G+R C G+ LA++ +F+ F  ILQ + ++  C 
Sbjct: 409 PEEFNPDRFLDADGRFRKHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCP 468

Query: 414 NGVLPSNEADIGLLAAPKPF 433
              L       GL   P  F
Sbjct: 469 PDTLSLKPTVSGLFNIPPAF 488



 Score = 60.9 bits (141), Expect = 9e-09
 Identities = 52/173 (30%), Positives = 81/173 (46%), Gaps = 12/173 (6%)

Query: 33  MAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGR-ELVVVVYGEK 91
           + PGP   P  G+      +  + G+ +  L+ LSK++   V  + LG    VVV+ G++
Sbjct: 32  LPPGPTPLPLLGNL-----LQLRPGALYSGLMRLSKKYGP-VFTIYLGPWRPVVVLVGQE 85

Query: 92  NVRQVFS--ESEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKT 149
            VR+       EF GR      +    G   GV F +G  WR+ R+FT+  L+++G GK 
Sbjct: 86  AVREALGGQAEEFSGRGTVAMLEGTFDGH--GVFFSNGERWRQLRKFTMLALRDLGMGKR 143

Query: 150 SMELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERIR-EDK 201
             E  IQ E + L E     + +P     + + A  NV+   + G R   EDK
Sbjct: 144 EGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSNVVCSLLFGLRFSYEDK 196


>M28548-1|AAA52065.1|  495|Homo sapiens protein ( Human mutant
           21-hydroxylase B gene, complete cds. ).
          Length = 495

 Score =  113 bits (273), Expect = 9e-25
 Identities = 61/188 (32%), Positives = 103/188 (54%), Gaps = 8/188 (4%)

Query: 236 LNDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG----DSMPCW 291
           L   +    +DL+I G++TT N + +A++ +L +  IQ+++  E+++ +G     S   +
Sbjct: 278 LEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPY 337

Query: 292 ADSSKLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPN 351
            D ++L   +A + EV+R+  + PLA P R  + + I GY IP+ T ++ +L   HLD  
Sbjct: 338 KDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDET 397

Query: 352 LWPDPHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRID 411
           +W  PHE  P+RF+ E G    N     FG G R C G+ LAR  +F++   +LQ + + 
Sbjct: 398 VWERPHEFWPDRFL-EPG---KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLL 453

Query: 412 CVNGVLPS 419
                LPS
Sbjct: 454 PSGDALPS 461


>M26856-1|AAA52064.1|  495|Homo sapiens protein ( Human
           21-hydroxylase B gene, complete cds. ).
          Length = 495

 Score =  113 bits (273), Expect = 9e-25
 Identities = 61/188 (32%), Positives = 103/188 (54%), Gaps = 8/188 (4%)

Query: 236 LNDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG----DSMPCW 291
           L   +    +DL+I G++TT N + +A++ +L +  IQ+++  E+++ +G     S   +
Sbjct: 278 LEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPY 337

Query: 292 ADSSKLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPN 351
            D ++L   +A + EV+R+  + PLA P R  + + I GY IP+ T ++ +L   HLD  
Sbjct: 338 KDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDET 397

Query: 352 LWPDPHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRID 411
           +W  PHE  P+RF+ E G    N     FG G R C G+ LAR  +F++   +LQ + + 
Sbjct: 398 VWERPHEFWPDRFL-EPG---KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLL 453

Query: 412 CVNGVLPS 419
                LPS
Sbjct: 454 PSGDALPS 461


>M13936-1|AAA59695.1|  494|Homo sapiens CYP21P protein.
          Length = 494

 Score =  113 bits (273), Expect = 9e-25
 Identities = 61/188 (32%), Positives = 103/188 (54%), Gaps = 8/188 (4%)

Query: 236 LNDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG----DSMPCW 291
           L   +    +DL+I G++TT N + +A++ +L +  IQ+++  E+++ +G     S   +
Sbjct: 277 LEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPY 336

Query: 292 ADSSKLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPN 351
            D ++L   +A + EV+R+  + PLA P R  + + I GY IP+ T ++ +L   HLD  
Sbjct: 337 KDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDET 396

Query: 352 LWPDPHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRID 411
           +W  PHE  P+RF+ E G    N     FG G R C G+ LAR  +F++   +LQ + + 
Sbjct: 397 VWERPHEFWPDRFL-EPG---KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLL 452

Query: 412 CVNGVLPS 419
                LPS
Sbjct: 453 PSGDALPS 460


>BX679671-8|CAM26071.1|  464|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 464

 Score =  113 bits (273), Expect = 9e-25
 Identities = 61/188 (32%), Positives = 103/188 (54%), Gaps = 8/188 (4%)

Query: 236 LNDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG----DSMPCW 291
           L   +    +DL+I G++TT N + +A++ +L +  IQ+++  E+++ +G     S   +
Sbjct: 247 LEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPY 306

Query: 292 ADSSKLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPN 351
            D ++L   +A + EV+R+  + PLA P R  + + I GY IP+ T ++ +L   HLD  
Sbjct: 307 KDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDET 366

Query: 352 LWPDPHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRID 411
           +W  PHE  P+RF+ E G    N     FG G R C G+ LAR  +F++   +LQ + + 
Sbjct: 367 VWERPHEFWPDRFL-EPG---KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLL 422

Query: 412 CVNGVLPS 419
                LPS
Sbjct: 423 PSGDALPS 430


>BX679671-7|CAM26070.1|  494|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 494

 Score =  113 bits (273), Expect = 9e-25
 Identities = 61/188 (32%), Positives = 103/188 (54%), Gaps = 8/188 (4%)

Query: 236 LNDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG----DSMPCW 291
           L   +    +DL+I G++TT N + +A++ +L +  IQ+++  E+++ +G     S   +
Sbjct: 277 LEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPY 336

Query: 292 ADSSKLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPN 351
            D ++L   +A + EV+R+  + PLA P R  + + I GY IP+ T ++ +L   HLD  
Sbjct: 337 KDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDET 396

Query: 352 LWPDPHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRID 411
           +W  PHE  P+RF+ E G    N     FG G R C G+ LAR  +F++   +LQ + + 
Sbjct: 397 VWERPHEFWPDRFL-EPG---KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLL 452

Query: 412 CVNGVLPS 419
                LPS
Sbjct: 453 PSGDALPS 460


>BC125182-1|AAI25183.1|  494|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 494

 Score =  113 bits (273), Expect = 9e-25
 Identities = 61/188 (32%), Positives = 103/188 (54%), Gaps = 8/188 (4%)

Query: 236 LNDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG----DSMPCW 291
           L   +    +DL+I G++TT N + +A++ +L +  IQ+++  E+++ +G     S   +
Sbjct: 277 LEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPY 336

Query: 292 ADSSKLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPN 351
            D ++L   +A + EV+R+  + PLA P R  + + I GY IP+ T ++ +L   HLD  
Sbjct: 337 KDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDET 396

Query: 352 LWPDPHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRID 411
           +W  PHE  P+RF+ E G    N     FG G R C G+ LAR  +F++   +LQ + + 
Sbjct: 397 VWERPHEFWPDRFL-EPG---KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLL 452

Query: 412 CVNGVLPS 419
                LPS
Sbjct: 453 PSGDALPS 460


>BC125181-1|AAI25182.1|  495|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 495

 Score =  113 bits (273), Expect = 9e-25
 Identities = 61/188 (32%), Positives = 103/188 (54%), Gaps = 8/188 (4%)

Query: 236 LNDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG----DSMPCW 291
           L   +    +DL+I G++TT N + +A++ +L +  IQ+++  E+++ +G     S   +
Sbjct: 278 LEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPY 337

Query: 292 ADSSKLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPN 351
            D ++L   +A + EV+R+  + PLA P R  + + I GY IP+ T ++ +L   HLD  
Sbjct: 338 KDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDET 397

Query: 352 LWPDPHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRID 411
           +W  PHE  P+RF+ E G    N     FG G R C G+ LAR  +F++   +LQ + + 
Sbjct: 398 VWERPHEFWPDRFL-EPG---KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLL 453

Query: 412 CVNGVLPS 419
                LPS
Sbjct: 454 PSGDALPS 461


>AM183951-1|CAJ75805.1|  494|Homo sapiens steroid 21-hydroxylase,
           CYP21 protein.
          Length = 494

 Score =  113 bits (273), Expect = 9e-25
 Identities = 61/188 (32%), Positives = 103/188 (54%), Gaps = 8/188 (4%)

Query: 236 LNDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG----DSMPCW 291
           L   +    +DL+I G++TT N + +A++ +L +  IQ+++  E+++ +G     S   +
Sbjct: 277 LEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPY 336

Query: 292 ADSSKLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPN 351
            D ++L   +A + EV+R+  + PLA P R  + + I GY IP+ T ++ +L   HLD  
Sbjct: 337 KDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDET 396

Query: 352 LWPDPHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRID 411
           +W  PHE  P+RF+ E G    N     FG G R C G+ LAR  +F++   +LQ + + 
Sbjct: 397 VWERPHEFWPDRFL-EPG---KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLL 452

Query: 412 CVNGVLPS 419
                LPS
Sbjct: 453 PSGDALPS 460


>AM183947-1|CAJ75801.1|  494|Homo sapiens steroid 21-hydroxylase,
           CYP21 protein.
          Length = 494

 Score =  113 bits (273), Expect = 9e-25
 Identities = 61/188 (32%), Positives = 103/188 (54%), Gaps = 8/188 (4%)

Query: 236 LNDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG----DSMPCW 291
           L   +    +DL+I G++TT N + +A++ +L +  IQ+++  E+++ +G     S   +
Sbjct: 277 LEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPY 336

Query: 292 ADSSKLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPN 351
            D ++L   +A + EV+R+  + PLA P R  + + I GY IP+ T ++ +L   HLD  
Sbjct: 337 KDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDET 396

Query: 352 LWPDPHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRID 411
           +W  PHE  P+RF+ E G    N     FG G R C G+ LAR  +F++   +LQ + + 
Sbjct: 397 VWERPHEFWPDRFL-EPG---KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLL 452

Query: 412 CVNGVLPS 419
                LPS
Sbjct: 453 PSGDALPS 460


>AM183946-1|CAJ75800.1|  494|Homo sapiens steroid 21-hydroxylase,
           CYP21 protein.
          Length = 494

 Score =  113 bits (273), Expect = 9e-25
 Identities = 61/188 (32%), Positives = 103/188 (54%), Gaps = 8/188 (4%)

Query: 236 LNDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG----DSMPCW 291
           L   +    +DL+I G++TT N + +A++ +L +  IQ+++  E+++ +G     S   +
Sbjct: 277 LEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPY 336

Query: 292 ADSSKLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPN 351
            D ++L   +A + EV+R+  + PLA P R  + + I GY IP+ T ++ +L   HLD  
Sbjct: 337 KDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDET 396

Query: 352 LWPDPHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRID 411
           +W  PHE  P+RF+ E G    N     FG G R C G+ LAR  +F++   +LQ + + 
Sbjct: 397 VWERPHEFWPDRFL-EPG---KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLL 452

Query: 412 CVNGVLPS 419
                LPS
Sbjct: 453 PSGDALPS 460


>AM183945-1|CAJ75799.1|  494|Homo sapiens steroid 21-hydroxylase,
           CYP21 protein.
          Length = 494

 Score =  113 bits (273), Expect = 9e-25
 Identities = 61/188 (32%), Positives = 103/188 (54%), Gaps = 8/188 (4%)

Query: 236 LNDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG----DSMPCW 291
           L   +    +DL+I G++TT N + +A++ +L +  IQ+++  E+++ +G     S   +
Sbjct: 277 LEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPY 336

Query: 292 ADSSKLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPN 351
            D ++L   +A + EV+R+  + PLA P R  + + I GY IP+ T ++ +L   HLD  
Sbjct: 337 KDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDET 396

Query: 352 LWPDPHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRID 411
           +W  PHE  P+RF+ E G    N     FG G R C G+ LAR  +F++   +LQ + + 
Sbjct: 397 VWERPHEFWPDRFL-EPG---KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLL 452

Query: 412 CVNGVLPS 419
                LPS
Sbjct: 453 PSGDALPS 460


>AM086565-1|CAJ31104.1|  494|Homo sapiens steroid 21-hydroxylase,
           CYP21 protein.
          Length = 494

 Score =  113 bits (273), Expect = 9e-25
 Identities = 61/188 (32%), Positives = 103/188 (54%), Gaps = 8/188 (4%)

Query: 236 LNDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG----DSMPCW 291
           L   +    +DL+I G++TT N + +A++ +L +  IQ+++  E+++ +G     S   +
Sbjct: 277 LEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPY 336

Query: 292 ADSSKLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPN 351
            D ++L   +A + EV+R+  + PLA P R  + + I GY IP+ T ++ +L   HLD  
Sbjct: 337 KDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGTHLDET 396

Query: 352 LWPDPHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRID 411
           +W  PHE  P+RF+ E G    N     FG G R C G+ LAR  +F++   +LQ + + 
Sbjct: 397 VWERPHEFWPDRFL-EPG---KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLL 452

Query: 412 CVNGVLPS 419
                LPS
Sbjct: 453 PSGDALPS 460


>AM086564-1|CAJ31103.1|  494|Homo sapiens steroid 21-hydroxylase,
           CYP21 protein.
          Length = 494

 Score =  113 bits (273), Expect = 9e-25
 Identities = 61/188 (32%), Positives = 103/188 (54%), Gaps = 8/188 (4%)

Query: 236 LNDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG----DSMPCW 291
           L   +    +DL+I G++TT N + +A++ +L +  IQ+++  E+++ +G     S   +
Sbjct: 277 LEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPY 336

Query: 292 ADSSKLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPN 351
            D ++L   +A + EV+R+  + PLA P R  + + I GY IP+ T ++ +L   HLD  
Sbjct: 337 KDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDET 396

Query: 352 LWPDPHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRID 411
           +W  PHE  P+RF+ E G    N     FG G R C G+ LAR  +F++   +LQ + + 
Sbjct: 397 VWERPHEFWPDRFL-EPG---KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLL 452

Query: 412 CVNGVLPS 419
                LPS
Sbjct: 453 PSGDALPS 460


>AL929593-2|CAI41778.1|  465|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 465

 Score =  113 bits (273), Expect = 9e-25
 Identities = 61/188 (32%), Positives = 103/188 (54%), Gaps = 8/188 (4%)

Query: 236 LNDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG----DSMPCW 291
           L   +    +DL+I G++TT N + +A++ +L +  IQ+++  E+++ +G     S   +
Sbjct: 248 LEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPY 307

Query: 292 ADSSKLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPN 351
            D ++L   +A + EV+R+  + PLA P R  + + I GY IP+ T ++ +L   HLD  
Sbjct: 308 KDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDET 367

Query: 352 LWPDPHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRID 411
           +W  PHE  P+RF+ E G    N     FG G R C G+ LAR  +F++   +LQ + + 
Sbjct: 368 VWERPHEFWPDRFL-EPG---KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLL 423

Query: 412 CVNGVLPS 419
                LPS
Sbjct: 424 PSGDALPS 431


>AL929593-1|CAI41779.1|  495|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 495

 Score =  113 bits (273), Expect = 9e-25
 Identities = 61/188 (32%), Positives = 103/188 (54%), Gaps = 8/188 (4%)

Query: 236 LNDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG----DSMPCW 291
           L   +    +DL+I G++TT N + +A++ +L +  IQ+++  E+++ +G     S   +
Sbjct: 278 LEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPY 337

Query: 292 ADSSKLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPN 351
            D ++L   +A + EV+R+  + PLA P R  + + I GY IP+ T ++ +L   HLD  
Sbjct: 338 KDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDET 397

Query: 352 LWPDPHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRID 411
           +W  PHE  P+RF+ E G    N     FG G R C G+ LAR  +F++   +LQ + + 
Sbjct: 398 VWERPHEFWPDRFL-EPG---KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLL 453

Query: 412 CVNGVLPS 419
                LPS
Sbjct: 454 PSGDALPS 461


>AL662849-19|CAI17480.1|  465|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 465

 Score =  113 bits (273), Expect = 9e-25
 Identities = 61/188 (32%), Positives = 103/188 (54%), Gaps = 8/188 (4%)

Query: 236 LNDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG----DSMPCW 291
           L   +    +DL+I G++TT N + +A++ +L +  IQ+++  E+++ +G     S   +
Sbjct: 248 LEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPY 307

Query: 292 ADSSKLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPN 351
            D ++L   +A + EV+R+  + PLA P R  + + I GY IP+ T ++ +L   HLD  
Sbjct: 308 KDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDET 367

Query: 352 LWPDPHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRID 411
           +W  PHE  P+RF+ E G    N     FG G R C G+ LAR  +F++   +LQ + + 
Sbjct: 368 VWERPHEFWPDRFL-EPG---KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLL 423

Query: 412 CVNGVLPS 419
                LPS
Sbjct: 424 PSGDALPS 431


>AL662849-18|CAI17479.1|  495|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 495

 Score =  113 bits (273), Expect = 9e-25
 Identities = 61/188 (32%), Positives = 103/188 (54%), Gaps = 8/188 (4%)

Query: 236 LNDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG----DSMPCW 291
           L   +    +DL+I G++TT N + +A++ +L +  IQ+++  E+++ +G     S   +
Sbjct: 278 LEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPY 337

Query: 292 ADSSKLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPN 351
            D ++L   +A + EV+R+  + PLA P R  + + I GY IP+ T ++ +L   HLD  
Sbjct: 338 KDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDET 397

Query: 352 LWPDPHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRID 411
           +W  PHE  P+RF+ E G    N     FG G R C G+ LAR  +F++   +LQ + + 
Sbjct: 398 VWERPHEFWPDRFL-EPG---KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLL 453

Query: 412 CVNGVLPS 419
                LPS
Sbjct: 454 PSGDALPS 461


>AL645922-24|CAI41754.1|  495|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 495

 Score =  113 bits (273), Expect = 9e-25
 Identities = 61/188 (32%), Positives = 103/188 (54%), Gaps = 8/188 (4%)

Query: 236 LNDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG----DSMPCW 291
           L   +    +DL+I G++TT N + +A++ +L +  IQ+++  E+++ +G     S   +
Sbjct: 278 LEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPY 337

Query: 292 ADSSKLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPN 351
            D ++L   +A + EV+R+  + PLA P R  + + I GY IP+ T ++ +L   HLD  
Sbjct: 338 KDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDET 397

Query: 352 LWPDPHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRID 411
           +W  PHE  P+RF+ E G    N     FG G R C G+ LAR  +F++   +LQ + + 
Sbjct: 398 VWERPHEFWPDRFL-EPG---KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLL 453

Query: 412 CVNGVLPS 419
                LPS
Sbjct: 454 PSGDALPS 461


>AL645922-23|CAI41755.1|  465|Homo sapiens cytochrome P450, family
           21, subfamily A, polypeptide 2 protein.
          Length = 465

 Score =  113 bits (273), Expect = 9e-25
 Identities = 61/188 (32%), Positives = 103/188 (54%), Gaps = 8/188 (4%)

Query: 236 LNDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG----DSMPCW 291
           L   +    +DL+I G++TT N + +A++ +L +  IQ+++  E+++ +G     S   +
Sbjct: 248 LEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPY 307

Query: 292 ADSSKLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPN 351
            D ++L   +A + EV+R+  + PLA P R  + + I GY IP+ T ++ +L   HLD  
Sbjct: 308 KDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDET 367

Query: 352 LWPDPHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRID 411
           +W  PHE  P+RF+ E G    N     FG G R C G+ LAR  +F++   +LQ + + 
Sbjct: 368 VWERPHEFWPDRFL-EPG---KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLL 423

Query: 412 CVNGVLPS 419
                LPS
Sbjct: 424 PSGDALPS 431


>AL049547-7|CAB89301.1|  495|Homo sapiens dJ34F7.3 (cytochrome P450,
           subfamily XXIA (steroid 21-hydroxylase, congenital a
           protein.
          Length = 495

 Score =  113 bits (273), Expect = 9e-25
 Identities = 61/188 (32%), Positives = 103/188 (54%), Gaps = 8/188 (4%)

Query: 236 LNDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG----DSMPCW 291
           L   +    +DL+I G++TT N + +A++ +L +  IQ+++  E+++ +G     S   +
Sbjct: 278 LEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPY 337

Query: 292 ADSSKLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPN 351
            D ++L   +A + EV+R+  + PLA P R  + + I GY IP+ T ++ +L   HLD  
Sbjct: 338 KDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDET 397

Query: 352 LWPDPHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRID 411
           +W  PHE  P+RF+ E G    N     FG G R C G+ LAR  +F++   +LQ + + 
Sbjct: 398 VWERPHEFWPDRFL-EPG---KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLL 453

Query: 412 CVNGVLPS 419
                LPS
Sbjct: 454 PSGDALPS 461


>AF077974-1|AAD45405.1|  403|Homo sapiens cytochrome P450
           21-hydroxylase protein.
          Length = 403

 Score =  113 bits (273), Expect = 9e-25
 Identities = 61/188 (32%), Positives = 103/188 (54%), Gaps = 8/188 (4%)

Query: 236 LNDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG----DSMPCW 291
           L   +    +DL+I G++TT N + +A++ +L +  IQ+++  E+++ +G     S   +
Sbjct: 186 LEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPY 245

Query: 292 ADSSKLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPN 351
            D ++L   +A + EV+R+  + PLA P R  + + I GY IP+ T ++ +L   HLD  
Sbjct: 246 KDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDET 305

Query: 352 LWPDPHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRID 411
           +W  PHE  P+RF+ E G    N     FG G R C G+ LAR  +F++   +LQ + + 
Sbjct: 306 VWERPHEFWPDRFL-EPG---KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLL 361

Query: 412 CVNGVLPS 419
                LPS
Sbjct: 362 PSGDALPS 369


>AF019413-2|AAB67982.1|  495|Homo sapiens cytochrome P450
           21-hydroxylase protein.
          Length = 495

 Score =  113 bits (273), Expect = 9e-25
 Identities = 61/188 (32%), Positives = 103/188 (54%), Gaps = 8/188 (4%)

Query: 236 LNDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG----DSMPCW 291
           L   +    +DL+I G++TT N + +A++ +L +  IQ+++  E+++ +G     S   +
Sbjct: 278 LEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPY 337

Query: 292 ADSSKLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPN 351
            D ++L   +A + EV+R+  + PLA P R  + + I GY IP+ T ++ +L   HLD  
Sbjct: 338 KDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDET 397

Query: 352 LWPDPHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRID 411
           +W  PHE  P+RF+ E G    N     FG G R C G+ LAR  +F++   +LQ + + 
Sbjct: 398 VWERPHEFWPDRFL-EPG---KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLL 453

Query: 412 CVNGVLPS 419
                LPS
Sbjct: 454 PSGDALPS 461


>AK027605-1|BAB55227.1|  564|Homo sapiens protein ( Homo sapiens
           cDNA FLJ14699 fis, clone NT2RP2006571, moderately
           similar to CYTOCHROME P450 2G1 (EC 1.14.14.1). ).
          Length = 564

 Score =  112 bits (270), Expect = 2e-24
 Identities = 55/176 (31%), Positives = 94/176 (53%), Gaps = 1/176 (0%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSM-PCWADSS 295
           N  +    + L+ AG+ T    V + LL +++  ++Q+ +  E+   +G    P   D +
Sbjct: 289 NKNMLMTVIYLLFAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRT 348

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
           +L YT A L E  R+  + P+  PR +++ T   GY +P+ T V   L  I  DPN++  
Sbjct: 349 RLPYTDAVLHEAQRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKH 408

Query: 356 PHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRID 411
           P E  P+RF+D  G  + +E   PF  G+R C G+ LA++ +F+ F  ILQ + ++
Sbjct: 409 PEEFNPDRFLDADGRFRKHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLE 464



 Score = 60.9 bits (141), Expect = 9e-09
 Identities = 52/173 (30%), Positives = 81/173 (46%), Gaps = 12/173 (6%)

Query: 33  MAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGR-ELVVVVYGEK 91
           + PGP   P  G+      +  + G+ +  L+ LSK++   V  + LG    VVV+ G++
Sbjct: 32  LPPGPTPLPLLGNL-----LQLRPGALYSGLMRLSKKYGP-VFTIYLGPWRPVVVLVGQE 85

Query: 92  NVRQVFS--ESEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKT 149
            VR+       EF GR      +    G   GV F +G  WR+ R+FT+  L+++G GK 
Sbjct: 86  AVREALGGQAEEFSGRGTVAMLEGTFDGH--GVFFSNGERWRQLRKFTMLALRDLGMGKR 143

Query: 150 SMELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERIR-EDK 201
             E  IQ E + L E     + +P     + + A  NV+   + G R   EDK
Sbjct: 144 EGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSNVVCSLLFGLRFSYEDK 196


>M17252-1|AAA59985.1|  230|Homo sapiens CYP21 protein.
          Length = 230

 Score =  112 bits (269), Expect = 3e-24
 Identities = 61/188 (32%), Positives = 102/188 (54%), Gaps = 8/188 (4%)

Query: 236 LNDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG----DSMPCW 291
           L   +    +DL+I G++TT N + +A++ +L +  IQ+++  E+++ +G     S   +
Sbjct: 13  LEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHLEIQQRLQEELDHELGPGASSSRVPY 72

Query: 292 ADSSKLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPN 351
            D ++L    A + EV+R+  + PLA P R  + + I GY IP+ T ++ +L   HLD  
Sbjct: 73  KDRARLPLLIATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDET 132

Query: 352 LWPDPHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRID 411
           +W  PHE  P+RF+ E G    N     FG G R C G+ LAR  +F++   +LQ + + 
Sbjct: 133 VWERPHEFWPDRFL-EPG---KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLL 188

Query: 412 CVNGVLPS 419
                LPS
Sbjct: 189 PSGDALPS 196


>BT019979-1|AAV38782.1|  543|Homo sapiens cytochrome P450, family 1,
           subfamily B, polypeptide 1 protein.
          Length = 543

 Score =  112 bits (269), Expect = 3e-24
 Identities = 66/200 (33%), Positives = 99/200 (49%), Gaps = 5/200 (2%)

Query: 246 DLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSKLVYTSAFL 304
           D+  A   T   A+++ LL   R  ++Q ++  E++  +G D +PC  D   L Y  AFL
Sbjct: 326 DIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFL 385

Query: 305 LEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERF 364
            E MR  +  P+  P     +T + GY IPK+T V ++   ++ DP  WP+P    P RF
Sbjct: 386 YEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNPENFDPARF 445

Query: 365 IDEKGL-SKS-NEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGVLPSN-E 421
           +D+ GL SK     +  F  G+RRC G+ L++  +F +F+ IL        N   P+   
Sbjct: 446 LDKDGLISKDLTSRVMIFSVGKRRCIGEELSKMQLF-LFISILAHQCDFRANPNEPAKMN 504

Query: 422 ADIGLLAAPKPFVANFVSRE 441
              GL   PK F  N   RE
Sbjct: 505 FSYGLTIKPKSFKVNVTLRE 524


>AM183949-1|CAJ75803.1|  494|Homo sapiens steroid 21-hydroxylase,
           CYP21 protein.
          Length = 494

 Score =  112 bits (269), Expect = 3e-24
 Identities = 60/188 (31%), Positives = 102/188 (54%), Gaps = 8/188 (4%)

Query: 236 LNDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG----DSMPCW 291
           L   +    +DL+I G++TT N + +A++ +  +  IQ+++  E+++ +G     S   +
Sbjct: 277 LEGHVHMAAVDLLIGGTETTANTLSWAVVFLFHHPEIQQRLQEELDHELGPGASSSRVPY 336

Query: 292 ADSSKLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPN 351
            D ++L   +A + EV+R+  + PLA P R  + + I GY IP+ T ++ +L   HLD  
Sbjct: 337 KDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDET 396

Query: 352 LWPDPHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRID 411
           +W  PHE  P+RF+ E G    N     FG G R C G+ LAR  +F++   +LQ + + 
Sbjct: 397 VWERPHEFWPDRFL-EPG---KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLL 452

Query: 412 CVNGVLPS 419
                LPS
Sbjct: 453 PSGDALPS 460


>AK054616-1|BAB70774.1|  465|Homo sapiens protein ( Homo sapiens
           cDNA FLJ30054 fis, clone ADRGL1000160, highly similar to
           CYTOCHROME P450 XXIB (EC 1.14.99.10). ).
          Length = 465

 Score =  112 bits (269), Expect = 3e-24
 Identities = 60/179 (33%), Positives = 100/179 (55%), Gaps = 8/179 (4%)

Query: 245 LDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG----DSMPCWADSSKLVYT 300
           +DL+I G++TT N + +A + +L +  IQ+++  E+++ +G     S   + D ++L   
Sbjct: 257 VDLLIGGTETTANTLSWAAVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLL 316

Query: 301 SAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIK 360
           +A + EV+R+  + PLA P R  + + I GY IP+ T ++ +L   HLD  +W  PHE  
Sbjct: 317 NATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFW 376

Query: 361 PERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGVLPS 419
           P+RF+ E G    N     FG G R C G+ LAR  +F++   +LQ + +      LPS
Sbjct: 377 PDRFL-EPG---KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPS 431


>X02612-1|CAA26458.1|  512|Homo sapiens cytochrome P(1)-450 protein.
          Length = 512

 Score =  111 bits (268), Expect = 4e-24
 Identities = 62/183 (33%), Positives = 99/183 (54%), Gaps = 3/183 (1%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSM-PCWADSS 295
           ++++  + LDL  AG  T   A+ ++L+ ++ N  +Q KI  E++  IG S  P  +D S
Sbjct: 304 DEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRS 363

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
            L Y  AF+LE  R  ++ P   P    +DT + G+ IPK   V ++   I+ D  LW +
Sbjct: 364 HLPYMEAFILETFRHSSLVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVN 423

Query: 356 PHEIKPERFIDEKG-LSK-SNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCV 413
           P E  PERF+   G + K  +E +  FG G+R+C G+++AR  VF+    +LQ+      
Sbjct: 424 PSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETVARWEVFLFLAILLQRVEFSVP 483

Query: 414 NGV 416
            GV
Sbjct: 484 LGV 486



 Score = 43.6 bits (98), Expect = 0.001
 Identities = 32/111 (28%), Positives = 53/111 (47%), Gaps = 9/111 (8%)

Query: 35  PGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKNVR 94
           PGP  +P  G       M +   +   AL  +S+Q+   VL +++G   VVV+ G   +R
Sbjct: 41  PGPWGWPLIG------HMLTLGKNPHLALSRMSQQYG-DVLQIRIGSTPVVVLSGLDTIR 93

Query: 95  Q--VFSESEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKN 143
           Q  V    +F GRP+ + + L   G+ +  +   GP+W   R+     LK+
Sbjct: 94  QALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKS 144


>U56438-1|AAC50809.1|  543|Homo sapiens dioxin-inducible cytochrome
           P450 protein.
          Length = 543

 Score =  111 bits (268), Expect = 4e-24
 Identities = 64/200 (32%), Positives = 98/200 (49%), Gaps = 5/200 (2%)

Query: 246 DLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSKLVYTSAFL 304
           D+  A   T   A+++ LL   R  ++Q ++  E++  +G D +PC  D   L Y  AFL
Sbjct: 326 DIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFL 385

Query: 305 LEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERF 364
            E MR  +  P+  P     +T + GY IPK+T V ++   ++ DP  WP+P    P RF
Sbjct: 386 YEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNPENFDPARF 445

Query: 365 IDEKGLSKSN--EHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGVLPSN-E 421
           +D+ GL   +    +  F  G+RRC G+ L++  +F +F+ IL        N   P+   
Sbjct: 446 LDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLF-LFISILAHQCDFRANPNEPAKMN 504

Query: 422 ADIGLLAAPKPFVANFVSRE 441
              GL   PK F  N   RE
Sbjct: 505 FSYGLTIKPKSFKVNVTLRE 524


>U03688-1|AAA19567.1|  543|Homo sapiens cytochrome P450 protein.
          Length = 543

 Score =  111 bits (268), Expect = 4e-24
 Identities = 64/200 (32%), Positives = 98/200 (49%), Gaps = 5/200 (2%)

Query: 246 DLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSKLVYTSAFL 304
           D+  A   T   A+++ LL   R  ++Q ++  E++  +G D +PC  D   L Y  AFL
Sbjct: 326 DIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFL 385

Query: 305 LEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERF 364
            E MR  +  P+  P     +T + GY IPK+T V ++   ++ DP  WP+P    P RF
Sbjct: 386 YEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPVKWPNPENFDPARF 445

Query: 365 IDEKGLSKSN--EHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGVLPSN-E 421
           +D+ GL   +    +  F  G+RRC G+ L++  +F +F+ IL        N   P+   
Sbjct: 446 LDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLF-LFISILAHQCDFRANPNEPAKMN 504

Query: 422 ADIGLLAAPKPFVANFVSRE 441
              GL   PK F  N   RE
Sbjct: 505 FSYGLTIKPKSFKVNVTLRE 524


>M63871-1|AAA59984.1|  508|Homo sapiens CYP17 protein.
          Length = 508

 Score =  111 bits (268), Expect = 4e-24
 Identities = 61/189 (32%), Positives = 107/189 (56%), Gaps = 4/189 (2%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSM-PCWADSS 295
           ++ + T   D+  AG +TT + VK+ L  +L N  +++K++ EI+  +G S  P  +D +
Sbjct: 289 DNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRN 348

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
           +L+   A + EV+R+  +AP+  P +   D+ I  + + K T V+I+L  +H +   W  
Sbjct: 349 RLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQ 408

Query: 356 PHEIKPERFIDEKG--LSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCV 413
           P +  PERF++  G  L   +    PFG+G R C G+ LAR  +F+I   +LQ++ ++  
Sbjct: 409 PDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVP 468

Query: 414 -NGVLPSNE 421
            +G LPS E
Sbjct: 469 DDGQLPSLE 477


>M31153-1|AAA52140.1|  508|Homo sapiens CYP17 protein.
          Length = 508

 Score =  111 bits (268), Expect = 4e-24
 Identities = 61/189 (32%), Positives = 107/189 (56%), Gaps = 4/189 (2%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSM-PCWADSS 295
           ++ + T   D+  AG +TT + VK+ L  +L N  +++K++ EI+  +G S  P  +D +
Sbjct: 289 DNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRN 348

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
           +L+   A + EV+R+  +AP+  P +   D+ I  + + K T V+I+L  +H +   W  
Sbjct: 349 RLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQ 408

Query: 356 PHEIKPERFIDEKG--LSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCV 413
           P +  PERF++  G  L   +    PFG+G R C G+ LAR  +F+I   +LQ++ ++  
Sbjct: 409 PDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVP 468

Query: 414 -NGVLPSNE 421
            +G LPS E
Sbjct: 469 DDGQLPSLE 477


>M19489-1|AAA36405.1|  508|Homo sapiens CYP17 protein.
          Length = 508

 Score =  111 bits (268), Expect = 4e-24
 Identities = 61/189 (32%), Positives = 107/189 (56%), Gaps = 4/189 (2%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSM-PCWADSS 295
           ++ + T   D+  AG +TT + VK+ L  +L N  +++K++ EI+  +G S  P  +D +
Sbjct: 289 DNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRN 348

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
           +L+   A + EV+R+  +AP+  P +   D+ I  + + K T V+I+L  +H +   W  
Sbjct: 349 RLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQ 408

Query: 356 PHEIKPERFIDEKG--LSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCV 413
           P +  PERF++  G  L   +    PFG+G R C G+ LAR  +F+I   +LQ++ ++  
Sbjct: 409 PDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVP 468

Query: 414 -NGVLPSNE 421
            +G LPS E
Sbjct: 469 DDGQLPSLE 477


>M14564-1|AAA52151.1|  508|Homo sapiens CYP17 protein.
          Length = 508

 Score =  111 bits (268), Expect = 4e-24
 Identities = 61/189 (32%), Positives = 107/189 (56%), Gaps = 4/189 (2%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSM-PCWADSS 295
           ++ + T   D+  AG +TT + VK+ L  +L N  +++K++ EI+  +G S  P  +D +
Sbjct: 289 DNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRN 348

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
           +L+   A + EV+R+  +AP+  P +   D+ I  + + K T V+I+L  +H +   W  
Sbjct: 349 RLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQ 408

Query: 356 PHEIKPERFIDEKG--LSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCV 413
           P +  PERF++  G  L   +    PFG+G R C G+ LAR  +F+I   +LQ++ ++  
Sbjct: 409 PDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVP 468

Query: 414 -NGVLPSNE 421
            +G LPS E
Sbjct: 469 DDGQLPSLE 477


>DQ530598-1|ABF50972.1|  508|Homo sapiens cytochrome P450, family
           17, subfamily A, polypeptide 1 protein.
          Length = 508

 Score =  111 bits (268), Expect = 4e-24
 Identities = 61/189 (32%), Positives = 107/189 (56%), Gaps = 4/189 (2%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSM-PCWADSS 295
           ++ + T   D+  AG +TT + VK+ L  +L N  +++K++ EI+  +G S  P  +D +
Sbjct: 289 DNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRN 348

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
           +L+   A + EV+R+  +AP+  P +   D+ I  + + K T V+I+L  +H +   W  
Sbjct: 349 RLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQ 408

Query: 356 PHEIKPERFIDEKG--LSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCV 413
           P +  PERF++  G  L   +    PFG+G R C G+ LAR  +F+I   +LQ++ ++  
Sbjct: 409 PDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVP 468

Query: 414 -NGVLPSNE 421
            +G LPS E
Sbjct: 469 DDGQLPSLE 477


>BT020001-1|AAV38804.1|  543|Homo sapiens cytochrome P450, family 1,
           subfamily B, polypeptide 1 protein.
          Length = 543

 Score =  111 bits (268), Expect = 4e-24
 Identities = 64/200 (32%), Positives = 98/200 (49%), Gaps = 5/200 (2%)

Query: 246 DLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSKLVYTSAFL 304
           D+  A   T   A+++ LL   R  ++Q ++  E++  +G D +PC  D   L Y  AFL
Sbjct: 326 DIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFL 385

Query: 305 LEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERF 364
            E MR  +  P+  P     +T + GY IPK+T V ++   ++ DP  WP+P    P RF
Sbjct: 386 YEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPVKWPNPENFDPARF 445

Query: 365 IDEKGLSKSN--EHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGVLPSN-E 421
           +D+ GL   +    +  F  G+RRC G+ L++  +F +F+ IL        N   P+   
Sbjct: 446 LDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLF-LFISILAHQCDFRANPNEPAKMN 504

Query: 422 ADIGLLAAPKPFVANFVSRE 441
              GL   PK F  N   RE
Sbjct: 505 FSYGLTIKPKSFKVNVTLRE 524


>BT020000-1|AAV38803.1|  508|Homo sapiens cytochrome P450, family
           17, subfamily A, polypeptide 1 protein.
          Length = 508

 Score =  111 bits (268), Expect = 4e-24
 Identities = 61/189 (32%), Positives = 107/189 (56%), Gaps = 4/189 (2%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSM-PCWADSS 295
           ++ + T   D+  AG +TT + VK+ L  +L N  +++K++ EI+  +G S  P  +D +
Sbjct: 289 DNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRN 348

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
           +L+   A + EV+R+  +AP+  P +   D+ I  + + K T V+I+L  +H +   W  
Sbjct: 349 RLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQ 408

Query: 356 PHEIKPERFIDEKG--LSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCV 413
           P +  PERF++  G  L   +    PFG+G R C G+ LAR  +F+I   +LQ++ ++  
Sbjct: 409 PDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVP 468

Query: 414 -NGVLPSNE 421
            +G LPS E
Sbjct: 469 DDGQLPSLE 477


>BC063388-1|AAH63388.1|  508|Homo sapiens cytochrome P450, family
           17, subfamily A, polypeptide 1 protein.
          Length = 508

 Score =  111 bits (268), Expect = 4e-24
 Identities = 61/189 (32%), Positives = 107/189 (56%), Gaps = 4/189 (2%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSM-PCWADSS 295
           ++ + T   D+  AG +TT + VK+ L  +L N  +++K++ EI+  +G S  P  +D +
Sbjct: 289 DNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRN 348

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
           +L+   A + EV+R+  +AP+  P +   D+ I  + + K T V+I+L  +H +   W  
Sbjct: 349 RLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQ 408

Query: 356 PHEIKPERFIDEKG--LSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCV 413
           P +  PERF++  G  L   +    PFG+G R C G+ LAR  +F+I   +LQ++ ++  
Sbjct: 409 PDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVP 468

Query: 414 -NGVLPSNE 421
            +G LPS E
Sbjct: 469 DDGQLPSLE 477


>BC062997-1|AAH62997.1|  508|Homo sapiens cytochrome P450, family
           17, subfamily A, polypeptide 1 protein.
          Length = 508

 Score =  111 bits (268), Expect = 4e-24
 Identities = 61/189 (32%), Positives = 107/189 (56%), Gaps = 4/189 (2%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSM-PCWADSS 295
           ++ + T   D+  AG +TT + VK+ L  +L N  +++K++ EI+  +G S  P  +D +
Sbjct: 289 DNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRN 348

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
           +L+   A + EV+R+  +AP+  P +   D+ I  + + K T V+I+L  +H +   W  
Sbjct: 349 RLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQ 408

Query: 356 PHEIKPERFIDEKG--LSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCV 413
           P +  PERF++  G  L   +    PFG+G R C G+ LAR  +F+I   +LQ++ ++  
Sbjct: 409 PDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVP 468

Query: 414 -NGVLPSNE 421
            +G LPS E
Sbjct: 469 DDGQLPSLE 477


>BC012049-1|AAH12049.1|  543|Homo sapiens cytochrome P450, family 1,
           subfamily B, polypeptide 1 protein.
          Length = 543

 Score =  111 bits (268), Expect = 4e-24
 Identities = 64/200 (32%), Positives = 98/200 (49%), Gaps = 5/200 (2%)

Query: 246 DLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSKLVYTSAFL 304
           D+  A   T   A+++ LL   R  ++Q ++  E++  +G D +PC  D   L Y  AFL
Sbjct: 326 DIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFL 385

Query: 305 LEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERF 364
            E MR  +  P+  P     +T + GY IPK+T V ++   ++ DP  WP+P    P RF
Sbjct: 386 YEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPVKWPNPENFDPARF 445

Query: 365 IDEKGLSKSN--EHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGVLPSN-E 421
           +D+ GL   +    +  F  G+RRC G+ L++  +F +F+ IL        N   P+   
Sbjct: 446 LDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLF-LFISILAHQCDFRANPNEPAKMN 504

Query: 422 ADIGLLAAPKPFVANFVSRE 441
              GL   PK F  N   RE
Sbjct: 505 FSYGLTIKPKSFKVNVTLRE 524


>AY393998-1|AAQ87875.1|  543|Homo sapiens cytochrome P450, family 1,
           subfamily B, polypeptide 1 protein.
          Length = 543

 Score =  111 bits (268), Expect = 4e-24
 Identities = 64/200 (32%), Positives = 98/200 (49%), Gaps = 5/200 (2%)

Query: 246 DLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSKLVYTSAFL 304
           D+  A   T   A+++ LL   R  ++Q ++  E++  +G D +PC  D   L Y  AFL
Sbjct: 326 DIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFL 385

Query: 305 LEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERF 364
            E MR  +  P+  P     +T + GY IPK+T V ++   ++ DP  WP+P    P RF
Sbjct: 386 YEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNPENFDPARF 445

Query: 365 IDEKGLSKSN--EHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGVLPSN-E 421
           +D+ GL   +    +  F  G+RRC G+ L++  +F +F+ IL        N   P+   
Sbjct: 446 LDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLF-LFISILAHQCDFRANPNEPAKMN 504

Query: 422 ADIGLLAAPKPFVANFVSRE 441
              GL   PK F  N   RE
Sbjct: 505 FSYGLTIKPKSFKVNVTLRE 524


>AM183948-1|CAJ75802.1|  494|Homo sapiens steroid 21-hydroxylase
           protein.
          Length = 494

 Score =  111 bits (268), Expect = 4e-24
 Identities = 60/188 (31%), Positives = 102/188 (54%), Gaps = 8/188 (4%)

Query: 236 LNDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG----DSMPCW 291
           L   +    +DL+I G++ T N + +A++ +L +  IQ+++  E+++ +G     S   +
Sbjct: 277 LEGHVHMAAVDLLIGGTENTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPY 336

Query: 292 ADSSKLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPN 351
            D ++L   +A + EV+R+  + PLA P R  + + I GY IP+ T ++ +L   HLD  
Sbjct: 337 KDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDET 396

Query: 352 LWPDPHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRID 411
           +W  PHE  P+RF+ E G    N     FG G R C G+ LAR  +F++   +LQ + + 
Sbjct: 397 VWERPHEFWPDRFL-EPG---KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLL 452

Query: 412 CVNGVLPS 419
                LPS
Sbjct: 453 PSGDALPS 460


>AL358790-3|CAI52498.1|  508|Homo sapiens cytochrome P450, family
           17, subfamily A, polypeptide 1 protein.
          Length = 508

 Score =  111 bits (268), Expect = 4e-24
 Identities = 61/189 (32%), Positives = 107/189 (56%), Gaps = 4/189 (2%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSM-PCWADSS 295
           ++ + T   D+  AG +TT + VK+ L  +L N  +++K++ EI+  +G S  P  +D +
Sbjct: 289 DNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRN 348

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
           +L+   A + EV+R+  +AP+  P +   D+ I  + + K T V+I+L  +H +   W  
Sbjct: 349 RLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQ 408

Query: 356 PHEIKPERFIDEKG--LSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCV 413
           P +  PERF++  G  L   +    PFG+G R C G+ LAR  +F+I   +LQ++ ++  
Sbjct: 409 PDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVP 468

Query: 414 -NGVLPSNE 421
            +G LPS E
Sbjct: 469 DDGQLPSLE 477


>AF450132-1|AAM50512.1|  543|Homo sapiens cytochrome P450 CYP1B1
           protein.
          Length = 543

 Score =  111 bits (268), Expect = 4e-24
 Identities = 64/200 (32%), Positives = 98/200 (49%), Gaps = 5/200 (2%)

Query: 246 DLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSKLVYTSAFL 304
           D+  A   T   A+++ LL   R  ++Q ++  E++  +G D +PC  D   L Y  AFL
Sbjct: 326 DIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFL 385

Query: 305 LEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERF 364
            E MR  +  P+  P     +T + GY IPK+T V ++   ++ DP  WP+P    P RF
Sbjct: 386 YEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNPENFDPARF 445

Query: 365 IDEKGLSKSN--EHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGVLPSN-E 421
           +D+ GL   +    +  F  G+RRC G+ L++  +F +F+ IL        N   P+   
Sbjct: 446 LDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLF-LFISILAHQCDFRANPNEPAKMN 504

Query: 422 ADIGLLAAPKPFVANFVSRE 441
              GL   PK F  N   RE
Sbjct: 505 FSYGLTIKPKSFKVNVTLRE 524


>AC009229-2|AAY15039.1|  543|Homo sapiens unknown protein.
          Length = 543

 Score =  111 bits (268), Expect = 4e-24
 Identities = 64/200 (32%), Positives = 98/200 (49%), Gaps = 5/200 (2%)

Query: 246 DLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSKLVYTSAFL 304
           D+  A   T   A+++ LL   R  ++Q ++  E++  +G D +PC  D   L Y  AFL
Sbjct: 326 DIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFL 385

Query: 305 LEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERF 364
            E MR  +  P+  P     +T + GY IPK+T V ++   ++ DP  WP+P    P RF
Sbjct: 386 YEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPVKWPNPENFDPARF 445

Query: 365 IDEKGLSKSN--EHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGVLPSN-E 421
           +D+ GL   +    +  F  G+RRC G+ L++  +F +F+ IL        N   P+   
Sbjct: 446 LDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLF-LFISILAHQCDFRANPNEPAKMN 504

Query: 422 ADIGLLAAPKPFVANFVSRE 441
              GL   PK F  N   RE
Sbjct: 505 FSYGLTIKPKSFKVNVTLRE 524


>X04300-1|CAA27843.1|  512|Homo sapiens P-450 c protein.
          Length = 512

 Score =  111 bits (267), Expect = 5e-24
 Identities = 62/183 (33%), Positives = 98/183 (53%), Gaps = 3/183 (1%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSM-PCWADSS 295
           ++++  + LDL  AG  T   A+ ++L+ ++ N  +Q KI  E++  IG S  P  +D S
Sbjct: 304 DEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRS 363

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
            L Y  AF+LE  R  +  P   P    +DT + G+ IPK   V ++   I+ D  LW +
Sbjct: 364 HLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVN 423

Query: 356 PHEIKPERFIDEKG-LSK-SNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCV 413
           P E  PERF+   G + K  +E +  FG G+R+C G+++AR  VF+    +LQ+      
Sbjct: 424 PSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVP 483

Query: 414 NGV 416
            GV
Sbjct: 484 LGV 486



 Score = 43.6 bits (98), Expect = 0.001
 Identities = 32/111 (28%), Positives = 53/111 (47%), Gaps = 9/111 (8%)

Query: 35  PGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKNVR 94
           PGP  +P  G       M +   +   AL  +S+Q+   VL +++G   VVV+ G   +R
Sbjct: 41  PGPWGWPLIG------HMLTLGKNPHLALSRMSQQYG-DVLQIRIGSTPVVVLSGLDTIR 93

Query: 95  Q--VFSESEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKN 143
           Q  V    +F GRP+ + + L   G+ +  +   GP+W   R+     LK+
Sbjct: 94  QALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKS 144


>M61856-1|AAB59356.1|  490|Homo sapiens cytochrome protein.
          Length = 490

 Score =  111 bits (267), Expect = 5e-24
 Identities = 55/174 (31%), Positives = 91/174 (52%), Gaps = 1/174 (0%)

Query: 238 DQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSK 296
           + L     D+  AG++TT   +++ LL +L+   +  K+  EIE  +G +  PC  D S 
Sbjct: 285 ESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSH 344

Query: 297 LVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDP 356
           + YT A + E+ R   + P   P  V  D     Y+IPK TT++ SL  +  +   +P+P
Sbjct: 345 MPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNP 404

Query: 357 HEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRI 410
               P  F+D+ G  K +++  PF +G+R C G+ LAR  +F+    ILQ + +
Sbjct: 405 EMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNL 458



 Score = 63.3 bits (147), Expect = 2e-09
 Identities = 50/178 (28%), Positives = 84/178 (47%), Gaps = 12/178 (6%)

Query: 36  GPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKNVRQ 95
           GP   P  G+   + Q+  K  S  K+L   SK +   V  +  G + +VV++G + V++
Sbjct: 32  GPTPLPIIGN---ILQLDVKDMS--KSLTNFSKVYGP-VFTVYFGLKPIVVLHGYEAVKE 85

Query: 96  VFSE--SEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTSMEL 153
              +   EF GR +  F     + K LG+ F +G  W+E R+F +  L+N G GK S+E 
Sbjct: 86  ALIDHGEEFSGRGS--FPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIED 143

Query: 154 EIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERI--REDKLERLLELF 209
            +Q E + L E +      P     +   A  NV+   +  +R   ++ +   L+E F
Sbjct: 144 RVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKF 201


>EF094025-1|ABK41999.1|  512|Homo sapiens cytochrome P450, family 1,
           subfamily A, polypeptide 1 protein.
          Length = 512

 Score =  111 bits (267), Expect = 5e-24
 Identities = 62/183 (33%), Positives = 98/183 (53%), Gaps = 3/183 (1%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSM-PCWADSS 295
           ++++  + LDL  AG  T   A+ ++L+ ++ N  +Q KI  E++  IG S  P  +D S
Sbjct: 304 DEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRS 363

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
            L Y  AF+LE  R  +  P   P    +DT + G+ IPK   V ++   I+ D  LW +
Sbjct: 364 HLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVN 423

Query: 356 PHEIKPERFIDEKG-LSK-SNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCV 413
           P E  PERF+   G + K  +E +  FG G+R+C G+++AR  VF+    +LQ+      
Sbjct: 424 PSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVP 483

Query: 414 NGV 416
            GV
Sbjct: 484 LGV 486



 Score = 43.6 bits (98), Expect = 0.001
 Identities = 32/111 (28%), Positives = 53/111 (47%), Gaps = 9/111 (8%)

Query: 35  PGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKNVR 94
           PGP  +P  G       M +   +   AL  +S+Q+   VL +++G   VVV+ G   +R
Sbjct: 41  PGPWGWPLIG------HMLTLGKNPHLALSRMSQQYG-DVLQIRIGSTPVVVLSGLDTIR 93

Query: 95  Q--VFSESEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKN 143
           Q  V    +F GRP+ + + L   G+ +  +   GP+W   R+     LK+
Sbjct: 94  QALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKS 144


>BC096258-1|AAH96258.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 18 protein.
          Length = 490

 Score =  111 bits (267), Expect = 5e-24
 Identities = 55/174 (31%), Positives = 91/174 (52%), Gaps = 1/174 (0%)

Query: 238 DQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSK 296
           + L     D+  AG++TT   +++ LL +L+   +  K+  EIE  +G +  PC  D S 
Sbjct: 285 ESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSH 344

Query: 297 LVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDP 356
           + YT A + E+ R   + P   P  V  D     Y+IPK TT++ SL  +  +   +P+P
Sbjct: 345 MPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNP 404

Query: 357 HEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRI 410
               P  F+D+ G  K +++  PF +G+R C G+ LAR  +F+    ILQ + +
Sbjct: 405 EMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNL 458



 Score = 63.3 bits (147), Expect = 2e-09
 Identities = 50/178 (28%), Positives = 84/178 (47%), Gaps = 12/178 (6%)

Query: 36  GPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKNVRQ 95
           GP   P  G+   + Q+  K  S  K+L   SK +   V  +  G + +VV++G + V++
Sbjct: 32  GPTPLPIIGN---ILQLDVKDMS--KSLTNFSKVYGP-VFTVYFGLKPIVVLHGYEAVKE 85

Query: 96  VFSE--SEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTSMEL 153
              +   EF GR +  F     + K LG+ F +G  W+E R+F +  L+N G GK S+E 
Sbjct: 86  ALIDHGEEFSGRGS--FPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIED 143

Query: 154 EIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERI--REDKLERLLELF 209
            +Q E + L E +      P     +   A  NV+   +  +R   ++ +   L+E F
Sbjct: 144 RVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKF 201


>BC096257-1|AAH96257.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 18 protein.
          Length = 490

 Score =  111 bits (267), Expect = 5e-24
 Identities = 55/174 (31%), Positives = 91/174 (52%), Gaps = 1/174 (0%)

Query: 238 DQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSK 296
           + L     D+  AG++TT   +++ LL +L+   +  K+  EIE  +G +  PC  D S 
Sbjct: 285 ESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSH 344

Query: 297 LVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDP 356
           + YT A + E+ R   + P   P  V  D     Y+IPK TT++ SL  +  +   +P+P
Sbjct: 345 MPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNP 404

Query: 357 HEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRI 410
               P  F+D+ G  K +++  PF +G+R C G+ LAR  +F+    ILQ + +
Sbjct: 405 EMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNL 458



 Score = 63.3 bits (147), Expect = 2e-09
 Identities = 50/178 (28%), Positives = 84/178 (47%), Gaps = 12/178 (6%)

Query: 36  GPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKNVRQ 95
           GP   P  G+   + Q+  K  S  K+L   SK +   V  +  G + +VV++G + V++
Sbjct: 32  GPTPLPIIGN---ILQLDVKDMS--KSLTNFSKVYGP-VFTVYFGLKPIVVLHGYEAVKE 85

Query: 96  VFSE--SEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTSMEL 153
              +   EF GR +  F     + K LG+ F +G  W+E R+F +  L+N G GK S+E 
Sbjct: 86  ALIDHGEEFSGRGS--FPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIED 143

Query: 154 EIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERI--REDKLERLLELF 209
            +Q E + L E +      P     +   A  NV+   +  +R   ++ +   L+E F
Sbjct: 144 RVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKF 201


>BC069666-1|AAH69666.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 18 protein.
          Length = 490

 Score =  111 bits (267), Expect = 5e-24
 Identities = 55/174 (31%), Positives = 91/174 (52%), Gaps = 1/174 (0%)

Query: 238 DQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSK 296
           + L     D+  AG++TT   +++ LL +L+   +  K+  EIE  +G +  PC  D S 
Sbjct: 285 ESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSH 344

Query: 297 LVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDP 356
           + YT A + E+ R   + P   P  V  D     Y+IPK TT++ SL  +  +   +P+P
Sbjct: 345 MPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNP 404

Query: 357 HEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRI 410
               P  F+D+ G  K +++  PF +G+R C G+ LAR  +F+    ILQ + +
Sbjct: 405 EMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNL 458



 Score = 63.3 bits (147), Expect = 2e-09
 Identities = 50/178 (28%), Positives = 84/178 (47%), Gaps = 12/178 (6%)

Query: 36  GPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKNVRQ 95
           GP   P  G+   + Q+  K  S  K+L   SK +   V  +  G + +VV++G + V++
Sbjct: 32  GPTPLPIIGN---ILQLDVKDMS--KSLTNFSKVYGP-VFTVYFGLKPIVVLHGYEAVKE 85

Query: 96  VFSE--SEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTSMEL 153
              +   EF GR +  F     + K LG+ F +G  W+E R+F +  L+N G GK S+E 
Sbjct: 86  ALIDHGEEFSGRGS--FPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIED 143

Query: 154 EIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERI--REDKLERLLELF 209
            +Q E + L E +      P     +   A  NV+   +  +R   ++ +   L+E F
Sbjct: 144 RVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKF 201


>BC023019-1|AAH23019.1|  512|Homo sapiens cytochrome P450, family 1,
           subfamily A, polypeptide 1 protein.
          Length = 512

 Score =  111 bits (267), Expect = 5e-24
 Identities = 62/183 (33%), Positives = 98/183 (53%), Gaps = 3/183 (1%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSM-PCWADSS 295
           ++++  + LDL  AG  T   A+ ++L+ ++ N  +Q KI  E++  IG S  P  +D S
Sbjct: 304 DEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRS 363

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
            L Y  AF+LE  R  +  P   P    +DT + G+ IPK   V ++   I+ D  LW +
Sbjct: 364 HLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVN 423

Query: 356 PHEIKPERFIDEKG-LSK-SNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCV 413
           P E  PERF+   G + K  +E +  FG G+R+C G+++AR  VF+    +LQ+      
Sbjct: 424 PSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVP 483

Query: 414 NGV 416
            GV
Sbjct: 484 LGV 486



 Score = 43.6 bits (98), Expect = 0.001
 Identities = 32/111 (28%), Positives = 53/111 (47%), Gaps = 9/111 (8%)

Query: 35  PGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKNVR 94
           PGP  +P  G       M +   +   AL  +S+Q+   VL +++G   VVV+ G   +R
Sbjct: 41  PGPWGWPLIG------HMLTLGKNPHLALSRMSQQYG-DVLQIRIGSTPVVVLSGLDTIR 93

Query: 95  Q--VFSESEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKN 143
           Q  V    +F GRP+ + + L   G+ +  +   GP+W   R+     LK+
Sbjct: 94  QALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKS 144


>AY310359-1|AAQ76692.1|  484|Homo sapiens cytochrome P450 1A1
           variant protein.
          Length = 484

 Score =  111 bits (267), Expect = 5e-24
 Identities = 62/183 (33%), Positives = 98/183 (53%), Gaps = 3/183 (1%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSM-PCWADSS 295
           ++++  + LDL  AG  T   A+ ++L+ ++ N  +Q KI  E++  IG S  P  +D S
Sbjct: 276 DEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRS 335

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
            L Y  AF+LE  R  +  P   P    +DT + G+ IPK   V ++   I+ D  LW +
Sbjct: 336 HLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVN 395

Query: 356 PHEIKPERFIDEKG-LSK-SNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCV 413
           P E  PERF+   G + K  +E +  FG G+R+C G+++AR  VF+    +LQ+      
Sbjct: 396 PSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVP 455

Query: 414 NGV 416
            GV
Sbjct: 456 LGV 458



 Score = 43.6 bits (98), Expect = 0.001
 Identities = 32/111 (28%), Positives = 53/111 (47%), Gaps = 9/111 (8%)

Query: 35  PGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKNVR 94
           PGP  +P  G       M +   +   AL  +S+Q+   VL +++G   VVV+ G   +R
Sbjct: 41  PGPWGWPLIG------HMLTLGKNPHLALSRMSQQYG-DVLQIRIGSTPVVVLSGLDTIR 93

Query: 95  Q--VFSESEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKN 143
           Q  V    +F GRP+ + + L   G+ +  +   GP+W   R+     LK+
Sbjct: 94  QALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKS 144


>AM236047-1|CAJ84704.1|  251|Homo sapiens cytochrome P450 1A1
           protein.
          Length = 251

 Score =  111 bits (267), Expect = 5e-24
 Identities = 62/183 (33%), Positives = 98/183 (53%), Gaps = 3/183 (1%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSM-PCWADSS 295
           ++++  + LDL  AG  T   A+ ++L+ ++ N  +Q KI  E++  IG S  P  +D S
Sbjct: 43  DEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRS 102

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
            L Y  AF+LE  R  +  P   P    +DT + G+ IPK   V ++   I+ D  LW +
Sbjct: 103 HLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVN 162

Query: 356 PHEIKPERFIDEKG-LSK-SNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCV 413
           P E  PERF+   G + K  +E +  FG G+R+C G+++AR  VF+    +LQ+      
Sbjct: 163 PSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVP 222

Query: 414 NGV 416
            GV
Sbjct: 223 LGV 225


>AL583836-1|CAH74067.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 18 protein.
          Length = 490

 Score =  111 bits (267), Expect = 5e-24
 Identities = 55/174 (31%), Positives = 91/174 (52%), Gaps = 1/174 (0%)

Query: 238 DQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSK 296
           + L     D+  AG++TT   +++ LL +L+   +  K+  EIE  +G +  PC  D S 
Sbjct: 285 ESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSH 344

Query: 297 LVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDP 356
           + YT A + E+ R   + P   P  V  D     Y+IPK TT++ SL  +  +   +P+P
Sbjct: 345 MPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNP 404

Query: 357 HEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRI 410
               P  F+D+ G  K +++  PF +G+R C G+ LAR  +F+    ILQ + +
Sbjct: 405 EMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNL 458



 Score = 63.3 bits (147), Expect = 2e-09
 Identities = 50/178 (28%), Positives = 84/178 (47%), Gaps = 12/178 (6%)

Query: 36  GPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKNVRQ 95
           GP   P  G+   + Q+  K  S  K+L   SK +   V  +  G + +VV++G + V++
Sbjct: 32  GPTPLPIIGN---ILQLDVKDMS--KSLTNFSKVYGP-VFTVYFGLKPIVVLHGYEAVKE 85

Query: 96  VFSE--SEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTSMEL 153
              +   EF GR +  F     + K LG+ F +G  W+E R+F +  L+N G GK S+E 
Sbjct: 86  ALIDHGEEFSGRGS--FPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIED 143

Query: 154 EIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERI--REDKLERLLELF 209
            +Q E + L E +      P     +   A  NV+   +  +R   ++ +   L+E F
Sbjct: 144 RVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKF 201


>AK223510-1|BAD97230.1|  490|Homo sapiens cytochrome P450, family 2,
           subfamily C, polypeptide 18 variant protein.
          Length = 490

 Score =  111 bits (267), Expect = 5e-24
 Identities = 55/174 (31%), Positives = 91/174 (52%), Gaps = 1/174 (0%)

Query: 238 DQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSK 296
           + L     D+  AG++TT   +++ LL +L+   +  K+  EIE  +G +  PC  D S 
Sbjct: 285 ESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSH 344

Query: 297 LVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDP 356
           + YT A + E+ R   + P   P  V  D     Y+IPK TT++ SL  +  +   +P+P
Sbjct: 345 MPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNP 404

Query: 357 HEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRI 410
               P  F+D+ G  K +++  PF +G+R C G+ LAR  +F+    ILQ + +
Sbjct: 405 EMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNL 458



 Score = 62.1 bits (144), Expect = 4e-09
 Identities = 50/178 (28%), Positives = 84/178 (47%), Gaps = 12/178 (6%)

Query: 36  GPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKNVRQ 95
           GP   P  G+   + Q+  K  S  K+L   SK +   V  +  G + +VV++G + V++
Sbjct: 32  GPTPLPIIGN---ILQLDVKDMS--KSLTNFSKVYGP-VFTVYFGLKPIVVLHGYEAVKE 85

Query: 96  VFSE--SEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTSMEL 153
              +   EF GR +  F     + K LG+ F +G  W+E R+F +  L+N G GK S+E 
Sbjct: 86  ALIDHGEEFFGRGS--FPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIED 143

Query: 154 EIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERI--REDKLERLLELF 209
            +Q E + L E +      P     +   A  NV+   +  +R   ++ +   L+E F
Sbjct: 144 RVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKF 201


>AK223113-1|BAD96833.1|  512|Homo sapiens cytochrome P450, family 1,
           subfamily A, polypeptide 1 variant protein.
          Length = 512

 Score =  111 bits (267), Expect = 5e-24
 Identities = 62/183 (33%), Positives = 98/183 (53%), Gaps = 3/183 (1%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSM-PCWADSS 295
           ++++  + LDL  AG  T   A+ ++L+ ++ N  +Q KI  E++  IG S  P  +D S
Sbjct: 304 DEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRS 363

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
            L Y  AF+LE  R  +  P   P    +DT + G+ IPK   V ++   I+ D  LW +
Sbjct: 364 HLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVN 423

Query: 356 PHEIKPERFIDEKG-LSK-SNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCV 413
           P E  PERF+   G + K  +E +  FG G+R+C G+++AR  VF+    +LQ+      
Sbjct: 424 PSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVP 483

Query: 414 NGV 416
            GV
Sbjct: 484 LGV 486



 Score = 42.7 bits (96), Expect = 0.002
 Identities = 32/111 (28%), Positives = 53/111 (47%), Gaps = 9/111 (8%)

Query: 35  PGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKNVR 94
           PGP  +P  G       M +   +   AL  +S+Q+   VL +++G   VVV+ G   +R
Sbjct: 41  PGPWDWPLIG------HMLTLGKNPHLALSRMSQQYG-DVLQIRIGSTPVVVLSGLDTIR 93

Query: 95  Q--VFSESEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKN 143
           Q  V    +F GRP+ + + L   G+ +  +   GP+W   R+     LK+
Sbjct: 94  QALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKS 144


>AF253322-1|AAK25727.1|  512|Homo sapiens cytochrome P450 protein.
          Length = 512

 Score =  111 bits (267), Expect = 5e-24
 Identities = 62/183 (33%), Positives = 98/183 (53%), Gaps = 3/183 (1%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSM-PCWADSS 295
           ++++  + LDL  AG  T   A+ ++L+ ++ N  +Q KI  E++  IG S  P  +D S
Sbjct: 304 DEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRS 363

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
            L Y  AF+LE  R  +  P   P    +DT + G+ IPK   V ++   I+ D  LW +
Sbjct: 364 HLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVN 423

Query: 356 PHEIKPERFIDEKG-LSK-SNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCV 413
           P E  PERF+   G + K  +E +  FG G+R+C G+++AR  VF+    +LQ+      
Sbjct: 424 PSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVP 483

Query: 414 NGV 416
            GV
Sbjct: 484 LGV 486



 Score = 43.6 bits (98), Expect = 0.001
 Identities = 32/111 (28%), Positives = 53/111 (47%), Gaps = 9/111 (8%)

Query: 35  PGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKNVR 94
           PGP  +P  G       M +   +   AL  +S+Q+   VL +++G   VVV+ G   +R
Sbjct: 41  PGPWGWPLIG------HMLTLGKNPHLALSRMSQQYG-DVLQIRIGSTPVVVLSGLDTIR 93

Query: 95  Q--VFSESEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKN 143
           Q  V    +F GRP+ + + L   G+ +  +   GP+W   R+     LK+
Sbjct: 94  QALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKS 144


>Z00036-1|CAA77335.1|  515|Homo sapiens protein ( Human mRNA for
           cytochrome P-3-450. ).
          Length = 515

 Score =  111 bits (266), Expect = 6e-24
 Identities = 58/175 (33%), Positives = 94/175 (53%), Gaps = 4/175 (2%)

Query: 246 DLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSKLVYTSAFL 304
           D+  AG  T   A+ ++L+ ++    IQ KI  E++  IG +  P  +D  +L Y  AF+
Sbjct: 313 DIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFI 372

Query: 305 LEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERF 364
           LE  R  +  P   P    +DT ++G+ IPK+  V ++   ++ DP LW DP E +PERF
Sbjct: 373 LETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERF 432

Query: 365 IDEKGLSKS---NEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGV 416
           +   G + +   +E +  FG G+RRC G+ LA+  +F+    +LQ+       GV
Sbjct: 433 LTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGV 487



 Score = 31.9 bits (69), Expect = 4.6
 Identities = 22/76 (28%), Positives = 39/76 (51%), Gaps = 3/76 (3%)

Query: 62  ALLELSKQWSTQVLGLKLGRELVVVVYGEKNVRQ--VFSESEFDGRPNSFFYKLRCLGKR 119
           AL  +S+++   VL +++G   V+V+     +RQ  V    +F GRP+ +   L   G+ 
Sbjct: 64  ALSRMSQRYG-DVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQS 122

Query: 120 LGVTFVDGPLWREHRQ 135
           L  +   GP+W   R+
Sbjct: 123 LTFSTDSGPVWAARRR 138


>M55053-1|AAA52146.1|  515|Homo sapiens cytochrome P3-450 protein.
          Length = 515

 Score =  111 bits (266), Expect = 6e-24
 Identities = 58/175 (33%), Positives = 94/175 (53%), Gaps = 4/175 (2%)

Query: 246 DLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSKLVYTSAFL 304
           D+  AG  T   A+ ++L+ ++    IQ KI  E++  IG +  P  +D  +L Y  AF+
Sbjct: 313 DIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFI 372

Query: 305 LEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERF 364
           LE  R  +  P   P    +DT ++G+ IPK+  V ++   ++ DP LW DP E +PERF
Sbjct: 373 LETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERF 432

Query: 365 IDEKGLSKS---NEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGV 416
           +   G + +   +E +  FG G+RRC G+ LA+  +F+    +LQ+       GV
Sbjct: 433 LTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGV 487



 Score = 31.9 bits (69), Expect = 4.6
 Identities = 22/76 (28%), Positives = 39/76 (51%), Gaps = 3/76 (3%)

Query: 62  ALLELSKQWSTQVLGLKLGRELVVVVYGEKNVRQ--VFSESEFDGRPNSFFYKLRCLGKR 119
           AL  +S+++   VL +++G   V+V+     +RQ  V    +F GRP+ +   L   G+ 
Sbjct: 64  ALSRMSQRYG-DVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQS 122

Query: 120 LGVTFVDGPLWREHRQ 135
           L  +   GP+W   R+
Sbjct: 123 LTFSTDSGPVWAARRR 138


>M31667-1|AAA52163.1|  515|Homo sapiens CYP1A2 protein.
          Length = 515

 Score =  111 bits (266), Expect = 6e-24
 Identities = 58/175 (33%), Positives = 94/175 (53%), Gaps = 4/175 (2%)

Query: 246 DLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSKLVYTSAFL 304
           D+  AG  T   A+ ++L+ ++    IQ KI  E++  IG +  P  +D  +L Y  AF+
Sbjct: 313 DIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFI 372

Query: 305 LEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERF 364
           LE  R  +  P   P    +DT ++G+ IPK+  V ++   ++ DP LW DP E +PERF
Sbjct: 373 LETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERF 432

Query: 365 IDEKGLSKS---NEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGV 416
           +   G + +   +E +  FG G+RRC G+ LA+  +F+    +LQ+       GV
Sbjct: 433 LTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGV 487



 Score = 31.9 bits (69), Expect = 4.6
 Identities = 22/76 (28%), Positives = 39/76 (51%), Gaps = 3/76 (3%)

Query: 62  ALLELSKQWSTQVLGLKLGRELVVVVYGEKNVRQ--VFSESEFDGRPNSFFYKLRCLGKR 119
           AL  +S+++   VL +++G   V+V+     +RQ  V    +F GRP+ +   L   G+ 
Sbjct: 64  ALSRMSQRYG-DVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQS 122

Query: 120 LGVTFVDGPLWREHRQ 135
           L  +   GP+W   R+
Sbjct: 123 LTFSTDSGPVWAARRR 138


>M12792-1|AAB59440.1|  494|Homo sapiens steroid 21-hydroxylase
           protein.
          Length = 494

 Score =  111 bits (266), Expect = 6e-24
 Identities = 60/188 (31%), Positives = 102/188 (54%), Gaps = 8/188 (4%)

Query: 236 LNDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG----DSMPCW 291
           L   +    +DL+I G++TT N + +A++ +L +  IQ+++  E+++ +G     S   +
Sbjct: 277 LEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPY 336

Query: 292 ADSSKLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPN 351
            D ++L   +A + EV+R+  + PLA P R  + + I GY IP+ T ++ +L   HLD  
Sbjct: 337 KDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDET 396

Query: 352 LWPDPHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRID 411
           +W  PHE  P+RF+ E G    N     FG G   C G+ LAR  +F++   +LQ + + 
Sbjct: 397 VWERPHEFWPDRFL-EPG---KNSRALAFGCGAPVCLGEPLARLDLFVVLTRLLQAFTLL 452

Query: 412 CVNGVLPS 419
                LPS
Sbjct: 453 PSGDALPS 460


>L00389-1|AAA35738.1|  516|Homo sapiens protein ( Human cytochrome
           P-450 4 gene, exon 7, and three Alu repeats in the 3'
           flank. ).
          Length = 516

 Score =  111 bits (266), Expect = 6e-24
 Identities = 58/175 (33%), Positives = 94/175 (53%), Gaps = 4/175 (2%)

Query: 246 DLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSKLVYTSAFL 304
           D+  AG  T   A+ ++L+ ++    IQ KI  E++  IG +  P  +D  +L Y  AF+
Sbjct: 313 DIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFI 372

Query: 305 LEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERF 364
           LE  R  +  P   P    +DT ++G+ IPK+  V ++   ++ DP LW DP E +PERF
Sbjct: 373 LETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERF 432

Query: 365 IDEKGLSKS---NEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGV 416
           +   G + +   +E +  FG G+RRC G+ LA+  +F+    +LQ+       GV
Sbjct: 433 LTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGV 487



 Score = 31.1 bits (67), Expect = 8.1
 Identities = 22/76 (28%), Positives = 38/76 (50%), Gaps = 3/76 (3%)

Query: 62  ALLELSKQWSTQVLGLKLGRELVVVVYGEKNVRQ--VFSESEFDGRPNSFFYKLRCLGKR 119
           AL  +S+++   VL + +G   V+V+     +RQ  V    +F GRP+ +   L   G+ 
Sbjct: 64  ALSRMSQRYG-DVLQISIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQS 122

Query: 120 LGVTFVDGPLWREHRQ 135
           L  +   GP+W   R+
Sbjct: 123 LTFSTDSGPVWAARRR 138


>K03191-1|AAA52139.1|  512|Homo sapiens CYP1A1 protein.
          Length = 512

 Score =  111 bits (266), Expect = 6e-24
 Identities = 62/183 (33%), Positives = 98/183 (53%), Gaps = 3/183 (1%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSM-PCWADSS 295
           ++++  + LDL  AG  T   A+ ++L+ ++ N  +Q KI  E++  IG S  P  +D S
Sbjct: 304 DEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRS 363

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
            L Y  AF+LE  R  +  P   P    +DT + G+ IPK   V ++   I+ D  LW +
Sbjct: 364 HLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVN 423

Query: 356 PHEIKPERFIDEKG-LSK-SNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCV 413
           P E  PERF+   G + K  +E +  FG G+R+C G+++AR  VF+    +LQ+      
Sbjct: 424 PSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETVARWEVFLFLAILLQRVEFSVP 483

Query: 414 NGV 416
            GV
Sbjct: 484 LGV 486



 Score = 43.6 bits (98), Expect = 0.001
 Identities = 32/111 (28%), Positives = 53/111 (47%), Gaps = 9/111 (8%)

Query: 35  PGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKNVR 94
           PGP  +P  G       M +   +   AL  +S+Q+   VL +++G   VVV+ G   +R
Sbjct: 41  PGPWGWPLIG------HMLTLGKNPHLALSRMSQQYG-DVLQIRIGSTPVVVLSGLDTIR 93

Query: 95  Q--VFSESEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKN 143
           Q  V    +F GRP+ + + L   G+ +  +   GP+W   R+     LK+
Sbjct: 94  QALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKS 144


>DQ022432-1|AAY26399.1|  516|Homo sapiens cytochrome P450, family 1,
           subfamily A, polypeptide 2 protein.
          Length = 516

 Score =  111 bits (266), Expect = 6e-24
 Identities = 58/175 (33%), Positives = 94/175 (53%), Gaps = 4/175 (2%)

Query: 246 DLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSKLVYTSAFL 304
           D+  AG  T   A+ ++L+ ++    IQ KI  E++  IG +  P  +D  +L Y  AF+
Sbjct: 313 DIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFI 372

Query: 305 LEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERF 364
           LE  R  +  P   P    +DT ++G+ IPK+  V ++   ++ DP LW DP E +PERF
Sbjct: 373 LETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERF 432

Query: 365 IDEKGLSKS---NEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGV 416
           +   G + +   +E +  FG G+RRC G+ LA+  +F+    +LQ+       GV
Sbjct: 433 LTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGV 487



 Score = 31.9 bits (69), Expect = 4.6
 Identities = 22/76 (28%), Positives = 39/76 (51%), Gaps = 3/76 (3%)

Query: 62  ALLELSKQWSTQVLGLKLGRELVVVVYGEKNVRQ--VFSESEFDGRPNSFFYKLRCLGKR 119
           AL  +S+++   VL +++G   V+V+     +RQ  V    +F GRP+ +   L   G+ 
Sbjct: 64  ALSRMSQRYG-DVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQS 122

Query: 120 LGVTFVDGPLWREHRQ 135
           L  +   GP+W   R+
Sbjct: 123 LTFSTDSGPVWAARRR 138


>BC067428-1|AAH67428.1|  516|Homo sapiens cytochrome P450, family 1,
           subfamily A, polypeptide 2 protein.
          Length = 516

 Score =  111 bits (266), Expect = 6e-24
 Identities = 58/175 (33%), Positives = 94/175 (53%), Gaps = 4/175 (2%)

Query: 246 DLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSKLVYTSAFL 304
           D+  AG  T   A+ ++L+ ++    IQ KI  E++  IG +  P  +D  +L Y  AF+
Sbjct: 313 DIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFI 372

Query: 305 LEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERF 364
           LE  R  +  P   P    +DT ++G+ IPK+  V ++   ++ DP LW DP E +PERF
Sbjct: 373 LETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERF 432

Query: 365 IDEKGLSKS---NEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGV 416
           +   G + +   +E +  FG G+RRC G+ LA+  +F+    +LQ+       GV
Sbjct: 433 LTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGV 487



 Score = 31.9 bits (69), Expect = 4.6
 Identities = 22/76 (28%), Positives = 39/76 (51%), Gaps = 3/76 (3%)

Query: 62  ALLELSKQWSTQVLGLKLGRELVVVVYGEKNVRQ--VFSESEFDGRPNSFFYKLRCLGKR 119
           AL  +S+++   VL +++G   V+V+     +RQ  V    +F GRP+ +   L   G+ 
Sbjct: 64  ALSRMSQRYG-DVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQS 122

Query: 120 LGVTFVDGPLWREHRQ 135
           L  +   GP+W   R+
Sbjct: 123 LTFSTDSGPVWAARRR 138


>BC067427-1|AAH67427.1|  516|Homo sapiens cytochrome P450, family 1,
           subfamily A, polypeptide 2 protein.
          Length = 516

 Score =  111 bits (266), Expect = 6e-24
 Identities = 58/175 (33%), Positives = 94/175 (53%), Gaps = 4/175 (2%)

Query: 246 DLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSKLVYTSAFL 304
           D+  AG  T   A+ ++L+ ++    IQ KI  E++  IG +  P  +D  +L Y  AF+
Sbjct: 313 DIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFI 372

Query: 305 LEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERF 364
           LE  R  +  P   P    +DT ++G+ IPK+  V ++   ++ DP LW DP E +PERF
Sbjct: 373 LETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERF 432

Query: 365 IDEKGLSKS---NEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGV 416
           +   G + +   +E +  FG G+RRC G+ LA+  +F+    +LQ+       GV
Sbjct: 433 LTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGV 487


>BC067426-1|AAH67426.1|  516|Homo sapiens cytochrome P450, family 1,
           subfamily A, polypeptide 2 protein.
          Length = 516

 Score =  111 bits (266), Expect = 6e-24
 Identities = 58/175 (33%), Positives = 94/175 (53%), Gaps = 4/175 (2%)

Query: 246 DLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSKLVYTSAFL 304
           D+  AG  T   A+ ++L+ ++    IQ KI  E++  IG +  P  +D  +L Y  AF+
Sbjct: 313 DIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFI 372

Query: 305 LEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERF 364
           LE  R  +  P   P    +DT ++G+ IPK+  V ++   ++ DP LW DP E +PERF
Sbjct: 373 LETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERF 432

Query: 365 IDEKGLSKS---NEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGV 416
           +   G + +   +E +  FG G+RRC G+ LA+  +F+    +LQ+       GV
Sbjct: 433 LTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGV 487



 Score = 31.9 bits (69), Expect = 4.6
 Identities = 22/76 (28%), Positives = 39/76 (51%), Gaps = 3/76 (3%)

Query: 62  ALLELSKQWSTQVLGLKLGRELVVVVYGEKNVRQ--VFSESEFDGRPNSFFYKLRCLGKR 119
           AL  +S+++   VL +++G   V+V+     +RQ  V    +F GRP+ +   L   G+ 
Sbjct: 64  ALSRMSQRYG-DVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQS 122

Query: 120 LGVTFVDGPLWREHRQ 135
           L  +   GP+W   R+
Sbjct: 123 LTFSTDSGPVWAARRR 138


>BC067425-1|AAH67425.1|  516|Homo sapiens cytochrome P450, family 1,
           subfamily A, polypeptide 2 protein.
          Length = 516

 Score =  111 bits (266), Expect = 6e-24
 Identities = 58/175 (33%), Positives = 94/175 (53%), Gaps = 4/175 (2%)

Query: 246 DLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSKLVYTSAFL 304
           D+  AG  T   A+ ++L+ ++    IQ KI  E++  IG +  P  +D  +L Y  AF+
Sbjct: 313 DIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFI 372

Query: 305 LEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERF 364
           LE  R  +  P   P    +DT ++G+ IPK+  V ++   ++ DP LW DP E +PERF
Sbjct: 373 LETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERF 432

Query: 365 IDEKGLSKS---NEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGV 416
           +   G + +   +E +  FG G+RRC G+ LA+  +F+    +LQ+       GV
Sbjct: 433 LTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGV 487



 Score = 31.9 bits (69), Expect = 4.6
 Identities = 22/76 (28%), Positives = 39/76 (51%), Gaps = 3/76 (3%)

Query: 62  ALLELSKQWSTQVLGLKLGRELVVVVYGEKNVRQ--VFSESEFDGRPNSFFYKLRCLGKR 119
           AL  +S+++   VL +++G   V+V+     +RQ  V    +F GRP+ +   L   G+ 
Sbjct: 64  ALSRMSQRYG-DVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQS 122

Query: 120 LGVTFVDGPLWREHRQ 135
           L  +   GP+W   R+
Sbjct: 123 LTFSTDSGPVWAARRR 138


>BC067424-1|AAH67424.1|  516|Homo sapiens cytochrome P450, family 1,
           subfamily A, polypeptide 2 protein.
          Length = 516

 Score =  111 bits (266), Expect = 6e-24
 Identities = 58/175 (33%), Positives = 94/175 (53%), Gaps = 4/175 (2%)

Query: 246 DLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSKLVYTSAFL 304
           D+  AG  T   A+ ++L+ ++    IQ KI  E++  IG +  P  +D  +L Y  AF+
Sbjct: 313 DIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFI 372

Query: 305 LEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERF 364
           LE  R  +  P   P    +DT ++G+ IPK+  V ++   ++ DP LW DP E +PERF
Sbjct: 373 LETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERF 432

Query: 365 IDEKGLSKS---NEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGV 416
           +   G + +   +E +  FG G+RRC G+ LA+  +F+    +LQ+       GV
Sbjct: 433 LTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGV 487



 Score = 31.9 bits (69), Expect = 4.6
 Identities = 22/76 (28%), Positives = 39/76 (51%), Gaps = 3/76 (3%)

Query: 62  ALLELSKQWSTQVLGLKLGRELVVVVYGEKNVRQ--VFSESEFDGRPNSFFYKLRCLGKR 119
           AL  +S+++   VL +++G   V+V+     +RQ  V    +F GRP+ +   L   G+ 
Sbjct: 64  ALSRMSQRYG-DVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQS 122

Query: 120 LGVTFVDGPLWREHRQ 135
           L  +   GP+W   R+
Sbjct: 123 LTFSTDSGPVWAARRR 138


>AF253322-2|AAK25728.1|  516|Homo sapiens cytochrome P450 protein.
          Length = 516

 Score =  111 bits (266), Expect = 6e-24
 Identities = 58/175 (33%), Positives = 94/175 (53%), Gaps = 4/175 (2%)

Query: 246 DLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSKLVYTSAFL 304
           D+  AG  T   A+ ++L+ ++    IQ KI  E++  IG +  P  +D  +L Y  AF+
Sbjct: 313 DIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFI 372

Query: 305 LEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERF 364
           LE  R  +  P   P    +DT ++G+ IPK+  V ++   ++ DP LW DP E +PERF
Sbjct: 373 LETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERF 432

Query: 365 IDEKGLSKS---NEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGV 416
           +   G + +   +E +  FG G+RRC G+ LA+  +F+    +LQ+       GV
Sbjct: 433 LTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGV 487



 Score = 31.9 bits (69), Expect = 4.6
 Identities = 22/76 (28%), Positives = 39/76 (51%), Gaps = 3/76 (3%)

Query: 62  ALLELSKQWSTQVLGLKLGRELVVVVYGEKNVRQ--VFSESEFDGRPNSFFYKLRCLGKR 119
           AL  +S+++   VL +++G   V+V+     +RQ  V    +F GRP+ +   L   G+ 
Sbjct: 64  ALSRMSQRYG-DVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQS 122

Query: 120 LGVTFVDGPLWREHRQ 135
           L  +   GP+W   R+
Sbjct: 123 LTFSTDSGPVWAARRR 138


>AM183950-1|CAJ75804.1|  494|Homo sapiens steroid 21-hydroxylase,
           CYP21 protein.
          Length = 494

 Score =  110 bits (265), Expect = 8e-24
 Identities = 60/188 (31%), Positives = 102/188 (54%), Gaps = 8/188 (4%)

Query: 236 LNDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG----DSMPCW 291
           L   +    +DL+I G++TT N + +A++ +L +  IQ+++  E+++ +G     S   +
Sbjct: 277 LEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPY 336

Query: 292 ADSSKLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPN 351
            D ++L   +A + EV+R+  + PLA P    + + I GY IP+ T ++ +L   HLD  
Sbjct: 337 KDRARLPLLNATIAEVLRLRPVVPLALPHCTTRPSSISGYDIPEGTVIIPNLQGAHLDET 396

Query: 352 LWPDPHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRID 411
           +W  PHE  P+RF+ E G    N     FG G R C G+ LAR  +F++   +LQ + + 
Sbjct: 397 VWERPHEFWPDRFL-EPG---KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLL 452

Query: 412 CVNGVLPS 419
                LPS
Sbjct: 453 PSGDALPS 460


>AF182274-1|AAF13599.1|  516|Homo sapiens cytochrome P450-1A2
           protein.
          Length = 516

 Score =  110 bits (265), Expect = 8e-24
 Identities = 58/175 (33%), Positives = 94/175 (53%), Gaps = 4/175 (2%)

Query: 246 DLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSKLVYTSAFL 304
           D+  AG  T   A+ ++L+ ++    IQ KI  E++  IG +  P  +D  +L Y  AF+
Sbjct: 313 DVFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFI 372

Query: 305 LEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERF 364
           LE  R  +  P   P    +DT ++G+ IPK+  V ++   ++ DP LW DP E +PERF
Sbjct: 373 LETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERF 432

Query: 365 IDEKGLSKS---NEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGV 416
           +   G + +   +E +  FG G+RRC G+ LA+  +F+    +LQ+       GV
Sbjct: 433 LTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGV 487



 Score = 31.9 bits (69), Expect = 4.6
 Identities = 22/76 (28%), Positives = 39/76 (51%), Gaps = 3/76 (3%)

Query: 62  ALLELSKQWSTQVLGLKLGRELVVVVYGEKNVRQ--VFSESEFDGRPNSFFYKLRCLGKR 119
           AL  +S+++   VL +++G   V+V+     +RQ  V    +F GRP+ +   L   G+ 
Sbjct: 64  ALSRMSQRYG-DVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQS 122

Query: 120 LGVTFVDGPLWREHRQ 135
           L  +   GP+W   R+
Sbjct: 123 LTFSTDSGPVWAARRR 138


>BC067429-1|AAH67429.1|  516|Homo sapiens cytochrome P450, family 1,
           subfamily A, polypeptide 2 protein.
          Length = 516

 Score =  110 bits (264), Expect = 1e-23
 Identities = 58/175 (33%), Positives = 93/175 (53%), Gaps = 4/175 (2%)

Query: 246 DLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSKLVYTSAFL 304
           D+  AG  T   A+ ++L+ ++    IQ KI  E++  IG +  P  +D  +L Y  AF+
Sbjct: 313 DIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFI 372

Query: 305 LEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERF 364
           LE  R     P   P    +DT ++G+ IPK+  V ++   ++ DP LW DP E +PERF
Sbjct: 373 LETFRHSPFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERF 432

Query: 365 IDEKGLSKS---NEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGV 416
           +   G + +   +E +  FG G+RRC G+ LA+  +F+    +LQ+       GV
Sbjct: 433 LTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGV 487



 Score = 31.9 bits (69), Expect = 4.6
 Identities = 22/76 (28%), Positives = 39/76 (51%), Gaps = 3/76 (3%)

Query: 62  ALLELSKQWSTQVLGLKLGRELVVVVYGEKNVRQ--VFSESEFDGRPNSFFYKLRCLGKR 119
           AL  +S+++   VL +++G   V+V+     +RQ  V    +F GRP+ +   L   G+ 
Sbjct: 64  ALSRMSQRYG-DVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQS 122

Query: 120 LGVTFVDGPLWREHRQ 135
           L  +   GP+W   R+
Sbjct: 123 LTFSTDSGPVWAARRR 138


>M12079-1|AAA52152.1|  191|Homo sapiens POR protein.
          Length = 191

 Score =  109 bits (263), Expect = 1e-23
 Identities = 60/174 (34%), Positives = 96/174 (55%), Gaps = 3/174 (1%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSM-PCWADSS 295
           ++++  + LDL  AG  T   A+ ++L+ ++ N  +Q KI  E++  IG S  P  +D S
Sbjct: 10  DEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRS 69

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
            L Y  AF+LE  R  +  P   P    +DT + G+ IPK   V ++   I+ D  LW +
Sbjct: 70  HLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVN 129

Query: 356 PHEIKPERFIDEKG-LSK-SNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQK 407
           P E  PERF+   G + K  +E +  FG G+R+C G+++AR  VF+    +LQ+
Sbjct: 130 PSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETVARWEVFLFLAILLQR 183


>AK223108-1|BAD96828.1|  512|Homo sapiens cytochrome P450, family 1,
           subfamily A, polypeptide 1 variant protein.
          Length = 512

 Score =  109 bits (262), Expect = 2e-23
 Identities = 62/183 (33%), Positives = 96/183 (52%), Gaps = 3/183 (1%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSM-PCWADSS 295
           ++++  + LDL  AG  T   A  ++L+ ++ N  +Q KI  E++  IG S  P  +D S
Sbjct: 304 DEKIINIVLDLFGAGFDTVTTATSWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRS 363

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
            L Y  AF+LE  R  +  P   P    +DT + G+ IPK   V ++   I  D  LW +
Sbjct: 364 HLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQIDHDQKLWVN 423

Query: 356 PHEIKPERFIDEKG-LSK-SNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCV 413
           P E  PERF+   G + K  +E +  FG G+R+C G+++AR  VF+    +LQ+      
Sbjct: 424 PSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVP 483

Query: 414 NGV 416
            GV
Sbjct: 484 LGV 486



 Score = 42.7 bits (96), Expect = 0.002
 Identities = 32/111 (28%), Positives = 53/111 (47%), Gaps = 9/111 (8%)

Query: 35  PGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKNVR 94
           PGP  +P  G       M +   +   AL  +S+Q+   VL +++G   VVV+ G   +R
Sbjct: 41  PGPWDWPLIG------HMLTLGKNPHLALSRMSQQYG-DVLQIRIGSTPVVVLSGLDTIR 93

Query: 95  Q--VFSESEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKN 143
           Q  V    +F GRP+ + + L   G+ +  +   GP+W   R+     LK+
Sbjct: 94  QALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKS 144


>L16876-1|AAA02630.1|  490|Homo sapiens cytochrome P-4502C18
           protein.
          Length = 490

 Score =  109 bits (261), Expect = 3e-23
 Identities = 54/174 (31%), Positives = 90/174 (51%), Gaps = 1/174 (0%)

Query: 238 DQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSK 296
           + L     D+  AG++TT   +++ LL +L+   +  K+  EIE  +G +  PC  D S 
Sbjct: 285 ESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSH 344

Query: 297 LVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDP 356
           + YT A + E+ R   + P   P  V  D     Y+IPK  T++ SL  +  +   +P+P
Sbjct: 345 MPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGMTIITSLTSVLHNDKEFPNP 404

Query: 357 HEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRI 410
               P  F+D+ G  K +++  PF +G+R C G+ LAR  +F+    ILQ + +
Sbjct: 405 EMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNL 458



 Score = 63.3 bits (147), Expect = 2e-09
 Identities = 50/178 (28%), Positives = 84/178 (47%), Gaps = 12/178 (6%)

Query: 36  GPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKNVRQ 95
           GP   P  G+   + Q+  K  S  K+L   SK +   V  +  G + +VV++G + V++
Sbjct: 32  GPTPLPIIGN---ILQLDVKDMS--KSLTNFSKVYGP-VFTVYFGLKPIVVLHGYEAVKE 85

Query: 96  VFSE--SEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTSMEL 153
              +   EF GR +  F     + K LG+ F +G  W+E R+F +  L+N G GK S+E 
Sbjct: 86  ALIDHGEEFSGRGS--FPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIED 143

Query: 154 EIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERI--REDKLERLLELF 209
            +Q E + L E +      P     +   A  NV+   +  +R   ++ +   L+E F
Sbjct: 144 RVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKF 201


>U22029-1|AAB40520.1|  494|Homo sapiens cytochrome P450 protein.
          Length = 494

 Score =  108 bits (260), Expect = 3e-23
 Identities = 50/167 (29%), Positives = 91/167 (54%), Gaps = 1/167 (0%)

Query: 245 LDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDS-MPCWADSSKLVYTSAF 303
           L+L IAG++T    +++  L ++++  ++ K+  EI+  IG +  P + D +K+ Y  A 
Sbjct: 296 LNLFIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAV 355

Query: 304 LLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPER 363
           + E+ R   + P++  RRV +DT    + +PK T V   L  +  D   + +P +  P+ 
Sbjct: 356 IHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDLRFFSNPRDFNPQH 415

Query: 364 FIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRI 410
           F+ EKG  K  +   PF   +R C G+ LAR  +F+ F  ++Q +R+
Sbjct: 416 FLGEKGQFKKRDAFVPFSIRKRNCFGEGLARMELFLFFTTVMQNFRL 462



 Score = 56.8 bits (131), Expect = 1e-07
 Identities = 63/223 (28%), Positives = 95/223 (42%), Gaps = 19/223 (8%)

Query: 33  MAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKN 92
           + PGP   PF G+     Q+ ++H     ++++ S+ +   V  + LG   VVV+ G   
Sbjct: 33  LPPGPTPLPFIGN---YLQLNTEHICD--SIMKFSECYGP-VFTIHLGPRRVVVLCGHDA 86

Query: 93  VRQVFSES--EFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTS 150
           VR+   +   EF GR     ++   + K  GV F +G   ++  +F +  L++ G GK  
Sbjct: 87  VREALVDQAEEFSGRGEQATFEW--VFKGYGVAFSNGERAKQLLRFAIATLRDFGVGKRG 144

Query: 151 MELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERI-REDK-----LER 204
           +E  IQ E   L E I       I      S  V NV+   V G+R   EDK     L  
Sbjct: 145 IEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLSM 204

Query: 205 LLELFYLRSKAFTLTGGLLSKIPWCRFIIPGLNDQLKTVCLDL 247
           +L +F   S   T TG L          +PG   Q   + L L
Sbjct: 205 MLGIFQFTS---TSTGQLYEMFSSLMKHLPGPQQQAFKLLLGL 244


>U22027-1|AAB40518.1|  494|Homo sapiens cytochrome P450 protein.
          Length = 494

 Score =  107 bits (257), Expect = 8e-23
 Identities = 53/199 (26%), Positives = 100/199 (50%), Gaps = 3/199 (1%)

Query: 245 LDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDS-MPCWADSSKLVYTSAF 303
           L+L IAG++T    + +  L ++++  ++ K+  EI+  IG +  P + D +K+ Y  A 
Sbjct: 296 LNLFIAGTETVSTTLHYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAV 355

Query: 304 LLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPER 363
           + E+ R   + P++  RRV +DT    + +PK   V   L  +  D   + +P +  P+ 
Sbjct: 356 IHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGIEVFPMLGSVLRDLRFFSNPRDFNPQH 415

Query: 364 FIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGV--LPSNE 421
           F+ EKG  K  +   PF   +R C G+ LAR  +F+ F  ++Q +R+        +  + 
Sbjct: 416 FLGEKGQFKKRDAFVPFSIRKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSP 475

Query: 422 ADIGLLAAPKPFVANFVSR 440
             +G    P+ +  +F+ R
Sbjct: 476 KHVGFATIPRNYTMSFLPR 494



 Score = 57.2 bits (132), Expect = 1e-07
 Identities = 53/189 (28%), Positives = 84/189 (44%), Gaps = 11/189 (5%)

Query: 33  MAPGPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKN 92
           + PGP   PF G+   +Q  T +    + +L+++S+++   V  + LG   VVV+ G   
Sbjct: 33  LPPGPTPLPFIGN--YLQLNTEQ---MYNSLMKISERYGP-VFTIHLGPRRVVVLCGHDA 86

Query: 93  VRQVFSES--EFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTS 150
           VR+   +   EF GR     +    + K  GV F +G   ++  +F +  L++ G GK  
Sbjct: 87  VREALVDQAEEFSGRGEQATFDW--VFKGYGVVFSNGERAKQLLRFAIATLRDFGVGKRG 144

Query: 151 MELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERIREDKLERLLELFY 210
           +E  IQ E   L E I       I      S  V NV+   V G+R  + K +  L L  
Sbjct: 145 IEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFGDRF-DYKDKEFLSLLR 203

Query: 211 LRSKAFTLT 219
           +    F  T
Sbjct: 204 MMLGIFQFT 212


>K03192-1|AAA52147.1|  331|Homo sapiens CYP1A1 protein.
          Length = 331

 Score =  106 bits (255), Expect = 1e-22
 Identities = 53/206 (25%), Positives = 102/206 (49%), Gaps = 3/206 (1%)

Query: 238 DQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDS-MPCWADSSK 296
           ++L    L+L I G++T    +++  L ++++  ++ K+  EI+  IG +  P + D +K
Sbjct: 126 EKLVMTSLNLFIGGTETVSTTLRYGFLLLIKHPGVEAKVHEEIDRVIGKNRQPKFEDRAK 185

Query: 297 LVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDP 356
           + Y  A + E+ R   + P+  P RV +DT    + +PK T V   L  +  DP     P
Sbjct: 186 MPYMEAMIHEIQRFGDVIPMIWPGRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPIFLSKP 245

Query: 357 HEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGV 416
            +  P+ F + +G  K ++   PF  G+  C G+ LAR  +F+ F  ++Q +R+      
Sbjct: 246 QDFNPQHFTELEGAPKKSDAFVPFSIGQPNCFGEGLARMELFLFFTTVMQNFRLKSSQSP 305

Query: 417 --LPSNEADIGLLAAPKPFVANFVSR 440
             +  +   +G    P+ +  +F+ R
Sbjct: 306 KDIDVSPKHVGFPRFPRNYTMSFLPR 331


>M12078-1|AAA52154.1|  192|Homo sapiens POR protein.
          Length = 192

 Score =  105 bits (252), Expect = 3e-22
 Identities = 56/167 (33%), Positives = 92/167 (55%), Gaps = 5/167 (2%)

Query: 246 DLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSKLVYTSAFL 304
           D+  AG  T   A+ ++L+ ++    IQ KI  E++  IG +  P  +D  +L Y  AF+
Sbjct: 19  DIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFI 78

Query: 305 LEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERF 364
           LE  R  +  P   P    +DT ++G+ IPK+  V ++   ++ DP LW DP E +PERF
Sbjct: 79  LETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERF 138

Query: 365 I--DEKGLSK--SNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQK 407
           +  D   ++K  S + +   G G+RRC G+ LA+  +F+    +LQ+
Sbjct: 139 LTADGTAINKPLSEKMMMLVGMGKRRCIGEVLAKWEIFLFLAILLQQ 185


>AB209700-1|BAD92937.1|  336|Homo sapiens cytochrome P450, family 2,
           subfamily E, polypeptide 1 variant protein.
          Length = 336

 Score =  105 bits (251), Expect = 4e-22
 Identities = 50/147 (34%), Positives = 82/147 (55%), Gaps = 1/147 (0%)

Query: 238 DQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDS-MPCWADSSK 296
           D +     DL  AG++TT   +++ LL +++   I+EK+  EI+  IG S +P   D  +
Sbjct: 183 DGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQE 242

Query: 297 LVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDP 356
           + Y  A + E+ R  T+ P   P    +DT+  GY+IPK T V+ +L  +  D   +PDP
Sbjct: 243 MPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDP 302

Query: 357 HEIKPERFIDEKGLSKSNEHIYPFGSG 383
            + KPE F++E G  K +++  PF +G
Sbjct: 303 EKFKPEHFLNENGKFKYSDYFKPFSTG 329


>L16883-1|AAD13467.1|  169|Homo sapiens cytochrome P-450 2C protein.
          Length = 169

 Score = 99.1 bits (236), Expect = 3e-20
 Identities = 51/137 (37%), Positives = 74/137 (54%), Gaps = 1/137 (0%)

Query: 275 KIFNEIENTIG-DSMPCWADSSKLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVI 333
           K+  EIE  IG +  PC  D S + YT A + EV R   + P + P  V  D     Y+I
Sbjct: 1   KVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYLDLLPTSLPHAVTCDIKFRNYLI 60

Query: 334 PKETTVLISLADIHLDPNLWPDPHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLA 393
           PK TT+LISL  +  D   +P+P    P  F+DE G  K +++  PF +G+R C G++LA
Sbjct: 61  PKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALA 120

Query: 394 RSFVFIIFVGILQKYRI 410
              +F+    ILQ + +
Sbjct: 121 GMELFLFLTSILQNFNL 137


>DQ016495-1|AAY34975.1|  195|Homo sapiens cytochrome P450 1B1
           protein.
          Length = 195

 Score = 99.1 bits (236), Expect = 3e-20
 Identities = 56/175 (32%), Positives = 86/175 (49%), Gaps = 5/175 (2%)

Query: 271 NIQEKIFNEIENTIG-DSMPCWADSSKLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVID 329
           ++Q ++  E++  +G D +PC  D   L Y  AFL E MR  +  P+        +T + 
Sbjct: 3   DVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTISHATTANTSVL 62

Query: 330 GYVIPKETTVLISLADIHLDPNLWPDPHEIKPERFIDEKGLSKSN--EHIYPFGSGRRRC 387
           GY IPK+T V ++   ++ DP  WP+P    P RF+D+ GL   +    +  F  G+RRC
Sbjct: 63  GYHIPKDTVVFVNQWSVNHDPLKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRC 122

Query: 388 PGDSLARSFVFIIFVGILQKYRIDCVNGVLPSN-EADIGLLAAPKPFVANFVSRE 441
            G+ L++  +F +F+ IL        N   P+      GL   PK F  N   RE
Sbjct: 123 IGEELSKMQLF-LFISILAHQCDFRANPNEPAKMNFSYGLTIKPKSFKVNVTLRE 176


>AY220845-1|AAO49806.1|  516|Homo sapiens cytochrome P450 protein.
          Length = 516

 Score = 98.3 bits (234), Expect = 5e-20
 Identities = 52/161 (32%), Positives = 79/161 (49%), Gaps = 2/161 (1%)

Query: 275 KIFNEIENTIGD-SMPCWADSSKLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVI 333
           ++  EI++ IG    P   D   + YT+A + EV R   I PL       +D  + G+ I
Sbjct: 349 RVQQEIDDVIGQVRRPEMGDQVHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRI 408

Query: 334 PKETTVLISLADIHLDPNLWPDPHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLA 393
           PK TT++ +L+ +  D  +W  P    PE F+D +G     E   PF +GRR C G+ LA
Sbjct: 409 PKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLA 468

Query: 394 RSFVFIIFVGILQKYRIDCVNG-VLPSNEADIGLLAAPKPF 433
           R  +F+ F  +LQ +      G   PS+   +  L  P P+
Sbjct: 469 RMELFLFFTSLLQHFSFSVAAGQPRPSHSRVVSFLVTPSPY 509



 Score = 64.5 bits (150), Expect = 7e-10
 Identities = 47/157 (29%), Positives = 68/157 (43%), Gaps = 5/157 (3%)

Query: 74  VLGLKLGRELVVVVYGEKNVRQVFSESEFD--GRPNSFFYKLRCLGKRLGVTFVD--GPL 129
           V  L+L    VVV+ G   VR+       D   RP +  Y++   G R     +   GP 
Sbjct: 68  VFNLQLAWTPVVVLNGLAAVREAMVTRGEDTADRPPAPIYQVLGFGPRSQGVILSRYGPA 127

Query: 130 WREHRQFTVKHLKNVGFGKTSMELEIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLW 189
           WRE R+F+V  L+N+G GK S+E  +  E   L     D   +P + + +   AV NV+ 
Sbjct: 128 WREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFADQAGRPFRPNGLLDKAVSNVIA 187

Query: 190 KYVAGERIREDKLERLLELFYLRSKAFTLTGGLLSKI 226
               G R   D   R L L  L  +      G L ++
Sbjct: 188 SLTCGRRFEYDD-PRFLRLLDLAQEGLKEESGFLREV 223


>AK223008-1|BAD96728.1|  502|Homo sapiens cytochrome P450, family 3,
           subfamily A, polypeptide 5 variant protein.
          Length = 502

 Score = 94.7 bits (225), Expect = 6e-19
 Identities = 60/206 (29%), Positives = 101/206 (49%), Gaps = 6/206 (2%)

Query: 239 QLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPCWADSS-KL 297
           +L    +  I AG +TT + + F L  +  + ++Q+K+  EI+  + +  P   D+  ++
Sbjct: 294 ELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQM 353

Query: 298 VYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPH 357
            Y    + E +R+  +A +   R  ++D  I+G  IPK + V+I    +H DP  W +P 
Sbjct: 354 EYLDMVVNETLRLFPVA-IRLERTCMKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPE 412

Query: 358 EIKPERFIDEKGLSKSNEHIY-PFGSGRRRCPGDSLARSFVFIIFVGILQKYRI-DCVNG 415
           E +PERF  +K     + +IY PFG+G R C G   A   + +  + +LQ +    C   
Sbjct: 413 EFRPERFSKKK--DSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKET 470

Query: 416 VLPSNEADIGLLAAPKPFVANFVSRE 441
            +P      GLL   KP V    SR+
Sbjct: 471 QIPLKLDTQGLLQPEKPIVLKVDSRD 496


>J04813-1|AAA02993.1|  502|Homo sapiens cytochrome P450 PCN3
           protein.
          Length = 502

 Score = 93.1 bits (221), Expect = 2e-18
 Identities = 60/206 (29%), Positives = 100/206 (48%), Gaps = 6/206 (2%)

Query: 239 QLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPCWADSS-KL 297
           +L    +  I AG +TT + + F L  +  + ++Q+K+  EI+  + +  P   D+  ++
Sbjct: 294 ELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQM 353

Query: 298 VYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPH 357
            Y    + E +R+  +A +   R   +D  I+G  IPK + V+I    +H DP  W +P 
Sbjct: 354 EYLDMVVNETLRLFPVA-IRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPE 412

Query: 358 EIKPERFIDEKGLSKSNEHIY-PFGSGRRRCPGDSLARSFVFIIFVGILQKYRI-DCVNG 415
           E +PERF  +K     + +IY PFG+G R C G   A   + +  + +LQ +    C   
Sbjct: 413 EFRPERFSKKK--DSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKET 470

Query: 416 VLPSNEADIGLLAAPKPFVANFVSRE 441
            +P      GLL   KP V    SR+
Sbjct: 471 QIPLKLDTQGLLQPEKPIVLKVDSRD 496


>BC033862-1|AAH33862.1|  502|Homo sapiens cytochrome P450, family 3,
           subfamily A, polypeptide 5 protein.
          Length = 502

 Score = 93.1 bits (221), Expect = 2e-18
 Identities = 60/206 (29%), Positives = 100/206 (48%), Gaps = 6/206 (2%)

Query: 239 QLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPCWADSS-KL 297
           +L    +  I AG +TT + + F L  +  + ++Q+K+  EI+  + +  P   D+  ++
Sbjct: 294 ELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQM 353

Query: 298 VYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPH 357
            Y    + E +R+  +A +   R   +D  I+G  IPK + V+I    +H DP  W +P 
Sbjct: 354 EYLDMVVNETLRLFPVA-IRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPE 412

Query: 358 EIKPERFIDEKGLSKSNEHIY-PFGSGRRRCPGDSLARSFVFIIFVGILQKYRI-DCVNG 415
           E +PERF  +K     + +IY PFG+G R C G   A   + +  + +LQ +    C   
Sbjct: 413 EFRPERFSKKK--DSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKET 470

Query: 416 VLPSNEADIGLLAAPKPFVANFVSRE 441
            +P      GLL   KP V    SR+
Sbjct: 471 QIPLKLDTQGLLQPEKPIVLKVDSRD 496


>AC005020-1|AAS02016.1|  502|Homo sapiens unknown protein.
          Length = 502

 Score = 93.1 bits (221), Expect = 2e-18
 Identities = 60/206 (29%), Positives = 100/206 (48%), Gaps = 6/206 (2%)

Query: 239 QLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPCWADSS-KL 297
           +L    +  I AG +TT + + F L  +  + ++Q+K+  EI+  + +  P   D+  ++
Sbjct: 294 ELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQM 353

Query: 298 VYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPH 357
            Y    + E +R+  +A +   R   +D  I+G  IPK + V+I    +H DP  W +P 
Sbjct: 354 EYLDMVVNETLRLFPVA-IRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPE 412

Query: 358 EIKPERFIDEKGLSKSNEHIY-PFGSGRRRCPGDSLARSFVFIIFVGILQKYRI-DCVNG 415
           E +PERF  +K     + +IY PFG+G R C G   A   + +  + +LQ +    C   
Sbjct: 413 EFRPERFSKKK--DSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKET 470

Query: 416 VLPSNEADIGLLAAPKPFVANFVSRE 441
            +P      GLL   KP V    SR+
Sbjct: 471 QIPLKLDTQGLLQPEKPIVLKVDSRD 496


>D00408-1|BAA00310.1|  503|Homo sapiens cytochrome P-450 HFLa
           protein.
          Length = 503

 Score = 91.5 bits (217), Expect = 5e-18
 Identities = 61/206 (29%), Positives = 98/206 (47%), Gaps = 5/206 (2%)

Query: 239 QLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPCWADSS-KL 297
           +L    +  I AG +TT + + F +  +  + ++Q+K+  EI+  + +  P   D+  +L
Sbjct: 294 ELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQL 353

Query: 298 VYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPH 357
            Y    + E +R+  +A +   R   +D  I+G  IPK   V+I    +H DP  W +P 
Sbjct: 354 EYLDMVVNETLRLFPVA-MRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPE 412

Query: 358 EIKPERFIDEKGLSKSNEHIY-PFGSGRRRCPGDSLARSFVFIIFVGILQKYRI-DCVNG 415
           +  PERF  +K     + +IY PFGSG R C G   A   + +  V +LQ +    C   
Sbjct: 413 KFLPERF-SKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKET 471

Query: 416 VLPSNEADIGLLAAPKPFVANFVSRE 441
            +P      GLL   KP V    SR+
Sbjct: 472 QIPLKLRFGGLLLTEKPIVLKAESRD 497


>BC096259-1|AAH96259.1|  443|Homo sapiens CYP2C18 protein protein.
          Length = 443

 Score = 91.5 bits (217), Expect = 5e-18
 Identities = 46/149 (30%), Positives = 76/149 (51%), Gaps = 1/149 (0%)

Query: 238 DQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIG-DSMPCWADSSK 296
           + L     D+  AG++TT   +++ LL +L+   +  K+  EIE  +G +  PC  D S 
Sbjct: 285 ESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSH 344

Query: 297 LVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDP 356
           + YT A + E+ R   + P   P  V  D     Y+IPK TT++ SL  +  +   +P+P
Sbjct: 345 MPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNP 404

Query: 357 HEIKPERFIDEKGLSKSNEHIYPFGSGRR 385
               P  F+D+ G  K +++  PF +G R
Sbjct: 405 EMFDPGHFLDKSGNFKKSDYFMPFSAGNR 433



 Score = 63.3 bits (147), Expect = 2e-09
 Identities = 50/178 (28%), Positives = 84/178 (47%), Gaps = 12/178 (6%)

Query: 36  GPIWYPFFGSSSIVQQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKNVRQ 95
           GP   P  G+   + Q+  K  S  K+L   SK +   V  +  G + +VV++G + V++
Sbjct: 32  GPTPLPIIGN---ILQLDVKDMS--KSLTNFSKVYGP-VFTVYFGLKPIVVLHGYEAVKE 85

Query: 96  VFSE--SEFDGRPNSFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTSMEL 153
              +   EF GR +  F     + K LG+ F +G  W+E R+F +  L+N G GK S+E 
Sbjct: 86  ALIDHGEEFSGRGS--FPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIED 143

Query: 154 EIQNELKLLREYINDNKHKPIKVDSMFSSAVMNVLWKYVAGERI--REDKLERLLELF 209
            +Q E + L E +      P     +   A  NV+   +  +R   ++ +   L+E F
Sbjct: 144 RVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKF 201


>BC067436-1|AAH67436.1|  503|Homo sapiens cytochrome P450, family 3,
           subfamily A, polypeptide 7 protein.
          Length = 503

 Score = 91.5 bits (217), Expect = 5e-18
 Identities = 61/206 (29%), Positives = 98/206 (47%), Gaps = 5/206 (2%)

Query: 239 QLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPCWADSS-KL 297
           +L    +  I AG +TT + + F +  +  + ++Q+K+  EI+  + +  P   D+  +L
Sbjct: 294 ELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQL 353

Query: 298 VYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPH 357
            Y    + E +R+  +A +   R   +D  I+G  IPK   V+I    +H DP  W +P 
Sbjct: 354 EYLDMVVNETLRLFPVA-MRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPE 412

Query: 358 EIKPERFIDEKGLSKSNEHIY-PFGSGRRRCPGDSLARSFVFIIFVGILQKYRI-DCVNG 415
           +  PERF  +K     + +IY PFGSG R C G   A   + +  V +LQ +    C   
Sbjct: 413 KFLPERF-SKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKET 471

Query: 416 VLPSNEADIGLLAAPKPFVANFVSRE 441
            +P      GLL   KP V    SR+
Sbjct: 472 QIPLKLRFGGLLLTEKPIVLKAESRD 497


>AF315325-1|AAG48618.1|  535|Homo sapiens cytochrome P450 variant
           3A7 protein.
          Length = 535

 Score = 91.5 bits (217), Expect = 5e-18
 Identities = 61/206 (29%), Positives = 98/206 (47%), Gaps = 5/206 (2%)

Query: 239 QLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPCWADSS-KL 297
           +L    +  I AG +TT + + F +  +  + ++Q+K+  EI+  + +  P   D+  +L
Sbjct: 294 ELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQL 353

Query: 298 VYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPH 357
            Y    + E +R+  +A +   R   +D  I+G  IPK   V+I    +H DP  W +P 
Sbjct: 354 EYLDMVVNETLRLFPVA-MRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPE 412

Query: 358 EIKPERFIDEKGLSKSNEHIY-PFGSGRRRCPGDSLARSFVFIIFVGILQKYRI-DCVNG 415
           +  PERF  +K     + +IY PFGSG R C G   A   + +  V +LQ +    C   
Sbjct: 413 KFLPERF-SKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKET 471

Query: 416 VLPSNEADIGLLAAPKPFVANFVSRE 441
            +P      GLL   KP V    SR+
Sbjct: 472 QIPLKLRFGGLLLTEKPIVLKAESRD 497


>AF280107-3|AAG32289.1|  503|Homo sapiens cytochrome P450
           polypeptide 7 protein.
          Length = 503

 Score = 91.5 bits (217), Expect = 5e-18
 Identities = 61/206 (29%), Positives = 98/206 (47%), Gaps = 5/206 (2%)

Query: 239 QLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPCWADSS-KL 297
           +L    +  I AG +TT + + F +  +  + ++Q+K+  EI+  + +  P   D+  +L
Sbjct: 294 ELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQL 353

Query: 298 VYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPH 357
            Y    + E +R+  +A +   R   +D  I+G  IPK   V+I    +H DP  W +P 
Sbjct: 354 EYLDMVVNETLRLFPVA-MRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPE 412

Query: 358 EIKPERFIDEKGLSKSNEHIY-PFGSGRRRCPGDSLARSFVFIIFVGILQKYRI-DCVNG 415
           +  PERF  +K     + +IY PFGSG R C G   A   + +  V +LQ +    C   
Sbjct: 413 KFLPERF-SKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKET 471

Query: 416 VLPSNEADIGLLAAPKPFVANFVSRE 441
            +P      GLL   KP V    SR+
Sbjct: 472 QIPLKLRFGGLLLTEKPIVLKAESRD 497


>BC039307-1|AAH39307.1|  372|Homo sapiens FLJ16008 protein protein.
          Length = 372

 Score = 91.1 bits (216), Expect = 7e-18
 Identities = 66/242 (27%), Positives = 118/242 (48%), Gaps = 10/242 (4%)

Query: 204 RLLELFYLRSKAFTLTGGLLSKIPWCRFIIPGLN-DQLKTVCLDLIIAGSQTTGNAVKFA 262
           +L ++ Y   +   ++GGLL+ +    F+   L   ++     ++++AG  TT   + + 
Sbjct: 137 KLRDIQYQMDRGRRVSGGLLTYL----FLSQALTLQEIYANVTEMLLAGVDTTSFTLSWT 192

Query: 263 LLSVLRNKNIQEKIFNEIENTIGDS-MPCWADSSKLVYTSAFLLEVMRIHTIAPLAGPRR 321
           +  + R+  +Q+ ++ EI   +G+  +P  AD  K+    A L E +R+  + P  G R 
Sbjct: 193 VYILARHPEVQQTVYREIVKNLGERHVPTAADVPKVPLVRALLKETLRLFPVLPGNG-RV 251

Query: 322 VLQDTVIDGYVIPKETTV-LISLADIHLDPNLWPDPHEIKPERFIDEKGLSK-SNEHIYP 379
             +D VI GY+IPK T + L   A  + D N +P   E +PER++ +  L +  N    P
Sbjct: 252 TQEDLVIGGYLIPKGTQLALCHYATSYQDEN-FPRAKEFRPERWLRKGDLDRVDNFGSIP 310

Query: 380 FGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGVLPSNEADIGLLAAPKPFVANFVS 439
           FG G R C G  +A   + ++ + +LQ + I   +     +    GLL    P    FV+
Sbjct: 311 FGHGVRSCIGRRIAELEIHLVVIQLLQHFEIKTSSQTNAVHAKTHGLLTPGGPIHVRFVN 370

Query: 440 RE 441
           R+
Sbjct: 371 RK 372


>AK131190-1|BAD18388.1|  372|Homo sapiens .-.-).  protein.
          Length = 372

 Score = 91.1 bits (216), Expect = 7e-18
 Identities = 66/242 (27%), Positives = 118/242 (48%), Gaps = 10/242 (4%)

Query: 204 RLLELFYLRSKAFTLTGGLLSKIPWCRFIIPGLN-DQLKTVCLDLIIAGSQTTGNAVKFA 262
           +L ++ Y   +   ++GGLL+ +    F+   L   ++     ++++AG  TT   + + 
Sbjct: 137 KLRDIQYQMDRGRRVSGGLLTYL----FLSQALTLQEIYANVTEMLLAGVDTTSFTLSWT 192

Query: 263 LLSVLRNKNIQEKIFNEIENTIGDS-MPCWADSSKLVYTSAFLLEVMRIHTIAPLAGPRR 321
           +  + R+  +Q+ ++ EI   +G+  +P  AD  K+    A L E +R+  + P  G R 
Sbjct: 193 VYLLARHPEVQQTVYREIVKNLGERHVPTAADVPKVPLVRALLKETLRLFPVLPGNG-RV 251

Query: 322 VLQDTVIDGYVIPKETTV-LISLADIHLDPNLWPDPHEIKPERFIDEKGLSK-SNEHIYP 379
             +D VI GY+IPK T + L   A  + D N +P   E +PER++ +  L +  N    P
Sbjct: 252 TQEDLVIGGYLIPKGTQLALCHYATSYQDEN-FPRAKEFRPERWLRKGDLDRVDNFGSIP 310

Query: 380 FGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNGVLPSNEADIGLLAAPKPFVANFVS 439
           FG G R C G  +A   + ++ + +LQ + I   +     +    GLL    P    FV+
Sbjct: 311 FGHGVRSCIGRRIAELEIHLVVIQLLQHFEIKTSSQTNAVHAKTHGLLTPGGPIHVRFVN 370

Query: 440 RE 441
           R+
Sbjct: 371 RK 372


>AK127151-1|BAC86855.1|  146|Homo sapiens protein ( Homo sapiens
           cDNA FLJ45208 fis, clone BRCAN2015402, highly  similar
           to Cytochrome P450 2G1 (EC 1.14.14.1). ).
          Length = 146

 Score = 91.1 bits (216), Expect = 7e-18
 Identities = 41/112 (36%), Positives = 62/112 (55%)

Query: 299 YTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHE 358
           YT   + E+ R+  I P+  P  ++QDT   GY++PK T V   L  +  DP  +  P  
Sbjct: 3   YTDVVIHEIQRLVDIVPMGVPHNIIQDTQFRGYLLPKGTDVFPLLGSVLKDPKYFRYPDA 62

Query: 359 IKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRI 410
             P+ F+DE+G  K NE   PF SG+R C G+++AR  +F+ F   LQ + +
Sbjct: 63  FYPQHFLDEQGRFKKNEAFVPFSSGKRICLGEAMARMELFLYFTSTLQNFSL 114


>AF182273-1|AAF13598.1|  503|Homo sapiens cytochrome P450-3A4
           protein.
          Length = 503

 Score = 90.6 bits (215), Expect = 9e-18
 Identities = 59/197 (29%), Positives = 96/197 (48%), Gaps = 5/197 (2%)

Query: 248 IIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPCWADSS-KLVYTSAFLLE 306
           I AG +TT + + F +  +  + ++Q+K+  EI+  + +  P   D+  ++ Y    + E
Sbjct: 303 IFAGCETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNE 362

Query: 307 VMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERFID 366
            +R+  IA +   R   +D  I+G  IPK   V+I    +H DP  W +P +  PERF  
Sbjct: 363 TLRLFPIA-MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERF-S 420

Query: 367 EKGLSKSNEHIY-PFGSGRRRCPGDSLARSFVFIIFVGILQKYRI-DCVNGVLPSNEADI 424
           +K     + +IY PFGSG R C G   A   + +  + +LQ +    C    +P   +  
Sbjct: 421 KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG 480

Query: 425 GLLAAPKPFVANFVSRE 441
           GLL   KP V    SR+
Sbjct: 481 GLLQPEKPVVLKVESRD 497


>M18907-1|AAA35745.1|  503|Homo sapiens protein ( Human P450 mRNA
           encoding nifedipine oxidase, complete cds. ).
          Length = 503

 Score = 90.2 bits (214), Expect = 1e-17
 Identities = 59/197 (29%), Positives = 96/197 (48%), Gaps = 5/197 (2%)

Query: 248 IIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPCWADSS-KLVYTSAFLLE 306
           I AG +TT + + F +  +  + ++Q+K+  EI+  + +  P   D+  ++ Y    + E
Sbjct: 303 IFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNE 362

Query: 307 VMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERFID 366
            +R+  IA +   R   +D  I+G  IPK   V+I    +H DP  W +P +  PERF  
Sbjct: 363 TLRLFPIA-MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERF-S 420

Query: 367 EKGLSKSNEHIY-PFGSGRRRCPGDSLARSFVFIIFVGILQKYRI-DCVNGVLPSNEADI 424
           +K     + +IY PFGSG R C G   A   + +  + +LQ +    C    +P   +  
Sbjct: 421 KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG 480

Query: 425 GLLAAPKPFVANFVSRE 441
           GLL   KP V    SR+
Sbjct: 481 GLLQPEKPVVLKVESRD 497


>DQ924960-1|ABI96208.1|  503|Homo sapiens cytochrome P450 family 3
           subfamily A polypeptide 4 protein.
          Length = 503

 Score = 90.2 bits (214), Expect = 1e-17
 Identities = 59/197 (29%), Positives = 96/197 (48%), Gaps = 5/197 (2%)

Query: 248 IIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPCWADSS-KLVYTSAFLLE 306
           I AG +TT + + F +  +  + ++Q+K+  EI+  + +  P   D+  ++ Y    + E
Sbjct: 303 IFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNE 362

Query: 307 VMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERFID 366
            +R+  IA +   R   +D  I+G  IPK   V+I    +H DP  W +P +  PERF  
Sbjct: 363 TLRLFPIA-MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERF-S 420

Query: 367 EKGLSKSNEHIY-PFGSGRRRCPGDSLARSFVFIIFVGILQKYRI-DCVNGVLPSNEADI 424
           +K     + +IY PFGSG R C G   A   + +  + +LQ +    C    +P   +  
Sbjct: 421 KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG 480

Query: 425 GLLAAPKPFVANFVSRE 441
           GLL   KP V    SR+
Sbjct: 481 GLLQPEKPVVLKVESRD 497


>DQ005611-1|AAY16980.1|  503|Homo sapiens cytochrome P450, family 3,
           subfamily A, polypeptide 4 protein.
          Length = 503

 Score = 90.2 bits (214), Expect = 1e-17
 Identities = 59/197 (29%), Positives = 96/197 (48%), Gaps = 5/197 (2%)

Query: 248 IIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPCWADSS-KLVYTSAFLLE 306
           I AG +TT + + F +  +  + ++Q+K+  EI+  + +  P   D+  ++ Y    + E
Sbjct: 303 IFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNE 362

Query: 307 VMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERFID 366
            +R+  IA +   R   +D  I+G  IPK   V+I    +H DP  W +P +  PERF  
Sbjct: 363 TLRLFPIA-MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERF-S 420

Query: 367 EKGLSKSNEHIY-PFGSGRRRCPGDSLARSFVFIIFVGILQKYRI-DCVNGVLPSNEADI 424
           +K     + +IY PFGSG R C G   A   + +  + +LQ +    C    +P   +  
Sbjct: 421 KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG 480

Query: 425 GLLAAPKPFVANFVSRE 441
           GLL   KP V    SR+
Sbjct: 481 GLLQPEKPVVLKVESRD 497


>BC101631-1|AAI01632.1|  503|Homo sapiens cytochrome P450, subfamily
           IIIA, polypeptide 4 protein.
          Length = 503

 Score = 90.2 bits (214), Expect = 1e-17
 Identities = 59/197 (29%), Positives = 96/197 (48%), Gaps = 5/197 (2%)

Query: 248 IIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPCWADSS-KLVYTSAFLLE 306
           I AG +TT + + F +  +  + ++Q+K+  EI+  + +  P   D+  ++ Y    + E
Sbjct: 303 IFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNE 362

Query: 307 VMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERFID 366
            +R+  IA +   R   +D  I+G  IPK   V+I    +H DP  W +P +  PERF  
Sbjct: 363 TLRLFPIA-MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERF-S 420

Query: 367 EKGLSKSNEHIY-PFGSGRRRCPGDSLARSFVFIIFVGILQKYRI-DCVNGVLPSNEADI 424
           +K     + +IY PFGSG R C G   A   + +  + +LQ +    C    +P   +  
Sbjct: 421 KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG 480

Query: 425 GLLAAPKPFVANFVSRE 441
           GLL   KP V    SR+
Sbjct: 481 GLLQPEKPVVLKVESRD 497


>BC069418-1|AAH69418.1|  503|Homo sapiens cytochrome P450, family 3,
           subfamily A, polypeptide 4 protein.
          Length = 503

 Score = 90.2 bits (214), Expect = 1e-17
 Identities = 59/197 (29%), Positives = 96/197 (48%), Gaps = 5/197 (2%)

Query: 248 IIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPCWADSS-KLVYTSAFLLE 306
           I AG +TT + + F +  +  + ++Q+K+  EI+  + +  P   D+  ++ Y    + E
Sbjct: 303 IFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNE 362

Query: 307 VMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERFID 366
            +R+  IA +   R   +D  I+G  IPK   V+I    +H DP  W +P +  PERF  
Sbjct: 363 TLRLFPIA-MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERF-S 420

Query: 367 EKGLSKSNEHIY-PFGSGRRRCPGDSLARSFVFIIFVGILQKYRI-DCVNGVLPSNEADI 424
           +K     + +IY PFGSG R C G   A   + +  + +LQ +    C    +P   +  
Sbjct: 421 KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG 480

Query: 425 GLLAAPKPFVANFVSRE 441
           GLL   KP V    SR+
Sbjct: 481 GLLQPEKPVVLKVESRD 497


>AJ563377-1|CAD91345.1|  353|Homo sapiens cytochrome P450 protein.
          Length = 353

 Score = 90.2 bits (214), Expect = 1e-17
 Identities = 59/197 (29%), Positives = 96/197 (48%), Gaps = 5/197 (2%)

Query: 248 IIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPCWADSS-KLVYTSAFLLE 306
           I AG +TT + + F +  +  + ++Q+K+  EI+  + +  P   D+  ++ Y    + E
Sbjct: 153 IFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNE 212

Query: 307 VMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERFID 366
            +R+  IA +   R   +D  I+G  IPK   V+I    +H DP  W +P +  PERF  
Sbjct: 213 TLRLFPIA-MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERF-S 270

Query: 367 EKGLSKSNEHIY-PFGSGRRRCPGDSLARSFVFIIFVGILQKYRI-DCVNGVLPSNEADI 424
           +K     + +IY PFGSG R C G   A   + +  + +LQ +    C    +P   +  
Sbjct: 271 KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG 330

Query: 425 GLLAAPKPFVANFVSRE 441
           GLL   KP V    SR+
Sbjct: 331 GLLQPEKPVVLKVESRD 347


>AJ563376-2|CAD91645.1|  430|Homo sapiens cytochrome P450 protein.
          Length = 430

 Score = 90.2 bits (214), Expect = 1e-17
 Identities = 59/197 (29%), Positives = 96/197 (48%), Gaps = 5/197 (2%)

Query: 248 IIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPCWADSS-KLVYTSAFLLE 306
           I AG +TT + + F +  +  + ++Q+K+  EI+  + +  P   D+  ++ Y    + E
Sbjct: 230 IFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNE 289

Query: 307 VMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERFID 366
            +R+  IA +   R   +D  I+G  IPK   V+I    +H DP  W +P +  PERF  
Sbjct: 290 TLRLFPIA-MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERF-S 347

Query: 367 EKGLSKSNEHIY-PFGSGRRRCPGDSLARSFVFIIFVGILQKYRI-DCVNGVLPSNEADI 424
           +K     + +IY PFGSG R C G   A   + +  + +LQ +    C    +P   +  
Sbjct: 348 KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG 407

Query: 425 GLLAAPKPFVANFVSRE 441
           GLL   KP V    SR+
Sbjct: 408 GLLQPEKPVVLKVESRD 424


>AJ563375-1|CAD91343.1|  503|Homo sapiens cytochrome P450 protein.
          Length = 503

 Score = 90.2 bits (214), Expect = 1e-17
 Identities = 59/197 (29%), Positives = 96/197 (48%), Gaps = 5/197 (2%)

Query: 248 IIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPCWADSS-KLVYTSAFLLE 306
           I AG +TT + + F +  +  + ++Q+K+  EI+  + +  P   D+  ++ Y    + E
Sbjct: 303 IFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNE 362

Query: 307 VMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERFID 366
            +R+  IA +   R   +D  I+G  IPK   V+I    +H DP  W +P +  PERF  
Sbjct: 363 TLRLFPIA-MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERF-S 420

Query: 367 EKGLSKSNEHIY-PFGSGRRRCPGDSLARSFVFIIFVGILQKYRI-DCVNGVLPSNEADI 424
           +K     + +IY PFGSG R C G   A   + +  + +LQ +    C    +P   +  
Sbjct: 421 KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG 480

Query: 425 GLLAAPKPFVANFVSRE 441
           GLL   KP V    SR+
Sbjct: 481 GLLQPEKPVVLKVESRD 497


>AF280107-2|AAG32290.1|  503|Homo sapiens cytochrome P450
           polypeptide 4 protein.
          Length = 503

 Score = 90.2 bits (214), Expect = 1e-17
 Identities = 59/197 (29%), Positives = 96/197 (48%), Gaps = 5/197 (2%)

Query: 248 IIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPCWADSS-KLVYTSAFLLE 306
           I AG +TT + + F +  +  + ++Q+K+  EI+  + +  P   D+  ++ Y    + E
Sbjct: 303 IFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNE 362

Query: 307 VMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERFID 366
            +R+  IA +   R   +D  I+G  IPK   V+I    +H DP  W +P +  PERF  
Sbjct: 363 TLRLFPIA-MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERF-S 420

Query: 367 EKGLSKSNEHIY-PFGSGRRRCPGDSLARSFVFIIFVGILQKYRI-DCVNGVLPSNEADI 424
           +K     + +IY PFGSG R C G   A   + +  + +LQ +    C    +P   +  
Sbjct: 421 KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG 480

Query: 425 GLLAAPKPFVANFVSRE 441
           GLL   KP V    SR+
Sbjct: 481 GLLQPEKPVVLKVESRD 497


>AF209389-1|AAF21034.1|  503|Homo sapiens cytochrome P450 IIIA4
           protein.
          Length = 503

 Score = 90.2 bits (214), Expect = 1e-17
 Identities = 59/197 (29%), Positives = 96/197 (48%), Gaps = 5/197 (2%)

Query: 248 IIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPCWADSS-KLVYTSAFLLE 306
           I AG +TT + + F +  +  + ++Q+K+  EI+  + +  P   D+  ++ Y    + E
Sbjct: 303 IFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNE 362

Query: 307 VMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERFID 366
            +R+  IA +   R   +D  I+G  IPK   V+I    +H DP  W +P +  PERF  
Sbjct: 363 TLRLFPIA-MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERF-S 420

Query: 367 EKGLSKSNEHIY-PFGSGRRRCPGDSLARSFVFIIFVGILQKYRI-DCVNGVLPSNEADI 424
           +K     + +IY PFGSG R C G   A   + +  + +LQ +    C    +P   +  
Sbjct: 421 KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG 480

Query: 425 GLLAAPKPFVANFVSRE 441
           GLL   KP V    SR+
Sbjct: 481 GLLQPEKPVVLKVESRD 497


>BC035350-1|AAH35350.1|  524|Homo sapiens cytochrome P450, family 4,
           subfamily F, polypeptide 12 protein.
          Length = 524

 Score = 89.8 bits (213), Expect = 2e-17
 Identities = 51/166 (30%), Positives = 83/166 (50%), Gaps = 5/166 (3%)

Query: 248 IIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPC---WADSSKLVYTSAFL 304
           +  G  TT + + + L ++ R+   QE+   E++  + D  P    W D ++L + +  +
Sbjct: 326 MFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCV 385

Query: 305 LEVMRIHTIAPLAGPRRVLQDTVI-DGYVIPKETTVLISLADIHLDPNLWPDPHEIKPER 363
            E +R+H  AP    R   QD V+ DG VIPK  T LI +  +H +P +WPDP    P R
Sbjct: 386 KESLRLHPPAPFIS-RCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFR 444

Query: 364 FIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYR 409
           F  E    +S     PF +G R C G + A + + ++   +L  +R
Sbjct: 445 FDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFR 490


>AY358977-1|AAQ89336.1|  524|Homo sapiens CYP4F12 protein.
          Length = 524

 Score = 89.8 bits (213), Expect = 2e-17
 Identities = 51/166 (30%), Positives = 83/166 (50%), Gaps = 5/166 (3%)

Query: 248 IIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPC---WADSSKLVYTSAFL 304
           +  G  TT + + + L ++ R+   QE+   E++  + D  P    W D ++L + +  +
Sbjct: 326 MFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCV 385

Query: 305 LEVMRIHTIAPLAGPRRVLQDTVI-DGYVIPKETTVLISLADIHLDPNLWPDPHEIKPER 363
            E +R+H  AP    R   QD V+ DG VIPK  T LI +  +H +P +WPDP    P R
Sbjct: 386 KESLRLHPPAPFIS-RCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFR 444

Query: 364 FIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYR 409
           F  E    +S     PF +G R C G + A + + ++   +L  +R
Sbjct: 445 FDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFR 490


>AY008841-1|AAG33247.1|  524|Homo sapiens cytochrome P450 isoform
           4F12 protein.
          Length = 524

 Score = 89.8 bits (213), Expect = 2e-17
 Identities = 51/166 (30%), Positives = 83/166 (50%), Gaps = 5/166 (3%)

Query: 248 IIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPC---WADSSKLVYTSAFL 304
           +  G  TT + + + L ++ R+   QE+   E++  + D  P    W D ++L + +  +
Sbjct: 326 MFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCV 385

Query: 305 LEVMRIHTIAPLAGPRRVLQDTVI-DGYVIPKETTVLISLADIHLDPNLWPDPHEIKPER 363
            E +R+H  AP    R   QD V+ DG VIPK  T LI +  +H +P +WPDP    P R
Sbjct: 386 KESLRLHPPAPFIS-RCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFR 444

Query: 364 FIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYR 409
           F  E    +S     PF +G R C G + A + + ++   +L  +R
Sbjct: 445 FDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFR 490


>AC004523-1|AAC11543.1|  458|Homo sapiens F22329_1 protein.
          Length = 458

 Score = 89.8 bits (213), Expect = 2e-17
 Identities = 51/166 (30%), Positives = 83/166 (50%), Gaps = 5/166 (3%)

Query: 248 IIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPC---WADSSKLVYTSAFL 304
           +  G  TT + + + L ++ R+   QE+   E++  + D  P    W D ++L + +  +
Sbjct: 260 MFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCV 319

Query: 305 LEVMRIHTIAPLAGPRRVLQDTVI-DGYVIPKETTVLISLADIHLDPNLWPDPHEIKPER 363
            E +R+H  AP    R   QD V+ DG VIPK  T LI +  +H +P +WPDP    P R
Sbjct: 320 KESLRLHPPAPFIS-RCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFR 378

Query: 364 FIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYR 409
           F  E    +S     PF +G R C G + A + + ++   +L  +R
Sbjct: 379 FDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFR 424


>AB035131-1|BAB18270.1|  524|Homo sapiens cytochrome P450 protein.
          Length = 524

 Score = 89.8 bits (213), Expect = 2e-17
 Identities = 51/166 (30%), Positives = 83/166 (50%), Gaps = 5/166 (3%)

Query: 248 IIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPC---WADSSKLVYTSAFL 304
           +  G  TT + + + L ++ R+   QE+   E++  + D  P    W D ++L + +  +
Sbjct: 326 MFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCV 385

Query: 305 LEVMRIHTIAPLAGPRRVLQDTVI-DGYVIPKETTVLISLADIHLDPNLWPDPHEIKPER 363
            E +R+H  AP    R   QD V+ DG VIPK  T LI +  +H +P +WPDP    P R
Sbjct: 386 KESLRLHPPAPFIS-RCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFR 444

Query: 364 FIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYR 409
           F  E    +S     PF +G R C G + A + + ++   +L  +R
Sbjct: 445 FDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFR 490


>AB035130-1|BAB18269.1|  524|Homo sapiens cytochrome P450 protein.
          Length = 524

 Score = 89.8 bits (213), Expect = 2e-17
 Identities = 51/166 (30%), Positives = 83/166 (50%), Gaps = 5/166 (3%)

Query: 248 IIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPC---WADSSKLVYTSAFL 304
           +  G  TT + + + L ++ R+   QE+   E++  + D  P    W D ++L + +  +
Sbjct: 326 MFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCV 385

Query: 305 LEVMRIHTIAPLAGPRRVLQDTVI-DGYVIPKETTVLISLADIHLDPNLWPDPHEIKPER 363
            E +R+H  AP    R   QD V+ DG VIPK  T LI +  +H +P +WPDP    P R
Sbjct: 386 KESLRLHPPAPFIS-RCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFR 444

Query: 364 FIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYR 409
           F  E    +S     PF +G R C G + A + + ++   +L  +R
Sbjct: 445 FDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFR 490


>X12387-1|CAA30944.1|  503|Homo sapiens protein ( Human mRNA for
           cytochrome P-450 (cyp3 locus). ).
          Length = 503

 Score = 89.4 bits (212), Expect = 2e-17
 Identities = 59/197 (29%), Positives = 96/197 (48%), Gaps = 5/197 (2%)

Query: 248 IIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPCWADSS-KLVYTSAFLLE 306
           I AG +TT + + F +  +  + ++Q+K+  EI+  + +  P   D+  ++ Y    + E
Sbjct: 303 IFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNE 362

Query: 307 VMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERFID 366
            +R+  IA +   R   +D  I+G  IPK   V+I    +H DP  W +P +  PERF  
Sbjct: 363 TLRLFPIA-MRLERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERF-S 420

Query: 367 EKGLSKSNEHIY-PFGSGRRRCPGDSLARSFVFIIFVGILQKYRI-DCVNGVLPSNEADI 424
           +K     + +IY PFGSG R C G   A   + +  + +LQ +    C    +P   +  
Sbjct: 421 KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG 480

Query: 425 GLLAAPKPFVANFVSRE 441
           GLL   KP V    SR+
Sbjct: 481 GLLQPEKPVVLKVESRD 497


>M13785-1|AAA35742.1|  504|Homo sapiens protein ( Human liver
           glucocorticoid-inducible cytochrome P-450 (HLp) mRNA,
           complete cds. ).
          Length = 504

 Score = 89.4 bits (212), Expect = 2e-17
 Identities = 59/197 (29%), Positives = 96/197 (48%), Gaps = 5/197 (2%)

Query: 248 IIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPCWADSS-KLVYTSAFLLE 306
           I AG +TT + + F +  +  + ++Q+K+  EI+  + +  P   D+  ++ Y    + E
Sbjct: 304 IFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNE 363

Query: 307 VMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERFID 366
            +R+  IA +   R   +D  I+G  IPK   V+I    +H DP  W +P +  PERF  
Sbjct: 364 TLRLFPIA-MRLERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERF-S 421

Query: 367 EKGLSKSNEHIY-PFGSGRRRCPGDSLARSFVFIIFVGILQKYRI-DCVNGVLPSNEADI 424
           +K     + +IY PFGSG R C G   A   + +  + +LQ +    C    +P   +  
Sbjct: 422 KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG 481

Query: 425 GLLAAPKPFVANFVSRE 441
           GLL   KP V    SR+
Sbjct: 482 GLLQPEKPVVLKVESRD 498


>D00003-1|BAA00001.1|  504|Homo sapiens cytochrome P-450 protein.
          Length = 504

 Score = 89.4 bits (212), Expect = 2e-17
 Identities = 59/197 (29%), Positives = 96/197 (48%), Gaps = 5/197 (2%)

Query: 248 IIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPCWADSS-KLVYTSAFLLE 306
           I AG +TT + + F +  +  + ++Q+K+  EI+  + +  P   D+  ++ Y    + E
Sbjct: 304 IFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNE 363

Query: 307 VMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERFID 366
            +R+  IA +   R   +D  I+G  IPK   V+I    +H DP  W +P +  PERF  
Sbjct: 364 TLRLFPIA-MRLERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERF-S 421

Query: 367 EKGLSKSNEHIY-PFGSGRRRCPGDSLARSFVFIIFVGILQKYRI-DCVNGVLPSNEADI 424
           +K     + +IY PFGSG R C G   A   + +  + +LQ +    C    +P   +  
Sbjct: 422 KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG 481

Query: 425 GLLAAPKPFVANFVSRE 441
           GLL   KP V    SR+
Sbjct: 482 GLLQPEKPVVLKVESRD 498


>AK000366-1|BAA91114.1|  408|Homo sapiens protein ( Homo sapiens
           cDNA FLJ20359 fis, clone HEP16626. ).
          Length = 408

 Score = 88.6 bits (210), Expect = 4e-17
 Identities = 47/142 (33%), Positives = 76/142 (53%), Gaps = 2/142 (1%)

Query: 245 LDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSM-PCWADSSKLVYTSAF 303
           LD+++AG++TT   +++A L + R+ ++Q ++  E++  +G    P   D   L YTSA 
Sbjct: 235 LDMVMAGTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAV 294

Query: 304 LLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPER 363
           L EV R  T+ P   PR    DT + G+++PK T V+  L  + LD   W  P +  P  
Sbjct: 295 LHEVQRFITLLPHV-PRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGH 353

Query: 364 FIDEKGLSKSNEHIYPFGSGRR 385
           F+D  G     E   PF +G++
Sbjct: 354 FLDANGHFVKREAFLPFSAGQQ 375



 Score = 53.2 bits (122), Expect = 2e-06
 Identities = 39/135 (28%), Positives = 69/135 (51%), Gaps = 6/135 (4%)

Query: 64  LELSKQWSTQVLGLKLGRELVVVVYGEKNVRQVFSE--SEFDGRPNSFFYKLRCLGKRLG 121
           +ELS+++   V  + LGR+  VV+ G + V++  +    E   RP    ++L   G   G
Sbjct: 1   MELSERYGP-VFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGG--G 57

Query: 122 VTFVDGPLWREHRQFTVKHLKNVGFGKTSMELEIQNELKLLREYINDNKHKPIKVDSMFS 181
           + F  G  WR  RQFTV+ L ++G G+  +  +I  ELK L   ++  + +P  + ++  
Sbjct: 58  IFFSSGARWRAARQFTVRALHSLGVGREPVADKILQELKCLSGQLDGYRGRPFPL-ALLG 116

Query: 182 SAVMNVLWKYVAGER 196
            A  N+ +  + G R
Sbjct: 117 WAPSNITFALLFGRR 131


>M14096-1|AAA35744.1|  503|Homo sapiens protein ( Human cytochrome
           P-450 nifedipine oxidase mRNA, complet cds. ).
          Length = 503

 Score = 87.4 bits (207), Expect = 9e-17
 Identities = 58/197 (29%), Positives = 95/197 (48%), Gaps = 5/197 (2%)

Query: 248 IIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPCWADSS-KLVYTSAFLLE 306
           I AG +TT + + F +  +  + ++Q+K+  EI+  + +  P   D+  ++ Y    + E
Sbjct: 303 IFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNE 362

Query: 307 VMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERFID 366
            +R+  IA +   R   +D  I+G  IPK   V+I    +H DP  W +P +  PERF  
Sbjct: 363 TLRLFPIA-MRLERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERF-S 420

Query: 367 EKGLSKSNEHIY-PFGSGRRRCPGDSLARSFVFIIFVGILQKYRI-DCVNGVLPSNEADI 424
           +K     + + Y PFGSG R C G   A   + +  + +LQ +    C    +P   +  
Sbjct: 421 KKNKDNIDPYTYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG 480

Query: 425 GLLAAPKPFVANFVSRE 441
           GLL   KP V    SR+
Sbjct: 481 GLLQPEKPVVLKVESRD 497


>J04449-1|AAA35747.1|  502|Homo sapiens cytochrome P450 nifedipine
           oxidase protein.
          Length = 502

 Score = 87.4 bits (207), Expect = 9e-17
 Identities = 58/197 (29%), Positives = 95/197 (48%), Gaps = 5/197 (2%)

Query: 248 IIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPCWADSS-KLVYTSAFLLE 306
           I AG +TT + + F +  +  + ++Q+K+  EI+  + +  P   D+  ++ Y    + E
Sbjct: 302 IFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNE 361

Query: 307 VMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERFID 366
            +R+  IA +   R   +D  I+G  IPK   V+I    +H DP  W +P +  PERF  
Sbjct: 362 TLRLFPIA-MRLERVCKKDVEINGMFIPKGWVVMIPSYALHRDPKYWTEPEKFLPERF-S 419

Query: 367 EKGLSKSNEHIY-PFGSGRRRCPGDSLARSFVFIIFVGILQKYRI-DCVNGVLPSNEADI 424
           +K     + + Y PFGSG R C G   A   + +  + +LQ +    C    +P   +  
Sbjct: 420 KKNKDNIDPYTYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG 479

Query: 425 GLLAAPKPFVANFVSRE 441
           GLL   KP V    SR+
Sbjct: 480 GLLQPEKPVVLKVESRD 496


>AM233517-1|CAJ80720.1|  175|Homo sapiens cytochrome P450 1A1
           protein.
          Length = 175

 Score = 87.4 bits (207), Expect = 9e-17
 Identities = 45/130 (34%), Positives = 70/130 (53%), Gaps = 1/130 (0%)

Query: 237 NDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSM-PCWADSS 295
           ++++  + LDL  AG  T   A+ ++L+ ++ N  +Q KI  E++  IG S  P  +D S
Sbjct: 43  DEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRS 102

Query: 296 KLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPD 355
            L Y  AF+LE  R  +  P   P    +DT + G+ IPK   V ++   I+ D  LW +
Sbjct: 103 HLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVN 162

Query: 356 PHEIKPERFI 365
           P E  PERF+
Sbjct: 163 PSEFLPERFL 172


>BC016853-1|AAH16853.1|  524|Homo sapiens CYP4F11 protein protein.
          Length = 524

 Score = 86.2 bits (204), Expect = 2e-16
 Identities = 50/164 (30%), Positives = 81/164 (49%), Gaps = 5/164 (3%)

Query: 251 GSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPC---WADSSKLVYTSAFLLEV 307
           G  TT + + + L  + ++   QE+   E++  + D  P    W D ++L + +  + E 
Sbjct: 329 GHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIKES 388

Query: 308 MRIHTIAPLAGPRRVLQDTVI-DGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERFID 366
           +R+H   P+   R   QD V+ DG VIPK    LI++  IH +P +WPDP    P RF  
Sbjct: 389 LRLHPPVPVIS-RCCTQDFVLPDGRVIPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFNQ 447

Query: 367 EKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRI 410
           E    +S     PF +G R C G + A + + ++    L  +RI
Sbjct: 448 ENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRI 491


>AF236085-1|AAG15889.1|  524|Homo sapiens CYP4F11 protein.
          Length = 524

 Score = 86.2 bits (204), Expect = 2e-16
 Identities = 50/164 (30%), Positives = 81/164 (49%), Gaps = 5/164 (3%)

Query: 251 GSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPC---WADSSKLVYTSAFLLEV 307
           G  TT + + + L  + ++   QE+   E++  + D  P    W D ++L + +  + E 
Sbjct: 329 GHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIKES 388

Query: 308 MRIHTIAPLAGPRRVLQDTVI-DGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERFID 366
           +R+H   P+   R   QD V+ DG VIPK    LI++  IH +P +WPDP    P RF  
Sbjct: 389 LRLHPPVPVIS-RCCTQDFVLPDGRVIPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFNQ 447

Query: 367 EKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRI 410
           E    +S     PF +G R C G + A + + ++    L  +RI
Sbjct: 448 ENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRI 491


>U02388-1|AAC50052.2|  520|Homo sapiens cytochrome P450 4F2 protein.
          Length = 520

 Score = 85.8 bits (203), Expect = 3e-16
 Identities = 50/164 (30%), Positives = 81/164 (49%), Gaps = 5/164 (3%)

Query: 251 GSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPC---WADSSKLVYTSAFLLEV 307
           G  TT + + + L  + ++   QE+   E++  + D  P    W D + L + +  + E 
Sbjct: 329 GHDTTASVLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKES 388

Query: 308 MRIHTIAPLAGPRRVLQDTVI-DGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERFID 366
           +R+H   P+   R V QD V+ DG VIPK    LIS+   H +P +WPDP    P RF  
Sbjct: 389 LRVHPPVPVIS-RHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDP 447

Query: 367 EKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRI 410
           E    +S     PF +G R C G + A + + ++    L ++R+
Sbjct: 448 ENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRV 491


>BC067440-1|AAH67440.1|  520|Homo sapiens cytochrome P450, family 4,
           subfamily F, polypeptide 2 protein.
          Length = 520

 Score = 85.8 bits (203), Expect = 3e-16
 Identities = 50/164 (30%), Positives = 81/164 (49%), Gaps = 5/164 (3%)

Query: 251 GSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPC---WADSSKLVYTSAFLLEV 307
           G  TT + + + L  + ++   QE+   E++  + D  P    W D + L + +  + E 
Sbjct: 329 GHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKES 388

Query: 308 MRIHTIAPLAGPRRVLQDTVI-DGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERFID 366
           +R+H   P+   R V QD V+ DG VIPK    LIS+   H +P +WPDP    P RF  
Sbjct: 389 LRLHPPVPVIS-RHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAMWPDPEVYDPFRFDP 447

Query: 367 EKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRI 410
           E    +S     PF +G R C G + A + + ++    L ++R+
Sbjct: 448 ENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRV 491


>AB015306-1|BAA75823.1|  520|Homo sapiens Leukotriene B4
           omega-hydroxylase protein.
          Length = 520

 Score = 85.8 bits (203), Expect = 3e-16
 Identities = 50/164 (30%), Positives = 81/164 (49%), Gaps = 5/164 (3%)

Query: 251 GSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPC---WADSSKLVYTSAFLLEV 307
           G  TT + + + L  + ++   QE+   E++  + D  P    W D + L + +  + E 
Sbjct: 329 GHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKES 388

Query: 308 MRIHTIAPLAGPRRVLQDTVI-DGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERFID 366
           +R+H   P+   R V QD V+ DG VIPK    LIS+   H +P +WPDP    P RF  
Sbjct: 389 LRLHPPVPVIS-RHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAMWPDPEVYDPFRFDP 447

Query: 367 EKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRI 410
           E    +S     PF +G R C G + A + + ++    L ++R+
Sbjct: 448 ENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRV 491


>D26480-1|BAA05490.1|  520|Homo sapiens leukotriene B4
           omega-hydroxylase protein.
          Length = 520

 Score = 85.4 bits (202), Expect = 4e-16
 Identities = 50/164 (30%), Positives = 81/164 (49%), Gaps = 5/164 (3%)

Query: 251 GSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPC---WADSSKLVYTSAFLLEV 307
           G  TT + + + L  + ++   QE+   E++  + D  P    W D + L + +  + E 
Sbjct: 329 GHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKES 388

Query: 308 MRIHTIAPLAGPRRVLQDTVI-DGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERFID 366
           +R+H   P+   R V QD V+ DG VIPK    LIS+   H +P +WPDP    P RF  
Sbjct: 389 LRLHPPVPVIS-RHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDP 447

Query: 367 EKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRI 410
           E    +S     PF +G R C G + A + + ++    L ++R+
Sbjct: 448 ENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRV 491


>BC067439-1|AAH67439.1|  520|Homo sapiens cytochrome P450, family 4,
           subfamily F, polypeptide 2 protein.
          Length = 520

 Score = 85.4 bits (202), Expect = 4e-16
 Identities = 50/164 (30%), Positives = 81/164 (49%), Gaps = 5/164 (3%)

Query: 251 GSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPC---WADSSKLVYTSAFLLEV 307
           G  TT + + + L  + ++   QE+   E++  + D  P    W D + L + +  + E 
Sbjct: 329 GHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKES 388

Query: 308 MRIHTIAPLAGPRRVLQDTVI-DGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERFID 366
           +R+H   P+   R V QD V+ DG VIPK    LIS+   H +P +WPDP    P RF  
Sbjct: 389 LRLHPPVPVIS-RHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDP 447

Query: 367 EKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRI 410
           E    +S     PF +G R C G + A + + ++    L ++R+
Sbjct: 448 ENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRV 491


>BC067437-1|AAH67437.1|  520|Homo sapiens cytochrome P450, family 4,
           subfamily F, polypeptide 2 protein.
          Length = 520

 Score = 85.4 bits (202), Expect = 4e-16
 Identities = 50/164 (30%), Positives = 81/164 (49%), Gaps = 5/164 (3%)

Query: 251 GSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPC---WADSSKLVYTSAFLLEV 307
           G  TT + + + L  + ++   QE+   E++  + D  P    W D + L + +  + E 
Sbjct: 329 GHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKES 388

Query: 308 MRIHTIAPLAGPRRVLQDTVI-DGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERFID 366
           +R+H   P+   R V QD V+ DG VIPK    LIS+   H +P +WPDP    P RF  
Sbjct: 389 LRLHPPVPVIS-RHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDP 447

Query: 367 EKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRI 410
           E    +S     PF +G R C G + A + + ++    L ++R+
Sbjct: 448 ENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRV 491


>AF467894-1|AAL67578.1|  520|Homo sapiens cytochrome P450, subfamily
           IVF, polypeptide 2 protein.
          Length = 520

 Score = 85.4 bits (202), Expect = 4e-16
 Identities = 50/164 (30%), Positives = 81/164 (49%), Gaps = 5/164 (3%)

Query: 251 GSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPC---WADSSKLVYTSAFLLEV 307
           G  TT + + + L  + ++   QE+   E++  + D  P    W D + L + +  + E 
Sbjct: 329 GHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKES 388

Query: 308 MRIHTIAPLAGPRRVLQDTVI-DGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERFID 366
           +R+H   P+   R V QD V+ DG VIPK    LIS+   H +P +WPDP    P RF  
Sbjct: 389 LRLHPPVPVIS-RHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDP 447

Query: 367 EKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRI 410
           E    +S     PF +G R C G + A + + ++    L ++R+
Sbjct: 448 ENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRV 491


>AC005336-1|AAC27730.1|  520|Homo sapiens CYP4F2 protein.
          Length = 520

 Score = 85.4 bits (202), Expect = 4e-16
 Identities = 50/164 (30%), Positives = 81/164 (49%), Gaps = 5/164 (3%)

Query: 251 GSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPC---WADSSKLVYTSAFLLEV 307
           G  TT + + + L  + ++   QE+   E++  + D  P    W D + L + +  + E 
Sbjct: 329 GHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKES 388

Query: 308 MRIHTIAPLAGPRRVLQDTVI-DGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERFID 366
           +R+H   P+   R V QD V+ DG VIPK    LIS+   H +P +WPDP    P RF  
Sbjct: 389 LRLHPPVPVIS-RHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDP 447

Query: 367 EKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRI 410
           E    +S     PF +G R C G + A + + ++    L ++R+
Sbjct: 448 ENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRV 491


>AF133298-1|AAD49566.1|  520|Homo sapiens cytochrome P450 protein.
          Length = 520

 Score = 85.0 bits (201), Expect = 5e-16
 Identities = 50/167 (29%), Positives = 81/167 (48%), Gaps = 5/167 (2%)

Query: 248 IIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPC---WADSSKLVYTSAFL 304
           +  G  TT + + + L ++ R+   QE+   E++  + D  P    W D ++L + +  L
Sbjct: 326 MFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCL 385

Query: 305 LEVMRIHTIAPLAGPRRVLQDTVI-DGYVIPKETTVLISLADIHLDPNLWPDPHEIKPER 363
            E +R+H   P    R   QD V+ D  VIPK     I++  IH +P++WPDP    P R
Sbjct: 386 KESLRLHPPIPTFA-RGCTQDVVLPDSRVIPKGNVCNINIFAIHHNPSVWPDPEVYDPFR 444

Query: 364 FIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRI 410
           F  E    +S     PF +G R C G   A + + ++    L ++RI
Sbjct: 445 FDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTLLRFRI 491


>S67623-1|AAB29308.1|  257|Homo sapiens 25-hydroxyvitamin D
           24-hydroxylase cytochrome P450 subunit protein.
          Length = 257

 Score = 82.6 bits (195), Expect = 3e-15
 Identities = 49/177 (27%), Positives = 91/177 (51%), Gaps = 3/177 (1%)

Query: 239 QLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDS-MPCWADSSKL 297
           +L     +L +A  +TT N++ + L ++ RN  +Q+K+  EI++ + ++ +P   D   +
Sbjct: 58  ELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNM 117

Query: 298 VYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPH 357
            Y  A L E MR+    P    R + + TV+  Y +PK T ++++   +    + + D  
Sbjct: 118 PYLKACLKESMRLTPSVPFT-TRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSS 176

Query: 358 EIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVN 414
           + +PER++ EK       H+ PFG G+R C G  LA   + +    I++KY I   +
Sbjct: 177 QFRPERWLQEKEKINPFAHL-PFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATD 232


>AY858838-1|AAW50795.1|  372|Homo sapiens vitamin D 24-hydroxylase
           splice variant protein.
          Length = 372

 Score = 82.6 bits (195), Expect = 3e-15
 Identities = 49/177 (27%), Positives = 91/177 (51%), Gaps = 3/177 (1%)

Query: 239 QLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDS-MPCWADSSKL 297
           +L     +L +A  +TT N++ + L ++ RN  +Q+K+  EI++ + ++ +P   D   +
Sbjct: 173 ELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNM 232

Query: 298 VYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPH 357
            Y  A L E MR+    P    R + + TV+  Y +PK T ++++   +    + + D  
Sbjct: 233 PYLKACLKESMRLTPSVPFT-TRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSS 291

Query: 358 EIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVN 414
           + +PER++ EK       H+ PFG G+R C G  LA   + +    I++KY I   +
Sbjct: 292 QFRPERWLQEKEKINPFAHL-PFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATD 347


>AL138805-3|CAB91829.1|  514|Homo sapiens cytochrome P450, family
           24, subfamily A, polypeptide 1 protein.
          Length = 514

 Score = 82.6 bits (195), Expect = 3e-15
 Identities = 49/177 (27%), Positives = 91/177 (51%), Gaps = 3/177 (1%)

Query: 239 QLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDS-MPCWADSSKL 297
           +L     +L +A  +TT N++ + L ++ RN  +Q+K+  EI++ + ++ +P   D   +
Sbjct: 315 ELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNM 374

Query: 298 VYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPH 357
            Y  A L E MR+    P    R + + TV+  Y +PK T ++++   +    + + D  
Sbjct: 375 PYLKACLKESMRLTPSVPFT-TRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSS 433

Query: 358 EIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVN 414
           + +PER++ EK       H+ PFG G+R C G  LA   + +    I++KY I   +
Sbjct: 434 QFRPERWLQEKEKINPFAHL-PFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATD 489


>AL138805-1|CAM27342.1|  372|Homo sapiens cytochrome P450, family
           24, subfamily A, polypeptide 1 protein.
          Length = 372

 Score = 82.6 bits (195), Expect = 3e-15
 Identities = 49/177 (27%), Positives = 91/177 (51%), Gaps = 3/177 (1%)

Query: 239 QLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDS-MPCWADSSKL 297
           +L     +L +A  +TT N++ + L ++ RN  +Q+K+  EI++ + ++ +P   D   +
Sbjct: 173 ELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNM 232

Query: 298 VYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPH 357
            Y  A L E MR+    P    R + + TV+  Y +PK T ++++   +    + + D  
Sbjct: 233 PYLKACLKESMRLTPSVPFT-TRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSS 291

Query: 358 EIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVN 414
           + +PER++ EK       H+ PFG G+R C G  LA   + +    I++KY I   +
Sbjct: 292 QFRPERWLQEKEKINPFAHL-PFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATD 347


>Y07508-1|CAA68807.1|  503|Homo sapiens protein ( Human mRNA for
           aromatase P-450. ).
          Length = 503

 Score = 81.8 bits (193), Expect = 4e-15
 Identities = 49/171 (28%), Positives = 84/171 (49%), Gaps = 6/171 (3%)

Query: 245 LDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPCWADSSKLVYTSAFL 304
           L+++IA   T   ++ F L  + ++ N++E I  EI+  IG+      D  KL     F+
Sbjct: 301 LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI 360

Query: 305 LEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERF 364
            E MR   +  L   R+ L+D VIDGY + K T +++++  +H     +P P+E   E F
Sbjct: 361 YESMRYQPVVDLV-MRKALEDDVIDGYPVKKGTNIILNIGRMH-RLEFFPKPNEFTLENF 418

Query: 365 IDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNG 415
                 +    +  PFG G R C G  +A   +  I V +L+++ +  + G
Sbjct: 419 ----AKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQG 465


>X13589-1|CAA31929.1|  503|Homo sapiens protein ( Human mRNA for
           aromatase (estrogen synthetase). ).
          Length = 503

 Score = 81.8 bits (193), Expect = 4e-15
 Identities = 49/171 (28%), Positives = 84/171 (49%), Gaps = 6/171 (3%)

Query: 245 LDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPCWADSSKLVYTSAFL 304
           L+++IA   T   ++ F L  + ++ N++E I  EI+  IG+      D  KL     F+
Sbjct: 301 LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI 360

Query: 305 LEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERF 364
            E MR   +  L   R+ L+D VIDGY + K T +++++  +H     +P P+E   E F
Sbjct: 361 YESMRYQPVVDLV-MRKALEDDVIDGYPVKKGTNIILNIGRMH-RLEFFPKPNEFTLENF 418

Query: 365 IDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNG 415
                 +    +  PFG G R C G  +A   +  I V +L+++ +  + G
Sbjct: 419 ----AKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQG 465


>M30804-1|AAA35728.1|  503|Homo sapiens protein ( Human aromatase
           cytochrome P-450 gene, exon 10. ).
          Length = 503

 Score = 81.8 bits (193), Expect = 4e-15
 Identities = 49/171 (28%), Positives = 84/171 (49%), Gaps = 6/171 (3%)

Query: 245 LDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSMPCWADSSKLVYTSAFL 304
           L+++IA   T   ++ F L  + ++ N++E I  EI+  IG+      D  KL     F+
Sbjct: 301 LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI 360

Query: 305 LEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADIHLDPNLWPDPHEIKPERF 364
            E MR   +  L   R+ L+D VIDGY + K T +++++  +H     +P P+E   E F
Sbjct: 361 YESMRYQPVVDLV-MRKALEDDVIDGYPVKKGTNIILNIGRMH-RLEFFPKPNEFTLENF 418

Query: 365 IDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGILQKYRIDCVNG 415
                 +    +  PFG G R C G  +A   +  I V +L+++ +  + G
Sbjct: 419 ----AKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQG 465


  Database: human
    Posted date:  Oct 5, 2007 11:13 AM
  Number of letters in database: 73,234,838
  Number of sequences in database:  224,733
  
Lambda     K      H
   0.322    0.139    0.426 

Gapped
Lambda     K      H
   0.279   0.0580    0.190 


Matrix: BLOSUM62
Gap Penalties: Existence: 9, Extension: 2
Number of Hits to DB: 66,366,432
Number of Sequences: 224733
Number of extensions: 2763808
Number of successful extensions: 5676
Number of sequences better than 10.0: 468
Number of HSP's better than 10.0 without gapping: 424
Number of HSP's successfully gapped in prelim test: 44
Number of HSP's that attempted gapping in prelim test: 4591
Number of HSP's gapped (non-prelim): 667
length of query: 441
length of database: 73,234,838
effective HSP length: 92
effective length of query: 349
effective length of database: 52,559,402
effective search space: 18343231298
effective search space used: 18343231298
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 37 (14.9 bits)
X3: 62 (25.0 bits)
S1: 41 (21.9 bits)
S2: 67 (31.1 bits)